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Sample records for hydrochloride pcpa treatment

  1. Purification of a Flavobacterium pentachlorophenol-induced periplasmic protein (PcpA) and nucleotide sequence of the corresponding gene (pcpA).

    OpenAIRE

    Xun, L Y; Orser, C S

    1991-01-01

    A pentachlorophenol (PCP)-induced periplasmic protein (PcpA) with a molecular weight of 30,000 has been identified and purified from Flavobacterium sp. strain ATCC 39723. Results suggest that PcpA may be involved in PCP mineralization. The induction of PcpA correlated with the induction of PCP-degrading activity. When PcpA was released from the periplasmic space by EDTA or osmotic shock treatment, PCP-degrading activity was arrested. Two PCP- mutants of ATCC 39723, which do not degrade PCP, d...

  2. Mutational analysis of pcpA and its role in pentachlorophenol degradation by Sphingomonas (Flavobacterium) chlorophenolica ATCC 39723.

    OpenAIRE

    Chanama, S; Crawford, R L

    1997-01-01

    Sphingomonas (Flavobacterium) chlorophenolica ATCC 39723 degrades pentachlorophenol (PCP) through a catabolic pathway encoded by multiple genes. One gene required for PCP degradation is pcpA, which encodes information for a 30-kDa polypeptide, PcpA, found in the periplasm of the bacterium. The biological role of PcpA has remained unknown. We disrupted pcpA by replacing it with a defective copy through homologous recombination. The pcpA recombinant, mutant strains accumulated 2,6-dichlorohydro...

  3. Inhibition not facilitation of sexual behavior by PCPA.

    Science.gov (United States)

    Gorzalka, B B; Whalen, R E

    1975-01-01

    It has been proposed that estrous behavior in the female rat may be under tonic inhibition by a central serotonergi system. Studies conbining estrogen priming and the pharmacological depletion of serotonin have provided some support for this hypothesis. Some evidence, however, is not consistent with this hypothesis. In the present study estrogen primed ovariectomized-adrenalectomized rats were administered p-chlorophenylalanine and were tested for lordosis behavior 66 and 70 hr later. Lordosis was not facilitated. The animals were then administered progesterone and retested at hour 74. PCPA inhibited progesterone-induced lordosis behavior in a dose dependent manner.

  4. The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study.

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    Touret, M; Sarda, N; Gharib, A; Geffard, M; Jouvet, M

    1991-01-01

    In the rat, the insomnia which follows the administration of parachlorophenylalanine (p-CPA), a serotonin synthesis inhibitor, is transiently reversed either by intra-cisternal injection of L-5-HTP or by an associated injection of 5-HTP and an L-aromatic-acid-decarboxylase inhibitor (benserazide). Histochemical, immunohistochemical and chemical investigations showed that 5-HTP administration does not lead to a detectable increase in cerebral 5-HT. These findings suggest that the restoration of sleep after p-CPA treatment could be mediated by the central action of 5-HTP.

  5. Treatment of allergic conjunctivitis with olopatadine hydrochloride eye drops

    OpenAIRE

    Eiichi Uchio

    2008-01-01

    Eiichi UchioDepartment of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, JapanAbstract: Olopatadine hydrochloride exerts a wide range of pharmacological actions such as histamine H1 receptor antagonist action, chemical mediator suppressive action, and eosinophil infiltration suppressive action. Olopatadine hydrochloride 0.1% ophthalmic solution (Patanol®) was introduced to the market in Japan in October 2006. In a conjunctival allergen challenge (CAC) test, olopatadine...

  6. Spotlight on anagrelide hydrochloride for the treatment of essential thrombocythemia

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    Sarma A

    2017-01-01

    Full Text Available Anita Sarma,1 Donal P Mclornan,1,2 Claire N Harrison2 1Department of Haematology, King’s College Hospital NHS Foundation Trust, 2Department of Haematology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK Abstract: Anagrelide (ANA hydrochloride is an oral imidazoquinazoline registered as an orphan drug in Europe. It is indicated as a second-line agent for the reduction of thrombocytosis in high-risk essential thrombocythemia (ET in Europe and in any myeloproliferative neoplasm-associated thrombocytosis and for the amelioration of thrombo-hemorrhagic events in the context of myeloproliferative neoplasm in the USA and Japan. The compound has been in clinical use for almost two decades with approval in the European Union (EU for over a decade. The licensed indication encompasses the apparently specific action of the drug to reduce the platelet count; however, the precise mode of action of ANA remains unclear. Here, we review the current data from two large phase 3 studies, PT-1 and ANAHDRET, and a phase 4 post-approval observational study EXELS. All of these studies were conducted in the EU and therefore pertain to ET as the only licensed indication. Data from these studies suggest that ANA is on the whole as effective as the most commonly used agent hydroxycarbamide (HC. Although ANA, when compared to HC, appears to be slightly less effective in preventing arterial thrombosis and myelofibrotic transformation, it is associated with lower risk of venous thrombosis. Since the initial data from the PT-1 study, a caution has been recommended for the combined use of ANA and aspirin as this may provoke excess hemorrhage. ET is a clinically and biologically heterogeneous condition, and these biological variations may in part explain some of the clinical differences observed in various studies in response to specific treatments. No new toxicities of ANA have emerged in the past decade, which means that clinicians and patients can be reassured

  7. Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation

    Institute of Scientific and Technical Information of China (English)

    Bayoumy I Eassa; Mohamed A El-Shazly

    2013-01-01

    Premature ejaculation (PE) is the most common sexual disorder.It affects 20%-30% of adult men; the aetiology of this condition has not yet been elucidated.The aim of this study is to evaluate the efficacy,safety,tolerability,undesirable effects and improved satisfaction with sexual intercourse with tramadol hydrochloride at different dosages for the treatment of PE.A total of 300 patients who presented with lifelong (primary) PE were included in this study.The study was performed for 28 weeks,in which placebo (starch tablet) was given for 4 weeks,and active ingredient (tramadol hydrochloride) was administered at different therapeutic dosages for 24 weeks.Patients were divided into three equal groups,each consisting of 100 patients.The first group (A) was given tramadol hydrochloride capsule 25 mg.The second group (B) was given tramadol hydrochloride capsule 50 mg.The third group (C) was given tramadol hydrochloride capsule 100 mg.All of the 300 participants included completed the study voluntarily.The age of the patients varied from 25 to 50 years.After the treatment period,the recorded data were collected for each group and analysed.The results showed a highly significant increase in the mean intravaginal ejaculatory latency time (IELT) in all groups compared to baseline data (P<0.0001).We concluded that using tramadol hydrochloride at different doses on demand for the treatment of PE is effective,safe and tolerable,with minimal undesirable effects,and approval for this indication should be sought.

  8. Clinical trials of betahistine hydrochloride in the treatment of Ménière's disease.

    Science.gov (United States)

    Segers, J M; Boedts, D

    1975-01-01

    Thirty Ménière patients were treated with betahistine hydrochlorid for an average period of 17 months. The majority of them had been resistent to every previous treatment. The results of this new treatment were very gratifying with respect to the attacks of vertigo and the accompanying neuro-vegetative symptoms. The tinnitus aurium proved to be resistent, whereas the auditory acuity was significantly improved in 7 patients. Early treatment with this product at the first signs of Ménière's disease is very likely to hold up the progressive degradation of auditory acuity, during the further spontaneous evolution of the disease.

  9. Erlotinib hydrochloride.

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    Minna, John D; Dowell, Jonathan

    2005-05-01

    Erlotinib hydrochloride (Tarceva; OSI Pharmaceuticals/Genentech/Roche), a member of a class of targeted anticancer drugs that inhibit the activity of the epidermal growth factor receptor, was approved by the US FDA in November 2004 for the treatment of advanced non-small-cell lung cancer after failure of at least one prior chemotherapy regimen. It is the first such drug to demonstrate an increase in survival in Phase III trials in patients with advanced non-small-cell lung cancer.

  10. Recovery of cognitive dysfunction in a case of delayed encephalopathy of carbon monoxide poisoning after treatment with donepezil hydrochloride

    OpenAIRE

    Wang Pin; Zeng Tao; Chi Zhao-fu

    2009-01-01

    Delayed encephalopathy following carbon monoxide poisoning is a serious complication. Here, we report a patient with delayed encephalopathy who suffered from cognitive disorders and urinary incontinence after a temporal normal period of 15 days after acute intoxication, and his cognitive function recovered gradually following donepezil hydrochloride treatment. Now, he can undertake slight farming work.

  11. Recovery of cognitive dysfunction in a case of delayed encephalopathy of carbon monoxide poisoning after treatment with donepezil hydrochloride

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    Wang Pin

    2009-01-01

    Full Text Available Delayed encephalopathy following carbon monoxide poisoning is a serious complication. Here, we report a patient with delayed encephalopathy who suffered from cognitive disorders and urinary incontinence after a temporal normal period of 15 days after acute intoxication, and his cognitive function recovered gradually following donepezil hydrochloride treatment. Now, he can undertake slight farming work.

  12. TO EVALUATE THE PHARMACOTHERAPEUTIC EFFICACY OF TIZANIDINE HYDROCHLORIDE AND GABAPENTIN IN TREATING MYOFASCIAL PAIN-IN A STEPWISE TREATMENT APPROACH

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    Mohsin Muzaffar

    2015-11-01

    Full Text Available : AIMS: To evaluate, the pharmacotherapeutic efficacy of Tizanidine hydrochloride and Gabapentin in patients with persistent myofascial pain and to identify patient and pain characteristics that may predict treatment outcome. METHODS: A stepped Pharmacotherapeutic protocol was employed. All 40 patients having persistent facial pain with tenderness of regional muscles were first prescribed Tizanidine hydrochloride. In patients where no response to Tizanidine hydrochloride was observed, Gabapentin was initiated. Outcome was assessed by employing prospective diaries recording pain intensity measured with an 11-point (0–10 Visual Analog scale (VAS. Individual characteristics in these patients and their influence on drug response and outcome were analyzed; specifically, patients treated with Tizanidine hydrochloride were compared with those subsequently treated with Gabapentin. Chisquare and t tests were used to analyze the data. RESULTS: A total of 22 patients responded to Tizanidine hydrochloride and continued on this regimen, while 18 were resistant to Tizanidine hydrochloride and were subsequently treated with Gabapentin. However when the comparison was done in the intra group pain intensity at the base line and at the end of 6 weeks it was seen that in the group 1 the mean value at the baseline was 6.3 and for group 2 the mean value at the baseline was 5.9 and at the mean value at the end of 6 weeks was 2.11 in group1 and 2.06 In group 2 which showed a significant improvement in the pain intensity in both the groups, significant statistical difference was noted with the, (P-value<0.05. Patients who did not respond to Tizanidine hydrochloride were characterized by a significantly higher age, more comorbid medical illness, and evidence of more regional pain spread. Overall, a stepped approach employing Tizanidine and gabapentin resulted in overall improvement in the treatment outcome. CONCLUSION: This study has demonstrated the good

  13. Anamorelin hydrochloride in the treatment of cancer anorexia-cachexia syndrome.

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    Currow, David C; Abernethy, Amy P

    2014-04-01

    Anamorelin hydrochloride is an orally active ghrelin receptor agonist in development by Helsinn, for the treatment of non-small-cell lung cancer (NSCLC) cachexia. In preclinical and clinical studies, the potent affinity of anamorelin for the ghrelin receptor is associated with significant appetite-enhancing activity and resultant improvements in body weight, lean body mass, and handgrip strength compared with placebo. The accompanying stimulatory effects on growth hormone and IGF-1 are not associated with tumor growth, and overall survival in patients with cancer is not compromised. Anamorelin is well tolerated with no dose-limiting toxicities identified to date. The findings of ongoing Phase III studies are needed to confirm the significant potential of anamorelin to treat NSCLC cachexia.

  14. Symptomatic hepatic cyst in a child: treatment with single-shot injection of tetracycline hydrochloride

    Energy Technology Data Exchange (ETDEWEB)

    Fabrizzi, Giancarlo; Lanza, Cecilia; Bolli, Valeria; Pieroni, Giovanni [Azienda Ospedaliero-Universitaria Ospedali Riuniti, Servizio di Radiologia Generale e Pediatrica, Ancona (Italy)

    2009-10-15

    The prevalence of hepatic cysts is 0.1% to 0.5% based on autopsy studies, and 2.5% based on US examinations. Percutaneous therapies are a new alternative to surgery. They include simple percutaneous aspiration, catheter drainage alone, and catheter drainage with sclerotherapy. We present an 11-year-old boy admitted to hospital because of abdominal pain. A diagnosis of simple hepatic cyst was made, which was treated with aspiration and tetracycline hydrochloride solution (5%) injection into the cystic cavity. Complete regression was seen on US and MRI examination at 3 months, with total collapse and deflation of the cyst. The cyst regressed totally, leaving a hyperechoic linear scar on US examination at 1 year. On the basis of the clinical and imaging results obtained, percutaneous sclerotherapy of hepatic cysts can be recommended as the treatment of choice and as a valid alternative to laparoscopy in children. (orig.)

  15. Glucosamine hydrochloride

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    ... combination of glucosamine hydrochloride, chondroitin sulfate, and manganese ascorbate. Some evidence suggests that this combination can improve ... combination of glucosamine hydrochloride, chondroitin sulfate, and calcium ascorbate twice daily reduces joint swelling and pain, as ...

  16. Use of vancomycin hydrochloride for treatment of Clostridium difficile enteritis in Syrian hamsters.

    Science.gov (United States)

    Boss, S M; Gries, C L; Kirchner, B K; Smith, G D; Francis, P C

    1994-02-01

    As part of an 18-month carcinogenicity study, 680 Syrian hamsters (Mesocricetus auratus) received daily gavage doses of fenazaquin, an experimental miticide. Mortality associated with severe enteritis was noticed beginning when the hamsters were 4 months old and ranged from one to five deaths per month until the hamsters were about 10 months old, when 41 deaths occurred in a 1-month period. Ante- and postmortem findings were consistent with those reported for antibiotic-induced enteritis in hamsters. Clostridium difficile was isolated from 12 of the 13 samples of cecal contents analyzed. Toxin assays of C. difficile isolates collected from 11 affected animals were positive for both cyto- and enterotoxins. Daily oral administration of vancomycin hydrochloride at a dose of 20 mg/kg was initiated when the hamsters were about 10 months old. Deaths due to C. difficile enteritis were significantly decreased within 2 weeks, and treatment was continued for 3 months. A trial withdrawal period for a subset of 64 hamsters (approximately 16% of the total population) was initiated to evaluate survival after discontinuation of the antibiotic treatment. Clostridium difficile enteritis recurred within 2 weeks and caused 19 deaths during the next month; therefore, these hamsters were returned to daily vancomycin treatment for the remainder of the study. With the exception of severe gaseous distention of the ceca, which caused death in 17 (< 4% of the total population) of the affected hamsters, vancomycin treatment did not cause any major adverse effects.(ABSTRACT TRUNCATED AT 250 WORDS)

  17. Terbinafine hydrochloride loaded liposome film formulation for treatment of onychomycosis: in vitro and in vivo evaluation.

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    Tanrıverdi, Sakine Tuncay; Hilmioğlu Polat, Süleyha; Yeşim Metin, Dilek; Kandiloğlu, Gülşen; Özer, Özgen

    2016-01-01

    Onychomycosis is a fungal infection of nail unit that is caused by dermatophytes. Oral Terbinafine hydrochloride (TBF-HCl) is being used for the treatment of onychomycosis since 24 years. The side effects caused by the systemic application and limitations of topical administration of this drug regarding the diffusion through nail lead to the development of a new formulation based on, TBF-HCl-loaded liposome. The newly obtained film formulations were prepared and characterized via several parameters, such as physical appearance, drug content, thickness, bioadhesive properties and tensile strength. In vitro and ex vivo permeation studies were performed to select an optimum film formulation for antifungal activity to show the efficiency of formulations regarding the treatment of onychomycosis. The in vitro release percentages of drug were found 71.6 ± 3.28, 54.4 ± 4.26, 56.1 ± 7.48 and 46.0 ± 2.43 for liposome loaded pullulan films (LI-P, LII-P) and liposome loaded Eudragit films (LI-E, LII-E), respectively. The accumulated drug in the nail plates were found 31.16 ± 4.22, 24.81 ± 5.35, 8.17 ± 1.81 and 8.92 ± 3.37 for LI-P, LII-P, LI-E and LII-E, respectively, which within therapeutic range for all film formulations. The accumulated drug in the nail plate was found within therapeutic range for all film formulations. The efficacy of the selected TBF-HCl-loaded liposome film formulation was compared with TBF-HCl-loaded liposome, ethosome, liposome poloxamer gel and ethosome chitosan gel formulations. It was found that TBF-HCl-loaded liposome film formulation had better antifungal activity on fungal nails which make this liposome film formulation promising for ungual therapy of fungal nail infection.

  18. Development of cost effective biodegradable implants of ciprofloxacin hydrochloride in treatment of osteomyelitis

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    Ashish Y Pawar

    2013-01-01

    Full Text Available In the present study, an attempt has been made to formulate and evaluate a sustained release implant of ciprofloxacin HCl with biodegradable, cost-effective polymer chitosan. osteomyelitis is one of the oldest disease, which is still in existence and difficult to treat, the prevalence of which is increasing day-by-day. The treatment of osteomyelitis requires large doses of antibiotics administered by systemic routes for a period of 4-5 weeks, however, the parenteral route suffered from many disadvantages and also some limitations. Ciprofloxacin hydrochloride has been the most widely used fluoroquinolone for multi-bacterial bone infection because the minimal inhibitory concentration of ciprofloxacin HCl is low, and it has good penetration properties in most of the tissues and bone. Biodegradable polymers like poly (lactic-co-glycolic acid (PLGA and Polycaprolactone (PCL were widely studied as a carrier for implant but their use is limited because of high-cost and are not easily available. The cross-linking of chitosan was carried out with sodium citrate and cross-linked chitosan (CC was used as a carrier. The effect of different proportion of chitosan and effect of drug loading on the drug release kinetics has been studied. An in vitro result shows that prolonged release was observed with higher drug loading. The CC5 implant containing 50% w/w polymer retards the drug release for more than 5 weeks. Furthermore, from in vivo study it is found that the optimized formulation CC5 is biocompatible and implant is not causing any foreign body reaction or hypersensitivity in the body of animal. The CC was found to have excellent release retarding properties and can be used as cost-effective, biodegradable sustained release matrices for designing of implant.

  19. Crystal Structure and Fluorescent Property of a 2D Coordination Polymer: [Eu(PCPA)3(H2O)]n

    Institute of Scientific and Technical Information of China (English)

    SUN Rui-Qing; ZHANG Han-Hui; CAO Yan-Ning; CHEN Yi-Ping; WANG Zhen; YANG Qi-Yu

    2006-01-01

    The title coordination polymer [Eu(PCPA)3(H2O)]n (PCPA = p-chlorophenoxyacetate) has been synthesized under hydrothermal condition, determined by single-crystal X-ray diffraction and characterized by FT-IR, UV-VIS and fluorescent spectra. The crystal belongs to triclinic system, space group P1 with a = 7.8036(1), b = 12.7458(4), c = 14.0208(3) (A), α =81.610(8), β = 79.406(8), γ = 77.567(7)°, V = 1330.40(5) (A)3, C24H20Cl3EuO10, Mr = 726.71, Z = 2,F(000) = 716, Dc= 1.814 g/cm3, λ(MoKα) = 0.71073 (A), μ(MoKα) = 2.713 mm-1, the final R =0.0284 and wR = 0.0678 for 5529 observed reflections with 1 > 2σ(Ⅰ). The europium ions are located in a nine-coordinate environment. PCPA ions with two different coordination modes connect the metal ions to form 1D zigzag chains which are arranged to generate 2D supramolecular layers by intermolecular hydrogen bonds. The luminescence properties of the rare-earth ions are studied in this paper.

  20. Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases

    Institute of Scientific and Technical Information of China (English)

    Giuseppe Merra; Giovanni Gasbarrini; Lucrezia Laterza; Marco Pizzoferrato; Andrea Poscia; Franco Scaldaferri; Vincenzo Arena

    2012-01-01

    AIM:To assess clinical and endoscopic response to propionyl-L-carnitine hydrochloride (PLC) in colonic inflammatory bowel disease.METHODS:Patients suffering from mild to moderate ulcerative colitis (UC) or Crohn's disease (CD) colitis,with disease activity index (DAI) between 3 and 10 and under stable therapy with oral aminosalicylates,mercaptopurine or azathioprine,for at least 8 wk prior to baseline assessments,were considered suitable for enrollment.Fourteen patients were enrolled to assume PLC 2 g/d (two active tablets twice daily) orally.Clinical-endoscopic and histological activity were assessed by DAI and histological index (HI),respectively,following a colonoscopy performed immediately before and after 4 wk treatment.Clinical response was defined as a lowering of at least 3 points in DAI and clinical remission as a DAI score ≤ 2.Histological response was defined as an improvement of HI of at least 1 point.We used median values for the analysis.Differences pre-and post-treatment were analyzed by Wilcoxon signed rank test.RESULTS:All patients enrolled completed the study.One patient,despite medical advice,took deflazacort 5 d before follow-up colonoscopy examination.No side effects were reported by patients during the trial.After treatment,71% (SE 12%) of patients achieved clinical response,while 64% (SE 13%) obtained remission.Separating UC from CD patients,we observed a clinical response in 60% (SE 16%) and 100%,respectively.Furthermore 60% (SE 16%) of UC patients and 75% (SE 25%) of CD patients were in clinical remission after therapy.The median DAI was 7 [interquartile range (IQR):4-8] before treatment and decreased to 2 (IQR:1-3) (P < 0.01) after treatment.Only patients with UC showed a significant reduction of DAI,from a median 6.5 (IQR:4-9) before treatment to 2(IQR:1-3) after treatment (P < 0.01).Conversely,in CD patients,although displaying a clear reduction of DAI from 7 (IQR:5.5-7.5) before therapy to 1.5 (IQR:0

  1. Supplementary guanfacine hydrochloride as a treatment of attention deficit hyperactivity disorder in adults: A double blind, placebo-controlled study.

    Science.gov (United States)

    Butterfield, Max E; Saal, Jaime; Young, Benjamin; Young, Joel L

    2016-02-28

    The purpose of this study was to examine the efficacy of an extended release guanfacine hydrochloride supplement relative to a placebo supplement in adults (19-62) with ADHD and a sub-optimal response to a stimulant-only treatment program. The study's primary outcome measures were the Attention Deficit Hyperactivity Disorder Rating Scale and the Clinical Global Impression - Severity. Twenty-six adults who met criteria for attention deficit hyperactivity disorder and sub-optimal functioning were randomly assigned to supplement their existing psychostimulant treatment regimen with either a titrated dose (1-6mg) of extended release guanfacine hydrochloride or a matching placebo for a 10-week trial. The data were analyzed with standard mixed model analysis of variance procedures, and participants in both the investigational agent group and the placebo group showed statistically significant improvement in their symptoms and functioning over the course of the trial. The treatments did not differ in terms of their efficacy, safety, or tolerability. Although these results do suggest that both treatments were associated with clinical improvement, the possible impacts of socially desirable responding and regression to the mean on these results are discussed.

  2. Research on Treatment of Phenylhydrazine Hydrochloride Wastewater%盐酸苯肼废水的治理研究

    Institute of Scientific and Technical Information of China (English)

    陶秀成; 魏冬; 鲍习芝

    2013-01-01

    Phenylhydrazine hydrochloride was the intermediates in the process of producing pesticide and medicine, and it would bring toxic wastewater with composition complex in production process. The wastewater comprehensive treatment by resin adsorp-tion and Fenton oxidation could greatly improve the biodegradability.%  盐酸苯肼是生产农药、医药等的中间体,在其生产过程中产生的废水成分复杂,毒性大,采用树脂吸附和Fenton氧化法综合处理后其可生化性大大提高。

  3. Preparation and characterisation of mucoadhesive nasal gel of venlafaxine hydrochloride for treatment of anxiety disorders

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    Shyamoshree Basu

    2012-01-01

    Full Text Available The aim of the present study is to prepare and evaluate mucoadhesive nasal gels of venlafaxine hydrochloride. Mucoadhesive nasal gels were prepared using polymers like carbopol 934 and sodium alginate and characterized in terms of viscosity, texture profile analysis, ex vivo drug permeation profiles and histopathological studies. The results show that values of viscosity, hardness and adhesiveness increase while those of cohesiveness decrease with corresponding increase in concentration of the polymers. Ex vivo drug permeation profiles showed that formulation containing 5% sodium alginate provided a better controlled release of the drug than the other formulations over a period of 12 h. Histopathological studies assured that gels containing different polymers did not produce any significant change in the nasal mucosae of goat even after 12 h permeation study. Mucoadhesive nasal gel of venlafaxine hydrochloride is a novel dosage form which delivers the drug directly into systemic circulation and provides controlled release of the drug.

  4. Double-blind study of benzydamine hydrochloride, a new treatment for sore throat.

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    Wethington, J F

    1985-01-01

    Forty-four patients with sore throat participated in a placebo-controlled, double-blind clinical trial of benzydamine hydrochloride administered as a gargle. After medical evaluation and throat culture, 21 patients were treated with a solution containing benzydamine and 23 patients with a placebo solution. Statistical analysis of scores from patients' diaries showed that benzydamine solution afforded significantly greater (P less than 0.001) relief of pain and dysphagia at 24 hours than did the placebo solution. Physician evaluations at 24 hours showed that the benzydamine solution had significantly greater effect than did placebo on hyperemia (P less than 0.004) and edema (P less than 0.005). Side effects were minimal and of no clinical significance. The findings indicate that benzydamine hydrochloride is safe and effective therapy for the signs and symptoms of sore throat.

  5. Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru

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    Llanos-Cuentas A.

    2001-01-01

    Full Text Available The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru. Patients were initially randomized to receive 1,000 mg atovaquone and 400 mg proguanil hydrochloride daily for 3 days (n=15 or 1,500 mg chloroquine (base over a 3 day period (n=14 (phase 1. The cure rate with chloroquine was lower than expected and patients were subsequently randomized to receive a single dose of 75 mg pyrimethamine and 1,500 mg sulfadoxine (n=9 or atovaquone/proguanil as before (n=5 (phase 2. In phase 1, atovaquone/proguanil was significantly more effective than chloroquine (cure rate 100% [14/14] versus 8% [1/13], P<0.0001. In phase 2, atovaquone/proguanil and pyrimethamine/sulfadoxine were both highly effective (cure rates 100% [5/5] and 100% [7/7]. There were no significant differences between treatment groups in parasite or fever clearance times. Adverse events were typical of malarial symptoms and did not differ significantly between groups. Overall efficacy of atovaquone/proguanil was 100% for treatment of acute falciparum malaria in a region with a high prevalence of chloroquine resistance.

  6. DESIGN AND OPTIMIZATION OF CONTROLLED RELEASE OCULAR INSERTS OF DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE FOR TREATMENT OF GLAUCOMA

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    K.M. Manjunatha et al

    2012-10-01

    Full Text Available Goal of the present investigation was to formulate ocular inserts of dorzolamide hydrochloride and timolol maleate for the treatment of glaucoma. Ocular inserts of dorzolamide hydrochloride and timolol maleate were prepared using different polymers ethylcellulose, Eudragit RL 100, and Eudragit RS100 by solvent casting method with an objective to increasing the contact time, achieving controlled release, reducing in frequency of administration, and improving therapeutic efficacy. The drug-excipients interaction was studied by Fourier transform infrared spectroscopy (FTIR studies. Prepared ocular inserts were evaluated for their physicochemical properties such as uniformity of thickness, weight uniformity, tensile strength, percentage elongation, drug content, moisture loss, moisture absorption. The in vitro diffusion of drug from the inserts was studied using the classical biochemical donor - receptor compartment model fabricated in the laboratory and the formulation that showed better release profile was subjected to in vivo studies on albino-rabbits. Ocular irritation study was performed using healthy albino rabbits and confirmed that there was no irritation in the rabbit eyes. All the inserts were found to be uniform thickness and uniform weight. The inserts possessed good tensile strength and percentage elongation. All the formulations followed a first order release pattern. Optimized formulation RSRL3 showed high correlation coefficient (R = 0.996 & 0.995 respectively for dorzolamide HCl & timolol maleate between in vitro and in vivo release. Stability study was carried out on RSRL3 formulation and showed no significant changes in the drug content as well as physical characteristics of the film.

  7. Clinical application of OxyContin hydrochloride controlled release tablets in treatment of pain suffered from advanced cancer

    Institute of Scientific and Technical Information of China (English)

    Wenwu Wang; Xuenong OuYang; Zongyang Yu; Zhangshu Chen

    2012-01-01

    Objective: The aim of this study was to evaluate the efficacy and adverse reactions of OxyContin hydrochloride controlled release tablets in the treatment of moderate or severe pain in patients with terminal cancer and to observe any improvement on the cancer patients' quality of life. Methods: Sixty-eight patients with moderate or severe cancer pain were treated with OxyContin hydrochloride controlled release tablets. The initial dose was 5 mg/12h, or 1/2 that of the standard morphine regimen. During the course of treatment, the dosage was adjusted according to the patients' condition until the pain completely disappeared or nearly did so. Each patient received a treatment for at least 15 days. At the same time, adverse reactions, the quality of life and scores for the intensity of pain were observed and recorded [1]. Results: The final titrated dosage of OxyContin was as follows: the patients in 30 cases (44.1%) received a dosage of ≤ 30 mg/d, those in 16 cases (23.5%) received a dosage of 31 to 60 mg/d, those in 18 cases (26.5%) received a dosage of 61 to 120 mg/d and those in 4 cases (5.9%) received a dosage of ≥ 120 mg/d. The overall rate of relief from pain was 95.6%, among which the rates of excellent, effective and moderate relief were respectively 39.7%, 48.5% and 7.4%. OxyContin had mild adverse reactions and patients' quality of life was markedly improved. Conclusion: OxyContin is effective in treatment of moderate and severe cancer pain. The adverse reactions of OxyContin are mild, and the drug can significantly improve the quality of life of patients with cancer pain.

  8. Randomized clinical trial of tetracycline hydrochloride bandage and paste treatments for resolution of lesions and pain associated with digital dermatitis in dairy cattle.

    Science.gov (United States)

    Cutler, J H Higginson; Cramer, G; Walter, J J; Millman, S T; Kelton, D F

    2013-01-01

    Digital dermatitis is an infectious disease that causes lameness in dairy cattle, a primary welfare concern of the dairy industry. One of the common treatments for this painful hoof disease is through the application of an antibiotic bandage that must be removed following treatment. The objectives of this randomized clinical trial were to determine if topical application of tetracycline hydrochloride in a paste would be as therapeutically effective for the treatment of digital dermatitis as a powdered form of tetracycline hydrochloride held in place by a bandage, and to quantify pain associated with digital dermatitis lesions. Two hundred and fourteen Holstein cow hooves with digital dermatitis lesions were randomly assigned to 1 of 3 treatments: a tetracycline hydrochloride paste, tetracycline hydrochloride powder held in place with a bandage for 2 d, or a negative (untreated) control. Lesions were examined at 2 time periods: 3 to 7 d posttreatment and 8 to 12 d posttreatment to determine healing rates. Nociceptive thresholds were measured using a pressure algometer to quantify the pain at the lesion site. The tetracycline hydrochloride paste was as effective as the powdered bandage treatment in terms of healing rates, with 47.4 and 57.1% hooves healed at 8 to 12 d posttreatment, respectively. Both treatments were more effective than the control, in which no lesions healed 8 to 12 d following initial examination. Mean (±SE) nociceptive thresholds for active, healing, and healed lesions differed, with limb-withdrawal response occurring at 7.45 (±0.67) kg, 12.84 (±1.85) kg, and censored to 25 kg (maximum value of algometer) of force applied, respectively. However, active lesions were not consistently associated with pain, as maximum force was tolerated when applied to 19% of active lesions, perhaps due to variability in stoicism between individual cattle or due to changes in pain during the progression of infection. In conclusion, tetracycline hydrochloride paste

  9. Efficacy and tolerance of repeated oral doses of tolperisone hydrochloride in the treatment of painful reflex muscle spasm: results of a prospective placebo-controlled double-blind trial.

    Science.gov (United States)

    Pratzel, H G; Alken, R G; Ramm, S

    1996-10-01

    The efficacy and safety of oral tolperisone hydrochloride (Mydocalm) in the treatment of painful reflex muscle spasm was assessed in a prospective, randomized, double-blind, placebo-controlled trial. A total of 138 patients, aged between 20 and 75 years, with painful reflex muscle spasm associated with diseases of the spinal column or proximal joints were enrolled in eight rehabilitation centers. Patients were randomized to receive either 300 mg tolperisone hydrochloride or placebo for a period of 21 days. Both treatment groups recovered during the 3 weeks rehabilitation program. However, tolperisone hydrochloride proved to be significantly superior to placebo: the change score of the pressure pain threshold as the primary target parameter significantly increased during therapy with tolperisone hydrochloride (P = 0.03, valid-case-analysis) compared to the results obtained on placebo treatment. The overall assessment of efficacy by the patient also demonstrated significant differences in favor of tolperisone hydrochloride. Best results were seen in patients aged between 40 and 60 years with a history of complaints shorter than 1 year and with concomitant physical therapy. The evaluation of safety data, i.e., adverse events, biochemical and hematological laboratory parameters, demonstrated no differences between tolperisone hydrochloride and placebo. As a conclusion tolperisone hydrochloride represents an effective and safe treatment of painful reflex muscle spasm without the typical side effects of centrally active muscle relaxants.

  10. Does yohimbine hydrochloride facilitate fear extinction in virtual reality treatment of fear of flying? A randomized placebo-controlled trial

    NARCIS (Netherlands)

    Meyerbroeker, K.; Powers, M.B.; van Stegeren, A.; Emmelkamp, P.M.G.

    2012-01-01

    BACKGROUND: Research suggests that yohimbine hydrochloride (YOH), a noradrenaline agonist, can facilitate fear extinction. It is thought that the mechanism of enhanced emotional memory is stimulated through elevated noradrenaline levels. This randomized placebo-controlled trial examined the

  11. Development of a new benazepril hydrochloride chewable tablet and evaluation of its bioequivalence for treatment of heart failure in dogs.

    Science.gov (United States)

    Qian, M; Chen, T; Zhou, D; Zhang, Z; Zhang, Q; Tang, S; Xiao, X

    2016-02-01

    The aim of the study was to develop a new chewable benazepril hydrochloride(BH) tablet, investigate its physical properties, and evaluate its bioequivalence with the branded formulation (Fortekor). A corrective agent was included in the formula to improve its palatability and convenience for administration to dogs. The tablet remained stable in light, heat, and humidity tests, and its physical properties such as hardness, uniformity of content, and dissolution rate were highly consistent with the technical standards. After single and repeated administrations to eight beagles and single dose to 14 mongrel dogs (0.5 mg/kg p.o.), plasma BH and its active metabolite, benazeprilat (BZ), were detected. There was no significant difference in the major pharmacokinetic parameters (Cmax , Tmax, and AUC₀₋₂₄) between the two formulations. The 90% confidence intervals calculated for the ratios of area under the time-concentration curve (AUC₀₋₂₄) were 92.4-116.3% for BH and 89.9-102.3% for BZ, within the accepted range for bioequivalence of 80-125%. The results showed our new chewable tablet is bioequivalent to the commercial product and suitable for addition to the benazepril product family for the treatment of heart failure in dogs.

  12. 丁螺环酮治疗小脑性共济失调%The Treatment of Cerebellar Ataxia with Buspirone Hydrochloride

    Institute of Scientific and Technical Information of China (English)

    邬剑军; 蒋雨平

    2001-01-01

    目的:探讨5-HT1A受体激动剂丁螺环酮改善共济失调症状的作用。方法:应用评分计分法观察丁螺环酮治疗24例共济失调患者3个月。结果:治疗前后共济失调评分,包括稳定性、协调性、构音、眼球运动各方面的差异均有显著意义(P0.05)。结论:丁螺环酮短期内可以有效地改善患者小脑性共济失调的症状。%Aim: To evaluate the efficacy of buspirone hydrochloride, a serotonin (5-hydroxytrypamine1A) agonist, in treating patients with cerebellar ataxia. Methods:Open-table study in which 24 patients received buspimne hydrochloride for three months. Results:All who completed the study showed significant improvement in ataxia rating scale, including stability, coordination, articulation, ocular movement, but not in the Hamilton anxiety scale. Conclusion:Short-term treatment with buspirone hydrochloride can improve the symptoms of patients with cerebellar ataxia.

  13. 盐酸多奈哌齐治疗老年痴呆的临床分析%Clinical Analysis on Donepezil Hydrochloride in Treatment of Senile Dementia

    Institute of Scientific and Technical Information of China (English)

    常嵘

    2015-01-01

    Objective Clinical effect of Donepezil Hydrochloride in treatment of senile dementia was to be studied.Methods Choose 48 elderly patients of senile dementia who are treated in hospital from January 2015 to November 2015 and separated 23 patients into control group that were given conventional treatment, while another 25 patients are taken into study group were given Donepezil Hydrochloride treatment and then observed and compared treatment effects between two groups.Results Patients’ treatment efficacy was much higher and their MMSE and ADL assessment scores were improved much more favorable in study group and patients’ side-effect incidence was much lower compared to that in control group; there was a differential between two groups and such a differential has statistic value(P<0.05). Conclusion Donepezil Hydrochloride was effective in treatment of senile dementia.%目的:分析盐酸多奈哌齐治疗老年痴呆的效果。方法研究2015年1月~2015年11月,纳入老年痴呆共48例,随机分组。常规治疗者有23例,为对照组;盐酸多奈哌齐治疗者有25例,为研究组。对比效果。结果两组中研究组的治疗有效率更高,MMSE和ADL评分改善更明显,不良反应率更低,有显著差异(P<0.05),且具统计学意义。结论盐酸多奈哌齐对老年痴呆治疗效果佳。

  14. Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage.

    Science.gov (United States)

    Enomoto, Yukiko; Yoshimura, Shinichi; Yamada, Kiyofumi; Iwama, Toru

    2010-01-01

    The incidence of convulsion and associated factors were retrospectively analyzed in 23 patients with symptomatic cerebral vasospasm following subarachnoid hemorrhage (SAH) who underwent a total of 31 intra-arterial infusion of fasudil hydrochloride (IAFH) procedures in 49 vessels. Fasudil hydrochloride was administered by superselective infusion via a microcatheter positioned at the proximal portion of the affected artery. Thirteen procedures were performed by manually controlled infusion of 30-75 mg fasudil hydrochloride (1.2-3.75 mg/ml) for approximately 10 minutes. Eighteen procedures were performed by continuous infusion of 60 mg fasudil hydrochloride (1.2 mg/ml) by infusion pump at a constant rate of 3 mg/min. Neurological improvement was observed after 18 of 22 procedures in patients with neurological deterioration due to vasospasm. Convulsion during IAFH developed in 4 patients, all treated by manual infusion (p convulsion during IAFH. IAFH was effective for treating cerebral vasospasm following aneurysmal SAH. IAFH at a constant rate of 3 mg/min delivered by infusion pump improved the symptoms of cerebral vasospasm and prevented convulsions during IAFH.

  15. Anamorelin hydrochloride for the treatment of cancer-anorexia-cachexia in NSCLC.

    Science.gov (United States)

    Zhang, Hongjie; Garcia, Jose M

    2015-06-01

    Cancer anorexia-cachexia syndrome (CACS) is associated with increased morbidity and mortality. Anamorelin is a novel, orally active ghrelin receptor agonist in clinical development for the treatment of CACS in NSCLC. The aim of this review is to summarize preclinical and clinical studies evaluating anamorelin as a potential promising treatment for CACS in NSCLC. Pharmacodynamics, pharmacokinetics and metabolism, clinical efficacy, safety and tolerability of anamorelin for the treatment of CACS in NSCLC were reviewed. Anamorelin administration may lead to increases in food intake, body weight and lean body mass, and a stimulatory effect on growth hormone secretion in NSCLC patients. Anamorelin is well tolerated with no dose-limiting toxicities identified to date. Targeting ghrelin receptors presents the advantage of potentially addressing multiple mechanisms of CACS simultaneously including appetite, muscle protein balance, adipose tissue metabolism, energy expenditure and inflammation. Clinical data suggest that anamorelin is well tolerated and it effectively increases appetite, body weight and lean mass in patients with advanced NSCLC. Long-term safety remains unknown at this time. The potential synergistic effects of anamorelin with nutritional support or exercise as well as its efficacy/safety in other tumor types are also unknown.

  16. Azelastine hydrochloride, a dual-acting anti-inflammatory ophthalmic solution, for treatment of allergic conjunctivitis

    Directory of Open Access Journals (Sweden)

    Patricia B Williams

    2010-09-01

    Full Text Available Patricia B Williams1,2, Elizabeth Crandall2, John D Sheppard1,21Thomas R Lee Center for Ocular Pharmacology, 2Department of Ophthalmology, Eastern Virginia Medical School, Norfolk, A, USAAbstract: Over 50% of patients who seek treatment for allergies present with ocular ­symptoms. Our current ability to control ocular allergic symptoms is greater than ever before. Newer dual-acting topical eyedrops attack multiple facets of the allergic cascade. Azelastine has antihistaminic effects providing immediate relief, mast cell stabilization providing early-phase intervention, and inhibition of expression and activation of anti-inflammatory mediators which characterize the late phase of the immune reaction. The ophthalmic eyedrop formulation is approved for treatment of allergic conjunctivitis in adults and children aged over 3 years. In clinical trials comparing azelastine with other dual-acting eyedrops, such as levocabastine and olopatadine, azelastine was reported to be slightly less efficacious and to sting briefly upon administration. Even so, many patients experienced the full benefit of symptom relief, and preferred azelastine. As a broad-spectrum drug, azelastine offers many desirable properties for management of ocular allergies. Because it can often produce maximal effect with just twice-daily dosing, azelastine is a particularly good choice for the allergic population in whom minimizing exposure to topical products and preservatives is a key concern.Keywords: allergic conjunctivitis, dual acting anti-inflammatory, H1 receptor antagonism, mast cell stabilization, inflammatory mediator inhibition

  17. Cartap Hydrochloride Poisoning.

    Science.gov (United States)

    Kalyaniwala, Kimmin; Abhilash, Kpp; Victor, Peter John

    2016-08-01

    Cartap hydrochloride is a moderately hazardous nereistoxin insecticide that is increasingly used for deliberate self-harm in India. It can cause neuromuscular weakness resulting in respiratory failure. We report a patient with 4% Cartap hydrochloride poisoning who required mechanical ventilation for 36-hours. He recovered without any neurological deficits. We also review literature on Cartap hydrochloride poisoning.

  18. Differential expression on mitochondrial tryparedoxin peroxidase (mTcTXNPx) in Trypanosoma cruzi after ferrocenyl diamine hydrochlorides treatments.

    Science.gov (United States)

    Kohatsu, Andréa A N; Silva, Flávia A J; Francisco, Acácio I; Rimoldi, Aline; Silva, Marco T A; Vargas, Maria D; Rosa, João A da; Cicarelli, Regina M B

    Resistance to benznidazole in certain strains of Trypanosoma cruzi may be caused by the increased production of enzymes that act on the oxidative metabolism, such as mitochondrial tryparedoxin peroxidase which catalyses the reduction of peroxides. This work presents cytotoxicity assays performed with ferrocenyl diamine hydrochlorides in six different strains of T. cruzi epimastigote forms (Y, Bolivia, SI1, SI8, QMII, and SIGR3). The last four strains have been recently isolated from triatominae and mammalian host (domestic cat). The expression of mitochondrial tryparedoxin peroxidase was analyzed by the Western blotting technique using polyclonal antibody anti mitochondrial tryparedoxin peroxidase obtained from a rabbit immunized with the mitochondrial tryparedoxin peroxidase recombinant protein. All the tested ferrocenyl diamine hydrochlorides were more cytotoxic than benznidazole. The expression of the 25.5kDa polypeptide of mitochondrial tryparedoxin peroxidase did not increase in strains that were more resistant to the ferrocenyl compounds (SI8 and SIGR3). In addition, a 58kDa polypeptide was also recognized in all strains. Ferrocenyl diamine hydrochlorides showed trypanocidal activity and the expression of 25.5kDa mitochondrial tryparedoxin peroxidase is not necessarily increased in some T. cruzi strains. Most likely, other mechanisms, in addition to the over expression of this antioxidative enzyme, should be involved in the escape of parasites from cytotoxic oxidant agents. Copyright © 2016 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.

  19. Fibrin glue application in conjunction with tetracycline hydrochloride root conditioning and semilunar coronally repositioned flap in the treatment of gingival recession.

    Science.gov (United States)

    George, Joann Pauline; Prabhuji, M L V; Shaeesta, K B; Lazarus, Flemingson

    2011-01-01

    The purpose of this case report is to present the results of Fibrin Adhesive System (FAS) application, a topical biological tissue adhesive in the treatment of maxillary buccal recessions. A 40-year-old male patient presented with a pair of class I buccal recession defects on maxillary cuspids. Clinical parameters were recorded at baseline, 1 month, and 3 months. Semilunar coronally repositioned flap (Tarnow's technique), root debridement, root conditioning with tetracycline hydrochloride solution and one of the defect was treated with FAS application. Significant recession, height reduction, and attachment gain were observed with the FAS application defect site. About 50% of root coverage was noted in the FAS-treated defect and almost no root coverage in the defect site with no FAS application. Semilunar coronally repositioned flap with FAS application is an effective procedure for root coverage in anterior teeth. The addition of FAS improves the amount of root coverage, especially in relatively shallow defects.

  20. 杜冷丁与盐酸曲马多治疗肾绞痛的疗效对比观察%Dolantin tramadol hydrochloride and the treatment of renal colic compared to observe the effect

    Institute of Scientific and Technical Information of China (English)

    麦海棠

    2009-01-01

    目的 观察杜冷丁和盐酸曲马多对肾绞痛的镇痛效果.方法 将84例肾绞痛患者随机分为杜冷丁组42例,盐酸曲马多组42例,分别给予杜冷丁和盐酸曲马多镇痛.采用VRSs-4和NRS分析两种药物后的镇痛效果,同时观察药物不良反应.结果 杜冷丁组镇痛效果和起效时间优于盐酸曲马多组(Phydrochloride for renal colic pain of the clinical results.Methods 84 cases of renal colic were randomly divided into groups of 42 cases of dolantin,tramadol hydrochloride group of 42 cases,respectively,to give dolantin and analgesic tramadol hydrochloride.Use VRSs-4 and NRS analysis of the two drugs after the analgesic effect of adverse drug reactions observed at the same time.Results Group dolantin analgesic effect and the onset time is better than tramadol hydrochloride group (Phydrochloride and the treat-ment of renal colic have a therapeutic effect,the group is better than dolantin tramadol hydrochloride group,but should pay attention to their adverse reactions.

  1. Efficacy and tolerability of fitostimoline (vaginal cream, ovules, and vaginal washing) and of benzydamine hydrochloride (tantum rosa vaginal cream and vaginal washing) in the topical treatment of symptoms of bacterial vaginosis.

    Science.gov (United States)

    Boselli, F; Petrella, E; Campedelli, A; Muzi, M; Rullo, V; Ascione, L; Papa, R; Saponati, G

    2012-01-01

    Two hundred and 91 patients showing signs and symptoms of bacterial vaginosis (BV) were randomized to receive topical treatment with Fitostimoline (vaginal cream and vaginal ovules + vaginal washing) or benzydamine hydrochloride (vaginal cream + vaginal washing) for 7 days. Signs (leucorrhoea, erythema, oedema, and erosion) and symptoms (burning, pain, itching, vaginal dryness, dyspareunia, and dysuria) (scored 0-3) were evaluated at baseline and at the end of treatment; the total symptoms score (TSS) was also calculated. In 125 patients, a bacterial vaginosis was confirmed by vaginal swab test. The primary efficacy variable analysis, that is, the percentage of patients with therapeutic success (almost complete disappearance of signs and symptoms), demonstrated that Fitostimoline ovules and vaginal cream were therapeutically equivalent and that pooled Fitostimoline treatment was not inferior to benzydamine hydrochloride. All the treatments were well tolerated, with only minor local adverse events infrequently reported. The results of this study confirmed that gynaecological Fitostimoline is a safe and effective topical treatment for BV.

  2. Relationship between results of in vitro susceptibility tests and outcomes following treatment with pirlimycin hydrochloride in cows with subclinical mastitis associated with gram-positive pathogens.

    Science.gov (United States)

    Apparao, Dhananjay; Oliveira, Leane; Ruegg, Pamela L

    2009-06-01

    To determine the association between results of in vitro antimicrobial susceptibility tests and outcomes in cows that received intramammary treatment with pirlimycin hydrochloride for subclinical mastitis associated with gram-positive pathogens. Case-control study. 132 dairy cows (178 mammary glands with subclinical mastitis caused by 194 pathogen isolates). Cows with positive results for a California mastitis test (CMT) were assigned to receive 50 mg of pirlimycin via intramammary administration into each CMT-positive mammary gland every 24 hours for 2 consecutive days or no treatment. Duplicate milk samples were collected before treatment and approximately 21 days later. Target pathogens included coagulase-negative Staphylococcus spp (n = 118 isolates), Streptococcus spp (28), Staphylococcus aureus (7), and other gram-positive cocci (30). Antimicrobial susceptibilities were determined via broth microdilution. Overall treatment success rate was 66% (128/194) for both groups. In vitro resistance to pirlimycin ranged from 0% (0/7 isolates of S aureus) to 50% (13/26 isolates of other gram-positive cocci). For the treated group, 62 of 94 (66%) target pathogens were classified as treatment successes and 32 (34%) were classified as failures. Similarly for the control group, 66 of 100 (66%) target pathogens were classified as treatment successes, whereas 34 (34%) were classified as failures. Many target pathogens from cows with subclinical mastitis were eliminated without treatment, and treatment with pirlimycin did not improve the treatment success rate. Results of in vitro antimicrobial susceptibility tests were not useful as predictors of treatment success following intramammary treatment with pirlimycin.

  3. Efficacy and Tolerability of Fitostimoline (Vaginal Cream, Ovules, and Vaginal Washing) and of Benzydamine Hydrochloride (Tantum Rosa Vaginal Cream and Vaginal Washing) in the Topical Treatment of Symptoms of Bacterial Vaginosis

    OpenAIRE

    Papa, R; Ascione, L.; Rullo, V.; Campedelli, A; Muzi, M.; Petrella, E.; Boselli, F.; Saponati, G.

    2012-01-01

    Two hundred and 91 patients showing signs and symptoms of bacterial vaginosis (BV) were randomized to receive topical treatment with Fitostimoline (vaginal cream and vaginal ovules + vaginal washing) or benzydamine hydrochloride (vaginal cream + vaginal washing) for 7 days. Signs (leucorrhoea, erythema, oedema, and erosion) and symptoms (burning, pain, itching, vaginal dryness, dyspareunia, and dysuria) (scored 0–3) were evaluated at baseline and at the end of treatment; the total symptoms sc...

  4. 大剂量盐酸羟考酮治疗癌痛临床观察%Clinical Observation of Large Dose of Oxycodone Hydrochloride for the Treatment of Cancer Pain

    Institute of Scientific and Technical Information of China (English)

    李绍毅; 原玉霞; 赵红丹; 张丽慧

    2015-01-01

    目的:观察大剂量盐酸羟考酮对晚期癌症患者的镇痛效果和不良反应以及对生活质量的影响。方法通过自身对照试验,对应用大剂量盐酸羟考酮治疗的重度癌痛患者,评价疼痛程度、疼痛缓解率、不良反应及生活质量。结果应用大剂量盐酸羟考酮疼痛缓解率为95%。患者生活质量较前提高。结论大剂量盐酸羟考酮值得临床作为第三阶梯止痛药。%Objective To observe the large dose of oxycodone hydrochloride analgesic effect and adverse reaction in patients with advanced cancer and its influence on quality of life. MethodsThrough contrast test, the application of large dose of oxycodone hydrochloride treatment in patients with severe pain, evaluation of the degree of pain, pain remission rate, adverse reaction and quality of life.Results High doses of oxycodone hydrochloride pain relief rate was 95%. Patients quality of life than before.Conclusion Large dose of oxycodone hydrochloride is wort h clinical application as a third ladder painkillers.

  5. 盐酸利托君治疗先兆早产60例临床分析%Clinical Analysis of Ritodrine Hydrochloride in the Treatment of 60 Cases with Threatenedpremature Labor

    Institute of Scientific and Technical Information of China (English)

    义琴

    2013-01-01

    Objective To analyze the clinical effect of ritodrine hydrochloride in the treatment of threatened premature labor. Methods 60 cases with threatened preterm labor treated with ritodrine hydrochloride and 50 cases with threatened preterm labor treated with magnesium sulfate were retrospectively analyzed.The effective time,prolonging of the gestational age,pregnancy outcome and adverse drug reactions were compared between the two groups.Results The group treated with ritodrine hydrochloride got faster onset of action.The effect of prolonging the days of pregnancy,improving pregnancy outcome of the group treated with ritodrine hydrochloride was significantly better than the group treated with magnesium sulfate. The physical condition of the neonatals in the group treated with ritodrine hydrochloride was improving.In addition the adverse drug reaction rates decreased.Conclusion Ritodrine hydrochloride caninhibit uterine contractions strongly,quickly,successfully, safely and effectively.Ritodrine hydrochloride can be used as the drug of choice for the treatment of threatened premature labor.%目的:分析讨论盐酸利托君治疗先兆早产的临床效果。方法对60例使用盐酸利托君和50例使用硫酸镁的先兆早产患者进行回顾性分析,对患者用药后的显效时间、延长妊娠天数、妊娠结局、药物副反应进行比较。结果盐酸利托君组保胎起效时间快、延长妊娠天数、改善妊娠结局均显著高于硫酸镁组。盐酸利托君组新生儿状况改善,不良反应率下降。结论盐酸利托君抑制宫缩作用强,显效快,成功率较高,安全有效,可作为目前治疗先兆早产的首选药物。

  6. 高压氧联合盐酸多奈哌齐治疗卒中后认知功能障碍%Hyperbaric Oxygen Combined with Donepezil Hydrochloride in the Treatment of Post-Stroke Cognitive Impair-ment

    Institute of Scientific and Technical Information of China (English)

    许颖; 杨坚; 高宁沁; 陈小平

    2015-01-01

    目的:分析高压氧联合盐酸多奈哌齐对卒中后认知功能障碍的疗效。方法:将90例住院治疗的卒中后认知功能障碍患者分为高压氧联合盐酸多奈哌齐10 mg组、盐酸多奈哌齐10 mg组、盐酸多奈哌齐5 mg组,每组各30例。采用简易精神状态量表(MMSE)及日常生活能力量表(ADL)评价3组患者治疗前后的认知功能。结果:高压氧联合盐酸多奈哌齐10 mg组患者治疗后MMSE和ADL评分较单用盐酸多奈哌齐组明显增加,差异有统计学意义(P<0.01)。结论:高压氧联合盐酸多奈哌齐(10 mg )对卒中后伴认知功能障碍患者的疗效较好。%Objective:To analyze the efficacy of hyperbaric oxygen combined with donepezil hydrochloride on post‐stroke cogni‐tive impairment .Methods:Ninety hospitalized patients with post‐stroke cognitive impairment were selected .They were divided into hyperbaric oxygen combined with donepezil hydrochloride 10 mg group ,donepezil hydrochloride 10 mg group and donepezil hydrochloride 5 mg group ,with 30 cases in each group .Cognitive functions in 3 groups before and after the treatment were e‐valuated with the mini mental state examination (MMSE) and the ability of daily living scale (ADL) .Results:The scores of MMSE and ADL of patients in hyperbaric oxygen combined with donepezil hydrochloride 10 mg group increased more than those in donepezil hydrochloride groups after treatment ,and the differences were statistically significant (P<0 .01) .Conclu‐sions:Hyperbaric oxygen combined with donepezil hydrochloride 10 mg shows superior efficacy on post‐stroke patients accom‐panied by cognitive impairment .

  7. Development and characterization of sustain release gastro retentive floating microsphere of diltiazem hydrochloride for the treatment of hypertension

    Directory of Open Access Journals (Sweden)

    Mangal S Panwar

    2015-01-01

    Full Text Available Gastroretentive drug delivery systems are the systems, which are retained in the stomach for a longer period and thereby improve the bio-availability of drugs. Diltiazem hydrochloride (DTZ HCl, is a calcium channel blocker, an antihypertension and antianginal drug, DTZ HCl undergoes an extensive biotransformation, mainly through cytochrome P-450 CYP3A, which results in <4% of its oral dose being excreted unchanged in urine. Suffers from poor bio-availability (~30-40% owing to an important first pass metabolism. It has an elimination half-life of 3.5 h and an absorption zone from the upper intestinal tract. Thus, the present work is aimed to formulate sustain release floating microsphere of DTZ HCl for gastroretentive drug delivery system. Floating microsphere were prepared using nonaqueous solvent evaporation method using polycarbonate, chitosan, ethyl cellulose, hydroxypropyl methycellulose and acrycoat as materials in various quantities, in varying ratio to formulate 20 formulations of the floating microsphere. Observations of all formulations for physical characterization had shown that, all of them comply with the specification of official pharmacopoeias and/or standard reference. It was observed that microsphere of batch F3 followed the results obtained, it was concluded that the formulation 98.72% F3 is the best formulations as the extent of drug release was found to be around 99.81% at the desired time 12 h.

  8. Anamorelin hydrochloride in the treatment of cancer anorexia–cachexia syndrome: design, development, and potential place in therapy

    Directory of Open Access Journals (Sweden)

    Graf SA

    2017-08-01

    Full Text Available Solomon A Graf,1–3 Jose M Garcia4,5 1Veterans Affairs Puget Sound Health Care System, 2Department of Medicine, Division of Medical Oncology, University of Washington School of Medicine, 3Clinical Research Division, Fred Hutchinson Cancer Research Center, 4Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 5Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Seattle, WA, USA Abstract: Cancer anorexia–cachexia syndrome (CACS is a complex and largely untreatable paraneoplastic complication common in advanced cancer. It is associated with profoundly deleterious effects on quality of life and survival. Since its discovery over a decade ago, anamorelin hydrochloride (anamorelin, a mimetic of the growth hormone secretagogue ghrelin, has shown considerable promise in ameliorating components of CACS when administered to patients with advanced cancer, including loss of lean body mass and reversal of anorexia. This review summarizes the development of anamorelin and its safety and efficacy in clinical investigations. The potential future role of anamorelin in treating CACS is also discussed. Keywords: anamorelin, cachexia, anorexia, ghrelin, non-small cell lung cancer

  9. Trifluridine and Tipiracil Hydrochloride

    Science.gov (United States)

    This page contains brief information about trifluridine and tipiracil hydrochloride and a collection of links to more information about the use of this combination drug, research results, and ongoing clinical trials.

  10. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells.

    Science.gov (United States)

    Jo, Jeong-Rang; Park, Yu-Kyoung; Jang, Byeong-Churl

    2014-05-01

    Hypoxia-inducible factor-1 (HIF-1) is a tumor angiogenic transcription factor composed of an α and β subunit. We investigated the effect of glucosamine hydrochloride (GS-HCl) on the expression of HIF-1α and HIF-1β in serum‑treated YD-8 human tongue cancer cells. While long-term (24 h) treatment with GS-HCl strongly repressed the expression of HIF-1α and HIF-1β at both the protein and mRNA levels, short-term (4 h) GS-HCl treatment inhibited HIF-1α at the protein level. Short-term GS-HCl treatment also decreased phosphorylation of p70S6K and S6, translation-related proteins. However, the results of subsequent pharmacological inhibition and protein stability analyses indicated that HIF-1α protein downregulation induced by short-term GS-HCl treatment was not through modulation of the mTOR/p70S6K/S6 signaling pathways, the 26S proteasomal and lysosomal activities and HIF-1α protein stability. Importantly, our further analyses identified that HIF-1α protein downregulation induced by short-term GS-HCl treatment was blunted by exogenous administration of the citric acid cycle metabolites citrate and 2-oxoglutarate, but not the glycolytic end byproducts pyruvate and lactate. These findings demonstrate firstly that short-term GS treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites. It is proposed that short-term GS-HCl exposure may be applied for the treatment of oral tumors with high expression of HIF-1α.

  11. Noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4), treatment eliminates estrogenic effects on song responsiveness in female zebra finches (Taeniopygia guttata).

    Science.gov (United States)

    Vyas, Akshat; Harding, Cheryl; McGowan, Joseph; Snare, Randall; Bogdan, Diane

    2008-10-01

    Female songbirds use male songs as an important criterion for mate selection. Several studies have reported that female songbirds prefer complex songs to other song types. In a recent study, the authors found that song responsiveness in female zebra finches (Taeniopygia guttata) is strongly modulated by circulating estrogen levels. The behavioral effects of estrogen are often mediated via norepinephrine (NE). The current study administered the noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4) to estradiol-treated female zebra finches to investigate if estrogenic effects on song responsiveness are mediated via NE. The authors tested song responsiveness of adult female zebra finches for three acoustically different song types--simple, long-bout, and complex--under three treatment conditions, untreated, estradiol-treated, and estradiol + DSP-4-treated. Females only showed differential song responsiveness when treated with estradiol alone, responding more to complex songs. DSP-4 treatment eliminated this differential responsiveness. The results are discussed in the light of evidence from functional, neurochemical, and neuroanatomical studies that suggest that estrogenic effects on song processing might be mediated by NE.

  12. Design and In Vitro Haemolytic Evaluation of Cryptolepine Hydrochloride-Loaded Gelatine Nanoparticles as a Novel Approach for the Treatment of Malaria

    OpenAIRE

    Kuntworbe, Noble; AL-KASSAS, RAIDA

    2012-01-01

    Cryptolepine hydrochloride-loaded gelatine nanoparticles were developed and characterised as a means of exploring formulation techniques to improve the pharmaceutic profile of the compound. Cryptolepine hydrochloride-loaded gelatine-type (A) nanoparticles were developed base on the double desolvation approach. After optimisation of formulation parameters including temperature, stirring rate, incubation time polymer and cross-linker (glutaraldehyde) concentrations, the rest of the study was co...

  13. Two Years of Cinacalcet Hydrochloride Treatment Decreased Parathyroid Gland Volume and Serum Parathyroid Hormone Level in Hemodialysis Patients With Advanced Secondary Hyperparathyroidism.

    Science.gov (United States)

    Yamada, Shunsuke; Tokumoto, Masanori; Taniguchi, Masatomo; Toyonaga, Jiro; Suehiro, Takaichi; Eriguchi, Rieko; Fujimi, Satoru; Ooboshi, Hiroaki; Kitazono, Takanari; Tsuruya, Kazuhiko

    2015-08-01

    The long-term effect of cinacalcet hydrochloride treatment on parathyroid gland (PTG) volume has been scarcely investigated in patients with moderate to advanced secondary hyperparathyroidism (SHPT). The present study was a prospective observational study to determine the effect of cinacalcet treatment on PTG volume and serum biochemical parameters in 60 patients with renal SHPT, already treated with intravenous vitamin D receptor activator (VDRA). Measurement of biochemical parameters and PTG volumes were performed periodically, which were analyzed by stratification into tertiles across the baseline parathyroid hormone (PTH) level or PTG volume. We also determined the factors that can estimate the changes in PTG volume and the achievement of the target PTH range by multivariable analyses. Two years of cinacalcet treatment significantly decreased the serum levels of PTH, calcium, and phosphate, followed by the improvement of achieving the target ranges for these parameters recommended by the Japanese Society for Dialysis Therapy. Cinacalcet decreased the maximal and total PTG volume by about 30%, and also decreased the serum PTH level independent of the baseline serum PTH level and PTG volume. Ten out of 60 patients showed 30% increase in maximal PTG after 2 years. Multivariable analysis showed that patients with nodular PTG at baseline and patients with higher serum calcium and PTH levels at 1 year were likely to exceed the target range of PTH at two years. In conclusion, cinacalcet treatment with intravenous VDRA therapy decreased both PTG volume and serum intact PTH level, irrespective of the pretreatment PTG status and past treatment history. © 2015 The Authors. Therapeutic Apheresis and Dialysis © 2015 International Society for Apheresis.

  14. XLGB Capsule Combined with Glucosamine Hydrochloride Tablets in the Treatment of Knee Osteoarthritis 60 Cases%仙灵骨葆胶囊联合盐酸氨基葡萄糖片治疗膝骨性关节炎

    Institute of Scientific and Technical Information of China (English)

    韩国栋; 蒋再轶; 谭洁; 彭芝配

    2011-01-01

    目的:观察仙灵骨葆胶囊联合盐酸氨基葡萄糖片治疗膝骨性关节炎的临床疗效.方法:将60例患者随机分为治疗组与对照组,治疗组仙灵骨葆胶囊+盐酸氨基葡萄糖片口服(仙灵骨葆胶囊,3粒/次,2次/d;盐酸氨基葡萄糖片,480 mg/次,3次/d),对照组盐酸氨基葡萄糖片口服(480 mg/次,3次/d),8周为1个疗程.结果:治疗组有效率89.3%,对照组为71.9%,两组差异显著(P<0.05);两组治疗后疼痛缓解时间比较,差异显著(P<0.05).结论:仙灵骨葆胶囊联合盐酸氨基葡萄糖片治疗膝骨性关节炎疗效明显,且能够缩短关节疼痛时间.%Objective: To observe the joint Xiangling Cubao ( XLCB ) capsules with glucosamine hydrochloride tablets in the treatment of knee osteoarthritis. Method; Sixty patients were randomly divided into treatment group and control group, treatment group received XLCB capsules + glucosamine hydrochloride tablet(XLCB capsules, 3 capsules, 2 twice daily + glucosamine hydrochloride tablets, 480 mg, 3 times daily) , the control group received glucosamine hydrochloride tablet (480 mg, 3 times daily) , 8 weeks for a course of treatment. Result: The treatment group' s effective rate was 89.3% , the control group rate was 71.9% , the difference was statistically significant ( P < 0. 05) , Comparing the pain relief time after treatment, the difference was statistically significant ( P < 0. 05 ) . Conclusion: XLCB capsule combined with glucosamine hydrochloride tablets in the treatment of knee osteoarthritis shows efficacy significantly, joint pain can be shortened.

  15. Evaluation of eperisone hydrochloride in the treatment of acute musculoskeletal spasm associated with low back pain: A randomized, double-blind, placebo-controlled trial

    Directory of Open Access Journals (Sweden)

    A S Chandanwale

    2011-01-01

    . Conclusions : Eperisone hydrochloride was effective and well tolerated for the treatment of patients with AMSP with LBP.

  16. Clinical Study on Hydrochloride Ambroxol Oral Medication Treatment of Bronchitis%盐酸氨溴索口服液治疗支气管炎的临床探析

    Institute of Scientific and Technical Information of China (English)

    巩哜萍

    2015-01-01

    Objective Clinical effect of hydrochloride ambroxol oral medication treatment of bronchitis is to be investigated. Methods Choose 108 bronchitis patients who are treated in hospital from October 2013 to June 2014 and separate them into control group and study group according to random number table; patients in control group are given bromhexine medication treatment,while patients in study group are given hydrochloride ambroxol oral medication treatment and then compare treatment effects between two groups. Results Treatment effect in study group is much more favorable than that in control group; there is a treatment differential between two groups,and such a differential has statistic value(P<0.05). Conclusion Hydrochloride ambroxol oral medication is of efficacy in treatment of bronchitis; such a treatment approach is quite worthwhile to be promoted and applied clinical y.%目的:对盐酸氨溴索口服液治疗支气管炎的临床效果进行探究。方法选取于2013年10月~2014年6月收治的108例支气管炎患者,采用随机数字表法分为对照组和观察组,对照组患者给予溴己新治疗,观察组患者给予盐酸氨溴索口服液治疗,对两组患者治疗效果进行对比分析。结果观察组的治疗效果明显优于对照组,差异有统计学意义(P<0.05)。结论使用盐酸氨溴索口服液治疗支气管炎效果较为显著,值得在临床实践中推广使用。

  17. 生长调节剂PCPA和2,4-D对番茄果实果糖激酶活性及基因表达的影响%EFFECTS OF EXOGENOUS PCPA AND 2,4-D ON ACTIVITY OF FRUCTOKINASE AND GENE EXPRESSION IN TOMATO FRUITS

    Institute of Scientific and Technical Information of China (English)

    史宝中; 王卫平; 崔娜; 董雪飞; 李天来

    2011-01-01

    研究了花期施用PCPA和2,4-D对发育过程中番茄果实糖含量、蔗糖代谢相关酶和果糖激酶活性及果糖激酶基因表达的影响。结果表明,随着番茄果实的发育,果糖激酶的活性及其基因表达均先上升后下降,成熟时达到最低,但FRK1基因表达量较高;果糖和葡萄糖含量呈递增的趋势,成熟时含量达到最高。PCPA和2,4-D处理后降低了成熟番茄果实果糖激酶活性,提高了酸性转化酶活性,促进了FRK1基因表达,提高了成熟番茄果实中果糖和葡萄糖的含量。%Sugar contents,enzyme activities related to sucrose metabolism and fructokinase(FRK),fructokinase gene expression were studied during tomato fruit development after PCPA and 2,4-D treatment,respectively.Results showed that activity and gene expression of fructokinase increased at first then decreased during fruit development in control.Fructokinase activity reached the lowest level,but FRK1 gene expression showed a higher level during fruit ripening stage.However,the contents of fructose and glucose in fruit reached the peak value at the maturity stage.The fructokinase activity declined,while the activity of acid invertase was increased went up.At the same time gene expression of fructokinase was enhanced during fruit maturing stage after treated with PCPA and 2,4-D,which made the contents of fructose and glucose increased.

  18. Clinical Analysis of Ambroxol Hydrochloride in Treatment of Chronic Bronchitis%盐酸氨溴索治疗慢性支气管炎的效果观察

    Institute of Scientific and Technical Information of China (English)

    张香平

    2015-01-01

    Objective Treatment and efficacy of ambroxol hydrochloride medicine in treatment of chronic bronchitis are to be investigated. Methods Chose 35 chronic bronchitis patients who are treated in hospital from July 2013 to November 2014 and separate them into study group and control group at random. 19 patients in study group were given ambroxol hydrochloride medicine treatment,while 16 patients in control group were given brombexine hydrochloride treatment,and then observed and compared treatment efficacy of the two groups. Results The result showed that the treatment efficacy in study group was 94.74%,while the treatment efficacy in control group was 75.0%,there was a treatment efficacy differential between the two groups,and such a differential had statistic value(P<0.05). Conclusion Ambroxol hydrochloride treatment is beneficial to relieve patients’symptoms of cough and asthma and improve their comfort feeling.%目的:探究慢性支气管患者采用盐酸氨溴索治疗的方法和效果。方法选取2013年7月~2014年11月收治的35例慢性支气管炎患者进行治疗,随机分组,实验组19例患者采用盐酸氨溴索,对照组16例患者选择必嗽平的治疗,观察两组患者的治疗效果。结果实验组患者治疗有效率为94.74%,对照组患者治疗有效率为75.0%。两组患者的治疗效果差异有统计学意义(P<0.05)。结论慢性支气管炎患者采用盐酸氨溴索的使用,能够缓解咳嗽、气喘等不良症状,提高身体舒适度。

  19. 调神针法配合黛力新治疗脑卒中后抑郁疗效观察%Observation of Therapeutic Effect of Acupuncture Treatment Combined with Fluoxetine hydrochloride Intake for Treating Post-stroke Depression

    Institute of Scientific and Technical Information of China (English)

    黄捷; 王占强; 高青青; 时婧; 李宝栋; 张世亮; 王宁宁; 于文武; 孙维明; 孙喜凤; 王海霞; 刘林林

    2015-01-01

    Objective:To observe the effect of acupuncture on patients with post stroke depression.Methods:A total of 90 pa-tients were randomly divided into combined treatment group,acupuncture group,fluoxetine hydrochloride group and there were 30 cases in each group.The acupuncture group received acupuncture treatment on Baihui,Fengfu,Shenting,Shuigou,Dazhui, Shendao and other acupoints,once a day,5 times a week.Fluoxetine hydrochloride group was given fluoxetine hydrochloride,3 tablets each time,3 times daily.Comprehensive group receive treatment combined acupuncture and fluoxetine hydrochloride.All of three groups received treatment for 3 weeks of a course,a total of 6 courses of treatment.The clinical efficacy,Hamilton De-pression Rating Scale(HAMD)score,and the adverse reactions were compared in the three groups.Results:The total efficiency rate of the comprehensive group was 96.7%(29 /30),better than acupuncture group of 83.3%(25 /30)and fluoxetine hydro-chloride group 80.0%(24 /30).The HAMD scores in 3 groups was significantly reduced(P 0.05) and after treatment of 24 weeks,the acupuncture group’s HAMD score became lower than fluoxetine hydrochloride group(P <0.05).There were 2 cases of adverse reactions in the comprehensive group,6 cases in fluoxetine hydrochloride group,and acu-puncture group had no cases showing adverse reactions.Conclusion:Acupuncture treatment combined with oral Deanxit treatment has better clinical efficacy than only oral fluoxetine hydrochloride treatment or just acupuncture treatment.Acupuncture treatment while had no significant difference comparing to fluoxetine hydrochloride treatment in clinical curative effect,but long-term HAMD score and safety is superior to fluoxetine hydrochloride treatment.%目的:观察调神针法对脑卒中后抑郁患者疗效的影响。方法:将90例患者按随机数字表法随机分为综合组、调神针法组、黛力新组,每组30例。调神针法组采用调神针法治疗,选用百会、

  20. 莫西沙星联合盐酸氨溴索治疗慢性支气管炎的效果研究%Effect on Moxifloxacin Combined With Ambroxol Hydrochloride in Treatment of Chronic Bronchitis

    Institute of Scientific and Technical Information of China (English)

    高俊耀

    2016-01-01

    目的:研究莫西沙星联合盐酸氨溴索对慢性支气管炎的治疗效果。方法研究2015年1~10月慢性支气管炎患者66例,依照数字法分组。采用常规疗法者33例,进入对照组;采用莫西沙星联合盐酸氨溴索者33例,进入实验组。组间比较。结果两组中实验组的咳痰、咳嗽及喘息消失时间更短,住院日更短,治疗有效率更高,差异有统计学意义(P<0.05)。结论莫西沙星联合盐酸氨溴索治疗慢性支气管炎效果较佳。%Objective Moxifloxacin combined with ambroxol hydrochloride effect in treatment of chronic bronchitis is to be studied. Methods Chose 66 patients of chronic bronchitis who were treated in hospital from January 2015 to October 2015 and separated them into two groups according to digits. 33 patients in control group were given conventional treatment,while another 33 patients in study group were given moxifloxacin combined with ambroxol hydrochloride treatment and then compared treatment effects between two groups. Results Patients’symptoms disappeared time of sputum,cough and wheezing is shorter and treatment efficacy was higher in study group compared to counterparts in control group,there was a differential between two groups and such a differential has statistic value(P<0.05). Conclusion Moxifloxacin combined with ambroxol Hydrochloride is quite effective in treatment of chronic bronchitis.

  1. Vaccination with a Streptococcus pneumoniae trivalent recombinant PcpA, PhtD and PlyD1 protein vaccine candidate protects against lethal pneumonia in an infant murine model.

    Science.gov (United States)

    Verhoeven, David; Xu, Qingfu; Pichichero, Michael E

    2014-05-30

    Streptococcus pneumoniae infections continue to cause significant worldwide morbidity and mortality despite the availability of efficacious serotype-dependent vaccines. The need to incorporate emergent strains expressing additional serotypes into pneumococcal polysaccharide conjugate vaccines has led to an identified need for a pneumococcal protein-based vaccine effective against a broad scope of serotypes. A vaccine consisting of several conserved proteins with different functions during pathogenesis would be preferred. Here, we investigated the efficacy of a trivalent recombinant protein vaccine containing pneumococcal choline-binding protein A (PcpA), pneumococcal histidine triad D (PhtD), and genetically detoxified pneumolysin (PlyD1) in an infant mouse model. We found the trivalent vaccine conferred protection from lethal pneumonia challenges using serotypes 6A and 3. The observed protection with trivalent PcpA, PhtD, and PlyD1 vaccine in infant mice supports the ongoing study of this candidate vaccine in human infant clinical trials.

  2. 氨酚羟考酮和盐酸曲马多治疗癌性疼痛的疗效比较%Effect Comparison of Oxycodone Acetaminophen and Tramadol Hydrochloride in the Treatment of Cancer Pain

    Institute of Scientific and Technical Information of China (English)

    王志坚; 朵珍

    2016-01-01

    目的:比较氨酚羟考酮和盐酸曲马多治疗癌性疼痛的效果。方法通过氨酚羟考酮(A组)每6 h口服1片,盐酸曲马多(B组)每12h口服1片,比较两组在治疗24h后的临床疗效以及治疗1d、2d、3 d、7 d、21 d NRS评分值。结果A组和B组在治疗24 h后临床有效率分别为86.84%和73.33%,在1 d、2 d、3 d、7 d、21 d不同时间点NRS评分两种药物差异有统计学意义,P<0.05。结论氨酚羟考酮在治疗癌性疼痛效果方面优于盐酸曲马多。%Objective Comparison of tylox and tramadol hydrochloride in treatment of cancer pain. Methods By acetaminophen oxycodone (group A) oral 1 piece every 6 hours, tramadol hydrochloride (group B) oral 1 tablet every 12 hours of observation, comparison in 24 h after treatment the clinical curative effect and treatment of 1 d, 2 d, 3 d, 7 d, 21 d of NRS score values. Results Group A and group B in the treatment of clinical effectiveness were 86.84% and 73.33% respectively after 24 h, in 1 d, 2 d, 3 d, 7 d, 21 d different NRS score two drugs have signiifcant differences, P<0.05. Conclusion Acetaminophen oxycodone in the treatment of cancer pain is better than that of tramadol hydrochloride.

  3. 倍他司汀联合盐酸氟桂利嗪治疗耳鸣患者的疗效观察%Efficacy observation of Betahistine combined with Flunarizine hydrochloride in treatment of tinnitus

    Institute of Scientific and Technical Information of China (English)

    林小龙

    2015-01-01

    目的::观察倍他司汀联合盐酸氟桂利嗪治疗耳鸣患者的临床疗效。方法:选取100例耳鸣患者,根据随机数字表法分为对照组与观察组,每组各50例,对照组患者单纯服用盐酸氟桂利嗪,观察组患者则采用盐酸氟桂利嗪与倍他司汀联合治疗,观察两组患者耳鸣程度、听力状况以及用药不良反应情况,并对研究结果相关数据作统计学处理。结果:与对照组相比,观察组患者治疗总有效率更高,耳鸣程度以及听力情况改善更优,组间差异有统计学意义(P0.05)。结论:倍他司汀联合盐酸氟桂利嗪方案治疗耳鸣患者的效果确切,可有效改善患者听力以及耳鸣症状,疗效更优于单用盐酸氟桂利嗪,值得临床推广使用。%Objective:To observe clinical efficacy of Betahistine hydrochloride combined with Flunarizine in treatment of tinni-tus. Methods:According to the random number table method, one hundred tinnitus patients were divided into control group and obser-vation group, 50 cases in each group. The control group was only treated with Flunarizine hydrochloride, while the observation group used Flunarizine hydrochloride combined with Betahistine. The degree of tinnitus, hearing status and adverse drug reactions of the two groups were observed, and the relevant data of the results of the study were analyzed statistically. Results: Compared with control group, the total effective rate of observation group was higher, and the degree of tinnitus and hearing status were improved better, and the differences were statistically significant (P0. 05). Conclusions:Betahistine combined with Flunarizine hydrochloride in treatment of tinnitus has an exact effect, can effectively improve the patient's hearing and tinnitus symptoms, is more effective than single Flunarizine hydrochlo-ride, and is worthy of clinical use.

  4. Profile of trifluridine/tipiracil hydrochloride in the treatment of metastatic colorectal cancer: efficacy, safety, and place in therapy

    Directory of Open Access Journals (Sweden)

    Sunakawa Y

    2017-09-01

    Full Text Available Yu Sunakawa, Naoki Izawa, Takuro Mizukami, Yoshiki Horie, Mami Hirakawa, Hiroyuki Arai, Takashi Ogura, Takashi Tsuda, Takako Eguchi Nakajima Department of Clinical Oncology, St Marianna University School of Medicine, Kawasaki, Japan Abstract: TAS-102, with its robust survival efficacy and feasible toxicity, is one of the standard salvage-line treatments for patients with metastatic colorectal cancer (mCRC. No definitive data are available to determine which drug should be administered first during salvage-line treatment. Therefore, it is imperative that we establish the sequence of administration by considering drug toxicity profiles based on patient characteristics, such as age, performance status, comorbidities, tolerability to previous treatments, and patient preferences. The identification of predictive biomarkers in response to TAS-102 or its toxicity is urgently needed for better patient selection. Moreover, to strengthen efficacy or relieve toxicity, combinations with other agents, which could potentially emerge as standard treatment regimens, have been investigated and compared to existing active regimens for mCRC. Keywords: TAS-102, metastatic colorectal cancer, regorafenib, biomarker

  5. Cartap hydrochloride poisoning: A clinical experience

    Directory of Open Access Journals (Sweden)

    Hari K Boorugu

    2012-01-01

    Full Text Available Cartap hydrochloride, a nereistoxin analog, is a commonly used low toxicity insecticide. We describe a patient who presented to the emergency department with alleged history of ingestion of Cartap hydrochloride as an act of deliberate self-harm. The patient was managed conservatively. To our knowledge this is the first case report of Cartap hydrochloride suicidal poisoning. Cartap toxicity has been considered to be minimal, but a number of animal models have shown significant neuromuscular toxicity resulting in respiratory failure. It is hypothesized that the primary effect of Cartap hydrochloride is through inhibition of the [ 3 H]-ryanodine binding to the Ca 2+ release channel in the sarcoplasmic reticulum in a dose-dependent manner and promotion of extracellular Ca 2+ influx and induction of internal Ca 2+ release. This results in tonic diaphragmatic contraction rather than paralysis. This is the basis of the clinical presentation of acute Cartap poisoning as well as the treatment with chelators namely British Anti Lewisite and sodium dimercaptopropane sulfonate.

  6. Cartap hydrochloride poisoning: A clinical experience.

    Science.gov (United States)

    Boorugu, Hari K; Chrispal, Anugrah

    2012-01-01

    Cartap hydrochloride, a nereistoxin analog, is a commonly used low toxicity insecticide. We describe a patient who presented to the emergency department with alleged history of ingestion of Cartap hydrochloride as an act of deliberate self-harm. The patient was managed conservatively. To our knowledge this is the first case report of Cartap hydrochloride suicidal poisoning. Cartap toxicity has been considered to be minimal, but a number of animal models have shown significant neuromuscular toxicity resulting in respiratory failure. It is hypothesized that the primary effect of Cartap hydrochloride is through inhibition of the [(3)H]-ryanodine binding to the Ca(2+) release channel in the sarcoplasmic reticulum in a dose-dependent manner and promotion of extracellular Ca(2+) influx and induction of internal Ca(2+) release. This results in tonic diaphragmatic contraction rather than paralysis. This is the basis of the clinical presentation of acute Cartap poisoning as well as the treatment with chelators namely British Anti Lewisite and sodium dimercaptopropane sulfonate.

  7. Clinical Analysis on the Treatment of Peptic Ulcer by Ranitidine Hydrochloride Tablets Combine Omeprazole Sodium for Injection%雷尼替丁联合奥美拉唑治疗消化性溃疡的临床研究

    Institute of Scientific and Technical Information of China (English)

    孙晓春

    2015-01-01

    目的:探究消化性溃疡患者采用雷尼替丁联合奥美拉唑综合治疗的效果。方法选取2013年2月~2014年3月收治的40例消化性溃疡患者进行治疗,随机分组,实验组23例患者采用雷尼替丁和奥美拉唑的综合治疗,对照组17例患者选择雷尼替丁的治疗,对比疗效。结果实验组患者治疗有效率为91.30%,复发率为8.7%,对照组治疗有效率为76.47%,复发率为29.4%。两组患者的治疗效果和复发率差异有统计学意义(P<0.05)。结论消化性溃疡患者采用雷尼替丁和奥美拉唑的综合治疗,能够缓解恶心等胃肠道反应,复发率低,效果显著。%Objective To explore the effect on the treatment of peptic ulcer by ranitidine hydrochloride tablets combine omeprazole sodium for injection. Methods We divided the 40 patients into control group(17 cases)and experimental group(23 cases). Al the cases were chosen from February 2013 to March 2014. The patients in the experimental group adopted the ranitidine hydrochloride tablets combine omeprazole sodium for injection treatment and the control group adopted the ranitidine hydrochloride tablets treatment. We compared the difference beteen the two groups. Results The effective rate in the experimental group was 91.30%,and the recurrence rate was 8.7%. The effective rate in the control group was 76.47%,and the recurrence rate was 29.4%. It was in a high treatment efficiency and obvious difference between the two groups and the statistical y significant(P<0.05). Conclusion The patients with peptic ulcer adopt the ranitidine hydrochloride tablets combine omeprazole sodium for injection treatment wil obviously al eviate gastrointestinal reactions such as nausea. The recurrence rate was lower than others.

  8. Effect of Glucosamine Hydrochloride Capsules in the Treatment of Knee Osteoarthritis%盐酸氨基葡萄糖胶囊治疗膝骨关节炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    赵延斌; 林伍伍

    2011-01-01

    Objective; To observe the effect and adverse drug reactions of glucosamine hydrochloride capsules and meloxicom capsules in the treatment of knee osteoarthritis. Method; 103 patients with knee osteoarthritis were randomly assigned to receive oral glucosamine hydrochloride capsules ( observation group, n = 51) or meloxicom capsules (control group, n = 52 ) treatment for 6 weeks. Effect of the two groups were observed. Result: After 6 weeks treatment,the clinical symptoms of the patients all improved. The total effective rate of the observation group and control group was 47. 06% and 42. 31 % , respectively (P > 0. 05) and incidence rate of the adverse drug reactions was 3. 92% and 17. 31 % , respectively (P < 0. 01 ). Conclusion: Glucosamine hydrochloride capsules and meloxicom capsules are both the effective drugs for knee osteoarthritis treatment, and the incidence rate of adverse drug reactions of glucosamine hydrochloride capsules is lower than that of meloxicom capsules which is worthy of clinical application.%目的:观察比较盐酸氨基葡萄糖胶囊和美洛昔康胶囊治疗膝骨关节炎的临床疗效及不良反应.方法:103例膝骨关节炎患者随机分为观察组(n=51)和对照组(n=52),分别给予盐酸氨基葡萄糖胶囊和美罗昔康胶囊治疗6周,比较两组临床疗效.结果:两组患者临床症状均改善,总有效率分别为47.06%、42.31% (P>0.05),不良反应发生率分别为3.92%、17.31% (P <0.01).结论:盐酸氨基葡萄糖胶囊和美洛昔康胶囊均为治疗骨性关节炎的有效药物,盐酸氨基葡萄糖胶囊的不良反应更少,值得临床推广应用.

  9. 长托宁对急性有机磷农药中毒患者的疗效分析%Clinical analysis of Penehyclidine Hydrochloride treatment for acute organophosphate pesticide poisoning

    Institute of Scientific and Technical Information of China (English)

    罗来发

    2012-01-01

    Objective To observe the clinical effect on acute organophosphate pesticide poisoning treated by Penehyclidine Hydrochloride. Methods 76 cases with acucte organophosphate peticide poisoning were randomly divided into Penehyclidine Hydrochloride group and Atropine group, with 38 cases in each group. The two groups were given Penehyclidine Hydrochloride and Atropine at the base of conventional treatment, the efficacy was compared. Results The total effective rate of Penehyclidine Hydrochloride group was 97.4%, significantly higher than 78.9% of Atropine group (P < 0.05). The disappear time of poisoning symptoms and cholinesterase energy recovery in Penehyclidine Hydrochloride group was shorter than the Atropine group (P < 0.05). The drug dose and the average number of drugs were significantly different between the two groups (P < 0.05). The incidence rate of adverse reaction of Penehyclidine Hydrochloride group was 7.9%, significantly lower than Atropine group (26.3%) (P < 0.05). Conclusion The clinical effect on acute organophosphate pesticide poisoning treated by Penehyclidine Hydrochloride is satisfactory, recovery faster and less adverse reactions, which is worthy of clinical application.%目的 观察长托宁治疗急性有机磷农药中毒的临床疗效.方法 将76例急性有机磷中毒患者随机分为长托宁组和阿托品组,各38例,两组在常规治疗的基础上分别给予长托宁和阿托品肌注联合氯解磷定治疗,比较两组的临床疗效.结果 长托宁组和阿托品组的有效率分别为97.4%和78.9%,两组比较差异有统计学意义(P < 0.05);长托宁组的中毒症状消失时间和胆碱酯酶活力恢复时间均明显短于阿托品组,住院时间也明显缩短(P < 0.05).长托宁组的用量和给药次数均明显少于阿托品组(P < 0.05).治疗过程中长托宁组的不良反应发生率为7.9%,显著低于阿托品组的26.3%(P < 0.05).结论 长托宁用于急性有机磷中毒的抢救疗效显

  10. A Post Hoc Analysis of D-Threo-Methylphenidate Hydrochloride (Focalin) Versus D,l-Threo-Methylphenidate Hydrochloride (Ritalin)

    Science.gov (United States)

    Weiss, Margaret; Wasdell, Michael; Patin, John

    2004-01-01

    Objective: To evaluate clinical measures of the benefit/risk ratio in a post hoc analysis of a clinical trial of d-threo-methylphenidate hydrochloride (d-MPH) and d,l-threo-methylphenidate hydrochloride (d,l-MPH). Method: Data from a phase III clinical trial was used to compare equimolar doses of d-MPH and d,l-MPH treatment for…

  11. Formulation and In Vitro Evaluation of Bilayer Tablets of Nebivolol Hydrochloride and Nateglinide for the Treatment of Diabetes and Hypertension

    Directory of Open Access Journals (Sweden)

    Harika Ryakala

    2015-01-01

    Full Text Available Diabetes mellitus (DM and hypertension are two common diseases that often coexist. The most common cause of death in the diabetic patient is heart disease. In the present investigation we combine Nebivolol and Nateglinide for better patient compliance. IR layer was formulated using various superdisintegrants like Crospovidone, Croscarmellose sodium, and sodium starch glycolate and SR layer was formulated using polymers and gums like HPMC E15, ethyl cellulose, Gaur gum, and Xanthan gum. The disintegration and dissolution study of both layers showed that inclusion of surfactant (sodium lauryl sulphate to the tablet formulation (IR and dissolution medium (SR enhanced the release of drugs from both layers. Kinetic studies of optimized IR layer (NBL8 and SR layer (N9 showed good linearity with regression coefficient of 0.9714 (Higuchi model and 0.9931 (zero order kinetics, respectively. The above results reveal that the optimized IR layer of Nebivolol (NBL8 and SR layer of Nateglinide (N9 might be suitable for the treatment of diabetes and hypertension by sequential release of the two drugs in a bilayer tablet. IR-immediate release, SR-sustain release, NBL8-Nebivolol 8, N9-Nateglinide 9.

  12. Non-pigmented fixed drug eruption induced by eprazinone hydrochloride.

    Science.gov (United States)

    Tanabe, Kenichi; Tsuboi, Hiromi; Maejima, Hideki; Arai, Satoru; Katsuoka, Kensei

    2005-12-01

    A 68-year-old woman developed an upper respiratory tract infection in November 2002 and was treated with eprazinone hydrochloride, serrapeptase, carbocysteine and clarithromycin. Three days after the start of treatment, the patient noted erythema on her axilla, buttock and inguinal regions. The erythema subsided in 7 days although slight pigmentation remained. However, 7 days later the pigmentation completely disappeared. Oral eprazinone hydrochloride was given as a challenge, and 1 day later the erythema re-appeared in the same areas as on initial presentation (axilla, buttock, and inguinal regions). A fixed erythema without lasting pigmentation is attributed to eprazinone hydrochloride. Therefore, the patient was diagnosed as having a nonpigmented fixed drug eruption associated with eprazinone hydrochloride.

  13. 盐酸多奈哌齐在老年痴呆治疗中的应用研究%The Applied Research of Donepezil Hydrochloride in Treatment of Alzheimer

    Institute of Scientific and Technical Information of China (English)

    谢成玲

    2015-01-01

    目的:探究老年痴呆患者采用盐酸多奈哌齐治疗的方法和效果。方法选取2013年1月~2014年4月收治的86例老年痴呆患者进行治疗,随机分组,实验组49例患者采用盐酸多奈哌齐的治疗,对照组37例患者采取基础治疗,观察患者的治疗效果。结果实验组治疗有效率为85.71%,对照组治疗有效率为59.46%。两组患者的治疗效果差异显著,有统计学意义(P<0.05)。结论老年痴呆患者采用盐酸多奈哌齐的治疗,不良反应少,安全性高,缓解患者的身体症状。%Objective The treatment and efficiency of donepezil hydrochloride in Alzheimer are to be investigated. Methods Choose 86 patients with Alzheimer who are treated in hospital from January 2013 to April 2014 and separate them into control group and study group at random. 49 patients in study group are given donepezil hydrochloride treatment and 37 patients in control group are given elementary treatment. And then observe the treatment efficiency of two groups. Results The treatment efficiency in study group is up to 85.71%and treatment efficiency in control group is up to 59.46%,there is a treatment differential between the two groups,such a differential has statistic value(P<0.05).Conclusion Donepezil hydrochloride treatment is quite effective and safe to cure Alzheimer and relieve patients’ symptoms with less side-effect,which is worthy to be promoted and applied.

  14. The Applied Research on Ambroxol Hydrochloride in the Treatment of Bronchitis%盐酸氨溴索在支气管炎治疗中的应用研究

    Institute of Scientific and Technical Information of China (English)

    邢君

    2015-01-01

    Objective The treatment method and treatment effect of Ambroxol Hydrochloride in the treatment of Bronchitis is to be analyzed. Methods Choose 86 patients with bronchitis who are treated in hospital from April 2013 to July 2014 and separate them into study group and control group at random, 48 patients in study group are given Ambroxol Hydrochloride treatment, while 38 patients in control group are given bishuping medicine treatment, and then observe patients’ recovery state after treatment. Results The efficiency rate in study group is up to 93.75%, and in control group it is 81.58%;there is a great differential between two groups, which has the statistic value(P<0.05). Conclusion To cure patients with bronchitis, Ambroxol Hydrochloride treatment is quite effective to relieve patients’ symptoms and al eviate the pain.%目的:探究支气管炎患者采用盐酸氨溴索治疗的方法和效果。方法选取2013年4月~2014年7月收治的86例气管炎患者进行治疗,随机分组,实验组48例患者选择盐酸氨溴索的治疗,对照组38例患者选择必漱平的治疗,观察患者治疗后的身体情况。结果实验组治疗有效率为93.75%,对照组治疗有效率为81.58%。两组患者的治疗效果差异显著,有统计学意义(P<0.05)。结论支气管炎患者采用盐酸氨溴索的治疗,可明显缓解身体症状,减轻患者的痛苦,疗效显著。

  15. A Randomized Controlled Trial of Glucosamine Hydrochloride in the Treatment of Knee Osteoarthritis%盐酸氨基葡萄糖治疗膝骨关节炎的随机对照研究

    Institute of Scientific and Technical Information of China (English)

    苏江; 张晶; 吴侗; 周彬

    2012-01-01

    目的 评价盐酸氨基葡萄糖治疗膝骨关节炎的疗效.方法 将2012年1月-5月收治的150例膝骨关节炎患者随机分为A、B、C组.A组给予盐酸氨基葡萄糖治疗,B组给予碳酸钙D3片治疗,C组给予盐酸氨基葡萄糖联合碳酸钙D3片治疗,疗程8周.3组患者膝关节疼痛发作时服用塞来昔布并记录用量.比较试验前后3组患者骨关节炎指数评分(WOMAC)以及第1、8周塞来昔布用量变化情况.结果 3组患者WOMAC总分、疼痛程度评分、关节僵硬程度评分、日常活动困难程度评分改善值比较,差异均无统计学意义.经过8周治疗,塞来昔布每周用量减少值A、B、C组分别为(0.41±0.17)、(0.16±0.22)、(0.46±0.19)g,A、C组高于B组(P<0.01),A、C组每周用量减少值差异无统计学意义(P>0.05).结论 短期使用盐酸氨基葡萄糖治疗膝骨关节炎,在关节疼痛、僵硬及功能改善方面并不优于碳酸钙D3片,但可通过减少非甾体抗炎药物用量,使患者获益.%Objective To investigate the efficacy of glucosamine hydrochloride in the treatment of knee osteoarthritis. Methods A total of 150 out-patients with knee osteoarthritis treated in our hospital between January and May 2012 were randomly divided into group A, B and C. Patients in group A were treated with glucosamine hydrochloride for 8 weeks; Patients in group B were given calcium carbonate and vitamin D3 Tablets (Caltrate D) treatment for 8 weeks; and patients in group C were given glucosamine hydrochloride and Caltrate D treatment for 8 weeks. Patients in each group took celecoxib for pain killing, and the amount of celecoxib was recorded. We compared changes of WOMAC Osteoarthritis Index scores and weekly consumption of celecoxib among three groups after eight weeks of treatment. Results Improvement in WOMAC total score, pain intensity scores, joint stiffness scores, and scores of difficulty in daily activities among the three groups were not significantly

  16. 倍他司汀联合盐酸氟桂利嗪治疗耳鸣的疗效研究%Analysis of Clinical Effect of Betahistine Combined with Flunarizine Hy-drochloride in Treatment of Tinnitus

    Institute of Scientific and Technical Information of China (English)

    魏金龙; 赵志明; 杨艳; 王苏亮

    2015-01-01

    目的:对倍他司汀联合盐酸氟桂利嗪治疗耳鸣的疗效进行分析探讨。方法选取该院于2010年9月-2014年9月收治的102例耳鸣患者,将其随机分为对照组50例和观察组52例,其中对照组给予盐酸氟桂利嗪治疗,观察组患者给予倍他司汀联合盐酸氟桂利嗪治疗。治疗后评估两组的临床疗效、听力指标比较和不良反应。结果治疗后,观察组总有效率为96.2%,明显高于对照组总有效率的54.0%,两组差异有统计学意义(P0.05)。结论倍他司汀联合盐酸氟桂利嗪治疗耳鸣的疗效显著,并且无严重不良反应伴发,值得临床推广使用。%Objective To investigate the application of betahistine combined with flunarizine hydrochloride in treating tinnitus. Methods Selecting 102 in-patients with tinnitus treated in our hospital from September, 2010 to September, 2014. Randomly di-viding into control group with 50 treated by flunarizine hydrochloride and observation group with 52 treated by betahistine com-bined with flunarizine hydrochloride. The therapeutic effectiveness of the two groups was compared. Results The total efficiency of the observation group is 96.2%, which is higher than 54.0%of the control group(P0.05). Conclusion With advantages of good clinical effect and safety inthe treatment of tinni-tus,betahistine combined with flunarizine hydrochloride is worthy of clinic application.

  17. 评价盐酸多奈哌齐治疗老年痴呆患者的临床疗效%Clinical Efficacy of Donepezil Hydrochloride in the Treatment of Elderly Patients With Dementia

    Institute of Scientific and Technical Information of China (English)

    秦栎媛

    2016-01-01

    目的:评价盐酸多奈哌齐治疗老年痴呆的临床效果。方法我院收治老年痴呆患者共80例作为调查对象。对照组40例患者接受常规治疗;观察组40例患者除了常规治疗外,联合盐酸多奈哌齐进行治疗,分析比较两组患者的临床治疗效果。结果治疗前,两组患者的MMSE评分及ADL评分比较差异无统计学意义(P>0.05);而治疗12周比较,观察组患者的MMSE评分及ADL评分改善优于对照组,组间差异有统计学意义(P<0.05)。结论盐酸多奈哌齐治疗老年痴呆效果优,安全性高。%Objective To evaluate the clinical effect of donepezil hydrochloride in the treatment of senile dementia.Methods Atotal of 80 cases of senile dementia were treated in our hospital. The control group(40 cases)were treated with conventional therapy,observation group of 40 patients in addition to conventional treatment,combined with donepezil hydrochloride treatment and between the two groups of patients with clinical therapeutic effect were compared.Results Before treatment,two groups of patients with the scores of MMSE and ADL score had no significant difference(P>0.05),and 12 weeks of treatment,the observation group of patients with the scores of MMSE and ADL score were better than the control group,the difference exist significant difference(P<0.05).Conclusion Donepezil hydrochloride in the treatment of senile dementia with obvious effect,high safety.

  18. Curative effect observation of ambroxol hydrochloride on treatment of secretory otitis media%盐酸氨溴索治疗分泌性中耳炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    高文燕

    2015-01-01

    Objective To observe the curative effect of ambroxol hydrochloride on treatment of secretory otitis media. Methods 58 patients with 3 months pathogenesis of secretory otitis media and 26 cases in control group were treated by auripuncture,and then using antibiotics,hormone and parallelling tympanic membrane massage treatment. The treatment group added ambroxol. The curative effects of two groups were comparatively observed and statistical processing was adopt-ed. Results Two weeks after treatment,the curative effect of treatment group was obviously higher than control group( P<0. 05 ). Conclusion The curative effect of ambroxol hydrochloride on treatment of secretory otitis media was safe and effec-tive.%目的:观察盐酸氨溴索治疗分泌性中耳炎的疗效。方法将病程3个月的分泌性中耳炎患者58例、对照组26例耳鼓膜穿刺抽液后,抗生素、激素并行鼓膜按摩治疗,其中治疗组加用氨溴索治疗,对比观察两组的治疗效果并作统计处理。结果治疗2周后治疗组的有效明显高于对照组( P<0.05)。结论应用盐酸氨溴索治疗分泌性中耳炎安全有效。

  19. The Clinical Analysis of Glucosamine Hydrochloride in Treatment of Patients With Osteoarthritis%盐酸氨基葡萄糖治疗骨关节炎的临床分析

    Institute of Scientific and Technical Information of China (English)

    王建彬

    2015-01-01

    Objective The clinical analysis of glucosamine hydrochloride in treatment of patients with osteoarthritis is to be investigated. Methods Choose 38 patients with osteoarthritis who are treated in hospital from June 2013 to November 2014 and separate them into study group and control group according to their hospitalization sequence. Patients in study group are given a glucosamine hydrochloride treatment, while patients in control group are given Diclofenac treatment;and then observe and compare the treatment ef icacy of these two groups. Results The treatment ef icacy in study group is much higher than control group, there is a treatment dif erential between the two groups, and such a dif erential has statistic value(P<0.05). and in addition, the ISOA index, VAS score and side-ef ect incidence of patients in study group are quite lower than those in control group,there is a treatment dif erential between the two groups,and such a dif erential has statistic value(P<0.05). Conclusions Glucosamine hydrochloride is quite ef ective in treatment of patients with osteoarthritis and it is conducive to improving treatment ef icacy and reducing side-ef ect incidence;thus, glucosamine hydrochloride is quite worthwhile to be promoted and applied clinical y in treatment of osteoarthritis.%目的:探讨盐酸氨基葡萄糖治疗骨关节炎的临床分析。方法选取2013年6月~2014年11月我院接诊的38例骨关节炎患者,按照入院的先后顺序分为实验组和对照组,实验组采用盐酸氨基葡萄糖,对照组采用双氯芬酸钠,观察两组患者的治疗效果。结果实验组患者的治疗总有效率明显高于对照组,差异显著,有统计学意义(P<0.05);实验组患者的严重性指数(ISOA)、疼痛视觉模拟评分(VAS)、不良反应发生率明显低于对照组,差异显著,有统计学意义(P<0.05)。结论盐酸氨基葡萄糖治疗骨关节炎的效果显著,有效提高治疗总有效率

  20. 盐酸多奈哌齐在老年痴呆治疗中的应用研究%Application research of donepezil hydrochloride in the treatment of Alzheimer’s disease

    Institute of Scientific and Technical Information of China (English)

    李明

    2015-01-01

    Objective To investigate treatment method and effect by donepezil hydrochloride in the treatment of Alzheimer’s disease.Methods A total of 67 patients with Alzheimer’s disease were randomly divided into experimental group with 43 cases and control group with 24 cases. The experimental group received donepezil hydrochloride for treatment, and the control group received conventional treatment. Their curative effects were observed.Results The experimental group had total effective rate as 93.0%, and the control group had it as 75.0%. Their difference had statistical significance (P<0.05).Conclusion Application of donepezil hydrochloride in the treatment of Alzheimer’s disease patients can accelerate improvements of cognitive ability and ability of daily life in patients. This method provides remarkable effect, along with few adverse reactions. It is worthy wide promotion.%目的:探究老年痴呆患者采用盐酸多奈哌齐治疗的方法和效果。方法67例老年痴呆患者,随机分为实验组43例和对照组24例,实验组患者给予盐酸多奈哌齐治疗,对照组患者给予常规治疗,观察患者的治疗效果。结果实验组治疗总有效率为93.0%,对照组治疗总有效率为75.0%,差异有统计学意义(P<0.05)。结论老年痴呆患者采用盐酸多奈哌齐治疗,可促使患者认知能力和日常生活能力的提高,效果显著,不良反应少,可广泛推荐。

  1. Treatment of lantus and metformin hydrochloride and glibenclamide tablets on primary type 2 diabetesy%来得时联合拜唐平治疗初发Ⅱ型糖尿病疗效观察

    Institute of Scientific and Technical Information of China (English)

    曲建梅; 王晓梅

    2013-01-01

    目的 观察来得时联合拜唐平治疗初发Ⅱ型糖尿病的临床疗效,并作安全性评价.方法 将符合初发Ⅱ型糖尿病纳入标准病例90例,按入院顺序随机分为治疗组45例与对照组45例,对照组予以诺和灵30R治疗,治疗组给予来得时联合拜唐平治疗,比较两组的疗效,以及两组治疗前后各项实验室指标的变化情况.结果 治疗组总有效率明显优于对照组(P<0.05),且治疗组在降低空服血糖、餐后2小时血糖及糖化血红蛋白水平方面均明显优于对照组(P<0.05或P<0.01).治疗组低血糖发生率明显低于对照组,差异有统计学意义(P<0.05).结论 来得时联合拜唐平治疗初发Ⅱ型糖尿病疗效确切,安全有效,低血糖发生率低,值得临床推广应用.%Objective To observe the efficacy of lantus and metformin hydrochloride and glibenclamide tablets on primary type 2 diabetes.Methods 90 cases were randomly divided into treatment group (45 cases) and the control group (45 cases).The treatment group was treated with lantus and metformin hydrochloride and glibenclamide tablets and the control group with Novolin.The laboratory parameters before and after treatment were observed.Results The treatment group in the lower flight blood glucose 2-hour postprandial blood glucose and glycosylated hemoglobin levels significantly better than the control group (P<0.05 or P<0.01).The incidence of hypoglycemia in the Treatment group was significantly lower than that of the control group.The difference was statistically significant (P<0.05).Conclusion It is safe and effective to treat primary type 2 diabetes with lantus and metformin hydrochloride and glibenclamide tablets.

  2. 盐酸氟桂利嗪预防性治疗偏头痛性眩晕临床疗效分析%Effect of preventive treatment of Flunarizine hydrochloride for migrainous vertigo

    Institute of Scientific and Technical Information of China (English)

    米彦芳; 闫保星; 单子丽

    2012-01-01

    Objective To observe the effect of Flunarizine hydrochloride in treating migrainous vertigo ( MV). Methods Totally 46 patients with MV were divied into treatment group and control group. Flunarizine hydrochloride capsules (10mg, QN) + Betahistine mesilate tablets (6mg, TID) were used in treatment group, and Betahistine mesilate tablets (6mg, TID) in control group. The number of episodes and severity of attack about MV were observed within 3 months of treatment. Results The number of episodes and severity of attack about MV in treatment group was lighter than that of the control group with statistically significant difference ( P > 0. 05). Conclusions The effect of preventive treatment of Flunarizine hydrochloride for MV is clear.%目的 观察探讨盐酸氟桂利嗪预防性治疗偏头痛性眩晕的疗效.方法 选取临床确诊的偏头痛性眩晕患者46例,将其分为观察组及对照组.观察组给予盐酸氟桂利嗪胶囊( 10mg,QN)+甲磺酸培他司汀片(6mg,TID)联合口服;对照组给予甲磺酸培他司汀片(6mg,tid)单独口服.观察开始治疗3个月内头痛和眩晕发作的严重程度和发作的次数.结果 治疗后3个月内,观察组较对照组在头痛发和眩晕发作的程度和次数上均有有明显减轻,差异具有统计学意义(P>0.05).结论 盐酸氟桂利嗪预防性治疗偏头痛性眩晕具有明确疗效.

  3. A randomized, double-blind, parallel-group, multicenter, placebo-controlled study of the safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for symptom relief as an adjunctive therapy to antibiotic treatment of acute respiratory infections.

    Science.gov (United States)

    LaForce, Craig; Gentile, Deborah A; Skoner, David P

    2008-07-01

    This study assessed the efficacy and safety of guaifenesin 600 mg and pseudoephedrine hydrochloride 60 mg extended-release bilayer tablets in providing relief of acute respiratory symptoms when used as an adjunct to antibiotics in patients with an acute respiratory infection (ARI). Adult patients experiencing symptoms of ARI and meeting the physician's usual diagnostic criteria for oral antibiotic treatment were prescribed an antibiotic and randomized to adjunctive guaifenesin/pseudoephedrine hydrochloride or matching placebo twice daily for 7 days. Patients completed symptom diaries and treatment assessments twice daily and attended office visits on Days 4 and 8. The safety/intent-to-treat (ITT) population analysis included 601 patients (guaifenesin/pseudoephedrine, n = 303; placebo, n = 298). Mean symptom scores were lower with guaifenesin/pseudoephedrine from Day 3 for every symptom assessed, with statistically significant improvements in total symptom score from Day 3 (P = 0.026). The greatest effects of treatment with guaifenesin/pseudoephedrine were observed for nasal congestion and sinus headache. Time to overall relief was shorter with guaifenesin/pseudoephedrine (P = 0.038). Significantly more patients reported "the medication was helping during the day" on Day 2 with guaifenesin/pseudoephedrine (P = 0.002). Patient assessments of symptom relief showed a significant preference for guaifenesin/pseudoephedrine versus placebo (P = 0.021). Treatment with guaifenesin/pseudoephedrine was well tolerated. Insomnia (2.6%), nausea (2.3%), and headache (1.3%) were the most common treatment-related adverse effects. As adjunctive therapy for symptom relief for patients taking antibiotics for ARIs, guaifenesin/pseudoephedrine shortened time to relief and improved bothersome respiratory symptoms better than placebo, with greatest effects seen for nasal congestion and sinus headache.

  4. 盐酸美沙酮片维持治疗重度或难治性癌性疼痛效果分析%Effect of Methadone Hydrochloride Tablets in the Treatment of Severe or Refractory Cancer Pain

    Institute of Scientific and Technical Information of China (English)

    孙建明

    2015-01-01

    Objective To explore the analgesic effect and safety of methadone hydrochloride tablets in the treatment of severe or refractory cancer pain.Methods 68 cases of advanced cancer patients with severe or refractory cancer pain,were al used morphine tablets titration,when the pain intensity was less than or equal to 3 points used methadone hydrochloride tablets maintenance treatment.ResultsThere was a significant difference in the analgesic effect of 2,4,6 and 8 during the treatment of methadone hydrochloride tablets(P< 0.05). The adverse reaction rate in the patients of dizziness,nausea vomiting, constipation, cold sweat and lethargy was7.4%、2.9%、19.1%、1.5%、2.9%.Conclusion Analgesic effect of severe or refractory cancer pain treated by methadone maintenance treatment is good, safe and high.%目的:探究盐酸美沙酮片维持治疗重度或难治性癌性疼痛的效果。方法选取存在重度或难治性癌性疼痛的晚期癌症患者68例,均采用吗啡片滴定,待疼痛强度≤3分后转换为盐酸美沙酮片维持治疗。结果盐酸美沙酮片维持治疗期间患者第2、4、6和8周末镇痛效果比较,差异存在统计学意义(P<0.05);患者头晕、恶心呕吐、便秘、冷汗以及嗜睡等不良反应发生率分别为7.4%、2.9%、19.1%、1.5%、2.9%。结论重度或难治性癌性疼痛采用盐酸美沙酮维持治疗镇痛效果良好,安全性高。

  5. Analysis of the effect of ambroxol hydrochloride in the treatment of acute exacerbation of chronic bronchitis%盐酸氨溴索治疗慢性支气管炎急性发作的疗效分析

    Institute of Scientific and Technical Information of China (English)

    丁宁

    2014-01-01

    目的:观察盐酸氨溴索对慢性支气管炎急性发作的临床疗效。方法:选取2012年11月-2014年3月慢性支气管炎急性发作患者60例,随机分为对照组30例和试验组30例。对照组给予吸氧、抗感染、解痉平喘等常规治疗;试验组在常规治疗基础上加用盐酸氨溴索静脉滴注,每次30 mg,每日2次,5 d为1个疗程,共2个疗程,治疗结束后比较两组疗效。结果:试验组的总有效率为96.75%,对照组为76.7%,组间差异有统计学意义(P<0.05)。结论:盐酸氨溴索治疗慢性支气管炎急性发作有较好的临床疗效。%Objective:To observe the clinical effect of ambroxol hydrochloride in the treatment of acute exacerbation of chronic bronchitis. Methods: Sixty cases with acute exacerbation of chronic bronchitis were selected from Nov. 2012 to March 2014 and divided into a control group with 30 patients and an experiment group with 30 patients at the random. The control group was treated with oxygen inhalation, anti-infection, antispasmodic and the conventional therapy. The experiment group was added with ambroxol hydrochloride injection of 30 mg every time, twice a day, 5 days a course for 2 courses based on the conventional therapy. The treatment effects of two groups were compared after the treatment. Results:The total efifcacy was 96.7% in the experiment group, and 76.7% in the control group. The difference of the two groups had the statistical signiifcance (P<0.05). Conclusion:Ambroxol hydrochloride has a good clinical effect in the treatment of acute exacerbation of chronic bronchitis.

  6. The Effect of Donepezil Hydrochloride in the Treatment of Senile Dementia%盐酸多奈哌齐治疗老年性痴呆疗效研究

    Institute of Scientific and Technical Information of China (English)

    金梅香

    2015-01-01

    Objective To investigate the effect of donepezil hydrochloride in the treatment of senile dementia. Methods 178 AD patients were collected which were treated in our department from June 2012 to June 2014, and were randomly divided into obser-vation group and control group with each of 89 cases. The observation group were given donepezil treatment, The control group was given the Laci Staw treatment, two groups of curative effect were compared. Results The total effective rate of observation group was 93.2%, the control group was 74.2%, The difference was statistically significant (P0.05). Conclusion Donepezil hydrochloride in the treatment of AD can significantly improve the cognitive function of patients, the effect is significant and worth to apply.%目的:探讨盐酸多奈哌齐治疗老年性痴呆的效果。方法整群选取该院2012年6月-2014年6月收治的AD患者178例,随机分为2组各89例,观察组给予盐酸多奈哌齐治疗,对照组给予吡拉西坦治疗,比较两组疗效。结果观察组总有效率为93.2%,对照组总有效率为74.2%,两组比较差异有统计学意义(P0.05)。结论盐酸多奈哌齐治疗AD可明显改善患者认知功能,效果显著,值得应用。

  7. 21 CFR 524.1484d - Neomycin sulfate, hydrocortisone acetate, tetracaine hydrochloride ear ointment.

    Science.gov (United States)

    2010-04-01

    ..., tetracaine hydrochloride ear ointment. 524.1484d Section 524.1484d Food and Drugs FOOD AND DRUG..., tetracaine hydrochloride ear ointment. (a) Specifications. The product contains 5 milligrams of neomycin... a lesser degree, chronic otitis externa in dogs and cats. In treatment of ear canker and...

  8. Effects of metomindate hydrochloride and tricaine methanesulfonate on the short term cortisol response in channel catfish

    Science.gov (United States)

    The effects of metomidate hydrochloride and tricaine methanesulfonate (MS-222) on cortisol stress response of channel catfish, Ictalurus punctatus, were examined during 10 minutes of sedation. Channel catfish were assigned to three treatments: 1. Metomidate hydrochloride (12.5 mg/L), 2. MS-222 (100...

  9. Therapeutic effects of minocycline hydrochloride ointment in treatment of early pericoronitis%盐酸米诺环素治疗早期智齿冠周炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    叶虎; 翟沁凯; 张建凤

    2014-01-01

    目的:探讨盐酸米诺环素局部治疗早期智齿冠周炎的临床疗效。方法选择急性智齿冠周炎患者49例,随机分成试验组27例,对照组22例。试验组经2%过氧化氢液和生理盐水交替冲洗冠周后,将盐酸米诺环素软膏注入智齿冠周及龈袋内,3d后复诊;对照组经冠周冲洗后于龈袋内置碘甘油,连续冲洗上药3d。记录评价疗效。结果智齿冠周炎病例中垂直(颊向)位所占比例明显高于近中(水平)位。试验组治疗有效率高于对照组,差异有统计学意义(P<0.05)。结论盐酸米诺环素是治疗早期智齿冠周炎的理想药物。%Objective To investigate the clinical effects of minocycline hydrochloride ointmemnt in the local treatment of early peri-coronitis.Methods Forty-nine cases of early pericoronitis of wisdom teeth were randomly divided into two groups.The experimental group (27 cases)was treated with minocycline hydrochloride ointment after routine pocket rinsing by 2%hydrogen dioxide solution and normal sa-line.The control group (22 cases)was treated with iodine glycerin after the same rinsing for 3 days.Therapeutic effects between the two groups were assessed 3 days later after treatment.Results The percentage of verti-buccal cases was higher than that of the mesio-horizontal. There was a significant difference in the effective rate between the experimental group and control group.Conclusion The minocycline hydro-chloride ointment is appropriate in the treatment of early pericoronitis.

  10. 盐酸米诺环素软膏辅助治疗智齿冠周炎的临床观察%Clinical Observation of Minocycline Hydrochloride Ointment for Adjuvant Treatment of Pericoronitis

    Institute of Scientific and Technical Information of China (English)

    覃文献

    2016-01-01

    目的::探讨盐酸米诺环素软膏辅助治疗智齿冠周炎的临床效果。方法:选择某院2014年5月~2015年5月期间收治的108例智齿冠周炎患者的临床资料进行回顾性分析,按治疗方法不同分为治疗组(n =55)和对照组(n =53)。对照组患者采用碘甘油进行治疗,而治疗组患者则在对照组的基础上给予盐酸米诺环素软膏辅助治疗。观察两组患者的疼痛缓解时间及治疗时间差异,比较两种治疗方法下的临床总有效率。结果:治疗组的疼痛缓解时间为(2.28±0.97)d,总治疗时间为(8.51±3.24)d,均明显短于对照组的(5.73±1.84)d、(23.62±7.12)d;并且,治疗组显效41例,有效12例,无效2例,冠周炎治疗有效率为96.36%(53/55),明显高于对照组的77.36%(41/53),两组间差异比较均具有统计学意义(P <0.05)。结论:盐酸米诺环素软膏应用于智齿冠周炎的辅助治疗中,可显著缩短治疗时间,其疗效明显优于单纯碘甘油治疗,值得在临床上推广使用。%Objective:To explore the clinical results of minocycline hydrochloride ointment for the treat-ment of pericoronitis.Methods:108 patients with pericoronitis were selected from 2014 May to 2015 May in a hospital for retrospectively analyzed and were divided into the treatment group (n = 55 )and the control group (n =53)according to different treatment methods.The control group were treated with iodine glycerin and the treatment group were treated with minocycline hydrochloride ointment on the basis of the control group.The difference of the pain relief time and treatment time between the two groups were observed and the clinical total effective rate of the two treatment methods were compared.Results:The pain relief time of the treatment group was (2.28±0.97)d and the total treatment time was (8.5 1±3.24)d,significantly shorter than that (5.73±1.84)d,(23.62±7.12)d of the control group;And the treatment group were markedly effec-tive for 41 cases

  11. 阿奇霉素联合盐酸氨溴索治疗小儿哮喘疗效分析%Analysis of Curative Effect of Azithromycin Combined With Ambroxol Hydrochloride in the Treatment of Children With Asthma

    Institute of Scientific and Technical Information of China (English)

    汪秀丽

    2015-01-01

    Objective To investigate the ef icacy of ambroxol hydrochloride combine with azithromycin in treatment of asthma in children. Methods 50 cases of pediatric asthma from May 2014 to March 2015 in our hospital were selected for research subject. The patients were randomly divided into combine groups and single drug group. The single drug group was received azithromycin drug while combination group was received ambroxol hydrochloride therapy. The therapeutic ef ects, symptom disappearance time and adverse reaction of two groups were observed. Results The total ef ective rate of combined group was significantly higher than that of single drug group(P0.05). Conclusion Ambroxol hydrochloride combined with azithromycin in treatment of pediatric asthma has exact ef ect. The clinical symptoms of the patients are disappeared quickly. There are no serious side ef ects.%目的:观察临床应用阿奇霉素联合盐酸氨溴索治疗小儿哮喘的疗效。方法将我院2014年5月~2015年3月诊治的50例小儿哮喘患儿随机分为药物联合组和药物单用组,药物单用组给予阿奇霉素,药物联合组给予阿奇霉素联合盐酸氨溴索治疗,观察两组患儿的治疗效果、症状消失时间和不良反应发生情况。结果药物联合组患儿治疗总有效率高于药物单用组(P0.05)。结论盐酸氨溴索联合阿奇霉素治疗小儿哮喘的临床效果确切,患者临床症状消失快,不会带来严重副反应。

  12. 盐酸米诺环素联合甲硝唑治疗牙周病临床效果研究%To Explore the Clinical Effect of Minocycline Hydrochloride Combined With Metronidazole to Treatment of Periodontal Disease

    Institute of Scientific and Technical Information of China (English)

    张文

    2015-01-01

    Objective In order to further improve the hospital for treatment of periodontal disease, relieve the suffering of the patients, this article, they worshiped minocycline hydrochloride joint metronidazole for the treatment of periodontal disease clinical curative effect has carried on the simple research and discussion.Methods Our hospital from April 2013 to August 2014 admitted during the period of 56 patients with periodontal disease, according to the order of patients in hospital were separated into experimental group (n=28) and the control group (n=28), metronidazole, giving the control group patients give experimental minocycline hydrochloride in patients with combined therapy with metronidazole, therapeutic effect and quality of life in patients with both score and the incidence of adverse events were observed and statistics.Results The total effective rate of experimental group patients was higher than the control group patients,P<0.05,the difference had statistical significance. Conclusion Using minocycline hydrochloride combined therapy with metronidazole periodontal disease clinical effect is remarkable.%目的:为了进一步提高我院治疗牙周病的临床效果,减轻患者的痛苦,本文就盐酸米诺环素联合甲硝唑治疗牙周病的临床疗效进行了简单的研究和探讨。方法2013年4月~2014年8月期间,我院收治56例牙周病患者,按照患者入院的先后顺序分为实验组(n=28)和对照组(n=28),给予对照组患者甲硝唑治疗,给予实验组患者盐酸米诺环素联合甲硝唑治疗,对两者患者治疗效果以及生活质量评分和不良事件发生率进行观察和统计。结果实验组患者的总有效率高于对照组患者,P<0.05,差异具有统计学意义。结论采用盐酸米诺环素联合甲硝唑治疗牙周病临床效果显著。

  13. Clinical study of duloxetine hydrochloride combined with doxazosin for the treatment of pain disorder in chronic prostatitis/chronic pelvic pain syndrome: An observational study.

    Science.gov (United States)

    Zhang, Mingxin; Li, Hanzhong; Ji, Zhigang; Dong, Dexin; Yan, Su

    2017-03-01

    To explore the safety and efficacy of the selective 5-serotonin and norepinephrine reuptake inhibitor duloxetine hydrochloride and alpha-adrenergic receptor blocker (alpha-blocker) doxazosin mesylate-controlled tablets in the treatment of pain disorder in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).In all, 150 patients were enrolled and 126 patients completed the study (41 patients in the doxazosin group, 41 patients in the sertraline group, and 44 patients in the duloxetine group). This was an open randomized 6-month study. CP/CPPS patients who met the diagnostic criteria were randomized into 3 groups. The patients in the duloxetine group received doxazosin 4 mg + duloxetine 30 mg once a day, and the dosage of duloxetine was increased to 60 mg after a week. The patients in the doxazosin group received doxazosin 4 mg once a day. The patients in the sertraline group received doxazosin 4 mg + sertraline 50 mg once a day. National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score, the short-form McGill Pain questionnaire (SF-MPQ), and the hospital anxiety and depression scale (HAD) were applied for evaluations during follow-up of 1, 3, and 6 months after treatment.There were slight positive significant correlations between NIH-CPSI scores and HAD scores, moderate positive significant correlations between the quality of life (QOL) and SF-MPQ, and slight positive significant correlations between HAD and QOL. The effective rate in the doxazosin group was 4.88%, 19.51%, and 56.10% after 1, 3, and 6 months, respectively (P < 0.05). The SF-MPQ score in the doxazosin group decreased to 1.80 ± 1.29, 2.66 ± 1.57, and 3.24 ± 1.67 after 1, 3, and 6 months, respectively (P < 0.05). The HAD score in the doxazosin group decreased to 2.24 ± 2.17, 4 ± 2.11, and 4.90 ± 2.62 after 1, 3, and 6 months, respectively (P < 0.05). The effective rate in the sertraline group was 9.76%, 36.59%, and 63

  14. Clinical study of duloxetine hydrochloride combined with doxazosin for the treatment of pain disorder in chronic prostatitis/chronic pelvic pain syndrome

    Science.gov (United States)

    Zhang, Mingxin; Li, Hanzhong; Ji, Zhigang; Dong, Dexin; Yan, Su

    2017-01-01

    Abstract To explore the safety and efficacy of the selective 5-serotonin and norepinephrine reuptake inhibitor duloxetine hydrochloride and alpha-adrenergic receptor blocker (alpha-blocker) doxazosin mesylate-controlled tablets in the treatment of pain disorder in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). In all, 150 patients were enrolled and 126 patients completed the study (41 patients in the doxazosin group, 41 patients in the sertraline group, and 44 patients in the duloxetine group). This was an open randomized 6-month study. CP/CPPS patients who met the diagnostic criteria were randomized into 3 groups. The patients in the duloxetine group received doxazosin 4 mg + duloxetine 30 mg once a day, and the dosage of duloxetine was increased to 60 mg after a week. The patients in the doxazosin group received doxazosin 4 mg once a day. The patients in the sertraline group received doxazosin 4 mg + sertraline 50 mg once a day. National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score, the short-form McGill Pain questionnaire (SF-MPQ), and the hospital anxiety and depression scale (HAD) were applied for evaluations during follow-up of 1, 3, and 6 months after treatment.There were slight positive significant correlations between NIH-CPSI scores and HAD scores, moderate positive significant correlations between the quality of life (QOL) and SF-MPQ, and slight positive significant correlations between HAD and QOL. The effective rate in the doxazosin group was 4.88%, 19.51%, and 56.10% after 1, 3, and 6 months, respectively (P < 0.05). The SF-MPQ score in the doxazosin group decreased to 1.80 ± 1.29, 2.66 ± 1.57, and 3.24 ± 1.67 after 1, 3, and 6 months, respectively (P < 0.05). The HAD score in the doxazosin group decreased to 2.24 ± 2.17, 4 ± 2.11, and 4.90 ± 2.62 after 1, 3, and 6 months, respectively (P < 0.05). The effective rate in the sertraline group was 9.76%, 36

  15. Design and in vitro haemolytic evaluation of cryptolepine hydrochloride-loaded gelatine nanoparticles as a novel approach for the treatment of malaria.

    Science.gov (United States)

    Kuntworbe, Noble; Al-Kassas, Raida

    2012-06-01

    Cryptolepine hydrochloride-loaded gelatine nanoparticles were developed and characterised as a means of exploring formulation techniques to improve the pharmaceutic profile of the compound. Cryptolepine hydrochloride-loaded gelatine-type (A) nanoparticles were developed base on the double desolvation approach. After optimisation of formulation parameters including temperature, stirring rate, incubation time polymer and cross-linker (glutaraldehyde) concentrations, the rest of the study was conducted at two different formulation pH values (2.5 and 11.0) and by two different approaches to drug loading. Three cryoprotectants--sucrose, glucose and mannitol--were investigated for possible use for the preparation of freeze-dried samples. Nanoparticles with desired size mostly less than 350 nm and zeta potential above ±20 were obtained when formulation pH was between 2.5 and 5 and above 9. Entrapment efficiency was higher at pH 11.0 than pH 2.5 and for products formulated when drug was loaded during the second desolvation stage compared to when drug was loaded onto pre-formed nanoparticles. Further investigation of pH effect showed a new isoelectric point of 6.23-6.27 at which the zeta potential of nanoparticles was zero. Sucrose and glucose were effective in low concentrations as cryoprotectants. The best formulation produced an EC(50) value of 227.4 μM as a haemolytic agent compared to 51.61 μM by the free compound which is an indication of reduction in haemolytic side effect. There was sustained released of the compound from all formulation types over a period of 192 h. Stability data indicated that the nanosuspension and freeze-dried samples were stable at 4 and 25°C, respectively, over a 52-week period, but the former was less stable at room temperature. In conclusion, cryptolepine hydrochloride-loaded gelatine nanoparticles exhibited reduced haemolytic effect compared to the pure compound and can be developed further for parenteral delivery.

  16. Clinical effect of sevelamer hydrochloride combined with hemodialysis in the treatment of renal osteopathy%盐酸司维拉姆联合血液透析治疗肾性骨病的临床效果

    Institute of Scientific and Technical Information of China (English)

    许美娟; 邵洁莹

    2015-01-01

    Objective To investigate and analyze the clinical effect of sevelamer hydrochloride combined with hemodialysis in the treatment of renal osteopathy. Methods 90 cases of patients with renal osteodystrophy in our hospi-tal from June 2013 to June 2014 were selected and were randomly divided into control group A,control group B and observation group.The patients in control group A and control group B were respectively treated with sevelamer hy-drochloride and hemodialysis.The patients in observation group were treated with the combination of sevelamer hy-drochloride and hemodialysis.The clinical therapeutic effect,commonly used biochemical indicators before and after treatment and adverse reactions after treatment among three groups of patients was observed respectively. Results The levels of Ca2+,P3-,calcium-phosphorus product and PTH among three groups of patients didn't show obvious difference before treatment.The levels of Ca2+among three groups of patients were increased after treatment,and the level of Ca2+in observation group was significantly higher than that in control group A and B.The levels of P3-,calcium-phosphorus product and PTH were decreased among three groups of patients,and the levels of P3-,calcium-phosphorus product and PTH in observation group were significantly lower than that in control group A and B,with statistical difference(P<0.05). Total clinical efficiencies in control group A,B and observation group were separately 70.00 %,60.00 % and 93.33%. The efficiency in observation group was significantly higher than that in control group A and B,with statistical differ-ence(P<0.05).The incidences of adverse reactions among three groups were separately 53.33%,56.67% and 10.00%.The incidence of adverse reaction in observation group was significantly lower than that in control group A and control group B,with statistical difference (P<0.05). Conclusion The clinical effect of sevelamer hydrochloride combined with hemodialysis in the treatment of renal

  17. Efficacy and safety of domestic slomerizine hydrochloride in treatment of migraine%国产盐酸洛美利嗪治疗偏头痛的临床疗效及安全性

    Institute of Scientific and Technical Information of China (English)

    黄楚泉; 张圳锐; 蔡立泓; 郭正端

    2013-01-01

    Objective To study the efficacy and safety of lomerizine hydrochloride for treating migraine.Methods Fifty patients with migraine were randomly divided into lomerizine hydrochloride group (group A,25 cases) and control group (group B,25 cases),and the patients were treated with lomerizine hydrochloride or placebo orally respectively.The treatment were 12 weeks.The frequency of migraine attacks as the main assessment indicators,and attack duration,extent,accompanied by symptoms and headache composite score for secondary assessmentindicators,and recorded adverse reactions.Results ① The 4,8,12 and 16 weeks after treatment,the headache attack frequency,headache duration,headache extent,associated symptom and headache composite in group A were decreased significantly compared with group B (P all <0.01).②The total effective rates of group A and group B were 96.0% and 16.0% respectively (P < 0.01).No serious adverse reaction occured in both groups.Conclusions Lomerizine hydrochloride is effective and safe for preventive treatment of migraine and there is still a certain period of time effect after stop medication.%目的 评价国产盐酸洛美利嗪治疗偏头痛的临床疗效及安全性.方法 采取随机、双盲、安慰剂对照进行观察,将入选的50例患者随机分为盐酸洛美利嗪组(A组,25例,口服盐酸洛美利嗪片5 mg,2次/d)及对照组(B组,25例,口服安慰剂,2次/d),疗程均为12周.以头痛发作频率为主要评定指标,发作持续时间、程度、伴随症状及头痛综合评分为次要评定指标,并记录不良反应.结果 ①A组治疗第4、8、12、16周末时,头痛发作频率、头痛持续时间、头痛程度、伴随症状及头痛综合评分较B组显著降低(P<0.01);②A组总有效率为96.0%,显著优于B组的16.0% (P<0.01).两组治疗期间均无严重不良反应.结论 国产盐酸洛美利嗪预防性治疗偏头痛安全、有效,而且停药后仍有一定时间的疗效.

  18. Octenidine hydrochloride in hydatid disease.

    Science.gov (United States)

    Altindis, Mustafa; Arikan, Yuksel; Cetinkaya, Zafer; Polat, Coskun; Yilmaz, Sezgin; Akbulut, Gökhan; Dilek, Osman Nuri; Gokce, Ozcan

    2004-01-01

    Hydatid disease is still endemic in many devoloping countries and continues to be an important cause of morbidity. The objective of this study was to determine the in vitro scolicidal effects of octenidine hydrochloride in different concentrations using different exposure times. After hydatid cyst liquid was left to precipitate for 1 h to obtain cystic sand, various concentrations of octenidine (undiluted, 1% and 0.1% diluted) were added to concentrated hydatid cyst sediments for 5, 10, 15, 20, 25, 30, 45, and 60 min, and scolicidal effects of octenidine were compared with 20% saline and control group for the same times. It was found that undiluted octenidine had a strong scolicidal effect at 15 min compared to saline at 20%. One percent octenidine had a scolicidal effect at 30 min. However, 0.1% octenidine did not have enough scolicidal effect in 1 h. It was concluded that undiluted and 1% diluted octenidine might be used for scolicidal purpose in the treatment of hydatid disease.

  19. Effect of matrine hydrochloride on liver injury

    Institute of Scientific and Technical Information of China (English)

    CHEN Li-bo; XU Feng; MA Wen-hui

    2008-01-01

    Objective Searching the function that the Injection of the matrine hydrochloride prevents and cures acute chemical liver injury of mice、 immunity liver injury of mice and chronic liver injury of rats. Methods Acute hepatic injury models of mice induced by Chemical poison carbon tetrachloride (CCl4), thioacetamide(TAA), D-galactosamine(D-GalN), immunity hepatic injury model of mice induced by BCG and fat polysaccharide (LPS), chronic liver injury model of rats induced by CCI, were introduced in the experiment. The serum ALT and AST were measured in acute hepatic injury experiments. Serum ALT, AST, AKP, ALB, TP, BiL-T, ereatinine, triglyceride, sialie acid, larninin, hyaluronic acid, type Ⅲ proeollagen and type Ⅳ collagen, hepatic hydroxyproline (HyP) of rats in chronic liver injury animals were determined after Injection of the matrine hydrochloride. Results The Injection of the matrine hydrochloride reduced serum ALT and AST level of acute chemical liver injury of mice induced by CCl4, TAA and D-GaIN. The index of the liver and the spleen of immunity liver injury of mice induced by BCG and LPS were decreased after the injection of matrine hydrochloride treatment. Compared with the model group, the injection may obviously inhibited serum ALT, AST, TP, AKP, TRI, BiL-T, creatinine, triglyceride, sialic acid, laminin , hyaluronic acid , type Ⅲ procollagen and type Ⅳ collagen activity of chronic liver injury of rats induced by CCl4, elevated ALB、A/G, reduced the liver HyP, decreased the index of the liver and the spleen. The liver visual observation, the pathology inspection and the HAI grading result showed the injection may reduce the inflammatory activity in liver tissue, restrain the liver cell damage, reduce the pseudolobuli formation. Conclusions The Injection of matrine hydrochloride had the protective function to acute chemical hepatic injury of mice induced by CCl4、TAA、D-GalN、immunity hepatic injury of mice induced by the BCG and LPS and

  20. 盐酸坦索罗辛联合速尿在输尿管不同部位结石治疗中的疗效观察%Efficacy of tamsulosin hydrochloride with furosemide in the treatment of calculi in different parts of ureter Efficacy of tamsulosin hydrochloride with furosemide in the treatment of calculi in different parts of ureter

    Institute of Scientific and Technical Information of China (English)

    张自刚; 奚晓龙; 刘铁柱; 付毅; 杨亮; 邴建勇; 付继承; 朴庆华; 李秀凤

    2015-01-01

    Objective To explore the efficacy and side‐effect of tamsulosin hydrochloride with furosemide in the treat‐ment of calculi in different parts of ureter after extracorporeal shock wave lithotripsy (ESWL) .Methods Clinical data of 238 patients with ureteral stones treated during June 2010 and June 2014 were retrospectively analyzed .The patients were ran‐domly divided into observation group (n=120 ,55 with stones in middle or upper parts of ureter ,65 with stones in lower part of ureter) and control group (n=118 cases ,58 with stones in middle or upper parts of ureter ,60 with stones in lower part of ureter) .Patients in control group received treatment of furosemide ,while patients in observation group received treatment of tamsulosin hydrochloride with furosemide .The time of lithecbole ,stone clearance rate ,incidence and severity of pain ,condi‐tion of combined analgesics as well as side‐effect were compared between the two groups .Results There was no statistical difference between the size of lithiasis (P>0 .05) .The time of lithecbole in observation group was (5 .36 ± 2 .12)d in middle or upper parts of ureter and (4 .34 ± 2 .42)d in lower part of ureter ,which was shorter than that of the control group [(8 .76 ± 1.51)d and (7 .20 ± 1 .03)d ,respectively] .The difference had a statistical significance ( P0 .05) .Conclusions Oral tamsulosin hydrochloride plus intravenous furosemide after ESWL can effectively short‐en the time of lithecbole ,elevate the stone clearance rate ,reduce incidence rate of renal colic ,alleviate the severity of pain and does not intensify adverse reaction .It is safe and effective .%目的:研究盐酸坦索罗辛联合速尿注射液在体外冲击波碎石(ESWL)后治疗输尿管不同部位结石中的临床效果及不良反应。方法入组研究对象共238例,随机分为观察组(共120例,其中输尿管中上段结石55例,输尿管下段结石65例)与对照组(共118例,

  1. 固肾安胎丸联合盐酸利托君治疗先兆早产的疗效观察%Clinical observation of Gushen Antai Pills combined with ritodrine hydrochloride in treatment of threatened premature labor

    Institute of Scientific and Technical Information of China (English)

    邱星梅; 郑芳; 李伟娣; 郑慧频; 林新容

    2016-01-01

    目的:观察固肾安胎丸联合盐酸利托君治疗先兆早产的临床疗效。方法选择2014年6月—2015年6月四会市妇幼保健院妇产科收治的先兆早产患者102例,随机分为对照组和治疗组,每组各51例。对照组静脉滴注盐酸利托君注射液,100 mg用生理盐水500 mL稀释,直至达到预期效果。患者宫缩停止后,继续使用12 h,在停止静脉滴注前30 min用口服盐酸利托君片来巩固治疗。治疗组在对照组基础上口服固肾安胎丸,6 g/次,3次/d。两组均连续治疗2周。观察两组的保胎成功率、宫缩抑制显效时间、累积用药时间、孕期延长时间、自然分娩率,同时比较两组在治疗过程中的不良反应发生率。结果治疗后,对照组和治疗组的保胎成功率分别为70.6%、94.1%,自然分娩率分别为43.1%、76.5%,两组比较差异具有统计学意义(P<0.05)。治疗组宫缩抑制显效时间、累积用药时间均显著短于对照组,孕期延长时间长于对照组,两组比较差异有统计学意义(P<0.05)。对照组和治疗组的不良反应发生率分别为29.4%、7.8%,两组比较差异有统计学意义(P<0.05)。结论固肾安胎丸联合盐酸利托君治疗先兆早产具有很好的疗效,能够提高患者的保胎成功率,有利于孕妇自然分娩,具有一定的临床推广应用价值。%Objective To observe the clinical curative effect of Gushen Antai Pills combined with ritodrine hydrochloride in treatment of threatened premature labor. Methods Patients (102 cases) with threatened premature labor in Department of Obstetrics and Gynecology of Maternity and Child Care Hospital in Sihui City from June 2014 to June 2015 were randomly divided into control and treatment groups, and each group had 51 cases. The patients in the control group were iv administered with Ritodrine Hydrochloride Injection until the desired effect was achieved, 100 mg added into

  2. Vibrational spectra of pilocarpine hydrochloride crystals

    Energy Technology Data Exchange (ETDEWEB)

    Bento, R.R.F. [Universidade Federal de Mato Grosso (UFMT), Cuiaba, MT (Brazil). Inst. de Fisica; Freire, P.T.C. [Universidade Federal do Ceara (UFC), Fortaleza, CE (Brazil). Dept. de Fisica]. E-mail: tarso@fisica.ufc.br; Teixeira, A.M.R.; Silva, J.H. [Universidade Regional do Cariri, Crato, CE (Brazil). Dept. Ciencias Fisicas e Biologicas; Lima Junior, J.A. [Universidade Estadual do Ceara (UECE), Limoeiro do Norte, CE (Brazil); Oliveira, M.C.F. de; Andrade-Neto, M. [Universidade Federal do Ceara (UFC), Fortaleza, CE (Brazil). Dept. de Quimica Organica e Inorganica; Romero, N.R. [Universidade Federal do Ceara (UFC), Fortaleza, CE (Brazil). Dept. de Farmacia; Pontes, F.M. [Universidade Estadual Paulista, Bauru, SP (Brazil). Faculdade de Ciencias

    2009-03-15

    Pilocarpine is a natural substance with potential application in the treatment of several diseases. In this work Fourier Transform (FT)-Raman spectrum and the Fourier Transform infra red (FT-IR) spectrum of pilocarpine hydrochloride C{sub 11} H{sub 17} N{sub 2} O{sup +}{sub 2} .Cl{sup -1} were investigated at 300 K. Vibrational wavenumber and wave vector have been predicted using density functional theory (B3LYP) calculations with the 6-31 G(d,p) basis set. A comparison with experiment allowed to assign most of the normal modes of the crystal. (author)

  3. 盐酸左氧氟沙星对盆腔炎患者的临床治疗效果分析%Effect analysis of Levofloxacin Hydrochloride in the clinical treatment of patients with pelvic inflammatory dis-ease

    Institute of Scientific and Technical Information of China (English)

    万晓英; 张红娟; 刘丽芬

    2014-01-01

    Objective To explore the clinical effect of Levofloxacin hydrochloride in patients with pelvic inflammatory disease. Methods 100 patients were admitted to gynecological wards,using the method of randomization,they were divided into a control group and the obser-vation group,50 patients in each group. In the course of treatment,patients in the control group offloading treatment;observation group pa-tients with Levofloxacin hydrochloride for treatment. Respectively,in 10 days,20 days,30 days of treatment results were statistically evalua-ted two groups of patients,including patients with symptoms after treatment,signs and B- test results and other statistical analysis. Results The patients in 10 days,the treatment of 20 days,30 days were better than the control group,the difference was statistically significant( P<0. 05). Incidence of adverse reactions in patients in the control group was significantly higher than in the observation group,the difference was statistically significant(P<0. 05). Conclusion Compared with offloading,the more prominent of Levofloxacin hydrochloride in clinical outcomes in patients with gynecologic pelvic inflammatory disease,clinically can get comprehensive promotion and use.%目的:探究盐酸左氧氟沙星在盆腔炎患者的临床治疗效果。方法:选取妇科病房收治的100例患者,利用随机分组的方法,分为对照组与观察组,每组各50例患者。在治疗过程中,对照组患者应用氧氟沙星进行治疗;观察组患者应用盐酸左氧氟沙星进行治疗。分别在10 d、20 d、30 d对两组患者的治疗结果进行统计评价,包括患者治疗后的症状、体征以及B超的检查结果等进行统计学分析。结果:观察组患者在10 d、20 d、30 d的治疗结果均优于对照组,差异有统计学意义( P<0.05)。对照组患者不良反应发生率明显高于观察组,差异具有统计学意义( P<0.05)。结论:相对于氧氟沙星而言,盐酸

  4. 冠心病患者经盐酸替罗非班治疗的临床效果分析%Clinical Effect of Tirofiban Hydrochloride in the Treatment of Patients with Coronary Heart Disease

    Institute of Scientific and Technical Information of China (English)

    杨柳青

    2015-01-01

    目的:探讨冠心病患者经盐酸替罗非班治疗的临床疗效。方法研究对象为随机选取该院2013年2月—2015年2月冠心病患者100例,按照双盲法将100例冠心病患者随机分为对照组与观察组,每组50例。两组患者均接受经皮冠状动脉介入治疗,对照组低分子肝素治疗,观察组联合盐酸替罗非班治疗。观察两组患者临床疗效。结果经过治疗,对照组显效18例(36.00%),有效25例(50.00%),无效7例(14.00%),总有效率为86.00%;观察组显效45例(90.00%),有效4例(8.00%),无效1例(2.00%),总有效率为98.00%。观察组患者临床治疗效果明显优于对照组,差异具有统计学意义(P<0.05)。结论冠心病患者在经皮冠状动脉介入治疗联合盐酸替罗非班疗效显著,且术后不良反应发生率更低,值得进行临床推广应用。%Objective To study the clinical curative effect of tirofiban hydrochloride in the treatment of patients with coro-nary heart disease. Methods 100 cases of patients with coronary heart disease treated in our hospital from February 2013 to February 2015 were selected and randomly divided into the control group and observation group with 50 cases in each ac-cording to the double blind method. Both groups were given percutaneous coronary intervention treatment, on this basis , the control group were given additional low molecular weight heparin treatment and the observation group were given additional tirofiban hydrochloride treatment , clinical curative effect of the two groups was observed. Results After treatment, in the control group, 18 cases were markedly effective (36.00%), 25 cases were effective (50.00%), 7 cases were invalid (14.00%) and the total effective rate was 86.00%;in the observation group, 45 cases were markedly effective (90.00%), 4 cases were effective (8.00%), 1 case was invalid (2.00%) and the total effective rate was 98.00%. clinical

  5. Clinical Observation of Minocycline Hydrochloride Combined with Tinidazole in the Treatment of Chronic Periodontis%盐酸米诺环素联合替硝唑治疗慢性牙周炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    刘永; 王学侠

    2015-01-01

    目的:观察盐酸米诺环素联合替硝唑治疗慢性牙周炎的疗效和安全性。方法:100例慢性牙周炎患者随机均分为观察1组、观察2组、观察3组和对照组。对照组患者均给予龈上洁治、龈下刮治后,用0.9%氯化钠注射液和3%过氧化氢交替冲洗牙周袋底部;在此基础上,观察1组患者患牙隔湿、干燥后,缓慢注射盐酸米诺环素软膏深入牙周袋底部,至略有溢出,1次/周;观察2组患者给予替硝唑口腔贴片1片贴敷于患牙颊侧正中牙龈表面,2次/天;观察3组患者给予盐酸米诺环素软膏+替硝唑口腔贴片(用法用量同上述两组)。各组患者疗程均为4周。观察各组患者的临床疗效,治疗前后全口牙菌斑指数(PLI)、牙周附着水平(PAL)、牙周袋深度(PPD)、牙齿松动度(MD)、牙龈出血指数(GI)及不良反应发生情况。结果:观察3组患者总有效率>观察1组和观察2组>对照组,差异均有统计学意义(P<0.05),但观察1组、观察2组两组间比较,差异无统计学意义(P>0.05)。治疗后,各组患者PLI、PAL、PPD、MD、GI均显著低于同组治疗前,且观察3组<观察1组和观察2组<对照组,差异均有统计学意义(P<0.05),但观察1组、观察2组两组间比较,差异均无统计学意义(P>0.05)。各组患者治疗期间均未见明显不良反应发生。结论:盐酸米诺环素联合替硝唑治疗慢性牙周炎较单用盐酸米诺环素或替硝唑疗效更显著,安全性较好。%OBJECTIVE:To observe the efficacy and safety of minocycline hydrochloride combined with tinidazole in the treat-ment of chronic periodontitis. METHODS:100 patients with chronic periodontitis were randomly divided into observation group 1, observation group 2,observation group 3 and control group. Patients in control group were given full-mouth dental scalers and sub-gingival clean scraping

  6. 21 CFR 582.5676 - Pyridoxine hydrochloride.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Pyridoxine hydrochloride. 582.5676 Section 582.5676 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... Dietary Supplements 1 § 582.5676 Pyridoxine hydrochloride. (a) Product. Pyridoxine hydrochloride....

  7. Preparation and in vitro/in vivo evaluation of metformin hydrochloride rectal dosage forms for treatment of patients with type II diabetes.

    Science.gov (United States)

    Zaghloul, Abdel-Azim; Lila, Ahmad; Abd-Allah, Fathy; Nada, Aly

    2017-06-01

    Metformin hydrochloride (MtHCL) is an oral antidiabetic drug and has many other therapeutic benefits. It has poor bioavailability, narrow absorption window and extensive liver metabolism. Moreover, children and elders face difficulty to swallow the commercial oral tablets. Preparation, in vitro/in vivo evaluation of MtHCL suppositories for rectal administration to solve some of these problems. Suppository fatty bases (Witepsol(®), Suppocire(®) and Massa(®); different grades) and PEG bases 1000, 4000 and 6000 (different ratios), were used to prepare rectal suppository formulations each containing 500 mg drug. These were characterized for manufacturing defects, and pharmacotechnical performance and formulations showing superior results were subjected to bioavailability testing in human volunteers compared with the commercial oral tablet (Ref) applying LC-MS/MS developed analytical technique. The preparation method produced suppositories with satisfactory characteristics and free of manufacturing defects. The fatty bases were superior compared with PEG bases regarding the physical characteristics. Three formulations were chosen for bioavailability testing and the results showed comparable bioavailability compared to the Ref. The fatty bases showed superior characteristics compared with the PEG bases. MtHCL formulated in selected fatty bases could be a potential alternative to the commercial oral tablets particularly for pediatric and geriatric patients.

  8. 盐酸氨基葡萄糖治疗椎间盘源性腰痛的随机对照研究%Randomized Controlled Trials on Treatment of Discogenic Low Back Pain by Glucosamine Hydrochloride

    Institute of Scientific and Technical Information of China (English)

    张允; 曾喻; 冯静; 张林辉; 姜迎; 薛亮; 罗勇; 陈世寅

    2012-01-01

    目的 探讨单用和联用盐酸氨基葡萄糖与非甾体抗炎药(NSAID)在椎间盘源性腰痛(DLBP)治疗中的有效性.方法 2011年1月-12月72例DLBP患者,男42例,女30例;年龄22~71岁;体重43~84 kg;病程0.5~10年.通过随机数字表的方法,将患者分为3组.A组给予盐酸氨基葡萄糖胶囊750 mg,2次/d,同时给予尼美舒利分散片100 mg,2次/d;B组给予盐酸氨基葡萄糖胶囊750 mg,2次/d;C组给予尼美舒利分散片100 mg,2次/d.3组均用药8周后停药,用药期间停用其他活血化瘀类药物及物理治疗.选取治疗前及治疗后第4、8、16周4个时间点,运用疼痛数字评价量表(NRS)、Oswestry功能障碍指数(ODI)、生活质量评价量表SF-36分别对3组患者的腰痛、腰部功能及生活质量进行评价.结果 63例获得随访,失访率12.5%.各组患者NRS评分、ODI评分、SF-36评分在治疗前后比较差异均有统计学意义(P<0.05),A组疗效明显优于B、C两组,B组治疗后各项数据较治疗前明显改善(P<0.05).结论 单用盐酸氨基葡萄糖治疗DLBP有效,且在停药后,仍有一定疗效,联用NSAID效果更佳;远期疗效有待进一步随访.%Objective To investigate the curative effect of glucosamine hydrochloride or by glucosamine hydrochloride combined with non-steroid anti-inflammatory drug on discogenic low back pain (DLBP). Methods Between January and December 2011, 72 patients with DLBP (42 males and 30 females, 22-71 years old, 43-48 kg, disease course 0.5-10 years) were selected. They were randomly divided into group A, B, and C. Group A: 750 mg glucosamine hydrochloride combined with 100 mg Nimesulide Shulgin dispersible tablets, twice per day; group B: 750 mg glucosamine hydrochloride, twice per day; group C: 100 mg Nimesulide Shulgin dispersible tablets, twice per day. The treatment lasted for 8 weeks, and during this course, we stopped using Chinese medicines for promoting blood flow and eliminating blood stasis and

  9. Clinical analysis of diltiazem hydrochloride combined with nitroglycerin in the treatment of unstable angina pectoris%盐酸地尔硫和硝酸甘油联合治疗不稳定型心绞痛的效果

    Institute of Scientific and Technical Information of China (English)

    柳青; 李慧芳; 刘丽凤; 董瓅瑾

    2012-01-01

    Objective To observe the efficacy of injection of diltiazem hydrochloride combined with nitroglycerin in the treatment of unstable angina pectoris. Methods 101 patients with unstable angina pectoris in our hospital were randomly divided into test group (re =51) and control group (re = 50) . The test group was administered with diltiazem hydrochloride in combination with nitroglycerin while the control group was given nitroglycerin alone. After 48 hours, the two groups of patients were observed and compared in terms of anginal attacks, heart rate, Prt, Qrto, 01 interval time, blood pressure, myocardial oxygen consumption index, blood routine, blood biochemical index. JvesultS Ihere was no death, no complications or significant arrhythmias and hemodynamic changes. After treatment, the heart rate and myocardial oxygen consumption index of the test group decreased more significantly ( P < 0. 05 ) than in the control group. PR interval and QT interval of the test group were slightly longer than those of the control group, but without significant difference. Conclusion Injection of diltiazem hydrochloride combined with nitroglycerin in the treatment of unstable angina pectoris patients induces no serious adverse rectons and can effectively relieve angina,significantly reduce myocardial oxygen con- sumption and provide better myocardial protection.%目的 观察注射用盐酸地尔硫和硝酸甘油联合治疗不稳定型心绞痛的临床疗效.方法 选择我院住院的101例不稳定型心绞痛患者,随机分为实验组(n=51) 和对照组( n=50),对照组单用硝酸甘油,实验组应用硝酸甘油和盐酸地尔硫联合治疗.观察并比较两组患者用药48 h对心绞痛发作次数、心率、PR间期、QRS时限、QT间期、血压、心肌耗氧指标、血常规、血生化等指标.结果 两组均无并发症,无死亡,并且血流动力学的改变及心律失常的发生率差别均无统计学意义.实验组治疗后心率

  10. The clinical application of large dose of Ambroxol Hydrochloride for the treatment of ARDS in 1 case%大剂量氨溴索治疗ARDS的临床应用分析1例

    Institute of Scientific and Technical Information of China (English)

    白雪; 龙兴震; 谢娟

    2015-01-01

    本文通过临床药师对一例使用大剂量氨溴索治疗ARDS的案例进行疗效、不良反应的追踪及分析,并查阅国内外相关文献,得出大剂量氨溴索治疗ARDS的应用证据不足,特别是对其疗效是否呈剂量相关性、给药剂量、给药频次还缺乏大规模的实验研究。因此,临床上应谨慎使用。%In this paper, the clinical pharmacist using large dose of ambroxol hydrochloride in the treatment of acute respiratory distress syndrome (ARDS)for 1 case, curative effect and adverse reaction of were tracked and analyzed, and concluded that there is insufficient evidence for the application of large dose of ambroxol in the treatment of ARDS, especially no evidence for the effect-dose relationship, dose and dosing frequency from a large-scale experimental study. Therefore, it should be cautious in clinical use.

  11. Efficacy Comparison of Oxycodone Hydrochloride Controlled-release Tablets and Tramadol Hydrochloride Sustained-release Tablets in the Treatment of Moderate Cancer Pain%盐酸羟考酮缓释片与曲马多缓释片治疗中度癌痛的近期疗效比较

    Institute of Scientific and Technical Information of China (English)

    张锦丰; 杨权烈; 吴国武; 郭维新; 张英燕; 古银芳; 叶敏

    2014-01-01

    目的:比较盐酸羟考酮缓释片(奥施康定)与曲马多缓释片(奇曼丁)治疗中度癌痛的近期疗效。方法将100例伴有中度癌痛患者随机分为奥施康定组和奇曼丁组,每组50例,分别接受奥施康定和奇曼丁的治疗。结果奥施康定组治疗后第3、7、10天的NRS评分均较奇曼丁组低,且奥施康定组治疗后第3天NRS评分下降幅度较奇曼丁组明显( P﹤0.05);奥施康定组的CR率和有效率分别为34.0%和100.0%,明显高于奇曼丁组的10.0%和84.0%(P﹤0.05);2组毒副反应发生率比较差异均无统计学意义(P﹥0.05)。结论与奇曼丁相比,应用奥施康定治疗中度癌痛患者,能更快更有效缓解疼痛,而未增加毒副反应。%Objective To compare the efficacy and tolerability of oxycodone hydrochloride controlled-release tab-lets( oxycodone)and tramadol hydrochloride sustained-release tablets( tramadol)in the treatment of patients with moderate cancer pain. Methods A total of 100 patients with moderate cancer pain were randomly divided into two groups,50 patients of the oxycodone group was treated with oxycodone,and 50 patients of the tramadol group was treated with tramadol. Results The NRS scorce in the oxy-codone group had declined more significantly than the tramadol group,and the decrease was statistically significant in the first three days (P﹤0. 05). The CR rate and the response rate in the oxycodone group were significantly better than those of the tramadol group (34.0% vs10.0% and100.0% vs84.0%)(P﹤0.05).There was no statistic significant difference in the toxicity incidences be-tween the two groups(P﹥0. 05). Conclusion Compared with tramadol,oxycodone is faster and more effective to relieve pain,and don’t increase the toxicities.

  12. 盐酸吡利霉素治疗奶牛乳房炎临床药效学及对乳品质影响的研究%Studies on the Efficacy of Pirlimycin Hydrochloride for Mastitis Treatment and Milk Quality in Lactating Dairy Cows

    Institute of Scientific and Technical Information of China (English)

    徐鹏; 徐克范; 王烈滨

    2011-01-01

    The experiment was designed to study the efficacy of pirlimycin hydrochloride on mastitis treatment in lactating dairy cows. The results showed that the efficacy of pirlimycin hydrochloride for treatment of subclinical mastitis was better than ceftiofur sodium and compound amoxycillin. But for the treatment of clinical mastitis, the efficacy of compound amoxycillin was superior to pirlimycin hydrochloride and ceftiofur sodium. And the pirlimycin hydrochloride improved the milk quality better than ceftiofur sodium and compound amoxycillin(especially on decreasing somatic cell counts).%本研究依据对黑龙江省部分牧场奶牛乳房炎致病菌分离鉴定以及药敏试验结果,选取盐酸吡利霉素、头孢噻呋钠和复方阿莫西林为试验药物,对患有隐性乳房炎的奶牛进行治疗并对乳品质进行跟踪监测.结果表明盐酸吡利霉素对隐性乳房炎的治愈率最高,对临床型乳房炎的治疗效果略差于复方阿莫西林,盐酸吡利雷素与复方阿莫西林对两种类型乳房炎治疗的总有效率相当,但盐酸吡利霉素对乳品质(尤其是降低体细胞数方面)的改善作用显著好于复方阿莫西林治疗组.

  13. Glucosamine hydrochloride combined with celecoxib for the treatment of knee osteoarthritis:Randomized controlled trials%盐酸氨基葡萄糖联合塞来昔布治疗膝骨性关节炎的随机对照

    Institute of Scientific and Technical Information of China (English)

    李明辉; 刘洋; 王彩民; 游浩; 黄亮; 孙凯

    2013-01-01

    背景:盐酸氨基葡萄糖被认为具有治疗膝关节骨性关节炎的作用,但其是否对不同程度的骨性关节炎都有效,联合应用非类固醇类抗炎药与单用盐酸氨基葡萄糖是否存在疗效差别,尚需进一步临床研究。目的:采用前瞻性研究的方法对比单用盐酸氨基葡萄糖以及联合应用塞来昔布治疗不同程度膝关节骨性关节炎的临床疗效。方法:采用Lequesne评分将152例膝关节骨关节炎患者分为轻、中、重度,然后随机配比法均分为单用盐酸氨基葡萄糖组和盐酸氨基葡萄糖联合塞来昔布用药组,于用药后2,4,6周以及停药8,12周统计患者Lequesne评分,用药前后及组间进行对比并统计盐酸氨基葡萄糖的不良反应。结果与结论:在轻度骨性关节炎治疗组中,盐酸氨基葡萄糖组治疗4周、停药12周后Lequesne评分与治疗前比较,差异有显著性意义;而联合用药组治疗2周后评分即有改善,两组比较,评分在治疗2,4周差异有显著性意义,说明联合用药组效果改善更显著;中度骨性关节炎患者在治疗2,4,6周和停药8周时,联合用药患者Lequesne评分均低于单纯使用盐酸氨基葡萄糖患者,差异均有显著性意义(P<0.05),说明在中度骨性关节炎,盐酸氨基葡萄糖联合塞来昔布治疗效果好于单独用药;重度骨性关节炎中,两组治疗后Lequesne评分与治疗前比较,均无明显改善。结果说明对于轻度膝骨性关节炎,单用盐酸氨基葡萄糖口服即可明显改善患者临床症状,对于中度膝骨关节炎,建议联合非类固醇类抗炎药类用药,可以较好改善临床症状,而对于重度膝骨关节炎,两种方法均无效。%BACKGROUND:Glucosamine hydrochloride is considered to have the role in the treatment of knee osteoarthritis. Whether it is effective for varying degrees of osteoarthritis and whether there are

  14. Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance

    OpenAIRE

    Zhi-Gang Cheng; Xu-Yong Dai; Li-Wei Li; Qiong Wan; Xiang Ma; Guang-Ya Xiang

    2014-01-01

    Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm × 4.6 mm, 5 µm). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR)...

  15. Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance

    OpenAIRE

    Cheng, Zhi-Gang; Dai, Xu-Yong; Li, Li-Wei; Wan, Qiong; Ma, Xiang; Xiang, Guang-Ya

    2014-01-01

    Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm × 4.6 mm, 5 µm). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR). ...

  16. Chemical Immobilization of Sloth Bears (Melursus ursinus) with Ketamine Hydrochloride and Xylazine Hydrochloride: Hematology and Serum Biochemical Values.

    Science.gov (United States)

    Veeraselvam, M; Sridhar, R; Perumal, P; Jayathangaraj, M G

    2014-01-01

    The present study was conducted to define the physiological responses of captive sloth bears immobilized with ketamine hydrochloride and xylazine hydrochloride and to determine and compare the values of hematology and serum biochemical parameters between sexes. A total of 15 sloth bears were immobilized using combination of ketamine hydrochloride and xylazine hydrochloride drugs at the dose rate of 5.0 milligram (mg) per kg body weight and 2.0 mg per kg body weight, respectively. The use of combination of these drugs was found satisfactory for the chemical immobilization of captive sloth bears. There were no significant differences observed in induction time and recovery time and physiological parameters such as heart rate, respiratory rate, and rectal temperature between sexes. Health related parameters comprising hematological values like packed cell volume (PCV), hemoglobin (Hb), red blood cell count (RBC), erythrocyte indices, and so forth and biochemical values like total protein, blood urea nitrogen (BUN), creatinine, alkaline amino-transferase (ALT), aspartate amino-transferase (AST), and so forth were estimated in 11 (5 males and 6 females) apparently healthy bears. Comparison between sexes revealed significant difference in PCV (P sloth bears for appropriate line treatment.

  17. Chemical Immobilization of Sloth Bears (Melursus ursinus with Ketamine Hydrochloride and Xylazine Hydrochloride: Hematology and Serum Biochemical Values

    Directory of Open Access Journals (Sweden)

    M. Veeraselvam

    2014-01-01

    Full Text Available The present study was conducted to define the physiological responses of captive sloth bears immobilized with ketamine hydrochloride and xylazine hydrochloride and to determine and compare the values of hematology and serum biochemical parameters between sexes. A total of 15 sloth bears were immobilized using combination of ketamine hydrochloride and xylazine hydrochloride drugs at the dose rate of 5.0 milligram (mg per kg body weight and 2.0 mg per kg body weight, respectively. The use of combination of these drugs was found satisfactory for the chemical immobilization of captive sloth bears. There were no significant differences observed in induction time and recovery time and physiological parameters such as heart rate, respiratory rate, and rectal temperature between sexes. Health related parameters comprising hematological values like packed cell volume (PCV, hemoglobin (Hb, red blood cell count (RBC, erythrocyte indices, and so forth and biochemical values like total protein, blood urea nitrogen (BUN, creatinine, alkaline amino-transferase (ALT, aspartate amino-transferase (AST, and so forth were estimated in 11 (5 males and 6 females apparently healthy bears. Comparison between sexes revealed significant difference in PCV (P<0.05 and mean corpuscular hemoglobin concentration (MCHC (P<0.05. The study might help to evaluate health profiles of sloth bears for appropriate line treatment.

  18. Cartap hydrochloride poisoning: A clinical experience

    OpenAIRE

    Hari K Boorugu; Anugrah Chrispal

    2012-01-01

    Cartap hydrochloride, a nereistoxin analog, is a commonly used low toxicity insecticide. We describe a patient who presented to the emergency department with alleged history of ingestion of Cartap hydrochloride as an act of deliberate self-harm. The patient was managed conservatively. To our knowledge this is the first case report of Cartap hydrochloride suicidal poisoning. Cartap toxicity has been considered to be minimal, but a number of animal models have shown significant neuromuscular to...

  19. 壳聚糖抗菌凝胶联合盐酸环丙沙星栓治疗需氧菌阴道炎疗效分析%Efficacy Analysis on Treatment of Aerobic Vaginitis by Chitosan Antibacte-rial Gel Combined with Ciprofloxacin Hydrochloride Suppositories

    Institute of Scientific and Technical Information of China (English)

    廖小倩; 林秀梅; 叶青剑; 黄敏

    2016-01-01

    目的:探讨壳聚糖抗菌凝胶联合盐酸环丙沙星治疗需氧性阴道炎(AV)的疗效。方法整群选取2015年11月—2016年3月期间该院诊治的82例AV患者随机分为研究组和对照组,研究组41例,对照组41例。研究组给予壳聚糖抗菌凝胶和盐酸环丙沙星栓,对照组给予盐酸环丙沙星栓剂治疗,观察两组疗效。结果治疗7 d后,两组治疗AV的总有效率分别为95.1%和78.0%(P﹤0.05)。结论壳聚糖抗菌凝胶联合盐酸环丙沙星治疗AV效果更好,值得临床推广。%Objective To observe the efficacy of treatment of aerobic vaginitis by chitosan antibacterial gel with ciprofloxacin hydrochloride suppositories. Methords Group selection 82 patients at our hospital from November 2015 to March 2016 with aerobic vaginitis are randomly divided into the research group (41cases) and the control group (41cases). Chitosan antibacterial gel with ciprofloxacin hydrochloride suppositories are administered to the research group while only ciprofloxacin hydrochloride suppositories are administered to the control group, to observe the efficacy of both two groups. Results The total therapy effective rates of the two groups are 95.1% and 78.0%(P﹤0.05), respectively. Conclusion The ap-plication of chitosan antibacterial gel with ciprofloxacin hydrochloride suppositories generates better efficacy in the treat-ment of aerobic vaginitis and is thus worth clinical promotion.

  20. 21 CFR 522.1222b - Ketamine hydrochloride with promazine hydrochloride and aminopentamide hydrogen sulfate injection.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Ketamine hydrochloride with promazine... RELATED PRODUCTS IMPLANTATION OR INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS § 522.1222b Ketamine.... Ketamine hydrochloride, (±),-2-(o-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride, with promazine...

  1. 盐酸氢吗啡酮注射液治疗慢性疼痛的有效性:meta分析%Efficacyof hydromorphone hydrochloride injection for treatment of chronic pain : a meta-analysis

    Institute of Scientific and Technical Information of China (English)

    曾铮; 武庆平; 姚尚龙; 尹平; 付阿丹

    2015-01-01

    目的 采用meta分析评价盐酸氢吗啡酮注射液治疗慢性疼痛的有效性.方法 检索Web of Science Proceedings和PubMed数据库,无语种和发表时间限制.收集评价盐酸氢吗啡酮注射液治疗慢性疼痛有效性的临床研究.主要评价指标包括:VAS评分、疼痛控制率或缓解率等.由2名研究人员独立地筛选研究并提取数据,并利用Stata 10软件进行数据分析.结果 最终共11项研究符合纳入标准,共452例患者.与治疗前比较,盐酸氢吗啡酮注射液治疗后VAS评分降低(P<0.05).对于癌性疼痛患者,与其他阿片类镇痛药比较,盐酸氢吗啡酮注射液治疗后VAS评分降低,疼痛缓解率或控制率升高(P<0.05).结论 盐酸氢吗啡酮注射液可治疗慢性疼痛,其对癌性疼痛患者的治疗效果可能优于其他阿片类镇痛药物.%Objective To systematically review the efficacy of hydromorphone hydrochloride injection for treatment of chronic pain.Methods Web of Science Proceedings and PubMed were searched for clinical trials involving the efficacy of hydromorphone for treatment of chronic pain, with no language or time limit.Evaluation indexes included visual analogue scale (VAS) score and the rate of pain control or relief.The studies were screened independently, and the data were extracted by two researchers.Meta-analysis was conducted using the Stata 10 software.Results Eleven studies involving 452 patients were included in our meta-analysis.VAS score was significantly decreased after treatment compared with that before treatment.For the patients with cancer pain, VAS score was significantly decreased after treatment with hydromorphone hydrochoride injection, and the rate of pain control or relief was increased when compared with the other opioid analgesics.Conclusion Hydromorphone hydrochloride injection can treat chronic pain, and it may provide better therapeutic effect than the other opioid analgesics for the patients with cancer pain.

  2. Clinical effect of venlafaxine combined with methylphenidate hydrochloride on narcolepsy

    Directory of Open Access Journals (Sweden)

    YAN Bin

    2013-11-01

    Full Text Available This study aims to explore the clinical effect of venlafaxine sustained-release capsules combined with methylphenidate hydrochloride tablets on narcolepsy. Thirty-eight cases of narcoleptic patients were randomly divided into venlafaxine combined with methylphenidate hydrochloride treatment group (observation group, N = 19 and methylphenidate hydrochloride and clomipramine treatment group (control group, N = 19. After a total of 12-week treatment, clinical curative effect and adverse drug reactions were observed in 2 groups of patients. The results showed that effective rate of the treatment for excessive daytime sleepiness (EDS in observation group was higher than that of the control group (15/19 vs 8/19, P = 0.044, and effective rate of the treatment for cataplexy in observation group was higher than that of the control group (13/19 vs 6/19, P = 0.048. The rate of adverse drug reactions in observation group was lower than that in the control group (χ2 = 8.889, P = 0.003. It was indicated that venlafaxine combined with methylphenidate had good curative effect on narcolepsy with EDS and cataplexy symptoms.

  3. Thermoanalytical Investigation of Terazosin Hydrochloride

    OpenAIRE

    Mona Mohamed Abdel-Moety; Ali Kamal Attia

    2013-01-01

    Purpose: Thermal analysis (TGA, DTG and DTA) and differential scanning calorimetry (DSC) have been used to study the thermal behavior of terazosin hydrochloride (TER). Methods: Thermogravimetric analysis (TGA/DTG), differential thermal analysis (DTA) and differential scanning calorimetry (DSC) were used to determine the thermal behavior and purity of the used drug. Thermodynamic parameters such as activation energy (E*), enthalpy (∆H*), entropy (∆S*) and Gibbs free energy change of the decomp...

  4. Effects of electroacupuncture on the expression of key mRNA related to TLR7 signaling pathway in the spleen of insomnia rats induced by PACA%电针对 PCPA 致失眠大鼠脾脏 TLR7信号通路关键基因 mRNA 表达的影响

    Institute of Scientific and Technical Information of China (English)

    何华香; 赵仓焕; 陆雪; 陈孝银; 林炎龙

    2015-01-01

    目的:观察电针对对氯苯丙氨酸(PCPA)致失眠大鼠脾脏 Toll 样受体7(TLR7)信号通路关键基因 mR-NA 表达的影响,探讨电针治疗失眠的免疫学机制.方法:取健康 SPF 级 Wistar 雄性大鼠32只,随机分成空白组、模型组、电针组和安定组,每组8只.模型组以腹腔注射 PCPA 建立大鼠失眠模型,安定组给予腹腔注射安定,电针组给予电针神门(HT7)、三阴交(SP6)穴位,连续治疗5 d 后用实时荧光定量 PCR(RT-PCR)反应测定大鼠脾脏TLR7、髓样分化蛋白88(MyD88),IL-1受体相关激酶4(IRAK4)、肿瘤坏死因子相关激酶6(TRAF6)、及核因子 NF-κB(NF-κB)的 mRNA 表达.结果:与空白组对照,模型组 TLR7、MyD88、IRAK4及 TRAF6的 mRNA 表达增加(P <0.05);与模型组比较,电针组、安定组 IRAK4、TRAF6及 NF-kB 的 mRNA 表达降低,电针组 TLR7及 MyD88的 mRNA表达降低(P <0.05),但电针组与安定组比较,无统计学差异(P >0.05).结论:失眠上调 TLR7信号转导通路关键基因 mRNA 表达,TLR7可能参与免疫对睡眠的调节;电针可通过调节 TLR7信号转导通路调控相关免疫物质的释放,改善睡眠及减轻失眠对机体带来的损伤.%Aim:The objective is to observe the effects of electroacupuncture on the expression of the key genes related to TLR7 signaling pathway in the spleen of insomnia rats induced by PCPA,and to in-vestigate the immunologic mechanism of electroacupuncture in treatment of insomnia.Methods:Thirty-two healthy Wistar rats were randomly divided into four groups:bland group,model group,electroacu-puncture group and diazepam group,with 8 rats in each one.The insomnia rats in the model group were established by intraperitoneal injection of para-chlorophenylalanine(PCPA).The rats of electroacupunc-ture group were treated with electroacupuncture at Shenmen and Sanyinjiao.The rats of diazepam group

  5. Dobutamine Hydrochloride Injection

    Science.gov (United States)

    ... effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments ... health care provider as soon as possible: tenderness warmth irritation drainage redness swelling pain ¶ These branded products ...

  6. Application of Minocycline Hydrochloride Ointment in the Treatment of Periodontitis%盐酸米诺环素软膏在牙周炎治疗中的应用分析

    Institute of Scientific and Technical Information of China (English)

    徐波

    2015-01-01

    Objective The clinical efficacy of Periocline(Minocycline hydrochloride ointment) in treatment of periodontitis is to be analyzed.MethodsChoose 91 patients with periodontitis who are treated in hospital from September 2013 to September 2014 and separate them into iodine glycerin group and periocline group,and then compare the PD(Periodontal probing depth),PLI(Plaque Index),SBI(Sulcus bleeding index)data changes and treatment efficacy of two groups before and after treatment.Results The numerical data of PD,PLI,SBI in periocline group are much lower than iodine glycerin group,however,the treatment efficiency in periocline group are much higher than iodine glycerin group,and such a treatment differential has statistic value(P<0.05).Conclusion Periocline treatment is effective to improve patients’ clinical symptoms and their periodontitis index. And it is simple,economic and safe to use with high efficiency,therefore,it is quite worthwhile to be promoted.%目的分析牙周炎治疗中应用派力奥(盐酸米诺环素软膏)的临床疗效。方法选取2013年9月~2014年9月间我院收治的牙周炎患者91例,分为碘甘油组与派力奥组,对比治疗前后两组PD(牙周探诊深度)、PLI(菌斑指数)、SBI(龈沟出血指数)变化与临床效果。结果派力奥组患者PD、PLI、SBI值与碘甘油组相比明显较低,总有效率(95.74%)相对较高,两组临床疗效差异显著,有统计学意义(P<0.05)。结论牙周炎治疗中应用派力奥可以有效改善临床症状与牙周指数,简便经济,有效安全。

  7. Clinical Observation on the Effect of Different Doses of Ambroxol Hydrochloride in the Treatment of Senile Pneumonia%不同剂量盐酸氨溴索治疗老年人肺炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    匡鹏; 薛立江

    2014-01-01

    Objective To observe on the basis of conventional drugs with dif erent doses of hydrochloric acid ammonia bromine somalia's clinical curative ef ect for the treatment of pneumonia in the elderly. Methods 253 cases by 65~80 years old aged pneumonia patients applies dif erent doses of ammonia bromine hydrochloride combined with conventional drug treatment, the control group, low dose treatment group, high dose treatment group curative ef ect comparison. Results Is high, low dose of hydrochloric acid ammonia bromine line combined with conventional drugs for the treatment of pneumonia in the elderly has significant curative ef ect, show the ef iciency of 43.6%, total ef ective rate 73.12%, can effectively reduce the number of sputum in medium and smal airway stranded, reduce airflow obstruction, safeguard the respiratory tract, usual y lower airway inflammation high reactivity, improve the elasticity of alveolar and function, improve curative ef ect, reduce the case fatality rate, reduce the length of hospital stay. Conclusion High dose hydrochloric acid ammonia bromine in combination with conventional drug treatment of pneumonia in the elderly curative ef ect is distinct, less adverse reaction.%目的:观察在常规药物的基础上加上不同剂量的盐酸氨溴索治疗老年人肺炎的临床疗效。方法通过253例65~80岁老年肺炎患者应用不同剂量的盐酸氨溴索结合常规药物治疗,对对照组、低剂量治疗组、高剂量治疗组进行疗效比较。结果高、低剂量的盐酸氨溴索结合常规药物对老年人肺炎治疗有显著疗效,显效率43.6%,总有效率73.12%,能有效地减少痰液在中小气道的滞留,保持呼吸道通常,降低气道炎症高反应性,提高肺泡弹性及肺泡功能,提高疗效,降低病死率。结论高剂量盐酸氨溴索结合常规药物治疗老年人肺炎疗效显著,不良反应少。

  8. A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome.

    Science.gov (United States)

    Chen, Chunqiu; Tao, Chunhua; Liu, Zhongchen; Lu, Meiling; Pan, Qiuhui; Zheng, Lijun; Li, Qing; Song, Zhenshun; Fichna, Jakub

    2015-11-01

    We aimed to evaluate clinical symptoms in diarrhea predominant irritable bowel syndrome (IBS-D) receiving berberine hydrochloride in a randomized double-blind placebo-controlled clinical trial. Overall, 196 patients with IBS-D were recruited for this study; consequently, 132 patients randomized to receive daily 400 mg of berberine hydrochloride, delivered twice daily or placebo for 8 weeks followed by a 4-week washout period. After a 2-week run-in period, diarrhea, abdominal pain, urgent need for defecation frequency and any adverse events were recorded daily. Prior to administration of the medication and after completing the treatment, assessment of IBS symptom scores, depression and anxiety scale scores and the IBS scale for quality of life (QOL) was carried out. The effects of berberine hydrochloride on IBS-D, defined by a reduction of diarrhea frequency (P = 0.032), abdominal pain frequency (P berberine group than the placebo group in the 8 weeks of treatment. A trend of improvement (P berberine hydrochloride for IBS symptom score, depression score and anxiety score and the IBSQOL, compared with placebo. At last, berberine hydrochloride was well tolerated. So we concluded that berberine hydrochloride is well tolerated and reduces IBS-D symptoms, which effectively improved patients QOL.

  9. 多奈哌齐联合盐酸美金刚治疗阿尔茨海默病的临床研究%Clinical Study of Donepezil and Memantine Hydrochloride in the Treatment of Alzheimer's Disease

    Institute of Scientific and Technical Information of China (English)

    王雪

    2015-01-01

    目的:探讨多奈哌齐联合盐酸美金刚治疗阿尔茨海默病的的临床疗效和安全性。方法78例阿尔茨海默病患者随机分为观察组与对照组两组各39例,观察组患者采用多奈哌齐联合盐酸美金刚治疗,对照组患者采用多奈哌齐治疗,采用AD 评估量表-认知部分(ADAS-cog)、简易智能精神状态检查量表(MMSE)和日常生活活动能力量表(ADL)评定患者治疗前后的临床效果。结果治疗后,两组患者ADAS-cog、MMES和ADL量表评分与治疗前相比均有所改善(P<0.05);观察组患者改善效果好于对照组(P<0.05)。两组不良反应发生情况相比差异无统计学意义(P>0.05)。结论多奈哌齐联合盐酸美金刚治疗阿尔茨海默病疗效显著,能显著改善患者的认知功能和行为能力,并且具有良好的安全性。%Objective To explore the clinical effects and security of donepezil combined with memantine in the treatment of alzheimer’s disease. Methods78 cases of Alzheimer's disease patients were randomly divided into observation group and control group 39 cases in each group, the patients in the observation group with donepezil and memantine hydrochloride in the treatment and control group were treated with donepezil, table - cognitive (ADAS-cog), Mini Mental State Examination (MMSE) and activities of daily living ability scale (ADL) before and after treatment in patients with the clinical effect assessment by the assessment.ResultsAfter treatment, The scores of ADAS-cog, MMSE and ADL were improved in both groups (P0.05).Conclusion Donepezil combined with memantine in the treatment of alzheimer’s disease has signiifcant curative effect, can signiifcantly improve the patients' cognitive function and behavior ability, and good security.

  10. Comparative study of penehyclidime hydrochloride and atropine in treatment of acute organophosphate pesticide poisoning%盐酸戊乙奎醚与阿托品治疗急性有机磷农药中毒疗效比较研究

    Institute of Scientific and Technical Information of China (English)

    朱艳霞; 杨贤义; 肖敏

    2012-01-01

    Objective To compare the clinical efficacy of penehyclidime hydrochloride and atropine in treatment of a-cute organophosphate pesticide poisoning. Methods Totally 76 patients within six hours of organophosphorus pesticide poisoning were randomly divided into penehyclidime hydrochloride group (re = 38) and atropine group ( n = 38 ),they were all combined with pralidoxime chloride,different doses of penehyclidime hydrochloride and atropine were given according to difference degrees of severity which was ranged in terms of cholinesterase value. The clinical efficacy of two groups was compared. Results The penehyclidime hydrochloride group,the poisoning symptoms time,cuative time and CHE recovery time were compared with that of the atropine group,the difference was statistically significant (P < 0. 01) ; The incidence rate of adverse reactions significantly less than that of the atropine group ( P < 0. 01). Conclusion Penehyclidime hydrochloride in treatment of acute organophosphate pesticide poisoning is safer and more effective than atropine.%目的 比较盐酸戊乙奎醚与阿托品治疗急性有机磷农药中毒的临床疗效.方法 76例6h内有机磷农药中毒者随机分成盐酸戊乙奎醚组(38例)和阿托品组(38例),均配伍用氯解磷定,分别按照胆碱酯酶数值划分的轻中重度程度,给予不同剂量的盐酸戊乙奎醚及阿托品,比较两组患者的临床疗效.结果 盐酸戊乙奎醚组的中毒症状消失时间、治愈时间、CHE恢复时间与阿托品组比较,差异均有统计学意义(P<0.01);并且不良反应的发生率明显比阿托品组低(P<0.01).结论 盐酸戊乙奎醚治疗急性有机磷农药中毒疗效确切,不良反应少,优于阿托品.

  11. 多巴丝肼片及吡拉西坦治疗帕金森病的疗效比较%Clinical Efficacy of Levodopaand Benserazide Hydrochlo-ride and Piracetam in the Treatment of Parkinson Disease

    Institute of Scientific and Technical Information of China (English)

    范金英

    2014-01-01

    Objective To observe the clinical efficacy of levodopaand benserazide hydrochlo-ride and piracetam in the treatment of Parkinson disease. Methods 80 patients with Parkinson disease were admitted to our hospital from August 2010 to August 2013,were divided into the experimental group and the control group randomly,40 cases of each group. The control group was given piracetam,the experimental group was given levodopaand benserazide hydrochlo-ride,the clinical effi-cacy of two groups were compared. Results The total improvement rate(80%)of experimental group was higher than control group(40%),the difference was statistically significant(P ﹤0. 05). Conclusion Levodopaand benserazide hydrochlo -ride treating Parkinson disease,which can effectively improve the clinical symptoms,the actual value is obvious.%目的:观察多巴丝肼片及吡拉西坦治疗帕金森病( PD)的临床疗效。方法选取本院2010年8月-2013年8月的收治的80例PD患者,将其随机分为试验组和对照组,各40例。对照组患者口服吡拉西坦治疗,试验组患者给予多巴丝肼片治疗治疗,比较两组患者的临床治疗效果。结果试验组患者的总改善率(80%)高于对照组(40%),差异有统计学意义( P﹤0.05)。结论对帕金森患者采用多巴丝肼片治疗,可以有效改善患者的临床症状。

  12. Analysis and clinical treatment of respiratory tract spasms induced by tramadol hydrochloride%盐酸曲马多导致呼吸道痉挛的药学分析与临床处理

    Institute of Scientific and Technical Information of China (English)

    张文静; 万思慧; 王卓; 夏阳; 白冲

    2014-01-01

    1例气管腺样囊腺癌术后患者超剂量使用盐酸曲马多后出现气喘和气急症状。临床药师通过对其进行重点药学监护,查阅国内外相关文献,发现超剂量(>1000 mg·d-1)或肝功能受损患者使用盐酸曲马多后可能会出现呼吸系统症状,表现为气喘、气急以及呼吸抑制症状。并对曲马多药理学机制及其不良反应处置、体内药代动力学特点等进行分析。患者停用曲马多后,气喘、气急症状得以缓解。%One tracheal adenoid cystic carcinoma patient after surgical operation developed asthma and shortness of breath because of over dose use of tramadol hydrochloride. The clinical pharmacists took pharmaceutical care for this speciifc case. According to literature from domestic and aboard, the patient using high dose of tramadol (>1000 mg·d-1) or the patient using tramadol with liver injury could develop asthma, shortness of breath and respiratory depression symptoms. The pharmacists discussed the pharmacology and pharmacokinetics of tramadol and treatment of adverse drug reaction caused by tramadol with doctors. Symptoms of asthma and shortness of breath eventually relieved after withdrawal of tramadol.

  13. Effect of sertraline hydrochloride on dialysis hypotension.

    Science.gov (United States)

    Dheenan, S; Venkatesan, J; Grubb, B P; Henrich, W L

    1998-04-01

    Hemodialysis hypotension (HH) is a very common disorder and has a multifactorial etiology. Autonomic dysfunction occurs in up to 50% of patients with end-stage renal disease (ESRD) and plays a key role in HH in some patients. Sertraline hydrochloride, a central nervous system serotonin reuptake inhibitor, has been shown to be an effective treatment of hypotension caused by autonomic dysfunction in disorders such as neurocardiogenic syncope and idiopathic orthostatic hypotension. This study sought to determine whether sertraline was effective in ameliorating HH. A retrospective chart analysis was performed that included nine consecutive patients (aged > or = 54 years, time on hemodialysis > or = 2.2 years) placed on sertraline (50 to 100 mg/d) for depression who also had HH (defined as prehemodialysis systolic blood pressure [SBP] or = 40 mm Hg decrease in SBP during hemodialysis, SBP sertraline. The data from a 6-week pre-sertraline period were compared with the data from a 6-week sertraline period (defined as 6 weeks after drug begun). Blood pressure medications were unchanged during the trial period of sertraline. However, nadir mean arterial pressure recorded during a given dialysis session in the pre-sertraline period (55+/-4 mm Hg) was significantly lower than that recorded in the sertraline period (68+/-5 mm Hg; P sertraline period was significantly lower than that during the pre-sertraline period (mean, 0.6+/-0.2 episodes per session v 1.4+/-0.3 episodes per session; P sertraline period was also significantly less than that during the pre-sertraline period (mean, 1.7+/-0.8 interventions v 11.0+/-3.0 interventions; P sertraline hydrochloride reduces HH in some patients with ESRD. A possible mechanism for this effect is sertraline-induced attenuation of the paradoxical sympathetic withdrawal that may underlie HH in some patients with ESRD.

  14. Cinacalcet hydrochloride (Sensipar)

    Science.gov (United States)

    2005-01-01

    Currently, >300,000 patients with end-stage renal disease require dialysis. Secondary hyperparathyroidism is a serious complication of end-stage renal disease and can lead to renal osteodystrophy and other organ failure. Vitamin D sterols and phosphate binders are used to treat hyperparathyroidism, but they can cause hypercalcemia, which contributes to vascular and soft-tissue calcification. Cinacalcet (Sensipar) is the first agent in its class that treats secondary hyperparathyroidism by increasing the sensitivity of calcium sensing receptors. It is also indicated for the treatment of hypercalcemia in patients with parathyroid carcinoma. All clinical trials concluded that cinacalcet is effective for the reduction of parathyroid hormone, serum calcium, phosphorus, and calcium-phosphate product levels. Cinacalcet is available as a once-daily oral therapy. Adverse effects are generally mild. PMID:16200170

  15. Effect of shufengjiedu capsule combined with compound paracetamol and amantadine hydrochloride capsule in the treatment of inlfuenza-like illness in the university students%疏风解毒胶囊联合复方氨酚烷胺胶囊治疗大学生流感样疾病疗效

    Institute of Scientific and Technical Information of China (English)

    夏建珍

    2016-01-01

    Objective: To evaluate the clinical efifcacy and safety of shufengjiedu capsule combined with compound paracetamol and amantadine hydrochloride capsule in the treatment of inlfuenza-like illness in the university students.Methods:Three hundred university students with influenza-like illness were selected and randomly divided into a treatment group of shufengjiedu capsule combined with compound paracetamol and amantadine hydrochloride capsule and a control group of compound paracetamol and amantadine hydrochloride capsule only. The treatment group was received one capsule of compound paracetamol and amantadine hydrochloride capsule, twice daily, meanwhile, added with 4 capsules of shufengjiedu capsule, thrice daily. The control group was received one capsule of compound paracetamol and amantadine hydrochloride capsule, twice daily. The symptoms of temperature and sore throat/cough, the treatment efifcacy and safety were observed in the two groups after three days treatment.Results:The total effective rate was 94.2% and 87.5% in the treatment and the control groups, respectively. The difference between the two groups had the statistical signiifcance(P<0.05).Conclusion: Shufengjiedu capsule combined with compound paracetamol and amantadine hydrochloride capsule in the treatment of inlfuenza-like illness in the university students has signiifcant effect which can effectively alleviate the symptoms of patients and promotes the rehabilitation.%目的:评价疏风解毒胶囊联合复方氨酚烷胺胶囊治疗大学生流感样疾病的临床疗效和安全性。方法:选取大学生流感样病例患者300例,随机分为疏风解毒胶囊联合复方氨酚烷胺胶囊治疗组(治疗组)和单用复方氨酚烷胺胶囊治疗组(对照组)。治疗组口服复方氨酚烷胺胶囊1粒,每天2次,加用疏风解毒胶囊口服4粒,每天3次;对照组口服复方氨酚烷胺胶囊1粒,每天2次。观察两组治疗后3 d的体温、咽痛/咳

  16. The use of xylazine hydrochloride in an analgesic protocol for claw treatment of lame dairy cows in lateral recumbency on a surgical tipping table.

    Science.gov (United States)

    Rizk, Awad; Herdtweck, Sarah; Offinger, Jennifer; Meyer, Henning; Zaghloul, Adel; Rehage, Juergen

    2012-05-01

    The objective of this study was to investigate the effect of xylazine on the stress and pain response of lame cows undergoing claw treatment in lateral recumbency (LR). Twenty-four lame, German Holstein-Friesian cows were included in a prospective, blinded, placebo-controlled clinical case study. Cows were randomly allocated to two groups (n=12) and either treated with xylazine (0.05 mg/kg BW, i.m.) or an equal volume of saline (controls) 15 min before placing them in LR. Before surgical treatment, each cow received retrograde intravenous local anaesthesia (LA). Over a period of 6h, heart rate (HR), respiratory rate (RR), plasma concentrations of cortisol, glucose, lactate and non-esterified fatty acids (NEFA) were determined at preset time intervals and the animals' behaviour was recorded via video recording and pedometer. All xylazine-treated cows showed signs of mild sedation, a reduced pain response on insertion of the needle for LA, reduced ear flicking during surgery, reduced lameness score and longer standing periods as well as improved appetite in the first hour postoperatively. Mean HR and RR, as well as plasma concentrations of NEFA were significantly reduced after xylazine treatment. Cortisol concentrations were significantly lower in xylazine-treated cows after being placed in LR but were similar to controls during surgery. The use of a low dose of xylazine in the analgesic protocol for the treatment of lame cows in LR alleviates stress and potentiates the analgesic effects of LA. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. [Clinical evaluation of roxatidine acetate hydrochloride injection as preanesthetic medication].

    Science.gov (United States)

    Kawanishi, M; Enomoto, A; Shimada, Y; Kurokawa, Y

    1991-09-01

    The effects of single intravenous administration of roxatidine acetate hydrochloride 75 mg on the volume and pH of gastric juice were investigated in 43 patients undergoing elective surgery under general anesthesia. The drug was given 1 hour before anesthesia. The percentages of patients with gastric pH above 2.5 and gastric juice volume under 25 ml were 95.3% and 97.7% at the time of induction of anesthesia and at the time of extubation, respectively. As for overall assessment on gastric secretion, 93.0% was judged as very effective. In 2 cases, pricking sensations were observed at the time of injection, but these symptoms disappeared without any treatment within a few minutes. No other adverse reactions nor abnormal laboratory test findings were observed. In conclusion, roxatidine acetate hydrochloride administered intravenously 1 hour prior to anesthesia is thought to be useful to prevent acid aspiration pneumonitis.

  18. 偏头痛采用尼美舒利分散片联合盐酸氟桂利嗪治疗的临床分析%Migraine Clinical Use of Nimesulide Dispersible Joint hydrochloride Flunar-izine Treatment

    Institute of Scientific and Technical Information of China (English)

    杨正运

    2016-01-01

    treatment, observation group nimesulide dispersible tablets Flunarizine Hydrochloride Combined treatment; headache disorders observed and compared two groups of patients before and after the severity, seizure frequency, duration, accompa-nying symptoms changes, as well as the clinical efficacy of migraine affect life situation score. Results After treatment, clinical observation group total effective rate was 79.31%, 49.55% in the control group, the observation group was signifi-cantly higher (P<0.05); After treatment syndrome before treatment than waiting score significantly improved (P<0.05), the observation group headache condition after treatment severity score was (1.54 ± 0.74), seizure frequency score was (1.01 ± 0.85), duration score was (1.25 ± 0.85) and associated symptoms related syndromes score was (0.85 ± 0.36), in the control group the severity of pain and illness rates as (4.47 ± 1.30), seizure frequency score was (2.79 ± 1.54), duration score was 2.03 ± 0.96) and associated symptoms related syndromes score was (0.85 ± 0.36), observation group item syndrome scores were significantly lower than the control group(P<0.05) the difference was statistically significant.. Conclusion The combi-nation of clinical treatment of migraine nimesulide dispersible tablets and flunarizine hydrochloride therapy can significantly refreshing to clinical patient outcomes, while significantly delay the symptoms of migraine can reduce disease recurrence in patients after treatment while improving prognosis.

  19. Thermoanalytical Investigation of Terazosin Hydrochloride

    Directory of Open Access Journals (Sweden)

    Mona Mohamed Abdel-Moety

    2013-02-01

    Full Text Available Purpose: Thermal analysis (TGA, DTG and DTA and differential scanning calorimetry (DSC have been used to study the thermal behavior of terazosin hydrochloride (TER. Methods: Thermogravimetric analysis (TGA/DTG, differential thermal analysis (DTA and differential scanning calorimetry (DSC were used to determine the thermal behavior and purity of the used drug. Thermodynamic parameters such as activation energy (E*, enthalpy (H*, entropy (S* and Gibbs free energy change of the decomposition (G* were calculated using different kinetic models. Results: The purity of the used drug was determined by differential scanning calorimetry (99.97% and specialized official method (99.85% indicating to satisfactory values of the degree of purity. Thermal analysis technique gave satisfactory results to obtain quality control parameters such as melting point (273 ºC, water content (7.49% and ash content (zero in comparison to what were obtained using official method: (272 ºC, (8.0% and (0.02% for melting point, water content and ash content, respectively. Conclusion: Thermal analysis justifies its application in quality control of pharmaceutical compounds due to its simplicity, sensitivity and low operational costs. DSC data indicated that the degree of purity of terazosin hydrochloride is similar to that found by official method.

  20. 认知行为治疗联合盐酸度洛西汀肠溶胶囊治疗广泛性焦虑障碍的对照研究%A comparative study of cognitive behavior therapy combined with Duloxetine Hydrochloride Enteric Capsule in the treatment of generalized anxiety disorder

    Institute of Scientific and Technical Information of China (English)

    买力开木·阿布都克里木; 米尔孜合买提·买买提明; 刘红萍; 西尔扎提·买买提

    2015-01-01

    目的:研究认知行为疗法联合盐酸度洛西汀肠溶胶囊治疗广泛性焦虑障碍的疗效。方法选取广泛性焦虑障碍患者64例随机分为两组。对照组采用盐酸度洛西汀肠溶胶囊治疗,实验组在对照组基础上采用认知行为疗法治疗。结果实验组患者临床效果更显著,不良反应发生率比对照组更低,P<0.05。结论采用认知行为疗法联合盐酸度洛西丁肠溶胶囊治疗广泛性焦虑障碍患者,可以有效提高临床疗效,降低不良反应发生率。%To study the effect of cognitive behavior therapy combined with Duloxetine Hydrochloride Enteric Capsule in the treatment of generalized anxiety disorder objective. Methods:64 patients with generalized anxiety disorder were randomly divided into two groups. The control group using Duloxetine Hydrochloride Enteric Capsule treatment, the experimental group in the control group based on the use of cognitive behavioral therapy. Results:The clinical effect was more obvious in the experimental group, the incidence rate of adverse reactions was lower than that of the control group, P<0.05. Conclusion:The cognitive behavior therapy combined hydrochloride duloxetine enteric coated capsule treatment in patients with generalized anxiety disorder can effectively improve the clinical efficacy, reduce the incidence of adverse reactions.

  1. 盐酸氨基葡萄糖和依托芬那酯凝胶治疗膝骨关节炎的临床研究%Clinical Study on Glucosamine Hydrochloride and Etofenamate Gel in the Treatment of Knee Osteoarthritis

    Institute of Scientific and Technical Information of China (English)

    卢卫忠; 胡志芬; 周杰

    2012-01-01

    目的 临床观察盐酸氨基葡萄糖和依托芬那酯凝胶治疗膝骨关节炎(KOA)的疗效.方法 2010年6月-2012年2月,将354例KOA患者随机分为盐酸氨基葡萄糖组(A组)、依托芬那酯凝胶组(B组)和盐酸氨基葡萄糖+依托芬那酯凝胶组(C组).A组为口服盐酸氨基葡萄糖,750mg/次,2次/d,疗程6周;B组为依托芬那酯凝胶外用,2次/d,6周为1个疗程;C组为在A组的基础上同时加用B组的方法.结果 C组在改善行走疼痛、夜间静息痛、晨僵方面优于A、B组,A组优于B组,差异有统计学意义(P<0.05).总有效率A组为79.65%,B组67.28%,C组89.38%,差异有统计学意义(P<0.05).出现不良反应A组3例,B组3例,C组4例,均较轻微,无严重不良事件发生.结论 盐酸氨基葡萄糖和依托芬那酯凝胶治疗KOA均安全、有效,联合应用时,疗效进一步增强.%Objective To observe the clinical effects of glucosamine hydrochloride and etofenamate gel in the treatment of knee osteoarthritis (KOA). Methods From June 2010 to February 2012, 354 patients suffering from knee osteoarthritis in the Department of Orthopedics of our hospital were randomly divided into three groups: the glucosamine hydrochloride group (group A), etofenamate gel group (group B), and the co-treatment with glucosamine hydrochloride and etofenamate gel group (group C). Patients in group A took oral glucosamine hydrochloride at 750 mg once for 2 times every day for 6 weeks. Patients in group B used etofenamate gel 2 times every day for 6 weeks as a treatment course. Patients in group C were co-treated with the methods of group A and B. Results For the symptomatic improvement of joint pain at walking, rest pain at night, and morning stiffness after treatment, group C was better than group A and B, and group A was better than group B, and both differences were significant (P < 0.05). The total effective rate was 79.65%, 67.28% and 89.38% respectively in group A, B and C, and there was

  2. Acute Psychotic Symptoms due to Benzydamine Hydrochloride Abuse with Alcohol

    Directory of Open Access Journals (Sweden)

    Yahya Ayhan Acar

    2014-01-01

    Full Text Available Benzydamine hydrochloride is a locally acting nonsteroidal anti-inflammatory drug. Benzydamine hydrochloride overdose can cause stimulation of central nervous system, hallucinations, and psychosis. We presented a young man with psychotic symptoms due to benzydamine hydrochloride abuse. He received a total dose of 1000 mg benzydamine hydrochloride with alcohol for its hallucinative effects. Misuse of benzydamine hydrochloride must be considered in differential diagnosis of first-episode psychosis and physicians should consider possibility of abuse in prescribing.

  3. Spectrophotometric simultaneous estimation of ranitidine hydrochloride and ondansetron hydrochloride from tablet formulation

    Directory of Open Access Journals (Sweden)

    Pillai S

    2007-01-01

    Full Text Available Three simple, accurate, economical and reproducible UV spectrophotometric methods for simultaneous estimation of two component drug mixture of ranitidine hydrochloride and ondansetron hydrochloride from combined tablet dosage form have been developed. First developed method involves formation and solving of simultaneous equations at 267.2 nm and 314.4 nm. Second method was developed making use of first order derivative spectroscopy using 340.8 nm and 276.0 nm as zero crossing points for estimation of ranitidine hydrochloride and ondansetron hydrochloride respectively. Third method is based on two wavelength calculation, wavelengths selected for estimation of ranitidine hydrochloride were 266.1 nm and 301.8 nm and for ondansetron hydrochloride 305.7 nm and 319.2 nm. The results of analysis have been validated statistically and by recovery studies.

  4. Clinical Evaluation of Oral Valaciclovir Hydrochloride Tablets Pidotimod Tablets in the Treatment of Recurrent Genital Herpes%评价口服盐酸伐昔洛韦片联合匹多莫德片治疗复发性生殖器疱疹的临床疗效

    Institute of Scientific and Technical Information of China (English)

    何志光; 姜乐

    2016-01-01

    目的:分析和评价口服盐酸伐昔洛韦片联合口服匹多莫德片治疗复发性生殖器疱疹的临床疗效。方法选取我院2014年4月~2015年10月收治的82例复发性生殖器疱疹患者,按照抽签法将患者平均分为观察组和对照组,观察组患者接受盐酸伐昔洛韦片联合匹多莫德片的治疗,对照组患者仅接受盐酸伐昔洛韦片的治疗,比较临床疗效。结果观察组患者治疗有效率更高(97.56%vs.80.49%,χ2=4.493,P<0.05)、复发率更低(43.90%vs.70.73%,P<0.05)。结论盐酸伐昔洛韦片联合匹多莫德片口服治疗复发性生殖器疱疹临床疗效显著,可提高患者治疗有效率、降低复发率。%Objective Clinical analysis and evaluation of oral and oral valaciclovir hydrochloride tablets pidotimod tablets in the treatment of recurrent genital herpes.MethodsIn our hospital from April 2014 to October 2015, 82 cases of recurrence of genital herpes patients, according to the draw method patients were divided into the observation group and the control group and observation group patients were treated with valaciclovir hydrochloride valacyclovir tablets combined with pidotimod tablets, patients in the control group only received the treatment of valaciclovir hydrochloride tablets, compared the clinical efifcacy.Results The effective rate of the observation group was higher (97.56%vs. 80.49%, χ2=4.493,P< 0.05), and the recurrence rate was lower (43.90%vs. 70.73%,P < 0.05). Conclusion Hydrochloride cutting valacyclovir tablets combined with pidotimod tablets oral in the treatment of recurrent genital herpes clinical curative effect significantly, improve treatment efficiency and reduce the recurrence rate.

  5. Clinical Observation of Glucosamine Hydrochloride Combined with Chondroitin Sulfate in the Treatment of Lumbar Facet Joint Osteoarthritis%盐酸氨基葡萄糖联合硫酸软骨素治疗腰椎小关节骨关节炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    杨勇; 陈旭; 昝中学; 苟金平; 吴万军; 古其军

    2012-01-01

    目的 观察比较盐酸氨基葡萄糖单独使用及与硫酸软骨素联合使用治疗腰椎小关节骨关节炎(LFOA)的临床疗效.方法 2009年1月-2011年1月,将80例LFOA患者随机分成两组,A组口服盐酸氨基葡萄糖,B组口服盐酸氨基葡萄糖和硫酸软骨素两种药物,6周为1个疗程,间断治疗4个疗程.分别比较用药前与用药后3、6周及5、8、11个月时的日本骨科协会(JOA)评分、晨僵和压痛程度变化.结果 治疗后,两组的JOA评分在各观察时点均增加,与治疗前比较差异有统计学意义(P<0.05).组间行JOA评分治疗改善率的比较,在各观察时点差异均有统计学意义(P<0.05),B组JOA评分改善率优于A组.治疗3周后,两组晨僵和压痛评分均降低,与本组治疗前比较差异有统计学意义(P<0.05);组间比较,差异亦有统计学意义(P<0.05),B组晨僵和压痛程度均低于A组.第6周,第5、8、11个月,两组组间比较晨僵和压痛程度差异均无统计学意义(P>0.05),但各疗程结束后两组晨僵和压痛程度均呈持续降低趋势.结论 单独应用盐酸氨基葡萄糖及盐酸氨基葡萄糖与硫酸软骨素的联合应用治疗LFOA疗效确切,联合用药优于单独应用盐酸氨基葡萄糖.%Objective To observe the clinical effect of glucosamine hydrochloride or glucosamine hydrochloride and chondroitin sulfate in combination on the treatment of lumbar facet joint osteoarthritis (LFOA). Methods From January 2009 to January 2011, 80 patients with LFOA were randomly divided into 2 groups: group A with medication of glucosamine hydrochloride and group B with medication of glucosamine hydrochloride and chondroitin sulfate in combination. Each group was treated for 4 courses and 6 weeks for every course. The clinical effect from the change of score of the items observed at each point of each group was compared with its' pretreatment, and the clinical effect was compared in the two groups at the same point

  6. [Efficacy and safety analysis of ivabradine hydrochloride treatment of Chinese patients with chronic heart failure: subgroup analysis of Chinese patients in the SHIFT study].

    Science.gov (United States)

    Hu, D Y; Huang, D J; Yuan, Z Y; Zhao, R P; Yan, X W; Wang, M H

    2017-03-24

    Objective: To evaluate the efficacy and safety of ivabradine for the treatment of Chinese patients with chronic heart failure based on the Chinese subgroup data of the systolic heart failure treatment with the I(f) inhibitor ivabradine trial (SHIFT). Method: A total of 6 558 stable outpatients who presented symptoms of heart failure, with a left ventricular ejection fraction (LVEF) ≤35%, sinus rhythms with a heart rate ≥70 bpm participated in the randomized, double-blind, placebo-controlled, international multicenter clinical study.The subset of Chinese patients with heart rate ≥75 bpm was enrolled in the post-hoc subgroup analyses.Patients were randomly allocated by computer-generated assignment through a telephone interactive voice response system to ivabradine group (starting dose 5 mg bid, which was then uptitrated to the maximum 7.5 mg bid) or matched placebo group.The clinical baseline characteristics of participants were obtained and analyzed.The primary outcome endpoint was a composite endpoint of cardiovascular death or hospitalization resulting from worsening HF.The primary safety endpoint included total incidence of adverse events during the study, bradycardia, and adverse visual reaction (phosphenes). Results: A total of 49 Chinese centers enrolled a total of 225 patients with chronic heart failure, of whom, 106 patients were randomized to the ivabradine group and the other 119 patients to the placebo group, and the mean follow-up time was (15.6±5.1) months.By the end of the study, mean heart rate (71.0 bpm vs. 80.3 bpm, Pivabradine group than in the placebo group.The total number of adverse events (129 events, 49.6% PY) in the ivabradine group was lower than that in the placebo group (203 events, 50.8% PY). In the ivabradine group and the placebo group, there were respectively 2 patients (1.9%) and 0 patients experienced bradycardia, 3 patients (2.9%) and 1 patient (0.8%) experienced adverse visual reaction (phosphenes). Conclusions: Ivabradine

  7. Extended-Release Guaifenesin/Pseudoephedrine Hydrochloride for Symptom Relief in Support of a Wait-and-See Approach for the Treatment of Acute Upper Respiratory Tract Infections: A Randomized, Double-Blind, Placebo-Controlled Study.

    Science.gov (United States)

    Septimus, Edward J; Albrecht, Helmut H; Solomon, Gail; Shea, Tim; Guenin, Eric P

    2017-01-01

    Despite the well-known fact that antibiotics (AB) are not effective against viruses, many patients ask for - and all too often doctors provide - AB for treating URTIs. Over-prescribing of AB is one of the key causes for the development of bacterial resistance, which the U.S. Centers for Disease Control and Prevention (CDC) calls "one of the world's most pressing public health problems". In addition to the CDC initiated "Get Smart About Antibiotics" campaign, focused on educating doctors the public about the importance of appropriate AB use, other programs tackling this problem include the development of new treatment paradigms. Data published at the Oregon Health & Science University demonstrated that a 'wait-and-see' approach, without an AB prescription for the treatment of acute childhood ear infections, was as quick, safe, and effective in resolving the infections as an AB prescription (Spiro DM, Tay KY, Arnold DH, Dziura JD, Baker MD, Shapiro ED. Wait-and-See Prescription for the Treatment of Acute Otitis Media. JAMA 2006; 296:1235-1241). To try and reduce inappropriate prescribing practices, a wait and see or delayed approach requires patients to return for a prescription if their symptoms persist or worsen. The aim of this study was to determine whether treatment with Mucinex D (Reckitt Benckiser LLC, Parsippany, New Jersey) lowers the use of antibiotics in the treatment of URTIs when compared with placebo. Patients aged 18 to 75 years with symptoms of acute URTIs were randomized to 1200 mg guaifenesin/120 mg pseudoephedrine hydrochloride extended-release, bilayer tablets or matching placebo for 7 consecutive days. Eligible patients met physician's criteria for antibiotic therapy but were considered suitable for a wait and see approach (withholding antibiotics for ≥48 hours). Patients recorded symptom ratings via an interactive voice response system. One thousand one hundred eighty-nine patients enrolled; data are presented for the modified intent

  8. Spectrophotometric determination of diphenhydramine hydrochloride using dipicrylamine.

    Science.gov (United States)

    Shamsa, F A; Maghssoudi, R H

    1976-05-01

    A spectrophotometric procedure for the determination of diphenhydramine hydrochloride based on the reaction with dipicrylamine was developed. A yellow complex forms and is easily extractable by chloroform at pH 5. The mole ratio of diphenydramine hydrochloride to dipicrylamine in the complex is 1:3. The absorbance of the complex obeys Beer's law over the concentration range of 3-10 mug of diphenhydramine hydrochloride per ml of chloroform. This procedure can be carried out in the presence of other compounds without interference.

  9. Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride

    Directory of Open Access Journals (Sweden)

    Y. Ankamma Chowdary

    2014-01-01

    Full Text Available In the treatment of type 2 diabetes mellitus a continuous therapy is required which is a more complex one. As in these patients there may be a defect in both insulin secretion and insulin action exists. Hence, the treatment depends on the pathophysiology and the disease state. In the present study, multilayered tablets of pioglitazone hydrochloride 15 mg and metformin hydrochloride 500 mg were prepared in an attempt for combination therapy for the treatment of type 2 diabetes mellitus. Pioglitazone HCl was formulated as immediate release layer to show immediate action by direct compression method using combination of superdisintegrants, namely, crospovidone and avicel PH 102. Crospovidone at 20% concentration showed good drug release profile at 2 hrs. Metformin HCl was formulated as controlled release layer to prolong the drug action by incorporating hydrophilic polymers such as HPMC K4M by direct compression method and guar gum by wet granulation method in order to sustain the drug release from the tablets and maintain its integrity so as to provide a suitable formulation. The multilayered tablets were prepared after carrying out the optimization of immediate release layer and were evaluated for various precompression and postcompression parameters. Formulation F13 showed 99.97% of pioglitazone release at 2 hrs in 0.1 N HCl and metformin showed 98.81% drug release at 10 hrs of dissolution in 6.8 pH phosphate buffer. The developed formulation is equivalent to innovator product in view of in vitro drug release profile. The results of all these evaluation tests are within the standards. The procedure followed for the formulation of these tablets was found to be reproducible and all the formulations were stable after accelerated stability studies. Hence, multilayered tablets of pioglitazone HCl and metformin HCl can be a better alternative way to conventional dosage forms.

  10. Mucoadhesive microspheres of propranolol hydrochloride for nasal delivery

    Directory of Open Access Journals (Sweden)

    Dandagi P

    2007-01-01

    Full Text Available Gelatin A microspheres of propranolol hydrochloride for intranasal systemic delivery were developed with the aim to avoid first pass metabolism, to improve the patient compliance, to use an alternative therapy to conventional dosage form, to achieve controlled blood level profiles, and to improve the therapeutic efficacy of propranolol hydrochloride in the treatment of various cardiovascular disorders and as a prophylactic for migraine. Gelatin A microspheres were prepared by emulsion crosslinking method using glutaradehyde as a crosslinking agent. Gelatin and chitosan were used as polymer and co polymer respectively. All the prepared microspheres were evaluated for physical characteristics, such as particle size, incorporation efficiency, swelling index, in vitro bioadhesion using rat jejunum and in vitro drug release in pH 6.6 phosphate buffer. Average particle size of microspheres was found to be in the size range 1-50 mm. Increase in drug and polymer concentration in the formulation increased incorporation efficiency. All the microsphers showed good bioadhesive properties and swelling indices and good sustained release of drug. The data indicates that propranolol hydrochloride release followed Higuchi′s matrix and Peppa′s model. Stability studies showed stability of formulation at all the conditions to which they were subjected.

  11. 交泰丸联合盐酸多奈哌齐治疗血管性痴呆45例临床研究%Clinical research on Jiaotai Pill combined with Donepezil Hydrochloride in the treatment of 45 patients with vascular dementia

    Institute of Scientific and Technical Information of China (English)

    胡玉英; 胡跃强; 张青萍; 梁妮; 刘永辉

    2013-01-01

    目的 观察交泰丸联合盐酸多奈哌齐治疗血管性痴呆(vascular dementia,VD)的临床疗效.方法 90例VD患者按随机数字表法随机分为两组,治疗组 45例采用交泰丸0.02 g/(kg·d),2次/d,早晚饭后口服,同时予盐酸多奈哌齐5 mg每晚临睡前口服,共治疗4周.对照组45例采用盐酸多奈哌齐5 mg每晚临睡前口服,共治疗4周.观察治疗4周后的临床疗效,以及治疗4周后评价简易精神状况检查量表(MMSE)、日常生活能力(ADL)的变化.结果 治疗组治疗后的显效率和总有效率均明显高于对照组(P < 0.05);并且治疗组治疗后MMSE和ADL评分均明显高于对照组(P < 0.05).结论 交泰丸联合盐酸多奈哌齐治疗VD疗效显著,优于单独使用盐酸多奈哌齐.%Objective To observe the clinical efficacy on jiaotai Pill combined with Donepezil Hydrochloride in the treatment of vascular dementia (VD). Methods 90 patients with VD were randomly divided into treatment group and control group. 45 patients in the treatment group were given Jiaotai Pill 0.02 g/(kg?d), 2 time a day after breakfast and supper, meanwhile they were given 5 mg Donepezil Hydrochloride orally at bedtime every night. 45 patients in the control group were given 5 mg Donepezil Hydrochloride orally at. bedtime every night. Patients of two groups were treated for 4 weeks. The clinical efficacy after 4 weeks treatment and the changes of MMSE and ADL before and after 4 weeks treatment were observed. Results After treatment, the treatment group was better than the control group obviously in the aspect of apparent rate and the total effective rate (P < 0.05). The MMSE and ADL scores of treatment group were better than that of control group obviously (P < 0.05). Conclusion The Jiaotai Pill combined with Donepezil Hydrochloride in the treatment of vascular dementia (VD) is very effective in clinical efficacy. The clinical efficacy is better than using Donepezil Hydrochloride alone.

  12. [A prospective multicenter randomized controlled clinical study on the efficacy and safety of Guaifenesin compound pseudoephedrine hydrochloride oral solution].

    Science.gov (United States)

    Lu, Quan

    2010-03-01

    To evaluate efficacy and safety of Guaifenesin compound pseudoephedrine hydrochloride oral solution for the treatment of cough, expectoration, nasal congestion and runny nose in children. This was a prospective multicenter randomized single-blind, parallel-controlled clinical study. A total of 10 centers participated in this study, the actual number of cases in line with the program was 412, of whom 205 cases in trial group were treated with Guaifenesin compound pseudoephedrine hydrochloride oral solution, and 207 cases in control group with ambroxol hydrochloride oral solution, treatment of both groups persisted for 7 days. The improvement rate of each single symptom and the combined symptoms and the overall effective rate were compared between the two groups. The adverse drug reactions and compliance were assessed as well. The treatment of both groups showed efficacy. Except sputum stickiness, the improvement of all symptoms in trial group was superior to that in the control group on the 3rd day after treatment (P Guaifenesin compound pseudoephedrine hydrochloride oral solution was 82.9% and the overall efficacy rate was 89.3%. Guaifenesin compound Pseudoephedrine hydrochloride oral solution had higher compliance and its adverse event rate was merely 0.92%. Guaifenesin compound pseudoephedrine hydrochloride oral solution showed significant efficacy and safety in children for treatment of cough, expectoration, nasal congestion and runny nose caused by common cold or acute tracheobronchitis.

  13. Clinical studies of severe cancer pain oxycodone hydrochloride sustained-release tablets in the treatment of%盐酸羟考酮缓释片治疗中重度癌痛的临床研究

    Institute of Scientific and Technical Information of China (English)

    李成彪; 王玉珮; 齐雪花; 罗艳琴

    2015-01-01

    ObjectiveTo observe the oral oxycodone hydrochloride sustained-release tablets were administered the back-ground of moderate to severe cancer pain titration, titration analysis of efficacy and safety in order to reasonably extended release formulation of oxycodone titration improve moderate to severe cancer pain pain, improve the quality of life of patients. Methods in April 2011 to June 2013 to 116 cases with moderate to severe cancer pain patients in this study, should be completed im-mediately BPI pain scale outbreak. Taking oxycodone hydrochloride sustained-release tablets 10mg one hour after pain assess-ment, such as pain can not be controlled, preclude the use of immediate-release morphine titrated until pain control. Record achieve pain control titration number of cycles needed, while also recording the life quality improvement and evaluation of drug safety before and after treatment. Selected results of 116 cases of cancer pain, moderate pain 104 cases, 12 patients with severe cancer pain, male 80 cases, female 36 cases, in the course of treatment, pain control to compare different sex ratio, chi-square value = 0.006, P=0.938, no significant difference difference; compare pain control rate of the different nature of pain, the chi-square value = 2.377, P=0.305 comparing the difference was not significant difference varying degrees of pain Comparison of pain control rate, chi-square value = 20.135, P=0.000, there was a significant difference comparing the difference; compare different ages pain control rate, the chi-square value = 0.041, P=0.839, comparing the difference was not significant differ-ence. Comparison of different intensity of pain titration period, t=-3.683, P=0.13, the degree of pain pain control cycle impact;the groups before and after comparison of complications, chi-square =33.294, P=0.000, patient into After the set of concurrent symptoms of nausea, vomiting accounted for 6.90%, accounting for 70.69 percent of constipation, urinary

  14. Stability Indicating HPLC Method for Simultaneous Quantification of Trihexyphenidyl Hydrochloride, Trifluoperazine Hydrochloride and Chlorpromazine Hydrochloride from Tablet Formulation

    Directory of Open Access Journals (Sweden)

    P. Shetti

    2010-01-01

    Full Text Available A new, simple, precise, rapid, selective and stability indicating reversed-phase high performance liquid chromatographic (HPLC method has been developed and validated for simultaneous quantification of trihexyphenidyl hydrochloride, trifluoperazine hydrochloride and chlorpromazine hydrochloride from combined tablet formulation. The method is based on reverse-phase using C-18 (250×4.6 mm, 5 μm particle size column. The separation is achieved using isocratic elution by methanol and ammonium acetate buffer (1% w/v, pH 6.5 in the ratio of 85:15 v/v, pumped at flow rate 1.0 mL/min and UV detection at 215 nm. The column is maintained at 30 °C through out the analysis. This method gives baseline resolution. The total run time is 15 min. Stability indicating capability is established buy forced degradation experiment. The method is validated for specificity, accuracy, precision and linearity as per International conference of harmonisation (ICH. The method is accurate and linear for quantification of trihexyphenidyl hydrochloride, trifluoperazine hydrochloride and Chlorpromazine hydrochloride between 5 - 15 μg/mL, 12.5- 37.5 μg/mL and 62.5 - 187.5 μg/mL respectively.

  15. Indirect Electrochemical Oxidation of 4-Amino-dimethyl-aniline Hydrochloride

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The indirect electrochemical oxidation of 4-amino-dimethyl-aniline hydrochloride containing wastewater generated from vanillin production is presented. Experiments were conducted at a constant current density of 30 mA/cm2 via a Ti/Ru-Ti-Sn ternary oxide coated anode and an undivided reactor. During the various stages of the electrolysis, parameters such as the values of chemical oxygen demand (COD) and total organic carbon (TOC) were determined in order to evaluate the feasibility of the electrochemical treatment. The energy consumption and the current efficiency during the electrolysis were calculated. The present study proves the effectiveness of the electrochemical treatment for wastewater resulted from vanillin production.

  16. A Novel Synthesis of Difloxacin Hydrochloride

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Difloxacin hydrochloride, one of aryl-fluoro quinolone antibiotic, has been synthesized in seven steps from 2, 4-dichloro-5-fluoroacetophenone via oxalylation, ethoxymethylenation,amination, cyclization, hydrolysis, decarbonylation and N-methylpiperazination. Additional four new intermediates are produced.

  17. A novel asymmetric synthesis of cinacalcet hydrochloride

    OpenAIRE

    Arava, Veera R; Laxminarasimhulu Gorentla; Pramod K. Dubey

    2012-01-01

    A novel route to asymmetric synthesis of cinacalcet hydrochloride by the application of (R)-tert-butanesulfinamide and regioselective N-alkylation of the naphthyl ethyl sulfinamide intermediate is described.

  18. A novel asymmetric synthesis of cinacalcet hydrochloride

    Directory of Open Access Journals (Sweden)

    Veera R. Arava

    2012-08-01

    Full Text Available A novel route to asymmetric synthesis of cinacalcet hydrochloride by the application of (R-tert-butanesulfinamide and regioselective N-alkylation of the naphthyl ethyl sulfinamide intermediate is described.

  19. A novel asymmetric synthesis of cinacalcet hydrochloride

    Science.gov (United States)

    Gorentla, Laxminarasimhulu; Dubey, Pramod K

    2012-01-01

    Summary A novel route to asymmetric synthesis of cinacalcet hydrochloride by the application of (R)-tert-butanesulfinamide and regioselective N-alkylation of the naphthyl ethyl sulfinamide intermediate is described. PMID:23019473

  20. 丙戊酸镁缓释片联合盐酸多奈哌齐胶囊治疗老年痴呆精神行为障碍的疗效观察%The Curative Effect of Magnesium Combined with Donepezil Hydrochloride Capsules in the Treatment of Patients with Behavioral and Psychiatric Disorders in Senile Dementia

    Institute of Scientific and Technical Information of China (English)

    孙平; 曲春晖; 王立钢

    2016-01-01

    目的:对老年痴呆(AD)患者联合应用丙戊酸镁缓释片与盐酸多奈哌齐胶囊的临床疗效进行观察。方法将我院收治的70例老年痴呆患者随机分为对照组与观察组,给予对照组单纯盐酸多奈哌齐胶囊治疗,观察组患者则在此基础上加用丙戊酸镁缓释片。对两组患者的治疗效果进行对比与评价。结果经过为期16周的治疗,观察组患者的MMSE评分显著高于对照组(P<0.05);观察组患者的ADAS和Blessed-Roth评分显著高于对照组(P<0.05)。结论通过对老年痴呆患者联合应用丙戊酸镁缓释片与盐a酸多奈哌齐胶囊进行治疗,可显著改善患者的精神行为障碍,促进其生活自理能力的提高,值得临床推广应用。%Objective To investigate the clinical of magnesium combined with donepezil hydrochloride capsules in the treatment of patients with behavioral and psychiatric disorders in senile dementia(AD).Methods 70 cases of senile dementiawith mental disorderwere divided into two groups, control group and observation group. The control group was treated with donepezil hydrochloride capsules, the observation group was treated with magnesium combined with donepezil hydrochloride capsules.The effect of the two groups were compared and evaluated. Results After 16 weeks of treatment, the MMSE score of the observation group was significantly higher than that of control group (P<0.05). The ADAS score and Blessed-Roth score of the observation group was significantly higher than that of control group (P<0.05).Conclusion Using magnesium combined with donepezil hydrochloride capsules to treat thepatients of behavioral and psychiatric disorders can significantly improve the patient’s mental and behavioral disorders, promote their self-care ability increase, it is worthy of clinical application.

  1. Comparative Study on Efficacy and Safety of Compound Glucosamine Hydrochloride Capsules and Tablets in Treatment of Osteoarthritis%复方盐酸氨基葡萄糖胶囊与片剂治疗骨关节炎疗效及安全性的对比研究

    Institute of Scientific and Technical Information of China (English)

    孙永红; 罗东方; 詹志军

    2016-01-01

    目的:探讨不同剂型的复方盐酸氨基葡萄糖治疗骨关节炎的疗效及安全性。方法:选取2012年7月—2016年6月湖北省谷城县人民医院收治的骨关节炎患者306例作为研究对象,采用区组随机化分组方法分为胶囊组、片剂组及安慰剂组3组,每组各102例。胶囊组患者给予复方盐酸氨基葡萄糖胶囊3粒,片剂组患者给予复方盐酸氨基葡萄糖片剂3片,安慰剂组患者给予复方盐酸氨基葡萄糖胶囊1粒、片剂1粒、安慰剂1粒,1日3次。观察不同用药方案的安全性与临床疗效。结果:胶囊组、片剂组患者的关节功能与视觉模拟评分法评分均明显低于安慰剂组,差异均有统计学意义( P<0.05);胶囊组与片剂组的总有效率均显著高于安慰剂组,差异均有统计学意义( P<0.05);3组患者不良反应发生率的差异无统计学意义( P>0.05)。结论:采用复方盐酸氨基葡萄糖胶囊剂或片剂治疗骨关节炎,均疗效显著,且安全可靠。%OBJECTIVE:To probe into the efficacy and safety of different formulations of compound Glucosamine hydrochloride capsules and tablets in treatment of osteoarthritis .METHODS:306 patients with osteoarthritis admitted into Hubei Province Gucheng County People's Hospital from Jul .2012 to Jun.2016 were selected to be divided into capsule group , tablet group and placebo group via the random number table , with 102 cases in each .The capsule group were given three compound Glucosamine hydrochloride capsules , the tablet group were treated with three Glucosamine hydrochloride tablets , and the placebo group received one Glucosamine hydrochloride capsule , one Glucosamine hydrochloride tablet , three times a day .The clinical efficacy and safety of different therapeutic regimen were observed .RESULTS: The joint function recovery and visual analogue scale score of capsule group and tablet group were significantly lower than that

  2. 氨咖敏甲麻胶囊治疗普通感冒的多中心随机双盲平行对照临床研究%Multicenter randomized double blind parallel clinical trial of compound methylephedrine hydrochloride capsules in the treatment of common cold

    Institute of Scientific and Technical Information of China (English)

    曲文秀; 刘宏博; 赵立; 孙继梅

    2011-01-01

    Objective To study the efficacy and safety of compound methylephedrine hydrochloride capsules in the treatment of common cold.Methods A randomized double blinded parallel controlled trial was conducted. Individuals were randomly divided trial (112 cases) or control (109 cases) groups, compound methylephedrine hydrochloride capsules (150 mg per capsule) or paracetamol pseudoephe-drine hydrochloride and chlorphcnamine maleate capsules (250 mg per capsule), 2 kind of capsuls was taken orally three times daily for 3 ~5 days. Results The clinical efficacy rate of compound methylephedrine hydrochloride capsules and paracetamol pseudoephe-drine hydrochloride and chlorphcnamine maleate capsules group was 88.07% and 86.61% respectively (the results of PP analysis, P > 0.05 ), and the clinical cure rate was 78.90% and 71.43% respectively. The cure rate of nasal discharge was 88.99% and 90.18%. The cure rate of sneeze was 90.83% and 92.86%. The cure rate of rhinocleisis was 85.32% and 81.25%. The cure rate of pharyngodynia was 88.99% and 83.04%. The cure rate of limbs ache was 96.33% and 95.54%. The cure rate of headache was 95.41% and 95.54% . The incidence of adverse drug reaction was 3.51% and 4.42% for trial and control groups. All the results of the two groups had no significant difference (P > 0.05) . Conclusion Compound methylephedrine hydrochloride capsule was effective and well tolerated in the treatment of common cold.%目的 研究氨咖敏甲麻胶囊治疗普通感冒的疗效和安全性.方法 用多中心随机双盲平行对照试验设计,将患者随机分为试验组(109例)与对照组(112例),2组分别口服氨咖敏甲麻胶囊与氨酚伪麻那敏胶囊,每次2粒(分别为150 mg×2,250 nag×2),1日3次,疗程3~5天.结果 2组临床控制率(78.90%,71.43%)及有效率(88.07%,86.61%)比较均无统计学差异(P>0.05).2组对发热的治愈率均为100%;对流涕的治愈率分别为88.99%,90.18%;对

  3. Management of attention-deficit hyperactivity disorder in adults: focus on methylphenidate hydrochloride

    Directory of Open Access Journals (Sweden)

    Rajasree Nair

    2009-08-01

    Full Text Available Rajasree Nair, Shannon B MossBaylor Family Medicine Residency at Garland, Garland, Texas, USAAbstract: Attention-deficit hyperactivity disorder (ADHD is one of the most common psychiatric disorders in young adults and causes significant psychosocial impairment and economic burden to society. Because of the paucity of long-term evidence and lack of national guidelines for diagnosis and management of adult ADHD, most of the data are based on experience derived from management of childhood ADHD. This article reviews the current evidence for the diagnosis and management of adult ADHD with special emphasis on the role of methylphenidate hydrochloride preparations in its treatment. Methylphenidate hydrochloride, a stimulant that acts through the dopaminergic and adrenergic pathways, has shown more than 75% efficacy in controlling the symptoms of adult ADHD. Although concern for diversion of the drug exists, recent data have shown benefits in preventing substance use disorders in patients with adult ADHD.Keywords: adult ADHD, treatment, stimulants, methylphenidate hydrochloride

  4. A randomized, crossover design study of sevelamer carbonate powder and sevelamer hydrochloride tablets in chronic kidney disease patients on haemodialysis

    OpenAIRE

    Fan, Stanley; Ross, Calum; Mitra, Sandip; Kalra, Philip; Heaton, Jeremy; Hunter, John; Plone, Melissa; Pritchard, Nick

    2009-01-01

    Background. Sevelamer carbonate is an improved, buffered form of sevelamer hydrochloride developed for the treatment of hyperphosphataemia in CKD patients. Sevelamer carbonate formulated as a powder for oral suspension presents a novel, patient-friendly alternative to tablet phosphate binders. This study compared the safety and efficacy of sevelamer carbonate powder with sevelamer hydrochloride tablets in CKD patients on haemodialysis. Methods. This was a multi-centre, open-label, randomized,...

  5. SYNTHESIS OF 2, 6-DIAMINO-3-PHENYLAZOPYRIDINE-1-OXIDE AND ITS HYDRO-CHLORIDE

    Directory of Open Access Journals (Sweden)

    Ganesh Babu Talagadadeevi, Ramakrishna Muvva, Bangar Reddy Vancha and Madhusudana Rao Jampani*

    2013-11-01

    Full Text Available The compound 2, 6-diamino-3-phenylazopyridine hydrochloride salt is a genito-urinary antiseptic drug under the trade name Pyridinium. This study is directed towards the occurrence of an oxidation reaction to convert the tertiary amine present in 2, 6-diamino-3-phenylazopyridine hydrochloride to form an N-oxide derivative as an impurity in the process for its preparation. This was done by the independent synthesis of 2, 6-diamino-3-phenylazopyridine-1-oxide hydrochloride salt by two independent routes. The presence of three amine functions in the molecule required first to protect the primary amine groups by derivatisation so that oxidation occurs exclusively at the tertiary amino group of the pyridine ring. 2, 6-diamino-3-phenylazopyridine was acetylated to get 2, 6-diacetamido-3-phenylazopyridine whose structure was confirmed from 1H NMR and mass spectral data. The oxidation of diacetyl derivative with peracetic acid resulted not only in the N-oxide formation but also in the cleavage of one of the acetamido group to give 2(6-acetamido-6(2amino-3-phenylazopyridine-1-oxide. The alkaline hydrolysis of the N-oxide form gave 2, 6-diamino-3-phenylazopyridine-1-oxide which on treatment with hydrochloric acid gave 2, 6-diamino-3-phenylazopyridine-1-oxide hydrochloride. In yet another route the N-oxide was prepared by the coupling reaction between benzene diazonium chloride and 2, 6-diaminopyridine-1-oxide in aqueous hydrochloric acid medium. This reaction resulted in the formation of 2, 6-diamino-3- phenylazopyridine-1-oxide hydrochloride as an insoluble salt. The structure of the N-oxide was confirmed from 1H NMR and mass spectral data. A co-injection HPLC analysis showed the complete absence of 2, 6-diamino-3-phenylazopyridine-1-oxide hydrochloride in 2, 6-diamino-3-phenylazopyridine hydrochloride in its manufacturing process.

  6. 联合应用牙龈炎冲洗器和盐酸米诺环素治疗冠周炎的效果探讨%Investigation of effect by gingivitis flusher combined with minocycline hydrochloride in the treatment ;of pericoronitis

    Institute of Scientific and Technical Information of China (English)

    陈跃英

    2015-01-01

    Objective To investigate the effect of gingivitis flusher combined with minocycline hydrochloride in the treatment of pericoronitis. Methods A total of 92 patients with pericoronitis were divided by different treatment measures into control group with 32 cases and combined treatment group with 60 cases. The control group received conventional treatment, and the combined treatment group received gingivitis flusher combined with minocycline hydrochloride for treatment. Gingival index and pain relieve time were observed in the two groups for comparison of effective rate in treating pericoronitis patients. Results The combined treatment group had lower gingival index and pain relieve time than the control group, and its effective rate was higher as 93.3%than 65.6%of the control group. Their difference had statistical significance (P<0.05). Conclusion Combination of gingivitis flusher and minocycline hydrochloride can remarkably improve clinical symptoms in treating pericoronitis with good effect. This method is worthy of clinical promotion and application.%目的:探讨联合应用牙龈炎冲洗器和盐酸米诺环素治疗冠周炎的效果。方法92例冠周炎患者,依据治疗措施不同分为对照组32例和联合治疗组60例。对照组给予常规治疗,联合治疗组联合应用牙龈炎冲洗器和盐酸米诺环素治疗,观察两组患者牙龈指数和疼痛缓解时间,比较两组冠周炎患者临床治疗有效率。结果联合治疗组患者牙龈指数和疼痛缓解时间均低于对照组,联合治疗组临床治疗有效率93.3%优于对照组65.6%,差异均有统计学意义(P<0.05)。结论联合应用牙龈炎冲洗器和盐酸米诺环素治疗冠周炎患者临床症状改善明显,效果良好,值得临床推广应用。

  7. Curative effect of bromhexine hydrochloride and glucose injection in the treatment of senile chronic bronchitis during the attack stage%盐酸溴己新葡萄糖注射液治疗老年慢性支气管炎发作期疗效观察

    Institute of Scientific and Technical Information of China (English)

    胡志润

    2016-01-01

    Objective:To observe the curative effect of bromhexine hydrochloride and glucose injection in the treatment of senile chronic bronchitis during the attack stage.Methods:96 cases of elderly patients with chronic bronchitis during the attack stage were divided into two groups randomly,with 48 cases in each group.The control group was given conventional comprehensive treatment,and the treatment group was given bromhexine hydrochloride and glucose injection treatment based on the control group. The clinical curative effect of the two groups was compared.Results:The total effective rate of the treatment group was 93.7%,and the total effective rate of the control group was 70.83%.The total effective rate of the treatment group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Bromhexine hydrochloride and glucose injection in the treatment of senile chronic bronchitis during the attack stage had significant clinical curative effect.%目的:观察盐酸溴己新葡萄糖注射液治疗老年慢性支气管炎发作期疗效。方法:收治老年慢性支气管炎发作期患者96例,随机分成两组,每组48例。对照组给予常规综合治疗,治疗组在对照组基础上给予盐酸溴己新葡萄糖注射液治疗,比较两组临床疗效。结果:治疗组总有效率93.7%,对照组总有效率70.83%。治疗组总有效率明显高于对照组,差异具有统计学意义(P<0.05)。结论:盐酸溴己新葡萄糖注射液治疗老年慢性支气管炎发作期临床疗效显著。

  8. 78 FR 34108 - Determination That SUBOXONE (Buprenorphine Hydrochloride and Naloxone Hydrochloride) Sublingual...

    Science.gov (United States)

    2013-06-06

    ... HUMAN SERVICES Food and Drug Administration Determination That SUBOXONE (Buprenorphine Hydrochloride and... (buprenorphine hydrochloride (HCl) and naloxone HCl) sublingual tablets, 2 milligrams (mg)/0.5 mg and 8 mg/2 mg... to approve abbreviated new drug applications (ANDAs) for buprenorphine HCl and naloxone...

  9. Naloxone hydrochloride in treatment of opioid or alcohol poisoning patients%盐酸纳洛酮在阿片类或乙醇类中毒患者中的临床应用及效果观察

    Institute of Scientific and Technical Information of China (English)

    付帮林; 匡冬梅

    2015-01-01

    Objective To explore and analyze the clinical application and effect of naloxone hydrochloride on opioid or alcohol poisoning patients.Methods The clinical data of 84 patients with acute alcoholism admitted into our hospital from December, 2012 to December, 2014 was retrospectively analyzed. According to random number table, they were divided into a control group 1 and an experimental group 1, 42 cases for each group. The alcohol poisoning symptoms disappearing time, time taking effect, and effectiveness of these two groups were compared. The clinical data of 60 patients with opioid poisoning caused by overusing morphine admitted into our hospital from December, 2012 to December, 2014 was retrospectively analyzed.According to random number table, they were divided into a control group 2 and an experimental group 2.The morphine poisoning symptoms disappearing time, time taking effect, and effectiveness of these two groups were compared.Results The time taking effect was (40.29±18.22) min in the control group 1 and was (21.33±9.25) min in the experimental group 1, with a statistical difference (t = 3.98,P < 0.05); the symptoms disappearing time was (80.29±28.32) min in the control group 1 and was(40.33±14.23) min in the experimental group 1, with a statistical difference (t = 3.54,P < 0.05). The the total effective rate was 85.7% in the control group 1 and was 100.0% in the experimental group 1, with a statistical difference (χ2 = 5.49,P < 0.05). The total effective rate was 66.7% in the control group 2 and was 100.0% in the experimental group 2, with a statistical difference (χ2= 4.69,P < 0.05).ConclusionsNaloxone hydrochloride in the treatment of acute alcoholism or opioid drug poisoning can effectively control poisoning symptoms and shorten the time taking effect and is helpful for the recovery of body function.%目的:探究与分析盐酸纳洛酮在阿片类或乙醇类中毒患者中的临床应用及效果。方法选取我院2012年12月至2014年12

  10. 盐酸羟考酮控释片治疗老年癌痛体会%Treatment for cancerous pain in the elderly with Oxy-Codone hydrochloride controlled-release tablets.

    Institute of Scientific and Technical Information of China (English)

    刘彦芳; 刘端祺; 李红英; 张侠

    2010-01-01

    Objective To evaluate effectiveness and side effects, as well as its safety, of Oxy-Codone hydrochloride controlled-release tablets (Oxycontin) for the elderly patients with moderate to severe cancerous pain. Methods From March 2005 to February 2009,106 elderly patients ( aged more than 60 years) suffered from moderate to severe cancerous pain were treated with Oxycontin,at initial dose of 10 mg/12 h. For the patients using making them pain-free or pain relieved mostly. Every patient was treated for 4 weeks at least. Severity of pain,sleeping status, appetite, fatigue, mental status, daily life, scores of understanding and cooperation, and side effects were .observed.Results The minimal effective dose of Oxycontin was 10 mg/d for the elderly patients with cancerous pain. Twenty-three patients (21.7%) were treated with it at dose of ≥200 mg/d,30 patients (28. 2% )at dose of 100 - 180 mg/d,and 53 patients (50. 0% ) at dose of 10 -90 mg/d. Pain was relieved in 97. 16% of the patients after treatment, with common side effects of constipation, nausea, vomiting;and drug treatment was needed for 24. 53% (26/106) of the patients with more common constipation. Conclusions Oxycontin is effective,tolerable,less side-effects for the elderly patients with moderate to severe cancerous pain, and can improve their quality of life.%目的 观察盐酸羟考酮控释片(商品名:奥施康定),治疗老年恶性肿瘤患者中、重度疼痛的临床效果及不良反应,明确该药在治疗老年癌痛中的有效性及安全性.方法 2005年3月至2009年2月中、重度疼痛老年恶性肿瘤患者(年龄≥60岁)106例,给予盐酸羟考酮控释片镇痛治疗,初始剂量10 mg/12 h,正在用吗啡类镇痛药者,按照口服吗啡1/2剂量换算,根据疼痛情况调整剂量,直至患者无痛或基本无痛,每位患者至少治疗4周以上.同时进行疼痛强度、睡眠、食欲、疲乏、精神状态、日常生活、理解配合程度评

  11. Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance

    Directory of Open Access Journals (Sweden)

    Zhi-Gang Cheng

    2014-01-01

    Full Text Available Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm × 4.6 mm, 5 µm. All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR. The identification of these impurities should be useful for quality control in the manufacture of barnidipine.

  12. Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance.

    Science.gov (United States)

    Cheng, Zhi-Gang; Dai, Xu-Yong; Li, Li-Wei; Wan, Qiong; Ma, Xiang; Xiang, Guang-Ya

    2014-01-21

    Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm×4.6 mm, 5 µm). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR). The identification of these impurities should be useful for quality control in the manufacture of barnidipine.

  13. The effects of clomipramine hydrochloride in cats with psychogenic alopecia: a prospective study.

    Science.gov (United States)

    Mertens, Petra A; Torres, Sheila; Jessen, Carl

    2006-01-01

    A double-blind, placebo-controlled clinical trial was conducted to determine the efficacy of clomipramine hydrochloride in cats with psychogenic alopecia. Twenty-five cats were randomly assigned to receive clomipramine hydrochloride (0.5 mg/kg orally q 24 hours) or placebo for 56 days. Eleven cats in each group completed the trial. The results of this study showed that clomipramine hydrochloride failed to demonstrate significant changes in the number of grooming bouts, hair regrowth, and the area of alopecia in cats with psychogenic alopecia when compared to a placebo. It was uncertain whether these results reflected a lack of drug efficacy, insufficient treatment duration, or an insufficient number of cases enrolled.

  14. Compound list: fluoxetine hydrochloride [Open TG-GATEs

    Lifescience Database Archive (English)

    Full Text Available fluoxetine hydrochloride FLX 00158 ftp://ftp.biosciencedbc.jp/archive/open-tggates/...LATEST/Human/in_vitro/fluoxetine_hydrochloride.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/o...pen-tggates/LATEST/Rat/in_vivo/Liver/Single/fluoxetine_hydrochloride.Rat.in_vivo.Liver.Single.zip ftp://ftp....biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/fluoxetine_hydrochloride.Rat.in_vivo.Liver.Repeat.zip ...

  15. Second generation lipid nanoparticles (NLC) as an oral drug carrier for delivery of lercanidipine hydrochloride.

    Science.gov (United States)

    Ranpise, Nisharani S; Korabu, Swati S; Ghodake, Vinod N

    2014-04-01

    Lercanidipine hydrochloride is a calcium channel blocker used in the treatment of hypertension. It is a poor water soluble drug with absolute bioavailability of 10%. The aim of this study was to design lercanidipine hydrochloride-loaded nanostructured lipid carriers to investigate whether the bioavailability of the same can be improved by oral delivery. Lercanidipine hydrochloride nanostructured lipid carriers were prepared by the method of solvent evaporation at a high temperature and solidification by freeze drying. The nanostructured lipid carriers were evaluated for particle size analysis, zeta potential, entrapment efficiency, in vitro drug diffusion, ex vivo permeation studies and pharmacodynamic study. The resultant nanostructured lipid carriers had a mean size of 214.97 nm and a zeta potential of -31.6 ± 1.5 mV. More than 70% lercanidipine hydrochloride was entrapped in the NLCs. The SEM studies indicated the formation of type 2 nanostructured lipid carriers. The in vitro release studies demonstrated 19.36% release in acidic buffer pH 1.2 indicating that the drug entrapped in the nanostructured lipid carriers remains entrapped at acidic pH. The ex vivo studies indicated that the drug release was enhanced from 10% to 60.54% at blood pH in 24h. The in vivo pharmacodynamic study showed that NLCs released lercanidipine hydrochloride in a controlled manner for a prolonged period of time as compared to plain drug. These results clearly indicate that nanostructured lipid carriers are a potential controlled release formulation for lercanidipine hydrochloride and may be a promising drug delivery system for the treatment of hypertension. Copyright © 2013 Elsevier B.V. All rights reserved.

  16. 21 CFR 182.1047 - Glutamic acid hydrochloride.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Glutamic acid hydrochloride. 182.1047 Section 182.1047 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... Food Substances § 182.1047 Glutamic acid hydrochloride. (a) Product. Glutamic acid hydrochloride....

  17. Curative effect observation of glucosamine hydrochloride capsules compound with ozone injection in the treatment of osteoarthritis of the knee%盐酸氨基葡萄糖胶囊复合臭氧注射治疗膝关节炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    段宏涛; 赵欣; 郑伟; 张晓波

    2014-01-01

    Objective:To explore the curative effect of glucosamine hydrochloride capsules compound with ozone injection in the treatment of osteoarthritis of the knee.Methods:200 cases with degenerative arthritis of the knee were selected from March 2009 to March 2012.They were treated with oral glucosamine capsules,2 times/day,750 mg/time,with the knee joint injection of ozone,1 time/week,for 4 weeks as 1 course.After 3 courses of treatment,we evaluated the effect of treatment.Results:In 200 cases,162 cases(81%) were excellent;34 cases(17%) were good;4 cases(2%) were poor;he total efficiency was 98%.Conclusion:The curative effect of glucosamine hydrochloride capsules compound with ozone injection in the treatment of osteoarthritis of the knee is significant.%目的:评价氨基葡萄糖胶囊复合臭氧注射治疗膝关节炎的临床效果。方法:2009年3月-2012年3月收治退行性膝关节炎患者200例,采用口服氨基葡萄糖胶囊治疗,2次/d,750 mg/次,配合臭氧膝关节注射,1次/周,4周1个疗程。经过3个疗程治疗后,评价治疗效果。结果:200例患者中,治疗效果优162例(81%),良34例(17%),差4例(2%),总有效率98%。结论:盐酸氨基葡萄糖胶囊配合臭氧注射治疗膝关节炎疗效肯定。

  18. Quality of life in patients with Irritable Bowel Syndrome (IBS), assessed using the IBS-Quality of Life (IBS-QOL) measure after 4 and 8 weeks of treatment with mebeverine hydrochloride or pinaverium bromide: results of an international prospective observational cohort study in Poland, Egypt, Mexico and China.

    Science.gov (United States)

    Hou, Xiaohua; Chen, Shengliang; Zhang, Yali; Sha, Weihong; Yu, Xiaofeng; Elsawah, Hesham; Afifi, Afifi Fahmy; El-Khayat, Hisham Raafat; Nouh, Alaa; Hassan, Mohamed Fathalla; Fatah, Ayman Abdel; Rucker Joerg, Isabel; Sánchez Núñez, Juan Manuel; Osthoff Rueda, Rodolfo; Jurkowska, Grazyna; Walczak, Michal; Malecka-Panas, Ewa; Linke, Krzysztof; Hartleb, Marek; Janssen-van Solingen, Gwendolyn

    2014-11-01

    Irritable Bowel Syndrome (IBS) has a substantial impact on health-related quality of life (HR-QoL) but high-quality data pre- and post-treatment using the IBS-Quality of Life (IBS-QOL) measure are limited. The objective of this study was to evaluate the changes from baseline of the IBS-QOL scores, symptom scores and health economic data in IBS patients, after 4 and 8 weeks of treatment with mebeverine hydrochloride or pinaverium bromide. This was a prospective observational cohort study in patients with IBS, diagnosed using the Rome III criteria in four countries (Poland, Egypt, Mexico and China). A total of 607 patients were enrolled. At baseline, the IBS-QOL total scores were 52.0 in Poland, 48.9 in Egypt, 51.9 in Mexico, 76.4 in China and 56.4 overall. Increases in IBS-QOL total score were statistically significant at Weeks 4 and 8 overall and in each country (overall: 11.8 at Week 4, 24.3 at Week 8; p < 0.001). Improvements were shown in all IBS-QOL subscales and scores. Symptoms and health economic outcomes were improved. Furthermore, the favourable safety profile of these treatments was confirmed in this study. This study demonstrated that IBS patients have a substantially reduced HR-QoL and that treatment with mebeverine hydrochloride or pinaverium bromide improved HR-QoL.

  19. Effects of Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection on the prevention and treatment of acute radiation-induced pneumonitis in rats%参芎注射液防治胸部肿瘤放疗导致放射性肺损伤的实验研究

    Institute of Scientific and Technical Information of China (English)

    周晓红; 唐力; 齐亚灵

    2014-01-01

    Objective:To evaluate whether Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection has posi-tive effects on the prevention and treatment of radiation-induced lung injury. The basic function and mechanism of Salviae Miltiorrhi-zae Liguspyragine Hydrochloride and Glucose Injection were also investigated. Methods:A total of 70 adult male rats weighing about 200 g were selected and divided into seven groups. These groups were as follows:1) normal control group (N):rats were injected with 1 ml of normal saline per day;2) single medicine treatment group (D):rats were administered with 1 ml of Salviae Miltiorrhizae Ligus-pyragine Hydrochloride and Glucose Injection per day;3) single irradiation group (Z):rats were exposed to 20 Gy single whole-chest ir-radiation and injected with 1 ml of normal saline per day;4) irradiation with 10 Gy and medicine treatment group (Z10):rats were ex-posed to 10 Gy single whole-chest irradiation and administered with 1 ml of Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection per day; 5) irradiation with 15 Gy and medicine treatment group (Z15): rats were exposed to 15 Gy single whole-chest irradiation and administered with 1 ml of Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection per day;6) irradiation with 20 Gy and medicine treatment group (Z20a):rats were exposed to 20 Gy single whole-chest irradiation for four weeks, and administered with 1 ml of Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection per day;and 7) irradia-tion with 20 Gy and medicine treatment group (Z20b):rats were exposed to 20 Gy single whole-chest irradiation and administered with 1 ml of Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection per day. Two rats were selected and sacrificed at the end of two, four, six, eight, and ten weeks of irradiation. Samples of blood and lung tissues in rats were obtained. Results:In the group with single irradiation, the tumor

  20. 盐酸氨溴索辅佐阿奇霉素治疗儿童肺炎支原体肺炎疗效评价%Curative effect evaluation of ambroxol hydrochloride assisting azithromycin in the treatment of children with myco-plasma pneumoniae pneumonia

    Institute of Scientific and Technical Information of China (English)

    孙庆霞

    2016-01-01

    目的:探讨盐酸氨溴索联合阿奇霉素治疗儿童肺炎支原体肺炎的临床疗效。方法:收治肺炎支原体肺炎患儿100例,随机分为两组,每组50例。对照组给予阿奇霉素治疗及对症支持治疗,试验组在对照组基础上给予盐酸氨溴索治疗,比较两组临床疗效。结果:试验组总有效率98.00%,对照组总有效率60.00%。试验组疗效优于对照组,差异具有统计学意义(P<0.05)。结论:盐酸氨溴索联合阿奇霉素治疗儿童肺炎支原体肺炎的临床疗效显著,能促进患儿肺功能的恢复。%Objective:To investigate the clinical curative effect of ambroxol hydrochloride combined with azithromycin in the treatment of children with mycoplasma pneumoniae pneumonia.Methods:100 cases of children with mycoplasma pneumoniae pneumonia were divided into two groups randomly,with 50 cases in each group.Patients in the control group were given azithromycin and symptomatic and supportive treatment.Patients in the experiment group were given ambroxol hydrochloride on the basis of the control group.The clinical curative effect of two groups was compared.Results:The total effective rate of the experiment group was 98.00%,and the total effective rate of the control group was 60.00%.The curative effect of the experiment group was better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Ambroxol hydrochloride combined with azithromycin in the treatment of children with mycoplasma pneumoniae pneumonia had significant clinical curative effect and could promote the recovery of pulmonary function in children.

  1. A comparative study of the clinical efficacy of ambroxol hydrochloride combined with hydrocortisone sodium succinate in the treatment of infantile bronchitis%盐酸氨溴索与氢化可的松琥珀酸钠治疗毛细支气管炎的临床疗效对比研究

    Institute of Scientific and Technical Information of China (English)

    许焕胜

    2016-01-01

    Objective To investigate the ambroxol hydrochloride combined with hydrocortisone sodium succinate in treatment of children with bronchiolitis.Methods 120 children with bronchitis in our hospital from January 2014 to September 2015 were selected, divided into a control group and an observation group according to the random number table method. The two groups were treated with conventional bronchitis treatment and nursing, the control group was treated with hydrocortisone sodium succinate treatment, the observation group with ambroxol hydrochloride in the treatment of choice. After treatment, the clinical effect and the clinical symptoms and time of bronchitis symptoms disappeared between two groups were compared.Results Patients in the observation group after the atomization inhalation of ambroxol hydrochloride, the clinical effective rate was 75%, which was significantly higher than that in the control group, the bronchitis curative effect rate was 40%, the difference was statistically significant (P<0.05). Observation group in children with bronchiolitis related clinical symptoms or symptoms such as shortness of breath, hold wheezing, wet rales, cough disappeared time were significantly shorter than that in the control group, the difference was statistically significant (P<0.05).Conclusion Inhalation of ambroxol hydrochloride in the treatment of infantile bronchitis has better clinical efficacy, can effectively shorten the bronchitis associated symptoms and signs, safe and effective, worthy of clinical application.%目的:探讨盐酸氨溴索与氢化可的松琥珀酸钠在治疗毛细支气管炎的临床疗效。方法选取我院2014年1月~2015年9月收治的毛细支气管炎患者共120例,按照随机数字表法分为对照组与观察组,两组患者均接受常规支气管炎治疗与护理,对照组患儿接受氢化可的松琥珀酸钠治疗,观察组患儿选择盐酸氨溴索治疗。治疗结束后比较两组患者治疗毛细支

  2. 盐酸氨基葡萄糖联合塞来昔布对膝关节骨性关节炎的临床疗效观察%Clinical Study of Glucosamine Hydrochloride Combined with Celecoxib on the Treatment of Knee Osteoarthritis

    Institute of Scientific and Technical Information of China (English)

    李伟; 赵育红; 武长江; 刘光宇; 刘涛; 郭晓东

    2015-01-01

    Objective:To observe the clinical effects of glucosamine hydrochloride combined with celecoxib on the treatment of knee osteoarthritis.Methods:60 patients with osteoarthritis who were treated in om hospital from June 2012 to March 2014 were selected and divided into the observation group and the control group according to different treatment methods.The patients in the observation group were treated by glucosamine hydrochloride combined with celecoxib,while the patients in the control group were treated by glucosamine hydrochloride only.Then the adverse reactions and Lequesne scores of patients were observed and compared between the two groups before and after the treatment.Results:There was no statistically significant difference about the adverse reactions in the two groups (P>0.05).The Lequesne scores of patients in the two groups were lower than before,and the treatment group was lower than that of the control group with statistically significant differences (P<0.05).Conclusions:The clinical effect of glucosamine hydrochloride combined with celecoxib is better than either of them on the treatment of knee osteoarthritis.%目的:观察盐酸氨基葡萄糖联合塞来昔布治疗膝关节骨性关节炎的效果及对不同程度关节炎Lequesne评分的影响,为关节炎的临床治疗提供参考.方法:选取2012年6月至2014年3月我院收治的膝关节骨性关节炎患者60例,根据治疗方法不同,将所选患者分为观察组和对照组,每组30例.对照组患者给予盐酸氨基葡萄糖单药治疗,观察组患者给予盐酸氨基葡萄糖和塞来昔布联合治疗.观察两种治疗方案的不良反应发生率,比较两组患者治疗前后的Lequesne评分.结果:对照组患者不良反应的发生率为26.67%,观察组为23.33%,差异无统计学意义(P>0.05).两组患者治疗后的Lequesne评分均低于治疗前,且观察组患者Lequesne评分显著低于对照组,差异具有统计学意义(P<0.05).观察组不同

  3. Chitosan coated vancomycin hydrochloride liposomes: Characterizations and evaluation.

    Science.gov (United States)

    Yang, Zhenlei; Liu, Junli; Gao, Jinhua; Chen, Shilei; Huang, Guihua

    2015-11-10

    The present work evaluated the feasibility of chitosan coated liposomes (c-Lips) for the intravenous delivery of vancomycin hydrochloride (VANH), a water-soluble antibiotic for the treatment of gram-positive bacterial infections like osteomyelitis, arthritis, endocarditis, pneumonia, etc. The objective of this research was to develop a suitable drug delivery system in vivo which could improve therapeutic efficacy and decrease side effects especially nephrotoxicity. Firstly, the vancomycin hydrochloride liposomes (VANH-Lips) were prepared by modified reverse phase evaporation method, then the chitosan wrapped vancomycin hydrochloride liposomes (c-VANH-Lips) nanosuspension was formulated by the method of electrostatic deposition. Based on the optimized results of single-factor screening experiment, the c-VANH-Lips were found to be relatively uniform in size (220.40 ± 3.56 nm) with a narrow polydispersity index (PI) (0.21 ± 0.03) and a positive zeta potential (25.7 ± 1.12 mV). The average drug entrapment efficiency (EE) and drug loading (DL) were 32.65 ± 0.59% and 2.18 ± 0.04%, respectively. The in vitro release profile of c-VANH-Lips possessed a sustained release Characterization and the release behavior was in accordance with the Weibull equation. Hemolysis experiments showed that its intravenous injection had preliminary safety. In vivo, after intravenous injection to mice, c-VANH-Lips showed a longer retention time and higher AUC values compared with the VANH injection (VANH-Inj) and VANH-Lips. In addition, biodistribution results clearly demonstrated that c-VANH-Lips preferentially decreased the drug distribution in kidney of mice after intravenous injection. These results revealed that injectable c-VANH-Lips may serve as a promising carrier for VANH to increase therapeutic efficacy on gram-positive bacterial infections and reduce nephrotoxicity, which provides significantly clinical value for long-term use of VANH.

  4. Multicomposite ultrathin capsules for sustained ocular delivery of ciprofloxacin hydrochloride.

    Science.gov (United States)

    Bhadra, Dipankar; Gupta, Girish; Bhadra, Sulekha; Umamaheshwari, R B; Jain, Narendra

    2004-07-16

    The present work is intended to develop a sustained bioadhesive drug delivery system for delivery of Ciprofloxacin Hydrochloride in Cul-de-Sac for sustained and effective antimicrobial chemotherapy. For this, ultrathin multicomposite capsular systems were selected. Multicomposite ultrathin capsules are molecular assemblies of tailored architecture having layer-by-layer adsorption of oppositely charged macromolecules onto colloidal particles. In the present study colloidal calcium phosphate core and gluateraldehyde fixed RBCs were used as core on which alginate (-vely charged) and polyallylamine hydrochloride (+vely charged) polyelectrolyte coating was deposited alternatively upto 10th layer. The coating in each subsequent layer was determined by changes in zeta potential. Ciprofloxacin hydrochloride was loaded in the capsules by incubation with the capsules suspended in phosphate buffer saline pH 7.4. The cores of the capsules were then removed by treatment with 0.1N HCl for calcium phosphate core and by sodium hypochlorite for RBC cored capsules. The hollow ciprofloxacin HCl loaded capsules were the evaluated in-vitro for pattern of layer-by-layer drug loading, drug release, stability at various temperatures and ionic concentrations and corneal retention. The core removal process was found to have minimal effects on drug loading in capsules. The drug loading was found to be higher for RBC cored hollow capsules and hence release rate was lower as compared to calcium cored hollow capsules. Draize test for corneal irritancy proved that the capsules were not irritating. The capsules were found to deliver the ciprofloxacin in cul-de-sac of rabbit's eyes for prolonged period. Based on corneal retention studies and tear drug concentration, the capsules can be considered for suitable and safe use for sustained ocular delivery of drugs.

  5. Intestinal Anisakiasis Treated Successfully with Prednisolone and Olopatadine Hydrochloride

    Directory of Open Access Journals (Sweden)

    Hideki Toyoda

    2016-02-01

    Full Text Available The clinical characteristic of gastrointestinal anisakiasis is severe abdominal pain after eating raw fish. Intestinal anisakiasis is more uncommon than gastric anisakiasis. Most patients with intestinal anisakiasis need hospitalization because anisakiasis can cause intestinal obstruction, ileus, peritonitis or intestinal perforation. We report a case of intestinal anisakiasis. A 43-year-old woman presented with symptoms of intermittent abdominal pain 2 days after eating raw fish. Her brother had eaten the same food and had been suffering from gastric anisakiasis. Abdominal ultrasonography in this patient showed localized jejunal wall thickening with dilated lumen of proximal jejunum and ascites. According to the clinical course and examinations, she was diagnosed with intestinal anisakiasis. Administration of prednisolone 5 mg/day and olopatadine hydrochloride 10 mg/day improved her symptoms quickly without hospitalization. Prednisolone was administered for 10 days, and olopatadine hydrochloride was administered for a total of 6 weeks according to ultrasonographic findings. Six months after the treatment, the abdominal ultrasonography demonstrated normal findings. This case demonstrates that ultrasonography was quite useful for the diagnosis and surveillance of intestinal anisakiasis. Furthermore, treatment with corticosteroid and an antiallergic agent could be an option for patients with intestinal anisakiasis.

  6. Effect of peritumoral injection of boanmycin hydrochloride within temperature-sensitive in situ gel using Hep-G2 hepatoma nude mice model

    Institute of Scientific and Technical Information of China (English)

    WANG Zhi-hui; DING Wei-ming; HU Xiang-dong; LI Mei; XU Hong-zhang; QIAN Lin-xue

    2012-01-01

    Background Boanmycin hydrochloride,a new antitumor agent,has a short half-life and fast clearance speed in vivo.The aim of this research was to investigate the effectiveness of peritumor injection of boanmycin hydrochloride within temperature-sensitive gel in situ using Hep-G2 hepatoma nude mice model.Methods Nude mice with human Hep-G2 tumor in right flank were randomly divided into four groups: normal saline group,in situ gel only group,boanmycin hydrochloride in situ saline group,and boanmycin hydrochloride in situ gel group,and were treated with injection of corresponding agents into peripheral tissue of the tumor.The volume of the tumor and the body weight of the mice were regularly measured,and tumor growth curve was generated.The size,internal echo,and blood flow of the tumors were observed by color Doppler ultrasonography.Histopathologic changes of the tumor after treatment were observed under both optical and transmission electron microscopy.Results The tumor growth was significantly inhibited by peritumoral therapy in boanmycin hydrochloride in situ gel group with the tumor inhibitory rate of 86.76%,The blood flow of the tumor was still seen in both normal saline group and in situ gel only group on color Doppler ultrasound.Punctate calcification and dotted blood flow were seen in boanmycin hydrochloride group; however,there was massive calcification and no blood flow in the tumor in the boanmycin hydrochloride in situ gel group.Large areas of necrosis and apoptotic cells were shown by microscopic observation in boanmycin hydrochloride in situ gel group.Conclusion Temperature-sensitive boanmycin hydrochloride in situ gel can effectively delay the release of boanmycin hydrochloride and increase its anticancer effects for liver cancer in animal model.

  7. Polycystic Ovary Syndrome Infertility Treatment with Diane-35,Metformin Hydrochloride Combined Clomiphene in 30 Cases%达英-35、盐酸二甲双胍联合克罗米芬治疗多囊卵巢综合征不孕30例

    Institute of Scientific and Technical Information of China (English)

    王笑蓉; 何文弘

    2013-01-01

    Objective To observe the polycystic ovary syndrome infertility efficacy treatment with the Diane - 35, metformin hydrochloride Combined clomiphene citrate. Methods Sixty cases of polycystic ovary syndrome patients in the department of infertility of our hospital from January 2010 to March 2012 were selected and randomly divided into group A and group B. The group A were given Diane - 35 and clomiphene,Diane - 35 even serving 21 d for a course,review of androgen (T) return to normal after 3 courses of treatment,disabled Diane-35,5 d of the next menstrual cycle taking Clomiphene Citrate Tablets,and even served 5 d,continuous use after 3 courses of no ovula-tion to be invalid, the use of up to 5 courses. The Group B were given Diane - 35, metformin hydrochloride combined treatment of clomiphene citrate, Diane - 35 and metformin hydrochloride tablets treated at the same time, 3 cycles of androgen normal control, disable Diane - 35 and metformin to continue with the former taking the next a menstrual cycle for 5 d, taking clomiphene citrate,observed 2 to 3 cycles still no ovulation,clomiphene citrate is invalid,the use of up to five courses. Results The ovulation rate and pregnancy rate of group A was significantly lower than group B,two groups of patients hormone levels change was significantly different ( P < 0. 05 ),with statistical significance. Conclusion Diane - 35, metformin hydrochloride, clomiphene three joint use by inhibition of androgen secretion, ovulation, the discharge of insulin resistance,reduce androgen levels and hypennsulinemia in women with polycystic ovary syndrome,promote and promote follicle hormone secretion,to ensure that the ovulation rate and pregnancy rate,improve the treatment of polycystic ovary syndrome.%目的 观察达英-35、盐酸二甲双胍联合克罗米芬治疗多囊卵巢综合征不孕的疗效.方法 选择2010年1月至2012年3月不孕科接收的多囊卵巢综合征患者60例,随机均分为A

  8. Comparative effects of zilpaterol hydrochloride and ractopamine hydrochloride on live performance and carcass characteristics of calf-fed Holstein steers.

    Science.gov (United States)

    Brown, T R; Sexten, A K; Lawrence, T E; Miller, M F; Thomas, C L; Yates, D A; Hutcheson, J P; Hodgen, J M; Brooks, J C

    2014-09-01

    Holstein steers (n = 2,275) were assigned to 1 of 3 treatments: 1) a control diet containing no β-agonists, 2) a diet that contained zilpaterol hydrochloride (ZH; 8.3 mg/kg [100% DM basis]) for 20 d with a 3-d withdrawal period before harvest, and 3) a diet that contained ractopamine hydrochloride (RH; 30.1 mg/kg [100% DM basis]) for 28 d before harvest. No differences (P ≥ 0.18) were detected between treatments for initial BW, BW at d 28, or DMI. Final BW, BW gain for the last 28 d, total BW gain, ADG for the last 28 d, and overall ADG were greater (P Feeding either β-agonist to calf-fed Holstein steers increased live performance through increased BW, BW gain, and ADG. Furthermore, supplementing calf-fed Holstein steers with ZH provides greater improvements in HCW, LM area, and yield grade components, with a slight decrease in quality grade when compared to calf-fed Holstein steers supplemented with RH.

  9. Analysis of Minocycline Hydrochloride Ointment in the Treatment of Patients With Chronic Severe Periodontitis%盐酸米诺环素软膏辅助治疗重度慢性牙周炎患者的疗效分析

    Institute of Scientific and Technical Information of China (English)

    仲琳; 陈青宇; 贺娜; 关敏

    2015-01-01

    Objective To investigate the clinical efficacy of minocycline hydrochloride ointment in the treatment of patients with chronic periodontitis. Methods Clinical data of 52 patients with severe chronic periodontitis admitted in our hospital from March 2014 to May 2015 were retrospectively analyzed, digital mode is divided into odd and even numbers of the control group (iodine glycerin) and study group (hydrochloric acid minocycline ointment), 26 cases in each group. Results The clinical efficacy study group than the control group. Conclusion The use of minocycline hydrochloride ointment in the treatment of chronic periodontitis can effectively improve the clinical symptoms, improve clinical effcacy.%目的:探讨盐酸米诺环素软膏辅助治疗重度慢性牙周炎患者的临床疗效。方法回顾性分析我院2014年3月~2015年5月收治的52例重度慢性牙周炎患者的临床资料,采用数字单双号的模式随机分为对照组(碘甘油)与研究组(盐酸米诺环素软膏),每组各26例。结果研究组的临床疗效优于对照组。结论采用盐酸米诺环素软膏治疗慢性牙周炎能够有效改善患者的临床症状,提升临床疗效。

  10. Clinical observation of methadone hydrochloride tablet in the treatment of moderate and severe cancer pain%盐酸美沙酮片治疗中重度癌性疼痛的临床观察

    Institute of Scientific and Technical Information of China (English)

    陈碧茵; 林丹; 李一璟

    2015-01-01

    目的:观察盐酸美沙酮片(美沙酮)治疗中重度癌性疼痛的临床效果、不良反应及生活质量改善情况。方法42例中重度癌性疼痛患者给予美沙酮镇痛治疗,初始剂量5 mg/12 h,根据疼痛情况调整剂量,直至患者无痛或基本无痛,每位患者至少治疗15 d以上。观察患者的疼痛缓解情况、生活质量评分及不良反应。结果42例患者经过个体化给药后确定最终剂量为5~70 mg,每12小时1次,绝大部分患者疼痛达到明显缓解以上,疼痛的总缓解率为90.5%,其中完全缓解11例(26.2%),明显缓解27例(64.3%),对中度疼痛的缓解率为93.8%,重度疼痛的缓解率为88.5%。治疗前中位KPS评分为50分,治疗后中位KPS评分为75分,患者的生活质量明显改善(P<0.05)。全组KPS评分9例(21.4%)明显改善,13例(31.0%)有改善,20例(47.6%)达到稳定,无评分下降病例;不良反应少且轻微。结论美沙酮治疗中重度癌性疼痛安全有效,不良反应发生率较低,能够明显提高患者的生活质量。%Objective To observe the clinical effect,adverse reaction,and improvement of patient’s living quality of methadone hydrochloride tablet (methadone) treating moderate and severe cancer pain. Methods Forty-two patients suf-fering from moderate or severe cancer pain were treated by methadone at an initial dosage of 5 mg/12 h.According to severity of pain,the dosage of methadone was adjusted until these patients didn’t feel pain or basically had no sensation of pain.The course of treatment for each participant lasted at least 15 days.At the same time,pain relief and quality of life were scored,and adverse reaction were observed. Results After 42 patients were given the individualized drug ad-ministration,the final dosage was set from 5 to 70 mg,at an interval of 12 h.After taking methadone,the vast majority of patients with pain was more than significantly alleviate,and the total alleviation

  11. 21 CFR 556.350 - Levamisole hydrochloride.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Levamisole hydrochloride. 556.350 Section 556.350 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS TOLERANCES FOR RESIDUES OF NEW ANIMAL DRUGS IN FOOD Specific Tolerances for Residues of New Animal Drugs...

  12. 21 CFR 184.1676 - Pyridoxine hydrochloride.

    Science.gov (United States)

    2010-04-01

    ... hydrochloride that is prepared by chemical synthesis. (b) The ingredient meets the specifications of the Food... chapter; meat products as defined in § 170.3(n)(29) of this chapter; milk products as defined in § 170.3(n)(31) of this chapter; plant protein products as defined in § 170.3(n)(33) of this chapter; and...

  13. 盐酸万乃洛韦、阿昔洛韦治疗带状泡疹临床疗效观察%Clinical Observation of Effectiveness of Valacicloir and Aciclovir Hydrochloride in the treatment of Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    黄捷

    2002-01-01

    目的:观察盐酸万乃洛韦(Valaciclovir Hydrochloride)与阿昔洛韦(Acyclovir,ACV)治疗带状疱疹临床疗效.方法:应用万乃洛韦口服治疗带状疱疹42例,并与ACV口服治疗带状疱疹40例相比较.结果:万乃洛韦组总有效率90.48%,ACV组总有效率67.5%,两组间疗效相比差异有显著性.结论:Valaciclovir Hydrodoride治疗带状疱疹疗效优于ACV.

  14. Minocycline hydrochloride as a soft sclerotizing agent for symptomatic simple renal and hepatic cysts.

    Science.gov (United States)

    Danza, F M; Falcione, M; Bordonaro, V; Infante, A; Paladini, A; Bonomo, L

    2017-01-01

    To present the results of our ten-year case series in simple hepatic and renal cysts sclerosis using minocycline hydrochloride as a sclerotizing agent, evaluating the effectiveness, the safety and the feasibility of this agent for percutaneous sclerotherapy for symptomatic cysts. We retrospectively evaluated our archives of patients treated (54 patients with 60 renal cysts, 21 patients with 24 hepatic cysts) for symptomatic abdominal cysts. These patients were treated with ultrasound guided drainage and subsequent minocycline hydrochloride instillation. In large or recurrent cysts, we repeated the treatment for the second time. The patients were evaluated at 6 and 12 months; some patients underwent later, additional examinations and we also reviewed these exams for any eventual long-term relapse. The percentage of sclerosis success was found to be 100% for hepatic cysts and 86% for renal cysts. We also found that minimal complications were encountered. Minocycline hydrochloride has proven to be an effective sclerotizing agent. In our cases, symptoms disappeared in 100% of patients with hepatic cysts and in 93% of patients with renal cysts. It is also a safe sclerotizing agent, as demonstrated by the few complications encountered. Percutaneous sclerosis with Minocycline hydrochloride is a very effective and promising nonsurgical treatment for patients with symptomatic simple cysts, and it can be performed without major complications.

  15. The Impact of Hydrochloride Heroin on Mental Flexibility, Abstract Reasoning, Impulsivity, and Attention

    Directory of Open Access Journals (Sweden)

    Zahra Alam Mehrjerdi

    2011-04-01

    Full Text Available Introduction: Drug addiction could lead to severe impairments in executive and neurocognitive functions but study on the impact of hydrochloride heroin on executive functions has remained in infancy in Iran. The aim of this study was to examine the relationship between addiction to hydrochloride heroin and executive functioning in several cognitive domains including mental flexibility, abstract reasoning, impulsivity, and attention. Methods: A total of 60 cases of young male addicts aged 18 to 21 were recruited from outpatient addiction clinics in Karaj city and were matched with 60 non-drug using controls. A test battery including the Wisconsin Card Sorting Test (WCST, Porteus Maze Test (PMQS, Serial Seven Subtraction Test (SSST, and Color Trails Test (CTT were administered respectively. Results: The patient group showed more problems in impulse control compared with the control group, while mental flexibility, abstract reasoning and attention were not affected. Discussion: The findings indicated that addiction to hydrochloride heroin had a negative effect on impulse control. This issue could reflect the role of impaired inhibitory control on drug-seeking behaviors and relapse. Special treatment programs must be tailored to control impulsivity among addicts to hydrochloride heroin during treatment.

  16. 盐酸氟西汀配合中成药治疗孕中期引产产妇产后抑郁的研究%The treatment of postpartum depression after induction of labour in second trimester with fluoxetine hydrochloride and Chinese traditional patent medicine

    Institute of Scientific and Technical Information of China (English)

    尹钰荣; 吴莉娜; 张淼

    2011-01-01

    目的 探讨盐酸氟西汀联合中成药治疗中孕引产产妇产后抑郁的临床疗效和不良反应.方法 将46例孕中期引产产妇产后抑郁患者随机分为研究组(氟西汀20 mg/d配合中成药组)和对照组(单用氟西汀20 mg/d组),每组各23例,共治疗6周.用汉密尔顿抑郁量表(HAMD)评定疗效,用药物不良反应量表(TESS)评定不良反应.结果 治疗6周后,研究组与对照组总有效率分别为95.6%和95.6%,两组比较差异无显著性.研究组起效快,与对照组比较,在治疗的第1周末及出现显著差异(P0.05).结论 盐酸氟西汀联合中成药治疗孕中期引产产妇产后抑郁比单用盐酸氟西汀起效快,药物副作用小.%Objective To investigate the curative effect and adverse reaction of fluoxetine hydrochloride in combination with Chinese traditional patent medicine in the treatment of postpartum depression after induction of labour in second trimester. Methods Forty - six patients with postpartum depression after induction of labour in second trimester were randomly divided into fluoxetine - Chinese traditional patent medicine treatment group ( 23 patients ) and fluoxetine treatment group ( 23 patients ), Patients in both groups were treated for 6 wks. The efficacy and the adverse effect of the treatment were evaluated with Hamilton depression rating scale ( HAMD ) and adverse drug reactions scale ( TESS ) respectively. Results after 6 wks treatment, the total effective rate in both groups was 95. 6%. Compared with fluoxetine treatment group, rapid effect was observed in fluoxetine - Chinese traditional patent medicine treatment group at wk 1 ( P 0. 05 ). Conclusion Fluoxetine hydrochloride combined with Chinese traditional patent medicine effects quickly and presents less adverse effect for the treatment of postpartum depression after induction of labour in second trimester.

  17. The Clinical Effect of Benner Pury Hydrochloride Combined with Spironolactone in the Treatment of Heart Failure in Diabetic Heart Disease%探讨盐酸贝那普利联合螺内酯治疗糖尿病心脏病心力衰竭的临床效果

    Institute of Scientific and Technical Information of China (English)

    于淋淋

    2016-01-01

    目的:探讨糖尿病心脏病心衰患者接受盐酸贝那普利和螺内酯联合治疗的效果。方法根据2012年6月~2014年2月我院的88例糖尿病心脏病心衰患者来进行研究分析,随机分成治疗组和常规组,治疗组使用盐酸贝那普利联合螺内酯治疗,常规组使用常规治疗方式,对两组的治疗效果进行对比分析。结果治疗组患者有效率比常规组高,患者左室舒张末径小于常规组,结果差异有统计学意义(P<0.05)。结论糖尿病心脏病心衰患者临床中接受盐酸贝那普利和螺内酯联合治疗的效果突出,患者的心功能改善情况良好,心脏射血分数显著提升,对心衰症状有很好的纠正效果,应该推广使用。%Objective To investigate the diabetic patients with heart failure underwent Benner Pury hydrochloride and spironolactone in the treatment effect.Methods According to our hospital in June 2012 to February 2014, 88 cases of diabetic heart disease and congestive heart failure patients to conduct research and analysis, were randomly divided into treatment group and routine treatment group, the treatment group with benazepril hydrochloride combined with spironolactone in the treatment, routine group use conventional treatment, carries out a comparative analysis of the therapeutic effect of the two groups.Results The effective rate of treatment group was higher than that of the conventional group, the left ventricular diastolic diameter of the patients was less than that of the conventional group, the results were statistically signiifcant (P<0.05).Conclusion Diabetic heart disease and congestive heart failure patients accepted highlight the effect of benazepril and spironolactone in the treatment, the patients with improvement of cardiac function in good condition, signiifcantly improve the cardiac ejection fraction, in heart failure symptoms have good correction effect, it should be popularized.

  18. 口服盐酸氨基葡萄糖和注射透明质酸钠以及两者联合治疗膝关节骨性关节炎的临床研究%A Randomized Controlled Clinical Trial of Glucosamine Hydrochloride, Hyaluronic Acid and Combined Use in the Treatment of Knee Osteoarthritis

    Institute of Scientific and Technical Information of China (English)

    姜丹生

    2012-01-01

    目的 评价口服盐酸氨基葡萄糖和注射透明质酸钠以及两者联合治疗膝关节骨性关节炎的疗效.方法 采用随机对照临床研究方法,将162例诊断为膝骨性关节炎的患者随机分为3组,口服组、注射组、联合用药组各54例,分别给予口服盐酸氨基葡萄糖480毫克/次,每天口服3次,关节内注射2毫升/次,每周1次.共治疗5周.停药后观察2周.收集3组患者治疗期间Lequesne指数评分和VAS评分,来评估治疗前后膝关节症状变化程度.结果 治疗5周后,口服组、注射组、联合用药组Lequesne总指数比治疗前均有明显下降,分别为3.3±1.6、3.1±1.3、2.8±1.3.联合用药组和其他两组差异具有统计学意义(P<0.05).VAS评分治疗5周后口服组、注射组、联合用药组分别下降为1.77±0.91、1.66±1.21、1.53±1.13.与治疗前相比均具有统计学差异(P<0.05).结论 口服盐酸氨基葡萄糖和关节内注射透明质酸钠均对膝骨性关节炎具有良好的疗效,两者联合治疗方式效果优于单独用药治疗方式.%Objective To evaluate the efficacy of glucosamine hydrochloride,hyaluronic acid and combined use of the two drugs in the treatment of patients with knee osteoarthritis. Methods Totally 162 patients suffering from knee osteoarthritis were random divided into 3 groups, and were treated with glucosamine hydrochloride, hyaluronic acid and combined of above two therapies. Patients reveived medicine 3 times daily with total 480mg/d for glucosamine hydrochloride group, intra - articular injection of hyaluronic acid one time a week with 2ml per time and two treatments combined for combined group. Lequesne index and VAS score were recorded at 1,2,3,4,5 weeks during therapy and 1,2 weeks after therapy. Results Lequesne index were obviously decreased at 5 weeks for 3 groups. It was 3.3 ±1.6、3.1 ±1.3、2.8 ±1.3 , respectively. VAS scores were 1.77 ±0.91、1.66 ±1.21、1. 53 ± 1.13 at 5 weeks for 3 groups

  19. Clinical Observation of Glucosamine Hydrochloride Combined Piroxicam Patch in the Treatment of 98 cases of Knee Osteoarthritis%盐酸氨基葡萄糖联合吡罗昔康贴片治疗膝骨关节炎98例疗效观察

    Institute of Scientific and Technical Information of China (English)

    张玉玲; 吕明

    2015-01-01

    目的 观察分析盐酸氨基葡萄糖胶囊(奥泰灵) 联合吡罗昔康贴片治疗膝骨关节炎的疗效. 方法 选取诊断为膝关节骨关节炎患者98例,随机分为治疗组和对照组,治疗组49 例用盐酸氨基葡萄糖胶囊联合吡罗昔康贴片治疗,对照组病例采用口服双氯芬酸钠胶囊治疗1 次25mg,1日3次,治疗组口服盐酸氨基葡萄糖胶囊0.75g,1日2次饭后,连续服用6周为1个疗程,治疗3个疗程,并且外用吡罗昔康贴片比较两种不同治疗方法的效果. 结果 两组患者在关节压痛、平地行走痛、静息痛、晨起关节僵硬、及行走能力上均有明显改善,治疗组明显优于对照组,统计学分析有显著性差异( P<0.05 ) ,临床治疗总有效率亦明显高于对照组. 两组治疗后1年半内复发病例比较P<0.05 ,与对照组比较具有统计学意义. 结论 盐酸氨基葡萄糖胶囊联合吡罗昔康贴片对治疗膝骨关节炎有明显作用,能有效地改善关节的功能,减轻临床症状,提高治愈率,远期疗效好,复发率低,值得推广.%OBJECTIVE To observe and analyze the treatment of knee osteoarthritis with Glucosamine hydro-chloridecapsuleandPiroxicamPatch.METHODS 98kneeosteoarthritispatientswererandomlydividedintotreat-ment group and control group .49 patients in treatment group were treated with Glucosamine hydrochloride capsule and Piroxicam Patch;other patients in control group were treated with Diclofenac Sodium Enteric-coated Tablets, 25 mg for each time , tid.Treatment group were treated with Glucosamine hydrochloride capsule ( 0.75 g ) , bid after meal,6 weeks as one treatment course ,consecutively 3 courses,and meanwhile,using Piroxicam Patch Compare the efficacy of these two different treatments .RESULTS obvious improvement in terms of joint pain ,walking pain ,rest pain,joint stiffness and walking ability for two groups of patients were observed ,while treatment group was much bet-ter than control group as shown with

  20. Sinomenine Hydrochloride Protects against Polymicrobial Sepsis via Autophagy

    Directory of Open Access Journals (Sweden)

    Yu Jiang

    2015-01-01

    Full Text Available Sepsis, a systemic inflammatory response to infection, is the major cause of death in intensive care units (ICUs. The mortality rate of sepsis remains high even though the treatment and understanding of sepsis both continue to improve. Sinomenine (SIN is a natural alkaloid extracted from Chinese medicinal plant Sinomenium acutum, and its hydrochloride salt (Sinomenine hydrochloride, SIN-HCl is widely used to treat rheumatoid arthritis (RA. However, its role in sepsis remains unclear. In the present study, we investigated the role of SIN-HCl in sepsis induced by cecal ligation and puncture (CLP in BALB/c mice and the corresponding mechanism. SIN-HCl treatment improved the survival of BALB/c mice that were subjected to CLP and reduced multiple organ dysfunction and the release of systemic inflammatory mediators. Autophagy activities were examined using Western blotting. The results showed that CLP-induced autophagy was elevated, and SIN-HCl treatment further strengthened the autophagy activity. Autophagy blocker 3-methyladenine (3-MA was used to investigate the mechanism of SIN-HCl in vitro. Autophagy activities were determined by examining the autophagosome formation, which was shown as microtubule-associated protein light chain 3 (LC3 puncta with green immunofluorescence. SIN-HCl reduced lipopolysaccharide (LPS-induced inflammatory cytokine release and increased autophagy in peritoneal macrophages (PM. 3-MA significantly decreased autophagosome formation induced by LPS and SIN-HCl. The decrease of inflammatory cytokines caused by SIN-HCl was partially aggravated by 3-MA treatment. Taken together, our results indicated that SIN-HCl could improve survival, reduce organ damage, and attenuate the release of inflammatory cytokines induced by CLP, at least in part through regulating autophagy activities.

  1. Sinomenine hydrochloride protects against polymicrobial sepsis via autophagy.

    Science.gov (United States)

    Jiang, Yu; Gao, Min; Wang, Wenmei; Lang, Yuejiao; Tong, Zhongyi; Wang, Kangkai; Zhang, Huali; Chen, Guangwen; Liu, Meidong; Yao, Yongming; Xiao, Xianzhong

    2015-01-23

    Sepsis, a systemic inflammatory response to infection, is the major cause of death in intensive care units (ICUs). The mortality rate of sepsis remains high even though the treatment and understanding of sepsis both continue to improve. Sinomenine (SIN) is a natural alkaloid extracted from Chinese medicinal plant Sinomenium acutum, and its hydrochloride salt (Sinomenine hydrochloride, SIN-HCl) is widely used to treat rheumatoid arthritis (RA). However, its role in sepsis remains unclear. In the present study, we investigated the role of SIN-HCl in sepsis induced by cecal ligation and puncture (CLP) in BALB/c mice and the corresponding mechanism. SIN-HCl treatment improved the survival of BALB/c mice that were subjected to CLP and reduced multiple organ dysfunction and the release of systemic inflammatory mediators. Autophagy activities were examined using Western blotting. The results showed that CLP-induced autophagy was elevated, and SIN-HCl treatment further strengthened the autophagy activity. Autophagy blocker 3-methyladenine (3-MA) was used to investigate the mechanism of SIN-HCl in vitro. Autophagy activities were determined by examining the autophagosome formation, which was shown as microtubule-associated protein light chain 3 (LC3) puncta with green immunofluorescence. SIN-HCl reduced lipopolysaccharide (LPS)-induced inflammatory cytokine release and increased autophagy in peritoneal macrophages (PM). 3-MA significantly decreased autophagosome formation induced by LPS and SIN-HCl. The decrease of inflammatory cytokines caused by SIN-HCl was partially aggravated by 3-MA treatment. Taken together, our results indicated that SIN-HCl could improve survival, reduce organ damage, and attenuate the release of inflammatory cytokines induced by CLP, at least in part through regulating autophagy activities.

  2. 盐酸氨溴索静脉用药协同雾化吸入治疗29例老年呼吸系统感染性疾病疗效观察%The effect of intravenous infusion of ambroxol hydrochloride collaborated with inhalation in the treatment of 29 cases of the elderly respiratory infectious disease

    Institute of Scientific and Technical Information of China (English)

    赵英

    2016-01-01

    Objective: To observe the effect of inhalation of ambroxol atomization in the treatment of the elderly respiratory infectious disease. Methods:From July 2014 to June 2015, 58 elderly cases of the respiratory infectious diseases were collected and randomly divided into a treatment group with 29 cases who were treated with ambroxol hydrochloride (intravenous infusion of 60 mg daily and inhalation of 15 mg twice a day with 15 min each). The control group with 29 cases intravenously received 60 mg of ambroxol hydrochloride daily. The two groups were treated with the conventional antibiotics and antispasmodic asthma. Results:The total effective rate of the treatment group was 86.21%(25/29), which was signiifcantly higher than 75.86%(22/29) of the control group (P<0.05). The improvement or termination time of the clinical signs such as cough and expectoration were shorter in the treatment group than in the control group. The pulmonary rales disappeared faster in the treatment group than in the control one. The duration of antibiotics was shorter in the treatment group than in the control one. Conclusion:The effect of intravenous infusion of ambroxol hydrochloride collaborated with inhalation in the treatment of the elderly respiratory infectious disease is rapid and safe, which is worthy of clinical promotion.%目的:观察盐酸氨溴索雾化吸入治疗老年呼吸系统感染性疾病的效果。方法:收集2014年7月-2015年6月年龄>80岁的老年呼吸系统感染性疾病患者58例,随机分为治疗组29例,静脉滴注盐酸氨溴索60 mg,每天1次,同时雾化吸入盐酸氨溴索15 mg,每天2次,每次15 min;对照组29例,静脉滴注盐酸氨溴索60 mg,每天1次。两组均给予常规抗生素和解痉平喘治疗,观察两组治疗效果。结果:治疗组总有效率为86.21%(25/29),显著高于对照组的75.86%(22/29,P<0.05)。临床体征咳嗽、咳痰好转或终止时间短于对照组,肺部啰

  3. Clinical observation of Reinhartdt and Sea Cucumber Capsule (RSC) combined and donepezil hydrochloride in treatment of alzheimer's disease%复方海蛇胶囊联合盐酸多奈哌齐治疗阿尔茨海默病临床观察

    Institute of Scientific and Technical Information of China (English)

    孔佳

    2012-01-01

    Objective It is to approach the efficacy and safety of Reinhartdt and Sea Cucumber Capsule ( RSC ) co-treatment of donepezil hydrochloride in alzheimer' s disease ( AD ). Methods Ninety-six patients with AD were randomly divided into RSC group ( 30 patients ), hydrochloric donepezil group ( 32 patients ) and combined treatment group ( 34 patients ). RSC group was treated with RSC by orally; hydrochloride donepezil group was treated with hydrochloric donepezil by orally; combined treatment group also oral RSC and hydrochloric donepezil; continuous medication for six-month-term. The mini-mental state examination ( MMSE ), activities of daily living scale ( ADL ), cognitive sub-scale ( ADAS - Cog ), clinical dementia rating scale ( CDR ) and side effects scale ( TESS ) assessment of the situation of three groups were observed. Results ①The MMSE scores in each group after treatment were greater than before, the ADL, ADAS - Cog, CDR score in each group after treatment were less than before treatment, there were significant different ( P 0. 05 ). Conclusion Combination use RSC and donepezil hydrochloride is safe and effective method in treatment of AD, the effect is better than a single drug, and the incidence of adverse reactions is low.%目的 探讨复方海蛇胶囊(RSC)联合盐酸多奈哌齐治疗阿尔茨海默病(AD)的有效性及安全性.方法 96例AD患者随机分为RSC组30例、盐酸多奈哌齐组32例和联合用药组34例,RSC组给予复方海蛇胶囊口服;盐酸多奈哌齐组给予盐酸多奈哌齐口服;联合用药组同时口服复方海蛇胶囊和盐酸多奈哌齐;连续用药6个月.观察3组患者治疗前后智能状态量表(MMSE)、日常生活能力量表(ADL)、认知次级量表(ADAS-Cog)、痴呆程度评定量表(CDR)以及副反应量表(TESS)评定情况.结果 治疗后各组MMSE评分均大于治疗前(P<0.05),ADL、ADAS-Cog、CDR评分均小于治疗前(P均<0.05);3组不良反应发生

  4. Nursing of ritodrine hydrochloride in treatment of placenea previa state of threatened abortion%利托君治疗胎盘前置状态先兆流产的护理

    Institute of Scientific and Technical Information of China (English)

    沈志娟

    2012-01-01

    Objective:To discuss the nursing measures of placenta previa with threatened abortion using hydrochloric acid ritodrine therapy. Methods :32 cases of placenta previa in our state threatened abortion pregnant women,ritodrine hydrochloride 100 mg join 5% glucose intravenous infusion of 500 ml,maintain the uterine contraction after the change to oral,and well before medication pursing assessment, psychological nursing care,close observation in the medication process condition changes,drug reaction,giving life,diet nursing care. Results:32 cases of vaginal bleeding after drug use in pregnant women reduced, adverse reactions-have been eased .more than 30 cases of maternal gestational age 36 -weeks extension,strengthening mucle success rate 93.75%. Conclusion:Rational use of-ritodrine hydrochloride,could reduced the placenta previa threatened abortion bleeding,prolonged pregnancy cycle,improved the success rate of fetus.%目的:探讨胎盘前置状态先兆流产使用盐酸利托君治疗时的护理措施.方法:对我院胎盘前置状态先兆流产32例孕妇,给予100 mg盐酸利托君加入5%葡萄糖500 ml静脉滴注,维持宫缩消失后改为口服,并在用药前做好护理评估、心理护理,用药过程中严密观察病情变化、用药反应,给予生活、饮食护理.结果:32例孕妇用药后阴道出血减少,不良反应得到缓解,30例孕妇延长孕龄36周以上,保胎成功率为93.75%.结论:盐酸利托君的合理使用,可以减少胎盘前置状态先兆流产的出血,延长妊娠周数,提高保胎成功率.

  5. Safety and efficacy of tramadol hydrochloride with behavioral modification in the treatment of premature ejaculation%盐酸曲马多联合行为疗法治疗早泄的安全性、有效性临床观察

    Institute of Scientific and Technical Information of China (English)

    熊国根; 吴飞华; 陈胜辉; 姚文亮

    2011-01-01

    目的:评价盐酸曲马多联合行为疗法治疗早泄的安全性、有效性.方法:按随机原则将72例早泄患者分为治疗组和对照组,治疗组(n=36)性生活前2 h口服盐酸曲马多50 mg联合行为疗法,对照组(n=36)予以单纯行为疗法,两组疗程均为8周,记录治疗前后阴道内射精潜伏期(IELT)、配偶性生活满意度评分、临床总有效率、不良反应和肝、肾功能.结果:两组治疗前后在IELT和改善配偶性交满意度评分方面有显著性差异(P0.05).结论:盐酸曲马多联合行为疗法在延长IELT及改善配偶性交满意度评分、临床总有效率和肝、肾功能方面,其安全性和有效性值得肯定.但盐酸曲马多为阿片类药物,成瘾性还有待评估,是否作为国内治疗早泄的常规治疗药物尚需进行多中心、双盲临床安全性及有效性的进一步研究.%Objective: To evaluate the efficacy and safety of tramadol hydrochloride with behavioral modification in delaying ejaculation in patients with premature ejaculation. Methods: Seventy-two potent men with premature ejaculation were equally and randomly assigned to a treatment group and control group, the former received 50 mg tramadol hydrochloride with behavioral modification approximately 2 hours before planned sexual activity, while the latter underwent behavioral therapy only, both treated for 8 weeks. Intravaginal ejaculatory latency time (IELT), intercourse satisfaction of the partners, total therapeutic effectiveness, adverse reactions,and hepatic and renal function of the patients were recorded and compared before and after the treatment. Results: Both the treatment and the control groups showed significant differences from pretreatment in the mean IELT and intercourse satisfaction domain values (P < 0.01 ). The total rate of effectiveness was 72.2% in the treatment group and 47.2% in the control. The former exhibited even more significant improvement than the latter in the mean

  6. 盐酸羟考酮缓释片治疗胃癌患者中重度癌痛的临床疗效观察%Efficacy of Oxycodone Hydrochloride Controlled Release Tablet in the Treatment of Gastric Cancer Patients with Moderate to Severe Cancer Pain

    Institute of Scientific and Technical Information of China (English)

    赵松峰; 张亚玲; 张晓; 师秀琴; 张祥; 张晓坚

    2016-01-01

    Objective To observe efficacy and toxicities of oxycodone hydrochloride controlled release tablet in the treatment of gastric cancer patients with moderate to severe cancer pain. Methods The 135 cases of gastric cancer patients with moderate to severe cancer pain were was administrated with oxycodone hydrochloride controlled release tablet. The starting dose was 10 to 20 mg every 12 h,the dose was adjusted according to pain degree. Every patients were treated for two weeks. The pain relief,quality of life and toxicities were evaluated after treatment. Re-sults For the 135 patients,the NRS score after treatment(1. 68 ± 0. 98)was lower than that before treatment (7. 22 ± 2. 13)(P ﹤ 0. 05). The cancer pain relief rate was 92. 6% . The improvement rate of quality of life was 74. 1% . The main toxicities were light degree nausea and vomiting,constipation drowsiness. Conclusion Oxyc-odone hydrochloride controlled release tablet can control cancer pain and improve quality of life in the treatment of gastric cancer patients with moderate to severe cancer pain,and has good safety.%目的:探讨盐酸羟考酮缓释片用于胃癌患者中重度癌痛的临床疗效和毒副反应。方法135例胃癌中重度癌痛患者均接受口服盐酸羟考酮缓释片控制癌痛,初始剂量10~20 mg/次,q12 h,用药过程中根据疼痛评估情况进行剂量调整,直至癌痛控制良好。2周后采取 NRS 评分法进行疼痛评分,并观察疼痛缓解情况、生活质量、药物毒副反应等。结果所有135例患者治疗后 NRS 评分为(1.68±0.98)分,明显低于治疗前的(7.22±2.13)分,差异有统计学意义(P ﹥0.05)。治疗后总疼痛缓解率为92.6%。生活质量改善率为74.1%。主要毒副反应为恶心呕吐、便秘、嗜睡等,均为轻度,未影响治疗的顺利进行。结论盐酸羟考酮缓释片用于胃癌患者能够良好控制中重度癌痛,明显改善患者的生活质量,且用药较为安全。

  7. [Antiseptics on the base of Octenidine Hydrochloride].

    Science.gov (United States)

    Malinovskií, N N; Reshetnikov, E A; Rubashnaia, I E; Mal'nikova, G N; Mitiukov, A P

    1997-01-01

    Comparative evaluation of laboratory and clinical investigation of antiseptic preparations on the base of octenidin-hydrochloride and bigluconate chlorhexidine in 537 patients was carried out. Statistically valid decrease in dissemination through the operation field and surgical wound after application of octenidin containing solutions was determined. It was established as well that these preparations were more effective fools of protection of the operation wound from its microbial contamination in comparison with antiseptic solutions widely spread to date in surgical practice.

  8. 抗抑郁药Duloxetine Hydrochloride

    Institute of Scientific and Technical Information of China (English)

    艾建国; 晋展

    2003-01-01

    @@ 日本Shionogi公司获得了Eli Lilly公司的授权,对其研制的一种对5-羟色胺(5-HT)和去甲肾上腺素(NE)的摄取有双重抑制作用的化合物Duloxetine Hydrochloride (Cymbalta(R),LY-264453,LY-248686)进行了进一步的开发.

  9. Effect of iptakalim hydrochloride on hemodynamics

    Institute of Scientific and Technical Information of China (English)

    Qing-leiZHU; HaiWANG; Wen-binXIAO

    2004-01-01

    AIM: To study the effect of iptakalim hydrochloride (Ipt) on hemodynamics. METHODS: Effect of Ipt on hemodynamics were studied in anesthetized nomotensive dogs, conscious nomotensive rats (NTR), and stroke prone spontaneously hypertensive rats (SHRsp), respectively. RESULTS: In pentobarbital anesthetized nomotensive dogs, Ipt at doses of 0.125, 0.25, 0.5,1.0, and 2.0 mg/kg iv could dose-dependently decrease blood pressure (BP), with the decrease of systolic BP equivalent

  10. Cartap hydrochloride poisoning: a case report

    OpenAIRE

    Sumesh Raj; Sheetal S.

    2014-01-01

    Cartap hydrochloride is a thiocarbamate insecticide used for control of chewing and sucking insects of all stages of development, on many crops. It is an analogue of nereistoxin. Poisoning with cartap is very rarely reported from India. We report a 46 year old man who consumed cartap with alcohol, presented with nausea & vomiting and improved with supportive measures. [Int J Res Med Sci 2014; 2(1.000): 360-361

  11. 盐酸吡格列酮治疗单用胰岛素血糖控制不佳糖尿病效果探讨%Effect Discussion on the Pioglitazone Hydrochloride in Treatment of Single-use Insulin in Poor Glycemic Control Diabetes

    Institute of Scientific and Technical Information of China (English)

    陈振领

    2015-01-01

    目的 探讨盐酸吡格列酮治疗单用胰岛素血糖控制不佳糖尿病患者临床应用效果.方法82例患者均保持原有胰岛素使用剂量不变并加用盐酸吡格列酮治疗,记录其治疗前后空腹血糖变化情况,将所得资料经专业分析后获得结论.结果 82例单用胰岛素血糖控制不佳糖尿病患者经盐酸吡格列酮治疗后,其空腹血糖较之前降低,对比结果具有统计学意义(P<0.05).结论 对单用胰岛素血糖控制不佳的糖尿病患者给予盐酸吡格列酮联合治疗后可获得满意的血糖控制效果,有利于保障其生活质量及生命安全.%Objective To explore the clinical application effect of pioglitazone hydrochloride in the treatment of insulin alone in poor glycemic control in diabetic patients. Methods 82 patients were using the same dose of insulin and treated with pioglitazone, recorded the changes of fasting blood-glucose before and after the treatment, the data obtained were given for professional analysis and then drew the Conclusion . Results 82 patients with insulin alone in poor glycemic control diabetes after treatment with pioglitazone, the fasting blood-glucose was significantly lower than before, the Results were statistically significant (P < 0.05). Conclusion If give the single-use insulin in poor glucose control diabetic patients pioglitazone hydrochloride for combined treatment , satisfactory blood glucose control effect will be obtained, and that is conducive to the protection of the quality of life and life safety.

  12. Comparison of efficacy and safety of ziprasidone hydrochloride and risperidone in treatment of schizophrenia%盐酸齐拉西酮与利醅酮治疗精神分裂症的疗效及安全性比较

    Institute of Scientific and Technical Information of China (English)

    卢殿军; 宁洁; 吴胜

    2011-01-01

    Objective To evaluate clinical efficacy and safety of ziprasidone hydrochloride and risperidone in treatment of schizophrenia. Methods 60 patients with schizophrenia in hospital were selected and randomly divided into ziprasidone group (n=30,ziprasidone administrated orally) and risperidone group(n=30 ,risperidone tablet administrated orally), with a 6 week course of treatment. Positive and negative syndrome scale(PANSS) was used to assess their clinical efficacy and the treatment emergent symptom scale(TESS) was adopted to investigate their safety. Results At the end of treatment, PANSS reduced score rate of ziprasidone group was(60.98±24.04)% ,and that of risperidone group was (62.03±28.29)% ,with no statistically significant difference between the two groups(P>0.05). Compared incidence rate of side effects of patients in ziprasidone group with that in risperidone group,no statistically significant difference was found between the two groups(P>0.05). Conclusion Ziprasidone hydrochloride is an effective and safe antipsychotic agent with similar curative efficacy and adverse reaction to risperidone.%目的 评价盐酸齐拉西酮与利培酮治疗精神分裂症的临床疗效及安全性.方法 选择住院精神分裂症患者60例,随机分为齐拉西酮组(n=30,口服盐酸齐拉西酮片)与利培酮组(n=30,口服利培酮片),疗程6周.采用精神分裂症阳性与阴性症状评定量表(PANSS)评价其临床疗效,不良反应量表(TESS)评价其安全性.结果 治疗结束时,齐拉西酮组PANSS减分率为(60.98±24.04)%,利培酮组PANSS减分率为(62.03±28.29)%,组间比较差异无统计学意义(P>0.05);齐拉西酮组不良反应发生率与利培酮组比较差异无统计学意义(P>0.05).结论 盐酸齐拉西酮的疗效及不良反应与利培酮相当,是有效、安全的抗精神病药物.

  13. Compound Pseudoephedrine Hydrochloride Oral Solution Treatment of Upper Airway Cough Syndrome 93 Cases of Clinical Observation%美敏伪麻溶液治疗上气道咳嗽综合征93例临床观察

    Institute of Scientific and Technical Information of China (English)

    李晓荣

    2012-01-01

    目的:观察美敏伪麻溶液治疗上呼吸道咳嗽综合征(UACS)的临床疗效、安全性.方法:93例UACS患者随机分为治疗组48例,给予美敏伪麻溶液,对照组45例,给予复方磷酸可待因溶液.观察两组患者治疗前后咳嗽症状积分、卡他症状群积分.结果:美敏伪麻溶液组临床总有效率为85.42%,复方磷酸可待因溶液组临床总有效率为77.78%,治疗效果无显著差异(P>0.05);在改善咳嗽症状方面,第7d与第14d比较差异有统计学意义(P0.05); In improving the symptoms of cough, 7 days and 14 days the difference was statistically significant (PO.05). In improving the symptoms of catarrh, 1 day, 2 days and 3 days the difference was statistically significant (P<0.05).Conclusion:Compound pseudoephedrine hydrochloride oral solution for the control card syndrome and cough syndrome was better than the compound codeine phosphate solution.

  14. Effect of the combination of metformin hydrochloride and melatonin on oxidative stress before and during pregnancy, and biochemical and histopathological analysis of the livers of rats after treatment for polycystic ovary syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Lemos, Ana Janaina Jeanine M. [Department of Animal Morphology and Physiology, Universidade Federal Rural de Pernambuco, Recife (Brazil); Unit of Medical and Health Sciences, Universidade Federal de Campina Grande (Brazil); Peixoto, Christina A. [Centro de Pesquisa Aggeu Magalhães-Fiocruz Recife (Brazil); Teixeira, Álvaro Aguiar C. [Department of Animal Morphology and Physiology, Universidade Federal Rural de Pernambuco, Recife (Brazil); Luna, Rayana Leal A.; Rocha, Sura Wanessa S. [Centro de Pesquisa Aggeu Magalhães-Fiocruz Recife (Brazil); Santos, Hilda Michelly P. [Department of Animal Morphology and Physiology, Universidade Federal Rural de Pernambuco, Recife (Brazil); Silva, Amanda Karolina S.; Nunes, Ana Karolina S. [Centro de Pesquisa Aggeu Magalhães-Fiocruz Recife (Brazil); Wanderley-Teixeira, Valéria, E-mail: valeria@dmfa.ufrpe.br [Department of Animal Morphology and Physiology, Universidade Federal Rural de Pernambuco, Recife (Brazil)

    2014-10-01

    The aim of the present study was to analyze the effect of a combination of metformin hydrochloride and melatonin on oxidative stress together with a biochemical and histopathological analysis of the livers of Wistar rats induced with PCOS. The results indicated that a combination of the drugs was more effective in the reduction of plasmatic levels of liver enzyme alanine aminotransferase, nitric oxide and total glutathione, and decreased the inflammatory response and histopathological damage, producing results that were significantly similar to animals from the control group. A mixture of the drugs produced more effective results against liver toxicity caused by PCOS, encouraging the normalization of biochemical parameters. During pregnancy, there was reduced oxidative stress compared to monotherapeutic use of these drugs. Interestingly, the combination of the drugs caused a physiological reaction similar to responses identified in healthy rats without induction of the PCOS control group. However, the clinical and physiological effectiveness of the combination should be further explored, especially with respect to the possible side effects on offspring. - Highlights: • Studies have documented increased oxidative stress in patients with PCOS. • It has been noted that women with PCOS have a high prevalence of liver alterations. • Liver disease in pregnancy may be pre-existing increasing the newborn mortality. • Metformin/melatonin associated reduced oxidative stress in liver in pregnant rats. • Association of metformin/melatonin normalizes hepatic biochemical parameters.

  15. Stability of paclitaxel with ondansetron hydrochloride or ranitidine hydrochloride during simulated Y-site administration.

    Science.gov (United States)

    Burm, J P; Jhee, S S; Chin, A; Moon, Y S; Jeong, E; Nii, L; Fox, J L; Gill, M A

    1994-05-01

    The stability of paclitaxel with either ondansetron hydrochloride or ranitidine hydrochloride during simulated Y-site injection at room temperature was studied. Triplicate test solutions of paclitaxel 0.3 and 1.2 mg/mL were admixed 1:1 with ondansetron 0.03 and 0.3 mg/mL (as the hydrochloride salt) or ranitidine 0.5 and 2.0 mg/mL (as the hydrochloride salt). Also, paclitaxel 1.2 mg/mL was admixed 1:1:1 with ondansetron 0.3 mg/mL and ranitidine 2.0 mg/mL. The solutions were stored in glass containers at room temperature, and samples were removed at zero, one, two, and four hours for immediate assay. At the time of the assay and before any dilution, each sample was visually inspected for clarity, color, and precipitation, and the pH was determined. Drug concentrations were measured by stability-indicating high-performance liquid chromatographic procedures. Throughout the study, more than 90% of the initial concentrations of paclitaxel, ondansetron, and ranitidine remained in the solutions. No precipitates, color changes, or haziness was seen. The changes in pH were minor. Paclitaxel in concentrations of 0.3 and 1.2 mg/mL was stable when mixed with either ondansetron (0.03 or 0.3 mg/mL, as the hydrochloride salt) or ranitidine (0.5 or 2.0 mg/mL, as the hydrochloride salt) and stored in glass containers for four hours. Paclitaxel 1.2 mg/mL was also stable when mixed with both ondansetron 0.3 mg/mL and ranitidine 2.0 mg/mL and stored in glass containers for four hours.

  16. Toxicity of naproxen sodium and its mixture with tramadol hydrochloride on fish early life stages.

    Science.gov (United States)

    Sehonova, Pavla; Plhalova, Lucie; Blahova, Jana; Doubkova, Veronika; Prokes, Miroslav; Tichy, Frantisek; Fiorino, Emma; Faggio, Caterina; Svobodova, Zdenka

    2017-08-31

    Pharmaceuticals occur in water bodies as a consequence of their incomplete removal during waste water treatment processes. The occurence of pharmaceuticals in surface waters as well as their possible impact on aquatic vertebrates have received considerable attention in recent years. However, there is still a lack of informations on the chronic effects of widely used drugs as well as their possible mixture toxicity on non-target aquatic vertebrates as well as their possible mixture toxicity. The aim of this study was to assess the effects of naproxen sodium on early life stages of fish and evaluate its mixture toxicity with tramadol hydrochloride, which was assessed in our earlier study as a single substance. Two embryo-larval toxicity tests with common carp (Cyprinus carpio) were performed according to the OECD guideline 210 (Fish, Early-life Stage Toxicity Test) in order to assess the subchronic toxicity of naproxen sodium and tramadol hydrochlorid-naproxen sodium mixture at the concentrations of 10; 50; 100 and 200 μg/L. These experiments were conducted for 32 days. The subchronic exposure to naproxen sodium and naproxen sodium and tramadol hydrochloride mixture had a strong effect on the early life stages of common carp. Hatching, developmental rate, morphology, histopathology and, in the case of the naproxen sodium and tramadol hydrochloride mixture, mortality were influenced. The bioindicators of oxidative stress were also influenced. The LOEC was determined at 10 μg/L for both naproxen sodium and naproxen sodium and tramadol hydrochloride mixture. Copyright © 2017. Published by Elsevier Ltd.

  17. 盐酸哌甲酯控释剂治疗儿童注意缺陷与多动障碍的疗效探析%The Clinical Observation of Methylphenidate Hydrochloride Controlled Re-lease Tablets in the Treatment of Attention Deficit and Hyperactivity Disor-der in Children

    Institute of Scientific and Technical Information of China (English)

    贾小红

    2015-01-01

    目的:探析盐酸哌甲酯控释剂治疗儿童注意缺陷与多动障碍效果。方法整群选择2012年6月—2014年8月该院儿科多动症门诊就诊的132例注意缺陷与多动障碍患儿。并随机分为控释组(72例)与速释组(60例),控释组患儿给予盐酸哌甲酯控释片治疗,速释组患儿给予速释哌甲酯片治疗。观察给药2周、6个月后两组患儿用药依从性、用药不良反应、行为及注意力改善情况。结果两组患儿用药后不良反应均较轻。给药2周、6个月后控释组临床有效率分别为98.6%、94.4%,均优于速释组的91.7%、53.3%(P<0.05),比较给药1个月后两组患儿用药依从性不太明显,给药3个月、6个月及12个月后,控释组患儿依从性则明显优于速释组(P<0.05)。结论对于儿童注意缺陷多动障碍,应用哌甲酯控释剂治疗不仅能显著提高患儿注意力与认知功能,而且药物不良反应少,患儿依从性高。%Objective To study the effect of methylphenidate hydrochloride controlled release tablets in the treatment of at-tention deficit and hyperactivity disorder in children. Methods 132 cases of children with attention deficit and hyperactivity disorder treated in our hospital from June 2012 to August 2014 were selected and randomly divided into control group (72 cases) and rapid release group (60 cases), patients in the control group were given methylphenidate hydrochloride controlled release tablets treatment and patients in the rapid release group were given rapid release of methyl ester hydrochloride tablets treatment. After 2 weeks and 6 months from giving medicine, Medication compliance, adverse drug reactions and the improvement of behavior and attention of the two groups were observed. Results The adverse reactions of the two groups after taking medicine were mild. After 2 weeks and 6 months from giving medicine, the clinical effective rate of the control group was 98.6% and 94

  18. Betahistine hydrochloride in Méniére's disease.

    Science.gov (United States)

    Frew, I J; Menon, G N

    1976-08-01

    A double-blind, placebo-controlled, cross-over clinical trial was performed to assess the effect of betahistine hydrochloride (Serc) in Ménière's disease. The diagnosis was based on paroxysmal attacks of rotational vertigo, with tinnitus, and a fluctuating sensori-neural deafness, together with the results of auditory and vestigular tests. Twenty-eight patients were admitted to the trial over 3 years. Twenty-two patients completed the trial. In total, they received betahistine 32 mg daily, for a period of 16 weeks, and placebo also for the same length of time, preceded in every case by a 4-week pre-treatment period. Daily symptom score cards were kept. There was a statistically significant improvement in favour of the drug with regard to vertigo, tinnitus and deafness. Vertigo was the most responsive symptom. No adverse reactions were observed.

  19. Simultaneous determination of pseudoephedrine hydrochloride and cetrizine hydrochloride by reverse phase high performance liquid chromatography

    Directory of Open Access Journals (Sweden)

    Nalini C

    2006-01-01

    Full Text Available A reversed phase high performance liquid chromatographic method has been developed using Shimadzu HPLC-VP series, LC-10 ATV pump, SPD10 AVP and C8 column, for simultaneous determination of pseudoephedrine hydrochloride and cetrizine hydrochloride in three marketed tablet formulations (extended release. The mobile phase consists of phosphate buffer of pH 7.0 and acetonitrile HPLC grade in the ratio of 1:1. The flow rate was maintained at 1 ml/min and the ultraviolet detection was done at 242 nm, which is the isosbestic point. Linearity coefficients, assay values, recovery studies and repeatability studies showed that the method is accurate and precise.

  20. Ecotoxicological assessment of the pharmaceutical fluoxetine hydrochloride and the surfactant dodecyl sodium sulfate after their submission to ionizing radiation treatment; Avaliacao ecotoxicologica do farmaco cloridrato de fluoxetina e do surfactante dodecil sulfato de sodio quando submetidos a tratamento por radiacao ionizante

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Dymes Rafael Alves dos

    2011-07-01

    The use of pharmaceuticals and personal care products and the consequent and continuous input of this substances in the environment generates an increasing need to investigate the presence, behavior and the effects on aquatic biota, as well as new ways to treat effluents containing such substances. Fluoxetine hydrochloride is an active ingredient used in the treatment of depressive disorders and anxiety. As the surfactant sodium dodecyl sulfate is present in many cleaning and personal care products. The present study aimed on assessing the acute toxicity of fluoxetine hydrochloride, sodium dodecyl sulfate and the mixture of both to the aquatic organisms Hyalella azteca, Daphnia similis and Vibrio ficheri. Reducing the toxicity of fluoxetine and the mixture after treatment with ionizing radiation from industrial electron beam accelerator has also been the focus of this study. For Daphnia similis the average values of CE50-4{sub 8h} found for the non-irradiated drug, surfactant and mixture were 14.4 %, 9.62 % and 13.8 %, respectively. After irradiation of the substances, the dose 5 kGy proved itself to be the most effective dose for the treatment of the drug and the mixture as it was obtained the mean values for CE50{sub 48h} 84.60 % and > 90 %, respectively. For Hyalella azteca the acute toxicity tests were performed for water column with duration of 96 hours, the mean values for CE50{sub 96h} found for the drug, the surfactant and the mixture non-irradiated were 5.63 %, 19.29 %, 6.27 %, respectively. For the drug fluoxetine and the mixture irradiated with 5 kGy, it was obtained 69.57 % and 77.7 %, respectively. For Vibrio ficheri the acute toxicity tests for the untreated drug and the drug irradiated with 5 kGy it was obtained CE50{sub 15min} of 6.9 % and 32.88 % respectively. These results presented a reduction of the acute toxicity of the test-substances after irradiation. (author)

  1. 盐酸氨溴索和糜蛋白酶不同雾化方式治疗新生儿肺炎的临床疗效%Clinical Effect of Different Atomization Methods of Ambroxol Hydrochloride and Chymotrypsin in the Treatment of Neonatal Pneumonia

    Institute of Scientific and Technical Information of China (English)

    许英

    2015-01-01

    目的:研究盐酸氨溴索(沐舒坦)和糜蛋白酶不同雾化方式对治疗新生肺炎患儿的临床效果。方法选取90例新生儿肺炎随机分成对照组与研究组各45例。两组都进行常规治疗,都给予沐舒坦和糜蛋白酶进行治疗,对照组采取超声雾化法进行给药,研究组采取氧驱动雾化法进行给药。结果研究组咳嗽、肺部啰音以及气喘等临床症状的完全消失时间都比对照组短;研究组总有效率高达97.2%,高于对照组的85.4%(P<0.05)。结论对于新生肺炎患儿采取氧驱动雾化法给药进行治疗比超声雾化法给药治疗效果更好。%Objective To study clinical effect of different atomization methods of Ambroxol hydrochloride and chymotrypsin in the treatment of neonatal pneumonia.Methods 90 cases of neonatal pneumonia were randomly divided into control group and research group ,45 cases each.Both groups were given ambroxol hydrochloride and chymotrypsin treatment.In control group, ultrasonic atomization method was taken to the team and observation group took oxygen drive atomization method.Results The team cough, lung sounds and asthma clinical symptoms disappear time was shorter than the control group; Group total effective rate 97.2% was significantly higher than the 85.4% in the control group (P< 0.05).Conclusion Newborn pneumonia of children take oxygen atomization method for drug treatment is better than ultrasonic atomization method.

  2. A Systematic Review of Therapeutic Efficacy and Safety of Atomoxetine Hydrochloride in the Treatment of Attention Deficit Hyperactivity Disorder in Children%盐酸托莫西汀治疗儿童注意缺陷多动障碍疗效与安全性的系统评价

    Institute of Scientific and Technical Information of China (English)

    杨红双; 马爱霞

    2015-01-01

    Objective:To assess the efficacy and safety of atomoxetine hydrochloride in the treatment of attention deficit hyperactivity disorder( ADHD).Methods: 7 comparative studies of tomoxetine hydrochloride in the treatment of ADHD were analyzed by Meta-analysis.Results:A total of 7 RCTs were included.The sample size was 1304 patients.Results of Meta-analysis showed that the im-provement of ADHD-RS[MD=-5.86,95%CI( -7.73,-3.99),P<0.00001]、ADHD-RS hyperactivity/impulsive[MD=-2.64, 95%CI(-3.75,-1.52),P<0.00001],ADHD-RS inattention[MD=-2.35,95%CI( -3.87,-0.83),P<0.00001]in atomoxetine hydrochloride group were significantly greater than in control group.The incidence of abdominal pain,nausea,somnolence,decreased appe-tite and vomiting in atomoxetine group were higher than in control group ( P<0.05).Conclusion:Atomoxetine is effective in the treat-ment of children with ADHD and can improve hyperactivity/impulsivity and attention deficit in children with ADHD.But the side effects of them should be considered.%目的:探讨盐酸托莫西汀治疗儿童注意缺陷多动障碍( ADHD)的疗效和安全性。方法:计算机检索相关医学数据库,采用Meta分析对7项盐酸托莫西汀与安慰剂对比治疗ADHD对照研究的文献进行分析。结果:本研究纳入7篇文献,均为国外文献( Jadad评分≥3分);样本含量为1304例;Meta分析结果显示,治疗后盐酸托莫西汀组的注意缺陷/多动评定量表( ADHD-RS)总分值[MD =-5.86,95%CI(-7.73,-3.99),P<0.00001]、ADHD-RS多动/冲动分量表分值[MD =-2.64,95%CI (-3.75,-1.52),P<0.00001]、ADHD-RS注意缺陷分量表分值[MD=-2.35,95%CI(-3.87,-0.83),P<0.00001]改善均显著优于对照组,两组比较有显著性差异;盐酸托莫西汀组患儿比对照组更容易发生腹痛、恶心、呕吐、嗜睡和食欲减退等不良反应( P<0.05)。结论:盐酸托莫西汀治疗儿

  3. 盐酸文拉法辛缓释胶囊治疗广泛性焦虑障碍合并抑郁障碍的临床对照研究%Venlafaxine hydrochloride in the treatment of generalized anxiety disorder comorbidity with depressive disorder

    Institute of Scientific and Technical Information of China (English)

    李爱萍

    2010-01-01

    Objective To evaluate the efficacy and safety of venlafaxine hydrochloride in the treatment of generalized anxiety disorder comorbidity with depressive disorder. Methods 68 patients with gernalized anxiety disorder comorbisity with depressive disorder were randomly assigned into the velafaxine group and the placebo group. All the patients were treated for 8 weeks. The efficacy were measured with Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) and Clinical General Inventory(CGI). The safety was measured with Treatment Emergent SymptomScale (TESS). Results The response rate of venlafaxine group was 82.4%,which was statically higher than that of the placebo group. There were less and mild side effects in the venlafaxine group. Conclusion Venlafaxine hydrochloride is an effective and safe anti-anxiety and antidepressant.%目的 评价盐酸文拉法辛缓释胶囊(怡诺思)治疗广泛性焦虑障碍合并抑郁障碍的临床疗效和不良反应.方法 68例广泛性焦虑障碍合并抑郁障碍患者随机分为两组,分别予盐酸文拉法辛缓释胶囊(怡诺思)和安慰剂治疗,疗程8周.用汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)、临床总体印象量表(CGI)评价其疗效,药物副反应量表(TESS)评价不良反应.结果 盐酸文拉法辛缓释胶囊组显效率82.4%,明显优于安慰剂组,不良反应少而轻.结论 盐酸文拉法辛缓释胶囊可作为一种安全有效的抗焦虑抑郁药物.

  4. 氨基葡萄糖片联合玻璃酸钠注射液治疗膝关节骨性关节炎的临床疗效分析%Clinical effect of glucosamine hydrochloride combined with sodium hyaluronate in the treatment of knee osteoarthritis

    Institute of Scientific and Technical Information of China (English)

    黎爱芬; 何伟平; 何志雄

    2014-01-01

    目的 探讨氨基葡萄糖片联合玻璃酸钠注射液治疗膝关节骨性关节炎的临床疗效.方法 选择我院于2012年3月至2013年9月收治的膝关节骨性关节炎的患者142例,随机分为A、B、C三组,其中A组患者采用玻璃酸钠注射液治疗,B组采用氨基葡萄糖片治疗,C组患者采用玻璃酸钠注射液联合氨基葡萄糖片治疗,综合比较三组患者临床治疗效果.结果 治疗后A组疼痛改善(1.2±0.4)分、B组改善(1.1±0.3)分、C组改善(1.9±0.7)分,C组联合用药疼痛改善效果明显优于A、B组单独用药(P<0.05),三组患者在疗效持续时间、疗效起效时间、关节消肿时间以及治疗前后运动功能评分差值比较差异均有统计学意义(P<0.05).而联合用药的C组患者各项临床指标优于单独用药的患者(P<0.05).通过综合考察患者肢体活动度、压痛、活动痛、休息痛、肿痛等五个方面,提示三组患者临床治疗效果差异较大(u>ua,P< 0.05),C组治疗效果远优于单独用药的A组及B组(P<0.05).结论 玻璃酸钠注射液在改善关节肿胀、功能活动以及维持药效等方面效果显著,而氨基葡萄糖对于改善关节疼痛和关节受限等方面有一定效果,联合使用两者能够迅速减缓膝关节骨性关节炎临床症状,效果持久,值得临床推广应用.%Objective To investigate the clinical effect of glucosamine hydrochloride combined with sodium hyaluronate in the treatment of knee osteoarthritis.Methods 142 cases of knee osteoarthritis in our hospital from March 2012 to September 2013 were randomly divided into group A,group B and group C.Group A was treated with sodium hyaluronate,group B was treated with glucosamine hydrochloride,group C was treated with sodium hyaluronate and glucosamine hydrochloride.The clinical efficacy was compared after treatment.Results Pain relief improvement in group A was (1.2 ± 0.4),(1.1 ± 0.3) in group B,(1.9 ± 0.7) in group C

  5. 盐酸二甲双胍治疗多囊卵巢综合征对排卵和子宫内膜容受性的影响%Effect on ovulation and endometrial receptivity of metformin hydrochloride in the treatment of polycystic ovary syn-drome

    Institute of Scientific and Technical Information of China (English)

    叶飞雪

    2014-01-01

    Objective To analyze effect on ovulation and endometrial receptivity of metformin hydrochloride in the treatment of polycystic ovary syndrome. Methods 49 patients with polycystic ovary syndrome selected from Jun 2012 to Mar 2014 in our hospital were retrospectively analyzed and treated as the observation group , the whole group of patients had insulin resistance. Selected 49 cases of patients with polycystic ovary syndrome in our hospital at the corresponding period and they were treated as the control group, this group of patients had spontaneous ovulation. Observation group was treated with metformin hy-drochloride therapy, the control group took no medication. Compared the interstitial gland integrin αv, β3 expression and PR, ER, AR expression of two groups. Results The total ovulation rate of patients with polycystic ovary syndrome taken medica-tion was 29.23%, the observation group before ovulation, endometrial thickness were significantly higher than those of the con-trol group, there were significant differences between the two groups (P<0.05). Interstitial gland integrin αv, β3 expression of observation group were significantly higher than those of the control group, PR, ER, AR expression were significantly lower than those of the control group, there was significant difference in the two groups (P<0.05). Conclusion The treatment of polycystic ovary syndrome with metformin hydrochloride can increase ovulation rate , endometrial thickness and improve en-dometrial receptivity.%分析盐酸二甲双胍治疗多囊卵巢综合征对排卵和子宫内膜容受性的影响。方法对2012年6月~2014年3月来我院就诊的49例多囊卵巢综合征患者进行回顾性分析并将其作为观察组,本组患者均伴有胰岛素抵抗;选取同期来我院就诊的49例多囊卵巢综合征患者作为对照组,本组患者均有自发排卵。观察组口服盐酸二甲双胍治疗,对照组不服用任何药物。比较两组间

  6. 21 CFR 520.1660b - Oxytetracycline hydrochloride capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Oxytetracycline hydrochloride capsules. 520.1660b Section 520.1660b Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Oxytetracycline hydrochloride capsules. (a) Specifications. The drug is in capsule form with each capsule...

  7. 21 CFR 520.2345a - Tetracycline hydrochloride capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Tetracycline hydrochloride capsules. 520.2345a... Tetracycline hydrochloride capsules. (a) Specifications. Each capsule contains 50, 100, 125, 250, or 500... as in paragraph (c) of this section: (1) No. 000009: 250 mg per capsule. (2) No. 000069: 125, 250, or...

  8. 21 CFR 520.1242f - Levamisole hydrochloride gel.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Levamisole hydrochloride gel. 520.1242f Section 520.1242f Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Levamisole hydrochloride gel. (a) Specifications. The drug is a gel containing 11.5 percent...

  9. 21 CFR 520.1242 - Levamisole hydrochloride oral dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Levamisole hydrochloride oral dosage forms. 520.1242 Section 520.1242 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1242 Levamisole hydrochloride oral dosage...

  10. 21 CFR 520.1242e - Levamisole hydrochloride effervescent tablets.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Levamisole hydrochloride effervescent tablets. 520.1242e Section 520.1242e Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1242e Levamisole hydrochloride...

  11. 21 CFR 522.1222 - Ketamine hydrochloride injectable dosage forms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Ketamine hydrochloride injectable dosage forms. 522.1222 Section 522.1222 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... ANIMAL DRUGS § 522.1222 Ketamine hydrochloride injectable dosage forms. ...

  12. 盐酸羟考酮控释片联合普瑞巴林治疗癌性神经病理性疼痛的临床研究%Clinical study of oxycodone hydrochloride controlled-release tablets combined with pregabalin in the treatment of malignant neuropathic pain

    Institute of Scientific and Technical Information of China (English)

    陈强; 李焕丽; 何斐; 郭素香

    2014-01-01

    目的:观察盐酸羟考酮控释片联合普瑞巴林治疗癌性神经病理性疼痛的临床疗效及不良反应。方法选择疼痛门诊治疗的癌性疼痛患者87例,口服盐酸羟考酮控释片1周,并进行随访调查。接受治疗患者第8天11点数字分级法评定( NRS)﹤4入A组,继续给予羟考酮治疗2周;NRS≥4随机入B1、B2组,B1组继续服用羟考酮2周, B2组联合普瑞巴林治疗2周。观察三组患者的疼痛评分及不良反应情况。结果84例(96.55%)完成第一阶段治疗。在第二阶段A组、B1组、B2组分别有28、27、26例患者。三组疼痛评分第15天均降低,第22天无改善,B2组比B1组第22天疼痛评分降低,但差异无统计学意义(P﹥0.05)。B2组羟考酮用量比B1组明显减少(P﹤0.05)。三组不良反应观察中便秘发生率最高,分别为17.9%、29.6%、34.6%。结论盐酸羟考酮控释片联合普瑞巴林治疗癌性神经病理性疼痛疗效明确,能够减少盐酸羟考酮控释片用量,是治疗癌性疼痛性价比较高的方案。%Objective To observe the clinical effect and adverse reactions of oxycodone hydro-chloride controlled-release tablets combined with pregabalin in the treatment of malignant neuropathic pain. Methods Eighty-seven patients with cancer pain admitted in pain clinic were chose,oxycodone hydro-chloride controlled-release tablets were orally given for 1 week,and the patients were followed-up. On the eighth day,patients with numeric rating scale( NRS)﹤4 were enrolled in group A,and were given oxyc-odone treatment for another 2 weeks. Patients with NRS≥4 were randomly divided into group B1 and group B2,the patients in group B1 were given oxycodone for another 2 weeks,and patients in group B2 were given combined treatment of oxycodone and pregabal for 2 weeks. The pain scores and adverse reactions were ob-served among the three groups. Results Eighty-four patients( 96. 55%)completed the

  13. Neonatal DSP-4 treatment impairs 5-HT(1B) receptor reactivity in adult rats. Behavioral and biochemical studies.

    Science.gov (United States)

    Ferdyn-Drosik, Marzena; Nowak, Przemysław; Bojanek, Kamila; Bałasz, Michał; Kasperski, Jacek; Skaba, Dariusz; Muchacki, Rafał; Kostrzewa, Richard M

    2010-01-01

    To examine the effect of a central noradrenergic lesion on the reactivity of the 5-HT(1B) receptor we compared intact male rats with rats in which noradrenergic nerve terminals were largely destroyed with the neurotoxin DSP-4 (50 mg/kg x 2, on the 1st and 3rd days of postnatal life). When rats attained 10 weeks of age, control and DSP-4 rats were divided into two subgroups receiving either saline or the serotonin (5-HT) synthesis inhibitor (p-chlorophenylalanine; p-CPA; 100 mg/kg). Employing an elevated plus maze test, we demonstrated that CP 94,253 (5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride) (4.0 mg/kg; 5-HT(1B) agonist) induced an anxiogenic-like action in control rats; however, it failed to elicit this effect in the DSP-4 group. Surprisingly, in p-CPA pretreated rats anxiogenic-like activity was observed both in control and DSP-4 treated rats. CP 94,253 significantly attenuated 5-HT synthesis in the medial prefrontal cortex (mPFC) of control rats, and SB 216641 (N-{3-[3-(dimethylamino)ethoxy]-4-methoxyphenyl}-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride) (4.0 mg/kg; 5-HT(1B) antagonist) was able to antagonize this effect. Conversely, CP 94,253 failed to significantly inhibit the 5-HT synthesis rate in DSP-4-treated rats. In the microdialysis study CP 94,253 induced long-lasting attenuation of 5-HT release in the mPFC of control rats but had no effect in DSP-4 rats. These data lead to the proposal that presynaptic 5-HT(1B) autoreceptors underwent desensitization in DSP-4 treated rats.

  14. 胰岛素联合西格列汀二甲双胍片治疗2型糖尿病肥胖心功能不全患者的疗效观察%Treatment effect observation of insulin combined with Sitagliptin Phosphate/metformin Hydrochloride Tablets in treating type 2 diabetic obesity heart failure

    Institute of Scientific and Technical Information of China (English)

    由晓丹

    2015-01-01

    目的:研究胰岛素联合西格列汀二甲双胍片治疗2型糖尿病肥胖心功能不全患者的疗效。方法将2012年8月—2014年8月期间该院收治的76例2型糖尿病肥胖伴心功能不全患者纳入研究,随机分为两组,对照组患者仅给予胰岛素治疗,观察组患者给予胰岛素联合西格列汀二甲双胍片治疗,比较两组患者的血糖情况、胰岛素用量、心功能情况。结果(1)血糖情况:观察组患者的空腹血糖、餐后血糖、糖化血红蛋白含量低于对照组;(2)胰岛素抵抗:观察组患者的 HOMA-IR、单日胰岛素用量低于对照组;(3)心功能情况:观察组患者的E峰值、LVEDD、LVEF高于对照组。结论胰岛素联合西格列汀二甲双胍片治疗有助于控制血糖水平、改善胰岛素抵抗和心功能,是治疗2型糖尿病肥胖患者伴心功能不全的理想方法。%Objective To study effect of insulin combined with Sitagliptin Phosphate/metformin Hydrochloride Tablets in treating type 2 diabetic obesity heart failure. Methods 76 cases of type 2 diabetic obesity heart failure patients in our hospital from 2012 March to 2014 April were enrolled and randomly divided into two groups. Control group received insulin therapy, observation group received insulin combined with Sitagliptin Phosphate/metformin Hydrochloride Tablets. Then blood glucose, insulin dosage, heart function were compared. Results (1): blood glucose condition:fasting blood glucose, postprandial blood glucose and glycosy-lated hemoglobin content of observation group were lower than those of the control group;(2)insulin resistance: HOMA-IR, daily insulin dosage of observation group were lower than those of control group;(3)heart function:E peak, LVEDD, LVEF of observation group were higher than those of control group. Conclusion insulin combined with Sitagliptin Phosphate/metformin Hydrochloride treatment is helpful to control blood sugar levels, improve

  15. Clinical observation of Zhongtong'an Capsules combined with minocycline hydrochloride in treatment of wisdom tooth pericoronitis%肿痛安胶囊联合盐酸米诺环素治疗智齿冠周炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    王健; 秦兴军

    2016-01-01

    目的 探讨肿痛安胶囊联合盐酸米诺环素治疗智齿冠周炎的临床疗效.方法 选取2015年1月-2016年1月上海市奉贤区奉城医院收治的智齿冠周炎患者106例,随机分为对照组和治疗组,每组各53例.对照组给予盐酸米诺环素软膏,置入牙周袋中,直至部分溢出为止,1次/d.治疗组在对照组治疗的基础上口服肿痛安胶囊,2粒/次,3次/d.两组患者均连续治疗5 d.观察两组的临床疗效,同时比较两组治疗前后革兰氏染色情况、牙龈指数(GI)、疼痛缓解情况.结果 治疗后,对照组和治疗组的总有效率分别为84.91%、96.23%,两组比较差异具有统计学意义(P<0.05).治疗后,两组患者细菌密度、螺旋体、G-菌、GI均显著降低,G+菌显著升高,同组治疗前后差异具有统计学意义(P<0.05);且与对照组相比,治疗组这些指标的改善程度更显著,两组比较差异有统计学意义(P<0.05).治疗后,两组患者疼痛0级人数显著增加,疼痛1、2、3级人数显著减少,同组治疗前后差异具有统计学意义(P<0.05);治疗后,治疗组疼痛0级人数多于对照组,2级人数显著少于对照组,两组比较差异有统计学意义(P<0.05).结论 肿痛安胶囊联合盐酸米诺环素治疗智齿冠周炎具有很好的临床效果,能改善盲袋内革兰氏染色情况,缓解患者疼痛,具有一定的临床推广应用价值.%Objective To investigate the clinical efficacy of Zhongtong'an Capsules combined with minocycline hydrochloride in treatment of wisdom tooth pericoronitis.Methods Patients (106 cases) with wisdom tooth pericoronitis in Fengxian Hospital of Fengxian District in Shanghai from January 2015 to January 2016 were randomly divided into the control and treatment groups, and each group had 53 cases. Patients in the control group were given Minocycline Hydrochloride Ointment in periodontal pocket until some overflow, once daily. The patients in the treatment group werepoadministered with

  16. Study on the Effect of Different Types of Application of Donepezil Hydrochloride in the Treatment of Senile Dementia%不同类型老年痴呆应用盐酸多奈哌齐治疗的效果研究

    Institute of Scientific and Technical Information of China (English)

    刘颖

    2016-01-01

    Objective To investigate the donepezil hydrochloride in treating different types of dementia effect.Methods Simple-mental state examination (MMSE) and activities of daily living scale (ADL) to evaluate different types of alzheimer's patients to take effect ares treatment.Results After treatment, MMSE score mixed dementia, alzheimer's disease (AD) has significantly increased (P<0.05), after treatment, ADL blood of AD patients have signiifcantly decreased (P<0.05).Conclusion Ares treatment of senile dementia and mixed dementia has a good part of the effect, and vascular dementia largely ineffective.%目的:探讨盐酸多奈哌齐治疗不同类型老年痴呆的效果。方法用简易智能精神状态检查量表(MMSE)与日常生活活动能力量表(ADL)评估不同类型老年痴呆患者采取盐酸多奈哌齐治疗的效果。结果治疗后混合型痴呆、老年性痴呆(AD)MMSE评分增高(P<0.05);治疗后血AD患者ADL降低(P<0.05)。结论阿瑞斯治疗老年性痴呆与部分混合型痴呆有较好效果,而对血管性痴呆基本无效。

  17. [POLYHEXAMETHYLENE BIGUANID HYDROCHLORIDE (BIGUANELLE) THERAPY OF BACTERIAL VAGINOSIS].

    Science.gov (United States)

    Kovachev, S; Ganovska, A; Sultanov, E; Ivanova, S; Gizdov, N; Nikolova, L; Iliev, V

    2016-01-01

    The aim of our study was to determine the efficacy and tolerability of local therapy with polyhexamethylene biguanid hydrochloride (BIGUANELLE) in women with anaerobic vaginal infection. We include in our study 23 women (18-50) with established by AMSEL criteria bacterial vaginosis. In all of the women at the beginning and at the end of the survey was performed gynecological examination and microbiological research (AMSEL). The therapeutic scheme at all women is with a single vaginal application of gynecological solution BIGUANELLE. Effectiveness of the treatment was evaluated according to clinical complaints and microbiological research (Amsel criteria: Ph 4.5 >; KOH (+); "clue cells"; specific vaginal fluorine). Tolerability of patients to treatment was assessed by questionnaire. Clinical complaints of patients after the therapy decreased as follows: vaginal fluorine with 73.9%; odor--75%; pruritus--50%; discomfort--90%. Microbiological research and their evaluation by AMSEL, showed the therapeutic efficacy of the therapy in 16 (69.6%) of all (n-23) patients. At 7 (30.4%) women, the treatment remained without effect. At questionnaire answers, 73.9% patients were satisfied with the application of BIGUANELLE, 95.6% of them have implemented it easily, 95.6% of women believe that BIGUANELLE is more convenient to use in comparison with similar products which have a daily application, and none of the patients (100%) have any complaints in applying this gynecological solution. BIGUANELLE showed good clinical efficacy in the treatment of bacterial vaginosis. It is easily applied and well tolerated by the patients.

  18. Xylometazoline hydrochloride nasal spray combined with laser artificial nasolacrimal duct implantation for nasolacrimal duct obstruction

    Directory of Open Access Journals (Sweden)

    Xiao-Zhao Yang

    2017-02-01

    Full Text Available AIM: To study the role of xylometazoline hydrochloride nasal spray in combination therapy of nasolacrimal duct obstruction and to investigate the effect of nasal inflammation on nasolacrimal duct obstruction. METHODS: Totally 279 patients with nasolacrimal duct obstruction were collected, who received lacrimal passage irrigation, CT angiography for lacrimal passage and nasal endoscope before treated by lacrimal laser forming and artificial nasolacrimal duct implantation combined with xylometazoline hydrochloride nasal spray. In group A, 137 patients were treated with antibiotic eye drop and non-steroidal anti-inflammatory drugs after operations. In group B, 142 patients were treated with xylometazoline hydrochloride nasal spray besides the same treatment for group A. RESULTS:In the 279 patients 217(77.8%, in which 105 cases(76.6%were in group A and 112 cases(78.9%were in group B, were suffered with nasal inflammation, including nasal mucosal hyperemia, inferior turbinate hypertrophy, middle turbinate hypertrophy. At 3mo after the ducts were drawn, efficacy of group B was 95.8%, which was significant better than that of group A(86.1%, PCONCLUSION: Nasal inflammation was an important factor in the incidence of nasolacrimal duct obstruction, which shoud pay more attention in the process of diagnosis and treatment. Combination therapy could improve the cure rate of nasolacrimal duct obstruction.

  19. 加巴喷丁联合低剂量盐酸羟考酮缓释片治疗老年糖尿病周围神经痛的随机对照研究%GABAPENTIN COMBINED WITH LOW DOSE PROLONGED-RELEASE OXYCODONE HYDROCHLORIDE FOR THE TREATMENT OF ELDERLY PATIENTS WITH DIABETIC PERIPHERAL NEUROPATHIC PAIN

    Institute of Scientific and Technical Information of China (English)

    张春驰; 李小梅; 董艳娟; 何跃

    2013-01-01

    Objective:To observe and evaluate the analgesic efficacy and safety of gabapentin combined with low dose prolonged-release oxycodone hydrochloride for the treatment of diabetic peripheral neuropathic pain (DPNP).Method:A total of 70 elderly patients with DPNP were randomized into 2 groups (each contains 35 cases),one accepted gabapentin monotherapy (G1),and the other received both gabapentin and low dose prolonged-release oxycodone hydrochloride (G2).The initial dose of gabapentin was 100 mg/d and gradually titrated.The dose of prolonged-release oxycodone hydrochloride was fixed at 10 mg/q 12 h,and the therapy keeps 2 weeks.VAS was evaluated before and at the 8th and 15th day of the treatment.Side effects were observed and recorded.Results:Totally 62 (G1 =30,G2 =32) patients completed the 2 weeks treatment.Basic characteristics have no significant difference including mean VAS scores between the 2 groups.After the treatment,the total rate of pain relief at the 8th and 15th day were significantly higher in G 1 compared with G2 (P < 0.05) and the rate of excellent pain relief in G1 was higher than G2 at the 8th day (P < 0.05).The mean daily dose of gabapentin at the 8th day have no significant difference between G1 and G2,but at the 15th day,G2 was significant higher than G1 (P < 0.05).The occurrence rate of constipation in G2 was obviously higher compared with G1 (P < 0.05).Conclusion:Gabapentin monotherapy or combined with low dose Prolongedrelease oxycodone hydrochloride could effectively release elderly patients' DPNP,and the efficacy of the combination therapy was better,but should give preventive measures to constipation.%目的:观察加巴喷丁联合低剂量盐酸羟考酮缓释片治疗老年糖尿病周围神经痛(diabeticperipheral neuropathic pain,DPNP)的疗效及安全性.方法:70例老年DPNP患者随机均分为两组(n=35),分别接受2周加巴喷丁单药(单药组)或加巴喷丁联合低剂量盐酸羟考酮缓释

  20. 小儿智力糖浆联合盐酸哌甲酯片治疗儿童注意缺陷多动障碍的疗效观察%Clinical observation of Xiaoer Zhili Syrup combined with Methylphenidate Hydrochloride Tablets in treatment of attention deficit hyperactivity disorder

    Institute of Scientific and Technical Information of China (English)

    朱小冰

    2015-01-01

    目的:探讨小儿智力糖浆联合盐酸哌甲酯片治疗儿童注意缺陷多动障碍的临床疗效。方法选择2012年1月—2014年12月重庆市开县人民医院儿科收治儿童注意缺陷多动障碍患者90例,随机分为对照组和治疗组,每组45例。对照组患者口服盐酸哌甲酯片,2片/次,1次/d。治疗组患者在对照组的治疗基础上口服小儿智力糖浆,10 mL/次,2次/d。3周为1个疗程,全部患者均治疗3个疗程。观察两组的临床疗效,同时比较两组治疗前后Conner行为评定量表各因子评分及不良反应情况。结果治疗后,对照组和治疗组总有效率分别为77.78%、88.89%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者冲动多动、多动指数、学习问题、品行问题、焦虑、身心问题评分均较较治疗前显著降低,同组治疗前后差异有统计学意义(P<0.05);且治疗组治疗后各评分均显著低于对照组,两组比较差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论小儿智力糖浆联合盐酸哌甲酯片治疗儿童注意缺陷多动障碍,能够显著提高临床疗效,且无严重不良反应,具有一定的临床推广价值。%Objective To investigate the clinical effect of Xiaoer Zhili Syrup combined with Methylphenidate Hydrochloride Tablets in treatment of attention deficit hyperactivity disorder.Methods Patients (90 cases) with attention deficit hyperactivity disorder in the derpartment of paediatrics of People’s Hospital of Kaixian County in Chongqing from January 2012 to December 2014 were randomly divided into control and treatment groups. Each group had 45 cases. Patients in control group werepo administered with Methylphenidate Hydrochloride Tablets, 2 tablets/time, once daily. Patients in treatment group werepo administered with Xiaoer Zhili Syrup on the basis of the control group, 10 m

  1. [Neuropharmacological studies on tolperisone hydrochloride (author's transl)].

    Science.gov (United States)

    Fujii, Y; Ishii, Y; Suzuki, T; Murayama, S

    1979-10-01

    Neuropharmacological properties of tolperisone hydrochloride (2,4'-dimethyl-3-piperidinopropiophenone hydrochloride) were investigated in mice, rats and cats. Tolperisone inhibited the spontaneous movement and methamphetamine-induced hyperactivity in mice and the ED50 was approx. 50 mg/kg, s.c. At this dose, tolperisone did not prolong the pentobarbital-induced sleeping time. Tolperisone inhibited convulsions induced by pentylenetetrazol, nicotine and maximum electric shock, but did not affect convulsions induced by strychnine and picrotoxin. Tolperisone induced muscle relaxation in mice and rats in several pharmacological tests, but did not affect neuro-muscular transmission. Tolperisone did not affect conditioned avoidance response in rats and methamphetamine-induced rotational behaviour in nigro-lesioned rats. Tolperisone reduced decerebrated rigidity in cats with i.v. administration of 5 approximately 10 mg/kg and intraduodenal administration of 50 approximately 100 mg/kg. Tolperisone elicited a slight drowsy pattern in the spontaneous EEG of cats at 5 approximately 10 mg/kg, i.v., and inhibited the EEG arousal response and pressor response to stimulation of mesencephalic reticular formation or posterior hypothalamic area. These results suggest that inhibition of the activity in the gamma pathway descending from the mesencephalic reticular formation may be involved in the mechanism of muscle relaxant action of tolperisone.

  2. 尼麦角林联合盐酸多奈哌齐治疗轻度血管性痴呆的临床疗效及对患者认知功能的影响%The clinical efficacy of nicergoline combined with donepezil hydrochloride in the treatment of mild vascular dementia and its influence on cognitive function

    Institute of Scientific and Technical Information of China (English)

    马淑媛; 白易欣

    2015-01-01

    目的:探讨尼麦角林联合盐酸多奈哌齐治疗轻度血管性痴呆的临床疗效及对患者认知功能的影响。方法将66例轻度血管性痴呆患者采用随机数字表法分为两组,每组33例。在常规综合对症治疗的基础上,对照组给予尼麦角林口服,观察组给予给予尼麦角林联合盐酸多奈哌齐片口服。两组均4周为1个疗程,连续治疗3个疗程。结果治疗后观察组简易智力状况检查表评分为(36.7±5.7)分,较治疗前和对照组均显著升高(t =10.137、11.236,均 P <0.05);观察组 ADL 评分为(35.8±16.2)分,较治疗前和对照组显著降低(t =10.825、11.415,均 P <0.05);观察组总有效率为78.9%,明显高于对照组的54.5%(χ2=9.24, P <0.05)。结论尼麦角林联合盐酸多奈哌齐治疗轻度血管性痴呆,能够明显提高认知功能量表评分,疗效显著,安全可靠。%Objective To investigate the clinical efficacy of nicergoline combined with donepezil hydrochlo-ride in the treatment of mild vascular dementia and its influence on cognitive function.Methods 66 patients with mild vascular dementia from neurology were divided into two groups by random numbers,33 cases in each group.On the based of the routine symptomatic treatment,the control group were given nicergoline,the observation group were treated with nicergoline combined with aricept.Four weeks was a course,both groups were continuously treated for 3 courses.Results The MMSE scores of the observation group after treatment was (36.7 ±5.7)points,which was significantly increased compared with before treatment(t =10.137,P <0.05)and the control group(t =11.236,P <0.05);The ADL score was(35.8 ±16.2)points,which was significantly lower compared with before treatment(t =10.825,P <0.05)and the control group(t =11.415,P <0.05);The total effective rate of the observation group was 78.9%,which was higher than 54

  3. Clinical study on combined application of ambroxol hydrochloride injection and phentolamine injection in the treatment of severe pneumonia in children%盐酸氨溴索注射液与酚妥拉明注射液联合应用于小儿重症肺炎治疗的临床研究

    Institute of Scientific and Technical Information of China (English)

    张久贵; 吴丽

    2015-01-01

    目的:探讨盐酸氨溴索注射液与酚妥拉明注射液联合应用于小儿重症肺炎治疗的临床研究。方法108例重症肺炎患儿随机分为两组,给予全部患儿常规对症治疗,如吸氧、退热、抗感染、抗病毒、镇静、止咳平喘等,同时给予研究组患者静脉滴注盐酸氨溴索及酚妥拉明注射液,对比分析两组疗效、主要症状改善时间、主要指标变化情况。结果两组治疗后总有效率研究组92.59%显著高于对照组70.37%(P <0.05);研究组退热、湿罗音消失、心衰消除、平喘、住院时间均显著低于对照组(P <0.05);两组治疗后超敏 C 反应蛋白(hs‐CRP)、降钙素原(PCT )、肿瘤坏死因子‐α(TNF‐α)水平均显著下降(P<0.05),研究组下降程度优于对照组(P<0.05),差异有统计学意义。结论在常规对症治疗基础上,给予重症肺炎患儿氨溴索与酚妥拉明联合治疗,能有效的提高疗效,加快改善临床症状,显著降低炎性反应。%Objective To explore the clinical study of combined application of Ambroxol Hydrochloride Injec‐tion and phentolamine injection in the treatment of severe pneumonia in children .Methods 108 cases of children with severe pneumonia were randomly divided into two groups ,all were given conventional symptomatic treatment ,such as oxygen ,anti infection ,antiviral ,antipyretic ,sedative ,cough and asthma ,and study group were given intravenous infu‐sion of ambroxol hydrochloride and phentolamine injection ,the main symptoms of the contrastive analysis of two groups of curative effect ,improve the changes the main indicators of time .Results the two groups after treatment the total effective rate of study group 92 .59% was significantly higher than the control group 70 .37% (P< 0 .05) ;the study group defervescence ,wet rales disappearance ,failure elimination ,asthma ,hospitalization time were signifi

  4. 盐酸司维拉姆与碳酸钙治疗慢性肾衰竭血液透析的高磷血症的有效性与安全性的meta分析%A meta analysis of sevelamer hydrochloride and calcium carbonate in the treatment of hyperphosphatemia of chronic kidney disease in patients on hemodialysis

    Institute of Scientific and Technical Information of China (English)

    杨斯淼; 于锋

    2014-01-01

    Objective To evaluate the efficacy and safety of sevelamer hydrochloride compared with calcium carbon-ate in the treatment of hyperphosphatemia of chronic kidney disease in patients on hemodialysis. Methods Relevant random-ized controlled trials( RCTs)were searched from Cochrane library,Pubmed and CNKI. Then traced the related references and experts about RCTs of sevelamer hydrochloride compared with calcium carbonate. The quality of these included studies were e-valuated and the data was analyzed by Cochrane Collaboration's RevNan 5. 0 software. Results 11 RCTs were included. Neta analysis results suggested that compared with calcium carbonate,sevelamer hydrochloride had no statistically significant benefit in concentration of serum phosphate(WND=0. 04,95%CI:-0. 34,0. 42,P=0. 83)and serum calcium(WND= -1. 10, 95%CI:-2. 75,0. 54,P =0. 19 )after treatment. But it had a statistically significant benefit in concentration of iPTH ( WND=0. 84,95%CI:0. 05,1. 62,P=0. 04)after treatment. There was no statistically significant benefit in all-case mortali-ty(WND=0. 54,95%CI:0. 21,1. 38,P=0. 20). Conclusion Compared with calcium carbonate ,sevelamer hydrochloride is more effective for reducing blood phosphorus,and has the similar efficiency and safety and can better control the level of iPTH, which is worthy of clinical use.%目的:系统评价盐酸司维拉姆与传统磷结合剂碳酸钙治疗高磷血症的临床疗效和安全性。方法计算机检索中国学术期刊全文数据库( CNKI)、Pubmed及The Cochrane Library 等数据库,纳入盐酸司维拉姆与碳酸钙的随机对照试验。经过评价纳入研究的质量并提取资料后,应用RevNan 5.0软件进行系统分析。结果共纳入11篇有关盐酸司维拉姆的随机对照试验的研究。经meta分析,结果显示:盐酸司维拉姆与碳酸钙相比,治疗后的血磷水平(WND=0.04,95%CI:-0.34,0.42,P=0.83)及血钙水平(WND=-1.10,95%CI:-2.75,0

  5. Neuroprotective effect of penehyclidine hydrochloride on focal cerebral ischemiareperfusion injury

    Institute of Scientific and Technical Information of China (English)

    Cuicui Yu; Junke Wang

    2013-01-01

    Penehyclidine hydrochloride can promote microcirculation and reduce vascular permeability. However, the role of penehyclidine hydrochloride in cerebral ischemia-reperfusion injury remains unclear. In this study, in vivo middle cerebral artery occlusion models were established in experimental rats, and penehyclidine hydrochloride pretreatment was given via intravenous injection prior to model establishment. Tetrazolium chloride, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling and immunohistochemical staining showed that, penehyclidine hydrochloride pretreatment markedly attenuated neuronal histopathological changes in the cortex, hippocampus and striatum, reduced infarction size, increased the expression level of Bcl-2, decreased the expression level of caspase-3, and inhibited neuronal apoptosis in rats with cerebral ischemia-reperfusion injury. Xanthine oxidase and thiobarbituric acid chromogenic results showed that penehyclidine hydrochloride upregulated the activity of superoxide dismutase and downregulated the concentration of malondialdehyde in the ischemic cerebral cortex and hippocampus, as well as reduced the concentration of extracellular excitatory amino acids in rats with cerebral ischemia-reperfusion injury. In addition, penehyclidine hydrochloride inhibited the expression level of the NR1 subunit in hippocampal nerve cells in vitro following oxygen-glucose deprivation, as detected by PCR. Experimental findings indicate that penehyclidine hydrochloride attenuates neuronal apoptosis and oxidative stress injury after focal cerebral ischemia-reperfusion, thus exerting a neuroprotective effect.

  6. Identification of polymorphism in ethylone hydrochloride: synthesis and characterization.

    Science.gov (United States)

    Maheux, Chad R; Alarcon, Idralyn Q; Copeland, Catherine R; Cameron, T Stanley; Linden, Anthony; Grossert, J Stuart

    2016-08-01

    Ethylone, a synthetic cathinone with psychoactive properties, is a designer drug which has appeared on the recreational drug market in recent years. Since 2012, illicit shipments of ethylone hydrochloride have been intercepted with increasing frequency at the Canadian border. Analysis has revealed that ethylone hydrochloride exists as two distinct polymorphs. In addition, several minor impurities were detected in some seized exhibits. In this study, the two conformational polymorphs of ethylone hydrochloride have been synthesized and fully characterized by FTIR, FT-Raman, powder XRD, GC-MS, ESI-MS/MS and NMR ((13) C CPMAS, (1) H, (13) C). The two polymorphs can be distinguished by vibrational spectroscopy, solid-state nuclear magnetic resonance spectroscopy and X-ray diffraction. The FTIR data are applied to the identification of both polymorphs of ethylone hydrochloride (mixed with methylone hydrochloride) in a laboratory submission labelled as 'Ocean Snow Ultra'. The data presented in this study will assist forensic scientists in the differentiation of the two ethylone hydrochloride polymorphs. This report, alongside our recent article on the single crystal X-ray structure of a second polymorph of this synthetic cathinone, is the first to confirm polymorphism in ethylone hydrochloride. © 2015 Canada Border Services Agency. Drug Testing and Analysis published by John Wiley & Sons, Ltd. © 2015 Canada Border Services Agency. Drug Testing and Analysis published by John Wiley & Sons, Ltd.

  7. 盐酸氨溴索联合氨茶碱治疗小儿支气管哮喘的效果及对肺功能的影响%Effect of ambroxol hydrochloride combined with aminophylline in treatment of infantile bronchial asthma and its effect on pulmonary function

    Institute of Scientific and Technical Information of China (English)

    彭思萃; 吴建谷

    2016-01-01

    Objective To explore the clinical effect of ambroxol hydrochloride combined with aminophylline in treatment of infantile bronchial asthma and its effect on pulmonary function. Methods 132 patients with infantile bronchial asthma who were admitted to our hospital from March 2013 to March 2015 were selected and they were allocated to the control group and the observation group according to the chronological order of admission. Children in two groups were all received routine treatment of bronchial asthma including oxygen inhalation, anti-infection and hormone. Children in the control group were received aminophylline to treat bronchial asthma while children in the observation group were received ambroxol hydrochloride combined with aminophylline to treat bronchial asthma. After treatment, clinical curative effects of children in two groups were compared. Pulmonary function before and after treatment of children in two groups were also compared. Results Total effective rate of bronchial asthma treatment of children in the observation group was 90.6%, significantly higher than that of the control group 76.7%and the difference was statistically significant(P<0.05). After the treatment, pulmonary function of children in two groups were all improved compared with that before treatment(P < 0.05). After treatment, the pulmonary function index of children in the observation group was better than that of children in the control group and the difference was statistically significant (P<0.05). Conclusion Ambroxol hydrochloride combined with aminophylline in treatment of infantile bronchial asthma has better clinical effect and it can effectively improve clinical symptoms and pulmonary function. In addition, it is safe and effective, worthy of clinical application.%目的:探究盐酸氨溴索联合氨茶碱对治疗小儿支气管哮喘的临床疗效及对肺功能的影响。方法选取我院2013年3月~2015年3月收治的小儿支气管哮喘共132例,按照入院

  8. 多巴丝肼片联合盐酸司来吉兰治疗帕金森病患者的疗效和安全性%Analysis of Clinical effect and Safety of Madopar Combined with Selegiline Hydrochloride in the Treatment of Parkinson's disease

    Institute of Scientific and Technical Information of China (English)

    凌征梅

    2016-01-01

    Objective To observe and analyze the effectiveness and safety of madopar combined with selegiline hydrochloride in the treatment of Parkinson's disease(PD).Methods 70 patients with Parkinson's disease and who accepted treatments in our hospital fromMay,2014 toMay,2015 were selected, and were divided into the observation group of 35 cases and the control group of 35 cases by the two color random grouping method. In the control group,they were treated with madopar while in the observation group, they were treated with the madopar combined with selegilinehydrochloride.Then,the clinical efect of two groups of patients were observed.Results The total efective rate in the observation group was 80%, which was higher than that in the control group of 60%(P0.05).Conclusion The clinical effects of madopar combined with selegiline hydrochloride in the treatment of Parkinson's disease are exactly, which can effectively relieve clinical symptoms, reduce patient's discomfort, and the adverse reactions is little, the safety is high,and it can be used as the treatment of choice for Parkinson's disease treatment method, thus it is worth to be applied in the clinical.%目的:探讨多巴丝肼片联合盐酸司来吉兰治疗帕金森病(PD)患者的有效性和安全性。方法选取2014年5月至2015年5月梅州市中医医院收治的PD患者70例为研究对象,按随机数字表法分为观察组和对照组,每组35例。对照组患者采用多巴丝肼片治疗,观察组患者采用多巴丝肼片联合盐酸司来吉兰治疗,观察两组患者临床治疗效果。结果观察组患者治疗总有效率为80.0%,高于对照组的60.0%,差异有统计学意义(P<0.05);观察组患者的精神状态、运动功能、日常活动等帕金森统一评分量表评分均优于对照组,差异均有统计学意义(均P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用多巴丝肼片联合盐

  9. Clinical efficacy and safety of atomoxetine hydrochloride in the treatment of attention deficit hyperactivity disorder with transient tic disorder%盐酸托莫西汀治疗儿童多动症合并短暂性抽动障碍的临床疗效及安全性评价

    Institute of Scientific and Technical Information of China (English)

    方拴锋; 朱晓华; 叶蓓; 陈静; 和慧丽

    2016-01-01

    Objective To evaluate the clinical efficacy and safety of atomoxetine on attention deficit hyperactivity disorder ( ADHD ) children with transient tic disorder.Methods Sixty children of ADHD combined with transient tic disorder were randomly divided into control group ( n=30 ) and treatment group ( n=30 ) .Control group was treated with hydrochloric acid 10 mg, once a day.Treatment group was treated with atomoxetine hydrochloride 0.5 mg・ kg-1 , qd, day 1-7, after 7 days, increase the dose to 1.2 mg・ kg -1 , but the maximum dose should not exceed 1.4 mg・ kg-1 . Two groups of children were treated for 2 months.The clinical efficacy, attention deficit ( AD) , hyperactivity im-pulse ( HI ) , ADHD score and the incidence of adverse drug reactions were compared between two groups.Results After treatment, the total effective rates of ADHD symptoms and transient tic disorder in treatment group were significantly higher than those of control group ( 83.33% vs 76.67%, 80.00%vs 53.33%, P0.05).Conclusion Atomoxetine hydrochloride has a definitive clinical efficacy for the treatment of ADHD combined with transient tic disorder, without increasing of the incidence of adverse drug reactions.%目的:评价盐酸托莫西汀治疗儿童多动症合并短暂性抽动障碍的临床疗效和安全性。方法将60例多动症合并短暂性抽动障碍的患儿随机分为对照组30例和试验组30例。对照组予以盐酸哌甲酯10 mg,qd;试验组予以盐酸托莫西汀0.5 mg・ kg-1,qd,第1~7天,7 d后,增加剂量到1.2 mg・ kg-1,但最大剂量不得超过1.4 mg・ kg-1。2组患儿均连续服药2个月。比较2组患儿的临床疗效、治疗前后注意缺陷(AD)、多动冲动(HI)、注意缺陷多动障碍(ADHD)的评分和不良反应发生率。结果治疗后,试验组ADHD和短暂性抽动障碍的总有效率显著高于对照组(83.33%vs 76.67%,80.00% vs 53.33%,P<0.05

  10. 芬太尼透皮贴剂与盐酸羟考酮缓释片治疗中重度癌痛疗效和安全性的Meta分析%Meta-analysis of Curative Effect and Safety of Transdermal Fentanyl and Oxycodone Hydrochloride Sustained-release Tablets in the Treatment of Moderate and Severe Cancer Pain

    Institute of Scientific and Technical Information of China (English)

    刘思; 余正; 胡霞

    2015-01-01

    Objective: To evaluate the curative effect and safety of transdermal fentanyl and oxycodone hy-drochloride sustained-release tablets in the treatment of moderate and severe cancer pain . Methods: Based on the literature review from CNKI and Wanfang database and med . Wanfang data , literature and information were ex-tracted according to certain inclusion and exclusion criteria. Data was analyzed using RevMan 5.3 software. Results:A total of 4 research papers involved 635 cases were included . The results of meta-analysis showed that the inci-dence of pain remission was not significantly different between the two groups using transdermal fentanyl and oxy-codone hydrochloride sustained-release tablets [ RR=0 . 99 , 95%CI ( 0 . 94 , 1 . 04 ) , P=0 . 72 ] . No significant difference was found between the two groups in the incidence of constipation [ RR=0 . 83 , 95%CI ( 0 . 53 , 1 . 28 ) , P=0 . 39 ] , dizzi-ness [ RR=0 . 85 , 95%CI ( 0 . 46 , 1 . 57 ) , P=0 . 61 ] , somnolence [ RR=0 . 49 , 95%CI ( 0 . 22 , 1 . 06 ) , P=0 . 07 ] , urinary reten-tion [ RR=0 . 53 , 95%CI ( 0 . 15 , 1 . 89 ) , P=0 . 33 ] and mental disorder [ RR=0 . 72 , 95%CI ( 0 . 29 , 1 . 78 ) , P=0 . 47 ] , except the incidence of nausea and vomitting [ RR=0 . 45 , 95%CI ( 0 . 26 , 0 . 76 ) , P=0 . 003 ] , with incidence of 6 . 03%( 17/282 ) and 11 . 33%( 40/353 ) respectively . Conclusion: Transdermal fentanyl and oxycodone hydrochloride sustained-release tablets had similar efficacy in the treatment of moderate and severe cancer pain . The incidence of nausea and vomit-ing caused by transdermal fentanyl was lower than oxycodone hydrochloride sustained-release tablets but the safety of the two drugs are similar .%目的:评价芬太尼透皮贴剂和盐酸羟考酮缓释片治疗中重度癌痛的临床疗效和安全性。方法:检索CNKI、万方数据库和万方医学网获得相关文献,按照一定的纳入和排除标准筛选文献并提取信息,采用RevMan 5.3软件进

  11. Capillary electrophoresis coupled with electrochemiluminescence for determination of cloperastine hydrochloride

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Objective To investigate the electrochemiluminescence (ECL) behavior of cloperastine hydrochloride. Methods ECL intensity of tris (2,2′-bipyridyl) rutheniumo(Ⅱ) was enhanced, the method for the determination of cloperastine hydrochloride was established using capillary electrophoresis (CE) coupled with electrochemilumolinescence (ECL) detection. Results Under the optimum conditions, ECL intensity varied linearly with cloperastine hydrochloride concentration from 7.0×10-6g/mL to 1.0×10-4g/mL. The detection l...

  12. COMPARISON OF DROTAVERINE HYDROCHLORIDE AND VALETHAMATE BROMIDE ON CERVICAL DILATATION

    Directory of Open Access Journals (Sweden)

    Mallika Selvaraj

    2016-06-01

    Full Text Available AIM To compare the two drugs drotaverine hydrochloride and valethamate bromide and their effects on cervical dilatation and labour duration. METHODOLOGY It is a prospective study undertaken at Government Rajaji Hospital on 150 randomly selected primigravidae patients. RESULTS The duration of active phase of first stage of labour was significantly reduced (p value 0.003, rate of cervical dilatation was higher (p value 0.0001 with drotaverine hydrochloride. CONCLUSION Drotaverine hydrochloride is a safe, potent and effective drug to be used in the active phase of labour.

  13. Clinical effect of sensory integration training combined with methylphenidate hydrochloride in the treatment of children with attention deficit hyperac-tivity disorder%感觉统合训练联合盐酸哌甲酯治疗儿童注意缺陷多动障碍的临床效果

    Institute of Scientific and Technical Information of China (English)

    吕园园; 朱锦烨; 徐杰

    2016-01-01

    目的:探讨感觉统合训练联合盐酸哌甲酯治疗儿童注意缺陷多动障碍的临床疗效。方法选取本院2012年8月~2014年7月诊治的122例注意缺陷多动障碍患儿作为研究对象,随机分为对照组和观察组,各61例。对照组采用盐酸哌甲酯治疗,观察组采用感觉统合训练联合盐酸哌甲酯治疗,比较两组的临床疗效。结果两组治疗后的Conner行为评定量表评分显著低于治疗前,差异有统计学意义(P﹤0.05)。观察组治疗后的Conner行为评定量表评分显著低于对照组,差异有统计学意义(P﹤0.05)。两组治疗后的韦氏儿童智力量表评分、视听连续整合测试评分、感觉统合能力发展评定量表评分显著高于治疗前,差异有统计学意义(P﹤0.05)。观察组治疗后的韦氏儿童智力量表评分、视听连续整合测试评分、感觉统合能力发展评定量表评分显著高于对照组,差异有统计学意义(P﹤0.05)。观察组的治疗总有效率为98.4%,显著高于对照组的88.5%,差异有统计学意义(P﹤0.05)。两组的不良反应发生率比较,差异无统计学意义(P﹥0.05)。结论感觉统合训练联合盐酸哌甲酯是临床治疗儿童注意缺陷多动障碍的有效方法,可明显改善患儿病症,疗效显著。%Objective To explore the clinical effect of sensory integration training combined with methylphenidate hy-drochloride in the treatment of children with attention deficit hyperactivity disorder.Methods 122 children with atten-tion deficit hyperactivity disorder in our hospital from August 2012 to July 2014 were selected and randomly divided into the control group and the observation group,61 cases in each group.The control group was given methylphenidate hydrochloride,and the observation group was given sensory integration training combined with methylphenidate hy-drochloride.The clinical effect in the two groups was compared.Results The score of Conner

  14. 盐酸伐昔洛韦与复方甘草酸苷片联合治疗初发性生殖器疱疹临床观察%Clinical Treatment Observation of Valaciclovir Hydrochloride Combined With Compound Glycyrrhizin Tablets in Primary Genital Herpes

    Institute of Scientific and Technical Information of China (English)

    王艳

    2016-01-01

    Objective Hydrochloride on cutting famciclovir combined with compound glycyrrhizic acid glucoside tablets in the treatment of early send sexual genital bleb clinical effect.Methods 86 cases of primary genital herpes patients were divided into study group (HCl valaciclovir+ compound licorice tablets) and control group (valaciclovir).ResultsThe total effective rate of the study group was higher than that of the control group (P0.05).Conclusion Hydrochloric acid cutting famciclovir combined with compound glycyrrhizic acid glucoside tablets in the treatment of early send sexual genital bleb has a good clinical effect.%目的:探讨盐酸伐昔洛韦联合复方甘草酸苷片治疗初发性生殖器疱疹的临床效果。方法将86例初发性生殖器疱疹患者分为研究组(盐酸伐昔洛韦+复方甘草酸苷片)和对照组(盐酸伐昔洛韦)。结果研究组总有效率高于对照组(P<0.05);复发率低于对照组(P<0.05);两组不良反应发生率无统计学差异(P>0.05)。结论盐酸伐昔洛韦联合复方甘草酸苷片治疗初发性生殖器疱疹有较好临床效果。

  15. Premilinary Observation of Sarpogrelate Hydrochloride on Prevention and Treatment for Gluteal and Limb Ischemia Following Endovascular Repair of Abdominal Aortic Aneurysm%盐酸沙格雷酯在腹主动脉瘤腔内修复术后防治臀肌和下肢缺血的初步观察

    Institute of Scientific and Technical Information of China (English)

    黄斌; 赵纪春; 马玉奎; 卢武胜; 杨轶; 袁丁

    2012-01-01

    Objective To observe the effects of sarpogrelate hydrochloride in prevention and treatment for ischemia of gluteal and limb following endovascular repair of abdominal aortic aneurysm (EVAR) . Methods Clinical data were analyzed in 174 patients with abdominal aortic aneurysm (AAA) who underwent EVAR from January 2006 to January 2011. The patients' mean age was (71. 8 + 8. 2) years old (male: 148 cases, female: 26 cases) . The diameter of abdominal aortic aneurysm was (55. 2+12. 9) mm. AAA involving common iliac artery was in 52 (29.9%) patients. Bifurcated endografts and aorto-uni-iliac (AUI) endografts with crossover bypass were used in 169 patients (97. 1%) and 5 patients (2. 9%) , respectively. Sarpogrelate hydrochloride were used in 39 patients with gluteal and limb ischemia due to exclusion of bilateral and unilateral internal iliac arteries among 174 patients. Sarpogrelate hydrochloride, 100 mg, three times daily, was taken for 2-4 weeks. Symptoms of gluteal and limb ischemia were followed-up. Results All of patients with AAA was repaired by EVAR successfully and no conversion to open repair. General anesthesia (50. 6% (88/174)], epidural anesthesia (30. 0% (52/174)], and local anesthesia (19. 5% (34/174)] were used. Blood loss was (125. 2+43. 1) ml and no blood transfusion during operation. Operative time was (145. 5 + 38. 7) min, ICU stay time was (14. 7+5. 2) h, and postoperative fasting time was (7. 2+4. 3) h. The duration of postoperative hos-pital stay was (9. 1 ±2. 7) d. The perioperative complication rate was 12. 6% (22/174) . The 30-day mortality rate was 1. 1% (2/174) . Gluteal and limb claudication occurred in 2 paients and 5 patients respectively among 29 patients with EVAR due to exclusion of unilateral internal iliac artery, intermittent claudication distance was 100-200 meters. Gluteal muscle pain and limb claudication for less than 200 meters occurred in 4 patients due to exclusion of bilateral internal iliac artery. The symptoms were relieved

  16. Prednisone and vardenafil hydrochloride for refractory levamisole-induced vasculitis.

    Science.gov (United States)

    Mandrell, Joshua; Kranc, Christina L

    2016-08-01

    Levamisole is an immunomodulatory drug that was previously used to treat various medical conditions, including parasitic infections, nephrotic syndrome, and colorectal cancer. Over the last few years, increasing amounts of levamisole have been used as an adulterant in cocaine. Levamisole-cut cocaine has become a concern because it is known to cause a necrotizing purpuric rash, autoantibody production, and life-threatening leukopenia. Mixed histologic findings of vasculitis and thrombosis are characteristic of levamisole-induced purpura. The recommended management of levamisole-induced vasculitis currently involves withdrawal of the culprit along with supportive treatment. We describe a patient with levamisole-induced vasculitis who continued to develop skin lesions despite self-reported cocaine cessation. Complete resolution of cutaneous disease occurred with the addition of oral prednisone and vardenafil hydrochloride, suggesting the possibility of a new treatment option in patients with refractory disease. In addition, we review the clinical presentation, disease course, diagnostic approach, laboratory findings, histology, and management of levamisole-induced vasculitis. The harmful effects of levamisole-cut cocaine are serious enough that public alerts have been issued to increase awareness. Clinicians should consider the possibility of levamisole exposure in cocaine users presenting with any combination of fever, neutropenia, and necrotic skin lesions, especially in acral areas including the ears.

  17. A novel formulation for mebeverine hydrochloride.

    Science.gov (United States)

    Abdel-Hamid, Sameh M; Abdel-Hady, Seham E; El-Shamy, Abdel-Hamid A; El-Dessouky, Hadir F

    2007-10-01

    The antispasmodic drug mebeverine hydrochloride was formulated into a film-forming gel to be used as a topical local anesthetic. A mixture of cellulose derivatives was used as a base. Additives were used to enhance the release as well as the residence time. Formulations were characterized in terms of drug release, mucoadhesion and rheology. Clinically, the selected formula has shown faster onset (p = 0.0156), longer duration (p = 0.0313), better film residence (p = 0.0313), and no foreign body sensation (p = 0.0313) in comparison to Solcoseryl dental paste. Histopathological examination showed no change in inflammatory cells count, concluding that this topical anesthetic is efficacious and safe orally.

  18. "Sustained release formulation of Metoclopramide Hydrochloride "

    Directory of Open Access Journals (Sweden)

    Dabbagh MA

    2000-08-01

    Full Text Available In this research, several formulations containing, an anti emetic agent (Metoclopramide hydrochloride, a hydrophilic polymer (hydroxypropylmethylcellulose and a hydrophobic polymer (ethylcellulose 10 cP were prepared by direct compression. Different factors such as: the effect of different ratios of the polymers, particle size, pressure force and differences of release in acidic and distilled water as media were investigated. After developing the ideal formulation, the effect of changing the ratio of drug in core: coating on the formulation was investigated. Coating of tablets with ethylcellulose, changed the release mechanism of drug and shifted it to near zero order release. The results showed that except when matrices were coated with ethylcellulose, drug release was proportioned to the square root of time, which might be due to the change of release pattern from matrix to reservoir system.

  19. Dyeing Characteristics of Chitosan Biguanidine Hydrochloride Treated Wool Fabrics

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xue; HE JIN-xin

    2010-01-01

    @@ Chitosan biguanidine hydrochloride(CGH)has been synthesized by the guanidineylation reaction of chitosan with dicyandiamide.The structures of CGH were characterized by Fourier transform infrared spectroscopy and 13CNMR spectra.

  20. Antifungal activity of hydrochloride salts of tylophorinidine and tylophorinine.

    Science.gov (United States)

    Dhiman, Mini; Parab, Rajashri R; Manju, Sreedharannair L; Desai, Dattatraya C; Mahajan, Girish B

    2012-09-01

    The antimicrobial efficacy of two phenanthroindolizidine alkaloids, tylophorinidine hydrochloride (TdnH) and tylophorinine hydrochloride (TnnH), isolated from the plant Tylophora indica (local name, Antamul) was evaluated. These were screened for in vitro antifungal and antibacterial activities. Both compounds exhibited potent antifungal activity displaying minimum inhibitory concentrations (MIC) in the range of 2-4 microg/mL for TdnH and 0.6-2.5 microg/mL for TnnH against Candida species.

  1. COMPARISON OF DROTAVERINE HYDROCHLORIDE AND VALETHAMATE BROMIDE ON CERVICAL DILATATION

    OpenAIRE

    Mallika Selvaraj; Sumathi

    2016-01-01

    AIM To compare the two drugs drotaverine hydrochloride and valethamate bromide and their effects on cervical dilatation and labour duration. METHODOLOGY It is a prospective study undertaken at Government Rajaji Hospital on 150 randomly selected primigravidae patients. RESULTS The duration of active phase of first stage of labour was significantly reduced (p value 0.003), rate of cervical dilatation was higher (p value 0.0001) with drotaverine hydrochloride. CONCLUS...

  2. Simultaneous Spectrophotometric Determination of Drotaverine Hydrochloride and Paracetamol in Tablet

    OpenAIRE

    Mahaparale Sonali; Telekone R; Raut R; Damle S; Kasture P

    2010-01-01

    Two simple, accurate and reproducible spectrophotometric methods; Q analysis and first order derivative method have been described for the simultaneous estimation of drotaverine hydrochloride and paracetamol in combined tablet dosage form. Absorption maxima of drotaverine hydrochloride and paracetamol in distilled water were found to be 303.5 nm and 243.5 nm respectively. Beer′s law was obeyed in the concentration range 5-50 µg/ml for drotaverine and 5-60 µg/ml for paracetamo...

  3. [Efficacy of Betahistine Mesilate combined with Flunarizine Hydrochloride for treating tinnitus].

    Science.gov (United States)

    Ma, Fu-rong; Xin, Ying; Zhao, Yi-ming; Lü, Jing-qiao

    2006-04-01

    To determine whether Betahistine mesilate is effective in treating tinnitus. Randomized, prospective, double-blind, controlled trial was used in our study. The study group consisted of 60 adult patients who consulted our outpatient clinic complaining of subjective tinnitus, excluded objective tinnitus and the patients who had tinnitus caused by obvious diseases, such as outer and middle ear diseases. Thirty patients were given Betahistine mesilate and Flunarizine Hydrochloride as an experimental group, 30 patients were given Vitamin B6 and Flunarizine Hydrochloride as a control group. After a week of treatment the efficacy of the medicines in two groups was observed. Tinnitus questionnaire was performed before the treatment, and pure tone audiogram, tinnitus pitch and loudness matching were performed both in the beginning and at the end of the treatment. Completion of treatment, tinnitus loudness matching assessment showed that the efficacy of the Betahistine mesilate group was better then the control group. The efficacy of treatment was respectively 65.5% by per protocol (PP) and 63.3% by intend to treat (ITT) in the Betahistine mesilate group and 39.3% by PP and 36.7% by ITT in the control group. The difference of tinnitus loudness improvement rate between the experimental group and control group was statistically significant. But the subjective tinnitus improvement rate showed no difference between two groups. There were not serious side effects in the two groups. Betahistine mesilate can be a choice for tinnitus treatment clinically. Further studies of larger series and placebo-controlled trial are needed.

  4. Effects of changing the type of H2-blocker in the treatment of H2-blocker-resistant ulcers: comparison of roxatidine acetate hydrochloride and other H2-blockers.

    Science.gov (United States)

    Yasutake, K; Amano, M; Mizokami, Y; Kubota, S; Fukumoto, H; Imamura, Y; Yokoya, H; Irie, K

    1998-01-01

    The efficacy of switching from one type of H2-receptor antagonist (H2-blocker) to another, in the treatment of H2-blocker-resistant ulcers was investigated using H2-blockers with five-membered rings (five-membered-ring agents)--such as cimetidine, ranitidine and famotidine--and an H2-blocker with a six-membered ring, roxatidine. By switching from a five-membered-ring agent to roxatidine in the treatment of five-membered-ring resistant ulcers (study I), gastric ulcers were healed in nine of 19 patients (47%) and duodenal ulcers were healed in eight of nine patients (89%). By switching from roxatidine to one of the five-membered-ring agents in the treatment of roxatidine-resistant ulcers (study II), gastric ulcer was healed in six of 15 patients (40%), and duodenal ulcer was healed in 4 of 10 patients (40%). Particularly in the case of duodenal ulcers, the switch to treatment with roxatidine, which has a different chemical structure from the five-membered-ring agents, may be useful in the treatment of five-membered-ring-resistant ulcers.

  5. Simultaneous Estimation of Gemcitabine Hydrochloride and Capecitabine Hydrochloride in Combined Tablet Dosage Form by RP-HPLC Method

    Directory of Open Access Journals (Sweden)

    V. Rajesh

    2011-01-01

    Full Text Available A new reverse phase high performance liquid chromatography (RP-HPLC method has been developed for the simultaneous estimation of gemcitabine hydrochloride and capecitabine hydrochloride in combined tablet dosage form. An inertsil ODS-3 C-18 column having dimensions of 250×4.6 mm and particle size of 5 µm, with mobile phase containing a mixture of acetonitrile : water : triethyelamine in the ratio of (70 : 28 : 2v/v was used. The pH of mobile phase was adjusted to 4.0 with ortho-phosphoric acid. The flow rate was 1 mL/min and the column effluents were monitored at 260 nm. The retention time for gemcitabine hydrochloride and capecitabine hydrochloride was found to be 2.76 and 2.3 min respectively. The proposed method was validated in terms of linearity, accuracy, precision, limit of detection, limit of quantitation and robustness. The method was found to be linear in the range of 10-50 µg/mL and 4-24 µg/mL for gemcitabine hydrochloride and capecitabine hydrochloride, with regression coefficient r = 0.999 and r = 0.999, respectively.

  6. Dyeing Characteristics of Chitosan Biguanidine Hydrochloride Treated Wool Fabrics

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Chitosan biguanidine hydrochloride(CGH) has been synthesized by the guanidineylation reaction of chitosan with dicyandiamide.The structures of CGH were characterized by Fourier transform infrared spectroscopy and 13CNMR spectra.In this paper,we used citric acid(CA) as a crosslinking agent,mixed with CGH to perform a pad-drycure treatment on wool fabric to study reaction mechanism during crosslinking with the help of Fourier transform infrared spectroscopy(FT-IR) and scanning electron microscopy(SEM).Dyeing characteristics of CGH treated wool fabric was assessed.The effects of CGH concentration,curing temperature,dipping time,pH value on color yield of reactive dyes on wool fibres were investigated.Fastness properties of the modified wool fabric to laundering and crocking have also been discussed.Fourier transform infrared spectroscopy(FT-IR) showed that CA produce esterification with the-OH group of the wool and transamidation with the-NH2 group of the CGH to form a crosslink.Scanning electron microscopy(SEM) analysis showed the CGH firmly attached to the surface of wool fibre.It was found that the CGH pretreated wool fabrics had significantly improved dyeability characteristics.It is worthwhile to mention that the CGH treated samples have antibacterial potential due to the antibacterial property of chitosan molecules and guanidinium salts.

  7. Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application

    Directory of Open Access Journals (Sweden)

    Mahmood S

    2014-09-01

    Full Text Available Syed Mahmood, Muhammad Taher, Uttam Kumar Mandal Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM, Pahang Darul Makmur, Malaysia Abstract: Raloxifene hydrochloride, a highly effective drug for the treatment of invasive breast cancer and osteoporosis in post-menopausal women, shows poor oral bioavailability of 2%. The aim of this study was to develop, statistically optimize, and characterize raloxifene hydrochloride-loaded transfersomes for transdermal delivery, in order to overcome the poor bioavailability issue with the drug. A response surface methodology experimental design was applied for the optimization of transfersomes, using Box-Behnken experimental design. Phospholipon® 90G, sodium deoxycholate, and sonication time, each at three levels, were selected as independent variables, while entrapment efficiency, vesicle size, and transdermal flux were identified as dependent variables. The formulation was characterized by surface morphology and shape, particle size, and zeta potential. Ex vivo transdermal flux was determined using a Hanson diffusion cell assembly, with rat skin as a barrier medium. Transfersomes from the optimized formulation were found to have spherical, unilamellar structures, with a ­homogeneous distribution and low polydispersity index (0.08. They had a particle size of 134±9 nM, with an entrapment efficiency of 91.00%±4.90%, and transdermal flux of 6.5±1.1 µg/cm2/hour. Raloxifene hydrochloride-loaded transfersomes proved significantly superior in terms of amount of drug permeated and deposited in the skin, with enhancement ratios of 6.25±1.50 and 9.25±2.40, respectively, when compared with drug-loaded conventional liposomes, and an ethanolic phosphate buffer saline. Differential scanning calorimetry study revealed a greater change in skin structure, compared with a control sample, during the ex vivo drug diffusion study. Further, confocal laser

  8. 氨氯地平联合盐酸贝那普利治疗高血压合并冠心病的临床疗效%Clinical efficacy of amlodipine combining benazepril hydrochloride in treatment of hypertension complicating coronary heart disease

    Institute of Scientific and Technical Information of China (English)

    何屹然

    2015-01-01

    目的:探讨氨氯地平联合盐酸贝那普利治疗高血压合并冠心病的临床疗效。方法选择自2012年4月~2014年4月于北京海淀区蓟门里社区卫生服务中心收治的高血压合并冠心病患者120例。120例患者采用随机数字表法分为研究组和对照组,每组60例。其中,研究组男性37例,女性23例,年龄60~79岁,平均(66.2±5.1)岁。对照组男性35例,女性25例,年龄60~82岁,平均(67.3±6.4)岁。对照组口服硝苯地平缓释片30 mg/d,治疗组口服苯磺酸氨氯地平5 mg/d和盐酸贝那普利10 mg/d,疗程3个月。比较两组患者的心绞痛症状改善情况、血压变化情况、心电图情况及不良反应发生情况。结果与对照组比较,研究组心绞痛症状改善总有效率升高(78.3% vs.91.7%),差异有统计学意义(P<0.05)。与对照组比较,研究组心电图指标改善总有效率升高(70.0% vs.88.3%),差异有显著统计学意义(P<0.01)。两组患者治疗后收缩压和舒张压均较治疗前下降,差异有统计学意义(P均<0.05)。与对照组治疗后比较,研究组收缩压和舒张压降低,为[(134.5±12.7)mmHg vs.(121.0±13.1)mmHg]和[(88.4±7.5)mmHg vs.(79.5±6.4)mmHg](1mmHg=0.133kPa),差异有统计学意义(P均<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论苯磺酸氨氯地平联合盐酸贝那普利治疗高血压合并冠心病,临床疗效确切,副作用少,值得推广。%Objective To investigate the Clinical efficacy of amlodipine combining benazepril hydrochloride in treatment of hypertension complicating coronary heart disease (CHD). Methods The patients with hypertension complicating CHD (n=120) were chosen from Apr. 2012 to Apr. 2014, and divided into study group (n=60, male 37, female 23, aged from 60 to 79 and average age=66.2±5.1), and control group (n=60, male 35, female 25, aged

  9. Clinical Analysis of Ambroxol Hydrochloride in the Treatment of Senile Chronic Bronchitis%盐酸氨溴索治疗老年慢性支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    杨瑄琍

    2016-01-01

    Objective To observe the ambroxol treatment of elderly patients with chronic bronchitis clinical results.Methods January 2014-July 2015 in our hospital respiratory medicine hospitalized elderly patients with chronic bronchitis,86 cases were randomly divided into two groups and the control group 43 cases.The control group received conventional treatment,observation group were treated with ambroxol treatment in the control group, based on the clinical efficacy of the two groups of patients.Results The cure rate and the total effective rate was 55.8%and 97.7%respectively in the control group,the cure rate and the total effective rate was 34.9 and 79.1%respectively.Observation group was significantly higher,the difference was significant( <0.05).Conclusion The conventional treatment with ambroxol treatment of elderly patients with chronic bronchitis significant effect.%目的:观察盐酸氨溴索治疗老年慢性支气管炎的临床效果。方法选择2014年1月~2015年7月我院呼吸内科住院的老年慢性支气管炎患者86例,随机分为观察组和对照组各43例。对照组给予常规治疗,观察组在对照组基础上加用盐酸氨溴索治疗,观察两组患者临床疗效。结果观察组痊愈率和总有效率分别为55.8豫和97.7豫,对照组痊愈率和总有效率分别为34.9和79.1豫。观察组明显高于对照组,差异有显著性(<0.05)。结论采用常规治疗配合盐酸氨溴索治疗老年慢性支气管炎疗效显著。

  10. Efficacy of combination therapy with amlodipine besylate/benazepril hydrochloride for lowering systolic blood pressure in stage 2 hypertension.

    Science.gov (United States)

    Neutel, Joel M; Smith, David H G; Weber, Michael A; Schofield, Lesley; Purkayastha, Das; Gatlin, Marjorie

    2006-01-01

    The Systolic Evaluation of Lotrel Efficacy and Comparative Therapies (SELECT) study compared daily treatment with combination amlodipine besylate/benazepril hydrochloride 5/20 mg, amlodipine besylate 5 mg, and benazepril hydrochloride 20 mg in 505 patients aged 55 years of age or older with stage 2 hypertension (systolic blood pressure [BP] > or =160 and or =60 and < or =100 mm Hg). BP and pulse pressure were assessed by conventional office BP measurements and 24-hour ambulatory BP monitoring. In this analysis, combination therapy was associated with significantly greater reductions in mean 24-hour BP, pulse pressure, and mean ambulatory BP during various time intervals compared with either monotherapy in the intent-to-treat population, in those with isolated and predominantly systolic hypertension, and in dippers and nondippers. Adverse event rates were low and similar in all treatment groups. This study demonstrated that combination therapy is superior to monotherapy in older patients with stage 2 systolic hypertension and is well tolerated.

  11. Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats.

    Science.gov (United States)

    Oliveira, Rita de Cássia Silva de; Brito, Marcus Vinicius Henriques; Ribeiro, Rubens Fernando Gonçalves; Oliveira, Leonam Oliver Durval; Monteiro, Andrew Moraes; Brandão, Fernando Mateus Viegas; Cavalcante, Lainy Carollyne da Costa; Gouveia, Eduardo Henrique Herbster; Henriques, Higor Yuri Bezerra

    2017-03-01

    To evaluate the effects of tramadol hydrochloride associated to remote ischemic perconditioning on oxidative stress. Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Tramadol group (T) treated with tramadol hydrochloride (40mg/kg); remote ischemic perconditioning + Tramadol group (Per+T) with both treatments. Oxidative stress was assessed after 24 hours of reperfusion. Statistical differences were observed in MDA levels between I/R group with all groups (pTramadol with Sham, Per and Per+T groups (ptramadol or association of both treatments.

  12. Maintenance of response after open-label treatment with atomoxetine hydrochloride in international European and non-European adult outpatients with attention-deficit/hyperactivity disorder: a placebo-controlled, randomised withdrawal study

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    Himanshu Upadhyaya

    2013-09-01

    Full Text Available Background and Objectives: We evaluated maintenance of response to atomoxetine during a 25-week, double-blind, placebo-controlled, randomised withdrawal period in adults with attention-deficit/hyperactivity disorder (ADHD who previously responded to atomoxetine during a 12 week open-label treatment period and maintained that response during a 12-week double-blind maintenance period. Methods: Patients (N = 2017, 18 to 50 years of age, diagnosed with ADHD from 152 outpatient sites in 18 countries received 12 weeks of open-label atomoxetine (40-100 mg/day followed by 12 weeks of double-blind maintenance (80 or 100 mg/day. Responders were randomized to atomoxetine (N = 266 or placebo (N = 258 for 25-weeks of double-blind treatment. The percentage of patients with a reduction >30% in their baseline Conners' ADHD Rating Scale Investigator-Rated: Screening Version (CAARS-Inv:SV total score and a score of <3 on the Clinical Global Impression ADHD-Severity (CGI-ADHD-S after 25 weeks was compared between treatment groups with a Fisher's exact test. Mean changes from baseline in the CAARS-Inv:SV and Adult Attention-Deficit/Hyperactivity Disorder Quality of Life (AAQoL were analysed. Results: Most patients enrolled (60% were from Europe. More atomoxetine- than placebo-treated patients maintained a satisfactory response postrandomisation (64.3% vs. 50.0%; p < .001. Time-to-relapse was significantly longer for atomoxetine than placebo (p = .004. Atomoxetine maintained greater improvements in ADHD symptoms compared with placebo (LS mean worsening in the CAARS-Inv:SV total score was 0.9 vs. 4.8 [ p < .001 ] and in the CGI-ADHD-S rating was 0.0 vs. 0.5 [ p < .001 ]. These results were supported by self- or observer-rated measures. Lastly, atomoxetine maintained greater improvements in quality of life compared with placebo (AAQoL total score was 0.4 vs. -4.0; p = .002. Conclusions: This study demonstrated that atomoxetine was superior to placebo in maintaining

  13. The Clinical Analysis of Donepezil Hydrochloride in the Treatment of Senile Dementia%盐酸多奈哌齐治疗老年痴呆的临床探析

    Institute of Scientific and Technical Information of China (English)

    祝鸿雁

    2015-01-01

    目的:探讨盐酸多奈哌齐治疗老年痴呆的临床探析。方法选取2013年11月到2014年12月我院接诊的42例老年痴呆患者,随机分为两组,实验组22例和对照组20例,对照组给予常规治疗,实验组在对照组的基础上给予盐酸多奈哌齐,观察两组患者的治疗效果。结果实验组患者的简易智能精神状态检查量表(MMSE)评分、日常生活能力量表(ADL)评分及不良反应的发生率明显优于对照组,差异显著,有统计学意义(P<0.05)。结论盐酸多奈哌齐治疗老年痴呆的效果显著,有效改善患者的精神状态,提高患者的日常生活能力,值得临床推广。%Objective To study the clinical analysis of senile dementia on donepezil HCL treatment. Methods To divide the 42 cases patients into control group (22 cases)and experimental group(20 cases). The patients’cases were chosen from November 2013 to December 2014,the control group adopted conventional treatment,the experimental group adopted the basis of the control group combine with donepezil HCL,to observe the two groups’ therapeutic effect. Results The date of experimental group patients from simple intel igence scale for mental state examination score(MMSE),daily life ability scale score(ADL)and the incidence of adverse reaction was better than control group,it was in a high treatment efficiency and obvious difference and the statistical y significant(P< 0.05). Conclusion Donepezil HCL treatment has significantly effectively on the patients' mental state and the ability of the patients' daily life. It is widely used in clinical promotion.

  14. Extended-Release Guaifenesin/Pseudoephedrine Hydrochloride for Symptom Relief in Support of a Wait-and-See Approach for the Treatment of Acute Upper Respiratory Tract Infections: A Randomized, Double-Blind, Placebo-Controlled Study

    Directory of Open Access Journals (Sweden)

    Edward J. Septimus, MD, FIDSA, FACP, FSHEA

    2017-01-01

    Conclusions: The study found that a wait and see approach was associated with decreased antibiotic use. In addition, the use of a guaifenesin pseudoephedrine combination product provided an effective symptom control compared to a placebo and a well-tolerated first-line strategy for the management of URTIs. This study was not designed to assess the effects of guaifenesin or pseudoephedrine individually. Other limitations include the need for better clinical methods to assess the effectiveness of treatments for acute symptoms of patients with URTIs. ClinicalTrials.gov identifier: NCT01202279.

  15. Effects of mu comfortable, ligustrazine hydrochloride injection in adjuvant treatment of elderly community-acquired pneumonia%沐舒坦、盐酸川芎嗪注射液辅助治疗老年社区获得性肺炎的效果评价

    Institute of Scientific and Technical Information of China (English)

    谢东胜

    2012-01-01

    目的 评价沐舒坦、盐酸川芎嗪注射液对老年社区获得性肺炎(CAP)疗效和安全性.方法 将老年CAP106例随机分为治疗组和对照组,每组53例.治疗组沐舒坦、盐酸川芎嗪注射液辅助治疗,对照组常规治疗,比较两组患者的治疗结局、发热、咳嗽、咳痰、气喘、胸闷恢复时间、重症患者的病死率及住院时间的差异,检测治疗组患者的不良反应.结果治疗组重症患者的死亡率明显低于对照组(P<0.01);治疗组患者的发热、咳嗽、咳痰、气喘、胸闷恢复时间均短于对照组(P<0.01);两组患者的住院时间明显短于对照组(P<0.01).治疗组所有患者均未发现明显不良反应.结论 沐舒坦、盐酸川芎嗪注射液辅助治疗老年社区获得性肺炎疗效可靠,安全性好,值得推广.%Objective To evaluate the efficacy and safety of combination of Ambroxol Hydrochloride and Ligustrazine llydrochlo-ride Injection in adjuvant treatment of the elderly patients with Community acquired pneumonia ( CAP ). Methods 106 cases of Elderly patients with CAP were randomly divided into control group and treatment group, each group 53 cases. The control group received routine therapy while the treatment group received adjunctive treatment with combination of Ambroxol llydrochloride and Ligustrazine llydrochlo-ride Injection based on routine therapy. Treatment outcome, recovery time of Symptoms, mortality in critically ill patients and length of Hospital Stay were compared between the two groups and adverse reactions of treatment group were observed. Results The mortality in critically ill patients of treatment group was significantly lower than that of control group ( P < 0. 01 ). The recovery time of Symptoms such as Fever, cough, expectoration, wheezing, chest tightness and the length of Hospital Stay were significantly shorter than those of control group ( P <(). 01 ). There was no significant adverse effects in treatment group

  16. Stability of cefozopran hydrochloride in aqueous solutions.

    Science.gov (United States)

    Zalewski, Przemysław; Skibiński, Robert; Paczkowska, Magdalena; Garbacki, Piotr; Talaczyńska, Alicja; Cielecka-Piontek, Judyta; Jelińska, Anna

    2016-01-01

    The influence of pH on the stability of cefozopran hydrochloride (CZH) was investigated in the pH range of 0.44-13.00. Six degradation products were identified with a hybrid ESI-Q-TOF mass spectrometer. The degradation of CZH as a result of hydrolysis was a pseudo-first-order reaction. As general acid-base hydrolysis of CZH was not occurred in the solutions of hydrochloric acid, sodium hydroxide, acetate, borate and phosphate buffers, kobs = kpH because specific acid-base catalysis was observed. Specific acid-base catalysis of CZH consisted of the following reactions: hydrolysis of CZH catalyzed by hydrogen ions (kH+), hydrolysis of dications (k1H2O), monocations (k2H2O) and zwitter ions (k3H2O) and hydrolysis of zwitter ions (k1OH-) and monoanions (k2OH-) of CZH catalyzed by hydroxide ions. The total rate of the reaction was equal to the sum of partial reactions: [Formula: see text]. CZH similarly like other fourth generation cephalosporin was most stable at slightly acidic and neutral pH and less stable in alkaline pH. The cleavage of the β-lactam ring resulting from a nucleophilic attack on the carbonyl carbon in the β-lactam moiety is the preferred degradation pathway of β-lactam antibiotics in aqueous solutions.

  17. Interaction of articaine hydrochloride with prokaryotic membrane lipids.

    Science.gov (United States)

    Lygre, Henning; Moe, Grete; Nerdal, Willy; Holmsen, Holm

    2009-01-01

    Local anesthetics are the most commonly used drugs in dentistry, with a wide range of effects, including antimicrobial activity. High antimicrobial effects have recently been reported on oral microbes from articaine hydrochloride, revealed by the minimum inhibitory concentration and minimal bactericidal concentration. Additionally, articaine has recently been used as an alkaline component in endodontic materials with a proposed antibacterial activity. However, the detailed mechanisms of action have not been discussed. We determined the Langmuir surface pressure/molecular area isotherms of prokaryotic lipid monolayers, as well as the phospholipid phase transitions, by employing differential scanning calorimetry on unilamellar prokaryotic liposomes (bilayers). Articaine hydrochloride was found to interact with the prokaryotic membrane lipids in both monolayers and bilayers. An increase of the phospholipid molecular area of acidic glycerophospholipids as well as a decrease in phase transition temperature and enthalpy were found with increasing articaine hydrochloride concentration. The thermodynamic changes by adding articaine hydrochloride to prokaryotic membrane lipids are potentially related to the effects observed from antimicrobial peptides resulting from membrane insertion, aggregate composition, pore formation, and lysis. Interaction of articaine hydrochloride with prokaryotic membrane lipids is indicated. Hence, further research is necessary to gain insight into where these compounds exert their effects at the molecular level.

  18. Iontophoretic transdermal delivery of buspirone hydrochloride in hairless mouse skin.

    Science.gov (United States)

    Al-Khalili, Mohammad; Meidan, Victor M; Michniak, Bozena B

    2003-01-01

    The transdermal delivery of buspirone hydrochloride across hairless mouse skin and the combined effect of iontophoresis and terpene enhancers were evaluated in vitro using Franz diffusion cells. Iontophoretic delivery was optimized by evaluating the effect of drug concentration, current density, and pH of the vehicle solution. Increasing the current density from 0.05 to 0.1 mA/cm2 resulted in doubling of the iontophoretic flux of buspirone hydrochloride, while increasing drug concentration from 1% to 2% had no effect on flux. Using phosphate buffer to adjust the pH of the drug solution decreased the buspirone hydrochloride iontophoretic flux relative to water solutions. Incorporating buspirone hydrochloride into ethanol:water (50:50 vol/vol) based gel formulations using carboxymethylcellulose and hydroxypropylmethylcellulose had no effect on iontophoretic delivery. Incorporation of three terpene enhancers (menthol, cineole, and terpineol) into the gel resulted in a synergistic effect when combined with iontophoresis. Menthol was the most active enhancer, and when combined with iontophoresis it was possible to deliver 10 mg/cm2/day of buspirone hydrochloride.

  19. Short-term therapeutic effects of combined therapy with metformin hydrochloride for aplastic anemia

    Directory of Open Access Journals (Sweden)

    Xue-chun LU

    2012-03-01

    Full Text Available Objective To screen and select new drugs for aplastic anemia (AA and evaluate their clinical efficacy by clinical bioinformatics methods. Methods First, we established genome expression profiles of AA patients, and conducted similarity analyses with the pharmacogenomics database to screen and select drugs with possible efficacy. Intractable AA patients who received immunosuppressors and/or androgen for more than six months showing no clinical efficacy were enrolled in the study to evaluate therapeutic effects of the therapeutic regime. Clinical efficacy and adverse effects were evaluated after six months. Results The clinical bioinformatics results showed therapeutic effects of metformin hydrochloride on AA. Forty-three intractable AA patients (15 with severe AA were treated with metformin hydrochloride combined with cyclosporin A (CsA and stanozolol. Twenty-seven transfusion-dependent patients (100% became transfusion independent after a 6-month therapy. The hemoglobin level completely returned to normal in 37 out of 40 anemia patients (92.5%. In the 40 patients with platelet count lower than 20×109/L, the platelet count of 28 patients (90.3% increased to higher than 50×109/L. The white cell count increased to higher than 3.5×109/L in 30 out of 35 patients (88.6% with white cell count lower than 2.5×109/L. Among 40 anemic patients, 1 was found to have abnormal renal function, but it recovered to the normal range after ending CsA treatment. Eighteen patients were found to have elevated transaminase levels which were lowered to normal range after using liver protectants and reducing the dosage of stanozolol. There were no instances of hypoglycemia in all patients throughout the treatment. Conclusion Combination of metformin hydrochloride, CsA and stanozolol is effective in refractory aplastic anemia with acceptable toxicity.

  20. Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors

    Directory of Open Access Journals (Sweden)

    Xiao HT

    2012-11-01

    Full Text Available Hong-Tao Xiao,1,* Zhi Liao,2,* Rong-Sheng Tong11Department of Pharmacy, 2Department of Gynecology and Obstetrics, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China*These authors contributed equally to this workBackground: The aim of this review was to evaluate and summarize the available scientific information on penehyclidine hydrochloride (PHC for the treatment of chronic obstructive pulmonary disease (COPD as a result of its ability to attenuate Toll-like receptors. Penehyclidine hydrochloride is an anticholinergic drug manufactured in China, with both antimuscarinic and antinicotinic activity. PHC is used widely in the clinic as a reversal agent in cases of organic phosphorus poisoning and soman poisoning, but also may also have an important role as a bronchodilator in the treatment of obstructive airway disease, including asthma and, in particular, COPD.Methods: Our bibliographic sources included the CAPLUS, MEDLINE, REGISTRY, CASREACT, CHEMLIST, CHEMCATS, and CNKI databases, updated to September 2012. In order to assess the data in detail, we used the search terms “penehyclidine hydrochloride,” “COPD,” “muscarinic receptor,” and “toll-like receptors.” Papers were restricted to those published in the English and Chinese languages, and to “paper” and “review” as the document type. Patents were also reviewed.Results: Our survey mainly yielded the results of research on PHC and the mechanisms of COPD. COPD is a preventable and treatable disease with some significant extrapulmonary manifestations that may contribute to its severity in some patients. Recently, it has been shown that muscarinic receptors may interact with Toll-like receptors. Basic and clinical studies of the relationship between the mechanism of action and the effects of PHC in the respiratory tract have been studied by a number of laboratories and institutions. The main advantages of PHC are that it has few M2

  1. Compatibility of cholecalciferol, haloperidol, imipramine hydrochloride, levodopa/carbidopa, lorazepam, minocycline hydrochloride, tacrolimus monohydrate, terbinafine, tramadol hydrochloride and valsartan in SyrSpend SF PH4 oral suspensions.

    Science.gov (United States)

    Polonini, H C; Silva, S L; Cunha, C N; Brandão, M A F; Ferreira, A O

    2016-04-01

    A challenge with compounding oral liquid formulations is the limited availability of data to support the physical, chemical and microbiological stability of the formulation. This poses a patient safety concern and a risk for medication errors. The objective of this study was to evaluate the compatibility of the following active pharmaceutical ingredients (APIs) in 10 oral suspensions, using SyrSpend SF PH4 (liquid) as the suspending vehicle: cholecalciferol 50,000 IU/mL, haloperidol 0.5 mg/mL, imipramine hydrochloride 5.0 mg/mL, levodopa/carbidopa 5.0/1.25 mg/mL, lorazepam 1.0 mg/mL, minocycline hydrochloride 10.0 mg/mL, tacrolimus monohydrate 1.0 mg/mL, terbinafine 25.0 mg/mL, tramadol hydrochloride 10.0 mg/mL and valsartan 4.0 mg/mL. The suspensions were stored both refrigerated (2 - 8 degrees C) and at controlled room temperature (20 - 25 degrees C). This is the first stability study for these APIs in SyrSpend SF PH4 (liquid). Further, the stability of haloperidol,ilmipramine hydrochloride, minocycline, and valsartan in oral suspension has not been previously reported in the literature. Compatibility was assessed by measuring percent recovery at varying time points throughout a 90 days period. Quantification of the APIs was performed by high performance liquid chromatography (HPLC-UV). Given the percentage of recovery of the APIs within the suspensions, the beyond-use date of the final preparations was found to be at least 90 days for most suspensions both refrigerated and at room temperature. Exceptions were: Minocycline hydrochloride at both storage temperatures (60 days), levodopa/carbidopa at room temperature (30 days), and lorazepam at room temperature (60 days). This suggests that compounded suspensions of APIs from different pharmacological classes in SyrSpend SF PH4 (liquid) are stable.

  2. Effect of Ligustrazine hydrochloride on coagulation reaction and inflammation reaction in single valve replacement patients with rheumatic heart disease undergoing cardiopulmonary bypass

    Institute of Scientific and Technical Information of China (English)

    陈益君

    2014-01-01

    Objective To observe the protection effect of Ligustrazine Hydrochloride(LH)on coagulation reaction and inflammation reaction in single valve replacement patients with rheumatic heart disease undergoing cardiopulmonary bypass(CPB).Methods Totally 40 patients undergoing single valve replacement were recruited in the study and randomly assigned to the two groups,the treatment group

  3. 78 FR 2416 - Notice of Issuance of Final Determination Concerning Rybix® (Tramadol Hydrochloride) Tablets

    Science.gov (United States)

    2013-01-11

    ... (Tramadol Hydrochloride) Tablets AGENCY: U.S. Customs and Border Protection, Department of Homeland Security... (tramadol hydrochloride) tablets. Based upon the facts presented, CBP has concluded in the final determination that India is the country of origin of the Rybix (tramadol hydrochloride) tablets for purposes of...

  4. Randomized Controlled Trial of Levamisole Hydrochloride as Adjunctive Therapy in Severe Falciparum Malaria With High Parasitemia

    Science.gov (United States)

    Maude, Richard J.; Silamut, Kamolrat; Plewes, Katherine; Charunwatthana, Prakaykaew; Ho, May; Abul Faiz, M.; Rahman, Ridwanur; Hossain, Md Amir; Hassan, Mahtab U.; Bin Yunus, Emran; Hoque, Gofranul; Islam, Faridul; Ghose, Aniruddha; Hanson, Josh; Schlatter, Joel; Lacey, Rachel; Eastaugh, Alison; Tarning, Joel; Lee, Sue J.; White, Nicholas J.; Chotivanich, Kesinee; Day, Nicholas P. J.; Dondorp, Arjen M.

    2014-01-01

    Background. Cytoadherence and sequestration of erythrocytes containing mature stages of Plasmodium falciparum are central to the pathogenesis of severe malaria. The oral anthelminthic drug levamisole inhibits cytoadherence in vitro and reduces sequestration of late-stage parasites in uncomplicated falciparum malaria treated with quinine. Methods. Fifty-six adult patients with severe malaria and high parasitemia admitted to a referral hospital in Bangladesh were randomized to receive a single dose of levamisole hydrochloride (150 mg) or no adjuvant to antimalarial treatment with intravenous artesunate. Results. Circulating late-stage parasites measured as the median area under the parasite clearance curves were 2150 (interquartile range [IQR], 0–28 025) parasites/µL × hour in patients treated with levamisole and 5489 (IQR, 192–25 848) parasites/µL × hour in controls (P = .25). The “sequestration ratios” at 6 and 12 hours for all parasite stages and changes in microvascular blood flow did not differ between treatment groups (all P > .40). The median time to normalization of plasma lactate (<2 mmol/L) was 24 (IQR, 12–30) hours with levamisole vs 28 (IQR, 12–36) hours without levamisole (P = .15). Conclusions. There was no benefit of a single-dose of levamisole hydrochloride as adjuvant to intravenous artesunate in the treatment of adults with severe falciparum malaria. Rapid parasite killing by intravenous artesunate might obscure the effects of levamisole. PMID:23943850

  5. Spectrophotometric determination of meclizine hydrochloride and pyridoxine hydrochloride in laboratory prepared mixtures and in their pharmaceutical preparation

    Science.gov (United States)

    Ibrahim, Maha M.; Elzanfaly, Eman S.; El-Zeiny, Mohamed B.; Ramadan, Nesreen K.; Kelani, Khadiga M.

    2017-05-01

    In this paper, three rapid, simple, accurate and precise spectrophotometric methods were developed for the determination of meclizine hydrochloride in the presence of pyridoxine hydrochloride without previous separation. The methods under study are dual wavelength (DWL), ratio difference (RD) and continuous wavelet transform (CWT). On the other hand, pyridoxine hydrochloride (PYH) was determined directly at 291 nm. The methods obey Beer's law in the range of (5-50 μg/mL) for both compounds. All the methods were validated according to the ICH guidelines where the accuracy was found to be 98.29, 99.59, 100.42 and 100.62% for DWL, RD, CWT and PYH; respectively. Moreover the precision of the methods were calculated in terms of %RSD and it was found to be 0.545, 0.372, 1.287 and 0.759 for DWL, RD,CWT and PYH; respectively. The selectivity of the proposed methods was tested using laboratory prepared mixtures and assessed by applying the standard addition technique. So, they can be used for the routine analysis of pyridoxine hydrochloride and meclizine hydrochloride in quality-control laboratories.

  6. Clinical efifcacy of foscarnet sodium combined with valacyclovir hydrochloride in the treatment of rec-urrent genital herpes%膦甲酸钠联合盐酸伐昔洛韦治疗复发性生殖器疱疹的临床效果

    Institute of Scientific and Technical Information of China (English)

    侍小换; 余展国

    2015-01-01

    ObjectiveTo observe the clinical efficacy of foscarnet sodium combined with valacyclovir hydrochloride in the treatment of recurrent genital herpes.MethodSelected from September 2011 to July 2014 in our hospital clinic 90 cases of patients with recurrent genital herpes as the objects of this study. Through group study, observed the difference of curative effect of combination of the two drugs and simple drug use. Compared the three groups before and after treatment with skin lesion area, blister end time and crusting time, the incidence of adverse reactions and recurrence.ResultThree groups of patients after treatment of skin lesion area, blister end time and crusting time were significantly improved compared with before treatment (P0.05). The total effective rate in the observation group was 93.34% (28/30), compared with control group 1 [73.33% (22/30)], control group 2 [76.67% (23/30)] had no signiifcant differences (P>0.05). Three groups of patients with adverse reaction rates had no signiifcant difference (P>0.05). Observation group patients relapse in 2 cases (6.67%), compared with control group 1 [8 patients (26.67%), control group 2 [7 cases (23.33%)] had no signiifcant differences (P<0.05).ConclusionClinical effect of foscarnet sodium combined with valacyclovir hydrochloride in the treatment of recurrent genital herpes is outstanding, safe medication, and low recurrence rate, with obvious efifcacy in reduce stress and improve the quality of life, worthy of clinical application.%目的:观察膦甲酸钠联合盐酸伐昔洛韦治疗复发性生殖器疱疹的临床效果。方法选取2011年9月至2014年7月于本院门诊就诊的90例复发性生殖器疱疹患者为研究对象,通过分组研究,观察联用两种药物与单纯药物使用的疗效差异。比较三组患者治疗前后皮肤损伤面积、止疱时间、结痂时间,不良反应发生情况和复发情况。结果三组患者治疗后皮肤损伤面积、

  7. Stability of ranitidine hydrochloride in total parenteral nutrient solution.

    Science.gov (United States)

    Walker, S E; Bayliff, C D

    1985-03-01

    The stability of ranitidine hydrochloride was studied in a standard total parenteral nutrition (TPN) solution. The Canadian formulation of ranitidine hydrochloride (25 mg/mL) was added in 100-, 200-, and 300-mg doses to approximately 1200 mL of a TPN solution and allowed to stand at room temperature (23 degrees C) for seven days. During this time, samples were drawn at least once a day, and the ranitidine concentration was determined by high-performance liquid chromatography. The ranitidine concentration declined at roughly the same rate regardless of the initial concentration. During the study period, each of the three different concentrations declined to less than 70% of the initial concentration. Approximately 10% of the initial concentration was lost in 48 hours. Ranitidine hydrochloride admixtures were stable for up to 48 hours at room temperature in this standard TPN solution.

  8. Temperature-dependent THz vibrational spectra of clenbuterol hydrochloride

    Science.gov (United States)

    Yang, YuPing; Lei, XiangYun; Yue, Ai; Zhang, Zhenwei

    2013-04-01

    Using the high-resolution Terahertz Time-domain spectroscopy (THz-TDS) and the standard sample pellet technique, the far-infrared vibrational spectra of clenbuterol hydrochloride (CH), a β 2-adrenergic agonist for decreasing fat deposition and enhancing protein accretion, were measured in temperature range of 77-295 K. Between 0.2 and 3.6 THz (6.6-120.0 cm-1), seven highly resolved spectral features, strong line-narrowing and a frequency blue-shift were observed with cooling. However, ractopamine hydrochloride, with some structural and pharmacological similarities to clenbuterol hydrochloride, showed no spectral features, indicating high sensitivity and strong specificity of THz-TDS. These results could be used for the rapid and nondestructive CH residual detection in food safety control.

  9. Spectrophotometric estimation of pioglitazone hydrochloride in tablet dosage form

    Directory of Open Access Journals (Sweden)

    Basniwal Pawan

    2008-01-01

    Full Text Available Two simple, rapid, and precise methods - linear regression equation (LRE and standard absorptivity - were developed and validated for the estimation of pioglitazone hydrochloride in tablet dosage form. The maximum absorbance (lmax of pioglitazone hydrochloride was found to be 269.8 nm in methanol:water:hydrochloric acid (250:250:1. Beer-Lambert law was obeyed in the concentration range of 10-50 µg/ml, and the standard absorptivity was found to be 253.97 dl/g/cm. Both the methods were validated for linearity, accuracy, precision (days, analysts, and instrument variation, and robustness (solvent composition. The numerical values for all parameters lie within the acceptable limits. Pioglitazone hydrochloride was estimated in the range of 99.58-99.97% by LRE method and 100.25-100.75% by standard absorptivity method. At 99% confidence limit, the F-test value for the methods was found to be 1.8767.

  10. Simultaneous spectrophotometric determination of drotaverine hydrochloride and paracetamol in tablet.

    Science.gov (United States)

    Mahaparale, Sonali; Telekone, R S; Raut, R P; Damle, S S; Kasture, P V

    2010-01-01

    Two simple, accurate and reproducible spectrophotometric methods; Q analysis and first order derivative method have been described for the simultaneous estimation of drotaverine hydrochloride and paracetamol in combined tablet dosage form. Absorption maxima of drotaverine hydrochloride and paracetamol in distilled water were found to be 303.5 nm and 243.5 nm respectively. Beer's law was obeyed in the concentration range 5-50 mug/ml for drotaverine and 5-60 mug/ml for paracetamol. In Q analysis method, two wavelengths were selected at isobestic point (277 nm) and lambda(max) of paracetamol (243.5 nm). In first order derivative method, zero crossing point for drotaverine hydrochloride and paracetamol were selected at 303.5 nm and 243.5 nm, respectively. The results of two methods were validated statistically and recovery studies were found to be satisfactory.

  11. Simultaneous spectrophotometric determination of drotaverine hydrochloride and paracetamol in tablet

    Directory of Open Access Journals (Sweden)

    Mahaparale Sonali

    2010-01-01

    Full Text Available Two simple, accurate and reproducible spectrophotometric methods; Q analysis and first order derivative method have been described for the simultaneous estimation of drotaverine hydrochloride and paracetamol in combined tablet dosage form. Absorption maxima of drotaverine hydrochloride and paracetamol in distilled water were found to be 303.5 nm and 243.5 nm respectively. Beer′s law was obeyed in the concentration range 5-50 µg/ml for drotaverine and 5-60 µg/ml for paracetamol. In Q analysis method, two wavelengths were selected at isobestic point (277 nm and λmax of paracetamol (243.5 nm. In first order derivative method, zero crossing point for drotaverine hydrochloride and paracetamol were selected at 303.5 nm and 243.5 nm, respectively. The results of two methods were validated statistically and recovery studies were found to be satisfactory.

  12. Dexmethylphenidate--Novartis/Celgene. Focalin, D-MPH, D-methylphenidate hydrochloride, D-methylphenidate, dexmethylphenidate, dexmethylphenidate hydrochloride.

    Science.gov (United States)

    2002-01-01

    Celgene has developed a chirally pure form of methylphenidate (Ritalin), called dexmethylphenidate [d-methylphenidate, d-methylphenidate hydrochloride, d-MPH; Focalin]. The drug has been launched in the USA and is undergoing registration in Canada for the treatment of children with attention-deficit hyperactivity disorder (ADHD). Dexmethylphenidate is the single isomer version of racemic methylphenidate (Ritalin), which contains the active d isomer of Ritalin. Dexmethylphenidate acts via the inhibition of reuptake of norepinephrine and dopamine. Research is ongoing to further clarify the mode of therapeutic action in ADHD. Dexmethylphenidate was developed with the aim of reducing drug load, adverse events and drug interactions. Dexmethylphenidate provides effective management of attention-deficit hyperactivity disorder at half the dose of Ritalin. In April 2000, worldwide rights (excluding Canada) to dexmethylphenidate were granted to Novartis. Celgene has also granted Novartis rights to all related intellectual properties and patents. Novartis will fund all remaining development and marketing expenses required for regulatory approval and commercialisation of dexmethylphenidate. Crystaal Corporation, the marketing division of Biovail Corporation International, has exclusive Canadian marketing rights for all formulations of dexmethylphenidate. Novartis launched dexmethylphenidate (Focalin) in the USA during Q1 2002. It is available as a D-shaped tablet (2.5, 5 and 10 mg doses). Novartis had planned to use the tradename Ritadex, however the FDA recommended an alternative name due to potential prescribing errors with Ritalin. The finalized tradename to be used is Focalin. In July 2001, a new drug submission was filed with Canada's Therapeutic Products Programme for dexmethylphenidate in the treatment of attention-deficit disorder and attention-deficit hyperactivity disorder. Novartis is also developing an extended-release version of chirally pure dexmethylphenidate

  13. 低钙透析液联合活性维生素D及盐酸司维拉姆治疗血液透析患者继发性甲状旁腺功能亢进的临床观察%Clinical observation of low calcium dialysate combined with activated vitamin D and sevelamer hydrochloride in the treatment of secondary hyperparathyroidism in hemodialysis patients

    Institute of Scientific and Technical Information of China (English)

    段思宇

    2016-01-01

    目的:观察低钙透析液联合活性维生素 D 及盐酸司维拉姆治疗血液透析患者继发性甲状旁腺功能亢进的临床效果。方法40例进行维持性血液透析的慢性肾衰竭患者,采取低钙透析液联合活性维生素 D 及盐酸司维拉姆治疗,观察患者血清全段甲状旁腺激素(iPTH)、血清钙、磷及钙磷乘积变化情况。结果治疗3、6个月后 iPTH 水平(375.11±116.39)、(210.91±108.41)pg/ml,血磷(1.74±0.40)、(1.40±0.34)mmol/L,钙磷乘积(52.26±9.55)、(47.49±9.71)mg2/dl2较治疗前[(651.78±118.41)pg/ml、(2.26±0.38)mmol/L、(64.23±10.14)mg2/dl2]改善(P<0.05),且均未发生明显的不良反应。结论低钙透析液联合活性维生素D 及盐酸司维拉姆治疗血液透析继发性甲状旁腺功能亢进患者具有较好的临床效果,具有临床推广价值。%Objective To investigate clinical effect by low calcium dialysate combined with activated vitamin D and sevelamer hydrochloride in the treatment of secondary hyperparathyroidism in hemodialysis patients. Methods A total of 40 chronic renal failure patients in maintenance hemodialysis received low calcium dialysate combined with activated vitamin D and sevelamer hydrochloride for treatment. Changes of serum intact parathyroid hormone (iPTH), serum calcium, phosphorus, and calcium-phosphorus product were observed in patients. Results After 3 and 6 months of treatment, the patients had better iPTH level as (375.11±116.39), (210.91±108.41) pg/ml, serum phosphorus as (1.74±0.40), (1.40±0.34) mmol/L, and calcium-phosphorus product as (52.26±9.55), (47.49±9.71) mg2/dl2 than those before treatment[(651.78±118.41) pg/ml, (2.26±0.38) mmol/L, (64.23±10.14) mg2/dl2](P<0.05). There were no obvious adverse reactions. Conclusion Implement of low calcium dialysate combined with activated vitamin D and sevelamer hydrochloride provides remarkably clinical effect in treating secondary hyperparathyroidism in hemodialysis patients

  14. Spectrophotometric determination of ritodrine and isoxsuprine hydrochlorides using 4-aminoantipyrine.

    Science.gov (United States)

    Revanasiddappa, H D; Manju, B G

    2000-01-01

    A simple, accurate, and rapid method for the quantitative determination of ritodrine hydrochloride (RTH) and isoxsuprine hydrochloride (ISH) in both pure and dosage forms, is described. The method is based on the development of pink colored product as a result of the condensation of 4-aminoantipyrine with phenols in the presence of an alkaline oxidizing agent. The resulting products are measured at 510 nm for both drugs, with molar absorptivities of 0.98 x 10(4) and 1.20 x 10(4) L/mol x cm for RTH and ISH, respectively. A study of the effect of commonly associated excipients revealed that they did not cause interference.

  15. Enantiomeric Separation of Meptazinol Hydrochloride by Capillary Electrophoresis

    Institute of Scientific and Technical Information of China (English)

    YUYun-qiu; CHENYan; LINi; QIUZhui-bai

    2004-01-01

    Aim To establish a capillary electrophoresis method for enantiomerie separation of meptazinol hydrochloride. Methods The separation conditions such as cyclodextrin(CD)type, buffer pH, concentration of 2,3,6-O-triInethyl-β-cyclodextrin and organic additives were optimized. An optimum concentration was 30 mmol·L-1 phosphate (pH 7.02)with 10% (W/V) TM-β-CD and 2% acetonitrile. Results Basehne resolution of the enantiomer was readily achieved using 2,3,6-O-trimethyl-β-cyclodextrin. Conclusion This is a convenient method for fast enantiomeric resolution of meptazinol hydrochloride.

  16. [Effect of topical exhedrine hydrochloride on muco-ciliary transport].

    Science.gov (United States)

    Grammatica, L; Fiorella, R

    1983-07-30

    The time of nasal M.C.T. (Mucus Ciliar Transport) was studied by the indirect objective method of bleu-sky in 30 healthy subjects before and after the application of efedrina hydrochloride in water solution associated with timolo, eucaliptolo, mentolo essence of canfora monobramata and clorbutamolo. The time of nasal M.C.T., regular in the 87% of the subjects during the first determination was found extended in almost all of the cases after the application of vasoconstrictor (85%). This experimental data may be caused both by a direct effect of efedrina hydrochloride and by the substances associated in the solution and their physical characteristics.

  17. Clinical efficacy of efonidipine hydrochloride, a T-type calcium channel inhibitor, on sympathetic activities. Examination using spectral analysis of heart rate/blood pressure variabilities and {sup 123}I-Metaiodobenzylguanidine myocardial scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Harada, Kenji; Nomura, Masahiro; Nishikado, Akiyoshi; Uehara, Kouzoh; Nakaya, Yutaka; Ito, Susumu [Tokushima Univ. (Japan). School of Medicine

    2003-02-01

    Dihydropyridine Ca antagonists cause reflex tachycardia related to their hypotensive effects. Efonidipine hydrochloride has inhibitory effects on T-type Ca channels, even as it inhibits reflex tachycardia. In the present study, the influence of efonidipine hydrochloride on heart rate and autonomic nervous function was investigated. Using an electrocardiogram and a tonometric blood pressure measurement, autonomic nervous activity was evaluated using spectral analysis of heart rate/systolic blood pressure variability. Three protocols were used: a single dose of efonidipine hydrochloride was administered orally to healthy subjects with resting heart rate values of 75 beats/min or more (high-heart rate (HR) group) and to healthy subjects with resting heart rate values less than 75 beats/min (low-HR group); efonidipine hydrochloride was newly administered to untreated patients with essential hypertension, and autonomic nervous activity was investigated after a 4-week treatment period; and patients with high heart rate values ({>=}75 beats/min) who had been treated with a dihydropyridine L-type Ca channel inhibitor for 1 month or more were switched to efonidipine hydrochloride and any changes in autonomic nervous activity were investigated. In all protocols, administration of efonidipine hydrochloride decreased the heart rate in patients with a high heart rate, reduced sympathetic nervous activity, and enhanced parasympathetic nervous activity. In addition, myocardial scintigraphy with {sup 123}I-metaiodobenzylguanidine showed significant improvement in the washout rate and heart to mediastinum (H/M) ratio of patients who were switched from other dihydropyridine Ca antagonists to efonidipine hydrochloride. Efonidipine hydrochloride inhibits increases in heart rate and has effects on the autonomic nervous system. It may be useful for treating hypertension and angina pectoris, and may also have a cardiac protective function. (author)

  18. A multicentric, open label, randomised, postmarketing efficacy study comparing multidose of lincomycin hydrochloride capsule 500 mg with multidose cefpodoxime proxetil tablet 200 mg in patients with tonsillitis, sinusitis.

    Science.gov (United States)

    Kothadiya, Ajay

    2012-08-01

    Tonsillitis causes considerable short and medium term morbidity, and can be recurrent. Sinusitis can be acute (less than 4 weeks), subacute (4-8 weeks) or chronic (8 weeks or more). To study the comparative efficacy and safety of multidose treatments of lincomycin hydrochloride 500 mg capsules against cefpodoxime proxetil 200 mg tablets on its outcome in the Indian scenario are the aims and objective of the study. A total of 41 tonsillitis, sinusitis cases of either gender aged above 18 years were enrolled in the study. The diagnosis of sonsillitis, sinusitis was made based on examination of symptoms and throat swab. A randomised treatment of either lincomycin hydrochloride 500 mg capsules or cefpodoxime proxetil 200 mg tablets twice daily for five days alongwith other concomitant medications depending on related symptoms was given to 40 patients. At the end of study, all patients were re-evaluated and the response rate was assessed. The most common clinical symptoms were body temperature, headache, throat pain, postnasal discharge, mucopus, odynophagia, sinus tenderness, nasal congestion, pharyngeal congestion and tonsillar congestion. The overall response rate of lincomycin hydrochloride in all the symptoms except headache was more effective than cefpodoxime proxetil. Out of 100% (n = 20) patients in each group, 67.89% in lincomycin and 52.27% in cefpodoxime patients achieved complete relief, in all the clinical symptoms. The study suggests that lincomycin hydrochloride capsules, a conventional antibiotic indicates effective treatment for relief from tonsillitis and sinusitis, as compared to new third generation antibiotic.

  19. Effect of penehyclidine hydrochloride on patients with acute lung injury and its mechanisms

    Institute of Scientific and Technical Information of China (English)

    LI Bai-qiang; SUN Hai-chen; NIE Shi-nan; SHAO Dan-bing; LIU Hong-mei; QIAN Xiao-ming

    2010-01-01

    Objective: To assess the effects of penehyclidine hydrochloride on patients with acute lung injury (ALI), to observe the expression of Toll-like receptor 4 (TLR4) on the peripheral monocytes of ALI patients and changes of inflammatory & anti-inflammatory cytokines and to investigate the mechanism of TLR4 in ALI.Methods: Forty-five patients with ALI were randomly divided into penehyclidine hydrochloride treatment group (P group, n=21) and conventional treatment group (control group, C group, n=24). Patients in both groups received conventional treatment, including active treatment of the primary disease, respiratory support, nutritional support and fluid management therapy, while those in P group were given penehyclidine hydrochloride (1 mg, im, q. 12 h) in addition.The TLR4 expression of 20 healthy volunteers were detected.The clinical effect, average length of stay in ICU and hospital,values of PaO2 and PaO2/FiO2, expression of TLR4 on the surface of peripheral blood mononuclear cells and some serum cytokines were evaluated for 48 h.Results: The general conditions of the two groups were improved gradually and PaO2 increased progressively.Compared with 0 h, PaO2 and PaO2/FiO2 at 6, 12, 24 and 48 h after treatment were significantly increased (P<0.05). The improvement in P group was obviously greater than that in C group (P<0.05). The average length of hospitalization showed no difference between the two groups, but penehyclidine hydrochloride significantly decreased the average length of stay in ICU (t=3.485, P<0.01). The expression of TLR4 in two groups were both obviously higher than that of healthy volunteers (P<0.01). It decreased significantly at 24 h (t=2.032, P<0.05) and 48 h (t=3.620, P<0.01)and was lower in P group than in C group. The patients who showed a higher level of TLR4 expression in early stage had a worse prognosis and most of them developed acute respiratory distress syndrome (ARDS). The incidence of ARDS was 23.8% in P group and 29

  20. Comparative antifungal efficacy of light-activated disinfection and octenidine hydrochloride with contemporary endodontic irrigants.

    Science.gov (United States)

    Eldeniz, Ayce Unverdi; Guneser, Mehmet Burak; Akbulut, Makbule Bilge

    2015-02-01

    The aim of this study was to evaluate the antifungal effects of light-activated disinfection (LAD) in comparison with contemporary root canal irrigation solutions: sodium hypochlorite and 2% chlorhexidine gluconate and a new wound antiseptic, octenidine hydrochloride. Seventy extracted teeth having single root canals were contaminated with Candida albicans for 14 days. The samples were divided into five experimental (n = 10) and two control (positive and negative) groups (n = 10): (1) LAD with toluidine blue O, (2) octenidine hydrochloride (OCT), (3) 2.5% sodium hypochlorite (2.5% NaOCl), (4) 5.25% sodium hypochlorite (5.25% NaOCl) and (5) 2% chlorhexidine. Five millilitres of each test solution was applied for 3 min, and irradiation time used for LAD was 30 s. After treatment, the dentin chips were collected from inner canal walls into vials containing phosphate buffered saline, vortexed, serially diluted, seeded on Tryptic Soy Agar plates and incubated (37 °C, 48 h). The number of colony-forming units was then counted. Differences between LAD group and positive control group were statistically significant (P irrigated with OCT, 2.5% NaOCl, 5.25% NaOCl and 2% chlorhexidine groups (CFU = 0). Within the limitations of this ex vivo study, LAD had minimal antimicrobial effect on C. albicans when used 30 s, and further modifications in LAD protocol are required to improve its antifungal capability. A new wound antiseptic, octenidine hydrochloride, demonstrated better potential than LAD in elimination of Candida albicans cells and may be a promising alternative to NaOCl and chlorhexidine solutions in future.

  1. Effects of feeding zilpaterol hydrochloride with and without monensin and tylosin on carcass cutability and meat palatability of beef steers.

    Science.gov (United States)

    Hilton, G G; Montgomery, J L; Krehbiel, C R; Yates, D A; Hutcheson, J P; Nichols, W T; Streeter, M N; Blanton, J R; Miller, M F

    2009-04-01

    An experiment was conducted using 200 beef carcasses to evaluate the effects of feeding zilpaterol hydrochloride with or without monensin and tylosin on carcass cutability and meat sensory variables. The experiment was conducted using a randomized complete block design with treatments arranged as a 2 (no zilpaterol vs. zilpaterol) x 2 (monensin and tylosin withdrawn vs. monensin and tylosin fed) factorial. Cattle (n=3,757) were fed zilpaterol hydrochloride, a beta(2)-adrenergic agonist, for 30 d at the end of the finishing period and withdrawn from zilpaterol hydrochloride for the last 5 d on feed. Five carcasses (weighing between 305 and 421 kg and free of slaughter defects) were selected from each of 40 feedlot treatment pens. Strip loins from the left sides were collected for sensory analysis and Warner-Bratzler shear force (WBSF) testing, and the rib was collected for 9th, 10th, 11th-rib dissections. A subsample of 3 carcass right sides per pen was fabricated into boneless subprimals according to Institutional Meat Purchase Specifications. Carcasses from zilpaterol-fed steers had greater (P or= 0.26). For the main effect of monensin and tylosin, withdrawal of monensin and tylosin decreased (P=0.01) consumer juiciness scores, although other yield and compositional measurements were not affected (P >or= 0.07). Zilpaterol is a strong repartitioning agent that increases meat yield through increased protein and decreased fat deposition.

  2. Clinical Observation of Icotinib Hydrochloride for Advanced Non-small Cell Lung Cancer Patients with EGFR Status Identified

    Directory of Open Access Journals (Sweden)

    Xi LI

    2015-12-01

    Full Text Available Background and objective Icotinib is the first self-developed small molecular drug in China for targeted therapy of lung cancer. Compared to the other two commercially available epidermal growth factor receptor (EGFR tyrosine kinase inhibitors, gefitinib and erlotinib, icotinib is similar to them in chemical structure, mechanism of activity and therapeutic effects. To explore the efficacy and side effects of icotinib hydrochloride in the treatment of the advanced non-small cell lung cancer (NSCLC patients with EGFR mutation and wild-type. Methods Patients with advanced NSCLC who were treated with icotinib hydrochloride in Beijing Chest Hospital were retrospective analyzed from March 2009 to December 2014. Results The clinical data of 124 patients (99 with EGFR mutation and 25 with wild type with advanced NSCLC were enrolled in this study. The patients’ overall objective response rate (ORR was 51.6 % and the disease control rate (DCR was 79.8%; The patients with EGFR mutation, ORR was 63.6%, DCR was 93.9%. The ORR was 4.0% and the DCR was 24.0% in the wild-type patients. Median progression-free survival (PFS with icotinib treatment in EGFR mutation patients was 10.5 months and 1.0 month in wild-type patients. The major adverse events were mild skin rash (30.6% and diarrhea (16.1%. Conclusion Monotherapy with icotinib hydrochloride is effective and tolerable for the advanced NSCLC EGFR mutation patients.

  3. Simultaneous chemometric determination of pyridoxine hydrochloride and isoniazid in tablets by multivariate regression methods.

    Science.gov (United States)

    Dinç, Erdal; Ustündağ, Ozgür; Baleanu, Dumitru

    2010-08-01

    The sole use of pyridoxine hydrochloride during treatment of tuberculosis gives rise to pyridoxine deficiency. Therefore, a combination of pyridoxine hydrochloride and isoniazid is used in pharmaceutical dosage form in tuberculosis treatment to reduce this side effect. In this study, two chemometric methods, partial least squares (PLS) and principal component regression (PCR), were applied to the simultaneous determination of pyridoxine (PYR) and isoniazid (ISO) in their tablets. A concentration training set comprising binary mixtures of PYR and ISO consisting of 20 different combinations were randomly prepared in 0.1 M HCl. Both multivariate calibration models were constructed using the relationships between the concentration data set (concentration data matrix) and absorbance data matrix in the spectral region 200-330 nm. The accuracy and the precision of the proposed chemometric methods were validated by analyzing synthetic mixtures containing the investigated drugs. The recovery results obtained by applying PCR and PLS calibrations to the artificial mixtures were found between 100.0 and 100.7%. Satisfactory results obtained by applying the PLS and PCR methods to both artificial and commercial samples were obtained. The results obtained in this manuscript strongly encourage us to use them for the quality control and the routine analysis of the marketing tablets containing PYR and ISO drugs.

  4. Ractopamine hydrochloride on performance and carcass traits of confined Nellores cattle

    Directory of Open Access Journals (Sweden)

    João Luis Kill

    2015-10-01

    Full Text Available The effect of four levels of inclusion (0; 450; 900 and 1,350g T-1 of Ractopamine hydrochloride was assessed concerning weight gain, feed conversion, dry matter intake, carcass traits and quality of castrated male cattle meat in confinement. Forty Nellore steers were used, with an average age of 26 months and initial average weight of 423.4±2.7kg, in a randomized block experimental design with four treatments and ten replications. The diet was fixed with the ratio of forage to concentrate dry matter of 75.3:24.7. A Linear positive effect observed was the inclusion of Ractopamine on daily weight gain and linear negative effect on feed conversion, highlighting the improvements with the increasing inclusion of Ractopamine hydrochloride. In relation to carcass traits, the linear effect was negative for fat thickness and no differences were found regarding the hot carcass weight ; carcass yield; area, width and depth of rib eye area of the Longissimus dorsi muscle, and noble courts. In relation to dry matter intake, the comparison of the treatments demonstrated that Ractopamine didn't influence negatively, which highlights its positive effect on the animal performance. The use of Ractopamine improves performance and decreases de amount of superficial fat in male nellore carcass in confinement.

  5. Effects of roxatidine acetate hydrochloride and cimetidine on the pharmacokinetics of theophylline in healthy subjects.

    Science.gov (United States)

    Yoshimura, N; Takeuchi, H; Ogata, H; Ishioka, T; Aoi, R

    1989-06-01

    The effects of roxatidine acetate hydrochloride and cimetidine during multiple dosing on the pharmacokinetics of theophylline was studied in nine healthy volunteers, five smokers and four non-smokers, in comparison with placebo treatment. Cimetidine reduced the terminal elimination rate constant and the total body clearance of theophylline from 0.119 to 0.101 h-1 (p less than 0.05) and from 31.2 to 26.5 ml/min (p less than 0.05), respectively, in comparison with those of placebo. There was no significant change in the volume of distribution (16.3 l for placebo and 15.5 l for cimetidine) and the renal clearance (4.5 ml/min for placebo and 3.9 ml/min for cimetidine). Roxatidine acetate hydrochloride did not significantly influence theophylline disposition in comparison with placebo treatment. The interaction of cimetidine on theophylline disposition was observed in both smokers and non-smokers, but the degree was greater in smokers.

  6. Characterization of nicardipine hydrochloride-induced cell injury in human vascular endothelial cells.

    Science.gov (United States)

    Ochi, Masanori; Kawai, Yoshiko; Tanaka, Yoshiyuki; Toyoda, Hiromu

    2015-02-01

    Nicardipine hydrochloride (NIC), a dihydropyridine calcium-channel blocking agent, has been widely used for the treatment of hypertension. Especially, nicardipine hydrochloride injection is used as first-line therapy for emergency treatment of abnormally high blood pressure. Although NIC has an attractive pharmacological profile, one of the dose-limiting factors of NIC is severe peripheral vascular injury after intravenous injection. The goal of this study was to better understand and thereby reduce NIC-mediated vascular injury. Here, we investigated the mechanism of NIC-induced vascular injury using human dermal microvascular endothelial cells (HMVECs). NIC decreased cell viability and increased percent of dead cells in a dose-dependent manner (10-30 μg/mL). Although cell membrane injury was not significant over 9 hr exposure, significant changes of cell morphology and increases in vacuoles in HMVECs were observed within 30 min of NIC exposure (30 μg/mL). Autophagosome labeling with monodansylcadaverine revealed increased autophagosomes in the NIC-treated cells, whereas caspase 3/7 activity was not increased in the NIC-treated cells (30 μg/mL). Additionally, NIC-induced reduction of cell viability was inhibited by 3-methyladenine, an inhibitor of autophagosome formation. These findings suggest that NIC causes severe peripheral venous irritation via induction of autophagic cell death and that inhibition of autophagy could contribute to the reduction of NIC-induced vascular injury.

  7. Anesthesia with topical lidocaine hydrochloride gauzes in acute traumatic wounds in triage, a pilot study.

    Science.gov (United States)

    Ridderikhof, Milan L; Leenders, Noukje; Goddijn, Helma; Schep, Niels W; Lirk, Philipp; Goslings, J Carel; Hollmann, Markus W

    2016-09-01

    Topical application of lidocaine in wounds has been studied in combination with vasoconstrictive additives, but the effect without these additives is unknown. The objective was to examine use of lidocaine-soaked gauzes without vasoconstrictive agents, in traumatic wounds in adult patients, applied in triage. A prospective pilot study was performed during 6 weeks in the Emergency Department of a level 1 trauma center. Wounds of consecutive adult patients were treated with a nursing protocol, consisting of lidocaine hydrochloride administration directly into the wound and leaving a lidocaine-soaked gauze, until wound treatment. Primary outcome was need for infiltration anesthesia. Secondary outcomes were Numerical Rating Scale (NRS) pain scores, adverse events and patient and physician satisfaction. Forty patients with a traumatic wound were included, 85% male with a wound on the arm. Thirty-seven patients needed a painful procedure as wound treatment. When suturing was necessary, 77% required additional infiltration anesthesia. Mean NRS pain scores decreased from 3.3 to 2.2 after application of the lidocaine gauze. No adverse events were recorded. Of the patients, 60% were satisfied with use of the lidocaine gauzes, compared to 40% of physicians. Lidocaine hydrochloride (2%) gauzes without vasoconstrictive additives cannot replace infiltration anesthesia in traumatic wounds. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Diffusion Coefficients ofl-Lysine Hydrochloride and l-Arginine Hydrochloride in Their Aqueous Solutions at 25℃

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The diffusion coefficients** ofl-lysine hydrochloride andl-arginine hydrochloride in their aqueous solu- tions at 25℃ were determined by the metallic diaphragm cell method which is characterized by accuracy, promptness and convenience. Meanwhile, the densities and viscosities of the solutions were also determined. Based on all these data a semi-empirical model for correlating the diffusion coefficients of solid organic salts in their aqueous solutions at 25℃ was proposed. The fitting result of this model is comparatively satisfactory. Compared to a former model, Gordon Model, this model can avoid a number of difficulties and arduous work.

  9. 度洛西汀联合硫辛酸治疗糖尿病周围神经病变性疼痛的疗效观察%Therapeutic effect analysis of duloxetine hydrochloride combined with alpha-lipoic acid in treatment of diabetic peripheral neuropathic pain

    Institute of Scientific and Technical Information of China (English)

    沈柿芬; 郭道骝

    2016-01-01

    目的:探讨度洛西汀联合硫辛酸治疗糖尿病周围神经病变性疼痛的有效性及安全性。方法:将78例糖尿病周围神经病变性疼痛患者随机分为两组,西汀组口服度洛西汀,联合组口服度洛西汀和静脉滴注硫辛酸,比较两组疗效。结果:两组治疗后正中神经感觉传导速度(median nerve conduction velocity,MNCV)、腓总神经感觉传导速度(phil nerve conduction velocity,PNCV)、尺神经感觉传导速度(ulnar nerve conduction velocity,UNCV)均显著提高(P0.05);两组治疗前、治疗8周后胆固醇(TC)、甘油三酯(TG)、丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、血肌酐(SCr)指标水平均无显著性变化(P>0.05)。结论:度洛西汀联合硫辛酸治疗糖尿病周围神经病变性疼痛,能有效改善患者神经功能,减轻疼痛症状,且安全可靠。%Objective:By comparing duloxetine combination with alpha-lipoic acid and duloxetine in the therapeutic effect of painful diabetic neuropathy, to explore the efficacy and safety of duloxetine combination with alpha-lipoic acid treatment on diabetic peripheral neuropathic pain (DPNP) is optimal.Methods:78 cases with painful diabetic neuropathy of type 2 diabetes were recruited from our department and randomly divided into two groups, which were duloxetine in combination with alpha-lipoic acid group and duloxetine treatment group.Results: Compared to baseline, median nerve sensory conduction velocity (MNCV), Phil nerve conduction velocity (PNCV) and ulnar nerve conduction velocity (UNCV) of both groups were better (P0.05). Before treatment, no statistically signiifcant differences were detected in total cholesterol (TC), triglycerides (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum creatinine (SCr) between two groups (P>0.05).Conclusion:Duloxetine hydrochloride combined with alpha-lipoic acid has a good

  10. Pyridoxine hydrochloride treatment of carpal tunnel syndrome: a review.

    Science.gov (United States)

    Aufiero, Elaine; Stitik, Todd P; Foye, Patrick M; Chen, Boqing

    2004-03-01

    It has been hypothesized that idiopathic carpal tunnel syndrome (CTS) is a manifestation of vitamin B6 deficiency. Some claim that B6 supplementation can alleviate symptoms. Others argue that pain relief occurs because of vitamin B6's anti-nociceptive properties or because B6 supplementation addresses an unrecognized peripheral neuropathy. Few studies on CTS and B6 employed electrodiagnostic techniques in diagnosis, and few showed a correlation between symptoms and improved electrodiagnostic parameters with supplementation. Other studies failed to measure or estimate B6 levels. Nevertheless, it appears reasonable to recommend vitamin B6 supplementation to people with CTS. Some patients will improve symptomatically with low risks of toxicity in recommended doses.

  11. Release Characteristics of Diltiazem Hydrochloride Wax-Matrix ...

    African Journals Online (AJOL)

    Michael Horsfall

    diltiazem hydrochloride-wax matrix granules with sintering. ... The drug release was by Higuchi controlled diffusion mechanism and it followed ... of plastic matrix tablets. Polymer films with different permeability have been .... More so, with increase in temperature and ..... characterization of ibuprofen-cetyl alcohol beads by.

  12. Study on the syhthesis process of tetracaine hydrochloride

    Science.gov (United States)

    Li, Wenli; Zhao, Jie; Cui, Yujie

    2017-05-01

    Tetrachloride hydrochloride is a local anesthetic with long-acting ester, and it is usually present in the form of a hydrochloride salt. Firsleb first synthesized the tetracaine by experiment in 1928, which is one of the recognized clinical potent anesthetics. This medicine has the advantages of stable physical and chemical properties, the rapid role and long maintenance. Tetracaine is also used for ophthalmic surface anesthesia as one of the main local anesthetic just like conduction block anesthesia, mucosal surface anesthesia and epidural anesthesia. So far, the research mainly engaged in its clinical application research, and the research strength is relatively small in the field of synthetic technology. The general cost of the existing production process is high, and the yield is low. In addition, the reaction time is long and the reaction conditions are harsh. In this paper, a new synthetic method was proposed for the synthesis of tetracaine hydrochloride. The reaction route has the advantages of few steps, high yield, short reaction time and mild reaction conditions. The cheap p-nitrobenzoic acid was selected as raw material. By esterification with ethanol and reaction with n-butyraldehyde (the reaction process includes nitro reduction, aldol condensation and hydrogenation reduction), the intermediate was transesterified with dimethylaminoethanol under basic conditions. Finally, the PH value was adjusted in the ethanol solvent. After experiencing 4 steps reaction, the crude tetracaine hydrochloride was obtained.

  13. Surface tension of compositions of polyhexametyleneguanidine hydrochloride - surfactants

    Directory of Open Access Journals (Sweden)

    S. Kumargaliyeva

    2012-12-01

    Full Text Available We made up songs bactericidal polyhexamethyleneguanidine hydrochloride (metacyde with the surface-active substances - anionic sodium dodecylsulfate, cationic cetylpyridinium bromide, and nonionic Tween-80 and measured the surface tension of water solutions. The study showed that the composition metacyde with surface-active agents have a greater surface activity than the individual components.

  14. 21 CFR 524.1982 - Proparacaine hydrochloride ophthalmic solution.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Proparacaine hydrochloride ophthalmic solution. 524.1982 Section 524.1982 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... longterm toxicity of proparacaine is unknown. Prolonged use may possibly delay wound healing. (d...

  15. Acute generalized exanthematous pustulosis caused by terazosin hydrochloride.

    Science.gov (United States)

    Speck, Laura M; Wilkerson, Michael G; Perri, Anthony J; Kelly, Brent C

    2008-04-01

    Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous eruption mainly provoked by drugs. A case of AGEP in a 74-year-old male that was attributed to the ingestion of terazosin hydrochloride is presented. This is the first reported case of this association in medical literature. The history, clinical presentation, and pathogenesis of AGEP are discussed.

  16. Cradle-to-gate life cycle inventory of vancomycin hydrochloride.

    Science.gov (United States)

    Ponder, Celia; Overcash, Michael

    2010-02-15

    A life cycle analysis on the cradle-to-gate production of vancomycin hydrochloride, which begins at natural resource extraction and spans through factory (gate) production, not only shows all inputs, outputs, and energy usage to manufacture the product and all related supply chain chemicals, but can highlight where process changes would have the greatest impact on raw material and energy consumption and emissions. Vancomycin hydrochloride is produced by a low-yield fermentation process that accounts for 47% of the total cradle-to-gate energy. The fermentation step consumes the most raw materials and energy cradle-to-gate. Over 75% of the total cradle-to-gate energy consumption is due to steam use; sterilization within fermentation is the largest user of steam. Aeration and agitation in the fermentation vessels use 65% of the cradle-to-gate electrical energy. To reduce raw materials, energy consumption, and the associated environmental footprint of producing vancomycin hydrochloride, other sterilization methods, fermentation media, nutrient sources, or synthetic manufacture should be investigated. The reported vancomycin hydrochloride life cycle inventory is a part of a larger life cycle study of the environmental consequences of the introduction of biocide-coated medical textiles for the prevention of MRSA (methicillin-resistant Staphylococcus aureus) nosocomial infections.

  17. Asymmetric Synthesis of (+)-(11 R,12S)-Mefloquine Hydrochloride

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The asymmetric synthesis of (+)-(11R,12S)-mefloquine hydrochloride, an antimalarial drug, was accomplished from commercially available 2-trifluoromethylaniline, ethyl 4,4,4-trifluoroacetoacetate and cyclopentanone in 7 steps with a 14% overall yield. The key steps were proline-catalyzed asymmetric direct aldol reaction and Beck-mann rearrangement. The absolute configuration was assigned by a Mosher's method.

  18. Amitriptyline-related peripheral neuropathy relieved during pyridoxine hydrochloride administration.

    Science.gov (United States)

    Meadows, G G; Huff, M R; Fredericks, S

    1982-11-01

    Tricyclic antidepressants rarely cause peripheral neuropathy. In fact, this class of drugs has been used to control the symptoms of pain and paresthesia that accompany peripheral neuropathy. We report peripheral paresthesias that occurred in a 39-year-old female during five years of amitriptyline administration. The patient's symptoms were relieved by oral pyridoxine hydrochloride, associated with elevated plasma pyridoxal phosphate.

  19. 羟考酮注射液滴定法在急诊创伤后疼痛处理的临床观察%Clinical application of oxycodone hydrochloride injection with titration to analgesia after emergency treatment of post-trau-matic preoperative pain management

    Institute of Scientific and Technical Information of China (English)

    缪小勇; 徐葭; 曹建平

    2015-01-01

    Objective To investigate the efficacy and safety of oxycodone hydrochloride injection with titration to analgesic after emer-gency treatment of post-traumatic preoperative pain management. Methods Totally 120 cases of post-traumatic acute severe pain (VAS>80),titration of oxycodone injection to deal with the pain of patients. SBP,DBP,HR,RR,SpO2 of the patient with medication after 5,10,15,20 minutes were observed and recorded. The VAS values,ramesay sedation scores after 5,10,15,20 minutes were eval-uated and recorded. The rate of adverse reaction happened cases of patients with nausea,vomiting,respiratory depression,urinary reten-tion were Recorded. Total consumption of patients with oxycodone was calculated. Results SBP,DBP,HR had declined obviously of all time points after the treatment of,the difference was statistically significant (P0. 05). Delivery after the observation indexes were within the normal range. VAS pain score of stat-ic,dynamic to different time points after the treatment were significantly lower,the difference was statistically significant (P80)患者120例,采用羟考酮注射液滴定法对患者的疼痛进行处理,观察并记录患者给药后5、10、15、20 min各时间点的收缩压( SBP)、舒张压( DBP)、心率( HR)、呼吸频率( RR)、脉搏氧饱和度( SpO2 );评判并记录给药后5、10、15、20 min各时间点的静态、动态VAS值,Ramesay镇静评分;记录患者恶心、呕吐、呼吸抑制、尿潴留等不良反应发生率;计算患者羟考酮的总用量. 结果 与给药前比较,给药后各时间点的SBP、DBP、HR有明显下降,差异有统计学意义(P0. 05);给药后各项呼吸循环观察指标均在正常范围之内. 给药后各时间点的静态、动态VAS疼痛评分均有明显下降,差异有统计学意义( P<0. 05 );给药后10、15 min两个时间点患者的静态疼痛达到缓解标准;镇静评分有明显差异,差异有统计学意义( P <0. 05 );发生恶心6 (5. 0%)

  20. Comparação entre o uso tópico do fumarato de cetotifeno 0,025% e do cloridrato de olopatadina 0,1% no tratamento da ceratoconjuntivite primaveril Comparative study between 0.025% ketotifen fumarate and 0.1% olopatadine hydrochloride in the treatment of vernal keratoconjunctivitis

    Directory of Open Access Journals (Sweden)

    Wilson Takashi Hida

    2006-12-01

    Full Text Available OBJETIVO: O objetivo desse estudo foi comparar as soluções oftálmicas de fumarato de cetotifeno 0,025% e de cloridrato de olopatadina 0,1% em pacientes portadores de ceratoconjuntivite primaveril. MÉTODOS: Avaliação realizada em um único centro, simples-cega, comparando-se paralelamente cetotifeno e olopatadina. As medicações foram avaliadas em 4 momentos (dias 1, 7, 14 e 21 por meio de tabelas de graduações padronizadas. A freqüência de eventos adversos foi a principal variável de segurança. RESULTADOS: Na avaliação da evolução do prurido ocular, ardor, lacrimejamento, hiperemia conjuntival, secreção e fotofobia observou-se que o uso tópico do cetotifeno proporcionou melhora significante deste sintoma em relação a olopatadina (p>0,05. Observou-se que a partir do 7º dia de tratamento os pacientes em uso da olopatadina tinham menos ardor, em relação aos que fizeram uso do cetotifeno, mas após o 21º dia essa relação inverteu. Na comparação da sensação de corpo estranho, papilas e pontos de Horner-Trantas evidenciou-se equivalência sem significância estatística. CONCLUSÃO: Concluímos que ambas são drogas equivalentes e atuaram de forma eficaz e segura na remissão dos sintomas relacionados à conjuntivite alérgica primaveril. Houve diferença a favor do cetotifeno (pPURPOSE: To compare the topical use of 0.025% ketotifen fumarate and 0.1% olopatadine hydrochloride in the treatment of patients with vernal keratoconjunctivitis. METHODS: A study performed in one center, simple masked, parallel-group compared ketotifen and olopatadine. These patients were evaluated on four visits during the treatment (days 1, 7, 14 and 21, defined by ratings scores. Adverse events were the main variable of safety rating. RESULTS: On evaluating ocular itching, burning, tearing, conjunctival hyperemia, mucous discharge and photophobia, the ketotifen group showed a significant improvement of total signs and symptoms (p<0

  1. Primerjalna raziskava terapevtske enakovrednosti med testnim in referenčnim zdravilom fiksne kombinacije 3 miligramov benzidaminijevega klorida in 1 miligrama cetilpiridinijevega klorida pri preiskovancih z vnetim žrelom, povezanim z okužbami zgornjih dihal: A comparison of therapeutic equivalence between test and reference formulations of the fixed combination of 3 milligrams benzydamine hydrochloride and 1 milligram cetylpyridinium chloride in the treatment of sore throat associated with upper respiratory tract infections:

    OpenAIRE

    Košir, Primož

    2015-01-01

    Cetylpyridinium chloride acts as a broad-spectrum antiseptic. Its antibacterial effect has been recognized for many years. Benzydamine hydrochloride is an indazole, a non-steroidal anti-inflammatory drug that has analgesic, anti-inflammatory, local anesthetic and antipyretic properties and has been widely used across Europe for nearly four decades. The comŽ bination of antiseptic properties of cetylpyridinium chloride and anti-inflammatory and analgesic action of benzydamine hydrochloride is ...

  2. Assessment of betahistine dihydrochloride effectiveness in the treatment of disturbance of balance system, based on analysis of doctors and patients questionnaires results

    National Research Council Canada - National Science Library

    Jurkiewicz, Dariusz; Kantor, Ireneusz; Usowski, Jacek

    2006-01-01

    .... The aim of our work was to analyze effectiveness of betahistine hydrochloride (Betaserc) treatment on vertigo, nausea, vomiting, tinnitus and progressive hearing loss basing on the medical assessment...

  3. Suppression of Invasion and Metastasis of Triple-Negative Breast Cancer Lines by Pharmacological or Genetic Inhibition of Slug Activity

    Directory of Open Access Journals (Sweden)

    Giovanna Ferrari-Amorotti

    2014-12-01

    Full Text Available Most triple-negative breast cancers (TNBCs exhibit gene expression patterns associated with epithelial-to-mesenchymal transition (EMT, a feature that correlates with a propensity for metastatic spread. Overexpression of the EMT regulator Slug is detected in basal and mesenchymal-type TNBCs and is associated with reduced E-cadherin expression and aggressive disease. The effects of Slug depend, in part, on the interaction of its N-terminal SNAG repressor domain with the chromatin-modifying protein lysine demethylase 1 (LSD1; thus, we investigated whether tranylcypromine [also known as trans-2-phenylcyclopropylamine hydrochloride (PCPA or Parnate], an inhibitor of LSD1 that blocks its interaction with Slug, suppresses the migration, invasion, and metastatic spread of TNBC cell lines. We show here that PCPA treatment induces the expression of E-cadherin and other epithelial markers and markedly suppresses migration and invasion of TNBC cell lines MDA-MB-231 and BT-549. These effects were phenocopied by Slug or LSD1 silencing. In two models of orthotopic breast cancer, PCPA treatment reduced local tumor growth and the number of lung metastases. In mice injected directly in the blood circulation with MDA-MB-231 cells, PCPA treatment or Slug silencing markedly inhibited bone metastases but had no effect on lung infiltration. Thus, blocking Slug activity may suppress the metastatic spread of TNBC and, perhaps, specifically inhibit homing/colonization to the bone.

  4. Suppression of Invasion and Metastasis of Triple-Negative Breast Cancer Lines by Pharmacological or Genetic Inhibition of Slug Activity123

    Science.gov (United States)

    Ferrari-Amorotti, Giovanna; Chiodoni, Claudia; Shen, Fei; Cattelani, Sara; Soliera, Angela Rachele; Manzotti, Gloria; Grisendi, Giulia; Dominici, Massimo; Rivasi, Francesco; Colombo, Mario Paolo; Fatatis, Alessandro; Calabretta, Bruno

    2014-01-01

    Most triple-negative breast cancers (TNBCs) exhibit gene expression patterns associated with epithelial-to-mesenchymal transition (EMT), a feature that correlates with a propensity for metastatic spread. Overexpression of the EMT regulator Slug is detected in basal and mesenchymal-type TNBCs and is associated with reduced E-cadherin expression and aggressive disease. The effects of Slug depend, in part, on the interaction of its N-terminal SNAG repressor domain with the chromatin-modifying protein lysine demethylase 1 (LSD1); thus, we investigated whether tranylcypromine [also known as trans-2-phenylcyclopropylamine hydrochloride (PCPA) or Parnate], an inhibitor of LSD1 that blocks its interaction with Slug, suppresses the migration, invasion, and metastatic spread of TNBC cell lines. We show here that PCPA treatment induces the expression of E-cadherin and other epithelial markers and markedly suppresses migration and invasion of TNBC cell lines MDA-MB-231 and BT-549. These effects were phenocopied by Slug or LSD1 silencing. In two models of orthotopic breast cancer, PCPA treatment reduced local tumor growth and the number of lung metastases. In mice injected directly in the blood circulation with MDA-MB-231 cells, PCPA treatment or Slug silencing markedly inhibited bone metastases but had no effect on lung infiltration. Thus, blocking Slug activity may suppress the metastatic spread of TNBC and, perhaps, specifically inhibit homing/colonization to the bone. PMID:25499218

  5. Micellization behavior of mixtures of amphiphilic promazine hydrochloride and cationic aniline hydrochloride in aqueous and electrolyte solutions

    Energy Technology Data Exchange (ETDEWEB)

    Rub, Malik Abdul; Azum, Naved; Asiri, Abdullah M. [King Abdulaziz University, Jeddah (Saudi Arabia); Khan, Farah [Aligarh Muslim University, Aligarh (India); Al-Sehemi, Abdullah G. [Research Center for Advanced Materials Science, King Khalid University, Abha (Saudi Arabia)

    2015-10-15

    We studied the influence of cationic hydrotrope aniline hydrochloride on the micellization behavior of cationic amphiphilic phenothiazine drug promazine hydrochloride in the presence and absence of 50mmol kg{sup -1} NaCl. The experimental critical micelle concentration (CMC) values came out to be lower than ideal CMC (CMCid) values, signifying attractive interactions between the two components in mixed micelles. NaCl further decreases the CMC of pure PMZ and aniline hydrochloride as well as their mixture due to screening of the electrostatic repulsion among the polar head groups. The bulk properties of solution were examined by using different theoretical models for justification and comparison of results. The micellar mole fraction of aniline hydrochloride (X{sup Rub}{sub ,} X{sup M}{sub 1}, X{sup Rod}{sub 1} and X{sup id}{sub 1}) was evaluated by different proposed models, showing greater contribution of hydrotrope in mixed micelle. The negative values of interaction parameter (β) indicate synergistic interactions and negative values of β further decrease by the addition of salt in mixed systems. From the CMC values as a function of temperature, various thermodynamic properties have been evaluated and discussed in detail.

  6. Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics

    Science.gov (United States)

    Sharma, Deepak; Singh, Mankaran; Kumar, Dinesh; Singh, Gurmeet

    2014-01-01

    Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of Cetirizine Hydrochloride for allergic and respiratory disorders. As precision of dosing and patient's compliance become important prerequisite for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient's acceptability. Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of Cetirizine Hydrochloride which offers a new range of products having desired characteristics and intended benefits. Superdisintegrants such as Sodium Starch Glycolate were optimized. Different binders were optimized along with optimized superdisintegrant concentration. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content. Optimized formulation was evaluated by in vitro dissolution test, drug excipient compatibility and accelerated stability study. It was concluded that fast disintegrating tablets of Cetirizine Hydrochloride were formulated successfully with desired characteristics which disintegrated rapidly, provide rapid onset of action, and enhance the patient convenience and compliance. PMID:26556203

  7. Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics

    Directory of Open Access Journals (Sweden)

    Deepak Sharma

    2014-01-01

    Full Text Available Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of Cetirizine Hydrochloride for allergic and respiratory disorders. As precision of dosing and patient's compliance become important prerequisite for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient’s acceptability. Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of Cetirizine Hydrochloride which offers a new range of products having desired characteristics and intended benefits. Superdisintegrants such as Sodium Starch Glycolate were optimized. Different binders were optimized along with optimized superdisintegrant concentration. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content. Optimized formulation was evaluated by in vitro dissolution test, drug excipient compatibility and accelerated stability study. It was concluded that fast disintegrating tablets of Cetirizine Hydrochloride were formulated successfully with desired characteristics which disintegrated rapidly, provide rapid onset of action, and enhance the patient convenience and compliance.

  8. Charge-assisted bond N(+)H mediates the gelation of amorphous lurasidone hydrochloride during dissolution.

    Science.gov (United States)

    Qian, Shuai; Wang, Shanshan; Li, Zhen; Wang, Xiaojie; Ma, Di; Liang, Shujun; Gao, Yuan; Zhang, Jianjun; Wei, Yuanfeng

    2017-02-25

    Lurasidone hydrochloride (LH), the hydrochloride form of lurasidone with a charge-assisted bond N(+)H, is an atypical antipsychotropic agent for the treatment of schizophrenia. As a BCS class II drug, LH has a low oral bioavailability mainly due to its poor water solubility and low dissolution. In order to improve its solubility, amorphization of LH was performed and characterized. Unexpectedly, the dissolution rate of amorphous LH was much lower than that of crystalline LH. In addition, the amorphous LH powders quickly aggregated when contacting the dissolution media (water, 37°C), and formed a sticky gel adhering on the paddle. The follow-up polarized light microscope, XRPD, DSC, and FTIR analysis found that amorphous LH transformed to crystalline LH during dissolution. On the other hand, no such gelation phenomenon of amorphous lurasidone was observed under the same dissolution condition. However, the gel would reform when dropping concentrated hydrochloric acid slowly into the bottom of the medium during the dissolution of amorphous lurasidone, and XRPD/DSC/FTIR results indicated that the regenerated gel was consisted of crystalline LH, suggesting that the charge-assisted bond N(+)H in the structure of LH mediated the gel formation of amorphous LH during its dissolution process.

  9. Pharmacokinetics study of extended release formulations of buspirone hydrochloride in Beagle dogs

    Institute of Scientific and Technical Information of China (English)

    CUI Meng-cun; LI Jing-lai; CHEN Yan; WANG Xiao-ying; QIAO Jian-zhong; ZHANG Zhen-qing; RUAN Jin-xiu

    2008-01-01

    Objective To evaluate the pharmacokinetics (PK) properties of extended release formulations of buspirone hydrochloride in Beagle dogs. Methods A randomized, two period, two treatment, two sequence crossover bioequivalenee study was designed; six healthy Beagle dogs were randomly divided into two groups, each group was orally given buspirone tablets or buspirone extended capsule containing 15 mg buspirone hydrochloride. Blood samples (about 1 mL) were collected in heparinized tubes before dosing and at 0.33, 0.67, 1,2, 3, 4, 6, 8, 10, 12, 18, 24 h after administration, and were then immediately centrifuged at 3000 rpm for 15 min. The pharmacokinetics (PK) properties of the drugs were evaluated using the liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method. Results The mean tmax was 4.7, 0.8 h and Cmax values was 1.8, 6.9 μg·L-1, respectively for the sustained-release test (capsule) and reference formulation (tablet). When compared to the tablets, the residence time of the sustained capsules was dramatically prolonged and Cmax Was reduced (P<0.01). The initial release speed was slow and stable. The bioavailability was similar to the common tablets. Conclusions The sustained capsule had showed good pharmacokinetics property of sustained-release in the Beagle dogs.

  10. Ivabradine Hydrochloride (S-Mandelic Acid Co-Crystal: In Situ Preparation during Formulation

    Directory of Open Access Journals (Sweden)

    Veronika Sládková

    2017-01-01

    Full Text Available The pharmaceutical salt ivabradine hydrochloride is indicated for the symptomatic treatment of chronic stable angina pectoris and chronic heart failure. It exhibits extensive polymorphism and co-crystallization, which could be a way to provide an alternative solid form. We conducted a co-crystal screen, from which two hits were identified: with (S-mandelic and (R-mandelic acid. Both structures were determined from single-crystal X-ray diffraction data as co-crystals. The co-crystals were further characterized by common solid-state techniques, such as X-ray powder diffraction (XRPD, differential scanning calorimetry (DSC, solid-state NMR, IR and Raman spectroscopy, and dynamic vapor sorption (DVS. The co-crystal with (S-mandelic acid was selected for further development; its physical and chemical stability was compared with two different polymorphs of the hydrochloride salt. The co-crystal exhibited a similar stability with the polymorph used in the original drug product and was, therefore, selected for formulation into the drug product. During the pre-formulation experiments, the in situ formation of the co-crystal was achieved during the wet granulation process. The following formulation experiments showed no influence of in situ prepared co-crystal on the overall stability of the bulk, when compared with pre-prepared co-crystal formulation.

  11. 氟哌噻吨美利曲辛和盐酸帕罗西汀对乳腺癌患者化疗后焦虑抑郁情绪和生活质量影响的比较研究%Clinical effects and quality of life of flupentixol-melitracen compared with paroxetine hydrochloride in treatment of breast cancer patients with anxiety and depression after chemotherapy

    Institute of Scientific and Technical Information of China (English)

    张绪良; 周凯娜

    2015-01-01

    Objective To investigate the clinical effects and the quality of life of flupentixol-melitracen or paroxetine hydrochloride in treatment of the breast cancer patients with anxiety and depression after chemotherapy.Methods 135 breast cancer patients with anxiety and depression after chemotherapy were selected from November 2012 to January 2014 in the hospital.They were randomly divided into the treatment group ( n=68 ) and control group ( n =67 ).The control group were treated by paroxetine hydrochloride treatment, and the treatment group were treated by flupentixol-melitracen.The anxiety, depression and its impact on quality of life of patients were observed between two groups.Results After treatment, the HAMD score and HAMA score decreased significantly in two groups (P<0.05), HAMD score and HAMA score in treatment group after treatment significantly decreased compared with control group (P<0.05).After treatment, the WHOQOL-BREF score of mental health status scale of subjective feeling, the physiological domain, domain score levels in treatment group significantly increased (P<0.05), however, the quality of life of subjective feeling, social relationship and environment domains showed no significant difference.Compared with pre-treatment, only the health status of subjective feeling levels in control group post-treatment significantly increased (P<0.05).The mental health status scale of subjective feeling, the physiological domain, domain score levels in treatment group significantly decreased compared with control group ( P<0.05 ).The adverse reactions of treatment group were 5 cases (7.35%), which was significantly lower than 24 cases (35.82%) of control group(χ2 =16.22,P <0.05).Conclusion Flupentixol-melitracen combined with paroxetine hydrochloride has an obvious clinical effect in treatment of anxiety and depression in patients with breast cancer after chemotherapy.It could effectively control their anxiety and depression, and improve the quality of life of

  12. Sorptive removal of ciprofloxacin hydrochloride from simulated ...

    African Journals Online (AJOL)

    are effective in wastewater treatment (Budyanto et al., 2008). The resistant ... States and Europe (Bhandary et al., 2008). Although there ... applicable at an industrial scale, it is essential to exploit ...... and aerobic biological treatment process.

  13. In vitro assay of nuclear uptake of doxorubicin hydrochloride in osteosarcoma cells of dogs.

    Science.gov (United States)

    Weinstein, M J; Berg, J; Kusuzaki, K; Springfield, D S; Gebhardt, M C; Mankin, H J

    1991-12-01

    A rapid, simple chemosensitivity assay, assessing tumor cell nuclear uptake of doxorubicin hydrochloride, was evaluated in 16 dogs with appendicular osteosarcoma. Doxorubicin was administered to dogs in 5 biweekly treatments, and surgical resection was performed after the second or third treatment. The chemosensitivity assay was performed on biopsy specimens from all dogs before chemotherapy. It was repeated on tissue from resected tumors, and tumors were evaluated histologically to determine the degree of necrosis resulting from chemotherapy. Disease-free and total survival time correlated significantly (P less than 0.05 in both cases) with the degree of postchemotherapy necrosis of the primary tumors. Significant correlation was not apparent between the percentage of tumor cells with nuclear uptake of doxorubicin (in either biopsy or resection samples) and disease-free or total survival time. The percentage of cells with nuclear uptake of doxorubicin in surgically resected tumors correlated significantly (P less than 0.05) with percentage of necrosis.

  14. Radiographic assessment of nocturnal gastric juice secretion after administration of roxatidine acetate hydrochloride.

    Science.gov (United States)

    Tanioka, H; Terahara, A; Sasaki, Y

    1991-01-01

    Adult patients with symptoms of gastric disease were randomly assigned to a treatment group (n = 103) or untreated control group (n = 89). The treatment group received 75 mg of roxatidine acetate hydrochloride at 9 PM and 12 to 13 hours later gastric juice secretion was measured with gastric x-ray films in both groups. Mean gastric juice secretion was significantly lower in the treated group (16.1 ml/12 hrs) than in the untreated controls (49.8 ml/12 hrs). Gastric juice suppression by roxatidine was 90% in patients with gastric ulcer, 74% in patients with duodenal ulcer, 63% in patients with gastritis, and 70% in patients with no evidence of disease. It is concluded that 150 mg of roxatidine daily would be adequate to treat patients with gastric diseases.

  15. Comparison of the antiseptic efficacy of tissue-tolerable plasma and an octenidine hydrochloride-based wound antiseptic on human skin.

    Science.gov (United States)

    Lademann, J; Richter, H; Schanzer, S; Patzelt, A; Thiede, G; Kramer, A; Weltmann, K-D; Hartmann, B; Lange-Asschenfeldt, B

    2012-01-01

    Colonization and infection of wounds represent a major reason for the impairment of tissue repair. Recently, it has been reported that tissue-tolerable plasma (TTP) is highly efficient in the reduction of the bacterial load of the skin. In the present study, the antiseptic efficacy of TTP was compared to that of octenidine hydrochloride with 2-phenoxyethanol. Both antiseptic methods proved to be highly efficient. Cutaneous treatment of the skin with octenidine hydrochloride and 2-phenoxyethanol leads to a 99% elimination of the bacteria, and 74% elimination is achieved by TTP treatment. Technical challenges with an early prototype TTP device could be held responsible for the slightly reduced antiseptic properties of TTP, compared to a standard antiseptic solution, since the manual treatment of the skin surface with a small beam of the TTP device might have led to an incomplete coverage of the treated area. Copyright © 2012 S. Karger AG, Basel.

  16. Influence of prepartum pirlimycin hydrochloride or penicillin-novobiocin therapy on mastitis in heifers during early lactation.

    Science.gov (United States)

    Oliver, S P; Gillespie, B E; Ivey, S J; Lewis, M J; Johnson, D L; Lamar, K C; Moorehead, H; Dowlen, H H; Chester, S T; Hallberg, J W

    2004-06-01

    A study was conducted in 2 dairy research herds to determine whether prepartum therapy of heifer mammary glands with penicillin-novobiocin or pirlimycin hydrochloride was effective for reducing the percentage of heifers and mammary quarters infected with mastitis pathogens during early lactation. Almost 96% of Jersey heifers (67 of 70) and 71.3% of quarters (199 of 279) were infected 14 d before expected calving. Of the quarters infected at 14 d before expected parturition, 75% (54 of 72) were uninfected following treatment with penicillin-novobiocin; 87% (61 of 70) were uninfected following treatment with pirlimycin, and 56% (32 of 57) were uninfected in the untreated negative control group. The majority of intramammary infections in Jersey heifers were due to coagulase-negative staphylococci (61%), Streptococcus species, primarily Streptococcus uberis (19%), and Staphylococcus aureus (8%). Almost 73% of Holstein heifers (40 of 55) and 34.3% of mammary quarters (73 of 213) were infected 14 d before expected calving. Of the quarters infected at 14 d before expected parturition, 76% (19 of 25) were uninfected following treatment with penicillin-novobiocin; 59% (17 of 29) were uninfected following treatment with pirlimycin, and 26% (5 of 19) were uninfected in the untreated negative control group. The majority of intramammary infections in Holstein heifers were due to coagulase-negative staphylococci (44%) and Staph. aureus (30%). In both herds, the bacteriological cure rate was significantly higher in heifer mammary glands treated with penicillin-novobiocin or pirlimycin hydrochloride than in untreated controls. Prepartum therapy of heifer mammary glands with penicillin-novobiocin or pirlimycin hydrochloride significantly reduced the percentage of heifers and quarters infected with mastitis pathogens during early lactation.

  17. Effects of dobutamine hydrochloride on cardiovascular function in horses anesthetized with isoflurane with or without acepromazine maleate premedication.

    Science.gov (United States)

    Schier, Mara F; Raisis, Anthea L; Secombe, Cristy J; Hosgood, Giselle; Musk, Gabrielle C; Lester, Guy D

    2016-12-01

    OBJECTIVE To determine the effects of acepromazine maleate premedication on cardiovascular function before and after infusion of dobutamine hydrochloride for 30 minutes in isoflurane-anesthetized horses. ANIMALS 6 healthy adult horses. PROCEDURES Each horse was anesthetized once following premedication with acepromazine (0.02 mg/kg, IV) administered 30 minutes prior to anesthetic induction (ACP+ treatment) and once without premedication (ACP- treatment). Anesthesia was induced with IV administration of xylazine hydrochloride (0.8 mg/kg), ketamine hydrochloride (2.2 mg/kg), and diazepam (0.08 mg/kg). Horses were positioned in right lateral recumbency, and anesthesia was maintained via inhalation of isoflurane delivered in oxygen. End-tidal isoflurane concentration was adjusted to achieve a target mean arterial blood pressure of 60 mm Hg (interquartile range [25th to 75th percentile], 57 to 63 mm Hg) for at least 15 minutes. Cardiac index, oxygen delivery index, and femoral arterial blood flow indices were determined 60 minutes after anesthetic induction (baseline). Dobutamine was then infused to achieve a target mean arterial blood pressure of 80 mm Hg (interquartile range, 76 to 80 mm Hg). Data collection was repeated 30 minutes after the start of dobutamine infusion for comparison with baseline values. RESULTS Complete data sets were available from 5 of the 6 horses. Dobutamine administration resulted in significant increases in oxygen delivery and femoral arterial blood flow indices but no significant change in cardiac index for each treatment. However, at baseline or 30 minutes after the start of dobutamine infusion, findings for the ACP+ and ACP- treatments did not differ. CONCLUSIONS AND CLINICAL RELEVANCE In isoflurane-anesthetized horses, dobutamine administration increased oxygen delivery and femoral arterial blood flow indices, but these changes were unaffected by premedication with acepromazine.

  18. Fundamentals of ionic conductivity relaxation gained from study of procaine hydrochloride and procainamide hydrochloride at ambient and elevated pressure.

    Science.gov (United States)

    Wojnarowska, Z; Swiety-Pospiech, A; Grzybowska, K; Hawelek, L; Paluch, M; Ngai, K L

    2012-04-28

    The pharmaceuticals, procaine hydrochloride and procainamide hydrochloride, are glass-forming as well as ionically conducting materials. We have made dielectric measurements at ambient and elevated pressures to characterize the dynamics of the ion conductivity relaxation in these pharmaceuticals, and calorimetric measurements for the structural relaxation. Perhaps due to their special chemical and physical structures, novel features are found in the ionic conductivity relaxation of these pharmaceuticals. Data of conductivity relaxation in most ionic conductors when represented by the electric loss modulus usually show a single resolved peak in the electric modulus loss M(")(f) spectra. However, in procaine hydrochloride and procainamide hydrochloride we find in addition another resolved loss peak at higher frequencies over a temperature range spanning across T(g). The situation is analogous to many non-ionic glass-formers showing the presence of the structural α-relaxation together with the Johari-Goldstein (JG) β-relaxation. Naturally the analogy leads us to name the slower and faster processes resolved in procaine hydrochloride and procainamide hydrochloride as the primary α-conductivity relaxation and the secondary β-conductivity relaxation, respectively. The analogy of the β-conductivity relaxation in procaine HCl and procainamide HCl with JG β-relaxation in non-ionic glass-formers goes further by the finding that the β-conductivity is strongly related to the α-conductivity relaxation at temperatures above and below T(g). At elevated pressure but compensated by raising temperature to maintain α-conductivity relaxation time constant, the data show invariance of the ratio between the β- and the α-conductivity relaxation times to changes of thermodynamic condition. This property indicates that the β-conductivity relaxation has fundamental importance and is indispensable as the precursor of the α-conductivity relaxation, analogous to the relation found

  19. Disposable screen-printed sensors for determination of duloxetine hydrochloride

    Directory of Open Access Journals (Sweden)

    Alarfaj Nawal A

    2012-01-01

    Full Text Available Abstract A screen-printed disposable electrode system for the determination of duloxetine hydrochloride (DL was developed using screen-printing technology. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrodes was used as duloxetine hydrochloride sensor. The proposed sensors worked satisfactorily in the concentration range from 1.0 × 10-6-1.0 × 10-2 mol L-1 with detection limit reaching 5.0 × 10-7 mol L-1 and adequate shelf life of 6 months. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically by recovery studies.

  20. Thermal Analysis Applied to Verapamil Hydrochloride Characterization in Pharmaceutical Formulations

    Directory of Open Access Journals (Sweden)

    Maria Irene Yoshida

    2010-04-01

    Full Text Available Thermogravimetry (TG and differential scanning calorimetry (DSC are useful techniques that have been successfully applied in the pharmaceutical industry to reveal important information regarding the physicochemical properties of drug and excipient molecules such as polymorphism, stability, purity, formulation compatibility among others. Verapamil hydrochloride shows thermal stability up to 180 °C and melts at 146 °C, followed by total degradation. The drug is compatible with all the excipients evaluated. The drug showed degradation when subjected to oxidizing conditions, suggesting that the degradation product is 3,4-dimethoxybenzoic acid derived from alkyl side chain oxidation. Verapamil hydrochloride does not present the phenomenon of polymorphism under the conditions evaluated. Assessing the drug degradation kinetics, the drug had a shelf life (t90 of 56.7 years and a pharmaceutical formulation showed t90 of 6.8 years showing their high stability.

  1. Linear scleroderma after contusion and injection of mepivacaine hydrochloride.

    Science.gov (United States)

    Ueda, Takashi; Niiyama, Shiro; Amoh, Yasuyuki; Katsuoka, Kensei

    2010-05-15

    A 36-year-old woman initially was treated for a contusion by local injection of mepivacaine hydrochloride into the left dorsum of the foot. Approximately 3 months after the injury and injection, linear sclerotic plaques originating from the site of contusion and injection were recognized. These progressed in extent and severity over a period of 3 years, when she presented to our clinic. By biopsy, swelling of collagen fibers in the lower dermis was revealed and the condition was diagnosed as linear scleroderma. Our present case had multiple linear sclerotic plaques of the left lower extremity, the distribution of which was consistent with Blaschko lines. It was also revealed that the initial sclerotic plaque was at the site of the contusion and local mepivacaine hydrochloride injection. Our present case is interesting in that the findings suggest a correlation between linear scleroderma plaque occurrence and the contusion or injection of mepivacaine.

  2. Synthesis of /sup 14/C-Bucromarone succinate and hydrochloride

    Energy Technology Data Exchange (ETDEWEB)

    Nicolas, C.; Verny, M.; Maurizis, J.-C.; Payard, M.; Faurie, M.

    1986-08-01

    /sup 14/C-Bucromarone, 2-(4-(3-N,N dibutylamino propoxy) 3,5-dimethyl benzoyl) chromone, was synthesized from (U-/sup 14/C) oxalic acid. The labelling takes place at the first step of the synthesis, giving /sup 14/C-Bucromarone succinate (specific activity 7.45 mCi/mmol) and /sup 14/C-Bucromarone hydrochloride (specific activity 7.5 mCi/mmol).

  3. Enantiospecific synthesis of (1- sup 3 H)-(+)-pseudoephedrine hydrochloride

    Energy Technology Data Exchange (ETDEWEB)

    Hill, J.A.; Scharver, J.D. (Burroughs Wellcome Co., Research Triangle Park, North Carolina (USA). Chemical Development Labs.)

    1990-06-01

    The naturally occurring dextrorotary enantiomer (+)-pseudoephedrine was synthesized in the ({sup 3}H)-labelled form with specific activity 17.5 Ci/mmol suitable for development of a radioimmunoassay procedure. The chirally specific route from L-alanine to (1-{sup 3}H)-d-pseudoephedrine hydrochloride was based on the use of {alpha}-amino acids as chiral educts for asymmetric products. (author).

  4. OPTIMIZATION OF CONCENTRATION OF POLYHEXANIDE HYDROCHLORIDE IN MULTIPURPOSE SOLUTION.

    OpenAIRE

    Arora, A.; Ali, A.; M.T.Zzaman; Chauhan, S.; V.Handa

    2010-01-01

    There are a number of foreign pathogenic microorganisms like viruses, bacteria, yeast, fungi and protozoa which can inadvertently be introduced into eye via contact lens and hence disinfection is a vital part. Multifunctional solutions are generally intended to combine the action of cleaning disinfecting, rinsing lubricating deproteinising and soaking in one single product.In order to optimization of concentration of Polyhexanide hydrochloride in multipurpose solution some microbiological stu...

  5. FORMULATION AND EVALUATION OF FLOATING TABLETS OF TIZANIDINE HYDROCHLORIDE

    Directory of Open Access Journals (Sweden)

    Adimoolam Senthil

    2011-08-01

    Full Text Available The objective of the present investigation was to develop floating matrix tablets of tizanidine hydrochloride for prolongation of gastric residence time in order to overcome its low bioavailability (34–40% and short biological half life (4.2 h. Tizanidine hydrochloride floating tablets were prepared by the direct compression method, using different viscosity grades of hydroxypropylmethylcellulose (HPMC K4M and K15M. Tizanidine hydrochloride is an orally administered prokinetic agent that facilitates or restores motility throughout the length of the gastrointestinal tract. Tablets were evaluated for various physical parameters and floating properties. Further, tablets were studied for in-vitro drug release characteristics in 12 hours. Drug release from floating matrix tablets was sustained over 12 h with buoyant properties. DSC study revealed that there was no drug and excipient interaction. Based on the release kinetics, all formulations best fitted the Higuchi, first-order model and non-Fickian as the mechanism of drug release. The optimized formulation (F9 released 75% of drug at the end of 10 hours by in-vitro release study.

  6. A novel kind of TSV slurry with guanidine hydrochloride

    Science.gov (United States)

    Jiao, Hong; Yuling, Liu; Baoguo, Zhang; Xinhuan, Niu; Liying, Han

    2015-10-01

    The effect of a novel alkaline TSV (through-silicon-via) slurry with guanidine hydrochloride (GH) on CMP (chemical mechanical polishing) was investigated. The novel alkaline TSV slurry was free of any inhibitors. During the polishing process, the guanidine hydrochloride serves as an effective surface-complexing agent for TSV CMP applications, the removal rate of barrier (Ti) can be chemically controlled through tuned selectivity with respect to the removal rate of copper and dielectric, which is helpful to modifying the dishing and gaining an excellent topography performance in TSV manufacturing. In this paper, we mainly studied the working mechanism of the components of slurry and the skillful application guanidine hydrochloride in the TSV slurry. Project supported by the Major National Science and Technology Special Projects (No. 2009ZX02308), the Fund Project of Hebei Provincial Department of Education, China (No. QN2014208), the Natural Science Foundation of Hebei Province, China (No. E2013202247), and Colleges and Universities Scientific research project of Hebei Province, China (No. Z2014088).

  7. Spectrophotometric estimation of betahistine hydrochloride in tablet formulations

    Directory of Open Access Journals (Sweden)

    Amit Kumar

    2010-01-01

    Full Text Available Aim: The study aims to develop simple, sensitive, rapid, accurate and precise spectrophotometric method for estimation of Betahistine hydrochloride in tablet dosage forms. Materials and Methods: For method I and II, in a series of 10 ml volumetric flask, aliquots of standard drug solution (100 μg/ml in double distilled water were transferred and diluted with same so as to give several dilutions in concentration range of 15-90 μg/ml and 10-80 μg/ml respectively of betahistine hydrochloride. To 5 ml of each dilution taken in a separating funnel, (5 ml of methyl orange for method I and 5 ml of bromo phenol blue for method II reagent and 5 ml of chloroform was added. Reaction mixture was shaken gently for 5 min and allowed to stand so as to separate aqueous and chloroform layer. Absorbance maxima measured at 421.6 nm and 412 nm for method I and II respectively. Results: The recovery studies were found close to 100 % that indicates accuracy and precision of the proposed methods. The statistical analysis was carried out and results of which were found satisfactory. Standard deviation values were found low that indicated reproducibility of the proposed methods. Conclusion: Based on results the developed methods could be used for routine estimation of betahistine hydrochloride from tablet formulations.

  8. 21 CFR 520.222 - Bunamidine hydrochloride.

    Science.gov (United States)

    2010-04-01

    ... Taenia taeniaeformis. (2) It is administered to cats and dogs at the rate of 25 to 50 milligrams per... oral administration to dogs for the treatment of the tapeworms Dipylidium caninum, Taenia...

  9. Use of xylazine hydrochloride-ketamine hydrochloride for immobilization of wild leopards (Panthera pardus fusca) in emergency situations.

    Science.gov (United States)

    Belsare, Aniruddha V; Athreya, Vidya R

    2010-06-01

    In India, leopards (Panthera pardus fusca) inhabit human-dominated landscapes, resulting in encounters that require interventions to prevent harm to people, as well as the leopards. Immobilization is a prerequisite for any such intervention. Such emergency field immobilizations have to be carried out with limited tools, often amidst large uncontrollable crowds. An effective and practicable approach is discussed, based on 55 wild leopard immobilizations undertaken between January 2003 and April 2008. A xylazine hydrochloride (1.4 +/- 0.3 mg/kg)--ketamine hydrochloride (5 +/- 2 mg/kg) mixture was used for immobilization of leopards, based on estimated body weight. When weight could not be estimated, a standard initial dose of 50 mg of xylazine--150 mg of ketamine was used. Supplemental doses (50-75 mg) of only ketamine were used as required. No life-threatening adverse effects of immobilization were documented for at least 1 mo postimmobilization.

  10. A validated stability-indicating high performance liquid chromatographic method for moxifloxacin hydrochloride and ketorolac tromethamine eye drops and its application in pH dependent degradation kinetics

    Directory of Open Access Journals (Sweden)

    Jayant B Dave

    2013-01-01

    Full Text Available Background and Aim: A fixed dose combination of moxifloxacin hydrochloride and ketorolac tromethamine is used in ratio of 1:1 as eye drops for the treatment of the reduction of post operative inflammatory conditions of the eye. A simple, precise, and accurate High Performance Liquid Chromatographic (HPLC method was developed and validated for determination of moxifloxacin hydrochloride and ketorolac tromethamine in eye drops. Materials and Methods: Isocratic HPLC separation was achieved on a ACE C 18 column (C 18 (5 μm, 150 mm×4.6 mm, i.d. using the mobile phase 10 mM potassium di-hydrogen phosphate buffer pH 4.6-Acetonitrile (75:25 v/v at a flow rate of 1.0 mL/min. The detection was performed at 307 nm. Drugs were subjected to acid, alkali and neutral hydrolysis, oxidation and photo degradation. Moreover, the proposed HPLC method was utilized to investigate the pH dependent degradation kinetics of moxifloxacin hydrochloride and ketorolac tromethamine in buffer solutions at different pH values like 2.0, 6.8 and 9.0. Results and Conclusion: The retention time (t R of moxifloxacin hydrochloride and ketorolac tromethamine were 3.81±0.01 and 8.82±0.02 min, respectively. The method was linear in the concentration range of 2-20 μ/mL each for moxifloxacin hydrochloride and ketorolac tromethamine with a correlation coefficient of 0.9996 and 0.9999, respectively. The method was validated for linearity, precision, accuracy, robustness, specificity, limit of detection and limit of quantitation. The drugs could be effectively separated from different degradation products and hence the method can be used for stability analysis. Different kinetics parameters like apparent first-order rate constant, half-life and t 90 (time for 90% potency left were calculated.

  11. Bioadhesive ranitidine hydrochloride for gastroretention with controlled microenvironmental pH.

    Science.gov (United States)

    Adhikary, Anuradha; Vavia, Pradeep R

    2008-08-01

    Ranitidine hydrochloride is a H(2) receptor blocker used in the treatment of gastric ulcers. Pharmacological factors, in addition to the dosage regimen, favor development of a sustained-release system for ranitidine especially in the therapeutic condition of erosive esophagitis. This investigation delves into the development of bioadhesive type of gastroretentive formulation (tablets) of ranitidine. The effect of mucoadhesive polymers such as Carbopol, hydroxypropyl methyl cellulose, and dextrose were studied. Mucoadhesion, in vitro drug release profile, water uptake, and swelling of the tablet were evaluated. Alkalizing agents were incorporated in an attempt to maintain an alkaline microenvironment within the tablet and improve the stability of the drug in acidic medium. The stability was evaluated using dye test and degradation studies. The drug release profiles were fit into various kinetic models.

  12. Simultaneous determination of paracetamol, phenylephrine hydrochloride and chlorpheniramine maleate in pharmaceutical preparations using multivariate calibration 1

    Science.gov (United States)

    Samadi-Maybodi, Abdolraouf; Hassani Nejad-Darzi, Seyed Karim

    2010-04-01

    Resolution of binary mixtures of paracetamol, phenylephrine hydrochloride and chlorpheniramine maleate with minimum sample pre-treatment and without analyte separation has been successfully achieved by methods of partial least squares algorithm with one dependent variable, principal component regression and hybrid linear analysis. Data of analysis were obtained from UV-vis spectra of the above compounds. The method of central composite design was used in the ranges of 1-15 mg L -1 for both calibration and validation sets. The models refinement procedure and their validation were performed by cross-validation. Figures of merit such as selectivity, sensitivity, analytical sensitivity and limit of detection were determined for all three compounds. The procedure was successfully applied to simultaneous determination of the above compounds in pharmaceutical tablets.

  13. Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs

    Directory of Open Access Journals (Sweden)

    Saburo Minami

    2012-08-01

    Full Text Available D-Glucosamine hydrochloride (GlcN∙HCl is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fumarate respiration and elevated plasma levels of lactic acid and alanine were observed after administration. These results suggest that oral administration of GlcN∙HCl induces anaerobic respiration and starvation in cells, and we hypothesize that these conditions promote cartilage regeneration. Further studies are required to evaluate the expression of transforming growth factor-beta (TGF-β.

  14. A high-sensitivity terahertz spectroscopy technology for tetracycline hydrochloride detection using metamaterials.

    Science.gov (United States)

    Qin, Jianyuan; Xie, Lijuan; Ying, Yibin

    2016-11-15

    Antibiotic residues in animal-derived food due to their overuse in veterinary medicine will have potential adverse effects on human health. The rapid and accurate detection of these drugs is essential for ensuring human food safety. In particular, the current detection methods are usually limited by the low sensitivity or the tedious pre-treatment. Here we demonstrate that metamaterials operating at terahertz frequencies, acting as highly sensitive sensors, show promising potential for the detection of tetracycline hydrochloride (TCH). We were able to detect a trace amount of TCH, as small as 0.1mg/L, which was about 10(5) times enhancement compared to the measurement of TCH on a silicon substance. Our study is likely to constitute an important step toward the detection of antibiotic residues in a food matrix. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. The 14-day repeated dose liver micronucleus test with methapyrilene hydrochloride using young adult rats.

    Science.gov (United States)

    Inoue, Kenji; Ochi, Akimu; Koda, Akira; Wako, Yumi; Kawasako, Kazufumi; Doi, Takaaki

    2015-03-01

    The repeated dose liver micronucleus (RDLMN) assay using young adult rats has the potential to detect genotoxic hepatocarcinogens that can be integrated into a general toxicity study. The assay methods were thoroughly validated by 19 Japanese facilities. Methapyrilene hydrochloride (MP), known to be a non-genotoxic hepatocarcinogen, was examined in the present study. MP was dosed orally at 10, 30 and 100mg/kg/day to 6-week-old male Crl:CD (SD) rats daily for 14 days. Treatment with MP resulted in an increase in micronucleated hepatocytes (MNHEPs) with a dosage of only 100mg/kg/day. At this dose level, cytotoxicity followed by regenerative cell growth was noted in the liver. These findings suggest that MP may induce clastogenic effects indirectly on the liver or hepatotoxicity of MP followed by regeneration may cause increase in spontaneous incidence of MNHEPs.

  16. Interaction between lidocaine hydrochloride (with and without adrenaline) and various irrigants: A nuclear magnetic resonance analysis

    Science.gov (United States)

    Vidhya, Nirmal; Karthikeyan, Balasubramanian Saravana; Velmurugan, Natanasabapathy; Abarajithan, Mohan; Nithyanandan, Sivasankaran

    2014-01-01

    Background: Interaction between local anesthetic solution, lidocaine hydrochloride (with and without adrenaline), and root canal irrigants such as sodium hypochlorite (NaOCl), ethylene diamine tetra-acetic acid (EDTA), and chlorhexidine (CHX) has not been studied earlier. Hence, the purpose of this in vitro study was to evaluate the chemical interaction between 2% lidocaine hydrochloride (with and without adrenaline) and commonly used root canal irrigants, NaOCl, EDTA, and CHX. Materials and Methods: Samples were divided into eight experimental groups: Group I-Lidocaine hydrochloride (with adrenaline)/3% NaOCl, Group II-Lidocaine hydrochloride (with adrenaline)/17% EDTA, Group III- Lidocaine hydrochloride (with adrenaline)/2% CHX, Group IV-Lidocaine hydrochloride (without adrenaline)/3% NaOCl, Group V-Lidocaine hydrochloride (without adrenaline)/17% EDTA, Group VI-Lidocaine hydrochloride (without adrenaline)/2% CHX, and two control groups: Group VII-Lidocaine hydrochloride (with adrenaline)/deionized water and Group VIII-Lidocaine hydrochloride (without adrenaline)/deionized water. The respective solutions of various groups were mixed in equal proportions (1 ml each) and observed for precipitate formation. Chemical composition of the formed precipitate was then analysed by nuclear magnetic resonance spectroscopy (NMR) and confirmed with diazotation test. Results: In groups I and IV, a white precipitate was observed in all the samples on mixing the respective solutions, which showed a color change to reddish brown after 15 minutes. This precipitate was then analysed by NMR spectroscopy and was observed to be 2,6-xylidine, a reported toxic compound. The experimental groups II, III, V, and VI and control groups VII and VIII showed no precipitate formation in any of the respective samples, until 2 hours. Conclusion: Interaction between lidocaine hydrochloride (with and without adrenaline) and NaOCl showed precipitate formation containing 2,6-xylidine, a toxic compound

  17. Stability of ranitidine hydrochloride and amino acids in parenteral nutrient solutions.

    Science.gov (United States)

    Bullock, L; Parks, R B; Lampasona, V; Mullins, R E

    1985-12-01

    The stability of ranitidine hydrochloride in parenteral nutrient (PN) solutions and the effect of ranitidine hydrochloride on the amino acids in the PN solutions were studied. Six PN solutions (three each with amino acid contents of 2.125 and 4.25%) were prepared. Each PN solution also contained dextrose 25%, electrolytes, trace elements, vitamins, and heparin sodium. Ranitidine hydrochloride injection was added to four of the PN samples. Of the final samples, two contained no ranitidine, two contained ranitidine hydrochloride 50 micrograms/mL, and two contained ranitidine hydrochloride 100 micrograms/mL. Admixtures of ranitidine hydrochloride at the two concentrations in 0.9% sodium chloride injection were also prepared. Samples were observed for color change and tested for pH during storage at room temperature. Concentrations of amino acids were measured after 24 hours in samples without ranitidine and in samples containing ranitidine hydrochloride 100 micrograms/mL. Ranitidine hydrochloride content was determined by high-performance liquid chromatography at 12, 24, and 48 hours. No visual changes or pH changes occurred by 24 hours. All PN solutions became darker by 48 hours. The presence of ranitidine hydrochloride did not substantially affect amino acid concentrations. At 24 hours, at least 90% of the initial ranitidine concentrations remained in all samples. In three of the four PN samples at 48 hours, less than 90% of initial ranitidine concentrations remained. Ranitidine hydrochloride in concentrations of 50 and 100 micrograms/mL in parenteral nutrient solutions containing 4.25 and 2.125% crystalline amino acids is stable for 24 hours at room temperature. Under these conditions, concentrations of the amino acids contained in the PN solutions were not affected by the addition of ranitidine hydrochloride.

  18. High-performance liquid chromatographic determination of memantine hydrochloride in rat plasma using sensitive fluorometric derivatization.

    Science.gov (United States)

    Xie, Mei-Fen; Zhou, Wei; Tong, Xin-Yi; Chen, Yi-Le; Cai, Yi; Li, Yan; Duan, Geng-Li

    2011-02-01

    In this study, we investigated a simple, sensitive and reliable liquid chromatography-fluorescence detection method for the determination of memantine hydrochloride in rat plasma which was based on derivatization with 9-fluorenylmethyl chloroformate (FMOC-Cl). For the first time, FMOC-Cl was introduced into derivatization of memantine hydrochloride in rat plasma. The amino groups of memantine hydrochloride and amantadine hydrochloride (internal standard) were trapped with FMOC-Cl to form memantine hydrochloride-FMOC-Cl and amantadine hydrochloride-FMOC-Cl compositions, which can be very compatible for LC-FLD. Precipitation of plasma proteins by acetonitrile was followed by vortex mixing and centrifugation. Chromatographic separation was performed on a C(18) column (DIAMONSIL 150 × 4.6 mm, id 5 μm) with a mobile phase consisting of acetonitrile and water at a flow rate of 1.0 mL/min. The retention times of memantine hydrochloride-FMOC-Cl and amantadine hydrochloride-FMOC-Cl compositions were 23.69 and 40.27 min, respectively. Optimal conditions for the derivatization of memantine hydrochloride were also described. The limit of quantification (LOQ) was 25 ng/mL for memantine hydrochloride in plasma, the linear range was 0.025-5.0 μg/mL in plasma with a correlation coefficient (r) of 0.9999. The relative standard deviations (RSDs) of intra-day and inter-day assays were 4.46-12.19 and 5.23-11.50%, respectively. The validated method was successfully applied to the determination of memantine hydrochloride in rat plasma samples.

  19. Clinical assessment of the warming sensation accompanying flavor 316282 in a cold and cough syrup containing paracetamol, phenylephrine hydrochloride, and guaifenesin

    OpenAIRE

    Rowland Furcha; Joëlle Monnet

    2014-01-01

    Objective: The primary objective was to assess the warming sensation caused by flavor 316282 in a cold and cough product in the target population. Methods: A single-cohort, single-treatment arm, open-label study. Subjects received one 30-mL dose of syrup containing flavor 316282, paracetamol, phenylephrine hydrochloride, and guaifenesin and recorded onset and disappearance of any warming sensation in the mouth/throat. Subjects’ assessment of strength and appeal of the sensation, taste, textur...

  20. Therapeutic class-specific signal detection of bradycardia associated with propranolol hydrochloride

    Directory of Open Access Journals (Sweden)

    Gavali Dhaval

    2009-01-01

    Full Text Available Background: Propranolol hydrochloride, one of the most widely used β-blocker in the treatment of hypertension since 1960s, shows a number of serious and non-serious adverse events. Objective: Major objectives of this study were to extract the Canadian Adverse Drug Reaction Monitoring Program (CADRMP database for possible toxic signal detection (SD of propranolol hydrochloride, evaluate the frequency of the bradycardia associated with it in different stratified groups for a putative signal, and generate awareness in healthcare professionals regarding usefulness of SD. Materials and Methods: Appropriate statistical methods were used for adverse drug reaction (ADR signal detection such as, proportional reporting ratio (PRR; reporting odds ratio (ROR; the Chi-square (λ2 statistic method; the 95% confidence interval (CI; the observed to expected ratio (O/E; and Du Mouchel method were used to calculate the possible signals. Significance of λ2 and other calculated statistics, e.g., PRR and ROR, was based on a composite criterion of regulatory guidelines and not on any particular statistical level of significance. Results: Calculated statistics by different methods were compared with the regulatory criteria of a statistic value ≥4.0 for λ2 , and ≥3.0 for the rest for SD to be declared significant. The PRR statistic was found to be 2.5054; by the ROR method it was 2.5820; the λ2 statistic was 3.2598, whereas the lower and upper limits of 95% CI of PRR were found to be 0.0778 and 1.9104, respectively, by the O/E ratio was found to be 2.3978, and PRR with the help of Du Mouchel was found to be 2.3979. Thus, the bradycardia-propranolol signals calculated in this study were not significant. Conclusions: The therapeutic class specific signal of bradycardia associated with propranolol hydrochloride was not found potent enough to cause bradycardia. However, since the calculated statistics were very high albeit not significant, the possibility of

  1. 78 FR 27971 - Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not...

    Science.gov (United States)

    2013-05-13

    ... HUMAN SERVICES Food and Drug Administration Determination That REV-EYES (Dapiprazole Hydrochloride... determined that REV-EYES (dapiprazole hydrochloride ophthalmic solution), 0.5%, was not withdrawn from sale... refer to a listed drug. REV-EYES (dapiprazole hydrochloride ophthalmic solution), 0.5%, is the...

  2. 21 CFR 520.1242b - Levamisole hydrochloride tablet or oblet (bolus).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Levamisole hydrochloride tablet or oblet (bolus). 520.1242b Section 520.1242b Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1242b Levamisole hydrochloride tablet...

  3. 21 CFR 520.1242c - Levamisole hydrochloride and piperazine dihydrochloride.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Levamisole hydrochloride and piperazine dihydrochloride. 520.1242c Section 520.1242c Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.1242c Levamisole hydrochloride...

  4. A practical synthesis of sarpogrelate hydrochloride and in vitro platelet aggregation inhibitory activities of its analogues

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    A convenient approach for the preparation of sarpogrelate hydrochloride was developed.Two series of sarpogrelate hydrochloride analogues were designed and synthesized in order to improve their platelet aggregation inhibitory activities, biological tests suggested that these compounds have platelet aggregation inhibitory activities to some extent.

  5. 40 CFR Appendix B to Subpart Nnn... - Free Formaldehyde Analysis of Insulation Resins by Hydroxylamine Hydrochloride

    Science.gov (United States)

    2010-07-01

    ... Insulation Resins by Hydroxylamine Hydrochloride B Appendix B to Subpart NNN of Part 63 Protection of...—Free Formaldehyde Analysis of Insulation Resins by Hydroxylamine Hydrochloride 1. Scope This method was specifically developed for water-soluble phenolic resins that have a relatively high free-formaldehyde...

  6. Sixty-three Cases of Prevention of Gastrointestinal Side Effects Caused by Chemotherapeutic Agents by Palonosetron Hydrochloride%盐酸帕洛诺司琼预防化疗药物所致胃肠道反应63例

    Institute of Scientific and Technical Information of China (English)

    张珺; 梁亚军

    2011-01-01

    Objective To compare the efficacy and safety of palonosetron hydrochloride and tropisetron hydrochloride on prevention of gastrointestinal side effects caused by chemotherapeutic drugs. Methods Patients were randomly divided into 2 groups by self-cross comparison: AB group (palonosetron hydrochloride was given in the first cycle and tropisetron hydrochloride in the second ) and BA group ( the treatment was in an opposite way ). Results A total 63 patients were evaluable. The amelioration of anorexia, nausea and vomiting were similar in both groups, 0-24 hours after treatment. The inhibition of anorexia, nausea and vomiting in the palonosetron hydrochloride group was significantly obvious than that in the tropisetron hydrochloride treated group,24-120 hours and 0-120 hours after the treatment,( P<0.05 ). The most common adverse event was headache for these drugs. Conclusion Palonosetron hydrochloride is more effective on delaying nausea and vomiting than tropisetron hydrochloride and with few side effects,which is worth for the clinic use.%目的 观察盐酸帕洛诺司琼预防化疗药物所致胃肠道反应的疗效和安全性,并与盐酸托烷司琼进行对比.方法 采用随机自身交叉对照,63例入选患者分为AB组32例和BA组31例,AB组第1周期应用盐酸帕洛诺司琼,第2周期应用盐酸托烷司琼;BA组则相反.结果 可评价患者63例,化疗后0~24 h盐酸帕洛诺司琼和盐酸托烷司琼对化疗引起的食欲不振、恶心和呕吐的有效率相似,在24~120 h和0~120 h,盐酸帕洛诺司琼对化疗引起的食欲不振、恶心和呕吐的有效率优于盐酸托烷司琼,差异有统计学意义(P<0.05).两药的不良反应相似,主要为头痛和便秘.结论 盐酸帕洛诺司琼对延迟性恶心呕吐的有效性优于盐酸托烷司琼,值得临床推广应用.

  7. Human pharmacokinetics of the muscle relaxant, eperisone hydrochloride by liquid chromatography-electrospray tandem mass spectrometry.

    Science.gov (United States)

    Melilli, Barbara; Piazza, Cateno; Vitale, Daniela Cristina; Marano, Maria Rosa; Pecori, Andrea; Mattana, Paolo; Volsi, Valentina Li; Iuculano, Carmelo; Cardì, Francesco; Drago, Filippo

    2011-06-01

    Eperisone hydrochloride (4'-ethyl-2-methyl-3-piperidinopropiophenone hydrochloride) is a muscle relaxant agent, widely used in the treatment of patients with muscular contractures, low back pain or spasticity. Because of its mechanism of action (inhibition of gamma-efferent firing and local vasodilatation activity), side effects on central nervous system are rarely observed. A sensitive liquid chromatography-electrospray ionization-mass spectrometry method for determination of eperisone in human plasma has been developed, with a lower limit of quantification of 0.01 ng/mL. The method was applied to a pharmacokinetic study in 12 healthy volunteers given eperisone 100 mg as single dose on day 1 and three times daily on days 2 to 4. Eperisone was rapidly absorbed after oral administration (T (max) = 1.6 h) as it was expected by its fast-onset relaxant activity. Moreover, eperisone underwent a rapid elimination from the body (biological half-life 1.87 h), which was not modified during the repeated dosing as suggested by the C (max) cumulation observed, not different from that expected for a t (1/2) of 1.87 h as suggested by the similar and negligible plasma concentration values (0.063 and 0.067 ng/mL) measured on day 4 before the morning dose and 12 h after evening dose, thus ruling out any potential risk for drug accumulation. Thus, the pharmacokinetic characteristics of eperisone provide further justification for its tolerability in patients with low back pain or spastic palsy, in which the drug is given for periods ranging from few days to several months, respectively.

  8. Neuroprotection against vascular dementia after acupuncture combined with donepezil hydrochloride: P300 event related potential

    Directory of Open Access Journals (Sweden)

    Qiang Liu

    2016-01-01

    Full Text Available Acupuncture can be used to treat various nervous system diseases. Here, 168 vascular dementia patients were orally administered donepezil hydrochloride alone (5 mg/day, once a day for 56 days, or combined with acupuncture at Shenting (DU24, Tianzhu (BL10, Sishencong (Extra, Yintang (Extra, Renzhong (DU26, Neiguan (PC6, Shenmen (HT7, Fengchi (GB20, Wangu (GB12 and Baihui (DU20 (once a day for 56 days. Compared with donepezil hydrochloride alone, P300 event related potential latency was shorter with an increased amplitude in patients treated with donepezil hydrochloride and acupuncture. Mini-Mental State Examination score was also higher. Moreover, these differences in P300 latency were identified within different infarcted regions in patients treated with donepezil hydrochloride and acupuncture. These findings indicate that acupuncture combined with donepezil hydrochloride noticeably improves cognitive function in patients with vascular dementia, and exerts neuroprotective effects against vascular dementia.

  9. Neuroprotection against vascular dementia after acupuncture combined with donepezil hydrochloride:P300 event related potential

    Institute of Scientific and Technical Information of China (English)

    Qiang Liu; Xiu-juan Wang; Zhe-cheng Zhang; Rong Xue; Ping Li; Bo Li

    2016-01-01

    Acupuncture can be used to treat various nervous system diseases. Here, 168 vascular dementia patients were orally administered donepezil hydrochloride alone (5 mg/day, once a day for 56 days), or combined with acupuncture atShenting (DU24),Tianzhu (BL10),Sishencong (Extra), Yintang (Extra),Renzhong (DU26),Neiguan (PC6),Shenmen (HT7),Fengchi (GB20),Wangu (GB12) andBaihui (DU20) (once a day for 56 days). Compared with donepezil hydrochloride alone, P300 event related potential latency was shorter with an increased ampli-tude in patients treated with donepezil hydrochloride and acupuncture. Mini-Mental State Examination score was also higher. Moreover, these differences in P300 latency were identiifed within different infarcted regions in patients treated with donepezil hydrochloride and acupuncture. These ifndings indicate that acupuncture combined with donepezil hydrochloride noticeably improves cognitive function in patients with vascular dementia, and exerts neuroprotective effects against vascular dementia.

  10. Liquid Chromatographic Methods for the Determination of Vildagliptin in the Presence of its Synthetic Intermediate and the Simultaneous Determination of Pioglitazone Hydrochloride and Metformin Hydrochloride

    OpenAIRE

    El-Bagary, Ramzia I.; Elkady, Ehab F.; Ayoub, Bassam M.

    2011-01-01

    Two reversed-phase liquid chromatographic (RP-LC) methods are described for the determination of two binary mixtures of hypoglycemic agents. In the first method, vildagliptin (VDG) was determined in the presence of 3-amino-1-adamantanol (AAD), a synthetic intermediate and impurity of VDG. In the second method, pioglitazone hydrochloride (PGZ) and metformin hydrochloride (MET) were simultaneously determined in their binary mixture. Chromatographic separation in the two methods was achieved on ...

  11. Verapamil hydrochloride release characteristics from new copolymer zwitterionic matrix tablets.

    Science.gov (United States)

    Kostova, Bistra; Kamenska, Elena; Ivanov, Ivo; Momekov, George; Rachev, Dimitar; Georgiev, George

    2008-01-01

    The aim of this study was to synthesize stable copolymer (vinyl acetate-co-3-dimethyl[methacryloyloxyethyl] ammonium propane sulfinate) zwitterionic latex with different compositions for the first time by emulsifier-free emulsion copolymerization. Throughout the course of the study, a proposal was made for the explanation of the relationship between the "overshooting" phenomenon (a swelling kinetics with a maximum) and the specific self-association of the zwitterionic copolymers. The zwitterionic monomer unit mole fraction, pH, and ionic strength effects on this relationship, on the swelling kinetics of the zwitterionic copolymers, and on the sustained verapamil hydrochloride release from the model tablets were established by the study's authors.

  12. EVALUATION OF THE THERAPEUTIC EFFICACY OF LEVAMISOLE HYDROCHLORIDE ON THIRD-STAGE LARVAE OF Lagochilascaris minor IN EXPERIMENTALLY INFECTED MICE

    Directory of Open Access Journals (Sweden)

    Dulcinéa Maria Barbosa CAMPOS

    2016-01-01

    Full Text Available Lagochilascariosis, a disease caused by Lagochilascaris minor, affects the neck, sinuses, tonsils, lungs, the sacral region, dental alveoli, eyeballs and the central nervous system of humans. A cycle of autoinfection may occur in human host tissues characterized by the presence of eggs, larvae and adult worms. This peculiarity of the cycle hinders therapy, since there are no drugs that exhibit ovicidal, larvicidal and vermicidal activity. Given these facts, we studied the action of levamisole hydrochloride on third-stage larvae in the migration phase (G1 and on encysted larvae (G3 of L. minor. To this end, 87 inbred mice of the C57BL/6 strain were divided into test groups comprising 67 animals (G1-37; G3-30 and a control group (G2-10; G4-10 with 20 animals. Each animal was inoculated orally with 2,000 infective eggs of the parasite. The animals of the test groups were treated individually with a single oral dose of levamisole hydrochloride at a concentration of 0.075 mg. The drug was administered either 30 minutes prior to the parasite inoculation (G1 animals or 120 days after the inoculation (G3 animals. The mice in the control groups were not treated with the drug. After the time required for the migration and the encysting of L. minor larvae, all the animals were euthanized and their tissues examined. The data were analyzed using the Student's unpaired t-test and the Levene test. The groups showed no statistically significant difference. Levamisole hydrochloride was ineffective on third-stage larvae of L. minor. These findings explain the massive expulsion of live adult worms, as well as the use of long treatment schemes, owing to the persistence of larvae and eggs in human parasitic lesions.

  13. EVALUATION OF THE THERAPEUTIC EFFICACY OF LEVAMISOLE HYDROCHLORIDE ON THIRD-STAGE LARVAE OF Lagochilascaris minor IN EXPERIMENTALLY INFECTED MICE.

    Science.gov (United States)

    Campos, Dulcinéa Maria Barbosa; Barbosa, Alverne Passos; Oliveira, Jayrson Araújo; Barbosa, Carlos Augusto Lopes; Lobo, Tamara Flavia Correa; Silva, Luana Gabriella; Thomaz, Douglas Vieira; Peixoto, Josana de Castro

    2016-01-01

    Lagochilascariosis, a disease caused by Lagochilascaris minor, affects the neck, sinuses, tonsils, lungs, the sacral region, dental alveoli, eyeballs and the central nervous system of humans. A cycle of autoinfection may occur in human host tissues characterized by the presence of eggs, larvae and adult worms. This peculiarity of the cycle hinders therapy, since there are no drugs that exhibit ovicidal, larvicidal and vermicidal activity. Given these facts, we studied the action of levamisole hydrochloride on third-stage larvae in the migration phase (G1) and on encysted larvae (G3) of L. minor. To this end, 87 inbred mice of the C57BL/6 strain were divided into test groups comprising 67 animals (G1-37; G3-30) and a control group (G2-10; G4-10) with 20 animals. Each animal was inoculated orally with 2,000 infective eggs of the parasite. The animals of the test groups were treated individually with a single oral dose of levamisole hydrochloride at a concentration of 0.075 mg. The drug was administered either 30 minutes prior to the parasite inoculation (G1 animals) or 120 days after the inoculation (G3 animals). The mice in the control groups were not treated with the drug. After the time required for the migration and the encysting of L. minor larvae, all the animals were euthanized and their tissues examined. The data were analyzed using the Student's unpaired t-test and the Levene test. The groups showed no statistically significant difference. Levamisole hydrochloride was ineffective on third-stage larvae of L. minor. These findings explain the massive expulsion of live adult worms, as well as the use of long treatment schemes, owing to the persistence of larvae and eggs in human parasitic lesions.

  14. EVALUATION OF THE THERAPEUTIC EFFICACY OF LEVAMISOLE HYDROCHLORIDE ON THIRD-STAGE LARVAE OF Lagochilascaris minor IN EXPERIMENTALLY INFECTED MICE

    Science.gov (United States)

    CAMPOS, Dulcinéa Maria Barbosa; BARBOSA, Alverne Passos; OLIVEIRA, Jayrson Araújo; BARBOSA, Carlos Augusto Lopes; LOBO, Tamara Flavia Correa; SILVA, Luana Gabriella; THOMAZ, Douglas Vieira; PEIXOTO, Josana de Castro

    2016-01-01

    Lagochilascariosis, a disease caused by Lagochilascaris minor, affects the neck, sinuses, tonsils, lungs, the sacral region, dental alveoli, eyeballs and the central nervous system of humans. A cycle of autoinfection may occur in human host tissues characterized by the presence of eggs, larvae and adult worms. This peculiarity of the cycle hinders therapy, since there are no drugs that exhibit ovicidal, larvicidal and vermicidal activity. Given these facts, we studied the action of levamisole hydrochloride on third-stage larvae in the migration phase (G1) and on encysted larvae (G3) of L. minor. To this end, 87 inbred mice of the C57BL/6 strain were divided into test groups comprising 67 animals (G1-37; G3-30) and a control group (G2-10; G4-10) with 20 animals. Each animal was inoculated orally with 2,000 infective eggs of the parasite. The animals of the test groups were treated individually with a single oral dose of levamisole hydrochloride at a concentration of 0.075 mg. The drug was administered either 30 minutes prior to the parasite inoculation (G1 animals) or 120 days after the inoculation (G3 animals). The mice in the control groups were not treated with the drug. After the time required for the migration and the encysting of L. minor larvae, all the animals were euthanized and their tissues examined. The data were analyzed using the Student's unpaired t-test and the Levene test. The groups showed no statistically significant difference. Levamisole hydrochloride was ineffective on third-stage larvae of L. minor. These findings explain the massive expulsion of live adult worms, as well as the use of long treatment schemes, owing to the persistence of larvae and eggs in human parasitic lesions. PMID:27253745

  15. Clinical Effects for Patients with Recurrent Advanced Non-small Cell Lung Cancer Treated with Icotinib Hydrochloride

    Directory of Open Access Journals (Sweden)

    Jingying NONG

    2013-05-01

    Full Text Available Background and objective Icotinib hydrochloride is the third single target EGFR-TKI used in clinical treatment of advanced non-small cell lung cancer (NSCLC. Clinical research reports on its efficacy and survival in patients with Recurrent Advanced NSCLC are still little.The aim of this study is to evaluate the efficacy and survival of Icotinib hydrochloride for patients with advanced non-small cell lung cancer who failed to previous chemotherapy and explore the association of clinical features with the efficacy and survival. Methods The clinical data of 60 NSCLC patients referred to the Beijing Chest Hospital, Capital Medical University from March 2009 to July 2012 were retrospectively analyzed. Results The overall response rate (ORR was 45.0% and the disease control rate (DCR was 80.0%. The median progression-free survival (PFS time was 6.7 months. RR and PFS in female were superior to male (P=0.014, 0.013, respectively. RR, DCR in 2nd-line subgroup were superior to ≥3rd-line subgroup (P=0.020, 0.024, respectively. RR, DCR and PFS in EGFR mutation carriers were significantly superior to wild-type patients (P=0.006, <0.001, 0.002, respectively . There was no statistical difference in RR and PFS between those age <65 and ≥65 or PS<2 and PS≥2. There was no statistical difference in RR and DCR between exon 19 deletion and exon 21 mutations, while the former had much longer PFS (P=0.020. EGFR mutation and exon 19 deletion are the independent prognostic factors to significantly improve the PFS (P=0.009, 0.012, respectively. The side effects were generally mild and consisted of rash and diarrhea. Conclusion Icotinib hydrochloride is effective especially in EGFR mutation carriers and well tolerated in patients with recurrent advanced non-small-cell lung cancer.

  16. 长效支气管扩张剂盐酸奥达特罗%Olodaterol hydrochloride, a long-acting bronchodilator

    Institute of Scientific and Technical Information of China (English)

    沈继敏; 郝济敏; 时国朝

    2013-01-01

    Olodaterol hydrochloride is a novel, selective, long-acting β2-adrenoceptor agonist. It has a rapid onset of action and 24-hour bronchodilator efficacy with minimal systemic pharmacodynamic effects. Since allowing once-daily administration, olodaterol hydrochloride shows an improved effect in patient compliance and provides a new choice for the treatment of obstructive pulmonary diseases. This review introduces the pharmacological action, clinical studies, adverse reaction and the combination treatments with other drugs of olodaterol hydrochloride.%  盐酸奥达特罗是一种新型选择性速效、长效β2-肾上腺能受体激动剂,可迅速起效且维持24 h的支气管扩张作用,全身性副作用很少。由于只需每天用药1次,故能提高患者的依从性,给以气道阻塞为特征的疾病治疗提供一种新的治疗选择。本文介绍盐酸奥达特罗的药理作用、临床研究、不良反应和与其他药物联合治疗的研究情况。

  17. Preparation and Characterization of Chitosan Hydrochloride

    Institute of Scientific and Technical Information of China (English)

    FENG; HuiXia

    2001-01-01

    Chitin 1 is a biodegradable and nontoxic polysaccharide widely spread among marine and terrestrial invertebrates and fungi. It is usually obtained from waste materials of the sea food-processing industry, mainly shells of crab, shrimp, prawn and krill. Native chitin occurs in such natural composite materials usually combined with inorganics, proteins, lipids and pigments. Its isolation calls for chemical treatments to eliminate these contaminants, some of which maybe coimmercially explored. By treating crude chitin with aqueous 40~50% sodium hydroxide at 110~115℃ chitosan is obtained. However, the fully deacetylated product is rarely obtained due to the risks of side reactions and chain deplolymerization. Chitosan and chitin are closely related since both are linear polysaccharides containing 2-acetamido-2-deoxy-D-glucopyranose and 2-amino-2-deoxy-D-glucopyranose units joined by β (1→4) glycosidic bonds. They can be distinguished by their contents of the above-mentioned units and by their solubilities in aqueous media. The acetylated units predominate in chitin while chitosan chains contain mostly deacetylated units. Chitin is soluble in a very limited number of solvents while chitosan is soluble in aqueous dilute solutions of a number of mineral and organic acids, being the most common ones, the hydrochloric and acetic acids. In aqueous dilute acid media chitosan forms salts, producing polyelectrolyte chains bearing positive charges on the nitrogen atoms of their amine groups. In fact the salt of chitosan may be formed in a separate step or as a consequence of the presence of acid in the water suspension of the neutralized form of chitosan.  ……

  18. Preparation and Characterization of Chitosan Hydrochloride

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ Chitin 1 is a biodegradable and nontoxic polysaccharide widely spread among marine and terrestrial invertebrates and fungi. It is usually obtained from waste materials of the sea food-processing industry, mainly shells of crab, shrimp, prawn and krill. Native chitin occurs in such natural composite materials usually combined with inorganics, proteins, lipids and pigments. Its isolation calls for chemical treatments to eliminate these contaminants, some of which maybe coimmercially explored. By treating crude chitin with aqueous 40~50% sodium hydroxide at 110~115℃ chitosan is obtained. However, the fully deacetylated product is rarely obtained due to the risks of side reactions and chain deplolymerization. Chitosan and chitin are closely related since both are linear polysaccharides containing 2-acetamido-2-deoxy-D-glucopyranose and 2-amino-2-deoxy-D-glucopyranose units joined by β (1→4) glycosidic bonds. They can be distinguished by their contents of the above-mentioned units and by their solubilities in aqueous media. The acetylated units predominate in chitin while chitosan chains contain mostly deacetylated units. Chitin is soluble in a very limited number of solvents while chitosan is soluble in aqueous dilute solutions of a number of mineral and organic acids, being the most common ones, the hydrochloric and acetic acids. In aqueous dilute acid media chitosan forms salts, producing polyelectrolyte chains bearing positive charges on the nitrogen atoms of their amine groups. In fact the salt of chitosan may be formed in a separate step or as a consequence of the presence of acid in the water suspension of the neutralized form of chitosan.

  19. [Examination of effectiveness of olopatadine hydrochloride in atopic dermatitis].

    Science.gov (United States)

    Shimizu, Tadamichi; Mashiko, Maki; Shimizu, Hiroshi

    2005-02-01

    Subjective/objective symptoms (itching, papula, erythema, lichenification, desquamation, scratching, erosion) and the levels of IgE, LDH, interleukin (IL) -6, thymus and activation-regulated chemokine (TARC) were compared before and after administering olopatadine hydrochloride (ALLELOCK tablets) to 17 atopic dermatitis (AD) patients. Subject/objective symptoms improved significantly after administering the agent, and the total dosage of the combined topical steroids was also significantly decreased after administration (p<0.05), although IgE, IL-6 and LDH levels did not change, TARC was significantly decreased (p<0.05). The correlation between the levels of IgE, IL-6, LDH and TARC before and after the administration was examined. There was a positive correlation between IgE and TARC (r=0.62, p<0.01) and between IL-6 and TARC (r=0.78, p<0.01). Olopatadine hydrochloride is therefore useful in improving the symptoms in AD, and TARC may be used as an indicator of the symptom improvement.

  20. Growth of glycine ethyl ester hydrochloride and its characterizations

    Science.gov (United States)

    Venkatesan, G.; Pari, S.

    2016-11-01

    Single crystal of glycine ethyl ester hydrochloride by slow evaporation method is reported. The grown crystal characterized by single crystal X-ray diffraction, FT-IR, UV-Vis-NIR and fluorescence spectroscopy. It is established that the crystal falls under the monoclinic system and space group P21/c with the cell parameters as: a=8.565 Å, b=12.943 Å, c=6.272 Å, α=γ=90°, β=103.630º. UV-Vis-NIR spectrum shows indirect allowed transition with a band gap of 5.21 eV and other optical properties are measured. The crystal is also shown to have a high transmittance in the visible region. The third order nonlinear property and optical limiting have been investigated using Z-Scan technique. Complex impedance spectrum measured at the dc conductivity. Dependence of dielectric constant, dielectric loss and ac conductivity on frequency at different temperature of applied ac field is analyzed. The mechanical behavior has been assessed by Vickers microhardness indenter. The thermal behavior of glycine ethyl ester hydrochloride was analyzed using TG/DTA thermal curves. From the thermal study, the material was found to possess thermal stability up to 174 °C. The predicted NLO properties, UV-Vis transmittance and Z-scan studies indicate that is an attractive material for photonics optical limiting applications.

  1. SPECTROPHOTOMETRIC, ATOMIC ABSORPTION AND CONDUCTOMETRIC ANALYSIS OF TRAMADOL HYDROCHLORIDE

    Directory of Open Access Journals (Sweden)

    Sara M. Anis

    2011-09-01

    Full Text Available Six simple and sensitive spectroscopic and conductometric procedures (A-F were developed for the determination of tramadol hydrochloride. Methods A, B and C are based on the reaction of cobalt (II thiocyanate with tramadol to form a stable ternary complex, which could be measured by spectrophotometric (method A, atomic absorption (method B or conductometric (method C procedures. Methods D and E depend on the reaction of molybdenum thiocyanate with tramadol to form a stable ternary complex, measured by spectrophotometric means (method D or by atomic absorption procedures (method E, while method F depends on the formation of an ion pair complex between the studied drug and bromothymol blue which is extractable into methylene chloride. Tramadol hydrochloride could be assayed in the range of 80-560 and 40-–220 μg ml-1, 1-15 mg ml-1 and 2.5-22.5, 1.25-11.25 and 5-22 μg ml-1 using methods A,B,C,D,E and F, respectively. Various experimental conditions were studied. The results obtained showed good recoveries. The proposed procedures were applied successfully to the analysis of tramadol in its pharmaceutical preparations and the results were favorably comparable with the official method.

  2. FORMULATION AND DISSOLUTION STUDY OF DILTIAZEM HYDROCHLORIDE IMMEDIATE RELEASE TABLETS

    Directory of Open Access Journals (Sweden)

    BRAHMAIAH BONTHAGARALA

    2014-08-01

    Full Text Available Objective: The main aim and objective of the work is to formulate immediate release tablets using different direct compression vehicles (DCV’S in different ratios. Methods: In the present study, design of oral immediate release tablets of Diltiazem hydrochloride by direct compression technique was carried out. Results: The main motive is to compare the dissolution profile of these formulations and conclude the best formulation which release drug at a faster rate . To determine the best fit dissolution profile for the dosage forms. Diltiazem hydrochloride tablets were formulated by using microcrystalline cellulose (diluent, potato starch, acacia (binder and magnesium stearate (lubricant. The granules were compressed into tablets and were subjected to dissolution studies. The dissolution profile of the formulation F2 was found to have better dissolution rate compared to others. Conclusion: The Invitro dissolution studies of all the formulations were conducted and the results were obtained, it was concluded that formulation F2 was the best with fast release of drug compared to others.

  3. Modulation of venlafaxine hydrochloride release from press coated matrix tablet

    Directory of Open Access Journals (Sweden)

    Gohel M

    2008-01-01

    Full Text Available The aim of present study was to prepare novel modified release press coated tablets of venlafaxine hydrochloride. Hydroxypropylmethylcellulose K4M and hydroxypropylmethylcellulose K100M were used as release modifier in core and coat, respectively. A 3 2 full factorial design was adopted in the optimization study. The drug to polymer ratio in core and coat were chosen as independent variables. The drug release in the first hour and drug release rate between 1 and 12 h were chosen as dependent variables. The tablets were characterized for dimension analysis, crushing strength, friability and in vitro drug release. A check point batch, containing 1:2.6 and 1:5.4 drug to polymer in core and coat respectively, was prepared. The tablets of check point batch were subjected to in vitro drug release in dissolution media with pH 5, 7.2 and distilled water. The kinetics of drug release was best explained by Korsmeyer and Peppas model (anomalous non-Fickian diffusion. The systematic formulation approach enabled us to develop modified release venlafaxine hydrochloride tablets.

  4. TRIMETAZIDINE HYDROCHLORIDE TRANSDERMAL PATCH: FORMULATION AND IN-VITRO EVALUATION

    Directory of Open Access Journals (Sweden)

    Sarfaraz Md

    2012-07-01

    Full Text Available The present study was carried out to formulate and evaluate matrix-type transdermal formulations containing trimetazidine hydrochloride with polymers such as carboxymethyl chitosan and hydroxypropylmethylcellulose (HPMC 5cps by solvent evaporation technique with glycerin, as plasticizer. The prepared patches were tested for their physicochemical characteristics such as thickness, weight variation, drug content uniformity, folding endurance and tensile strength. The partition coefficient study was performed using n-octanol as the organic phase and phosphate buffer pH 7.4 as an aqueous phase and it was found to be 1.01. In-vitro release studies of trimetazidine hydrochloride-loaded patches in phosphate buffer (pH, 7.4 exhibited drug release in the range of 89.40 to 92.10 % in 24 hrs. The parameter flux (J was calculated and it was in the range of 1.325 to 2.898 mg/cm2/hr. Based on optimization studies, patches containing carboxymethyl chitosan patches were chosen as optimized formulation. Skin irritation studies were performed on optimized transdermal patch and were found to be free of irritation. The patches were subjected to short term stability studies and were found stable. FTIR studies revealed no interactions between drug and excipients. Data of in vitro release from optimized patches were fit in to different equations and kinetic models such as zero order, first-order, Higuchi and Korsmeyer-Peppas models to explain release kinetics.

  5. 维拉佐酮盐酸盐%vilazodone hydrochloride

    Institute of Scientific and Technical Information of China (English)

    李赛

    2011-01-01

    由Trovis Pharma LLC制药公司研制的维拉佐酮盐酸盐(vilazodone hydrochloride)于2011年1月21日由FDA批准上市,商品名为Viibryd,用于治疗成年人重度抑郁症(major depressive disorder,MDD)[1].Viibryd将以10 mg、20 mg和40 mg片剂上市.Viibryd中文化学名称:5-[4-[4-(5-氰基-1H-吲哚-3-基)丁基]-1-哌嗪基]-2-苯并呋喃草酰胺盐酸盐;英文化学名称:5-[4-[4-(5-cyano-1 H-indol-3-yl)butyl]-1 -piperaz-inyl]-2-benzofurancarboxamide hydrochloride;分子式:C26-H27N5O2 ·HCl;分子量:477.99;CAS登记号:163521-08-2.

  6. Structural characterisation and dehydration behaviour of siramesine hydrochloride.

    Science.gov (United States)

    Zimmermann, Anne; Tian, Fang; de Diego, Heidi Lopez; Frydenvang, Karla; Rantanen, Jukka; Elema, Michiel Ringkjøbing; Hovgaard, Lars

    2009-10-01

    In this study the crystal structures of siramesine hydrochloride anhydrate alpha-form and siramesine hydrochloride monohydrate were determined, and this structural information was used to explain the physicochemical properties of the two solid forms. In the crystal structure of the monohydrate, each water molecule is hydrogen bonded to two chloride ions, and thus the water is relatively strongly bound in the crystal. No apparent channels for dehydration were observed in the monohydrate structure, which could allow transmission of structural information during dehydration. Instead destructive dehydration occurred, where the elimination of water from the monohydrate resulted in the formation of an oily phase, which subsequently recrystallised into one or more crystalline forms. Solubility and intrinsic dissolution rate of the anhydrate alpha-form and the monohydrate in aqueous media were investigated and both were found to be lower for the monohydrate compared to the anhydrate alpha-form. Finally, the interactions between water molecules and chloride ions in the monohydrate as well as changes in packing induced by water incorporation could be detected by spectroscopic techniques.

  7. OPTIMIZATION OF CONCENTRATION OF POLYHEXANIDE HYDROCHLORIDE IN MULTIPURPOSE SOLUTION.

    Directory of Open Access Journals (Sweden)

    A. Arora

    2010-01-01

    Full Text Available There are a number of foreign pathogenic microorganisms like viruses, bacteria, yeast, fungi and protozoa which can inadvertently be introduced into eye via contact lens and hence disinfection is a vital part. Multifunctional solutions are generally intended to combine the action of cleaning disinfecting, rinsing lubricating deproteinising and soaking in one single product.In order to optimization of concentration of Polyhexanide hydrochloride in multipurpose solution some microbiological studies were performed by taking five microorganisms which are more prevalent in the infected eye condition. The nutrient agar and sabourad's agar media were used for bacteria and yeast mould respectively. The media were prepared as per I.P and sterilised by autoclaving and poured into Petri plates. The media when cooled to 42°C, 0.5 ml of the culture was added.The optimum concentration of Polyhexanide hydrochloride is 0.0002% which is an effective concentration against five microorganisms that are most prevalent in the infected eye condition.It was concluded that the multipurpose solution containing 2.0 g/ml of polyhexanide were found to be better in terms of antimicrobial activity

  8. Modulation of venlafaxine hydrochloride release from press coated matrix tablet.

    Science.gov (United States)

    Gohel, M C; Soni, C D; Nagori, S A; Sarvaiya, K G

    2008-01-01

    The aim of present study was to prepare novel modified release press coated tablets of venlafaxine hydrochloride. Hydroxypropylmethylcellulose K4M and hydroxypropylmethylcellulose K100M were used as release modifier in core and coat, respectively. A 3(2) full factorial design was adopted in the optimization study. The drug to polymer ratio in core and coat were chosen as independent variables. The drug release in the first hour and drug release rate between 1 and 12 h were chosen as dependent variables. The tablets were characterized for dimension analysis, crushing strength, friability and in vitro drug release. A check point batch, containing 1:2.6 and 1:5.4 drug to polymer in core and coat respectively, was prepared. The tablets of check point batch were subjected to in vitro drug release in dissolution media with pH 5, 7.2 and distilled water. The kinetics of drug release was best explained by Korsmeyer and Peppas model (anomalous non-Fickian diffusion). The systematic formulation approach enabled us to develop modified release venlafaxine hydrochloride tablets.

  9. Formulation and evaluation of transdermal patches of papaverine hydrochloride

    Directory of Open Access Journals (Sweden)

    Shah Samip

    2010-01-01

    Full Text Available Transdermal patches of papaverine hydrochloride were prepared by the solvent casting method using ethyl cellulose: PVP, PVA: PVP and Eudragit RL-100: Eudragit RS-100 using different ratios. The physicochemical parameters such as flexibility, thickness, smoothness, weight variation, moisture content, hardness and tensile strength were evaluated for the prepared patches. The formulation exhibited flexibility, uniform thickness and weight, smoothness, good drug content (92 to 96%, and little moisture content. The in vitro diffusion studies were carried out using modified Keshery-Chein cell using cellophane as the diffusion membrane and the formulation followed the Higuchi diffusion mechanism. The formulation containing PVA: PVP as polymers showed faster release rate (hydrophilic polymers compared to Eudragit RL-100: Eudragit RS-100 (hydrophobic polymers or combination of hydrophilic and hydrophobic polymers (ethyl cellulose and PVP. The stability studies indicated that all the patches maintained good physicochemical properties and drug content after storing the patches in different storage conditions. Compatibility studies indicated that there was no interaction between the drug and polymers. In vivo studies showed that papaverine hydrochloride helps in decreasing the effect of isoproterenol-induced myocardial necrosis. Hence, the aim of the present study was to prepare the sustained release formulation (Transdermal patches of the drug using different blend of polymers. The formulated patches containing the hydroplilic polymers showed best release rate of drug.

  10. [Clinical evaluation of roxatidine acetate hydrochlorides as a preanesthetic medication].

    Science.gov (United States)

    Namba, M; Chihara, E; Ibuki, T; Ashida, H; Fukushima, H; Tanaka, Y

    2001-02-01

    Roxatidine acetate hydrochloride capsule is slowly absorbed from the gastrointestinal tract, and its acid suppressive effect on the stomach is long-lasting compared with other H2-blockers. The reduction of gastric juice in perioperative period is considered advantageous for patients not only because it decreases the risk for aspiration pneumonia but also because it reduces the risk of bronchial spasm induced by gastroesophageal reflux of acidic gastric content. The effects of single oral administration of roxatidine acetate hydrochloride 150 mg at night before the operation on the volume and pH of gastric juice were investigated during anesthesia using two types of anesthetic agents (isoflurane and propofol) in 93 patients of three age groups (group Y: age 20-40, group M: age 41-64, group O: age 65 roxatidine on reduction of gastric juice was found at the time of anesthetic induction and 2 hours after the induction in any age group with either anesthetic agent. The serum concentration of roxatidine at the time of induction was much higher in group O. The value of residual concentration of roxatidine 20 hours after oral intake was estimated from the intraoperative measurements of serum concentration. The results suggest that single administration at night before the operation is sufficient for the oldest group, but an additive dose is recommended for the younger groups.

  11. Formulation and evaluation of tramadol hydrochloride rectal suppositories

    Directory of Open Access Journals (Sweden)

    Saleem M

    2008-01-01

    Full Text Available Rectal suppositories of tramadol hydrochloride were prepared using different bases and polymers like PEG, cocoa butter, agar and the effect of different additives on in vitro release of tramadol hydrochloride was studied. The agar-based suppositories were non-disintegrating/non-dissolving, whereas PEGs were disintegrating/dissolving and cocoa butter were melting suppositories. All the prepared suppositories were evaluated for various physical parameters like weight variation, drug content and hardness. The PEG and cocoa butter suppositories were evaluated for macromelting range, disintegration and liquefaction time. In vitro release study was performed by USP type I apparatus. The prepared suppositories were within the permissible range of all physical parameters. In vitro drug release was in the order of PEG>Agar>cocoa butter. Addition of PVP, HPMC in agar suppositories retards the release. The mechanism of drug release was diffusion controlled and follows first order kinetics. The results suggested that blends of PEG of low molecular weight (1000 with high molecular weight (4000 and 6000 in different percentage and agar in 10% w/w as base used to formulate rapid release suppositories. The sustained release suppositories can be prepared by addition of PVP, HPMC in agar-based suppositories and by use of cocoa butter as base.

  12. A novel and rapid microbiological assay for ciprofloxacin hydrochloride

    Institute of Scientific and Technical Information of China (English)

    Edith Cristina Laignier Cazedey; Hérida Regina Nunes Salgado

    2013-01-01

    The present work reports a simple, fast and sensitive microbiological assay applying the turbidimetric method for the determination of ciprofloxacin hydrochloride (CIPRO HCl) in ophthalmic solutions. The validation method yielded good results and included excellent linearity, precision, accuracy and specificity. The bioassay is based on the inhibitory effect of CIPRO HCl upon the strain of Staphylococcus epidermidis ATCC 12228 used as the test microorganism. The results were treated statistically by analysis of variance (ANOVA) and were found to be linear (r¼0.9994, in the range of 14.0-56.0 mg/mL), precise (intraday RSD%¼2.06;interday RSD%¼2.30) and accurate (recovery ¼ 99.7%). The turbidimetric assay was compared to the UV spectrophotometric and HPLC methods for the same drug. The turbidimetric bioassay described on this paper for determination of ciprofloxacin hydrochloride in ophthalmic solution is an alternative to the physicochemical methods disclosed in the literature and can be used in quality control routine.

  13. Growth of glycine ethyl ester hydrochloride and its characterizations

    Energy Technology Data Exchange (ETDEWEB)

    Venkatesan, G.; Pari, S., E-mail: sparimyur@gmail.com

    2016-11-15

    Single crystal of glycine ethyl ester hydrochloride by slow evaporation method is reported. The grown crystal characterized by single crystal X-ray diffraction, FT-IR, UV–Vis–NIR and fluorescence spectroscopy. It is established that the crystal falls under the monoclinic system and space group P21/c with the cell parameters as: a=8.565 Å, b=12.943 Å, c=6.272 Å, α=γ=90°, β=103.630º. UV–Vis–NIR spectrum shows indirect allowed transition with a band gap of 5.21 eV and other optical properties are measured. The crystal is also shown to have a high transmittance in the visible region. The third order nonlinear property and optical limiting have been investigated using Z-Scan technique. Complex impedance spectrum measured at the dc conductivity. Dependence of dielectric constant, dielectric loss and ac conductivity on frequency at different temperature of applied ac field is analyzed. The mechanical behavior has been assessed by Vickers microhardness indenter. The thermal behavior of glycine ethyl ester hydrochloride was analyzed using TG/DTA thermal curves. From the thermal study, the material was found to possess thermal stability up to 174 °C. The predicted NLO properties, UV–Vis transmittance and Z-scan studies indicate that is an attractive material for photonics optical limiting applications.

  14. Structural characterization of anhydrous naloxone- and naltrexone hydrochloride by high resolution laboratory X-ray powder diffraction and thermal analysis.

    Science.gov (United States)

    Sugimoto, Kunihisa; Dinnebier, Robert E; Zakrzewski, Marek

    2007-12-01

    The crystal structures of the analgesic compounds anhydrous naloxone and naltrexone hydrochloride were determined ab initio from high resolution laboratory X-ray powder diffraction data. Both compounds crystallize in the orthorhombic space group P2(1)2(1)2(1) with lattice parameters of a = 14.6588(10) A, b = 17.4363(9) A, c = 7.96200(22) A, and V = 2035.06(23) A(3) for naloxone hydrochloride and a = 15.4560(5) A, b = 14.9809(4) A, c = 7.84121(18) A, and V = 1815.58(11) A(3) for naltrexone hydrochloride. The crystal structure of anhydrous naloxone hydrochloride forms one-dimensional chains through hydrogen bonds. In the crystal structure of anhydrous naltrexone hydrochloride, two-dimensional sheets are formed by hydrogen bonds. The dehydration processes of naloxone hydrochloride dehydrate and naltrexone hydrochloride tetrahydrate was analyzed by DTA, DSC, TG, and MG.

  15. Efficacy of benzydamine hydrochloride dripping at endotracheal tube cuff for prevention of postoperative sore throat.

    Science.gov (United States)

    Nimmaanrat, Sasikaan; Chokkijchai, Kedsirin; Chanchayanon, Thavat

    2013-10-01

    Postoperative sore throat (POST) is a frequent consequence following ETT intubation, which may negatively affect the postoperative course and patient satisfaction. Benzydamine hydrochloride is a topically-applied non-steroidal anti-inflammatory drug (NSAID). The authors evaluated the analgesic effect of benzydamine hydrochloride dripping on the ETT cuff on POST. Eighty-six patients participated in this randomized controlled trial. They were assigned into either the benzydamine hydrochloride or the control group. The whole ETT cuff was dripped either with 3 ml (4.5 mg) of benzydamine hydrochloride or nothing five minutes prior to anesthesia induction. The incidence and severity of POST at 0, 2, 4, 6, 12 and 24 hours postoperatively were assessed. The potential adverse effects of benzydamine hydrochloride (throat numbness throat burning sensation, dry mouth, and thirst) were also evaluated. Twenty-five patients (58.14%) in each group had POST (p-value = 1). The severity of POST (calculated from affected patients) in both groups at different time points was not significantly different. Patients in the benzydamine hydrochloride group did not have a higher incidence of adverse effects. We found that dripping benzydamine hydrochloride on the ETT cuff neither reduced the incidence of POST nor increased the incidence of adverse effects in comparison with no intervention.

  16. Radiation effects on the fluoxetine hydrochloride toxicity in the presence of domestic sewage

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Vanessa H. Ogihara; Borrely, Sueli I., E-mail: vanessa.ogihara@usp.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Campos, Fabio; Piveli, Roque P. [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Escola Politecnica. Centro Tecnologico de Hidraulica

    2013-07-01

    The sanitation field is directly related to environmental quality and health. The improvements in wastewater treatment systems provide benefits to the environment and their population. It is clearly understood that the conventional wastewater treatment does not remove many micropollutants, including some medicinal products, and that these products can be toxic to living organisms. The goal of this research was the assessment of toxicity of fluoxetine hydrochloride (FH) as well as the irradiation application to remove FH from waters. The FH was irradiated in water solutions and also contained in domestic sewage. Both types of samples were irradiated at a Dynamitron® Electron Beam Accelerator (EBA). The Vibrio fischeri bacteria was applied as biological assay to the samples (water solution of FH; untreated sewage and the mixture of untreated sewage + FH). The efficiency was 1.44% to 26.21% less toxic after treatments. UV-Vis Spectrometry showed the degradation of FH by radiation. 2.5 kGy was a suitable dose that could be suggested for environmental application of Electron Beam Technology. (author)

  17. Lanthanum carbonate versus sevelamer hydrochloride: improvement of metabolic acidosis and hyperkalemia in hemodialysis patients.

    Science.gov (United States)

    Filiopoulos, Vassilis; Koutis, Ioannis; Trompouki, Sofia; Hadjiyannakos, Dimitrios; Lazarou, Dimitrios; Vlassopoulos, Dimosthenis

    2011-02-01

    Sevelamer hydrochloride (SH) has been reported to aggravate metabolic acidosis and hyperkalemia. This study was performed to evaluate acid-base status and serum potassium changes after replacing SH with lanthanum carbonate (LC) in hemodialysis patients. SH was prescribed for 24 weeks in 14 stable hemodialysis patients and replaced by LC in a similar treatment schedule. Laboratory tests, including indices of acid-base status, nutrition, bone/mineral metabolism, and dialysis adequacy, were performed monthly during the study. Dialysate bicarbonate, potassium and calcium concentrations remained constant. Serum bicarbonate and pH rose, and serum potassium dropped significantly under LC. Alkaline phosphatase also decreased significantly under LC. No significant differences were observed in the other studied parameters between the two treatment periods. Control of serum phosphate was similar under both phosphate-binders and no differences were observed in calcium, Ca × P product, CRP, or lipid levels. Dialysis adequacy was constantly kept within K/DOQI target-range. Although full compliance to treatment was reported, three patients on LC complained of gastrointestinal upset and/or a metallic taste, and four had difficulty chewing the LC tablet. LC improves metabolic acidosis and hyperkalemia in hemodialysis patients previously under SH. Although both medications are well-tolerated, the gastrointestinal side-effects appear to occur more frequently with LC; a fact that, together with difficulties in chewing the tablet, may result in decreased compliance.

  18. Developmental rates of immatures of three Chrysomya species (Diptera: Calliphoridae) under the effect of methylphenidate hydrochloride, phenobarbital, and methylphenidate hydrochloride associated with phenobarbital.

    Science.gov (United States)

    Rezende, Fábio; Alonso, Marcela A; Souza, Carina M; Thyssen, Patrícia J; Linhares, Arício X

    2014-05-01

    Entomotoxicology is focused on obtaining data on necrophagous entomofauna, for criminal investigations purposes. This study aimed to evaluate the effect of different concentrations of methylphenidate hydrochloride, phenobarbital, and their association on the developmental rate, larval and pupal survivorship, and the interval of emergence of adults of Chrysomya albiceps (Wiedemann), Chrysomya megacephala (Fabricius), and Chrysomya putoria (Wiedemann) (Diptera: Calliphoridae). Considering the therapeutic dose (TD) of methylphenidate hydrochloride (0.29 mg/Kg), the concentrations tested were 10× TD, 50× TD, and 100× TD. For phenobarbital, the concentrations used were 1× TD (=150 mg/Kg), 3.3× TD, and 6.7× TD. For the association of the drugs, the combinations used were 10× TD-methylphenidate hydrochloride plus 1× TD-phenobarbital, 50× TD-methylphenidate hydrochloride plus 3.3× TD-phenobarbital, and 100× TD-methylphenidate hydrochloride plus 6.7× TD-phenobarbital. The control group, without addition of drug, was maintained under the same conditions of temperature (25 ± 1 °C), humidity (70 ± 10%), and photoperiod (12 h). Specimens of each group were weighed every 12 h until pupariation. The developmental rate of the three Chrysomya species immatures was monitored. For C. albiceps the developmental time was delayed in 24 h for methylphenidate hydrochloride group and in 12 h for the phenobarbital and the drugs association groups. The effect was observed only at specific ages for C. megacephala, without altering the developmental time. For C. putoria, the developmental time was delayed in 12 h for methylphenidate hydrochloride group and in 24 h for the phenobarbital and the drugs association groups. The emergence interval was similar among all experimental groups, but larval and pupal viabilities were affected in different ways.

  19. Extractive determination of ephedrine hydrochloride and bromhexine hydrochloride in pure solutions, pharmaceutical dosage form and urine samples.

    Science.gov (United States)

    Abdel-Ghani, N T; Rizk, M S; Mostafa, M

    2013-07-01

    Simple, rapid, sensitive, precise and accurate spectrophotometeric methods for the determination of ephedrine hydrochloride (E-HCl) and bromhexine hydrochloride (Br-HCl) in bulk samples, dosage form and in spiked urine samples were investigated. The methods are based on the formation of a yellow colored ion-associates due to the interaction between the examined drugs with picric acid (PA), chlorophyllin coppered trisodium salt (CLPH), alizarin red (AR) and ammonium reineckate (Rk) reagents. A buffer solution had been used and the extraction was carried out using organic solvent, the ion associates exhibit absorption maxima at 410, 410, 430 and 530 nm of (Br-HCl)with PA, CLPH, AR and Rk respectively; 410, 410, 435 and 530 of (E-HCl) with PA, CLPH, AR and Rk respectively. (E-HCl) and (Br-HCl) could be determined up to 13, 121, 120 and 160; 25, 200, 92 and 206 μg mL(-1), using PA, CLPH, AR and Rk respectively. The optimum reaction conditions for quantitative analysis were investigated. In addition, the molar absorptivity, Sandell sensitivity were determined for the investigated drug. The correlation coefficient was ≥0.995 (n=6) with a relative standard deviation (RSD) ≤1.15 for five selected concentrations of the reagents. Therefore the concentration of Br-HCl and E-HCl drugs in their pharmaceutical formulations and spiked urine samples had been determined successfully.

  20. Extractive determination of ephedrine hydrochloride and bromhexine hydrochloride in pure solutions, pharmaceutical dosage form and urine samples

    Science.gov (United States)

    Abdel-Ghani, N. T.; Rizk, M. S.; Mostafa, M.

    2013-07-01

    Simple, rapid, sensitive, precise and accurate spectrophotometeric methods for the determination of ephedrine hydrochloride (E-HCl) and bromhexine hydrochloride (Br-HCl) in bulk samples, dosage form and in spiked urine samples were investigated. The methods are based on the formation of a yellow colored ion-associates due to the interaction between the examined drugs with picric acid (PA), chlorophyllin coppered trisodium salt (CLPH), alizarin red (AR) and ammonium reineckate (Rk) reagents. A buffer solution had been used and the extraction was carried out using organic solvent, the ion associates exhibit absorption maxima at 410, 410, 430 and 530 nm of (Br-HCl)with PA, CLPH, AR and Rk respectively; 410, 410, 435 and 530 of (E-HCl) with PA, CLPH, AR and Rk respectively. (E-HCl) and (Br-HCl) could be determined up to 13, 121, 120 and 160; 25, 200, 92 and 206 μg mL-1, using PA, CLPH, AR and Rk respectively. The optimum reaction conditions for quantitative analysis were investigated. In addition, the molar absorptivity, Sandell sensitivity were determined for the investigated drug. The correlation coefficient was ⩾0.995 (n = 6) with a relative standard deviation (RSD) ⩽1.15 for five selected concentrations of the reagents. Therefore the concentration of Br-HCl and E-HCl drugs in their pharmaceutical formulations and spiked urine samples had been determined successfully.

  1. A study of selective spectrophotometric methods for simultaneous determination of Itopride hydrochloride and Rabeprazole sodium binary mixture: Resolving sever overlapping spectra

    Science.gov (United States)

    Mohamed, Heba M.

    2015-02-01

    Itopride hydrochloride (IT) and Rabeprazole sodium (RB) are co-formulated together for the treatment of gastro-esophageal reflux disease. Three simple, specific and accurate spectrophotometric methods were applied and validated for simultaneous determination of Itopride hydrochloride (IT) and Rabeprazole sodium (RB) namely; constant center (CC), ratio difference (RD) and mean centering of ratio spectra (MCR) spectrophotometric methods. Linear correlations were obtained in range of 10-110 μg/μL for Itopride hydrochloride and 4-44 μg/mL for Rabeprazole sodium. No preliminary separation steps were required prior the analysis of the two drugs using the proposed methods. Specificity was investigated by analyzing the synthetic mixtures containing the two cited drugs and their capsules dosage form. The obtained results were statistically compared with those obtained by the reported method, no significant difference was obtained with respect to accuracy and precision. The three methods were validated in accordance with ICH guidelines and can be used for quality control laboratories for IT and RB.

  2. Stability of Diphenhydramine Hydrochloride, Lorazepam, and Dexamethasone Sodium Phosphate in 0.9% Sodium Chloride Stored in Polypropylene Syringes.

    Science.gov (United States)

    Anderson, Collin R; Halford, Zachery; MacKay, Mark

    2015-01-01

    Chemotherapy induced nausea and vomiting is problematic for many patients undergoing chemotherapy. Multiple-drug treatments have been developed to mitigate chemotherapy induced nausea and vomiting. A patient-controlled infusion of diphenhydramine hydrochloride, lorazepam, and dexamethasone sodium phosphate has been studied in patients who are refractory to first-line therapy. Unfortunately, the physical and chemical compatibility of this three-drug combination is not available in the published literature. Chemical compatibility was evaluated using high-performance liquid chromatography with ultraviolet detection. Visual observation was employed to detect change in color, clarity, or gas evolution. Turbidity and pH measurements were performed in conjunction with visual observation at hours 0, 24, and 48. Results showed that diphenhydramine hydrochloride 4 mg/mL, lorazepam 0.16 mg/mL, and dexamethasone sodium phosphate 0.27 mg/mL in 0.9% sodium chloride stored in polypropylene syringes were compatible, and components retained greater than 95% of their original concentration over 48 hours when stored at room temperature.

  3. Efficient adsorption and visible-light photocatalytic degradation of tetracycline hydrochloride using mesoporous BiOI microspheres.

    Science.gov (United States)

    Hao, Rong; Xiao, Xin; Zuo, Xiaoxi; Nan, Junmin; Zhang, Weide

    2012-03-30

    A novel microsphere-like BiOI hierarchical material was successfully synthesized by a one-step solution method at room temperature using polyvinylpyrrolidone (PVP) as structure directing reagent, its morphology, structure, surface area, photoabsorption were characterized, and the removal of tetracycline hydrochloride (TC) was evaluated under dark adsorption and visible light irradiation. It was shown that the BiOI microspheres formed in the precursor solution with PVP exhibit a mesoporous surface layer, 28.1m(2)g(-1) surface area, 1.91 eV band gap energy (E(g) value), and twofold removal ability to tetracycline hydrochloride (TC), i.e. adsorptive separation and visible light photocatalytic degradation. The adsorption process of TC on BiOI microspheres can be described by pseudo-second-order kinetics model and both Freundlich and Langmuir equations well described the adsorption isotherm but the former is better. More importantly, the BiOI microspheres exhibit an excellent photocatalytic degradation and mineralization capability to TC under visible light irradiation, which comes from its electronic band structure, high surface area and high surface-to-volume ratio. In addition, the BiOI microspheres are stable during the reaction and can be used repeatedly, showing promising prospect for the treatment of TCs in future industrial application. Copyright © 2012 Elsevier B.V. All rights reserved.

  4. Determination of Propranolol Hydrochloride in Pharmaceutical Preparations Using Near Infrared Spectrometry with Fiber Optic Probe and Multivariate Calibration Methods

    Directory of Open Access Journals (Sweden)

    Jucelino Medeiros Marques Junior

    2015-01-01

    Full Text Available A method for determination of propranolol hydrochloride in pharmaceutical preparation using near infrared spectrometry with fiber optic probe (FTNIR/PROBE and combined with chemometric methods was developed. Calibration models were developed using two variable selection models: interval partial least squares (iPLS and synergy interval partial least squares (siPLS. The treatments based on the mean centered data and multiplicative scatter correction (MSC were selected for models construction. A root mean square error of prediction (RMSEP of 8.2 mg g−1 was achieved using siPLS (s2i20PLS algorithm with spectra divided into 20 intervals and combination of 2 intervals (8501 to 8801 and 5201 to 5501 cm−1. Results obtained by the proposed method were compared with those using the pharmacopoeia reference method and significant difference was not observed. Therefore, proposed method allowed a fast, precise, and accurate determination of propranolol hydrochloride in pharmaceutical preparations. Furthermore, it is possible to carry out on-line analysis of this active principle in pharmaceutical formulations with use of fiber optic probe.

  5. 21 CFR 522.2470 - Tiletamine hydrochloride and zolazepam hydrochloride for injection.

    Science.gov (United States)

    2010-04-01

    ... for use. It is used for restraint or for anesthesia combined with muscle relaxation in cats and in... recommended for such procedures as dentistry, treatment of abscesses, foreign body removal, and related...

  6. Major diseases manifesting by vestibular vertigo: Treatment and rehabilitation

    OpenAIRE

    2015-01-01

    Betahistine hydrochloride is the drug of choice for the treatment of vestibular vertigo in the presence of benign paroxysmal positional vertigo, Meniere's disease, and vestibular neuronitis. Effective combination therapy regimens that contain, along with drugs from other pharmacological groups, betahistine hydrochloride that improves blood circulation in the vestibular structures, accelerates vestibular compensation, and prevents recurrent dizzy spells, have been elaborated to treat central v...

  7. Thermosensitive periodontal sol of ciprofloxacin hydrochloride and serratiopeptidase: Pharmaceutical and mechanical analysis.

    Science.gov (United States)

    Singh, Kushal Pal; Chhabra, Gulshan; Sharma, Vijay; Pathak, Kamla

    2014-01-01

    The aim of the present work was to explore the development of a dual-controlled release periodontal system of a potent broad spectrum first-generation fluoroquinolone, ciprofloxacin, and the anti-inflammatory enzyme serratiopeptidase (STP). Based on 3(2) full factorial design, thermoreversible periodontal sols capable of controlled dual delivery of ciprofloxacin hydrochloride and STP were designed using pluronic F127 and carbopol 934P as thermosensitive gelling polymers. Sol gel transition characteristics, %cumulative drug release at 48(th) h and exvivo mucoadhesive strength were designated as dependent responses. The sols were mucoadhesive, syringeable, and inverted into gels at simulated periodontal cavity temperature. F9 with optimal drug release was identified as the best formulation. Extra design check point generated using Design Expert software 8.02 (Stat-Ease, USA) validated the experimental design. Textural analysis revealed that the developed sols were syringeable and spreadable enough for periodontal treatment so it can be expected that hardness and compressibility of sols would pose no problem during clinical application. The in vitro release behavior exhibited controlled release of both cipro HCl and STP (>90% release). A dual-controlled release thermoreversible periodontal sol of ciproflaxin and STP was successfully developed. Incorporation of STP as anti-inflammatory agent has the potential of developing a therapeutically efficacious system of cipro HCl for treatment of periodontal inflammatory anaerobic infections.

  8. Physical and Chemical Characterization of Poly(hexamethylene biguanide Hydrochloride

    Directory of Open Access Journals (Sweden)

    Luiz Henrique C. Mattoso

    2011-06-01

    Full Text Available We present the characterization of commercially available Poly(hexamethylene biguanide hydrochloride (PHMB, a polymer with biocidal activity and several interesting properties that make this material suitable as a building block for supramolecular chemistry and “smart” materials. We studied polymer structure in water solution by dynamic light scattering, surface tension and capacitance spectroscopy. It shows typical surfactant behavior due to amphiphilic structure and low molecular weight. Spectroscopic (UV/Vis, FT-NIR and thermal characterization (differential scanning calorimetry, DSC, and thermogravimetric analysis, TGA were performed to give additional insight into the material structure in solution and solid state. These results can be the foundation for more detailed investigations on usefulness of PHMB in new complex materials and devices.

  9. β-Cyclodextrin-promazine hydrochloride interaction: Conductometric and viscometric studies

    Directory of Open Access Journals (Sweden)

    Mohd. Sajid Ali

    2015-01-01

    Full Text Available Herein we have studied the interaction of β-cyclodextrin (β-CD with the amphiphilic drug promazine hydrochloride (PMZ by using conductimetry and viscometry. From the observed results it was concluded that critical micelle concentration (cmc of the pure drug was lower than the apparent critical micelle concentration (cmc∗ of the drug in the presence of β-CD. The cmc∗ increased on increasing the concentration of β-CD due to the encapsulation of the amphiphilic drug to the hydrophobic cavities of the β-CD which delayed the micelle formation. Viscosity of the solution decreased drastically on the addition of β-CD which further increased on increasing the drug solution. Free energies of micellization (ΔGmic were calculated with the help of degrees of micelle ionization and cmc obtained from the specific conductivity−[PMZ] plots. Micellization was found to be less spontaneous in the presence of cyclodextrin.

  10. Permanent-wave dermatitis: contact allergy to cysteamine hydrochloride.

    Science.gov (United States)

    Landers, Maeran C; Law, Sandra; Storrs, Frances J

    2003-09-01

    Cysteamine hydrochloride (CHC) is a newly recognized sensitizer found in permanent-wave solutions. We report the case of a hairdresser who was found to be allergic to CHC. Our allergic patient was patch-tested to various chemicals found in permanent-wave solutions, including CHC (1.0% in petrolatum). Patch-test reactions were positive to CHC, glyceryl thioglycolate, diglyceryl thioglycolate, p-phenylenediamine (PPD), and PPD through a piece of latex glove. Sixty-four controls to CHC (1.0% in petrolatum) had negative results. Household-weight latex gloves were protective against CHC allergy. Persons with CHC-waved hair were not allergic. CHC contained in "neutral" permanent-wave preparations has been used in American beauty salons since 1993. We briefly discuss the introduction and significance of CHC in permanent waves.

  11. [Characteristics and selectivity of photocatalytic-degradation of tetracycline hydrochloride].

    Science.gov (United States)

    Song, Chen-Yi; Yin, Da-Qiang

    2014-02-01

    The photocatalytic-degradation behavior of tetracycline hydrochloride (TTC) was studied. The catalyst used was photosensitive semiconductor titanium dioxide (TiO2). The results showed that the photocatalytic degradation of TTC was well fitted to first order reaction kinetics model, and the adsorption was the control step of the whole photocatalytic-degradation process, indicating that the main degradation path was the photocatalytic reaction of TTC adsorbed on the surface of TiO2. Besides, through photocatalytic-degradation of the mixed solution of TTC and sulfamethoxazole or amoxicillin, the degradation of the two antibiotics showed obvious selectivity when the pH, TiO2 dosage and other conditions were changed.

  12. FORMULATION AND EVALUATION OF SUSTAINED RELEASE PELLETS OF TRAMADOL HYDROCHLORIDE

    Directory of Open Access Journals (Sweden)

    Baskara Haripriya

    2013-02-01

    Full Text Available The aim of the present research is to develop and evaluate a better sustained release multiple unit pellets (MUP formulation of Tramadol hydrochloride. Dissolution and diffusion controlled systems have classically been of primary importance in oral delivery of medication because of their relative ease of production and cost compared with other methods of sustained or controlled delivery. Most of these systems are solids, although a few liquids and suspension have been recently introduced. The present work aimed at developing SR pellets of Tramadol HCl by Wurster process. FTIR studies showed no unacceptable extra peaks which confirm the absence of chemical interaction between the drug and polymer. Angle of repose, tapped density, bulk density values for the formulations were within the range which indicates that pellets prepared by Wurster process were satisfactory for further studies. The percentage drug content of Tramadol was determined by extraction with methanol and analyzed by using UV-visible spectrophotometer at 271nm.

  13. A multicenter, randomized, double-blind, placebo-controlled, 6-month trial of bupropion hydrochloride sustained-release tablets as an aid to smoking cessation in hospital employees

    DEFF Research Database (Denmark)

    Dalsgareth, Oli Jacob; Hansen, Niels-Christian Gerner; Søes-Petersen, Ulrik

    2004-01-01

    Despite changes in smoking behavior, one-third of the Danish population continues to smoke. Many of these smokers are hospital employees. This 6-month, multicenter, parallel group, randomized, double-blind, placebo-controlled study evaluated treatment with bupropion hydrochloride sustained release...... (Zyban) compared with placebo as an aid to smoking cessation in health care workers. A total of 336 hospital employees who smoked at least 10 cigarettes daily were randomized (2:1) to 7 weeks of treatment with bupropion (n=222) or placebo (n=114). All participants were motivated to quit smoking......% in the bupropion group and 18% in the placebo group, pinsomnia, and pruritus appeared...

  14. Design and Evaluation of Chronomodulated Drug Delivery of Tramadol Hydrochloride.

    Science.gov (United States)

    Alekya, Thota; Narendar, Dudhipala; Mahipal, Donthi; Arjun, Narala; Nagaraj, Banala

    2017-09-26

    Rheumatoid arthritis is an auto immune disease which requires chronotherapy as it occurs during early morning. Tramadol hydrochloride (TH) is an analgesic drug, used to treat rheumatoid arthritis. The aim of the present investigation was to develop chronomodulated drug delivery system of tramadol hydrochloride such that it releases the drug early in the morning, during which the symptoms of rheumatoid arthritis worsen. To develop chronomodulated drug delivery system of TH, initially core tablets of TH were prepared using three different supradisintegrants followed by coating with pH dependent polymer of Eudragit S100. The prepared core tablets are evaluated for physical parameters and an optimal system was identified. Further, coating composition of Eudragit S100 was optimized and coating tablets of TH was prepared. The prepared coated tablets were evaluated for weight variation, hardness, drug content and in vitro release studies in 0.1N HCl, pH 6.8 phosphate buffer and pH 7.4 phosphate buffer. Formulation with 7.5% of coating solution (ES2) had shown a significant drug release after a lag time of 3 h (in pH 6.8 medium), 6 h (in pH 6.8 medium) and 8 h (in pH 7.4 medium), respectively. DSC studies revealed that no interaction between core and coated materials with drug was observed. Thus, chronomodulated drug delivery system of TH was formulated and assuming that if a tablet is administered around 9 pm to 10 pm, the drug release starts after a lag time of 6 h i. e., around 3am to 4 am. © Georg Thieme Verlag KG Stuttgart · New York.

  15. Formulation optimization of propranolol hydrochloride microcapsules employing central composite design

    Directory of Open Access Journals (Sweden)

    Shivakumar H

    2008-01-01

    Full Text Available A central composite design was employed to produce microcapsules of propranolol hydrochloride by o/o emulsion solvent evaporation technique using a mixture of cellulose acetate butyrate as coat material and span-80 as an emulsifier. The effect of formulation variables namely levels of cellulose acetate butyrate (X 1 and percentage of Span-80 (X 2 on encapsulation efficiency (Y 1 , drug release at the end of 1.5 h (Y 2 , 4 h (Y 3 , 8 h (Y 4 , 14 h (Y 5 , and 24 h (Y 6 were evaluated using the F test. Mathematical models containing only the significant terms were generated for each response parameter using multiple linear regression analysis and analysis of variance. Both the formulation variables exerted a significant influence (P < 0.05 on Y 1 whereas the cellulose acetate butyrate level emerged as the lone factor which significantly influenced the other response parameters. Numerical optimization using desirability approach was employed to develop an optimized formulation by setting constraints on the dependent and independent variables. The experimental values of Y 1 , Y 2 , Y 3 , Y 4 , Y 5 , and Y 6 for the optimized formulation was found to be 92.86±1.56% w/w, 29.58±1.22%, 48.56±2.56%, 60.85±2.35%, 76.23±3.16% and 95.12±2.41%, respectively which were in close agreement with those predicted by the mathematical models. The drug release from microcapsules followed first order kinetics and was characterized by Higuchi diffusion model. The optimized microcapsule formulation developed was found to comply with the USP drug release test-1 for extended release propranolol hydrochloride capsules.

  16. Biowaiver monographs for immediate release solid oral dosage forms: ciprofloxacin hydrochloride.

    Science.gov (United States)

    Olivera, M E; Manzo, R H; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2011-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of new multisource and reformulated immediate release (IR) solid oral dosage forms containing ciprofloxacin hydrochloride as the only active pharmaceutical ingredient (API) are reviewed. Ciprofloxacin hydrochloride's solubility and permeability, its therapeutic use and index, pharmacokinetics, excipient interactions and reported BE/bioavailability (BA) problems were taken into consideration. Solubility and BA data indicate that ciprofloxacin hydrochloride is a BCS Class IV drug. Therefore, a biowaiver based approval of ciprofloxacin hydrochloride containing IR solid oral dosage forms cannot be recommended for either new multisource drug products or for major scale-up and postapproval changes (variations) to existing drug products.

  17. Co-Amorphous Combination of Nateglinide-Metformin Hydrochloride for Dissolution Enhancement

    National Research Council Canada - National Science Library

    Wairkar, Sarika; Gaud, Ram

    The aim of the present work was to prepare a co-amorphous mixture (COAM) of Nateglinide and Metformin hydrochloride to enhance the dissolution rate of poorly soluble Nateglinide. Nateglinide (120 mg...

  18. Myocardial perfusion imaging with higenamine hydrochloride stress studies in diagnosis of coronary artery disease

    Institute of Scientific and Technical Information of China (English)

    周维

    2013-01-01

    Objective To evaluate the stress test efficacy and safety of higenamine hydrochloride,MPI studies were performed in patients with coronary artery disease. Methods Sixty-eight patients with suspected coronary artery

  19. Synthesis of 2-Heterocyclomethyl-5-diphenylmethylenecyclopentanone Hydrochlorides and their Inhibitory Effect on Tumor Cell Growth

    Institute of Scientific and Technical Information of China (English)

    Yun Hai ZHANG; Lin Xiang ZHAO; Zhen Jun BIAN; Rui WANG; Fu Yuan SUN

    2006-01-01

    Sixteen new 2-heterocyclomethyl-5-diphenylmethylenecyclopentanone hydrochlorides were designed and synthesized. The growth inhibitory effect of these compounds in vitro was conducted using a MTT assay in human breast cancer T47D cells.

  20. The effect of tramadol hydrochloride on early life stages of fish.

    Science.gov (United States)

    Sehonova, Pavla; Plhalova, Lucie; Blahova, Jana; Berankova, Petra; Doubkova, Veronika; Prokes, Miroslav; Tichy, Frantisek; Vecerek, Vladimir; Svobodova, Zdenka

    2016-06-01

    The aim of this study was to perform the fish embryo acute toxicity test (FET) on zebrafish (Danio rerio) and the early-life stage toxicity test on common carp (Cyprinus carpio) with tramadol hydrochloride. The FET was performed using the method inspired by the OECD guideline 236. Newly fertilized zebrafish eggs were exposed to tramadol hydrochloride at concentrations of 10; 50; 100 and 200μg/l for a period of 144h. An embryo-larval toxicity test on C. carpio was performed according to OECD guideline 210 also with tramadol hydrochloride at concentrations 10; 50; 100 and 200μg/l for a period of 32 days. Hatching was significantly influenced in both acute and subchronic toxicity assays. Subchronic exposure also influenced early ontogeny, both morphometric and condition characteristics and caused changes in antioxidant enzyme activity. The LOEC value was found to be 10μg/l tramadol hydrochloride.

  1. Effects of drotaverine hydrochloride on viability of rat cultured cerebellar granulocytes.

    Science.gov (United States)

    Demushkin, V P; Zhavoronkova, E V; Khaspekov, L G

    2012-02-01

    The neurocytotoxic effect of drotaverine hydrochloride was studied in culture of rat cerebellar granulocytes. Incubation of cells with 100 and 250 μM drotaverine reduced neuronal survival to 60 and 4%, respectively.

  2. Thiamine hydrochloride: An efficient catalyst for one-pot synthesis of quinoxaline derivatives at ambient temperature

    Indian Academy of Sciences (India)

    Omprakash B Pawar; Fulchand R Chavan; Venkat S Suryawanshi; Vishnu S Shinde; Narayan D Shinde

    2013-01-01

    Quinoxaline derivatives have been synthesized in high to excellent yields in the presence of thiamine hydrochloride (VB1) as an inexpensive, non-toxic and metal ion free catalyst at ambient temperature.

  3. Synthesis of imidazol-1-yl-acetic acid hydrochloride: A key intermediate for zoledronic acid

    OpenAIRE

    Singh, Santosh Kumar; Manne, Narendra; Ray, Purna Chandra; Pal, Manojit

    2008-01-01

    A convenient and practical synthesis of imidazol-1-yl-acetic acid hydrochloride was achieved via N-alkylation of imidazole using tert-butyl chloroacetate followed by a non-aqueous ester cleavage of the resulting imidazol-1-yl-acetic acid tert-butyl ester in the presence of titanium tetrachloride. The synthesized imidazol-1-yl-acetic acid hydrochloride was then utilized to prepare zoledronic acid.

  4. Synthesis of imidazol-1-yl-acetic acid hydrochloride: A key intermediate for zoledronic acid

    Science.gov (United States)

    Manne, Narendra; Ray, Purna Chandra

    2008-01-01

    Summary A convenient and practical synthesis of imidazol-1-yl-acetic acid hydrochloride was achieved via N-alkylation of imidazole using tert-butyl chloroacetate followed by a non-aqueous ester cleavage of the resulting imidazol-1-yl-acetic acid tert-butyl ester in the presence of titanium tetrachloride. The synthesized imidazol-1-yl-acetic acid hydrochloride was then utilized to prepare zoledronic acid. PMID:19104672

  5. Co-Amorphous Combination of Nateglinide-Metformin Hydrochloride for Dissolution Enhancement.

    Science.gov (United States)

    Wairkar, Sarika; Gaud, Ram

    2016-06-01

    The aim of the present work was to prepare a co-amorphous mixture (COAM) of Nateglinide and Metformin hydrochloride to enhance the dissolution rate of poorly soluble Nateglinide. Nateglinide (120 mg) and Metformin hydrochloride (500 mg) COAM, as a dose ratio, were prepared by ball-milling technique. COAMs were characterized for saturation solubility, amorphism and physicochemical interactions (X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR)), SEM, in vitro dissolution, and stability studies. Solubility studies revealed a sevenfold rise in solubility of Nateglinide from 0.061 to 0.423 mg/ml in dose ratio of COAM. Solid-state characterization of COAM suggested amorphization of Nateglinide after 6 h of ball milling. XRPD and DSC studies confirmed amorphism in Nateglinide, whereas FTIR elucidated hydrogen interactions (proton exchange between Nateglinide and Metformin hydrochloride). Interestingly, due to low energy of fusion, Nateglinide was completely amorphized and stabilized by Metformin hydrochloride. Consequently, in vitro drug release showed significant increase in dissolution of Nateglinide in COAM, irrespective of dissolution medium. However, little change was observed in the solubility and dissolution profile of Metformin hydrochloride, revealing small change in its crystallinity. Stability data indicated no traces of devitrification in XRPD of stability sample of COAM, and % drug release remained unaffected at accelerated storage conditions. Amorphism of Nateglinide, proton exchange with Metformin hydrochloride, and stabilization of its amorphous form have been noted in ball-milled COAM of Nateglinide-Metformin hydrochloride, revealing enhanced dissolution of Nateglinide. Thus, COAM of Nateglinide-Metformin hydrochloride system is a promising approach for combination therapy in diabetic patients.

  6. SIMULTANEOUS ESTIMATION OF DICLOFENAC SODIUM AND TOLPERISONE HYDROCHLORIDE IN COMBINED PHARMACEUTICAL FORMULATION

    OpenAIRE

    Bhavesh Gevriya* and R.C. Mashru

    2013-01-01

    Three simple, rapid, precise and accurate spectrophotometric methods have been developed for simultaneous analysis of Tolperisone Hydrochloride (TOL) and Diclofenac Sodium (DIC) in their combined dosage form. Method A, Simultaneous equation method (Vierodt’s method) applies measurement of absorptivities at two wavelengths, 261.00 nm (λmax of Tolperisone Hydrochloride) and 279.00 nm, (λmax of Diclofenac Sodium) in zero order spectra. The concentrations can be calculated from the derived equati...

  7. SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TOLPERISONE HYDROCHLORIDE AND DICLOFENAC SODIUM IN SYNTHETIC MIXTURE

    OpenAIRE

    Patel Satish A; Hariyani Kaushik P

    2012-01-01

    The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of Diclofenac sodium and Tolperisone hydrochloride in bulk and synthetic mixture. The method is based on the simultaneous equations for analysis of both the drugs using methanol as solvent. Diclofenac sodium has absorbance maxima at 281 nm and Tolperisone hydrochloride has absorbance maxima at 255 nm in methanol. The linearity was obtained in...

  8. The effect of L-ornithine hydrochloride ingestion on human growth hormone secretion after strength training

    OpenAIRE

    2010-01-01

    This study aimed to examine the effect of L-ornithine hydrochloride ingestion on serum growth hormone secretion response after strength training in young men who did not regularly engage in high intensity exercise. Ten healthy young males without workout habits (age: 22.2 +/- 1.0 yr). Subjects performed biceps curl strength training after L-ornithine hydrochloride and placebo ingestions. They participated in both of the above conditions randomly with a week interval in between. Serum growth h...

  9. Induction of blindness by formoguanamine hydrochloride in adult male roseringed parakeets (Psittacula krameri)

    Indian Academy of Sciences (India)

    Anamika Sengupta; Yoshihiko Obara; Tapan K Banerji; Saumen K Maitra

    2002-12-01

    Formoguanamine (2,4-diamino-s-triazine) was known to be an effective chemical agent in inducing blindness in poultry chicks, but not in adult birds. The present study was undertaken to demonstrate the influences, if any, of this chemical on the visual performance and retinal histology in an adult sub-tropical wild bird, the roseringed parakeet (Psittacula krameri). Formoguanamine (FG) hydrochloride was subcutaneously injected into adult parakeets at a dosage of 25 mg (dissolved in 0×75 ml physiological saline)/100 g body weight/day, for two consecutive days while the control birds were injected only with a placebo. The effects were studied after 10, 20 and 30 days of the last treatment of FG. Within 24 h of the treatment of FG, about 90% of the total birds exhibited lack of visual responses to any light stimulus and even absence of pupillary light reactions. The remaining birds became totally blind on the day following the last injection of FG and remained so till the end of investigation. At the microscopic level, conspicuous degenerative changes were noted in the outer pigmented epithelium and the photoreceptive layer of rods and cones in the retinas of FG treated birds. A significant reduction in the thickness of the outer nuclear layer was also found in the retinas of FG treated parakeets, compared to that in the control birds. However, the inner cell layers of the retina in the control and FG administered parakeets were almost identical. It deserves special mention that the effects of FG, noted after 30 days of last treatment, were not very different from those noted just after 10 days of treatment. Collectively, the results of the present investigation demonstrate that FG can be used as a potent pharmacological agent for inducing irreversible blindness through selective damage in retinal tissue even in the adult wild bird, thereby making FG treatment an alternative euthanasic device to a cumbersome, stressful, surgical method of enucleation of the ocular

  10. Direct, preparative enantioselective chromatography of propranolol hydrochloride and thioridazine hydrochloride using carbon dioxide-based mobile phases.

    Science.gov (United States)

    Geiser, F; Schultz, M; Betz, L; Shaimi, M; Lee, J; Champion, W

    1999-12-31

    In this paper, we describe the direct, preparative enantioselective chromatography of racemic (rac)-propranolol hydrochloride (HCI) and rac-thioridazine.HCl using Chiralpak AD chiral stationary phase and mobile phase systems containing carbon dioxide and methanol without the use of basic or acidic additives. Isolated fractions of propranolol.HCl were positively identified by mass spectrometry, Beilstein flame test, melting point, and chemical analysis to be HCI enantiomers of propranolol-HCl salts exhibited characteristic mass spectra peaks at 36 and 38 mass-to-charge ratio in the expected 3:1 isotopic ratio for the solute that were absent in the mass spectra for the free-base forms. To our knowledge, the direct, preparative enantioselective isolation of HCI enantiomeric salts of rac-propranolol and of rac-thioridazine have not been previously demonstrated and published.

  11. Using crystal structure prediction to rationalize the hydration propensities of substituted adamantane hydrochloride salts.

    Science.gov (United States)

    Mohamed, Sharmarke; Karothu, Durga Prasad; Naumov, Panče

    2016-08-01

    The crystal energy landscapes of the salts of two rigid pharmaceutically active molecules reveal that the experimental structure of amantadine hydrochloride is the most stable structure with the majority of low-energy structures adopting a chain hydrogen-bond motif and packings that do not have solvent accessible voids. By contrast, memantine hydrochloride which differs in the substitution of two methyl groups on the adamantane ring has a crystal energy landscape where all structures within 10 kJ mol(-1) of the global minimum have solvent-accessible voids ranging from 3 to 14% of the unit-cell volume including the lattice energy minimum that was calculated after removing water from the hydrated memantine hydrochloride salt structure. The success in using crystal structure prediction (CSP) to rationalize the different hydration propensities of these substituted adamantane hydrochloride salts allowed us to extend the model to predict under blind test conditions the experimental crystal structures of the previously uncharacterized 1-(methylamino)adamantane base and its corresponding hydrochloride salt. Although the crystal structure of 1-(methylamino)adamantane was correctly predicted as the second ranked structure on the static lattice energy landscape, the crystallization of a Z' = 3 structure of 1-(methylamino)adamantane hydrochloride reveals the limits of applying CSP when the contents of the crystallographic asymmetric unit are unknown.

  12. RP-HPLC estimation of imipramine hydrochloride and diazepam in tablets

    Directory of Open Access Journals (Sweden)

    D Srikantha

    2015-01-01

    Full Text Available A simple and rapid reversed phase-high performance liquid chromatographic method was developed for simultaneous determination of imipramine hydrochloride and diazepam in pharmaceutical formulations. The elution was done in isocratic mode utilizing a mobile phase consisting of methanol:water:0.1M sodium acetate (30:50:20 v/v/v on Chromosil C18 column with a flow rate of 1.0 ml/min and with detection at 243 nm. The measured retention time was 3.33±0.02 min for imipramine hydrochloride and 4.64±0.02 min for diazepam. Linearity was measured in the range 25-150 μg/ml for imipramine hydrochloride (r 2 =0.999 and in the range 5-30 μg/ml for diazepam (r 2 =0.9994, respectively. The limits of detection and quantitation were 0.03 and 0.1 μg/ml for imipramine hydrochloride and 0.02 and 0.07 μg/ml for diazepam. Satisfactory validation was also obtained from recovery (100.95-101.52% for imipramine hydrochloride and 99.47-100.33% for diazepam studies, intraday and interday precision (<2% and robustness results. The reported method was the first study of these drugs in combination and could be employed for routine quantitative determination of imipramine hydrochloride and diazepam in tablets.

  13. HPLC method validation for modernization of the tetracycline hydrochloride capsule USP monograph

    Directory of Open Access Journals (Sweden)

    Emad M. Hussien

    2014-12-01

    Full Text Available This paper is a continuation to our previous work aiming at development and validation of a reversed-phase HPLC for modernization of tetracycline-related USP monographs and the USP general chapter . Previous results showed that the method is accurate and precise for the assay of tetracycline hydrochloride and the limit of 4-epianhydrotetracycline impurity in the drug substance and oral suspension monographs. The aim of the current paper is to examine the feasibility of the method for modernization of USP tetracycline hydrochloride capsule monograph. Specificity, linearity, accuracy and precision were examined for tetracycline hydrochloride assay and 4-epianhydrotetracycline limit. The method was linear in the concentration range from 80% to 160% (r>0.9998 of the assay concentration (0.1 mg/mL for tetracycline hydrochloride and from 50% to 150% (r>0.997 of the acceptance criteria specified in tetracycline hydrochloride capsule monograph for 4-epianhydrotetracycline (NMT 3.0%. The recovery at three concentration levels for tetracycline hydrochloride assay was between 99% and 101% and the RSD from six preparations at the concentration 0.1 mg/mL is less than 0.6%. The recovery for 4-epianhydrotetracycline limit procedure over the concentration range from 50% to 150% is between 96% and 102% with RSD less than 5%. The results met the specified acceptance criteria.

  14. SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TOLPERISONE HYDROCHLORIDE AND DICLOFENAC SODIUM IN SYNTHETIC MIXTURE

    Directory of Open Access Journals (Sweden)

    Patel Satish A

    2012-09-01

    Full Text Available The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of Diclofenac sodium and Tolperisone hydrochloride in bulk and synthetic mixture. The method is based on the simultaneous equations for analysis of both the drugs using methanol as solvent. Diclofenac sodium has absorbance maxima at 281 nm and Tolperisone hydrochloride has absorbance maxima at 255 nm in methanol. The linearity was obtained in the concentration range of 2-20 μg/ml and 2-20 μg/ml for Diclofenac sodium and Tolperisone hydrochloride, respectively. The concentrations of the drugs were determined by using simultaneous equations at both the wavelengths. The mean recovery was 100.6 ± 0.41 and 99.64 ± 0.50 for Diclofenac sodium and Tolperisone hydrochloride, respectively. The method was successfully applied to laboratory prepared synthetic mixture because no interference from the mixture excipients was found. The suitability of this method for the quantitative determination of Diclofenac sodium and Tolperisone hydrochloride was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of Diclofenac sodium and Tolperisone hydrochloride in combination. The results of analysis have been validated statistically and by recovery studies.

  15. Stability-indicating HPLC method for simultaneous determination of montelukast and fexofenadine hydrochloride

    Directory of Open Access Journals (Sweden)

    Mona Pankhaniya

    2013-01-01

    Full Text Available A simple, specific, accurate, and stability-indicating reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of montelukast and fexofenadine hydrochloride, using a Lichrospher ® 100, RP-18e column and a mobile phase composed of methanol:0.1% o-phosphoric acid (90:10 v/v, pH 6.8. The retention times of montelukast and fexofenadine hydrochloride were found to be 10.16 and 12.03 min, respectively. Linearity was established for montelukast and fexofenadine hydrochloride in the range of 2-10 μg/ml and 24-120 μg/ml, respectively. The percentage recoveries of montelukast and fexofenadine hydrochloride were found to be in the range of 99.09 and 99.81%, respectively. Both the drugs were subjected to acid and base hydrolysis, oxidation, photolytic, and thermal degradation conditions. The degradation products of montelukast and fexofenadine hydrochloride were well resolved from the pure drug with significant differences in their retention time values. This method can be successfully employed for simultaneous quantitative analysis of montelukast and fexofenadine hydrochloride in bulk drugs and formulations.

  16. Comparison between lignocaine hydrochloride and ropivacaine hydrochloride as lumbosacral epidural anaesthetic agents in goats undergoing laparoscopy assisted embryo transfer

    Directory of Open Access Journals (Sweden)

    Anubhav Khajuria

    2014-10-01

    Full Text Available Goats (n=12 undergoing laparoscopy assisted embryo transfer were randomly allotted to two groups (I and II and injected lignocaine hydrochloride (4mg/kg or ropivacaine hydrochloride (1mg/kg at the lumbosacral epidural space. The animals were held with raised hind quarters for first three minutes following injection. Immediately after induction of regional anaesthesia, they were restrained in dorsal recumbency in Trendelenburg position in a cradle. Laparoscopy was performed after creating pneumoperitoneum using filtered room air. The mean (± S.E induction time in animals of group I was significantly shorter (5.33 ± 0.61 min than those belonging to group II (12.66 ±1.99 min. Complete analgesia developed throughout the hind quarters and abdomen for 30 min and 60 min in group I and II animal’s respectively. Unlike animals of group I, group II goats continued to show moderate analgesia for 180 minutes. The motor activity returned after a lapse of 130.00 ± 12.64 min and 405.00 ± 46.31 min respectively. Occasional vocalization and struggling was noticed in two goats one from each group irrespective of the surgical manipulations during laparoscopy. The rectal temperature and respiration rates showed only non-significant increase, but the heart rate values were significantly higher (P < 0.5 up to 150 min in animals of both the groups when compared to their baseline values. From this study, it was concluded that both anaesthetic agents produced satisfactory regional anaesthesia in goats undergoing laparoscopy. However, considering the very long delay in regaining the hind limb motor activity, the use of ropivacaine may not be recommended for this purpose. Supplementation of sedative/tranquilizer with lumbosacral epidural anaesthesia needs evaluation.

  17. Biowaiver monographs for immediate release solid oral dosage forms based on biopharmaceutics classification system (BCS) literature data: verapamil hydrochloride, propranolol hydrochloride, and atenolol.

    Science.gov (United States)

    Vogelpoel, H; Welink, J; Amidon, G L; Junginger, H E; Midha, K K; Möller, H; Olling, M; Shah, V P; Barends, D M

    2004-08-01

    Literature data related to the Biopharmaceutics Classification System (BCS) are presented on verapamil hydrochloride, propranolol hydrochloride, and atenolol in the form of BCS-monographs. Data on the qualitative composition of immediate release (IR) tablets containing these active substances with a Marketing Authorization (MA) in the Netherlands (NL) are also provided; in view of these MA's the assumption was made that these tablets were bioequivalent to the innovator product. The development of a database with BCS-related data is announced by the International Pharmaceutical Federation (FIP).

  18. An enantioselective synthesis of S-[gamma]-[(4-trifluoromethyl)phenoxy]benzenepropanamine-[3-[sup 14]C] hydrochloride, an important metabolite of fluoxetine hydrochloride

    Energy Technology Data Exchange (ETDEWEB)

    Wheeler, W.J. (Lilly (Eli) and Co., Indianapolis, IN (United States). Lilly Research Labs.)

    1992-06-01

    The S-enantiomer of [gamma]-[(4-trifluoromethyl)phenoxy]benzenepropanamine-[3-[sup 14]C] hydrochloride has been prepared in eight steps from acetophenone-[carbonyl-[sup 14]C]. The key step in the synthesis involved the enantioselective reduction of R-2-chloroacetophenone-[1-[sup 14]C]with (-)-diisopinocampheyl-chloroborane in an 86.5% yield. The chlorohydrin was converted to R-phenyloxirane-[1-[sup 14]C], which was subsequently converted to the corresponding R-cyanohydrin by reaction with TMS-CN/CaO. Borane reduction and arylation, followed by salt formation yielded S-[gamma]-[(4-trifluoromethyl)phenoxy]benzenepropanamine-[3-[sup 14]C] hydrochloride. (author).

  19. Development and Characterization of Nanoparticles for the Delivery of Gemcitabine Hydrochloride

    Directory of Open Access Journals (Sweden)

    Rekha Khaira

    2014-01-01

    Full Text Available Gemcitabine (2,2-difluorodeoxycytidine is a deoxycytidine analog, currently being used as a first-choice drug in pancreatic metastatic cancer. Gemcitabine is administered weekly as 30-minute infusion with starting dose ranging from 800 to 1250 mg/m2. The aim of the present work was to develop starch nanoparticles (NPs for the delivery of gemcitabine hydrochloride that could reduce its dose related side effects and may prolong its retention time (24 hrs for the treatment of pancreatic cancer. Nanoparticles were prepared by emulsification diffusion method with slight modifications. Size and morphology of nanoparticles were investigated. Particles were spherical in shape with slightly rough surfaces. Particle size and polydispersity index were 231.4 nm and 1.0, respectively while zeta potential of blank NPs and drug loaded NPs were found to be −11.8 mV and −9.55 mV, respectively. Percent entrapment efficiency of different formulations was around ∼54% to 65%. In vitro release profile studies showed that around 70%–83% of drug was released from different formulations. Anticancerous cell line studies were also performed in human pancreatic cell lines (MIA-PA-CA-2.

  20. [Effect of olopatadine hydrochloride, a novel antiallergic agent, on the QT interval in dogs].

    Science.gov (United States)

    Iwamoto, K; Ikeda, J; Nito, M; Kosaka, N; Ichikawa, S; Kobayashi, H; Ohmori, K

    2001-06-01

    Olopatadine hydrochloride (olopatadine), a novel antiallergic agent, is effective in the treatment of allergic rhinitis, chronic urticaria, eczema and dermatitis. It has been reported that terfenadine and astemizole cause side effects on the circulatory system such as QT prolongation followed by serious ventricular arrhythmias (torsades de pointes). To investigate the possibility of QT prolongation, we used both conscious normal dogs and hypokalemia-anesthetized dogs under two conditions: 1) olopatadine used alone and 2) olopatadine used in combination with itraconazole, the CYP3A4-inhibiting antifungal agent, in the present investigation. The group treated with terfenadine alone (30 mg/kg, p.o.) and the group treated with a combination of terfenadine (10 mg/kg, p.o.) and itraconazole (100 mg/kg, p.o.) had a significantly prolonged QT interval. On the other hand, the group treated with olopatadine alone (30 mg/kg, p.o.) and the group treated with a combination of olopatadine (30 mg/kg, p.o.) and itraconazole (100 mg/kg, p.o.) did not show any significant changes in QT interval. Moreover, olopatadine (1 and 5 mg/kg, i.v.) did not influence the QT interval in hypokalemia-anesthetized dogs. These results suggest that there is very little possibility of QT prolongation as a result of clinically used olopatadine.

  1. Ephedrine hydrochloride protects mice from LPS challenge by promoting IL-10 secretion and inhibiting proinflammatory cytokines.

    Science.gov (United States)

    Zheng, Yuejuan; Guo, Ziyi; He, Weigang; Yang, Yang; Li, Yuhu; Zheng, Aoxiang; Li, Ping; Zhang, Yan; Ma, Jinzhu; Wen, Mingyue; Yang, Muyi; An, Huazhang; Ji, Guang; Yu, Yizhi

    2012-05-01

    Sepsis and its derivative endotoxic shock are still serious conditions with high mortality in the intensive care unit. The mechanisms that ensure the balance of proinflammatory cytokines and anti-inflammatory cytokine production are of particular importance. As an active α- and β-adrenergic agonist, ephedrine hydrochloride (EH) is a widely used agent for cardiovascular diseases, especially boosting blood pressure. Here we demonstrate that EH increased Toll-like receptor 4 (TLR4)-mediated production of interleukin 10 (IL-10) through p38 MAPK activation. Simultaneously, EH negatively regulated the production of proinflammatory cytokines. Consistently, EH increased lipopolysaccharide (LPS)-induced serum IL-10 and inhibited tumor necrotic factor-α (TNFα) production in vivo. As a result, EH treatment protected mice from endotoxic shock by lethal LPS challenge. In brief, our data demonstrated that EH could contribute to immune homeostasis by balancing the production of proinflammatory cytokines and anti-inflammatory cytokine in TLR4 signaling. This study provides a potential usage of EH in autoimmunologic diseases or other severe inflammations.

  2. Does benzydamine hydrochloride applied preemptively reduce sore throat due to laryngeal mask airway?

    Science.gov (United States)

    Kati, Ismail; Tekin, Murat; Silay, Emin; Huseyinoglu, Urfettin A; Yildiz, Huseyin

    2004-09-01

    Sore throat is a common postoperative complaint. We investigated whether preemptive benzydamine hydrochloride (BH) treatment could prevent sore throat due to a laryngeal mask airway (LMA) cuff inflated with air. One-hundred ASA status I-II patients who underwent general anesthesia were randomly divided into two groups. In the first group, four puffs of BH were applied to the pharynx 30 min before the operation and 5 min before the induction of anesthesia. Distilled water with a similar bottle was applied with the same protocol in the second group. Anesthetic induction was provided with propofol and fentanyl. The pressure of the LMA cuff inflated with room air was measured after the first adjustment and after 30, 60, and 90 min of inflation in both groups. At the end of operation, the LMA was removed after the recovery of spontaneous breathing. After the operation, patients were asked about sore throat symptoms at the first, second, and fourth hours. There were no significant differences between groups for cuff pressures, cuff volumes, analgesic doses, or operation times. However, sore throat symptoms were significantly less severe for the BH group during both resting and swallowing. In conclusion, preemptive topical BH may decrease the incidence of sore throat due to LMA use.

  3. Simultaneous determination of Fluticasone propionate and Azelastine hydrochloride in the presence of pharmaceutical dosage form additives

    Science.gov (United States)

    Merey, Hanan A.; El-Mosallamy, Sally S.; Hassan, Nagiba Y.; El-Zeany, Badr A.

    2016-05-01

    Fluticasone propionate (FLU) and Azelastine hydrochloride (AZE) are co-formulated with phenylethyl alcohol (PEA) and Benzalkonium chloride (BENZ) (as preservatives) in pharmaceutical dosage form for treatment of seasonal allergies. Different spectrophotometric methods were used for the simultaneous determination of cited drugs in the dosage form. Direct spectrophotometric method was used for determining of AZE, while Derivative of double divisor of ratio spectra (DD-RS), Ratio subtraction coupled with ratio difference method (RS-RD) and Mean centering of the ratio spectra (MCR) are used for the determination of FLU. The linearity of the proposed methods was investigated in the range of 5.00-40.00 and 5.00-80.00 μg/mL for FLU and AZE, respectively. The specificity of the developed methods was investigated by analyzing laboratory prepared mixtures containing different ratios of cited drugs in addition to PEA and their pharmaceutical dosage form. The validity of the proposed methods was assessed using the standard addition technique. The obtained results were statistically compared with those obtained by official or the reported method for FLU or AZE, respectively showing no significant difference with respect to accuracy and precision at p = 0.05.

  4. Thermoresponsive magnetic nanoparticle--aminated guar gum hydrogel system for sustained release of doxorubicin hydrochloride.

    Science.gov (United States)

    Murali, Ragothaman; Vidhya, Ponraj; Thanikaivelan, Palanisamy

    2014-09-22

    Hydrogel based sustained drug delivery system has evolved as an immense treatment method for solid tumors over the past few decades with long term theranostic ability. Here, we synthesized an injectable hydrogel system comprising biocompatible aminated guar gum, Fe3O4-ZnS core-shell nanoparticles and doxorubicin hydrochloride. We show that amination of guar gum resulted in attraction of water molecules thereby forming the hydrogel without using toxic crosslinking agents. Hydrogel formation was observed at 37°C and is stable up to 95°C. The prepared hydrogel is also stable over a wide pH range. The in vitro studies show that the maximum de-gelation and drug release up to 90% can be achieved after 20 days of incubation. Studies reveal that the drug and the core-shell nanoparticles can be released slowly from the hydrogel to provide the healing and diagnosis of the solid tumor thereby avoiding several drug administrations and total excision of organs.

  5. Formulation and evaluation of once daily minocycline hydrochloride extended release matrix tablets

    Directory of Open Access Journals (Sweden)

    Keny R

    2009-01-01

    Full Text Available The present study was aimed to develop once daily extended release matrix tablets of minocycline hydrochloride, using hydroxypropylmethylcellulose either alone or in combination with ethyl cellulose as the matrix material in different proportions. The formulated tablets were also compared with a marketed product. The results of the dissolution study indicate that formulations FC-IV, FC-V and FC-VI showed maximum drug release upto 24 h, whereas the marketed product was found to extend the release only up to 14 h. Incase of formulations containing combination of hydroxypropylmethylcellulose and ethyl cellulose (FC-I to FC-IX, the release of the drug was found to be dependent on the relative proportions of hydroxypropylmethylcellulose and ethyl cellulose used in the tablet matrix. Mathematical treatment of the in vitro drug release data suggests that, all the formulations best fitted into first order release kinetics. Drug release from the matrix occurred by combination of two mechanisms, diffusion of drug from tablet matrix and erosion of tablet surface, which was reflected from Higuchi′s model and Erosion plot.

  6. Bioequivalence Studies of a Reformulated Dutasteride and Tamsulosin Hydrochloride Combination Capsule and a Commercially Available Formulation.

    Science.gov (United States)

    Kurczewski, Renee; Bowen, Chet; Collins, David; Zhu, John; Serbest, Gulyeter; Manyak, Michael

    2017-01-27

    A dutasteride 0.5 mg and tamsulosin hydrochloride 0.4 mg combination (DTC) capsule (Duodart(®) ) was reformulated to reduce the capsule size and enhance product stability. Bioequivalence of the reformulated DTC capsule with the commercial formulation was evaluated in 2 single-dose, open-label, randomized, 2-way crossover studies in healthy adult male volunteers. Subjects in a fasted or fed state received a single oral dose of either the reformulated DTC or the commercial formulation followed by a 28-day washout period between treatments. Blood samples were taken predose and up to 72 hours postdose for pharmacokinetic (PK) analysis of dutasteride and tamsulosin serum concentrations. From the serum concentration-vs-time data, a noncompartmental method was used to calculate the maximum observed serum concentration (Cmax ) and area under the serum concentration-time curve (AUC0-t ) for dutasteride and tamsulosin, and AUC0-∞ for tamsulosin. The 90% confidence intervals for the ratios of the Cmax and AUC0-t (for dutasteride and tamsulosin) and for AUC0-∞ (for tamsulosin) were all completely contained within the range of 80% to 125%; therefore, the reformulated DTC capsule is bioequivalent to the commercial formulation under both fed and fasted states.

  7. Development and characterisation of thermo reversible mucoadhesive moxifloxacin hydrochloride in situ ophthalmic gel

    Directory of Open Access Journals (Sweden)

    M Dholakia

    2012-01-01

    Full Text Available A sustain release thermo reversible in situ gel of Moxifloxacin Hydrochloride using mucoadhesive polymer was prepared. Mucoadhesive polymer was used to obtain an ophthalmic delivery system with improved mechanical and mucoadhesive properties that will provide prolong retention time for treatment of ocular diseases. Developed formulations were evaluated for drug-excipient compatibility study, pH, Clarity, Gelation temperature study, Mucoadhesion properties and in-vitro release studies. Drug-excipient compatibility study was performed by FTIR technique.The individual IR spectra of the pure drug and polymers as well as the combination spectra of the drug and polymer were taken, which indicate no interaction between Moxifloxacin and polymers when compared with infrared spectrum of pure drug as all functional group frequencies were present. The values of other parameters obtained were in acceptable range. In vitro release tests revealed that 98% drug was released from the in situ gel containing 0.5% and 1.00% HPMC in 12 hr. provides prolonged release.

  8. Photocatalytic Destruction of Tetracycline Hydrochloride on the Surface of Titanium Dioxide Films Modified by Gold Nanoparticles

    Science.gov (United States)

    Linnik, O. P.; Zhukovskiy, M. A.; Starukh, G. N.; Smirnova, N. P.; Gaponenko, N. V.; Asharif, A. M.; Khoroshko, L. S.; Borisenko, V. E.

    2015-01-01

    Films of titania (TiO2) and titania modified with gold nanoparticles (TiO2:Au) were synthesized by a sol-gel method on substrates of glass, aluminum, and aluminum with a layer of nanotextured aluminum or porous anodic alumina. The photocatalytic activity of the samples was investigated in an aqueous solution of the antibiotic tetracycline hydrochloride (TC). TC decomposition was observed in the presence of all samples as a reduction of the solution optical density in the range below 500 nm. Titania was in the crystalline anatase phase with incorporated spherical gold nanoparticles primarily of sizes 1-10 nm after heat treatment at 400°C. Modification of TiO2 films with gold nanoparticles on glass or aluminum substrates did not increase the photocatalytic activity of the samples. It was found that complexes of TC with Al3+ in solution formed only in the presence of gold nanoparticles in the film either in the dark or with UV irradiation.

  9. Development and characterization of in-situ gel for ophthalmic formulation containing ciprofloxacin hydrochloride.

    Science.gov (United States)

    Makwana, S B; Patel, V A; Parmar, S J

    2016-01-01

    In situ gels are systems which are applied as solutions or suspensions and are capable of undergoing rapid sol-to-gel transformation triggered by external stimulus such as temperature, pH etc. on instillation. The aim of the present study was to formulate and evaluate pH responsive in-situ gel for ophthalmic delivery. Ciprofloxacin hydrochloride is popularly used as a broad spectrum antibiotic in the treatment of corneal ulcers of ocular infections. However, rapid dilution on instillation, wash out, poor retention of drug concentration delimit the therapeutic benefits of the drug when used in form of conventional eye drops. Sodium alginate, an ophthalmic gel forming mucoadhesive polymer was chosen as polymer which undergoes instantaneous gel formation due to formation of calcium alginate by virtue of its interaction with divalent cation (Ca(+2)) present in lachrymal fluid. Hydroxy Propyl Methyl Cellulose (HPMC K4M and E5 0LV) was further incorporated as a viscosity enhancer in order to achieve the desired consistency so as to facilitate sustained drug release. The developed formulations were evaluated for clarity, pH measurement, gelling capacity, drug content, rheological study, and in vitro drug release. Thus, in situ gel based systems containing gums can be a valuable approach for ophthalmic drug delivery when compared to conventional systems.

  10. Benzydamine hydrochloride buccal bioadhesive gels designed for oral ulcers: preparation, rheological, textural, mucoadhesive and release properties.

    Science.gov (United States)

    Karavana, Sinem Yaprak; Güneri, Pelin; Ertan, Gökhan

    2009-01-01

    This study developed and examined the characterization of Benzidamine hydrochloride (BNZ) bioadhesive gels as platforms for oral ulcer treatments. Bioadhesive gels were prepared with four different hydroxypropylmethylcellulose (HPMC) types (E5, E15, E50 and K100M) with different ratios. Each formulation was characterized in terms of drug release, rheological, mechanical properties and adhesion to a buccal bovine mucosa. Drug release was significantly decreased as the concentration and individual viscosity of each polymeric component increased due to improved viscosity of the gel formulations. The amount of drug released for the formulations ranged from 0.76 +/- 0.07 and 1.14 +/- 0.01 (mg/cm2 +/- SD). Formulations exhibited pseudoplastic flow and all formulations, increasing the concentration of HPMC content significantly raised storage modulus (G'), loss modulus (G''), dynamic viscosity (eta') at 37 degrees C. Increasing concentration of each polymeric component also significantly improved the hardness, compressibility, adhesiveness, cohesiveness and mucoadhesion but decreased the elasticity of the gel formulations. All formulations showed non-Fickian diffusion due to the relaxation and swelling of the polymers with water. In conclusion, the formulations studied showed a wide range of mechanical and drug diffusion characteristics. On the basis of the obtained data, the bioadhesive gel formulation which was prepared with 2.5% HPMC K 100M was determined as the most appropriate formulation for buccal application in means of possessing suitable mechanical properties, exhibiting high cohesion and bioadhesion.

  11. Pharmacokinetics and effect of food after oral administration of prolonged-release tablets of ropinirole hydrochloride in Japanese patients with Parkinson's disease.

    Science.gov (United States)

    Hattori, N; Hasegawa, K; Sakamoto, T

    2012-10-01

    Ropinirole hydrochloride, a dopamine receptor agonist with a non-ergot alkaloid structure, is highly selective for the dopamine D(2) /D(3) receptors. This study was conducted to evaluate the steady-state pharmacokinetics, safety and efficacy after repeated oral administration of prolonged-release tablets of ropinirole hydrochloride in the absence of L-dopa preparations in Japanese patients with Parkinson's disease (PD). This was a multicenter, open-label, uncontrolled study. The total duration of participation in the study ranged from 56 to 63 weeks. In the study, the plasma concentrations of ropinirole, its major metabolite SK&F104557 (N-depropyl ropinirole) and another metabolite SK&F89124 (ropinirole hydroxylated at the seventh position of the indole ring) were assessed. Safety based on adverse events, haematology, biochemistry, urinalysis and electrocardiography (ECG) (standard 12-lead ECG) were evaluated, and vital signs (blood pressure/pulse rate) were measured. Efficacy based on the Japanese version of Unified Parkinson's Disease Rating Scale (UPDRS) Parts III (motor) and II [activities of daily living (ADL)] as well as tolerability was evaluated. After repeated oral administration of prolonged-release tablets of ropinirole hydrochloride in Japanese patients with PD, ropinirole, SK&F104557 and low levels of SK&F89124 were detected in plasma. The trough concentrations of ropinirole and the two metabolites increased in proportion to the dose when ropinirole hydrochloride prolonged-release tablets were administered at doses ranging from 2 to 16 mg/day. The plasma exposure to ropinirole and its two metabolites after intake of normal diet was comparable to that in the fasting state. The most common adverse events (10% or more) were somnolence, nausea, constipation, hallucination and nasopharyngitis. Most adverse events were mild or moderate in severity, and with no death. During the treatment period, serious adverse events were reported in five patients. Efficacy

  12. Efficacy and local tolerability of povidone iodine and octenidine hydrochloride solution for the antiseptic preparation of the orificium urethrae.

    Science.gov (United States)

    Rudolph, P; Fritze, F; Reimer, K; Klebingat, K J; Kramer, A

    1999-01-01

    In a randomized clinical study, 61 hospitalized men were examined to test the local tolerability and antimicrobial efficacy of antiseptic treatment of the genitals with povidone iodine versus octenidine hydrochloride solution. Antibacterial efficacy was established by comparing the total aerobic bacterial colony count from standardized swabs from the orificium urethrae externum before, immediately after, and 30 and 60 min after antisepsis. Tolerability was assessed by dermatoscopy, applying a scale to rate the criteria of reddening, erosions and microbleeding. pH-value was taken and the nitracin yellow test carried out at several intervals. Patients assessed sensations (itching, burning, warmth, cold tension) in visual analogue scales. The test for equivalence in efficacy of both antiseptic agents produced no significant result (P = 0.3). The sum score of tolerability produced a better result for povidone iodine. In addition, the drop in the pH value after observed antisepsis with povidone iodine provides an additional protective mechanism against bacterial colonization.

  13. The guanidine hydrochloride-induced denaturation of CP43 and CP47 studied by terahertz time-domain spectroscopy

    Institute of Scientific and Technical Information of China (English)

    QU YuanGang; CHEN Hua; QIN XiaoChun; WANG Li; LI LiangBi; KUANG TingYun

    2007-01-01

    Terahertz time-domain spectroscopy (THz-TDS) is a new technique in studying the conformational state of a molecule in recent years. In this work, we reported the first use of THz-TDS to examine the denaturation of two photosynthesis membrane proteins: CP43 and CP47. THz-TDS was proven to be useful in discriminating the different conformational states of given proteins with similar structure and in monitoring the denaturation process of proteins. Upon treatment with guanidine hydrochloride (GuHCI),a 1.8 THz peak appeared for CP47 and free chlorophyll a (Chi a). This peak was deemed to originate from the interaction between Chli a and GuHCI molecules. The Chl a molecules in CP47 interacted with GuHCI more easily than those in CP43.

  14. The guanidine hydrochloride-induced denaturation of CP43 and CP47 studied by terahertz time-domain spectroscopy

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Terahertz time-domain spectroscopy (THz-TDS) is a new technique in studying the conformational state of a molecule in recent years. In this work, we reported the first use of THz-TDS to examine the dena- turation of two photosynthesis membrane proteins: CP43 and CP47. THz-TDS was proven to be useful in discriminating the different conformational states of given proteins with similar structure and in monitoring the denaturation process of proteins. Upon treatment with guanidine hydrochloride (GuHCl), a 1.8 THz peak appeared for CP47 and free chlorophyll a (Chl a). This peak was deemed to originate from the interaction between Chl a and GuHCl molecules. The Chl a molecules in CP47 interacted with GuHCl more easily than those in CP43.

  15. Effect of permeation enhancers on the release and permeation kinetics of Lincomycin hydrochloride gel formulations through mouse skin

    Directory of Open Access Journals (Sweden)

    Panigrahi L

    2006-01-01

    Full Text Available Lincomycin hydrochloride is a systemic antibiotic, which is active against most common gram positive bacteria. It has proved to be excellent for infectious diseases like acne, anthrax, pneumonia, and also for the treatment of furunculosis, carbuncles, impetigo, burns and wounds, carrying to gram positive bacteria. Gels were prepared using carbopol 940 as gelling agent, and isopropyl myristate and dimethyl sulfoxide as permeation enhancer. The formulations were evaluated for drug content, viscosity, pH, extrudability, homogeneity, skin irritation test, spreadability, and gel strength. A formulation containing 1.5% carbopol with 10% isopropyl myristate, showed better in vitro skin permeation through abdominal mouse skin, and was found to be the best.

  16. Simultaneous determination of toxic heavy metals in metformin hydrochloride using reversed-phase high-performance liquid chromatography

    Energy Technology Data Exchange (ETDEWEB)

    Steenkamp, P.A. (Dept. of Chemistry and Biochemistry, Rand Afrikaans Univ., Auckland Park (South Africa)); Coetzee, P.P. (Dept. of Chemistry and Biochemistry, Rand Afrikaans Univ., Auckland Park (South Africa))

    1993-08-01

    A rapid and sensitive reversed phase HPLC technique was developed for the determination of seven toxic heavy metals in biological matrices. Cd, Pb, Ni, Co, Bi, Cu and Hg could be detected and quantified at ppb level in Metformin hydrochloride, a pharmaceutical product used in the treatment of certain cases of diabetes. This was achieved by the evaluation of the stability of NaDEDTC in the presence of water and different buffers at different pH-values. A direct injection/on-column derivatization HPLC procedure was developed employing NaDEDTC as chelating agent, a C-18 reversed phase analytical column and a photodiode assay detector. Dilute metal ion solutions could be analyzed by direct injection of the test sample. The analysis of trace levels of metals in a pure pharmaceutical product however required the inclusion of a sample preparation step prior to analysis. (orig.)

  17. Observing the Efficacy of Diclofenac Sodium Lidocaine Hydrochloride on Severe Migraine%双氯芬酸钠/盐酸利多卡因治疗中重度偏头痛疗效观察

    Institute of Scientific and Technical Information of China (English)

    王志海

    2011-01-01

    目的:探讨双氯芬酸钠/盐酸利多卡因治疗中重度偏头痛的临床疗效.方法:将53例偏头痛患者分为两组:双氯芬酸钠/盐酸利多卡因(奥尔芬)治疗组,阿司匹林治疗组.于治疗前后采用视觉模拟疼痛评分(VAS)测定患者疼痛程度进行疗效比较.结果:双氯芬酸钠/盐酸利多卡因治疗组疗效优于阿司匹林治疗组(p<0.01).结论:双氯芬酸钠/盐酸利多卡因对偏头痛的镇痛程度及起效时间均优于阿司匹林.%Objective: To investigate the clinical treatment of diclofenac sodium / lidocaine hydrochloride on severe migraine. Method: 53 patients with migraine were divided into two groups: diclofenac sodium / lidocaine hydrochloride ( Ao Erfen) treatment group and aspirin treatment group. Visual Analog Pain Score (VAS ) was used to determine the pain degree of the patients before and after treatment, thus to compare their treatment efficacy. Result: Diclofenac sodium / lidocaine hydrochloride group was more effective than aspirin group ( P <0. 01 ). Conclusion: Diclofenac sodium / lidocaine hydrochloride had a better effect than aspirin in terms of pain relief and onset time.

  18. Stability-indicating HPTLC determination of ambroxol hydrochloride in bulk drug and pharmaceutical dosage form.

    Science.gov (United States)

    Jain, P S

    2010-01-01

    A simple, selective, precise, and stability-indicating high-performance thin-layer chromatographic (HPTLC) method for the analysis of ambroxol hydrochloride both as a bulk drug and in formulations was developed and validated. The method employed HPTLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. The solvent system consisted of methanol-triethylamine (4:6 v/v). The system was found to give a compact spot for ambroxol hydrochloride (R(f) value of 0.53 +/- 0.02). Densitometric analysis of ambroxol hydrochloride was carried out in the absorbance mode at 254 nm. The linear regression analysis data for the calibration plots showed good linear relationship with r(2) = 0.9966 +/- 0.0013 with respect to peak area in the concentration range 100-1000 ng/spot. The mean value +/- standard deviation of slope and intercept were 164.85 +/- 0.72 and 1168.3 +/- 8.26 with respect to peak area. The method was validated for precision, recovery, and robustness. The limits of detection and quantitation were 10 and 30 ng/spot, respectively. Ambroxol hydrochloride was subjected to oxidation and thermal degradation. The drug undergoes degradation under oxidation and heat conditions. This indicates that the drug is susceptible to oxidation and heat. Statistical analysis proves that the method is repeatable, selective, and accurate for the estimation of said drug. Stability indicating of new chemical entities is an important part for the drug development of ambroxol hydrochloride and for its estimation in plasma and other biological fluids; the novel Statistical analysis proves that the method is repeatable and selective for the analysis of ambroxol hydrochloride as bulk drug and in pharmaceutical formulations. The proposed developed HPTLC method can be applied for identification and quantitative determination of ambroxol hydrochloride in bulk drug and dosage forms. This work is to determine the purity of the drug available from the various sources by detecting

  19. High Performace Liquid Chromtographic Determination of Nicardipine Hydrochloride in Human Plasma

    Directory of Open Access Journals (Sweden)

    Y. S. R. Krishnaiah

    2004-01-01

    Full Text Available A sensitive high-performance liquid chromatographic method was developed for the estimation of nicardipine hydrochloride in human plasma. Varying amount of nicardipine hydrochloride (2.5 to 150 ng/0.5 mL and fixed quantity (100 ng/0.5 mL of nifedipine (internal standard was added to blank human plasma, and a single step extraction was carried out with ethyl acetate. The mixture was centrifuged, ethyl acetate layer separated, dried and reconstituted with 100 μL of acetonitrile. Twenty microliters of this solution was injected into a reverse phase C-18 column using a mobile phase consisting of acetonitrile: 0.02 M potassium dihydrogen phosphate (pH 4.0 in the ratio of 60:40 v/v and the eluents were monitored at 239 nm. The method was validated for its linearity, precision and accuracy. The calibration curve was linear in the range of 5-150 ng/0.5 mL of plasma and the lower detection limit was 2.5 ng/0.5 mL of plasma. The intra- and inter-day variation was found to be less than 2.5% indicating that the method is highly precise. The mean recovery of nicardipine hydrochloride from plasma samples was 89.6±2.60%. The proposed HPLC method was applied for the estimation of nicardipine hydrochloride in human plasma after oral administration of an immediate release nicardipine hydrochloride capsule (dose 30 mg to 6 adult male volunteers. There was no interference of either the drug metabolites or other plasma components with the proposed HPLC method for the estimation of nicardipine hydrochloride in human plasma. Due to its simplicity, sensitivity, high precision and accuracy, the proposed HPLC method may be used for biopharmaceutical and pharmacokinetic evaluation of nicardipine hydrochloride and its formulations in humans

  20. Human serum paraoxonase-1 (hPON1): in vitro inhibition effects of moxifloxacin hydrochloride, levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium.

    Science.gov (United States)

    Türkeş, Cüneyt; Söyüt, Hakan; Beydemir, Şükrü

    2015-01-01

    In this study, we investigated the effects of antibacterial drugs (moxifloxacin hydrochloride, levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium) on human serum paraoxonase-1 (hPON1) enzyme activity from human serum in vitro conditions. For this purpose, hPON1 enzyme was purified from human serum using simple chromatographic methods. The antibacterial drugs exhibited inhibitory effects on hPON1 at low concentrations. Ki constants were calculated to be 2.641 ± 0.040 mM, 5.525 ± 0.817 mM, 35.092 ± 1.093 mM, 252.762 ± 5.749 mM and 499.244 ± 10.149 mM, respectively. The inhibition mechanism of moxifloxacin hydrochloride was competitive, whereas levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium were noncompetitive inhibitors.

  1. HPLC Determination of Propranolol Hydrochloride,Verapamil Hydrochloride and Propafenone Hydrochloride Ilegally Mixed into Wenxin Granules%高效液相色谱法测定稳心颗粒中非法添加药物的含量

    Institute of Scientific and Technical Information of China (English)

    张士勇; 程军; 叶云

    2012-01-01

    Objective To set up a method for the determination of propranolole hydrochloride, verapamil hydrochloride and propafenone hydrochloride illegally mixed into Wenxin Granules by HPLC. Methods The HPLC method was used. The Inertsil ODS - SP C18 column (250 mm × 4. 6 mm, 5 μm) was used with the mobile phase of phosphate buffer (adding water to dissolve potassium dihydrogen phosphate 6. 8 g and sodium 1 - octanesulfonate 1. 3 g, and diluting to 1 000 mL, adjusting pH value to 3.0 with phosphoric acid ) -methanol(40: 60). The flow rate was 0.8 mL/min, the detection wavelength was set at 223 nm and the column temperature was 25 ℃. Results The calibration curve showed the good linearity for propranolole hydrochloride, verapamil hydrochloride and propafenone hydrochloride in the range of 00. 019 76-2.47 μg( r = 1) ,0. 01-2. 5 μg(r = l) and 0.009 948-2.487 μg( r = 1) respectively;the average recovery rates (n = 6) were 97. 11% , 97. 63% and 98. 88% , respectively; RSD were 1. 85% , 1. 92% and 1. 46% , respectively. Conclusion This method is accurate and reproducible, which can be used for the determination of propranolole hydrochloride, verapamil hydrochloride and propafenone hydrochloride illegally mixed into Wenxin Granules.%目的 建立检测稳心颗粒中非法添加的盐酸普萘洛尔、盐酸维拉帕米和盐酸普罗帕酮含量的高效液相色谱法.方法 采用lnertsil ODS-SP C18色谱柱(250 mm×4.6 mm,5μm),流动相为磷酸盐缓冲液(取磷酸二氢钾6.8 g,辛烷磺酸钠1.3 g,加水溶解并稀释至1 000 mL,用磷酸调节pH至3.0)-甲醇(40:60),流速为0.8 mL/min,检测波长为223 nm,柱温为25℃.结果 盐酸普萘洛尔、盐酸维拉帕米和盐酸普罗帕酮进样量的线性范围分别为0.019 76~2.47 μg(r=1),0.01~2.5μg(r=1)和0.009 948~2.487μg(r=1);平均回收率分别为97.11%,97.63%和98.88%,RSD分别为1.85%,1.92%和1.46%(n=6).结论 该方法准确、重现性好,可作为稳心颗粒中非法添加盐酸普萘洛尔、

  2. 抗HIV药物对盐酸美沙酮血药浓度影响的临床研究%Effect of anti-HIV agents on plasma concentration of methadone hydrochloride

    Institute of Scientific and Technical Information of China (English)

    李惠琴; 杨维林; 周曾全; 樊移山; 张云桂; 赵爱明; 陈庆玲; 劳云飞; 李侠; 王玉

    2011-01-01

    was determined in such patients before and after taking antiretroviral agents. Results A good linear correlation was obtained when plasma concentration of methad one hydrochloride ranged from 0.1 to 4.0 μg/ml (r =0.999 8) detected by HPLC. The plasma concentration of methadone hydrochloride decreased in all the patients on the 5th day when the patients given methadone maintance treatment received HAART at the same time. The dose of methadone hydrochloride needed to be increased in 75% of the patients. Conclusions HPLC detection of plasma concentration of methadone hydrochloride is simple, rapid and accurate. When taking antiretroviral agents in combination with methad one hydrochloride, it is the security measure to increase the dose of 20 ml every time until the withdrawal symptoms disappear in order to eliminate heroin withdrawal symptoms as soon as possible.

  3. Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry.

    Science.gov (United States)

    Abdel-Ghani, Nour T; Youssef, Ahmed F A; Awady, Mohamed A

    2005-05-01

    Two sensitive spectrophotometric and atomic absorption spectrometric procedures have been developed for determination of cinchocaine hydrochloride (Cin.Cl) in pure form and in pharmaceutical formulation. The spectrophotometric method was based on formation of an insoluble colored ion-associate between the cited drug and tetrathiocyanatocobaltate (CoTC) or hexathiocyanatochromate (CrTC) which dissolved and extracted in an organic solvent. The optimal experimental conditions for quantitative extraction such as pH, concentration of the reagents and solvent were studied. Toluene and iso-butyl alcohol proved to be the most suitable solvents for quantitative extraction of Cin-CoTC and Cin-CrTC ion-associates with maximum absorbance at 620 and 555 nm, respectively. The optimum concentration ranges, molar absorptivities, Ringbom ranges and Sandell sensitivities were also evaluated. The atomic absorption spectrometric method is based on measuring of the excess cobalt or chromium in the aqueous solution, after precipitation of the drug, at 240.7 and 357.9 nm, respectively. Linear application ranges, characteristic masses and detection limits were 57.99-361.9, 50.40 and 4.22 microg ml(-1) of Cin.Cl, in case of CoTC, while 37.99-379.9, 18.94 and 0.81 microg ml(-1) in case of CrTC.

  4. DESIGN OF GASTRO RETENTIVE DRUG DELIVERY SYSTEM OF DILTIAZEM HYDROCHLORIDE

    Directory of Open Access Journals (Sweden)

    L. K. Omray

    2014-02-01

    Full Text Available Gastro retentive drug delivery system of diltiazem hydrochloride was designed and evaluated for its effectiveness for the management of mild to moderate hypertension. Gastro retentive drug delivery system were prepared using polyvinyl alcohol and sodium carboxy methyl cellulose as the polymers and sodium bicarbonate as a gas generating agent for the reduction of floating lag time. Gastro retentive drug delivery system tablets were prepared by wet granulation method by compression in tablet compression machine. Formulations DL1, DL2, DL3, DL4 and DL5 were developed which differed in the ratio of polyvinyl alcohol and sodium carboxy methyl cellulose polymers. All the formulations were evaluated for hardness, weight variation, friability, drug content, swelling index, buoyancy studies and in vitro drug release study. In vitro drug release study was performed using United State Pharmacopoeia 23 type 2 dissolution test apparatus employing paddle stirrer at 50 r/pm. Dissolution medium was 900 ml of 0.1N hydrochloric acid at 37ºC ± 3ºC. Formulations DL3 was found to be better as compared to other formulation.

  5. Conformation and interactions of dopamine hydrochloride in solution

    Energy Technology Data Exchange (ETDEWEB)

    Callear, Samantha K.; Imberti, Silvia [ISIS Facility, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot OX11 0QX (United Kingdom); Johnston, Andrew; McLain, Sylvia E. [Biochemistry Department, University of Oxford, South Parks Road, Oxford OX1 3QU (United Kingdom)

    2015-01-07

    The aqueous solution of dopamine hydrochloride has been investigated using neutron and X-ray total scattering data together with Monte-Carlo based modelling using Empirical Potential Structure Refinement. The conformation of the protonated dopamine molecule is presented and the results compared to the conformations found in crystal structures, dopamine-complexed protein crystal structures and predicted from theoretical calculations and pharmacophoric models. It is found that protonated dopamine adopts a range of conformations in solution, highlighting the low rotational energy barrier between different conformations, with the preferred conformation being trans-perpendicular. The interactions between each of the species present (protonated dopamine molecules, water molecules, and chloride anions) have been determined and are discussed with reference to interactions observed in similar systems both in the liquid and crystalline state, and predicted from theoretical calculations. The expected strong hydrogen bonds between the strong hydrogen bond donors and acceptors are observed, together with evidence of weaker CH hydrogen bonds and π interactions also playing a significant role in determining the arrangement of adjacent molecules.

  6. FORMULATION AND EVALUATION OF EXTENDED RELEASE TABLETS OF TRAMADOL HYDROCHLORIDE

    Directory of Open Access Journals (Sweden)

    Chilvalvar Sapnil

    2013-10-01

    Full Text Available The objective of this research work was to develop extended release tablets (Twice in a day of Tramadol Hydrochloride using different Hydrophilic polymers like HPMC K15M, HPMC K4M, Metalose 60SH50, Carbopol 971P, Sodium alginate, Xanthan gum by direct compression method. Various amounts of polymers was used in the twenty four proposed formulations (F1 to F24 for the study of release rate retardant effect at 10 %, 15 %, 20 %, 25 % of total weight of tablet matrix respectively. Then the tablets were evaluated in terms of their physical parameters (weight variation, hardness, friability and thickness, drug content and in-vitro release studies. All the formulations showed compliance with pharmacopoeial standards. The in-vitro dissolution study were conducted using USP dissolution apparatus type-II (paddle method in 900 ml 0.1 N HCl for first 2 h and remaining 10 h performed in 6.8 pH phosphate buffer at 100 rpm for a total period of 12 h. Based on the dissolution data comparison with innovator product, formulation F14 was found as the best formulation. The drug release of formulation F14 followed First Order kinetic model and the mechanism was found to be non-Fickian/anomalous according to Korsmeyer-Peppas equation.

  7. FORMULATION DEVELOPMENT OF ISOXSUPRINE HYDROCHLORIDE MODIFIED RELEASE MATRIX TABLETS

    Directory of Open Access Journals (Sweden)

    Ketan Patel

    2012-01-01

    Full Text Available The objective of the present investigation was to study the effect of critical formulation parameters affecting release of isoxsuprine hydrochloride from matrix tablets using combination of polyethylene oxide (PEO and dicalcium phosphate (DCP. The powder blend consisting of drug and excipients was analyzed for angle of repose, Carr’s index and Hausner’s ratio. The tablets were prepared by direct compression method. To assess the compressional behavior of the drug-excipient blend, the tablets were analyzed for friability and crushing strength. The in vitro drug release study was carried out in distilled water. The powder blend exhibited satisfactorily flow as measured by angle of repose, Carr’s index and Hausner’s ratio. The formulation ingredients showed satisfactory tableting properties (friability <1%, crushing strength ≥ 4 kgf. The drug release was modified on addition of PEO and DCP. Addition of 5 to 25% DCP in the formulation of matrix tablets caused apparent difference in the drug dissolution in distilled water. However, the difference was insignificant as analyzed by analysis of variance (ANOVA and similarity factor ( f2. The drug release from the tablets was best explained by Weibull model. Unified Weibull model was evolved to predict drug release from the formulated batches. The findings of this investigation can be extended to industry to cut down the cost of formulation and to by-pass the existing patents employing hydrophilic matrixing agents, at least for selective drugs.

  8. Solvent screening and crystal habit of metformin hydrochloride

    Science.gov (United States)

    Benmessaoud, Ibtissem; Koutchoukali, Ouahiba; Bouhelassa, Mohamed; Nouar, Abderrahim; Veesler, Stéphane

    2016-10-01

    A multi-well setup with video-microscopy was used to study the influence of solvent on solubility, nucleation, and crystallization of an Active Pharmaceutical Ingredient (API): metformin hydrochloride (MET.HCl). Starting with 13 solvents covering a wide variety of polarity and proticity, we found 63 crystallization medium for MET.HCl solid generation: good solvents, good co-solvents and anti-solvent systems. For toxicological reasons, we limited the number of crystallization medium to 18: 3 good solvents (class 3), 3 good co-solvent systems and 12 anti-solvent systems. In order to study the influence of crystallization medium on nucleation temperature, crystal habit and polymorphism of MET.HCl, crystallization was studied by a cooling temperature method. Different crystal habits were observed by optical and scanning electron microscopies, and solid phase were characterized by X-ray powder diffraction, indicating that all the crystals correspond to the thermodynamic stable polymorphic form A of MET.HCl. Finally, the enthalpy of fusion and the melting temperature of MET.HCl were determined by DSC and confirmed the X-ray powder diffraction results.

  9. Facile colorimetric methods for the quantitative determination of tetramisole hydrochloride

    Science.gov (United States)

    Amin, A. S.; Dessouki, H. A.

    2002-10-01

    A facile, rapid and sensitive methods for the determination of tetramisole hydrochloride in pure and in dosage forms are described. The procedures are based on the formation of coloured products with the chromogenic reagents alizarin blue BB (I), alizarin red S (II), alizarin violet 3R (III) and alizarin yellow G (IV). The coloured products showed absorption maxima at 605, 468, 631 and 388 nm for I-IV, respectively. The colours obtained were stable for 24 h. The colour system obeyed Beer's law in the concentration range 1.0-36, 0.8-32, 1.2-42 and 0.8-30 μg ml -1, respectively. The results obtained showed good recoveries with relative standard deviations of 1.27, 0.96, 1.13 and 1.35%, respectively. The detection and determination limits were found to be 1