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Sample records for hydraulic resistance implications

  1. Hydraulic resistance of biofilms

    KAUST Repository

    Dreszer, C.

    2013-02-01

    Biofilms may interfere with membrane performance in at least three ways: (i) increase of the transmembrane pressure drop, (ii) increase of feed channel (feed-concentrate) pressure drop, and (iii) increase of transmembrane passage. Given the relevance of biofouling, it is surprising how few data exist about the hydraulic resistance of biofilms that may affect the transmembrane pressure drop and membrane passage. In this study, biofilms were generated in a lab scale cross flow microfiltration system at two fluxes (20 and 100Lm-2h-1) and constant cross flow (0.1ms-1). As a nutrient source, acetate was added (1.0mgL-1 acetate C) besides a control without nutrient supply. A microfiltration (MF) membrane was chosen because the MF membrane resistance is very low compared to the expected biofilm resistance and, thus, biofilm resistance can be determined accurately. Transmembrane pressure drop was monitored. As biofilm parameters, thickness, total cell number, TOC, and extracellular polymeric substances (EPS) were determined, it was demonstrated that no internal membrane fouling occurred and that the fouling layer actually consisted of a grown biofilm and was not a filter cake of accumulated bacterial cells. At 20Lm-2h-1 flux with a nutrient dosage of 1mgL-1 acetate C, the resistance after 4 days reached a value of 6×1012m-1. At 100Lm-2h-1 flux under the same conditions, the resistance was 5×1013m-1. No correlation of biofilm resistance to biofilm thickness was found; Biofilms with similar thickness could have different resistance depending on the applied flux. The cell number in biofilms was between 4×107 and 5×108 cellscm-2. At this number, bacterial cells make up less than a half percent of the overall biofilm volume and therefore did not hamper the water flow through the biofilm significantly. A flux of 100Lm-2h-1 with nutrient supply caused higher cell numbers, more biomass, and higher biofilm resistance than a flux of 20Lm-2h-1. However, the biofilm thickness

  2. Hydraulic resistance of biofilms

    KAUST Repository

    Dreszer, C.; Vrouwenvelder, Johannes S.; Paulitsch-Fuchs, Astrid H.; Zwijnenburg, Arie; Kruithof, Joop C.; Flemming, Hans Curt

    2013-01-01

    resistance is very low compared to the expected biofilm resistance and, thus, biofilm resistance can be determined accurately. Transmembrane pressure drop was monitored. As biofilm parameters, thickness, total cell number, TOC, and extracellular polymeric

  3. Estimating Hydraulic Resistance for Floodplain Mapping and Hydraulic Studies from High-Resolution Topography: Physical and Numerical Simulations

    Science.gov (United States)

    Minear, J. T.

    2017-12-01

    One of the primary unknown variables in hydraulic analyses is hydraulic resistance, values for which are typically set using broad assumptions or calibration, with very few methods available for independent and robust determination. A better understanding of hydraulic resistance would be highly useful for understanding floodplain processes, forecasting floods, advancing sediment transport and hydraulic coupling, and improving higher dimensional flood modeling (2D+), as well as correctly calculating flood discharges for floods that are not directly measured. The relationship of observed features to hydraulic resistance is difficult to objectively quantify in the field, partially because resistance occurs at a variety of scales (i.e. grain, unit and reach) and because individual resistance elements, such as trees, grass and sediment grains, are inherently difficult to measure. Similar to photogrammetric techniques, Terrestrial Laser Scanning (TLS, also known as Ground-based LiDAR) has shown great ability to rapidly collect high-resolution topographic datasets for geomorphic and hydrodynamic studies and could be used to objectively quantify the features that collectively create hydraulic resistance in the field. Because of its speed in data collection and remote sensing ability, TLS can be used both for pre-flood and post-flood studies that require relatively quick response in relatively dangerous settings. Using datasets collected from experimental flume runs and numerical simulations, as well as field studies of several rivers in California and post-flood rivers in Colorado, this study evaluates the use of high-resolution topography to estimate hydraulic resistance, particularly from grain-scale elements. Contrary to conventional practice, experimental laboratory runs with bed grain size held constant but with varying grain-scale protusion create a nearly twenty-fold variation in measured hydraulic resistance. The ideal application of this high-resolution topography

  4. Turbulent Motion of Liquids in Hydraulic Resistances with a Linear Cylindrical Slide-Valve

    Directory of Open Access Journals (Sweden)

    C. Velescu

    2015-01-01

    Full Text Available We analyze the motion of viscous and incompressible liquids in the annular space of controllable hydraulic resistances with a cylindrical linear slide-valve. This theoretical study focuses on the turbulent and steady-state motion regimes. The hydraulic resistances mentioned above are the most frequent type of hydraulic resistances used in hydraulic actuators and automation systems. To study the liquids’ motion in the controllable hydraulic resistances with a linear cylindrical slide-valve, the report proposes an original analytic method. This study can similarly be applied to any other type of hydraulic resistance. Another purpose of this study is to determine certain mathematical relationships useful to approach the theoretical functionality of hydraulic resistances with magnetic controllable fluids as incompressible fluids in the presence of a controllable magnetic field. In this report, we established general analytic equations to calculate (i velocity and pressure distributions, (ii average velocity, (iii volume flow rate of the liquid, (iv pressures difference, and (v radial clearance.

  5. Spatio-temporal evolution of apparent resistivity during coal-seam hydraulic flushing

    Science.gov (United States)

    Li, Dexing; Wang, Enyuan; Song, Dazhao; Qiu, Liming; Kong, Xiangguo

    2018-06-01

    Hydraulic flushing in gas predrainage is widely used, but the hydraulic-flushing effect is evaluated in a traditional way, by determining the desorption volume, moisture content, gas drainage rate and other conventional indices. To verify the rationality and feasibility of the multielectrode resistivity method in the evaluation of coal-seam hydraulic flushing and to research the spatio-temporal evolution of apparent resistivity during hydraulic flushing, a field test was conducted in 17# coal seam at Nuodong Mine, Guizhou. During hydraulic flushing, four stages were defined according to the variation in coal rock resistivity with time, namely, the preparation stage, the sharply decreasing stage, the rapidly increasing stage and the steady stage. The apparent resistivity of the coal rock mass is affected mainly by its own degree of fragmentation and flushing volume. A more serious rupture and a greater flushing volume yield a smaller apparent resistivity during the sharply decreasing stage and a higher resistivity during the stable stage. After three months of gas predrainage, the residual gas content and the gas pressure at different points in the expected affected area decrease below the critical value. Changes in the residual gas content and gas pressure at these points are consistent with the apparent resistivity, which validates the rationality and feasibility of the multielectrode resistivity method in evaluating coal-seam hydraulic flushing.

  6. Testing hypotheses that link wood anatomy to cavitation resistance and hydraulic conductivity in the genus Acer.

    Science.gov (United States)

    Lens, Frederic; Sperry, John S; Christman, Mairgareth A; Choat, Brendan; Rabaey, David; Jansen, Steven

    2011-05-01

    • Vulnerability to cavitation and conductive efficiency depend on xylem anatomy. We tested a large range of structure-function hypotheses, some for the first time, within a single genus to minimize phylogenetic 'noise' and maximize detection of functionally relevant variation. • This integrative study combined in-depth anatomical observations using light, scanning and transmission electron microscopy of seven Acer taxa, and compared these observations with empirical measures of xylem hydraulics. • Our results reveal a 2 MPa range in species' mean cavitation pressure (MCP). MCP was strongly correlated with intervessel pit structure (membrane thickness and porosity, chamber depth), weakly correlated with pit number per vessel, and not related to pit area per vessel. At the tissue level, there was a strong correlation between MCP and mechanical strength parameters, and some of the first evidence is provided for the functional significance of vessel grouping and thickenings on inner vessel walls. In addition, a strong trade-off was observed between xylem-specific conductivity and MCP. Vessel length and intervessel wall characteristics were implicated in this safety-efficiency trade-off. • Cavitation resistance and hydraulic conductivity in Acer appear to be controlled by a very complex interaction between tissue, vessel network and pit characteristics. © 2010 The Authors. New Phytologist © 2010 New Phytologist Trust.

  7. The effect of inlet conditions on the air side hydraulic resistance and flow maldistribution in industrial air heaters

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann-Vocke, Jonas, E-mail: jh63@waikato.ac.nz [University of Waikato, Energy Research Group, School of Science and Engineering, Private Bag 3105, Hamilton 3240 (New Zealand); Neale, James, E-mail: jamesn@waikato.ac.nz [University of Waikato, Energy Research Group, School of Science and Engineering, Private Bag 3105, Hamilton 3240 (New Zealand); Walmsley, Michael, E-mail: walmsley@waikato.ac.nz [University of Waikato, Department of Engineering, School of Science and Engineering, Private Bag 3105, Hamilton 3240 (New Zealand)

    2011-08-15

    Highlights: > Measured the effects of air heater inlet header geometry on hydraulic performance. > Measured the effects of inlet header flow maldistribution on hydraulic performance. > Inlet header flow maldistribution increases air heater system hydraulic resistance. - Abstract: Experimental system hydraulic resistance measurements on a scale air heater unit have highlighted the excessive hydraulic resistance of typical industry configurations. Both poor header inlet conditions and large header expansion angles are shown to contribute to system hydraulic resistance magnitudes 20-100% higher than suitable benchmark cases. Typical centrifugal fan system efficiencies well under 80% multiply the system resistance effects resulting in larger fan power penalties. Velocity profile measurements taken upstream and downstream of the test heat exchanger under flow maldistribution conditions provide insight into the flow maldistribution spreading caused by the heat exchanger resistance. The anisotropic resistance of the plate fin-and-tube heat exchanger is shown to result in resistance induced flow dispersion being concentrated in the axis parallel to the plate fins.

  8. Geomorphological and hydrological implications of a given hydraulic geometry relationship, beyond the power-law

    Science.gov (United States)

    Kim, JongChun; Paik, Kyungrock

    2015-04-01

    Channel geometry and hydraulic characteristics of a given river network, i.e., spatio-temporal variability of width, depth, and velocity, can be described as power functional relationships of flow discharge, named 'hydraulic geometry' (Leopold and Maddock, 1953). Many studies have focused on the implication of this power-law itself, i.e., self-similarity, and accordingly its exponents. Coefficients of the power functional relationships, on the contrary, have received little attention. They are often regarded as empirical constants, determined by 'best fitting' to the power-law without significant scientific implications. Here, we investigate and claim that power-law coefficients of hydraulic geometry relationships carry vital information of a given river system. We approach the given problem on the basis of 'basin hydraulic geometry' formulation (Stall and Fok, 1968) which decomposes power-law coefficients into more elementary constants. The linkage between classical power-law relationship (Leopold and Maddock, 1953) and the basin hydraulic geometry is provided by Paik and Kumar (2004). On the basis of this earlier study, it can be shown that coefficients and exponents of power-law hydraulic geometry are interrelated. In this sense, we argue that more elementary constants that constitute both exponents and coefficients carry important messages. In this presentation, we will demonstrate how these elementary constants vary over a wide range of catchments provided from Stall and Fok (1968) and Stall and Yang (1970). Findings of this study can provide new insights on fundamental understanding about hydraulic geometry relationships. Further, we expect that this understanding can help interpretation of hydraulic geometry relationship in the context of flood propagation through a river system as well. Keywords: Hydraulic geometry; Power-law; River network References Leopold, L. B., & Maddock, T. J. (1953). The hydraulic geometry of stream channels and some physiographic

  9. Hydraulic adjustments underlying drought resistance of Pinus halepensis.

    Science.gov (United States)

    Klein, Tamir; Cohen, Shabtai; Yakir, Dan

    2011-06-01

    Drought-induced tree mortality has increased over the last decades in forests around the globe. Our objective was to investigate under controlled conditions the hydraulic adjustments underlying the observed ability of Pinus halepensis to survive seasonal drought under semi-arid conditions. One hundred 18-month saplings were exposed in the greenhouse to 10 different drought treatments, simulating combinations of intensities (fraction of water supply relative to control) and durations (period with no water supply) for 30 weeks. Stomata closed at a leaf water potential (Ψ(l)) of -2.8 MPa, suggesting isohydric stomatal regulation. In trees under extreme drought treatments, stomatal closure reduced CO(2) uptake to -1 µmol m(-2) s(-1), indicating the development of carbon starvation. A narrow hydraulic safety margin of 0.3 MPa (from stomatal closure to 50% loss of hydraulic conductivity) was observed, indicating a strategy of maximization of CO2 uptake in trees otherwise adapted to water stress. A differential effect of drought intensity and duration was observed, and was explained by a strong dependence of the water stress effect on the ratio of transpiration to evapotranspiration T/ET and the larger partitioning to transpiration associated with larger irrigation doses. Under intense or prolonged drought, the root system became the main target for biomass accumulation, taking up to 100% of the added biomass, while the stem tissue biomass decreased, associated with up to 60% reduction in xylem volume.

  10. Numerical simulation of temperature's sensitivity of chamfer hole's resistance on hydraulic step cylinder

    International Nuclear Information System (INIS)

    Jinhua, Wang; Hanliang, Bo; Wenxiang, Zheng; Jinnong, Yang

    2003-01-01

    The control rod drive is a very important device for controlling nuclear reactor startup, operation, shut down, and power change. The ability of the control rod drive to move safely and reliably directly relates to reactor safety. The Hydraulic Control Rod Drive System (HCRDS) is a new type of control rod drive system developed by the Institute of Nuclear Energy Technology (INET) of Tsinghua University for Nuclear Heating Reactors. The HCRDS, designed using the hydrodynamic principle, has many advantages, including having the structure complete in the vessel, no possible ejection accident, short drive line, simple movable parts structure and safe shutdown during accidents. The hydraulic step cylinder is the key part for the HCRDS. In the process of reactor startup, the variation of temperature could make the water's density and viscosity change, and the force from the water flow would change accordingly. These factors could influence the performance of the hydraulic step cylinder. In this paper, the temperature sensitivity of the chamfer hole's resistance in the hydraulic step cylinder was studied with the Computational Fluid Dynamics (CFD) program CFX5.5. The results were satisfactory: the discipline of variation of the chamfer hole's resistance with the outer tube's position was the same at different temperatures, the discrepancy of the chamfer hole's resistance was small for the same position at different temperatures, the chamfer hole's resistance decreased gradually with the increase of temperature, and the decrease extent was relatively small

  11. Experimental evaluation of the hydraulic resistance of compacted bentonite/boom clay interface

    International Nuclear Information System (INIS)

    Tang, Anh-Minh; Cui, Yu-Jun; Delage, Pierre; Munoz, Juan Jorge; Li, Xiang-Ling

    2008-01-01

    In the framework of the in-situ PRACLAY Heater experiment to be performed in the HADES URF in Mol (Belgium), the feasibility of a hydraulic cut-off of the Excavation Damaged Zone (EDZ) and the Repository Components (RC) of the disposal galleries by using a horizontal seal will be examined. It has been planned to install an annular seal composed of compacted bentonite between the heated zone and the access gallery (PRACLAY seal test), so that to avoid any hydraulic shortcut towards the access gallery. According to numerical scoping calculations, heating until 80 deg C will induce a pore pressure of the order of 3.0 MPa. In order to verify the effects of this water pressure on the performance of the annular seal system and more specifically on the hydraulic resistance of the interface between the compacted bentonite and the host rock (Boom clay), laboratory percolation tests at 20 and 80 deg C were performed. The results confirm the performance of the compacted bentonite seal to avoid the hydraulic shortcut to the access gallery under the foreseen hydraulic and thermal conditions. (author)

  12. The effect of inlet conditions on the air side hydraulic resistance and flow maldistribution in industrial air heaters

    International Nuclear Information System (INIS)

    Hoffmann-Vocke, Jonas; Neale, James; Walmsley, Michael

    2011-01-01

    Highlights: → Measured the effects of air heater inlet header geometry on hydraulic performance. → Measured the effects of inlet header flow maldistribution on hydraulic performance. → Inlet header flow maldistribution increases air heater system hydraulic resistance. - Abstract: Experimental system hydraulic resistance measurements on a scale air heater unit have highlighted the excessive hydraulic resistance of typical industry configurations. Both poor header inlet conditions and large header expansion angles are shown to contribute to system hydraulic resistance magnitudes 20-100% higher than suitable benchmark cases. Typical centrifugal fan system efficiencies well under 80% multiply the system resistance effects resulting in larger fan power penalties. Velocity profile measurements taken upstream and downstream of the test heat exchanger under flow maldistribution conditions provide insight into the flow maldistribution spreading caused by the heat exchanger resistance. The anisotropic resistance of the plate fin-and-tube heat exchanger is shown to result in resistance induced flow dispersion being concentrated in the axis parallel to the plate fins.

  13. Economic implications of resistance to antimalarial drugs.

    Science.gov (United States)

    Phillips, M; Phillips-Howard, P A

    1996-09-01

    The widespread evolution of drug resistance in malarial parasites has seriously hampered efforts to control this debilitating disease. Chloroquine, the mainstay of malaria treatment for many decades, is now proving largely ineffective in many parts of the world, particularly against the most severe form of malaria--falciparum. Alternative drugs have been developed, but they are frequently less safe and are all between 50 and 700% more expensive than chloroquine. Choice of drug clearly has important budgetary implications and national malaria control programmes need to weigh up the costs and benefits in deciding whether to change to more effective but more expensive drugs. The growth in drug resistance also has implications for the choice of diagnostic tool. Clinical diagnosis of malaria is relatively cheap, but less specific than some technological approaches. As more expensive drugs are employed, the cost of wasted treatment on suspected cases who do not in fact have malaria rises and the more worthwhile it becomes to invest in more specific diagnostic techniques. This paper presents an economic framework for analysing the various malaria drug and diagnostic tool options available. It discusses the nature of the key factors that need to be considered when making choices of malaria treatment (including treatment costs, drug resistance, the costs of treatment failure and compliance) and diagnosis (including diagnosis cost and accuracy, and the often overlooked costs associated with delayed treatment), and uses some simple equations to illustrate the impact of these on the relative cost effectiveness of the alternatives being considered. On the basis of some simplifying assumptions and illustrative calculations, it appears that in many countries more effective drugs and more specific and rapid diagnostic approaches will be worth adopting even although they imply additional expense.

  14. Influence of deep cryogenic treatment on structure and wear resistance of materials of hydraulic breaker chisels

    Science.gov (United States)

    Bolobov, V. I.; BinhLe, Thanh

    2018-03-01

    It is shown that shallow cryogenic treatment at -75°C (SCT) of the materials of hydraulic breaker chisels - P20, 1080 and D2 steels leads to a decrease (44 ÷ 82%) in the amount of retained austenite and an increase (26 ÷ 99%) in the amount of carbides in the structure of hardened steel, which is accompanied by an increase in its hardness (1.4 ÷ 2.1%) and abrasive wear resistance (10 ÷ 31%) with a simultaneous decrease in impact toughness (19 ÷ 24%). Deep cryogenic treatment at -196°C (DCT) and subsequent low-temperature tempering of D2 steel leads to a significant increase in its wear resistance (98%) and impact toughness (32%).

  15. Estimation of hydraulic conductivity on clay content in soil determined from resistivity data

    Energy Technology Data Exchange (ETDEWEB)

    Shevnin, Vladimir; Delgado-Rodriguez, Omar; Mousatov, Aleksandr [Mexican Petroleum Institute, Mexico, D.F. (Mexico); Ryjov, Albert [Moscow State Geological Prospecting Academy, Geophysical Faculty, Moscow (Russian Federation)

    2006-07-15

    The influence of clay content in sandy and clayey soils on hydraulic conductivity (filtration coefficient) is considered. A review of published experimental data on the relationship of hydraulic conductivity with soil lithology and grain size, as dependent on clay content is presented. Theoretical calculations include clay content. Experimental and calculated data agree, and several approximation formulas for filtration coefficient vs clay content are presented. Clay content in soil is estimated from electric resistivity data obtained from 2D VES interpretation. A two-step method is proposed, the first step including clay content calculating from soil resistivity and groundwater salinity, and the second step including filtration coefficient estimating from clay content. Two applications are presented. [Spanish] El contenido de arcilla en suelos areno-arcillosos influye sobre la permeabilidad hidraulica (coeficiente de filtracion). Se presenta una revision de datos experimentales publicados que relacionan el coeficiente de filtracion con el tipo litologico del suelo y el tamano de las particulas. A partir de calculos teoricos, se modifican las conocidas formulas que relacionan el coeficiente de filtracion con el contenido de arcilla. Se estima el contenido de arcilla a partir de los datos interpretados por el metodo SEV, y se propone un procedimiento para la estimacion del coeficiente de filtracion: (a) calculo del contenido de arcilla a partir de la resistividad del suelo y de la salinidad del agua subterranea, (b) estimacion del coeficiente de filtracion a partir del contenido de arcilla. Se presentan algunos ejemplos de la aplicacion de esta metodologia.

  16. Ion-mediated changes of xylem hydraulic resistance in planta: fact or fiction?

    Science.gov (United States)

    van Ieperen, Wim

    2007-04-01

    Although xylem provides an efficient transport pathway for water in plants, the hydraulic conductivity of xylem (K(h)) can still influence plant water status. For decades, the K(h) of functional xylem has been assumed to be constant in the short term because xylem consists of a network of dead interconnected capillary elements (conduits). Recent research has shown that K(h) can change in response to the cation content of the xylem fluid. Volume changes of pectin gel in nanometer-sized pores at inter-conduit connections are hypothesized to be the cause, and implications for xylem transport in planta are suggested. However, it seems too early to be conclusive about this phenomenon because the phenomenon has not been measured in planta with xylem fluids that realistically mimic natural xylem sap and the applied methods used to measure ion-mediated changes in K(h) have drawbacks.

  17. Thermal-hydraulic development a small, simplified, proliferation-resistant reactor

    International Nuclear Information System (INIS)

    Farmer, M. T.; Hill, D. J.; Sienicki, J. J.; Spencer, B. W.; Wade, D. C.

    1999-01-01

    This paper addresses thermal-hydraulics related criteria and preliminary concepts for a small (300 MWt), proliferation-resistant, liquid-metal-cooled reactor system. A main objective is to assess what extent of simplification is achievable in the concepts with the primary purpose of regaining economic competitiveness. The approach investigated features lead-bismuth eutectic (LBE) and a low power density core for ultra-long core lifetime (goal 15 years) with cartridge core replacement at end of life. This potentially introduces extensive simplifications resulting in capital cost and operating cost savings including: (1) compact, modular, pool-type configuration for factory fabrication, (2) 100+% natural circulation heat transport with the possibility of eliminating the main coolant pumps, (3) steam generator modules immersed directly in the primary coolant pool for elimination of the intermediate heat transport system, and (4) elimination of on-site fuel handling and storage provisions including rotating plug. Stage 1 natural circulation model and results are presented. Results suggest that 100+% natural circulation heat transport is readily achievable using LBE coolant and the long-life cartridge core approach; moreover, it is achievable in a compact pool configuration considerably smaller than PRISM A (for overland transportability) and with peak cladding temperature within the existing database range for ferritic steel with oxide layer surface passivation. Stage 2 analysis follows iteration with core designers. Other thermal hydraulic investigations are underway addressing passive, auxiliary heat removal by air cooling of the reactor vessel and the effects of steam generator tube rupture

  18. Flow resistance of orifices and spacers of BWR thermal-hydraulic and neutronic coupling loop

    International Nuclear Information System (INIS)

    Iguchi, Tadashi; Asaka, Hideaki; Nakamura, Hideo

    2002-03-01

    Authors are performing THYNC experiments to study thermal-hydraulic instability under neutronic and thermal-hydraulic coupling. In THYNC experiments, the orifices are installed at the exit of the test section and the spacers are installed in the test section, in order to properly simulate in-core thermal-hydraulics in the reactor core. It is necessary to know the flow resistance of the orifices and spacers for the analysis of THYNC experimental results. Consequently, authors measured the flow resistance of orifice and spacer under single-phase and two-phase flows. Using the experimental results, authors investigated the dependency of the flow resistances on the parameters, such as pressure, mass flux, an geometries. Furthermore, authors investigated the applicability of the basic two-phase flow models, for example the separate flow model, to the two-phase flow multiplier. As the result of the investigation on the single-phase flow experiment, it was found (1) that the effects of pressure and mass flux flow resistance are described by a function of Reynolds number, and (2) that flow resistances of the orifice and the spacer are calculated with the previous prediction methods. However, it was necessary to introduce an empirical coefficient, since it was difficult to predict accurately the flow resistance only with the previous prediction method due to the complicated geometry dependency, for example a flow area blockage ratio. On the other hand, according to the investigation on two-phase flow experiment, the followings were found. (1) Relation between the two-phase flow multiplier and the quality is regarded to be linear under pressure of 2MPa - 7MPa. The relation is dependent on pressure and geometry, and is little dependent on mass flux. (2) Relation between the two-phase flow multiplier and void fraction is little dependent on pressure, mass flux, and geometry under pressure of 0.2MPa - 7MPa and void fraction less than 0.6. The relation is less dependent on

  19. Averaging hydraulic head, pressure head, and gravitational head in subsurface hydrology, and implications for averaged fluxes, and hydraulic conductivity

    Directory of Open Access Journals (Sweden)

    G. H. de Rooij

    2009-07-01

    Full Text Available Current theories for water flow in porous media are valid for scales much smaller than those at which problem of public interest manifest themselves. This provides a drive for upscaled flow equations with their associated upscaled parameters. Upscaling is often achieved through volume averaging, but the solution to the resulting closure problem imposes severe restrictions to the flow conditions that limit the practical applicability. Here, the derivation of a closed expression of the effective hydraulic conductivity is forfeited to circumvent the closure problem. Thus, more limited but practical results can be derived. At the Representative Elementary Volume scale and larger scales, the gravitational potential and fluid pressure are treated as additive potentials. The necessary requirement that the superposition be maintained across scales is combined with conservation of energy during volume integration to establish consistent upscaling equations for the various heads. The power of these upscaling equations is demonstrated by the derivation of upscaled water content-matric head relationships and the resolution of an apparent paradox reported in the literature that is shown to have arisen from a violation of the superposition principle. Applying the upscaling procedure to Darcy's Law leads to the general definition of an upscaled hydraulic conductivity. By examining this definition in detail for porous media with different degrees of heterogeneity, a series of criteria is derived that must be satisfied for Darcy's Law to remain valid at a larger scale.

  20. Wood density and anatomy of three Eucalyptus species: implications for hydraulic conductivity

    International Nuclear Information System (INIS)

    Barotto, A.J.; Monteoliva, S.; Gyenge, J.; Martínez-Meier, A.; Moreno, K.; Tesón, N.; Fernández, M.E.

    2017-01-01

    Aim of the study: To characterize wood anatomical traits of three Eucalyptus species that differ in wood density and ecological requirements, and to examine the relationships between some anatomical features, wood density, and theoretical xylem hydraulic conductivity (Ks). Area of study: We analyzed 86 trees from three sites of Argentina (Entre Ríos and Buenos Aires Provinces). Methods: The sampled trees were Eucalyptus globulus, E. grandis and E. viminalis ranging from 11 to 15 years old. One stem disc was cut from each tree to determine wood density and identify quantitative anatomical features of vessels and fibers. Vessel composition (S, size - to-number ratio, a measure of vessel size distribution) and lumen fraction (F, the total sapwood area available for water transport) were estimated. Results: E. grandis, the species with the highest growth rates, presented the highest theoretical Ks. This was associated with anatomical features such as a high density of wide vessels resulting in high F. On the other hand, E. viminalis, the species with the lowest growth rates and highest resistance to environmental stress, showed lower Ks as a result of a low density of wide vessels. These two species differed not only greatly in wood density but also in fiber characteristics. In the case of E. globulus, vessels were relatively narrow, which resulted in the lowest theoretical Ks, fibers were small, and wood density intermediate. Research highlights: F had greater influence on Ks than S. The anatomical characteristics and wood density could only partly explain the differential growth or resistance to stress of the studied species.

  1. Wood density and anatomy of three Eucalyptus species: implications for hydraulic conductivity

    Directory of Open Access Journals (Sweden)

    Antonio J. Barotto

    2017-05-01

    Full Text Available Aim of the study: To characterize wood anatomical traits of three Eucalyptus species that differ in wood density and ecological requirements, and to examine the relationships between some anatomical features, wood density, and theoretical xylem hydraulic conductivity (Ks. Area of study: We analyzed 86 trees from three sites of Argentina (Entre Ríos and Buenos Aires Provinces. Methods: The sampled trees were Eucalyptus globulus, E. grandis and E. viminalis ranging from 11 to 15 years old. One stem disc was cut from each tree to determine wood density and identify quantitative anatomical features of vessels and fibers. Vessel composition (S, size - to-number ratio, a measure of vessel size distribution and lumen fraction (F, the total sapwood area available for water transport were estimated. Results: E. grandis, the species with the highest growth rates, presented the highest theoretical Ks. This was associated with anatomical features such as a high density of wide vessels resulting in high F. On the other hand, E. viminalis, the species with the lowest growth rates and highest resistance to environmental stress, showed lower Ks as a result of a low density of wide vessels. These two species differed not only greatly in wood density but also in fiber characteristics. In the case of E. globulus, vessels were relatively narrow, which resulted in the lowest theoretical Ks, fibers were small, and wood density intermediate. Research highlights: F had greater influence on Ks than S. The anatomical characteristics and wood density could only partly explain the differential growth or resistance to stress of the studied species.

  2. Wood density and anatomy of three Eucalyptus species: implications for hydraulic conductivity

    Energy Technology Data Exchange (ETDEWEB)

    Barotto, A.J.; Monteoliva, S.; Gyenge, J.; Martínez-Meier, A.; Moreno, K.; Tesón, N.; Fernández, M.E.

    2017-11-01

    Aim of the study: To characterize wood anatomical traits of three Eucalyptus species that differ in wood density and ecological requirements, and to examine the relationships between some anatomical features, wood density, and theoretical xylem hydraulic conductivity (Ks). Area of study: We analyzed 86 trees from three sites of Argentina (Entre Ríos and Buenos Aires Provinces). Methods: The sampled trees were Eucalyptus globulus, E. grandis and E. viminalis ranging from 11 to 15 years old. One stem disc was cut from each tree to determine wood density and identify quantitative anatomical features of vessels and fibers. Vessel composition (S, size - to-number ratio, a measure of vessel size distribution) and lumen fraction (F, the total sapwood area available for water transport) were estimated. Results: E. grandis, the species with the highest growth rates, presented the highest theoretical Ks. This was associated with anatomical features such as a high density of wide vessels resulting in high F. On the other hand, E. viminalis, the species with the lowest growth rates and highest resistance to environmental stress, showed lower Ks as a result of a low density of wide vessels. These two species differed not only greatly in wood density but also in fiber characteristics. In the case of E. globulus, vessels were relatively narrow, which resulted in the lowest theoretical Ks, fibers were small, and wood density intermediate. Research highlights: F had greater influence on Ks than S. The anatomical characteristics and wood density could only partly explain the differential growth or resistance to stress of the studied species.

  3. Can resistive breathing injure the lung? Implications for COPD exacerbations

    Directory of Open Access Journals (Sweden)

    Vassilakopoulos T

    2016-09-01

    Full Text Available Theodoros Vassilakopoulos, Dimitrios Toumpanakis Pulmonary and Critical Care Medicine, Medical School, National and Kapodistrian University of Athens, Greece Abstract: In obstructive lung diseases, airway inflammation leads to bronchospasm and thus resistive breathing, especially during exacerbations. This commentary discusses experimental evidence that resistive breathing per se (the mechanical stimulus in the absence of underlying airway inflammation leads to lung injury and inflammation (mechanotransduction. The potential implications of resistive breathing-induced mechanotrasduction in COPD exacerbations are presented along with the available clinical evidence. Keywords: resistive breathing, COPD, mechanotransduction, bronchoconstriction, inflammation

  4. Monitoring of Non-Ferrous Wear Debris in Hydraulic Oil by Detecting the Equivalent Resistance of Inductive Sensors

    Directory of Open Access Journals (Sweden)

    Lin Zeng

    2018-03-01

    Full Text Available Wear debris in hydraulic oil contains important information on the operation of equipment, which is important for condition monitoring and fault diagnosis in mechanical equipment. A micro inductive sensor based on the inductive coulter principle is presented in this work. It consists of a straight micro-channel and a 3-D solenoid coil wound on the micro-channel. Instead of detecting the inductance change of the inductive sensor, the equivalent resistance change of the inductive sensor is detected for non-ferrous particle (copper particle monitoring. The simulation results show that the resistance change rate caused by the presence of copper particles is greater than the inductance change rate. Copper particles with sizes ranging from 48 μm to 150 μm were used in the experiment, and the experimental results are in good agreement with the simulation results. By detecting the inductive change of the micro inductive sensor, the detection limit of the copper particles only reaches 70 μm. However, the detection limit can be improved to 48 μm by detecting the equivalent resistance of the inductive sensor. The equivalent resistance method was demonstrated to have a higher detection accuracy than conventional inductive detection methods for non-ferrous particle detection in hydraulic oil.

  5. Resistência hidráulica da crosta formada em solos submetidos a chuvas simuladas Crust hydraulic resistance in soils under simulated rain

    Directory of Open Access Journals (Sweden)

    Viviane dos Santos Brandão

    2006-02-01

    micromorphometry, the crust hydraulic conductivity and hydraulic resistance were calculated. The crust hydraulic resistance increased with the kinetic energy of the rain (especially for Red-Yellow Ultisol and Red Ultisol up to a maximum value. The following decrease of crust hydraulic resistance was attributed to the crust erosion caused by increasing runoff. Multiple regression analysis determined the relationship of crust hydraulic resistance with the rainfall kinetic energy as well as the chemical and physical characteristics of each soil. The hydraulic resistance appeared to be an appropriate variable to be used in models of water infiltration in the soil to describe the crust influence on this process.

  6. Modeling Thermal Pressurization Around Shallow Dikes Using Temperature-Dependent Hydraulic Properties: Implications for Deformation Around Intrusions

    Science.gov (United States)

    Townsend, Meredith R.

    2018-01-01

    Pressurization and flow of groundwater around igneous intrusions depend in part on the hydraulic diffusivity of the host rocks and processes that enhance diffusivity, such as fracturing, or decrease diffusivity, such as mineral precipitation during chemical alteration. Characterizing and quantifying the coupled effects of alteration, pore pressurization, and deformation have significant implications for deformation around intrusions, geothermal energy, contact metamorphism, and heat transfer at mid-ocean ridges. Fractures around dikes at Ship Rock, New Mexico, indicate that pore pressures in the host rocks exceeded hydrostatic conditions by at least 15 MPa following dike emplacement. Hydraulic measurements and petrographic analysis indicate that mineral precipitation clogged the pores of the host rock, reducing porosity from 0.25 to reducing permeability by 5 orders of magnitude. Field data from Ship Rock are used to motivate and constrain numerical models for thermal pore fluid pressurization adjacent to a meter-scale dike, using temperature-dependent hydraulic properties in the host rock as a proxy for porosity loss by mineral precipitation during chemical alteration. Reduction in permeability by chemical alteration has a negligible effect on pressurization. However, reduction in porosity by mineral precipitation increases fluid pressure by constricting pore volume and is identified as a potentially significant source of pressure. A scaling relationship is derived to determine when porosity loss becomes important; if permeability is low enough, pressurization by porosity loss outweighs pressurization by thermal expansion of fluids.

  7. Effective hydraulic resistance of a nozzle generating hybrid-synthetic jet in an electrodynamic actuator - Part II: Analysis and correlations

    Czech Academy of Sciences Publication Activity Database

    Tesař, Václav; Kordík, Jozef

    Roč. 199, September (2013), s. 391-400 ISSN 0924-4247 R&D Projects: GA TA ČR TA02020795; GA ČR(CZ) GCP101/11/J019; GA ČR GPP101/12/P556 Institutional research plan: CEZ:AV0Z20760514 Institutional support: RVO:61388998 Keywords : nozzle * periodic jet * hydraulic resistance Subject RIV: BK - Fluid Dynamics Impact factor: 1.943, year: 2013 http://dx.doi.org/10.1016/j.sna.2013.01.003

  8. Ion-mediated changes of xylem hydraulic resistance in planta: fact or fiction?

    NARCIS (Netherlands)

    Ieperen, van W.

    2007-01-01

    Although xylem provides an efficient transport pathway for water in plants, the hydraulic conductivity of xylem (Kh) can still influence plant water status. For decades, the Kh of functional xylem has been assumed to be constant in the short term because xylem consists of a network of dead

  9. Wood density and anatomy of three Eucalyptus species: implications for hydraulic conductivity

    OpenAIRE

    Barotto, Antonio J.; Monteoliva, Silvia; Gyenge, Javier; Martínez-Meier, Alejandro; Moreno, Karen; Tesón, Natalia; Fernández, María Elena

    2017-01-01

    Aim of the study: To characterize wood anatomical traits of three Eucalyptus species that differ in wood density and ecological requirements, and to examine the relationships between some anatomical features, wood density, and theoretical xylem hydraulic conductivity (Ks).Area of study: We analyzed 86 trees from three sites of Argentina (Entre Ríos and Buenos Aires Provinces).Methods: The sampled trees were Eucalyptus globulus, E. grandis and E. viminalis ranging from 11 to 15 years old. One ...

  10. Wood density and anatomy of three Eucalyptus species: implications for hydraulic conductivity

    OpenAIRE

    Antonio J. Barotto; Silvia Monteoliva; Javier Gyenge; Alejandro Martínez-Meier; Karen Moreno; Natalia Tesón; María Elena Fernández

    2017-01-01

    Aim of the study: To characterize wood anatomical traits of three Eucalyptus species that differ in wood density and ecological requirements, and to examine the relationships between some anatomical features, wood density, and theoretical xylem hydraulic conductivity (Ks). Area of study: We analyzed 86 trees from three sites of Argentina (Entre Ríos and Buenos Aires Provinces). Methods: The sampled trees were Eucalyptus globulus, E. grandis and E. viminalis ranging from 11 to 15 years...

  11. The influence of molecular layers of amines on the hydraulic resistance of piping systems and power plant equipment

    Energy Technology Data Exchange (ETDEWEB)

    Ryzhenkov, Viacheslav A.; Ryzhenkov, Artem V. [Moscow Power Engineering Institute / Technical Univ. (Russian Federation). Dept. of Industrial Heat and Power Systems; Petrova, Tamara I. [Moscow Power Engineering Institute / Technical Univ. (Russian Federation). Water and Fuel Technology Dept.

    2012-07-15

    The current state of pipeline systems and power equipment has a high accident rate due to intense corrosion, the accumulation of deposits on heat and in-line transfer surfaces, and high hydraulic resistance. Analysis and synthesis of published results shows that the solution to improving the efficiency of pipeline systems and power equipment can be approached from two directions: (i) the impact on the properties of transported media and (ii) changes in the properties of functional surfaces of pipelines and equipment. Improving the ''quality'' of the technological agents involves very substantial capital and operating costs, so the most promising way is to modify the surface properties. Studies conducted at the National Research University MPEI showed that these problems are solved more effectively by means of molecular layers of adsorbed amines on the functional surfaces of pipes and equipment. When present in a certain way with the optimal number of molecular amine layers, these significantly alter the surface properties of conventional structural materials, which leads to very substantial improvement in the hydrodynamic characteristics: reduction of the hydraulic resistance of pipelines and equipment (up to 40 %), almost complete stoppage of corrosion processes (up to 7 times), and a multiple (up to 10-fold) reduction in the rate of deposit accumulation. The method of adsorption of molecular amine layers and the equipment for its implementation developed on the basis of this research will not only reduce flow resistance, but will also significantly improve the operating efficiency of pipeline systems and power equipment generally. (orig.)

  12. Induction of Hyperalgesia in Pigs through Blocking Low Hydraulic Resistance Channels and Reduction of the Resistance through Acupuncture: A Mechanism of Action of Acupuncture

    Directory of Open Access Journals (Sweden)

    Wei-Bo Zhang

    2013-01-01

    Full Text Available According to the classic theory of Chinese medicine, pain is due to the blockage in meridian channels, and acupuncture was invented to treat pain by “dredging” the channels. To test the theory, a hyperalgesia model was made by injecting hydrogel into low hydraulic resistance channel (LHRC in 12 anaesthetized minipigs. Tail-flick threshold and ear-flick threshold were measured using a thermal radiation dolorimeter, and relative flick threshold (RFT was calculated. Hydraulic resistance (HR was measured with a biological HR measuring instrument on low HR points on LHRC and on control points with higher HR located outside LHRC; readings were recorded before, during, and after acupuncture treatment. RFT decreased after blocking the LRHC and was still significantly decreased 2 days and 4 days afterwards. No significant changes occurred when injecting saline into the same points or injecting gel into points outside the channel. Subsequent acupuncture reduced HR on LRHC along meridians but had no significant effect on sites with higher HR located outside LHRC. One of the mechanisms of action of acupuncture treatment for chronic pain may be that acupuncture affects peripheral tissue by reducing the HR in LHRC along meridians, improving the flow of interstitial fluid and removing algogenic substances and thereby relieving pain.

  13. Removal of antibiotics and antibiotic resistance genes from domestic sewage by constructed wetlands: Optimization of wetland substrates and hydraulic loading.

    Science.gov (United States)

    Chen, Jun; Wei, Xiao-Dong; Liu, You-Sheng; Ying, Guang-Guo; Liu, Shuang-Shuang; He, Liang-Ying; Su, Hao-Chang; Hu, Li-Xin; Chen, Fan-Rong; Yang, Yong-Qiang

    2016-09-15

    This study aimed to assess removal potential of antibiotics and antibiotic resistance genes (ARGs) in raw domestic wastewater by various mesocosm-scale horizontal subsurface-flow constructed wetlands (CWs) planted Cyperus alternifolius L. with different design parameters. Twelve CWs with three hydraulic loading rates (HLR 10, 20 and 30cm/day) and four substrates (oyster shell, zeolite, medical stone and ceramic) were set up in order to select the best optimized wetland. The result showed that 7 target antibiotics compounds including erythromycin-H2O, lincomycin, monensin, ofloxacin, sulfamerazine, sulfamethazine and novobiocin were detected, and all selected 18 genes (three sulfonamide resistance genes (sul1, sul2 and sul3), four tetracycline resistance genes (tetG, tetM, tetO and tetX), two macrolide resistance genes (ermB and ermC), three quinolone resistance genes (qnrB, qnrD and qnrS) and four chloramphenicol resistance genes (cmlA, fexA, fexB and floR)) and two integrase genes (int1 and int2) were positively detected in the domestic wastewaters. The aqueous removal rates of the total antibiotics ranged from17.9 to 98.5%, while those for the total ARGs varied between 50.0 and 85.8% by the mesocosm-scale CWs. After considering their aqueous removal rates in combination with their mass removals, the CW with zeolite as the substrate and HLR of 20cm/day was selected as the best choice. Combined chemical and biological analyses indicate that both microbial degradation and physical sorption processes were responsible for the fate of antibiotics and ARGs in the wetlands. The findings from this study suggest constructed wetlands could be a promising technology for the removal of emerging contaminants such as antibiotics and ARGs in domestic wastewater. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Lead-free, bronze-based surface layers for wear resistance in axial piston hydraulic pumps

    Energy Technology Data Exchange (ETDEWEB)

    Vetterick, Gregory Alan [Iowa State Univ., Ames, IA (United States)

    2010-01-01

    Concerns regarding the safety of lead have provided sufficient motivation to develop substitute materials for the surface layer on a thrust bearing type component known as a valve plate in axial piston hydraulic pumps that consists of 10% tin, 10% lead, and remainder cooper (in wt. %). A recently developed replacement material, a Cu-10Sn-3Bi (wt.%) P/M bronze, was found to be unsuitable as valve plate surface layer, requiring the development of a new alloy. A comparison of the Cu-1-Sn-10Pb and Cu-10Sn-3Bi powder metal valve plates showed that the differences in wear behavior between the two alloys arose due to the soft phase bismuth in the alloy that is known to cause both solid and liquid metal embrittlement of copper alloys.

  15. Relationship of visfatin level to pancreatic endocrine hormone level, HOMA-IR index, and HOMA β-cell index in overweight women who performed hydraulic resistance exercise

    OpenAIRE

    Ha, Chang Ho; Swearingin, Brenda; Jeon, Yong Kyun

    2015-01-01

    [Purpose] This study aimed to examine the correlation of visfatin level to pancreatic endocrine hormone level, homeostasis model assessment of insulin resistance (HOMA-IR) index, and HOMA β-cell index in hydraulic resistance exercise. Furthermore, it investigated the relationship between visfatin level and other variables affected by exercise in overweight women. [Subjects and Methods] The exercise group trained for 12 weeks, 70 minutes/day, 5 days/week. Visfatin level, pancreatic endocrine h...

  16. Implications of vegetation hydraulic capacitance as an indicator of water stress and drought recovery

    Science.gov (United States)

    Matheny, A. M.; Bohrer, G.

    2017-12-01

    Above-ground water storage in vegetation plays an integral role in the avoidance of hydraulic impairment to transpiration. New high temporal resolution measurements of dynamic changes in tree hydraulic capacitance are facilitating insights into vegetation water use strategies. Diurnal withdrawal from water storage in leaves, branches, stems, and roots significantly impacts sap flow, stomatal conductance, and transpiration. The ability to store and use water varies based on soil- and root-water availability, tree size, wood vessel anatomy and density, and stomatal response strategy (i.e. isohydricity). We present results from a three-year long study of stem capacitance dynamics in five species in a mixed deciduous forest in Michigan. The site receives 800mm of rainfall annually, but water potential in the well-drained sandy soil nears the permanent wilting point several times annually. We demonstrate radical differences in stored water use between drought tolerant and intolerant species. Red maple, a drought intolerant, isohydric species, showed a strong dependence on stem capacitance for transpiration during both wet and dry periods. Red oak, a more drought hearty, deep rooted, anisohydric species, was much less reliant on withdrawal from water storage during all conditions. During well-watered conditions, withdrawal from storage by red maple was 10 kg day-1, yet storage withdrawal from similarly sized red oaks was 1 kg day-1. Red oaks only drew strongly upon stored water during the driest extremes. Metrics of hydration status derived from capacitance provide a means to explore drought response and recovery. Declines in consecutive days' maximum capacitance indicate an inability to restore lost water and can be used to mark the onset of water stress. Drought recovery can be quantified as the time required for stem water content to return to pre-drought volumes. Capacitance withdrawal and depletion exhibit a clear threshold response to declining soil water

  17. Swath-altimetry measurements of the main stem Amazon River: measurement errors and hydraulic implications

    Science.gov (United States)

    Wilson, M. D.; Durand, M.; Jung, H. C.; Alsdorf, D.

    2015-04-01

    The Surface Water and Ocean Topography (SWOT) mission, scheduled for launch in 2020, will provide a step-change improvement in the measurement of terrestrial surface-water storage and dynamics. In particular, it will provide the first, routine two-dimensional measurements of water-surface elevations. In this paper, we aimed to (i) characterise and illustrate in two dimensions the errors which may be found in SWOT swath measurements of terrestrial surface water, (ii) simulate the spatio-temporal sampling scheme of SWOT for the Amazon, and (iii) assess the impact of each of these on estimates of water-surface slope and river discharge which may be obtained from SWOT imagery. We based our analysis on a virtual mission for a ~260 km reach of the central Amazon (Solimões) River, using a hydraulic model to provide water-surface elevations according to SWOT spatio-temporal sampling to which errors were added based on a two-dimensional height error spectrum derived from the SWOT design requirements. We thereby obtained water-surface elevation measurements for the Amazon main stem as may be observed by SWOT. Using these measurements, we derived estimates of river slope and discharge and compared them to those obtained directly from the hydraulic model. We found that cross-channel and along-reach averaging of SWOT measurements using reach lengths greater than 4 km for the Solimões and 7.5 km for Purus reduced the effect of systematic height errors, enabling discharge to be reproduced accurately from the water height, assuming known bathymetry and friction. Using cross-sectional averaging and 20 km reach lengths, results show Nash-Sutcliffe model efficiency values of 0.99 for the Solimões and 0.88 for the Purus, with 2.6 and 19.1 % average overall error in discharge, respectively. We extend the results to other rivers worldwide and infer that SWOT-derived discharge estimates may be more accurate for rivers with larger channel widths (permitting a greater level of cross

  18. Characterization of hydraulic fracturing flowback water in Colorado: implications for water treatment.

    Science.gov (United States)

    Lester, Yaal; Ferrer, Imma; Thurman, E Michael; Sitterley, Kurban A; Korak, Julie A; Aiken, George; Linden, Karl G

    2015-04-15

    A suite of analytical tools was applied to thoroughly analyze the chemical composition of an oil/gas well flowback water from the Denver-Julesburg (DJ) basin in Colorado, and the water quality data was translated to propose effective treatment solutions tailored to specific reuse goals. Analysis included bulk quality parameters, trace organic and inorganic constituents, and organic matter characterization. The flowback sample contained salts (TDS=22,500 mg/L), metals (e.g., iron at 81.4 mg/L) and high concentration of dissolved organic matter (DOC=590 mgC/L). The organic matter comprised fracturing fluid additives such as surfactants (e.g., linear alkyl ethoxylates) and high levels of acetic acid (an additives' degradation product), indicating the anthropogenic impact on this wastewater. Based on the water quality results and preliminary treatability tests, the removal of suspended solids and iron by aeration/precipitation (and/or filtration) followed by disinfection was identified as appropriate for flowback recycling in future fracturing operations. In addition to these treatments, a biological treatment (to remove dissolved organic matter) followed by reverse osmosis desalination was determined to be necessary to attain water quality standards appropriate for other water reuse options (e.g., crop irrigation). The study provides a framework for evaluating site-specific hydraulic fracturing wastewaters, proposing a suite of analytical methods for characterization, and a process for guiding the choice of a tailored treatment approach. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Ecological and soil hydraulic implications of microbial responses to stress - A modeling analysis

    Science.gov (United States)

    Brangarí, Albert C.; Fernàndez-Garcia, Daniel; Sanchez-Vila, Xavier; Manzoni, Stefano

    2018-06-01

    A better understanding of microbial dynamics in porous media may lead to improvements in the design and management of a number of technological applications, ranging from the degradation of contaminants to the optimization of agricultural systems. To this aim, there is a recognized need for predicting the proliferation of soil microbial biomass (often organized in biofilms) under different environments and stresses. We present a general multi-compartment model to account for physiological responses that have been extensively reported in the literature. The model is used as an explorative tool to elucidate the ecological and soil hydraulic consequences of microbial responses, including the production of extracellular polymeric substances (EPS), the induction of cells into dormancy, and the allocation and reuse of resources between biofilm compartments. The mechanistic model is equipped with indicators allowing the microorganisms to monitor environmental and biological factors and react according to the current stress pressures. The feedbacks of biofilm accumulation on the soil water retention are also described. Model runs simulating different degrees of substrate and water shortage show that adaptive responses to the intensity and type of stress provide a clear benefit to microbial colonies. Results also demonstrate that the model may effectively predict qualitative patterns in microbial dynamics supported by empirical evidence, thereby improving our understanding of the effects of pore-scale physiological mechanisms on the soil macroscale phenomena.

  20. Wood anatomy reveals high theoretical hydraulic conductivity and low resistance to vessel implosion in a Cretaceous fossil forest from northern Mexico.

    Science.gov (United States)

    Martínez-Cabrera, Hugo I; Estrada-Ruiz, Emilio

    2014-01-01

    The Olmos Formation (upper Campanian), with over 60 angiosperm leaf morphotypes, is Mexico's richest Cretaceous flora. Paleoclimate leaf physiognomy estimates indicate that the Olmos paleoforest grew under wet and warm conditions, similar to those present in modern tropical rainforests. Leaf surface area, tree size and climate reconstructions suggest that this was a highly productive system. Efficient carbon fixation requires hydraulic efficiency to meet the evaporative demands of the photosynthetic surface, but it comes at the expense of increased risk of drought-induced cavitation. Here we tested the hypothesis that the Olmos paleoforest had high hydraulic efficiency, but was prone to cavitation. We characterized the hydraulic properties of the Olmos paleoforest using theoretical conductivity (Ks), vessel composition (S) and vessel fraction (F), and measured drought resistance using vessel implosion resistance (t/b)h(2) and the water potential at which there is 50% loss of hydraulic conductivity (P50). We found that the Olmos paleoforest had high hydraulic efficiency, similar to that present in several extant tropical-wet or semi-deciduous forest communities. Remarkably, the fossil flora had the lowest (t/b)h(2), which, together with low median P50 (-1.9 MPa), indicate that the Olmos paleoforest species were extremely vulnerable to drought-induced cavitation. Our findings support paleoclimate inferences from leaf physiognomy and paleoclimatic models suggesting it represented a highly productive wet tropical rainforest. Our results also indicate that the Olmos Formation plants had a large range of water conduction strategies, but more restricted variation in cavitation resistance. These straightforward methods for measuring hydraulic properties, used herein for the first time, can provide useful information on the ecological strategies of paleofloras and on temporal shifts in ecological function of fossil forests chronosequences.

  1. Infection control implications of heterogeneous resistance mechanisms in carbapenem-resistant Enterobacteriaceae (CRE).

    Science.gov (United States)

    Goodman, K E; Simner, P J; Tamma, P D; Milstone, A M

    2016-01-01

    The Centers for Disease Control and Prevention (CDC) defines carbapenem-resistant Enterobacteriaceae (CRE) based upon a phenotypic demonstration of carbapenem resistance. However, considerable heterogeneity exists within this definitional umbrella. CRE may mechanistically differ by whether they do or do not produce carbapenemases. Moreover, patients can acquire CRE through multiple pathways: endogenously through antibiotic selective pressure on intestinal microbiota, exogenously through horizontal transmission or through a combination of these factors. Some evidence suggests that non-carbapenemase-producing CRE may be more frequently acquired by antibiotic exposure and carbapenemase-producing CRE via horizontal transmission, but definitive data are lacking. This review examines types of CRE resistance mechanisms, antibiotic exposure and horizontal transmission pathways of CRE acquisition, and the implications of these heterogeneities to the development of evidence-based CRE healthcare epidemiology policies. In our Expert Commentary & Five-Year View, we outline specific nosocomial CRE knowledge gaps and potential methodological approaches for their resolution.

  2. Inverse Porosity-Hydraulic Conductivity Relationship in Sand-and-Gravel Aquifers Determined From Analysis of Geophysical Well Logs: Implications for Transport Processes

    Science.gov (United States)

    Morin, R. H.

    2004-05-01

    It is intuitive to think of hydraulic conductivity K as varying directly and monotonically with porosity P in porous media. However, laboratory studies and field observations have documented a possible inverse relationship between these two parameters in unconsolidated deposits under certain grain-size distributions and packing arrangements. This was confirmed at two sites in sand-and-gravel aquifers on Cape Cod, Massachusetts, where sets of geophysical well logs were used to examine the interdependence of several aquifer properties. Along with K and P, the resistivity R and the natural-gamma activity G of the surrounding sediments were measured as a function of depth. Qualitative examination of field results from the first site was useful in locating a contaminant plume and inferred an inverse relation between K and P; this was substantiated by a rigorous multivariate analysis of log data collected from the second site where K and P were determined to respond in a bipolar manner among the four independent variables. Along with this result come some implications regarding our conceptual understanding of contaminant transport processes in the shallow subsurface. According to Darcy's law, the interstitial fluid velocity V is proportional to the ratio K/P and, consequently, a general inverse K-P relationship implies that values of V can extend over a much wider range than conventionally assumed. This situation introduces a pronounced flow stratification within these granular deposits that can result in large values of longitudinal dispersivity; faster velocities occur in already fast zones and slower velocities in already slow zones. An inverse K-P relationship presents a new perspective on the physical processes associated with groundwater flow and transport. Although the results of this study apply strictly to the Cape Cod aquifers, they may merit a re-evaluation of modeling approaches undertaken at other locations having similar geologic environments.

  3. Implications of the "observer effect" on modelling a long-term pumping test with hydraulically conductive boreholes in a discrete fracture network system.

    Science.gov (United States)

    Holton, D.; Frampton, A.; Cvetkovic, V.

    2006-12-01

    The Onkalo underground research facility for rock characterisation for nuclear waste disposal is located at Olkiluoto island, just off the Finnish coast in the Baltic Sea. Prior to the start of the excavation of the Onkalo facility, an extensive amount of hydraulic data has been collected during various pumping experiments from a large number of boreholes placed throughout an area of approximately 10 km2, reaching depths of 1000 meters below sea level. In particular, the hydraulic borehole data includes classical measurements of pressure, but also new measurements of flow rate and flow direction in boreholes (so called flow-logging). These measurements indicate large variations in heterogeneity and are a clear reflection of the discrete nature of the system. Here we present results from an ongoing project which aims to explore and asses the implications of these new flow-logging measurements to site descriptive modelling and modelling at performance assessment scales. The main challange of the first phase of this project is to obtain a greater understanding of a strongly heterogenious and anisotropic groundwater system in which open boreholes are located; that is, a system in which the observation boreholes themselves create new hydraulic conductive features of the groundwater system. The results presented are from recent hydraulic flow modelling simulations with a combined continuous porous media and discrete fracture network approach using a commercial finite-element software. An advantage of this approach is we may adapt a continuum mesh on the regional scale, were only a few conductive features are known, together with a local scale discrete fracture network approach, where detailed site-investigation has revealed a large amount of conductive features. Current findings indicate the system is sensitive to certain combinations of hydraulic features, and we quantify the significance of including these variations in terms of their implications for reduction of

  4. Semi-analytical prediction of hydraulic resistance and heat transfer for pipe and channel flows of water at supercritical pressure

    International Nuclear Information System (INIS)

    Laurien, E.

    2012-01-01

    Within the Generation IV International Forum the Supercritical Water Reactor is investigated. For its core design and safety analysis the efficient prediction of flow and heat transfer parameters such as the wall-shear stress and the heat-transfer coefficient for pipe and channel flows is needed. For circular pipe flows a numerical model based on the one-dimensional conservation equations of mass, momentum end energy in the radial direction is presented, referred to as a 'semi-analytical' method. An accurate, high-order numerical method is employed to evaluate previously derived analytical solutions of the governing equations. Flow turbulence is modeled using the algebraic approach of Prandtl/van-Karman, including a model for the buffer layer. The influence of wall roughness is taken into account by a new modified numerical damping function of the turbulence model. The thermo-hydraulic properties of water are implemented according to the international standard of 1997. This method has the potential to be used within a sub-channel analysis code and as wall-functions for CFD codes to predict the wall shear stress and the wall temperature. The present study presents a validation of the method with comparison of model results with experiments and multi-dimensional computational (CFD) studies in a wide range of flow parameters. The focus is laid on forced convection flows related to reactor design and near-design conditions. It is found, that the method can accurately predict the wall temperature even under deterioration conditions as they occur in the selected experiments (Yamagata el al. 1972 at 24.5 MPa, Ornatski et al. 1971 at 25.5 and Swenson et al. 1963 at 22.75 MPa). Comparison of the friction coefficient under high heat flux conditions including significant viscosity and density reductions near the wall with various correlations for the hydraulic resistance will be presented; the best agreement is achieve with the correlation of Pioro et al. 2004. It is

  5. Clinical implications of globally emerging azole resistance in Aspergillus fumigatus

    Science.gov (United States)

    Verweij, Paul E.

    2016-01-01

    Aspergillus fungi are the cause of an array of diseases affecting humans, animals and plants. The triazole antifungal agents itraconazole, voriconazole, isavuconazole and posaconazole are treatment options against diseases caused by Aspergillus. However, resistance to azoles has recently emerged as a new therapeutic challenge in six continents. Although de novo azole resistance occurs occasionally in patients during azole therapy, the main burden is the aquisition of resistance through the environment. In this setting, the evolution of resistance is attributed to the widespread use of azole-based fungicides. Although ubiquitously distributed, A. fumigatus is not a phytopathogen. However, agricultural fungicides deployed against plant pathogenic moulds such as Fusarium, Mycospaerella and A. flavus also show activity against A. fumigatus in the environment and exposure of non-target fungi is inevitable. Further, similarity in molecule structure between azole fungicides and antifungal drugs results in cross-resistance of A. fumigatus to medical azoles. Clinical studies have shown that two-thirds of patients with azole-resistant infections had no previous history of azole therapy and high mortality rates between 50% and 100% are reported in azole-resistant invasive aspergillosis. The resistance phenotype is associated with key mutations in the cyp51A gene, including TR34/L98H, TR53 and TR46/Y121F/T289A resistance mechanisms. Early detection of resistance is of paramount importance and if demonstrated, either with susceptibility testing or through molecular analysis, azole monotherapy should be avoided. Liposomal amphotericin B or a combination of voriconazole and an echinocandin are recomended for azole-resistant aspergillosis. This article is part of the themed issue ‘Tackling emerging fungal threats to animal health, food security and ecosystem resilience’. PMID:28080986

  6. Selection and use of fire-resistant hydraulic fluids for underground mining equipment. [Oil-in-water emulsions; water-in-oil emulsions; phosphate esters; chlorinated hydrocarbons

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, A J

    1981-02-01

    During the initial introduction of fire-resistant fluids to the Canadian underground mining industry, all hydraulic systems for which they were being considered were originally designed for operation with mineral oil. This meant that each system had to be individually examined and assessed with regard to its suitability in terms of acceptable component life and operation, at the same time as the selection of a fluid was being undertaken. Fluid selection by cost differential, toxicity content and fire resistancy was narrowed to types HFB and HFC, with HFB water-in-oil emulsion being the preferred fluid based on performance characteristics. By incorporating British mining industry experience and superior fluid types with practical trials, it was found that by modifing the design of some systems and slightly derating the operational parameters of individual components, it was possible to obtain a system performance comparable to that obtained when mineral oil was being used.

  7. Literature survey of heat transfer and hydraulic resistance of water, carbon dioxide, helium and other fluids at supercritical and near-critical pressures

    Energy Technology Data Exchange (ETDEWEB)

    Pioro, I.L.; Duffey, R.B

    2003-04-01

    This survey consists of 430 references, including 269 Russian publications and 161 Western publications devoted to the problems of heat transfer and hydraulic resistance of a fluid at near-critical and supercritical pressures. The objective of the literature survey is to compile and summarize findings in the area of heat transfer and hydraulic resistance at supercritical pressures for various fluids for the last fifty years published in the open Russian and Western literature. The analysis of the publications showed that the majority of the papers were devoted to the heat transfer of fluids at near-critical and supercritical pressures flowing inside a circular tube. Three major working fluids are involved: water, carbon dioxide, and helium. The main objective of these studies was the development and design of supercritical steam generators for power stations (utilizing water as a working fluid) in the 1950s, 1960s, and 1970s. Carbon dioxide was usually used as the modeling fluid due to lower values of the critical parameters. Helium, and sometimes carbon dioxide, were considered as possible working fluids in some special designs of nuclear reactors. (author)

  8. Identification and introgression of QTLs implicated in resistance to ...

    Indian Academy of Sciences (India)

    2015-12-08

    Dec 8, 2015 ... of polygenes which necessitated identification of quantitative-trait loci ... Genetic analysis of host resistance to SDM in maize ... Journal of Genetics, Vol. ..... The financial support for this research was provided by the Depart-.

  9. Hydraulic structures

    CERN Document Server

    Chen, Sheng-Hong

    2015-01-01

    This book discusses in detail the planning, design, construction and management of hydraulic structures, covering dams, spillways, tunnels, cut slopes, sluices, water intake and measuring works, ship locks and lifts, as well as fish ways. Particular attention is paid to considerations concerning the environment, hydrology, geology and materials etc. in the planning and design of hydraulic projects. It also considers the type selection, profile configuration, stress/stability calibration and engineering countermeasures, flood releasing arrangements and scouring protection, operation and maintenance etc. for a variety of specific hydraulic structures. The book is primarily intended for engineers, undergraduate and graduate students in the field of civil and hydraulic engineering who are faced with the challenges of extending our understanding of hydraulic structures ranging from traditional to groundbreaking, as well as designing, constructing and managing safe, durable hydraulic structures that are economical ...

  10. Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae.

    Science.gov (United States)

    Vedithi, Sundeep Chaitanya; Malhotra, Sony; Das, Madhusmita; Daniel, Sheela; Kishore, Nanda; George, Anuja; Arumugam, Shantha; Rajan, Lakshmi; Ebenezer, Mannam; Ascher, David B; Arnold, Eddy; Blundell, Tom L

    2018-03-22

    The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae). Missense mutations in the rpoB gene were identified as etiological factors for rifampin resistance in leprosy. In the present study, we identified mutations corresponding to rifampin resistance in relapsed leprosy cases from three hospitals in southern India which treat leprosy patients. DNA was extracted from skin biopsies of 35 relapse/multidrug therapy non-respondent leprosy cases, and PCR was performed to amplify the 276 bp rifampin resistance-determining region of the rpoB gene. PCR products were sequenced, and mutations were identified in four out of the 35 cases at codon positions D441Y, D441V, S437L and H476R. The structural and functional effects of these mutations were assessed in the context of three-dimensional comparative models of wild-type and mutant M. leprae RNA polymerase holoenzyme (RNAP), based on the recently solved crystal structures of RNAP of Mycobacterium tuberculosis, containing a synthetic nucleic acid scaffold and rifampin. The resistance mutations were observed to alter the hydrogen-bonding and hydrophobic interactions of rifampin and the 5' ribonucleotide of the growing RNA transcript. This study demonstrates that rifampin-resistant strains of M. leprae among leprosy patients in southern India are likely to arise from mutations that affect the drug-binding site and stability of RNAP.

  11. Relationship of visfatin level to pancreatic endocrine hormone level, HOMA-IR index, and HOMA β-cell index in overweight women who performed hydraulic resistance exercise.

    Science.gov (United States)

    Ha, Chang Ho; Swearingin, Brenda; Jeon, Yong Kyun

    2015-09-01

    [Purpose] This study aimed to examine the correlation of visfatin level to pancreatic endocrine hormone level, homeostasis model assessment of insulin resistance (HOMA-IR) index, and HOMA β-cell index in hydraulic resistance exercise. Furthermore, it investigated the relationship between visfatin level and other variables affected by exercise in overweight women. [Subjects and Methods] The exercise group trained for 12 weeks, 70 minutes/day, 5 days/week. Visfatin level, pancreatic endocrine hormone level, HOMA-IR index, and HOMA β-cell index were measured before and after the intervention. Based on the blood insulin and glucose concentrations, HOMA-IR index, the indicator of insulin resistance, and HOMA β-cell index, the indicator of insulin secretion level, were assessed. [Results] Interaction effects on visfatin level, insulin level, HOMA-IR index, and HOMA β-cell index were observed. Interaction effects on glucagon and glucose levels were not observed between the intervention groups. The correlations of visfatin level to insulin, glucagon, and glucose levels, and HOMA-IR and HOMA β-cell indexes were not significant for any of the subjects. [Conclusion] Therefore, the 12-week resistance exercise affected body composition, visfatin level, insulin level, HOMA-IR index, and HOMA β-cell index. Finally, visfatin was not related to insulin, glucagon, and glucose levels, and HOMA-IR and HOMA β-cell indexes.

  12. Leaching of Conductive Species: Implications to Measurements of Electrical Resistivity.

    Science.gov (United States)

    Spragg, R; Jones, S; Bu, Y; Lu, Y; Bentz, D; Snyder, K; Weiss, J

    2017-05-01

    Electrical tests have been used to characterize the microstructure of porous materials, the measured electrical response being determined by the contribution of the microstructure (porosity and tortuosity) and the electrical properties of the solution (conductivity of the pore solution) inside the pores of the material. This study has shown how differences in concentration between the pore solution (i.e., the solution in the pores) and the storage solution surrounding the test specimen leads to significant transport (leaching) of the conductive ionic species between the pore solution and the storage solution. Leaching influences the resistivity of the pore solution, thereby influencing electrical measurements on the bulk material from either a surface or uniaxial bulk resistance test. This paper has three main conclusions: 1.) Leaching of conductive species does occur with concentration gradients and that a diffusion based approach can be used to estimate the time scale associated with this change. 2.) Leaching of ions in the pore solution can influence resistivity measurements, and the ratio of surface to uniaxial resistivity can be used as a method to assess the presence of leaching and 3.) An estimation of the magnitude of leaching for standardized tests of cementitious materials.

  13. The use of antibiotics and implications for antimicrobial resistance development

    NARCIS (Netherlands)

    Loon, Harald-Jan van

    2004-01-01

    Antibiotic resistance has reached pandemic proportions and the increasing incidences have alarmed medical healthcare associations world wide. Some thirty years ago it was almost all infectious diseases were conquered, but over the last decades we have witnessed the re-emergence of known contagious

  14. Metabolic Capability of a Predominant Halanaerobium sp. in Hydraulically Fractured Gas Wells and Its Implication in Pipeline Corrosion

    Science.gov (United States)

    Liang, Renxing; Davidova, Irene A.; Marks, Christopher R.; Stamps, Blake W.; Harriman, Brian H.; Stevenson, Bradley S.; Duncan, Kathleen E.; Suflita, Joseph M.

    2016-01-01

    Microbial activity associated with produced water from hydraulic fracturing operations can lead to gas souring and corrosion of carbon-steel equipment. We examined the microbial ecology of produced water and the prospective role of the prevalent microorganisms in corrosion in a gas production field in the Barnett Shale. The microbial community was mainly composed of halophilic, sulfidogenic bacteria within the order Halanaerobiales, which reflected the geochemical conditions of highly saline water containing sulfur species (S2O32-, SO42-, and HS-). A predominant, halophilic bacterium (strain DL-01) was subsequently isolated and identified as belonging to the genus Halanaerobium. The isolate could degrade guar gum, a polysaccharide polymer used in fracture fluids, to produce acetate and sulfide in a 10% NaCl medium at 37°C when thiosulfate was available. To mitigate potential deleterious effects of sulfide and acetate, a quaternary ammonium compound was found to be an efficient biocide in inhibiting the growth and metabolic activity of strain DL-01 relative to glutaraldehyde and tetrakis (hydroxymethyl) phosphonium sulfate. Collectively, our findings suggest that predominant halophiles associated with unconventional shale gas extraction could proliferate and produce sulfide and acetate from the metabolism of polysaccharides used in hydraulic fracturing fluids. These metabolic products might be returned to the surface and transported in pipelines to cause pitting corrosion in downstream infrastructure. PMID:27446028

  15. Fate of antibiotic resistant bacteria and genes during wastewater chlorination: implication for antibiotic resistance control.

    Directory of Open Access Journals (Sweden)

    Qing-Bin Yuan

    Full Text Available This study investigated fates of nine antibiotic-resistant bacteria as well as two series of antibiotic resistance genes in wastewater treated by various doses of chlorine (0, 15, 30, 60, 150 and 300 mg Cl2 min/L. The results indicated that chlorination was effective in inactivating antibiotic-resistant bacteria. Most bacteria were inactivated completely at the lowest dose (15 mg Cl2 min/L. By comparison, sulfadiazine- and erythromycin-resistant bacteria exhibited tolerance to low chlorine dose (up to 60 mg Cl2 min/L. However, quantitative real-time PCRs revealed that chlorination decreased limited erythromycin or tetracycline resistance genes, with the removal levels of overall erythromycin and tetracycline resistance genes at 0.42 ± 0.12 log and 0.10 ± 0.02 log, respectively. About 40% of erythromycin-resistance genes and 80% of tetracycline resistance genes could not be removed by chlorination. Chlorination was considered not effective in controlling antimicrobial resistance. More concern needs to be paid to the potential risk of antibiotic resistance genes in the wastewater after chlorination.

  16. Comparison between gradient-dependent hydraulic conductivities of roots using the root pressure probe: the role of pressure propagations and implications for the relative roles of parallel radial pathways.

    Science.gov (United States)

    Bramley, Helen; Turner, Neil C; Turner, David W; Tyerman, Stephen D

    2007-07-01

    Hydrostatic pressure relaxations with the root pressure probe are commonly used for measuring the hydraulic conductivity (Lp(r)) of roots. We compared the Lp(r) of roots from species with different root hydraulic properties (Lupinus angustifolius L. 'Merrit', Lupinus luteus L. 'Wodjil', Triticum aestivum L. 'Kulin' and Zea mays L. 'Pacific DK 477') using pressure relaxations, a pressure clamp and osmotic gradients to induce water flow across the root. Only the pressure clamp measures water flow under steady-state conditions. Lp(r) determined by pressure relaxations was two- to threefold greater than Lp(r) from pressure clamps and was independent of the direction of water flow. Lp(r) (pressure clamp) was two- to fourfold higher than for Lp(r) (osmotic) for all species except Triticum aestivum where Lp(r) (pressure clamp) and Lp(r) (osmotic) were not significantly different. A novel technique was developed to measure the propagation of pressure through roots to investigate the cause of the differences in Lp(r). Root segments were connected between two pressure probes so that when root pressure (P(r)) was manipulated by one probe, the other probe recorded changes in P(r). Pressure relaxations did not induce the expected kinetics in pressure in the probe at the other end of the root when axial hydraulic conductance, and probe and root capacitances were accounted for. An electric circuit model of the root was constructed that included an additional capacitance in the root loaded by a series of resistances. This accounted for the double exponential kinetics for intact roots in pressure relaxation experiments as well as the reduced response observed with the double probe experiments. Although there were potential errors with all the techniques, we considered that the measurement of Lp(r) using the pressure clamp was the most unambiguous for small pressure changes, and provided that sufficient time was allowed for pressure propagation through the root. The differences in

  17. Hydraulic turbines

    International Nuclear Information System (INIS)

    Meluk O, G.

    1998-01-01

    The hydraulic turbines are defined according to the specific speed, in impulse turbines and in reaction turbines. Currently, the Pelton turbines (of impulse) and the Francis and Kaplan turbines (of reaction), they are the most important machines in the hydroelectric generation. The hydraulic turbines are capable of generating in short times, large powers, from its loads zero until the total load and reject the load instantly without producing damages in the operation. When the hydraulic resources are important, the hydraulic turbines are converted in the axle of the electric system. Its combination with thermoelectric generation systems, it allow the continuing supply of the variations in demand of energy system. The available hydraulic resource in Colombia is of 93085 MW, of which solely 9% is exploited, become 79% of all the electrical country generation, 21% remaining is provided by means of the thermoelectric generation

  18. Environmental concerns and regulatory initiatives related to hydraulic fracturing in shale gas formations: potential implications for North American gas supply

    Energy Technology Data Exchange (ETDEWEB)

    Sumi, Lisa [Earthworks (Canada)

    2010-09-15

    Shale gas resources have been referred to as a game changer for North America and it is expected that shale gas will account for over 30% of the natural gas production in North America by 2020. However, the development of this resource has raised several concerns, notably in terms of water use and contamination; more stringent regulations could be implemented in the coming years. The aim of this paper is to present the effect that more stringent regulations would have on gas development in the Marcellus shale, which accounts for 20% of North American shale gas production. Information on hydraulic fracturing and its environmental impacts is provided herein, along with information on the regulatory initiatives underway in the Marcellus shale region. This paper pointed out that novel regulations relating to shale gas development could significantly reduce the growth in shale gas production.

  19. Basic hydraulics

    CERN Document Server

    Smith, P D

    1982-01-01

    BASIC Hydraulics aims to help students both to become proficient in the BASIC programming language by actually using the language in an important field of engineering and to use computing as a means of mastering the subject of hydraulics. The book begins with a summary of the technique of computing in BASIC together with comments and listing of the main commands and statements. Subsequent chapters introduce the fundamental concepts and appropriate governing equations. Topics covered include principles of fluid mechanics; flow in pipes, pipe networks and open channels; hydraulic machinery;

  20. Environmental and Public Health Implications of Water Reuse: Antibiotics, Antibiotic Resistant Bacteria, and Antibiotic Resistance Genes

    Science.gov (United States)

    Hong, Pei-Ying; Al-Jassim, Nada; Ansari, Mohd Ikram; Mackie, Roderick I.

    2013-01-01

    Water scarcity is a global problem, and is particularly acute in certain regions like Africa, the Middle East, as well as the western states of America. A breakdown on water usage revealed that 70% of freshwater supplies are used for agricultural irrigation. The use of reclaimed water as an alternative water source for agricultural irrigation would greatly alleviate the demand on freshwater sources. This paradigm shift is gaining momentum in several water scarce countries like Saudi Arabia. However, microbial problems associated with reclaimed water may hinder the use of reclaimed water for agricultural irrigation. Of particular concern is that the occurrence of antibiotic residues in the reclaimed water can select for antibiotic resistance genes among the microbial community. Antibiotic resistance genes can be associated with mobile genetic elements, which in turn allow a promiscuous transfer of resistance traits from one bacterium to another. Together with the pathogens that are present in the reclaimed water, antibiotic resistant bacteria can potentially exchange mobile genetic elements to create the “perfect microbial storm”. Given the significance of this issue, a deeper understanding of the occurrence of antibiotics in reclaimed water, and their potential influence on the selection of resistant microorganisms would be essential. In this review paper, we collated literature over the past two decades to determine the occurrence of antibiotics in municipal wastewater and livestock manure. We then discuss how these antibiotic resistant bacteria may impose a potential microbial risk to the environment and public health, and the knowledge gaps that would have to be addressed in future studies. Overall, the collation of the literature in wastewater treatment and agriculture serves to frame and identify potential concerns with respect to antibiotics, antibiotic resistant bacteria, and antibiotic resistance genes in reclaimed water. PMID:27029309

  1. Environmental and Public Health Implications of Water Reuse: Antibiotics, Antibiotic Resistant Bacteria, and Antibiotic Resistance Genes

    KAUST Repository

    Hong, Pei-Ying; Aljassim, Nada I.; Ansari, Mohd Ikram; Mackie, Roderick

    2013-01-01

    Water scarcity is a global problem, and is particularly acute in certain regions like Africa, the Middle East, as well as the western states of America. A breakdown on water usage revealed that 70% of freshwater supplies are used for agricultural irrigation. The use of reclaimed water as an alternative water source for agricultural irrigation would greatly alleviate the demand on freshwater sources. This paradigm shift is gaining momentum in several water scarce countries like Saudi Arabia. However, microbial problems associated with reclaimed water may hinder the use of reclaimed water for agricultural irrigation. Of particular concern is that the occurrence of antibiotic residues in the reclaimed water can select for antibiotic resistance genes among the microbial community. Antibiotic resistance genes can be associated with mobile genetic elements, which in turn allow a promiscuous transfer of resistance traits from one bacterium to another. Together with the pathogens that are present in the reclaimed water, antibiotic resistant bacteria can potentially exchange mobile genetic elements to create the “perfect microbial storm”. Given the significance of this issue, a deeper understanding of the occurrence of antibiotics in reclaimed water, and their potential influence on the selection of resistant microorganisms would be essential. In this review paper, we collated literature over the past two decades to determine the occurrence of antibiotics in municipal wastewater and livestock manure. We then discuss how these antibiotic resistant bacteria may impose a potential microbial risk to the environment and public health, and the knowledge gaps that would have to be addressed in future studies. Overall, the collation of the literature in wastewater treatment and agriculture serves to frame and identify potential concerns with respect to antibiotics, antibiotic resistant bacteria, and antibiotic resistance genes in reclaimed water.

  2. Environmental and Public Health Implications of Water Reuse: Antibiotics, Antibiotic Resistant Bacteria, and Antibiotic Resistance Genes

    Directory of Open Access Journals (Sweden)

    Roderick I. Mackie

    2013-07-01

    Full Text Available Water scarcity is a global problem, and is particularly acute in certain regions like Africa, the Middle East, as well as the western states of America. A breakdown on water usage revealed that 70% of freshwater supplies are used for agricultural irrigation. The use of reclaimed water as an alternative water source for agricultural irrigation would greatly alleviate the demand on freshwater sources. This paradigm shift is gaining momentum in several water scarce countries like Saudi Arabia. However, microbial problems associated with reclaimed water may hinder the use of reclaimed water for agricultural irrigation. Of particular concern is that the occurrence of antibiotic residues in the reclaimed water can select for antibiotic resistance genes among the microbial community. Antibiotic resistance genes can be associated with mobile genetic elements, which in turn allow a promiscuous transfer of resistance traits from one bacterium to another. Together with the pathogens that are present in the reclaimed water, antibiotic resistant bacteria can potentially exchange mobile genetic elements to create the “perfect microbial storm”. Given the significance of this issue, a deeper understanding of the occurrence of antibiotics in reclaimed water, and their potential influence on the selection of resistant microorganisms would be essential. In this review paper, we collated literature over the past two decades to determine the occurrence of antibiotics in municipal wastewater and livestock manure. We then discuss how these antibiotic resistant bacteria may impose a potential microbial risk to the environment and public health, and the knowledge gaps that would have to be addressed in future studies. Overall, the collation of the literature in wastewater treatment and agriculture serves to frame and identify potential concerns with respect to antibiotics, antibiotic resistant bacteria, and antibiotic resistance genes in reclaimed water.

  3. Environmental and Public Health Implications of Water Reuse: Antibiotics, Antibiotic Resistant Bacteria, and Antibiotic Resistance Genes

    KAUST Repository

    Hong, Pei-Ying

    2013-07-31

    Water scarcity is a global problem, and is particularly acute in certain regions like Africa, the Middle East, as well as the western states of America. A breakdown on water usage revealed that 70% of freshwater supplies are used for agricultural irrigation. The use of reclaimed water as an alternative water source for agricultural irrigation would greatly alleviate the demand on freshwater sources. This paradigm shift is gaining momentum in several water scarce countries like Saudi Arabia. However, microbial problems associated with reclaimed water may hinder the use of reclaimed water for agricultural irrigation. Of particular concern is that the occurrence of antibiotic residues in the reclaimed water can select for antibiotic resistance genes among the microbial community. Antibiotic resistance genes can be associated with mobile genetic elements, which in turn allow a promiscuous transfer of resistance traits from one bacterium to another. Together with the pathogens that are present in the reclaimed water, antibiotic resistant bacteria can potentially exchange mobile genetic elements to create the “perfect microbial storm”. Given the significance of this issue, a deeper understanding of the occurrence of antibiotics in reclaimed water, and their potential influence on the selection of resistant microorganisms would be essential. In this review paper, we collated literature over the past two decades to determine the occurrence of antibiotics in municipal wastewater and livestock manure. We then discuss how these antibiotic resistant bacteria may impose a potential microbial risk to the environment and public health, and the knowledge gaps that would have to be addressed in future studies. Overall, the collation of the literature in wastewater treatment and agriculture serves to frame and identify potential concerns with respect to antibiotics, antibiotic resistant bacteria, and antibiotic resistance genes in reclaimed water.

  4. Characterisation of ALS genes in the polyploid species Schoenoplectus mucronatus and implications for resistance management.

    Science.gov (United States)

    Scarabel, Laura; Locascio, Antonella; Furini, Antonella; Sattin, Maurizio; Varotto, Serena

    2010-03-01

    The polyploid weed Schoenoplectus mucronatus (L.) Palla has evolved target-site resistance to ALS-inhibiting herbicides in Italian rice crops. Molecular and genetic characterisation of the resistance mechanism is relevant to the evolution and management of herbicide resistance. The authors aimed (a) to study the organisation of the target-site loci in two field-selected S. mucronatus populations with different cross-resistance patterns, (b) to identify the mutations endowing resistance to ALS inhibitors and determine the role of these mutations by using transgenesis and (c) to analyse the implications for the management of the S. mucronatus populations. Two complete ALS genes (ALS1 and ALS2) having an intron and a third partial intronless ALS gene (ALS3) were identified. The presence of multiple ALS genes was confirmed by Southern blot analyses, and ALS loci were characterised by examining cytosine methylation. In S. mucronatus leaves, the transcripts of ALS1, ALS2 and ALS3 were detected. Two mutations endowing resistance (Pro(197) to His and Trp(574) to Leu) were found in both resistant populations, but at different frequencies. Tobacco plants transformed with the two resistant alleles indicated that the Pro(197)-to-His substitution conferred resistance to SU and TP herbicides, while the allele with the Trp(574)-to-Leu substitution conferred cross-resistance to SU, TP, IMI and PTB herbicides. Schoenoplectus mucronatus has multiple ALS genes characterised by methylated sites that can influence the expression profile. The two mutated alleles proved to be responsible for ALS resistance. At population level, the resistance pattern depends on the frequency of various resistant genotypes, and this influences the efficacy of various ALS-inhibiting herbicides.

  5. Hydraulic Structures

    Data.gov (United States)

    Department of Homeland Security — This table is required whenever hydraulic structures are shown in the flood profile. It is also required if levees are shown on the FIRM, channels containing the...

  6. Individual variation in resisting temptation: implications for addiction

    Science.gov (United States)

    Saunders, Benjamin T.; Robinson, Terry E.

    2013-01-01

    When exposed to the sights, sounds, smells and/or places that have been associated with rewards, such as food or drugs, some individuals have difficulty resisting the temptation to seek out and consume them. Others have less difficulty restraining themselves. Thus, Pavlovian reward cues may motivate maladaptive patterns of behavior to a greater extent in some individuals than in others. We are just beginning to understand the factors underlying individual differences in the extent to which reward cues acquire powerful motivational properties, and therefore, the ability to act as incentive stimuli. Here we review converging evidence from studies in both human and non-human animals suggesting that a subset of individuals are more “cue reactive”, in that certain reward cues are more likely to attract these individuals to them and motivate actions to get them. We suggest that those individuals for whom Pavlovian reward cues become especially powerful incentives may be more vulnerable to impulse control disorders, such as binge eating and addiction. PMID:23438893

  7. Individual variation in resisting temptation: implications for addiction.

    Science.gov (United States)

    Saunders, Benjamin T; Robinson, Terry E

    2013-11-01

    When exposed to the sights, sounds, smells and/or places that have been associated with rewards, such as food or drugs, some individuals have difficulty resisting the temptation to seek out and consume them. Others have less difficulty restraining themselves. Thus, Pavlovian reward cues may motivate maladaptive patterns of behavior to a greater extent in some individuals than in others. We are just beginning to understand the factors underlying individual differences in the extent to which reward cues acquire powerful motivational properties, and therefore, the ability to act as incentive stimuli. Here we review converging evidence from studies in both human and non-human animals suggesting that a subset of individuals are more "cue reactive", in that certain reward cues are more likely to attract these individuals to them and motivate actions to get them. We suggest that those individuals for whom Pavlovian reward cues become especially powerful incentives may be more vulnerable to impulse control disorders, such as binge eating and addiction. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Hydraulics of outburst floods spilling over a steep-walled canyon: Implications for paleo-discharges on Mars

    Science.gov (United States)

    Lapotre, Mathieu; Lamb, Michael

    2013-04-01

    Canyons carved by outburst floods are common landforms on Earth and Mars. These canyons are generally found in fractured basalts and jointed sedimentary rocks. Flood-carved canyons commonly have steep headwalls and a roughly constant width, and are often thought to have formed from upstream headwall propagation due to waterfall erosion. Because morphology is readily available from satellite imagery, these canyons offer a unique opportunity to quantify the discharge of rare, catastrophic paleo-floods on Earth and Mars. However, mechanistic relationships that relate canyon size to flood discharge have yet to be developed. We propose that the width of a canyon headwall in fractured rock is set by the spatial distribution of erosion around the rim of the canyon, which is controlled by the distribution of shear stresses induced by the overflowing water as it is focused into the canyon head. We test this hypothesis by performing a series of numerical simulations of flood-water focusing using ANUGA Hydro, a 2D-depth averaged, fully turbulent, hydraulic numerical modeling suite allowing for Froude-number transitions. The numerical simulations were designed to explore five dimensionless variables: the aspect ratio of the canyon (length normalized by width), the canyon width to flood-water width ratio, the canyon width to normal-flow depth ratio, the Froude number, and the topographic gradient upstream of the canyon. Preliminary results show that flow focusing leads to increased shear stresses at the canyon head compared to the sides of the canyon for subcritical floods and higher canyon aspect ratios. This suggests that proto-canyons start growing from a topographic defect in all directions until they reach a critical length for the side walls to dry. Once this critical length is attained, canyons focus most of the flood waters into their heads, and propagate upstream only, maintaining roughly constant widths. Preliminary results suggest that canyon width may be used to

  9. Hydraulic integration and shrub growth form linked across continental aridity gradients.

    Science.gov (United States)

    H. Jochen Schenk; Susana Espino; Christine M. Goedhart; Marisa Nordenstahl; Hugo I. Martinez Cabrera; Cynthia S. Jones

    2009-01-01

    Both engineered hydraulic systems and plant hydraulic systems are protected against failure by resistance, reparability, and redundancy. A basic rule of reliability engineering is that the level of...

  10. Localized Glacier Deformation Associated with Filling and Draining of a Glacier-Dammed Lake and Implications for Outburst Flood Hydraulics

    Science.gov (United States)

    Cunico, M. L.; Walder, J. S.; Fountain, A. G.; Trabant, D. C.

    2001-12-01

    "viscous" response of the glacier to the flexural stresses imposed by the subglacial water wedge, or (ii) movement of water from the lake into temporary storage--a sort of hydraulic jacking. We favor the latter explanation and suggest that as the lake drained, water "backed up" from a main drainage channel into a basal cavity system and perhaps englacial voids as well; the stored water then drained back out as pressure eventually fell in the main channel. Assuming that all the vertical downdrop of the ice is due to the evacuation of water, the total volume of the putative subglacial "wedge" plus the water released from distributed storage is about 7 to 11 million cubic meters, or about 25 to 40% of the volume of the subaerial lake.

  11. Robust Prediction of Hydraulic Roughness

    Science.gov (United States)

    2011-03-01

    Manning’s n were required as input for further hydraulic analyses with HEC - RAS . HYDROCAL was applied to compare different estimates of resistance... River Restoration Science Synthesis (NRRSS) demonstrated that, in 2007, river and stream restoration projects and funding were at an all time high...behavior makes this parameter very difficult to quan- tify repeatedly and accurately. A fundamental concept of hydraulic theory in the context of river

  12. Antibiotic resistant Escherichia coli in southeastern Australian pig herds and implications for surveillance.

    Science.gov (United States)

    van Breda, L K; Dhungyel, O P; Ward, M P

    2018-02-01

    To investigate public health implications of antibiotics to control post-weaning scours, we surveyed 22 commercial pig herds in southeastern Australia. Fifty faecal samples per herd were collected from pre- and post-weaned piglets. Presumptive Escherichia coli isolates were confirmed by MALDI-TOF MS. Isolates (n = 325) were screened for susceptibility to 19 veterinary antibiotics using MIC broth microdilution. All 325 E. coli isolates underwent further testing against 27 antibiotics used in human medicine and were screened for ETEC adhesin and enterotoxin genes (F4 (K88), F5 (K99), F6 (987P), F18, F41, STa, STb, Stx2e and LT) by multiplex PCR. Isolates identified as phenotypically resistant to third-generation cephalosporin (3GC) and aminoglycoside antibiotics were screened by multiplex PCR/reverse line blot to detect common β-lactam and aminoglycosides resistance genes, confirmed by sequencing. Twenty (6.1%) of the E. coli isolates were resistant to 3GC antibiotics and 24 (7.4%) to the aminoglycoside antibiotic gentamicin. Genetic analysis revealed six different extended spectrum β-lactamase (ESBL) genes (blaCTX-M-1, -14, -15, -27, blaSHV-12 and blaCMY-2-like genes), four of which have not been previously reported in Australian pigs. Critically, the prevalence of 3GC resistance was higher in non-pathogenic (non-ETEC) isolates and those from clinically normal (non-diarrhoeal) samples. This highlights the importance of non-ETECE. coli as reservoirs of antimicrobial resistance genes in piglet pens. Antimicrobial resistance surveillance in pig production focused on diagnostic specimens from clinically-affected animals might be potentially misleading. We recommend that surveillance for emerging antimicrobial resistance such as to 3GC antibiotics should include clinically healthy pigs. © 2017 Blackwell Verlag GmbH.

  13. Impacts of Vegetation Growth on Reach-scale Flood Hydraulics in a Sand-bed River and the Implications for Vegetation-morphology Coevolution

    Science.gov (United States)

    Box, S.; Wilcox, A. C.

    2017-12-01

    Vegetation alters flood hydraulics and geomorphic response, yet quantifying and predicting such responses across spatial and temporal scales remains challenging. Plant- and patch-scale studies consistently show that vegetation increases local hydraulic variability, yet reach-scale hydrodynamic models often assume vegetation has a spatially homogeneous effect on hydraulics. Using Nays2DH in iRIC (International River Interface Cooperative), we model the effect of spatially heterogeneous vegetation on a series of floods with varying antecedent vegetation conditions in a sand-bed river in western Arizona, taking advantage of over a decade of data on a system that experienced substantial geomorphic, hydrologic, and ecosystem changes. We show that pioneer woody seedlings (Tamarix, Populus, Salix) and cattail (Typha) increase local hydraulic variability, including velocity and bed shear stress, along individual cross sections, predominantly by decreasing velocity in zones of vegetation establishment and growth and increasing velocity in unvegetated areas, with analogous effects on shear stress. This was especially prominent in a study reach where vegetation growth contributed to thalweg incision relative to a vegetated bar. Evaluation of these results in the context of observed geomorphic response to floods elucidates mechanisms by which vegetation and channel morphology coevolve at a reach scale. By quantifying the influence of spatially heterogeneous vegetation on reach-scale hydraulics, we demonstrate that plant- and patch-scale research on vegetation hydraulics is applicable to ecogeomorphology at the reach scale.

  14. Altered Expression of Genes Implicated in Xylan Biosynthesis Affects Penetration Resistance against Powdery Mildew.

    Science.gov (United States)

    Chowdhury, Jamil; Lück, Stefanie; Rajaraman, Jeyaraman; Douchkov, Dimitar; Shirley, Neil J; Schwerdt, Julian G; Schweizer, Patrick; Fincher, Geoffrey B; Burton, Rachel A; Little, Alan

    2017-01-01

    Heteroxylan has recently been identified as an important component of papillae, which are formed during powdery mildew infection of barley leaves. Deposition of heteroxylan near the sites of attempted fungal penetration in the epidermal cell wall is believed to enhance the physical resistance to the fungal penetration peg and hence to improve pre-invasion resistance. Several glycosyltransferase (GT) families are implicated in the assembly of heteroxylan in the plant cell wall, and are likely to work together in a multi-enzyme complex. Members of key GT families reported to be involved in heteroxylan biosynthesis are up-regulated in the epidermal layer of barley leaves during powdery mildew infection. Modulation of their expression leads to altered susceptibility levels, suggesting that these genes are important for penetration resistance. The highest level of resistance was achieved when a GT43 gene was co-expressed with a GT47 candidate gene, both of which have been predicted to be involved in xylan backbone biosynthesis. Altering the expression level of several candidate heteroxylan synthesis genes can significantly alter disease susceptibility. This is predicted to occur through changes in the amount and structure of heteroxylan in barley papillae.

  15. Molecular markers of anti-malarial drug resistance in Lahj Governorate, Yemen: baseline data and implications

    Directory of Open Access Journals (Sweden)

    Chance Michael L

    2011-08-01

    Full Text Available Abstract Background This is an investigation of anti-malarial molecular markers coupled with a therapeutic efficacy test of chloroquine (CQ against falciparum malaria in an area of unstable malaria in Lahj Governorate, Yemen. The study was aimed at assessment of therapeutic response to CQ and elucidation of baseline information on molecular markers for Plasmodium falciparum resistance against CQ and sulphadoxine/pyrimethamine (SP. Methods Between 2002 and 2003 the field test was conducted according to the standard WHO protocol to evaluate the therapeutic efficacy of CQ in 124 patients with falciparum malaria in an endemic area in Lahj Governorate in Yemen. Blood samples collected during this study were analysed for P. falciparum chloroquine resistance transporter gene (pfcrt-76 polymorphisms, mutation pfcrt-S163R and the antifolate resistance-associated mutations dihydrofolate reductase (dhfr-C59R and dihydropteroate synthase (dhps-K540E. Direct DNA sequencing of the pfcrt gene from three representative field samples was carried out after DNA amplification of the 13 exons of the pfcrt gene. Results Treatment failure was detected in 61% of the 122 cases that completed the 14-day follow-up. The prevalence of mutant pfcrt T76 was 98% in 112 amplified pre-treatment samples. The presence of pfcrt T76 was poorly predictive of in vivo CQ resistance (PPV = 61.8%, 95% CI = 52.7-70.9. The prevalence of dhfr Arg-59 mutation in 99 amplified samples was 5%, while the dhps Glu-540 was not detected in any of 119 amplified samples. Sequencing the pfcrt gene confirmed that Yemeni CQ resistant P. falciparum carry the old world (Asian and African CQ resistant haplotype CVIETSESI at positions 72,73,74,75,76,220,271, 326 and 371. Conclusion This is the first study to report baseline information on the characteristics and implications of anti-malarial drug resistance markers in Yemen. It is also the first report of the haplotype associated with CQR P. falciparum

  16. Molecular markers of anti-malarial drug resistance in Lahj Governorate, Yemen: baseline data and implications.

    Science.gov (United States)

    Mubjer, Reem A; Adeel, Ahmed A; Chance, Michael L; Hassan, Amir A

    2011-08-21

    This is an investigation of anti-malarial molecular markers coupled with a therapeutic efficacy test of chloroquine (CQ) against falciparum malaria in an area of unstable malaria in Lahj Governorate, Yemen. The study was aimed at assessment of therapeutic response to CQ and elucidation of baseline information on molecular markers for Plasmodium falciparum resistance against CQ and sulphadoxine/pyrimethamine (SP). Between 2002 and 2003 the field test was conducted according to the standard WHO protocol to evaluate the therapeutic efficacy of CQ in 124 patients with falciparum malaria in an endemic area in Lahj Governorate in Yemen. Blood samples collected during this study were analysed for P. falciparum chloroquine resistance transporter gene (pfcrt)-76 polymorphisms, mutation pfcrt-S163R and the antifolate resistance-associated mutations dihydrofolate reductase (dhfr)-C59R and dihydropteroate synthase (dhps)-K540E. Direct DNA sequencing of the pfcrt gene from three representative field samples was carried out after DNA amplification of the 13 exons of the pfcrt gene. Treatment failure was detected in 61% of the 122 cases that completed the 14-day follow-up. The prevalence of mutant pfcrt T76 was 98% in 112 amplified pre-treatment samples. The presence of pfcrt T76 was poorly predictive of in vivo CQ resistance (PPV = 61.8%, 95% CI = 52.7-70.9). The prevalence of dhfr Arg-59 mutation in 99 amplified samples was 5%, while the dhps Glu-540 was not detected in any of 119 amplified samples. Sequencing the pfcrt gene confirmed that Yemeni CQ resistant P. falciparum carry the old world (Asian and African) CQ resistant haplotype CVIETSESI at positions 72,73,74,75,76,220,271, 326 and 371. This is the first study to report baseline information on the characteristics and implications of anti-malarial drug resistance markers in Yemen. It is also the first report of the haplotype associated with CQR P. falciparum parasites from Yemen. Mutant pfcrtT76 is highly prevalent but it

  17. Hydraulic manipulator

    International Nuclear Information System (INIS)

    Sinha, A.K.; Srikrishnamurty, G.

    1990-01-01

    Successful operation of nuclear plant is largely dependent on safe handling of radio-active material. In order to reduce this handling problem and minimise the exposure of radiation, various handling equipment and manipulators have been developed according to the requirements. Manufacture of nuclear fuel, which is the most important part of the nuclear industry, involves handling of uranium ingots weighing approximately 250 kg. This paper describes a specially designed hydraulic manipulator for handling of the ingots in a limited space. It was designed to grab and handle the ingots in any position. This has following drive motions: (1)gripping and releasing, (2)lifting and lowering (z-motion), (3)rotation about the horizontal axis (azimuth drive), (4)rotation about the job axis, and (5)rotation about the vertical axis. For horizontal motion (X and Y axis motion) this equipment is mounted on a motorised trolley, so that it can move inside the workshop. For all drives except the rotation about the job axis, hydraulic cylinders have been used with a battery operated power pack. Trolley drive is also given power from same battery. This paper describes the design aspects of this manipulator. (author). 4 figs

  18. Fire Resistant Aircraft Hydraulic System.

    Science.gov (United States)

    1982-07-01

    Chemical Division "Fluorinert" FC-48 - Fluorinated Hydrocarbon "Fluorinert" FC-70 - Fluorinated Hydrocarbon Montedison S. p. A. "Fomblin" Z-04...forming substances such as varnish which could seize a spool valve or other small-clearance sliding surfaces. The test setup is pictorially described in...breakdown products such as solid particles, gels, and sludge’can plug system filters and even small fluid passages, nozzles, and orifices. Varnish -like

  19. Newly approved antibiotics and antibiotics reserved for resistant infections: Implications for emergency medicine.

    Science.gov (United States)

    Mazer-Amirshahi, Maryann; Pourmand, Ali; May, Larissa

    2017-01-01

    Millions of patients are evaluated every year in the emergency department (ED) for bacterial infections. Emergency physicians often diagnose and prescribe initial antibiotic therapy for a variety of bacterial infections, ranging from simple urinary tract infections to severe sepsis. In life-threatening infections, inappropriate choice of initial antibiotic has been shown to increase morbidity and mortality. As such, initiation of appropriate antibiotic therapy on the part of the emergency physician is critical. Increasing rates of antibiotic resistance, drug allergies, and antibiotic shortages further complicates the choice of antibiotics. Patients may have a history of prior resistant infections or culture data indicating that common first-line antibiotics used in the ED may be ineffective. In recent years, there have been several new antibiotic approvals as well as renewed interest in second and third line antibiotics because of the aforementioned concerns. In addition, several newly approved antibiotics have the advantage of being administered once weekly or even as a single infusion, which has the potential to decrease hospitalizations and healthcare costs. This article reviews newly approved antibiotics and antibiotics used to treat resistant infections with a focus on implications for emergency medicine. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Reclaimed water as a reservoir of antibiotic resistance genes: distribution system and irrigation implications

    Directory of Open Access Journals (Sweden)

    Nicole L Fahrenfeld

    2013-05-01

    Full Text Available Treated wastewater is increasingly being reused to achieve sustainable water management in arid regions. The objective of this study was to quantify the distribution of antibiotic resistance genes (ARGs in recycled water, particularly after it has passed through the distribution system, and to consider point-of-use implications for soil irrigation. Three separate reclaimed wastewater distribution systems in the western U.S. were examined. Quantitative polymerase chain reaction (qPCR was used to quantify ARGs corresponding to resistance to sulfonamides (sul1, sul2, macrolides (ermF, tetracycline (tet(A, tet(O, glycopeptides (vanA, and methicillin (mecA, in addition to genes present in waterborne pathogens Legionella pneumophila (Lmip, Escherichia coli (gadAB, and Pseudomonas aeruginosa (ecfx, gyrB. In a parallel lab study, the effect of irrigating an agricultural soil with secondary, chlorinated, or dechlorinated wastewater effluent was examined in batch microcosms. A broader range of ARGs were detected after the reclaimed water passed through the distribution systems, highlighting the importance of considering bacterial re-growth and the overall water quality at the point of use. Screening for pathogens with qPCR indicated presence of Lmip and gadAB genes, but not ecfx or gyrB. In the lab study, chlorination was observed to reduce 16S rRNA and sul2 gene copies in the wastewater effluent, while dechlorination had no apparent effect. ARGs levels did not change with time in soil slurries incubated after a single irrigation event with any of the effluents. However, when irrigated repeatedly with secondary wastewater effluent (not chlorinated or dechlorinated, elevated levels of sul1 and sul2 were observed. This study suggests that reclaimed water may be an important reservoir of ARGs, especially at the point of use, and that attention should be directed towards the fate of ARGs in irrigation water and the implications for human health.

  1. Antibiotic cross-resistance in the lab and resistance co-occurrence in the clinic: Discrepancies and implications in E.coli.

    Science.gov (United States)

    Obolski, Uri; Dellus-Gur, Eynat; Stein, Gideon Y; Hadany, Lilach

    2016-06-01

    Antibiotic resistance is an important public health issue, and vast resources are invested in researching new ways to fight it. Recent experimental works have shown that resistance to some antibiotics can result in increased susceptibility to others, namely induce cross-sensitivity. This phenomenon could be utilized to increase efficiency of antibiotic treatment strategies that minimize resistance. However, as conditions in experimental settings and in the clinic may differ substantially, the implications of cross-sensitivity for clinical settings are not guaranteed and should be examined. In this work we analyzed data of Escherichia coli isolates from patients' blood, sampled in Rabin Medical Center, Israel, to examine co-occurrence of resistance to antibiotics in the clinic. We compared the co-occurrence patterns with cross-sensitivity patterns observed in the lab. Our data showed only positively associated occurrence of resistance, even with antibiotics that were shown to induce cross-sensitivity in laboratory conditions. We used a mathematical model to examine the potential effects of cross-sensitivity versus co-occurrence on the spread of drug resistance. We conclude that resistance frequencies in the clinic can have a substantial effect on the success of treatment strategies, and should be considered alongside experimental evidence of cross-sensitivity. Copyright © 2016. Published by Elsevier B.V.

  2. Antibiotic-resistant Pseudomonas aeruginosa infection in patients with bronchiectasis: prevalence, risk factors and prognostic implications

    Directory of Open Access Journals (Sweden)

    Gao YH

    2018-01-01

    Full Text Available Yong-hua Gao,1,* Wei-jie Guan,2,* Ya-nan Zhu,3 Rong-chang Chen,2 Guo-jun Zhang1 1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 2State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 3Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China *These authors contributed equally to this work Background and aims: Pseudomonas aeruginosa (PA is the most common pathogen in bronchiectasis and frequently develops resistance to multiple classes of antibiotics, but little is known about the clinical impacts of PA-resistant (PA-R isolates on bronchiectasis. We, therefore, investigated the prevalence, risk factors and prognostic implications of PA-R isolates in hospitalized bronchiectasis patients.Patients and methods: Between June 2011 and July 2016, data from adult bronchiectasis patients isolated with PA at the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed. PA was classified as PA-R in case antibiogram demonstrated resistance on at least one occasion.Results: Seven hundred forty-seven bronchiectasis patients were assessed. Of these, 147 (19.7% had PA isolate in the sputum or bronchoscopic culture. PA-R and PA-sensitive accounted for 88 (59.9% and 59 (31.1% patients, respectively. In multivariate model, factors associated with PA-R isolate in bronchiectasis included prior exposure to antibiotics (odds ratio [OR] =6.18, three or more exacerbations in the previous year (OR =2.81, higher modified Medical Research Council dyspnea scores (OR =1.93 and greater radiologic severity (OR =1.15. During follow-up (median: 26 months; interquartile range: 6–59 months, 36 patients died, of whom 24 (66

  3. Hydraulic Hybrid Vehicles

    Science.gov (United States)

    EPA and the United Parcel Service (UPS) have developed a hydraulic hybrid delivery vehicle to explore and demonstrate the environmental benefits of the hydraulic hybrid for urban pick-up and delivery fleets.

  4. A novel radiation-induced p53 mutation is not implicated in radiation resistance via a dominant-negative effect.

    Directory of Open Access Journals (Sweden)

    Yunguang Sun

    Full Text Available Understanding the mutations that confer radiation resistance is crucial to developing mechanisms to subvert this resistance. Here we describe the creation of a radiation resistant cell line and characterization of a novel p53 mutation. Treatment with 20 Gy radiation was used to induce mutations in the H460 lung cancer cell line; radiation resistance was confirmed by clonogenic assay. Limited sequencing was performed on the resistant cells created and compared to the parent cell line, leading to the identification of a novel mutation (del at the end of the DNA binding domain of p53. Levels of p53, phospho-p53, p21, total caspase 3 and cleaved caspase 3 in radiation resistant cells and the radiation susceptible (parent line were compared, all of which were found to be similar. These patterns held true after analysis of p53 overexpression in H460 cells; however, H1299 cells transfected with mutant p53 did not express p21, whereas those given WT p53 produced a significant amount, as expected. A luciferase assay demonstrated the inability of mutant p53 to bind its consensus elements. An MTS assay using H460 and H1299 cells transfected with WT or mutant p53 showed that the novel mutation did not improve cell survival. In summary, functional characterization of a radiation-induced p53 mutation in the H460 lung cancer cell line does not implicate it in the development of radiation resistance.

  5. Arabidopsis thaliana resistance to fusarium oxysporum 2 implicates tyrosine-sulfated peptide signaling in susceptibility and resistance to root infection.

    Directory of Open Access Journals (Sweden)

    Yunping Shen

    2013-05-01

    Full Text Available In the plant Arabidopsis thaliana, multiple quantitative trait loci (QTLs, including RFO2, account for the strong resistance of accession Columbia-0 (Col-0 and relative susceptibility of Taynuilt-0 (Ty-0 to the vascular wilt fungus Fusarium oxysporum forma specialis matthioli. We find that RFO2 corresponds to diversity in receptor-like protein (RLP genes. In Col-0, there is a tandem pair of RLP genes: RFO2/At1g17250 confers resistance while RLP2 does not. In Ty-0, the highly diverged RFO2 locus has one RLP gene conferring weaker resistance. While the endogenous RFO2 makes a modest contribution to resistance, transgenic RFO2 provides strong pathogen-specific resistance. The extracellular leucine-rich repeats (eLRRs in RFO2 and RLP2 are interchangeable for resistance and remarkably similar to eLRRs in the receptor-like kinase PSY1R, which perceives tyrosine-sulfated peptide PSY1. Reduced infection in psy1r and mutants of related phytosulfokine (PSK receptor genes PSKR1 and PSKR2 shows that tyrosine-sulfated peptide signaling promotes susceptibility. The related eLRRs in RFO2 and PSY1R are not interchangeable; and expression of the RLP nPcR, in which eLRRs in RFO2 are replaced with eLRRs in PSY1R, results in constitutive resistance. Counterintuitively, PSY1 signaling suppresses nPcR because psy1r nPcR is lethal. The fact that PSK signaling does not similarly affect nPcR argues that PSY1 signaling directly downregulates the expression of nPcR. Our results support a speculative but intriguing model to explain RFO2's role in resistance. We propose that F. oxysporum produces an effector that inhibits the normal negative feedback regulation of PSY1R, which stabilizes PSY1 signaling and induces susceptibility. However, RFO2, acting as a decoy receptor for PSY1R, is also stabilized by the effector and instead induces host immunity. Overall, the quantitative resistance of RFO2 is reminiscent of the better-studied monogenic resistance traits.

  6. Effective dominance of resistance of Spodoptera frugiperda to Bt maize and cotton varieties: implications for resistance management

    Science.gov (United States)

    Horikoshi, Renato J.; Bernardi, Daniel; Bernardi, Oderlei; Malaquias, José B.; Okuma, Daniela M.; Miraldo, Leonardo L.; Amaral, Fernando S. De A. E.; Omoto, Celso

    2016-10-01

    The resistance of fall armyworm (FAW), Spodoptera frugiperda, has been characterized to some Cry and Vip3A proteins of Bacillus thuringiensis (Bt) expressed in transgenic maize in Brazil. Here we evaluated the effective dominance of resistance based on the survival of neonates from selected Bt-resistant, heterozygous, and susceptible (Sus) strains of FAW on different Bt maize and cotton varieties. High survival of strains resistant to the Cry1F (HX-R), Cry1A.105/Cry2Ab (VT-R) and Cry1A.105/Cry2Ab/Cry1F (PW-R) proteins was detected on Herculex, YieldGard VT PRO and PowerCore maize. Our Vip3A-resistant strain (Vip-R) exhibited high survival on Herculex, Agrisure Viptera and Agrisure Viptera 3 maize. However, the heterozygous from HX-R × Sus, VT-R × Sus, PW-R × Sus and Vip-R × Sus had complete mortality on YieldGard VT PRO, PowerCore, Agrisure Viptera, and Agrisure Viptera 3, whereas the HX-R × Sus and Vip-R × Sus strains survived on Herculex maize. On Bt cotton, the HX-R, VT-R and PW-R strains exhibited high survival on Bollgard II. All resistant strains survived on WideStrike, but only PW-R and Vip-R × Sus survived on TwinLink. Our study provides useful data to aid in the understanding of the effectiveness of the refuge strategy for Insect Resistance Management of Bt plants.

  7. Deliberating the perceived risks, benefits, and societal implications of shale gas and oil extraction by hydraulic fracturing in the US and UK

    Science.gov (United States)

    Thomas, Merryn; Partridge, Tristan; Harthorn, Barbara Herr; Pidgeon, Nick

    2017-04-01

    Shale gas and oil production in the US has increased rapidly in the past decade, while interest in prospective development has also arisen in the UK. In both countries, shale resources and the method of their extraction (hydraulic fracturing, or 'fracking') have been met with opposition amid concerns about impacts on water, greenhouse gas emissions, and health effects. Here we report the findings of a qualitative, cross-national deliberation study of public perceptions of shale development in UK and US locations not yet subject to extensive shale development. When presented with a carefully calibrated range of risks and benefits, participants' discourse focused on risks or doubts about benefits, and potential impacts were viewed as inequitably distributed. Participants drew on direct, place-based experiences as well as national contexts in deliberating shale development. These findings suggest that shale gas development already evokes a similar 'signature' of risk across the US and UK.

  8. Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a TBNET/RESIST-TB consensus statement

    NARCIS (Netherlands)

    Domínguez, J.; Boettger, E. C.; Cirillo, D.; Cobelens, F.; Eisenach, K. D.; Gagneux, S.; Hillemann, D.; Horsburgh, R.; Molina-Moya, B.; Niemann, S.; Tortoli, E.; Whitelaw, A.; Lange, C.

    2016-01-01

    The emergence of drug-resistant strains of Mycobacterium tuberculosis is a challenge to global tuberculosis (TB) control. Although culture-based methods have been regarded as the gold standard for drug susceptibility testing (DST), molecular methods provide rapid information on mutations in the M.

  9. Plasmid-Mediated Resistance in Enterobacteriaceae Changing Landscape and Implications for Therapy

    NARCIS (Netherlands)

    Schultsz, Constance; Geerlings, Suzanne

    2012-01-01

    Antimicrobial resistance is increasing worldwide, and pathogenic microorganism's that are resistant to all available antimicrobial agents are increasingly reported. Emerging plasmid-encoded extended-spectrum beta-lactamases (ESBLs) and carbapenemases are increasingly reported worldwide.

  10. Analysis of buffering process of control rod hydraulic absorber

    International Nuclear Information System (INIS)

    Bao Jishi; Qin Benke; Bo Hanliang

    2011-01-01

    Control Rod Hydraulic Drive Mechanism(CRHDM) is a newly invented build-in control rod drive mechanism. Hydraulic absorber is the key part of this mechanism, and is used to cushion the control rod when the rod scrams. Thus, it prevents the control rod from being deformed and damaged. In this paper dynamics program ANSYS CFX is used to calculate all kinds of flow conditions in hydraulic absorber to obtain its hydraulic characteristics. Based on the flow resistance coefficients obtained from the simulation results, fluid mass and momentum equations were developed to get the trend of pressure change in the hydraulic cylinder and the displacement of the piston rod during the buffering process of the control rod. The results obtained in this paper indicate that the hydraulic absorber meets the design requirement. The work in this paper will be helpful for the design and optimization of the control rod hydraulic absorber. (author)

  11. Genetics of Resistance and Pathogenicity in the Maize/Setosphaeria turcica Pathosystem and Implications for Breeding

    Directory of Open Access Journals (Sweden)

    Ana L. Galiano-Carneiro

    2017-08-01

    Full Text Available Northern corn leaf blight (NCLB, the most devastating leaf pathogen in maize (Zea mays L., is caused by the heterothallic ascomycete Setosphaeria turcica. The pathogen population shows an extremely high genetic diversity in tropical and subtropical regions. Varietal resistance is the most efficient technique to control NCLB. Host resistance can be qualitative based on race-specific Ht genes or quantitative controlled by many genes with small effects. Quantitative resistance is moderately to highly effective and should be more durable combatting all races of the pathogen. Quantitative resistance must, however, be analyzed in many environments (= location × year combinations to select stable resistances. In the tropical and subtropical environments, quantitative resistance is the preferred option to manage NCLB epidemics. Resistance level can be increased in practical breeding programs by several recurrent selection cycles based on disease severity rating and/or by genomic selection. This review aims to address two important aspects of the NCLB pathosystem: the genetics of the fungus S. turcica and the modes of inheritance of the host plant maize, including successful breeding strategies regarding NCLB resistance. Both drivers of this pathosystem, pathogen, and host, must be taken into account to result in more durable resistance.

  12. An overview on rod-bundle thermal-hydraulic analyses

    International Nuclear Information System (INIS)

    Sha, W.T.

    1980-01-01

    Three methods used in rod-bundle thermal-hydraulic analysis are summarized. These methods are: (1) subchannel analysis, (2) porous medium formulation with volume porosity, surface permeability, distributed resistance and distributed heat source (sink) and, (3) bench-mark rod-bundle thermal-hydraulic analysis using a boundary-fitted coordinate system. Basic limitations and merits of each method are delineated. (orig.)

  13. Failure analysis of fire resistant fluid (FRF piping used in hydraulic control system at oil-fired thermal power generation plant

    Directory of Open Access Journals (Sweden)

    Muhammad Akram

    2017-04-01

    Full Text Available This is a case study regarding frequent forced outages in an oil-fired power generating station due to failure of fire resistant fluid (FRF piping of material ASTM A-304. This analysis was done to find out the most probable cause of failure and to rectify the problem. Methods for finding and analyzing the cracks include nondestructive testing techniques such as visual testing (VT and dye penetrant testing (PT along with that periodic monitoring after rectification of problem. The study revealed that pitting and pit to crack transitions were formed in stainless steel piping containing high pressure (system pressure 115 bars fire resistant fluid. However, after replacement of piping the pitting and cracking reoccurred. It was observed that due to possible exposure to chlorinated moisture in surrounding environment pitting was formed which then transformed into cracks. The research work discussed in this paper illustrates the procedure used in detection of the problem and measures taken to solve the problem.

  14. Mechanisms of quinolone resistance and implications for human and animal health

    Directory of Open Access Journals (Sweden)

    Velhner Maja

    2010-01-01

    Full Text Available Quinolone antibiotics have been widely used in human and veterinary medicine. This has caused the development of resistance and difficulties in the treatment of complicated bacterial infections in humans. The resistance to quinolones develops due to chromosome mutations and it can also be transferred by plasmids. The target enzyme for quinolones in Gram-negative bacteria is Gyrasa A, while the target enzyme in Grampositive bacteria is mostly topoisomerase IV. Gyrase A consists of two subunits encoded by genes gyrA and gyrB. The function of the enzyme is to introduce negative super coiling in DNA and therefore is essential for the replication of bacteria. Quinolone resistance develops if point mutations at 83 and/or 87 codon are introduced on gyrA. Establishing a minimal inhibitory concentration (MIC to this group of antimicrobials will reveal possible mutations. Recently it was discovered that quinolone resistance is transmittable by plasmid termed PMQR (plasmid mediated quinolone resistance. The target gene marked qnr encodes a pentapeptide repeat family protein. Pentapeptide repeats form sheets, involved in protein-protein interactions. Qnr protein binds to GyrA protecting the enzyme from the inhibitory effect of ciprofloxacin. The distribution of qnr related resistance is higher in humans than in animals. In poultry, however, this type of resistance is present more than in other animals. Plasmid mediated resistance contributes to the faster spread of quinolone resistance. Proper food handling will significantly contribute to decreasing the risk from infection to which people are exposed. In medical and veterinary laboratories antimicrobial resistance monitoring in clinical and environmental isolates is advised. Since correlation between antibiotics application and antimicrobial resistance is often suggested, antimicrobial use must be under strict control of the authorities both in human and in veterinary medicine. .

  15. Effect of exoskeletal joint constraint and passive resistance on metabolic energy expenditure: Implications for walking in paraplegia.

    Directory of Open Access Journals (Sweden)

    Sarah R Chang

    Full Text Available An important consideration in the design of a practical system to restore walking in individuals with spinal cord injury is to minimize metabolic energy demand on the user. In this study, the effects of exoskeletal constraints on metabolic energy expenditure were evaluated in able-bodied volunteers to gain insight into the demands of walking with a hybrid neuroprosthesis after paralysis. The exoskeleton had a hydraulic mechanism to reciprocally couple hip flexion and extension, unlocked hydraulic stance controlled knee mechanisms, and ankles fixed at neutral by ankle-foot orthoses. These mechanisms added passive resistance to the hip (15 Nm and knee (6 Nm joints while the exoskeleton constrained joint motion to the sagittal plane. The average oxygen consumption when walking with the exoskeleton was 22.5 ± 3.4 ml O2/min/kg as compared to 11.7 ± 2.0 ml O2/min/kg when walking without the exoskeleton at a comparable speed. The heart rate and physiological cost index with the exoskeleton were at least 30% and 4.3 times higher, respectively, than walking without it. The maximum average speed achieved with the exoskeleton was 1.2 ± 0.2 m/s, at a cadence of 104 ± 11 steps/min, and step length of 70 ± 7 cm. Average peak hip joint angles (25 ± 7° were within normal range, while average peak knee joint angles (40 ± 8° were less than normal. Both hip and knee angular velocities were reduced with the exoskeleton as compared to normal. While the walking speed achieved with the exoskeleton could be sufficient for community ambulation, metabolic energy expenditure was significantly increased and unsustainable for such activities. This suggests that passive resistance, constraining leg motion to the sagittal plane, reciprocally coupling the hip joints, and weight of exoskeleton place considerable limitations on the utility of the device and need to be minimized in future designs of practical hybrid neuroprostheses for walking after paraplegia.

  16. Antibiotic Use in Agriculture and Its Consequential Resistance in Environmental Sources: Potential Public Health Implications

    Directory of Open Access Journals (Sweden)

    Christy Manyi-Loh

    2018-03-01

    Full Text Available Due to the increased demand of animal protein in developing countries, intensive farming is instigated, which results in antibiotic residues in animal-derived products, and eventually, antibiotic resistance. Antibiotic resistance is of great public health concern because the antibiotic-resistant bacteria associated with the animals may be pathogenic to humans, easily transmitted to humans via food chains, and widely disseminated in the environment via animal wastes. These may cause complicated, untreatable, and prolonged infections in humans, leading to higher healthcare cost and sometimes death. In the said countries, antibiotic resistance is so complex and difficult, due to irrational use of antibiotics both in the clinical and agriculture settings, low socioeconomic status, poor sanitation and hygienic status, as well as that zoonotic bacterial pathogens are not regularly cultured, and their resistance to commonly used antibiotics are scarcely investigated (poor surveillance systems. The challenges that follow are of local, national, regional, and international dimensions, as there are no geographic boundaries to impede the spread of antibiotic resistance. In addition, the information assembled in this study through a thorough review of published findings, emphasized the presence of antibiotics in animal-derived products and the phenomenon of multidrug resistance in environmental samples. This therefore calls for strengthening of regulations that direct antibiotic manufacture, distribution, dispensing, and prescription, hence fostering antibiotic stewardship. Joint collaboration across the world with international bodies is needed to assist the developing countries to implement good surveillance of antibiotic use and antibiotic resistance.

  17. Antibiotic Use in Agriculture and Its Consequential Resistance in Environmental Sources: Potential Public Health Implications.

    Science.gov (United States)

    Manyi-Loh, Christy; Mamphweli, Sampson; Meyer, Edson; Okoh, Anthony

    2018-03-30

    Due to the increased demand of animal protein in developing countries, intensive farming is instigated, which results in antibiotic residues in animal-derived products, and eventually, antibiotic resistance. Antibiotic resistance is of great public health concern because the antibiotic-resistant bacteria associated with the animals may be pathogenic to humans, easily transmitted to humans via food chains, and widely disseminated in the environment via animal wastes. These may cause complicated, untreatable, and prolonged infections in humans, leading to higher healthcare cost and sometimes death. In the said countries, antibiotic resistance is so complex and difficult, due to irrational use of antibiotics both in the clinical and agriculture settings, low socioeconomic status, poor sanitation and hygienic status, as well as that zoonotic bacterial pathogens are not regularly cultured, and their resistance to commonly used antibiotics are scarcely investigated (poor surveillance systems). The challenges that follow are of local, national, regional, and international dimensions, as there are no geographic boundaries to impede the spread of antibiotic resistance. In addition, the information assembled in this study through a thorough review of published findings, emphasized the presence of antibiotics in animal-derived products and the phenomenon of multidrug resistance in environmental samples. This therefore calls for strengthening of regulations that direct antibiotic manufacture, distribution, dispensing, and prescription, hence fostering antibiotic stewardship. Joint collaboration across the world with international bodies is needed to assist the developing countries to implement good surveillance of antibiotic use and antibiotic resistance.

  18. Relationship between weed dormancy and herbicide rotations: implications in resistance evolution.

    Science.gov (United States)

    Darmency, Henri; Colbach, Nathalie; Le Corre, Valérie

    2017-10-01

    It is suggested that selection for late germinating seed cohorts is significantly associated with herbicide resistance in some cropping systems. In turn, it is conceivable that rotating herbicide modes of action selects for populations with mutations for increased secondary dormancy, thus partially overcoming the delaying effect of rotation on resistance evolution. Modified seed dormancy could affect management strategies - like herbicide rotation - that are used to prevent or control herbicide resistance. Here, we review the literature for data on seed dormancy and germination dynamics of herbicide-resistant versus susceptible plants. Few studies use plant material with similar genetic backgrounds, so there are few really comparative data. Increased dormancy and delayed germination may co-occur with resistance to ACCase inhibitors, but there is no clear-cut link with resistance to other herbicide classes. Population shifts are due in part to pleiotropic effects of the resistance genes, but interaction with the cropping system is also possible. We provide an example of a model simulation that accounts for genetic diversity in the dormancy trait, and subsequent consequences for various cropping systems. We strongly recommend adding more accurate and detailed mechanistic modelling to the current tools used today to predict the efficiency of prevention and management of herbicide resistance. These models should be validated through long-term experimental designs including mono-herbicide versus chemical rotation in the field. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  19. Assessing the oseltamivir-induced resistance risk and implications for influenza infection control strategies

    Directory of Open Access Journals (Sweden)

    Hsieh NH

    2017-07-01

    Full Text Available Nan-Hung Hsieh,1 Yi-Jun Lin,2 Ying-Fei Yang,2 Chung-Min Liao2 1Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA; 2Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan Background: Oseltamivir-resistant mutants with higher drug resistance rates and low transmission fitness costs have not accounted for influenza (subtype viruses. Predicting the impacts of neuraminidase inhibitor therapy on infection rates and transmission of drug-resistant viral strains requires further investigation.Objectives: The purpose of this study was to assess the potential risk of oseltamivir-induced resistance for influenza A (H1N1 and A (H3N2 viruses.Materials and methods: An immune-response-based virus dynamic model was used to best fit the oseltamivir-resistant A (H1N1 and A (H3N2 infection data. A probabilistic risk assessment model was developed by incorporating branching process-derived probability distribution of resistance to estimate oseltamivir-induced resistance risk.Results: Mutation rate and sensitive strain number were key determinants in assessing resistance risk. By increasing immune response, antiviral efficacy, and fitness cost, the spread of resistant strains for A (H1N1 and A (H3N2 were greatly decreased. Probability of resistance depends most strongly on the sensitive strain number described by a Poisson model. Risk of oseltamivir-induced resistance increased with increasing the mutation rate for A (H1N1 only. The ≥50% of resistance risk induced by A (H1N1 and A (H3N2 sensitive infected cells were 0.4 (95% CI: 0.28–0.43 and 0.95 (95% CI 0.93–0.99 at a mutation rate of 10−6, respectively. Antiviral drugs must be administrated within 1–1.5 days for A (H1N1 and 2–2.5 days for A (H3N2 virus infections to limit viral production.Conclusion: Probabilistic risk assessment of antiviral drug

  20. Thermally Actuated Hydraulic Pumps

    Science.gov (United States)

    Jones, Jack; Ross, Ronald; Chao, Yi

    2008-01-01

    Thermally actuated hydraulic pumps have been proposed for diverse applications in which direct electrical or mechanical actuation is undesirable and the relative slowness of thermal actuation can be tolerated. The proposed pumps would not contain any sliding (wearing) parts in their compressors and, hence, could have long operational lifetimes. The basic principle of a pump according to the proposal is to utilize the thermal expansion and contraction of a wax or other phase-change material in contact with a hydraulic fluid in a rigid chamber. Heating the chamber and its contents from below to above the melting temperature of the phase-change material would cause the material to expand significantly, thus causing a substantial increase in hydraulic pressure and/or a substantial displacement of hydraulic fluid out of the chamber. Similarly, cooling the chamber and its contents from above to below the melting temperature of the phase-change material would cause the material to contract significantly, thus causing a substantial decrease in hydraulic pressure and/or a substantial displacement of hydraulic fluid into the chamber. The displacement of the hydraulic fluid could be used to drive a piston. The figure illustrates a simple example of a hydraulic jack driven by a thermally actuated hydraulic pump. The pump chamber would be a cylinder containing encapsulated wax pellets and containing radial fins to facilitate transfer of heat to and from the wax. The plastic encapsulation would serve as an oil/wax barrier and the remaining interior space could be filled with hydraulic oil. A filter would retain the encapsulated wax particles in the pump chamber while allowing the hydraulic oil to flow into and out of the chamber. In one important class of potential applications, thermally actuated hydraulic pumps, exploiting vertical ocean temperature gradients for heating and cooling as needed, would be used to vary hydraulic pressures to control buoyancy in undersea research

  1. Implications of Antibiotic Resistance in the Management of Helicobacter pylori Infection: Canadian Helicobacter Study Group

    Directory of Open Access Journals (Sweden)

    RH Hunt

    2000-01-01

    Full Text Available Eradication of Helicobacter pylori from the gastric and duodenal mucosa is an important clinical goal in the treatment of infected patients with peptic ulcer disease and other H pylori-associated conditions. Although several oral drug combination regimens are associated with eradication rates of approximately 85% in controlled trials, the success rate in patients infected with a resistant strain of H pylori is closer to 75%. Resistance to metronidazole and clarithromycin, which are common components of combination treatment regimens, is of greatest concern. Reported rates of H pylori resistance to various antibiotics vary considerably. In Canada, the data documenting H pylori susceptibility are limited but suggest that resistance to these antibiotics varies geographically and within specific treatment groups. Although susceptibility testing is not a prerequisite for initial treatment of individual patients infected with H pylori, formal efforts to identify and monitor both the causes and prevalence of antibiotic resistance across Canada are a much needed step in the ongoing management of this important infection. Recommended treatment regimens may be useful, even for treating apparently resistant H pylori strains. However, it is important to understand the mechanisms of the development of resistant strains to manage patients with treatment failure better.

  2. Specific storage and hydraulic conductivity tomography through the joint inversion of hydraulic heads and self-potential data

    Science.gov (United States)

    Ahmed, A. Soueid; Jardani, A.; Revil, A.; Dupont, J. P.

    2016-03-01

    Transient hydraulic tomography is used to image the heterogeneous hydraulic conductivity and specific storage fields of shallow aquifers using time series of hydraulic head data. Such ill-posed and non-unique inverse problem can be regularized using some spatial geostatistical characteristic of the two fields. In addition to hydraulic heads changes, the flow of water, during pumping tests, generates an electrical field of electrokinetic nature. These electrical field fluctuations can be passively recorded at the ground surface using a network of non-polarizing electrodes connected to a high impedance (> 10 MOhm) and sensitive (0.1 mV) voltmeter, a method known in geophysics as the self-potential method. We perform a joint inversion of the self-potential and hydraulic head data to image the hydraulic conductivity and specific storage fields. We work on a 3D synthetic confined aquifer and we use the adjoint state method to compute the sensitivities of the hydraulic parameters to the hydraulic head and self-potential data in both steady-state and transient conditions. The inverse problem is solved using the geostatistical quasi-linear algorithm framework of Kitanidis. When the number of piezometers is small, the record of the transient self-potential signals provides useful information to characterize the hydraulic conductivity and specific storage fields. These results show that the self-potential method reveals the heterogeneities of some areas of the aquifer, which could not been captured by the tomography based on the hydraulic heads alone. In our analysis, the improvement on the hydraulic conductivity and specific storage estimations were based on perfect knowledge of electrical resistivity field. This implies that electrical resistivity will need to be jointly inverted with the hydraulic parameters in future studies and the impact of its uncertainty assessed with respect to the final tomograms of the hydraulic parameters.

  3. Digital switched hydraulics

    Science.gov (United States)

    Pan, Min; Plummer, Andrew

    2018-06-01

    This paper reviews recent developments in digital switched hydraulics particularly the switched inertance hydraulic systems (SIHSs). The performance of SIHSs is presented in brief with a discussion of several possible configurations and control strategies. The soft switching technology and high-speed switching valve design techniques are discussed. Challenges and recommendations are given based on the current research achievements.

  4. Hydraulic Structures : Caissons

    NARCIS (Netherlands)

    Voorendt, M.Z.; Molenaar, W.F.; Bezuyen, K.G.

    These lecture notes on caissons are part of the study material belonging to the course 'Hydraulic Structures 1' (code CTB3355), part of the Bachelor of Science education and the Hydraulic Engineering track of the Master of Science education for civil engineering students at Delft University of

  5. Hydraulic Shearing and Hydraulic Jacking Observed during Hydraulic Stimulations in Fractured Geothermal Reservoir in Pohang, Korea

    Science.gov (United States)

    Min, K. B.; Park, S.; Xie, L.; Kim, K. I.; Yoo, H.; Kim, K. Y.; Choi, J.; Yoon, K. S.; Yoon, W. S.; Lee, T. J.; Song, Y.

    2017-12-01

    Enhanced Geothermal System (EGS) relies on sufficient and irreversible enhancement of reservoir permeability through hydraulic stimulation and possibility of such desirable change of permeability is an open question that can undermine the universality of EGS concept. We report results of first hydraulic stimulation campaign conducted in two deep boreholes in fractured granodiorite geothermal reservoir in Pohang, Korea. Borehole PX-1, located at 4.22 km, was subjected to the injection of 3,907 m3 with flow rate of up to 18 kg/s followed by bleeding off of 1,207 m3. The borehole PX-2, located at 4.35 km, was subjected to the injection of 1,970 m3 with flow rate of up to 46 kg/sIn PX-1, a sharp distinct decline of wellhead pressure was observed at around 16 MPa of wellhead pressure which was similar to the predicted injection pressure to induce hydraulic shearing. Injectivity interpretation before and after the hydraulic shearing indicates that permanent increase of permeability was achieved by a factor of a few. In PX-2, however, injectivity was very small and hydraulic shearing was not observed due possibly to the near wellbore damage made by the remedying process of lost circulation such as using lost circulation material during drilling. Flow rate of larger than 40 kg/s was achieved at very high well head pressure of nearly 90 MPa. Hydraulic jacking, that is reversible opening and closure of fracture with change of injection pressure, was clearly observed. Although sharp increase of permeability due to fracture opening was achieved with elevated injection pressure, the increased permeability was reversed with decreased injection pressure.Two contrasting response observed in the same reservoir at two different boreholes which is apart only 600 m apart provide important implication that can be used for the stimulation strategy for EGS.This work was supported by the New and Renewable Energy Technology Development Program of the Korea Institute of Energy Technology

  6. Vibration of hydraulic machinery

    CERN Document Server

    Wu, Yulin; Liu, Shuhong; Dou, Hua-Shu; Qian, Zhongdong

    2013-01-01

    Vibration of Hydraulic Machinery deals with the vibration problem which has significant influence on the safety and reliable operation of hydraulic machinery. It provides new achievements and the latest developments in these areas, even in the basic areas of this subject. The present book covers the fundamentals of mechanical vibration and rotordynamics as well as their main numerical models and analysis methods for the vibration prediction. The mechanical and hydraulic excitations to the vibration are analyzed, and the pressure fluctuations induced by the unsteady turbulent flow is predicted in order to obtain the unsteady loads. This book also discusses the loads, constraint conditions and the elastic and damping characters of the mechanical system, the structure dynamic analysis, the rotor dynamic analysis and the system instability of hydraulic machines, including the illustration of monitoring system for the instability and the vibration in hydraulic units. All the problems are necessary for vibration pr...

  7. Handbook of hydraulic fluid technology

    CERN Document Server

    Totten, George E

    2011-01-01

    ""The Handbook of Hydraulic Fluid Technology"" serves as the foremost resource for designing hydraulic systems and for selecting hydraulic fluids used in engineering applications. Featuring new illustrations, data tables, as well as practical examples, this second edition is updated with essential information on the latest hydraulic fluids and testing methods. The detailed text facilitates unparalleled understanding of the total hydraulic system, including important hardware, fluid properties, and hydraulic lubricants. Written by worldwide experts, the book also offers a rigorous overview of h

  8. Artemisinin-resistant malaria: research challenges, opportunities, and public health implications.

    Science.gov (United States)

    Fairhurst, Rick M; Nayyar, Gaurvika M L; Breman, Joel G; Hallett, Rachel; Vennerstrom, Jonathan L; Duong, Socheat; Ringwald, Pascal; Wellems, Thomas E; Plowe, Christopher V; Dondorp, Arjen M

    2012-08-01

    Artemisinin-based combination therapies are the most effective drugs to treat Plasmodium falciparum malaria. Reduced sensitivity to artemisinin monotherapy, coupled with the emergence of parasite resistance to all partner drugs, threaten to place millions of patients at risk of inadequate treatment of malaria. Recognizing the significance and immediacy of this possibility, the Fogarty International Center and the National Institute of Allergy and Infectious Diseases of the U.S. National Institutes of Health convened a conference in November 2010 to bring together the diverse array of stakeholders responding to the growing threat of artemisinin resistance, including scientists from malarious countries in peril. This conference encouraged and enabled experts to share their recent unpublished data from studies that may improve our understanding of artemisinin resistance. Conference sessions addressed research priorities to forestall artemisinin resistance and fostered collaborations between field- and laboratory-based researchers and international programs, with the aim of translating new scientific evidence into public health solutions. Inspired by this conference, this review summarizes novel findings and perspectives on artemisinin resistance, approaches for translating research data into relevant public health information, and opportunities for interdisciplinary collaboration to combat artemisinin resistance.

  9. Antibiotic resistance of canine Staphylococcus intermedius group (SIG)--practical implications.

    Science.gov (United States)

    Chrobak, D; Kizerwetter-Swida, M; Rzewuska, M; Binek, M

    2011-01-01

    A total of 221 SIG strains were isolated from clinical samples of canine origin submitted to the Diagnostic Laboratory of the Division of Bacteriology and Molecular Biology at the Warsaw University of Life Sciences in Warsaw during the period 2006-2010. The aim of the study was to investigate the frequency of prevalence of methicillin-resistant SIG strains and to determine the MIC values of cephalotin, amoxicillin/clavulanic acid, ciprofloxacin, clindamycin, gentamicin, chloramphenicol, mupirocin for a collection of randomly selected 79 strains belonging to Staphylococcus intermedius group (SIG), including 23 mecA-positive and 56 mecA-negative strains. All isolates were identified as belonging to SIG based on their phenotypic properties and PCR amplification of S. intermedius-specific fragment of the 16S rRNA gene. The mecA gene was detected in 26 (12%) of 221 SIG strains. All tested mecA-negative SIG strains were susceptible to amoxicillin/clavulanic acid and cephalotin. One of the 56 mecA-negative SIG strains was resistant to ciprofloxacin, six (11%) to gentamicin. It was found that sixteen (29%) of 56 mecA-negative SIG strains were resistant to clindamycin. Most of the mecA-positive SIG strains were resistant to ciprofloxacin (96%), clindamycin (96%), and gentamicin (96%). Only one MRSIG strain was resistant to chloramphenicol. All examined mecA-positive SIG strains were found to be susceptible to mupirocin. Our results imply that staphylococcal multidrug resistance has become more prevalent, which could lead to difficulties in effective treatment. With some resistant strains the only therapeutic possibility are antimicrobial agents important in human medicine. New regulations for veterinary medicine concerning appropriate therapy of infections caused by multidrug-resistat staphylococci are needed.

  10. Spread of anti-malarial drug resistance: Mathematical model with implications for ACT drug policies

    Directory of Open Access Journals (Sweden)

    Dondorp Arjen M

    2008-11-01

    Full Text Available Abstract Background Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT. The impact of different drug choices and implementation strategies is uncertain. Data from many epidemiological studies in different levels of malaria endemicity and in areas with the highest prevalence of drug resistance like borders of Thailand are certainly valuable. Formulating an appropriate dynamic data-driven model is a powerful predictive tool for exploring the impact of these strategies quantitatively. Methods A comprehensive model was constructed incorporating important epidemiological and biological factors of human, mosquito, parasite and treatment. The iterative process of developing the model, identifying data needed, and parameterization has been taken to strongly link the model to the empirical evidence. The model provides quantitative measures of outcomes, such as malaria prevalence/incidence and treatment failure, and illustrates the spread of resistance in low and high transmission settings. The model was used to evaluate different anti-malarial policy options focusing on ACT deployment. Results The model predicts robustly that in low transmission settings drug resistance spreads faster than in high transmission settings, and treatment failure is the main force driving the spread of drug resistance. In low transmission settings, ACT slows the spread of drug resistance to a partner drug, especially at high coverage rates. This effect decreases exponentially with increasing delay in deploying the ACT and decreasing rates of coverage. In the high transmission settings, however, drug resistance is driven by the proportion of the human population with a residual drug level, which gives resistant parasites some survival advantage. The spread of drug resistance could be slowed down by controlling presumptive drug use and avoiding the use of combination therapies containing drugs with

  11. Implication of low level inflammation in the insulin resistance of adipose tissue at late pregnancy.

    Science.gov (United States)

    de Castro, J; Sevillano, J; Marciniak, J; Rodriguez, R; González-Martín, C; Viana, M; Eun-suk, O H; de Mouzon, S Hauguel; Herrera, E; Ramos, M P

    2011-11-01

    Insulin resistance is a characteristic of late pregnancy, and adipose tissue is one of the tissues that most actively contributes to the reduced maternal insulin sensitivity. There is evidence that pregnancy is a condition of moderate inflammation, although the physiological role of this low-grade inflammation remains unclear. The present study was designed to validate whether low-grade inflammation plays a role in the development of insulin resistance in adipose tissue during late pregnancy. To this end, we analyzed proinflammatory adipokines and kinases in lumbar adipose tissue of nonpregnant and late pregnant rats at d 18 and 20 of gestation. We found that circulating and tissue levels of adipokines, such as IL-1β, plasminogen activator inhibitor-1, and TNF-α, were increased at late pregnancy, which correlated with insulin resistance. The observed increase in adipokines coincided with an enhanced activation of p38 MAPK in adipose tissue. Treatment of pregnant rats with the p38 MAPK inhibitor SB 202190 increased insulin-stimulated tyrosine phosphorylation of the insulin receptor (IR) and IR substrate-1 in adipose tissue, which was paralleled by a reduction of IR substrate-1 serine phosphorylation and an enhancement of the metabolic actions of insulin. These results indicate that activation of p38 MAPK in adipose tissue contributes to adipose tissue insulin resistance at late pregnancy. Furthermore, the results of the present study support the hypothesis that physiological low-grade inflammation in the maternal organism is relevant to the development of pregnancy-associated insulin resistance.

  12. Slip resistance of casual footwear: implications for falls in older adults.

    Science.gov (United States)

    Menz, H B; Lord, S T; McIntosh, A S

    2001-01-01

    A large proportion of falls in older people are caused by slipping. Previous occupational safety research suggests that inadequate footwear may contribute to slipping accidents; however, no studies have assessed the slip resistance of casual footwear. To evaluate the slip resistance of different types of casual footwear over a range of common household surfaces. The slip resistance of men's Oxford shoes and women's fashion shoes with different heel configurations was determined by measuring the dynamic coefficient of friction (DCoF) at heel contact (in both dry and wet conditions) on a bathroom tile, concrete, vinyl flooring and a terra cotta tile using a specially-designed piezoelectric force plate apparatus. Analysis of variance revealed significant shoe, surface, and shoe-surface interaction effects. Men's Oxford shoes exhibited higher average DCoF values than the women's fashion shoes, however, none of the shoes could be considered safe on wet surfaces. Application of a textured sole material did not improve slip resistance of any of the shoes on wet surfaces. Heel geometry influences the slip resistance of casual footwear on common household surfaces. The suboptimal performance of all of the test shoes on wet surfaces suggests that a safety standard for casual footwear is required to assist in the development of safe footwear for older people. Copyright 2001 S. Karger AG, Basel

  13. The role of grain size in He bubble formation: Implications for swelling resistance

    Science.gov (United States)

    El-Atwani, O.; Nathaniel, J. E.; Leff, A. C.; Muntifering, B. R.; Baldwin, J. K.; Hattar, K.; Taheri, M. L.

    2017-02-01

    Nanocrystalline metals are postulated as radiation resistant materials due to their high defect and particle (e.g. Helium) sink density. Here, the performance of nanocrystalline iron films is investigated in-situ in a transmission electron microscope (TEM) using He irradiation at 700 K. Automated crystal orientation mapping is used in concert with in-situ TEM to explore the role of grain orientation and grain boundary character on bubble density trends. Bubble density as a function of three key grain size regimes is demonstrated. While the overall trend revealed an increase in bubble density up to a saturation value, grains with areas ranging from 3000 to 7500 nm2 show a scattered distribution. An extrapolated swelling resistance based on bubble size and areal density indicated that grains with sizes less than 2000 nm2 possess the greatest apparent resistance. Moreover, denuded zones are found to be independent of grain size, grain orientation, and grain boundary misorientation angle.

  14. The structure of FIV reverse transcriptase and its implications for non-nucleoside inhibitor resistance.

    Directory of Open Access Journals (Sweden)

    Meytal Galilee

    2018-01-01

    Full Text Available Reverse transcriptase (RT is the target for the majority of anti-HIV-1 drugs. As with all anti-AIDS treatments, continued success of RT inhibitors is persistently disrupted by the occurrence of resistance mutations. To explore latent resistance mechanisms potentially accessible to therapeutically challenged HIV-1 viruses, we examined RT from the related feline immunodeficiency virus (FIV. FIV closely parallels HIV-1 in its replication and pathogenicity, however, is resistant to all non-nucleoside inhibitors (NNRTI. The intrinsic resistance of FIV RT is particularly interesting since FIV harbors the Y181 and Y188 sensitivity residues absent in both HIV-2 and SIV. Unlike RT from HIV-2 or SIV, previous efforts have failed to make FIV RT susceptible to NNRTIs concluding that the structure or flexibility of the feline enzyme must be profoundly different. We report the first crystal structure of FIV RT and, being the first structure of an RT from a non-primate lentivirus, enrich the structural and species repertoires available for RT. The structure demonstrates that while the NNRTI binding pocket is conserved, minor subtleties at the entryway can render the FIV RT pocket more restricted and unfavorable for effective NNRTI binding. Measuring NNRTI binding affinity to FIV RT shows that the "closed" pocket configuration inhibits NNRTI binding. Mutating the loop residues rimming the entryway of FIV RT pocket allows for NNRTI binding, however, it does not confer sensitivity to these inhibitors. This reveals a further layer of resistance caused by inherent FIV RT variances that could have enhanced the dissociation of bound inhibitors, or, perhaps, modulated protein plasticity to overcome inhibitory effects of bound NNRTIs. The more "closed" conformation of FIV RT pocket can provide a template for the development of innovative drugs that could unlock the constrained pocket, and the resilient mutant version of the enzyme can offer a fresh model for the study

  15. Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use.

    Science.gov (United States)

    Bagaglio, Sabrina; Uberti-Foppa, Caterina; Morsica, Giulia

    2017-07-01

    Multiple direct-acting antiviral (DAA)-based regimens are currently approved that provide one or more interferon-free treatment options for hepatitis C virus (HCV) genotypes (G) 1-6. The choice of a DAA regimen, duration of therapy, and use of ribavirin depends on multiple viral and host factors, including HCV genotype, the detection of resistance-associated amino acid (aa) substitutions (RASs), prior treatment experience, and presence of cirrhosis. In regard to viral factors that may guide the treatment choice, the most important is the infecting genotype because a number of DAAs are genotype-designed. The potency and the genetic barrier may also impact the choice of treatment. One important and debated possible virologic factor that may negatively influence the response to DAAs is the presence of baseline RASs. Baseline resistance testing is currently not routinely considered or recommended for initiating HCV treatment, due to the overall high response rates (sustained virological response >90%) obtained. Exceptions are patients infected by HCV G1a when initiating treatment with simeprevir and elbasvir/grazoprevir or in those with cirrhosis prior to daclatasvir/sofosbuvir treatment because of natural polymorphisms demonstrated in sites of resistance. On the basis of these observations, first-line strategies should be optimized to overcome treatment failure due to HCV resistance.

  16. Reducing Resistance to Diversity through Cognitive Dissonance Instruction: Implications for Teacher Education.

    Science.gov (United States)

    McFalls, Elisabeth L.; Cobb-Roberts, Deirdre

    2001-01-01

    Applied the principals of cognitive dissonance theory to an instructional strategy used to reduce resistance to the idea of white privilege, comparing groups of college students in diversity education courses that did and did not receive supplemental instruction on cognitive dissonance. Incorporating cognitive dissonance theory created an…

  17. A Review of ERCC1 Gene in Bladder Cancer: Implications for Carcinogenesis and Resistance to Chemoradiotherapy

    Directory of Open Access Journals (Sweden)

    Atsunari Kawashima

    2012-01-01

    Full Text Available The excision repair cross-complementing group 1 (ERCC1 gene performs a critical incision step in DNA repair and is reported to be correlated with carcinogenesis and resistance to drug or ionizing radiation therapy. We reviewed the correlation between ERCC1 and bladder cancer. In carcinogenesis, several reports discussed the relation between ERCC1 single nucleotide polymorphisms and carcinogenesis in bladder cancer only in case-control studies. Regarding the relation between ERCC1 and resistance to chemoradiotherapy, in vitro and clinical studies indicate that ERCC1 might be related to resistance to radiation therapy rather than cisplatin therapy. It is controversial whether ERCC1 predicts prognosis of bladder cancer treated with cisplatin-based chemotherapy. Tyrosine kinase receptors or endothelial-mesenchymal transition are reported to regulate the expression of ERCC1, and further study is needed to clarify the mechanism of ERCC1 expression and resistance to chemoradiotherapy in vitro and to discover novel therapies for advanced and metastatic bladder cancer.

  18. A Review of ERCC1 Gene in Bladder Cancer: Implications for Carcinogenesis and Resistance to Chemoradiotherapy.

    Science.gov (United States)

    Kawashima, Atsunari; Takayama, Hitoshi; Tsujimura, Akira

    2012-01-01

    The excision repair cross-complementing group 1 (ERCC1) gene performs a critical incision step in DNA repair and is reported to be correlated with carcinogenesis and resistance to drug or ionizing radiation therapy. We reviewed the correlation between ERCC1 and bladder cancer. In carcinogenesis, several reports discussed the relation between ERCC1 single nucleotide polymorphisms and carcinogenesis in bladder cancer only in case-control studies. Regarding the relation between ERCC1 and resistance to chemoradiotherapy, in vitro and clinical studies indicate that ERCC1 might be related to resistance to radiation therapy rather than cisplatin therapy. It is controversial whether ERCC1 predicts prognosis of bladder cancer treated with cisplatin-based chemotherapy. Tyrosine kinase receptors or endothelial-mesenchymal transition are reported to regulate the expression of ERCC1, and further study is needed to clarify the mechanism of ERCC1 expression and resistance to chemoradiotherapy in vitro and to discover novel therapies for advanced and metastatic bladder cancer.

  19. Rust resistance in seedling families of Pinus albicaulis and Pinus strobiformis and implications for restoration

    Science.gov (United States)

    R. A. Sniezko; A. Kegley; R. Danchok; J. Hamlin; J. Hill; D. Conklin

    2011-01-01

    Infection and mortality levels from Cronartium ribicola, the fungus causing white pine blister rust, are very high in parts of the geographic range of Pinus albicaulis (whitebark pine) and P. strobiformis (Southwestern white pine). Genetic resistance to this non-native fungus will be one of the key factors in maintaining or restoring populations of these species in...

  20. High-Current Bus Splice Resistances and Implications for the Operating Energy of the LHC

    CERN Document Server

    Koratzinos, M; Charifoulline, Z; Dahlerup-Petersen, K; Denz, R; Flora, R H; Pfeffer, H; Scheuerlein, C; Schmidt, R; Siemko, A; Strait, J; Verweij, A

    2010-01-01

    At each interconnection between LHC main magnets a low-resistance solder joint must be made between superconducting cables in order to provide a continuous current path through the superconductor and also to the surrounding copper stabilizer in case the cable quenches [1]. About 10,000 such joints exist in the LHC. An extensive campaign has been undertaken to characterize and map the resistances of these joints. All of the superconducting cable splices were measured at 1.9 K and no splices were found with a resistance larger than 3 nW. Non-invasive measurements of the stabilizer joints were made at 300 K in 5 of the 8 sectors, and at 80 K in 3 sectors. More precise local measurements were made on suspect interconnects that were opened up, and poor joints were repaired. However, it is likely that additional imperfect stabilizer joints still exist in the LHC. A statistical analysis is used to place bounds on the remaining worst-case resistances. This sets limits on the maximum operating energy of the LHC, prior...

  1. Detection of Antibiotic Resistant Staphylococcus aureus from Milk: A Public Health Implication

    Science.gov (United States)

    Akindolire, Muyiwa Ajoke; Babalola, Olubukola Oluranti; Ateba, Collins Njie

    2015-01-01

    The aim of this study was to investigate the occurrence, antibiotic susceptibility profiles, and virulence genes determinants of S. aureus isolated from milk obtained from retail outlets of the North-West Province, South Africa. To achieve this, 200 samples of raw, bulk and pasteurised milk were obtained randomly from supermarkets, shops and some farms in the North-West Province between May 2012 and April 2013. S. aureus was isolated and positively identified using morphological (Gram staining), biochemical (DNase, catalase, haemolysis and rapid slide agglutination) tests, protein profile analysis (MALDI-TOF mass spectrometry) and molecular (nuc specific PCR) methods. The antimicrobial resistance profiles of the isolates were determined using the phenotypic agar diffusion method. Genes encoding enterotoxins, exfoliative toxins and collagen adhesins were also screened using PCR. Among all the samples examined, 30 of 40 raw milk samples (75%), 25 of 85 bulk milk samples (29%) and 10 of 75 pasteurised milk samples (13%) were positive for S. aureus. One hundred and fifty-six PCR-confirmed S. aureus isolates were obtained from 75 contaminated milk samples. A large proportion (60%–100%) of the isolates was resistant to penicillin G, ampicillin, oxacillin, vancomycin, teicoplanin and erythromycin. On the contrary, low level resistance (8.3%–40%) was observed for gentamicin, kanamycin and sulphamethoxazole. Methicillin resistance was detected in 59% of the multidrug resistant isolates and this was a cause for concern. However, only a small proportion (20.6%) of these isolates possessed PBP2a which codes for Methicillin resistance in S. aureus. In addition, 32.7% of isolates possessed the sec gene whereas the sea, seb sed, see, cna, eta, etb genes were not detected. The findings of this study showed that raw, bulk and pasteurised milk in the North-West Province is contaminated with toxigenic and multi-drug resistant S. aureus strains. There is a need to implement

  2. Hydraulic Yaw System

    DEFF Research Database (Denmark)

    Stubkier, Søren; Pedersen, Henrik C.; Mørkholt, M.

    a hydraulic soft yaw system, which is able to reduce the loads on the wind turbine significantly. A full scale hydraulic yaw test rig is available for experiments and tests. The test rig is presented as well as the system schematics of the hydraulic yaw system....... the HAWC2 aeroelastic code and an extended model of the NREL 5MW turbine combined with a simplified linear model of the turbine, the parameters of the soft yaw system are optimized to reduce loading in critical components. Results shows that a significant reduction in fatigue and extreme loads to the yaw...... system and rotor shaft when utilizing the soft yaw drive concept compared to the original stiff yaw system. The physical demands of the hydraulic yaw system are furthermore examined for a life time of 20 years. Based on the extrapolated loads, the duty cycles show that it is possible to construct...

  3. Water Hydraulic Systems

    DEFF Research Database (Denmark)

    Conrad, Finn

    2005-01-01

    The paper presents research results using IT-Tools for CAD and dynamic modelling, simulation, analysis, and design of water hydraulic actuators for motion control of machines, lifts, cranes and robots. Matlab/Simulink and CATIA are used as IT-Tools. The contributions include results from on......-going research projects on fluid power and mechatronics based on tap water hydraulic servovalves and linear servo actuators and rotary vane actuators for motion control and power transmission. Development and design a novel water hydraulic rotary vane actuator for robot manipulators. Proposed mathematical...... modelling, control and simulation of a water hydraulic rotary vane actuator applied to power and control a two-links manipulator and evaluate performance. The results include engineering design and test of the proposed simulation models compared with IHA Tampere University’s presentation of research...

  4. Hydraulic hoisting and backfilling

    Science.gov (United States)

    Sauermann, H. B.

    In a country such as South Africa, with its large deep level mining industry, improvements in mining and hoisting techniques could result in substantial savings. Hoisting techniques, for example, may be improved by the introduction of hydraulic hoisting. The following are some of the advantages of hydraulic hoisting as against conventional skip hoisting: (1) smaller shafts are required because the pipes to hoist the same quantity of ore hydraulically require less space in the shaft than does skip hoisting equipment; (2) the hoisting capacity of a mine can easily be increased without the necessity of sinking new shafts. Large savings in capital costs can thus be made; (3) fully automatic control is possible with hydraulic hoisting and therefore less manpower is required; and (4) health and safety conditions will be improved.

  5. Resilience and resistance of sagebrush ecosystems: implications for state and transition models and management treatments

    Science.gov (United States)

    Chambers, Jeanne C.; Miller, Richard F.; Board, David I.; Pyke, David A.; Roundy, Bruce A.; Grace, James B.; Schupp, Eugene W.; Tausch, Robin J.

    2014-01-01

    In sagebrush ecosystems invasion of annual exotics and expansion of piñon (Pinus monophylla Torr. and Frem.) and juniper (Juniperus occidentalis Hook., J. osteosperma [Torr.] Little) are altering fire regimes and resulting in large-scale ecosystem transformations. Management treatments aim to increase resilience to disturbance and enhance resistance to invasive species by reducing woody fuels and increasing native perennial herbaceous species. We used Sagebrush Steppe Treatment Evaluation Project data to test predictions on effects of fire vs. mechanical treatments on resilience and resistance for three site types exhibiting cheatgrass (Bromus tectorum L.) invasion and/or piñon and juniper expansion: 1) warm and dry Wyoming big sagebrush (WY shrub); 2) warm and moist Wyoming big sagebrush (WY PJ); and 3) cool and moist mountain big sagebrush (Mtn PJ). Warm and dry (mesic/aridic) WY shrub sites had lower resilience to fire (less shrub recruitment and native perennial herbaceous response) than cooler and moister (frigid/xeric) WY PJ and Mtn PJ sites. Warm (mesic) WY Shrub and WY PJ sites had lower resistance to annual exotics than cool (frigid to cool frigid) Mtn PJ sites. In WY shrub, fire and sagebrush mowing had similar effects on shrub cover and, thus, on perennial native herbaceous and exotic cover. In WY PJ and Mtn PJ, effects were greater for fire than cut-and-leave treatments and with high tree cover in general because most woody vegetation was removed increasing resources for other functional groups. In WY shrub, about 20% pretreatment perennial native herb cover was necessary to prevent increases in exotics after treatment. Cooler and moister WY PJ and especially Mtn PJ were more resistant to annual exotics, but perennial native herb cover was still required for site recovery. We use our results to develop state and transition models that illustrate how resilience and resistance influence vegetation dynamics and management options.

  6. Detection of Methicillin-Resistant Staphylococci Isolated from Food Producing Animals: A Public Health Implication

    Directory of Open Access Journals (Sweden)

    Etinosa O. Igbinosa

    2016-07-01

    Full Text Available The emergence of antibiotic-resistant bacteria in food animals is a potential public health concern. Staphylococci are a significant opportunistic pathogen both in humans and dairy cattle. In the present study, the genotypic characterization of methicillin-resistant staphylococcal strains recovered from dairy cattle in a rural community (Okada, Edo State, Nigeria was investigated. A total of 283 samples from cattle (137 milk samples and 146 nasal swabs were assessed between February and April 2015. Antimicrobial susceptibility was performed by Kirby-Bauer disc diffusion method. Polymerase chain reaction (PCR assay was employed for the detection of 16S rRNA, mecA and Panton-Valentine Leucocidinis (PVL genes. The staphylococcal strains were identified through partial 16S ribosomal ribonucleic acids (rRNA nucleotide sequencing, and Basic Local Alignment Search Tool (BLAST analysis of the gene sequence showed that the staphylococcal strains have 96%–100% similarity to Staphylococcus aureus (30, S. epidermidis (17, S. haemolyticus (15, S. saprophyticus (13, S. chromogenes (8, S. simulans (7, S. pseudintermedius (6 and S. xylosus (4. Resistance of 100% was observed in all Staphylococcus spp. against MET, PEN, CLN, CHL and SXT. Multi-drug resistant (MDR bacteria from nasal cavities and raw milk reveals 13 isolates were MDR against METR, PENR, AMXR, CLNR, CHLR, SXTR CLXR, KANR, ERYR, and VANR. Of all isolates, 100% harboured the mecA gene, while 30% of the isolates possess the PVL gene. All S. aureus harboured the PVL gene while other Staphylococcus spp. were negative for the PVL gene. The presence of methicillin-resistant Staphylococcus spp. isolates in dairy cattle is a potential public health risk and thus findings in this study can be used as a baseline for further surveillance.

  7. Monitoring Antimicrobial Resistance in the Food Supply Chain and Its Implications for FDA Policy Initiatives.

    Science.gov (United States)

    Zawack, Kelson; Li, Min; Booth, James G; Love, Will; Lanzas, Cristina; Gröhn, Yrjö T

    2016-09-01

    In response to concerning increases in antimicrobial resistance (AMR), the Food and Drug Administration (FDA) has decided to increase veterinary oversight requirements for antimicrobials and restrict their use in growth promotion. Given the high stakes of this policy for the food supply, economy, and human and veterinary health, it is important to rigorously assess the effects of this policy. We have undertaken a detailed analysis of data provided by the National Antimicrobial Resistance Monitoring System (NARMS). We examined the trends in both AMR proportion and MIC between 2004 and 2012 at slaughter and retail stages. We investigated the makeup of variation in these data and estimated the sample and effect size requirements necessary to distinguish an effect of the policy change. Finally, we applied our approach to take a detailed look at the 2005 withdrawal of approval for the fluoroquinolone enrofloxacin in poultry water. Slaughter and retail showed similar trends. Both AMR proportion and MIC were valuable in assessing AMR, capturing different information. Most variation was within years, not between years, and accounting for geographic location explained little additional variation. At current rates of data collection, a 1-fold change in MIC should be detectable in 5 years and a 6% decrease in percent resistance could be detected in 6 years following establishment of a new resistance rate. Analysis of the enrofloxacin policy change showed the complexities of the AMR policy with no statistically significant change in resistance of both Campylobacter jejuni and Campylobacter coli to ciprofloxacin, another second-generation fluoroquinolone. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  8. The hydraulic wheel

    International Nuclear Information System (INIS)

    Alvarez Cardona, A.

    1985-01-01

    The present article this dedicated to recover a technology that key in disuse for the appearance of other techniques. It is the hydraulic wheel with their multiple possibilities to use their energy mechanical rotational in direct form or to generate electricity directly in the fields in the place and to avoid the high cost of transport and transformation. The basic theory is described that consists in: the power of the currents of water and the hydraulic receivers. The power of the currents is determined knowing the flow and east knowing the section of the flow and its speed; they are given you formulate to know these and direct mensuration methods by means of floodgates, drains and jumps of water. The hydraulic receivers or properly this hydraulic wheels that are the machines in those that the water acts like main force and they are designed to transmit the biggest proportion possible of absolute work of the water, the hydraulic wheels of horizontal axis are the common and they are divided in: you rotate with water for under, you rotate with side water and wheels with water for above. It is analyzed each one of them, their components are described; the conditions that should complete to produce a certain power and formulate them to calculate it. There are 25 descriptive figures of the different hydraulic wheels

  9. Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications

    Science.gov (United States)

    Diamanti-Kandarakis, Evanthia

    2012-01-01

    Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected women have marked insulin resistance, independent of obesity. This article summarizes the state of the science since we last reviewed the field in the Endocrine Reviews in 1997. There is general agreement that obese women with PCOS are insulin resistant, but some groups of lean affected women may have normal insulin sensitivity. There is a post-binding defect in receptor signaling likely due to increased receptor and insulin receptor substrate-1 serine phosphorylation that selectively affects metabolic but not mitogenic pathways in classic insulin target tissues and in the ovary. Constitutive activation of serine kinases in the MAPK-ERK pathway may contribute to resistance to insulin's metabolic actions in skeletal muscle. Insulin functions as a co-gonadotropin through its cognate receptor to modulate ovarian steroidogenesis. Genetic disruption of insulin signaling in the brain has indicated that this pathway is important for ovulation and body weight regulation. These insights have been directly translated into a novel therapy for PCOS with insulin-sensitizing drugs. Furthermore, androgens contribute to insulin resistance in PCOS. PCOS may also have developmental origins due to androgen exposure at critical periods or to intrauterine growth restriction. PCOS is a complex genetic disease, and first-degree relatives have reproductive and metabolic phenotypes. Several PCOS genetic susceptibility loci have been mapped and replicated. Some of the same susceptibility genes contribute to disease risk in Chinese and European PCOS populations, suggesting that PCOS is an ancient trait. PMID:23065822

  10. Implication of inflammatory signaling pathways in obesity-induced insulin resistance

    Directory of Open Access Journals (Sweden)

    Jean-François eTANTI

    2013-01-01

    Full Text Available Obesity is characterized by the development of a low-grade chronic inflammatory state in different metabolic tissues including adipose tissue and liver. This inflammation develops in response to an excess of nutrient flux and is now recognized as an important link between obesity and insulin resistance. Several dietary factors like saturated fatty acids and glucose as well as changes in gut microbiota have been proposed as triggers of this metabolic inflammation through the activation of pattern-recognition receptors, including Toll-like receptors, inflammasome and NOD. The consequences are the production of pro-inflammatory cytokines and the recruitment of immune cells such as macrophages and T lymphocytes in metabolic tissues. Inflammatory cytokines activate several kinases like IKKbeta, mTOR/S6 kinase and MAP kinases as well as SOCS proteins that interfere with insulin signaling and action in adipocytes and hepatocytes. In this review, we summarize recent studies demonstrating that pattern recognition receptors and stress kinases are important integrators of metabolic and inflammatory stress signals in metabolic tissues leading to peripheral and central insulin resistance and metabolic dysfunction. We discuss recent data obtained with genetically modified mice and pharmacological approaches suggesting that these inflammatory pathways are potential novel pharmacological targets for the management of obesity-associated insulin resistance.

  11. The role of grain size in He bubble formation: Implications for swelling resistance

    Energy Technology Data Exchange (ETDEWEB)

    El-Atwani, O., E-mail: oelatwan25@gmail.com [Drexel University, Department of Materials Science & Engineering, Philadelphia, PA (United States); Nathaniel, J.E.; Leff, A.C. [Drexel University, Department of Materials Science & Engineering, Philadelphia, PA (United States); Muntifering, B.R. [Department of Radiation Solid Interactions, Sandia National Laboratories, NM (United States); Baldwin, J.K. [Center for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, NM (United States); Hattar, K. [Department of Radiation Solid Interactions, Sandia National Laboratories, NM (United States); Taheri, M.L. [Drexel University, Department of Materials Science & Engineering, Philadelphia, PA (United States)

    2017-02-15

    Nanocrystalline metals are postulated as radiation resistant materials due to their high defect and particle (e.g. Helium) sink density. Here, the performance of nanocrystalline iron films is investigated in-situ in a transmission electron microscope (TEM) using He irradiation at 700 K. Automated crystal orientation mapping is used in concert with in-situ TEM to explore the role of grain orientation and grain boundary character on bubble density trends. Bubble density as a function of three key grain size regimes is demonstrated. While the overall trend revealed an increase in bubble density up to a saturation value, grains with areas ranging from 3000 to 7500 nm{sup 2} show a scattered distribution. An extrapolated swelling resistance based on bubble size and areal density indicated that grains with sizes less than 2000 nm{sup 2} possess the greatest apparent resistance. Moreover, denuded zones are found to be independent of grain size, grain orientation, and grain boundary misorientation angle.

  12. BIOCIDAL PRODUCTS – IMPLICATIONS OF THEIR USAGE IN THE ANTIBIOTIC RESISTANCE INITIATION

    Directory of Open Access Journals (Sweden)

    Mariana Dumitrache

    2016-12-01

    Full Text Available Biocidal products are necessary in our lives in order to protect us against pathogenic microorganisms. But their use must be subject to a strict regulation because their harmful potential on human and animal health and environment is huge. Biocidal products must be authorized by a competent authority before placing them on the market and all active substances from their composition must be tested and certified to ensure they are in compliance with regulatory requirements in the field. Also biocides, with antimicrobials, may be involved in causing the phenomenon of antibiotic resistance. Their misuse can lead to the emergence of resistant organisms, through mechanisms similar to those that appear in incorrect treatment with antibiotics. We should, therefore, be aware of this aspect particularly important to prevent unwanted effects of cross resistance to antibiotics and biocides. The more so as, lately, there are pulled many alarm signals about the fact that, in a very short time, mankind is in danger of remaining without the main arsenal for fighting harmful microorganisms.

  13. Spatial distribution of single-nucleotide polymorphisms related to fungicide resistance and implications for sampling.

    Science.gov (United States)

    Van der Heyden, H; Dutilleul, P; Brodeur, L; Carisse, O

    2014-06-01

    Spatial distribution of single-nucleotide polymorphisms (SNPs) related to fungicide resistance was studied for Botrytis cinerea populations in vineyards and for B. squamosa populations in onion fields. Heterogeneity in this distribution was characterized by performing geostatistical analyses based on semivariograms and through the fitting of discrete probability distributions. Two SNPs known to be responsible for boscalid resistance (H272R and H272Y), both located on the B subunit of the succinate dehydrogenase gene, and one SNP known to be responsible for dicarboximide resistance (I365S) were chosen for B. cinerea in grape. For B. squamosa in onion, one SNP responsible for dicarboximide resistance (I365S homologous) was chosen. One onion field was sampled in 2009 and another one was sampled in 2010 for B. squamosa, and two vineyards were sampled in 2011 for B. cinerea, for a total of four sampled sites. Cluster sampling was carried on a 10-by-10 grid, each of the 100 nodes being the center of a 10-by-10-m quadrat. In each quadrat, 10 samples were collected and analyzed by restriction fragment length polymorphism polymerase chain reaction (PCR) or allele specific PCR. Mean SNP incidence varied from 16 to 68%, with an overall mean incidence of 43%. In the geostatistical analyses, omnidirectional variograms showed spatial autocorrelation characterized by ranges of 21 to 1 m. Various levels of anisotropy were detected, however, with variograms computed in four directions (at 0°, 45°, 90°, and 135° from the within-row direction used as reference), indicating that spatial autocorrelation was prevalent or characterized by a longer range in one direction. For all eight data sets, the β-binomial distribution was found to fit the data better than the binomial distribution. This indicates local aggregation of fungicide resistance among sampling units, as supported by estimates of the parameter θ of the β-binomial distribution of 0.09 to 0.23 (overall median value = 0

  14. Public health implications of contamination of Franc CFA (XAF) circulating in Buea (Cameroon) with drug resistant pathogens.

    Science.gov (United States)

    Akoachere, Jane-Francis Tatah Kihla; Gaelle, Nana; Dilonga, Henry Meriki; Nkuo-Akenji, Theresa K

    2014-01-08

    Studies in different parts of the world have implicated money as a vehicle for transmission of pathogens. Such information which is necessary to facilitate infection control strategies is lacking in many sub-Saharan countries including Cameroon. This study analyzed the Franc de la Communauté Financiere d'Afrique (Franc CFA), the currency used in Cameroon and other countries in the Central African sub-region, as a potential vehicle for transmission of pathogenic bacteria and fungi, particularly drug-resistant strains, to generate findings which could create awareness on currency contamination and serve as a guide when formulating health policies on currency. Two hundred and thirteen currency samples representing various denominations of notes and coins randomly collected from diverse sources in Buea, Cameroon were analyzed for bacteria and fungi. The sensitivity of bacterial isolates to antibiotics was tested using the disc diffusion method. The relationship between contamination and physical state, source or denomination of currency was assessed using the χ2 test. All statistics were discussed at 0.05 significance level. Two hundred (93.9%) samples were contaminated with notes (96.6%) showing higher contamination than coins (88.2%). Uncirculated (mint) samples showed no contamination. There was a significant difference (PCFA franc circulating in Buea could serve as a vehicle for transmission of drug resistant pathogenic or potential organisms and contamination could be due to currency usage and handling as mint notes were not contaminated. Hygiene practices during or after handling currency is greatly encouraged to prevent infection.

  15. Detailed mutational analysis of Vga(A) interdomain linker: Implication for antibiotic resistance specificity and mechanism

    Czech Academy of Sciences Publication Activity Database

    Lenart, Jakub; Vimberg, Vladimír; Veselá, Ludmila; Janata, Jiří; Balíková Novotná, Gabriela

    2015-01-01

    Roč. 59, č. 2 (2015), s. 1360-1364 ISSN 0066-4804 R&D Projects: GA MŠk(CZ) ED1.1.00/02.0109; GA MŠk(CZ) EE2.3.20.0055; GA MŠk(CZ) EE2.3.30.0003; GA ČR GPP302/12/P632 Institutional support: RVO:61388971 Keywords : antibiotic * resistance * Vga(A) Subject RIV: EE - Microbiology, Virology Impact factor: 4.415, year: 2015

  16. The development of pathogen resistance in Daphnia magna: implications for disease spread in age-structured populations.

    Science.gov (United States)

    Garbutt, Jennie S; O'Donoghue, Anna J P; McTaggart, Seanna J; Wilson, Philip J; Little, Tom J

    2014-11-01

    Immunity in vertebrates is well established to develop with time, but the ontogeny of defence in invertebrates is markedly less studied. Yet, age-specific capacity for defence against pathogens, coupled with age structure in populations, has widespread implications for disease spread. Thus, we sought to determine the susceptibility of hosts of different ages in an experimental invertebrate host-pathogen system. In a series of experiments, we show that the ability of Daphnia magna to resist its natural bacterial pathogen Pasteuria ramosa changes with host age. Clonal differences make it difficult to draw general conclusions, but the majority of observations indicate that resistance increases early in the life of D. magna, consistent with the idea that the defence system develops with time. Immediately following this, at about the time when a daphnid would be most heavily investing in reproduction, resistance tends to decline. Because many ecological factors influence the age structure of Daphnia populations, our results highlight a broad mechanism by which ecological context can affect disease epidemiology. We also show that a previously observed protective effect of restricted maternal food persists throughout the entire juvenile period, and that the protective effect of prior treatment with a small dose of the pathogen ('priming') persists for 7 days, observations that reinforce the idea that immunity in D. magna can change over time. Together, our experiments lead us to conclude that invertebrate defence capabilities have an ontogeny that merits consideration with respect to both their immune systems and the epidemic spread of infection. © 2014. Published by The Company of Biologists Ltd.

  17. FORCE-VELOCITY, IMPULSE-MOMENTUM RELATIONSHIPS: IMPLICATIONS FOR EFFICACY OF PURPOSEFULLY SLOW RESISTANCE TRAINING

    Directory of Open Access Journals (Sweden)

    Brian K. Schilling

    2008-06-01

    Full Text Available The purpose of this brief review is to explain the mechanical relationship between impulse and momentum when resistance exercise is performed in a purposefully slow manner (PS. PS is recognized by ~10s concentric and ~4-10s eccentric actions. While several papers have reviewed the effects of PS, none has yet explained such resistance training in the context of the impulse-momentum relationship. A case study of normal versus PS back squats was also performed. An 85kg man performed both normal speed (3 sec eccentric action and maximal acceleration concentric action and PS back squats over a several loads. Normal speed back squats produced both greater peak and mean propulsive forces than PS action when measured across all loads. However, TUT was greatly increased in the PS condition, with values fourfold greater than maximal acceleration repetitions. The data and explanation herein point to superior forces produced by the neuromuscular system via traditional speed training indicating a superior modality for inducing neuromuscular adaptation

  18. Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy

    Directory of Open Access Journals (Sweden)

    Rogerio M. Castilho

    2017-07-01

    Full Text Available Head and neck squamous carcinoma (HNSCC is the sixth most prevalent cancer and one of the most aggressive malignancies worldwide. Despite continuous efforts to identify molecular markers for early detection, and to develop efficient treatments, the overall survival and prognosis of HNSCC patients remain poor. Accumulated scientific evidences suggest that epigenetic alterations, including DNA methylation, histone covalent modifications, chromatin remodeling and non-coding RNAs, are frequently involved in oral carcinogenesis, tumor progression, and resistance to therapy. Epigenetic alterations occur in an unsystematic manner or as part of the aberrant transcriptional machinery, which promotes selective advantage to the tumor cells. Epigenetic modifications also contribute to cellular plasticity during tumor progression and to the formation of cancer stem cells (CSCs, a small subset of tumor cells with self-renewal ability. CSCs are involved in the development of intrinsic or acquired therapy resistance, and tumor recurrences or relapse. Therefore, the understanding and characterization of epigenetic modifications associated with head and neck carcinogenesis, and the prospective identification of epigenetic markers associated with CSCs, hold the promise for novel therapeutic strategies to fight tumors. In this review, we focus on the current knowledge on epigenetic modifications observed in HNSCC and emerging Epi-drugs capable of sensitizing HNSCC to therapy.

  19. Bioinformatics and structural characterization of a hypothetical protein from Streptococcus mutans: implication of antibiotic resistance.

    Directory of Open Access Journals (Sweden)

    Jie Nan

    2009-10-01

    Full Text Available As an oral bacterial pathogen, Streptococcus mutans has been known as the aetiologic agent of human dental caries. Among a total of 1960 identified proteins within the genome of this organism, there are about 500 without any known functions. One of these proteins, SMU.440, has very few homologs in the current protein databases and it does not fall into any protein functional families. Phylogenetic studies showed that SMU.440 is related to a particular ecological niche and conserved specifically in some oral pathogens, due to lateral gene transfer. The co-occurrence of a MarR protein within the same operon among these oral pathogens suggests that SMU.440 may be associated with antibiotic resistance. The structure determination of SMU.440 revealed that it shares the same fold and a similar pocket as polyketide cyclases, which indicated that it is very likely to bind some polyketide-like molecules. From the interlinking structural and bioinformatics studies, we have concluded that SMU.440 could be involved in polyketide-like antibiotic resistance, providing a better understanding of this hypothetical protein. Besides, the combination of multiple methods in this study can be used as a general approach for functional studies of a protein with unknown function.

  20. On hydraulics of capillary tubes

    Directory of Open Access Journals (Sweden)

    N.G. Aloyan

    2016-03-01

    Full Text Available The article considers the laws of motion of water in the capillary tubes, taken as a model for flowing well, on the analogical net count device. For capillary tube the lower limit value of flow rate is empirically determined above which the total hydraulic resistance of the capillary is practically constant. The specificity of the phenomenon is that the regime of motion, by a Reynolds number, for a given flow rate still remains laminar. This circumstance can perplex the specialists, so the author invites them to the scientific debate on the subject of study. Obviously, to identify the resulting puzzle it is necessary to conduct a series of experiments using capillaries of different lengths and diameters and with different values of overpressure. The article states that in tubes with very small diameter the preliminary magnitude of capillary rise of water in the presence of flow plays no role and can be neglected.

  1. Cavitation in Hydraulic Machinery

    Energy Technology Data Exchange (ETDEWEB)

    Kjeldsen, M.

    1996-11-01

    The main purpose of this doctoral thesis on cavitation in hydraulic machinery is to change focus towards the coupling of non-stationary flow phenomena and cavitation. It is argued that, in addition to turbulence, superimposed sound pressure fluctuations can have a major impact on cavitation and lead to particularly severe erosion. For the design of hydraulic devices this finding may indicate how to further limit the cavitation problems. Chapter 1 reviews cavitation in general in the context of hydraulic machinery, emphasizing the initial cavitation event and the role of the water quality. Chapter 2 discusses the existence of pressure fluctuations for situations common in such machinery. Chapter 3 on cavitation dynamics presents an algorithm for calculating the nucleation of a cavity cluster. Chapter 4 describes the equipment used in this work. 53 refs., 55 figs.,10 tabs.

  2. Spatially resolved ultrasonic attenuation in resistance spot welds: implications for nondestructive testing.

    Science.gov (United States)

    Mozurkewich, George; Ghaffari, Bita; Potter, Timothy J

    2008-09-01

    Spatial variation of ultrasonic attenuation and velocity has been measured in plane parallel specimens extracted from resistance spot welds. In a strong weld, attenuation is larger in the nugget than in the parent material, and the region of increased attenuation is surrounded by a ring of decreased attenuation. In the center of a stick weld, attenuation is even larger than in a strong weld, and the low-attenuation ring is absent. These spatial variations are interpreted in terms of differences in grain size and martensite formation. Measured frequency dependences indicate the presence of an additional attenuation mechanism besides grain scattering. The observed attenuations do not vary as commonly presumed with weld quality, suggesting that the common practice of using ultrasonic attenuation to indicate weld quality is not a reliable methodology.

  3. Clot friction variation with fibrin content; implications for resistance to thrombectomy.

    Science.gov (United States)

    Gunning, Gillian M; McArdle, Kevin; Mirza, Mahmood; Duffy, Sharon; Gilvarry, Michael; Brouwer, Patrick A

    2018-01-01

    Despite significant advancements in the procedural efficacy of mechanical thrombectomy in patients with ischemic stroke in recent years, there still remains a portion of the population that does not achieve good recanalization. The reasons for this may be varied. We hypothesized that static friction between the clot and the vessel, or catheter wall might contribute to the difficulty in removing the clot. To determine if there is a relationship between clot composition and the resistance to sliding (friction) which might contribute to resistance to clot removal. As clot composition can vary significantly, we investigated five different types of clot in order to measure their respective frictional properties. To do this, a custom-made testing apparatus was created, consisting of various replaceable low-friction surfaces on which the clots could be placed. The surface was then gradually tilted until the clots began to slide; the angle at which this occurred is related to the coefficient of friction of the clots. The experiment was repeated on a bovine aortic surface in order to confirm the results. We found that fibrin-rich clots (friction than clots with a red blood cell content >20%. This result was confirmed by repeating the experiment on a bovine aortic surface as a representation of the interaction between clots and the arterial wall. The friction properties of clots were found to be related to the content ratio of fibrin to red blood cells. Future imaging techniques that could show fibrin and red blood cell content might help us to predict the 'stickiness' of a clot. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  4. Hydraulics and pneumatics

    CERN Document Server

    Parr, Andrew

    2006-01-01

    Nearly all industrial processes require objects to be moved, manipulated or subjected to some sort of force. This is frequently accomplished by means of electrical equipment (such as motors or solenoids), or via devices driven by air (pneumatics) or liquids (hydraulics).This book has been written by a process control engineer as a guide to the operation of hydraulic and pneumatic systems for all engineers and technicians who wish to have an insight into the components and operation of such a system.This second edition has been fully updated to include all recent developments su

  5. HYDRAULIC SERVO CONTROL MECHANISM

    Science.gov (United States)

    Hussey, R.B.; Gottsche, M.J. Jr.

    1963-09-17

    A hydraulic servo control mechanism of compact construction and low fluid requirements is described. The mechanism consists of a main hydraulic piston, comprising the drive output, which is connected mechanically for feedback purposes to a servo control piston. A control sleeve having control slots for the system encloses the servo piston, which acts to cover or uncover the slots as a means of controlling the operation of the system. This operation permits only a small amount of fluid to regulate the operation of the mechanism, which, as a result, is compact and relatively light. This mechanism is particuiarly adaptable to the drive and control of control rods in nuclear reactors. (auth)

  6. Hydraulic Arm Modeling via Matlab SimHydraulics

    Czech Academy of Sciences Publication Activity Database

    Věchet, Stanislav; Krejsa, Jiří

    2009-01-01

    Roč. 16, č. 4 (2009), s. 287-296 ISSN 1802-1484 Institutional research plan: CEZ:AV0Z20760514 Keywords : simulatin modeling * hydraulics * SimHydraulics Subject RIV: JD - Computer Applications, Robotics

  7. Self-potential observations during hydraulic fracturing

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Jeffrey R.; Glaser, Steven D.

    2007-09-13

    The self-potential (SP) response during hydraulic fracturing of intact Sierra granite was investigated in the laboratory. Excellent correlation of pressure drop and SP suggests that the SP response is created primarily by electrokinetic coupling. For low pressures, the variation of SP with pressure drop is linear, indicating a constant coupling coefficient (Cc) of -200 mV/MPa. However for pressure drops >2 MPa, the magnitude of the Cc increases by 80% in an exponential trend. This increasing Cc is related to increasing permeability at high pore pressures caused by dilatancy of micro-cracks, and is explained by a decrease in the hydraulic tortuosity. Resistivity measurements reveal a decrease of 2% prior to hydraulic fracturing and a decrease of {approx}35% after fracturing. An asymmetric spatial SP response created by injectate diffusion into dilatant zones is observed prior to hydraulic fracturing, and in most cases this SP variation revealed the impending crack geometry seconds before failure. At rupture, injectate rushes into the new fracture area where the zeta potential is different than in the rock porosity, and an anomalous SP spike is observed. After fracturing, the spatial SP distribution reveals the direction of fracture propagation. Finally, during tensile cracking in a point load device with no water flow, a SP spike is observed that is caused by contact electrification. However, the time constant of this event is much less than that for transients observed during hydraulic fracturing, suggesting that SP created solely from material fracture does not contribute to the SP response during hydraulic fracturing.

  8. Mine drivage in hydraulic mines

    Energy Technology Data Exchange (ETDEWEB)

    Ehkber, B Ya

    1983-09-01

    From 20 to 25% of labor cost in hydraulic coal mines falls on mine drivage. Range of mine drivage is high due to the large number of shortwalls mined by hydraulic monitors. Reducing mining cost in hydraulic mines depends on lowering drivage cost by use of new drivage systems or by increasing efficiency of drivage systems used at present. The following drivage methods used in hydraulic mines are compared: heading machines with hydraulic haulage of cut rocks and coal, hydraulic monitors with hydraulic haulage, drilling and blasting with hydraulic haulage of blasted rocks. Mining and geologic conditions which influence selection of the optimum mine drivage system are analyzed. Standardized cross sections of mine roadways driven by the 3 methods are shown in schemes. Support systems used in mine roadways are compared: timber supports, roof bolts, roof bolts with steel elements, and roadways driven in rocks without a support system. Heading machines (K-56MG, GPKG, 4PU, PK-3M) and hydraulic monitors (GMDTs-3M, 12GD-2) used for mine drivage are described. Data on mine drivage in hydraulic coal mines in the Kuzbass are discussed. From 40 to 46% of roadways are driven by heading machines with hydraulic haulage and from 12 to 15% by hydraulic monitors with hydraulic haulage.

  9. Effects of age-related increases in sapwood area, leaf area, and xylem conductivity on height-related hydraulic costs in two contrasting coniferous species

    Science.gov (United States)

    Jean-Christophe Domec; Barbara Lachenbruch; Michele L. Pruyn; Rachel Spicer

    2012-01-01

    Introduction: Knowledge of vertical variation in hydraulic parameters would improve our understanding of individual trunk functioning and likely have important implications for modeling water movement to the leaves. Specifically, understanding how foliage area (Al), sapwood area (As), and hydraulic specific...

  10. Micro-minicircle Gene Therapy: Implications of Size on Fermentation, Complexation, Shearing Resistance, and Expression

    Directory of Open Access Journals (Sweden)

    Sofia Stenler

    2014-01-01

    Full Text Available The minicircle (MC, composed of eukaryotic sequences only, is an interesting approach to increase the safety and efficiency of plasmid-based vectors for gene therapy. In this paper, we investigate micro-MC (miMC vectors encoding small regulatory RNA. We use a construct encoding a splice-correcting U7 small nuclear RNA, which results in a vector of 650 base pairs (bp, as compared to a conventional 3600 bp plasmid carrying the same expression cassette. Furthermore, we construct miMCs of varying sizes carrying different number of these cassettes. This allows us to evaluate how size influences production, super-coiling, stability and efficiency of the vector. We characterize coiling morphology by atomic force microscopy and measure the resistance to shearing forces caused by an injector device, the Biojector. We compare the behavior of miMCs and plasmids in vitro using lipofection and electroporation, as well as in vivo in mice. We here show that when the size of the miMC is reduced, the formation of dimers and trimers increases. There seems to be a lower size limit for efficient expression. We demonstrate that miMCs are more robust than plasmids when exposed to shearing forces, and that they show extended expression in vivo.

  11. Smoking impact on grip strength and fatigue resistance: implications for exercise and hand therapy practice.

    Science.gov (United States)

    Al-Obaidi, Saud; Al-Sayegh, Nowall; Nadar, Mohammed

    2014-07-01

    Grip strength assessment reflects on overall health of the musculoskeletal system and is a predictor of functional prognosis and mortality. The purpose of this study was: examine whether grip-strength and fatigue resistance are impaired in smokers, determine if smoking-related impairments (fatigue-index) can be predicted by demographic data, duration of smoking, packets smoked-per-day, and physical activity. Maximum isometric grip strength (MIGS) of male smokers (n = 111) and nonsmokers (n = 66) was measured before/after induced fatigue using Jamar dynamometer at 5-handle positions. Fatigue index was calculated based on percentage change in MIGS initially and after induced fatigue. Number of repetitions to squeeze the soft rubber ball to induce fatigue was significantly lower in smokers compared with nonsmokers (t = 10.6, P smoking status on MIGS scores was significantly different between smokers and nonsmokers after induced fatigue (β = -3.98, standard error = 0.59, P Smoking status was the strongest significant independent predictor of the fatigue-index. Smokers demonstrated reduced grip strength and fast fatigability in comparison with nonsmokers.

  12. A review of the clinical implications of anti-infective biomaterials and infection-resistant surfaces.

    Science.gov (United States)

    Campoccia, Davide; Montanaro, Lucio; Arciola, Carla Renata

    2013-11-01

    Infection is currently regarded as the most severe and devastating complication associated to the use of biomaterials. The important social, clinical and economic impacts of implant-related infections are promoting the efforts to obviate these severe diseases. In this context, the development of anti-infective biomaterials and of infection-resistant surfaces is being regarded as the main strategy to prevent the establishment of implant colonisation and biofilm formation by bacteria. In this review, the attention is focused on the biomaterial-associated infections, from which the need for anti-infective biomaterials originates. Biomaterial-associated infections differ markedly for epidemiology, aetiology and severity, depending mainly on the anatomic site, on the time of biomaterial application, and on the depth of the tissues harbouring the prosthesis. Here, the diversity and complexity of the different scenarios where medical devices are currently utilised are explored, providing an overview of the emblematic applicative fields and of the requirements for anti-infective biomaterials. © 2013 Elsevier Ltd. All rights reserved.

  13. Past, Present, and Future of Antibacterial Economics: Increasing Bacterial Resistance, Limited Antibiotic Pipeline, and Societal Implications.

    Science.gov (United States)

    Luepke, Katherine H; Suda, Katie J; Boucher, Helen; Russo, Rene L; Bonney, Michael W; Hunt, Timothy D; Mohr, John F

    2017-01-01

    Growing antimicrobial resistance and a dwindling antibiotic pipeline have resulted in an emerging postantibiotic era, as patients are now dying from bacterial infections that were once treatable. The fast-paced "Golden Age" of antibiotic development that started in the 1940s has lost momentum; from the 1980s to the early 2000s, there was a 90% decline in the approval of new antibiotics as well as the discovery of few new novel classes. Many companies have shifted away from development due to scientific, regulatory, and economic hurdles that proved antibiotic development to be less attractive compared with more lucrative therapeutic areas. National and global efforts are focusing attention toward potential solutions for reinvigorating the antibiotic pipeline and include "push" incentives such as public-private partnerships and "pull" incentives such as reimbursement reform and market exclusivity. Hybrid models of incentives, global coordination among stakeholders, and the appropriate balance of antibiotic pricing, volume of drug used, and proper antimicrobial stewardship are key to maximizing efforts toward drug development to ensure access to patients in need of these therapies. © 2016 Pharmacotherapy Publications, Inc.

  14. Hydraulic shock absorbers

    International Nuclear Information System (INIS)

    Thatcher, G.; Davidson, D. F.

    1984-01-01

    A hydraulic shock absorber of the dash pot kind for use with electrically conducting liquid such as sodium, has magnet means for electro magnetically braking a stream of liquid discharged from the cylinder. The shock absorber finds use in a liquid metal cooled nuclear reactor for arresting control rods

  15. Preparation of hydraulic cement

    Energy Technology Data Exchange (ETDEWEB)

    1921-08-28

    A process for the preparation of hydraulic cement by the use of oil-shale residues is characterized in that the oil-shale refuse is mixed with granular basic blast-furnace slag and a small amount of portland cement and ground together.

  16. Small hydraulic turbine drives

    Science.gov (United States)

    Rostafinski, W. A.

    1970-01-01

    Turbine, driven by the fluid being pumped, requires no external controls, is completely integrated into the flow system, and has bearings which utilize the main fluid for lubrication and cooling. Torque capabilities compare favorably with those developed by positive displacement hydraulic motors.

  17. Modelling of Hydraulic Robot

    DEFF Research Database (Denmark)

    Madsen, Henrik; Zhou, Jianjun; Hansen, Lars Henrik

    1997-01-01

    This paper describes a case study of identifying the physical model (or the grey box model) of a hydraulic test robot. The obtained model is intended to provide a basis for model-based control of the robot. The physical model is formulated in continuous time and is derived by application...

  18. Manual Hydraulic Structures

    NARCIS (Netherlands)

    Molenaar, W.F.; Voorendt, M.Z.

    This manual is the result of group work and origins in Dutch lecture notes that have been used since long time. Amongst the employees of the Hydraulic Engineering Department that contributed to this work are dr.ir. S. van Baars, ir.K.G.Bezuijen, ir.G.P.Bourguignon, prof.ir.A.Glerum,

  19. Water Treatment Technology - Hydraulics.

    Science.gov (United States)

    Ross-Harrington, Melinda; Kincaid, G. David

    One of twelve water treatment technology units, this student manual on hydraulics provides instructional materials for three competencies. (The twelve units are designed for a continuing education training course for public water supply operators.) The competencies focus on the following areas: head loss in pipes in series, function loss in…

  20. Recycling and Resistance of Petrogenic Particulate Organic Carbon: Implications from A Chemical Oxidation Method

    Science.gov (United States)

    Zhang, T.; Li, G.; Ji, J.

    2013-12-01

    Petrogenic particulate organic carbon (OCpetro) represents a small fraction of photosynthetic carbon which escapes pedogenic-petrogenic degradation and gets trapped in the lithosphere. Exhumation and recycling of OCpetro are of significant importance in the global carbon cycle because OCpetro oxidation represents a substantial carbon source to the atmosphere while the re-burial of OCpetro in sediment deposits has no net effect. Though studies have investigated various behaviors of OCpetro in the surface environments (e.g., riverine mobilization, marine deposition, and microbial remineralization), less attention has been paid to the reaction kinetics and structural transformations during OCpetro oxidation. Here we assess the OCpetro-oxidation process based on a chemical oxidation method adopted from soil studies. The employed chemical oxidation method is considered an effective simulation of natural oxidation in highly oxidative environments, and has been widely used in soil studies to isolate the inert soil carbon pool. We applied this chemical method to the OCpetro-enriched black shale samples from the middle-lower Yangtze (Changjiang) basin, China, and performed comprehensive instrumental analyses (element analysis, Fourier transform infrared (FTIR) spectrum, and Raman spectrum). We also conducted step-oxidizing experiments following fixed time series and monitored the reaction process in rigorously controlled lab conditions. In this work, we present our experiment results and discuss the implications for the recycling and properties of OCpetro. Particulate organic carbon concentration of black shale samples before and after oxidation helps to quantify the oxidability of OCpetro and constrain the preservation efficiency of OCpetro during fluvial erosion over large river basin scales. FTIR and Raman analyses reveal clear structural variations on atomic and molecular levels. Results from the step-oxidizing experiments provide detailed information about the reaction

  1. An analysis of genetic diversity and inbreeding in Wuchereria bancrofti: implications for the spread and detection of drug resistance.

    Directory of Open Access Journals (Sweden)

    Thomas S Churcher

    2008-04-01

    Full Text Available Estimates of genetic diversity in helminth infections of humans often have to rely on genotyping (immature parasite transmission stages instead of adult worms. Here we analyse the results of one such study investigating a single polymorphic locus (a change at position 200 of the beta-tubulin gene in microfilariae of the lymphatic filarial parasite Wuchereria bancrofti. The presence of this genetic change has been implicated in benzimidazole resistance in parasitic nematodes of farmed ruminants. Microfilariae were obtained from patients of three West African villages, two of which were sampled prior to the introduction of mass drug administration. An individual-based stochastic model was developed showing that a wide range of allele frequencies in the adult worm populations could have generated the observed microfilarial genetic diversity. This suggests that appropriate theoretical null models are required in order to interpret studies that genotype transmission stages. Wright's hierarchical F-statistic was used to investigate the population structure in W. bancrofti microfilariae and showed significant deficiency of heterozygotes compared to the Hardy-Weinberg equilibrium; this may be partially caused by a high degree of parasite genetic differentiation between hosts. Studies seeking to quantify accurately the genetic diversity of helminth populations by analysing transmission stages should increase their sample size to account for the variability in allele frequency between different parasite life-stages. Helminth genetic differentiation between hosts and non-random mating will also increase the number of hosts (and the number of samples per host that need to be genotyped, and could enhance the rate of spread of anthelmintic resistance.

  2. Comparison of Linezolid and Vancomycin for Methicillin-Resistant Staphylococcus aureus Pneumonia: Institutional Implications.

    Science.gov (United States)

    Tong, ManShan C; Wisniewski, Christopher S; Wolf, Bethany; Bosso, John A

    2016-07-01

    Recent studies suggesting clinical superiority of linezolid over vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia led to a change in our institution's clinical pathway/order form for hospital-acquired pneumonia, positioning linezolid as the preferred agent. Our objective was to assess the impact of this change within our institution. Retrospective electronic medical records review. The analysis for this observational study included eligible patients admitted to our medical center between May 1, 2011, and August 31, 2014, with ICD-9 codes for MRSA and pneumonia. Included patients were at least 18 years of age and had vancomycin or linezolid initiated at least 2 days after admission and continued for at least 2 consecutive days. The primary end points were extent of antibiotic use before and after order form change and length of stay (LOS) and hospital charges in the two treatment groups. A secondary aim was to detect any gross discrepancies in patient outcomes such as treatment duration, mechanical ventilation duration, all-cause mortality rate, nephrotoxicity, and 30-day readmission between the two treatment groups. Outcomes in 227 patients were assessed. Linezolid use increased 16.2% subsequent to the change in the order form. Although not statistically significant, the median hospital admission charge was $6200 lower in patients treated with linezolid compared with those treated with vancomycin ($25,900 vs $32,100). Hospital LOS was significantly associated with Charlson Comorbidity Index score (plinezolid treatment, and these patients were more likely to be discharged (shorter LOS). Although linezolid use increased markedly with this pathway/order form change, no negative institutional consequences or unfavorable patient outcomes were detected, justifying the change in policy from these perspectives. © 2016 Pharmacotherapy Publications, Inc.

  3. Development of partial ontogenic resistance to powdery mildew in hop cones and its management implications.

    Directory of Open Access Journals (Sweden)

    Megan C Twomey

    Full Text Available Knowledge of processes leading to crop damage is central to devising rational approaches to disease management. Multiple experiments established that infection of hop cones by Podosphaera macularis was most severe if inoculation occurred within 15 to 21 days after bloom. This period of infection was associated with the most pronounced reductions in alpha acids, cone color, and accelerated maturation of cones. Susceptibility of cones to powdery mildew decreased progressively after the transition from bloom to cone development, although complete immunity to the disease failed to develop. Maturation of cone tissues was associated with multiple significant affects on the pathogen manifested as reduced germination of conidia, diminished frequency of penetration of bracts, lengthening of the latent period, and decreased sporulation. Cones challenged with P. macularis in juvenile developmental stages also led to greater frequency of colonization by a complex of saprophytic, secondary fungi. Since no developmental stage of cones was immune to powdery mildew, the incidence of powdery mildew continued to increase over time and exceeded 86% by late summer. In field experiments with a moderately susceptible cultivar, the incidence of cones with powdery mildew was statistically similar when fungicide applications were made season-long or targeted only to the juvenile stages of cone development. These studies establish that partial ontogenic resistance develops in hop cones and may influence multiple phases of the infection process and pathogen reproduction. The results further reinforce the concept that the efficacy of a fungicide program may depend largely on timing of a small number of sprays during a relatively brief period of cone development. However in practice, targeting fungicide and other management tactics to periods of enhanced juvenile susceptibility may be complicated by a high degree of asynchrony in cone development and other factors that are

  4. Cradle modification for hydraulic ram

    International Nuclear Information System (INIS)

    Koons, B.M.

    1995-01-01

    The analysis of the cradle hydraulic system considers stress, weld strength, and hydraulic forces required to lift and support the cradle/pump assembly. The stress and weld strength of the cradle modifications is evaluated to ensure that they meet the requirements of the American Institute for Steel Construction (AISC 1989). The hydraulic forces are evaluated to ensure that the hydraulic system is capable of rotating the cradle and pump assembly to the vertical position (between 70 degrees and 90 degrees)

  5. Assimilation of temperature and hydraulic gradients for quantifying the spatial variability of streambed hydraulics

    Science.gov (United States)

    Huang, Xiang; Andrews, Charles B.; Liu, Jie; Yao, Yingying; Liu, Chuankun; Tyler, Scott W.; Selker, John S.; Zheng, Chunmiao

    2016-08-01

    the result of heterogeneous streambed hydraulic characteristics in these areas. Our results have significant implications for hyporheic micro-habitats, fish spawning and other wildlife incubation, regional flow and hyporheic solute transport models in the Heihe River Basin, as well as in other similar hydrologic settings.

  6. Hydraulic turbines and auxiliary equipment

    Energy Technology Data Exchange (ETDEWEB)

    Luo Gaorong [Organization of the United Nations, Beijing (China). International Centre of Small Hydroelectric Power Plants

    1995-07-01

    This document presents a general overview on hydraulic turbines and auxiliary equipment, emphasizing the turbine classification, in accordance with the different types of turbines, standard turbine series in China, turbine selection based on the basic data required for the preliminary design, general hill model curves, chart of turbine series and the arrangement of application for hydraulic turbines, hydraulic turbine testing, and speed regulating device.

  7. Hydraulic Hybrid Vehicle Publications | Transportation Research | NREL

    Science.gov (United States)

    Hydraulic Hybrid Vehicle Publications Hydraulic Hybrid Vehicle Publications The following technical papers and fact sheets provide information about NREL's hydraulic hybrid fleet vehicle evaluations . Refuse Trucks Project Startup: Evaluating the Performance of Hydraulic Hybrid Refuse Vehicles. Bob

  8. Daptomycin versus linezolid for the treatment of vancomycin-resistant enterococcal bacteraemia: implications of daptomycin dose.

    Science.gov (United States)

    Chuang, Y-C; Lin, H-Y; Chen, P-Y; Lin, C-Y; Wang, J-T; Chang, S-C

    2016-10-01

    Treatment options for vancomycin-resistant enterococci (VRE) bloodstream infection are limited. Studies comparing daptomycin or linezolid in treating VRE bloodstream infection have conflicting results and suggest daptomycin underdosing. The responses to different daptomycin doses have not been studied. We conducted a multicentre prospective cohort study to compare linezolid and daptomycin (≥6 mg/kg) for the treatment of VRE bloodstream infection. The primary outcome was 14-day mortality. We used multivariate logistic regression analysis for outcome analysis and a generalized additive model for dose-dependent response estimation. Two hundred twelve patients were included (daptomycin, n = 141; linezolid, n = 71). All-cause 14-day mortality was higher in the daptomycin group (36.9% vs. 21.1%; p 0.03). After adjusting for confounders in logistic regression, mortality was lower in the linezolid group (adjusted odds ratio (aOR), 0.45; 95% confidence interval (CI), 0.21-0.96; p 0.04). The generalized additive model showed that higher-dose daptomycin (≥9 mg/kg) was associated with better survival than lower-dose daptomycin (6-9 mg/kg). Logistic regression showed that linezolid (aOR, 0.36; 95% CI, 0.17-0.79; p 0.01) and higher-dose daptomycin (aOR, 0.26; 95% CI, 0.09-0.74; p 0.01) independently predicted lower mortality compared to lower-dose daptomycin. Linezolid was not superior to higher-dose daptomycin in terms of mortality (aOR, 1.40; 95% CI, 0.45-4.37; p 0.57). Higher-dose daptomycin had lower mortality than lower-dose daptomycin. Despite higher mortality for lower-dose daptomycin than linezolid, linezolid conferred no survival benefit compared to higher-dose daptomycin. Our findings suggest that the recommended daptomycin dose is suboptimal for treating VRE bacteraemia. Copyright © 2016. Published by Elsevier Ltd.

  9. Interaction of osteopontin with IL-18 in obese individuals: implications for insulin resistance.

    Directory of Open Access Journals (Sweden)

    Rasheed Ahmad

    other in overweight/obese individuals which may trigger the development of obesity-associated insulin resistance. Moreover, these results provide the direct evidence that IL-18 regulates OPN production in PBMCs.

  10. Trade-offs between xylem hydraulic properties, wood anatomy and yield in Populus.

    Science.gov (United States)

    Hajek, Peter; Leuschner, Christoph; Hertel, Dietrich; Delzon, Sylvain; Schuldt, Bernhard

    2014-07-01

    Trees face the dilemma that achieving high plant productivity is accompanied by a risk of drought-induced hydraulic failure due to a trade-off in the trees' vascular system between hydraulic efficiency and safety. By investigating the xylem anatomy of branches and coarse roots, and measuring branch axial hydraulic conductivity and vulnerability to cavitation in 4-year-old field-grown aspen plants of five demes (Populus tremula L. and Populus tremuloides Michx.) differing in growth rate, we tested the hypotheses that (i) demes differ in wood anatomical and hydraulic properties, (ii) hydraulic efficiency and safety are related to xylem anatomical traits, and (iii) aboveground productivity and hydraulic efficiency are negatively correlated to cavitation resistance. Significant deme differences existed in seven of the nine investigated branch-related anatomical and hydraulic traits but only in one of the four coarse-root-related anatomical traits; this likely is a consequence of high intra-plant variation in root morphology and the occurrence of a few 'high-conductivity roots'. Growth rate was positively related to branch hydraulic efficiency (xylem-specific conductivity) but not to cavitation resistance; this indicates that no marked trade-off exists between cavitation resistance and growth. Both branch hydraulic safety and hydraulic efficiency significantly depended on vessel size and were related to the genetic distance between the demes, while the xylem pressure causing 88% loss of hydraulic conductivity (P88 value) was more closely related to hydraulic efficiency than the commonly used P50 value. Deme-specific variation in the pit membrane structure may explain why vessel size was not directly linked to growth rate. We conclude that branch hydraulic efficiency is an important growth-influencing trait in aspen, while the assumed trade-off between productivity and hydraulic safety is weak. © The Author 2014. Published by Oxford University Press. All rights reserved

  11. Hydraulic manipulator research at ORNL

    International Nuclear Information System (INIS)

    Kress, R.L.; Jansen, J.F.; Love, L.J.

    1997-01-01

    Recently, task requirements have dictated that manipulator payload capacity increase to accommodate greater payloads, greater manipulator length, and larger environmental interaction forces. General tasks such as waste storage tank cleanup and facility dismantlement and decommissioning require manipulator life capacities in the range of hundreds of pounds rather than tens of pounds. To meet the increased payload capacities demanded by present-day tasks, manipulator designers have turned once again to hydraulics as a means of actuation. In order to successfully design, build, and deploy a new hydraulic manipulator (or subsystem), sophisticated modeling, analysis, and control experiments are usually needed. Oak Ridge National Laboratory (ORNL) has a history of projects that incorporate hydraulics technology, including mobile robots, teleoperated manipulators, and full-scale construction equipment. In addition, to support the development and deployment of new hydraulic manipulators, ORNL has outfitted a significant experimental laboratory and has developed the software capability for research into hydraulic manipulators, hydraulic actuators, hydraulic systems, modeling of hydraulic systems, and hydraulic controls. The purpose of this article is to describe the past hydraulic manipulator developments and current hydraulic manipulator research capabilities at ORNL. Included are example experimental results from ORNL's flexible/prismatic test stand

  12. Hydraulic manipulator research at ORNL

    Energy Technology Data Exchange (ETDEWEB)

    Kress, R.L.; Jansen, J.F. [Oak Ridge National Lab., TN (United States); Love, L.J. [Oak Ridge Inst. for Science and Education, TN (United States)

    1997-03-01

    Recently, task requirements have dictated that manipulator payload capacity increase to accommodate greater payloads, greater manipulator length, and larger environmental interaction forces. General tasks such as waste storage tank cleanup and facility dismantlement and decommissioning require manipulator life capacities in the range of hundreds of pounds rather than tens of pounds. To meet the increased payload capacities demanded by present-day tasks, manipulator designers have turned once again to hydraulics as a means of actuation. In order to successfully design, build, and deploy a new hydraulic manipulator (or subsystem), sophisticated modeling, analysis, and control experiments are usually needed. Oak Ridge National Laboratory (ORNL) has a history of projects that incorporate hydraulics technology, including mobile robots, teleoperated manipulators, and full-scale construction equipment. In addition, to support the development and deployment of new hydraulic manipulators, ORNL has outfitted a significant experimental laboratory and has developed the software capability for research into hydraulic manipulators, hydraulic actuators, hydraulic systems, modeling of hydraulic systems, and hydraulic controls. The purpose of this article is to describe the past hydraulic manipulator developments and current hydraulic manipulator research capabilities at ORNL. Included are example experimental results from ORNL`s flexible/prismatic test stand.

  13. Hydraulic root water uptake models: old concerns and new insights

    Science.gov (United States)

    Couvreur, V.; Carminati, A.; Rothfuss, Y.; Meunier, F.; Vanderborght, J.; Javaux, M.

    2014-12-01

    Root water uptake (RWU) affects underground water dynamics, with consequences on plant water availability and groundwater recharge. Even though hydrological and climate models are sensitive to RWU parameters, no consensus exists on the modelling of this process. Back in the 1940ies, Van Den Honert's catenary approach was the first to investigate the use of connected hydraulic resistances to describe water flow in whole plants. However concerns such as the necessary computing when architectures get complex made this approach premature. Now that computing power increased dramatically, hydraulic RWU models are gaining popularity, notably because they naturally produce observed processes like compensatory RWU and hydraulic redistribution. Yet major concerns remain. Some are more fundamental: according to hydraulic principles, plant water potential should equilibrate with soil water potential when the plant does not transpire, which is not a general observation when using current definitions of bulk or average soil water potential. Other concerns regard the validation process: water uptake distribution is not directly measurable, which makes it hard to demonstrate whether or not hydraulic models are more accurate than other models. Eventually parameterization concerns exist: root hydraulic properties are not easily measurable, and would even fluctuate on an hourly basis due to processes like aquaporin gating. While offering opportunities to validate hydraulic RWU models, newly developed observation techniques also make us realize the increasing complexity of processes involved in soil-plant hydrodynamics, such as the change of rhizosphere hydraulic properties with soil drying. Surprisingly, once implemented into hydraulic models, these processes do not necessarily translate into more complex emerging behavior at plant scale, and might justify the use of simplified representations of the soil-plant hydraulic system.

  14. Mechanics of Hydraulic Fractures

    Science.gov (United States)

    Detournay, Emmanuel

    2016-01-01

    Hydraulic fractures represent a particular class of tensile fractures that propagate in solid media under pre-existing compressive stresses as a result of internal pressurization by an injected viscous fluid. The main application of engineered hydraulic fractures is the stimulation of oil and gas wells to increase production. Several physical processes affect the propagation of these fractures, including the flow of viscous fluid, creation of solid surfaces, and leak-off of fracturing fluid. The interplay and the competition between these processes lead to multiple length scales and timescales in the system, which reveal the shifting influence of the far-field stress, viscous dissipation, fracture energy, and leak-off as the fracture propagates.

  15. Hydraulically actuated artificial muscles

    Science.gov (United States)

    Meller, M. A.; Tiwari, R.; Wajcs, K. B.; Moses, C.; Reveles, I.; Garcia, E.

    2012-04-01

    Hydraulic Artificial Muscles (HAMs) consisting of a polymer tube constrained by a nylon mesh are presented in this paper. Despite the actuation mechanism being similar to its popular counterpart, which are pneumatically actuated (PAM), HAMs have not been studied in depth. HAMs offer the advantage of compliance, large force to weight ratio, low maintenance, and low cost over traditional hydraulic cylinders. Muscle characterization for isometric and isobaric tests are discussed and compared to PAMs. A model incorporating the effect of mesh angle and friction have also been developed. In addition, differential swelling of the muscle on actuation has also been included in the model. An application of lab fabricated HAMs for a meso-scale robotic system is also presented.

  16. Undular Hydraulic Jump

    Directory of Open Access Journals (Sweden)

    Oscar Castro-Orgaz

    2015-04-01

    Full Text Available The transition from subcritical to supercritical flow when the inflow Froude number Fo is close to unity appears in the form of steady state waves called undular hydraulic jump. The characterization of the undular hydraulic jump is complex due to the existence of a non-hydrostatic pressure distribution that invalidates the gradually-varied flow theory, and supercritical shock waves. The objective of this work is to present a mathematical model for the undular hydraulic jump obtained from an approximate integration of the Reynolds equations for turbulent flow assuming that the Reynolds number R is high. Simple analytical solutions are presented to reveal the physics of the theory, and a numerical model is used to integrate the complete equations. The limit of application of the theory is discussed using a wave breaking condition for the inception of a surface roller. The validity of the mathematical predictions is critically assessed using physical data, thereby revealing aspects on which more research is needed

  17. Children with classic congenital adrenal hyperplasia have elevated serum leptin concentrations and insulin resistance: potential clinical implications.

    Science.gov (United States)

    Charmandari, Evangelia; Weise, Martina; Bornstein, Stefan R; Eisenhofer, Graeme; Keil, Margaret F; Chrousos, George P; Merke, Deborah P

    2002-05-01

    Leptin is secreted by the white adipose tissue and modulates energy homeostasis. Nutritional, neural, neuroendocrine, paracrine, and autocrine factors, including the sympathetic nervous system and the adrenal medulla, have been implicated in the regulation of leptin secretion. Classic congenital adrenal hyperplasia (CAH) is characterized by a defect in cortisol and aldosterone secretion, impaired development and function of the adrenal medulla, and adrenal hyperandrogenism. To examine leptin secretion in patients with classic CAH in relation to their adrenomedullary function and insulin and androgen secretion, we studied 18 children with classic CAH (12 boys and 6 girls; age range 2-12 yr) and 28 normal children (16 boys and 12 girls; age range 5-12 yr) matched for body mass index (BMI). Serum leptin concentrations were significantly higher in patients with CAH than in control subjects (8.1 +/- 2.0 vs. 2.5 +/- 0.6 ng/ml, P = 0.01), and this difference persisted when leptin values were corrected for BMI. When compared with their normal counterparts, children with CAH had significantly lower plasma epinephrine (7.1 +/- 1.3 vs. 50.0 +/- 4.2, P fasting serum insulin (10.6 +/- 1.4 vs. 3.2 +/- 0.2 microU/ml, P Insulin resistance determined by the homeostasis model assessment method was significantly greater in children with classic CAH than in normal children (2.2 +/- 0.3 vs. 0.7 +/- 0.04, P patients and controls. Gender predicted serum leptin concentrations in controls but not in patients with classic CAH. No association was found between the dose of hydrocortisone and serum leptin (r = -0.17, P = 0.5) or insulin (r = 0.24, P = 0.3) concentrations in children with CAH. Our findings indicate that children with classic CAH have elevated fasting serum leptin and insulin concentrations, and insulin resistance. These most likely reflect differences in long-term adrenomedullary hypofunction and glucocorticoid therapy. Elevated leptin and insulin concentrations in patients

  18. Contribution to solving the problem of determining the hydraulic properties of bentonite; Prispevok k rieseniu problemu stanovenia hydraulickych vlastnosti bentonitov

    Energy Technology Data Exchange (ETDEWEB)

    Dano, M.; Galambos, M. [Univerzita Komenskeho, Prirodovedecka fakulta, Katedra jadrovej chemie, 84215 Bratislava (Slovakia); Kurek, M.; Jesenak, K. [Univerzita Komenskeho, Prirodovedecka fakulta, Katedra anorganickej chemie, 84215 Bratislava (Slovakia)

    2013-04-16

    Large hydraulic resistance of clay minerals is the most used property. In this regard, bentonite is the most frequent mineral used for sealing barrier purposes in construction and building various types of waste dumps. Large hydraulic resistance of clays is often the cause of various complications of determining these properties. This report inform, how to use equipment that has been designed just for determining the hydraulic properties of particulate materials with high hydraulic resistance. It also shows its advantages and limitations in flow experiments using layers of bentonite Stara Kremnicka - Jelsovy potok. (authors)

  19. Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetes.

    Science.gov (United States)

    Nolan, Christopher J; Ruderman, Neil B; Kahn, Steven E; Pedersen, Oluf; Prentki, Marc

    2015-03-01

    Stratifying the management of type 2 diabetes (T2D) has to take into account marked variability in patient phenotype due to heterogeneity in its pathophysiology, different stages of the disease process, and multiple other patient factors including comorbidities. The focus here is on the very challenging subgroup of patients with T2D who are overweight or obese with insulin resistance (IR) and the most refractory hyperglycemia due to an inability to change lifestyle to reverse positive energy balance. For this subgroup of patients with T2D, we question the dogma that IR is primarily harmful to the body and should be counteracted at any cost. Instead we propose that IR, particularly in this high-risk subgroup, is a defense mechanism that protects critical tissues of the cardiovascular system from nutrient-induced injury. Overriding IR in an effort to lower plasma glucose levels, particularly with intensive insulin therapy, could therefore be harmful. Treatments that nutrient off-load to lower glucose are more likely to be beneficial. The concepts of "IR as an adaptive defense mechanism" and "insulin-induced metabolic stress" may provide explanation for some of the unexpected outcomes of recent major clinical trials in T2D. Potential molecular mechanisms underlying these concepts; their clinical implications for stratification of T2D management, particularly in overweight and obese patients with difficult glycemic control; and future research requirements are discussed. © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

  20. Hydraulic System Design of Hydraulic Actuators for Large Butterfly Valves

    Directory of Open Access Journals (Sweden)

    Ye HUANG

    2014-09-01

    Full Text Available Hydraulic control systems of butterfly valves are presently valve-controlled and pump-controlled. Valve-controlled hydraulic systems have serious power loss and generate much heat during throttling. Pump-controlled hydraulic systems have no overflow or throttling losses but are limited in the speed adjustment of the variable-displacement pump, generate much noise, pollute the environment, and have motor power that does not match load requirements, resulting in low efficiency under light loads and wearing of the variable-displacement pump. To overcome these shortcomings, this article designs a closed hydraulic control system in which an AC servo motor drives a quantitative pump that controls a spiral swinging hydraulic cylinder, and analyzes and calculates the structure and parameters of a spiral swinging hydraulic cylinder. The hydraulic system adjusts the servo motor’s speed according to the requirements of the control system, and the motor power matches the power provided to components, thus eliminating the throttling loss of hydraulic circuits. The system is compact, produces a large output force, provides stable transmission, has a quick response, and is suitable as a hydraulic control system of a large butterfly valve.

  1. Hydraulic characteristics of HANARO fuel bundles

    Energy Technology Data Exchange (ETDEWEB)

    Cho, S.; Chung, H. J.; Chun, S. Y.; Yang, S. K.; Chung, M. K. [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1997-12-31

    This paper presents the hydraulic characteristics measured by using LDV (Laser Doppler Velocimetry) in subchannels of HANARO, KAERI research reactor, fuel bundle. The fuel bundle consists of 18 axially finned rods with 3 spacer grids, which are arranged in cylindrical configuration. The effects of the spacer grids on the turbulent flow were investigated by the experimental results. Pressure drops for each component of the fuel bundle were measured, and the friction factors of fuel bundle and loss coefficients for the spacer grids were estimated from the measured pressure drops. Implications regarding the turbulent thermal mixing were discussed. Vibration test results measured by using laser vibrometer were presented. 9 refs., 12 figs. (Author)

  2. Hydraulic characteristics of HANARO fuel bundles

    Energy Technology Data Exchange (ETDEWEB)

    Cho, S; Chung, H J; Chun, S Y; Yang, S K; Chung, M K [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1998-12-31

    This paper presents the hydraulic characteristics measured by using LDV (Laser Doppler Velocimetry) in subchannels of HANARO, KAERI research reactor, fuel bundle. The fuel bundle consists of 18 axially finned rods with 3 spacer grids, which are arranged in cylindrical configuration. The effects of the spacer grids on the turbulent flow were investigated by the experimental results. Pressure drops for each component of the fuel bundle were measured, and the friction factors of fuel bundle and loss coefficients for the spacer grids were estimated from the measured pressure drops. Implications regarding the turbulent thermal mixing were discussed. Vibration test results measured by using laser vibrometer were presented. 9 refs., 12 figs. (Author)

  3. Extended geothermal potential of clastic aquifers by hydraulic stimulation

    NARCIS (Netherlands)

    Veldkamp, J.G.; Pluymaekers, M.P.D.; Wees, J.D.A.M.

    2014-01-01

    We evaluated the implications of hydraulic stimulation in a Dutch context for low permeability clastic aquifers at a depth of 2000 to 4000 m, whose transmissivity has been mapped in the framework of the Dutch subsurface information system on geothermal energy in the Netherlands. For the simulation

  4. Multidrug-resistant and extensively drug-resistant tuberculosis: implications for the HIV epidemic and antiretroviral therapy rollout in South Africa.

    Science.gov (United States)

    Andrews, Jason R; Shah, N Sarita; Gandhi, Neel; Moll, Tony; Friedland, Gerald

    2007-12-01

    Drug-resistant tuberculosis (TB) is emerging as a major clinical and public health challenge in areas of sub-Saharan Africa where there is a high prevalence of human immunodeficiency virus (HIV) infection. TB drug-resistance surveillance in this region has been limited by laboratory capacity and the public health infrastructure; however, with the maturation of the HIV epidemic, the burden of drug-resistant TB is increasing rapidly. The recent discovery of large numbers of cases of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB in South Africa likely represents an unrecognized and evolving epidemic rather than sporadic, localized outbreaks. The combination of a large population of HIV-infected susceptible hosts with poor TB treatment success rates, a lack of airborne infection control, limited drug-resistance testing, and an overburdened MDR-TB treatment program provides ideal conditions for an MDR-TB and XDR-TB epidemic of unparalleled magnitude. In the present article, we review the history of drug-resistant TB in South Africa, describe its interaction with the HIV epidemic and the resultant consequences, and suggest measures necessary for controlling MDR-TB and XDR-TB in this context. A successful response to the emergence of MDR-TB and XDR-TB will necessitate increased resources for and collaboration between TB and HIV programs.

  5. The potential implications of reclaimed wastewater reuse for irrigation on the agricultural environment: The knowns and unknowns of the fate of antibiotics and antibiotic resistant bacteria and resistance genes - A review.

    Science.gov (United States)

    Christou, Anastasis; Agüera, Ana; Bayona, Josep Maria; Cytryn, Eddie; Fotopoulos, Vasileios; Lambropoulou, Dimitra; Manaia, Célia M; Michael, Costas; Revitt, Mike; Schröder, Peter; Fatta-Kassinos, Despo

    2017-10-15

    The use of reclaimed wastewater (RWW) for the irrigation of crops may result in the continuous exposure of the agricultural environment to antibiotics, antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs). In recent years, certain evidence indicate that antibiotics and resistance genes may become disseminated in agricultural soils as a result of the amendment with manure and biosolids and irrigation with RWW. Antibiotic residues and other contaminants may undergo sorption/desorption and transformation processes (both biotic and abiotic), and have the potential to affect the soil microbiota. Antibiotics found in the soil pore water (bioavailable fraction) as a result of RWW irrigation may be taken up by crop plants, bioaccumulate within plant tissues and subsequently enter the food webs; potentially resulting in detrimental public health implications. It can be also hypothesized that ARGs can spread among soil and plant-associated bacteria, a fact that may have serious human health implications. The majority of studies dealing with these environmental and social challenges related with the use of RWW for irrigation were conducted under laboratory or using, somehow, controlled conditions. This critical review discusses the state of the art on the fate of antibiotics, ARB and ARGs in agricultural environment where RWW is applied for irrigation. The implications associated with the uptake of antibiotics by plants (uptake mechanisms) and the potential risks to public health are highlighted. Additionally, knowledge gaps as well as challenges and opportunities are addressed, with the aim of boosting future research towards an enhanced understanding of the fate and implications of these contaminants of emerging concern in the agricultural environment. These are key issues in a world where the increasing water scarcity and the continuous appeal of circular economy demand answers for a long-term safe use of RWW for irrigation. Copyright © 2017 Elsevier

  6. Contamination of the Clinical Microbiology Laboratory with Vancomycin-Resistant Enterococci and Multidrug- Resistant Enterobacteriaceae: Implications for Hospital and Laboratory Workers

    Science.gov (United States)

    Collins, Susan M.; Hacek, Donna M.; Degen, Lisa A.; Wright, Marc O.; Noskin, Gary A.; Peterson, Lance R.

    2001-01-01

    We surveyed environmental surfaces in our clinical microbiology laboratory to determine the prevalence of vancomycin-resistant enterococci (VRE) and multidrug-resistant Enterobacteriaceae (MDRE) during a routine working day. From a total of 193 surfaces, VRE were present on 20 (10%) and MDRE were present on 4 (2%) of the surfaces tested. In a subsequent survey after routine cleaning, all of the 24 prior positive surfaces were found to be negative. Thus, those in the laboratory should recognize that many surfaces may be contaminated by resistant organisms during routine processing of patient specimens. PMID:11574615

  7. Hydraulic Stability of Accropode Armour

    DEFF Research Database (Denmark)

    Jensen, T.; Burcharth, H. F.; Frigaard, Peter

    The present report describes the hydraulic model tests of Accropode armour layers carried out at the Hydraulics Laboratory at Aalborg University from November 1995 through March 1996. The objective of the model tests was to investigate the hydraulic stability of Accropode armour layers...... with permeable core (crushed granite with a gradation of 5-8 mm). The outcome of this study is described in "Hydraulic Stability of Single-Layer Dolos and Accropode Armour Layers" by Christensen & Burcharth (1995). In January/February 1996, Research Assistant Thomas Jensen carried out a similar study...

  8. Geographic and Research Center Origins of Rice Resistance to Asian Planthoppers and Leafhoppers: Implications for Rice Breeding and Gene Deployment

    Directory of Open Access Journals (Sweden)

    Finbarr G. Horgan

    2017-09-01

    Full Text Available This study examines aspects of virulence to resistant rice varieties among planthoppers and leafhoppers. Using a series of resistant varieties, brown planthopper, Nilaparvata lugens, virulence was assessed in seedlings and early-tillering plants at seven research centers in South and East Asia. Virulence of the whitebacked planthopper, Sogatella furcifera, in Taiwan and the Philippines was also assessed. Phylogenetic analysis of the varieties using single-nucleotide polymorphisms (SNPs indicated a clade of highly resistant varieties from South Asia with two further South Asian clades of moderate resistance. Greenhouse bioassays indicated that planthoppers can develop virulence against multiple resistance genes including genes introgressed from wild rice species. Nilaparvata lugens populations from Punjab (India and the Mekong Delta (Vietnam were highly virulent to a range of key resistance donors irrespective of variety origin. Sogatella furcifera populations were less virulent to donors than N. lugens; however, several genes for resistance to S. furcifera are now ineffective in East Asia. A clade of International Rice Research Institute (IRRI-bred varieties and breeding lines, without identified leafhopper-resistance genes, were highly resistant to the green leafhopper, Nephotettix virescens. Routine phenotyping during breeding programs likely maintains high levels of quantitative resistance to leafhoppers. We discuss these results in the light of breeding and deploying resistant rice in Asia.

  9. Hydraulic fracturing proppants

    Directory of Open Access Journals (Sweden)

    V. P. P. de Campos

    Full Text Available Abstract Hydrocarbon reservoirs can be classified as unconventional or conventional depending on the oil and gas extraction difficulty, such as the need for high-cost technology and techniques. The hydrocarbon extraction from bituminous shale, commonly known as shale gas/oil, is performed by using the hydraulic fracturing technique in unconventional reservoirs where 95% water, 0.5% of additives and 4.5% of proppants are used. Environmental problems related to hydraulic fracturing technique and better performance/development of proppants are the current challenge faced by companies, researchers, regulatory agencies, environmentalists, governments and society. Shale gas is expected to increase USA fuel production, which triggers the development of new proppants and technologies of exploration. This paper presents a review of the definition of proppants, their types, characteristics and situation in the world market and information about manufacturers. The production of nanoscale materials such as anticorrosive and intelligent proppants besides proppants with carbon nanotubes is already carried out on a scale of tonnes per year in Belgium, Germany and Asia countries.

  10. Hydraulic jett mixing

    International Nuclear Information System (INIS)

    Ackerman, J.R.

    1989-01-01

    Efficient mixing of reactants into a waste stream has always been a problem in that there has been no mixer capable of combining all the elements of enhanced mixing into a single piece of equipment. Through the development of a mixing system for the mining industry to treat acid mine water containing heavy metals, a versatile new hydraulic jetting static mixer has been developed that has no moving parts and a clean bore with no internal components. This paper reports that the main goal of the development of the hydraulic jett mixer was to reduce the size of the tankage required for an acid mine drainage (AMD) treatment plant through development of a static mixing device that could coincidentally aerate the treatment flow. This process equipment being developed would simultaneously adjust the pH and oxidize the metals allowing formation of the hydroxide sludges required for sedimentation and removal of the metals from the treatment stream. In effect, the device eliminates two reaction tanks, the neutralization/mixing tank and the aeration tank

  11. Applied hydraulic transients

    CERN Document Server

    Chaudhry, M Hanif

    2014-01-01

    This book covers hydraulic transients in a comprehensive and systematic manner from introduction to advanced level and presents various methods of analysis for computer solution. The field of application of the book is very broad and diverse and covers areas such as hydroelectric projects, pumped storage schemes, water-supply systems, cooling-water systems, oil pipelines and industrial piping systems. Strong emphasis is given to practical applications, including several case studies, problems of applied nature, and design criteria. This will help design engineers and introduce students to real-life projects. This book also: ·         Presents modern methods of analysis suitable for computer analysis, such as the method of characteristics, explicit and implicit finite-difference methods and matrix methods ·         Includes case studies of actual projects ·         Provides extensive and complete treatment of governed hydraulic turbines ·         Presents design charts, desi...

  12. Nanocoatings for High-Efficiency Industrial Hydraulic and Tooling Systems

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-05-01

    This factsheet describes a research project whose goal is to develop degradation-resistant nano-coatings of AlMgB14 and AlMgB14– (titanium diboride) TiB2 that result in improved surface hardness and reduced friction for industrial hydraulic and tooling systems.

  13. Environmental deterioration of ancient and modern hydraulic mortars (EDAMM)

    Energy Technology Data Exchange (ETDEWEB)

    Van Balen, K.; Toumbakari, E.E.; Blanco-Varela, M.T. (and others) (eds.)

    2002-07-01

    Environmental damage to ancient and modern mortars (EDAMM) is a European Commission funded project in which three European research institutes from Belgium, Spain and Italy have been collaborating. The project has provided a better understanding of the role of environmental pollution on the deterioration of ancient and modern hydraulic mortars. Recent monuments built in the 19th and 20th century, were constructed using these types of hydraulic mortars. Increasing numbers of these monuments need restoration all over Europe. Similar hydraulic mortars have been widely used in treatments carried out during last and the present century. Tests have been carried out on the identification of historic hydraulic mortars, on the evaluation of damage on samples taken from historic buildings and on the laboratory simulations carried out to investigate damage mechanisms. Among pollutants, SO{sub 2} is the main component of pollution causing damage to hydraulic mortars. Hydraulic mortars have been identified as the most sensitive building materials because of the formation of primary and secondary damage products, such as ettringite and thaumasite. Although the important implications of these results are for the development of conservation strategies for monuments and historic buildings, they are also of great relevance to the development of sustainable construction methods as the building industry still uses these materials today.

  14. Induction of prophages by fluoroquinolones in Streptococcus pneumoniae: implications for emergence of resistance in genetically-related clones.

    Directory of Open Access Journals (Sweden)

    Elena López

    Full Text Available Antibiotic resistance in Streptococcus pneumoniae has increased worldwide by the spread of a few clones. Fluoroquinolone resistance occurs mainly by alteration of their intracellular targets, the type II DNA topoisomerases, which is acquired either by point mutation or by recombination. Increase in fluoroquinolone-resistance may depend on the balance between antibiotic consumption and the cost that resistance imposes to bacterial fitness. In addition, pneumococcal prophages could play an important role. Prophage induction by fluoroquinolones was confirmed in 4 clinical isolates by using Southern blot hybridization. Clinical isolates (105 fluoroquinolone-resistant and 160 fluoroquinolone-susceptible were tested for lysogeny by using a PCR assay and functional prophage carriage was studied by mitomycin C induction. Fluoroquinolone-resistant strains harbored fewer inducible prophages (17/43 than fluoroquinolone-susceptible strains (49/70 (P = 0.0018. In addition, isolates of clones associated with fluoroquinolone resistance [CC156 (3/25; CC63 (2/20, and CC81 (1/19], had lower frequency of functional prophages than isolates of clones with low incidence of fluoroquinolone resistance [CC30 (4/21, CC230 (5/20, CC62 (9/21, and CC180 (21/30]. Likewise, persistent strains from patients with chronic respiratory diseases subjected to fluoroquinolone treatment had a low frequency of inducible prophages (1/11. Development of ciprofloxacin resistance was tested with two isogenic strains, one lysogenic and the other non-lysogenic: emergence of resistance was only observed in the non-lysogenic strain. These results are compatible with the lysis of lysogenic isolates receiving fluoroquinolones before the development of resistance and explain the inverse relation between presence of inducible prophages and fluoroquinolone-resistance.

  15. Process of preparing hydraulic cement

    Energy Technology Data Exchange (ETDEWEB)

    1919-12-11

    A process of preparing hydraulic cement from oil shale or shale coke is characterized in that the oil shale or shale coke after the distillation is burned long and hot to liberate the usual amount of carbonic acid and then is fine ground to obtain a slow hardening hydraulic cement.

  16. Control rod drive hydraulic device

    International Nuclear Information System (INIS)

    Takekawa, Toru.

    1994-01-01

    The device of the present invention can reliably prevent a possible erroneous withdrawal of control rod driving mechanism when the pressure of a coolant line is increased by isolation operation of hydraulic control units upon periodical inspection for a BWR type reactor. That is, a coolant line is connected to the downstream of a hydraulic supply device. The coolant line is connected to a hydraulic control unit. A coolant hydraulic detection device and a pressure setting device are disposed to the coolant line. A closing signal line and a returning signal line are disposed, which connect the hydraulic supply device and a flow rate control valve for the hydraulic setting device. In the device of the present invention, even if pressure of supplied coolants is elevated due to isolation of hydraulic control units, the elevation of the hydraulic pressure can be prevented. Accordingly, reliability upon periodical reactor inspection can be improved. Further, the facility is simplified and the installation to an existent facility is easy. (I.S.)

  17. Xylem hydraulic safety margins in woody plants: coordination of stomatal control of xylem tension with hydraulic capacitance

    Science.gov (United States)

    Frederick C. Meinzer; Daniel M. Johnson; Barbara Lachenbruch; Katherine A. McCulloh; David R. Woodruff

    2009-01-01

    The xylem pressure inducing 50% loss of hydraulic conductivity due to embolism (P50) is widely used for comparisons of xylem vulnerability among species and across aridity gradients. However, despite its utility as an index of resistance to catastrophic xylem failure under extreme drought, P50 may have no special...

  18. Performance and cross-crop resistance of Cry1F-maize selected Spodoptera frugiperda on transgenic Bt cotton: implications for resistance management.

    Science.gov (United States)

    Yang, Fei; Kerns, David L; Brown, Sebe; Kurtz, Ryan; Dennehy, Tim; Braxton, Bo; Head, Graham; Huang, Fangneng

    2016-06-15

    Transgenic crops producing Bacillus thuringiensis (Bt) proteins have become a primary tool in pest management. Due to the intensive use of Bt crops, resistance of the fall armyworm, Spodoptera frugiperda, to Cry1F maize has occurred in Puerto Rico, Brazil, and some areas of the southeastern U.S. The sustainability of Bt crops faces a great challenge because the Cry1F-maize resistant S. frugiperda may also infest other Bt crops in multiple cropping ecosystems. Here we examined the survival and plant injury of a S. frugiperda population selected with Cry1F maize on three single-gene and five pyramided Bt cotton products. Larvae of Cry1F-susceptible (SS), -heterozygous (RS), and -resistant (RR) genotypes of S. frugiperda were all susceptible to the pyramided cotton containing Cry1Ac/Cry2Ab, Cry1Ac/Cry1F/Vip3A, Cry1Ab/Cry2Ae, or Cry1Ab/Cry2Ae/Vip3A, and the single-gene Cry2Ae cotton. Pyramided cotton containing Cry1Ac/Cry1F was effective against SS and RS, but not for RR. These findings show that the Cry1F-maize selected S. frugiperda can cause cross-crop resistance to other Bt crops expressing similar insecticidal proteins. Resistance management and pest management programs that utilize diversify mortality factors must be implemented to ensure the sustainability of Bt crops. This is especially important in areas where resistance to single-gene Bt crops is already widespread.

  19. The Influence of Hydraulic Fracturing on Carbon Storage Performance

    Science.gov (United States)

    Fu, Pengcheng; Settgast, Randolph R.; Hao, Yue; Morris, Joseph P.; Ryerson, Frederick J.

    2017-12-01

    Conventional principles of the design and operation of geologic carbon storage (GCS) require injecting CO2 below the caprock fracturing pressure to ensure the integrity of the storage complex. In nonideal storage reservoirs with relatively low permeability, pressure buildup can lead to hydraulic fracturing of the reservoir and caprock. While the GCS community has generally viewed hydraulic fractures as a key risk to storage integrity, a carefully designed stimulation treatment under appropriate geologic conditions could provide improved injectivity while maintaining overall seal integrity. A vertically contained hydraulic fracture, either in the reservoir rock or extending a limited height into the caprock, provides an effective means to access reservoir volume far from the injection well. Employing a fully coupled numerical model of hydraulic fracturing, solid deformation, and matrix fluid flow, we study the enabling conditions, processes, and mechanisms of hydraulic fracturing during CO2 injection. A hydraulic fracture's pressure-limiting behavior dictates that the near-well fluid pressure is only slightly higher than the fracturing pressure of the rock and is insensitive to injection rate and mechanical properties of the formation. Although a fracture contained solely within the reservoir rock with no caprock penetration, would be an ideal scenario, poroelastic principles dictate that sustaining such a fracture could lead to continuously increasing pressure until the caprock fractures. We also investigate the propagation pattern and injection pressure responses of a hydraulic fracture propagating in a caprock subjected to heterogeneous in situ stress. The results have important implications for the use of hydraulic fracturing as a tool for managing storage performance.

  20. Hydraulically centered control rod

    International Nuclear Information System (INIS)

    Horlacher, W.R.; Sampson, W.T.; Schukei, G.E.

    1981-01-01

    A control rod suspended to reciprocate in a guide tube of a nuclear fuel assembly has a hydraulic bearing formed at its lower tip. The bearing includes a plurality of discrete pockets on its outer surface into which a flow of liquid is continuously provided. In one embodiment the flow is induced by the pressure head in a downward facing chamber at the end of the bearing. In another embodiment the flow originates outside the guide tube. In both embodiments the flow into the pockets produces pressure differences across the bearing which counteract forces tending to drive the rod against the guide tube wall. Thus contact of the rod against the guide tube is avoided

  1. Equipment for hydraulic testing

    International Nuclear Information System (INIS)

    Jacobsson, L.; Norlander, H.

    1981-07-01

    Hydraulic testing in boreholes is one major task of the hydrogeological program in the Stripa Project. A new testing equipment for this purpose was constructed. It consists of a downhole part and a surface part. The downhole part consists of two packers enclosing two test-sections when inflated; one between the packers and one between the bottom packer and the bottom of the borehole. A probe for downhole electronics is also included in the downhole equipment together with electrical cable and nylon tubing. In order to perform shut-in and pulse tests with high accuracy a surface controlled downhole valve was constructed. The surface equipment consists of the data acquisition system, transducer amplifier and surface gauges. In the report detailed descriptions of each component in the whole testing equipment are given. (Auth.)

  2. The Emerging Role of Extracellular Vesicle-Mediated Drug Resistance in Cancers: Implications in Advanced Prostate Cancer.

    Science.gov (United States)

    Soekmadji, Carolina; Nelson, Colleen C

    2015-01-01

    Emerging evidence has shown that the extracellular vesicles (EVs) regulate various biological processes and can control cell proliferation and survival, as well as being involved in normal cell development and diseases such as cancers. In cancer treatment, development of acquired drug resistance phenotype is a serious issue. Recently it has been shown that the presence of multidrug resistance proteins such as Pgp-1 and enrichment of the lipid ceramide in EVs could have a role in mediating drug resistance. EVs could also mediate multidrug resistance through uptake of drugs in vesicles and thus limit the bioavailability of drugs to treat cancer cells. In this review, we discussed the emerging evidence of the role EVs play in mediating drug resistance in cancers and in particular the role of EVs mediating drug resistance in advanced prostate cancer. The role of EV-associated multidrug resistance proteins, miRNA, mRNA, and lipid as well as the potential interaction(s) among these factors was probed. Lastly, we provide an overview of the current available treatments for advanced prostate cancer, considering where EVs may mediate the development of resistance against these drugs.

  3. Geographic and research center origins of rice resistance to asian planthoppers and leafhoppers: implications for rice breeding and gene deployment

    NARCIS (Netherlands)

    Horgan, F.G.; Srinivasan, Thanga Suja; Bentur, Jagadish S.; Kumar, R.; Bhanu, K.V.; Singh Sarao, Preetinder; Chien, Ho Van; Almazan, M.L.P.; Bernal, Carmencita C.; Ramal, Angelee Fame; Ferrater, J.B.; Huang, Shou Horng

    2017-01-01

    This study examines aspects of virulence to resistant rice varieties among planthoppers and leafhoppers. Using a series of resistant varieties, brown planthopper, Nilaparvata lugens, virulence was assessed in seedlings and early-tillering plants at seven research centers in South and East Asia.

  4. Coordination of stem and leaf hydraulic conductance in southern California shrubs: a test of the hydraulic segmentation hypothesis.

    Science.gov (United States)

    Pivovaroff, Alexandria L; Sack, Lawren; Santiago, Louis S

    2014-08-01

    Coordination of water movement among plant organs is important for understanding plant water use strategies. The hydraulic segmentation hypothesis (HSH) proposes that hydraulic conductance in shorter lived, 'expendable' organs such as leaves and longer lived, more 'expensive' organs such as stems may be decoupled, with resistance in leaves acting as a bottleneck or 'safety valve'. We tested the HSH in woody species from a Mediterranean-type ecosystem by measuring leaf hydraulic conductance (Kleaf) and stem hydraulic conductivity (KS). We also investigated whether leaves function as safety valves by relating Kleaf and the hydraulic safety margin (stem water potential minus the water potential at which 50% of conductivity is lost (Ψstem-Ψ50)). We also examined related plant traits including the operating range of water potentials, wood density, leaf mass per area, and leaf area to sapwood area ratio to provide insight into whole-plant water use strategies. For hydrated shoots, Kleaf was negatively correlated with KS , supporting the HSH. Additionally, Kleaf was positively correlated with the hydraulic safety margin and negatively correlated with the leaf area to sapwood area ratio. Consistent with the HSH, our data indicate that leaves may act as control valves for species with high KS , or a low safety margin. This critical role of leaves appears to contribute importantly to plant ecological specialization in a drought-prone environment. © 2014 The Authors. New Phytologist © 2014 New Phytologist Trust.

  5. VARIATION IN RESISTIVE FORCE SELECTION DURING BRIEF HIGH INTENSITY CYCLE ERGOMETRY: IMPLICATIONS FOR POWER ASSESSMENT AND PRODUCTION IN ELITE KARATE PRACTITIONERS

    Directory of Open Access Journals (Sweden)

    Julien Steven Baker

    2006-07-01

    Full Text Available The purpose of this study was to measure power values generated in elite karate fighters during brief high intensity cycle ergometry when resistive forces were derived from total - body mass (TBM or fat - free mass (FFM. Male international karate practitioners volunteered as participants (n = 11. Body density was calculated using hydrostatic weighing procedures with fat mass ascertained from body density values. Participants were required to pedal maximally on a cycle ergometer (Monark 864 against randomly assigned loads ranging from 70 g·kg-1 - 95 g·kg-1 (using a TBM or FFM protocol for 8 seconds. The resistive force that produced the highest peak power output (PPO for each protocol was considered optimal. Differences (p 0.05 were observed between time to PPO, or heart rate when the TBM and FFM protocols were compared. The findings of this study suggest that when high intensity cycle ergometer resistive forces are derived from FFM, greater peak powers can be obtained consistently in karate athletes. Resistive forces that relate to the active muscle tissue utilised during this type of exercise may need to be explored in preference to protocols that include both lean and fat masses. The findings have implications for both exercise prescription and the evaluation of experimental results concerning karate athletes

  6. Downregulation of miR-451 in Tunisian chronic myeloid leukemia patients: potential implication in imatinib resistance.

    Science.gov (United States)

    Soltani, Ismael; Douzi, Kais; Gharbi, Hanen; Benhassine, Islem; Teber, Mouheb; Amouri, Hassiba; Ben Hadj Othman, Hind; Farrah, Ahlem; Ben Lakhel, Raihane; Abbes, Salem; Menif, Samia

    2017-05-01

    Resistance to imatinib has been recognized as a major challenge for the treatment of chronic myeloid leukemia (CML). Aberrant expression of miR-451 has been reported to participate in anticancer drug resistance. However, the role of miR-451 in imatinib resistance has not been investigated. The present study was undertaken to determine the expression of miR-451 in order to find a possible association between the expression of this miRNA and imatinib resistance in Tunisian CML patients. First, real-time RT-PCR was performed to identify the expression of miR-451 in peripheral leukocytes of 59 CML patients treated with imatinib. Then, bioinformatics analysis was carried out to understand the regulatory roles of miR-451 in imatinib-resistant process. Downregulated miR-451 was observed in imatinib-resistant CML cases. In silico analysis identified MYC as a potential target of miR-451. We further revealed the existence of an MYC-binding site in MiR-451 promoter region. On the other hand, increased level of MYC was detected in imatinib-resistant CML cases which may explain the causative role of MYC in CML cases and the downregulation of miR-451. Taken together, our findings suggest that miR-451 and MYC form together a regulatory loop which may act as a potential therapeutic target, and disruption of suggested regulatory loop could help to improve CML therapy.

  7. Hydraulic Actuators with Autonomous Hydraulic Supply for the Mainline Aircrafts

    Directory of Open Access Journals (Sweden)

    I. S. Shumilov

    2014-01-01

    Full Text Available Applied in the aircraft control systems, hydraulic servo actuators with autonomous hydraulic supply, so-called, hydraulic actuators of integrated configuration, i.e. combination of a source of hydraulic power and its load in the single unit, are aimed at increasing control system reliability both owing to elimination of the pipelines connecting the actuator to the hydraulic supply source, and owing to avoidance of influence of other loads failure on the actuator operability. Their purpose is also to raise control system survivability by eliminating the long pipeline communications and their replacing for the electro-conductive power supply system, thus reducing the vulnerability of systems. The main reason for a delayed application of the hydraulic actuators in the cutting-edge aircrafts was that such aircrafts require hydraulic actuators of considerably higher power with considerable heat releases, which caused an unacceptable overheat of the hydraulic actuators. Positive and negative sides of the hydraulic actuators, their alternative options of increased reliability and survivability, local hydraulic systems as an advanced alternative to independent hydraulic actuators are considered.Now to use hydraulic actuators in mainline aircrafts is inexpedient since there are the unfairly large number of the problems reducing, first and last, safety of flights, with no essential weight and operational advantages. Still works to create competitive hydraulic actuators ought to be continued.Application of local hydraulic systems (LHS will allow us to reduce length of pressure head and drain pipelines and mass of pipelines, as well as to raise their general fail-safety and survivability. Application of the LHS principle will allow us to use a majority of steering drive advantages. It is necessary to allocate especially the following:- ease of meeting requirements for the non-local spread of the engine weight;- essentially reducing length and weight of

  8. Transmission pattern of drug-resistant tuberculosis and its implication for tuberculosis control in eastern rural China.

    Directory of Open Access Journals (Sweden)

    Yi Hu

    Full Text Available OBJECTIVE: Transmission patterns of drug-resistant Mycobacterium tuberculosis (MTB may be influenced by differences in socio-demographics, local tuberculosis (TB endemicity and efficaciousness of TB control programs. This study aimed to investigate the impact of DOTS on the transmission of drug-resistant TB in eastern rural China. METHODS: We conducted a cross-sectional study of all patients diagnosed with drug-resistant TB over a one-year period in two rural Chinese counties with varying lengths of DOTS implementation. Counties included Deqing, with over 11 years' DOTS implementation and Guanyun, where DOTS was introduced 1 year prior to start of this study. We combined demographic, clinical and epidemiologic information with IS6110-based restricted fragment length polymorphism (RFLP and Spoligotyping analysis of MTB isolates. In addition, we conducted DNA sequencing of resistance determining regions to first-line anti-tuberculosis agents. RESULTS: Of the 223 drug-resistant isolates, 73(32.7% isolates were identified with clustered IS6110RFLP patterns. The clustering proportion among total drug-resistant TB was higher in Guanyun than Deqing (26/101.vs.47/122; p,0.04, but not significantly different among the 53 multidrug-resistant isolates (10/18.vs.24/35; p,0.35. Patients with cavitary had increased risk of clustering in both counties. In Guanyun, patients with positive smear test or previous treatment history had a higher clustering proportion. Beijing genotype and isolates resistant to isoniazid and/or rifampicin were more likely to be clustered. Of the 73 patients with clustered drug-resistant isolates, 71.2% lived in the same or neighboring villages. Epidemiological link (household and social contact was confirmed in 12.3% of the clustered isolates. CONCLUSION: Transmission of drug-resistant TB in eastern rural China is characterized by small clusters and limited geographic spread. Our observations highlight the need for supplementing DOTS

  9. Geographic and research center origins of rice resistance to asian planthoppers and leafhoppers: implications for rice breeding and gene deployment

    OpenAIRE

    Horgan, F.G.; Srinivasan, Thanga Suja; Bentur, Jagadish S.; Kumar, R.; Bhanu, K.V.; Singh Sarao, Preetinder; Chien, Ho Van; Almazan, M.L.P.; Bernal, Carmencita C.; Ramal, Angelee Fame; Ferrater, J.B.; Huang, Shou Horng

    2017-01-01

    This study examines aspects of virulence to resistant rice varieties among planthoppers and leafhoppers. Using a series of resistant varieties, brown planthopper, Nilaparvata lugens, virulence was assessed in seedlings and early-tillering plants at seven research centers in South and East Asia. Virulence of the whitebacked planthopper, Sogatella furcifera, in Taiwan and the Philippines was also assessed. Phylogenetic analysis of the varieties using single-nucleotide polymorphisms (SNPs) indic...

  10. Hydraulic design of Three Gorges right bank powerhouse turbine for improvement of hydraulic stability

    International Nuclear Information System (INIS)

    Shi, Q

    2010-01-01

    This paper presents the hydraulic design of Three Gorges Right Bank Powerhouse turbine for improvement of hydraulic stability. The technical challenges faced in the hydraulic design of the turbine are given. The method of hydraulic design for improving the hydraulic stability and particularly for eliminating the upper part load pressure pulsations is clarified. The final hydraulic design results of Three Gorges Right Bank Powerhouse turbine based on modern hydraulic design techniques are presented.

  11. Hydraulic design of Three Gorges right bank powerhouse turbine for improvement of hydraulic stability

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Q, E-mail: qhshi@dfem.com.c [Dong Fang Electrical Machinery Co., Ltd., DEC 188, Huanghe West Road, Deyang, 618000 (China)

    2010-08-15

    This paper presents the hydraulic design of Three Gorges Right Bank Powerhouse turbine for improvement of hydraulic stability. The technical challenges faced in the hydraulic design of the turbine are given. The method of hydraulic design for improving the hydraulic stability and particularly for eliminating the upper part load pressure pulsations is clarified. The final hydraulic design results of Three Gorges Right Bank Powerhouse turbine based on modern hydraulic design techniques are presented.

  12. Hydraulic release oil tool

    International Nuclear Information System (INIS)

    Mims, M.G.; Mueller, M.D.; Ehlinger, J.C.

    1992-01-01

    This patent describes a hydraulic release tool. It comprises a setting assembly; a coupling member for coupling to drill string or petroleum production components, the coupling member being a plurality of sockets for receiving the dogs in the extended position and attaching the coupling member the setting assembly; whereby the setting assembly couples to the coupling member by engagement of the dogs in the sockets of releases from and disengages the coupling member in movement of the piston from its setting to its reposition in response to a pressure in the body in exceeding the predetermined pressure; and a relief port from outside the body into its bore and means to prevent communication between the relief port and the bore of the body axially of the piston when the piston is in the setting position and to establish such communication upon movement of the piston from the setting position to the release position and reduce the pressure in the body bore axially of the piston, whereby the reduction of the pressure signals that the tool has released the coupling member

  13. HYDRAULICS, SHELBY COUNTY, KENTUCKY, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydraulic data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

  14. HYDRAULICS, MEADE COUNTY, KENTUCKY, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydraulic data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

  15. The Process of Hydraulic Fracturing

    Science.gov (United States)

    Hydraulic fracturing, know as fracking or hydrofracking, produces fractures in a rock formation by pumping fluids (water, proppant, and chemical additives) at high pressure down a wellbore. These fractures stimulate the flow of natural gas or oil.

  16. Steam generator thermal-hydraulics

    International Nuclear Information System (INIS)

    Inch, W.W.; Scott, D.A.; Carver, M.B.

    1980-01-01

    This paper discusses a code for detailed numerical modelling of steam generator thermal-hydraulics, and describes related experimental programs designed to promote in-depth understanding of three-dimensional two-phase flow. (auth)

  17. In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin.

    Science.gov (United States)

    Sidhu, Amar Bir Singh; Sun, Qingan; Nkrumah, Louis J; Dunne, Michael W; Sacchettini, James C; Fidock, David A

    2007-01-26

    Azithromycin (AZ), a broad-spectrum antibacterial macrolide that inhibits protein synthesis, also manifests reasonable efficacy as an antimalarial. Its mode of action against malarial parasites, however, has remained undefined. Our in vitro investigations with the human malarial parasite Plasmodium falciparum document a remarkable increase in AZ potency when exposure is prolonged from one to two generations of intraerythrocytic growth, with AZ producing 50% inhibition of parasite growth at concentrations in the mid to low nanomolar range. In our culture-adapted lines, AZ displayed no synergy with chloroquine (CQ), amodiaquine, or artesunate. AZ activity was also unaffected by mutations in the pfcrt (P. falciparum chloroquine resistance transporter) or pfmdr1 (P. falciparum multidrug resistance-1) drug resistance loci, as determined using transgenic lines. We have selected mutant, AZ-resistant 7G8 and Dd2 parasite lines. In the AZ-resistant 7G8 line, the bacterial-like apicoplast large subunit ribosomal RNA harbored a U438C mutation in domain I. Both AZ-resistant lines revealed a G76V mutation in a conserved region of the apicoplast-encoded P. falciparum ribosomal protein L4 (PfRpl4). This protein is predicted to associate with the nuclear genome-encoded P. falciparum ribosomal protein L22 (PfRpl22) and the large subunit rRNA to form the 50 S ribosome polypeptide exit tunnel that can be occupied by AZ. The PfRpl22 sequence remained unchanged. Molecular modeling of mutant PfRpl4 with AZ suggests an altered orientation of the L75 side chain that could preclude AZ binding. These data imply that AZ acts on the apicoplast bacterial-like translation machinery and identify Pfrpl4 as a potential marker of resistance.

  18. Implications of Antibiotic Resistance for Patients' Recovery From Common Infections in the Community: A Systematic Review and Meta-analysis.

    Science.gov (United States)

    van Hecke, Oliver; Wang, Kay; Lee, Joseph J; Roberts, Nia W; Butler, Chris C

    2017-08-01

    Antibiotic use is the main driver for carriage of antibiotic-resistant bacteria. The perception exists that failure of antibiotic treatment due to antibiotic resistance has little clinical impact in the community. We searched MEDLINE, EMBASE, PubMed, Cochrane Central Register of Controlled Trials, and Web of Science from inception to 15 April 2016 without language restriction. We included studies conducted in community settings that reported patient-level data on laboratory-confirmed infections (respiratory tract, urinary tract, skin or soft tissue), antibiotic resistance, and clinical outcomes. Our primary outcome was clinical response failure. Secondary outcomes were reconsultation, further antibiotic prescriptions, symptom duration, and symptom severity. Where possible, we calculated odds ratios with 95% confidence intervals by performing meta-analysis using random effects models. We included 26 studies (5659 participants). Clinical response failure was significantly more likely in participants with antibiotic-resistant Escherichia coli urinary tract infections (odds ratio [OR] = 4.19; 95% confidence interval [CI] = 3.27-5.37; n = 2432 participants), Streptococcus pneumoniae otitis media (OR = 2.51; 95% CI = 1.29-4.88; n = 921 participants), and S. pneumoniae community-acquired pneumonia (OR = 2.15; 95% CI = 1.32-3.51; n = 916 participants). Clinical heterogeneity precluded primary outcome meta-analysis for Staphylococcus aureus skin or soft-tissue infections. Antibiotic resistance significantly impacts on patients' illness burden in the community. Patients with laboratory-confirmed antibiotic-resistant urinary and respiratory-tract infections are more likely to experience delays in clinical recovery after treatment with antibiotics. A better grasp of the risk of antibiotic resistance on outcomes that matter to patients should inform more meaningful discussions between healthcare professionals and patients about antibiotic treatment for common infections. © The

  19. 2-D Resistivity Assessment of Subsurface Characterization and its Engineering and Environmental Implications at SiLC

    Science.gov (United States)

    Nordiana, M. M.; Azwin, I. N.; Saad, Rosli; Jia, Teoh Ying; Anderson, A. B.; Tonnizam, Edy; Taqiuddin Zakaria, Muhamad

    2017-04-01

    The role of geophysics in Environmental Earth Sciences and Engineering is considered. In the developing era, geophysics has mainly contributed in investigation of new constructions such as tunnels, road, dams and high-rise buildings. This study was carried out to assess the foundation depths around a construction site in the Southern Industrial & Logistics Clusters (SiLC), Nusajaya, Johor using 2-D resistivity method. The 2-D resistivity method was carried out with a view to characterize different subsurface geological and to provide the engineering and environmental geophysical characterization of the study area. Measurements of eight 2-D resistivity profile using Pole-dipole array with 2 m minimum electrode spacing was taken with the use of ABEM Terrameter SAS4000 and ES10-64C selector. The results are presented as inversion model resistivity with the outline of the survey line. The inversion model resistivity from L1-L8 obtained is characterized by resistivity range of 1-8000 ohm-m. This range indicates the occurrence of silt, clay, sandy clay and sand whose ranges are; 10-100 ohm-m, 1-100 ohm-m, 100-800 ohm-m and 100-3000 ohm-m respectively. However, there was a boulder with range of >5000 ohm-m and saturated zone (1-20 ohm-m) which may indicate the weak zones of the study area. The 2-D resistivity method is not intended to replace borings, except in specific cases where information gathered would be sufficient to address the intended engineering and environmental purpose.

  20. Advanced Performance Hydraulic Wind Energy

    Science.gov (United States)

    Jones, Jack A.; Bruce, Allan; Lam, Adrienne S.

    2013-01-01

    The Jet Propulsion Laboratory, California Institute of Technology, has developed a novel advanced hydraulic wind energy design, which has up to 23% performance improvement over conventional wind turbine and conventional hydraulic wind energy systems with 5 m/sec winds. It also has significant cost advantages with levelized costs equal to coal (after carbon tax rebate). The design is equally applicable to tidal energy systems and has passed preliminary laboratory proof-of-performance tests, as funded by the Department of Energy.

  1. Immediate changes in estimated cardiac output and vascular resistance after 60Co exposure in monkeys: implication for performance decrement

    International Nuclear Information System (INIS)

    Bruner, A.

    1977-01-01

    Aortic blood flow velocity, blood pressure, and heart rate were recorded in 12 unanesthetized, nonperforming monkeys during exposure to 1000 rad 60 Co at 129--164 rad/min. The first postradiation changes were seen within 3--4 min of the exposure's start and included tachycardia, a transient hypotension secondary to a loss in peripheral resistance, and a brief increase followed by a decrease to subnormal levels in cardiac output. The lowest cardiac output occurred between 10 and 20 min postexposure while blood pressure and peripheral resistance were recovering. It was proposed that the concurrent combination of low cardiac output, low blood pressure, and supranormal peripheral resistance might sufficiently attenuate cerebral perfusion temporarily to account for the transient behavioral decrements often seen during this time. Histamine release was postulated as responsible for this vascular shock syndrome

  2. Monitoring hydraulic stimulation using telluric sounding

    Science.gov (United States)

    Rees, Nigel; Heinson, Graham; Conway, Dennis

    2018-01-01

    The telluric sounding (TS) method is introduced as a potential tool for monitoring hydraulic fracturing at depth. The advantage of this technique is that it requires only the measurement of electric fields, which are cheap and easy when compared with magnetotelluric measurements. Additionally, the transfer function between electric fields from two locations is essentially the identity matrix for a 1D Earth no matter what the vertical structure. Therefore, changes in the earth resulting from the introduction of conductive bodies underneath one of these sites can be associated with deviations away from the identity matrix, with static shift appearing as a galvanic multiplier at all periods. Singular value decomposition and eigenvalue analysis can reduce the complexity of the resulting telluric distortion matrix to simpler parameters that can be visualised in the form of Mohr circles. This technique would be useful in constraining the lateral extent of resistivity changes. We test the viability of utilising the TS method for monitoring on both a synthetic dataset and for a hydraulic stimulation of an enhanced geothermal system case study conducted in Paralana, South Australia. The synthetic data example shows small but consistent changes in the transfer functions associated with hydraulic stimulation, with grids of Mohr circles introduced as a useful diagnostic tool for visualising the extent of fluid movement. The Paralana electric field data were relatively noisy and affected by the dead band making the analysis of transfer functions difficult. However, changes in the order of 5% were observed from 5 s to longer periods. We conclude that deep monitoring using the TS method is marginal at depths in the order of 4 km and that in order to have meaningful interpretations, electric field data need to be of a high quality with low levels of site noise.[Figure not available: see fulltext.

  3. The revival of Phage Therapy to fight Antimicrobial Resistance – Part I: What are the legal implications?

    DEFF Research Database (Denmark)

    Minssen, Timo

    2014-01-01

    to the human organism. Despite resulting in direct negative consequences for patients, e.g. gastrointestinal disorders, these “atomic bomb” approaches can result in biological niches where resistant “bad bugs” can prosper. This is the reason why scientists are turning towards more targeted approaches...

  4. Distribution of virulence determinants among antimicrobial-resistant and antimicrobial-susceptible Escherichia coli implicated in urinary tract infections.

    Science.gov (United States)

    Stephenson, Sam; Brown, P D

    2016-01-01

    Uropathogenic Escherichia coli (UPEC) rely on the correlation of virulence expression with antimicrobial resistance to persist and cause severe urinary tract infections (UTIs). We assessed the virulence pattern and prevalence among UPEC strains susceptible and resistant to multiple antimicrobial classes. A total of 174 non-duplicate UPEC strains from patients with clinically significant UTIs were analysed for susceptibility to aminoglycoside, antifolate, cephalosporin, nitrofuran and quinolone antibiotics for the production of extended-spectrum β-lactamases and for the presence of six virulence determinants encoding adhesins (afimbrial, Type 1 fimbriae, P and S-fimbriae) and toxins (cytotoxic necrotising factor and haemolysin). Relatively high resistance rates to nalidixic acid, ciprofloxacin, cephalothin and trimethoprim-sulfamethoxazole (82%, 78%, 62% and 59%, respectively) were observed. Fourteen distinct patterns were identified for the virulence determinants such as afaBC, cnfI, fimH, hylA, papEF and sfaDE. The toxin gene, cnfI (75.3%), was the second most prevalent marker to the adhesin, fimH (97.1%). The significant association of sfaDE/hylA (P < 0.01) among antimicrobial resistant and susceptible strains was also observed notwithstanding an overall greater occurrence of virulence factors among the latter. This study provides a snapshot of UPEC complexity in Jamaica and highlights the significant clonal heterogeneity among strains. Such outcomes emphasise the need for evidence-based strategies in the effective management and control of UTIs.

  5. Frequency and distribution of the brown rust resistance gene Bru1 and implications for the Louisiana sugarcane breeding programme

    Science.gov (United States)

    Brown rust, caused by the fungus Puccinia melanocephala, is an important disease of sugarcane posing an increasing threat to sugarcane industries worldwide. A major gene, Bru1, has been shown to contribute a significant proportion of brown rust resistance in multiple sugarcane industries. The recent...

  6. Hydraulic testing in crystalline rock

    International Nuclear Information System (INIS)

    Almen, K.E.; Andersson, J.E.; Carlsson, L.; Hansson, K.; Larsson, N.A.

    1986-12-01

    Swedish Geolocical Company (SGAB) conducted and carried out single-hole hydraulic testing in borehole Fi 6 in the Finnsjoen area of central Sweden. The purpose was to make a comprehensive evaluation of different methods applicable in crystalline rocks and to recommend methods for use in current and scheduled investigations in a range of low hydraulic conductivity rocks. A total of eight different methods of testing were compared using the same equipment. This equipment was thoroughly tested as regards the elasticity of the packers and change in volume of the test section. The use of a hydraulically operated down-hole valve enabled all the tests to be conducted. Twelve different 3-m long sections were tested. The hydraulic conductivity calculated ranged from about 5x10 -14 m/s to 1x10 -6 m/s. The methods used were water injection under constant head and then at a constant rate-of-flow, each of which was followed by a pressure fall-off period. Water loss, pressure pulse, slug and drill stem tests were also performed. Interpretation was carried out using standard transient evaluation methods for flow in porous media. The methods used showed themselves to be best suited to specific conductivity ranges. Among the less time-consuming methods, water loss, slug and drill stem tests usually gave somewhat higher hydraulic conductivity values but still comparable to those obtained using the more time-consuming tests. These latter tests, however, provided supplementary information on hydraulic and physical properties and flow conditions, together with hydraulic conductivity values representing a larger volume of rock. (orig./HP)

  7. Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.

    Directory of Open Access Journals (Sweden)

    Louise V Wain

    2014-05-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is a leading cause of global morbidity and mortality and, whilst smoking remains the single most important risk factor, COPD risk is heritable. Of 26 independent genomic regions showing association with lung function in genome-wide association studies, eleven have been reported to show association with airflow obstruction. Although the main risk factor for COPD is smoking, some individuals are observed to have a high forced expired volume in 1 second (FEV1 despite many years of heavy smoking. We hypothesised that these "resistant smokers" may harbour variants which protect against lung function decline caused by smoking and provide insight into the genetic determinants of lung health. We undertook whole exome re-sequencing of 100 heavy smokers who had healthy lung function given their age, sex, height and smoking history and applied three complementary approaches to explore the genetic architecture of smoking resistance. Firstly, we identified novel functional variants in the "resistant smokers" and looked for enrichment of these novel variants within biological pathways. Secondly, we undertook association testing of all exonic variants individually with two independent control sets. Thirdly, we undertook gene-based association testing of all exonic variants. Our strongest signal of association with smoking resistance for a non-synonymous SNP was for rs10859974 (P = 2.34 × 10(-4 in CCDC38, a gene which has previously been reported to show association with FEV1/FVC, and we demonstrate moderate expression of CCDC38 in bronchial epithelial cells. We identified an enrichment of novel putatively functional variants in genes related to cilia structure and function in resistant smokers. Ciliary function abnormalities are known to be associated with both smoking and reduced mucociliary clearance in patients with COPD. We suggest that genetic influences on the development or function of cilia in the bronchial

  8. (--Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance

    Directory of Open Access Journals (Sweden)

    Eleonora Cremonini

    2018-04-01

    Full Text Available Increased permeability of the intestinal barrier is proposed as an underlying factor for obesity-associated pathologies. Consumption of high fat diets (HFD is associated with increased intestinal permeabilization and increased paracellular transport of endotoxins which can promote steatosis and insulin resistance. This study investigated whether dietary (--epicatechin (EC supplementation can protect the intestinal barrier against HFD-induced permeabilization and endotoxemia, and mitigate liver damage and insulin resistance. Mechanisms leading to loss of integrity and function of the tight junction (TJ were characterized. Consumption of a HFD for 15 weeks caused obesity, steatosis, and insulin resistance in male C57BL/6J mice. This was associated with increased intestinal permeability, decreased expression of ileal TJ proteins, and endotoxemia. Supplementation with EC (2–20 mg/kg body weight mitigated all these adverse effects. EC acted modulating cell signals and the gut hormone GLP-2, which are central to the regulation of intestinal permeability. Thus, EC prevented HFD-induced ileum NOX1/NOX4 upregulation, protein oxidation, and the activation of the redox-sensitive NF-κB and ERK1/2 pathways. Supporting NADPH oxidase as a target of EC actions, in Caco-2 cells EC and apocynin inhibited tumor necrosis alpha (TNFα-induced NOX1/NOX4 overexpression, protein oxidation and monolayer permeabilization. Together, our findings demonstrate protective effects of EC against HFD-induced increased intestinal permeability and endotoxemia. This can in part underlie EC capacity to prevent steatosis and insulin resistance occurring as a consequence of HFD consumption. Keywords: Intestinal permeability, (--Epicatechin, Steatosis, Insulin resistance, Endotoxemia, NADPH oxidase

  9. Implications Of Soil Resistivity Measurements Using The Electrical Resistivity Method A Case Study Of A Maize Farm Under Different Soil Preparation Modes At KNUST Agricultural Research Station Kumasi

    Directory of Open Access Journals (Sweden)

    Jakalia

    2015-01-01

    Full Text Available Abstract Continuous vertical electrical sounding CVES technique was used to investigate the soil moisture content of a maize farm at the Kwame Nkrumah University of Science and Technology KNUST Agricultural Research Station ARS Kumasi Ghana. The soils of the maize farm were categorized into four different land preparation modes ploughed-harrowed ploughed hoed and no-till plot. Time-lapse measurements with CVES was carried out using the multi-electrode Wenner array to investigate soil moisture variation with the help of the ABEM Terrameter SAS 4000 resistivity meter. The results showed a heterogeneous distribution of soil moisture content both spatially and temporally. Most of the water available for plants uptake was within a depth of 0.20 0.40 m which coincided with the root zones of the maize crops. In addition the no-till plot was found to conserve more moisture during dry weather conditions than the rest of the plots. The research shows that CVES technique is applicable in monitoring shallow soil water content in the field and the results obtained could be used to optimize irrigation scheduling and to assess the potential for variable-rate irrigation.

  10. Hydraulic gradients in rock aquifers

    International Nuclear Information System (INIS)

    Dahlblom, P.

    1992-05-01

    This report deals with fractured rock as a host for deposits of hazardous waste. In this context the rock, with its fractures containing moving groundwater, is called the geological barrier. The desired properties of the geological barrier are low permeability to water, low hydraulic gradients and ability to retain matter dissolved in the water. The hydraulic gradient together with the permeability and the porosity determines the migration velocity. Mathematical modelling of the migration involves calculation of the water flow and the hydrodynamic dispersion of the contaminant. The porous medium approach can be used to calculate mean flow velocities and hydrodynamic dispersion of a large number of fractures are connected, which means that a large volume have to be considered. It is assumed that the porous medium approach can be applied, and a number of idealized examples are shown. It is assumed that the groundwater table is replenished by percolation at a constant rate. One-dimensional analytical calculations show that zero hydraulic gradients may exist at relatively large distance from the coast. Two-dimensional numerical calculations show that it may be possible to find areas with low hydraulic gradients and flow velocities within blocks surrounded by areas with high hydraulic conductivity. (au)

  11. Inherent Limitations of Hydraulic Tomography

    Science.gov (United States)

    Bohling, Geoffrey C.; Butler, J.J.

    2010-01-01

    We offer a cautionary note in response to an increasing level of enthusiasm regarding high-resolution aquifer characterization with hydraulic tomography. We use synthetic examples based on two recent field experiments to demonstrate that a high degree of nonuniqueness remains in estimates of hydraulic parameter fields even when those estimates are based on simultaneous analysis of a number of carefully controlled hydraulic tests. We must, therefore, be careful not to oversell the technique to the community of practicing hydrogeologists, promising a degree of accuracy and resolution that, in many settings, will remain unattainable, regardless of the amount of effort invested in the field investigation. No practically feasible amount of hydraulic tomography data will ever remove the need to regularize or bias the inverse problem in some fashion in order to obtain a unique solution. Thus, along with improving the resolution of hydraulic tomography techniques, we must also strive to couple those techniques with procedures for experimental design and uncertainty assessment and with other more cost-effective field methods, such as geophysical surveying and, in unconsolidated formations, direct-push profiling, in order to develop methods for subsurface characterization with the resolution and accuracy needed for practical field applications. Copyright ?? 2010 The Author(s). Journal compilation ?? 2010 National Ground Water Association.

  12. Selective perceptions of hydraulic fracturing.

    Science.gov (United States)

    Sarge, Melanie A; VanDyke, Matthew S; King, Andy J; White, Shawna R

    2015-01-01

    Hydraulic fracturing (HF) is a focal topic in discussions about domestic energy production, yet the American public is largely unfamiliar and undecided about the practice. This study sheds light on how individuals may come to understand hydraulic fracturing as this unconventional production technology becomes more prominent in the United States. For the study, a thorough search of HF photographs was performed, and a systematic evaluation of 40 images using an online experimental design involving N = 250 participants was conducted. Key indicators of hydraulic fracturing support and beliefs were identified. Participants showed diversity in their support for the practice, with 47 percent expressing low support, 22 percent high support, and 31 percent undecided. Support for HF was positively associated with beliefs that hydraulic fracturing is primarily an economic issue and negatively associated with beliefs that it is an environmental issue. Level of support was also investigated as a perceptual filter that facilitates biased issue perceptions and affective evaluations of economic benefit and environmental cost frames presented in visual content of hydraulic fracturing. Results suggested an interactive relationship between visual framing and level of support, pointing to a substantial barrier to common understanding about the issue that strategic communicators should consider.

  13. Birth of a hydraulic jump

    Science.gov (United States)

    Duchesne, Alexis; Bohr, Tomas; Andersen, Anders

    2017-11-01

    The hydraulic jump, i.e., the sharp transition between a supercritical and a subcritical free-surface flow, has been extensively studied in the past centuries. However, ever since Leonardo da Vinci asked it for the first time, an important question has been left unanswered: How does a hydraulic jump form? We present an experimental and theoretical study of the formation of stationary hydraulic jumps in centimeter wide channels. Two starting situations are considered: The channel is, respectively, empty or filled with liquid, the liquid level being fixed by the wetting properties and the boundary conditions. We then change the flow-rate abruptly from zero to a constant value. In an empty channel, we observe the formation of a stationary hydraulic jump in a two-stage process: First, the channel fills by the advancing liquid front, which undergoes a transition from supercritical to subcritical at some position in the channel. Later the influence of the downstream boundary conditions makes the jump move slowly upstream to its final position. In the pre-filled channel, the hydraulic jump forms at the injector edge and then moves downstream to its final position.

  14. Implication of protein tyrosine phosphatase 1B in MCF-7 cell proliferation and resistance to 4-OH tamoxifen

    International Nuclear Information System (INIS)

    Blanquart, Christophe; Karouri, Salah-Eddine; Issad, Tarik

    2009-01-01

    The protein tyrosine phosphatase 1B (PTP1B) and the T-cell protein tyrosine phosphatase (TC-PTP) were initially thought to be mainly anti-oncogenic. However, overexpression of PTP1B and TC-PTP has been observed in human tumors, and recent studies have demonstrated that PTP1B contributes to the appearance of breast tumors by modulating ERK pathway. In the present work, we observed that decreasing the expression of TC-PTP or PTP1B in MCF-7 cells using siRNA reduced cell proliferation without affecting cell death. This reduction in proliferation was associated with decreased ERK phosphorylation. Moreover, selection of tamoxifen-resistant MCF-7 cells, by long-term culture in presence of 4-OH tamoxifen, resulted in cells that display overexpression of PTP1B and TC-PTP, and concomitant increase in ERK and STAT3 phosphorylation. siRNA experiments showed that PTP1B, but not TC-PTP, is necessary for resistance to 4-OH tamoxifen. Therefore, our work indicates that PTP1B could be a relevant therapeutic target for treatment of tamoxifen-resistant breast cancers.

  15. Implications of MicroRNAs in the Treatment of Gefitinib-Resistant Non-Small Cell Lung Cancer

    Directory of Open Access Journals (Sweden)

    Thomas K. Sin

    2016-02-01

    Full Text Available Non-small cell lung cancer (NSCLC represents about 85% of the reported cases of lung cancer. Acquired resistance to targeted therapy with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs, such as gefitinib, is not uncommon. It is thus vital to explore novel strategies to restore sensitivity to gefitinib. Provided that microRNAs (miRNAs negatively regulate their gene targets at the transcriptional level, it is speculated that miRNA mimetics may reduce the expression, activity and signal transduction of EGFR so that sensitization of tumour sites to gefitinib-induced cytotoxicity can be achieved. Indeed, a growing body of evidence has shown that the manipulation of endogenous levels of miRNA not only attenuates the EGFR/PI3K/Akt phosphorylation cascade, but also restores apoptotic cell death in in vitro models of experimentally-induced gefitinib resistance and provoked tumour regression/shrinkage in xenograft models. These data are in concordant with the clinical data showing that the differential expression profiles of miRNA in tumour tissues and blood associate strongly with drug response and overall survival. Furthermore, another line of studies indicate that the chemopreventive effects of a variety of natural compounds may involve miRNAs. The present review aims to discuss the therapeutic capacity of miRNAs in relation to recent discoveries on EGFR-TKI resistance, including chronic drug exposure and mutations.

  16. Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy.

    Directory of Open Access Journals (Sweden)

    Carl D Britto

    2018-04-01

    Full Text Available Children are substantially affected by enteric fever in most settings with a high burden of the disease, including Nepal. However pathogen population structure and transmission dynamics are poorly delineated in young children, the proposed target group for immunization programs. Here we present whole genome sequencing and antimicrobial susceptibility data on 198 S. Typhi and 66 S. Paratyphi A isolated from children aged 2 months to 15 years of age during blood culture surveillance at Patan Hospital, Nepal, 2008-2016.S. Typhi was the dominant agent and comprised several distinct genotypes, dominated by 4.3.1 (H58. The heterogeneity of genotypes in children under five was reduced compared to data from 2005-2006, attributable to ongoing clonal expansion of H58. Most isolates (86% were non-susceptible to fluoroquinolones, associated mainly with S. Typhi H58 lineage II and S. Paratyphi A harbouring mutations in the quinolone resistance-determining region (QRDR; non-susceptible strains from these groups accounted for 50% and 25% of all isolates. Multi-drug resistance (MDR was rare (3.5% of S. Typhi, 0 S. Paratyphi A and restricted to chromosomal insertions of resistance genes in H58 lineage I strains. Temporal analyses revealed a shift in dominance from H58 Lineage I to H58 Lineage II, with the latter being significantly more common after 2010. Comparison to global data sets showed the local S. Typhi and S. Paratyphi A strains had close genetic relatives in other South Asian countries, indicating regional strain circulation. Multiple imports from India of ciprofloxacin-resistant H58 lineage II strains were identified, but these were rare and showed no evidence of clonal replacement of local S. Typhi.These data indicate that enteric fever in Nepal continues to be a major public health issue with ongoing inter- and intra-country transmission, and highlights the need for regional coordination of intervention strategies. The absence of a S. Paratyphi A

  17. Broadband Magnetotelluric Investigations of Crustal Resistivity Structure in North-Eastern Alberta: Implications for Engineered Geothermal Systems

    Science.gov (United States)

    Liddell, M. V.; Unsworth, M. J.; Nieuwenhuis, G.

    2013-12-01

    Greenhouse gas emissions from hydrocarbon consumption produce profound changes in the global climate, and the implementation of alternative energy sources is needed. The oilsands industry in Alberta (Canada) is a major producer of greenhouse gases as natural gas is burnt to produce the heat required to extract and process bitumen. Geothermal energy could be utilized to provide this necessary heat and has the potential to reduce both financial costs and environmental impacts of the oilsands industry. In order to determine the geothermal potential the details of the reservoir must be understood. Conventional hydrothermal reservoirs have been detected using geophysical techniques such as magnetotellurics (MT) which measures the electrical conductivity of the Earth. However, in Northern Alberta the geothermal gradient is relatively low, and heat must be extracted from deep inside the basement rocks using Engineered Geothermal Systems (EGS) and therefore an alternative exploration technique is required. MT can be useful in this context as it can detect fracture zones and regions of elevated porosity. MT data were recorded near Fort McMurray with the goal of determining the geothermal potential by understanding the crustal resistivity structure beneath the Athabasca Oilsands. The MT data are being used to locate targets of significance for geothermal exploration such as regions of low resistivity in the basement rocks which can relate to in situ fluids or fracture zones which can facilitate efficient heat extraction or het transport. A total of 93 stations were collected ~500m apart on two profiles stretching 30 and 20km respectively. Signals were recorded using Phoenix Geophysics V5-2000 systems over frequency bands from 1000 to 0.001 Hz, corresponding to depths of penetration approximately 50m to 50km. Groom-Bailey tensor decomposition and phase tensor analysis shows a well defined geoelectric strike direction that varied along the profile from N60°E to N45

  18. Advantages of Oscillatory Hydraulic Tomography

    Science.gov (United States)

    Kitanidis, P. K.; Bakhos, T.; Cardiff, M. A.; Barrash, W.

    2012-12-01

    Characterizing the subsurface is significant for most hydrogeologic studies, such as those involving site remediation and groundwater resource explo¬ration. A variety of hydraulic and geophysical methods have been developed to estimate hydraulic conductivity and specific storage. Hydraulic methods based on the analysis of conventional pumping tests allow the estimation of conductivity and storage without need for approximate petrophysical relations, which is an advantage over most geophysical methods that first estimate other properties and then infer values of hydraulic parameters. However, hydraulic methods have the disadvantage that the head-change signal decays with distance from the pumping well and thus becomes difficult to separate from noise except in close proximity to the source. Oscillatory hydraulic tomography (OHT) is an emerging technology to im¬age the subsurface. This method utilizes the idea of imposing sinusoidally varying pressure or discharge signals at several points, collecting head observations at several other points, and then processing these data in a tomographic fashion to estimate conductivity and storage coefficients. After an overview of the methodology, including a description of the most important potential advantages and challenges associated with this approach, two key promising features of the approach will be discussed. First, the signal at an observation point is orthogonal to and thus can be separated from nuisance inputs like head fluctuation from production wells, evapotranspiration, irrigation, and changes in the level of adjacent streams. Second, although the signal amplitude may be weak, one can extract the phase and amplitude of the os¬cillatory signal by collecting measurements over a longer time, thus compensating for the effect of large distance through longer sampling period.

  19. Water hydraulic applications in hazardous environments

    International Nuclear Information System (INIS)

    Siuko, M.; Koskinen, K.T.; Vilenius, M.J.

    1996-01-01

    Water hydraulic technology provides several advantages for devices operating in critical environment. Though water hydraulics has traditionally been used in very rough applications, gives recent strong development of components possibility to build more sophisticated applications and devices with similar capacity and control properties than those of oil hydraulics without the disadvantages of oil hydraulic systems. In this paper, the basic principles, possibilities and advantages of water hydraulics are highlighted, some of the most important design considerations are presented and recent developments of water hydraulic technology are presented. Also one interesting application area, ITER fusion reactor remote handling devices, are discussed. (Author)

  20. Hydraulic lifter for an underwater drilling rig

    Energy Technology Data Exchange (ETDEWEB)

    Garan' ko, Yu L

    1981-01-15

    A hydraulic lifter is suggested for an underwater drilling rig. It includes a base, hydraulic cylinders for lifting the drilling pipes connected to the clamp holder and hydraulic distributor. In order to simplify the design of the device, the base is made with a hollow chamber connected to the rod cavities and through the hydraulic distributor to the cavities of the hydraulic cylinders for lifting the drilling pipes. The hydraulic distributor is connected to the hydrosphere through the supply valve with control in time or by remote control. The base is equipped with reverse valves whose outlets are on the support surface of the base.

  1. Hydraulic lifter of a drilling unit

    Energy Technology Data Exchange (ETDEWEB)

    Velikovskiy, L S; Demin, A V; Shadchinov, L M

    1979-01-08

    The invention refers to drilling equipment, in particular, devices for lowering and lifting operations during drilling. A hydraulic lifter of the drilling unit is suggested which contains a hydraulic cylinder, pressure line and hollow plunger whose cavities are hydraulically connected. In order to improve the reliability of the hydraulic lifter by balancing the forces of compression in the plunger of the hydraulic cylinder, a closed vessel is installed inside the plunger and rigidly connected to its ends. Its cavity is hydraulically connected to the pressure line.

  2. Controls of Hydraulic Wind Turbine

    Directory of Open Access Journals (Sweden)

    Zhang Yin

    2016-01-01

    Full Text Available In this paper a hydraulic wind turbine generator system was proposed based on analysis the current wind turbines technologies. The construction and principles were introduced. The mathematical model was verified using MATLAB and AMsim. A displacement closed loop of swash plate of motor and a speed closed loop of generator were setup, a PID control is introduced to maintain a constant speed and fixed frequency at wind turbine generator. Simulation and experiment demonstrated that the system can connect grid to generate electric and enhance reliability. The control system demonstrates a high performance speed regulation and effectiveness. The results are great significant to design a new type hydraulic wind turbine system.

  3. Endothelial function in young women with polycystic ovary syndrome (PCOS): Implications of body mass index (BMI) and insulin resistance.

    Science.gov (United States)

    El-Kannishy, Ghada; Kamal, Shaheer; Mousa, Amany; Saleh, Omayma; Badrawy, Adel El; Farahaty, Reham El; Shokeir, Tarek

    2010-01-01

    Evidence regarding endothelial function in both obese and nonobese women with PCOS is contradictory. It is unknown whether obese women with PCOS carry an increased risk related to body mass index (BMI). To identify endothelial function and investigate its relationship to body mass index and insulin resistance in young women with PCOS. Twenty-two obese women with PCOS (BMI 35.2 ± 3.2) as well as fourteen lean women (BMI 22.8 ± 2.1)with PCOS were included in the study. Fasting serum insulin, blood glucose were estimated and HOMA and Quicki index were calculated. All patients were subjected to ultrasound recording of brachial artery diameter at rest and after reactive hyperemia (FMD) for assessment of endothelial function. Ten age matched healthy females with normal BMI were chosen as a control group. There were higher basal insulin levels with lower Quicki index and higher HOMA index in women with PCOS than normal group, but the differences were significant only between obese PCOS subgroup and control. On the other hand, FMD was significantly and equally decreased in both groups of women with PCOS, compared with control subjects (3.7 ± 3.2% in the nonobese subgroup and 3.5 ± 2.8% in the obese one vs. 10.6 ± 4.1% in control subjects, P, 0.001). FMD was not correlated with BMI nor insulin resistance indices. Endothelial dysfunction is already present in young women with PCOS. In this patient group, it cannot be attributed to insulin resistance or obesity. © 2010 Asian Oceanian Association for the Study of Obesity . Published by Elsevier Ltd. All rights reserved.

  4. Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease.

    Science.gov (United States)

    Wardell, Suzanne E; Nelson, Erik R; Chao, Christina A; McDonnell, Donald P

    2013-05-01

    There is compelling evidence to suggest that drugs that function as pure estrogen receptor (ER-α) antagonists, or that downregulate the expression of ER-α, would have clinical use in the treatment of advanced tamoxifen- and aromatase-resistant breast cancer. Although such compounds are currently in development, we reasoned, based on our understanding of ER-α pharmacology, that there may already exist among the most recently developed selective estrogen receptor modulators (SERM) compounds that would have usage as breast cancer therapeutics. Thus, our objective was to identify among available SERMs those with unique pharmacologic activities and to evaluate their potential clinical use with predictive models of advanced breast cancer. A validated molecular profiling technology was used to classify clinically relevant SERMs based on their impact on ER-α conformation. The functional consequences of these observed mechanistic differences on (i) gene expression, (ii) receptor stability, and (iii) activity in cellular and animal models of advanced endocrine-resistant breast cancer were assessed. The high-affinity SERM bazedoxifene was shown to function as a pure ER-α antagonist in cellular models of breast cancer and effectively inhibited the growth of both tamoxifen-sensitive and -resistant breast tumor xenografts. Interestingly, bazedoxifene induced a unique conformational change in ER-α that resulted in its proteasomal degradation, although the latter activity was dispensable for its antagonist efficacy. Bazedoxifene was recently approved for use in the European Union for the treatment of osteoporosis and thus may represent a near-term therapeutic option for patients with advanced breast cancer. ©2013 AACR.

  5. Co-detection of Panton-Valentine Leukocidin and cotrimoxazole resistance in Staphylococcus aureus: Implications for HIV-patients' care

    Directory of Open Access Journals (Sweden)

    Christian eKraef

    2015-02-01

    Full Text Available Patients infected with the human immunodeficiency virus (HIV are frequently exposed to antimicrobial agents. This might have an impact on the resistance profile, genetic background and virulence factors of colonizing Staphylococcus aureus. Sub-Saharan Africa is considered to be endemic for Panton-Valentine leukocidin (PVL positive S. aureus which can be associated with skin and soft tissue infections. We compared S. aureus from nasal and pharyngeal swabs from HIV patients (n=141 and healthy controls (n=206 in Gabon in 2013, and analyzed determinants of colonization with PVL positive isolates in a cross-sectional study. S. aureus isolates were screened for the presence of selected virulence factors (incl. PVL and were subjected to antimicrobial susceptibility testing and genotyping. In HIV patients, S. aureus was more frequently detected (36.9 vs. 31.6% and the isolates were more frequently PVL positive than in healthy controls (42.1 vs. 23.2%. The presence of PVL was associated with cotrimoxazole resistance (OR=25.1, p<0.001 and the use of cotrimoxazole was a risk factor for colonization with PVL positive isolates (OR=2.5, p=0.06. PVL positive isolates were associated with the multilocus sequence types ST15 (OR=5.6, p<0.001 and ST152 (OR=62.1, p<0.001.Participants colonized with PVL positive isolates reported more frequently skin and soft tissue infection (SSTI in the past compared to carriers of PVL negative isolates (OR=2.7, p=0.01. In conclusion, the novelty of our study is that cotrimoxazole might increase the risk of SSTI in regions where cotrimoxazole resistance is high and associated with PVL. This finding needs to be confirmed in prospective studies.

  6. Time-wise change in neck pain in response to rehabilitation with specific resistance training: implications for exercise prescription.

    Science.gov (United States)

    Zebis, Mette K; Andersen, Christoffer H; Sundstrup, Emil; Pedersen, Mogens T; Sjøgaard, Gisela; Andersen, Lars L

    2014-01-01

    To determine the time-wise effect of specific resistance training on neck pain among industrial technicians with frequent neck pain symptoms. Secondary analysis of a parallel-group cluster randomized controlled trial of 20 weeks performed at two large industrial production units in Copenhagen, Denmark. Women with neck pain >30 mm VAS (N = 131) were included in the present analysis. The training group (N = 77) performed specific resistance training for the neck/shoulder muscles three times a week, and the control group (N = 54) received advice to stay active. Participants of both groups registered neck pain intensity (0-100 mm VAS) once a week. Neck pain intensity was 55 mm (SD 23) at baseline. There was a significant group by time interaction for neck pain (F-value 2.61, Pchange in pain showed three phases; a rapid decrease in the training group compared with the control group during the initial 7 weeks, a slower decrease in pain during the following weeks (week 8-15), and a plateau during the last weeks (week 16-20). Adherence to training followed a two-phase pattern, i.e. weekly participation rate was between 70-86% during the initial 7 weeks, dropping towards 55-63% during the latter half of the training period. Four weeks of specific resistance training reduced neck pain significantly, but 15 weeks is required to achieve maximal pain reduction. The time-wise change in pain followed a three-phase pattern with a rapid effect during the initial 7 weeks followed by a slower but still positive effect, and finally a plateau from week 15 and onwards. Decreased participation rate may explain the decreased efficacy during the latter phase of the intervention.

  7. The Intrauterine Growth Restriction Phenotype: Fetal Adaptations and Potential Implications for Later Life Insulin Resistance and Diabetes

    Science.gov (United States)

    Thorn, Stephanie R.; Rozance, Paul J.; Brown, Laura D.; Hay, William W.

    2011-01-01

    The intrauterine growth restricted (IUGR) fetus develops unique metabolic adaptations in response to exposure to reduced nutrient supply. These adaptations provide survival value for the fetus by enhancing the capacity of the fetus to take up and use nutrients, thereby reducing the need for nutrient supply. Each organ and tissue in the fetus adapts differently, with the brain showing the greatest capacity for maintaining nutrient supply and growth. Such adaptations, if persistent, also have the potential in later life to promote nutrient uptake and storage, which directly lead to complications of obesity, insulin resistance, reduced insulin production, and type 2 diabetes. PMID:21710398

  8. Electrical resistivity structures and tectonic implications of Main Karakorum Thrust (MKT) in the western Himalayas: NNE Pakistan

    Science.gov (United States)

    Shah, Syed Tallataf Hussain; Zhao, Junmeng; Xiao, Qibin; Bhatti, Zahid Imran; Khan, Nangyal Ghani; Zhang, Heng; Deng, Gong; Liu, Hongbing

    2018-06-01

    We discovered a conductive zone along Main Karakoram Thrust which could be an indication of flat subduction of Kohistan island arc beneath the Eurasian plate. Kohistan island arc collided with the Karakoram Block of the Eurasian Plate in the Early Cretaceous. However, according to findings of many researchers, the subduction ceased about 75 Ma ago. The presence of the conductive zone is an indication of current magmatism or hydrothermal fluids. Maximum low-frequency band data from Fourteen sites with recording periods of 10-2-103 s was acquired along a profile crossing MKT. Our results reveal the existence of multiple low resistivity zones beneath the region extending from shallow to the depths of more than 100 km. These low-resistivity zones might be a signature of the ongoing magmatic activities or hydrothermal fluids along the Shyok Suture Zone. In addition, we discovered another large conductive body towards the south of the study area which could be a result of uprising magmatic plumes generated by the subducting Indian plate along the Indian suture zone and their entrapment in the overlying Kohistan block.

  9. Design of hydraulic recuperation unit

    Directory of Open Access Journals (Sweden)

    Jandourek Pavel

    2016-01-01

    Full Text Available This article deals with design and measurement of hydraulic recuperation unit. Recuperation unit consist of radial turbine and axial pump, which are coupled on the same shaft. Speed of shaft with impellers are 6000 1/min. For economic reasons, is design of recuperation unit performed using commercially manufactured propellers.

  10. Tree Hydraulics: How Sap Rises

    Science.gov (United States)

    Denny, Mark

    2012-01-01

    Trees transport water from roots to crown--a height that can exceed 100 m. The physics of tree hydraulics can be conveyed with simple fluid dynamics based upon the Hagen-Poiseuille equation and Murray's law. Here the conduit structure is modelled as conical pipes and as branching pipes. The force required to lift sap is generated mostly by…

  11. Tubing Cutter is Activated Hydraulically

    Science.gov (United States)

    Mcsmith, D. G.; Richardson, J. I.

    1983-01-01

    Hydraulically-actuated tubing cutter severs tubing when operator squeezes handle grip. "Gooseneck" extension enables cutter to be used in areas where accessiblity is limited. Cutter has potential as flight-line tool and is useful in automobile and fire rescue work.

  12. Hydraulics calculation in drilling simulator

    Science.gov (United States)

    Malyugin, Aleksey A.; Kazunin, Dmitry V.

    2018-05-01

    The modeling of drilling hydraulics in the simulator system is discussed. This model is based on the previously developed quasi-steady model of an incompressible fluid flow. The model simulates the operation of all parts of the hydraulic drilling system. Based on the principles of creating a common hydraulic model, a set of new elements for well hydraulics was developed. It includes elements that correspond to the in-drillstring and annular space. There are elements controlling the inflow from the reservoir into the well and simulating the lift of gas along the annulus. New elements of the hydrosystem take into account the changing geometry of the well, loss in the bit, characteristics of the fluids including viscoplasticity. There is an opportunity specify the complications, the main one of which is gas, oil and water inflow. Correct work of models in cases of complications makes it possible to work out various methods for their elimination. The coefficients of the model are adjusted on the basis of incomplete experimental data provided by operators of drilling platforms. At the end of the article the results of modeling the elimination of gas inflow by a continuous method are presented. The values displayed in the simulator (drill pipe pressure, annulus pressure, input and output flow rates) are in good agreement with the experimental data. This exercise took one hour, which is less than the time on a real rig with the same configuration of equipment and well.

  13. Hydraulics submission for Middlesex County, NJ

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydraulics data include spatial datasets and data tables necessary for documenting the hydraulic procedures for estimating base flood elevation for a flood insurance...

  14. DCS Hydraulics Submittal, Bullock County, Alabama, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydraulics data includes spatial datasets and data tables necessary for documenting the hydraulic procedures for computing flood elevations for a flood insurance...

  15. DCS Hydraulics Submittal, Butler County, Alabama, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydraulics data includes spatial datasets and data tables necessary for documenting the hydraulic procedures for computing flood elevations for a flood insurance...

  16. DCS Hydraulics Submittal, Covington County, Alabama, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydraulics data includes spatial datasets and data tables necessary for documenting the hydraulic procedures for computing flood elevations for a flood insurance...

  17. CRITICALITY CURVES FOR PLUTONIUM HYDRAULIC FLUID MIXTURES

    International Nuclear Information System (INIS)

    WITTEKIND WD

    2007-01-01

    This Calculation Note performs and documents MCNP criticality calculations for plutonium (100% 239 Pu) hydraulic fluid mixtures. Spherical geometry was used for these generalized criticality safety calculations and three geometries of neutron reflection are: (sm b ullet)bare, (sm b ullet)1 inch of hydraulic fluid, or (sm b ullet)12 inches of hydraulic fluid. This document shows the critical volume and critical mass for various concentrations of plutonium in hydraulic fluid. Between 1 and 2 gallons of hydraulic fluid were discovered in the bottom of HA-23S. This HA-23S hydraulic fluid was reported by engineering to be Fyrquel 220. The hydraulic fluid in GLovebox HA-23S is Fyrquel 220 which contains phosphorus. Critical spherical geometry in air is calculated with 0 in., 1 in., or 12 inches hydraulic fluid reflection

  18. Hydraulics submission for Gloucester County, NJ

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydraulics data include spatial datasets and data tables necessary for documenting the hydraulic procedures for estimating base flood elevation for a flood insurance...

  19. Hydraulic characterization of " Furcraea andina

    Science.gov (United States)

    Rivera-Velasquez, M. F.; Fallico, C.; Molinari, A.; Santillan, P.; Salazar, M.

    2012-04-01

    The present level of pollution, increasingly involving groundwaters, constitutes a serious risk for environment and human health. Therefore the remediation of saturated and unsaturated soils, removing pollutant materials through innovative and economic bio-remediation techniques is more frequently required. Recent studies on natural fiber development have shown the effectiveness of these fibers for removal of some heavy metals, due to the lignin content in the natural fibers which plays an important role in the adsorption of metal cations (Lee et al., 2004; Troisi et al., 2008; C. Fallico, 2010). In the context of remediation techniques for unsaturated and/or saturated zone, an experimental approach for the hydraulic characterization of the "Furcraea andina" (i.e., Cabuya Blanca) fiber was carried out. This fiber is native to Andean regions and grows easily in wild or cultivated form in the valleys and hillsides of Colombia, Ecuador, and Peru. Fibers of "Furcraea andina" were characterized by experimental tests to determine their hydraulic conductivity or permeability and porosity in order to use this medium for bioremediation of contaminated aquifer exploiting the physical, chemical and microbial capacity of natural fiber in heavy metal adsorption. To evaluate empirically the hydraulic conductivity, laboratory tests were carried out at constant head specifically on the fibers manually extracted. For these tests we used a flow cell (used as permeameter), containing the "Furcraea andina" fibers to be characterized, suitably connected by a tygon pipe to a Marriott's bottle, which had a plastic tube that allow the adjustment of the hydraulic head for different tests to a constant value. By this experiment it was also possible to identify relationships that enable the estimation of permeability as a function of density, i.e. of the compaction degree of the fibers. Our study was carried out for three values of hydraulic head (H), namely 10, 18, and 25 cm and for each

  20. Hydraulic conductivity of rock fractures

    International Nuclear Information System (INIS)

    Zimmerman, R.W.; Bodvarsson, G.S.

    1994-10-01

    Yucca Mountain, Nevada contains numerous geological units that are highly fractured. A clear understanding of the hydraulic conductivity of fractures has been identified as an important scientific problem that must be addressed during the site characterization process. The problem of the flow of a single-phase fluid through a rough-walled rock fracture is discussed within the context of rigorous fluid mechanics. The derivation of the cubic law is given as the solution to the Navier-Stokes equations for flow between smooth, parallel plates, the only fracture geometry that is amenable to exact treatment. The various geometric and kinetic conditions that are necessary in order for the Navier-Stokes equations to be replaced by the more tractable lubrication or Hele-Shaw equations are studied and quantified. Various analytical and numerical results are reviewed pertaining to the problem of relating the effective hydraulic aperture to the statistics of the aperture distribution. These studies all lead to the conclusion that the effective hydraulic aperture is always less than the mean aperture, by a factor that depends on the ratio of the mean value of the aperture to its standard deviation. The tortuosity effect caused by regions where the rock walls are in contact with each other is studied using the Hele-Shaw equations, leading to a simple correction factor that depends on the area fraction occupied by the contact regions. Finally, the predicted hydraulic apertures are compared to measured values for eight data sets from the literature for which aperture and conductivity data were available on the same fracture. It is found that reasonably accurate predictions of hydraulic conductivity can be made based solely on the first two moments of the aperture distribution function, and the proportion of contact area. 68 refs

  1. Subsea Hydraulic Leakage Detection and Diagnosis

    OpenAIRE

    Stavenes, Thomas

    2010-01-01

    The motivation for this thesis is reduction of hydraulic emissions, minimizing of process emergency shutdowns, exploitation of intervention capacity, and reduction of costs. Today, monitoring of hydraulic leakages is scarce and the main way to detect leakage is the constant need for filling of hydraulic fluid to the Hydraulic Power Unit (HPU). Leakage detection and diagnosis has potential, which would be adressed in this thesis. A strategy towards leakage detection and diagnosis is given....

  2. Clinical implications of adipocytokines and newly emerging metabolic factors with relation to insulin resistance and cardiovascular health

    Directory of Open Access Journals (Sweden)

    Sung Hee eChoi

    2013-08-01

    Full Text Available Adipose tissue is known to secrete hormones actively and produces many biologically active proteins called adipocytokines. Typically, obesity is followed by low-grade inflammation, which is characterized by increased circulating levels of pro-inflammatory cytokines. Macrophages play a role in the inflammatory process by secreting many cytokines such as tumour necrosis factor-alpha, interleukin-6, resistin and retinol binding protein-4. These cytokines and chemokines participate in low grade pro-inflammatory processes leading to insulin resistance, metabolic impairment and cardiovascular diseases. More metabolic regulators, such as fibroblast growth factor (FGF21, FGF19, FGF1, vaspin and visfatin have now been discovered but their exact roles in human diseases are still unclear. This review focuses on recent research regarding the role of adipokines and new metabolic factors in metabolic derangement or cardiovascular disease.

  3. Fracture-resistant ultralloys for space-power systems: nuclear-thermionic-conversion implications of W,27Re

    International Nuclear Information System (INIS)

    Moraga, N.O.; Jacobsen, D.L.; Morris, J.F.

    1989-01-01

    Rhenium (Re) added to tungsten (W) improves the creep strength, recrystallization resistance and ductility. W,27Re is a good workable ultra alloy for use in space nuclear reactor (SNR) systems and perhaps its most practical processing procedure is sintering. A promising SNR application for such ultralloys is very-high-temperature thermionic energy conversion. Therefore determinations of thermionic and thermal emissive characteristics for sintered W,27Re at temperatures near and above 2000 K in hard vacuum enable both scientific and pragmatic progress. Such research results comprise the data and interpretive presentations in this paper. These findings emphasize the fallacy of characterizing ultralloys similar to W,27Re with single-valued thermophysicochemical properties - such as the work function. They further stress the necessity for investigations of this type to determine and demonstrate effective prototypic ultralloy compositions and processing methods. (author)

  4. Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.

    Science.gov (United States)

    Shibayama, Yuji; Tsukahara, Tomohide; Emori, Makoto; Murata, Kenji; Mizushima, Emi; Hirohashi, Yoshihiko; Kanaseki, Takayuki; Nakatsugawa, Munehide; Kubo, Terufumi; Yamashita, Toshihiko; Sato, Noriyuki; Torigoe, Toshihiko

    2017-09-01

    Chemotherapy has improved the prognosis of patients with sarcomas. However, it may suppress anti-tumor immunity. Recently, we reported a novel CD8 + memory T cell population with a chemo-resistance property, "young memory" T (T YM ) cells. In this study, we investigated the proportion and function of T YM cells in peripheral blood of healthy donors and sarcoma patients who received chemotherapy and those who did not. The proportion of T YM cells was significantly decreased in patients compared with that in healthy donors. In healthy donors, anti-EBV CTLs were induced using mixed lymphocyte peptide culture, from not only T YM cells but also T CM and T EM cells. No CTLs directed to tumor-associated antigens were induced. In sarcoma patients who did not receive chemotherapy, in addition to anti-EBV CTLs, CTLs directed to the tumor-associated antigen PBF were induced from T YM , T CM and T EM cells. In sarcoma patients who received chemotherapy, EBV-specific CTLs were induced from T YM cells but were hardly induced from T EM cells. Interestingly, CTLs directed to the anti-tumor-associated antigen PBF were induced from T YM cells but not from the T CM and T EM cells in sarcoma patients who received chemotherapy. The findings suggest that T YM cells are resistant to chemotherapy and can firstly recover from the nadir. T YM cells might be important for immunological memory, especially in sarcoma patients receiving chemotherapy. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

  5. Fabrication and testing of an energy-harvesting hydraulic damper

    International Nuclear Information System (INIS)

    Li, Chuan; Tse, Peter W

    2013-01-01

    Hydraulic dampers are widely used to dissipate energy during vibration damping. In this paper, an energy-harvesting hydraulic damper is proposed for collecting energy while simultaneously damping vibration. Under vibratory excitation, the flow of hydraulic oil inside the cylinder of the damper is converted into amplified rotation via a hydraulic motor, whose output shaft is connected to an electromagnetic generator capable of harvesting a large amount of energy. In this way, the vibration is damped by both oil viscosity and the operation of an electrical mechanism. An electromechanical model is presented to illustrate both the electrical and mechanical responses of the system. A three-stage identification approach is introduced to facilitate the model parameter identification using cycle-loading experiments. A prototype device is developed and characterized in a test rig. The maximum power harvested during the experiments was 435.1 W (m s −1 ) −1 , using a predefined harmonic excitation with an amplitude of 0.02 m, a frequency of 0.8 Hz, and an optimal resistance of 2 Ω. Comparison of the experimental and computational results confirmed the effectiveness of both the electromechanical model and the three-stage identification approach in realizing the proposed design. (paper)

  6. Origin of honeycombs: Testing the hydraulic and case hardening hypotheses

    Science.gov (United States)

    Bruthans, Jiří; Filippi, Michal; Slavík, Martin; Svobodová, Eliška

    2018-02-01

    Cavernous weathering (cavernous rock decay) is a global phenomenon, which occurs in porous rocks around the world. Although honeycombs and tafoni are considered to be the most common products of this complex process, their origin and evolution are as yet not fully understood. The two commonly assumed formation hypotheses - hydraulic and case hardening - were tested to elucidate the origin of honeycombs on sandstone outcrops in a humid climate. Mechanical and hydraulic properties of the lips (walls between adjacent pits) and backwalls (bottoms of pits) of the honeycombs were determined via a set of established and novel approaches. While the case hardening hypothesis was not supported by the determinations of either tensile strength, drilling resistance or porosity, the hydraulic hypothesis was clearly supported by field measurements and laboratory tests. Fluorescein dye visualization of capillary zone, vapor zone, and evaporation front upon their contact, demonstrated that the evaporation front reaches the honeycomb backwalls under low water flow rate, while the honeycomb lips remain dry. During occasional excessive water flow events, however, the evaporation front may shift to the lips, while the backwalls become moist as a part of the capillary zone. As the zone of evaporation corresponds to the zone of potential salt weathering, it is the spatial distribution of the capillary and vapor zones which dictates whether honeycombs are created or the rock surface is smoothed. A hierarchical model of factors related to the hydraulic field was introduced to obtain better insights into the process of cavernous weathering.

  7. Feeding behaviour of generalist pests on Brassica juncea: implication for manipulation of glucosinolate biosynthesis pathway for enhanced resistance.

    Science.gov (United States)

    Kumar, Pawan; Augustine, Rehna; Singh, Amarjeet Kumar; Bisht, Naveen C

    2017-10-01

    Differential accumulation of plant defence metabolites has been suggested to have important ecological consequence in the context of plant-insect interactions. Feeding of generalist pests on Brassica juncea showed a distinct pattern with selective exclusion of leaf margins which are high in glucosinolates. Molecular basis of this differential accumulation of glucosinolates could be explained based on differential expression profile of BjuMYB28 homologues, the major biosynthetic regulators of aliphatic glucosinolates, as evident from quantitative real-time PCR and promoter:GUS fusion studies in allotetraploid B. juncea. Constitutive overexpression of selected BjuMYB28 homologues enhanced accumulation of aliphatic glucosinolates in B. juncea. Performance of two generalist pests, Helicoverpa armigera and Spodoptera litura larvae, on transgenic B. juncea plants were poor compared to wild-type plants in a no-choice experiment. Correlation coefficient analysis suggested that weight gain of H. armigera larvae was negatively correlated with gluconapin (GNA) and glucobrassicanapin (GBN), whereas that of S. litura larvae was negatively correlated with GNA, GBN and sinigrin (SIN). Our study explains the significance and possible molecular basis of differential distribution of glucosinolates in B. juncea leaves and shows the potential of overexpressing BjuMYB28 for enhanced resistance of Brassica crops against the tested generalist pests. © 2017 John Wiley & Sons Ltd.

  8. Structural changes in irreversibly densified fused silica: implications for the chemical resistance of high level nuclear waste glasses

    International Nuclear Information System (INIS)

    Susman, S.; Volin, K.J.; Liebermann, R.C.; Gwanmesia, G.D.; Yanbin Wang

    1990-01-01

    Energetic photons and energetic particles create changes in the structure of nuclear waste glasses. These can be observed as changes in the average bulk physical properties. For example, exposure of fused silica to high doses of neutron bombardment leads to a maximum average compaction of 3%. However, this does not reveal the true extent of the densification that takes place at a microscopic level. Recent advances in high pressure technology have yielded large samples of fused silica which have been permanently densified under pressure and whose bulk density has been increased by 20%. These specimens have an overall structure that replicates the microstructure of a radiation damaged glass. Measurements have been made for the first time of the structural changes in this pressure densified vitreous silica using neutron diffraction and infrared absorption spectrometry. Extensive alterations in intermediate range order have been observed with consequent anticipated changes in chemical reactivity. The resistance of high level waste glasses to leaching by groundwater must be considered in light of these experimental findings. (author)

  9. Hydraulic design development of Xiluodu Francis turbine

    International Nuclear Information System (INIS)

    Wang, Y L; Li, G Y; Shi, Q H; Wang, Z N

    2012-01-01

    Hydraulic optimization design with CFD (Computational Fluid Dynamics) method, hydraulic optimization measures and model test results in the hydraulic development of Xiluodu hydropower station by DFEM (Dongfang Electric Machinery) of DEC (Dongfang Electric Corporation) of China were analyzed in this paper. The hydraulic development conditions of turbine, selection of design parameter, comparison of geometric parameters and optimization measure of turbine flow components were expatiated. And the measures of improving turbine hydraulic performance and the results of model turbine acceptance experiment were discussed in details.

  10. Database for hydraulically conductive fractures. Update 2009

    International Nuclear Information System (INIS)

    Palmen, J.; Tammisto, E.; Ahokas, H.

    2010-03-01

    Posiva flow logging (PFL) with a 0.5 m test interval and made in 10 cm steps can be used for the determination of the depth of hydraulically conductive fractures. Together with drillhole wall images and fracture data from core logging, PFL provides possibilities to detect individual conductive fractures. In this report, the results of PFL are combined with fracture data on drillholes OL-KR41 - OL-KR48, OL-KR41B - OLKR45B and pilot holes ONK-PH8 - ONK-PH10. In addition, HTU-data measured by 2 m section length and 2 m steps in holes OL-KR39 and OL-KR40 at depths 300-700 m were analyzed and combined with fracture data in a similar way. The conductive fractures were first recognised from PFL data and digital drillhole images and then the fractures from the core logging that correspond to the ones picked from the digital drillhole images were identified. The conductive fractures were primarily recognised in the images based on the openness of fractures or a visible flow in the image. In most of the cases, no tails of flow were seen in the image. In these cases the conductive fractures were recognised in the image based on the openness of fractures and a matching depth. On the basis of the results hydraulically conductive fractures/zones could in most cases be distinguished in the drillhole wall images. An important phase in the work is the calibration of the depth of the image, flow logging and the HTU logging with the sample length. In addition to results of PFL-correlation, Hydraulic Testing Unit (HTU) data measured by 2 m section length and 2 m steps was studied at selected depths for holes OL-KR39, OL-KR40, OL-KR42 and OL-KR45. Due to low HTU section depth accuracy the conducting fractures were successfully correlated with Fracture Data Base (FDB) fractures only in drillholes OL-KR39 and OL-KR40. HTU-data depth matching in these two drillholes was performed using geophysical Single Point Resistance (SPR) data both from geophysical and PFL measurements as a depth

  11. Topographic variations of water supply and plant hydraulics in a mountainous forest

    Science.gov (United States)

    Tai, X.; Mackay, D. S.; Ewers, B. E.; Parsekian, A.; Sperry, J.; Beverly, D.; Speckman, H. N.; Ohara, N.; Fantello, N.; Kelleners, T.; Fullhart, A. T.

    2017-12-01

    How plants respond to variable local water supply in complex soil-topography systems is not clear although critical. This has been attributed to a lack of integrated models that can resolve relevant hydrological and physiological mechanisms and intensive field monitoring to inform/evaluate such a model. This research addresses these knowledge gaps by leveraging a newly developed distributed plant hydraulics model, ParFlow-TREES, and detailed geophysical and physiological measurements. Observations of sap flow, leaf water potentials, micrometeorology, and electrical resistivity tomography (ERT) are combined with the model to examine the key mechanisms affecting the spatial distribution of soil water and tree water stress. Modeling results showed higher soil water condition at bottom of the hillslope on average, corroborating the ERT-derived soil moisture observations. Hydraulic traits are critical to capture the sap flux dynamics of species with contrasting leaf water potential regulation strategies and heterogeneous soil drying at different hillslope positions. These results suggested the integrated effect of topography and plants on the evolvement of soil moisture distribution. Furthermore, sensitivity analysis demonstrated the importance of using distributed observations to validate/calibrate distributed models. Focusing on lumped variables or only one particular variable might give misleading conclusions. Co-located observations improve the characterization of plant traits and local living environment, providing key information needed as a first step in resolving the form and function of the critical zone from bedrock to atmosphere. We will discuss the broader implications and potential applications of this intensive data-model comparison at other sites and greater spatial extent.

  12. Dynamic Characteristics of Communication Lines with Distributed Parameters to Control the Throttle-controlled Hydraulic Actuators

    Directory of Open Access Journals (Sweden)

    D. N. Popov

    2015-01-01

    Full Text Available The article considers a mathematical model of the hydraulic line for remote control of electro-hydraulic servo drive (EHSD with throttle control. This type of hydraulic lines is designed as a backup to replace the electrical connections, which are used to control EHSD being remote from the site with devices located to form the control signals of any object. A disadvantage of electric connections is that they are sensitive to magnetic fields and thereby do not provide the required reliability of the remote control. Hydraulic lines have no this disadvantage and therefore are used in aircraft and other industrial systems. However, dynamic characteristics of hydraulic systems still have been investigated insufficiently in the case of transmitting control signals at a distance at which the signal may be distorted when emerging the wave processes.The article results of mathematical simulation, which are verified through physical experimentation, largely eliminate the shortcomings of said information.The mathematical model described in the paper is based on the theory of unsteady pressure compressible fluids. In the model there are formulas that provide calculation of frequency characteristics of the hydraulic lines under hydraulic oscillations of the laminar flow parameters of viscous fluid.A real mock-up of the system under consideration and an experimental ad hoc unit are used to verify the results of mathematically simulated hydraulic systems.Calculated logarithmic amplitude and phase frequency characteristics compared with those obtained experimentally prove, under certain conditions, the proposed theoretical method of calculation. These conditions have to ensure compliance with initial parameters of fluid defined under stationary conditions. The applied theory takes into consideration a non-stationary hydraulic resistance of the line when calculating frequency characteristics.The scientific novelty in the article material is presented in

  13. Predator Preference for Bt-Fed Spodoptera frugiperda (Lepidoptera: Noctuidae) Prey: Implications for Insect Resistance Management in Bt Maize Seed Blends.

    Science.gov (United States)

    Svobodová, Z; Burkness, E C; Skoková Habuštová, O; Hutchison, W D

    2017-06-01

    Understanding indirect, trophic-level effects of genetically engineered plants, expressing insecticidal proteins derived from the bacterium, Bacillus thuringiensis (Bt), is essential to the ecological risk assessment process. In this study, we examine potential indirect, trophic-level effects of Bt-sensitive prey using the predator, Harmonia axyridis (Pallas), feeding upon Spodoptera frugiperda (J.E. Smith) larvae, which had delayed development (lower body mass) following ingestion of Cry1Ab maize leaves. We found no adverse effects on development and survival when H. axyridis larvae were fed S. frugiperda larvae that had fed on Cry1Ab maize tissue. Presence of Cry1Ab in H. axyridis decreased considerably after switching to another diet within 48 h. In a no-choice assay, H. axyridis larvae consumed more Bt-fed S. frugiperda than non-Bt-fed larvae. Preference for S. frugiperda feeding on Bt maize was confirmed in subsequent choice assays with H. axyridis predation on Bt-fed, 1-5-d-old S. frugiperda larvae. We suggest that H. axyridis preferred prey, not based on whether it had fed on Bt or non-Bt maize, but rather on larval mass, and they compensated for the nutritional deficiency of lighter larvae through increased consumption. Pest larvae with variable levels of resistance developing on Bt diet are often stunted versus sensitive larvae developing on non-Bt diet. It is possible that such larvae may be preferentially removed from local field populations. These results may have implications for insect resistance management and may be played out under field conditions where seed blends of Bt and non-Bt hybrids are planted. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. Advanced energy saving hydraulic elevator

    Energy Technology Data Exchange (ETDEWEB)

    Garrido, A.; Sevilleja, J.; Servia, A.

    1993-08-24

    An hydraulic elevator is described comprising: a counterweighted elevator comprising a car, a counterweight, and a rope connecting the car and the counterweight; a ram having a first reaction surface for driving one of the car or the counterweight upwardly and a second reaction surface for driving one of the car or the counterweight downwardly; multiplier means for moving the car a distance greater than a stroke of the ram, the multiplier means connecting the ram to the counterweighted elevator, the multiplier means comprising: a first pulley; a second pulley; means for rigidly connecting the first and second pulley, the means having a length corresponding to a rise of the hydraulic elevator, the means attaching to the ram; and a pulley rope which: has a first end attaching to a first fixed point, extends about the first pulley, extends about the second pulley, and has a second end attaching to a second fixed point.

  15. Model for polygonal hydraulic jumps

    DEFF Research Database (Denmark)

    Martens, Erik Andreas; Watanabe, Shinya; Bohr, Tomas

    2012-01-01

    We propose a phenomenological model for the polygonal hydraulic jumps discovered by Ellegaard and co-workers [Nature (London) 392, 767 (1998); Nonlinearity 12, 1 (1999); Physica B 228, 1 (1996)], based on the known flow structure for the type-II hydraulic jumps with a "roller" (separation eddy...... nonhydrostatic pressure contributions from surface tension in light of recent observations by Bush and co-workers [J. Fluid Mech. 558, 33 (2006); Phys. Fluids 16, S4 (2004)]. The model can be analyzed by linearization around the circular state, resulting in a parameter relationship for nearly circular polygonal...... states. A truncated but fully nonlinear version of the model can be solved analytically. This simpler model gives rise to polygonal shapes that are very similar to those observed in experiments, even though surface tension is neglected, and the condition for the existence of a polygon with N corners...

  16. Epidemiology of Methicillin-Resistant Staphylococcus aureus Diabetic Foot Infections in a Large Academic Hospital: Implications for Antimicrobial Stewardship.

    Directory of Open Access Journals (Sweden)

    Kelly R Reveles

    Full Text Available Diabetic foot infections (DFIs are the leading cause of non-traumatic lower extremity amputations in the United States. Antimicrobials active against methicillin-resistant Staphylococcus aureus (MRSA are recommended in patients with associated risk factors; however, limited data exist to support these recommendations. Due to the changing epidemiology of MRSA, and the consequences of unnecessary antibiotic therapy, guidance regarding the necessity of empirical MRSA coverage in DFIs is needed. We sought to 1 describe the prevalence of MRSA DFIs at our institution and compare to the proportion of patients who receive MRSA antibiotic coverage and 2 identify risk factors for MRSA DFI.This was a retrospective cohort study of all adult, culture-positive DFI patients managed at University Hospital, San Antonio, TX between January 1, 2010 and September 1, 2014. Patient eligibility included a principal ICD-9-CM discharge diagnosis code for foot infection and a secondary diagnosis of diabetes. The primary outcome was MRSA identified in the wound culture. Independent variables assessed included patient demographics, comorbidities, prior hospitalization, DFI therapies, prior antibiotics, prior MRSA infection, and laboratory values. Multivariable logistic regression was used to identify risk factors for MRSA DFI.Overall, 318 patients met inclusion criteria. Patients were predominantly Hispanic (79% and male (69%. Common comorbidities included hypertension (76%, dyslipidemia (52%, and obesity (49%. S. aureus was present in 46% of culture-positive DFIs (MRSA, 15%. A total of 273 patients (86% received MRSA antibiotic coverage, resulting in 71% unnecessary use. Male gender (OR 3.09, 95% CI 1.37-7.99 and bone involvement (OR 1.93, 1.00-3.78 were found to be independent risk factors for MRSA DFI.Although MRSA was the causative pathogen in a small number of DFI, antibiotic coverage targeted against MRSA was unnecessarily high.

  17. GCFR thermal-hydraulic experiments

    International Nuclear Information System (INIS)

    Schlueter, G.; Baxi, C.B.; Dalle Donne, M.; Gat, U.; Fenech, H.; Hanson, D.; Hudina, M.

    1980-01-01

    The thermal-hydraulic experimental studies performed and planned for the Gas-Cooled Fast Reactor (GCFR) core assemblies are described. The experiments consist of basic studies performed to obtain correlations, and bundle experiments which provide input for code validation and design verification. These studies have been performed and are planned at European laboratories, US national laboratories, Universities in the US, and at General Atomic Company

  18. Hysteresis phenomena in hydraulic measurement

    International Nuclear Information System (INIS)

    Ran, H J; Farhat, M; Luo, X W; Chen, Y L; Xu, H Y

    2012-01-01

    Hysteresis phenomena demonstrate the lag between the generation and the removal of some physical phenomena. This paper studies the hysteresis phenomena of the head-drop in a scaled model pump turbine using experiment test and CFD methods. These lag is induced by complicated flow patterns, which influenced the reliability of rotating machine. Keeping the same measurement procedure is concluded for the hydraulic machine measurement.

  19. Computing in Hydraulic Engineering Education

    Science.gov (United States)

    Duan, J. G.

    2011-12-01

    Civil engineers, pioneers of our civilization, are rarely perceived as leaders and innovators in modern society because of retardations in technology innovation. This crisis has resulted in the decline of the prestige of civil engineering profession, reduction of federal funding on deteriorating infrastructures, and problems with attracting the most talented high-school students. Infusion of cutting-edge computer technology and stimulating creativity and innovation therefore are the critical challenge to civil engineering education. To better prepare our graduates to innovate, this paper discussed the adaption of problem-based collaborative learning technique and integration of civil engineering computing into a traditional civil engineering curriculum. Three interconnected courses: Open Channel Flow, Computational Hydraulics, and Sedimentation Engineering, were developed with emphasis on computational simulations. In Open Channel flow, the focuses are principles of free surface flow and the application of computational models. This prepares students to the 2nd course, Computational Hydraulics, that introduce the fundamental principles of computational hydraulics, including finite difference and finite element methods. This course complements the Open Channel Flow class to provide students with in-depth understandings of computational methods. The 3rd course, Sedimentation Engineering, covers the fundamentals of sediment transport and river engineering, so students can apply the knowledge and programming skills gained from previous courses to develop computational models for simulating sediment transport. These courses effectively equipped students with important skills and knowledge to complete thesis and dissertation research.

  20. Control rod driving hydraulic device

    International Nuclear Information System (INIS)

    Sugano, Hiroshi.

    1993-01-01

    In a control rod driving hydraulic device for an improved BWR type reactor, a bypass pipeline is disposed being branched from a scram pipeline, and a control orifice and a throttle valve are interposed to the bypass pipeline for restricting pressure. Upon occurrence of scram, about 1/2 of water quantity flowing from an accumulator of a hydraulic control unit to the lower surface of a piston of control rod drives by way of a scram pipeline is controlled by the restricting orifice and the throttle valve, by which the water is discharged to a pump suction pipeline or other pipelines by way of the bypass pipeline. With such procedures, a function capable of simultaneously conducting scram for two control rod drives can be attained by one hydraulic control unit. Further, an excessive peak pressure generated by a water hammer phenomenon in the scram pipeline or the control rod drives upon occurrence of scram can be reduced. Deformation and failure due to the excessive peak pressure can be prevented, as well as vibrations and degradation of performance of relevant portions can be prevented. (N.H.)

  1. Novel evaporation experiment to determine soil hydraulic properties

    Directory of Open Access Journals (Sweden)

    K. Schneider

    2006-01-01

    Full Text Available A novel experimental approach to determine soil hydraulic material properties for the dry and very dry range is presented. Evaporation from the surface of a soil column is controlled by a constant flux of preconditioned air and the resulting vapour flux is measured by infrared absorption spectroscopy. The data are inverted under the assumptions that (i the simultaneous movement of water in the liquid and vapour is represented by Richards' equation with an effective hydraulic conductivity and that (ii the coupling between the soil and the well-mixed atmosphere can be modelled by a boundary layer with a constant transfer resistance. The optimised model fits the data exceptionally well. Remaining deviations during the initial phase of an experiment are thought to be well-understood and are attributed to the onset of the heat flow through the column which compensates the latent heat of evaporation.

  2. Hydraulic limits preceding mortality in a piñon-juniper woodland under experimental drought.

    Science.gov (United States)

    Plaut, Jennifer A; Yepez, Enrico A; Hill, Judson; Pangle, Robert; Sperry, John S; Pockman, William T; McDowell, Nate G

    2012-09-01

    Drought-related tree mortality occurs globally and may increase in the future, but we lack sufficient mechanistic understanding to accurately predict it. Here we present the first field assessment of the physiological mechanisms leading to mortality in an ecosystem-scale rainfall manipulation of a piñon-juniper (Pinus edulis-Juniperus monosperma) woodland. We measured transpiration (E) and modelled the transpiration rate initiating hydraulic failure (E(crit) ). We predicted that isohydric piñon would experience mortality after prolonged periods of severely limited gas exchange as required to avoid hydraulic failure; anisohydric juniper would also avoid hydraulic failure, but sustain gas exchange due to its greater cavitation resistance. After 1 year of treatment, 67% of droughted mature piñon died with concomitant infestation by bark beetles (Ips confusus) and bluestain fungus (Ophiostoma spp.); no mortality occurred in juniper or in control piñon. As predicted, both species avoided hydraulic failure, but safety margins from E(crit) were much smaller in piñon, especially droughted piñon, which also experienced chronically low hydraulic conductance. The defining characteristic of trees that died was a 7 month period of near-zero gas exchange, versus 2 months for surviving piñon. Hydraulic limits to gas exchange, not hydraulic failure per se, promoted drought-related mortality in piñon pine. © 2012 Blackwell Publishing Ltd.

  3. A Hydraulic Stress Measurement System for Deep Borehole Investigations

    Science.gov (United States)

    Ask, Maria; Ask, Daniel; Cornet, Francois; Nilsson, Tommy

    2017-04-01

    Luleå University of Technology (LTU) is developing and building a wire-line system for hydraulic rock stress measurements, with funding from the Swedish Research Council and Luleå University of Technology. In this project, LTU is collaborating with University of Strasbourg and Geosigma AB. The stress state influences drilling and drillability, as well as rock mass stability and permeability. Therefore, knowledge about the state of in-situ stress (stress magnitudes, and orientations) and its spatial variation with depth is essential for many underground rock engineering projects, for example for underground storage of hazardous material (e.g. nuclear waste, carbon dioxide), deep geothermal exploration, and underground infrastructure (e.g. tunneling, hydropower dams). The system is designed to conduct hydraulic stress testing in slim boreholes. There are three types of test methods: (1) hydraulic fracturing, (2) sleeve fracturing and (3) hydraulic testing of pre-existing fractures. These are robust methods for determining in situ stresses from boreholes. Integration of the three methods allows determination of the three-dimensional stress tensor and its spatial variation with depth in a scientific unambiguously way. The stress system is composed of a downhole and a surface unit. The downhole unit consists of hydraulic fracturing equipment (straddle packers and downhole imaging tool) and their associated data acquisition systems. The testing system is state of the art in several aspects including: (1) Large depth range (3 km), (2) Ability to test three borehole dimensions (N=76 mm, H=96 mm, and P=122 mm), (3) Resistivity imager maps the orientation of tested fracture; (4) Highly stiff and resistive to corrosion downhole testing equipment; and (5) Very detailed control on the injection flow rate and cumulative volume is obtained by a hydraulic injection pump with variable piston rate, and a highly sensitive flow-meter. At EGU General Assembly 2017, we would like to

  4. Scaling Analysis of the Single-Phase Natural Circulation: the Hydraulic Similarity

    International Nuclear Information System (INIS)

    Yu, Xin-Guo; Choi, Ki-Yong

    2015-01-01

    These passive safety systems all rely on the natural circulation to cool down the reactor cores during an accident. Thus, a robust and accurate scaling methodology must be developed and employed to both assist in the design of a scaled-down test facility and guide the tests in order to mimic the natural circulation flow of its prototype. The natural circulation system generally consists of a heat source, the connecting pipes and several heat sinks. Although many applauding scaling methodologies have been proposed during last several decades, few works have been dedicated to systematically analyze and exactly preserve the hydraulic similarity. In the present study, the hydraulic similarity analyses are performed at both system and local level. By this mean, the scaling criteria for the exact hydraulic similarity in a full-pressure model have been sought. In other words, not only the system-level but also the local-level hydraulic similarities are pursued. As the hydraulic characteristics of a fluid system is governed by the momentum equation, the scaling analysis starts with it. A dimensionless integral loop momentum equation is derived to obtain the dimensionless numbers. In the dimensionless momentum equation, two dimensionless numbers, the dimensionless flow resistance number and the dimensionless gravitational force number, are identified along with a unique hydraulic time scale, characterizing the system hydraulic response. A full-height full-pressure model is also made to see which model among the full-height model and reduced-height model can preserve the hydraulic behavior of the prototype. From the dimensionless integral momentum equation, a unique hydraulic time scale, which characterizes the hydraulic response of a single-phase natural circulation system, is identified along with two dimensionless parameters: the dimensionless flow resistance number and the dimensionless gravitational force number. By satisfying the equality of both dimensionless numbers

  5. Scaling Analysis of the Single-Phase Natural Circulation: the Hydraulic Similarity

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Xin-Guo; Choi, Ki-Yong [KAERI, Daejeon (Korea, Republic of)

    2015-05-15

    These passive safety systems all rely on the natural circulation to cool down the reactor cores during an accident. Thus, a robust and accurate scaling methodology must be developed and employed to both assist in the design of a scaled-down test facility and guide the tests in order to mimic the natural circulation flow of its prototype. The natural circulation system generally consists of a heat source, the connecting pipes and several heat sinks. Although many applauding scaling methodologies have been proposed during last several decades, few works have been dedicated to systematically analyze and exactly preserve the hydraulic similarity. In the present study, the hydraulic similarity analyses are performed at both system and local level. By this mean, the scaling criteria for the exact hydraulic similarity in a full-pressure model have been sought. In other words, not only the system-level but also the local-level hydraulic similarities are pursued. As the hydraulic characteristics of a fluid system is governed by the momentum equation, the scaling analysis starts with it. A dimensionless integral loop momentum equation is derived to obtain the dimensionless numbers. In the dimensionless momentum equation, two dimensionless numbers, the dimensionless flow resistance number and the dimensionless gravitational force number, are identified along with a unique hydraulic time scale, characterizing the system hydraulic response. A full-height full-pressure model is also made to see which model among the full-height model and reduced-height model can preserve the hydraulic behavior of the prototype. From the dimensionless integral momentum equation, a unique hydraulic time scale, which characterizes the hydraulic response of a single-phase natural circulation system, is identified along with two dimensionless parameters: the dimensionless flow resistance number and the dimensionless gravitational force number. By satisfying the equality of both dimensionless numbers

  6. Experimental study of the pressure discharge process for the hydraulic control rod drive system stepped cylinder

    International Nuclear Information System (INIS)

    Wang, Jinhua; Bo, Hanliang; Zheng, Wenxiang

    2002-01-01

    The pressure discharge process from the stepped cylinder of the Hydraulic Control Rod Drive System (HCRDS) was studied experimentally in the HCRDS experimental loop for the 200 MW Nuclear Heating Reactor (NHR-200). The results showed that the differential pressure between the outside and the inside of the stepped cylinder increased rapidly to the desired value so that the force induced by the differential pressure which pushes the out tube of stepped cylinder was large enough. Therefore, if the hydraulic control rod were jammed, the pressure could push the hydraulic control rod to overcome the frictional resistance to insert the control rod into the reactor core. The experimental results verified that this design would solve the problem of hydraulic control rod jamming during an accident. (author)

  7. Combined hydraulic and regenerative braking system

    Science.gov (United States)

    Venkataperumal, R.R.; Mericle, G.E.

    1979-08-09

    A combined hydraulic and regenerative braking system and method for an electric vehicle is disclosed. The braking system is responsive to the applied hydraulic pressure in a brake line to control the braking of the vehicle to be completely hydraulic up to a first level of brake line pressure, to be partially hydraulic at a constant braking force and partially regenerative at a linearly increasing braking force from the first level of applied brake line pressure to a higher second level of brake line pressure, to be partially hydraulic at a linearly increasing braking force and partially regenerative at a linearly decreasing braking force from the second level of applied line pressure to a third and higher level of applied line pressure, and to be completely hydraulic at a linearly increasing braking force from the third level to all higher applied levels of line pressure.

  8. Optimization of hydraulic turbine diffuser

    Directory of Open Access Journals (Sweden)

    Moravec Prokop

    2016-01-01

    Full Text Available Hydraulic turbine diffuser recovers pressure energy from residual kinetic energy on turbine runner outlet. Efficiency of this process is especially important for high specific speed turbines, where almost 50% of available head is utilized within diffuser. Magnitude of the coefficient of pressure recovery can be significantly influenced by designing its proper shape. Present paper focuses on mathematical shape optimization method coupled with CFD. First method is based on direct search Nelder-Mead algorithm, while the second method employs adjoint solver and morphing. Results obtained with both methods are discussed and their advantages/disadvantages summarized.

  9. A HISTORICAL PERSPECTIVE OF NUCLEAR THERMAL HYDRAULICS

    Energy Technology Data Exchange (ETDEWEB)

    D’Auria, F; Rohatgi, Upendra S.

    2017-01-12

    The nuclear thermal-hydraulics discipline was developed following the needs for nuclear power plants (NPPs) and, to a more limited extent, research reactors (RR) design and safety. As in all other fields where analytical methods are involved, nuclear thermal-hydraulics took benefit of the development of computers. Thermodynamics, rather than fluid dynamics, is at the basis of the development of nuclear thermal-hydraulics together with the experiments in complex two-phase situations, namely, geometry, high thermal density, and pressure.

  10. Calculation of saturated hydraulic conductivity of bentonite

    International Nuclear Information System (INIS)

    He Jun

    2006-01-01

    Hydraulic conductivity test has some defects such as weak repeatability, time-consuming. Taking bentonite as dual porous media, the calculation formula of the distance, d 2 , between montmorillonite in intraparticle pores is deduced. Improved calculated method of hydraulic conductivity is obtained using d 2 and Poiseuille law. The method is valid through the comparison with results of test and other methods. The method is very convenient to calculate hydraulic conductivity of bentonite of certain montmorillonite content and void ratio. (authors)

  11. Reactor Thermal Hydraulic Numerical Calculation And Modeling

    International Nuclear Information System (INIS)

    Duong Ngoc Hai; Dang The Ba

    2008-01-01

    In the paper the results of analysis of thermal hydraulic state models using the numerical codes such as COOLOD, EUREKA and RELAP5 for simulation of the reactor thermal hydraulic states are presented. The calculations, analyses of reactor thermal hydraulic state and safety were implemented using different codes. The received numerical results, which were compared each to other, to experiment measurement of Dalat (Vietnam) research reactor and published results, show their appropriateness and capacity for analyses of different appropriate cases. (author)

  12. Hydraulic nuts (hydranuts) for critical bolted joints

    International Nuclear Information System (INIS)

    Greenwell, S.

    2008-01-01

    HydraNuts replace the original nut and torquing equipment, combining the two functions into one system. Designed for simple installation and operation, HydraNuts are fitted to the stud bolts. Once all HydraNuts are fitted to the application, flexible hydraulic hoses are connected, forming a closed loop hydraulic harness, allowing simultaneous pressurization of all HydraNuts. Hydraulic pressure is obtained by the use of a pumping unit and the resultant load generated is transferred to the studs and flange closure is obtained. Locking rings are rotated into place, supporting the tensioned load mechanically after hydraulic pressure is released. The hose harness is removed. (author)

  13. Modeling and stability of electro-hydraulic servo of hydraulic excavator

    Science.gov (United States)

    Jia, Wenhua; Yin, Chenbo; Li, Guo; Sun, Menghui

    2017-11-01

    The condition of the hydraulic excavator is complicated and the working environment is bad. The safety and stability of the control system is influenced by the external factors. This paper selects hydraulic excavator electro-hydraulic servo system as the research object. A mathematical model and simulation model using AMESIM of servo system is established. Then the pressure and flow characteristics are analyzed. The design and optimization of electro-hydraulic servo system and its application in engineering machinery is provided.

  14. Genetic differentiation among Maruca vitrata F. (Lepidoptera: Crambidae populations on cultivated cowpea and wild host plants: implications for insect resistance management and biological control strategies.

    Directory of Open Access Journals (Sweden)

    Tolulope A Agunbiade

    Full Text Available Maruca vitrata Fabricius (Lepidoptera: Crambidae is a polyphagous insect pest that feeds on a variety of leguminous plants in the tropics and subtropics. The contribution of host-associated genetic variation on population structure was investigated using analysis of mitochondrial cytochrome oxidase 1 (cox1 sequence and microsatellite marker data from M. vitrata collected from cultivated cowpea (Vigna unguiculata L. Walp., and alternative host plants Pueraria phaseoloides (Roxb. Benth. var. javanica (Benth. Baker, Loncocarpus sericeus (Poir, and Tephrosia candida (Roxb.. Analyses of microsatellite data revealed a significant global FST estimate of 0.05 (P≤0.001. The program STRUCTURE estimated 2 genotypic clusters (co-ancestries on the four host plants across 3 geographic locations, but little geographic variation was predicted among genotypes from different geographic locations using analysis of molecular variance (AMOVA; among group variation -0.68% or F-statistics (FSTLoc = -0.01; P = 0.62. These results were corroborated by mitochondrial haplotype data (φSTLoc = 0.05; P = 0.92. In contrast, genotypes obtained from different host plants showed low but significant levels of genetic variation (FSTHost = 0.04; P = 0.01, which accounted for 4.08% of the total genetic variation, but was not congruent with mitochondrial haplotype analyses (φSTHost = 0.06; P = 0.27. Variation among host plants at a location and host plants among locations showed no consistent evidence for M. vitrata population subdivision. These results suggest that host plants do not significantly influence the genetic structure of M. vitrata, and this has implications for biocontrol agent releases as well as insecticide resistance management (IRM for M. vitrata in West Africa.

  15. Purification, biochemical characterization, and implications of an alkali-tolerant catalase from the spacecraft-associated and oxidation-resistant Acinetobacter gyllenbergii 2P01AA.

    Science.gov (United States)

    Muster, N; Derecho, I; Dallal, F; Alvarez, R; McCoy, K B; Mogul, R

    2015-04-01

    Herein, we report on the purification, characterization, and sequencing of catalase from Acinetobacter gyllenbergii 2P01AA, an extremely oxidation-resistant bacterium that was isolated from the Mars Phoenix spacecraft assembly facility. The Acinetobacter are dominant members of the microbial communities that inhabit spacecraft assembly facilities and consequently may serve as forward contaminants that could impact the integrity of future life-detection missions. Catalase was purified by using a 3-step chromatographic procedure, where mass spectrometry provided respective subunit and intact masses of 57.8 and 234.6 kDa, which were consistent with a small-subunit tetrameric catalase. Kinetics revealed an extreme pH stability with no loss in activity between pH 5 and 11.5 and provided respective kcat/Km and kcat values of ∼10(7) s(-1) M(-1) and 10(6) s(-1), which are among the highest reported for bacterial catalases. The amino acid sequence was deduced by in-depth peptide mapping, and structural homology suggested that the catalases from differing strains of A. gyllenbergii differ only at residues near the subunit interfaces, which may impact catalytic stability. Together, the kinetic, alkali-tolerant, and halotolerant properties of the catalase from A. gyllenbergii 2P01AA are significant, as they are consistent with molecular adaptations toward the alkaline, low-humidity, and potentially oxidizing conditions of spacecraft assembly facilities. Therefore, these results support the hypothesis that the selective pressures of the assembly facilities impact the microbial communities at the molecular level, which may have broad implications for future life-detection missions.

  16. Characterising the water use and hydraulic properties of riparian tree invasions: A case study of Populus canescens in South Africa

    CSIR Research Space (South Africa)

    Ntshidi, Zanele

    2018-04-01

    Full Text Available catchment of South Africa. Whole tree hydraulic resistance ranged from ~ 1.4 MPa·h·g(sup)-1 for large trees to ~14.3 MPa·h·g(sup)-1 for the small ones. These resistances are higher than those found for poplars in temperate climates, suggesting substantial...

  17. Divergent Hydraulic Safety Strategies in Three Co-occurring Anacardiaceae Tree Species in a Chinese Savanna.

    Science.gov (United States)

    Zhang, Shu-Bin; Zhang, Jiao-Lin; Cao, Kun-Fang

    2016-01-01

    Vulnerability segmentation, the condition under which plant leaves are more vulnerable to drought-induced cavitation than stems, may act as a "safety valve" to protect stems from hydraulic failure. Evergreen, winter-deciduous, and drought-deciduous tree species co-occur in tropical savannas, but there have been no direct studies on the role of vulnerability segmentation and stomatal regulation in maintaining hydraulic safety in trees with these three leaf phenologies. To this end, we selected three Anacardiaceae tree species co-occurring in a Chinese savanna, evergreen Pistacia weinmanniifolia , drought-deciduous Terminthia paniculata , and winter-deciduous Lannea coromandelica , to study inter-species differentiation in leaf and stem hydraulic safety. We found that the two deciduous species had significantly higher sapwood-specific hydraulic conductivity and leaf-specific hydraulic conductance than the evergreen species. Moreover, two deciduous species were more vulnerable to stem cavitation than the evergreen species, although both drought-deciduous species and evergreen species had drought-resistance leaves. The evergreen species maintained a wide hydraulic safety margin (HSM) in stems and leaves; which was achieved by embolism resistance of both stems and leaves and isohydric stomatal control. Both deciduous species had limited HSMs in stems and leaves, being isohydric in the winter-deciduous species and anisohydric in drought-deciduous species. The difference in water potential at 50% loss of hydraulic conductivity between the leaves and the terminal stems (P50 leaf-stem ) was positive in P. weinmanniifolia and L. coromandelica , whereas, T. paniculata exhibited a lack of vulnerability segmentation. In addition, differences in hydraulic architecture were found to be closely related to other structural traits, i.e., leaf mass per area, wood density, and sapwood anatomy. Overall, the winter-deciduous species exhibits a drought-avoidance strategy that maintains

  18. Xylem hydraulic properties of roots and stems of nine Mediterranean woody species.

    Science.gov (United States)

    Martínez-Vilalta, Jordi; Prat, Ester; Oliveras, Imma; Piñol, Josep

    2002-09-01

    We studied the hydraulic architecture and water relations of nine co-occurring woody species in a Spanish evergreen oak forest over the course of a dry season. Our main objectives were to: (1) test the existence of a trade-off between hydraulic conductivity and security in the xylem, and (2) establish the safety margins at which the species operated in relation to hydraulic failure, and compare these safety margins between species and tissues (roots vs. stems). Our results showed that the relationship between specific hydraulic conductivity (K s) and resistance to cavitation followed a power function with exponent ≈-2, consistent with the existence of a trade-off between conductivity and security in the xylem, and also consistent with a linear relationship between vessel diameter and the size of inter-vessel pores. The diameter of xylem conduits, K s and vulnerability to xylem embolism were always higher in roots than in stems of the same species. Safety margins from hydraulic failure were narrower in roots than in stems. Among species, the water potential (Ψ) at which 50% of conductivity was lost due to embolism ranged between -0.9 and Cistus albidus=Ilex aquifolium>Phillyrea latifolia>Juniperus oxycedrus. Gas exchange and seasonal Ψ minima were in general correlated with resistance to xylem embolism. Hydraulic safety margins differed markedly among species, with some of them (J. oxycedrus, I. aquifolium, P. latifolia) showing a xylem overly resistant to cavitation. We hypothesize that this overly resistant xylem may be related to the shape of the relationship between K s and security we have found.

  19. Variation of Desert Soil Hydraulic Properties with Pedogenic Maturity

    Science.gov (United States)

    Nimmo, J. R.; Perkins, K. S.; Mirus, B. B.; Schmidt, K. M.; Miller, D. M.; Stock, J. D.; Singha, K.

    2006-12-01

    Older alluvial desert soils exhibit greater pedogenic maturity, having more distinct desert pavements, vesicular (Av) horizons, and more pronounced stratification from processes such as illuviation and salt accumulation. These and related effects strongly influence the soil hydraulic properties. Older soils have been observed to have lower saturated hydraulic conductivity, and possibly greater capacity to retain water, but the quantitative effect of specific pedogenic features on the soil water retention or unsaturated hydraulic conductivity (K) curves is poorly known. With field infiltration/redistribution experiments on three different-aged soils developed within alluvial wash deposits in the Mojave National Preserve, we evaluated effective hydraulic properties over a scale of several m horizontally and to 1.5 m depth. We then correlated these properties with pedogenic features. The selected soils are (1) recently deposited sediments, (2) a soil of early Holocene age, and (3) a highly developed soil of late Pleistocene age. In each experiment we ponded water in a 1-m-diameter infiltration ring for 2.3 hr. For several weeks we monitored subsurface water content and matric pressure using surface electrical resistance imaging, dielectric-constant probes, heat-dissipation probes, and tensiometers. Analysis of these data using an inverse modeling technique gives the water retention and K properties needed for predictive modeling. Some properties show a consistent trend with soil age. Progressively more developed surface and near-surface features such as desert pavement and Av horizons are the likely cause of an observed consistent decline of infiltration capacity with soil age. Other properties, such as vertical flow retardation by layer contrasts, appear to have a more complicated soil-age dependence. The wash deposits display distinct depositional layering that has a retarding effect on vertical flow, an effect that may be less pronounced in the older Holocene soil

  20. Liquid metal thermal-hydraulics

    International Nuclear Information System (INIS)

    Kottowski-Duemenil, H.M.

    1994-01-01

    This textbook is a report of the 26 years activity of the Liquid Metal Boiling Working Group (LMBWG). It summarizes the state of the art of liquid metal thermo-hydraulics achieved through the collaboration of scientists concerned with the development of the Fast Breeder Reactor. The first chapter entitled ''Liquid Metal Boiling Behaviour'', presents the background and boiling mechanisms. This section gives the reader a brief but thorough survey on the superheat phenomena in liquid metals. The second chapter of the text, ''A Review of Single and Two-Phase Flow Pressure Drop Studies and Application to Flow Stability Analysis of Boiling Liquid Metal Systems'' summarizes the difficulty of pressure drop simulation of boiling sodium in core bundles. The third chapter ''Liquid Metal Dry-Out Data for Flow in Tubes and Bundles'' describes the conditions of critical heat flux which limits the coolability of the reactor core. The fourth chapter dealing with the LMFBR specific topic of ''Natural Convection Cooling of Liquid Metal Systems''. This chapter gives a review of both plant experiments and out-of-pile experiments and shows the advances in the development of computing power over the past decade of mathematical modelling ''Subassembly Blockages Suties'' are discussed in chapter five. Chapter six is entitled ''A Review of the Methods and Codes Available for the Calculation on Thermal-Hydraulics in Rod-Cluster and other Geometries, Steady state and Transient Boiling Flow Regimes, and the Validation achieves''. Codes available for the calculation of thermal-hydraulics in rod-clusters and other geometries are reviewed. Chapter seven, ''Comparative Studies of Thermohydraulic Computer Code Simulations of Sodium Boiling under Loss of Flow Conditions'', represents one of the key activities of the LMBWG. Several benchmark exercises were performed with the aim of transient sodium boiling simulation in single channels and bundle blockages under steady state conditions and loss of

  1. [Hydraulic limitation on photosynthetic rate of old Populus simonii trees in sandy soil of north Shaanxi Province].

    Science.gov (United States)

    Zuo, Li-Xiang; Li, Yang-Yang; Chen, Jia-Cun

    2014-06-01

    'Old and dwarf trees' on the loess plateau region mainly occurred among mature trees rather than among small trees. To elucidate the mechanism of tree age on 'old and dwarf trees' formation, taking Populus simonii, a tree species that accounted for the largest portion of 'old and dwarf trees' on the loess plateau, as an example, the growth, photosynthesis and hydraulic traits of P. simonii trees with different ages (young: 13-15 years, mid-aged: 31-34 years, and old: 49-54 years) were measured. The results showed that the dieback length increased, and net photosynthetic rate, stomatal conductance, transpiration rate, and whole plant hydraulic conductance decreased significantly with the increasing tree age. Both net photosynthetic rate and stomatal conductance measured at different dates were significantly and positively related to the whole plant hydraulic conductance, suggesting that the decreasing photosynthetic rate of old trees was possibly caused by the declined hydraulic conductance. Although the resistance to cavitation in stems and leaves was stronger in old trees than in young and mid-aged trees, there were no differences in midday native stem embolization degree and leaf hydraulic conductance based on the vulnerability curve estimation, suggesting that the increased hydraulic resistance of the soil-root system is probably the most important reason for decreasing the whole plant hydraulic conductance of old trees.

  2. Design of Pumps for Water Hydraulic Systems

    DEFF Research Database (Denmark)

    Klit, Peder; Olsen, Stefan; Bech, Thomas Nørgaard

    1999-01-01

    This paper considers the development of two pumps for water hydraulic applications. The pumps are based on two different working principles: The Vane-type pump and the Gear-type pump. Emphasis is put on the considerations that should be made to account for water as the hydraulic fluid.......KEYWORDS: water, pump, design, vane, gear....

  3. Uncertainty in hydraulic tests in fractured rock

    International Nuclear Information System (INIS)

    Ji, Sung-Hoon; Koh, Yong-Kwon

    2014-01-01

    Interpretation of hydraulic tests in fractured rock has uncertainty because of the different hydraulic properties of a fractured rock to a porous medium. In this study, we reviewed several interesting phenomena which show uncertainty in a hydraulic test at a fractured rock and discussed their origins and the how they should be considered during site characterisation. Our results show that the estimated hydraulic parameters of a fractured rock from a hydraulic test are associated with uncertainty due to the changed aperture and non-linear groundwater flow during the test. Although the magnitude of these two uncertainties is site-dependent, the results suggest that it is recommended to conduct a hydraulic test with a little disturbance from the natural groundwater flow to consider their uncertainty. Other effects reported from laboratory and numerical experiments such as the trapping zone effect (Boutt, 2006) and the slip condition effect (Lee, 2014) can also introduce uncertainty to a hydraulic test, which should be evaluated in a field test. It is necessary to consider the way how to evaluate the uncertainty in the hydraulic property during the site characterisation and how to apply it to the safety assessment of a subsurface repository. (authors)

  4. Hydraulically powered dissimilar teleoperated system controller design

    International Nuclear Information System (INIS)

    Jansen, J.F.; Kress, R.L.

    1996-01-01

    This paper will address two issues associated with the implementation of a hydraulically powered dissimilar master-slave teleoperated system. These issues are the overall system control architecture and the design of robust hydraulic servo controllers for the position control problem. Finally, a discussion of overall system performance on an actual teleoperated system will be presented

  5. Characteristics of Air Entrainment in Hydraulic Jump

    Science.gov (United States)

    Albarkani, M. S. S.; Tan, L. W.; Al-Gheethi, A.

    2018-04-01

    The characteristics of hydraulic jump, especially the air entrainment within jump is still not properly understood. Therefore, the current work aimed to determine the size and number of air entrainment formed in hydraulic jump at three different Froude numbers and to obtain the relationship between Froude number with the size and number of air entrainment in hydraulic jump. Experiments of hydraulic jump were conducted in a 10 m long and 0.3 m wide Armfield S6MKII glass-sided tilting flume. Hydraulic jumps were produced by flow under sluice gate with varying Froude number. The air entrainment of the hydraulic jump was captured with a Canon Power Shot SX40 HS digital camera in video format at 24 frames per second. Three discharges have been considered, i.e. 0.010 m3/s, 0.011 m3/s, and 0.013 m3/s. For hydraulic jump formed in each discharge, 32 frames were selected for the purpose of analysing the size and number of air entrainment in hydraulic jump. The results revealed that that there is a tendency to have greater range in sizes of air bubbles as Fr1 increases. Experiments with Fr1 = 7.547. 7.707, and 7.924 shown that the number of air bubbles increases exponentially with Fr1 at a relationship of N = 1.3814 e 0.9795Fr1.

  6. Hydraulic loop: practices using open control systems

    International Nuclear Information System (INIS)

    Carrasco, J.A.; Alonso, L.; Sanchez, F.

    1998-01-01

    The Tecnatom Hydraulic Loop is a dynamic training platform. It has been designed with the purpose of improving the work in teams. With this system, the student can obtain a full scope vision of a system. The hydraulic Loop is a part of the Tecnatom Maintenance Centre. The first objective of the hydraulic Loop is the instruction in components, process and process control using open control system. All the personal of an electric power plant can be trained in the Hydraulic Loop with specific courses. The development of a dynamic tool for tests previous to plant installations has been an additional objective of the Hydraulic Loop. The use of this platform is complementary to the use of full-scope simulators in order to debug and to analyse advanced control strategies. (Author)

  7. Hydraulic jumps in a channel

    DEFF Research Database (Denmark)

    Bonn, D.; Andersen, Anders Peter; Bohr, Tomas

    2009-01-01

    We present a study of hydraulic jumps with flow predominantly in one direction, created either by confining the flow to a narrow channel with parallel walls or by providing an inflow in the form of a narrow sheet. In the channel flow, we find a linear height profile upstream of the jump as expected......'s mixing-length theory with a mixing length that is proportional to the height of the fluid layer. Using averaged boundary-layer equations, taking into account the friction with the channel walls and the eddy viscosity, the flow both upstream and downstream of the jump can be understood. For the downstream...... subcritical flow, we assume that the critical height is attained close to the channel outlet. We use mass and momentum conservation to determine the position of the jump and obtain an estimate which is in rough agreement with our experiment. We show that the averaging method with a varying velocity profile...

  8. HANARO thermal hydraulic accident analysis

    Energy Technology Data Exchange (ETDEWEB)

    Park, Chul; Kim, Heon Il; Lee, Bo Yook; Lee, Sang Yong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1996-06-01

    For the safety assessment of HANARO, accident analyses for the anticipated operational transients, accident scenarios and limiting accident scenarios were conducted. To do this, the commercial nuclear reactor system code. RELAP5/MOD2 was modified to RELAP5/KMRR; the thermal hydraulic correlations and the heat exchanger model was changed to incorporate HANARO characteristics. This report summarizes the RELAP/KMRR calculation results and the subchannel analyses results based on the RELAP/KMRR results. During the calculation, major concern was placed on the integrity of the fuel. For all the scenarios, the important accident analysis parameters, i.e., fuel centerline temperatures and the minimum critical heat flux ratio(MCHFR), satisfied safe design limits. It was verified, therefore, that the HANARO was safely designed. 21 tabs., 89 figs., 39 refs. (Author) .new.

  9. Hydraulically amplified PZT mems actuator

    Science.gov (United States)

    Miles, Robin R.

    2004-11-02

    A hydraulically amplified microelectromechanical systems actuator. A piece of piezoelectric material or stacked piezo bimorph is bonded or deposited as a thin film. The piece is operatively connected to a primary membrane. A reservoir is operatively connected to the primary membrane. The reservoir contains a fluid. A membrane is operatively connected to the reservoir. In operation, energizing the piezoelectric material causing the piezoelectric material to bow. Bowing of the piezoelectric material causes movement of the primary membrane. Movement of the primary membrane results in a force in being transmitted to the liquid in the reservoir. The force in the liquid causes movement of the membrane. Movement of the membrane results in an operating actuator.

  10. Dolomitic lime containing hydraulic additive

    International Nuclear Information System (INIS)

    Lagzdina, S.; Sedmalis, U.; Bidermanis, L.; Liepins, J.; Grosvalds, I.

    1997-01-01

    To obtain qualitative dolomitic lime the optimum calcination temperature of dolomite containing about 9 % of clayey substances is 900 deg C. The mechanical strength of dolomitic lime containing 30 % of brick waste additive after 6-9 months of hardening is 1.4-1.5 times higher than that of samples without hydraulic additive, for calcium lime - 2.2-2.6 times higher. Generally the mechanical strength of dolomitic lime is higher than that one of calcium lime. It can be explained by the active role of MgO in the hydration and hardening processes of dolomitic lime. Xray diffraction phase analysis was performed by X-ray diffractometer DPON-3M with Cu-K α emission filter

  11. Different hydraulic traits of woody plants from tropical forests with contrasting soil water availability.

    Science.gov (United States)

    Zhu, Shi-Dan; Chen, Ya-Jun; Fu, Pei-Li; Cao, Kun-Fang

    2017-11-01

    In southwestern China, tropical karst forests (KF) and non-karst rain forests (NKF) have different species composition and forest structure owing to contrasting soil water availability, but with a few species that occur in both forests. Plant hydraulic traits are important for understanding the species' distribution patterns in these two forest types, but related studies are rare. In this study, we investigated hydraulic conductivity, vulnerability to drought-induced cavitation and wood anatomy of 23 abundant and typical woody species from a KF and a neighboring NKF, as well as two Bauhinia liana species common to both forests. We found that the KF species tended to have higher sapwood density, smaller vessel diameter, lower specific hydraulic conductivity (ks) and leaf to sapwood area ratio, and were more resistant to cavitation than NKF species. Across the 23 species distinctly occurring in either KF or NKF, there was a significant tradeoff between hydraulic efficiency and safety, which might be an underlying mechanism for distributions of these species across the two forests. Interestingly, by possessing rather large and long vessels, the two Bauhinia liana species had extremely high ks but were also high resistance to cavitation (escaping hydraulic tradeoff). This might be partially due to their distinctly dimorphic vessels, but contribute to their wide occurrence in both forests. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  12. effective hydraulic conductivity for a soil of variable pore size

    African Journals Online (AJOL)

    eobe

    Keywords: hydraulic conductivity, soil, infiltration, permeability, water. 1. INTRODUCTION. INTRODUCTION. INTRODUCTION. Accurate determination of hydraulic conductivity is very crucial for infiltration and runoff estimation. Factors which affect water infiltration in the soil include hydraulic conductivity, wetting front and soil.

  13. Effective hydraulic resistance of actuator nozzle generating a periodic jet

    Czech Academy of Sciences Publication Activity Database

    Tesař, Václav

    2012-01-01

    Roč. 179, JUN 2012 (2012), s. 211-222 ISSN 0924-4247 R&D Projects: GA ČR(CZ) GCP101/11/J019; GA TA ČR(CZ) TA02020795 Institutional research plan: CEZ:AV0Z20760514 Keywords : nozzle * periodic flow * compressibility Subject RIV: BK - Fluid Dynamics Impact factor: 1.841, year: 2012 http://www.sciencedirect.com/science/article/pii/S0924424712001781

  14. Predicting the impact of feed spacer modification on biofouling by hydraulic characterization and biofouling studies in membrane fouling simulators

    KAUST Repository

    Siddiqui, Amber

    2016-12-22

    Feed spacers are an essential part of spiral-wound reverse osmosis (RO) and nanofiltration (NF) membrane modules. Geometric modification of feed spacers is a potential option to reduce the impact of biofouling on the performance of membrane systems. The objective of this study was to evaluate the biofouling potential of two commercially available reference feed spacers and four modified feed spacers. The spacers were compared on hydraulic characterization and in biofouling studies with membrane fouling simulators (MFSs). The virgin feed spacer was characterized hydraulically by their resistance, measured in terms of feed channel pressure drop, performed by operating MFSs at varying feed water flow rates. Short-term (9 days) biofouling studies were carried out with nutrient dosage to the MFS feed water to accelerate the biofouling rate. Long-term (96 days) biofouling studies were done without nutrient dosage to the MFS feed water. Feed channel pressure drop was monitored and accumulation of active biomass was quantified by adenosine tri phosphate (ATP) determination. The six feed spacers were ranked on pressure drop (hydraulic characterization) and on biofouling impact (biofouling studies). Significantly different trends in hydraulic resistance and biofouling impact for the six feed spacers were observed. The same ranking for biofouling impact on the feed spacers was found for the (i) short-term biofouling study with nutrient dosage and the (ii) long-term biofouling study without nutrient dosage. The ranking for hydraulic resistance for six virgin feed spacers differed significantly from the ranking of the biofouling impact, indicating that hydraulic resistance of clean feed spacers does not predict the hydraulic resistance of biofouled feed spacers. Better geometric design of feed spacers can be a suitable approach to minimize impact of biofouling in spiral wound membrane systems.

  15. Development of thermal hydraulic analysis code for IHX of FBR

    International Nuclear Information System (INIS)

    Kumagai, Hiromichi; Naohara, Nobuyuki

    1991-01-01

    In order to obtain flow resistance correlations for thermal-hydrauric analysis code concerned with an intermediate heat exchanger (IHX) of FBR, the hydraulic experiment by air was carried out through a bundle of tubes arranged in an in-line and staggard fashion. The main results are summarized as follows. (1) On pressure loss per unit length of a tube bundle, which is densely a regular triangle arrangement, the in-line fashion is almost the same as the staggard one. (2) In case of 30deg sector model for IHX tube bundle, pressure loss is 1/3 in comparison with the in-line or staggard arrangement. (3) By this experimental data, flow resistance correlations for thermalhydrauric analysis code are obtained. (author)

  16. Stochastic joint inversion of hydrogeophysical data for salt tracer test monitoring and hydraulic conductivity imaging

    Science.gov (United States)

    Jardani, A.; Revil, A.; Dupont, J. P.

    2013-02-01

    The assessment of hydraulic conductivity of heterogeneous aquifers is a difficult task using traditional hydrogeological methods (e.g., steady state or transient pumping tests) due to their low spatial resolution. Geophysical measurements performed at the ground surface and in boreholes provide additional information for increasing the resolution and accuracy of the inverted hydraulic conductivity field. We used a stochastic joint inversion of Direct Current (DC) resistivity and self-potential (SP) data plus in situ measurement of the salinity in a downstream well during a synthetic salt tracer experiment to reconstruct the hydraulic conductivity field between two wells. The pilot point parameterization was used to avoid over-parameterization of the inverse problem. Bounds on the model parameters were used to promote a consistent Markov chain Monte Carlo sampling of the model parameters. To evaluate the effectiveness of the joint inversion process, we compared eight cases in which the geophysical data are coupled or not to the in situ sampling of the salinity to map the hydraulic conductivity. We first tested the effectiveness of the inversion of each type of data alone (concentration sampling, self-potential, and DC resistivity), and then we combined the data two by two. We finally combined all the data together to show the value of each type of geophysical data in the joint inversion process because of their different sensitivity map. We also investigated a case in which the data were contaminated with noise and the variogram unknown and inverted stochastically. The results of the inversion revealed that incorporating the self-potential data improves the estimate of hydraulic conductivity field especially when the self-potential data were combined to the salt concentration measurement in the second well or to the time-lapse cross-well electrical resistivity data. Various tests were also performed to quantify the uncertainty in the inverted hydraulic conductivity

  17. Thermal-hydraulic unreliability of passive systems

    International Nuclear Information System (INIS)

    Tzanos, C.P.; Saltos, N.T.

    1995-01-01

    Advanced light water reactor designs like AP600 and the simplified boiling water reactor (SBWR) use passive safety systems for accident prevention and mitigation. Because these systems rely on natural forces for their operation, their unavailability due to hardware failures and human error is significantly smaller than that of active systems. However, the coolant flows predicted to be delivered by these systems can be subject to significant uncertainties, which in turn can lead to a significant uncertainty in the predicted thermal-hydraulic performance of the plant under accident conditions. Because of these uncertainties, there is a probability that an accident sequence for which a best estimate thermal-hydraulic analysis predicts no core damage (success sequence) may actually lead to core damage. For brevity, this probability will be called thermal-hydraulic unreliability. The assessment of this unreliability for all the success sequences requires very expensive computations. Moreover, the computational cost increases drastically as the required thermal-hydraulic reliability increases. The required computational effort can be greatly reduced if a bounding approach can be used that either eliminates the need to compute thermal-hydraulic unreliabilities, or it leads to the analysis of a few bounding sequences for which the required thermal-hydraulic reliability is relatively small. The objective of this paper is to present such an approach and determine the order of magnitude of the thermal-hydraulic unreliabilities that may have to be computed

  18. THE IMPACT OF WALL ROUGHNESS OF THE UNDERGROUND AIRWAYS ON THE VALUE OF HYDRAULIC FRICTION FACTOR

    Directory of Open Access Journals (Sweden)

    Vladimir Rendulić

    1991-12-01

    Full Text Available The studies of turbulent flows in round pipes resulted in many hydraulic formulas up to these days, which can also serve in projecting to calculate the resistance to the air flow in underground openings. The report discusses the way of establishing the hydraulic friction factor of untimbered underground workings when the value of equivalent roughness is obtained by measuring the ventilation parameters in a similar working of some other mine. A double reticular nomogram has been constructed for the fast determination of friction coefficient from the known roughness of an underground working (the paper is published in Croatian.

  19. Thermal-hydraulic analysis of a 600 MW supercritical CFB boiler with low mass flux

    International Nuclear Information System (INIS)

    Pan Jie; Yang Dong; Chen Gongming; Zhou Xu; Bi Qincheng

    2012-01-01

    Supercritical Circulating Fluidized Bed (CFB) boiler becomes an important development trend for coal-fired power plant and thermal-hydraulic analysis is a key factor for the design and operation of water wall. According to the boiler structure and furnace-sided heat flux, the water wall system of a 600 MW supercritical CFB boiler is treated in this paper as a flow network consisting of series-parallel loops, pressure grids and connecting tubes. A mathematical model for predicting the thermal-hydraulic characteristics in boiler heating surface is based on the mass, momentum and energy conservation equations of these components, which introduces numerous empirical correlations available for heat transfer and hydraulic resistance calculation. Mass flux distribution and pressure drop data in the water wall at 30%, 75% and 100% of the boiler maximum continuous rating (BMCR) are obtained by iteratively solving the model. Simultaneity, outlet vapor temperatures and metal temperatures in water wall tubes are estimated. The results show good heat transfer performance and low flow resistance, which implies that the water wall design of supercritical CFB boiler is applicable. - Highlights: → We proposed a model for thermal-hydraulic analysis of boiler heating surface. → The model is applied in a 600 MW supercritical CFB boiler. → We explore the pressure drop, mass flux and temperature distribution in water wall. → The operating safety of boiler is estimated. → The results show good heat transfer performance and low flow resistance.

  20. Thermal-hydraulic effects of transition to improved System 80TM fuel

    International Nuclear Information System (INIS)

    Rodack, T.; Joffre, P.F.; Kapoor, R.K.

    2004-01-01

    ABB CE's improved System 80 TM PWR fuel design includes GUARDIAN debris-resistant features and laser-welded Zircaloy grids. The GUARDIAN features include an Inconel grid with debris-filtering features located just above the Lower End Fitting, and a solid fuel rod bottom end cap that extends above the filtering features. Tests and analyses were done to establish the impact of these design improvements on fuel assembly hydraulic performance. Further analysis was done to determine the mixed core thermal-hydraulic performance as the transition is made over two fuel cycles to a full core of the improved System 80 TM fuel. Results confirm that the Thermal-Hydraulic (T-H) effects of the reduction in hydraulic resistance between the improved and resident fuel due to the laser-welded Zircaloy grids offsets the effects of the increased resistance GUARDIAN grid. Therefore, the mechanically improved System 80 TM fuel can be implemented with no net impact on Departure from Nucleate Boiling (DNB) margin in transition cores. (author)

  1. Hydraulic Fracturing and the Environment

    Science.gov (United States)

    Ayatollahy Tafti, T.; Aminzadeh, F.; Jafarpour, B.; de Barros, F.

    2013-12-01

    In this presentation, we highlight two key environmental concerns of hydraulic fracturing (HF), namely induced seismicity and groundwater contamination (GC). We examine the induced seismicity (IS) associated with different subsurface fluid injection and production (SFIP) operations and the key operational parameters of SFIP impacting it. In addition we review the key potential sources for possible water contamination. Both in the case of IS and GC we propose modeling and data analysis methods to quantify the risk factors to be used for monitoring and risk reduction. SFIP include presents a risk in hydraulic fracturing, waste water injection, enhanced oil recovery as well as geothermal energy operations. Although a recent report (NRC 2012) documents that HF is not responsible for most of the induced seismicities, we primarily focus on HF here. We look into vaious operational parameters such as volume and rate of water injection, the direction of the well versus the natural fracture network, the depth of the target and the local stress field and fault system, as well as other geological features. The latter would determine the potential for triggering tectonic related events by small induced seismicity events. We provide the building blocks for IS risk assessment and monitoring. The system we propose will involve adequate layers of complexity based on mapped seismic attributes as well as results from ANN and probabilistic predictive modeling workflows. This leads to a set of guidelines which further defines 'safe operating conditions' and 'safe operating zones' which will be a valuable reference for future SFIP operations. We also illustrate how HF can lead to groundwater aquifer contamination. The source of aquifer contamination can be the hydrocarbon gas or the chemicals used in the injected liquid in the formation. We explore possible pathways of contamination within and discuss the likelihood of contamination from each source. Many of the chemical compounds used

  2. Hydraulic fracturing of rock-fill dam

    Directory of Open Access Journals (Sweden)

    Jun-Jie WANG

    2016-02-01

    Full Text Available The condition in which hydraulic fracturing in core of earth-rock fill dam maybe induced, the mechanism by which the reason of hydraulic fracturing canbe explained, and the failure criterion by which the occurrence of hydraulicfracturing can be determined, were investigated. The condition dependson material properties such as, cracks in the core and low permeability ofcore soil, and “water wedging” action in cracks. An unsaturated core soiland fast impounding are the prerequisites for the formation of “waterwedging” action. The mechanism of hydraulic fracturing can be explainedby fracture mechanics. The crack propagation induced by water pressuremay follow any of mode I, mode II and mixed mode I-II. Based on testingresults of a core soil, a new criterion for hydraulic fracturing was suggested,from which mechanisms of hydraulic fracturing in the core of rock-fill damwere discussed. The results indicated that factors such as angle betweencrack surface and direction of principal stress, local stress state at thecrack, and fracture toughness KIC of core soil may largely affect theinduction of hydraulic fracturing and the mode of the propagation of thecrack.The condition in which hydraulic fracturing in core of earth-rock fill dam maybe induced, the mechanism by which the reason of hydraulic fracturing canbe explained, and the failure criterion by which the occurrence of hydraulicfracturing can be determined, were investigated. The condition dependson material properties such as, cracks in the core and low permeability ofcore soil, and “water wedging” action in cracks. An unsaturated core soiland fast impounding are the prerequisites for the formation of “waterwedging” action. The mechanism of hydraulic fracturing can be explainedby fracture mechanics. The crack propagation induced by water pressuremay follow any of mode I, mode II and mixed mode I-II. Based on testingresults of a core soil, a new criterion for hydraulic fracturing

  3. DESIGN AND CONSTRUCTION OF A HYDRAULIC PISTON

    OpenAIRE

    Santos De la Cruz, Eulogio; Rojas Lazo, Oswaldo; Yenque Dedios, Julio; Lavado Soto, Aurelio

    2014-01-01

    A hydraulic system project includes the design, materials selection and construction of the hydraulic piston, hydraulic circuit and the joint with the pump and its accesories. This equiment will be driven by the force of moving fluid, whose application is in the devices of machines, tools, printing, perforation, packing and others. El proyecto de un sistema hidráulico, comprende el diseño, selección de materiales y construcción del pistón hidráulico, circuito hidráulico y el ensamble con l...

  4. Experimental thermal hydraulics in support of FBR

    International Nuclear Information System (INIS)

    Padmakumar, G.; Anand Babu, C.; Kalyanasundaram, P.; Vaidyanathan, G.

    2009-01-01

    The thermal hydraulic design plays a crucial role for the safe and economical deployment of Liquid Metal Cooled Fast Breeder Reactor (LMFBR). Robust experimental programmes are required in support of LMFBR thermal hydraulics design. The philosophy of testing has been to construct small scale models to understand the physical behaviour and to build larger scale models to optimize the component design. The experiments are conducted either in sodium or using a simulant like water/air. The paper gives a brief account of the various thermal hydraulic experiments carried out in support of the design of Prototype Fast Breeder Reactor (PFBR). (author)

  5. Patterns of HIV-1 Drug Resistance After First-Line Antiretroviral Therapy (ART) Failure in 6 Sub-Saharan African Countries: Implications for Second-Line ART Strategies

    NARCIS (Netherlands)

    Hamers, Raph L.; Sigaloff, Kim C. E.; Wensing, Annemarie M.; Wallis, Carole L.; Kityo, Cissy; Siwale, Margaret; Mandaliya, Kishor; Ive, Prudence; Botes, Mariette E.; Wellington, Maureen; Osibogun, Akin; Stevens, Wendy S.; Rinke de Wit, Tobias F.; Schuurman, Rob; Siwale, M.; Njovu, C.; Labib, M.; Menke, J.; Botes, M. E.; Conradie, F.; Ive, P.; Sanne, I.; Wallis, C. L.; Letsoalo, E.; Stevens, W. S.; Hardman, M.; Wellington, M.; Luthy, R.; Mandaliya, K.; Abdallah, S.; Jao, I.; Dolan, M.; Namayanja, G.; Nakatudde, L.; Nankya, I.; Kiconco, M.; Abwola, M.; Mugyenyi, P.; Osibogun, A.; Akanmu, S.; Schuurman, R.; Wensing, A. M.; Straatsma, E.; Wit, F. W.; Dekker, J.; van Vugt, M.; Lange, J. M.

    2012-01-01

    Background. Human immunodeficiency virus type 1 (HIV-1) drug resistance may limit the benefits of antiretroviral therapy (ART). This cohort study examined patterns of drug-resistance mutations (DRMs) in individuals with virological failure on first-line ART at 13 clinical sites in 6 African

  6. Changes in protease activity and Cry3Aa toxin binding in the Colorado potato beetle: implications for insect resistance to Bacillus thuringiensis toxins

    Science.gov (United States)

    Olga Loseva; Mohamed Ibrahim; Mehmet Candas; C. Noah Koller; Leah S. Bauer; Lee A. Jr. Bulla

    2002-01-01

    Widespread commercial use of Bacillus thuringiensis Cry toxins to control pest insects has increased the likelihood for development of insect resistance to this entomopathogen. In this study, we investigated protease activity profiles and toxin-binding capacities in the midgut of a strain of Colorado potato beetle (CPB) that has developed resistance...

  7. Prevalence of Methicillin-Resistant Staphylococcus aureus and Other Staphylococcus Species in Raw Meat Samples Intended for Human Consumption in Benin City, Nigeria: Implications for Public Health.

    Science.gov (United States)

    Igbinosa, Etinosa O; Beshiru, Abeni; Akporehe, Lucy U; Oviasogie, Faith E; Igbinosa, Owen O

    2016-09-24

    The present study was designed to characterize methicillin-resistant staphylococci from raw meat. A total of 126 meat samples were obtained from open markets between February and April, 2015. Antimicrobial susceptibility testing was carried out using the disc diffusion method. Molecular profiling was conducted using 16S rRNA, mecA, nuc, and PVL gene signatures were detected by polymerase chain reaction assay. Fifty isolates of methicillin-resistant Staphylococcus spp. were detected in 26 (52%) pork, 14 (28%) beef and 10 (20%) chicken samples. The staphylococcal isolates were identified through partial 16S ribosomal ribonucleic acid (16S rRNA) nucleotide sequencing, and BLAST analysis of the gene sequence revealed 98%-100% staphylococcal similarity. All isolates from beef and chicken samples amplified the mecA gene, while 100% of the MRSA isolates amplified the PVL gene. The multidrug resistance profile (resistant to ≥1 antimicrobial agent in ≥3 classes of antimicrobial agents) of the staphylococcal isolates showed that 7 isolates were resistant to methicillin, penicillin, clindamycin, chloramphenicol, trimethoprim-sulfamethoxazole, kanamycin, amoxicillin, cloxacillin, erythromycin, vancomycin, and gentamycin. There was a significant regression effect from the multidrug-resistant profile on the number of isolates (p resistant strains within bacterial populations. The findings of the present study indicate that raw meats in the Benin metropolis were possibly contaminated with pathogenic and multi-drug resistant staphylococci strains and therefore could constitute a risk to public health communities.

  8. Parker Hybrid Hydraulic Drivetrain Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Collett, Raymond [Parker-Hannifin Corporation, Cleveland, OH (United States); Howland, James [Parker-Hannifin Corporation, Cleveland, OH (United States); Venkiteswaran, Prasad [National Energy Technology Lab. (NETL), Morgantown, WV (United States)

    2014-03-31

    This report examines the benefits of Parker Hannifin hydraulic hybrid brake energy recovery systems used in commercial applications for vocational purposes. A detailed background on the problem statement being addressed as well as the solution set specific for parcel delivery will be provided. Objectives of the demonstration performed in high start & stop applications included opportunities in fuel usage reduction, emissions reduction, vehicle productivity, and vehicle maintenance. Completed findings during the demonstration period and parallel investigations with NREL, CALSTART, along with a literature review will be provided herein on this research area. Lastly, results identified in the study by third parties validated the savings potential in fuel reduction of on average of 19% to 52% over the baseline in terms of mpg (Lammert, 2014, p11), Parker data for parcel delivery vehicles in the field parallels this at a range of 35% - 50%, emissions reduction of 17.4% lower CO2 per mile and 30.4% lower NOx per mile (Gallo, 2014, p15), with maintenance improvement in the areas of brake and starter replacement, while leaving room for further study in the area of productivity in terms of specific metrics that can be applied and studied.

  9. Cavitation instabilities in hydraulic machines

    International Nuclear Information System (INIS)

    Tsujimoto, Y

    2013-01-01

    Cavitation instabilities in hydraulic machines, hydro turbines and turbopump inducers, are reviewed focusing on the cause of instabilities. One-dimensional model of hydro turbine system shows that the overload surge is caused by the diffuser effect of the draft tube. Experiments show that this effect also causes the surge mode oscillations at part load. One dimensional model of a cavitating turbopump inducer shows that the mass flow gain factor, representing the cavity volume increase caused by the incidence angle increase is the cause of cavitation surge and rotating cavitation. Two dimensional model of a cavitating turbopump inducer shows that various modes of cavitation instabilities start to occur when the cavity length becomes about 65% of the blade spacing. This is caused by the interaction of the local flow near the cavity trailing edge with the leading edge of the next blade. It was shown by a 3D CFD that this is true also for real cases with tip cavitation. In all cases, it was shown that cavitation instabilities are caused by the fundamental characteristics of cavities that the cavity volume increases with the decrease of ambient pressure or the increase of the incidence angle

  10. Kuala Kemaman hydraulic model study

    International Nuclear Information System (INIS)

    Abdul Kadir Ishak

    2005-01-01

    There The problems facing the area of Kuala Kemaman are siltation and erosion at shoreline. The objectives of study are to assess the best alignment of the groyne alignment, to ascertain the most stable shoreline regime and to investigate structural measures to overcome the erosion. The scope of study are data collection, wave analysis, hydrodynamic simulation and sediment transport simulation. Numerical models MIKE 21 are used - MIKE 21 NSW, for wind-wave model, which describes the growth, decay and transformation of wind-generated waves and swell in nearshore areas. The study takes into account effects of refraction and shoaling due to varying depth, energy dissipation due to bottom friction and wave breaking, MIKE 21 HD - modelling system for 2D free-surface flow which to stimulate the hydraulics phenomena in estuaries, coastal areas and seas. Predicted tidal elevation and waves (radiation stresses) are considered into study while wind is not considered. MIKE 21 ST - the system that calculates the rates of non-cohesive (sand) sediment transport for both pure content and combined waves and current situation

  11. Study on Characteristics of Hydraulic Servo System for Force Control of Hydraulic Robots

    International Nuclear Information System (INIS)

    Kim, Hyo-gon; Han, Changsoo; Lee, Jong-won; Park, Sangdeok

    2015-01-01

    Because a hydraulic actuator has high power and force densities, this allows the weight of the robot's limbs to be reduced. This allows for good dynamic characteristics and high energy efficiency. Thus, hydraulic actuators are used in some exoskeleton robots and quadrupedal robots that require high torque. Force control is useful for robot compliance with a user or environment. However, force control of a hydraulic robot is difficult because a hydraulic servo system is highly nonlinear from a control perspective. In this study, a nonlinear model was used to develop a simulation program for a hydraulic servo system consisting of a servo valve, transmission lines, and a cylinder. The problems and considerations with regard to the force control performance for a hydraulic servo system were investigated. A force control method using the nonlinear model was proposed, and its effect was evaluated with the simulation program

  12. Study on Characteristics of Hydraulic Servo System for Force Control of Hydraulic Robots

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyo-gon; Han, Changsoo [Hanyang University, Seoul (Korea, Republic of); Lee, Jong-won [Korea University of Science and Technology, Seoul (Korea, Republic of); Park, Sangdeok [Korea Institute of Industrial Technology, Seoul (Korea, Republic of)

    2015-02-15

    Because a hydraulic actuator has high power and force densities, this allows the weight of the robot's limbs to be reduced. This allows for good dynamic characteristics and high energy efficiency. Thus, hydraulic actuators are used in some exoskeleton robots and quadrupedal robots that require high torque. Force control is useful for robot compliance with a user or environment. However, force control of a hydraulic robot is difficult because a hydraulic servo system is highly nonlinear from a control perspective. In this study, a nonlinear model was used to develop a simulation program for a hydraulic servo system consisting of a servo valve, transmission lines, and a cylinder. The problems and considerations with regard to the force control performance for a hydraulic servo system were investigated. A force control method using the nonlinear model was proposed, and its effect was evaluated with the simulation program.

  13. Emergence of colistin resistance in extended-spectrum beta lactamase producing Enterobacteriaceae isolated from food animals and its public health implication: A review

    Directory of Open Access Journals (Sweden)

    Asinamai Athliamai Bitrus

    2018-03-01

    Full Text Available Antimicrobial resistance as a result of emergence of extended-spectrum beta lactamase producing Enterobacteriaceae is a major health problem of human and animal that requires an intensive global attention. The production of beta lactamase enzymes remains as one of the major factors contributing to the development of resistance to beta lactams. These enzymes hydrolyze the beta lactam ring of the antibiotic and render it ineffective. Extended-spectrum beta lactamase producing bacteria have the ability to develop resistance to a number of antibiotics including the carbapenem and other third generation cephalosporins. In addition, the recent emergence and dissemination of the colistin resistance determinants mcr-1, mcr-2 and mcr-3 poses a serious threat to colistin as a drug of last resort in human medicine. In this review, we utilized words such as “colistin resistance and Escherichia coli”, “Klebsiella and colistin resistance”, “colistin resistance and Salmonella” as well as “detection of mcr-1 genes in Salmonella and E. coli”. The extended-spectrum beta lactamase producing bacteria under Enterobacteriaceae that are resistant to colistin possess the ability to be transferred resistant determinants to other susceptible cells at a higher frequency. In this paper, the role of manure from food animals and how air travel contributes to the dissemination of mcr-1 haboring bacteria, resistance determinants and other metabolites that constitute a public health problem was also reviewed. It is concluded that these pathogens have significant consequences to the control of infection and plays key roles in treatment failure with colistin. [J Adv Vet Anim Res 2018; 5(1.000: 1-11

  14. The trade-off between safety and efficiency in hydraulic architecture in 31 woody species in a karst area.

    Science.gov (United States)

    Fan, Da-Yong; Jie, Sheng-Lin; Liu, Chang-Cheng; Zhang, Xiang-Ying; Xu, Xin-Wu; Zhang, Shou-Ren; Xie, Zong-Qiang

    2011-08-01

    Karst topography is a special landscape shaped by the dissolution of one or more layers of soluble bedrock, usually carbonate rock such as limestone or dolomite. Due to subterranean drainage, overland flow, extraction of water by plants and evapotranspiration, there may be very limited surface water. The hydraulic architecture that plants use to adapt to karst topography is very interesting, but few systematic reports exist. The karst area in southwestern China is unique when compared with other karst areas at similar latitudes, because of its abundant precipitation, with rainfall concentrated in the growing season. In theory, resistance to water-stress-induced cavitation via air seeding should be accompanied by decreased pore hydraulic conductivity and stem hydraulic conductivity. However, evidence for such trade-offs across species is ambiguous. We measured the hydraulic structure and foliar stable carbon isotope ratios of 31 karst woody plants at three locations in Guizhou Province, China, to evaluate the functional coordination between resistance to cavitation and specific conductivity. We also applied phylogenetically independent contrast (PIC) analysis in situations where the inter-species correlations of functional traits may be biased on the potential similarity of closely related species. The average xylem tension measurement, at which 50% of hydraulic conductivity of the plants was lost (Ψ(50)), was only -1.27 MPa. Stem Ψ(50) was positively associated with specific conductance (K(s)) (P sapwood area:leaf area ratio) was negatively correlated with K(s) in both the traditional cross-species correlation and the corresponding PIC correlations (P < 0.01). The characteristics of hydraulic architecture measured in this study showed that karst plants in China are not highly cavitation-resistant species. This study also supports the idea that there may not be an evolutionary trade-off between resistance to cavitation and specific conductivity in woody

  15. Advanced Hydraulic Studies on Enhancing Particle Removal

    DEFF Research Database (Denmark)

    He, Cheng

    clarifier. The inlet zone of an existing rectangular storm water clarifier was redesigned to improve the fluid flow conditions and reduce the hydraulic head loss in order to remove the lamellar plates and adapt the clarifier to the needs of high-rate clarification of storm water with flocculant addition...... excessive local head losses and helped to select structural changes to reduce such losses. The analysis of the facility showed that with respect to hydraulic operation, the facility is a complex, highly non-linear hydraulic system. Within the existing constraints, a few structural changes examined......The removal of suspended solids and attached pollutants is one of the main treatment processes in wastewater treatment. This thesis presents studies on the hydraulic conditions of various particle removal facilities for possible ways to increase their treatment capacity and performance by utilizing...

  16. Lower Monumental Spillway Hydraulic Model Study

    National Research Council Canada - National Science Library

    Wilhelms, Steven

    2003-01-01

    A 1:40 Froudian Scale model was used to investigate the hydraulic performance of the Lower Monumental Dam spillway, stilling basin, and tailrace for dissolved gas reduction and stilling basin apron scour...

  17. Toxicity Assessment for EPA's Hydraulic Fracturing Study

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains data used to develop multiple manuscripts on the toxicity of chemicals associated with the hydraulic fracturing industry. These manuscripts...

  18. Hydraulic fracturing chemicals and fluids technology

    CERN Document Server

    Fink, Johannes

    2013-01-01

    When classifying fracturing fluids and their additives, it is important that production, operation, and completion engineers understand which chemical should be utilized in different well environments. A user's guide to the many chemicals and chemical additives used in hydraulic fracturing operations, Hydraulic Fracturing Chemicals and Fluids Technology provides an easy-to-use manual to create fluid formulations that will meet project-specific needs while protecting the environment and the life of the well. Fink creates a concise and comprehensive reference that enables the engineer to logically select and use the appropriate chemicals on any hydraulic fracturing job. The first book devoted entirely to hydraulic fracturing chemicals, Fink eliminates the guesswork so the engineer can select the best chemicals needed on the job while providing the best protection for the well, workers and environment. Pinpoints the specific compounds used in any given fracturing operation Provides a systematic approach to class...

  19. Pneumatic and hydraulic microactuators: a review

    International Nuclear Information System (INIS)

    De Volder, Michaël; Reynaerts, Dominiek

    2010-01-01

    The development of MEMS actuators is rapidly evolving and continuously new progress in terms of efficiency, power and force output is reported. Pneumatic and hydraulic are an interesting class of microactuators that are easily overlooked. Despite the 20 years of research, and hundreds of publications on this topic, these actuators are only popular in microfluidic systems. In other MEMS applications, pneumatic and hydraulic actuators are rare in comparison with electrostatic, thermal or piezo-electric actuators. However, several studies have shown that hydraulic and pneumatic actuators deliver among the highest force and power densities at microscale. It is believed that this asset is particularly important in modern industrial and medical microsystems, and therefore, pneumatic and hydraulic actuators could start playing an increasingly important role. This paper shows an in-depth overview of the developments in this field ranging from the classic inflatable membrane actuators to more complex piston–cylinder and drag-based microdevices. (topical review)

  20. National Laboratory of Hydraulics. 1996 progress report

    International Nuclear Information System (INIS)

    1996-01-01

    This progress report of the National Laboratory of Hydraulics (LNH) of Electricite de France (EdF) summarizes, first, the research and development studies carried out in 1996 for the development of research tools for industrial fluid mechanics and environmental hydraulics and for the development of computer tools (computer codes and softwares for fluid mechanics modeling, modeling of reactive, compressible, two-phase and turbulent flows and of complex chemical kinetics using finite elements and finite volume methods). A second parts describes the research studies performed for other services of EdF, concerning: the functioning of nuclear reactors (thermohydraulic studies of the reactor vessel and of the primary coolant circuit, gas flows following severe accidents, fluid-structure thermal coupling etc...), fossil fuel power plants, the equipment and operation of thermal power plants and hydraulic power plants, the use of electric power. A third part summarizes the river and marine hydraulic studies carried out for other companies. (J.S.)

  1. Transputer Control of Hydraulic Actuators and Robots

    DEFF Research Database (Denmark)

    Conrad, Finn

    1996-01-01

    Results from a Danish mechatronics research program entitled IMCIA - Intelligent Control and Intelligent Actuators. The objective is development of intelligent actuators for intelligent motion control. A mechatronics test facility with a transputer controlled hydraulic robot suiteable for real...

  2. Insecticide resistance profile of Anopheles gambiae from a phase II field station in Cové, southern Benin: implications for the evaluation of novel vector control products.

    Science.gov (United States)

    Ngufor, Corine; N'Guessan, Raphael; Fagbohoun, Josias; Subramaniam, Krishanthi; Odjo, Abibatou; Fongnikin, Augustin; Akogbeto, Martin; Weetman, David; Rowland, Mark

    2015-11-18

    Novel indoor residual spraying (IRS) and long-lasting insecticidal net (LLIN) products aimed at improving the control of pyrethroid-resistant malaria vectors have to be evaluated in Phase II semi-field experimental studies against highly pyrethroid-resistant mosquitoes. To better understand their performance it is necessary to fully characterize the species composition, resistance status and resistance mechanisms of the vector populations in the experimental hut sites. Bioassays were performed to assess phenotypic insecticide resistance in the malaria vector population at a newly constructed experimental hut site in Cové, a rice growing area in southern Benin, being used for WHOPES Phase II evaluation of newly developed LLIN and IRS products. The efficacy of standard WHOPES-approved pyrethroid LLIN and IRS products was also assessed in the experimental huts. Diagnostic genotyping techniques and microarray studies were performed to investigate the genetic basis of pyrethroid resistance in the Cové Anopheles gambiae population. The vector population at the Cové experimental hut site consisted of a mixture of Anopheles coluzzii and An. gambiae s.s. with the latter occurring at lower frequencies (23 %) and only in samples collected in the dry season. There was a high prevalence of resistance to pyrethroids and DDT (>90 % bioassay survival) with pyrethroid resistance intensity reaching 200-fold compared to the laboratory susceptible An. gambiae Kisumu strain. Standard WHOPES-approved pyrethroid IRS and LLIN products were ineffective in the experimental huts against this vector population (8-29 % mortality). The L1014F allele frequency was 89 %. CYP6P3, a cytochrome P450 validated as an efficient metabolizer of pyrethroids, was over-expressed. Characterizing pyrethroid resistance at Phase II field sites is crucial to the accurate interpretation of the performance of novel vector control products. The strong levels of pyrethroid resistance at the Cové experimental hut

  3. Hydraulic concrete composition and properties control system

    OpenAIRE

    PSHINKO O.M.; KRASNYUK A.V.; HROMOVA O.V.

    2015-01-01

    Purpose. Scientific work aims at the development and testing of information system to meet the challenges of concrete composition design and control (for railway structures and buildings) based on the physico-analytical method algorithm for hydraulic concrete composition calculation. Methodology. The proposed algorithm of hydraulic concrete composition calculation is based on the physicochemical mechanics and in particular on the rheology of elastic–viscous–plastic bodies. The system of canon...

  4. Multimodel Robust Control for Hydraulic Turbine

    OpenAIRE

    Osuský, Jakub; Števo, Stanislav

    2014-01-01

    The paper deals with the multimodel and robust control system design and their combination based on M-Δ structure. Controller design will be done in the frequency domain with nominal performance specified by phase margin. Hydraulic turbine model is analyzed as system with unstructured uncertainty, and robust stability condition is included in controller design. Multimodel and robust control approaches are presented in detail on hydraulic turbine model. Control design approaches are compared a...

  5. Data Analytics of Hydraulic Fracturing Data

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Jovan Yang [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Viswanathan, Hari [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hyman, Jeffery [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Middleton, Richard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-11

    These are a set of slides on the data analytics of hydraulic fracturing data. The conclusions from this research are the following: they proposed a permeability evolution as a new mechanism to explain hydraulic fracturing trends; they created a model to include this mechanism and it showed promising results; the paper from this research is ready for submission; they devised a way to identify and sort refractures in order to study their effects, and this paper is currently being written.

  6. FEEDBACK LINEARISATION APPLIED ON A HYDRAULIC

    DEFF Research Database (Denmark)

    Andersen, Torben Ole; Hansen, Michael Rygaard; Pedersen, Henrik C.

    2005-01-01

    is on developing and applying several different feedback linearisation (FL) controllers to the individual servo actuators in a hydraulically driven servo robot to evaluate and compare their possiblities and limitations. This is done based on both simulation and experimental results.......Generally most hydraulic systems are intrensically non-linear, why applying linear control techniques typically results in conservatively dimensioned controllers to obtain stable performance. Non-linear control techniques have the potential of overcoming these problems, and in this paper the focus...

  7. Thermal hydraulics and mechanics core design programs

    International Nuclear Information System (INIS)

    Heinecke, J.

    1992-10-01

    The report documents the work performed within the Research and Development Task T hermal hydraulics and mechanics core design programs , funded by the German government. It contains the development of new codes, the extension of existing codes, the qualification and verification of codes and the development of a code library. The overall goal of this work was to adapt the system of thermal hydraulics and mechanics codes to the permanently growing requirements of the status of science and technology

  8. BWR 9 X 9 Fuel Assembly Thermal-Hydraulic Tests (2): Hydraulic Vibration Test

    International Nuclear Information System (INIS)

    Yoshiaki Tsukuda; Katsuichiro Kamimura; Toshiitsu Hattori; Akira Tanabe; Noboru Saito; Masahiko Warashina; Yuji Nishino

    2002-01-01

    Nuclear Power Engineering Corporation (NUPEC) conducted thermal-hydraulic projects for verification of thermal-hydraulic design reliability for BWR high-burnup 8 x 8 and 9 x 9 fuel assemblies, entrusted by the Ministry of Economy, Trade and Industry (METI). As a part of the NUPEC thermal-hydraulic projects, hydraulic vibration tests using full-scale test assemblies simulating 9 x 9 fuel assemblies were carried out to evaluate BWR fuel integrity. The test data were applied to development of a new correlation for the estimation of fuel rod vibration amplitude. (authors)

  9. The importance of hydraulic architecture to the distribution patterns of trees in a central Amazonian forest.

    Science.gov (United States)

    Cosme, Luiza H M; Schietti, Juliana; Costa, Flávia R C; Oliveira, Rafael S

    2017-07-01

    Species distributions and assemblage composition may be the result of trait selection through environmental filters. Here, we ask whether filtering of species at the local scale could be attributed to their hydraulic architectural traits, revealing the basis of hydrological microhabitat partitioning in a Central Amazonian forest. We analyzed the hydraulic characteristics at tissue (anatomical traits, wood specific gravity (WSG)), organ (leaf area, specific leaf area (SLA), leaf area : sapwood area ratio) and whole-plant (height) levels for 28 pairs of congeneric species from 14 genera restricted to either valleys or plateaus of a terra-firme forest in Central Amazonia. On plateaus, species had higher WSG, but lower mean vessel area, mean vessel hydraulic diameter, sapwood area and SLA than in valleys; traits commonly associated with hydraulic safety. Mean vessel hydraulic diameter and mean vessel area increased with height for both habitats, but leaf area and leaf area : sapwood area ratio investments with tree height declined in valley vs plateau species. [Correction added after online publication 29 March 2017: the preceding sentence has been reworded.] Two strategies for either efficiency or safety were detected, based on vessel size or allocation to sapwood. In conclusion, contrasting hydrological conditions act as environmental filters, generating differences in species composition at the local scale. This has important implications for the prediction of species distributions under future climate change scenarios. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

  10. Comparative virulence of Pyrenophora teres f. teres from Syria and Tunisia and screening for resistance sources in barley: implications for breeding.

    Science.gov (United States)

    Bouajila, A; Zoghlami, N; Al Ahmed, M; Baum, M; Ghorbel, A; Nazari, K

    2011-11-01

    The aim of this study is to investigate the pathogenic diversity and virulence groups among Pyrenophora teres f. teres isolates, sampled from Syria and Tunisia, and to identify the most effective source of resistance in barley that could be used in breeding programmes to control net blotch in both countries. One hundred and four isolates of P. teres f. teres were collected from barley in different agroecological zones of Tunisia and Syria. Their virulence was evaluated using 14 barley genotypes as differential hosts. The UPGMA clustering identified high pathogenic variability; the isolates were clustered onto 20 pathotypes that were sheltered under three virulence groups, with high, intermediate and low disease scores. According to susceptibility/resistance frequencies and mean disease ratings, CI05401 cultivar ranked as the best differential when inoculated with the Syrian isolates. However, CI09214 cultivar was classified as the best effective source of resistance in Tunisia. All P. teres f. teres isolates were differentially pathogenic. CI09214 and CI05401 cultivars were released as the most effective sources of resistance in Syria and Tunisia. National and international barley breeding programmes that seek to develop resistance against P. teres f. teres in barley should strongly benefit from this study. This resistance cannot be achieved without the proper knowledge of the pathogen virulence spectrum and the sources of host resistance. © 2011 The Authors. Letters in Applied Microbiology © 2011 The Society for Applied Microbiology.

  11. Hydraulic Hybrid Fleet Vehicle Testing | Transportation Research | NREL

    Science.gov (United States)

    Hydraulic Hybrid Fleet Vehicle Evaluations Hydraulic Hybrid Fleet Vehicle Evaluations How Hydraulic Hybrid Vehicles Work Hydraulic hybrid systems can capture up to 70% of the kinetic energy that would -pressure reservoir to a high-pressure accumulator. When the vehicle accelerates, fluid in the high-pressure

  12. 46 CFR 112.50-3 - Hydraulic starting.

    Science.gov (United States)

    2010-10-01

    ... POWER SYSTEMS Emergency Diesel and Gas Turbine Engine Driven Generator Sets § 112.50-3 Hydraulic starting. A hydraulic starting system must meet the following: (a) The hydraulic starting system must be a... 46 Shipping 4 2010-10-01 2010-10-01 false Hydraulic starting. 112.50-3 Section 112.50-3 Shipping...

  13. A low order adaptive control scheme for hydraulic servo systems

    DEFF Research Database (Denmark)

    Andersen, Torben Ole; Pedersen, Henrik Clemmensen; Bech, Michael Møller

    2015-01-01

    This paper deals with high-performance position control of hydraulics servo systems in general. The hydraulic servo system used is a two link robotic manipulator actuated by two hydraulic servo cylinders. A non-linear model of the hydraulic system and a Newton-Euler based model of the mechanical...

  14. Strong oviposition preference for Bt over non-Bt maize in Spodoptera frugiperda and its implications for the evolution of resistance

    Science.gov (United States)

    2014-01-01

    Background Transgenic crops expressing Bt toxins have substantial benefits for growers in terms of reduced synthetic insecticide inputs, area-wide pest management and yield. This valuable technology depends upon delaying the evolution of resistance. The ‘high dose/refuge strategy’, in which a refuge of non-Bt plants is planted in close proximity to the Bt crop, is the foundation of most existing resistance management. Most theoretical analyses of the high dose/refuge strategy assume random oviposition across refugia and Bt crops. Results In this study we examined oviposition and survival of Spodoptera frugiperda across conventional and Bt maize and explored the impact of oviposition behavior on the evolution of resistance in simulation models. Over six growing seasons oviposition rates per plant were higher in Bt crops than in refugia. The Cry1F Bt maize variety retained largely undamaged leaves, and oviposition preference was correlated with the level of feeding damage in the refuge. In simulation models, damage-avoiding oviposition accelerated the evolution of resistance and either led to requirements for larger refugia or undermined resistance management altogether. Since larval densities affected oviposition preferences, pest population dynamics affected resistance evolution: larger refugia were weakly beneficial for resistance management if they increased pest population sizes and the concomitant degree of leaf damage. Conclusions Damaged host plants have reduced attractiveness to many insect pests, and crops expressing Bt toxins are generally less damaged than conventional counterparts. Resistance management strategies should take account of this behavior, as it has the potential to undermine the effectiveness of existing practice, especially in the tropics where many pests are polyvoltinous. Efforts to bring down total pest population sizes and/or increase the attractiveness of damaged conventional plants will have substantial benefits for slowing the

  15. Resistant plasmid profile analysis of multidrug resistant Escherichia ...

    African Journals Online (AJOL)

    Multiple drug resistance isolates causing UTI has seri- ous implications for the empiric therapy against patho- genic isolates and for the possible co-selection of antimicrobial resistant mediated by multi drug resistant plasmids21,22. E. coli from clinical isolates are known to harbour plasmids of different molecular sizes23.

  16. Parametric Assessment of Perchloroethylene Hydraulic Behaviour in a Two-Phase System

    International Nuclear Information System (INIS)

    Chatrenour, M.; Homaee, M.; Asadi Kapourchal, S.; Mahmoodian Shoshtari, M.

    2016-01-01

    Quantitative description of soil hydraulic properties is crucial for preventing organic contamination entering into the soil and groundwater. In order to assess the hydraulic behaviour of Perchloroethylene as a toxic chlorinated contaminant in soil, the retention curves for Perchloroethylene and water were determined. The Saturated hydraulic conductivity of both fluids examined was determined by the constant head method. The Perchloroethylene and water hydraulic conductivities obtained were 492.84 and 450.27 cm day-1, respectively. The porous medium retention parameters were obtained based on the van Genuchten, Brooks-Corey and Kosugi retention models. Further, the unsaturated hydraulic conductivity for both fluids was obtained based on the Mualem-Brooks-Corey, Mualem-van Genuchten and Mualem-Kosugi models. The accuracy performance of the models was assessed using some statistics including ME, RMSE, EF, CD and CRM. Results indicated that the van Genuchten model provided better estimations than other models when the fluid studied was Perchloroethylene. The results further indicated that the magnitudes of the pore-size distribution parameters and the bubbling pressure parameters are reduced more in a water-air system compared to a Perchloroethylene-air system. This can be attributed to the high viscosity of water and its considerable resistance against flow. This implies that more suction is needed to drain water out from a porous medium than Perchloroethylene. Consequently, a porous medium provides less retention for Perchloroethylene at a given quantity of fluid than water. Owing to lower Perchloroethylene viscosity, the saturated and unsaturated porous medium hydraulic conductivity of Perchloroethylene was greater than that of water. Since Perchloroethylene has lower retention and larger hydraulic conductivity than water, its infiltration into a porous medium would lead to its faster movement towards groundwater.

  17. Proceedings of the 1991 national conference on hydraulic engineering

    International Nuclear Information System (INIS)

    Shane, R.M.

    1991-01-01

    This book contains the proceedings of the 1991 National Conference of Hydraulic Engineering. The conference was held in conjunction with the International Symposium on Ground Water and a Software Exchange that facilitated exchange of information on recent software developments of interest to hydraulic engineers. Also included in the program were three mini-symposia on the Exclusive Economic Zone, Data Acquisition, and Appropriate Technology. Topics include sedimentation; appropriate technology; exclusive economic zone hydraulics; hydraulic data acquisition and display; innovative hydraulic structures and water quality applications of hydraulic research, including the hydraulics of aerating turbines; wetlands; hydraulic and hydrologic extremes; highway drainage; overtopping protection of dams; spillway design; coastal and estuarine hydraulics; scale models; computation hydraulics; GIS and expert system applications; watershed response to rainfall; probabilistic approaches; and flood control investigations

  18. Nanocoatings for High-Efficiency Industrial Hydraulic and Tooling Systems

    Energy Technology Data Exchange (ETDEWEB)

    Clifton B. Higdon III

    2011-01-07

    Industrial manufacturing in the U.S. accounts for roughly one third of the 98 quadrillion Btu total energy consumption. Motor system losses amount to 1.3 quadrillion Btu, which represents the largest proportional loss of any end-use category, while pumps alone represent over 574 trillion BTU (TBTU) of energy loss each year. The efficiency of machines with moving components is a function of the amount of energy lost to heat because of friction between contacting surfaces. The friction between these interfaces also contributes to downtime and the loss of productivity through component wear and subsequent repair. The production of new replacement parts requires additional energy. Among efforts to reduce energy losses, wear-resistant, low-friction coatings on rotating and sliding components offer a promising approach that is fully compatible with existing equipment and processes. In addition to lubrication, one of the most desirable solutions is to apply a protective coating or surface treatment to rotating or sliding components to reduce their friction coefficients, thereby leading to reduced wear. Historically, a number of materials such as diamond-like carbon (DLC), titanium nitride (TiN), titanium aluminum nitride (TiAlN), and tungsten carbide (WC) have been examined as tribological coatings. The primary objective of this project was the development of a variety of thin film nanocoatings, derived from the AlMgB14 system, with a focus on reducing wear and friction in both industrial hydraulics and cutting tool applications. Proof-of-concept studies leading up to this project had shown that the constituent phases, AlMgB14 and TiB2, were capable of producing low-friction coatings by pulsed laser deposition. These coatings combine high hardness with a low friction coefficient, and were shown to substantially reduce wear in laboratory tribology tests. Selection of the two applications was based largely on the concept of improved mechanical interface efficiencies for

  19. Research on the Robustness of the Constant Speed Control of Hydraulic Energy Storage Generation

    Directory of Open Access Journals (Sweden)

    Zengguang Liu

    2018-05-01

    Full Text Available Energy storage plays a major role in solving the fluctuation and intermittence problem of wind and the effective use of wind power. The application of the hydraulic accumulator is the most efficient and convenient way to store wind energy in hydraulic wind turbines. A hydraulic energy storage generation system (HESGS can transform hydraulic energy stored in the hydraulic accumulator into stable and constant electrical energy by controlling the variable motor, regardless of wind changes. The aim of the present study is to design a constant speed control method for the variable motor in the HESGS and investigate the influence of the controller’s main parameters on the resistance of the HESGS to external load power disturbances. Mathematical equations of all components in this system are introduced and an entire system simulation model is built. A double closed-loop control method of the variable motor is presented within this paper, which keeps the motor speed constant for the fixed frequency of electrical power generated by the HESGS. Ultimately, a series of simulations with different proportional gains and integral gains under the environment of changeless load power step are conducted. At the same time, comparison analyses of the experiment and simulation under variable load power step are performed. The results verify the correctness and the usability of the simulation model, and also indicate that the proposed control method is robust to the disturbances of changing load power.

  20. A cross-sectional study of tuberculosis drug resistance among previously treated patients in a tertiary hospital in Accra, Ghana: public health implications of standardized regimens.

    Science.gov (United States)

    Forson, Audrey; Kwara, Awewura; Kudzawu, Samuel; Omari, Michael; Otu, Jacob; Gehre, Florian; de Jong, Bouke; Antonio, Martin

    2018-04-02

    Mycobacterium tuberculosis drug resistance is a major challenge to the use of standardized regimens for tuberculosis (TB) therapy, especially among previously treated patients. We aimed to investigate the frequency and pattern of drug resistance among previously treated patients with smear-positive pulmonary tuberculosis at the Korle-Bu Teaching Hospital Chest Clinic, Accra. This was a cross-sectional survey of mycobacterial isolates from previously treated patients referred to the Chest Clinic Laboratory between October 2010 and October 2013. The Bactec MGIT 960 system for mycobactrerial culture and drug sensitivity testing (DST) was used for sputum culture of AFB smear-positive patients with relapse, treatment failure, failure of smear conversion, or default. Descriptive statistics were used to summarize patient characteristics, and frequency and patterns of drug resistance. A total of 112 isolates were studied out of 155 from previously treated patients. Twenty contaminated (12.9%) and 23 non-viable isolates (14.8%) were excluded. Of the 112 studied isolates, 53 (47.3%) were pan-sensitive to all first-line drugs tested Any resistance (mono and poly resistance) to isoniazid was found in 44 isolates (39.3%) and any resistance to streptomycin in 43 (38.4%). Thirty-one (27.7%) were MDR-TB. Eleven (35.5%) out of 31 MDR-TB isolates were pre-XDR. MDR-TB isolates were more likely than non-MDR isolates to have streptomycin and ethambutol resistance. The main findings of this study were the high prevalence of MDR-TB and streptomycin resistance among previously treated TB patients, as well as a high prevalence of pre-XDR-TB among the MDR-TB patients, which suggest that first-line and second-line DST is essential to aid the design of effective regimens for these groups of patients in Ghana.

  1. Molecular implications from ssr markers for stripe rust (puccinia striiformis F.Sp. tritici) resistance gene in bread wheat line N95175

    International Nuclear Information System (INIS)

    Ali, M.; Ji, W.G.; Hu, Y.G; Zhong, H.; Wang, C.Y.; Baloch, G.M.

    2010-01-01

    Stripe rust caused by Puccinia striiformis f. sp. tritici is one of the most devastating diseases of wheat in China as well as in Pakistan. In the present studies F2 population was established by crossing N95175 resistant to stripe rust race CYR32 with two susceptible lines Huixianhong and Abbondanza to molecularly tag resistance gene existing in wheat line N95175. The segregation of phenotype was accorded with an expected 3:1 ratio in both combinations studied and fit the model of a single dominant gene controlling stripe rust resistance in N95175. Thirty five SSR primer pairs were screened on the parents and bulks and also on individuals since resistance gene to be located in chromosome 1B. The result indicated that most of resistant plants amplified same band as resistant parent while susceptible plants amplified same as susceptible parents studied and considered that markers co-segregated with resistant loci in N95175. This yellow rust resistance gene was considered to be Yr26 originally thought to be also located in chromosome arm 1BS linked to marker loci Xgwm273 and Xgwm11 with genetic distances ranging from 1.075cM to 2.74cM in both combinations studied. However, the closest loci were observed 2.67cM for Xgwm273 and 1.075cM for Xgwm11 in Huixianhong XN95175 and Abbondanza XN95175 crosses respectively. Hence, it has been concluded that the PCR-based micro satellite markers Xgwm273 and Xgwm11 located in chromosome 1B were shown to be very effective for the detection of Yr26 gene in segregating population and can be applied in future wheat breeding strategies. (author)

  2. A mangrove creek restoration plan utilizing hydraulic modeling.

    Science.gov (United States)

    Marois, Darryl E; Mitsch, William J

    2017-11-01

    Despite the valuable ecosystem services provided by mangrove ecosystems they remain threatened around the globe. Urban development has been a primary cause for mangrove destruction and deterioration in south Florida USA for the last several decades. As a result, the restoration of mangrove forests has become an important topic of research. Using field sampling and remote-sensing we assessed the past and present hydrologic conditions of a mangrove creek and its connected mangrove forest and brackish marsh systems located on the coast of Naples Bay in southwest Florida. We concluded that the hydrology of these connected systems had been significantly altered from its natural state due to urban development. We propose here a mangrove creek restoration plan that would extend the existing creek channel 1.1 km inland through the adjacent mangrove forest and up to an adjacent brackish marsh. We then tested the hydrologic implications using a hydraulic model of the mangrove creek calibrated with tidal data from Naples Bay and water levels measured within the creek. The calibrated model was then used to simulate the resulting hydrology of our proposed restoration plan. Simulation results showed that the proposed creek extension would restore a twice-daily flooding regime to a majority of the adjacent mangrove forest and that there would still be minimal tidal influence on the brackish marsh area, keeping its salinity at an acceptable level. This study demonstrates the utility of combining field data and hydraulic modeling to aid in the design of mangrove restoration plans.

  3. Modified electrical survey for effective leakage detection at concrete hydraulic facilities

    Science.gov (United States)

    Lee, Bomi; Oh, Seokhoon

    2018-02-01

    Three original electrode arrays for the effective leakage detection of concrete hydraulic facilities through electrical resistivity surveys are proposed: 'cross-potential', 'direct-potential' and modified tomography-like arrays. The main differences with respect to the commonly used arrays are that the current line-sources are separated from potential pole lines and floated upon the water. The potential pole lines are located directly next to the facility in order to obtain intuitive data and useful interpretations of the internal conditions of the hydraulic facility. This modified configuration of the array clearly displays the horizontal variation of the electrical field around the damaged zones of the concrete hydraulic facility, and any anomalous regions that might be found between potential poles placed across the facilities. In order to facilitate the interpretation of these modified electrical surveys, a new and creative way of presenting the measurements is also proposed and an inversion approach is provided for the modified tomography-like array. A numerical modeling and two field tests were performed to verify these new arrays and interpretation methods. The cross and direct potential array implied an ability to detect small variations of the potential field near the measurement poles. The proposed array showed the overall potential distribution across the hydraulic facility which may be used to assist in the search of trouble zones within the structure, in combination with the traditional electrical resistivity array.

  4. Hydraulic Yaw System for Wind Turbines with New Compact Hydraulic Motor Principle

    DEFF Research Database (Denmark)

    Sørensen, Rasmus Mørk; Hansen, Michael Rygaard; Mouritsen, Ole Ø.

    2011-01-01

    This paper presents a new hydraulic yaw system for wind turbines. The basic component is a new type of hydraulic motor characterized by an extraordinary high specific displacement yielding high output torque in a compact form. The focus in the paper is the volumetric efficiency of the motor, which...

  5. Comparative study of methods to estimate hydraulic parameters in the hydraulically undisturbed Opalinus Clay (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Yu, C.; Matray, J.-M. [Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, (France); Yu, C.; Gonçalvès, J. [Aix Marseille Université UMR 6635 CEREGE Technopôle Environnement Arbois-Méditerranée Aix-en-Provence, Cedex 4 (France); and others

    2017-04-15

    The deep borehole (DB) experiment gave the opportunity to acquire hydraulic parameters in a hydraulically undisturbed zone of the Opalinus Clay at the Mont Terri rock laboratory (Switzerland). Three methods were used to estimate hydraulic conductivity and specific storage values of the Opalinus Clay formation and its bounding formations through the 248 m deep borehole BDB-1: application of a Poiseuille-type law involving petrophysical measurements, spectral analysis of pressure time series and in situ hydraulic tests. The hydraulic conductivity range in the Opalinus Clay given by the first method is 2 × 10{sup -14}-6 × 10{sup -13} m s{sup -1} for a cementation factor ranging between 2 and 3. These results show low vertical variability whereas in situ hydraulic tests suggest higher values up to 7 × 10{sup -12} m s{sup -1}. Core analysis provides economical estimates of the homogeneous matrix hydraulic properties but do not account for heterogeneities at larger scale such as potential tectonic conductive features. Specific storage values obtained by spectral analysis are consistent and in the order of 10{sup -6} m{sup -1}, while formulations using phase shift and gain between pore pressure signals were found to be inappropriate to evaluate hydraulic conductivity in the Opalinus Clay. The values obtained are globally in good agreement with the ones obtained previously at the rock laboratory. (authors)

  6. Electrical Resistivity Studies Between Subarnarekha And Kansabati Rivers, Paschim Medinipur (W.B.), India: Implication To Groundwater Problems In The Area.

    Science.gov (United States)

    Panda, K. P.; Jha, M. K.; Sharma, S. P.

    2017-12-01

    Various parts of the world face acute shortage of groundwater. To solve groundwater problems various approaches are followed. Interlinking of the river is one of the approaches. The southern part of the West Bengal province of India receives huge amount of rainfall (annual 1200mm). Instead of huge amount of rainfall some parts of the area are problematic for groundwater occurrence. Characterization of aquifer in this area is very important for sustainable development of water supply and artificial recharge schemes. Electrical resistivity survey was performed at regular interval from Kharagpur (north) to Subarnrekha River (south) to map the lithological variations in this area. It covers around 25 kilometers distance from Kharagpur with latitude and longitude (22°19'7.3"N 87°18'40"E) to Subarnrekha River (22°15'49.4" N 87°16'45.1" E). To locating a suitable area for artificial recharge and for the characterization of aquifers vertical electrical sounding is a robust method. Resistivity soundings were carried out with an interval of 2 to 3 kilometers. Subsurface resistivity distribution has been interpreted by using very fast simulated annealing (VFSA) global optimization technique. The study reveals that northern part of the area is problematic and does not have suitable aquifer systems. Resistivity distribution is suitable in the southern part of area and corresponds to clayey sand. Interpreted resistivity in the northern part of the area is relatively high and reveals impervious laterite layer. In southern part of the area resistivity varies between 5-10 Ohm-m at depth below 80 m. Based on the resistivity model different types of geologic units are classified and the zone of interests for aquifer has been demarcated.

  7. The successful use of transverse hydraulic fractures from horizontal wellbores

    Energy Technology Data Exchange (ETDEWEB)

    Crosby, D. G.; Yang, Z.; Rahman, S. S. [New South Wales Univ., NSW (Australia)

    1998-12-31

    Since a significant proportion of the world`s recoverable hydrocarbon resources exist in reservoirs possessing permeabilities of less than one milli-Darcy (mD), some form of permeability enhancement or stimulation is necessary if the hydrocarbons are to be exploited economically. Multi-stage, transversely fractured horizontal wellbores are shown to have the potential to greatly increase production from low permeability formations. To overcome the problems caused by near-wellbore tortuosity, common to wells with multiple fracturing from the same perforated interval, a criterion was devised which predicts the wellbore pressures to initiate secondary multiple transverse hydraulic fractures in close proximity to primary fractures. The criterion, confirmed by laboratory experiments, demonstrates that transversely fractured horizontal wellbores have limited capacities to resist the initiation of multiple fractures from adjacent perforations. This characteristic can be used in designing hydraulic fracture treatments to establish injection pressure limits or threshold pressures, above which additional multiple fractures will initiate and propagate from the wellbore. 23 refs., 1 tab., 10 figs.

  8. Power Management in Mobile Hydraulic Applications - An Approach for Designing Hydraulic Power Supply Systems

    DEFF Research Database (Denmark)

    Pedersen, Henrik Clemmensen

    2004-01-01

    Throughout the last three decades energy consumption has become one of the primary design aspects in hydraulic systems, especially for mobile hydraulic systems, as power and cooling capacity here is at limited disposal. Considering the energy usage, this is dependent on component efficiency, but ...... the hydraulic power supply in the most energy efficient way, when considering a number of load situations. Finally an example of the approach is shown to prove its validity.}......Throughout the last three decades energy consumption has become one of the primary design aspects in hydraulic systems, especially for mobile hydraulic systems, as power and cooling capacity here is at limited disposal. Considering the energy usage, this is dependent on component efficiency...

  9. Frequency of Natural Resistance within NS5a Replication Complex Domain in Hepatitis C Genotypes 1a, 1b: Possible Implication of Subtype-Specific Resistance Selection in Multiple Direct Acting Antivirals Drugs Combination Treatment

    Directory of Open Access Journals (Sweden)

    Sabrina Bagaglio

    2016-03-01

    Full Text Available Different HCV subtypes may naturally harbor different resistance selection to anti-NS5a inhibitors. 2761 sequences retrieved from the Los Alamos HCV database were analyzed in the NS5a domain 1, the target of NS5a inhibitors. The NS5a resistance-associated polymorphisms (RAPs were more frequently detected in HCV G1b compared to G1a. The prevalence of polymorphisms associated with cross-resistance to compounds in clinical use (daclatasvir, DCV, ledipasvir, LDV, ombitasvir, and OMV or scheduled to come into clinical use in the near future (IDX719, elbasvir, and ELV was higher in G1b compared to G1a (37/1552 (2.4% in 1b sequences and 15/1209 (1.2% in 1a isolates, p = 0.040. Interestingly, on the basis of the genotype-specific resistance pattern, 95 (6.1% G1b sequences had L31M RAP to DCV/IDX719, while 6 sequences of G1a (0.5% harbored L31M RAP, conferring resistance to DCV/LDV/IDX719/ELV (p < 0.0001. Finally, 28 (2.3% G1a and none of G1b isolates harbored M28V RAP to OMV (p < 0.0001. In conclusion, the pattern of subtype-specific resistance selection in the naturally occurring strains may guide the treatment option in association with direct acting antivirals (DAAs targeting different regions, particularly in patients that are difficult to cure, such as those with advanced liver disease or individuals who have failed previous DAAs.

  10. New Conceptual Model for Soil Treatment Units: Formation of Multiple Hydraulic Zones during Unsaturated Wastewater Infiltration.

    Science.gov (United States)

    Geza, Mengistu; Lowe, Kathryn S; Huntzinger, Deborah N; McCray, John E

    2013-07-01

    Onsite wastewater treatment systems are commonly used in the United States to reclaim domestic wastewater. A distinct biomat forms at the infiltrative surface, causing resistance to flow and decreasing soil moisture below the biomat. To simulate these conditions, previous modeling studies have used a two-layer approach: a thin biomat layer (1-5 cm thick) and the native soil layer below the biomat. However, the effect of wastewater application extends below the biomat layer. We used numerical modeling supported by experimental data to justify a new conceptual model that includes an intermediate zone (IZ) below the biomat. The conceptual model was set up using Hydrus 2D and calibrated against soil moisture and water flux measurements. The estimated hydraulic conductivity value for the IZ was between biomat and the native soil. The IZ has important implications for wastewater treatment. When the IZ was not considered, a loading rate of 5 cm d resulted in an 8.5-cm ponding. With the IZ, the same loading rate resulted in a 9.5-cm ponding. Without the IZ, up to 3.1 cm d of wastewater could be applied without ponding; with the IZ, only up to 2.8 cm d could be applied without ponding. The IZ also plays a significant role in soil moisture distribution. Without the IZ, near-saturation conditions were observed only within the biomat, whereas near-saturation conditions extended below the biomat with the IZ. Accurate prediction of ponding is important to prevent surfacing of wastewater. The degree of water and air saturation influences pollutant treatment efficiency through residence time, volatility, and biochemical reactions. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

  11. Emerging Gram negative resistance to last-line antimicrobial agents fosfomycin, colistin and ceftazidime-avibactam - epidemiology, laboratory detection and treatment implications.

    Science.gov (United States)

    Sherry, Norelle; Howden, Benjamin

    2018-04-01

    Multidrug-resistant (MDR) and extensively-drug-resistant (XDR) Gram-negative bacteria have emerged as a major threat to human health globally. This has resulted in the 're-discovery' of some older antimicrobials and development of new agents, however resistance has also rapidly emerged to these agents. Areas covered: Here we describe recent developments in resistance to three of the most important last-line antimicrobials for treatment of MDR and XDR Gram negatives: fosfomycin, colistin and ceftazidime-avibactam. Expert commentary: A key challenge for microbiologists and clinicians using these agents for treating patients with MDR and XDR Gram negative infections is the need to ensure appropriate reference methods are being used to test susceptibility to these agents, especially colistin and fosfomycin. These methods are not available in all laboratories meaning accurate results are either delayed, or potentially inaccurate as non-reference methods are employed. Combination therapy for MDR and XDR Gram negatives is likely to become more common, and future studies should focus on the clinical effects of monotherapy vs combination therapy, as well as validation of synergy testing methods. Effective national and international surveillance systems to detect and respond to resistance to these last line agents are also critical.

  12. The hydraulic capacity of deteriorating sewer systems.

    Science.gov (United States)

    Pollert, J; Ugarelli, R; Saegrov, S; Schilling, W; Di Federico, V

    2005-01-01

    Sewer and wastewater systems suffer from insufficient capacity, construction flaws and pipe deterioration. Consequences are structural failures, local floods, surface erosion and pollution of receiving waters bodies. European cities spend in the order of five billion Euro per year for wastewater network rehabilitation. This amount is estimated to increase due to network ageing. The project CARE-S (Computer Aided RE-habilitation of Sewer Networks) deals with sewer and storm water networks. The final project goal is to develop integrated software, which provides the most cost-efficient system of maintenance, repair and rehabilitation of sewer networks. Decisions on investments in rehabilitation often have to be made with uncertain information about the structural condition and the hydraulic performance of a sewer system. Because of this, decision-making involves considerable risks. This paper presents the results of research focused on the study of hydraulic effects caused by failures due to temporal decline of sewer systems. Hydraulic simulations are usually carried out by running commercial models that apply, as input, default values of parameters that strongly influence results. Using CCTV inspections information as dataset to catalogue principal types of failures affecting pipes, a 3D model was used to evaluate their hydraulic consequences. The translation of failures effects in parameters values producing the same hydraulic conditions caused by failures was carried out through the comparison of laboratory experiences and 3D simulations results. Those parameters could be the input of 1D commercial models instead of the default values commonly inserted.

  13. Vibration Isolation for Parallel Hydraulic Hybrid Vehicles

    Directory of Open Access Journals (Sweden)

    The M. Nguyen

    2008-01-01

    Full Text Available In recent decades, several types of hybrid vehicles have been developed in order to improve the fuel economy and to reduce the pollution. Hybrid electric vehicles (HEV have shown a significant improvement in fuel efficiency for small and medium-sized passenger vehicles and SUVs. HEV has several limitations when applied to heavy vehicles; one is that larger vehicles demand more power, which requires significantly larger battery capacities. As an alternative solution, hydraulic hybrid technology has been found effective for heavy duty vehicle because of its high power density. The mechanical batteries used in hydraulic hybrid vehicles (HHV can be charged and discharged remarkably faster than chemical batteries. This feature is essential for heavy vehicle hybridization. One of the main problems that should be solved for the successful commercialization of HHV is the excessive noise and vibration involving with the hydraulic systems. This study focuses on using magnetorheological (MR technology to reduce the noise and vibration transmissibility from the hydraulic system to the vehicle body. In order to study the noise and vibration of HHV, a hydraulic hybrid subsystem in parallel design is analyzed. This research shows that the MR elements play an important role in reducing the transmitted noise and vibration to the vehicle body. Additionally, locations and orientations of the isolation system also affect the efficiency of the noise and vibration mitigation. In simulations, a skyhook control algorithm is used to achieve the highest possible effectiveness of the MR isolation system.

  14. Implications of Farmers' Propensity to Discontinue Adoption of Downy-Mildew Resistant Maize and Improved Cowpea Varieties for Extension Education in Southwestern Nigeria

    Science.gov (United States)

    Oladele, O. I.; Adekoya, A. E.

    2006-01-01

    This paper examines the implications of farmers' propensity to discontinue the adoption of agricultural technologies in southwestern Nigeria. This is predicated on the fact that extension education process should be proactive in addressing farmers in order to sustain the adoption process. Empirical studies looking at diffusion processes from an…

  15. Low prevalence of transmitted K65R and other tenofovir resistance mutations across different HIV-1 subtypes: implications for pre-exposure prophylaxis.

    Science.gov (United States)

    Chan, Philip A; Huang, Austin; Kantor, Rami

    2012-10-15

    Tenofovir-containing regimens have demonstrated potential efficacy as pre-exposure prophylaxis (PrEP) in preventing HIV-1 infection. Transmitted drug resistance mutations associated with tenofovir, specifically the reverse transcriptase (RT) mutation K65R, may impact the effectiveness of PrEP. The worldwide prevalence of transmitted tenofovir resistance in different HIV-1 subtypes is unknown. Sequences from treatment-naïve studies and databases were aggregated and analyzed by Stanford Database tools and as per the International AIDS Society (IAS-USA) resistance criteria. RT sequences were collected from GenBank, the Stanford HIV Sequence Database and the Los Alamos HIV Sequence Database. Sequences underwent rigorous quality control measures. Tenofovir-associated resistance mutations included K65R, K70E, T69-insertion and ≥3 thymidine analogue mutations (TAMs), inclusive of M41L or L210W. A total of 19,823 sequences were evaluated across diverse HIV-1 subtypes (Subtype A: 1549 sequences, B: 9783, C: 3198, D: 483, F: 372, G: 594, H: 41, J: 69, K: 239, CRF01_AE: 1797 and CRF02_AG: 1698). Overall, tenofovir resistance prevalence was 0.4% (n=77/19,823, 95% confidence interval or CI: 0.3 to 0.5). K65R was found in 20 sequences (0.1%, 95% CI: 0.06 to 0.15). Differences in the prevalence of K65R between HIV-1 subtypes were not statistically significant. K70E and ≥3 TAMs were found in 0.015% (95% CI: 0.004 to 0.04) and 0.27% (95% CI: 0.2 to 0.4) of sequences, respectively. Prevalence of transmitted K65R and other tenofovir resistance mutations across diverse HIV-1 subtypes and recombinants is low, suggesting minimal effect on tenofovir-containing PrEP regimens.

  16. Influence of coal slurry particle composition on pipeline hydraulic transportation behavior

    Science.gov (United States)

    Li-an, Zhao; Ronghuan, Cai; Tieli, Wang

    2018-02-01

    Acting as a new type of energy transportation mode, the coal pipeline hydraulic transmission can reduce the energy transportation cost and the fly ash pollution of the conventional coal transportation. In this study, the effect of average velocity, particle size and pumping time on particle composition of coal particles during hydraulic conveying was investigated by ring tube test. Meanwhile, the effects of particle composition change on slurry viscosity, transmission resistance and critical sedimentation velocity were studied based on the experimental data. The experimental and theoretical analysis indicate that the alter of slurry particle composition can lead to the change of viscosity, resistance and critical velocity of slurry. Moreover, based on the previous studies, the critical velocity calculation model of coal slurry is proposed.

  17. A Computational Model of Hydraulic Volume Displacement Drive

    Directory of Open Access Journals (Sweden)

    V. N. Pil'gunov

    2014-01-01

    Full Text Available The paper offers a computational model of industrial-purpose hydraulic drive with two hydraulic volume adjustable working chamber machines (pump and motor. Adjustable pump equipped with the pressure control unit can be run together with several adjustable hydraulic motors on the principle of three-phase hydraulic socket-outlet with high-pressure lines, drain, and drainage system. The paper considers the pressure-controlled hydrostatic transmission with hydraulic motor as an output link. It shows a possibility to create a saving hydraulic drive using a functional tie between the adjusting parameters of the pump and hydraulic motor through the pressure difference, torque, and angular rate of the hydraulic motor shaft rotation. The programmable logic controller can implement such tie. The Coulomb and viscous frictions are taken into consideration when developing a computational model of the hydraulic volume displacement drive. Discharge balance considers external and internal leakages in equivalent clearances of hydraulic machines, as well as compression loss volume caused by hydraulic fluid compressibility and deformation of pipe walls. To correct dynamic properties of hydraulic drive, the paper offers that in discharge balance are included the additional regulated external leakages in the open circuit of hydraulic drive and regulated internal leakages in the closed-loop circuit. Generalized differential equations having functional multipliers and multilinked nature have been obtained to describe the operation of hydraulic positioning and speed drive with two hydraulic volume adjustable working chamber machines. It is shown that a proposed computational model of hydraulic drive can be taken into consideration in development of LS («Load-Sensing» drives, in which the pumping pressure is tuned to the value required for the most loaded slave motor to overcome the load. Results attained can be used both in designing the industrial-purpose heavy

  18. Effect of Subsoil Compaction on Hydraulic Parameters

    DEFF Research Database (Denmark)

    Iversen, Bo Vangsø; Berisso, Feto Esimo; Schjønning, Per

    Soil compaction is a major threat to sustainable soil quality and is increasing since agricultural machinery is becoming heavier and is used more intensively. Compaction not only reduces pore volume, but also modifies the pore connectivity. The inter-Nordic research project POSEIDON (Persistent...... effects of subsoil compaction on soil ecological services and functions) put forward the hypothesis that due to a decrease in the hydraulic conductivity in the soil matrix, compaction increases the frequency of preferential flow events in macropores and therefore increases the leaching of otherwise....... In the field the near-saturated hydraulic conductivity was measured with a tension infiltrometer in the same treatments at a depth of 30 cm. In the laboratory saturated and near-saturated hydraulic conductivity and the bulk density were measured as well. Also, macropores in the large soil cores were made...

  19. Hydraulic characterization of hydrothermally altered Nopal tuff

    Energy Technology Data Exchange (ETDEWEB)

    Green, R.T.; Meyer-James, K.A. [Southwest Research Institute, San Antonio, TX (United States); Rice, G. [George Rice and Associates, San Antonio, TX (United States)

    1995-07-01

    Understanding the mechanics of variably saturated flow in fractured-porous media is of fundamental importance to evaluating the isolation performance of the proposed high-level radioactive waste repository for the Yucca Mountain site. Developing that understanding must be founded on the analysis and interpretation of laboratory and field data. This report presents an analysis of the unsaturated hydraulic properties of tuff cores from the Pena Blanca natural analog site in Mexico. The basic intent of the analysis was to examine possible trends and relationships between the hydraulic properties and the degree of hydrothermal alteration exhibited by the tuff samples. These data were used in flow simulations to evaluate the significance of a particular conceptual (composite) model and of distinct hydraulic properties on the rate and nature of water flow.

  20. Horizontal steam generator thermal-hydraulics

    Energy Technology Data Exchange (ETDEWEB)

    Ubra, O. [SKODA Praha Company, Prague (Czechoslovakia); Doubek, M. [Czech Technical Univ., Prague (Czechoslovakia)

    1995-09-01

    Horizontal steam generators are typical components of nuclear power plants with pressure water reactor type VVER. Thermal-hydraulic behavior of horizontal steam generators is very different from the vertical U-tube steam generator, which has been extensively studied for several years. To contribute to the understanding of the horizontal steam generator thermal-hydraulics a computer program for 3-D steady state analysis of the PGV-1000 steam generator has been developed. By means of this computer program, a detailed thermal-hydraulic and thermodynamic study of the horizontal steam generator PGV-1000 has been carried out and a set of important steam generator characteristics has been obtained. The 3-D distribution of the void fraction and 3-D level profile as functions of load and secondary side pressure have been investigated and secondary side volumes and masses as functions of load and pressure have been evaluated. Some of the interesting results of calculations are presented in the paper.

  1. Design of a hydraulic ash transport system

    Energy Technology Data Exchange (ETDEWEB)

    Mirgorodskii, V.G.; Mova, M.E.; Korenev, V.E.; Grechikhin, Yu.A. (Donetskii Politekhnicheskii Institut (USSR))

    1990-04-01

    Discusses general design of a hydraulic ash removal system to be employed at the reconstructed six 225 MW blocks of the Mironov State Regional Power Plant in the USSR. The blocks burn low-grade solid fuel with an ash content of up to 40.5%. Large quantities of ash have to be moved from the plant (total ash production 60 t/h, using 570 t/h of water for cooling and moistening). An optimum hydraulic ash transportation system would include a two-section airlift pumping system, shown in a diagram. Technological advantages of using this airlift system are enumerated, including short pipes, reduction in required water quantity and the possibility of siting hydraulic pumps at zero level.

  2. Hydraulic characterization of hydrothermally altered Nopal tuff

    International Nuclear Information System (INIS)

    Green, R.T.; Meyer-James, K.A.; Rice, G.

    1995-07-01

    Understanding the mechanics of variably saturated flow in fractured-porous media is of fundamental importance to evaluating the isolation performance of the proposed high-level radioactive waste repository for the Yucca Mountain site. Developing that understanding must be founded on the analysis and interpretation of laboratory and field data. This report presents an analysis of the unsaturated hydraulic properties of tuff cores from the Pena Blanca natural analog site in Mexico. The basic intent of the analysis was to examine possible trends and relationships between the hydraulic properties and the degree of hydrothermal alteration exhibited by the tuff samples. These data were used in flow simulations to evaluate the significance of a particular conceptual (composite) model and of distinct hydraulic properties on the rate and nature of water flow

  3. Hydraulic Properties related to Stream Reaeration

    Energy Technology Data Exchange (ETDEWEB)

    Tsivoglou, E. C.; Wallace, J. R. [School of Civil Engineering, Georgia Institute of Technology, Atlanta, GA (United States)

    1970-09-15

    The paper reports the results of recent and current field tracer experiments designed to investigate the relationships between the reaeration capacity of a flowing stream and the stream's hydraulic properties. The purpose of the studies is to develop models for the accurate prediction of stream reaeration capacity on the basis of observation of the associated hydraulic properties. The ability of a flowing stream to absorb oxygen from the overlying atmosphere is the principal process by which the stream is able to recover its dissolved oxygen resources once they have been depleted by bacterial degradation of organic wastes. Accurate knowledge of stream reaeration capacity is therefore a necessity in determining the required degree of waste treatment, and the associated costs, in any specific case. Oxygen absorption can only occur at the air-water interface, hence reaeration is a direct function of the rate of surface water replacement due to turbulent mixing. The latter is not directly observable, and so reaeration capacity has not been observable before the quite recent development of a gaseous radiotracer technique for field measurement of reaeration. This procedure involves the simultaneous use of three tracers, namely a fluorescent dye for time of flow, tritiated water for accurate dispersion measurement, and dissolved krypton-85 for measurement of gas transfer. Field results obtained by this technique are highly reproducible. Field tracer studies of the reaeration capacities of three medium-sized streams have been conducted over a total of about fifty river miles. Associated hydraulic properties such as stream flow, cross-sectional area, depth, velocity, hydraulic gradient and dispersion have also been measured. Features such as waterfalls, rapids and pools are included, and more than eighty observations of the reaeration capacities of individual stream reaches have been made. The paper reports the observed relationships between stream reaeration capacity and

  4. Hydraulic properties related to stream reaeration

    Energy Technology Data Exchange (ETDEWEB)

    Tsivoglou, E C; Wallace, J R [School of Civil Engineering, Georgia Institute of Technology, Atlanta, GA (United States)

    1970-09-15

    The paper reports the results of recent and current field tracer experiments designed to investigate the relationships between the reaeration capacity of a flowing stream and the stream's hydraulic properties. The purpose of the studies is to develop models for the accurate prediction of stream reaeration capacity on the basis of observation of the associated hydraulic properties. The ability of a flowing stream to absorb oxygen from the overlying atmosphere is the principal process by which the stream is able to recover its dissolved oxygen resources once they have been depleted by bacterial degradation of organic wastes. Accurate knowledge of stream reaeration capacity is therefore a necessity in determining the required degree of waste treatment, and the associated costs, in any specific case. Oxygen absorption can only occur at the air-water interface, hence reaeration is a direct function of the rate of surface water replacement due to turbulent mixing. The latter is not directly observable, and so reaeration capacity has not been observable before the quite recent development of a gaseous radiotracer technique for field measurement of reaeration. This procedure involves the simultaneous use of three tracers, namely a fluorescent dye for time of flow, tritiated water for accurate dispersion measurement, and dissolved krypton-85 for measurement of gas transfer. Field results obtained by this technique are highly reproducible. Field tracer studies of the reaeration capacities of three medium-sized streams have been conducted over a total of about fifty river miles. Associated hydraulic properties such as stream flow, cross-sectional area, depth, velocity, hydraulic gradient and dispersion have also been measured. Features such as waterfalls, rapids and pools are included, and more than eighty observations of the reaeration capacities of individual stream reaches have been made. The paper reports the observed relationships between stream reaeration capacity and

  5. Co-detection of Panton-Valentine leukocidin encoding genes and cotrimoxazole resistance in Staphylococcus aureus in Gabon: implications for HIV-patients' care

    NARCIS (Netherlands)

    Kraef, Christian; Alabi, Abraham S.; Peters, Georg; Becker, Karsten; Kremsner, Peter G.; Rossatanga, Elie G.; Mellmann, Alexander; Grobusch, Martin P.; Zanger, Philipp; Schaumburg, Frieder

    2015-01-01

    Patients infected with the human immuno deficiency virus (HIV) are frequently exposed to antimicrobial agents. This might have an impact on the resistance profile, genetic background and virulence factors of colonizing Staphylococcus aureus. Sub-Saharan Africa is considered to be endemic for

  6. Promoting water hydraulics in Malaysia: A green educational approach

    Science.gov (United States)

    Yusof, Ahmad Anas; Zaili, Zarin Syukri; Hassan, Siti Nor Habibah; Tuan, Tee Boon; Saadun, Mohd Noor Asril; Ibrahim, Mohd Qadafie

    2014-10-01

    In promoting water hydraulics in Malaysia, this paper presents research development of water hydraulics educational training system for secondary and tertiary levels in Malaysia. Water hydraulics trainer with robotic attachment has been studied in order to promote the usefulness of such educational tools in promoting sustainability and green technology in the country. The trainer is being developed in order to allow constructive curriculum development and continuous marketing research for the effectiveness and usefulness of using water in hydraulic power trainer. The research on water-based hydraulic trainer is now possible with the current development in water hydraulics technology.

  7. Assessment of antibiotic resistance genes and integrons in commensal Escherichia coli from the Indian urban waste water: Implications and significance for public health

    Directory of Open Access Journals (Sweden)

    Nambram Somendro Singh

    2017-10-01

    Full Text Available Antibiotics like β-lactams, quinolones/fluoroquinolones, aminoglycosides and tetracycline constitute the major mainstay of treatment against most infectious diseases including Escherichia coli. Indiscriminate use of antibiotics for human and animal well-being has generated an enormous evolutionary pressure on bacteria especially E.coli, which has a highly plastic/evolving genome. Though, antibiotic resistance (AR has been extensively studied in pathogenic E.coli, commensal strains have been studied less owing to lesser clinical significance. However, commensal strains pose a serious threat as reservoirs and transmitters of resistance genes to other bacteria. Therefore, the present study was undertaken to investigate the prevalence of resistance genes and integrons in commensal E.coli isolated from river Yamuna, Delhi, India, which receives plentiful urban waste water. Eighty three well-characterized E.coli strains of phylogroups A and B1 isolated from river Yamuna were investigated. Antimicrobial susceptibilities and minimal inhibitory concentrations (MICs for β-lactams, aminoglycosides, tetracycline and quinolone/fluoroquinolone were determined by disk diffusion and Etest, according to Clinical and Laboratory Standards Institute (CLSI guidelines. Production of Extended spectrum β-lactamases (ESBL and AmpC was investigated. Prevalence of antibiotic-resistance genes for β-lactams (blaTEM,blaSHV, blaCTX-M, blaOXA, blaCMY-42, aminoglycosides (rmtA, rmtB, rmtC, armA, str, aacC2, tetracycline (tetA, tetR, tetM, tetW, and plasmid-mediated quinolone resistance, PMQR (qnrA, qnrB, qnrC, qnrD, qnrS, qep, aac were assessed. Integrons and  gene-cassette arrays were characterized. Commensal E.coli strains showed a higher resistance to ampicillin (95%, less to cefazolin (45% and still lesser to tetracycline (15%. About 19% of these strains showed multidrug resistant (three or more classes of antibiotics, of which 15% also produced ESBLs. None of the

  8. Hydraulic modelling of the CARA Fuel element

    International Nuclear Information System (INIS)

    Brasnarof, Daniel O.; Juanico, Luis; Giorgi, M.; Ghiselli, Alberto M.; Zampach, Ruben; Fiori, Jose M.; Yedros, Pablo A.

    2004-01-01

    The CARA fuel element is been developing by the National Atomic Energy Commission for both Argentinean PHWRs. In order to keep the hydraulic restriction in their fuel channels, one of CARA's goals is to keep its similarity with both present fuel elements. In this paper is presented pressure drop test performed at a low-pressure facility (Reynolds numbers between 5x10 4 and 1,5x10 5 ) and rational base models for their spacer grid and rod assembly. Using these models, we could estimate the CARA hydraulic performance in reactor conditions that have shown to be satisfactory. (author) [es

  9. Plug & Play Control of Hydraulic Networks

    DEFF Research Database (Denmark)

    Jensen, Tom Nørgaard

    2012-01-01

    Process Control research program, which the work presented here is a part of. An industrial case study involving a large-scale hydraulic network with non-linear dynamics is studied. The hydraulic network underlies a district heating system, which provides heating water to a number of end-users in a city...... district. The case study considers a novel approach to the design of district heating systems in which the diameter of the pipes used in the system is reduced in order to reduce the heat losses in the system, thereby making it profitable to provide district heating to areas with low energy demands. The new...

  10. Mineral resource of the month: hydraulic cement

    Science.gov (United States)

    van Oss, Hendrik G.

    2012-01-01

    Hydraulic cements are the binders in concrete and most mortars and stuccos. Concrete, particularly the reinforced variety, is the most versatile of all construction materials, and most of the hydraulic cement produced worldwide is portland cement or similar cements that have portland cement as a basis, such as blended cements and masonry cements. Cement typically makes up less than 15 percent of the concrete mix; most of the rest is aggregates. Not counting the weight of reinforcing media, 1 ton of cement will typically yield about 8 tons of concrete.

  11. Hydraulic efficiency of a Rushton turbine impeller

    Science.gov (United States)

    Chara, Z.; Kysela, B.; Fort, I.

    2017-07-01

    Based on CFD simulations hydraulic efficiency of a standard Rushton turbine impeller in a baffled tank was determined at a Reynolds number of ReM=33330. Instantaneous values of pressure and velocity components were used to draw up the macroscopic balance of the mechanical energy. It was shown that the hydraulic efficiency of the Rushton turbine impeller (energy dissipated in a bulk volume) is about 57%. Using this result we estimated a length scale in a non-dimensional equation of kinetic energy dissipation rate in the bulk volume as L=D/2.62.

  12. The hydraulics of the pressurized water reactors

    International Nuclear Information System (INIS)

    Bouchter, J.C.; Barbier, D.; Caruso, A.

    1999-01-01

    The SFEN organized, the 10 june 1999 at Paris, a meeting in the domain of the PWR hydraulics and in particular the hydraulic phenomena concerning the vessel and the vapor generators. The papers presented showed the importance of the industrial stakes with their associated phenomena: cores performance and safety with the more homogenous cooling system, the rods and the control rods wear, the temperature control, the fluid-structure interactions. A great part was also devoted to the progresses in the domain of the numerical simulation and the models and algorithms qualification. (A.L.B.)

  13. Hydraulic regenerative system for a light vehicle

    OpenAIRE

    Orpella Aceret, Jordi; Guinart Trayter, Xavier

    2009-01-01

    The thesis is based in a constructed light vehicle that must be improved by adding a hydraulic energy recovery system. This vehicle named as TrecoLiTH, participated in the Formula Electric and Hybrid competition (Formula EHI) 2009 in Italy -Rome- and won several awards. This system consists in two hydraulic motors hub mounted which are used to store fluid at high pressure in an accumulator when braking. Through a valve the pressure will flow from the high pressure accumulator to the low press...

  14. A hydraulic device for unloading coke

    Energy Technology Data Exchange (ETDEWEB)

    Kretinin, M.V.; Abizgildin, U.M.; Kirillov, T.S.; Makarov, M.I.; Prokopov, O.I.; Solov' ev, A.M.

    1979-07-15

    A hydraulic device for unloading petroleum coke from slow carbonization chambers is characterized by an arrangement whereby in order to increase the output of large size coke by controlling the increment of the cutting line of the coke, the mechanism used to move the rod in the hydraulic cutter is built in the form of a rod rotation rotor; a gear wheel is mounted on the immobile section of this rotor, and on the mobile section a multi-stage regulator is installed. The drive gear of the regulator is engaged with the gear wheel, while the driven gear is connected to the rack, which is fastened to the rod.

  15. Australian consumer perspectives, attitudes and behaviours on antibiotic use and antibiotic resistance: a qualitative study with implications for public health policy and practice.

    Science.gov (United States)

    Lum, Elaine P M; Page, Katie; Nissen, Lisa; Doust, Jenny; Graves, Nicholas

    2017-10-10

    Consumers receive over 27 million antibiotic prescriptions annually in Australian primary healthcare. Hence, consumers are a key group to engage in the fight against antibiotic resistance. There is a paucity of research pertaining to consumers in the Australian healthcare environment. This study aimed to investigate the perspectives, attitudes and behaviours of Australian consumers on antibiotic use and antibiotic resistance, to inform national programs for reducing inappropriate antibiotic consumption. Semi-structured interviews with 32 consumers recruited via convenience and snowball sampling from a university population in South East Queensland. Interview transcripts were deductively and inductively coded. Main themes were identified using iterative thematic analysis. Three themes emerged from the analysis, to elucidate factors affecting antibiotic use: (a) prescription type; (b) consumer attitudes, behaviours, skills and knowledge; and (c) consumer engagement with antibiotic resistance. Consumers held mixed views regarding the use of delayed antibiotic prescriptions, and were often not made aware of the use of repeat antibiotic prescriptions. Consumers with regular general practitioners were more likely to have shared expectations regarding minimising the use of antibiotics. Even so, advice or information mediated by general practitioners was influential with all consumers; and helped to prevent inappropriate antibiotic use behaviours. Consumers were not aware of the free Return of Unwanted Medicines service offered by pharmacies and disposed of leftover antibiotics through household waste. To engage with mitigating antibiotic resistance, consumers required specific information. Previous public health campaigns raising awareness of antibiotics were largely not seen by this sample of consumers. Australian consumers have specific information needs regarding prescribed antibiotics to enable appropriate antibiotic use behaviours. Consumers also have expectations

  16. Australian consumer perspectives, attitudes and behaviours on antibiotic use and antibiotic resistance: a qualitative study with implications for public health policy and practice

    Directory of Open Access Journals (Sweden)

    Elaine P. M. Lum

    2017-10-01

    Full Text Available Abstract Background Consumers receive over 27 million antibiotic prescriptions annually in Australian primary healthcare. Hence, consumers are a key group to engage in the fight against antibiotic resistance. There is a paucity of research pertaining to consumers in the Australian healthcare environment. This study aimed to investigate the perspectives, attitudes and behaviours of Australian consumers on antibiotic use and antibiotic resistance, to inform national programs for reducing inappropriate antibiotic consumption. Method Semi-structured interviews with 32 consumers recruited via convenience and snowball sampling from a university population in South East Queensland. Interview transcripts were deductively and inductively coded. Main themes were identified using iterative thematic analysis. Results Three themes emerged from the analysis, to elucidate factors affecting antibiotic use: (a prescription type; (b consumer attitudes, behaviours, skills and knowledge; and (c consumer engagement with antibiotic resistance. Consumers held mixed views regarding the use of delayed antibiotic prescriptions, and were often not made aware of the use of repeat antibiotic prescriptions. Consumers with regular general practitioners were more likely to have shared expectations regarding minimising the use of antibiotics. Even so, advice or information mediated by general practitioners was influential with all consumers; and helped to prevent inappropriate antibiotic use behaviours. Consumers were not aware of the free Return of Unwanted Medicines service offered by pharmacies and disposed of leftover antibiotics through household waste. To engage with mitigating antibiotic resistance, consumers required specific information. Previous public health campaigns raising awareness of antibiotics were largely not seen by this sample of consumers. Conclusions Australian consumers have specific information needs regarding prescribed antibiotics to enable

  17. Trypanosoma brucei gambiense group 1 is distinguished by a unique amino acid substitution in the HpHb receptor implicated in human serum resistance.

    Directory of Open Access Journals (Sweden)

    Rebecca E Symula

    Full Text Available Trypanosoma brucei rhodesiense (Tbr and T. b. gambiense (Tbg, causative agents of Human African Trypanosomiasis (sleeping sickness in Africa, have evolved alternative mechanisms of resisting the activity of trypanosome lytic factors (TLFs, components of innate immunity in human serum that protect against infection by other African trypanosomes. In Tbr, lytic activity is suppressed by the Tbr-specific serum-resistance associated (SRA protein. The mechanism in Tbg is less well understood but has been hypothesized to involve altered activity and expression of haptoglobin haemoglobin receptor (HpHbR. HpHbR has been shown to facilitate internalization of TLF-1 in T.b. brucei (Tbb, a member of the T. brucei species complex that is susceptible to human serum. By evaluating the genetic variability of HpHbR in a comprehensive geographical and taxonomic context, we show that a single substitution that replaces leucine with serine at position 210 is conserved in the most widespread form of Tbg (Tbg group 1 and not found in related taxa, which are either human serum susceptible (Tbb or known to resist lysis via an alternative mechanism (Tbr and Tbg group 2. We hypothesize that this single substitution contributes to reduced uptake of TLF and thus may play a key role in conferring serum resistance to Tbg group 1. In contrast, similarity in HpHbR sequence among isolates of Tbg group 2 and Tbb/Tbr provides further evidence that human serum resistance in Tbg group 2 is likely independent of HpHbR function.

  18. Antimicrobial blue light therapy for multidrug-resistant Acinetobacter baumannii infection in a mouse burn model: implications for prophylaxis and treatment of combat-related wound infections.

    Science.gov (United States)

    Zhang, Yunsong; Zhu, Yingbo; Gupta, Asheesh; Huang, Yingying; Murray, Clinton K; Vrahas, Mark S; Sherwood, Margaret E; Baer, David G; Hamblin, Michael R; Dai, Tianhong

    2014-06-15

    In this study, we investigated the utility of antimicrobial blue light therapy for multidrug-resistant Acinetobacter baumannii infection in a mouse burn model. A bioluminescent clinical isolate of multidrug-resistant A. baumannii was obtained. The susceptibility of A. baumannii to blue light (415 nm)-inactivation was compared in vitro to that of human keratinocytes. Repeated cycles of sublethal inactivation of bacterial by blue light were performed to investigate the potential resistance development of A. baumannii to blue light. A mouse model of third degree burn infected with A. baumannii was developed. A single exposure of blue light was initiated 30 minutes after bacterial inoculation to inactivate A. baumannii in mouse burns. It was found that the multidrug-resistant A. baumannii strain was significantly more susceptible than keratinocytes to blue light inactivation. Transmission electron microscopy revealed blue light-induced ultrastructural damage in A. baumannii cells. Fluorescence spectroscopy suggested that endogenous porphyrins exist in A. baumannii cells. Blue light at an exposure of 55.8 J/cm(2) significantly reduced the bacterial burden in mouse burns. No resistance development to blue light inactivation was observed in A. baumannii after 10 cycles of sublethal inactivation of bacteria. No significant DNA damage was detected in mouse skin by means of a skin TUNEL assay after a blue light exposure of 195 J/cm(2). © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  19. Patterns of HIV-1 drug resistance after first-line antiretroviral therapy (ART) failure in 6 sub-Saharan African countries: implications for second-line ART strategies.

    Science.gov (United States)

    Hamers, Raph L; Sigaloff, Kim C E; Wensing, Annemarie M; Wallis, Carole L; Kityo, Cissy; Siwale, Margaret; Mandaliya, Kishor; Ive, Prudence; Botes, Mariette E; Wellington, Maureen; Osibogun, Akin; Stevens, Wendy S; Rinke de Wit, Tobias F; Schuurman, Rob

    2012-06-01

    Human immunodeficiency virus type 1 (HIV-1) drug resistance may limit the benefits of antiretroviral therapy (ART). This cohort study examined patterns of drug-resistance mutations (DRMs) in individuals with virological failure on first-line ART at 13 clinical sites in 6 African countries and predicted their impact on second-line drug susceptibility. A total of 2588 antiretroviral-naive individuals initiated ART consisting of different nucleoside reverse transcriptase inhibitor (NRTI) backbones (zidovudine, stavudine, tenofovir, or abacavir, plus lamivudine or emtricitabine) with either efavirenz or nevirapine. Population sequencing after 12 months of ART was retrospectively performed if HIV RNA was >1000 copies/mL. The 2010 International Antiviral Society-USA list was used to score major DRMs. The Stanford algorithm was used to predict drug susceptibility. HIV-1 sequences were generated for 142 participants who virologically failed ART, of whom 70% carried ≥1 DRM and 49% had dual-class resistance, with an average of 2.4 DRMs per sequence (range, 1-8). The most common DRMs were M184V (53.5%), K103N (28.9%), Y181C (15.5%), and G190A (14.1%). Thymidine analogue mutations were present in 8.5%. K65R was frequently selected by stavudine (15.0%) or tenofovir (27.7%). Among participants with ≥1 DRM, HIV-1 susceptibility was reduced in 93% for efavirenz/nevirapine, in 81% for lamivudine/emtricitabine, in 59% for etravirine/rilpivirine, in 27% for tenofovir, in 18% for stavudine, and in 10% for zidovudine. Early failure detection limited the accumulation of resistance. After stavudine failure in African populations, zidovudine rather than tenofovir may be preferred in second-line ART. Strategies to prevent HIV-1 resistance are a global priority.

  20. Characteristic Length Scales in Fracture Networks: Hydraulic Connectivity through Periodic Hydraulic Tests

    Science.gov (United States)

    Becker, M.; Bour, O.; Le Borgne, T.; Longuevergne, L.; Lavenant, N.; Cole, M. C.; Guiheneuf, N.

    2017-12-01

    Determining hydraulic and transport connectivity in fractured bedrock has long been an important objective in contaminant hydrogeology, petroleum engineering, and geothermal operations. A persistent obstacle to making this determination is that the characteristic length scale is nearly impossible to determine in sparsely fractured networks. Both flow and transport occur through an unknown structure of interconnected fracture and/or fracture zones making the actual length that water or solutes travel undetermined. This poses difficulties for flow and transport models. For, example, hydraulic equations require a separation distance between pumping and observation well to determine hydraulic parameters. When wells pairs are close, the structure of the network can influence the interpretation of well separation and the flow dimension of the tested system. This issue is explored using hydraulic tests conducted in a shallow fractured crystalline rock. Periodic (oscillatory) slug tests were performed at the Ploemeur fractured rock test site located in Brittany, France. Hydraulic connectivity was examined between three zones in one well and four zones in another, located 6 m apart in map view. The wells are sufficiently close, however, that the tangential distance between the tested zones ranges between 6 and 30 m. Using standard periodic formulations of radial flow, estimates of storativity scale inversely with the square of the separation distance and hydraulic diffusivity directly with the square of the separation distance. Uncertainty in the connection paths between the two wells leads to an order of magnitude uncertainty in estimates of storativity and hydraulic diffusivity, although estimates of transmissivity are unaffected. The assumed flow dimension results in alternative estimates of hydraulic parameters. In general, one is faced with the prospect of assuming the hydraulic parameter and inverting the separation distance, or vice versa. Similar uncertainties exist

  1. Hydraulic pitch control system for wind turbines: Advanced modeling and verification of an hydraulic accumulator

    DEFF Research Database (Denmark)

    Irizar, Victor; Andreasen, Casper Schousboe

    2017-01-01

    Hydraulic pitch systems provide robust and reliable control of power and speed of modern wind turbines. During emergency stops, where the pitch of the blades has to be taken to a full stop position to avoid over speed situations, hydraulic accumulators play a crucial role. Their efficiency...... and capability of providing enough energy to rotate the blades is affected by thermal processes due to the compression and decompression of the gas chamber. This paper presents an in depth study of the thermodynamical processes involved in an hydraulic accumulator during operation, and how they affect the energy...

  2. The SNARE protein SNAP23 and the SNARE-interacting protein Munc18c in human skeletal muscle are implicated in insulin resistance/type 2 diabetes

    DEFF Research Database (Denmark)

    Boström, Pontus; Andersson, Linda; Vind, Birgitte

    2010-01-01

    /cytosolic compartment in the patients with the type 2 diabetes. Expression of the SNARE-interacting protein Munc18c was higher in skeletal muscle from patients with type 2 diabetes. Studies in L6 cells showed that Munc18c promoted the expression of SNAP23. CONCLUSIONS: We have translated our previous in vitro results......OBJECTIVE: Our previous studies suggest that the SNARE protein synaptosomal-associated protein of 23 kDa (SNAP23) is involved in the link between increased lipid levels and insulin resistance in cardiomyocytes. The objective was to determine whether SNAP23 may also be involved in the known...... association between lipid accumulation in skeletal muscle and insulin resistance/type 2 diabetes in humans, as well as to identify a potential regulator of SNAP23. RESEARCH DESIGN AND METHODS: We analyzed skeletal muscle biopsies from patients with type 2 diabetes and healthy, insulin-sensitive control...

  3. Fasciola hepatica demonstrates high levels of genetic diversity, a lack of population structure and high gene flow: possible implications for drug resistance.

    Science.gov (United States)

    Beesley, Nicola J; Williams, Diana J L; Paterson, Steve; Hodgkinson, Jane

    2017-01-01

    Fasciola hepatica, the liver fluke, is a trematode parasite of considerable economic importance to the livestock industry and is a re-emerging zoonosis that poses a risk to human health in F. hepatica-endemic areas worldwide. Drug resistance is a substantial threat to the current and future control of F. hepatica, yet little is known about how the biology of the parasite influences the development and spread of resistance. Given that F. hepatica can self-fertilise and therefore inbreed, there is the potential for greater population differentiation and an increased likelihood of recessive alleles, such as drug resistance genes, coming together. This could be compounded by clonal expansion within the snail intermediate host and aggregation of parasites of the same genotype on pasture. Alternatively, widespread movement of animals that typically occurs in the UK could promote high levels of gene flow and prevent population differentiation. We identified clonal parasites with identical multilocus genotypes in 61% of hosts. Despite this, 84% of 1579 adult parasites had unique multilocus genotypes, which supports high levels of genotypic diversity within F. hepatica populations. Our analyses indicate a selfing rate no greater than 2%, suggesting that this diversity is in part due to the propensity for F. hepatica to cross-fertilise. Finally, although we identified high genetic diversity within a given host, there was little evidence for differentiation between populations from different hosts, indicating a single panmictic population. This implies that, once those emerge, anthelmintic resistance genes have the potential to spread rapidly through liver fluke populations. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  4. The invasive plant Alternanthera philoxeroides was suppressed more intensively than its native congener by a native generalist: implications for the biotic resistance hypothesis.

    Directory of Open Access Journals (Sweden)

    Shufeng Fan

    Full Text Available Prior studies on preferences of native herbivores for native or exotic plants have tested both the enemy release hypothesis and the biotic resistance hypothesis and have reported inconsistent results. The different levels of resistance of native and exotic plants to native herbivores could resolve this controversy, but little attention has been paid to this issue. In this study, we investigated population performance, photosynthesis, leaf nitrogen concentration, and the constitutive and induced resistances of the successful invasive plant, Alternanthera philoxeroides, and its native congener, Alternanthera sessilis, in the presence of three population densities of the grasshopper, Atractomorpha sinensis. When the grasshopper was absent, leaf biomass, total biomass, photosynthesis, and leaf nitrogen concentration of A. philoxeroides were higher than those of A. sessilis. However, the morphological and physiological performances of A. philoxeroides were all decreased more intensively than A. sessilis after herbivory by grasshoppers. Especially as the concentrations of constitutive lignin and cellulose in leaf of A. philoxeroides were higher than A. sessilis, A. philoxeroides exhibited increased leaf lignin concentration to reduce its palatability only at severe herbivore load, whereas, leaf lignin, cellulose, and polyphenolic concentrations of A. sessilis all increased with increasing herbivory pressure, and cellulose and polyphenolic concentrations were higher in A. sessilis than in A. philoxeroides after herbivory. Our study indicated that the capability of the invasive plant to respond to native insect damage was lower than the native plant, and the invasive plant was suppressed more intensively than its native congener by the native insect. Our results support the biotic resistance hypothesis and suggest that native herbivores can constrain the abundance and reduce the adverse effects of invasive species.

  5. Down-regulation of DNA mismatch repair proteins in human and murine tumor spheroids: implications for multicellular resistance to alkylating agents.

    Science.gov (United States)

    Francia, Giulio; Green, Shane K; Bocci, Guido; Man, Shan; Emmenegger, Urban; Ebos, John M L; Weinerman, Adina; Shaked, Yuval; Kerbel, Robert S

    2005-10-01

    Similar to other anticancer agents, intrinsic or acquired resistance to DNA-damaging chemotherapeutics is a major obstacle for cancer therapy. Current strategies aimed at overcoming this problem are mostly based on the premise that tumor cells acquire heritable genetic mutations that contribute to drug resistance. Here, we present evidence for an epigenetic, tumor cell adhesion-mediated, and reversible form of drug resistance that is associated with a reduction of DNA mismatch repair proteins PMS2 and/or MLH1 as well as other members of this DNA repair process. Growth of human breast cancer, human melanoma, and murine EMT-6 breast cancer cell lines as multicellular spheroids in vitro, which is associated with increased resistance to many chemotherapeutic drugs, including alkylating agents, is shown to lead to a reproducible down-regulation of PMS2, MLH1, or, in some cases, both as well as MHS6, MSH3, and MSH2. The observed down-regulation is in part reversible by treatment of tumor spheroids with the DNA-demethylating agent, 5-azacytidine. Thus, treatment of EMT-6 mouse mammary carcinoma spheroids with 5-azacytidine resulted in reduced and/or disrupted cell-cell adhesion, which in turn sensitized tumor spheroids to cisplatin-mediated killing in vitro. Our results suggest that antiadhesive agents might sensitize tumor spheroids to alkylating agents in part by reversing or preventing reduced DNA mismatch repair activity and that the chemosensitization properties of 5-azacytidine may conceivably reflect its role as a potential antiadhesive agent as well as reversal agent for MLH1 gene silencing in human tumors.

  6. Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer drug resistance.

    Science.gov (United States)

    Hegedüs, Csilla; Truta-Feles, Krisztina; Antalffy, Géza; Várady, György; Német, Katalin; Ozvegy-Laczka, Csilla; Kéri, György; Orfi, László; Szakács, Gergely; Settleman, Jeffrey; Váradi, András; Sarkadi, Balázs

    2012-08-01

    Human ABCG2 is a plasma membrane glycoprotein that provides physiological protection against xenobiotics. ABCG2 also significantly influences biodistribution of drugs through pharmacological tissue barriers and confers multidrug resistance to cancer cells. Moreover, ABCG2 is the molecular determinant of the side population that is characteristically enriched in normal and cancer stem cells. Numerous tumors depend on unregulated EGFR signaling, thus inhibition of this receptor by small molecular weight inhibitors such as gefitinib, and the novel second generation agents vandetanib, pelitinib and neratinib, is a promising therapeutic option. In the present study, we provide detailed biochemical characterization regarding the interaction of these EGFR inhibitors with ABCG2. We show that ABCG2 confers resistance to gefitinib and pelitinib, whereas the intracellular action of vandetanib and neratinib is unaltered by the presence of the transporter. At higher concentrations, however, all these EGFR inhibitors inhibit ABCG2 function, thereby promoting accumulation of ABCG2 substrate drugs. We also report enhanced expression of ABCG2 in gefitinib-resistant non-small cell lung cancer cells, suggesting potential clinical relevance of ABCG2 in acquired drug resistance. Since ABCG2 has important impact on both the pharmacological properties and anti-cancer efficiencies of drugs, our results regarding the novel EGFR inhibitors should provide useful information about their therapeutic applicability against ABCG2-expressing cancer cells depending on EGFR signaling. In addition, the finding that these EGFR inhibitors efficiently block ABCG2 function may help to design novel drug-combination therapeutic strategies. Copyright © 2012 Elsevier Inc. All rights reserved.

  7. mQTL-seq and classical mapping implicates the role of an AT-HOOK MOTIF CONTAINING NUCLEAR LOCALIZED (AHL) family gene in Ascochyta blight resistance of chickpea.

    Science.gov (United States)

    Kumar, Kamal; Purayannur, Savithri; Kaladhar, Vemula Chandra; Parida, Swarup Kumar; Verma, Praveen Kumar

    2018-03-01

    Ascochyta blight (AB) caused by the fungal pathogen Ascochyta rabiei is a serious foliar disease of chickpea (Cicer arietinum L.). Despite many genetic studies on chickpea-Ascochyta interaction, genome-wide scan of chickpea for the identification of AB-associated quantitative trait loci (QTLs) and their gene(s) has not been accomplished. To elucidate narrow QTLs for AB resistance, here, we report the use of multiple QTL-sequencing approach on 2 sets of extreme AB phenotype bulks derived from Cicer intraspecific and interspecific crosses. Two major QTLs, qABR4.1 and qABR4.2, and a minor QTL, qABR4.3, were identified on assembled chickpea pseudomolecule 4. We narrowed qABR4.1 to a "robust region" at 4.568-4.618 Mb through mapping on a larger intraspecific cross-derived population and comparative analysis. Among 4 genes, the CaAHL18 gene showed higher expression under Ascochyta stress in AB resistant parent suggesting that it is the candidate gene under "robust qABR4.1." Dual-luciferase assay with CaAHL18 polymorphic cis-regulatory sequences showed that allelic variation is associated with higher expression. Thus, our findings on chickpea-Ascochyta interaction have narrowed down AB resistance associated QTLs on chickpea physical map. The narrowed QTLs and gene-associated markers will help in biotechnological and breeding programs for chickpea improvement. © 2018 John Wiley & Sons Ltd.

  8. Derivation of a JC virus-resistant human glial cell line: implications for the identification of host cell factors that determine viral tropism

    International Nuclear Information System (INIS)

    Gee, Gretchen V.; Manley, Kate; Atwood, Walter J.

    2003-01-01

    JC virus (JCV) is a common human polyomavirus that infects 70-80% of the population worldwide. In immunosuppressed individuals, JCV infects oligodendrocytes and causes a fatal demyelinating disease known as progressive multifocal leukoencephalopathy (PML). The tropism of JCV is restricted to oligodendrocytes, astrocytes, and B lymphocytes. Several mechanisms may contribute to the restricted tropism of JCV, including the presence or absence of cell-type-specific transcription and replication factors and the presence or absence of cell-type-specific receptors. We have established a system to investigate cellular factors that influence viral tropism by selecting JCV-resistant cells from a susceptible glial cell line (SVG-A). SVG-A cells were subjected to several rounds of viral infection using JC virus (M1/SVEΔ). A population of resistant cells emerged (SVGR2) that were refractory to infection with the Mad-4 strain of JCV, the hybrid virus M1/SVEΔ, as well as to the related polyomavirus SV40. SVGR2 cells were as susceptible as the SVG-A cells to infection with an unrelated amphotropic retrovirus. The stage at which these cells are resistant to infection was investigated and the block appears to be at early viral gene transcription. This system should ultimately allow us to identify glial specific factors that influence the tropism of JCV

  9. Hydraulic Modular Dosaging Systems for Machine Drives

    Directory of Open Access Journals (Sweden)

    A. J. Kotlobai

    2005-01-01

    Full Text Available The justified principle of making modular dosaging systems for positive-displacement multimotor hydraulic drives used in running gear and technological equipment of mobile construction, road and agricultural machines makes it possible to synchronize motion of running parts. The examples of the realization of modular dosaging systems and an algorithm of their operation are given in the paper.

  10. Effect of Poroelasticity on Hydraulic Fracture Interactions

    DEFF Research Database (Denmark)

    Usui, Tomoya; Salimzadeh, Saeed; Paluszny, Adriana

    2017-01-01

    This study investigates, by performing finite element-based simulations, the influence of fluid leak-off and poroelasticity on growth of multiple hydraulic fractures that initiate from a single horizontal well. In this research, poroelastic deformation of the matrix is coupled with fluid flow in ...

  11. Control rod driving hydraulic pressure device

    International Nuclear Information System (INIS)

    Ishida, Kazuo.

    1990-01-01

    Discharged water after actuating control rod drives in a BWR type reactor is once discharged to a discharging header, then returned to a master control unit and, subsequently, discharged to a reactor by way of a cooling water header. The radioactive level in the discharging header and the master control unit is increased by the reactor water to increase the operator's exposure. In view of the above, a riser is disposed for connecting a hydraulic pressure control unit incorporating a directional control valve and the cooling water head. When a certain control rod is inserted, the pressurized driving water is supplied through a hydraulic pressure control unit to the control rod drives. The discharged water from the control rod drives is entered by way of the hydraulic pressure control unit into the cooling water header and then returned to the reactor by way of other hydraulic pressure control unit and the control rod drives. Thus, the reactor water is no more recycled to the master control unit to reduce the radioactive exposure. (N.H.)

  12. Elevator and hydraulics; Elevator to yuatsu

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, I. [Hitachi, Ltd., Tokyo (Japan)

    1994-07-15

    A hydraulic type elevator is installed in relatively lower buildings as compared with a rope type elevator, but the ratio in the number of installation of the former elevator is increasing. This paper explains from its construction and features to especially various control systems for the riding comfort and safety. A direct push-up system with hydraulic jacks arranged beneath a car, and an indirect push-up system that has hydraulic jacks arranged on flank of a car and transmits the movement of a plunger via a rope are available. The latter system eliminates the need of large holes to embed hydraulic jacks. While the speed is controlled by controlling flow rates of high-pressure oil, the speed, position, acceleration and even time differential calculus of the acceleration must be controlled severely. The system uses two-step control for the through-speed and the landing speed. Different systems that have been realized may include compensation for temperatures in flow rate control valves, load pressures, and oil viscosity, from learning control to fuzzy control for psychological effects, or control of inverters in motors. 13 refs., 12 figs., 1 tab.

  13. Operation of a hydraulic elevator system

    Energy Technology Data Exchange (ETDEWEB)

    Lazarev, G.A.; Li, Yu.V.; Bezuglov, N.N.

    1983-03-01

    The paper describes the hydraulic elevator system in the im. 50-letiya Oktyabr'skoi Revolutsii mine in the Karaganda basin. The system removes water and coal from the sump of a skip mine shaft. Water influx rate per day to the sump does not exceed 120 m/sup 3/, weight of coal falling from the skip is about 5,000 kg per day. The sump, 85 m deep, is closed by a screen. The elevator system consists of two pumps (one is used as a reserve pump) with a capacity of 300 m/sup 3/h. When water level exceeds the maximum permissive limit the pump is activated by an automatic control system. The coal and water mixture pumped from the sump bottom is directed to a screen which separates coal from water. Coal is fed to a coal hopper and water is pumped to a water tank. The hydraulic elevator has a capacity of 80 m/sup 3/ of mixture per hour. The slurry is tranported by a pipe of 175 mm diameter. Specifications of the pumps and pipelines are given. A scheme of the hydraulic elevator system is also shown. Economic aspects of hydraulic elevator use for removal of water and coal from deep sumps of skip shafts in the Karaganda basin also are discussed.

  14. Hydraulic brake-system for a bicycle

    NARCIS (Netherlands)

    Van Frankenhuyzen, J.

    2007-01-01

    The invention relates to a hydraulic brake system for a bicycle which may or may not be provided with an auxiliary motor, comprising a brake disc and brake claws cooperating with the brake disc, as well as fluid-containing channels (4,6) that extend between an operating organ (1) and the brake

  15. Analyses of hydraulic performance of velocity caps

    DEFF Research Database (Denmark)

    Christensen, Erik Damgaard; Degn Eskesen, Mark Chr.; Buhrkall, Jeppe

    2014-01-01

    The hydraulic performance of a velocity cap has been investigated. Velocity caps are often used in connection with offshore intakes. CFD (computational fluid dynamics) examined the flow through the cap openings and further down into the intake pipes. This was combined with dimension analyses...

  16. Hydraulic urethral dilatation after optical internal urethrotomy ...

    African Journals Online (AJOL)

    Objectives: To determine the rate of early recurrence of urethral stricture in the first six months in patients who perform hydraulic urethral dilatation(HUD) after optical internal urethrotomy (OIU) and compare the early recurrence Fate in patients who perform HUD after OIU with the recurrence rates in patients reported in the ...

  17. Separation and pattern formation in hydraulic jumps

    DEFF Research Database (Denmark)

    Bohr, Tomas; Ellegaard, C.; Hansen, A. Espe

    1998-01-01

    We present theory and experiments on the circular hydraulic jump in the stationary regime. The theory can handle the situation in which the fluid flows over an edge far away from the jump. In the experiments the external height is controlled, and a series of transitions in the flow structure appe...

  18. Towards Autonomous Control of Hydraulic Actuator Systems

    DEFF Research Database (Denmark)

    Hansen, Poul Erik; Conrad, Finn

    1998-01-01

    Presentation of new developed control algorithms to increase autonomy and intelligence of hydraulic control systems. A refinement of relaytuning method is used to determine the control parameters of a lag/lead controller and a poleplacement controller. Further, a fail-safe function is developed...

  19. Highly reliable electro-hydraulic control system

    International Nuclear Information System (INIS)

    Mande, Morima; Hiyama, Hiroshi; Takahashi, Makoto

    1984-01-01

    The unscheduled shutdown of nuclear power stations disturbs power system, and exerts large influence on power generation cost due to the lowering of capacity ratio; therefore, high reliability is required for the control system of nuclear power stations. Toshiba Corp. has exerted effort to improve the reliability of the control system of power stations, and in this report, the electro-hydraulic control system for the turbines of nuclear power stations is described. The main functions of the electro-hydraulic control system are the control of main steam pressure with steam regulation valves and turbine bypass valves, the control of turbine speed and load, the prevention of turbine overspeed, the protection of turbines and so on. The system is composed of pressure sensors and a speed sensor, the control board containing the electronic circuits for control computation and protective sequence, the oil cylinders, servo valves and opening detectors of the valves for control, a high pressure oil hydraulic machine and piping, the operating panel and so on. The main features are the adoption of tripling intermediate value selection method, the multiplying of protection sensors and the adoption of 2 out of 3 trip logic, the multiplying of power sources, the improvement of the reliability of electronic circuit hardware and oil hydraulic system. (Kako, I.)

  20. Spiral groove seal. [for hydraulic rotating shaft

    Science.gov (United States)

    Ludwig, L. P. (Inventor)

    1973-01-01

    Mating flat surfaces inhibit leakage of a fluid around a stationary shaft. A spiral groove pattern produces a pumping action toward the fluid when the shaft rotates which prevents leakage while a generated hydraulic lifting force separates the mating surfaces to minimize wear.

  1. Hydraulic and hydrochemical characteristics of the phreatic ...

    African Journals Online (AJOL)

    Hydraulic and hydrochemical characteristics of the phreatic basement aquifers in parts of southwestern Nigeria. OA Idowu, O Martins, AM Gbadebo. Abstract. No Abstract. Journal of Mining and Geology Vol. 43 (1) 2007: pp. 71-78. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD ...

  2. Energy harvesting from hydraulic pressure fluctuations

    International Nuclear Information System (INIS)

    Cunefare, K A; Skow, E A; Erturk, A; Savor, J; Verma, N; Cacan, M R

    2013-01-01

    State-of-the-art hydraulic hose and piping systems employ integral sensor nodes for structural health monitoring to avoid catastrophic failures. Energy harvesting in hydraulic systems could enable self-powered wireless sensor nodes for applications such as energy-autonomous structural health monitoring and prognosis. Hydraulic systems inherently have a high energy intensity associated with the mean pressure and flow. Accompanying the mean pressure is the dynamic pressure ripple, which is caused by the action of pumps and actuators. Pressure ripple is a deterministic source with a periodic time-domain behavior conducive to energy harvesting. An energy harvester prototype was designed for generating low-power electricity from pressure ripples. The prototype employed an axially-poled off-the-shelf piezoelectric stack. A housing isolated the stack from the hydraulic fluid while maintaining a mechanical coupling allowing for dynamic-pressure-induced deflection of the stack. The prototype exhibited an off-resonance energy harvesting problem since the fundamental resonance of the piezoelectric stack was much higher than the frequency content of the pressure ripple. The prototype was designed to provide a suitable power output for powering sensors with a maximum output of 1.2 mW. This work also presents electromechanical model simulations and experimental characterization of the piezoelectric power output from the pressure ripple in terms of the force transmitted into the harvester. (paper)

  3. Sustainable hydraulic engineering through building with nature

    NARCIS (Netherlands)

    de Vriend, Huib J.; van Koningsveld, M.; Aarninkhof, S.G.J.; de Vries, Mindert; Baptist, M.J.

    2015-01-01

    Hydraulic engineering infrastructures are of concern to many people and are likely to interfere with the environment. Moreover, they are supposed to keep on functioning for many years. In times of rapid societal and environmental change this implies that sustainability and adaptability are important

  4. Power management in hydraulically actuated mobile equipment

    DEFF Research Database (Denmark)

    Pedersen, Henrik Clemmensen; Andersen, Torben Ole; Hansen, Michael Rygaard

    2008-01-01

    The focus of the current paper is on the control of hydraulic systems when utilizing the advances that electronic control may bring with regard to power management, prioritized flow sharing and anti-stall, arising from being able to control both pump, valves and engine electronically. A simple mo...

  5. Hydraulic fracturing in anisotropic and heterogeneous rocks

    NARCIS (Netherlands)

    Valliappan, V.; Remmers, J.J.C.; Barnhoorn, A.; Smeulders, D.M.J.

    2017-01-01

    In this paper, we present a two dimensional model for modelling the hydraulic fracture process in anisotropic and heterogeneous rocks. The model is formulated using extended finite elements (XFEM) in combination with Newton-Raphson method for spatial and Euler's implicit scheme for time. The

  6. Hydraulic adjustment of Scots pine across Europe

    NARCIS (Netherlands)

    Martínez-Vilalta, J.; Cochard, H.; Mencuccini, M.; Sterck, F.J.; Herrero, A.; Korhonen, J.F.J.; Llorens, P.; Nikinmaa, E.; Nolè, A.; Poyatos, R.; Ripullone, F.; Sass-Klaassen, U.; Zweifel, R.

    2009-01-01

    The variability of branch-level hydraulic properties was assessed across 12 Scots pine populations covering a wide range of environmental conditions, including some of the southernmost populations of the species. The aims were to relate this variability to differences in climate, and to study the

  7. Massive hydraulic fracturing gas stimulation project

    International Nuclear Information System (INIS)

    Appledorn, C.R.; Mann, R.L.

    1977-01-01

    The Rio Blanco Massive Hydraulic Fracturing Project was fielded in 1974 as a joint Industry/ERDA demonstration to test the relative formations that were stimulated by the Rio Blanco Nuclear fracturing experiment. The project is a companion effort to and a continuation of the preceding nuclear stimulation project, which took place in May 1973. 8 figures

  8. Hydraulic characteristics of internal protective coatings used for rehabilitation of pipelines of water supply and sanitation systems

    Directory of Open Access Journals (Sweden)

    Orlov Vladimir

    2018-01-01

    Full Text Available The purpose of this article is to provide a comparative analysis of hydraulic characteristics of some modern organic coatings used for trenchless rehabilitation of engineering pipelines. Scotchkote 169HB pipeline inner protective coating manufactured by «3M» production company (USA and Subcote FLP coating by «Group POLYPLASTIC» Ltd (RF were the objects of this investigation. The article presents general characteristics of alternative protective coatings. A methodical approach to determination of the protective coating hydraulic characteristics is described by the tests at a special patented small-sized bench through estimation of the coatings’ hydrophoby with the terms of hydraulic characteristics. Based on the obtained results the conclusions are made concerning the feasibility of application of organic coatings compared to non-organic ones (for example, cement-sand coatings. This will enable power savings due to a lower hydraulic resistance during the water transportation. Based on the experimental studies in static and dynamic conditions on a small-sized testing bench it was proved, that the Subcote FLP protective coating has hydrophilic properties. There are shown results of an automated processing of experimental data and comparison of the values of the coefficients of hydraulic friction, resistivity and roughness, which have been obtained at the large-sized and small-sized benches, as well as at a roughness indicator. Provision has been made of a possible and reasonable use of small-sized benches instead of large-sized ones for determination of hydrophoby and hydraulic parameters, which will considerably facilitate the traditional method of comprehensive estimation of the hydraulic performance of various types of protective coatings.

  9. Proceedings of the third nuclear thermal hydraulics meeting

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    This book contains the proceedings of the Thermal Hydraulics Division of the American Nuclear Society. The papers presented include: Simulator qualification using engineering codes and Development of thermal hydraulic analysis capabilities for Oyster Creek

  10. Chapter 12. Pure Tap Water Hydraulic Systems and Applications

    DEFF Research Database (Denmark)

    Conrad, Finn; Adelstorp, Anders

    1997-01-01

    Presentation of developed a modern pure tap water hydraulic components (Nessie), systems and industrial applications.......Presentation of developed a modern pure tap water hydraulic components (Nessie), systems and industrial applications....

  11. DCS Hydraulics Submittal, Otero County, New Mexico, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydraulics data includes spatial datasets and data tables necessary for documenting the hydraulic procedures for computing flood elevations for a flood insurance...

  12. Analysis of INDOT current hydraulic policies : [technical summary].

    Science.gov (United States)

    2011-01-01

    Hydraulic design often tends to be on a conservative side for safety reasons. Hydraulic structures are typically oversized with the goal being reduced future maintenance costs, and to reduce the risk of property owner complaints. This approach leads ...

  13. Applicability estimation of flowmeter logging for detecting hydraulic pass

    International Nuclear Information System (INIS)

    Miyakawa, Kimio; Tanaka, Yasuji; Tanaka, Kazuhiro

    1997-01-01

    Estimation of the hydraulic pass governing hydrogeological structure contributes significantly to the siting HLW repository. Flowmeter logging can detect hydraulic passes by measuring vertical flow velocity of groundwater in the borehole. We reviewed application of this logging in situ. The hydraulic pass was detected with combination of ambient flow logging, with pumping and/or injecting induced flow logging. This application showed that the flowmeter logging detected hydraulic passes conveniently and accurately compared with other hydraulic tests. Hydraulic conductivity by using flowmeter logging was assessed above 10 -6 m/sec and within one order from comparison with injection packer tests. We suggest that appropriate application of the flowmeter logging for the siting is conducted before hydraulic tests because test sections and monitoring sections are decided rationally for procurement of quantitative hydraulic data. (author)

  14. Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: a WHO-coordinated, prospective, international, observational cohort study.

    Science.gov (United States)

    Kleinschmidt, Immo; Bradley, John; Knox, Tessa Bellamy; Mnzava, Abraham Peter; Kafy, Hmooda Toto; Mbogo, Charles; Ismail, Bashir Adam; Bigoga, Jude D; Adechoubou, Alioun; Raghavendra, Kamaraju; Cook, Jackie; Malik, Elfatih M; Nkuni, Zinga José; Macdonald, Michael; Bayoh, Nabie; Ochomo, Eric; Fondjo, Etienne; Awono-Ambene, Herman Parfait; Etang, Josiane; Akogbeto, Martin; Bhatt, Rajendra M; Chourasia, Mehul Kumar; Swain, Dipak K; Kinyari, Teresa; Subramaniam, Krishanthi; Massougbodji, Achille; Okê-Sopoh, Mariam; Ogouyemi-Hounto, Aurore; Kouambeng, Celestin; Abdin, Mujahid Sheikhedin; West, Philippa; Elmardi, Khalid; Cornelie, Sylvie; Corbel, Vincent; Valecha, Neena; Mathenge, Evan; Kamau, Luna; Lines, Jonathan; Donnelly, Martin James

    2018-04-09

    Scale-up of insecticide-based interventions has averted more than 500 million malaria cases since 2000. Increasing insecticide resistance could herald a rebound in disease and mortality. We aimed to investigate whether insecticide resistance was associated with loss of effectiveness of long-lasting insecticidal nets and increased malaria disease burden. This WHO-coordinated, prospective, observational cohort study was done at 279 clusters (villages or groups of villages in which phenotypic resistance was measurable) in Benin, Cameroon, India, Kenya, and Sudan. Pyrethroid long-lasting insecticidal nets were the principal form of malaria vector control in all study areas; in Sudan this approach was supplemented by indoor residual spraying. Cohorts of children from randomly selected households in each cluster were recruited and followed up by community health workers to measure incidence of clinical malaria and prevalence of infection. Mosquitoes were assessed for susceptibility to pyrethroids using the standard WHO bioassay test. Country-specific results were combined using meta-analysis. Between June 2, 2012, and Nov 4, 2016, 40 000 children were enrolled and assessed for clinical incidence during 1·4 million follow-up visits. 80 000 mosquitoes were assessed for insecticide resistance. Long-lasting insecticidal net users had lower infection prevalence (adjusted odds ratio [OR] 0·63, 95% CI 0·51-0·78) and disease incidence (adjusted rate ratio [RR] 0·62, 0·41-0·94) than did non-users across a range of resistance levels. We found no evidence of an association between insecticide resistance and infection prevalence (adjusted OR 0·86, 0·70-1·06) or incidence (adjusted RR 0·89, 0·72-1·10). Users of nets, although significantly better protected than non-users, were nevertheless subject to high malaria infection risk (ranging from an average incidence in net users of 0·023, [95% CI 0·016-0·033] per person-year in India, to 0·80 [0·65-0·97] per person

  15. The advantages of hydraulic packing extraction

    International Nuclear Information System (INIS)

    Baker, R.S.

    1991-01-01

    Today's competitive environment, coupled with industry's desire to improve the efficiency of plant maintenance and operations, has management continually seeking ways to save time, money, and, at nuclear plants, radiation exposure. One area where a tremendous improvement in efficiency can be realized is valve packing removal. For example, industry experience indicates that up to 70% of the time it takes to repack a valve can be spent just removing the old packing. In some case, the bonnets of small valves are removed to facilitate packing removal and prevent stem and stuffing box damage that can occur when using packing removal picks. In other cases, small valves are simply removed and discarded because it costs less to replace the valves than to remove the packing using conventional methods. Hydraulic packing extraction greatly reduces packing removal time and will not damage the stem nor stuffing box, thus eliminating the need for bonnet removal or valve replacement. This paper will review some of the more common problems associated with manual packing extraction techniques. It will explain how hydraulic packing extraction eliminates or greatly reduces the impact of each of the problem areas. A discussion will be provided of some actual industry operating experiences related to success stories using hydraulic packing extraction. The paper will also briefly describe the operating parameters associated with hydraulic packing extraction tools. Throughout the paper, actual operating experiences from the nuclear power, fossil power, petrochemical, and refinery industries will be used to support the conclusion that hydraulic packing extraction is an alternative that can save time, money, and exposure

  16. Understanding, Classifying, and Selecting Environmentally Acceptable Hydraulic Fluids

    Science.gov (United States)

    2016-08-01

    traditional mineral oil; therefore, the life cycle costs over time may be reduced . REPLACEMENT OF EXISTING HYDRAULIC FLUIDS: Hydraulic fluids in existing...properly maintaining the fluid can extend the time interval between fluid changes, thus reducing the overall operating cost of the EA hydraulic fluid. It...Environmentally Acceptable Hydraulic Fluids by Timothy J. Keyser, Robert N. Samuel, and Timothy L. Welp INTRODUCTION: On a daily basis, the United States Army

  17. Review of fluid and control technology of hydraulic wind turbines

    Science.gov (United States)

    Cai, Maolin; Wang, Yixuan; Jiao, Zongxia; Shi, Yan

    2017-09-01

    This study examines the development of the fluid and control technology of hydraulic wind turbines. The current state of hydraulic wind turbines as a new technology is described, and its basic fluid model and typical control method are expounded by comparing various study results. Finally, the advantages of hydraulic wind turbines are enumerated. Hydraulic wind turbines are expected to become the main development direction of wind turbines.

  18. Review of fluid and control technology of hydraulic wind turbines

    Institute of Scientific and Technical Information of China (English)

    Maolin CAI; Yixuan WANG; Zongxia JIAO; Yan SHI

    2017-01-01

    This study examines the development of the fluid and control technology of hydraulic wind turbines.The current state of hydraulic wind turbines as a new technology is described,and its basic fluid model and typical control method are expounded by comparing various study results.Finally,the advantages of hydraulic wind turbines are enumerated.Hydraulic wind turbines are expected to become the main development direction of wind turbines.

  19. Critical review of hydraulic modeling on atmospheric heat dissipation

    International Nuclear Information System (INIS)

    Onishi, Y.; Brown, S.M.

    1977-01-01

    Objectives of this study were: to define the useful roles of hydraulic modeling in understanding the predicting atmospheric effects of heat dissipation systems; to assess the state-of-the-art of hydraulic modeling of atmospheric phenomena; to inventory potentially useful existing hydraulic modeling facilities both in the United States and abroad; and to scope hydraulic model studies to assist the assessment of atmospheric effects of nuclear energy centers

  20. Interactions of tillage and cover crop on water, sediment, and pre-emergence herbicide loss in glyphosate-resistant cotton: implications for the control of glyphosate-resistant weed biotypes.

    Science.gov (United States)

    Krutz, L Jason; Locke, Martin A; Steinriede, R Wade

    2009-01-01

    The need to control glyphosate [N-(phosphonomethyl)glycine]-resistant weed biotypes with tillage and preemergence herbicides in glyphosate-resistant crops (GRCs) is causing a reduction in no-tillage hectarage thereby threatening the advances made in water quality over the past decade. Consequently, if environmental gains afforded by GRCs are to be maintained, then an in-field best management practice (BMP) compatible with tillage is required for hectarage infested with glyphosate-resistant weed biotypes. Thus, 1 d after a preemergent application of fluometuron [N,N-dimethyl-N'-(3-(trifluoromethyl)phenyl)urea] (1.02 kg ha(-1)) and metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide] (1.18 kg ha(-1)) to a Dundee silt loam (fine-silty, mixed, active, thermic Typic Endoaqualf), simulated rainfall (60 mm h(-1)) was applied to 0.0002-ha microplots for approximately 1.25 h to elucidate tillage (no tillage [NT] and reduced tillage [RT])and cover crop (no cover [NC] and rye cover [RC]) effects on water, sediment, and herbicide loss in surface runoff. Regardless of tillage, RC delayed time-to-runoff 1.3-fold, reduced cumulative runoff volume 1.4-fold, and decreased cumulative sediment loss 4.7-fold. Cumulative fluometuron loss was not affected by tillage or cover crop. Conversely, total metolachlor loss was 1.3-fold lower in NT than RT and 1.4-fold lower in RC than NC. These data indicate that RC can be established in hectarage requiring tillage and potentially curtail water, sediment, and preemergence herbicide losses in the spring to levels equivalent to or better than that of NT, thereby protecting environmental gains provided by GRCs.

  1. A Hydraulic Stress Measurement System for Investigations at Depth in Slim Boreholes

    Science.gov (United States)

    Ask, M. V. S.; Ask, D.; Cornet, F. H.; Nilsson, T.; Talib, M.; Sundberg, J.

    2017-12-01

    Knowledge of the state of stress is essential to most underground work in rock mechanics as it provides means to analyze the mechanical behavior of a rock mass, serve as boundary condition in rock engineering problems, and help understand rock mass stability and groundwater flow. Luleå University of Technology (LTU) has developed and built a wire-line system for hydraulic rock stress measurements in slim boreholes together with the University of Strasbourg and Geosigma AB. The system consists of a downhole- and a surface unit. The downhole unit consists of hydraulic fracturing equipment (straddle packers and downhole imaging tool) and their associated data acquisition systems. The surface unit comprises of a 40-foot container permanently mounted on a trailer, which is equipped with a tripod, wire-line winches, water hydraulics, and a generator. The surface unit serves as a climate-independent on-site operations center, as well as a self-supporting transport vessel for the entire system. Three hydraulic stress testing methods can be applied: hydraulic fracturing, sleeve fracturing and hydraulic testing of pre-existing fractures. The three-dimensional stress tensor and its variation with depth within a continuous rock mass can be determined in a scientific unambiguously way by integrating results from the three test methods. The testing system is state of the art in several aspects including: (1) Large depth range (3 km), (2) Ability to test three borehole dimensions, (3) Resistivity imager maps the orientation of tested fracture (which is highlighted); (4) Highly stiff and resistive to corrosion downhole testing equipment; and (5) Very detailed control on the injection flow rate and cumulative volume is obtained by a hydraulic injection pump with variable piston rate, and a highly sensitive flow-meter. These aspects highly reduce measurement-related uncertainties of stress determination. Commissioning testing and initial field tests are scheduled to occur in a 1200

  2. 14 CFR 33.72 - Hydraulic actuating systems.

    Science.gov (United States)

    2010-01-01

    ... AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; Turbine Aircraft Engines § 33.72 Hydraulic actuating systems. Each hydraulic actuating system must function properly under all conditions in which the... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Hydraulic actuating systems. 33.72 Section...

  3. Core Thermal-Hydraulic Conceptual Design for the Advanced SFR Design Concepts

    International Nuclear Information System (INIS)

    Cho, Chung Ho; Chang, Jin Wook; Yoo, Jae Woon; Song, Hoon; Choi, Sun Rock; Park, Won Seok; Kim, Sang Ji

    2010-01-01

    The Korea Atomic Energy Research Institute (KAERI) has developed the advanced SFR design concepts from 2007 to 2009 under the National longterm Nuclear R and D Program. Two types of core designs, 1,200 MWe breakeven and 600 MWe TRU burner core have been proposed and evaluated whether they meet the design requirements for the Gen IV technology goals of sustainability, safety and reliability, economics, proliferation resistance, and physical protection. In generally, the core thermal hydraulic design is performed during the conceptual design phase to efficiently extract the core thermal power by distributing the appropriate sodium coolant flow according to the power of each assembly because the conventional SFR core is composed of hundreds of ducted assemblies with hundreds of fuel rods. In carrying out the thermal and hydraulic design, special attention has to be paid to several performance parameters in order to assure proper performance and safety of fuel and core; the coolant boiling, fuel melting, structural integrity of the components, fuel-cladding eutectic melting, etc. The overall conceptual design procedure for core thermal and hydraulic conceptual design, i.e., flow grouping and peak pin temperature calculations, pressure drop calculations, steady-state and detailed sub-channel analysis is shown Figure 1. In the conceptual design phase, results of core thermal-hydraulic design for advanced design concepts, the core flow grouping, peak pin cladding mid-wall temperature, and pressure drop calculations, are summarized in this study

  4. Hydraulic properties of rice and the response of gas exchange to water stress.

    Science.gov (United States)

    Stiller, Volker; Lafitte, H Renee; Sperry, John S

    2003-07-01

    We investigated the role of xylem cavitation, plant hydraulic conductance, and root pressure in the response of rice (Oryza sativa) gas exchange to water stress. In the field (Philippines), the percentage loss of xylem conductivity (PLC) from cavitation exceeded 60% in leaves even in watered controls. The PLC versus leaf water potential relationship indicated diurnal refilling of cavitated xylem. The leaf water potential causing 50 PLC (P(50)) was -1.6 MPa and did not differ between upland versus lowland rice varieties. Greenhouse-grown varieties (Utah) were more resistant to cavitation with a 50 PLC of -1.9 MPa but also showed no difference between varieties. Six-day droughts caused concomitant reductions in leaf-specific photosynthetic rate, leaf diffusive conductance, and soil-leaf hydraulic conductance that were associated with cavitation-inducing water potentials and the disappearance of nightly root pressure. The return of root pressure after drought was associated with the complete recovery of leaf diffusive conductance, leaf-specific photosynthetic rate, and soil-leaf hydraulic conductance. Root pressure after the 6-d drought (61.2 +/- 8.8 kPa) was stimulated 7-fold compared with well-watered plants before drought (8.5 +/- 3.8 kPa). The results indicate: (a) that xylem cavitation plays a major role in the reduction of plant hydraulic conductance during drought, and (b) that rice can readily reverse cavitation, possibly aided by nocturnal root pressure.

  5. Application of hydraulic network analysis to motor operated butterfly valves in nuclear power plants

    International Nuclear Information System (INIS)

    Eldiwany, B.H.; Kalsi, M.S.

    1992-01-01

    This paper presents the application of hydraulic network analysis to evaluate the performance of butterfly valves in nuclear power plant applications. Required actuation torque for butterfly valves in high-flow applications is often dictated by peak dynamic torque. The peak dynamic torque, which occurs at some intermediate disc position, requires accurate evaluation of valve flow rate and pressure drop throughout the valve stroke. Valve flow rate and pressure drop are significantly affected by the valve flow characteristics and the hydraulic system characteristics, such as pumping capability, piping resistances, single and parallel flow paths, system hydrostatic pressure, and the location of the motor-operated valve (MOV) within the system. A hydraulic network analysis methodology that addresses the effect of these parameters on the MOV performance is presented. The methodology is based on well-established engineering principles. The application of this methodology requires detailed characteristics of both the MOV and the hydraulic system in which it is installed. The valve characteristics for this analysis can be obtained by flow testing or from the valve manufacturer. Even though many valve users, valve manufacturers, and engineering standards have recognized the importance of performing these analyses, none has provided a detailed procedure for doing so

  6. Spread of community-acquired meticillin-resistant Staphylococcus aureus skin and soft-tissue infection within a family: implications for antibiotic therapy and prevention.

    LENUS (Irish Health Repository)

    Amir, N H

    2010-04-01

    Outbreaks or clusters of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) within families have been reported. We describe a family cluster of CA-MRSA skin and soft-tissue infection where CA-MRSA was suspected because of recurrent infections which failed to respond to flucloxacillin. While the prevalence of CA-MRSA is low worldwide, CA-MRSA should be considered in certain circumstances depending on clinical presentation and risk assessment. Surveillance cultures of family contacts of patients with MRSA should be considered to help establish the prevalence of CA-MRSA and to inform the optimal choice of empiric antibiotic treatment.

  7. Project calculation of the steering mechanism hydraulic servo control in motor vehicles

    Directory of Open Access Journals (Sweden)

    Zoran Đukan Majkić

    2013-10-01

    Full Text Available Hydraulic servo controls are designed to facilitate rotation in place without providing increased ppower to steering wheels. In the initial design phase, the dimensions required for control systems are usually obtained through the calculation of their load when wheels rotate in place, where the torque is calculated empirically. The starting point in the project calculation is thus to determine the hydraulic power steering torque torsional resistance which is then used to determine the maximum value of force i.e. the torque on the stering wheel. The calculation of the control system servo control consists of determining the basic parameters, the required pump capacity, the main dimensions of the hub and the  pipeline and the conditions for the stability of the system control mechanism. Introduction The aim of the calculation of the steering control system is to determine the basic parameters of its components which ensure the fulfilment of requirements of the control system. Calculations are performed in several stages with a simultaneous  detailed constructive analysis of the control system leading to the best variant. At each stage, design and control calculations of the hydraulic servo of the steering mechanism are performed. The design allows the computation to complete the selection of basic dimensions of the amplifer elements, starting from the approved scheme and the basic building loads of approximate values. Calculations control is carried out to clarify the structural solution and to obtain the output characteristics of the control amplifier which are applied in the  estimation of  potential properties of the structure. Project calculation Baseline data must be sufficiently reliable, ie. must correspond to the construction characteristics of the vehicle design and the control system as well as to service conditions..A proper deterimination of the torque calculation of torsional resistance in wheels is of utmost importance. Moment of

  8. Falciparum malaria in the north of Laos: the occurrence and implications of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene haplotype SVMNT

    DEFF Research Database (Denmark)

    Dittrich, Sabine; Alifrangis, Michael; Stohrer, Jörg M

    2005-01-01

    the SVMNT haplotype. METHOD: Eighty-eight samples from an area with reported in vivo Chloroquine and in vitro Amodiaquine-resistance were screened for the K76T mutation and their Pfcrt-haplotype (c72-76) using a new SSOP-ELISA. RESULTS: Hundred percent of the analysed samples showed the K76T mutation which......OBJECTIVE: The Pfcrt-gene encodes a transmembrane protein located in the Plasmodium falciparum digestive vacuole. Chloroquine resistant (CQR) strains of African and Southeast Asian origin carry the Pfcrt-haplotype (c72-76) CVIET, whereas most South American and Papua New Guinean CQR stains carry...... is highly associated with in vivo drug failure. This very high rate of a CQR-marker is alarming in an area were CQ is still used as first line drug. The distribution of the three main Pfcrt-haplotypes was as follows: 68% CVIET, 31% SVMNT, 0% CVMNT. CONCLUSIONS: These data show, for the first time, the South...

  9. Synthesis of Servo Pneumatic/Hydraulic Drive

    Directory of Open Access Journals (Sweden)

    K D. Efremova

    2017-01-01

    Full Text Available Servo pneumatic and / or hydraulic drives are widely used in modern engineering and process control. The efficiency of using pneumatic / hydraulic drives depends on their parameters and characteristics. To select the optimal drive parameters, various methods are used, based on finding the minimum of the target (target or criteria function.The objective of this paper was to apply one crucial criterion (target function that provides determination of optimal parameters of the pneumatic / hydraulic drive with the translational motion of the end-effector as well as its use in the synthesis of the servo pneumatic cylinder. The article shows the form of the target function representing a set of drive parameters that do not have direct relationships with each other in a dimensionless form for the pneumatic / hydraulic drive with the translational motion of the end-effector. To calculate the parameters of the servo drive close to the optimal ones, a two-criteria LPτ search was used. As criteria, were used the decisive criterion - the proposed target function, and the power developed by the actuator of the pneumatic / hydraulic drive, which were presented in a dimensionless form. It is shown that the criterion for solution optimality is the minimum distance of the selected point in the space of the normalized criteria from the origin. This point was determined. In addition to the proposed criteria, non-formalised requirements were taken into account: actual and mass-produced components of drive, in terms of which its parameters close to the optimal ones were determined, and the maximum relative error of the obtained useful power value of the servo pneumatic drive was estimated. The paper presents design features of two types of the servo pneumatic drive created, taking into account the proposed target function, implemented according to the schemes "hidden" and "spaced apart". The experimental static characteristic of the servo pneumatic drive is

  10. Hydraulic Limits on Maximum Plant Transpiration

    Science.gov (United States)

    Manzoni, S.; Vico, G.; Katul, G. G.; Palmroth, S.; Jackson, R. B.; Porporato, A. M.

    2011-12-01

    Photosynthesis occurs at the expense of water losses through transpiration. As a consequence of this basic carbon-water interaction at the leaf level, plant growth and ecosystem carbon exchanges are tightly coupled to transpiration. In this contribution, the hydraulic constraints that limit transpiration rates under well-watered conditions are examined across plant functional types and climates. The potential water flow through plants is proportional to both xylem hydraulic conductivity (which depends on plant carbon economy) and the difference in water potential between the soil and the atmosphere (the driving force that pulls water from the soil). Differently from previous works, we study how this potential flux changes with the amplitude of the driving force (i.e., we focus on xylem properties and not on stomatal regulation). Xylem hydraulic conductivity decreases as the driving force increases due to cavitation of the tissues. As a result of this negative feedback, more negative leaf (and xylem) water potentials would provide a stronger driving force for water transport, while at the same time limiting xylem hydraulic conductivity due to cavitation. Here, the leaf water potential value that allows an optimum balance between driving force and xylem conductivity is quantified, thus defining the maximum transpiration rate that can be sustained by the soil-to-leaf hydraulic system. To apply the proposed framework at the global scale, a novel database of xylem conductivity and cavitation vulnerability across plant types and biomes is developed. Conductivity and water potential at 50% cavitation are shown to be complementary (in particular between angiosperms and conifers), suggesting a tradeoff between transport efficiency and hydraulic safety. Plants from warmer and drier biomes tend to achieve larger maximum transpiration than plants growing in environments with lower atmospheric water demand. The predicted maximum transpiration and the corresponding leaf water

  11. Hydraulics and pneumatics a technician's and engineer's guide

    CERN Document Server

    Parr, Andrew

    1991-01-01

    Hydraulics and Pneumatics: A Technician's and Engineer's Guide provides an introduction to the components and operation of a hydraulic or pneumatic system. This book discusses the main advantages and disadvantages of pneumatic or hydraulic systems.Organized into eight chapters, this book begins with an overview of industrial prime movers. This text then examines the three different types of positive displacement pump used in hydraulic systems, namely, gear pumps, vane pumps, and piston pumps. Other chapters consider the pressure in a hydraulic system, which can be quickly and easily controlled

  12. Observations of a potential size-effect in experimental determination of the hydraulic properties of fractures

    International Nuclear Information System (INIS)

    Witherspoon, P.A.; Amick, C.H.; Gale, J.E.; Iwai, K.

    1979-05-01

    In several recent investigations, experimental studies on the effect of normal stress on the hydraulic conductivity of a single fracture were made on three rock specimens ranging in cross-sectional area from 0.02 m 2 to over 1.0 m 2 . At the maximum stress levels that could be attained (10 to 20 MPa), minimum values of the fracture hydraulic conductivity were not the same for each rock specimen. These minimum values increased with specimen size, indicating that the determination of fracture conductivity may be significantly influenced by a size effect. The implications of these results are important. Cores collected in the field are normally not larger than 0.15 m in diameter. However, the results of this work suggest that when this size core is used for laboratory investigations, the results may be nonconservative in that fracture permeabilities will be significantly lower than will be found in the field. 6 figures

  13. TG 220 MW hydraulic control system diagnostics

    International Nuclear Information System (INIS)

    Svabcik, A.

    1996-01-01

    The TG power output control system comprises a hydraulic and an electronic part. TG speed, power output or the main steam header pressure (HPK) depend on the steam flow at the turbine inlet. The steam admission into the turbine is controlled by four control valves and one by-pass valve in case of the HP part and by four capture flap valves in case of the LP part. The task of the SKODA K-220 MW turbine protection and control systems is to provide both the turbine speed and power output control to the setpoint value. Diagnostic measurements were aimed at getting an overview of both technical and functional states of all power output control elements. Principally, it can be stated that some deficiencies of a design nature originating from the manufacturer's factory were revealed and some other deficiencies related to hydraulic control elements functionality were identified more closely by the new method. 5 figs

  14. TG 220 MW hydraulic control system diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Svabcik, A [Atomova Elektraren Bohunice, Jaslovske Bohunice (Slovakia)

    1997-12-31

    The TG power output control system comprises a hydraulic and an electronic part. TG speed, power output or the main steam header pressure (HPK) depend on the steam flow at the turbine inlet. The steam admission into the turbine is controlled by four control valves and one by-pass valve in case of the HP part and by four capture flap valves in case of the LP part. The task of the SKODA K-220 MW turbine protection and control systems is to provide both the turbine speed and power output control to the setpoint value. Diagnostic measurements were aimed at getting an overview of both technical and functional states of all power output control elements. Principally, it can be stated that some deficiencies of a design nature originating from the manufacturer`s factory were revealed and some other deficiencies related to hydraulic control elements functionality were identified more closely by the new method. 5 figs.

  15. Pilot testing of a hydraulic bridge exciter

    Directory of Open Access Journals (Sweden)

    Andersson Andreas

    2015-01-01

    Full Text Available This paper describes the development of a hydraulic bridge exciter and its first pilot testing on a full scale railway bridge in service. The exciter is based on a hydraulic load cylinder with a capacity of 50 kN and is intended for controlled dynamic loading up to at least 50 Hz. The load is applied from underneath the bridge, enabling testing while the railway line is in service. The system is shown to produce constant load amplitude even at resonance. The exciter is used to experimentally determine frequency response functions at all sensor locations, which serve as valuable input for model updating and verification. An FE-model of the case study bridge has been developed that is in good agreement with the experimental results.

  16. Hydraulic and Wave Aspects of Novorossiysk Bora

    Science.gov (United States)

    Shestakova, Anna A.; Moiseenko, Konstantin B.; Toropov, Pavel A.

    2018-02-01

    Bora in Novorossiysk (seaport on the Black Sea coast of the Caucasus) is one of the strongest and most prominent downslope windstorms on the territory of Russia. In this paper, we evaluate the applicability of the hydraulic and wave hypotheses, which are widely used for downslope winds around the world, to Novorossiysk bora on the basis of observational data, reanalysis, and mesoscale numerical modeling with WRF-ARW. It is shown that mechanism of formation of Novorossiysk bora is essentially mixed, which is expressed in the simultaneous presence of gravity waves breaking and a hydraulic jump, as well as in the significant variability of the contribution of wave processes to the windstorm dynamics. Effectiveness of each mechanism depends on the elevated inversion intensity and mean state critical level height. Most favorable conditions for both mechanisms working together are moderate or weak inversion and high or absent critical level.

  17. Concept Evaluation for Hydraulic Yaw System

    DEFF Research Database (Denmark)

    Stubkier, Søren; Pedersen, Henrik C.; Andersen, Torben Ole

    2013-01-01

    The yaw system is the subsystem on a wind turbine which ensures that the rotor plane of the turbine always is facing the wind direction. Studies from [1] show that a soft yaw system may be utilized to dampen the loads in the wind turbine structure. The soft yaw system operates much like...... investigation. Loads and yaw demands are based on the IEC 61400-1 standard for wind turbine design, and the loads for this examination are extrapolated from the HAWC2 aeroelastic design code. The concepts are based on a 5 MW off-shore turbine....... a suspension system on a car, leading the loads away from the turbine structure. However, to realize a soft hydraulic yaw system a new design concept must be found. As a part of the development of the new concept a preliminary concept evaluation has been conducted, evaluating seven different hydraulic yaw...

  18. Trends in Design of Water Hydraulics

    DEFF Research Database (Denmark)

    Conrad, Finn

    2005-01-01

    ordinary tap water and the range of application areas are illustrated with examples, in particular within the food processing industry, humidification operations, water mist systems for fire fighting, high water pressure cleaners, water moisturising systems for wood processing, lumber drying process...... operate with pure water from the tap without additives of any kind. Hence water hydraulics takes the benefit of pure water as fluid being environmentally friendly, easy to clean sanitary design, non-toxic, non-flammable, inexpensive, readily available and easily disposable. The low-pressure tap water...... and accessories running with sea-water as fluid are available. A unique solution is to use reverse osmosis to generate drinking water from sea-water, and furthermore for several off-shore applications. Furthermore, tap water hydraulic components of the Nessie® family and examples of measured performance...

  19. Thermal Hydraulic Design of PWT Accelerating Structures

    CERN Document Server

    Yu, David; Chen Ping; Lundquist, Martin; Luo, Yan

    2005-01-01

    Microwave power losses on the surfaces of accelerating structures will transform to heat which will deform the structures if it is not removed in time. Thermal hydraulic design of the disk and cooling rods of a Plane Wave Transformer (PWT) structure is presented. Experiments to measure the hydraulic (pressure vs flow rate) and cooling (heat removed vs flow rate) properties of the PWT disk are performed, and results compared with simulations using Mathcad models and the COSMOSM code. Both experimental and simulation results showed that the heat deposited on the structure could be removed effectively using specially designed water-cooling circuits and the temperature of the structure could be controlled within the range required.

  20. A boost to the French hydraulic plan

    International Nuclear Information System (INIS)

    2008-01-01

    A plan for boosting the hydroelectric power generation in France is presented, the first step of an energy policy based on the conclusions of the Grenelle Environnement Forum which targets a 23 percent objective for the renewable energies in France by 2020. Hydroelectricity represents nowadays 12 percent of total electric power generation. The plan is composed of three parts: attribution of concessions will be opened to competition (concessions of the 400 largest dams will be renewed); investments in dams will be strongly encouraged and assisted by the government in order to increase France's hydraulic power generation capacities and enhance its security of power supply - small and micro hydraulic power generation is to be developed; the quality of river waters will be improved

  1. Soil hydraulic properties of Cuban soils

    International Nuclear Information System (INIS)

    Ruiz, M.E.; Medina, H.

    2004-01-01

    Because soil hydraulic properties are indispensable for determining soil water retention and soil water movement, their input for deterministic crop simulation models is essential. From these models is possible to access the effect of the weather changes, soil type or different irrigation schedules on crop yields. With these models, possibilities are provided to answer questions regarding virtual 'what happen if' experiments with a minimum of fieldwork. Nevertheless, determining soil hydraulic properties can be very difficult owing to unavailability of necessary equipment or the lack of personal with the proper knowledge for those tasks. These deficiencies are a real problem in developing countries, and even more so when there is not enough financial possibilities for research work. This paper briefly presents the way these properties have been accessed for Cuban soils, which methods have been used and the work now in progress. (author)

  2. Analysis of uncertainties of thermal hydraulic calculations

    International Nuclear Information System (INIS)

    Macek, J.; Vavrin, J.

    2002-12-01

    In 1993-1997 it was proposed, within OECD projects, that a common program should be set up for uncertainty analysis by a probabilistic method based on a non-parametric statistical approach for system computer codes such as RELAP, ATHLET and CATHARE and that a method should be developed for statistical analysis of experimental databases for the preparation of the input deck and statistical analysis of the output calculation results. Software for such statistical analyses would then have to be processed as individual tools independent of the computer codes used for the thermal hydraulic analysis and programs for uncertainty analysis. In this context, a method for estimation of a thermal hydraulic calculation is outlined and selected methods of statistical analysis of uncertainties are described, including methods for prediction accuracy assessment based on the discrete Fourier transformation principle. (author)

  3. Thermal hydraulics in undergraduate nuclear engineering education

    International Nuclear Information System (INIS)

    Theofanous, T.G.

    1986-01-01

    The intense safety-related research efforts of the seventies in reactor thermal hydraulics have brought about the recognition of the subject as one of the cornerstones of nuclear engineering. Many nuclear engineering departments responded by building up research programs in this area, and mostly as a consequence, educational programs, too. Whether thermal hydraulics has fully permeated the conscience of nuclear engineering, however, remains yet to be seen. The lean years that lie immediately ahead will provide the test. The purpose of this presentation is to discuss the author's own educational activity in undergraduate nuclear engineering education over the past 10 yr or so. All this activity took place at Purdue's School of Nuclear Engineering. He was well satisfied with the results and expects to implement something similar at the University of California in Santa Barbara in the near future

  4. Thermal-hydraulic analysis of nuclear reactors

    CERN Document Server

    Zohuri, Bahman

    2015-01-01

    This text covers the fundamentals of thermodynamics required to understand electrical power generation systems and the application of these principles to nuclear reactor power plant systems. It is not a traditional general thermodynamics text, per se, but a practical thermodynamics volume intended to explain the fundamentals and apply them to the challenges facing actual nuclear power plants systems, where thermal hydraulics comes to play.  Written in a lucid, straight-forward style while retaining scientific rigor, the content is accessible to upper division undergraduate students and aimed at practicing engineers in nuclear power facilities and engineering scientists and technicians in industry, academic research groups, and national laboratories. The book is also a valuable resource for students and faculty in various engineering programs concerned with nuclear reactors. This book also: Provides extensive coverage of thermal hydraulics with thermodynamics in nuclear reactors, beginning with fundamental ...

  5. New parameters influencing hydraulic runner lifetime

    International Nuclear Information System (INIS)

    Sabourin, M; Bouffard, D A; Thibault, D; Levesque, M

    2010-01-01

    Traditionally, hydraulic runner mechanical design is based on calculation of static stresses. Today, validation of hydraulic runner design in terms of reliability requires taking into account the fatigue effect of dynamics loads. A damage tolerant approach based on fracture mechanics is the method chosen by Alstom and Hydro-Quebec to study fatigue damage in runners. This requires a careful examination of all factors influencing material fatigue behavior. Such material behavior depends mainly on the chemical composition, microstructure and thermal history of the component, and on the resulting residual stresses. Measurement of fracture mechanics properties of various steels have demonstrated that runner lifetime can be significantly altered by differences in the manufacturing process, although remaining in accordance with agreed practices and standards such as ASTM. Carbon content and heat treatment are suspected to influence fatigue lifetime. This will have to be investigated by continuing the current research.

  6. New parameters influencing hydraulic runner lifetime

    Energy Technology Data Exchange (ETDEWEB)

    Sabourin, M; Bouffard, D A [Alstom Hydro Canada Inc, Hydraulic Engineering, 1350 chemin St-Roch, Sorel-Tracy (Quebec), J3P 5P9 (Canada); Thibault, D [Hydro-Quebec, Institut de Recherche d' Hydro-Quebec 1800 boul. Lionel-Boulet, Varennes (Quebec), J3X 1S1 (Canada); Levesque, M, E-mail: michel.sabourin@power.alstom.co [Ecole Polytechnique de Montreal, Departement de genie mecanique C.P.6079, succ. Centre-ville, Montreal (Quebec), H3C 3A7 (Canada)

    2010-08-15

    Traditionally, hydraulic runner mechanical design is based on calculation of static stresses. Today, validation of hydraulic runner design in terms of reliability requires taking into account the fatigue effect of dynamics loads. A damage tolerant approach based on fracture mechanics is the method chosen by Alstom and Hydro-Quebec to study fatigue damage in runners. This requires a careful examination of all factors influencing material fatigue behavior. Such material behavior depends mainly on the chemical composition, microstructure and thermal history of the component, and on the resulting residual stresses. Measurement of fracture mechanics properties of various steels have demonstrated that runner lifetime can be significantly altered by differences in the manufacturing process, although remaining in accordance with agreed practices and standards such as ASTM. Carbon content and heat treatment are suspected to influence fatigue lifetime. This will have to be investigated by continuing the current research.

  7. A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease

    Directory of Open Access Journals (Sweden)

    Franziska C. Sandmeier

    2012-08-01

    Vertebrate immune systems are understood to be complex and dynamic, with trade-offs among different physiological components (e.g., innate and adaptive immunity within individuals and among taxonomic lineages. Desert tortoises (Gopherus agassizii immunised with ovalbumin (OVA showed a clear trade-off between levels of natural antibodies (NAbs; innate immune function and the production of acquired antibodies (adaptive immune function. Once initiated, acquired antibody responses included a long-term elevation in antibodies persisting for more than one year. The occurrence of either (a high levels of NAbs or (b long-term elevations of acquired antibodies in individual tortoises suggests that long-term humoral resistance to pathogens may be especially important in this species, as well as in other vertebrates with slow metabolic rates, concomitantly slow primary adaptive immune responses, and long life-spans.

  8. Survival and Development of Spodoptera frugiperda and Chrysodeixis includens (Lepidoptera: Noctuidae) on Bt Cotton and Implications for Resistance Management Strategies in Brazil.

    Science.gov (United States)

    Sorgatto, Rodrigo J; Bernardi, Oderlei; Omoto, Celso

    2015-02-01

    In Brazil, Spodoptera frugiperda (J. E. Smith) and Chrysodeixis includens (Walker) are important cotton pests and target of control of Bollgard II (Cry1Ac/Cry2Ab2) and WideStrike (Cry1Ac/Cry1F) cotton technologies. To subsidize an insect resistance management program, we conducted laboratory studies to evaluate the toxicity of these Bt cotton plants throughout larval development of S. frugiperda and C. includens. In bioassays with leaf disc, the efficacy of both Bt cotton plants against neonates was >80% for S. frugiperda and 100% for C. includens. However, S. frugiperda larvae that survived on Bt cotton had >76% of growth inhibition and stunting. In bioassays with S. frugiperda and C. includens larvae fed on non-Bt near-isoline during different time period (from 3 to 18 d) and then transferred to Bollgard II or WideStrike leaves showed that larval susceptibility decreased as larval age increased. For Bollgard II cotton, in all S. frugiperda instars, there were larvae that reached the pupal and adult stages. In contrast, on WideStrike cotton, a few larvae in fifth and sixth instar completed the biological cycle. For C. includens, some larvae in sixth instar originated adults in both Bt cotton plants. In conclusion, Bollgard II and WideStrike cotton technologies showed high efficacy against neonates of S. frugiperda and C. includens. However, the mortality of these species decreases as larval age increase, allowing insect survival in a possible seed mixture environment and favoring the resistance evolution. © The Author 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  9. Effect of insecticides and Plutella xylostella (Lepidoptera: Plutellidae) genotype on a predator and parasitoid and implications for the evolution of insecticide resistance.

    Science.gov (United States)

    Liu, Xiaoxia; Chen, Mao; Collins, Hilda L; Onstad, David; Roush, Rick; Zhang, Qingwen; Shelton, Anthony M

    2012-04-01

    In the laboratory and in cages in the greenhouse, we evaluated the toxicity of two insecticides (lambda-cyhalothrin and spinosad) on the parasitoid, Diadegma insulare (Cresson), and the predator, Coleomegilla maculate (DeGeer), both natural enemies of the diamondback moth, Plutella xylostella (L.). Lambda-cyhalothrin was very toxic to both natural enemies. Spinosad was less toxic to C. maculata adults and larvae, and slightly toxic to D. insulare. Both natural enemies suppressed P. xylostella populations in cages with 80% spinosad-treated and 20% nontreated plants; such suppression was not seen when lambda-cyhalothrin was used. Using broccoli, Brassica oleracea L. variety italica, a common host for P. xylostella, we also studied direct and indirect effects of both natural enemies in the presence and absence of the two insecticides and to different P. xylostella genotypes: resistant to the insecticide, susceptible, or heterozygous. Neither natural enemy could distinguish host genotype if P. xylostella were feeding on nontreated plants. They could also not distinguish between larvae feeding on spinosad-treated plants and nontreated plants, but D. insulare could distinguish between larvae feeding on lambda-cyhalothrin treated and nontreated plants. Our studies suggest that lambda-cyhalothrin has direct toxicity to these two natural enemies, can affect their host foraging and acceptance of P. xylostella and consequently would not be compatible in conserving these natural enemies in a program for suppression of P. xylostella. In contrast, our studies suggest that treatment with spinosad has much less effect on these natural enemies and would allow them to help suppress populations of P. xylostella. These findings are discussed in relation to the evolution of insecticide resistance and suppression of the pest populations.

  10. The micro hydraulic power, a sure value

    International Nuclear Information System (INIS)

    Anon.

    2003-01-01

    The micro hydroelectricity is a proven technology which has now reached maturity. Ideal for electrification of remote sites, it also serves a complement to national electric production. A recent study carried out by the ESHA estimates the potential which still available in terms of micro hydraulic power plants at 5939 MW. The small hydro power capacity (>10 MW) installed in European union and the available potential of small hydro power are presented. (A.L.B.)

  11. Hydraulic Study For Kuala Sungai Kemaman

    International Nuclear Information System (INIS)

    Siti Aishah Hashim

    2006-01-01

    Hydraulic study for Kuala Sungai Kemaman is carried out to determine the cause of sedimentation at the river mouth and erosion of the shoreline south of the Kuala Sungai Kemaman. Computer model MIKE 21 is used in this study. The modeling work consist of setting up the model area, calibration and verification of the model, sedimentation study and review several alternatives and chose the most suitable one to solve the sedimentation and erosion problem. (Author)

  12. Virginia Power thermal-hydraulics methods

    International Nuclear Information System (INIS)

    Anderson, R.C.; Basehore, K.L.; Harrell, J.R.

    1987-01-01

    Virginia Power's nuclear safety analysis group is responsible for the safety analysis of reload cores for the Surry and North Anna power stations, including the area of core thermal-hydraulics. Postulated accidents are evaluated for potential departure from nucleate boiling violations. In support of these tasks, Virginia Power has employed the COBRA code and the W-3 and WRB-1 DNB correlations. A statistical DNBR methodology has also been developed. The code, correlations and statistical methodology are discussed

  13. Estimation of ground water hydraulic parameters

    Energy Technology Data Exchange (ETDEWEB)

    Hvilshoej, Soeren

    1998-11-01

    The main objective was to assess field methods to determine ground water hydraulic parameters and to develop and apply new analysis methods to selected field techniques. A field site in Vejen, Denmark, which previously has been intensively investigated on the basis of a large amount of mini slug tests and tracer tests, was chosen for experimental application and evaluation. Particular interest was in analysing partially penetrating pumping tests and a recently proposed single-well dipole test. Three wells were constructed in which partially penetrating pumping tests and multi-level single-well dipole tests were performed. In addition, multi-level slug tests, flow meter tests, gamma-logs, and geologic characterisation of soil samples were carried out. In addition to the three Vejen analyses, data from previously published partially penetrating pumping tests were analysed assuming homogeneous anisotropic aquifer conditions. In the present study methods were developed to analyse partially penetrating pumping tests and multi-level single-well dipole tests based on an inverse numerical model. The obtained horizontal hydraulic conductivities from the partially penetrating pumping tests were in accordance with measurements obtained from multi-level slug tests and mini slug tests. Accordance was also achieved between the anisotropy ratios determined from partially penetrating pumping tests and multi-level single-well dipole tests. It was demonstrated that the partially penetrating pumping test analysed by and inverse numerical model is a very valuable technique that may provide hydraulic information on the storage terms and the vertical distribution of the horizontal and vertical hydraulic conductivity under both confined and unconfined aquifer conditions. (EG) 138 refs.

  14. Two phase flow arising in hydraulics

    Czech Academy of Sciences Publication Activity Database

    Straškraba, Ivan

    2015-01-01

    Roč. 60, č. 1 (2015), s. 21-33 ISSN 0862-7940 R&D Projects: GA ČR GA201/08/0012 Institutional support: RVO:67985840 Keywords : compressible fluid * Navier-Stokes equations * hydraulic systems Subject RIV: BA - General Mathematics Impact factor: 0.507, year: 2015 http://link.springer.com/article/10.1007/s10492-015-0083-9

  15. Hydraulic oil control system for transformer stations

    International Nuclear Information System (INIS)

    Truong, P.

    2002-01-01

    'Full text:' Electrical oil control systems are commonly used to contain large volumes of spilled oil in transformer stations. Specially calibrated floats, some of which are designed to float only in oil and others only in water, are used in combination with a pump to contain oil at the catch basin below a transformer station.This electrical control system requires frequent maintenance and inspections to ensure the electrical system is not affected by any electrical surges. Also the floats need to be inspected and cleaned frequently to prevent oil or grit build up that may affect the systems' ability to contain oil.Recognizing the limitations of electrical oil control systems, Hydro One is investigating alternative control systems. A hydraulic oil control system is being investigated as an alternative which can backup oil in a containment area while allowing any water entering the containment area to pass through. Figure 1 shows a schematic of a bench-top model tested at Ryerson University. Oil and water separation occurs within the double-piped column. Oil and water are allowed to enter the external pipe column but only water is allowed to exit the internal pipe column. The internal pipe column is designed to generate enough hydrostatic pressure to ensure the oil is contained in the external pipe column.The hydraulic oil control system provides a reliable control mechanism and requires less maintenance compared to that of the electrical control system. Since the hydraulic oil control system has no moving parts, nor would any parts that require electricity, it is not affected by electrical surges such as lightening.The maintenance requirements of the hydraulic oil control system are: the removal of any oil and grit from the catch basin, and the occasional visual inspection for any crack or clogs in the system. (author)

  16. In-place testing of hydraulic snubbers

    International Nuclear Information System (INIS)

    Raymont, J.M. Jr.

    1986-01-01

    Over the last few years, an increasing number of utilities have implemented periodic in-service inspection (ISI) programs of their hydraulic snubbers. This thrust has caused the nuclear power industry to seek cost-effective means of testing hydraulic snubbers. This paper reviews the following aspects of in-place testing and develops a technical justification for its use as a viable alternative to test bench testing. (1) A detailed examination of how in-place testing works is provided. Discussed are the hydraulic principles, fluid flow paths, and snubber test setup. (2) A comparison of the test bench and in-place test machines is provided. The discussion reviews the similarities and differences between the two test methods as well as the test results. (3) The need for correlation of in-place test results back to test bench data with a snubber footprint is discussed. (4) The issue of partial load testing with extrapolation to full load testing is discussed and compared with full load testing. The hydraulic principles as well as the costs and benefits of partial load versus full load testing are compared. (5) In-place test machine technology is reviewed. The operating principles, accuracies, and limitations are presented. (6) Actual test data are provided and reviewed on a test-by-test basis. (7) Lessons learned from actual in-place test jobs are reviewed. (8) In-place test procedures and calibration practices are outlined to illustrate the nature of the required planning on the part of the utility

  17. Thermal-Hydraulic Experiment Facility (THEF)

    International Nuclear Information System (INIS)

    Martinell, J.S.

    1982-01-01

    This paper provides an overview of the Thermal-Hydraulic Experiment Facility (THEF) at the Idaho National Engineering Laboratory (INEL). The overview describes the major test systems, measurements, and data acquisition system, and presents objectives, facility configuration, and results for major experimental projects recently conducted at the THEF. Plans for future projects are also discussed. The THEF is located in the Water Reactor Research Test Facility (WRRTF) area at the INEL

  18. Hydraulic upright of a mine support

    Energy Technology Data Exchange (ETDEWEB)

    Solomakhin, A N; Il' in, V A; Ponomarenko, Yu F; Shakhmeyster, Yu L

    1979-04-30

    The hydraulic upright of a mine support, which includes a housing, piston with compacting element and dirt collector, rod and guide sleeve, is described. In order to improve protection of the piston element from abrasive particles and to reduce the pressure differential the piston of the upright is also equipped with a compaction ring, whose lateral surface has a groove beneath the compacting element. The surface on the side of the working fluid supply is made conical in order to remove dirt.

  19. Hydraulic Aspects of Vegetation Maintanence in Streams

    DEFF Research Database (Denmark)

    Larsen, Torben; Vestergaard, Kristian

    1991-01-01

    This paper describes the importance of the underwater vegetation on Danish streams and some of the consequences of vegetation maintenance. the influence of the weed on the hydraulic conditions is studied through experiments in a smaller stream and the effect of cutting channels through the weed...... is measured. A method for predicting the Manning's n as a function of the discharge conditions is suggested, and also a working hypothesis for predictions of the effect of channel cutting is presented....

  20. Thermal-hydraulics of actinide burner reactors

    International Nuclear Information System (INIS)

    Takizuka, Takakazu; Mukaiyama, Takehiko; Takano, Hideki; Ogawa, Toru; Osakabe, Masahiro.

    1989-07-01

    As a part of conceptual study of actinide burner reactors, core thermal-hydraulic analyses were conducted for two types of reactor concepts, namely (1) sodium-cooled actinide alloy fuel reactor, and (2) helium-cooled particle-bed reactor, to examine the feasibility of high power-density cores for efficient transmutation of actinides within the maximum allowable temperature limits of fuel and cladding. In addition, calculations were made on cooling of actinide fuel assembly. (author)

  1. Legal aspects of the hydraulic fracturing method

    Directory of Open Access Journals (Sweden)

    Marta Duraj

    2011-12-01

    Full Text Available In recent months the possibility of extracting shale gas by way of the hydraulic fracturing method in Poland as well as across EU territory has been widely discussed. The European Parliament is to decide whether to ban this method. There are various legal, ecological and economical aspects influencing European legislators. It is hard not to notice how strongly the anti- and pro- hydraulic fracturing lobbies are connected with business. At the moment there are no specific regulations that relate directly to this extraction method, neither in the EU as a whole nor in Poland. However, in Poland a new Geological and Mining Act is supposed to come into force on 1st January 2012, which will regulate natural gas extraction with a view to ensure proper extraction of shale gas in the near future. This article is aimed at showing Polish regulations, both planned and currently in force, as well as the relevant EU law in respect of shale gas extraction. The author would like to emphasize the need to create one coherent legislative regime which would enable entrepreneurs to commence extraction by way of hydraulic fracturing without creating a danger for the environment.

  2. Scaling the viscous circular hydraulic jump

    Science.gov (United States)

    Argentina, Mederic; Cerda, Enrique; Duchesne, Alexis; Limat, Laurent

    2017-11-01

    The formation mechanism of hydraulic jumps has been proposed by Belanger in 1828 and rationalised by Lord Rayleigh in 1914. As the Froude number becomes higher than one, the flow super criticality induces an instability which yields the emergence of a steep structure at the fluid surface. Strongly deformed liquid-air interface can be observed as a jet of viscous fluid impinges a flat boundary at high enough velocity. In this experimental setup, the location of the jump depends on the viscosity of the liquid, as shown by T. Bohr et al. in 1997. In 2014, A. Duchesne et al. have established the constancy of the Froude number at jump. Hence, it remains a contradiction, in which the radial hydraulic jump location might be explained through inviscid theory, but is also viscosity dependent. We present a model based on the 2011 Rojas et al. PRL, which solves this paradox. The agreement with experimental measurements is excellent not only for the prediction of the position of the hydraulic jump, but also for the determination of the fluid thickness profile. We predict theoretically the critical value of the Froude number, which matches perfectly to that measured by Duchesne et al. We acknowledge the support of the CNRS and the Universit Cte d'Azur, through the IDEX funding.

  3. Hydraulic system for driving control rods

    International Nuclear Information System (INIS)

    Okuzumi, Naoaki.

    1982-01-01

    Purpose: To enable safety reactor shut down upon occurrence of an abnormal excess pressure in a hydraulic control unit. Constitution: The actuation pressure for a pressure switch that generates a scram signal is set lower than the release pressure set to a pressure release valve. Thus, if the pressure of nitrogen gas in a nitrogen container increases such as upon exposure of the hydraulic control unit to a high temperature, the pressure switch is actuated at first to generate the scram signal and a scram valve is opened to supply water at high pressure to control rod drives under the driving force of the nitrogen gas at high pressure to rapidly insert the control element into the reactor and shut down it. If the pressure of the nitrogen gas still increases after the scram, the pressure release valve is opened to release the nitrogen gas at high temperature to the atmosphere. Since the scram is attained before the actuation of the pressure release valve, safety reactor shut down can be attained and the hydraulic control unit can be protected. (Sekiya, K.)

  4. Technology and control for hydraulic manipulators

    International Nuclear Information System (INIS)

    Measson, Y.; David, O.; Louveau, F.; Friconneau, J.P.

    2003-01-01

    Hydraulic manipulators are candidate for fusion reactor maintenance. Their main advantages are their large payload with respect to volume and mass, their reliability and their robustness. However, due to their force control limitations, they are disqualified for precise manipulation and are dangerous for the environment and themselves in case of unexpected collision. CEA, in collaboration with CYBERNETIX and IFREMER has developed the advanced hydraulic robot MAESTRO. Force and hybrid control has been developed in order to avoid the previous problems. Using 'pressure' control servo-valve instead of the standard 'flow' control servo-valve (standard configuration of the MAESTRO) makes a real simplification of the control loop. No more pressure sensors are needed for monitoring the hydraulic joint in force control mode and using this kind of valves makes big safety improvements. The French company IN-LHC, designed and manufactured a prototype of servo-valve that fits the performances and space constraints of the Maestro arm. A characterisation of this new product was made on a mock-up and a set of these prototypes integrated in the Maestro slave-arm. A comparison between the two actuating technologies was made and showed that the performances of the pressure servo-valves make it applicable to general application

  5. Improving the support characteristics of hydraulic fill

    Energy Technology Data Exchange (ETDEWEB)

    Corson, D. R.; Dorman, K. R.; Sprute, R. H.

    1980-05-15

    Extensive laboratory and field testing has defined the physical properties of hydraulic fill. Effect of void ratio on percolation rate has been quantified, and tests were developed to estimate waterflow through fill material in a given state underground. Beneficial effect on fill's support capability through addition of cement alone or in conjunction with vibratory compaction has been investigated. Two separate field studies in operating cut-and-fill mines measured vein-wall deformation and loads imposed on backfilled stopes. Technology has been developed that will effectively and efficiently dewater and densify ultra-fine-grained slurries typical of metal mine hydraulic backfill. At least two operators are using this electrokinetic technique to dewater slimes collected in underground sumps or impoundments. This technique opens up the possibility of using the total unclassified tailings product as a hydraulic backfill. Theoretical enhancement of ground support and rock-burst control through improved support capability will be tested in a full-scale mine stope installation. Both a horizontal layer and a vertical column of high modulus fill will be placed in an attempt to reduce stope wall closure, support more ground pressure, and lessen rock-burst occurrence.

  6. A Low-Cost Automated Test Column to Estimate Soil Hydraulic Characteristics in Unsaturated Porous Media

    Directory of Open Access Journals (Sweden)

    J. Salas-García

    2017-01-01

    Full Text Available The estimation of soil hydraulic properties in the vadose zone has some issues, such as accuracy, acquisition time, and cost. In this study, an inexpensive automated test column (ATC was developed to characterize water flow in a homogeneous unsaturated porous medium by the simultaneous estimation of three hydraulic state variables: water content, matric potential, and water flow rates. The ATC includes five electrical resistance probes, two minitensiometers, and a drop counter, which were tested with infiltration tests using the Hydrus-1D model. The results show that calibrations of electrical resistance probes reasonably match with similar studies, and the maximum error of calibration of the tensiometers was 4.6% with respect to the full range. Data measured by the drop counter installed in the ATC exhibited a high consistency with the electrical resistance probes, which provides an independent verification of the model and indicates an evaluation of the water mass balance. The study results show good performance of the model against the infiltration tests, which suggests a robustness of the methodology developed in this study. An extension to the applicability of this system could be successfully used in low-budget projects in large-scale field experiments, which may be correlated with resistivity changes.

  7. Porosity and hydraulic conductivity estimation of the basaltic aquifer in Southern Syria by using nuclear and electrical well logging techniques

    Science.gov (United States)

    Asfahani, Jamal

    2017-08-01

    An alternative approach using nuclear neutron-porosity and electrical resistivity well logging of long (64 inch) and short (16 inch) normal techniques is proposed to estimate the porosity and the hydraulic conductivity ( K) of the basaltic aquifers in Southern Syria. This method is applied on the available logs of Kodana well in Southern Syria. It has been found that the obtained K value by applying this technique seems to be reasonable and comparable with the hydraulic conductivity value of 3.09 m/day obtained by the pumping test carried out at Kodana well. The proposed alternative well logging methodology seems as promising and could be practiced in the basaltic environments for the estimation of hydraulic conductivity parameter. However, more detailed researches are still required to make this proposed technique very performed in basaltic environments.

  8. Determining the Conditions for the Hydraulic Impacts Emergence at Hydraulic Systems

    Directory of Open Access Journals (Sweden)

    Mazurenko A.S.

    2017-08-01

    Full Text Available This research aim is to develop a method for modeling the conditions for the critical hydrau-lic impacts emergence on thermal and nuclear power plants’ pipeline systems pressure pumps depart-ing from the general provisions of the heat and hydrodynamic instability theory. On the developed method basis, the conditions giving rise to the reliability-critical hydraulic impacts emergence on pumps for the thermal and nuclear power plants’ typical pipeline system have been determined. With the flow characteristic minimum allowable (critical sensitivity, the flow velocity fluctuations ampli-tude reaches critical values at which the pumps working elements’ failure occurs. The critical hydrau-lic impacts emergence corresponds to the transition of the vibrational heat-hydrodynamic instability into an aperiodic one. As research revealed, a highly promising approach as to the preventing the criti-cal hydraulic impacts related to the foreground use of pumps having the most sensitive consumption (at supply network performance (while other technical characteristics corresponding to that parame-ter. The research novelty refers to the suggested method elaborated by the authors’ team, which, in contrast to traditional approaches, is efficient in determining the pump hydraulic impact occurrence conditions when the vibrational heat-hydrodynamic instability transition to the aperiodic instability.

  9. Rapid hydraulic recovery in Eucalyptus pauciflora after drought: linkages between stem hydraulics and leaf gas exchange.

    Science.gov (United States)

    Martorell, Sebastià; Diaz-Espejo, Antonio; Medrano, Hipólito; Ball, Marilyn C; Choat, Brendan

    2014-03-01

    In woody plants, photosynthetic capacity is closely linked to rates at which the plant hydraulic system can supply water to the leaf surface. Drought-induced embolism can cause sharp declines in xylem hydraulic conductivity that coincide with stomatal closure and reduced photosynthesis. Recovery of photosynthetic capacity after drought is dependent on restored xylem function, although few data exist to elucidate this coordination. We examined the dynamics of leaf gas exchange and xylem function in Eucalyptus pauciflora seedlings exposed to a cycle of severe water stress and recovery after re-watering. Stomatal closure and leaf turgor loss occurred at water potentials that delayed the extensive spread of embolism through the stem xylem. Stem hydraulic conductance recovered to control levels within 6 h after re-watering despite a severe drought treatment, suggesting an active mechanism embolism repair. However, stomatal conductance did not recover after 10 d of re-watering, effecting tighter control of transpiration post drought. The dynamics of recovery suggest that a combination of hydraulic and non-hydraulic factors influenced stomatal behaviour post drought. © 2013 John Wiley & Sons Ltd.

  10. Joint inversion of hydraulic head and self-potential data associated with harmonic pumping tests

    Science.gov (United States)

    Soueid Ahmed, A.; Jardani, A.; Revil, A.; Dupont, J. P.

    2016-09-01

    Harmonic pumping tests consist in stimulating an aquifer by the means of hydraulic stimulations at some discrete frequencies. The inverse problem consisting in retrieving the hydraulic properties is inherently ill posed and is usually underdetermined when considering the number of well head data available in field conditions. To better constrain this inverse problem, we add self-potential data recorded at the ground surface to the head data. The self-potential method is a passive geophysical method. Its signals are generated by the groundwater flow through an electrokinetic coupling. We showed using a 3-D saturated unconfined synthetic aquifer that the self-potential method significantly improves the results of the harmonic hydraulic tomography. The hydroelectric forward problem is obtained by solving first the Richards equation, describing the groundwater flow, and then using the result in an electrical Poisson equation describing the self-potential problem. The joint inversion problem is solved using a reduction model based on the principal component geostatistical approach. In this method, the large prior covariance matrix is truncated and replaced by its low-rank approximation, allowing thus for notable computational time and storage savings. Three test cases are studied, to assess the validity of our approach. In the first test, we show that when the number of harmonic stimulations is low, combining the harmonic hydraulic and self-potential data does not improve the inversion results. In the second test where enough harmonic stimulations are performed, a significant improvement of the hydraulic parameters is observed. In the last synthetic test, we show that the electrical conductivity field required to invert the self-potential data can be determined with enough accuracy using an electrical resistivity tomography survey using the same electrodes configuration as used for the self-potential investigation.

  11. Vulnerability to cavitation, hydraulic efficiency, growth and survival in an insular pine (Pinus canariensis).

    Science.gov (United States)

    López, Rosana; López de Heredia, Unai; Collada, Carmen; Cano, Francisco Javier; Emerson, Brent C; Cochard, Hervé; Gil, Luis

    2013-06-01

    It is widely accepted that hydraulic failure due to xylem embolism is a key factor contributing to drought-induced mortality in trees. In the present study, an attempt is made to disentangle phenotypic plasticity from genetic variation in hydraulic traits across the entire distribution area of a tree species to detect adaptation to local environments. A series of traits related to hydraulics (vulnerability to cavitation and hydraulic conductivity in branches), growth performance and leaf mass per area were assessed in eight Pinus canariensis populations growing in two common gardens under contrasting environments. In addition, the neutral genetic variability (FST) and the genetic differentiation of phenotypic variation (QST) were compared in order to identify the evolutionary forces acting on these traits. The variability for hydraulic traits was largely due to phenotypic plasticity. Nevertheless, the vulnerability to cavitation displayed a significant genetic variability (approx. 5 % of the explained variation), and a significant genetic × environment interaction (between 5 and 19 % of the explained variation). The strong correlation between vulnerability to cavitation and survival in the xeric common garden (r = -0·81; P < 0·05) suggests a role for the former in the adaptation to xeric environments. Populations from drier sites and higher temperature seasonality were less vulnerable to cavitation than those growing at mesic sites. No trade-off between xylem safety and efficiency was detected. QST of parameters of the vulnerability curve (0·365 for P50 and the slope of the vulnerability curve and 0·452 for P88) differed substantially from FST (0·091), indicating divergent selection. In contrast, genetic drift alone was found to be sufficient to explain patterns of differentiation for xylem efficiency and growth. The ability of P. canariensis to inhabit a wide range of ecosystems seemed to be associated with high phenotypic plasticity and some degree of local

  12. Intraspecific Variation in Wood Anatomical, Hydraulic, and Foliar Traits in Ten European Beech Provenances Differing in Growth Yield

    Science.gov (United States)

    Hajek, Peter; Kurjak, Daniel; von Wühlisch, Georg; Delzon, Sylvain; Schuldt, Bernhard

    2016-01-01

    In angiosperms, many studies have described the inter-specific variability of hydraulic-related traits and little is known at the intra-specific level. This information is however mandatory to assess the adaptive capacities of tree populations in the context of increasing drought frequency and severity. Ten 20-year old European beech (Fagus sylvatica L.) provenances representing the entire distribution range throughout Europe and differing significantly in aboveground biomass increment (ABI) by a factor of up to four were investigated for branch wood anatomical, hydraulic, and foliar traits in a provenance trial located in Northern Europe. We quantified to which extend xylem hydraulic and leaf traits are under genetic control and tested whether the xylem hydraulic properties (hydraulic efficiency and safety) trades off with yield and wood anatomical and leaf traits. Our results showed that only three out of 22 investigated ecophysiological traits showed significant genetic differentiations between provenances, namely vessel density (VD), the xylem pressure causing 88% loss of hydraulic conductance and mean leaf size. Depending of the ecophysiological traits measured, genetic differentiation between populations explained 0–14% of total phenotypic variation, while intra-population variability was higher than inter-population variability. Most wood anatomical traits and some foliar traits were additionally related to the climate of provenance origin. The lumen to sapwood area ratio, vessel diameter, theoretical specific conductivity and theoretical leaf-specific conductivity as well as the C:N-ratio increased with climatic aridity at the place of origin while the carbon isotope signature (δ13C) decreased. Contrary to our assumption, none of the wood anatomical traits were related to embolism resistance but were strong determinants of hydraulic efficiency. Although ABI was associated with both VD and δ13C, both hydraulic efficiency and embolism resistance were

  13. A low cost apparatus for measuring the xylem hydraulic conductance in plants

    Directory of Open Access Journals (Sweden)

    Luciano Pereira

    2012-01-01

    Full Text Available Plant yield and resistance to drought are directly related to the efficiency of the xylem hydraulic conductance and the ability of this system to avoid interrupting the flow of water. In this paper we described in detail the assembling of an apparatus proposed by TYREE et al. (2002, and its calibration, as well as low cost adaptations that make the equipment accessible for everyone working in this research area. The apparatus allows measuring the conductance in parts of roots or shoots (root ramifications or branches, or in the whole system, in the case of small plants or seedlings. The apparatus can also be used to measure the reduction of conductance by embolism of the xylem vessels. Data on the hydraulic conductance of eucalyptus seedlings obtained here and other reports in the literature confirm the applicability of the apparatus in physiological studies on the relationship between productivity and water stress.

  14. MATHEMATICAL MODELING OF WORKING PROCESS IN HYDRAULIC DRIVE OF SPECIFICALLY HEAVY-DUTY TRUCK STEERING

    Directory of Open Access Journals (Sweden)

    E. M. Zabolotsky

    2006-01-01

    Full Text Available The paper provides an analysis that shows application of pump-controlled steering hydraulic drives. Dynamic model of steering hydraulic drive of open-cast BelAZ-75131 dump truck developed at BNTU and also mathematical models for circuit consisting of a metering pump and a turning cylinder and a flow amplifier and a turning cylinder with due account of compressibility and resistance of service drain line. It is noted that on the basis of the given methodology a multi-variant dynamic calculation has been carried out, drive dynamics has been analyzed at various design and component parameters of a metering pump and a flow amplifier, rational values of these parameters has been selected for design development. The paper also gives an algorithm scheme for the solution of the derived equation systems.

  15. Numerical calculation for flow field of servo-tube guided hydraulic control rod driving system

    International Nuclear Information System (INIS)

    He Keyu; Han Weishi

    2010-01-01

    A new-style hydraulic control rod driving mechanism was put forward by using servo-tube control elements for the design of control rod driving mechanism. The results of numerical simulation by CFD program Fluent for flow field of hydraulic driving cylinder indicate that the bigger the outer diameter of servo-tube, the smaller the resistance coefficient of variable throttle orifice. The zero position gap of variable throttle orifice could be determined on 0.2 mm in the design. The pressure difference between the upper and nether surfaces of piston was mainly created by the throttle function of fixed throttle orifice. It can be effectively controlled by changing the gap of variable throttle orifice. And the lift force of driving cylinder is able to meet the requirement on the design load. (authors)

  16. Effect of the microstructure of mortars with low hydraulicity slag on their behavior in aggressive environments

    Directory of Open Access Journals (Sweden)

    Ahmed Hadj sadok

    2018-01-01

    Full Text Available Slag is one of the most used cement additives. Due to its latent hydraulic nature, attached to its hydraulicity, it can contribute to a microstructural modification and an improvement of the durability of the concrete face of aggressive environments. In this study, a low active slag is used in the manufacture of mortars as a substitute for cement, at a maximum rate of 50%. Firstly, a study of the microstructure with mercury porosimetry was used for determination of microstructural parameters (porosity, diameters and volume distribution. The behavior of mortars in aggressive environments (sodium and magnesium sulphate and seawater was studied later. Despite the low reactivity of studied slag, its presence especially at 50% rate, in the long term, has led to a refinement of the microstructure. This effect, among others, led to better resistivity of the mortars in the sulphate environnements.

  17. Hydraulic Apparatus for Mechanical Testing of Nuts

    Science.gov (United States)

    Hinkel, Todd J.; Dean, Richard J.; Hacker, Scott C.; Harrington, Douglas W.; Salazar, Frank

    2004-01-01

    The figure depicts an apparatus for mechanical testing of nuts. In the original application for which the apparatus was developed, the nuts are of a frangible type designed for use with pyrotechnic devices in spacecraft applications in which there are requirements for rapid, one-time separations of structures that are bolted together. The apparatus can also be used to test nonfrangible nuts engaged without pyrotechnic devices. This apparatus was developed to replace prior testing systems that were extremely heavy and immobile and characterized by long setup times (of the order of an hour for each nut to be tested). This apparatus is mobile, and the setup for each test can now be completed in about five minutes. The apparatus can load a nut under test with a static axial force of as much as 6.8 x 10(exp 5) lb (3.0 MN) and a static moment of as much as 8.5 x 10(exp 4) lb in. (9.6 x 10(exp 3) N(raised dot)m) for a predetermined amount of time. In the case of a test of a frangible nut, the pyrotechnic devices can be exploded to break the nut while the load is applied, in which case the breakage of the nut relieves the load. The apparatus can be operated remotely for safety during an explosive test. The load-generating portion of the apparatus is driven by low-pressure compressed air; the remainder of the apparatus is driven by 110-Vac electricity. From its source, the compressed air is fed to the apparatus through a regulator and a manually operated valve. The regulated compressed air is fed to a pneumatically driven hydraulic pump, which pressurizes oil in a hydraulic cylinder, thereby causing a load to be applied via a hydraulic nut (not to be confused with the nut under test). During operation, the hydraulic pressure is correlated with the applied axial load, which is verified by use of a load cell. Prior to operation, one end of a test stud (which could be an ordinary threaded rod or bolt) is installed in the hydraulic nut. The other end of the test stud passes

  18. Fluid Temperature of Aero Hydraulic Systems

    Directory of Open Access Journals (Sweden)

    I. S. Shumilov

    2016-01-01

    Full Text Available In modern supersonic aircrafts due to aerodynamic skin heating a temperature of hydraulics environment significantly exceeds that of permissible for fluids used. The same problem exists for subsonic passenger aircrafts, especially for Airbuses, which have hydraulics of high power where convective heat transfer with the environment is insufficient and there is no required temperature control of fluid. The most significant in terms of heat flow is the flow caused by the loss of power to the pump and when designing the hydraulic system (HS it is necessary to pay very serious attention to it. To use a constant capacity pump is absolutely unacceptable, since HS efficiency in this case is extremely low, and the most appropriate are variable-capacity pumps, cut-off pumps, dual-mode pumps. The HS fluid cooling system should provide high reliability, lightweight, simple design, and a specified heat transfer in all flight modes.A system cooling the fluid by the fuel of feeding lines of the aircraft engines is the most effective, and it is widely used in supersonic aircrafts, where power of cooling system is essential. Subsonic aircrafts widely use convective heat exchangers. In thermal design of the aircraft hydraulics, the focus is generally given to the maximum and minimum temperatures of the HS fluid, the choice of the type of heat exchanger (convective or flow-through, the place of its installation. In calculating the operating temperature of a hydraulic system and its cooling systems it is necessary to determine an increase of the working fluid temperature when throttling it. There are three possible formulas to calculate the fluid temperature in throttling, with the error of a calculated temperature drop from 30% to 4%.The article considers the HS stationary and noon-stationary operating conditions and their calculation, defines temperatures of fluid and methods to control its specified temperature. It also discusses various heat exchanger schemes

  19. Acquisition and clearance of multidrug resistant Acinetobacter baumannii on healthy young adults concurrently burned in a dust explosion in Taiwan: the implication for antimicrobial stewardship.

    Science.gov (United States)

    Huang, Po-Yen; Shie, Shian-Sen; Ye, Jung-Jr; Lin, Shih-Pin; Liu, Tsui-Ping; Wu, Ting-Shu; Wu, Tsu-Lan; Chuang, Shiow-Shuh; Cheng, Ming-Huei; Hsieh, Yu-Chia; Huang, Ching-Tai

    2017-08-30

    Information is limited about the effect of restricted carbapenem use on clearance of multi-drug resistant Acinetobacter baumannii (MDRAB). We sought to determine the time effect of antibiotic exposure on multi-drug resistant Acinetobacter baumannii (MDRAB) acquisition and clearance. We conducted a retrospective observational study at the intensive care units of a tertiary medical center. Forty-two of a cohort of previously healthy young adults who were concurrently burned by a dust explosion was included. Cases consisted of those from whom MDRAB was isolated during hospitalization. Controls consisted of patients from whom MDRAB was not isolated in the same period. Use of antimicrobial agents was compared based on days of therapy per 1,000 patient-days (DOT/1,000PD). A 2-state Markov multi-state model was used to estimate the risk of acquisition and clearance of MDRAB. MDRAB was discovered in 9/42 (21.4%) individuals. The cases had significantly higher use of carbapenem (652 DOT/1,000PD vs. 385 DOT/1,000PD, P < 0.001) before MDRAB isolation. For the cases, clearance of MDRAB was associated with lower use of carbapenem (469 DOT/1,000PD vs. 708 DOT/1,000PD, P = 0.003) and higher use of non-carbapenem beta-lactam (612 DOT/1,000PD vs. 246 DOT/1,000PD, P <0.001). In multi-state model, each additional DOT of carbapenem increased the hazard of acquiring MDRAB (hazard ratio (HR), 1.08; 95% confidence interval (CI) 1.01-1.16) and each additional DOT of non-carbapenem beta-lactam increased the protection of clearing MDRAB (HR, 1.25; 95% CI 1.07-1.46). Both acquisition and clearance of MDRAB were related to antibiotic exposure in a homogeneous population. Our findings suggest that early discontinuation of carbapenem could be an effective measure in antibiotic stewardship for the control of MDRAB spreading.

  20. Linking Tropical Forest Function to Hydraulic Traits in a Size-Structured and Trait-Based Model

    Science.gov (United States)

    Christoffersen, B. O.; Gloor, M.; Fauset, S.; Fyllas, N.; Galbraith, D.; Baker, T. R.; Rowland, L.; Fisher, R.; Binks, O.; Sevanto, S.; Xu, C.; Jansen, S.; Choat, B.; Mencuccini, M.; McDowell, N. G.; Meir, P.

    2015-12-01

    A major weakness of forest ecosystem models is their inability to capture the diversity of responses to changes in water availability, severely hampering efforts to predict the fate of tropical forests under climate change. Such models often prescribe moisture sensitivity using heuristic response functions that are uniform across all individuals and lack important knowledge about trade-offs in hydraulic traits. We address this weakness by implementing a process representation of plant hydraulics into an individual- and trait-based model (Trait Forest Simulator; TFS) intended for application at discrete sites where community-level distributions of stem and leaf trait spectra (wood density, leaf mass per area, leaf nitrogen and phosphorus content) are known. The model represents a trade-off in the safety and efficiency of water conduction in xylem tissue through hydraulic traits, while accounting for the counteracting effects of increasing hydraulic path length and xylem conduit taper on whole-plant hydraulic resistance with increasing tree size. Using existing trait databases and additional meta-analyses from the rich literature on tropical tree ecophysiology, we obtained all necessary hydraulic parameters associated with xylem conductivity, vulnerability curves, pressure-volume curves, and hydraulic architecture (e.g., leaf-to-sapwood area ratios) as a function of the aforementioned traits and tree size. Incorporating these relationships in the model greatly improved the diversity of tree response to seasonal changes in water availability as well as in response to drought, as determined by comparison with field observations and experiments. Importantly, this individual- and trait-based framework provides a testbed for identifying both critical processes and functional traits needed for inclusion in coarse-scale Dynamic Global Vegetation Models, which will lead to reduced uncertainty in the future state of tropical forests.