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Sample records for hydraulic feedback loop

  1. Feedback Loop Gains and Feedback Behavior (1996)

    DEFF Research Database (Denmark)

    Kampmann, Christian Erik

    2012-01-01

    Linking feedback loops and system behavior is part of the foundation of system dynamics, yet the lack of formal tools has so far prevented a systematic application of the concept, except for very simple systems. Having such tools at their disposal would be a great help to analysts in understanding...... large, complicated simulation models. The paper applies tools from graph theory formally linking individual feedback loop strengths to the system eigenvalues. The significance of a link or a loop gain and an eigenvalue can be expressed in the eigenvalue elasticity, i.e., the relative change...... of an eigenvalue resulting from a relative change in the gain. The elasticities of individual links and loops may be found through simple matrix operations on the linearized system. Even though the number of feedback loops can grow rapidly with system size, reaching astronomical proportions even for modest systems...

  2. Hydraulic loop: practices using open control systems

    International Nuclear Information System (INIS)

    Carrasco, J.A.; Alonso, L.; Sanchez, F.

    1998-01-01

    The Tecnatom Hydraulic Loop is a dynamic training platform. It has been designed with the purpose of improving the work in teams. With this system, the student can obtain a full scope vision of a system. The hydraulic Loop is a part of the Tecnatom Maintenance Centre. The first objective of the hydraulic Loop is the instruction in components, process and process control using open control system. All the personal of an electric power plant can be trained in the Hydraulic Loop with specific courses. The development of a dynamic tool for tests previous to plant installations has been an additional objective of the Hydraulic Loop. The use of this platform is complementary to the use of full-scope simulators in order to debug and to analyse advanced control strategies. (Author)

  3. Feedback - closing the loop digitally

    International Nuclear Information System (INIS)

    Zagel, J.; Chase, B.

    1992-01-01

    Many feedback and feedforward systems are now using microprocessors within the loop. We describe the wide range of possibilities and problems that arise. We also propose some ideas for analysis and testing, including examples of motion control in the Flying Wire systems in Main Ring and Tevatron and Low Level RF control now being built for the Fermilab Linac upgrade. (author)

  4. Feedback loop compensates for rectifier nonlinearity

    Science.gov (United States)

    1966-01-01

    Signal processing circuit with two negative feedback loops rectifies two sinusoidal signals which are 180 degrees out of phase and produces a single full-wave rectified output signal. Each feedback loop incorporates a feedback rectifier to compensate for the nonlinearity of the circuit.

  5. FEEDBACK LINEARISATION APPLIED ON A HYDRAULIC

    DEFF Research Database (Denmark)

    Andersen, Torben Ole; Hansen, Michael Rygaard; Pedersen, Henrik C.

    2005-01-01

    is on developing and applying several different feedback linearisation (FL) controllers to the individual servo actuators in a hydraulically driven servo robot to evaluate and compare their possiblities and limitations. This is done based on both simulation and experimental results.......Generally most hydraulic systems are intrensically non-linear, why applying linear control techniques typically results in conservatively dimensioned controllers to obtain stable performance. Non-linear control techniques have the potential of overcoming these problems, and in this paper the focus...

  6. Mercury Thermal Hydraulic Loop (MTHL) Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Felde, David K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Crye, Jason Michael [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wendel, Mark W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Yoder, Jr, Graydon L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Farquharson, George [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jallouk, Philip A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McFee, Marshall T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pointer, William David [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ruggles, Art E. [Univ. of Tennessee, Knoxville, TN (United States); Carbajo, Juan J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-03-01

    The Spallation Neutron Source (SNS) is a high-power linear accelerator built at Oak Ridge National Laboratory (ORNL) which incorporates the use of a flowing liquid mercury target. The Mercury Thermal Hydraulic Loop (MTHL) was constructed to investigate and verify the heat transfer characteristics of liquid mercury in a rectangular channel. This report provides a compilation of previously reported results from the water-cooled and electrically heated straight and curved test sections that simulate the geometry of the window cooling channel in the target nose region.

  7. Gas Test Loop Booster Fuel Hydraulic Testing

    International Nuclear Information System (INIS)

    Gas Test Loop Hydraulic Testing Staff

    2006-01-01

    The Gas Test Loop (GTL) project is for the design of an adaptation to the Advanced Test Reactor (ATR) to create a fast-flux test space where fuels and materials for advanced reactor concepts can undergo irradiation testing. Incident to that design, it was found necessary to make use of special booster fuel to enhance the neutron flux in the reactor lobe in which the Gas Test Loop will be installed. Because the booster fuel is of a different composition and configuration from standard ATR fuel, it is necessary to qualify the booster fuel for use in the ATR. Part of that qualification is the determination that required thermal hydraulic criteria will be met under routine operation and under selected accident scenarios. The Hydraulic Testing task in the GTL project facilitates that determination by measuring flow coefficients (pressure drops) over various regions of the booster fuel over a range of primary coolant flow rates. A high-fidelity model of the NW lobe of the ATR with associated flow baffle, in-pile-tube, and below-core flow channels was designed, constructed and located in the Idaho State University Thermal Fluids Laboratory. A circulation loop was designed and constructed by the university to provide reactor-relevant water flow rates to the test system. Models of the four booster fuel elements required for GTL operation were fabricated from aluminum (no uranium or means of heating) and placed in the flow channel. One of these was instrumented with Pitot tubes to measure flow velocities in the channels between the three booster fuel plates and between the innermost and outermost plates and the side walls of the flow annulus. Flow coefficients in the range of 4 to 6.5 were determined from the measurements made for the upper and middle parts of the booster fuel elements. The flow coefficient for the lower end of the booster fuel and the sub-core flow channel was lower at 2.3

  8. Gas Test Loop Booster Fuel Hydraulic Testing

    Energy Technology Data Exchange (ETDEWEB)

    Gas Test Loop Hydraulic Testing Staff

    2006-09-01

    The Gas Test Loop (GTL) project is for the design of an adaptation to the Advanced Test Reactor (ATR) to create a fast-flux test space where fuels and materials for advanced reactor concepts can undergo irradiation testing. Incident to that design, it was found necessary to make use of special booster fuel to enhance the neutron flux in the reactor lobe in which the Gas Test Loop will be installed. Because the booster fuel is of a different composition and configuration from standard ATR fuel, it is necessary to qualify the booster fuel for use in the ATR. Part of that qualification is the determination that required thermal hydraulic criteria will be met under routine operation and under selected accident scenarios. The Hydraulic Testing task in the GTL project facilitates that determination by measuring flow coefficients (pressure drops) over various regions of the booster fuel over a range of primary coolant flow rates. A high-fidelity model of the NW lobe of the ATR with associated flow baffle, in-pile-tube, and below-core flow channels was designed, constructed and located in the Idaho State University Thermal Fluids Laboratory. A circulation loop was designed and constructed by the university to provide reactor-relevant water flow rates to the test system. Models of the four booster fuel elements required for GTL operation were fabricated from aluminum (no uranium or means of heating) and placed in the flow channel. One of these was instrumented with Pitot tubes to measure flow velocities in the channels between the three booster fuel plates and between the innermost and outermost plates and the side walls of the flow annulus. Flow coefficients in the range of 4 to 6.5 were determined from the measurements made for the upper and middle parts of the booster fuel elements. The flow coefficient for the lower end of the booster fuel and the sub-core flow channel was lower at 2.3.

  9. Extended Cognition: Feedback Loops and Coupled Systems

    Directory of Open Access Journals (Sweden)

    Olga Markic

    2017-12-01

    Full Text Available The article explores two waves of active externalism. I first introduce the distinction between passive and active externalism and analyse a proposal of active externalism based on the principle of parity proposed by Clark and Chalmers. There are two main obstacles, causal-constitution fallacy and cognitive bloat, that threaten the extended cognition hypothesis. The second wave of discussions based on the complementarity principle deals with cognitive systems with feedback loops between internal and external elements and is a more radical departure from functionalism and traditional thinking about cognition. I conclude with some remarks on potential ethical considerations of extended cognition.

  10. Virtual grasping: closed-loop force control using electrotactile feedback.

    Science.gov (United States)

    Jorgovanovic, Nikola; Dosen, Strahinja; Djozic, Damir J; Krajoski, Goran; Farina, Dario

    2014-01-01

    Closing the control loop by providing somatosensory feedback to the user of a prosthesis is a well-known, long standing challenge in the field of prosthetics. Various approaches have been investigated for feedback restoration, ranging from direct neural stimulation to noninvasive sensory substitution methods. Although there are many studies presenting closed-loop systems, only a few of them objectively evaluated the closed-loop performance, mostly using vibrotactile stimulation. Importantly, the conclusions about the utility of the feedback were partly contradictory. The goal of the current study was to systematically investigate the capability of human subjects to control grasping force in closed loop using electrotactile feedback. We have developed a realistic experimental setup for virtual grasping, which operated in real time, included a set of real life objects, as well as a graphical and dynamical model of the prosthesis. We have used the setup to test 10 healthy, able bodied subjects to investigate the role of training, feedback and feedforward control, robustness of the closed loop, and the ability of the human subjects to generalize the control to previously "unseen" objects. Overall, the outcomes of this study are very optimistic with regard to the benefits of feedback and reveal various, practically relevant, aspects of closed-loop control.

  11. Virtual Grasping: Closed-Loop Force Control Using Electrotactile Feedback

    Directory of Open Access Journals (Sweden)

    Nikola Jorgovanovic

    2014-01-01

    Full Text Available Closing the control loop by providing somatosensory feedback to the user of a prosthesis is a well-known, long standing challenge in the field of prosthetics. Various approaches have been investigated for feedback restoration, ranging from direct neural stimulation to noninvasive sensory substitution methods. Although there are many studies presenting closed-loop systems, only a few of them objectively evaluated the closed-loop performance, mostly using vibrotactile stimulation. Importantly, the conclusions about the utility of the feedback were partly contradictory. The goal of the current study was to systematically investigate the capability of human subjects to control grasping force in closed loop using electrotactile feedback. We have developed a realistic experimental setup for virtual grasping, which operated in real time, included a set of real life objects, as well as a graphical and dynamical model of the prosthesis. We have used the setup to test 10 healthy, able bodied subjects to investigate the role of training, feedback and feedforward control, robustness of the closed loop, and the ability of the human subjects to generalize the control to previously “unseen” objects. Overall, the outcomes of this study are very optimistic with regard to the benefits of feedback and reveal various, practically relevant, aspects of closed-loop control.

  12. Boosted PWM open loop control of hydraulic proportional valves

    International Nuclear Information System (INIS)

    Amirante, R.; Innone, A.; Catalano, L.A.

    2008-01-01

    This paper presents an innovative open loop control technique for direct single stage hydraulic proportional valves whose response rate is significantly higher than that obtained by standard open loop control techniques, even comparable to more costly commercial closed loop systems. Different from standard open loop techniques, which provide the coil with a constant current proportional to the target position, the control strategy proposed in this paper employs the peak and hold (P and H) technique, widely used in Diesel engine modern supply systems, to boost the duty cycle value of the pulse width modulation (PWM) signal for a short time, namely during the spool displacement, while maintaining a lower duty cycle for holding the spool in the required opening position. The developed 'boosted PWM' technique only requires a low cost microcontroller, such as a peripheral interface controller (PIC) equipped with a metal oxide semiconductor (MOS) power driver. The PWM parameters are calibrated as a function of the spool displacement so as to maximize the response rate without introducing overshoots: the collected data are stored in the PIC. Different valve opening procedures with step response have been compared to demonstrate the merits of the proposed boosted PWM technique. No overshoots have been registered. Moreover, the proposed method is characterized by a significantly higher response rate with respect to a standard open loop control, which approximately has the same cost. Similar experimental tests show that the proposed boosted PWM technique has a response rate even higher than that provided by the more costly commercial closed loop system mounted on the valve, and it produces no overshoots

  13. Boosted PWM open loop control of hydraulic proportional valves

    Energy Technology Data Exchange (ETDEWEB)

    Amirante, R.; Catalano, L.A. [Dipartimento di Ingegneria Meccanica e Gestionale, Politecnico di Bari, Via Re David 200, 70125 Bari (Italy); Innone, A. [Universita degli Studi di Foggia, via Napoli, 25 Foggia (Italy)

    2008-08-15

    This paper presents an innovative open loop control technique for direct single stage hydraulic proportional valves whose response rate is significantly higher than that obtained by standard open loop control techniques, even comparable to more costly commercial closed loop systems. Different from standard open loop techniques, which provide the coil with a constant current proportional to the target position, the control strategy proposed in this paper employs the peak and hold (P and H) technique, widely used in Diesel engine modern supply systems, to boost the duty cycle value of the pulse width modulation (PWM) signal for a short time, namely during the spool displacement, while maintaining a lower duty cycle for holding the spool in the required opening position. The developed 'boosted PWM' technique only requires a low cost microcontroller, such as a peripheral interface controller (PIC) equipped with a metal oxide semiconductor (MOS) power driver. The PWM parameters are calibrated as a function of the spool displacement so as to maximize the response rate without introducing overshoots: the collected data are stored in the PIC. Different valve opening procedures with step response have been compared to demonstrate the merits of the proposed boosted PWM technique. No overshoots have been registered. Moreover, the proposed method is characterized by a significantly higher response rate with respect to a standard open loop control, which approximately has the same cost. Similar experimental tests show that the proposed boosted PWM technique has a response rate even higher than that provided by the more costly commercial closed loop system mounted on the valve, and it produces no overshoots. (author)

  14. Two-component feedback loops and deformed mechanics

    International Nuclear Information System (INIS)

    Tourigny, David S.

    2015-01-01

    It is shown that a general two-component feedback loop can be viewed as a deformed Hamiltonian system. Some of the implications of using ideas from theoretical physics to study biological processes are discussed. - Highlights: • Two-component molecular feedback loops are viewed as q-deformed Hamiltonian systems. • Deformations are reversed using Jackson derivatives to take advantage of working in the Hamiltonian limit. • New results are derived for the particular examples considered. • General deformations are suggested to be associated with a broader class of biological processes

  15. Benefits of Subliminal Feedback Loops in Human-Computer Interaction

    OpenAIRE

    Walter Ritter

    2011-01-01

    A lot of efforts have been directed to enriching human-computer interaction to make the user experience more pleasing or efficient. In this paper, we briefly present work in the fields of subliminal perception and affective computing, before we outline a new approach to add analog communication channels to the human-computer interaction experience. In this approach, in addition to symbolic predefined mappings of input to output, a subliminal feedback loop is used that provides feedback in evo...

  16. The double-loop feedback for active learning with understanding

    DEFF Research Database (Denmark)

    Christensen, Hans Peter

    2004-01-01

    Learning is an active process, and in engineering education authentic projects is often used to activate the students and promote learning. However, it is not all activity that leads to deep learning; and in a rapid changing society deep understanding is necessary for life-long learning. Empirical...... findings at DTU question the direct link between high activity and a deep approach to learning. Active learning is important to obtain engineering competencies, but active learning requires more than activity. Feedback and reflection is crucial to the learning process, since new knowledge is built...... on the student’s existing understanding. A model for an active learning process with a double-loop feedback is suggested - the first loop gives the student experience through experimentation, the second conceptual understanding through reflection. Students often miss the second loop, so it is important...

  17. A transimpedance amplifier using a novel current mode feedback loop

    CERN Document Server

    Anghinolfi, Francis; Delagnes, E; Jarron, Pierre; Scharfetter, L H H

    1995-01-01

    We present a transimpedance amplifier stage based on a novel current mode feedback topology. This circuit employs NMOS and PMOS transistors exclusively and requires neither capacitor for stabilizing the transimpedance loop nor resistor for the transresistance feedback and transistor loading. This amplifier circuit is fully compatible with submicron digital CMOS processes. The active feedback network consists of two grounded-gate MOS devices which split the output current in both the feedback and output branches. The transresistance and the phase margin are adjustable through external DC signals. The measured rise time of the impulse response of the amplifier implemented in an industrial 0,7µm CMOS process is 18 ns for a transresistance of 180 k‡ and 30 ns for a transresistance of 560 k‡. The measured Equivalent Noise Charge (ENC) is 800 rms e¯ for an input capacitance of 20 pF with the transresistance adjusted to 560 k‡.

  18. No evidence for an elephant-termite feedback loop in Sand Forest, South Africa

    NARCIS (Netherlands)

    Lagendijk, D. D G; Davies, A. B.; Eggleton, P.; Slotow, R.

    2016-01-01

    Termites and mammalian herbivores might derive mutual benefit from each other through positive feedback loops, but empirical evidence is lacking. One suggested positive feedback loop is between termites and elephant, both ecosystem engineers. Termites, as decomposer organisms, contribute to nutrient

  19. Finding Positive Feedback Loops in Environmental Models: A Mathematical Investigation

    Science.gov (United States)

    Sheikholeslami, R.; Razavi, S.

    2016-12-01

    Dynamics of most earth and environmental systems are generally governed by interactions between several hydrological (e.g., soil moisture and precipitation), geological (e.g., and erosion), geochemical (e.g., nutrient loading), and atmospheric (e.g., temperature) processes which operate on a range of spatio-temporal scales. These interactions create numerous feedback mechanisms with complex behaviours, and their understanding and representation can vary depending on the scale in space and/or time at which the system is analyzed. One of the most crucial characteristics of such complex systems is the existence of positive feedback loops. The presence of positive feedbacks may increase complexity, accelerate change, or trigger multiple stable states in the underlying dynamical system. Furthermore, because of the inherent non-linearity, it is often very difficult to obtain a general idea of their complex dynamics. Feedback loops in environmental systems have been well recognized and qualitatively discussed. With a quantitative/mathematical view, in this presentation, we address the question of how the positive feedback loops can be identified/implemented in environmental models. We investigate the nature of different feedback mechanisms and dynamics of simple example case studies that underlie fundamental processes such as vegetation, precipitation and soil moisture. To do this, we apply the concept of "interaction graph" from mathematics which is built from the Jacobian matrix of the dynamical system. The Jacobian matrix contains information on how variations of one state variable depends on variations of other variables, and thus can be used to understand the dynamical possibilities of feedback mechanisms in the underlying system. Moreover, this study highlights that there are some situations where the existence of positive feedback loops can cause multiple stable states, and thereby regime shifts in environmental systems. Systems with multiple stable states are

  20. Stabilization of self-mode-locked quantum dash lasers by symmetric dual-loop optical feedback

    Science.gov (United States)

    Asghar, Haroon; Wei, Wei; Kumar, Pramod; Sooudi, Ehsan; McInerney, John. G.

    2018-02-01

    We report experimental studies of the influence of symmetric dual-loop optical feedback on the RF linewidth and timing jitter of self-mode-locked two-section quantum dash lasers emitting at 1550 nm. Various feedback schemes were investigated and optimum levels determined for narrowest RF linewidth and low timing jitter, for single-loop and symmetric dual-loop feedback. Two symmetric dual-loop configurations, with balanced and unbalanced feedback ratios, were studied. We demonstrate that unbalanced symmetric dual loop feedback, with the inner cavity resonant and fine delay tuning of the outer loop, gives narrowest RF linewidth and reduced timing jitter over a wide range of delay, unlike single and balanced symmetric dual-loop configurations. This configuration with feedback lengths 80 and 140 m narrows the RF linewidth by 4-67x and 10-100x, respectively, across the widest delay range, compared to free-running. For symmetric dual-loop feedback, the influence of different power split ratios through the feedback loops was determined. Our results show that symmetric dual-loop feedback is markedly more effective than single-loop feedback in reducing RF linewidth and timing jitter, and is much less sensitive to delay phase, making this technique ideal for applications where robustness and alignment tolerance are essential.

  1. A closed-loop analysis of the tubuloglomerular feedback mechanism

    DEFF Research Database (Denmark)

    Holstein-Rathlou, N H

    1991-01-01

    The tubuloglomerular feedback (TGF) mechanism is of importance in the regulation of glomerular filtration rate (GFR). A second mechanism of potential importance is the change in proximal pressure caused by a change, for example, in the rate of proximal fluid reabsorption. The quantitative contrib...... and the late proximal flow rate, with changes in the proximal pressure of lesser importance. Furthermore, under closed-loop conditions the operating point for the TGF mechanism is at or close to the point of maximal sensitivity....... nl/min in steps of 5 nl/min. The open-loop gain (OLG) was 3.1 (range 1.5-9.9, n = 13) at the unperturbed tubular flow rate, and decreased as the tubular flow rate was either increased or decreased. The proximal pressure increased by 0.21 +/- 0.03 mmHg per unit increase in late proximal flow rate (nl...

  2. Operating problem of low specific speed pumps operating in closed hydraulic loop

    International Nuclear Information System (INIS)

    Rajput, A.K.

    1979-01-01

    Results of the studies of pressure pulsations caused by the centrifugal pump driving a typical sodium test loop are presented. The method of characteristics has been used for solving the equations of unsteady fluid flow in closed hydraulic loops with various boundary points, important of which are pump, control valve and heater tank (acting hydraulically as surge tank). Mathematical and computational models used for calculations are described. (M.G.B.)

  3. Pulse energy control through dual loop electronic feedback

    CSIR Research Space (South Africa)

    Jacobs, Cobus

    2006-07-01

    Full Text Available University of Stellenbosch WWW.LASER-RESEARCH.CO.ZA University of Stellenbosch Pulse Energy Control Through Dual Loop Electronic Feedback Cobus Jacobs, Steven Kriel Christoph Bollig, Thomas Jones Cobus Jacobs et al. Overview head2righthead2right...What is Laser Pulse Energy Control? head2righthead2rightWhy do we need it? head2righthead2rightHow do we get it? head2righthead2rightSimulation head2righthead2rightExperimental Setup head2righthead2rightResults Cobus Jacobs et al. head2righthead2right...

  4. Coupling between feedback loops in autoregulatory networks affects bistability range, open-loop gain and switching times

    International Nuclear Information System (INIS)

    Tiwari, Abhinav; Igoshin, Oleg A

    2012-01-01

    Biochemical regulatory networks governing diverse cellular processes such as stress-response, differentiation and cell cycle often contain coupled feedback loops. We aim at understanding how features of feedback architecture, such as the number of loops, the sign of the loops and the type of their coupling, affect network dynamical performance. Specifically, we investigate how bistability range, maximum open-loop gain and switching times of a network with transcriptional positive feedback are affected by additive or multiplicative coupling with another positive- or negative-feedback loop. We show that a network's bistability range is positively correlated with its maximum open-loop gain and that both quantities depend on the sign of the feedback loops and the type of feedback coupling. Moreover, we find that the addition of positive feedback could decrease the bistability range if we control the basal level in the signal-response curves of the two systems. Furthermore, the addition of negative feedback has the capacity to increase the bistability range if its dissociation constant is much lower than that of the positive feedback. We also find that the addition of a positive feedback to a bistable network increases the robustness of its bistability range, whereas the addition of a negative feedback decreases it. Finally, we show that the switching time for a transition from a high to a low steady state increases with the effective fold change in gene regulation. In summary, we show that the effect of coupled feedback loops on the bistability range and switching times depends on the underlying mechanistic details. (paper)

  5. Thermal-hydraulic analyses for in-pile SCWR fuel qualification test loops and SCWR material loop

    Energy Technology Data Exchange (ETDEWEB)

    Vojacek, A.; Mazzini, G.; Zmitkova, J.; Ruzickova, M. [Research Centre Rez (Czech Republic)

    2014-07-01

    One of the R&D directions of Research Centre Rez is dedicated to the supercritical water-cooled reactor concept (SCWR). Among the developed experimental facilities and infrastructure in the framework of the SUSEN project (SUStainable ENergy) is construction and experimental operation of the supercritical water loop SCWL focusing on material tests. At the first phase, this SCWL loop is assembled and operated out-of-pile in the dedicated loop facilities hall. At this out-of-pile operation various operational conditions are tested and verified. After that, in the second phase, the SCWL loop will be situated in-pile, in the core of the research reactor LVR-15, operated at CVR. Furthermore, it is planned to carry out a test of a small scale fuel assembly within the SuperCritical Water Reactor Fuel Qualification Test (SCWR-FQT) loop, which is now being designed. This paper presents the results of the thermal-hydraulic analyses of SCWL loop out-of-pile operation using the RELAP5/MOD3.3. The thermal-hydraulic modeling and the performed analyses are focused on the SCWL loop model validation through a comparison of the calculation results with the experimental results obtained at various operation conditions. Further, the present paper focuses on the transient analyses for start-up and shut-down of the FQT loop, particularly to explore the ability of system codes ATHLET 3.0A to simulate the transient between subcritical conditions and supercritical conditions. (author)

  6. Closed loop kinesthetic feedback for postural control rehabilitation.

    Science.gov (United States)

    Vérité, Fabien; Bachta, Wael; Morel, Guillaume

    2014-01-01

    Postural control rehabilitation may benefit from the use of smart devices providing biofeedback. This approach consists of increasing the patients perception of their postural state. Namely, postural state is monitored and fed back in real time to the patients through one or more sensory channels. This allows implementing rehabilitation exercises where the patients control their posture with the help of additional sensory inputs. In this paper, a closed loop control of the Center-Of-Pressure (CoP) based on kinesthetic feedback is proposed as a new form of biofeedback. The motion of a one Degree of Freedom (DoF) translational device, lightly touched by the patient's forefinger, is servoed to the patient's CoP position extracted from the measurements of a force plate on which he/she stands. As a result, the patient's CoP can be controllably displaced. A first set of experiments is used to prove the feasibility of this closed-loop control under ideal conditions favoring the perception of the kinesthetic feedback, while the subject is totally unaware of the context. A second set of experiments is then proposed to evaluate the robustness of this approach under experimental conditions that are more realistic with regards to the clinical context of a rehabilitation program involving biofeedback-based exercises.

  7. Dynamical consequences of bandpass feedback loops in a bacterial phosphorelay.

    Directory of Open Access Journals (Sweden)

    Shaunak Sen

    Full Text Available Under conditions of nutrient limitation, Bacillus subtilis cells terminally differentiate into a dormant spore state. Progression to sporulation is controlled by a genetic circuit consisting of a phosphorelay embedded in multiple transcriptional feedback loops, which is used to activate the master regulator Spo0A by phosphorylation. These transcriptional regulatory interactions are "bandpass"-like, in the sense that activation occurs within a limited band of Spo0A∼P concentrations. Additionally, recent results show that the phosphorelay activation occurs in pulses, in a cell-cycle dependent fashion. However, the impact of these pulsed bandpass interactions on the circuit dynamics preceding sporulation remains unclear. In order to address this question, we measured key features of the bandpass interactions at the single-cell level and analyzed them in the context of a simple mathematical model. The model predicted the emergence of a delayed phase shift between the pulsing activity of the different sporulation genes, as well as the existence of a stable state, with elevated Spo0A activity but no sporulation, embedded within the dynamical structure of the system. To test the model, we used time-lapse fluorescence microscopy to measure dynamics of single cells initiating sporulation. We observed the delayed phase shift emerging during the progression to sporulation, while a re-engineering of the sporulation circuit revealed behavior resembling the predicted additional state. These results show that periodically-driven bandpass feedback loops can give rise to complex dynamics in the progression towards sporulation.

  8. Practical Loop-Shaping Design of Feedback Control Systems

    Science.gov (United States)

    Kopasakis, George

    2010-01-01

    An improved methodology for designing feedback control systems has been developed based on systematically shaping the loop gain of the system to meet performance requirements such as stability margins, disturbance attenuation, and transient response, while taking into account the actuation system limitations such as actuation rates and range. Loop-shaping for controls design is not new, but past techniques do not directly address how to systematically design the controller to maximize its performance. As a result, classical feedback control systems are designed predominantly using ad hoc control design approaches such as proportional integral derivative (PID), normally satisfied when a workable solution is achieved, without a good understanding of how to maximize the effectiveness of the control design in terms of competing performance requirements, in relation to the limitations of the plant design. The conception of this improved methodology was motivated by challenges in designing control systems of the types needed for supersonic propulsion. But the methodology is generally applicable to any classical control-system design where the transfer function of the plant is known or can be evaluated. In the case of a supersonic aerospace vehicle, a major challenge is to design the system to attenuate anticipated external and internal disturbances, using such actuators as fuel injectors and valves, bypass doors, and ramps, all of which are subject to limitations in actuator response, rates, and ranges. Also, for supersonic vehicles, with long slim type of structures, coupling between the engine and the structural dynamics can produce undesirable effects that could adversely affect vehicle stability and ride quality. In order to design distributed controls that can suppress these potential adverse effects, within the full capabilities of the actuation system, it is important to employ a systematic control design methodology such as this that can maximize the

  9. LOOP-3, Hydraulic Stability in Heated Parallel Channels

    Energy Technology Data Exchange (ETDEWEB)

    Davies, A L [AEEW, Dorset (United Kingdom)

    1968-02-01

    1 - Nature of physical problem solved: Hydraulic stability in parallel channels. 2 - Method of solution: Calculation of transfer functions developed in reference (10 below). 3 - Restrictions on the complexity of the problem: Only due to assumptions in analysis (see ref.)

  10. Silicon photonic dynamic optical channel leveler with external feedback loop.

    Science.gov (United States)

    Doylend, J K; Jessop, P E; Knights, A P

    2010-06-21

    We demonstrate a dynamic optical channel leveler composed of a variable optical attenuator (VOA) integrated monolithically with a defect-mediated photodiode in a silicon photonic waveguide device. An external feedback loop mimics an analog circuit such that the photodiode directly controls the VOA to provide blind channel leveling within +/-1 dB across a 7-10 dB dynamic range for wavelengths from 1530 nm to 1570 nm. The device consumes approximately 50 mW electrical power and occupies a 6 mm x 0.1 mm footprint per channel. Dynamic leveling is accomplished without tapping optical power from the output path to the photodiode and thus the loss penalty is minimized.

  11. Computational Model of a Positive BDNF Feedback Loop in Hippocampal Neurons Following Inhibitory Avoidance Training

    Science.gov (United States)

    Zhang, Yili; Smolen, Paul; Alberini, Cristina M.; Baxter, Douglas A.; Byrne, John H.

    2016-01-01

    Inhibitory avoidance (IA) training in rodents initiates a molecular cascade within hippocampal neurons. This cascade contributes to the transition of short- to long-term memory (i.e., consolidation). Here, a differential equation-based model was developed to describe a positive feedback loop within this molecular cascade. The feedback loop begins…

  12. Controlling a negative loaded hydraulic cylinder using pressure feedback

    DEFF Research Database (Denmark)

    Hansen, M.R.; Andersen, T.O.

    2010-01-01

    This paper is concerned with the inherent oscillatory nature of pressure compensated velocity control of a hydraulic cylinder subjected to a negative load and suspended by means of an over-center valve. Initially, a linearized stability analysis of such a hydraulic circuit is carried out clearly ...... in a nonlinear time domain simulation model validating the linear stability analysis....

  13. Real-time tracking control of electro-hydraulic force servo systems using offline feedback control and adaptive control.

    Science.gov (United States)

    Shen, Gang; Zhu, Zhencai; Zhao, Jinsong; Zhu, Weidong; Tang, Yu; Li, Xiang

    2017-03-01

    This paper focuses on an application of an electro-hydraulic force tracking controller combined with an offline designed feedback controller (ODFC) and an online adaptive compensator in order to improve force tracking performance of an electro-hydraulic force servo system (EHFS). A proportional-integral controller has been employed and a parameter-based force closed-loop transfer function of the EHFS is identified by a continuous system identification algorithm. By taking the identified system model as a nominal plant model, an H ∞ offline design method is employed to establish an optimized feedback controller with consideration of the performance, control efforts, and robustness of the EHFS. In order to overcome the disadvantage of the offline designed controller and cope with the varying dynamics of the EHFS, an online adaptive compensator with a normalized least-mean-square algorithm is cascaded to the force closed-loop system of the EHFS compensated by the ODFC. Some comparative experiments are carried out on a real-time EHFS using an xPC rapid prototype technology, and the proposed controller yields a better force tracking performance improvement. Copyright © 2016. Published by Elsevier Ltd.

  14. Analysis of beam feedback loops of RF acceleration system at TARN II

    International Nuclear Information System (INIS)

    Katayama, Takeshi.

    1992-08-01

    Two beam-feedback-loops are prepared for the frequency control of RF acceleration system at cooler-synchrotron TARN II. One is the phase-loop and the other the radial-position-loop. In the present paper, the effects of these loops on the beam dynamics in the synchrotron are studied on the basis of Laplace transformation approach as well as the numerical values for the synchrotron acceleration at TARN II. (author)

  15. Output Feedback Control of Electro-Hydraulic Cylinder Drives using the Twisting Algorithm

    DEFF Research Database (Denmark)

    Schmidt, Lasse; Andersen, Torben Ole; Pedersen, Henrik C.

    2014-01-01

    contributions in literature. This paper considers the twisting algorithm when applied directly for output feedback control, and with the design based on a reduced order model representation of an arbitrary valve driven hydraulic cylinder drive. The consequence of implementing such a controller with the well......This paper discusses the utilization of the so-called twisting algorithm when applied in output feedback position control schemes for electro-hydraulic cylinder drives. The twisting controller was the first second order sliding controller ever introduced, and can structure-wise be considered...... feedback controller may be successfully applied to hydraulic valve driven cylinder drives, with performance being on the level with a conventional surface based first order sliding mode controller....

  16. Hydraulic engine valve actuation system including independent feedback control

    Science.gov (United States)

    Marriott, Craig D

    2013-06-04

    A hydraulic valve actuation assembly may include a housing, a piston, a supply control valve, a closing control valve, and an opening control valve. The housing may define a first fluid chamber, a second fluid chamber, and a third fluid chamber. The piston may be axially secured to an engine valve and located within the first, second and third fluid chambers. The supply control valve may control a hydraulic fluid supply to the piston. The closing control valve may be located between the supply control valve and the second fluid chamber and may control fluid flow from the second fluid chamber to the supply control valve. The opening control valve may be located between the supply control valve and the second fluid chamber and may control fluid flow from the supply control valve to the second fluid chamber.

  17. Time Optimal Synchronization Procedure and Associated Feedback Loops

    CERN Document Server

    Angoletta, Maria Elena; CERN. Geneva. ATS Department

    2016-01-01

    A procedure to increase the speed of currently used synchronization loops in a synchrotron by an order of magnitude is presented. Beams dynamics constraint imposes an upper limit on excursions in stable phase angle, and the procedure presented exploits this limit to arrive in the synchronized state from an arbitrary initial state in the fastest possible way. Detailed corrector design for beam phase loop, differential frequency loop and final synchronization loop is also presented. Finally, an overview of the synchronization methods currently deployed in some other CERN’s machines is provided, together with a brief comparison with the newly proposed time-optimal algorithm.

  18. Closed-loop multiple antenna aided wireless communications using limited feedback

    OpenAIRE

    Yang, Du

    2010-01-01

    The aim of this thesis is to study the design of closed-loop multiple antenna aided wireless communications relying on limited feedback. Multiple antennas may be employed either/both at the transmitter or/and at the receiver, here the latter periodically feeds back some information about the time-varying wireless channel using a limited number of bits. Furthermore, the transmitter then pre-processes the signals to be transmitted according to the received feedback information. This closed-loop...

  19. Interlinked Dual-Time Feedback Loops can Enhance Robustness to Stochasticity and Persistence of Memory

    OpenAIRE

    Smolen, Paul; Baxter, Douglas A.; Byrne, John H.

    2012-01-01

    Multiple interlinked positive feedback loops shape the stimulus responses of various biochemical systems, such as the cell cycle or intracellular Ca2+ release. Recent studies with simplified models have identified two advantages of coupling fast and slow feedback loops. This dual-time structure enables a fast response while enhancing resistances of responses and bistability to stimulus noise. We now find that: 1) the dual-time structure similarly confers resistance to internal noise due to mo...

  20. Feedback loops and reciprocal regulation: recurring motifs in the systems biology of the cell cycle

    OpenAIRE

    Ferrell, James E.

    2013-01-01

    The study of eukaryotic cell cycle regulation over the last several decades has led to a remarkably detailed understanding of the complex regulatory system that drives this fundamental process. This allows us to now look for recurring motifs in the regulatory system. Among these are negative feedback loops, which underpin checkpoints and generate cell cycle oscillations; positive feedback loops, which promote oscillations and make cell cycle transitions switch-like and unidirectional; and rec...

  1. Beam stability in synchrotrons with digital filters in the feedback loop of a transverse damper

    International Nuclear Information System (INIS)

    Zhabitskij, V.M.

    2009-01-01

    The stability of an ion beam in synchrotrons with digital filters in the feedback loop of a transverse damper is treated. Solving the characteristic equation allows one to calculate the achievable damping rates as a function of instability growth rate, feedback gain and parameters of the signal processing. A transverse feedback system (TFS) is required in synchrotrons to stabilize the high intensity ion beams against transverse instabilities and to damp the beam injection errors. The TFS damper kicker (DK) corrects the transverse momentum of a bunch in proportion to its displacement from the closed orbit at the location of the beam position monitor (BPM). The digital signal processing unit in the feedback loop between BPM and DK ensures a condition to achieve optimal damping. Damping rates of the feedback systems with digital notch, Hilbert and all-pass filters are analyzed in comparison with those in an ideal feedback system

  2. Thermal-hydraulic feedback model to calculate the neutronic cross-section in PWR reactions

    International Nuclear Information System (INIS)

    Santiago, Daniela Maiolino Norberto

    2011-01-01

    In neutronic codes,it is important to have a thermal-hydraulic feedback module. This module calculates the thermal-hydraulic feedback of the fuel, that feeds the neutronic cross sections. In the neutronic co de developed at PEN / COPPE / UFRJ, the fuel temperature is obtained through an empirical model. This work presents a physical model to calculate this temperature. We used the finite volume technique of discretized the equation of temperature distribution, while calculation the moderator coefficient of heat transfer, was carried out using the ASME table, and using some of their routines to our program. The model allows one to calculate an average radial temperature per node, since the thermal-hydraulic feedback must follow the conditions imposed by the neutronic code. The results were compared with to the empirical model. Our results show that for the fuel elements near periphery, the empirical model overestimates the temperature in the fuel, as compared to our model, which may indicate that the physical model is more appropriate to calculate the thermal-hydraulic feedback temperatures. The proposed model was validated by the neutronic simulator developed in the PEN / COPPE / UFRJ for analysis of PWR reactors. (author)

  3. Strategic need for a multi-purpose thermal hydraulic loop for support of advanced reactor technologies

    Energy Technology Data Exchange (ETDEWEB)

    O' Brien, James E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sabharwall, Piyush [Idaho National Lab. (INL), Idaho Falls, ID (United States); Yoon, Su -Jong [Idaho National Lab. (INL), Idaho Falls, ID (United States); Housley, Gregory K. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-09-01

    This report presents a conceptual design for a new high-temperature multi fluid, multi loop test facility for the INL to support thermal hydraulic, materials, and thermal energy storage research for nuclear and nuclear-hybrid applications. In its initial configuration, the facility will include a high-temperature helium loop, a liquid salt loop, and a hot water/steam loop. The three loops will be thermally coupled through an intermediate heat exchanger (IHX) and a secondary heat exchanger (SHX). Research topics to be addressed with this facility include the characterization and performance evaluation of candidate compact heat exchangers such as printed circuit heat exchangers (PCHEs) at prototypical operating conditions, flow and heat transfer issues related to core thermal hydraulics in advanced helium-cooled and salt-cooled reactors, and evaluation of corrosion behavior of new cladding materials and accident-tolerant fuels for LWRs at prototypical conditions. Based on its relevance to advanced reactor systems, the new facility has been named the Advanced Reactor Technology Integral System Test (ARTIST) facility. Research performed in this facility will advance the state of the art and technology readiness level of high temperature intermediate heat exchangers (IHXs) for nuclear applications while establishing the INL as a center of excellence for the development and certification of this technology. The thermal energy storage capability will support research and demonstration activities related to process heat delivery for a variety of hybrid energy systems and grid stabilization strategies. Experimental results obtained from this research will assist in development of reliable predictive models for thermal hydraulic design and safety codes over the range of expected advanced reactor operating conditions. Proposed/existing IHX heat transfer and friction correlations and criteria will be assessed with information on materials compatibility and instrumentation

  4. FX2-TH: a two-dimensional nuclear reactor kinetics code with thermal-hydraulic feedback

    International Nuclear Information System (INIS)

    Shober, R.A.; Daly, T.A.; Ferguson, D.R.

    1978-10-01

    FX2-TH is a two-dimensional, time-dependent nuclear reactor kinetics program with thermal and hydraulic feedback. The neutronics model used is multigroup neutron diffusion theory. The following geometry options are available: x, r, x-y, r-z, theta-r, and triangular. FX2-TH contains two basic thermal and hydraulic models: a simple adiabatic fuel temperature calculation, and a more detailed model consisting of an explicit representation of a fuel pin, gap, clad, and coolant. FX2-TH allows feedback effects from both fuel temperature (Doppler) and coolant temperature (density) changes. FX2-TH will calculate a consistent set of steady state conditions by iterating between the neutronics and thermal-hydraulics until convergence is reached. The time-dependent calculation is performed by the use of the improved quasistatic method. A disk editing capability is available. FX2-TH is operational on IBM system 360 or 370 computers and on the CDC 7600

  5. Hydraulic noise in reactor circuits and loops, and its effect on nuclear fuel vibration

    International Nuclear Information System (INIS)

    Card, D.C.

    This paper reports the results of an investigation at WNRE to monitor noise levels in reactor circuits and loops, so as to characterize the systems and establish the importance of this noise on fuel and pressure tube vibration. Some of the techniques necessary for in-reactor installations of pressure transducers have been developed and measurements have been obtained in the vertical fuel channels of a very noisy out-reactor loop as well as in the WR-1 reactor circuits. A very quiet out-reactor loop has been constructed to study the vibration behaviour of 37-element fuel bundles in the horizontal CANDU pressurized-heavy water reactor systems. In this facility various types and levels of hydraulic noise are being generated to study their effect on the fuel bundles and flow tube at flow velocities up to approximately 13 m/s. (author)

  6. Modal space three-state feedback control for electro-hydraulic servo plane redundant driving mechanism with eccentric load decoupling.

    Science.gov (United States)

    Zhao, Jinsong; Wang, Zhipeng; Zhang, Chuanbi; Yang, Chifu; Bai, Wenjie; Zhao, Zining

    2018-06-01

    The shaking table based on electro-hydraulic servo parallel mechanism has the advantage of strong carrying capacity. However, the strong coupling caused by the eccentric load not only affects the degree of freedom space control precision, but also brings trouble to the system control. A novel decoupling control strategy is proposed, which is based on modal space to solve the coupling problem for parallel mechanism with eccentric load. The phenomenon of strong dynamic coupling among degree of freedom space is described by experiments, and its influence on control design is discussed. Considering the particularity of plane motion, the dynamic model is built by Lagrangian method to avoid complex calculations. The dynamic equations of the coupling physical space are transformed into the dynamic equations of the decoupling modal space by using the weighted orthogonality of the modal main mode with respect to mass matrix and stiffness matrix. In the modal space, the adjustments of the modal channels are independent of each other. Moreover, the paper discusses identical closed-loop dynamic characteristics of modal channels, which will realize decoupling for degree of freedom space, thus a modal space three-state feedback control is proposed to expand the frequency bandwidth of each modal channel for ensuring their near-identical responses in a larger frequency range. Experimental results show that the concept of modal space three-state feedback control proposed in this paper can effectively reduce the strong coupling problem of degree of freedom space channels, which verify the effectiveness of the proposed model space state feedback control strategy for improving the control performance of the electro-hydraulic servo plane redundant driving mechanism. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.

  7. Linking Multimodal Communication and Feedback Loops to Reinforce Plagiarism Awareness

    Science.gov (United States)

    O'Donnell, Kerri

    2011-01-01

    In this article, the author describes the use of an electronic quiz on a trial basis as a means of improving students' awareness of academic misconduct issues and their understanding of how to avoid those issues. The quiz integrated several new factors into information-sharing processes, increasing feedback to both students and staff. It was by no…

  8. Thermal-hydraulic calculation and water hammer analysis on CEFR loop system

    International Nuclear Information System (INIS)

    Hao Pengfei; Zhang Xiwen; Cai Weidong; Wang Xuefang

    1997-01-01

    China Experimental Fast Reactor (CEFR) is one of the '863' High-technical Projects. It is necessary to study the hydraulic and thermal Characteristic of CEFR loop system in order to guarantee the safety of operation. The results of the thermal-hydraulic calculation have been given. The main points are as follows: 1. The simplified model is built according to the loop system of CEFR, and the calculation method which is called 'NODE'-'BRANCH' is applied. This method includes two aspects, one is the theoretical analysis that is based on fluid mechanics and heat transfer theory. The other is the engineering calculation. These two aspects are connected in the computation. On the basis of the work mentioned above, the stable state computation is presented. In order to prevent serious damage caused by power failure accident, the courses of surplus reactor heat removing through two different systems have been simulated in the computation. 2. By using the fluid dynamics theory, the simplified model and the equipment boundary conditions of loop system are given. The water hammer computation is processed during the valve closing and pump stopping accidents. Some pictures of water hammer wave are presented, and the most dangerous state in the accident is also given

  9. Asymmetric positive feedback loops reliably control biological responses.

    Science.gov (United States)

    Ratushny, Alexander V; Saleem, Ramsey A; Sitko, Katherine; Ramsey, Stephen A; Aitchison, John D

    2012-04-24

    Positive feedback is a common mechanism enabling biological systems to respond to stimuli in a switch-like manner. Such systems are often characterized by the requisite formation of a heterodimer where only one of the pair is subject to feedback. This ASymmetric Self-UpREgulation (ASSURE) motif is central to many biological systems, including cholesterol homeostasis (LXRα/RXRα), adipocyte differentiation (PPARγ/RXRα), development and differentiation (RAR/RXR), myogenesis (MyoD/E12) and cellular antiviral defense (IRF3/IRF7). To understand why this motif is so prevalent, we examined its properties in an evolutionarily conserved transcriptional regulatory network in yeast (Oaf1p/Pip2p). We demonstrate that the asymmetry in positive feedback confers a competitive advantage and allows the system to robustly increase its responsiveness while precisely tuning the response to a consistent level in the presence of varying stimuli. This study reveals evolutionary advantages for the ASSURE motif, and mechanisms for control, that are relevant to pharmacologic intervention and synthetic biology applications.

  10. Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder.

    Science.gov (United States)

    Wittenborn, A K; Rahmandad, H; Rick, J; Hosseinichimeh, N

    2016-02-01

    Depression is a complex public health problem with considerable variation in treatment response. The systemic complexity of depression, or the feedback processes among diverse drivers of the disorder, contribute to the persistence of depression. This paper extends prior attempts to understand the complex causal feedback mechanisms that underlie depression by presenting the first broad boundary causal loop diagram of depression dynamics. We applied qualitative system dynamics methods to map the broad feedback mechanisms of depression. We used a structured approach to identify candidate causal mechanisms of depression in the literature. We assessed the strength of empirical support for each mechanism and prioritized those with support from validation studies. Through an iterative process, we synthesized the empirical literature and created a conceptual model of major depressive disorder. The literature review and synthesis resulted in the development of the first causal loop diagram of reinforcing feedback processes of depression. It proposes candidate drivers of illness, or inertial factors, and their temporal functioning, as well as the interactions among drivers of depression. The final causal loop diagram defines 13 key reinforcing feedback loops that involve nine candidate drivers of depression. Future research is needed to expand upon this initial model of depression dynamics. Quantitative extensions may result in a better understanding of the systemic syndrome of depression and contribute to personalized methods of evaluation, prevention and intervention.

  11. PETER loop. Multifunctional test facility for thermal hydraulic investigations of PWR fuel elements

    International Nuclear Information System (INIS)

    Ganzmann, I.; Hille, D.; Staude, U.

    2009-01-01

    The reliable fuel element behavior during the complete fuel cycle is one of the fundamental prerequisites of a safe and efficient nuclear power plant operation. The fuel element behavior with respect to pressure drop and vibration impact cannot be simulated by means of fluid-structure interaction codes. Therefore it is necessary to perform tests using fuel element mock-ups (1:1). AREVA NP has constructed the test facility PETER (PWR fuel element tests in Erlangen) loop. The modular construction allows maximum flexibility for any type of fuel elements. Modern measuring instrumentation for flow, pressure and vibration characterization allows the analysis of cause and consequences of thermal hydraulic phenomena. PETER loop is the standard test facility for the qualification of dynamic fuel element behavior in flowing fluid and is used for failure mode analysis.

  12. Closing the Feedback Loop: Physics Undergraduates' Use of Feedback Comments on Laboratory Coursework

    Science.gov (United States)

    Donovan, Pam

    2014-01-01

    The laboratory notebooks of physics undergraduates taking two second-year practical courses were audited to discover whether they had used feedback comments in their subsequent coursework. Ninety-five per cent of the 37 students on the first course and 100% of the 14 students on the second course whose work was audited had used feedback. The…

  13. Application of second order sliding mode algorithms for output feedback control in hydraulic cylinder drives with profound valve dynamics

    DEFF Research Database (Denmark)

    Schmidt, Lasse; Andersen, Torben O.

    2016-01-01

    The application of second order sliding mode algorithms for output feedback control in hydraulic valve-cylinder drives appear attractive due to their simple realization and parametrization, and strong robustness toward bounded parameter variations and uncertainties. However, intrinsic nonlinear...

  14. Modulation of dynamic modes by interplay between positive and negative feedback loops in gene regulatory networks

    Science.gov (United States)

    Wang, Liu-Suo; Li, Ning-Xi; Chen, Jing-Jia; Zhang, Xiao-Peng; Liu, Feng; Wang, Wei

    2018-04-01

    A positive and a negative feedback loop can induce bistability and oscillation, respectively, in biological networks. Nevertheless, they are frequently interlinked to perform more elaborate functions in many gene regulatory networks. Coupled positive and negative feedback loops may exhibit either oscillation or bistability depending on the intensity of the stimulus in some particular networks. It is less understood how the transition between the two dynamic modes is modulated by the positive and negative feedback loops. We developed an abstract model of such systems, largely based on the core p53 pathway, to explore the mechanism for the transformation of dynamic behaviors. Our results show that enhancing the positive feedback may promote or suppress oscillations depending on the strength of both feedback loops. We found that the system oscillates with low amplitudes in response to a moderate stimulus and switches to the on state upon a strong stimulus. When the positive feedback is activated much later than the negative one in response to a strong stimulus, the system exhibits long-term oscillations before switching to the on state. We explain this intriguing phenomenon using quasistatic approximation. Moreover, early switching to the on state may occur when the system starts from a steady state in the absence of stimuli. The interplay between the positive and negative feedback plays a key role in the transitions between oscillation and bistability. Of note, our conclusions should be applicable only to some specific gene regulatory networks, especially the p53 network, in which both oscillation and bistability exist in response to a certain type of stimulus. Our work also underscores the significance of transient dynamics in determining cellular outcome.

  15. Thermal-Hydraulic Sensitivity Study of Intermediate Loop Parameters for Nuclear Hydrogen Production System

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Jong Hwa; Lee, Heung Nae; Park, Jea Ho [KONES Corp., Seoul (Korea, Republic of); Lee, Won Jae [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Lee, Sang Il; Yoo, Yeon Jae [Hyundai Engineering Co., Seoul (Korea, Republic of)

    2016-10-15

    The heat generated from the VHTR is transferred to the intermediate loop through Intermediate Heat Exchanger (IHX). It is further passed on to the Sulfur-Iodine (SI) hydrogen production system (HPS) through Process Heat Exchanger (PHX). The IL provides the safety distance between the VHTR and HPS. Since the IL performance affects the overall nuclear HPS efficiency, it is required to optimize its design and operation parameters. In this study, the thermal-hydraulic sensitivity of IL parameters with various coolant options has been examined by using MARS-GCR code, which was already applied for the case of steam generator. Sensitivity study of the IL and PHX parameters has been carried out based on their thermal-hydraulic performance. Several parameters for design and operation, such as the pipe diameter, safety distance and surface area, are considered for different coolant options, He, CO{sub 2} and He-CO{sub 2} (2:8). It was found that the circulator work is the major factor affecting on the overall nuclear hydrogen production system efficiency. Circulator work increases with the safety distance, and decreases with the operation pressure and loop pipe diameter. Sensitivity results obtained from this study will contribute to the optimization of the IL design and operation parameters and the optimal coolant selection.

  16. The combination of positive and negative feedback loops confers exquisite flexibility to biochemical switches

    International Nuclear Information System (INIS)

    Pfeuty, Benjamin; Kaneko, Kunihiko

    2009-01-01

    A wide range of cellular processes require molecular regulatory pathways to convert a graded signal into a discrete response. One prevalent switching mechanism relies on the coexistence of two stable states (bistability) caused by positive feedback regulations. Intriguingly, positive feedback is often supplemented with negative feedback, raising the question of whether and how these two types of feedback can cooperate to control discrete cellular responses. To address this issue, we formulate a canonical model of a protein–protein interaction network and analyze the dynamics of a prototypical two-component circuit. The appropriate combination of negative and positive feedback loops can bring a bistable circuit close to the oscillatory regime. Notably, sharply activated negative feedback can give rise to a bistable regime wherein two stable fixed points coexist and may collide pairwise with two saddle points. This specific type of bistability is found to allow for separate and flexible control of switch-on and switch-off events, for example (i) to combine fast and reversible transitions, (ii) to enable transient switching responses and (iii) to display tunable noise-induced transition rates. Finally, we discuss the relevance of such bistable switching behavior, and the circuit topologies considered, to specific biological processes such as adaptive metabolic responses, stochastic fate decisions and cell-cycle transitions. Taken together, our results suggest an efficient mechanism by which positive and negative feedback loops cooperate to drive the flexible and multifaceted switching behaviors arising in biological systems

  17. Interlinked dual-time feedback loops can enhance robustness to stochasticity and persistence of memory.

    Science.gov (United States)

    Smolen, Paul; Baxter, Douglas A; Byrne, John H

    2009-03-01

    Multiple interlinked positive feedback loops shape the stimulus responses of various biochemical systems, such as the cell cycle or intracellular Ca2+ release. Recent studies with simplified models have identified two advantages of coupling fast and slow feedback loops. This dual-time structure enables a fast response while enhancing resistances of responses and bistability to stimulus noise. We now find that (1) the dual-time structure similarly confers resistance to internal noise due to molecule number fluctuations, and (2) model variants with altered coupling, which better represent some specific biochemical systems, share all the above advantages. We also develop a similar bistable model with coupling of a fast autoactivation loop to a slow loop. This model's topology was suggested by positive feedback proposed to play a role in long-term synaptic potentiation (LTP). The advantages of fast response and noise resistance are also present in this autoactivation model. Empirically, LTP develops resistance to reversal over approximately 1h . The model suggests this resistance may result from increased amounts of synaptic kinases involved in positive feedback.

  18. Closing the sensorimotor loop: haptic feedback facilitates decoding of motor imagery

    Science.gov (United States)

    Gomez-Rodriguez, M.; Peters, J.; Hill, J.; Schölkopf, B.; Gharabaghi, A.; Grosse-Wentrup, M.

    2011-06-01

    The combination of brain-computer interfaces (BCIs) with robot-assisted physical therapy constitutes a promising approach to neurorehabilitation of patients with severe hemiparetic syndromes caused by cerebrovascular brain damage (e.g. stroke) and other neurological conditions. In such a scenario, a key aspect is how to reestablish the disrupted sensorimotor feedback loop. However, to date it is an open question how artificially closing the sensorimotor feedback loop influences the decoding performance of a BCI. In this paper, we answer this issue by studying six healthy subjects and two stroke patients. We present empirical evidence that haptic feedback, provided by a seven degrees of freedom robotic arm, facilitates online decoding of arm movement intention. The results support the feasibility of future rehabilitative treatments based on the combination of robot-assisted physical therapy with BCIs.

  19. Can we observe open loop transfer functions in a stochastic feedback system ?

    International Nuclear Information System (INIS)

    Kishida, Kuniharu; Suda, Nobuhide.

    1991-01-01

    There are two kinds of problems concerning open loop and closed loop transfer functions in a feedback system. One is a problem even in the deterministic case, and the other is in the stochastic case. In the deterministic case it is guaranteed under a necessary and sufficient condition that total sum of degrees of sub-transfer functions coincides to the degree of the total system. In the stochastic case a systematic understanding of a physical state model, a theoretical innovation model and a data-oriented innovation model is indispensable for determination of open loop transfer functions from time series data. Undesirable factors appear in determination of open loop transfer functions, since a transfer function matrix from input noises to output variables has a redundancy factor of diagonal matrix. (author)

  20. A dynamic-biased dual-loop-feedback CMOS LDO regulator with fast transient response

    International Nuclear Information System (INIS)

    Wang Han; Sun Maomao

    2014-01-01

    This paper presents a low-dropout regulator (LDO) for portable applications with dual-loop feedback and a dynamic bias circuit. The dual-loop feedback structure is adopted to reduce the output voltage spike and the response time of the LDO. The dynamic bias circuit enhances the slew rate at the gate of the power transistor. In addition, an adaptive miller compensation technique is employed, from which a single pole system is realized and over a 59° phase margin is achieved under the full range of the load current. The proposed LDO has been implemented in a 0.6-μm CMOS process. From the experimental results, the regulator can operate with a minimum dropout voltage of 200 mV at a maximum 300 mA load and I Q of 113 μA. The line regulation and load regulation are improved to 0.1 mV/V and 3.4 μV/mA due to the sufficient loop gain provided by the dual feedback loops. Under a full range load current step, the voltage spikes and the recovery time of the proposed LDO is reduced to 97 mV and 0.142 μs respectively. (semiconductor integrated circuits)

  1. Uncovering the spatially distant feedback loops of global trade: A network and input-output approach.

    Science.gov (United States)

    Prell, Christina; Sun, Laixiang; Feng, Kuishuang; He, Jiaying; Hubacek, Klaus

    2017-05-15

    Land-use change is increasingly driven by global trade. The term "telecoupling" has been gaining ground as a means to describe how human actions in one part of the world can have spatially distant impacts on land and land-use in another. These interactions can, over time, create both direct and spatially distant feedback loops, in which human activity and land use mutually impact one another over great expanses. In this paper, we develop an analytical framework to clarify spatially distant feedbacks in the case of land use and global trade. We use an innovative mix of multi-regional input-output (MRIO) analysis and stochastic actor-oriented models (SAOMs) for analyzing the co-evolution of changes in trade network patterns with those of land use, as embodied in trade. Our results indicate that the formation of trade ties and changes in embodied land use mutually impact one another, and further, that these changes are linked to disparities in countries' wealth. Through identifying this feedback loop, our results support ongoing discussions about the unequal trade patterns between rich and poor countries that result in uneven distributions of negative environmental impacts. Finally, evidence for this feedback loop is present even when controlling for a number of underlying mechanisms, such as countries' land endowments, their geographical distance from one another, and a number of endogenous network tendencies. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Smart Braid Feedback for the Closed-Loop Control of Soft Robotic Systems.

    Science.gov (United States)

    Felt, Wyatt; Chin, Khai Yi; Remy, C David

    2017-09-01

    This article experimentally investigates the potential of using flexible, inductance-based contraction sensors in the closed-loop motion control of soft robots. Accurate motion control remains a highly challenging task for soft robotic systems. Precise models of the actuation dynamics and environmental interactions are often unavailable. This renders open-loop control impossible, while closed-loop control suffers from a lack of suitable feedback. Conventional motion sensors, such as linear or rotary encoders, are difficult to adapt to robots that lack discrete mechanical joints. The rigid nature of these sensors runs contrary to the aspirational benefits of soft systems. As truly soft sensor solutions are still in their infancy, motion control of soft robots has so far relied on laboratory-based sensing systems such as motion capture, electromagnetic (EM) tracking, or Fiber Bragg Gratings. In this article, we used embedded flexible sensors known as Smart Braids to sense the contraction of McKibben muscles through changes in inductance. We evaluated closed-loop control on two systems: a revolute joint and a planar, one degree of freedom continuum manipulator. In the revolute joint, our proposed controller compensated for elasticity in the actuator connections. The Smart Braid feedback allowed motion control with a steady-state root-mean-square (RMS) error of [1.5]°. In the continuum manipulator, Smart Braid feedback enabled tracking of the desired tip angle with a steady-state RMS error of [1.25]°. This work demonstrates that Smart Braid sensors can provide accurate position feedback in closed-loop motion control suitable for field applications of soft robotic systems.

  3. FLICA III. A digital computer program for thermal-hydraulic analysis of reactors and experimental loops

    International Nuclear Information System (INIS)

    Plas, Roger.

    1975-05-01

    This computer program describes the flow and heat transfer in steady and transient state in two-phase flows. It is the present stage of the evolution about FLICA, FLICA II and FLICA II B codes which have been used and developed at CEA for the thermal-hydraulic analysis of reactors and experimental loops with heating rod bundles. In the mathematical model all the significant terms of the fundamental hydrodynamic equations are taken into account with the approximations of turbulent viscosity and conductivity. The two-phase flow is calculated by the homogeneous model with slip. In the flow direction an implicit resolution scheme is available, which make possible to study partial or total flow blockage, with upstream and downstream effects. A special model represents the helical wire effects in out-of pile experimental rod bundles [fr

  4. Using Feedback Error Learning for Control of Electro Hydraulic Servo System by Laguerre

    Directory of Open Access Journals (Sweden)

    Amir Reza Zare Bidaki

    2014-01-01

    Full Text Available In this paper, a new Laguerre controller is proposed to control the electro hydraulic servo system. The proposed controller uses feedback error learning method and leads to significantly improve performance in terms of settling time and amplitude of control signal rather than other controllers. All derived results are validated by simulation of nonlinear mathematical model of the system. The simulation results show the advantages of the proposed method for improved control in terms of both settling time and amplitude of control signal.

  5. Nonlinear force feedback control of piezoelectric-hydraulic pump actuator for automotive transmission shift control

    Science.gov (United States)

    Kim, Gi-Woo; Wang, K. W.

    2008-03-01

    In recent years, researchers have investigated the feasibility of utilizing piezoelectric-hydraulic pump based actuation systems for automotive transmission controls. This new concept could eventually reduce the complexity, weight, and fuel consumption of the current transmissions. In this research, we focus on how to utilize this new approach on the shift control of automatic transmissions (AT), which generally requires pressure profiling for friction elements during the operation. To illustrate the concept, we will consider the 1--> 2 up shift control using band brake friction elements. In order to perform the actuation force tracking for AT shift control, nonlinear force feedback control laws are designed based on the sliding mode theory for the given nonlinear system. This paper will describe the modeling of the band brake actuation system, the design of the nonlinear force feedback controller, and simulation and experimental results for demonstration of the new concept.

  6. Feedback versus open-loop leader/fringe models of the oil supply market

    International Nuclear Information System (INIS)

    Pelot, R.P.; Fuller, J.D.

    1991-01-01

    A multiperiod feedback Stackelberg model of exhaustible resources is presented. The results of the feedback model are compared with those from a corresponding open-loop formulation to determine whether the solution to the latter, and much simpler, model produces the same or similar outcomes. An analysis of the world oil market with OPEC as leader dictating the price to a competitive fringe comprised of the remaining oil suppliers demonstrates the features of the model. It permits variable length periods and cumulative extraction cost functions

  7. Negative feedback loops leading to nitrate homeostasis and oscillatory nitrate assimilation in plants and fungi.

    OpenAIRE

    Huang, Yongshun

    2011-01-01

    Master's thesis in Biological Chemistry Nitrate is an important nutrient for plants and fungi. For plants it has been shown that cytosolic nitrate levels are under homeostatic control. Here we describe two networks that can obtain robust, i.e. perturbation independent, homeostatic behavior in cytosolic nitrate concentration. One of the networks, a member in the family of outflow controllers, is based on a negative feedback loop containing a nitrate-induced activation of a controller molecu...

  8. Sp1-CD147 positive feedback loop promotes the invasion ability of ovarian cancer.

    Science.gov (United States)

    Zhao, Jing; Ye, Wei; Wu, Juan; Liu, Lijuan; Yang, Lina; Gao, Lu; Chen, Biliang; Zhang, Fanglin; Yang, Hong; Li, Yu

    2015-07-01

    CD147 is a novel cancer biomarker that has been confirmed to be overexpressed in ovarian carcinoma, which is significantly associated with poor prognosis. Although the Sp1 protein regulates the expression level of CD147, it remains unclear whether Sp1 phosphorylation plays a role in this regulation. A dual-luciferase assay revealed that T453 and T739 mutations decreased the activity of Sp1 binding to the promoter of CD147, followed by a decrease in CD147 mRNA and protein expression. Western blot analysis showed that CD147 promoted Sp1 phosphorylation at T453 and T739 through the PI3K/AKT and MAPK/ERK pathways. In addition, blocking the Sp1-CD147 positive feedback loop reduced the invasion ability of HO-8910pm cells. Immunohistochemical staining showed that the components of the feedback loop were overexpressed in ovarian cancer tissues. The correlation analysis revealed a significant correlation between phospho-Sp1 (T453), phospho-Sp1 (T739) and CD147 expression levels, with correlation coefficients of r=0.477 and r=0.461, respectively. Collectively, our results suggest that a Sp1-CD147 positive feedback loop plays a critical role in the invasion ability of ovarian cancer cells.

  9. Self-reinforcing feedback loop in financial markets with coupling of market impact and momentum traders

    Science.gov (United States)

    Zhong, Li-Xin; Xu, Wen-Juan; Chen, Rong-Da; Zhong, Chen-Yang; Qiu, Tian; Ren, Fei; He, Yun-Xing

    2018-03-01

    By incorporating market impact and momentum traders into an agent-based model, we investigate the conditions for the occurrence of self-reinforcing feedback loops and the coevolutionary mechanism of prices and strategies. For low market impact, the price fluctuations are originally large. The existence of momentum traders has little impact on the change of price fluctuations but destroys the equilibrium between the trend-following and trend-rejecting strategies. The trend-following herd behaviors become dominant. A self-reinforcing feedback loop exists. For high market impact, the existence of momentum traders leads to an increase in price fluctuations. The trend-following strategies of rational individuals are suppressed while the trend-following strategies of momentum traders are promoted. The crowd-anticrowd behaviors become dominant. A negative feedback loop exists. A theoretical analysis indicates that, for low market impact, the majority effect is beneficial for the trend-followers to earn more, which in turn promotes the trend-following strategies. For high market impact, the minority effect causes the trend-followers to suffer great losses, which in turn suppresses the trend-following strategies.

  10. A social feedback loop for speech development and its reduction in autism.

    Science.gov (United States)

    Warlaumont, Anne S; Richards, Jeffrey A; Gilkerson, Jill; Oller, D Kimbrough

    2014-07-01

    We analyzed the microstructure of child-adult interaction during naturalistic, daylong, automatically labeled audio recordings (13,836 hr total) of children (8- to 48-month-olds) with and without autism. We found that an adult was more likely to respond when the child's vocalization was speech related rather than not speech related. In turn, a child's vocalization was more likely to be speech related if the child's previous speech-related vocalization had received an immediate adult response rather than no response. Taken together, these results are consistent with the idea that there is a social feedback loop between child and caregiver that promotes speech development. Although this feedback loop applies in both typical development and autism, children with autism produced proportionally fewer speech-related vocalizations, and the responses they received were less contingent on whether their vocalizations were speech related. We argue that such differences will diminish the strength of the social feedback loop and have cascading effects on speech development over time. Differences related to socioeconomic status are also reported. © The Author(s) 2014.

  11. An evaluation of the feedback loops in the poverty focus of world bank operations.

    Science.gov (United States)

    Fardoust, Shahrokh; Kanbur, Ravi; Luo, Xubei; Sundberg, Mark

    2018-04-01

    The World Bank Group in 2013 made the elimination of extreme poverty by 2030 a central institutional focus and purpose. This paper, based on an evaluation conducted by the Independent Evaluation Group of the World Bank Group, examines how, and how well, the Bank uses feedback loops to enhance the poverty focus of its operations. Feedback loops are important for every element of the results chain running from data, to diagnostics, to strategy formulation and finally to strategy implementation. The evaluation uses a range of instruments, including surveys of stakeholders and World Bank staff, focus group meetings, country case studies and systematic reviews of Bank lending and non-lending operations. We find that while the Bank generates useful information on poverty reduction from its projects and programs, the feedback loops - from outcomes to data analysis to diagnostics to strategy formulation and implementation - have generally been weak, with sizable variation across countries. Copyright © 2017 The World Bank. Published by Elsevier Ltd.. All rights reserved.

  12. A model for improving microbial biofuel production using a synthetic feedback loop

    Energy Technology Data Exchange (ETDEWEB)

    Dunlop, Mary; Keasling, Jay; Mukhopadhyay, Aindrila

    2011-07-14

    Cells use feedback to implement a diverse range of regulatory functions. Building synthetic feedback control systems may yield insight into the roles that feedback can play in regulation since it can be introduced independently of native regulation, and alternative control architectures can be compared. We propose a model for microbial biofuel production where a synthetic control system is used to increase cell viability and biofuel yields. Although microbes can be engineered to produce biofuels, the fuels are often toxic to cell growth, creating a negative feedback loop that limits biofuel production. These toxic effects may be mitigated by expressing efflux pumps that export biofuel from the cell. We developed a model for cell growth and biofuel production and used it to compare several genetic control strategies for their ability to improve biofuel yields. We show that controlling efflux pump expression directly with a biofuel-responsive promoter is a straight forward way of improving biofuel production. In addition, a feed forward loop controller is shown to be versatile at dealing with uncertainty in biofuel production rates.

  13. A Platform for Closing the Open Data Feedback Loop Based on Web2.0 Functionality

    Directory of Open Access Journals (Sweden)

    Charalampos Alexopoulos

    2014-11-01

    Full Text Available One essential element of open data ecosystems concerns their development through feedback loops, discussions and dynamic supplier and user interactions. These user-centric features communicate the users’ needs to the open data community as well to the public sector bodies responsible for data publication. Addressing these needs by the corresponding public sector bodies or even by utilising the power of the community as ENGAGE supports will actually accelerate innovation. However, these elements appear barely to be part of existing open data practices. We conducted a survey which showed that most professional open data users did not know at least one open data infrastructure that enabled five specific types of discussion and feedback mechanisms. The survey showed that much can still be done to improve feedback and discussion on open data infrastructures. In this paper we discuss an open data platform which has started to contribute to filling this gap and present a usage scenario explaining the sequence of the underlined functionality. The discussed ENGAGE open data infrastructure combines functionalities to close the feedback loop and to return information to public authorities for better open data use and publication as well as establishing communication channels between stakeholders. This may effectively lead to the stimulation and facilitation of value generation from open data, as such functionality position the user at the centre of the open data publication process.

  14. Design of a hydraulic loop for characterization of nuclear fuels for the Rech-1

    International Nuclear Information System (INIS)

    Munoz Reveco, David Hernan

    2016-01-01

    The Chilean Nuclear Energy Commission (CCHEN), in particular the Fuels Elements Plant (PEC), wants to increase its capacity of design of nuclear fuel elements (ECN). The International Atomic Energy Agency (IAEA) stipulates that in order to develop new ECN designs must be met with neutron, structural, thermal and hydraulics. The CCHEN in the first instance, wishes to implement the hydraulic tests with a test bench which is called 'Hydraulic Loop (LH)'. The general objective of the project is to design a LH at the level of detailed engineering, with the purpose to characterize ECN hydraulically of the RECH-1 reactor. The specific objectives are: (i) Carry out the conceptual design and control philosophy applicable to the LH, ii) Develop the design LH baseline including layout, equipment, instrumentation and assembly; and iii) Carry out the detailed design for LH construction and assembly including technical specifications for the acquisition, construction and assembly of LH, and estimated investments to materialize the project. To carry out the conceptual design of the LH proceed to review piping projects provided by specialists, fluid pressure drop analysis is carried out in pipelines and papers are reviewed on existing LHs (Petten and IPEN). The basic design is developed by setting the conditions system, taking as a design criterion the operating the RECH-2 reactor. For the design of the test zone, the ASME code VIII division 1 section 13-7. The pond develops according to the capacity of fluid contained in the system. The pump is selected by system losses, overestimating the load of the pump. In addition, the characteristic curves of the pump are compared with the curve feature of the system. Detail planes are generated with Autodesk Inventor software Professional 2014-student version. The instrumentation selection is carried out with the advice of a company dedicated to the measurement and control of industrial activities (VETO). The main results of the project

  15. Recurrent-neural-network-based identification of a cascade hydraulic actuator for closed-loop automotive power transmission control

    International Nuclear Information System (INIS)

    You, Seung Han; Hahn, Jin Oh

    2012-01-01

    By virtue of its ease of operation compared with its conventional manual counterpart, automatic transmissions are commonly used as automotive power transmission control system in today's passenger cars. In accordance with this trend, research efforts on closed-loop automatic transmission controls have been extensively carried out to improve ride quality and fuel economy. State-of-the-art power transmission control algorithms may have limitations in performance because they rely on the steady-state characteristics of the hydraulic actuator rather than fully exploit its dynamic characteristics. Since the ultimate viability of closed-loop power transmission control is dominated by precise pressure control at the level of hydraulic actuator, closed-loop control can potentially attain superior efficacy in case the hydraulic actuator can be easily incorporated into model-based observer/controller design. In this paper, we propose to use a recurrent neural network (RNN) to establish a nonlinear empirical model of a cascade hydraulic actuator in a passenger car automatic transmission, which has potential to be easily incorporated in designing observers and controllers. Experimental analysis is performed to grasp key system characteristics, based on which a nonlinear system identification procedure is carried out. Extensive experimental validation of the established model suggests that it has superb one-step-ahead prediction capability over appropriate frequency range, making it an attractive approach for model-based observer/controller design applications in automotive systems

  16. FY 1995 progress report on the ANS thermal-hydraulic test loop operation and results

    Energy Technology Data Exchange (ETDEWEB)

    Siman-Tov, M.; Felde, D.K.; Farquharson, G.; McDuffee, J.L.; McFee, M.T.; Ruggles, A.E.; Wendel, M.W.; Yoder, G.L.

    1997-07-01

    The Thermal-Hydraulic Test Loop (THTL) is an experimental facility constructed to support the development of the Advanced Neutron Source Reactor (ANSR) at Oak Ridge National Laboratory (ORNL). The THTL facility was designed and built to provide known thermal-hydraulic (T/H) conditions for a simulated full-length coolant subchannel of the ANS reactor core, thus facilitating experimental determination of FE and CHF thermal limits under expected ANSR T/H conditions. Special consideration was given to allow operation of the system in a stiff mode (constant flow) and in a soft mode (constant pressure drop) for proper implementation of true FE and DNB experiments. The facility is also designed to examine other T/H phenomena, including onset of incipient boiling (IB), single-phase heat transfer coefficients and friction factors, and two-phase heat transfer and pressure drop characteristics. Tests will also be conducted that are representative of decay heat levels at both high pressure and low pressure as well as other quasi-equilibrium conditions encountered during transient scenarios. A total of 22 FE tests and 2 CHF tests were performed during FY 1994 and FY 1995 with water flowing vertically upward. Comparison of these data as well as extensive data from other investigators led to a proposed modification to the Saha and Zuber correlation for onset of significant void (OSV), applied to FE prediction. The modification takes into account a demonstrated dependence of the OSV or FE thermal limits on subcooling levels, especially in the low subcooling regime.

  17. FY 1995 progress report on the ANS thermal-hydraulic test loop operation and results

    International Nuclear Information System (INIS)

    Siman-Tov, M.; Felde, D.K.; Farquharson, G.; McDuffee, J.L.; McFee, M.T.; Ruggles, A.E.; Wendel, M.W.; Yoder, G.L.

    1997-07-01

    The Thermal-Hydraulic Test Loop (THTL) is an experimental facility constructed to support the development of the Advanced Neutron Source Reactor (ANSR) at Oak Ridge National Laboratory (ORNL). The THTL facility was designed and built to provide known thermal-hydraulic (T/H) conditions for a simulated full-length coolant subchannel of the ANS reactor core, thus facilitating experimental determination of FE and CHF thermal limits under expected ANSR T/H conditions. Special consideration was given to allow operation of the system in a stiff mode (constant flow) and in a soft mode (constant pressure drop) for proper implementation of true FE and DNB experiments. The facility is also designed to examine other T/H phenomena, including onset of incipient boiling (IB), single-phase heat transfer coefficients and friction factors, and two-phase heat transfer and pressure drop characteristics. Tests will also be conducted that are representative of decay heat levels at both high pressure and low pressure as well as other quasi-equilibrium conditions encountered during transient scenarios. A total of 22 FE tests and 2 CHF tests were performed during FY 1994 and FY 1995 with water flowing vertically upward. Comparison of these data as well as extensive data from other investigators led to a proposed modification to the Saha and Zuber correlation for onset of significant void (OSV), applied to FE prediction. The modification takes into account a demonstrated dependence of the OSV or FE thermal limits on subcooling levels, especially in the low subcooling regime

  18. FY 1993 progress report on the ANS thermal-hydraulic test loop operation and results

    Energy Technology Data Exchange (ETDEWEB)

    Siman-Tov, M.; Felde, D.K.; Farquharson, G. [and others

    1994-07-01

    The Thermal-Hydraulic Test Loop (THTL) is an experimental facility constructed to support the development of the Advanced Neutron Source Reactor (ANSR) at Oak Ridge National Laboratory (ORNL). Highly subcooled heavy-water coolant flows vertically upward at a very high mass flux of almost 27 MG/m{sup 2}-s. In a parallel fuel plate configuration as in the ANSR, the flow is subject to a potential excursive static-flow instability that can very rapidly lead to flow starvation and departure from nucleate boiling (DNB) in the ``hot channel``. The current correlations and experimental data bases for flow excursion (FE) and critical heat flux (CHF) seldom evaluate the specific combination of ANSR operating parameters. The THTL facility was designed and built to provide known thermal-hydraulic (T/H) conditions for a simulated full-length coolant subchannel of the ANS reactor core, thus facilitating experimental determination of FE and CHF thermal limits under expected ANSR T/H conditions. A series of FE tests with water flowing vertically upward was completed over a nominal heat flux range of 6 to 17 MW/m{sup 2}, a mass flux range of 8 to 28 Mg/m{sup 2}-s, an exit pressure range of 1.4 to 2.1 MPa, and an inlet temperature range of 40 to 50 C. FE experiments were also conducted using as ``soft`` a system as possible to secure a true FE phenomena (actual secondary burnout). True DNB experiments under similar conditions were also conducted. To the author`s knowledge, no other FE data have been reported in the literature to date that dover such a combination of conditions of high mass flux, high heat flux, and moderately high pressure.

  19. FY 1993 progress report on the ANS thermal-hydraulic test loop operation and results

    International Nuclear Information System (INIS)

    Siman-Tov, M.; Felde, D.K.; Farquharson, G.

    1994-07-01

    The Thermal-Hydraulic Test Loop (THTL) is an experimental facility constructed to support the development of the Advanced Neutron Source Reactor (ANSR) at Oak Ridge National Laboratory (ORNL). Highly subcooled heavy-water coolant flows vertically upward at a very high mass flux of almost 27 MG/m 2 -s. In a parallel fuel plate configuration as in the ANSR, the flow is subject to a potential excursive static-flow instability that can very rapidly lead to flow starvation and departure from nucleate boiling (DNB) in the ''hot channel''. The current correlations and experimental data bases for flow excursion (FE) and critical heat flux (CHF) seldom evaluate the specific combination of ANSR operating parameters. The THTL facility was designed and built to provide known thermal-hydraulic (T/H) conditions for a simulated full-length coolant subchannel of the ANS reactor core, thus facilitating experimental determination of FE and CHF thermal limits under expected ANSR T/H conditions. A series of FE tests with water flowing vertically upward was completed over a nominal heat flux range of 6 to 17 MW/m 2 , a mass flux range of 8 to 28 Mg/m 2 -s, an exit pressure range of 1.4 to 2.1 MPa, and an inlet temperature range of 40 to 50 C. FE experiments were also conducted using as ''soft'' a system as possible to secure a true FE phenomena (actual secondary burnout). True DNB experiments under similar conditions were also conducted. To the author's knowledge, no other FE data have been reported in the literature to date that dover such a combination of conditions of high mass flux, high heat flux, and moderately high pressure

  20. A computational model clarifies the roles of positive and negative feedback loops in the Drosophila circadian clock

    International Nuclear Information System (INIS)

    Wang Junwei; Zhou Tianshou

    2010-01-01

    Previous studies showed that a single negative feedback structure should be sufficient for robust circadian oscillations. It is thus pertinent to ask why current cellular clock models almost universally have interlocked negative feedback loop (NFL) and positive feedback loop (PFL). Here, we propose a molecular model that reflects the essential features of the Drosophila circadian clock to clarify the different roles of negative and positive feedback loops. In agreement with experimental observations, the model can simulate circadian oscillations in constant darkness, entrainment by light-dark cycles, as well as phenotypes of per 01 and clk Jrk mutants. Moreover, sustained oscillations persist when the PFL is removed, implying the crucial role of NFL for rhythm generation. Through parameter sensitivity analysis, it is revealed that incorporation of PFL increases the robustness of the system to regulatory processes in PFL itself. Such reduced models can aid understanding of the design principles of circadian clocks in Drosophila and other organisms with complex transcriptional feedback structures.

  1. Mode Selection Rules for a Two-Delay System with Positive and Negative Feedback Loops

    Science.gov (United States)

    Takahashi, Kin'ya; Kobayashi, Taizo

    2018-04-01

    The mode selection rules for a two-delay system, which has negative feedback with a short delay time t1 and positive feedback with a long delay time t2, are studied numerically and theoretically. We find two types of mode selection rules depending on the strength of the negative feedback. When the strength of the negative feedback |α1| (α1 0), 2m + 1-th harmonic oscillation is well sustained in a neighborhood of t1/t2 = even/odd, i.e., relevant condition. In a neighborhood of the irrelevant condition given by t1/t2 = odd/even or t1/t2 = odd/odd, higher harmonic oscillations are observed. However, if |α1| is slightly less than α2, a different mode selection rule works, where the condition t1/t2 = odd/even is relevant and the conditions t1/t2 = odd/odd and t1/t2 = even/odd are irrelevant. These mode selection rules are different from the mode selection rule of the normal two-delay system with two positive feedback loops, where t1/t2 = odd/odd is relevant and the others are irrelevant. The two types of mode selection rules are induced by individually different mechanisms controlling the Hopf bifurcation, i.e., the Hopf bifurcation controlled by the "boosted bifurcation process" and by the "anomalous bifurcation process", which occur for |α1| below and above the threshold value αth, respectively.

  2. An Integrated Loop Model of Corrective Feedback and Oral English Learning: A Case of International Students in the United States

    Science.gov (United States)

    Lee, Eun Jeong

    2017-01-01

    The author in this study introduces an integrated corrective feedback (CF) loop to schematize the interplay between CF and independent practice in L2 oral English learning among advanced-level adult ESL students. The CF loop integrates insights from the Interaction, Output, and Noticing Hypotheses to show how CF can help or harm L2 learners'…

  3. Functional characteristics of a double positive feedback loop coupled with autorepression

    International Nuclear Information System (INIS)

    Banerjee, Subhasis; Bose, Indrani

    2008-01-01

    We study the functional characteristics of a two-gene motif consisting of a double positive feedback loop and an autoregulatory negative feedback loop. The motif appears in the gene regulatory network controlling the functional activity of pancreatic β-cells. The model exhibits bistability and hysteresis in appropriate parameter regions. The two stable steady states correspond to low (OFF state) and high (ON state) protein levels, respectively. Using a deterministic approach, we show that the region of bistability increases in extent when the copy number of one of the genes is reduced from 2 to 1. The negative feedback loop has the effect of reducing the size of the bistable region. Loss of a gene copy, brought about by mutations, hampers the normal functioning of the β-cells giving rise to the genetic disorder, maturity-onset diabetes of the young (MODY). The diabetic phenotype makes its appearance when a sizable fraction of the β-cells is in the OFF state. Using stochastic simulation techniques we show that, on reduction of the gene copy number, there is a transition from the monostable ON to the ON state in the bistable region of the parameter space. Fluctuations in the protein levels, arising due to the stochastic nature of gene expression, can give rise to transitions between the ON and OFF states. We show that as the strength of autorepression increases, the ON → OFF state transitions become less probable whereas the reverse transitions are more probable. The implications of the results in the context of the occurrence of MODY are pointed out

  4. Functional characteristics of a double positive feedback loop coupled with autorepression

    Science.gov (United States)

    Banerjee, Subhasis; Bose, Indrani

    2008-12-01

    We study the functional characteristics of a two-gene motif consisting of a double positive feedback loop and an autoregulatory negative feedback loop. The motif appears in the gene regulatory network controlling the functional activity of pancreatic β-cells. The model exhibits bistability and hysteresis in appropriate parameter regions. The two stable steady states correspond to low (OFF state) and high (ON state) protein levels, respectively. Using a deterministic approach, we show that the region of bistability increases in extent when the copy number of one of the genes is reduced from 2 to 1. The negative feedback loop has the effect of reducing the size of the bistable region. Loss of a gene copy, brought about by mutations, hampers the normal functioning of the β-cells giving rise to the genetic disorder, maturity-onset diabetes of the young (MODY). The diabetic phenotype makes its appearance when a sizable fraction of the β-cells is in the OFF state. Using stochastic simulation techniques we show that, on reduction of the gene copy number, there is a transition from the monostable ON to the ON state in the bistable region of the parameter space. Fluctuations in the protein levels, arising due to the stochastic nature of gene expression, can give rise to transitions between the ON and OFF states. We show that as the strength of autorepression increases, the ON → OFF state transitions become less probable whereas the reverse transitions are more probable. The implications of the results in the context of the occurrence of MODY are pointed out.

  5. The Double Feedback Loop and the Parameter Theory of Text Genres

    DEFF Research Database (Denmark)

    Bundgaard, Peer; Østergaard, Svend

    2014-01-01

    on the first feedback loop: the way genres develop as deviations from existing text types and then stabilize as text types proper with a normative import. The second scope of this article consists in developing a typological apparatus consistent with the dynamic approach to the emergence of genres. This is our...... parameter theory of genres which is presented in Section 3. Here we consider genres as governed by parameters external to them and intrinsic to the situations they are dynamically related to. Genres should thus be understood not simply in terms of inherent textual or formal traits, but also relative...

  6. Analytically exploiting noise correlations inside the feedback loop to improve locked-oscillator performance

    CSIR Research Space (South Africa)

    Sastrawan, J

    2016-08-01

    Full Text Available (2016) Analytically exploiting noise correlations inside the feedback loop to improve locked-oscillator performance J. Sastrawan,1 C. Jones,1 I. Akhalwaya,2 H. Uys,2 and M. J. Biercuk1,* 1ARC Centre for Engineered Quantum Systems, School of Physics...) that probes and is locked to the atomic transition. The LO frequencymay evolve randomly in time due to intrinsic noise processes in the underlying hardware [10,11], leading to time-varying deviations of the LO frequency from that of the stable atomic reference...

  7. Controlling Unknown Saddle Type Steady States of Dynamical Systems with Latency in the Feedback Loop

    DEFF Research Database (Denmark)

    Tamasevicius, Arunas; Bumeliene, Skaidra; Tamaseviciute, Elena

    2009-01-01

    We suggest an adaptive control technique for stabilizing saddle type unstable steady states of dynamical systems. The controller is composed of an unstable and a stable high-pass filters operating in parallel. The mathematical model is considered analytically and numerically. The conjoint...... controller is sufficiently robust to time latencies in the feedback loop. In addition, it is not sensitive to the damping parameters of the system and is relatively fast. Experiments have been performed using a simplified version of the electronic Young-Silva circuit imitating behavior of the Duffing...

  8. Pulse oximeter improvement with an ADC-DAC feedback loop and a radial reflectance sensor.

    Science.gov (United States)

    Thompson, David; Wareing, Austin; Day, Dwight; Warren, Steve

    2006-01-01

    Pulse oximeter circuitry must meet several design constraints, including the ability to separate a small pulsatile signal component from a large signal baseline. This paper describes pulse oximeter design changes that produced order-of-magnitude improvements in signal quality. The primary changes were (a) the replacement of an analog sample-and-hold-based differentiator circuit with an ADC-DAC feedback loop and (b) the replacement of a side-by-side reflectance sensor design with a radial sensor arrangement that maximizes the pulsatile-to-baseline signal ratio.

  9. Designing Dialogic E-Learning in Pharmacy Professionalism Using Calibrated Feedback Loops (CFLs

    Directory of Open Access Journals (Sweden)

    Sue Roff

    2013-09-01

    Full Text Available The feedback analytics of online software including Articulate and Bristol Online Surveys can be used to facilitate dialogic learning in a community of practice such as Pharmacy and, thereby, promote reflective learning by the creation of formative calibrated feedback loops. Based on work with medical, dental, nursing, osteopathic, and social work students, trainees, and registrants, the paper shows how an online learning community can be created along the continuum from undergraduate to registrant to develop authentic dialogic e-learning around standards of Professionalism. The Dundee PolyProfessionalism inventories and Situational Judgement Scenarios (SJSs can be customised for Pharmacy Professionalism learning to support evidence-based curriculum design along benchmarked learning curves and to profile Professionalism learning in individuals and cohorts.

  10. The kinematics of the rigid feedback linkage, the impedance of the hydraulic servomechanism and the flutter occurrence

    Directory of Open Access Journals (Sweden)

    Ioan URSU

    2012-09-01

    Full Text Available The paper brought to light a previous result of the author, used in the design of hydraulicservos actuating flight controls of the airplanes IAR 93 and IAR 99. The results highlights theimportance of the the kinematics of the rigid feedback linkage of the hydraulic servo in anaeroservoelastic frame.

  11. Stress-specific response of the p53-Mdm2 feedback loop

    Directory of Open Access Journals (Sweden)

    Jensen Mogens H

    2010-07-01

    Full Text Available Abstract Background The p53 signalling pathway has hundreds of inputs and outputs. It can trigger cellular senescence, cell-cycle arrest and apoptosis in response to diverse stress conditions, including DNA damage, hypoxia and nutrient deprivation. Signals from all these inputs are channeled through a single node, the transcription factor p53. Yet, the pathway is flexible enough to produce different downstream gene expression patterns in response to different stresses. Results We construct a mathematical model of the negative feedback loop involving p53 and its inhibitor, Mdm2, at the core of this pathway, and use it to examine the effect of different stresses that trigger p53. In response to DNA damage, hypoxia, etc., the model exhibits a wide variety of specific output behaviour - steady states with low or high levels of p53 and Mdm2, as well as spiky oscillations with low or high average p53 levels. Conclusions We show that even a simple negative feedback loop is capable of exhibiting the kind of flexible stress-specific response observed in the p53 system. Further, our model provides a framework for predicting the differences in p53 response to different stresses and single nucleotide polymorphisms.

  12. Power flow control based solely on slow feedback loop for heart pump applications.

    Science.gov (United States)

    Wang, Bob; Hu, Aiguo Patrick; Budgett, David

    2012-06-01

    This paper proposes a new control method for regulating power flow via transcutaneous energy transfer (TET) for implantable heart pumps. Previous work on power flow controller requires a fast feedback loop that needs additional switching devices and resonant capacitors to be added to the primary converter. The proposed power flow controller eliminates these additional components, and it relies solely on a slow feedback loop to directly drive the primary converter to meet the heart pump power demand and ensure zero voltage switching. A controlled change in switching frequency varies the resonant tank shorting period of a current-fed push-pull resonant converter, thus changing the magnitude of the primary resonant voltage, as well as the tuning between primary and secondary resonant tanks. The proposed controller has been implemented successfully using an analogue circuit and has reached an end-to-end power efficiency of 79.6% at 10 W with a switching frequency regulation range of 149.3 kHz to 182.2 kHz.

  13. Interaction between beam control and rf feedback loops for high Q cavities an heavy beam loading. Revision A

    International Nuclear Information System (INIS)

    Mestha, L.K.; Kwan, C.M.; Yeung, K.S.

    1994-04-01

    An open-loop state space model of all the major low-level rf feedback control loops is derived. The model has control and state variables for fast-cycling machines to apply modern multivariable feedback techniques. A condition is derived to know when exactly we can cross the boundaries between time-varying and time-invariant approaches for a fast-cycling machine like the Low Energy Booster (LEB). The conditions are dependent on the Q of the cavity and the rate at which the frequency changes with time. Apart from capturing the time-variant characteristics, the errors in the magnetic field are accounted in the model to study the effects on synchronization with the Medium Energy Booster (MEB). The control model is useful to study the effects on beam control due to heavy beam loading at high intensities, voltage transients just after injection especially due to time-varying voltages, instability thresholds created by the cavity tuning feedback system, cross coupling between feedback loops with and without direct rf feedback etc. As a special case we have shown that the model agrees with the well known Pedersen model derived for the CERN PS booster. As an application of the model we undertook a detailed study of the cross coupling between the loops by considering all of them at once for varying time, Q and beam intensities. A discussion of the method to identify the coupling is shown. At the end a summary of the identified loop interactions is presented

  14. Study of an accelerating superconducting module and its feedback loop systems for the MYRRHA project

    International Nuclear Information System (INIS)

    Bouly, F.

    2011-11-01

    The MYRRHA ( Multi-purpose hybrid Research Reactor for High-tech Applications ) project aims at constructing an accelerator driven system (ADS) demonstrator (50 a 100 MWth) to explore the feasibility of nuclear waste transmutation. Such a subcritical reactor requires an extremely reliable accelerator which delivers a CW high power protons beam (600 MeV, 4 mA). The reference solution for this machine is a superconducting linear accelerator. This thesis presents the work - undertaken at IPN Orsay in October 2008 - on the study of a prototypical superconducting module and the feedback control systems of its cavity for the high energy part of the MYRRHA linac. First, the optimization and the design of 5-cell elliptical cavities (β=0,65), operating at 704.4 MHz, are presented. Then, the experimental work focuses on a reliability oriented study of the 'cryo-module' which hold a prototypical 5-cell cavity (β=0,47). In this study, the dynamic behavior of the fast tuning system of the cavity was measured and qualified. The 'field flatness' issue in 'low beta' multi-cell cavity was also brought to light. Finally, a fault-tolerance analysis of the linac was carried out. Toward this goal, a model of the cavity, its RF feedback loop system and its tuning system feedback loop was developed. This study enabled to determine the RF power needs, the tuning system requirements and as well as to demonstrate the feasibility of fast fault-recovery scenarios to minimize the number of beam interruptions in the MYRRHA linac. (author)

  15. Quality-factor amplification in piezoelectric MEMS resonators applying an all-electrical feedback loop

    International Nuclear Information System (INIS)

    Manzaneque, T; Hernando-García, J; Sánchez-Rojas, J L; Ababneh, A; Schwarz, P; Seidel, H; Schmid, U

    2011-01-01

    An all-electrical velocity feedback control to enhance the quality factor of piezoelectric aluminium nitride (AlN)-based microcantilevers and microbridges was implemented. Two alternatives to obtain a velocity-proportional signal were demonstrated depending on the top electrode configuration. For a straightforward electrode design in one-port configuration (i.e. self-actuation and self-sensing), a velocity signal, proportional to the piezoelectric current, was used in the feedback loop by cancelling out the dielectric current electronically. For top electrodes allowing a two-port configuration (i.e. one for actuation and one for sensing), the piezoelectric current is directly extracted and its relationship with velocity is analysed taking the symmetry of the modal shape into account. Standard operational amplifier-based configurations for the feedback circuits were implemented on a printed circuit board. Quality factors were determined from the transient electrical response of the devices. Comparable results were obtained from the displacement spectrum applying a laser Doppler vibrometer. Quality factors as high as 2 × 10 5 , corresponding to an enhancement factor of about 200, were achieved in air for the lowest gain margin achievable before the circuit becomes unstable, making this kind of device more competitive for mass sensor applications due to enhanced spectral resolution.

  16. Asymmetric dual-loop feedback to suppress spurious tones and reduce timing jitter in self-mode-locked quantum-dash lasers emitting at 155 μm

    Science.gov (United States)

    Asghar, Haroon; McInerney, John G.

    2017-09-01

    We demonstrate an asymmetric dual-loop feedback scheme to suppress external cavity side-modes induced in self-mode-locked quantum-dash lasers with conventional single and dual-loop feedback. In this letter, we achieved optimal suppression of spurious tones by optimizing the length of second delay time. We observed that asymmetric dual-loop feedback, with large (~8x) disparity in cavity lengths, eliminates all external-cavity side-modes and produces flat RF spectra close to the main peak with low timing jitter compared to single-loop feedback. Significant reduction in RF linewidth and reduced timing jitter was also observed as a function of increased second feedback delay time. The experimental results based on this feedback configuration validate predictions of recently published numerical simulations. This interesting asymmetric dual-loop feedback scheme provides simplest, efficient and cost effective stabilization of side-band free optoelectronic oscillators based on mode-locked lasers.

  17. Quasi-open loop hydraulic ram incremental actuator with power conserving properties

    International Nuclear Information System (INIS)

    Raymond, E.T.; Robinson, C.W.

    1982-01-01

    An electric stepping motor, operated by command signals from a computer or a microprocessor, rotates a rotary control member of a distributor valve, for sequencing hydraulic pressure and hence flow to the cylinders of an axial piston hydraulic machine. A group of the cylinders are subjected to pressure and flow and the remaining cylinders are vented to a return line. Rotation of the rotary control valve member sequences pressurization by progressively adding a cylinder to the forward edge to the pressurized group and removing a cylinder from the trailing edge of the pressurized group. The double ended pistons of each new pressurized group function to drive a wobble plate into a new position of equilibrium and then hold it in such position until another change in the makeup of the pressurized group. These pistons also displace hydraulic fluid from the opposite cylinder head which serves as the output of a pumping element. An increment of displacement of the wobble plate occurs in direct response to each command pulse that is received by the stepping motor. Wobble plate displacement drives the rotary valve of the hydraulic power transfer unit, causing it to transfer hydraulic fluid from a first expansible chamber on one side of a piston in a hydraulic ram to a second expansible chamber on the opposite side of the piston. Reverse drive of the hydraulic power transfer unit reverses the direction of transfer of hydraulic fluid between the two expansible chambers

  18. An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma

    Science.gov (United States)

    Drier, Yotam; Cotton, Matthew J.; Williamson, Kaylyn E.; Gillespie, Shawn M.; Ryan, Russell J.H.; Kluk, Michael J.; Carey, Christopher D.; Rodig, Scott J.; Sholl, Lynette M; Afrogheh, Amir H.; Faquin, William C.; Queimado, Lurdes; Qi, Jun; Wick, Michael J.; El-Naggar, Adel K.; Bradner, James E.; Moskaluk, Christopher A.; Aster, Jon C.; Knoechel, Birgit; Bernstein, Bradley E.

    2016-01-01

    Translocation events are frequent in cancer and may create chimeric fusions or ‘regulatory rearrangements’ that drive oncogene overexpression. Here we identify super-enhancer translocations that drive overexpression of the oncogenic transcription factor MYB as a recurrent theme in adenoid cystic carcinoma (ACC). Whole-genome sequencing data and chromatin maps reveal distinct chromosomal rearrangements that juxtapose super-enhancers to the MYB locus. Chromosome conformation capture confirms that the translocated enhancers interact with the MYB promoter. Remarkably, MYB protein binds to the translocated enhancers, creating a positive feedback loop that sustains its expression. MYB also binds enhancers that drive different regulatory programs in alternate cell lineages in ACC, cooperating with TP63 in myoepithelial cells and a Notch program in luminal epithelial cells. Bromodomain inhibitors slow tumor growth in ACC primagraft models in vivo. Thus, our study identifies super-enhancer translocations that drive MYB expression and provides insight into downstream MYB functions in the alternate ACC lineages. PMID:26829750

  19. Feedback loops and temporal misalignment in component-based hydrologic modeling

    Science.gov (United States)

    Elag, Mostafa M.; Goodall, Jonathan L.; Castronova, Anthony M.

    2011-12-01

    In component-based modeling, a complex system is represented as a series of loosely integrated components with defined interfaces and data exchanges that allow the components to be coupled together through shared boundary conditions. Although the component-based paradigm is commonly used in software engineering, it has only recently been applied for modeling hydrologic and earth systems. As a result, research is needed to test and verify the applicability of the approach for modeling hydrologic systems. The objective of this work was therefore to investigate two aspects of using component-based software architecture for hydrologic modeling: (1) simulation of feedback loops between components that share a boundary condition and (2) data transfers between temporally misaligned model components. We investigated these topics using a simple case study where diffusion of mass is modeled across a water-sediment interface. We simulated the multimedia system using two model components, one for the water and one for the sediment, coupled using the Open Modeling Interface (OpenMI) standard. The results were compared with a more conventional numerical approach for solving the system where the domain is represented by a single multidimensional array. Results showed that the component-based approach was able to produce the same results obtained with the more conventional numerical approach. When the two components were temporally misaligned, we explored the use of different interpolation schemes to minimize mass balance error within the coupled system. The outcome of this work provides evidence that component-based modeling can be used to simulate complicated feedback loops between systems and guidance as to how different interpolation schemes minimize mass balance error introduced when components are temporally misaligned.

  20. Design and control of a point absorber wave energy converter with an open loop hydraulic transmission

    International Nuclear Information System (INIS)

    Fan, YaJun; Mu, AnLe; Ma, Tao

    2016-01-01

    Highlights: • Point absorber wave energy converter is presented. • Piston pump module captures and converts wave energy. • Hydraulic accumulator stores/releases the surplus energy. • Fuzzy controller adjusts the displacement of hydraulic motor. • Generator outputs meet the electricity demand precisely. - Abstract: In this paper, a point absorber wave energy converter combined with offshore wind turbine is proposed. In the system, the wave energy is captured and converted into hydraulic energy by a piston pump module, which is combined with a wind turbine floating platform, and then the hydraulic energy is converted into electricity energy by a variable displacement hydraulic motor and induction generator. In order to smooth and stabilize the captured wave energy, a hydraulic accumulator is applied to store and release the excess energy. In order to meet the demand power a fuzzy controller is designed to adjust the displacement of hydraulic motor and controlled the output power. Simulation under irregular wave condition has been carried out to verify the validity of the mathematical model and the effectiveness of the controller strategy. The results show that the wave energy converter system could deliver the required electricity power precisely as the motor output torque is controlled. The accumulator could damp out all the fluctuations in output power, so the wave energy would become a dispatchable power source.

  1. Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing.

    Science.gov (United States)

    Soenksen, L R; Kassis, T; Noh, M; Griffith, L G; Trumper, D L

    2018-03-13

    Precise fluid height sensing in open-channel microfluidics has long been a desirable feature for a wide range of applications. However, performing accurate measurements of the fluid level in small-scale reservoirs (sensor contact needs to be avoided. In particular, gravity-driven systems used in several microfluidic applications to establish pressure gradients and impose flow remain open-loop and largely unmonitored due to these sensing limitations. Here we present an optimized self-shielded coplanar capacitive sensor design and automated control system to provide submillimeter fluid-height resolution (∼250 μm) and control of small-scale open reservoirs without the need for direct fluid contact. Results from testing and validation of our optimized sensor and system also suggest that accurate fluid height information can be used to robustly characterize, calibrate and dynamically control a range of microfluidic systems with complex pumping mechanisms, even in cell culture conditions. Capacitive sensing technology provides a scalable and cost-effective way to enable continuous monitoring and closed-loop feedback control of fluid volumes in small-scale gravity-dominated wells in a variety of microfluidic applications.

  2. Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells.

    Science.gov (United States)

    Morita, Ken; Noura, Mina; Tokushige, Chieko; Maeda, Shintaro; Kiyose, Hiroki; Kashiwazaki, Gengo; Taniguchi, Junichi; Bando, Toshikazu; Yoshida, Kenichi; Ozaki, Toshifumi; Matsuo, Hidemasa; Ogawa, Seishi; Liu, Pu Paul; Nakahata, Tatsutoshi; Sugiyama, Hiroshi; Adachi, Souichi; Kamikubo, Yasuhiko

    2017-11-30

    Although runt-related transcription factor 1 (RUNX1) and its associating core binding factor-β (CBFB) play pivotal roles in leukemogenesis, and inhibition of RUNX1 has now been widely recognized as a novel strategy for anti-leukemic therapies, it has been elusive how leukemic cells could acquire the serious resistance against RUNX1-inhibition therapies and also whether CBFB could participate in this process. Here, we show evidence that p53 (TP53) and CBFB are sequentially up-regulated in response to RUNX1 depletion, and their mutual interaction causes the physiological resistance against chemotherapy for acute myeloid leukemia (AML) cells. Mechanistically, p53 induced by RUNX1 gene silencing directly binds to CBFB promoter and stimulates its transcription as well as its translation, which in turn acts as a platform for the stabilization of RUNX1, thereby creating a compensative RUNX1-p53-CBFB feedback loop. Indeed, AML cells derived from relapsed cases exhibited higher CBFB expression levels compared to those from primary AML cells at diagnosis, and these CBFB expressions were positively correlated to those of p53. Our present results underscore the importance of RUNX1-p53-CBFB regulatory loop in the development and/or maintenance of AML cells, which could be targeted at any sides of this triangle in strategizing anti-leukemia therapies.

  3. Comparison of thermo-hydraulic analysis with measurements for HELIOS. The scaled integral test loop for PEACER

    International Nuclear Information System (INIS)

    Cho, Jae Hyun; Lim, Jun; Kim, Ji Hak; Hwang, Il Soon

    2009-01-01

    A scaled-down Lead-Bismuth Eutectic circulating integral test loop named as HELIOS (Heavy Eutectic liquid metal Loop for Integral test of Operability and Safety of PEACER) has been employed to characterize steady-state isothermal forced circulation behavior and non-isothermal natural circulation capability of the lead and lead-alloy cooled advanced nuclear energy systems (LACANES). In this time, thermal-hydraulic experiments have been carried out using HELIOS following rigorous calibration campaigns on sensors for temperature and pressure, especially isothermal steady-state forced convection using by the pump. The isothermal steady-state forced convection test was performed to obtain the pressure loss information including friction loss coefficients and form loss coefficients. Then its data were compared with multi-approaching analysis including hand calculation results and computer simulation code results. (MARS-LBE, CFX). We report the results of comparisons between the analysis and measurements together. (author)

  4. A new discrete dynamic model of ABA-induced stomatal closure predicts key feedback loops.

    Directory of Open Access Journals (Sweden)

    Réka Albert

    2017-09-01

    several predictions of the model with regard to reactive oxygen species, cytosolic Ca2+ (Ca2+c, and heterotrimeric G-protein signaling. We analyzed dynamics-determining positive and negative feedback loops, thereby elucidating the attractor (dynamic behavior repertoire of the system and the groups of nodes that determine each attractor. Based on this analysis, we predict the likely presence of a previously unrecognized feedback mechanism dependent on Ca2+c. This mechanism would provide model agreement with 10 additional experimental observations, for a validation rate of 85%. Our research underscores the importance of feedback regulation in generating robust and adaptable biological responses. The high validation rate of our model illustrates the advantages of discrete dynamic modeling for complex, nonlinear systems common in biology.

  5. A new discrete dynamic model of ABA-induced stomatal closure predicts key feedback loops.

    Science.gov (United States)

    Albert, Réka; Acharya, Biswa R; Jeon, Byeong Wook; Zañudo, Jorge G T; Zhu, Mengmeng; Osman, Karim; Assmann, Sarah M

    2017-09-01

    of the model with regard to reactive oxygen species, cytosolic Ca2+ (Ca2+c), and heterotrimeric G-protein signaling. We analyzed dynamics-determining positive and negative feedback loops, thereby elucidating the attractor (dynamic behavior) repertoire of the system and the groups of nodes that determine each attractor. Based on this analysis, we predict the likely presence of a previously unrecognized feedback mechanism dependent on Ca2+c. This mechanism would provide model agreement with 10 additional experimental observations, for a validation rate of 85%. Our research underscores the importance of feedback regulation in generating robust and adaptable biological responses. The high validation rate of our model illustrates the advantages of discrete dynamic modeling for complex, nonlinear systems common in biology.

  6. A computational model clarifies the roles of positive and negative feedback loops in the Drosophila circadian clock

    Energy Technology Data Exchange (ETDEWEB)

    Wang Junwei, E-mail: wangjunweilj@yahoo.com.c [Cisco School of Informatics, Guangdong University of Foreign Studies, Guangzhou 510006 (China); Zhou Tianshou [School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275 (China)

    2010-06-14

    Previous studies showed that a single negative feedback structure should be sufficient for robust circadian oscillations. It is thus pertinent to ask why current cellular clock models almost universally have interlocked negative feedback loop (NFL) and positive feedback loop (PFL). Here, we propose a molecular model that reflects the essential features of the Drosophila circadian clock to clarify the different roles of negative and positive feedback loops. In agreement with experimental observations, the model can simulate circadian oscillations in constant darkness, entrainment by light-dark cycles, as well as phenotypes of per{sup 01} and clk{sup Jrk} mutants. Moreover, sustained oscillations persist when the PFL is removed, implying the crucial role of NFL for rhythm generation. Through parameter sensitivity analysis, it is revealed that incorporation of PFL increases the robustness of the system to regulatory processes in PFL itself. Such reduced models can aid understanding of the design principles of circadian clocks in Drosophila and other organisms with complex transcriptional feedback structures.

  7. The model of the thermal and hydraulic behaviour of a out-of-pile test loop; Model thermohidraulickog ponasanja vanreaktorskog exksperimentalnog cirkulacionog kola

    Energy Technology Data Exchange (ETDEWEB)

    Vehauc, A; Stosic, Z [Institut za nuklearne nauke Boris Kidric, Voinca, Belgrade (Yugoslavia)

    1988-07-01

    A complex circulation loop was modeled and a simulation program developed for the determination of the pressure, temperature, velocity and flow rate distribution in legs of the loop. The model was used to study the thermal and hydraulic behaviour of an out-of-pile test loop at IBK-ITE. For a given set of conditions in the test section, the model yields data on all the operating modes possible with the existing control system and in consequence on the optimum operating conditions for the loop as a whole. (author)

  8. Peatland plant communities under global change: negative feedback loops counteract shifts in species composition.

    Science.gov (United States)

    Hedwall, Per-Ola; Brunet, Jörg; Rydin, Håkan

    2017-01-01

    Mires (bogs and fens) are nutrient-limited peatland ecosystems, the vegetation of which is especially sensitive to nitrogen deposition and climate change. The role of mires in the global carbon cycle, and the delivery of different ecosystem services can be considerably altered by changes in the vegetation, which has a strong impact on peat-formation and hydrology. Mire ecosystems are commonly open with limited canopy cover but both nitrogen deposition and increased temperatures may increase the woody vegetation component. It has been predicted that such an increase in tree cover and the associated effects on light and water regimes would cause a positive feed-back loop with respect to the ground vegetation. None of these effects, however, have so far been confirmed in large-scale spatiotemporal studies. Here we analyzed data pertaining to mire vegetation from the Swedish National Forest Inventory collected from permanent sample plots over a period of 20 yr along a latitudinal gradient covering 14°. We hypothesized that the changes would be larger in the southern parts as a result of higher nitrogen deposition and warmer climate. Our results showed an increase in woody vegetation with increases in most ericaceous dwarf-shrubs and in the basal area of trees. These changes were, in contrast to our expectations, evenly distributed over most of the latitudinal gradient. While nitrogen deposition is elevated in the south, the increase in temperatures during recent decades has been larger in the north. Hence, we suggest that different processes in the north and south have produced similar vegetation changes along the latitudinal gradient. There was, however, a sharp increase in compositional change at high deposition, indicating a threshold effect in the response. Instead of a positive feed-back loop caused by the tree layer, an increase in canopy cover reduced the changes in composition of the ground vegetation, whereas a decrease in canopy cover lead to larger changes

  9. A review of modern advances in analyses and applications of single-phase natural circulation loop in nuclear thermal hydraulics

    International Nuclear Information System (INIS)

    Basu, Dipankar N.; Bhattacharyya, Souvik; Das, P.K.

    2014-01-01

    Highlights: • Comprehensive review of state-of-the-art on single-phase natural circulation loops. • Detailed discussion on growth in solar thermal system and nuclear thermal hydraulics. • Systematic development in scaling methodologies for fabrication of test facilities. • Importance of numerical modeling schemes for stability assessment using 1-D codes. • Appraisal of current trend of research and possible future directions. - Abstract: A comprehensive review of single-phase natural circulation loop (NCL) is presented here. Relevant literature reported since the later part of 1980s has been meticulously surveyed, with occasional obligatory reference to a few pioneering studies originating prior to that period, summarizing the key observations and the present trend of research. Development in the concept of buoyancy-induced flow is discussed, with introduction to flow initiation in an NCL due to instability. Detailed discussion on modern advancement in important application areas like solar thermal systems and nuclear thermal hydraulics are presented, with separate analysis for various reactor designs working on natural circulation. Identification of scaling criteria for designing lab-scale experimental facilities has gone through a series of modification. A systematic analysis of the same is presented, considering the state-of-the-art knowledge base. Different approaches have been followed for modeling single-phase NCLs, including simplified Lorenz system mostly for toroidal loops, 1-D computational modeling for both steady-state and stability characterization and 3-D commercial system codes to have a better flow visualization. Methodical review of the relevant studies is presented following a systematic approach, to assess the gradual progression in understanding of the practical system. Brief appraisal of current research interest is reported, including the use of nanofluids for fluid property augmentation, marine reactors subjected to rolling waves

  10. A review of modern advances in analyses and applications of single-phase natural circulation loop in nuclear thermal hydraulics

    Energy Technology Data Exchange (ETDEWEB)

    Basu, Dipankar N., E-mail: dipankar.n.basu@gmail.com [Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati 781039 (India); Bhattacharyya, Souvik; Das, P.K. [Department of Mechanical Engineering, Indian Institute of Technology Kharagpur, Kharagpur 721302 (India)

    2014-12-15

    Highlights: • Comprehensive review of state-of-the-art on single-phase natural circulation loops. • Detailed discussion on growth in solar thermal system and nuclear thermal hydraulics. • Systematic development in scaling methodologies for fabrication of test facilities. • Importance of numerical modeling schemes for stability assessment using 1-D codes. • Appraisal of current trend of research and possible future directions. - Abstract: A comprehensive review of single-phase natural circulation loop (NCL) is presented here. Relevant literature reported since the later part of 1980s has been meticulously surveyed, with occasional obligatory reference to a few pioneering studies originating prior to that period, summarizing the key observations and the present trend of research. Development in the concept of buoyancy-induced flow is discussed, with introduction to flow initiation in an NCL due to instability. Detailed discussion on modern advancement in important application areas like solar thermal systems and nuclear thermal hydraulics are presented, with separate analysis for various reactor designs working on natural circulation. Identification of scaling criteria for designing lab-scale experimental facilities has gone through a series of modification. A systematic analysis of the same is presented, considering the state-of-the-art knowledge base. Different approaches have been followed for modeling single-phase NCLs, including simplified Lorenz system mostly for toroidal loops, 1-D computational modeling for both steady-state and stability characterization and 3-D commercial system codes to have a better flow visualization. Methodical review of the relevant studies is presented following a systematic approach, to assess the gradual progression in understanding of the practical system. Brief appraisal of current research interest is reported, including the use of nanofluids for fluid property augmentation, marine reactors subjected to rolling waves

  11. The time-dependent 3D discrete ordinates code TORT-TD with thermal-hydraulic feedback by ATHLET models

    International Nuclear Information System (INIS)

    Seubert, A.; Velkov, K.; Langenbuch, S.

    2008-01-01

    This paper describes the time-dependent 3D discrete ordinates transport code TORT-TD. Thermal-hydraulic feedback is considered by coupling TORT-TD with the thermal-hydraulics system code ATHLET. The coupled code TORT-TD/ATHLET allows 3D pin-by-pin analyses of transients in few energy groups and anisotropic scattering by solving the time-dependent transport equation using the unconditionally stable implicit method. The nuclear cross sections are interpolated between pre-calculated table values of fuel temperature, moderator density and boron concentration. For verification of the implementation, selected test cases have been calculated by TORT-TD/ATHLET. They include a control rod ejection transient in a small PWR fuel assembly arrangement and a local boron concentration change in a single PWR fuel assembly. In the latter, special attention has been paid to study the influence of the thermal-hydraulic feedback modelling in ATHLET. The results obtained for a control rod ejection accident in a PWR quarter core demonstrate the applicability of TORT-TD/ATHLET. (authors)

  12. Online Reconstruction and Calibration with Feedback Loop in the ALICE High Level Trigger

    Directory of Open Access Journals (Sweden)

    Rohr David

    2016-01-01

    at the Large Hadron Collider (LHC at CERN. The High Level Trigger (HLT is an online computing farm, which reconstructs events recorded by the ALICE detector in real-time. The most computing-intensive task is the reconstruction of the particle trajectories. The main tracking devices in ALICE are the Time Projection Chamber (TPC and the Inner Tracking System (ITS. The HLT uses a fast GPU-accelerated algorithm for the TPC tracking based on the Cellular Automaton principle and the Kalman filter. ALICE employs gaseous subdetectors which are sensitive to environmental conditions such as ambient pressure and temperature and the TPC is one of these. A precise reconstruction of particle trajectories requires the calibration of these detectors. As our first topic, we present some recent optimizations to our GPU-based TPC tracking using the new GPU models we employ for the ongoing and upcoming data taking period at LHC. We also show our new approach to fast ITS standalone tracking. As our second topic, we present improvements to the HLT for facilitating online reconstruction including a new flat data model and a new data flow chain. The calibration output is fed back to the reconstruction components of the HLT via a feedback loop. We conclude with an analysis of a first online calibration test under real conditions during the Pb-Pb run in November 2015, which was based on these new features.

  13. Parallel arrangements of positive feedback loops limit cell-to-cell variability in differentiation.

    Directory of Open Access Journals (Sweden)

    Anupam Dey

    Full Text Available Cellular differentiations are often regulated by bistable switches resulting from specific arrangements of multiple positive feedback loops (PFL fused to one another. Although bistability generates digital responses at the cellular level, stochasticity in chemical reactions causes population heterogeneity in terms of its differentiated states. We hypothesized that the specific arrangements of PFLs may have evolved to minimize the cellular heterogeneity in differentiation. In order to test this we investigated variability in cellular differentiation controlled either by parallel or serial arrangements of multiple PFLs having similar average properties under extrinsic and intrinsic noises. We find that motifs with PFLs fused in parallel to one another around a central regulator are less susceptible to noise as compared to the motifs with PFLs arranged serially. Our calculations suggest that the increased resistance to noise in parallel motifs originate from the less sensitivity of bifurcation points to the extrinsic noise. Whereas estimation of mean residence times indicate that stable branches of bifurcations are robust to intrinsic noise in parallel motifs as compared to serial motifs. Model conclusions are consistent both in AND- and OR-gate input signal configurations and also with two different modeling strategies. Our investigations provide some insight into recent findings that differentiation of preadipocyte to mature adipocyte is controlled by network of parallel PFLs.

  14. Parallel arrangements of positive feedback loops limit cell-to-cell variability in differentiation.

    Science.gov (United States)

    Dey, Anupam; Barik, Debashis

    2017-01-01

    Cellular differentiations are often regulated by bistable switches resulting from specific arrangements of multiple positive feedback loops (PFL) fused to one another. Although bistability generates digital responses at the cellular level, stochasticity in chemical reactions causes population heterogeneity in terms of its differentiated states. We hypothesized that the specific arrangements of PFLs may have evolved to minimize the cellular heterogeneity in differentiation. In order to test this we investigated variability in cellular differentiation controlled either by parallel or serial arrangements of multiple PFLs having similar average properties under extrinsic and intrinsic noises. We find that motifs with PFLs fused in parallel to one another around a central regulator are less susceptible to noise as compared to the motifs with PFLs arranged serially. Our calculations suggest that the increased resistance to noise in parallel motifs originate from the less sensitivity of bifurcation points to the extrinsic noise. Whereas estimation of mean residence times indicate that stable branches of bifurcations are robust to intrinsic noise in parallel motifs as compared to serial motifs. Model conclusions are consistent both in AND- and OR-gate input signal configurations and also with two different modeling strategies. Our investigations provide some insight into recent findings that differentiation of preadipocyte to mature adipocyte is controlled by network of parallel PFLs.

  15. An Actomyosin-Arf-GEF Negative Feedback Loop for Tissue Elongation under Stress.

    Science.gov (United States)

    West, Junior J; Zulueta-Coarasa, Teresa; Maier, Janna A; Lee, Donghoon M; Bruce, Ashley E E; Fernandez-Gonzalez, Rodrigo; Harris, Tony J C

    2017-08-07

    In response to a pulling force, a material can elongate, hold fast, or fracture. During animal development, multi-cellular contraction of one region often stretches neighboring tissue. Such local contraction occurs by induced actomyosin activity, but molecular mechanisms are unknown for regulating the physical properties of connected tissue for elongation under stress. We show that cytohesins, and their Arf small G protein guanine nucleotide exchange activity, are required for tissues to elongate under stress during both Drosophila dorsal closure (DC) and zebrafish epiboly. In Drosophila, protein localization, laser ablation, and genetic interaction studies indicate that the cytohesin Steppke reduces tissue tension by inhibiting actomyosin activity at adherens junctions. Without Steppke, embryogenesis fails, with epidermal distortions and tears resulting from myosin misregulation. Remarkably, actomyosin network assembly is necessary and sufficient for local Steppke accumulation, where live imaging shows Steppke recruitment within minutes. This rapid negative feedback loop provides a molecular mechanism for attenuating the main tension generator of animal tissues. Such attenuation relaxes tissues and allows orderly elongation under stress. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Supporting graduate nurse transition to practice through a quality assurance feedback loop.

    Science.gov (United States)

    Phillips, Craig; Kenny, Amanda; Esterman, Adrian

    2017-11-01

    This mixed-method study focused on new graduate nurses and their transition to practice. Transition to practice can be a time of heightened stress and anxiety, leaving many new graduates disillusioned and dissatisfied with their work. The study explored how satisfaction levels with transition may improve during their first year, using a unique approach of a continuous quality assurance feedback loop. This assurance framework is utilised in hospitality, automotive and supply chain logistics and in health, primarily to monitor patient outcomes. However, an association with graduate nurse satisfaction has not been previously reported. Graduate nurses from two health services completed a short survey questionnaire every four weeks for 12 months. De-identified aggregated data was sent to health service management, giving them an opportunity to integrate the findings with the objective of potentially increasing graduate satisfaction ratings. Quantitative findings showed no statistical significance of graduate nurse satisfaction scores between health services, however, one health service consistently outperformed the other. Qualitative findings drawn from a seminar and interviews confirmed that one health service took a more proactive stance with the monthly reports, communicating the results to ward managers. Outcomes reflected a greater commitment of support and an overall increase of satisfaction scores. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. A Negative Feedback Loop Between Autophagy and Immune Responses in Mycobacterium leprae Infection.

    Science.gov (United States)

    Ma, Yuelong; Zhang, Li; Lu, Jie; Shui, Tiejun; Chen, Jia; Yang, Jun; Yuan, Joanna; Liu, Yeqiang; Yang, Degang

    2017-01-01

    The obligate intracellular bacterium Mycobacterium leprae is the causative agent of leprosy and primarily infects macrophages, leading to irreversible nerve damage and deformities. So far, the underlying reasons allowing M. leprae to persist and propagate in macrophages, despite the presence of cellular immunity, are still a mystery. Here, we investigated the role of autophagy, a cellular process that degrades cytosolic materials and intracellular pathogens, in M. leprae infection. We found that live M. leprae infection of macrophages resulted in significantly elevated autophagy level. However, macrophages with high autophagy levels preferentially expressed lower levels of proinflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-12, and tumor necrosis factor-α, and preferentially primed anti-inflammatory T cells responses, characterized by high IL-10 and low interferon-γ, granzyme B, and perforin responses. These anti-inflammatory T cells could suppress further induction of autophagy, leading to improved survival of intracellular M. leprae in infected macrophages. Therefore, these data demonstrated that although autophagy had a role in eliminating intracellular pathogens, the induction of autophagy resulted in anti-inflammatory immune responses, which suppressed autophagy in a negative feedback loop and allowed the persistence of M. leprae.

  18. Engineering the on-axis intensity of Bessel beam by a feedback tuning loop

    Science.gov (United States)

    Li, Runze; Yu, Xianghua; Yang, Yanlong; Peng, Tong; Yao, Baoli; Zhang, Chunmin; Ye, Tong

    2018-02-01

    The Bessel beam belongs to a typical class of non-diffractive optical fields that are characterized by their invariant focal profiles along the propagation direction. However, ideal Bessel beams only rigorously exist in theory; Bessel beams generated in the lab are quasi-Bessel beams with finite focal extensions and varying intensity profiles along the propagation axis. The ability to engineer the on-axis intensity profile to the desired shape is essential for many applications. Here we demonstrate an iterative optimization-based approach to engineering the on-axis intensity of Bessel beams. The genetic algorithm is used to demonstrate this approach. Starting with a traditional axicon phase mask, in the design process, the computed on-axis beam profile is fed into a feedback tuning loop of an iterative optimization process, which searches for an optimal radial phase distribution that can generate a generalized Bessel beam with the desired onaxis intensity profile. The experimental implementation involves a fine-tuning process that adjusts the originally targeted profile so that the optimization process can optimize the phase mask to yield an improved on-axis profile. Our proposed method has been demonstrated in engineering several zeroth-order Bessel beams with customized on-axis profiles. High accuracy and high energy throughput merit its use in many applications.

  19. A theory of how active behavior stabilises neural activity: Neural gain modulation by closed-loop environmental feedback.

    Directory of Open Access Journals (Sweden)

    Christopher L Buckley

    2018-01-01

    Full Text Available During active behaviours like running, swimming, whisking or sniffing, motor actions shape sensory input and sensory percepts guide future motor commands. Ongoing cycles of sensory and motor processing constitute a closed-loop feedback system which is central to motor control and, it has been argued, for perceptual processes. This closed-loop feedback is mediated by brainwide neural circuits but how the presence of feedback signals impacts on the dynamics and function of neurons is not well understood. Here we present a simple theory suggesting that closed-loop feedback between the brain/body/environment can modulate neural gain and, consequently, change endogenous neural fluctuations and responses to sensory input. We support this theory with modeling and data analysis in two vertebrate systems. First, in a model of rodent whisking we show that negative feedback mediated by whisking vibrissa can suppress coherent neural fluctuations and neural responses to sensory input in the barrel cortex. We argue this suppression provides an appealing account of a brain state transition (a marked change in global brain activity coincident with the onset of whisking in rodents. Moreover, this mechanism suggests a novel signal detection mechanism that selectively accentuates active, rather than passive, whisker touch signals. This mechanism is consistent with a predictive coding strategy that is sensitive to the consequences of motor actions rather than the difference between the predicted and actual sensory input. We further support the theory by re-analysing previously published two-photon data recorded in zebrafish larvae performing closed-loop optomotor behaviour in a virtual swim simulator. We show, as predicted by this theory, that the degree to which each cell contributes in linking sensory and motor signals well explains how much its neural fluctuations are suppressed by closed-loop optomotor behaviour. More generally we argue that our results

  20. A theory of how active behavior stabilises neural activity: Neural gain modulation by closed-loop environmental feedback.

    Science.gov (United States)

    Buckley, Christopher L; Toyoizumi, Taro

    2018-01-01

    During active behaviours like running, swimming, whisking or sniffing, motor actions shape sensory input and sensory percepts guide future motor commands. Ongoing cycles of sensory and motor processing constitute a closed-loop feedback system which is central to motor control and, it has been argued, for perceptual processes. This closed-loop feedback is mediated by brainwide neural circuits but how the presence of feedback signals impacts on the dynamics and function of neurons is not well understood. Here we present a simple theory suggesting that closed-loop feedback between the brain/body/environment can modulate neural gain and, consequently, change endogenous neural fluctuations and responses to sensory input. We support this theory with modeling and data analysis in two vertebrate systems. First, in a model of rodent whisking we show that negative feedback mediated by whisking vibrissa can suppress coherent neural fluctuations and neural responses to sensory input in the barrel cortex. We argue this suppression provides an appealing account of a brain state transition (a marked change in global brain activity) coincident with the onset of whisking in rodents. Moreover, this mechanism suggests a novel signal detection mechanism that selectively accentuates active, rather than passive, whisker touch signals. This mechanism is consistent with a predictive coding strategy that is sensitive to the consequences of motor actions rather than the difference between the predicted and actual sensory input. We further support the theory by re-analysing previously published two-photon data recorded in zebrafish larvae performing closed-loop optomotor behaviour in a virtual swim simulator. We show, as predicted by this theory, that the degree to which each cell contributes in linking sensory and motor signals well explains how much its neural fluctuations are suppressed by closed-loop optomotor behaviour. More generally we argue that our results demonstrate the dependence

  1. Closed-loop control of grasping with a myoelectric hand prosthesis: which are the relevant feedback variables for force control?

    Science.gov (United States)

    Ninu, Andrei; Dosen, Strahinja; Muceli, Silvia; Rattay, Frank; Dietl, Hans; Farina, Dario

    2014-09-01

    In closed-loop control of grasping by hand prostheses, the feedback information sent to the user is usually the actual controlled variable, i.e., the grasp force. Although this choice is intuitive and logical, the force production is only the last step in the process of grasping. Therefore, this study evaluated the performance in controlling grasp strength using a hand prosthesis operated through a complete grasping sequence while varying the feedback variables (e.g., closing velocity, grasping force), which were provided to the user visually or through vibrotactile stimulation. The experiments were conducted on 13 volunteers who controlled the Otto Bock Sensor Hand Speed prosthesis. Results showed that vibrotactile patterns were able to replace the visual feedback. Interestingly, the experiments demonstrated that direct force feedback was not essential for the control of grasping force. The subjects were indeed able to control the grip strength, predictively, by estimating the grasping force from the prosthesis velocity of closing. Therefore, grasping without explicit force feedback is not completely blind, contrary to what is usually assumed. In our study we analyzed grasping with a specific prosthetic device, but the outcomes are also applicable for other devices, with one or more degrees-of-freedom. The necessary condition is that the electromyography (EMG) signal directly and proportionally controls the velocity/grasp force of the hand, which is a common approach among EMG controlled prosthetic devices. The results provide important indications on the design of closed-loop EMG controlled prosthetic systems.

  2. Open loop thanks to direct torque control (DTC). Motor control without feedback loop; Open loop dank direkter Drehmomentregelung (DTC). Hochwertige Motorregelung ohne Rueckfuehrung

    Energy Technology Data Exchange (ETDEWEB)

    Link, Michael [ABB Automation Products GmbH, Ladenburg (Germany)

    2009-07-01

    Servo drives are used in various applications. The range of applications is huge and thus also requirements to the drive system. Mainly, a fast torque and speed control is required. This is the domaine of direct torque control (DTC). In many applications DTC can meet this challenge to control the motor with full torque at zero speed. The servo converter based on DTC technology provides a control concept for synchronous and asynchronous motors for both closed loop and open loop control. DTC controlled drives support the whole range from open loop up to high performance motion control applications. (orig.)

  3. Closed-Loop Hybrid Gaze Brain-Machine Interface Based Robotic Arm Control with Augmented Reality Feedback

    Directory of Open Access Journals (Sweden)

    Hong Zeng

    2017-10-01

    Full Text Available Brain-machine interface (BMI can be used to control the robotic arm to assist paralysis people for performing activities of daily living. However, it is still a complex task for the BMI users to control the process of objects grasping and lifting with the robotic arm. It is hard to achieve high efficiency and accuracy even after extensive trainings. One important reason is lacking of sufficient feedback information for the user to perform the closed-loop control. In this study, we proposed a method of augmented reality (AR guiding assistance to provide the enhanced visual feedback to the user for a closed-loop control with a hybrid Gaze-BMI, which combines the electroencephalography (EEG signals based BMI and the eye tracking for an intuitive and effective control of the robotic arm. Experiments for the objects manipulation tasks while avoiding the obstacle in the workspace are designed to evaluate the performance of our method for controlling the robotic arm. According to the experimental results obtained from eight subjects, the advantages of the proposed closed-loop system (with AR feedback over the open-loop system (with visual inspection only have been verified. The number of trigger commands used for controlling the robotic arm to grasp and lift the objects with AR feedback has reduced significantly and the height gaps of the gripper in the lifting process have decreased more than 50% compared to those trials with normal visual inspection only. The results reveal that the hybrid Gaze-BMI user can benefit from the information provided by the AR interface, improving the efficiency and reducing the cognitive load during the grasping and lifting processes.

  4. Dynamical behaviors of Rb-E2F pathway including negative feedback loops involving miR449.

    Science.gov (United States)

    Yan, Fang; Liu, Haihong; Hao, Junjun; Liu, Zengrong

    2012-01-01

    MiRNAs, which are a family of small non-coding RNAs, regulate a broad array of physiological and developmental processes. However, their regulatory roles have remained largely mysterious. E2F is a positive regulator of cell cycle progression and also a potent inducer of apoptosis. Positive feedback loops in the regulation of Rb-E2F pathway are predicted and shown experimentally. Recently, it has been discovered that E2F induce a cluster of miRNAs called miR449. In turn, E2F is inhibited by miR449 through regulating different transcripts, thus forming negative feedback loops in the interaction network. Here, based on the integration of experimental evidence and quantitative data, we studied Rb-E2F pathway coupling the positive feedback loops and negative feedback loops mediated by miR449. Therefore, a mathematical model is constructed based in part on the model proposed in Yao-Lee et al. (2008) and nonlinear dynamical behaviors including the stability and bifurcations of the model are discussed. A comparison is given to reveal the implication of the fundamental differences of Rb-E2F pathway between regulation and deregulation of miR449. Coherent with the experiments it predicts that miR449 plays a critical role in regulating the cell cycle progression and provides a twofold safety mechanism to avoid excessive E2F-induced proliferation by cell cycle arrest and apoptosis. Moreover, numerical simulation and bifurcation analysis shows that the mechanisms of the negative regulation of miR449 to three different transcripts are quite distinctive which needs to be verified experimentally. This study may help us to analyze the whole cell cycle process mediated by other miRNAs more easily. A better knowledge of the dynamical behaviors of miRNAs mediated networks is also of interest for bio-engineering and artificial control.

  5. Dynamical behaviors of Rb-E2F pathway including negative feedback loops involving miR449.

    Directory of Open Access Journals (Sweden)

    Fang Yan

    Full Text Available MiRNAs, which are a family of small non-coding RNAs, regulate a broad array of physiological and developmental processes. However, their regulatory roles have remained largely mysterious. E2F is a positive regulator of cell cycle progression and also a potent inducer of apoptosis. Positive feedback loops in the regulation of Rb-E2F pathway are predicted and shown experimentally. Recently, it has been discovered that E2F induce a cluster of miRNAs called miR449. In turn, E2F is inhibited by miR449 through regulating different transcripts, thus forming negative feedback loops in the interaction network. Here, based on the integration of experimental evidence and quantitative data, we studied Rb-E2F pathway coupling the positive feedback loops and negative feedback loops mediated by miR449. Therefore, a mathematical model is constructed based in part on the model proposed in Yao-Lee et al. (2008 and nonlinear dynamical behaviors including the stability and bifurcations of the model are discussed. A comparison is given to reveal the implication of the fundamental differences of Rb-E2F pathway between regulation and deregulation of miR449. Coherent with the experiments it predicts that miR449 plays a critical role in regulating the cell cycle progression and provides a twofold safety mechanism to avoid excessive E2F-induced proliferation by cell cycle arrest and apoptosis. Moreover, numerical simulation and bifurcation analysis shows that the mechanisms of the negative regulation of miR449 to three different transcripts are quite distinctive which needs to be verified experimentally. This study may help us to analyze the whole cell cycle process mediated by other miRNAs more easily. A better knowledge of the dynamical behaviors of miRNAs mediated networks is also of interest for bio-engineering and artificial control.

  6. A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition.

    Directory of Open Access Journals (Sweden)

    Michèle Moes

    Full Text Available BACKGROUND: The majority of human cancer deaths are caused by metastasis. The metastatic dissemination is initiated by the breakdown of epithelial cell homeostasis. During this phenomenon, referred to as epithelial to mesenchymal transition (EMT, cells change their genetic and trancriptomic program leading to phenotypic and functional alterations. The challenge of understanding this dynamic process resides in unraveling regulatory networks involving master transcription factors (e.g. SNAI1/2, ZEB1/2 and TWIST1 and microRNAs. Here we investigated microRNAs regulated by SNAI1 and their potential role in the regulatory networks underlying epithelial plasticity. RESULTS: By a large-scale analysis on epithelial plasticity, we highlighted miR-203 and its molecular link with SNAI1 and the miR-200 family, key regulators of epithelial homeostasis. During SNAI1-induced EMT in MCF7 breast cancer cells, miR-203 and miR-200 family members were repressed in a timely correlated manner. Importantly, miR-203 repressed endogenous SNAI1, forming a double negative miR203/SNAI1 feedback loop. We integrated this novel miR203/SNAI1 with the known miR200/ZEB feedback loops to construct an a priori EMT core network. Dynamic simulations revealed stable epithelial and mesenchymal states, and underscored the crucial role of the miR203/SNAI1 feedback loop in state transitions underlying epithelial plasticity. CONCLUSION: By combining computational biology and experimental approaches, we propose a novel EMT core network integrating two fundamental negative feedback loops, miR203/SNAI1 and miR200/ZEB. Altogether our analysis implies that this novel EMT core network could function as a switch controlling epithelial cell plasticity during differentiation and cancer progression.

  7. Closed-Loop Hybrid Gaze Brain-Machine Interface Based Robotic Arm Control with Augmented Reality Feedback

    Science.gov (United States)

    Zeng, Hong; Wang, Yanxin; Wu, Changcheng; Song, Aiguo; Liu, Jia; Ji, Peng; Xu, Baoguo; Zhu, Lifeng; Li, Huijun; Wen, Pengcheng

    2017-01-01

    Brain-machine interface (BMI) can be used to control the robotic arm to assist paralysis people for performing activities of daily living. However, it is still a complex task for the BMI users to control the process of objects grasping and lifting with the robotic arm. It is hard to achieve high efficiency and accuracy even after extensive trainings. One important reason is lacking of sufficient feedback information for the user to perform the closed-loop control. In this study, we proposed a method of augmented reality (AR) guiding assistance to provide the enhanced visual feedback to the user for a closed-loop control with a hybrid Gaze-BMI, which combines the electroencephalography (EEG) signals based BMI and the eye tracking for an intuitive and effective control of the robotic arm. Experiments for the objects manipulation tasks while avoiding the obstacle in the workspace are designed to evaluate the performance of our method for controlling the robotic arm. According to the experimental results obtained from eight subjects, the advantages of the proposed closed-loop system (with AR feedback) over the open-loop system (with visual inspection only) have been verified. The number of trigger commands used for controlling the robotic arm to grasp and lift the objects with AR feedback has reduced significantly and the height gaps of the gripper in the lifting process have decreased more than 50% compared to those trials with normal visual inspection only. The results reveal that the hybrid Gaze-BMI user can benefit from the information provided by the AR interface, improving the efficiency and reducing the cognitive load during the grasping and lifting processes. PMID:29163123

  8. A Feed-forward Geometrical Compensation and Adaptive Feedback Control Algorithm for Hydraulic Robot Manipulators

    DEFF Research Database (Denmark)

    Conrad, Finn; Zhou, Jianjun; Gabacik, Andrzej

    1998-01-01

    Invited paper presents a new control algorithm based on feed-forward geometrical compensation strategy combined with adaptive feedback control.......Invited paper presents a new control algorithm based on feed-forward geometrical compensation strategy combined with adaptive feedback control....

  9. Experimental test of an eco-evolutionary dynamic feedback loop between evolution and population density in the green peach aphid.

    Science.gov (United States)

    Turcotte, Martin M; Reznick, David N; Daniel Hare, J

    2013-05-01

    An eco-evolutionary feedback loop is defined as the reciprocal impacts of ecology on evolutionary dynamics and evolution on ecological dynamics on contemporary timescales. We experimentally tested for an eco-evolutionary feedback loop in the green peach aphid, Myzus persicae, by manipulating initial densities and evolution. We found strong evidence that initial aphid density alters the rate and direction of evolution, as measured by changes in genotype frequencies through time. We also found that evolution of aphids within only 16 days, or approximately three generations, alters the rate of population growth and predicts density compared to nonevolving controls. The impact of evolution on population dynamics also depended on density. In one evolution treatment, evolution accelerated population growth by up to 10.3% at high initial density or reduced it by up to 6.4% at low initial density. The impact of evolution on population growth was as strong as or stronger than that caused by a threefold change in intraspecific density. We found that, taken together, ecological condition, here intraspecific density, alters evolutionary dynamics, which in turn alter concurrent population growth rate (ecological dynamics) in an eco-evolutionary feedback loop. Our results suggest that ignoring evolution in studies predicting population dynamics might lead us to over- or underestimate population density and that we cannot predict the evolutionary outcome within aphid populations without considering population size.

  10. Hydraulic Design Criteria for Spacer Grids of Nuclear Fuel Element

    International Nuclear Information System (INIS)

    Juanico, Luis; Brasnarof, Daniel

    2000-01-01

    In this paper a hydraulic model for calculating the pressure drop on the CARA spacer grids is extended.This model is validated and feedback from experimental hydraulic test performed in a low pressure loop.The importance of the spacer grid geometric parameter (that is, its thickness and length, the number and kind of their fix spacer), developing hydraulic design criteria for spacer grid on fuel element

  11. HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance

    Directory of Open Access Journals (Sweden)

    Babak Nami

    2017-04-01

    Full Text Available HER2 receptor tyrosine kinase that is overexpressed in approximately 20% of all breast cancers (BCs is a poor prognosis factor and a precious target for BC therapy. Trastuzumab is approved by FDA to specifically target HER2 for treating HER2+ BC. However, about 60% of patients with HER2+ breast tumor develop de novo resistance to trastuzumab, partially due to the loss of expression of HER2 extracellular domain on their tumor cells. This is due to shedding/cleavage of HER2 by metalloproteinases (ADAMs and MMPs. HER2 shedding results in the accumulation of intracellular carboxyl-terminal HER2 (p95HER2, which is a common phenomenon in trastuzumab-resistant tumors and is suggested as a predictive marker for trastuzumab resistance. Up-regulation of the metalloproteinases is a poor prognosis factor and is commonly seen in mesenchymal-like cancer stem cells that are risen during epithelial to mesenchymal transition (EMT of tumor cells. HER2 cleavage during EMT can explain why secondary metastatic tumors with high percentage of mesenchymal-like cancer stem cells are mostly resistant to trastuzumab but still sensitive to lapatinib. Importantly, many studies report HER2 interaction with oncogenic/stemness signaling pathways including TGF-β/Smad, Wnt/β-catenin, Notch, JAK/STAT and Hedgehog. HER2 overexpression promotes EMT and the emergence of cancer stem cell properties in BC. Increased expression and activation of metalloproteinases during EMT leads to proteolytic cleavage and shedding of HER2 receptor, which downregulates HER2 extracellular domain and eventually increases trastuzumab resistance. Here, we review the hypothesis that a negative feedback loop between HER2 and stemness signaling drives resistance of BC to trastuzumab.

  12. Development of a thermal-hydraulic code for reflood analysis in a PWR experimental loop

    International Nuclear Information System (INIS)

    Alves, Sabrina P.; Mesquita, Amir Z.; Rezende, Hugo C.; Palma, Daniel A.P.

    2017-01-01

    A process of fundamental importance in the event of Loss of Coolant Accident (LOCA) in Pressurized Water nuclear Reactors (PWR) is the reflood of the core or rewetting of nuclear fuels. The Nuclear Technology Development Center (CDTN) has been developing since the 70’s programs to allow Brazil to become independent in the field of reactor safety analysis. To that end, in the 80’s was designed, assembled and commissioned one Rewetting Test Facility (ITR in Portuguese). This facility aims to investigate the phenomena involved in the thermal hydraulic reflood phase of a Loss of Coolant Accident in a PWR nuclear reactor. This work aim is the analysis of physical and mathematical models governing the rewetting phenomenon, and the development a thermo-hydraulic simulation code of a representative experimental circuit of the PWR reactors core cooling channels. It was possible to elaborate and develop a code called REWET. The results obtained with REWET were compared with the experimental results of the ITR, and with the results of the Hydroflut code, that was the old program previously used. An analysis was made of the evolution of the wall temperature of the test section as well as the evolution of the front for two typical tests using the two codes calculation, and experimental results. The result simulated by REWET code for the rewetting time also came closer to the experimental results more than those calculated by Hydroflut code. (author)

  13. Development of a thermal-hydraulic code for reflood analysis in a PWR experimental loop

    Energy Technology Data Exchange (ETDEWEB)

    Alves, Sabrina P.; Mesquita, Amir Z.; Rezende, Hugo C., E-mail: sabrinapral@gmail.com, E-mail: amir@cdtn.brm, E-mail: hcr@cdtn.br, E-mail: hcr@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Palma, Daniel A.P., E-mail: dapalma@cnen.gov.br [Comissão Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)

    2017-07-01

    A process of fundamental importance in the event of Loss of Coolant Accident (LOCA) in Pressurized Water nuclear Reactors (PWR) is the reflood of the core or rewetting of nuclear fuels. The Nuclear Technology Development Center (CDTN) has been developing since the 70’s programs to allow Brazil to become independent in the field of reactor safety analysis. To that end, in the 80’s was designed, assembled and commissioned one Rewetting Test Facility (ITR in Portuguese). This facility aims to investigate the phenomena involved in the thermal hydraulic reflood phase of a Loss of Coolant Accident in a PWR nuclear reactor. This work aim is the analysis of physical and mathematical models governing the rewetting phenomenon, and the development a thermo-hydraulic simulation code of a representative experimental circuit of the PWR reactors core cooling channels. It was possible to elaborate and develop a code called REWET. The results obtained with REWET were compared with the experimental results of the ITR, and with the results of the Hydroflut code, that was the old program previously used. An analysis was made of the evolution of the wall temperature of the test section as well as the evolution of the front for two typical tests using the two codes calculation, and experimental results. The result simulated by REWET code for the rewetting time also came closer to the experimental results more than those calculated by Hydroflut code. (author)

  14. OncomiR addiction is generated by a miR-155 feedback loop in Theileria-transformed leukocytes.

    Directory of Open Access Journals (Sweden)

    Justine Marsolier

    Full Text Available The intracellular parasite Theileria is the only eukaryote known to transform its mammalian host cells. We investigated the host mechanisms involved in parasite-induced transformation phenotypes. Tumour progression is a multistep process, yet 'oncogene addiction' implies that cancer cell growth and survival can be impaired by inactivating a single gene, offering a rationale for targeted molecular therapies. Furthermore, feedback loops often act as key regulatory hubs in tumorigenesis. We searched for microRNAs involved in addiction to regulatory loops in leukocytes infected with Theileria parasites. We show that Theileria transformation involves induction of the host bovine oncomiR miR-155, via the c-Jun transcription factor and AP-1 activity. We identified a novel miR-155 target, DET1, an evolutionarily-conserved factor involved in c-Jun ubiquitination. We show that miR-155 expression led to repression of DET1 protein, causing stabilization of c-Jun and driving the promoter activity of the BIC transcript containing miR-155. This positive feedback loop is critical to maintain the growth and survival of Theileria-infected leukocytes; transformation is reversed by inhibiting AP-1 activity or miR-155 expression. This is the first demonstration that Theileria parasites induce the expression of host non-coding RNAs and highlights the importance of a novel feedback loop in maintaining the proliferative phenotypes induced upon parasite infection. Hence, parasite infection drives epigenetic rewiring of the regulatory circuitry of host leukocytes, placing miR-155 at the crossroads between infection, regulatory circuits and transformation.

  15. Interleukin 6 promotes endometrial cancer growth through an autocrine feedback loop involving ERK–NF-κB signaling pathway

    Energy Technology Data Exchange (ETDEWEB)

    Che, Qi; Liu, Bin-Ya; Wang, Fang-Yuan; He, Yin-Yan; Lu, Wen; Liao, Yun [Department of Obstetrics and Gynecology, Shanghai First People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai (China); Gu, Wei, E-mail: krisgu70@163.com [Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai (China); Wan, Xiao-Ping, E-mail: wanxp@sjtu.edu.cn [Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital Affiliated to Tong Ji University, Shanghai (China)

    2014-03-28

    Highlights: • IL-6 could promote endometrial cancer cells proliferation. • IL-6 promotes its own production through an autocrine feedback loop. • ERK and NF-κB pathway inhibitors inhibit IL-6 production and tumor growth. • IL-6 secretion relies on the activation of ERK–NF-κB pathway axis. • An orthotopic nude endometrial carcinoma model confirms the effect of IL-6. - Abstract: Interleukin (IL)-6 as an inflammation factor, has been proved to promote cancer proliferation in several human cancers. However, its role in endometrial cancer has not been studied clearly. Previously, we demonstrated that IL-6 promoted endometrial cancer progression through local estrogen biosynthesis. In this study, we proved that IL-6 could directly stimulate endometrial cancer cells proliferation and an autocrine feedback loop increased its production even after the withdrawal of IL-6 from the medium. Next, we analyzed the mechanism underlying IL-6 production in the feedback loop and found that its production and IL-6-stimulated cell proliferation were effectively blocked by pharmacologic inhibitors of nuclear factor-kappa B (NF-κB) and extra-cellular signal-regulated kinase (ERK). Importantly, activation of ERK was upstream of the NF-κB pathways, revealing the hierarchy of this event. Finally, we used an orthotopic nude endometrial carcinoma model to confirm the effects of IL-6 on the tumor progression. Taken together, these data indicate that IL-6 promotes endometrial carcinoma growth through an expanded autocrine regulatory loop and implicate the ERK–NF-κB pathway as a critical mediator of IL-6 production, implying IL-6 to be an important therapeutic target in endometrial carcinoma.

  16. Flow resistance of orifices and spacers of BWR thermal-hydraulic and neutronic coupling loop

    International Nuclear Information System (INIS)

    Iguchi, Tadashi; Asaka, Hideaki; Nakamura, Hideo

    2002-03-01

    Authors are performing THYNC experiments to study thermal-hydraulic instability under neutronic and thermal-hydraulic coupling. In THYNC experiments, the orifices are installed at the exit of the test section and the spacers are installed in the test section, in order to properly simulate in-core thermal-hydraulics in the reactor core. It is necessary to know the flow resistance of the orifices and spacers for the analysis of THYNC experimental results. Consequently, authors measured the flow resistance of orifice and spacer under single-phase and two-phase flows. Using the experimental results, authors investigated the dependency of the flow resistances on the parameters, such as pressure, mass flux, an geometries. Furthermore, authors investigated the applicability of the basic two-phase flow models, for example the separate flow model, to the two-phase flow multiplier. As the result of the investigation on the single-phase flow experiment, it was found (1) that the effects of pressure and mass flux flow resistance are described by a function of Reynolds number, and (2) that flow resistances of the orifice and the spacer are calculated with the previous prediction methods. However, it was necessary to introduce an empirical coefficient, since it was difficult to predict accurately the flow resistance only with the previous prediction method due to the complicated geometry dependency, for example a flow area blockage ratio. On the other hand, according to the investigation on two-phase flow experiment, the followings were found. (1) Relation between the two-phase flow multiplier and the quality is regarded to be linear under pressure of 2MPa - 7MPa. The relation is dependent on pressure and geometry, and is little dependent on mass flux. (2) Relation between the two-phase flow multiplier and void fraction is little dependent on pressure, mass flux, and geometry under pressure of 0.2MPa - 7MPa and void fraction less than 0.6. The relation is less dependent on

  17. Air water loop - an experimental facility to study thermal hydraulics of AHWR steam drum

    International Nuclear Information System (INIS)

    Bagul, R.K.; Pilkhwal, D.S.; Jain, V.; Vijayan, P.K.

    2014-05-01

    In the proposed Indian Advanced Heavy Water Reactor (AHWR) the coolant recirculation in the primary system is achieved by two-phase natural circulation. The two-phase steam-water mixture from the reactor core is separated in steam drum by gravity. Gravity separation of phases may lead to undesirable phenomena - carryover and carryunder. Carryover is the entrainment of liquid droplets in the vapor phase.Carryover needs to be minimized to avoid erosion corrosion of turbine blades. Carryunder is the entrainment of vapor bubbles with liquid flowing back to reactor core. Significant carryunder may in turn lead to reduced flow resulting in reduced CHF margin and stability in the coolant channel. An Air-Water Loop (AWL) has been designed to carry out the experiments relevant to AHWR steam drum. The design features and scaling philosophy is described in this report. (author)

  18. Osteoclasts and CD8 T cells form a negative feedback loop that contributes to homeostasis of both the skeletal and immune systems.

    Science.gov (United States)

    Buchwald, Zachary S; Aurora, Rajeev

    2013-01-01

    There are a number of dynamic regulatory loops that maintain homeostasis of the immune and skeletal systems. In this review, we highlight a number of these regulatory interactions that contribute to maintaining homeostasis. In addition, we review data on a negative regulatory feedback loop between osteoclasts and CD8 T cells that contributes to homeostasis of both the skeletal and immune systems.

  19. The phenomenology of a small break LOCA in a complex thermal hydraulic loop

    International Nuclear Information System (INIS)

    Di Marzo, M.; Almenas, K.K.; Hsu, Y.Y.; Wang, Z.

    1988-01-01

    A phenomenological description of the thermal hydraulics events that take place during a simulated Small Break Loss of Coolant Accident (SB-LOCA) is presented. The SB-LOCA transient is described in detail and the various mass and energy transport modes are identified. Similar behavior is observed in other facilities designed for the simulation of this type of accidents. Previous investigations suggest a simple modelling of the phenomena based on fluid mechanic considerations. An extensive experimental program conducted at the experimental facility of the University of Maryland reveals that condensation is a dominant driving force for this type of transients. This finding has significant implications in the modelling of enthalpy transport for some of the flow modes which occur during the transient. In particular it affects the Interruption and Resumption Mode (IRM) during which enthalpy is transported by periodic flow of a two phase mixture. The efforts to predict the flow interruption based on fluid mechanic criteria of phase separation in the hot leg are shown to be misdirected since thermodynamic phenomena taking place in the horizontal portion of the cold legs and in the reactor vessel downcomer are mostly responsible for that transition. For flow resumption to occur the liquid-vapor mixture swelling in the vertical portion of the hot leg determines the occurrence of the liquid spill over the top of the candy cane. (orig.)

  20. Efficient phase locking of two dual-wavelength fiber amplifiers by an all-optical self-feedback loop

    Science.gov (United States)

    Lei, Bing; Chen, Keshan; Yao, Tianfu; Shi, Jianhua; Hu, Haojun

    2017-10-01

    Efficient phase locking of two dual-wavelength fiber amplifiers has been demonstrated by using a self-feedback coupling and intracavity filtering configuration, and the effect of bandwidth and wavelength spacing on their phase locking performances have been investigated in experiment. Two independent fiber lasers with different operating wavelength were combined incoherently by a 3 dB fiber coupler to form a dual-wavelength seed source laser, which was injected into the fiber amplifiers' coupling array through the self-feedback loop. The effect of bandwidth and wavelength spacing was researched by altering the seed laser's pump power and operating wavelengths respectively. As long as the feedback loop and the single-mode fiber filtering configuration were well constructed in the unidirectional ring laser cavity, stable phase locking states and high fringe visibility interference patterns could always be obtained in our experiment. When the spacing of two operating wavelength was varied from 1.6 nm to 19.6 nm, the fringe visibility decreased slightly with the increase of wavelength spacing, and the corresponding fringe visibility was always larger than 0.6. In conclusion, we believe that efficient phase locking of several multi-wavelength laser sources is also feasible by passive self-adjusting methods, and keeping the component laser beams' phase relationship stable and fixed is more important than controlling their operating wavelengths.

  1. Closing the Loop on Student Feedback: The Case of Australian and Scottish Universities

    Science.gov (United States)

    Shah, Mahsood; Cheng, Ming; Fitzgerald, Robert

    2017-01-01

    Universities have a long history of collecting student feedback using surveys and other mechanisms. The last decade has witnessed a significant shift in how student feedback is systematically collected, analysed, reported, and used by governments and institutions. This shift is due to a number of factors, including changes in government policy…

  2. Bidirectional neural interface: Closed-loop feedback control for hybrid neural systems.

    Science.gov (United States)

    Chou, Zane; Lim, Jeffrey; Brown, Sophie; Keller, Melissa; Bugbee, Joseph; Broccard, Frédéric D; Khraiche, Massoud L; Silva, Gabriel A; Cauwenberghs, Gert

    2015-01-01

    Closed-loop neural prostheses enable bidirectional communication between the biological and artificial components of a hybrid system. However, a major challenge in this field is the limited understanding of how these components, the two separate neural networks, interact with each other. In this paper, we propose an in vitro model of a closed-loop system that allows for easy experimental testing and modification of both biological and artificial network parameters. The interface closes the system loop in real time by stimulating each network based on recorded activity of the other network, within preset parameters. As a proof of concept we demonstrate that the bidirectional interface is able to establish and control network properties, such as synchrony, in a hybrid system of two neural networks more significantly more effectively than the same system without the interface or with unidirectional alternatives. This success holds promise for the application of closed-loop systems in neural prostheses, brain-machine interfaces, and drug testing.

  3. Trade typhoon over Japan: Turbulence metaphor and spatial production cycles feedback loops of the Japanese economy, 1980–85–90

    Directory of Open Access Journals (Sweden)

    M. Sonis

    2002-01-01

    Full Text Available This paper deals with the turbulence similitude between whirlpool structure of atmosphere disturbances and the spatial production cycles. Such an analogy leads to the production cycles feedback loops superposition analysis of trade feedbacks reflecting the economic phenomena of horizontal and vertical trade specifications. Moreover, the visualization of this process is achieved with the help of coloring the different permutation matrices presenting the hierarchy of production cycles feedback loops. In this manner the qualitative presentation of Japan inter-regional and inter-industry trade, 1980–85–90, is visualized and interpreted.

  4. Electro-optic chaotic system based on the reverse-time chaos theory and a nonlinear hybrid feedback loop.

    Science.gov (United States)

    Jiang, Xingxing; Cheng, Mengfan; Luo, Fengguang; Deng, Lei; Fu, Songnian; Ke, Changjian; Zhang, Minming; Tang, Ming; Shum, Ping; Liu, Deming

    2016-12-12

    A novel electro-optic chaos source is proposed on the basis of the reverse-time chaos theory and an analog-digital hybrid feedback loop. The analog output of the system can be determined by the numeric states of shift registers, which makes the system robust and easy to control. The dynamical properties as well as the complexity dependence on the feedback parameters are investigated in detail. The correlation characteristics of the system are also studied. Two improving strategies which were established in digital field and analog field are proposed to conceal the time-delay signature. The proposed scheme has the potential to be used in radar and optical secure communication systems.

  5. Application of non-linear discretetime feedback regulators with assignable closed-loop dynamics

    Directory of Open Access Journals (Sweden)

    Dubljević Stevan

    2003-01-01

    Full Text Available In the present work the application of a new approach is demonstrated to a discrete-time state feedback regulator synthesis with feedback linearization and pole-placement for non-linear discrete-time systems. Under the simultaneous implementation of a non-linear coordinate transformation and a non-linear state feedback law computed through the solution of a system of non-linear functional equations, both the feedback linearization and pole-placement design objectives were accomplished. The non-linear state feedback regulator synthesis method was applied to a continuous stirred tank reactor (CSTR under non-isothermal operating conditions that exhibits steady-state multiplicity. The control objective was to regulate the reactor at the middle unstable steady state by manipulating the rate of input heat in the reactor. Simulation studies were performed to evaluate the performance of the proposed non-linear state feedback regulator, as it was shown a non-linear state feedback regulator clearly outperformed a standard linear one, especially in the presence of adverse disturbance under which linear regulation at the unstable steady state was not feasible.

  6. Mitigation of pressure fluctuations in the discharge cone of hydraulic turbines using flow-feedback

    International Nuclear Information System (INIS)

    Tanasa, C; Susan-Resiga, R; Bosioc, A; Muntean, S

    2010-01-01

    Our previous experimental and numerical investigations of decelerated swirling flows in conical diffusers have demonstrated that water jet injection along the symmetry axis mitigates the pressure fluctuations associated with the precessing vortex rope. However, for swirling flows similar to Francis turbines operated at partial discharge, the jet becomes effective when the jet discharge is larger than 10% from the turbine discharge, leading to large volumetric losses when the jet is supplied from upstream the runner. As a result, we introduce in this paper a new approach for supplying the jet by using a fraction of the discharge collected downstream the conical diffuser. We present the technical implementation of this flow-feedback approach, and we investigated experimentally its capability in mitigating the pressure fluctuations generated by the precessing vortex rope. The main advantage of this flow-feedback approach is that is does not require additional energy to supply the jet and it does not decrease the turbine efficiency.

  7. In vivo argon laser vascular welding using thermal feedback: open and closed loop patency and collagen crosslinking

    Energy Technology Data Exchange (ETDEWEB)

    Small, W., LLNL

    1997-02-28

    An in vivo study of vascular welding with a fiber-delivered argon laser was conducted using a canine model. Longitudinal arteriotomies and venotomies were treated on femoral vein and artery. Laser energy was delivered to the vessel wall via a 400 {micro}m optical fiber. The surface temperature at the center of the laser spot was monitored in real time using a hollow glass optical fiber-based two-color infrared thermometer. The surface temperature was limited by either a room-temperature saline drip or direct feedback control of the laser using a mechanical shutter to alternately pass and block the laser. Acute patency was evaluated either visually (leak/no leak) or by in vivo burst pressure measurements. Biochemical assays were performed to investigate the possible laser-induced formation or destruction of enzymatically mediated covalent crosslinks between collagen molecules. Viable welds were created both with and without the use of feedback control. Tissues maintained at 50 C using feedback control had an elevated crosslink count compared to controls, while those irradiated without feedback control experienced a decrease. Differences between the volumetric heating associated with open and closed loop protocols may account for the different effects on collagen crosslinks. Covalent mechanisms may play a role in argon laser vascular fusion.

  8. Use of loop-seals for the control of the overpressures in hydraulic transients evolving in a sea service water system

    Energy Technology Data Exchange (ETDEWEB)

    Canetta, D.; Capozza, A.; Iovino, G.

    1985-01-01

    The transient response following pump trip-offs and start-ups was investigated in the sea water system of a nuclear power plant. Specific care was devoted to water column separation and cavity collapse phenomena. A computer program designed for analysis of complex hydraulic networks was used. It is found that dangerous overpressures can be avoided by the use of loop seals. The design of the vacuum breaker valves of the loop seals and the optimization of overall transient behavior is discussed. 1 reference.

  9. Professional Feedback Loop: How Can Practising Teachers’ Reflection Inform English Language Teacher Education?

    Directory of Open Access Journals (Sweden)

    Mona Evelyn Flognfeldt

    2016-04-01

    . The teacher reports were in connection with a year’s further-education course in English, which included a pedagogical development project at their own school. This study provides insights into what aspects of the subject the practising teachers defined as their main instructional challenges in the classroom and what their main learning outcomes were. The data for this article are critical reflections articulated by the teachers at the end of their projects. Based on qualitative content analysis, I identified salient language-pedagogical features and commonalities in the teachers’ conceptualisations of their role and priorities with respect to student learning. This kind of language teacher research can have important implications for the way English is taught in initial teacher education. Relevant teacher cognitions can be channelled back to student teachers to mediate their professional preparation in the teacher education programme and their future work as English teachers. The central language-pedagogical issues identified in their research can be used as analytical and reflective tools for student teachers in their preparation for the complex practicalities of the classroom. Exploring the research that practising teachers have conducted into challenges they identified can help students connect theory with practice as well as contribute to lowering the affective filter of novice teachers. This article ends with a discussion of possible forms that this professional feedback loop can take.Keywords: english language teacher education, professional development, teacher research and development, teacher learning, language pedagogy

  10. Investigation, development and application of optimal output feedback theory. Volume 2: Development of an optimal, limited state feedback outer-loop digital flight control system for 3-D terminal area operation

    Science.gov (United States)

    Broussard, J. R.; Halyo, N.

    1984-01-01

    This report contains the development of a digital outer-loop three dimensional radio navigation (3-D RNAV) flight control system for a small commercial jet transport. The outer-loop control system is designed using optimal stochastic limited state feedback techniques. Options investigated using the optimal limited state feedback approach include integrated versus hierarchical control loop designs, 20 samples per second versus 5 samples per second outer-loop operation and alternative Type 1 integration command errors. Command generator tracking techniques used in the digital control design enable the jet transport to automatically track arbitrary curved flight paths generated by waypoints. The performance of the design is demonstrated using detailed nonlinear aircraft simulations in the terminal area, frequency domain multi-input sigma plots, frequency domain single-input Bode plots and closed-loop poles. The response of the system to a severe wind shear during a landing approach is also presented.

  11. The light cycle controls the hatching rhythm in Bombyx mori via negative feedback loop of the circadian oscillator.

    Science.gov (United States)

    Tao, Hui; Li, Xue; Qiu, Jian-Feng; Liu, Heng-Jiang; Zhang, Da-Yan; Chu, Feng; Sima, Yanghu; Xu, Shi-Qing

    2017-10-01

    Hatching behavior is a key target in silkworm (Bombyx mori) rearing, especially for the control of Lepidoptera pests. According to previous research, hatching rhythms appear to be controlled by a clock mechanism that restricts or "gates" hatching to a particular time. However, the underlying mechanism remains elusive. Under 12-h light:12-h dark photoperiod (LD) conditions, the transcriptional levels of the chitinase5 (Cht5) and hatching enzyme-like (Hel) genes, as well as the enzymatic activities of their gene products, oscillated in time with ambient light cycles, as did the transcriptional levels of the cryptochrome 1, cryptochrome 2, period (per), and timeless genes, which are key components of the negative feedback loop of the circadian rhythm. These changes were related to the expression profile of the ecdysteroid receptor gene and the hatching behavior of B. mori eggs. However, under continuous light or dark conditions, the hatching behavior, the expression levels of Cht5 and Hel, as well as the enzymatic activities of their gene products, were not synchronized unlike under LD conditions. In addition, immunohistochemistry experiments showed that light promoted the translocation of PER from the cytoplasm to the nucleus. In conclusion, LD cycles regulate the hatching rhythm of B. mori via negative feedback loop of the circadian oscillator. © 2017 Wiley Periodicals, Inc.

  12. The Y-located gonadoblastoma gene TSPY amplifies its own expression through a positive feedback loop in prostate cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Kido, Tatsuo; Lau, Yun-Fai Chris, E-mail: Chris.Lau@UCSF.edu

    2014-03-28

    Highlights: • Y-encoded proto-oncoprotein TSPY amplifies its expression level via a positive feedback loop. • TSPY binds to the chromatin/DNA at exon 1 of TSPY gene. • TSPY enhances the gene expression in a TSPY exon 1 sequence dependent manner. • The conserved SET/NAP-domain is essential for TSPY transactivation. • Insights on probable mechanisms on TSPY exacerbation on cancer development in men. - Abstract: The testis-specific protein Y-encoded (TSPY) is a repetitive gene located on the gonadoblastoma region of the Y chromosome, and has been considered to be the putative gene for this oncogenic locus on the male-only chromosome. It is expressed in spermatogonial cells and spermatocytes in normal human testis, but abundantly in gonadoblastoma, testicular germ cell tumors and a variety of somatic cancers, including melanoma, hepatocellular carcinoma and prostate cancer. Various studies suggest that TSPY accelerates cell proliferation and growth, and promotes tumorigenesis. In this report, we show that TSPY could bind directly to the chromatin/DNA at exon 1 of its own gene, and greatly enhance the transcriptional activities of the endogenous gene in the LNCaP prostate cancer cells. Domain mapping analyses of TSPY have localized the critical and sufficient domain to the SET/NAP-domain. These results suggest that TSPY could efficiently amplify its expression and oncogenic functions through a positive feedback loop, and contribute to the overall tumorigenic processes when it is expressed in various human cancers.

  13. Instrumentation and Control Systems for Sodium thermal hydraulic Experiment Loop for Finned-tube sodium-to-Air heat exchanger (SELFA)

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byeong Yeon; Kim, Hyung Mo; Cho, Youn Gil; Kim, Jong Man; Ko, Yung Joo; Kang, Byeong Su; Jung, Min Hwan; Jeong, Ji Young [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    A forced-draft sodium-to-air heat exchanger (FHX) is a part of decay heat removal system (DHRS) in Prototype Gen-IV Sodium-cooled fast reactor (PGSFR), which is being developed at Korea Atomic Energy Research Institute (KAERI). Sodium thermal hydraulic Experiment Loop for Finned-tube sodium-to-Air heat exchanger (SELFA) is a test facility for verification and validation of the design code for a forced-draft sodium-to-air heat exchanger (FHX). In this paper, we have provided design and fabrication features for the instrumentation and control systems of SELFA. In general, the instrumentation systems and control systems are coupled for measurement and control of process variables. Instrumentation systems have been designed for investigating thermal-hydraulic characteristics of FHX and control systems have been designed to control the main components (e.g. electromagnetic pumps, heaters, valves etc.) required for test in SELFA. In this paper, we have provided configurations of instrumentation and control systems for Sodium thermal hydraulic Experiment Loop for Finned-tube sodium-to-Air heat exchanger (SELFA). The instrumentation and control systems of SELFA have been implemented based on the expected operation ranges and lesson learned from operational experience of 'Sodium integral effect test loop for safety simulation and assessment-1' (STELLA-1)

  14. Pdlim7 is required for maintenance of the mesenchymal/epidermal Fgf signaling feedback loop during zebrafish pectoral fin development

    Directory of Open Access Journals (Sweden)

    Klosowiak Julian

    2010-10-01

    Full Text Available Abstract Background Vertebrate limb development involves a reciprocal feedback loop between limb mesenchyme and the overlying apical ectodermal ridge (AER. Several gene pathways participate in this feedback loop, including Fgf signaling. In the forelimb lateral plate mesenchyme, Tbx5 activates Fgf10 expression, which in turn initiates and maintains the mesenchyme/AER Fgf signaling loop. Recent findings have revealed that Tbx5 transcriptional activity is regulated by dynamic nucleocytoplasmic shuttling and interaction with Pdlim7, a PDZ-LIM protein family member, along actin filaments. This Tbx5 regulation is critical in heart formation, but the coexpression of both proteins in other developing tissues suggests a broader functional role. Results Knock-down of Pdlim7 function leads to decreased pectoral fin cell proliferation resulting in a severely stunted fin phenotype. While early gene induction and patterning in the presumptive fin field appear normal, the pectoral fin precursor cells display compaction and migration defects between 18 and 24 hours post-fertilization (hpf. During fin growth fgf24 is sequentially expressed in the mesenchyme and then in the apical ectodermal ridge (AER. However, in pdlim7 antisense morpholino-treated embryos this switch of expression is prevented and fgf24 remains ectopically active in the mesenchymal cells. Along with the lack of fgf24 in the AER, other critical factors including fgf8 are reduced, suggesting signaling problems to the underlying mesenchyme. As a consequence of perturbed AER function in the absence of Pdlim7, pathway components in the fin mesenchyme are misregulated or absent, indicating a breakdown of the Fgf signaling feedback loop, which is ultimately responsible for the loss of fin outgrowth. Conclusion This work provides the first evidence for the involvement of Pdlim7 in pectoral fin development. Proper fin outgrowth requires fgf24 downregulation in the fin mesenchyme with subsequent

  15. State Feedback Decoupling with In-Loop Lead Compensator in Stand-Alone VSIs

    DEFF Research Database (Denmark)

    Federico, de Bosio; Pastorelli, Michele; de Sousa Ribeiro, Luiz Antonio

    2016-01-01

    The performance of current and voltage regulators during transients and steady-state is of primary concern for power converters intended for stand-alone applications. Dynamics performance and command tracking capability are enhanced by actively decoupling the controlled states variables. To further...... widen the current loop bandwidth while still preserving a well-damped system a lead compensator structure on the forward loop is proposed. A 3 kHz bandwidth with 0.707 damping factor is achieved for the inner current controller. Accordingly, also the voltage regulator bandwidth can be widen, thus...

  16. Why do quality and reliability feedback loops not always work in practice: a case study

    Energy Technology Data Exchange (ETDEWEB)

    Molenaar, P.A.; Huijben, A.J.M.; Bouwhuis, D.; Brombacher, A.C

    2002-03-01

    The increasing competition in the market of consumer electronics forces industry to simultaneously improve the functionability, reliability and costs of their products. Due to the strong dynamics of this field an important measure in improving product quality is the feedback of information on actual field behaviour of a product which is extremely relevant for product development. This information, usually gathered by the service department, can help development to learn from the failures of earlier products and to improve the next product generations. This feedback process, however, does not always bring the expected benefits. This paper presents a model, based on an actual case study, of the structure of the feedback process in terms of information flows. The information flow model describes the chain or network of activities in the feedback process as a function of (different) drivers such as cost, time or quality. Using this information flow model it is possible to explain how quality and reliability related information propagates through a business process and where and why communication problems lead to disruptions in the feedback of this information. With this model, it is easier to understand the function of different parties in the service or after sales process, so that management of the information in this process becomes more transparent and can be improved.

  17. Why do quality and reliability feedback loops not always work in practice: a case study

    International Nuclear Information System (INIS)

    Molenaar, P.A.; Huijben, A.J.M.; Bouwhuis, D.; Brombacher, A.C.

    2002-01-01

    The increasing competition in the market of consumer electronics forces industry to simultaneously improve the functionability, reliability and costs of their products. Due to the strong dynamics of this field an important measure in improving product quality is the feedback of information on actual field behaviour of a product which is extremely relevant for product development. This information, usually gathered by the service department, can help development to learn from the failures of earlier products and to improve the next product generations. This feedback process, however, does not always bring the expected benefits. This paper presents a model, based on an actual case study, of the structure of the feedback process in terms of information flows. The information flow model describes the chain or network of activities in the feedback process as a function of (different) drivers such as cost, time or quality. Using this information flow model it is possible to explain how quality and reliability related information propagates through a business process and where and why communication problems lead to disruptions in the feedback of this information. With this model, it is easier to understand the function of different parties in the service or after sales process, so that management of the information in this process becomes more transparent and can be improved

  18. Numerical static state feedback laws for closed-loop singular optimal control

    NARCIS (Netherlands)

    Graaf, de S.C.; Stigter, J.D.; Straten, van G.

    2005-01-01

    Singular and non-singular control trajectories of agricultural and (bio) chemical processes may need to be recalculated from time to time for use in closed-loop optimal control, because of unforeseen changes in state values and noise. This is time consuming. As an alternative, in this paper,

  19. Construction and modelling of an inducible positive feedback loop stably integrated in a mammalian cell-line.

    Directory of Open Access Journals (Sweden)

    Velia Siciliano

    2011-06-01

    Full Text Available Understanding the relationship between topology and dynamics of transcriptional regulatory networks in mammalian cells is essential to elucidate the biology of complex regulatory and signaling pathways. Here, we characterised, via a synthetic biology approach, a transcriptional positive feedback loop (PFL by generating a clonal population of mammalian cells (CHO carrying a stable integration of the construct. The PFL network consists of the Tetracycline-controlled transactivator (tTA, whose expression is regulated by a tTA responsive promoter (CMV-TET, thus giving rise to a positive feedback. The same CMV-TET promoter drives also the expression of a destabilised yellow fluorescent protein (d2EYFP, thus the dynamic behaviour can be followed by time-lapse microscopy. The PFL network was compared to an engineered version of the network lacking the positive feedback loop (NOPFL, by expressing the tTA mRNA from a constitutive promoter. Doxycycline was used to repress tTA activation (switch off, and the resulting changes in fluorescence intensity for both the PFL and NOPFL networks were followed for up to 43 h. We observed a striking difference in the dynamics of the PFL and NOPFL networks. Using non-linear dynamical models, able to recapitulate experimental observations, we demonstrated a link between network topology and network dynamics. Namely, transcriptional positive autoregulation can significantly slow down the "switch off" times, as compared to the non-autoregulated system. Doxycycline concentration can modulate the response times of the PFL, whereas the NOPFL always switches off with the same dynamics. Moreover, the PFL can exhibit bistability for a range of Doxycycline concentrations. Since the PFL motif is often found in naturally occurring transcriptional and signaling pathways, we believe our work can be instrumental to characterise their behaviour.

  20. Construction and modelling of an inducible positive feedback loop stably integrated in a mammalian cell-line.

    Science.gov (United States)

    Siciliano, Velia; Menolascina, Filippo; Marucci, Lucia; Fracassi, Chiara; Garzilli, Immacolata; Moretti, Maria Nicoletta; di Bernardo, Diego

    2011-06-01

    Understanding the relationship between topology and dynamics of transcriptional regulatory networks in mammalian cells is essential to elucidate the biology of complex regulatory and signaling pathways. Here, we characterised, via a synthetic biology approach, a transcriptional positive feedback loop (PFL) by generating a clonal population of mammalian cells (CHO) carrying a stable integration of the construct. The PFL network consists of the Tetracycline-controlled transactivator (tTA), whose expression is regulated by a tTA responsive promoter (CMV-TET), thus giving rise to a positive feedback. The same CMV-TET promoter drives also the expression of a destabilised yellow fluorescent protein (d2EYFP), thus the dynamic behaviour can be followed by time-lapse microscopy. The PFL network was compared to an engineered version of the network lacking the positive feedback loop (NOPFL), by expressing the tTA mRNA from a constitutive promoter. Doxycycline was used to repress tTA activation (switch off), and the resulting changes in fluorescence intensity for both the PFL and NOPFL networks were followed for up to 43 h. We observed a striking difference in the dynamics of the PFL and NOPFL networks. Using non-linear dynamical models, able to recapitulate experimental observations, we demonstrated a link between network topology and network dynamics. Namely, transcriptional positive autoregulation can significantly slow down the "switch off" times, as compared to the non-autoregulated system. Doxycycline concentration can modulate the response times of the PFL, whereas the NOPFL always switches off with the same dynamics. Moreover, the PFL can exhibit bistability for a range of Doxycycline concentrations. Since the PFL motif is often found in naturally occurring transcriptional and signaling pathways, we believe our work can be instrumental to characterise their behaviour.

  1. Closed-loop feedback of MHD instabilities on DIII-D

    Energy Technology Data Exchange (ETDEWEB)

    Fredrickson, E.D.; Johnson, L.C.; Manickam, J.; Okabayashi, M. [Princeton Plasma Physics Laboratory, Princeton, NJ 08543 (United States); Bialek, J.; Garofalo, A.M.; Navratil, G.A. [Columbia University, New York, NY 10027 (United States); La Haye, R.J.; Scoville, J.T.; Strait, E.J. [General Atomics, La Jolla, CA 92186 (United States); Lazarus, E.A. [Oak Ridge National Laboratory, Oak Ridge, TN 37830 (United States)

    2001-03-01

    A system of coils, sensors and amplifiers has been installed on the DIII-D tokamak to study the physics of feedback stabilization of low-frequency MHD modes such as the resistive wall mode (RWM). Experiments are being performed to assess the effectiveness of this minimal system and benchmark the predictions of theoretical models and codes. In the last campaign the experiments had been extended to a regime where the RWM threshold is lowered by a fast ramp of the plasma current. In these experiments the onset time of the RWM is very reproducible. With this system, the onset of the RWM had been delayed by up to 100 ms without degrading the plasma performance. The growth rate of the mode increases proportional to the length of the delay, suggesting that the plasma is evolving towards a more unstable configuration. The present results have suggested directions for improving the feedback system, including better sensors and improved feedback algorithms. (author)

  2. Temperature control feedback loops for the linac upgrade side coupled cavities at Fermilab

    International Nuclear Information System (INIS)

    Crisp, J.

    1990-01-01

    The linac upgrade project at Fermilab will replace the last 4 drift-tube linac tanks with seven side coupled cavity strings. This will increase the beam energy from 200 to 400 MeV at injection into the Booster accelerator. The main objective of the temperature loop is to control the resonant frequency of the cavity strings. A cavity string will constant of 4 sections connected with bridge couplers driven with a 12 MW klystron at 805 MHz. Each section is a side coupled cavity chain consisting of 16 accelerating cells and 15 side coupling cells. For the linac upgrade, 7 full cavity strings will be used. A separate temperature control system is planned for each of the 28 accelerating sections, the two transition sections, and the debuncher section. The cavity strings will be tuned to resonance for full power beam loaded conditions. A separate frequency loop is planned that will sample the phase difference between a monitor placed in the end cell of each section and the rf drive. The frequency loop will control the set point for the temperature loop which will be able to maintain the resonant frequency through periods within beam or rf power. The frequency loop will need the intelligence required to determine under what conditions the phase error information is valid and the temperature set point should be adjusted. This paper will discuss some of the reason for temperature control, the implementation, and some of the problems encountered. An appendix contains some useful constants and descriptions of some of the sensor and control elements used. 13 figs

  3. Numerical experiment on variance biases and Monte Carlo neutronics analysis with thermal hydraulic feedback

    International Nuclear Information System (INIS)

    Hyung, Jin Shim; Beom, Seok Han; Chang, Hyo Kim

    2003-01-01

    Monte Carlo (MC) power method based on the fixed number of fission sites at the beginning of each cycle is known to cause biases in the variances of the k-eigenvalue (keff) and the fission reaction rate estimates. Because of the biases, the apparent variances of keff and the fission reaction rate estimates from a single MC run tend to be smaller or larger than the real variances of the corresponding quantities, depending on the degree of the inter-generational correlation of the sample. We demonstrate this through a numerical experiment involving 100 independent MC runs for the neutronics analysis of a 17 x 17 fuel assembly of a pressurized water reactor (PWR). We also demonstrate through the numerical experiment that Gelbard and Prael's batch method and Ueki et al's covariance estimation method enable one to estimate the approximate real variances of keff and the fission reaction rate estimates from a single MC run. We then show that the use of the approximate real variances from the two-bias predicting methods instead of the apparent variances provides an efficient MC power iteration scheme that is required in the MC neutronics analysis of a real system to determine the pin power distribution consistent with the thermal hydraulic (TH) conditions of individual pins of the system. (authors)

  4. Net Metering and Market Feedback Loops: Exploring the Impact of Retail Rate Design on Distributed PV Deployment

    Energy Technology Data Exchange (ETDEWEB)

    Darghouth, Naïm R. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Wiser, Ryan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Barbose, Galen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Mills, Andrew [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-01-13

    The substantial increase in deployment of customer-sited solar photovoltaics (PV) in the United States has been driven by a combination of steeply declining costs, financing innovations, and supportive policies. Among those supportive policies is net metering, which in most states effectively allows customers to receive compensation for distributed PV generation at the full retail electricity price. The current design of retail electricity rates and the presence of net metering have elicited concerns that the possible under-recovery of fixed utility costs from PV system owners may lead to a feedback loop of increasing retail prices that accelerate PV adoption and further rate increases. However, a separate and opposing feedback loop could offset this effect: increased PV deployment may lead to a shift in the timing of peak-period electricity prices that could reduce the bill savings received under net metering where time-varying retail electricity rates are used, thereby dampening further PV adoption. In this paper, we examine the impacts of these two competing feedback dynamics on U.S. distributed PV deployment through 2050 for both residential and commercial customers, across states. Our results indicate that, at the aggregate national level, the two feedback effects nearly offset one another and therefore produce a modest net effect, although their magnitude and direction vary by customer segment and by state. We also model aggregate PV deployment trends under various rate designs and net-metering rules, accounting for feedback dynamics. Our results demonstrate that future adoption of distributed PV is highly sensitive to retail rate structures. Whereas flat, time-invariant rates with net metering lead to higher aggregate national deployment levels than the current mix of rate structures (+5% in 2050), rate structures with higher monthly fixed customer charges or PV compensation at levels lower than the full retail rate can dramatically erode aggregate customer

  5. The effect of sensory feedback on crayfish posture and locomotion: II. Neuromechanical simulation of closing the loop.

    Science.gov (United States)

    Bacqué-Cazenave, Julien; Chung, Bryce; Cofer, David W; Cattaert, Daniel; Edwards, Donald H

    2015-03-15

    Neuromechanical simulation was used to determine whether proposed thoracic circuit mechanisms for the control of leg elevation and depression in crayfish could account for the responses of an experimental hybrid neuromechanical preparation when the proprioceptive feedback loop was open and closed. The hybrid neuromechanical preparation consisted of a computational model of the fifth crayfish leg driven in real time by the experimentally recorded activity of the levator and depressor (Lev/Dep) nerves of an in vitro preparation of the crayfish thoracic nerve cord. Up and down movements of the model leg evoked by motor nerve activity released and stretched the model coxobasal chordotonal organ (CBCO); variations in the CBCO length were used to drive identical variations in the length of the live CBCO in the in vitro preparation. CBCO afferent responses provided proprioceptive feedback to affect the thoracic motor output. Experiments performed with this hybrid neuromechanical preparation were simulated with a neuromechanical model in which a computational circuit model represented the relevant thoracic circuitry. Model simulations were able to reproduce the hybrid neuromechanical experimental results to show that proposed circuit mechanisms with sensory feedback could account for resistance reflexes displayed in the quiescent state and for reflex reversal and spontaneous Lev/Dep bursting seen in the active state. Copyright © 2015 the American Physiological Society.

  6. Why do quality and reliability feedback loops not always work in practice: a case study

    NARCIS (Netherlands)

    Molenaar, P.A.; Huijben, A.J.M.; Bouwhuis, D.G.; Brombacher, A.C.

    2002-01-01

    The increasing competition in the market of consumer electronics forces industry to simultaneously improve the functionability, reliability and costs of their products. Due to the strong dynamics of this field an important measure in improving product quality is the feedback of information on actual

  7. Chaotic Feedback Loops within Decision Making Groups: Towards an Integration of Chaos Theory and Cybernetics.

    Science.gov (United States)

    Keaten, James A.

    This paper offers a model that integrates chaos theory and cybernetics, which can be used to describe the structure of decision making within small groups. The paper begins with an overview of cybernetics and chaos. Definitional characteristics of cybernetics are reviewed along with salient constructs, such as goal-seeking, feedback, feedback…

  8. Feedback from uncertainties propagation research projects conducted in different hydraulic fields: outcomes for engineering projects and nuclear safety assessment.

    Science.gov (United States)

    Bacchi, Vito; Duluc, Claire-Marie; Bertrand, Nathalie; Bardet, Lise

    2017-04-01

    In recent years, in the context of hydraulic risk assessment, much effort has been put into the development of sophisticated numerical model systems able reproducing surface flow field. These numerical models are based on a deterministic approach and the results are presented in terms of measurable quantities (water depths, flow velocities, etc…). However, the modelling of surface flows involves numerous uncertainties associated both to the numerical structure of the model, to the knowledge of the physical parameters which force the system and to the randomness inherent to natural phenomena. As a consequence, dealing with uncertainties can be a difficult task for both modelers and decision-makers [Ioss, 2011]. In the context of nuclear safety, IRSN assesses studies conducted by operators for different reference flood situations (local rain, small or large watershed flooding, sea levels, etc…), that are defined in the guide ASN N°13 [ASN, 2013]. The guide provides some recommendations to deal with uncertainties, by proposing a specific conservative approach to cover hydraulic modelling uncertainties. Depending of the situation, the influencing parameter might be the Strickler coefficient, levee behavior, simplified topographic assumptions, etc. Obviously, identifying the most influencing parameter and giving it a penalizing value is challenging and usually questionable. In this context, IRSN conducted cooperative (Compagnie Nationale du Rhone, I-CiTy laboratory of Polytech'Nice, Atomic Energy Commission, Bureau de Recherches Géologiques et Minières) research activities since 2011 in order to investigate feasibility and benefits of Uncertainties Analysis (UA) and Global Sensitivity Analysis (GSA) when applied to hydraulic modelling. A specific methodology was tested by using the computational environment Promethee, developed by IRSN, which allows carrying out uncertainties propagation study. This methodology was applied with various numerical models and in

  9. Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing

    OpenAIRE

    Trumper, David; Kassis, Timothy; Griffith, Linda; Noh, Minkyun; Soenksen, Luis

    2018-01-01

    Precise fluid height sensing in open-channel microfluidics has long been a desirable feature for a wide range of applications. However, performing accurate measurements of the fluid level in small-scale reservoirs (<1mL) has proven to be an elusive goal, especially if direct fluid-sensor contact needs to be avoided. In particular, gravity-driven systems used in several microfluidic applications to establish pressure gradients and impose flow remain open-loop and largely unmonitored due to ...

  10. Voltage regulator for on-board CMS ECAL powering : dynamic stability of the feedback loop

    CERN Document Server

    Wertelaers, P

    2010-01-01

    Traditionally, a capacitor is parallelled to the load of the regulator. Its main function is to steer (limit) the loop bandwidth. An ideal capacitor would provoke near-to-no dynamic stability. A typical remedy, not always elegant, is to select a device with appreciable parasitic series resistance. In this Note, and alternative method is proposed. The CMS ECAL regulator is of adjustable type, and adding a small capacitor at the divider there, brings about a "lead" type control action.

  11. Model-based rational feedback controller design for closed-loop deep brain stimulation of Parkinson's disease

    Science.gov (United States)

    Gorzelic, P.; Schiff, S. J.; Sinha, A.

    2013-04-01

    Objective. To explore the use of classical feedback control methods to achieve an improved deep brain stimulation (DBS) algorithm for application to Parkinson's disease (PD). Approach. A computational model of PD dynamics was employed to develop model-based rational feedback controller design. The restoration of thalamocortical relay capabilities to patients suffering from PD is formulated as a feedback control problem with the DBS waveform serving as the control input. Two high-level control strategies are tested: one that is driven by an online estimate of thalamic reliability, and another that acts to eliminate substantial decreases in the inhibition from the globus pallidus interna (GPi) to the thalamus. Control laws inspired by traditional proportional-integral-derivative (PID) methodology are prescribed for each strategy and simulated on this computational model of the basal ganglia network. Main Results. For control based upon thalamic reliability, a strategy of frequency proportional control with proportional bias delivered the optimal control achieved for a given energy expenditure. In comparison, control based upon synaptic inhibitory output from the GPi performed very well in comparison with those of reliability-based control, with considerable further reduction in energy expenditure relative to that of open-loop DBS. The best controller performance was amplitude proportional with derivative control and integral bias, which is full PID control. We demonstrated how optimizing the three components of PID control is feasible in this setting, although the complexity of these optimization functions argues for adaptive methods in implementation. Significance. Our findings point to the potential value of model-based rational design of feedback controllers for Parkinson's disease.

  12. Shaping meiotic chromosomes with SUMO: a feedback loop controls the assembly of the synaptonemal complex in budding yeast

    Directory of Open Access Journals (Sweden)

    Hideo Tsubouchi

    2016-02-01

    Full Text Available The synaptonemal complex (SC is a meiosis-specific chromosomal structure in which homologous chromosomes are intimately linked through arrays of specialized proteins called transverse filaments (TF. Widely conserved in eukaryote meiosis, the SC forms during prophase I and is essential for accurate segregation of homologous chromosomes at meiosis I. However, the basic mechanism overlooking formation and regulation of the SC has been poorly understood. By using the budding yeast Saccharomyces cerevisiae, we recently showed that SC formation is controlled through the attachment of multiple molecules of small ubiquitin-like modifier (SUMO to a regulator of TF assembly. Intriguingly, this SUMOylation is activated by TF, implicating the involvement of a positive feedback loop in the control of SC assembly. We discuss the implication of this finding and possible involvement of a similar mechanism in regulating other processes.

  13. Passive mode locking and formation of dissipative solitons in electron oscillators with a bleaching absorber in the feedback loop

    Energy Technology Data Exchange (ETDEWEB)

    Ginzburg, N. S., E-mail: ginzburg@appl.sci-nnov.ru; Kocharovskaya, E. R.; Vilkov, M. N.; Sergeev, A. S. [Russian Academy of Sciences, Institute of Applied Physics (Russian Federation)

    2017-01-15

    The mechanisms of passive mode locking and formation of ultrashort pulses in microwave electron oscillators with a bleaching absorber in the feedback loop have been analyzed. It is shown that in the group synchronism regime in which the translational velocity of particles coincides with the group velocity of the electromagnetic wave, the pulse formation can be described by the equations known in the theory of dissipative solitons. At the same time, the regimes in which the translational velocity of electrons differs from the group velocity and the soliton being formed and moving along the electron beam consecutively (cumulatively) receives energy from various electron fractions are optimal for generating pulses with the maximal peak amplitudes.

  14. New numerical methods for open-loop and feedback solutions to dynamic optimization problems

    Science.gov (United States)

    Ghosh, Pradipto

    The topic of the first part of this research is trajectory optimization of dynamical systems via computational swarm intelligence. Particle swarm optimization is a nature-inspired heuristic search method that relies on a group of potential solutions to explore the fitness landscape. Conceptually, each particle in the swarm uses its own memory as well as the knowledge accumulated by the entire swarm to iteratively converge on an optimal or near-optimal solution. It is relatively straightforward to implement and unlike gradient-based solvers, does not require an initial guess or continuity in the problem definition. Although particle swarm optimization has been successfully employed in solving static optimization problems, its application in dynamic optimization, as posed in optimal control theory, is still relatively new. In the first half of this thesis particle swarm optimization is used to generate near-optimal solutions to several nontrivial trajectory optimization problems including thrust programming for minimum fuel, multi-burn spacecraft orbit transfer, and computing minimum-time rest-to-rest trajectories for a robotic manipulator. A distinct feature of the particle swarm optimization implementation in this work is the runtime selection of the optimal solution structure. Optimal trajectories are generated by solving instances of constrained nonlinear mixed-integer programming problems with the swarming technique. For each solved optimal programming problem, the particle swarm optimization result is compared with a nearly exact solution found via a direct method using nonlinear programming. Numerical experiments indicate that swarm search can locate solutions to very great accuracy. The second half of this research develops a new extremal-field approach for synthesizing nearly optimal feedback controllers for optimal control and two-player pursuit-evasion games described by general nonlinear differential equations. A notable revelation from this development

  15. MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila

    Directory of Open Access Journals (Sweden)

    Kaveh Daneshvar

    2012-10-01

    The abundance of Myc protein must be exquisitely controlled to avoid growth abnormalities caused by too much or too little Myc. An intriguing mode of regulation exists in which Myc protein itself leads to reduction in its abundance. We show here that dMyc binds to the miR-308 locus and increases its expression. Using our gain-of-function approach, we show that an increase in miR-308 causes a destabilization of dMyc mRNA and reduced dMyc protein levels. In vivo knockdown of miR-308 confirmed the regulation of dMyc levels in embryos. This regulatory loop is crucial for maintaining appropriate dMyc levels and normal development. Perturbation of the loop, either by elevated miR-308 or elevated dMyc, caused lethality. Combining elevated levels of both, therefore restoring balance between miR-308 and dMyc levels, resulted in lower apoptotic activity and suppression of lethality. These results reveal a sensitive feedback mechanism that is crucial to prevent the pathologies caused by abnormal levels of dMyc.

  16. Nonlinear Power-Level Control of the MHTGR Only with the Feedback Loop of Helium Temperature

    Directory of Open Access Journals (Sweden)

    Zhe Dong

    2013-02-01

    Full Text Available Power-level control is a crucial technique for the safe, stable and efficient operation of modular high temperature gas-cooled nuclear reactors (MHTGRs, which have strong inherent safety features and high outlet temperatures. The current power-level controllers of the MHTGRs need measurements of both the nuclear power and the helium temperature, which cannot provide satisfactory control performance and can even induce large oscillations when the neutron sensors are in error. In order to improve the fault tolerance of the control system, it is important to develop a power-level control strategy that only requires the helium temperature. The basis for developing this kind of control law is to give a state-observer of the MHTGR a relationship that only needs the measurement of helium temperature. With this in mind, a novel nonlinear state observer which only needs the measurement of helium temperature is proposed. This observer is globally convergent if there is no disturbance, and has the L2 disturbance attenuation performance if the disturbance is nonzero. The separation principle of this observer is also proven, which denotes that this observer can recover the performance of both globally asymptotic stabilizers and L2 disturbance attenuators. Then, a new dynamic output feedback power-level control strategy is established, which is composed of this observer and the well-built static state-feedback power-level control based upon iterative dissipation assignment (IDA-PLC. Finally, numerical simulation results show the high performance and feasibility of this newly-built dynamic output feedback power-level controller.

  17. Activation of TGF-β1-CD147 positive feedback loop in hepatic stellate cells promotes liver fibrosis.

    Science.gov (United States)

    Li, Hai-Yan; Ju, Di; Zhang, Da-Wei; Li, Hao; Kong, Ling-Min; Guo, Yanhai; Li, Can; Wang, Xi-Long; Chen, Zhi-Nan; Bian, Huijie

    2015-11-12

    Activation of hepatic stellate cells (HSCs) by transforming growth factor-β1 (TGF-β1) initiates HBV-associated fibrogenesis. The mechanism of TGF-β1 modulating HSC activation is not fully uncovered. We hypothesized a positive feedback signaling loop of TGF-β1-CD147 promoting liver fibrogenesis by activation of HSCs. Human HSC cell line LX-2 and spontaneous liver fibrosis model derived from HBV transgenic mice were used to evaluate the activation of molecules in the signaling loop. Wound healing and cell contraction assay were performed to detect the CD147-overexpressed HSC migration and contraction. The transcriptional regulation of CD147 by TGF-β1/Smad4 was determined using dual-luciferase reporter assay and chromatin immunoprecipitation. We found that a positive reciprocal regulation between TGF-β1 and CD147 mediated HSC activation. CD147 over-expression promoted HSC migration and accelerated TGF-β1-induced cell contraction. Phosphorylation of Smad2 and Smad3 in cooperation with Smad4 mediated the TGF-β1-regulated CD147 expression. Smad4 activated the transcription by direct interaction with CD147 promoter. Meanwhile, CD147 modulated the activated phenotype of HSCs through the ERK1/2 and Sp1 which up-regulated α-SMA, collagen I, and TGF-β1 synthesis. These findings indicate that TGF-β1-CD147 loop plays a key role in regulating the HSC activation and combination of TGF-β receptor inhibitor and anti-CD147 antibody might be promised to reverse fibrogenesis.

  18. Computational investigation of feedback loop as a potential source of neuromechanical wave speed discrepancy in swimming animals

    Science.gov (United States)

    Patel, Namu; Patankar, Neelesh A.

    2017-11-01

    Aquatic locomotion relies on feedback loops to generate the flexural muscle moment needed to attain the reference shape. Experimentalists have consistently reported a difference between the electromyogram (EMG) and curvature wave speeds. The EMG wave speed has been found to correlate with the cross-sectional moment wave. The correlation, however, remains unexplained. Using feedback dependent controller models, we demonstrate two scenarios - one at higher passive elastic stiffness and another at lower passive elastic stiffness of the body. The former case becomes equivalent to the penalty type mathematical model for swimming used in prior literature and it does not reproduce neuromechanical wave speed discrepancy. The latter case at lower elastic stiffness does reproduce the wave speed discrepancy and appears to be biologically most relevant. These findings are applied to develop testable hypotheses about control mechanisms that animals might be using at during low and high Reynolds number swimming. This work is supported by NSF Grants DMS-1547394, CBET-1066575, ACI-1460334, and IOS-1456830. Travel for NP is supported by Institute for Defense Analyses.

  19. The interplay of multiple feedback loops with post-translational kinetics results in bistability of mycobacterial stress response

    International Nuclear Information System (INIS)

    Tiwari, Abhinav; Igoshin, Oleg A; Balázsi, Gábor; Gennaro, Maria Laura

    2010-01-01

    Bacterial persistence is the phenomenon in which a genetically identical fraction of a bacterial population can survive exposure to stress by reduction or cessation of growth. Persistence in mycobacteria has been recently linked to a stress-response network, consisting of the MprA/MprB two-component system and alternative sigma factor σ E . This network contains multiple positive transcriptional feedback loops which may give rise to bistability, making it a good candidate for controlling the mycobacterial persistence switch. To analyze the possibility of bistability, we develop a method that involves decoupling of the network into transcriptional and post-translational interaction modules. As a result we reduce the dimensionality of the dynamical system and independently analyze input–output relations in the two modules to formulate a necessary condition for bistability in terms of their logarithmic gains. We show that neither the positive autoregulation in the MprA/MprB network nor the σ E -mediated transcriptional feedback is sufficient to induce bistability in a biochemically realistic parameter range. Nonetheless, inclusion of the post-translational regulation of σ E by RseA increases the effective cooperativity of the system, resulting in bistability that is robust to parameter variation. We predict that overexpression or deletion of RseA, the key element controlling the ultrasensitive response, can eliminate bistability

  20. The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling.

    Science.gov (United States)

    Khan, Sumbul Jawed; Abidi, Syeda Nayab Fatima; Skinner, Andrea; Tian, Yuan; Smith-Bolton, Rachel K

    2017-07-01

    Regenerating tissue must initiate the signaling that drives regenerative growth, and sustain that signaling long enough for regeneration to complete. How these key signals are sustained is unclear. To gain a comprehensive view of the changes in gene expression that occur during regeneration, we performed whole-genome mRNAseq of actively regenerating tissue from damaged Drosophila wing imaginal discs. We used genetic tools to ablate the wing primordium to induce regeneration, and carried out transcriptional profiling of the regeneration blastema by fluorescently labeling and sorting the blastema cells, thus identifying differentially expressed genes. Importantly, by using genetic mutants of several of these differentially expressed genes we have confirmed that they have roles in regeneration. Using this approach, we show that high expression of the gene moladietz (mol), which encodes the Duox-maturation factor NIP, is required during regeneration to produce reactive oxygen species (ROS), which in turn sustain JNK signaling during regeneration. We also show that JNK signaling upregulates mol expression, thereby activating a positive feedback signal that ensures the prolonged JNK activation required for regenerative growth. Thus, by whole-genome transcriptional profiling of regenerating tissue we have identified a positive feedback loop that regulates the extent of regenerative growth.

  1. A prototype framework for models of socio-hydrology: identification of key feedback loops and parameterisation approach

    Science.gov (United States)

    Elshafei, Y.; Sivapalan, M.; Tonts, M.; Hipsey, M. R.

    2014-06-01

    It is increasingly acknowledged that, in order to sustainably manage global freshwater resources, it is critical that we better understand the nature of human-hydrology interactions at the broader catchment system scale. Yet to date, a generic conceptual framework for building models of catchment systems that include adequate representation of socioeconomic systems - and the dynamic feedbacks between human and natural systems - has remained elusive. In an attempt to work towards such a model, this paper outlines a generic framework for models of socio-hydrology applicable to agricultural catchments, made up of six key components that combine to form the coupled system dynamics: namely, catchment hydrology, population, economics, environment, socioeconomic sensitivity and collective response. The conceptual framework posits two novel constructs: (i) a composite socioeconomic driving variable, termed the Community Sensitivity state variable, which seeks to capture the perceived level of threat to a community's quality of life, and acts as a key link tying together one of the fundamental feedback loops of the coupled system, and (ii) a Behavioural Response variable as the observable feedback mechanism, which reflects land and water management decisions relevant to the hydrological context. The framework makes a further contribution through the introduction of three macro-scale parameters that enable it to normalise for differences in climate, socioeconomic and political gradients across study sites. In this way, the framework provides for both macro-scale contextual parameters, which allow for comparative studies to be undertaken, and catchment-specific conditions, by way of tailored "closure relationships", in order to ensure that site-specific and application-specific contexts of socio-hydrologic problems can be accommodated. To demonstrate how such a framework would be applied, two socio-hydrological case studies, taken from the Australian experience, are presented

  2. The impact of short-term heat storage on the ice-albedo feedback loop

    Science.gov (United States)

    Polashenski, C.; Wright, N.; Perovich, D. K.; Song, A.; Deeb, E. J.

    2016-12-01

    The partitioning of solar energy in the ice-ocean-atmosphere environment is a powerful control over Arctic sea ice mass balance. Ongoing transitions of the sea ice toward a younger, thinner state are enhancing absorption of solar energy and contributing to further declines in sea ice in a classic ice-albedo feedback. Here we investigate the solar energy balance over shorter timescales. In particular, we are concerned with short term delays in the transfer of absorbed solar energy to the ice caused by heat storage in the upper ocean. By delaying the realization of ice melt, and hence albedo decline, heat storage processes effectively retard the intra-season ice-albedo feedback. We seek to quantify the impact and variability of such intra-season storage delays on full season energy absorption. We use in-situ data collected from Arctic Observing Network (AON) sea ice sites, synthesized with the results of imagery processed from high resolution optical satellites, and basin-scale remote sensing products to approach the topic. AON buoys are used to monitor the storage and flux of heat, while satellite imagery allows us to quantify the evolution of surrounding ice conditions and predict the aggregate scale solar absorption. We use several test sites as illustrative cases and demonstrate that temporary heat storage can have substantial impacts on seasonal energy absorption and ice loss. A companion to this work is presented by N. Wright at this meeting.

  3. Autonomous Closed-Loop Tasking, Acquisition, Processing, and Evaluation for Situational Awareness Feedback

    Science.gov (United States)

    Frye, Stuart; Mandl, Dan; Cappelaere, Pat

    2016-01-01

    This presentation describes the closed loop satellite autonomy methods used to connect users and the assets on Earth Orbiter- 1 (EO-1) and similar satellites. The base layer is a distributed architecture based on Goddard Mission Services Evolution Concept (GMSEC) thus each asset still under independent control. Situational awareness is provided by a middleware layer through common Application Programmer Interface (API) to GMSEC components developed at GSFC. Users setup their own tasking requests, receive views into immediate past acquisitions in their area of interest, and into future feasibilities for acquisition across all assets. Automated notifications via pubsub feeds are returned to users containing published links to image footprints, algorithm results, and full data sets. Theme-based algorithms are available on-demand for processing.

  4. A Compact Ionic Polymer Metal Composite (IPMC System with Inductive Sensor for Closed Loop Feedback

    Directory of Open Access Journals (Sweden)

    Jiaqi Wang

    2015-05-01

    Full Text Available Ionic polymer metal composite (IPMC, of which a low actuating voltage (<5 V, high power efficiency and biocompatibility makes it a proven candidate for low power devices. However, due to its inherent nonlinear behaviour and time-variance, feedback control, as well as reliable sensing means, are required for accurate operations. This paper presents an IPMC actuator implemented with an inductive sensor to enhance the reliability and compactness of the overall device. A practical, low cost and importantly, compact inductive sensor fabricated on a printed circuit board (PCB is proposed here. Target material selections and coil design considerations are discussed. It is experimentally determined that the inductive sensor has comparable performance to a laser sensor. Based on a proportional-integral-derivative (PID control results the inductive sensor has demonstrated to be an alternative to a laser sensor allowing devices using IPMC actuators to be compact.

  5. The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes

    NARCIS (Netherlands)

    Bach, Frances C; Rutten, Kirsten; Hendriks, Kristyanne; Riemers, Frank M; Cornelissen, Peter; de Bruin, Alain; Arkesteijn, Ger J; Wubbolts, Richard; Horton, William A; Penning, Louis C; Tryfonidou, Marianna A

    2014-01-01

    The endocrine feedback loop between vitamin D3(1,25(OH)2D3) and parathyroid hormone (PTH) plays a central role in skeletal development. PTH-related protein (PTHrP) shares homology and its receptor (PTHR1) with PTH. The aim of this study was to investigate whether there is a functional paracrine

  6. Micro-phonics analysis and compensation with a feedback loop at low cavity gradient

    International Nuclear Information System (INIS)

    Luong, M.; Devanz, G.; Jacques, E.; Novo, J.; Neumann, A.; Kugeler, O.

    2007-10-01

    For FEL projects based on a superconducting linac operating in continuous wave (CW) mode, the RF power optimization finally comes up against the micro-phonics disturbances, which result in an unpredictable detuning of the cavities. A new piezoelectric tuner was developed and mounted on a TTF 9-cells cavity with an appropriate instrumentation. This system enables a full characterization of the disturbances and the tuner behavior. The experimental results pointed out 3 distinct regimes of perturbation: a strong but quickly damped very low frequency oscillation due to cryogenic control, a quasi-stationary oscillation around 50 and 100 Hz due to the operation of vacuum pumps motor and some lower amplitudes oscillations related to the excitation of the mechanical structure Eigenmodes by environmental noise. Modeling, simulations and experimental validations were carried out to demonstrate the feasibility of a feedback compensation for a multi-cell cavity. The results also bring to some recommendations that may overcome the limitations pointed out in the present experimentation

  7. An Efficient Expert System Generator for Qualitative Feed-Back Loop Analysis

    Directory of Open Access Journals (Sweden)

    Manoj Kumar Jain

    2012-04-01

    Full Text Available Quite often the variables used in system analysis are qualitative in nature. They cannot be defined precisely, whereas software development for system analysis needs a mathematical framework with precise computations. It is not trivial to capture the uncertainty in the system.
    Fuzzy sets provide us the facility to capture the uncertainty in the system. In normal crisp set where the membership of an element is always certain in a sense that it would be member or not of the given set. In contrast to this a membership functions or possibility (ranging from 0 to 1, including both values is assigned with each member. System analysis is done through system dynamics which is not very efficient. We present an efficient technique to generate expert system using fuzzy set. In our proposed approach five linguistic qualifiers are used for each variable, namely, Very Low (VL, Low (L, Medium (M, High (H, and Very High
    (VH. We capture the influence or feedback in the system with the help of if then else rules and matrices are generated for them which are used for analysis. Complete methodology and its applicability are presented here.

  8. Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1.

    Directory of Open Access Journals (Sweden)

    Shinya Nakamura

    Full Text Available Trimethylation of histone H3 lysine 4 and lysine 27 (H3K4me3 and H3K27me3 at gene promoter regions critically regulates gene expression. Key developmental genes tend to exhibit changes in histone modification patterns from the H3K4me3/H3K27me3 bivalent pattern to the H3K4me3 monovalent pattern. Using comprehensive chromatin immunoprecipitation followed by sequencing in bone marrow-derived macrophages (BMMs and mature osteoclasts, we found that cell surface adhesion molecule 1 (Cadm1 is a direct target of nuclear factor of activated T cells 1 (NFATc1 and exhibits a bivalent histone pattern in BMMs and a monovalent pattern in osteoclasts. Cadm1 expression was upregulated in BMMs by receptor activator of nuclear factor kappa B ligand (RANKL, and blocked by a calcineurin/NFATc1 inhibitor, FK506. Cadm1-deficient mice exhibited significantly reduced bone mass compared with wild-type mice, which was due to the increased osteoclast differentiation, survival and bone-resorbing activity in Cadm1-deficient osteoclasts. These results suggest that Cadm1 is a direct target of NFATc1, which is induced by RANKL through epigenetic modification, and regulates osteoclastic bone resorption in a negative feedback manner.

  9. MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells.

    Directory of Open Access Journals (Sweden)

    Richard Moore

    2015-12-01

    Full Text Available The p53 tumor suppressor protein plays a critical role in cellular stress and cancer prevention. A number of post-transcriptional regulators, termed microRNAs, are closely connected with the p53-mediated cellular networks. While the molecular interactions among p53 and microRNAs have emerged, a systems-level understanding of the regulatory mechanism and the role of microRNAs-forming feedback loops with the p53 core remains elusive. Here we have identified from literature that there exist three classes of microRNA-mediated feedback loops revolving around p53, all with the nature of positive feedback coincidentally. To explore the relationship between the cellular performance of p53 with the microRNA feedback pathways, we developed a mathematical model of the core p53-MDM2 module coupled with three microRNA-mediated positive feedback loops involving miR-192, miR-34a, and miR-29a. Simulations and bifurcation analysis in relationship to extrinsic noise reproduce the oscillatory behavior of p53 under DNA damage in single cells, and notably show that specific microRNA abrogation can disrupt the wild-type cellular phenotype when the ubiquitous cell-to-cell variability is taken into account. To assess these in silico results we conducted microRNA-perturbation experiments in MCF7 breast cancer cells. Time-lapse microscopy of cell-population behavior in response to DNA double-strand breaks, together with image classification of single-cell phenotypes across a population, confirmed that the cellular p53 oscillations are compromised after miR-192 perturbations, matching well with the model predictions. Our study via modeling in combination with quantitative experiments provides new evidence on the role of microRNA-mediated positive feedback loops in conferring robustness to the system performance of stress-induced response of p53.

  10. The calcium feedback loop and T cell activation: how cytoskeleton networks control intracellular calcium flux.

    Science.gov (United States)

    Joseph, Noah; Reicher, Barak; Barda-Saad, Mira

    2014-02-01

    During T cell activation, the engagement of a T cell with an antigen-presenting cell (APC) results in rapid cytoskeletal rearrangements and a dramatic increase of intracellular calcium (Ca(2+)) concentration, downstream to T cell antigen receptor (TCR) ligation. These events facilitate the organization of an immunological synapse (IS), which supports the redistribution of receptors, signaling molecules and organelles towards the T cell-APC interface to induce downstream signaling events, ultimately supporting T cell effector functions. Thus, Ca(2+) signaling and cytoskeleton rearrangements are essential for T cell activation and T cell-dependent immune response. Rapid release of Ca(2+) from intracellular stores, e.g. the endoplasmic reticulum (ER), triggers the opening of Ca(2+) release-activated Ca(2+) (CRAC) channels, residing in the plasma membrane. These channels facilitate a sustained influx of extracellular Ca(2+) across the plasma membrane in a process termed store-operated Ca(2+) entry (SOCE). Because CRAC channels are themselves inhibited by Ca(2+) ions, additional factors are suggested to enable the sustained Ca(2+) influx required for T cell function. Among these factors, we focus here on the contribution of the actin and microtubule cytoskeleton. The TCR-mediated increase in intracellular Ca(2+) evokes a rapid cytoskeleton-dependent polarization, which involves actin cytoskeleton rearrangements and microtubule-organizing center (MTOC) reorientation. Here, we review the molecular mechanisms of Ca(2+) flux and cytoskeletal rearrangements, and further describe the way by which the cytoskeletal networks feedback to Ca(2+) signaling by controlling the spatial and temporal distribution of Ca(2+) sources and sinks, modulating TCR-dependent Ca(2+) signals, which are required for an appropriate T cell response. This article is part of a Special Issue entitled: Reciprocal influences between cell cytoskeleton and membrane channels, receptors and transporters

  11. In vivo Microscale Measurements of Light and Photosynthesis during Coral Bleaching: Evidence for the Optical Feedback Loop?

    Science.gov (United States)

    Wangpraseurt, Daniel; Holm, Jacob B; Larkum, Anthony W D; Pernice, Mathieu; Ralph, Peter J; Suggett, David J; Kühl, Michael

    2017-01-01

    Climate change-related coral bleaching, i.e., the visible loss of zooxanthellae from the coral host, is increasing in frequency and extent and presents a major threat to coral reefs globally. Coral bleaching has been proposed to involve accelerating light stress of their microalgal endosymbionts via a positive feedback loop of photodamage, symbiont expulsion and excess in vivo light exposure. To test this hypothesis, we used light and O 2 microsensors to characterize in vivo light exposure and photosynthesis of Symbiodinium during a thermal stress experiment. We created tissue areas with different densities of Symbiodinium cells in order to understand the optical properties and light microenvironment of corals during bleaching. Our results showed that in bleached Pocillopora damicornis corals, Symbiodinium light exposure was up to fivefold enhanced relative to healthy corals, and the relationship between symbiont loss and light enhancement was well-described by a power-law function. Cell-specific rates of Symbiodinium gross photosynthesis and light respiration were enhanced in bleached P. damicornis compared to healthy corals, while areal rates of net photosynthesis decreased. Symbiodinium light exposure in Favites sp. revealed the presence of low light microniches in bleached coral tissues, suggesting that light scattering in thick coral tissues can enable photoprotection of cryptic symbionts. Our study provides evidence for the acceleration of in vivo light exposure during coral bleaching but this optical feedback mechanism differs between coral hosts. Enhanced photosynthesis in relation to accelerating light exposure shows that coral microscale optics exerts a key role on coral photophysiology and the subsequent degree of radiative stress during coral bleaching.

  12. Numerical comparison of thermal hydraulic aspects of supercritical carbon dioxide and subcritical water-based natural circulation loop

    Energy Technology Data Exchange (ETDEWEB)

    Sarkar, Milan Krishna Singhar; Basu, Dipankar Narayan [Dept. of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati (India)

    2017-02-15

    Application of the supercritical condition in reactor core cooling needs to be properly justified based on the extreme level of parameters involved. Therefore, a numerical study is presented to compare the thermalhydraulic performance of supercritical and single-phase natural circulation loops under low-to-intermediate power levels. Carbon dioxide and water are selected as respective working fluids, operating under an identical set of conditions. Accordingly, a three-dimensional computational model was developed, and solved with an appropriate turbulence model and equations of state. Large asymmetry in velocity and temperature profiles was observed in a single cross section due to local buoyancy effect, which is more prominent for supercritical fluids. Mass flow rate in a supercritical loop increases with power until a maximum is reached, which subsequently corresponds to a rapid deterioration in heat transfer coefficient. That can be identified as the limit of operation for such loops to avoid a high temperature, and therefore, the use of a supercritical loop is suggested only until the appearance of such maxima. Flow-induced heat transfer deterioration can be delayed by increasing system pressure or lowering sink temperature. Bulk temperature level throughout the loop with water as working fluid is higher than supercritical carbon dioxide. This is until the heat transfer deterioration, and hence the use of a single-phase loop is prescribed beyond that limit.

  13. Leukemia Mediated Endothelial Cell Activation Modulates Leukemia Cell Susceptibility to Chemotherapy through a Positive Feedback Loop Mechanism.

    Directory of Open Access Journals (Sweden)

    Bahareh Pezeshkian

    Full Text Available In acute myeloid leukemia (AML, the chances of achieving disease-free survival are low. Studies have demonstrated a supportive role of endothelial cells (ECs in normal hematopoiesis. Here we show that similar intercellular relationships exist in leukemia. We demonstrate that leukemia cells themselves initiate these interactions by directly modulating the behavior of resting ECs through the induction of EC activation. In this inflammatory state, activated ECs induce the adhesion of a sub-set of leukemia cells through the cell adhesion molecule E-selectin. These adherent leukemia cells are sequestered in a quiescent state and are unaffected by chemotherapy. The ability of adherent cells to later detach and again become proliferative following exposure to chemotherapy suggests a role of this process in relapse. Interestingly, differing leukemia subtypes modulate this process to varying degrees, which may explain the varied response of AML patients to chemotherapy and relapse rates. Finally, because leukemia cells themselves induce EC activation, we postulate a positive-feedback loop in leukemia that exists to support the growth and relapse of the disease. Together, the data defines a new mechanism describing how ECs and leukemia cells interact during leukemogenesis, which could be used to develop novel treatments for those with AML.

  14. Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation

    DEFF Research Database (Denmark)

    Rishi, Loveena; Hannon, Maura; Salomè, Mara

    2014-01-01

    α (C/EBPα)-p42, occurs in acute myeloid leukemia (AML), resulting in the perturbation of cell cycle and apoptosis, emphasizing its importance in the molecular pathogenesis of AML. Here we show that E2F family members directly regulate Trib2 in leukemic cells and identify a feedback regulatory loop......The loss of regulation of cell proliferation is a key event in leukemic transformation, and the oncogene tribbles (Trib)2 is emerging as a pivotal target of transcription factors in acute leukemias. Deregulation of the transcription factor E2F1, normally repressed by CCAAT enhancer-binding protein...... for E2F1, C/EBPα, and Trib2 in AML cell proliferation and survival. Further analyses revealed that E2F1-mediated Trib2 expression was repressed by C/EBPα-p42, and in normal granulocyte/macrophage progenitor cells, we detect C/EBPα bound to the Trib2 promoter. Pharmacological inhibition of the cell cycle...

  15. Mathematical Modeling of the Pituitary-Thyroid Feedback Loop: Role of a TSH-T3-Shunt and Sensitivity Analysis.

    Science.gov (United States)

    Berberich, Julian; Dietrich, Johannes W; Hoermann, Rudolf; Müller, Matthias A

    2018-01-01

    Despite significant progress in assay technology, diagnosis of functional thyroid disorders may still be a challenge, as illustrated by the vague upper limit of the reference range for serum thyrotropin ( TSH ). Diagnostical problems also apply to subjects affected by syndrome T, i.e., those 10% of hypothyroid patients who continue to suffer from poor quality of life despite normal TSH concentrations under substitution therapy with levothyroxine ( L - T 4 ). In this paper, we extend a mathematical model of the pituitary-thyroid feedback loop in order to improve the understanding of thyroid hormone homeostasis. In particular, we incorporate a TSH - T 3 -shunt inside the thyroid, whose existence has recently been demonstrated in several clinical studies. The resulting extended model shows good accordance with various clinical observations, such as a circadian rhythm in free peripheral triiodothyronine ( FT 3 ). Furthermore, we perform a sensitivity analysis of the derived model, revealing the dependence of TSH and hormone concentrations on different system parameters. The results have implications for clinical interpretation of thyroid tests, e.g., in the differential diagnosis of subclinical hypothyroidism.

  16. Positive feedback loop between introductions of non-native marine species and cultivation of oysters in Europe.

    Science.gov (United States)

    Mineur, Frederic; Le Roux, Auguste; Maggs, Christine A; Verlaque, Marc

    2014-12-01

    With globalization, agriculture and aquaculture activities are increasingly affected by diseases that are spread through movement of crops and stock. Such movements are also associated with the introduction of non-native species via hitchhiking individual organisms. The oyster industry, one of the most important forms of marine aquaculture, embodies these issues. In Europe disease outbreaks affecting cultivated populations of the naturalized oyster Crassostrea gigas caused a major disruption of production in the late 1960s and early 1970s. Mitigation procedures involved massive imports of stock from the species' native range in the northwestern Pacific from 1971 to 1977. We assessed the role stock imports played in the introduction of non-native marine species (including pathogens) from the northwestern Pacific to Europe through a methodological and critical appraisal of record data. The discovery rate of non-native species (a proxy for the introduction rate) from 1966 to 2012 suggests a continuous vector activity over the entire period. Disease outbreaks that have been affecting oyster production since 2008 may be a result of imports from the northwestern Pacific, and such imports are again being considered as an answer to the crisis. Although successful as a remedy in the short and medium terms, such translocations may bring new diseases that may trigger yet more imports (self-reinforcing or positive feedback loop) and lead to the introduction of more hitchhikers. Although there is a legal framework to prevent or reduce these introductions, existing procedures should be improved. © 2014 Society for Conservation Biology.

  17. Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation.

    LENUS (Irish Health Repository)

    Rishi, Loveena

    2014-04-10

    The loss of regulation of cell proliferation is a key event in leukemic transformation, and the oncogene tribbles (Trib)2 is emerging as a pivotal target of transcription factors in acute leukemias. Deregulation of the transcription factor E2F1, normally repressed by CCAAT enhancer-binding protein α (C\\/EBPα)-p42, occurs in acute myeloid leukemia (AML), resulting in the perturbation of cell cycle and apoptosis, emphasizing its importance in the molecular pathogenesis of AML. Here we show that E2F family members directly regulate Trib2 in leukemic cells and identify a feedback regulatory loop for E2F1, C\\/EBPα, and Trib2 in AML cell proliferation and survival. Further analyses revealed that E2F1-mediated Trib2 expression was repressed by C\\/EBPα-p42, and in normal granulocyte\\/macrophage progenitor cells, we detect C\\/EBPα bound to the Trib2 promoter. Pharmacological inhibition of the cell cycle or Trib2 knockdown resulted in a block in AML cell proliferation. Our work proposes a novel paradigm whereby E2F1 plays a key role in the regulation of Trib2 expression important for AML cell proliferation control. Importantly, we identify the contribution of dysregulated C\\/EBPα and E2F1 to elevated Trib2 expression and leukemic cell survival, which likely contributes to the initiation and maintenance of AML and may have significant implications for normal and malignant hematopoiesis.

  18. Individualising Media Practice Education Using a Feedback Loop and Instructional Videos Within an eLearning Environment.

    Directory of Open Access Journals (Sweden)

    Trevor Harris

    2012-06-01

    Full Text Available This paper explores the development and impact of the author’s TELE (Technology Enhanced Learning Environment action research project for individualising media practice education. The latest iteration of different classroom methodologies being employed to develop high-level skills in media production, the author has combined an interactive eLearning approach with instructional videos and, crucially, an individual feedback loop in order to widen access to the curriculum and create a more efficient teaching and learning environment. The focus therefore is on student engagement and organisational efficiencies as a result of the research. It should be noted that there has been no funding attached to this work, nor are there any institutional imperatives or other stakeholder involvement in this research. This project has been undertaken by the author as an evolutionary development of the various methodologies developed, cognisant of the increased technology literacy of the student cohort. The educational benefit of bringing video instruction into the curriculum as part of the project is examined as a creative pedagogy of direct benefit to students rather than as a subliminal marketing tool that other systems are often used for. Over 16K words of written data was collected during the project, and this is analysed both quantitatively and qualitatively with reference to the initial objectives of the research

  19. Mathematical Modeling of the Pituitary–Thyroid Feedback Loop: Role of a TSH-T3-Shunt and Sensitivity Analysis

    Directory of Open Access Journals (Sweden)

    Julian Berberich

    2018-03-01

    Full Text Available Despite significant progress in assay technology, diagnosis of functional thyroid disorders may still be a challenge, as illustrated by the vague upper limit of the reference range for serum thyrotropin (TSH. Diagnostical problems also apply to subjects affected by syndrome T, i.e., those 10% of hypothyroid patients who continue to suffer from poor quality of life despite normal TSH concentrations under substitution therapy with levothyroxine (L-T4. In this paper, we extend a mathematical model of the pituitary–thyroid feedback loop in order to improve the understanding of thyroid hormone homeostasis. In particular, we incorporate a TSH-T3-shunt inside the thyroid, whose existence has recently been demonstrated in several clinical studies. The resulting extended model shows good accordance with various clinical observations, such as a circadian rhythm in free peripheral triiodothyronine (FT3. Furthermore, we perform a sensitivity analysis of the derived model, revealing the dependence of TSH and hormone concentrations on different system parameters. The results have implications for clinical interpretation of thyroid tests, e.g., in the differential diagnosis of subclinical hypothyroidism.

  20. Mathematical Modeling of the Pituitary–Thyroid Feedback Loop: Role of a TSH-T3-Shunt and Sensitivity Analysis

    Science.gov (United States)

    Berberich, Julian; Dietrich, Johannes W.; Hoermann, Rudolf; Müller, Matthias A.

    2018-01-01

    Despite significant progress in assay technology, diagnosis of functional thyroid disorders may still be a challenge, as illustrated by the vague upper limit of the reference range for serum thyrotropin (TSH). Diagnostical problems also apply to subjects affected by syndrome T, i.e., those 10% of hypothyroid patients who continue to suffer from poor quality of life despite normal TSH concentrations under substitution therapy with levothyroxine (L-T4). In this paper, we extend a mathematical model of the pituitary–thyroid feedback loop in order to improve the understanding of thyroid hormone homeostasis. In particular, we incorporate a TSH-T3-shunt inside the thyroid, whose existence has recently been demonstrated in several clinical studies. The resulting extended model shows good accordance with various clinical observations, such as a circadian rhythm in free peripheral triiodothyronine (FT3). Furthermore, we perform a sensitivity analysis of the derived model, revealing the dependence of TSH and hormone concentrations on different system parameters. The results have implications for clinical interpretation of thyroid tests, e.g., in the differential diagnosis of subclinical hypothyroidism. PMID:29619006

  1. Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop

    International Nuclear Information System (INIS)

    Lai, Serene R.; Cunningham, Amanda P.; Huynh, Vu Q.; Andrews, Lucy G.; Tollefsbol, Trygve O.

    2007-01-01

    The human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the enzyme telomerase which is responsible for telomeric maintenance and extension. Using RNA interference to knock down hTERT mRNA expression, we provide evidence that hTERT exerts extra-telomeric effects on the cell cycle and on its own regulatory proteins, specifically: p53 and p21. We tested our hypothesis that hTERT regulates its own expression through effects on upstream regulatory genes using transformed human embryonic kidney (HEK 293) cells, p53 and p16 INK4a null human ovarian cancer SKOV-3 cells, and p53-null MDA-MB-157 human mammary cancer cells. In HEK 293 cells, hTERT knockdown resulted in elevated p53 and p21 transcription and a decrease in cellular proliferation. Similar results were observed in the MDA-MB-157 cell line where p21 was upregulated, correlating with cell growth inhibition. In contrast, we observed a decrease in expression of p21 in SKOV-3 cells with hTERT knockdown and cell growth appeared to be unaffected. These findings suggest that hTERT may be involved in a feedback loop system, thereby playing a role in its own regulation

  2. Healthy Change Processes-A Diary Study of Five Organizational Units. Establishing a Healthy Change Feedback Loop.

    Science.gov (United States)

    Lien, Mathilde; Saksvik, Per Øystein

    2016-10-01

    This paper explores a change process in the Central Norway Regional Health Authority that was brought about by the implementation of a new economics and logistics system. The purpose of this paper is to contribute to understanding of how employees' attitudes towards change develop over time and how attitudes differ between the five health trusts under this authority. In this paper, we argue that a process-oriented focus through a longitudinal diary method, in addition to action research and feedback loops, will provide greater understanding of the evaluation of organizational change and interventions. This is explored through the assumption that different units will have different perspectives and attitudes towards the same intervention over time because of different contextual and time-related factors. The diary method aims to capture the context, events, reflections and interactions when they occur and allows for a nuanced frame of reference for the different phases of the implementation process and how these phases are perceived by employees. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  3. Modeling the interaction of a heavily beam loaded SRF cavity with its low-level RF feedback loops

    Science.gov (United States)

    Liu, Zong-Kai; Wang, Chaoen; Chang, Lung-Hai; Yeh, Meng-Shu; Chang, Fu-Yu; Chang, Mei-Hsia; Chang, Shian-Wen; Chen, Ling-Jhen; Chung, Fu-Tsai; Lin, Ming-Chyuan; Lo, Chih-Hung; Yu, Tsung-Chi

    2018-06-01

    A superconducting radio frequency (SRF) cavity provides superior stability to power high intensity light sources and can suppress coupled-bunch instabilities due to its smaller impedance for higher order modes. Because of these features, SRF cavities are commonly used for modern light sources, such as the TLS, CLS, DLS, SSRF, PLS-II, TPS, and NSLS-II, with an aggressive approach to operate the light sources at high beam currents. However, operating a SRF cavity at high beam currents may result with unacceptable stability problems of the low level RF (LLRF) system, due to drifts of the cavity resonant frequency caused by unexpected perturbations from the environment. As the feedback loop gets out of control, the cavity voltage may start to oscillate with a current-dependent characteristic frequency. Such situations can cause beam abort due to the activation of the interlock protection system, i.e. false alarm of quench detection. This malfunction of the light source reduces the reliability of SRF operation. Understanding this unstable mechanism to prevent its appearance becomes a primary task in the pursuit of highly reliable SRF operation. In this paper, a Pedersen model, including the response of the LLRF system, was used to simulate the beam-cavity interaction of a SRF cavity under heavy beam loading. Causes for the onset of instability at high beam current will be discussed as well as remedies to assure the design of a stable LLRF system.

  4. LncRNA FIRRE/NF-kB feedback loop contributes to OGD/R injury of cerebral microglial cells.

    Science.gov (United States)

    Zang, Yunhua; Zhou, Xiyan; Wang, Qun; Li, Xia; Huang, Hailiang

    2018-04-28

    Stroke is one of the leading causes for serious long-term neurological disability. LncRNAs have been investigated to be dysregulated in ischemic stroke. However, the underlying mechanisms of some specific lncRNAs have not been clearly clarified. To determine lncRNA-mediated regulatory mechanism in ischemic stroke, we constructed OGD/R injury model of cerebral microglial cells. Microarray analysis was carried out and analyzed that lncRNA functional intergenic repeating RNA element (FIRRE) was associated with OGD/R injury. Based on the molecular biotechnology, we demonstrated that FIRRE could activate NF-kB signal pathway. Meanwhile, the activated NF-kB promoted FIRRE expression in OGD/R-treated cerebral microglial cells. Therefore, FIRRE and NF-kB formed a positive feedback loop to promote the transcription of NLRP3 inflammasome, thus contributed to the OGD/R injury of cerebral microglial cells. All findings in this study may help to explore novel and specific therapeutic target for ischemic stroke. Copyright © 2018. Published by Elsevier Inc.

  5. RTVP-1 promotes mesenchymal transformation of glioma via a STAT-3/IL-6-dependent positive feedback loop

    Science.gov (United States)

    Giladi, Nis David; Ziv-Av, Amotz; Lee, Hae Kyung; Finniss, Susan; Cazacu, Simona; Xiang, Cunli; Ben-Asher, Hiba Waldman; deCarvalho, Ana; Mikkelsen, Tom; Poisson, Laila; Brodie, Chaya

    2015-01-01

    Glioblastomas (GBMs), the most aggressive primary brain tumors, exhibit increased invasiveness and resistance to anti-tumor treatments. We explored the role of RTVP-1, a glioma-associated protein that promotes glioma cell migration, in the mesenchymal transformation of GBM. Analysis of The Cancer Genome Atlas (TCGA) demonstrated that RTVP-1 expression was higher in mesenchymal GBM and predicted tumor recurrence and poor clinical outcome. ChiP analysis revealed that the RTVP-1 promoter binds STAT3 and C/EBPβ, two master transcription factors that regulate mesenchymal transformation of GBM. In addition, IL-6 induced RTVP-1 expression in a STAT3-dependent manner. RTVP-1 increased the migration and mesenchymal transformation of glioma cells. Similarly, overexpression of RTVP-1 in human neural stem cells induced mesenchymal differentiation, whereas silencing of RTVP-1 in glioma stem cells (GSCs) decreased the mesenchymal transformation and stemness of these cells. Silencing of RTVP-1 also increased the survival of mice bearing GSC-derived xenografts. Using gene array analysis of RTVP-1 silenced glioma cells we identified IL-6 as a mediator of RTVP-1 effects on the mesenchymal transformation and migration of GSCs, therefore acting in a positive feedback loop by upregulating RTVP-1 expression via the STAT3 pathway. Collectively, these results implicate RTVP-1 as a novel prognostic marker and therapeutic target in GBM. PMID:26267319

  6. Thermal-hydraulic oscillations in a low pressure two-phase natural circulation loop at low powers and high inlet subcoolings

    International Nuclear Information System (INIS)

    Wang, S.B.; Wu, J.Y.; Chin Pan; Lin, W.K.

    2004-01-01

    The stability of a natural circulation boiling loop is of great importance and interests for both academic researches and many industrial applications, such as next generation boiling water reactors. The present study investigated the thermal-hydraulic oscillation behavior in a low pressure two-phase natural circulation loop at low powers and high inlet subcoolings. The experiments were conducted at atmospheric pressure with heating power ranging from 4 to 8 kW and inlet subcooling ranging from 27 to 75 deg. C. Significant oscillations in loop mass flow rate, pressure drop in each section, and heated wall and fluid temperatures are present for all the cases studied here. The oscillation is typically quasi-periodic and with flow reversal with magnitudes smaller than forward flows. The magnitude of wall temperature oscillation could be as high as 60 deg. C, which will be of serious concern for practical applications. It is found that the first fundamental oscillation (large magnitude oscillation) frequency increases with increase in heated power and with decrease in inlet subcooling. (author)

  7. Q-factor enhancement for self-actuated self-sensing piezoelectric MEMS resonators applying a lock-in driven feedback loop

    International Nuclear Information System (INIS)

    Kucera, M; Bittner, A; Schmid, U; Manzaneque, T; Sánchez-Rojas, J L

    2013-01-01

    This paper presents a robust Q-control approach based on an all-electrical feedback loop enhancing the quality factor of a resonant microstructure by using the self-sensing capability of a piezoelectric thin film actuator made of aluminium nitride. A lock-in amplifier is used to extract the feedback signal which is proportional to the piezoelectric current. The measured real part is used to replace the originally low-quality and noisy feedback signal to modulate the driving voltage of the piezoelectric thin-film actuator. Since the lock-in amplifier reduces the noise in the feedback signal substantially, the proposed enhancement loop avoids the disadvantage of a constant signal-to-noise ratio, which an analogue feedback circuit usually suffers from. The quality factor was increased from the intrinsic value of 1766 to a maximum of 34 840 in air. These promising results facilitate precise measurements for self-actuated and self-sensing MEMS cantilevers even when operated in static viscous media. (paper)

  8. Positive and negative feedback loops in nutrient phytoplankton interactions related to climate dynamics factors in a shallow temperate estuary (Vistula Lagoon, southern Baltic)

    Science.gov (United States)

    Kruk, Marek; Kobos, Justyna; Nawrocka, Lidia; Parszuto, Katarzyna

    2018-04-01

    This study aims to demonstrate that factors associated with climate dynamics, such as temperature and wind, affect the ecosystem of the shallow Vistula Lagoon in the southern Baltic and cause nutrient forms phytoplankton interactions: the growth of biomass and constraints of it. This occurs through a network of direct and indirect relationships between environmental and phytoplankton factors, including interactions of positive and negative feedback loops. Path analysis supported by structural equation modeling (SEM) was used to test hypotheses regarding the impact of climate factors on algal assemblages. Increased phytoplankton biomass was affected directly by water temperature and salinity, while the wind speed effect was indirect as it resulted in increased concentrations of suspended solids (SS) in the water column. Simultaneously, the concentration of SS in the water was positively correlated with particulate organic carbon (POC), particulate nitrogen (PN), and particulate phosphorus (PP), and was negatively correlated with the total nitrogen to phosphorus (N:P) ratio. Particulate forms of C, N, and phosphorus (P), concentrations of soluble reactive phosphorus (SRP) and nitrate and nitrite nitrogen (NO3-N + NO2-N), and ratios of the total N:P and DIN:SRP, all indirectly effected Cyanobacteria C concentrations. These processes influence other phytoplankton groups (Chlorophyta, Bacillariophyceae and the picophytoplankton fraction). Increased levels of SRP associated with organic matter (POC), which stemmed from reduced DIN:SRP ratios, contributed to increased Cyanoprokaryota and picophytoplankton C concentrations, which created a positive feedback loop. However, a simultaneous reduction in the total N:P ratio could have inhibited increases in the biomass of these assemblages by limiting N, which likely formed a negative feedback loop. The study indicates that the nutrients-phytoplankton feedback loop phenomenon can intensify eutrophication in a temperate lagoon

  9. MicroRNA-Mediated Positive Feedback Loop and Optimized Bistable Switch in a Cancer Network Involving miR-17-92

    Science.gov (United States)

    Li, Yichen; Li, Yumin; Zhang, Hui; Chen, Yong

    2011-01-01

    MicroRNAs (miRNAs) are small, noncoding RNAs that play an important role in many key biological processes, including development, cell differentiation, the cell cycle and apoptosis, as central post-transcriptional regulators of gene expression. Recent studies have shown that miRNAs can act as oncogenes and tumor suppressors depending on the context. The present work focuses on the physiological significance of miRNAs and their role in regulating the switching behavior. We illustrate an abstract model of the Myc/E2F/miR-17-92 network presented by Aguda et al. (2008), which is composed of coupling between the E2F/Myc positive feedback loops and the E2F/Myc/miR-17-92 negative feedback loop. By systematically analyzing the network in close association with plausible experimental parameters, we show that, in the presence of miRNAs, the system bistability emerges from the system, with a bistable switch and a one-way switch presented by Aguda et al. instead of a single one-way switch. Moreover, the miRNAs can optimize the switching process. The model produces a diverse array of response-signal behaviors in response to various potential regulating scenarios. The model predicts that this transition exists, one from cell death or the cancerous phenotype directly to cell quiescence, due to the existence of miRNAs. It was also found that the network involving miR-17-92 exhibits high noise sensitivity due to a positive feedback loop and also maintains resistance to noise from a negative feedback loop. PMID:22022595

  10. Thermal hydraulic behavior of a PWR under beyond-design-basis accident conditions: Conclusions from an experimental program in a 4-loop test facility (PKL)

    International Nuclear Information System (INIS)

    Umminger, K.J.; Kastner, W.; Mandl, R.M.; Weber, P.

    1993-01-01

    Within the scope of German reactor safety research, extensive experiments covering the behavior of nuclear power plants under accident conditions have been carried out in the PKL test facility which simulates a 4-loop, 1,300 MWe KWU-designed PWR. While the investigations dealing with design-basis accidents and with the efficiency of the emergency core cooling systems have been largely completed, the main interest nowadays concentrates on the investigation of beyond-design-basis accidents to demonstrate the safety margins of nuclear power plants and to investigate the contribution of the built-in safety features for a further reduction of the residual risk. The thermal hydraulic behavior of a PWR under these extreme accident conditions was experimentally investigated within the PKL III B test program. This paper presents the fundamental findings with some of the most important results being discussed in detail. Future plans are also outlined

  11. Qualification of coupled 3D neutron kinetic/thermal hydraulic code systems by the calculation of a VVER-440 benchmark. Re-connection of an isolated loop

    Energy Technology Data Exchange (ETDEWEB)

    Kotsarev, Alexander; Lizorkin, Mikhail [National Research Centre ' Kurchatov Institute' , Moscow (Russian Federation); Bencik, Marek; Hadek, Jan [UJV Rez, a.s., Rez (Czech Republic); Kozmenkov, Yaroslav; Kliem, Soeren [Helmholtz-Zentrum Dresden-Rossendorf (HZDR) e.V., Dresden (Germany)

    2016-09-15

    The 7th AER dynamic benchmark is a continuation of the efforts to validate the codes systematically for the estimation of the transient behavior of VVER type nuclear power plants. The main part of the benchmark is the simulation of the re-connection of an isolated circulation loop with low temperature in a VVER-440 plant. This benchmark was calculated by the National Research Centre ''Kurchatov Institute'' (with the code ATHLET/BIPR-VVER), UJV Rez (with the code RELAP5-3D {sup copyright}) and HZDR (with the code DYN3D/ATHLET). The paper gives an overview of the behavior of the main thermal hydraulic and neutron kinetic parameters in the provided solutions.

  12. Experimental investigation of the thermal hydraulics in lead bismuth eutectic-helium experimental loop of an accelerator-driven system

    Energy Technology Data Exchange (ETDEWEB)

    Xi, Wenxuan; Wang, Yong Wei; Li, Xun Feng; Huai, Xiulan; Cal, Jun [Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing (China)

    2016-10-15

    The heat transfer characteristics between liquid lead bismuth eutectic (LBE) and helium are of great significance for the two-loop cooling system based on an accelerator-driven system (ADS). This paper presents an experimental study on the resistance characteristics and heat transfer performance in a LBE-helium experimental loop of ADS. Pressure drops in the LBE loop, the main heat transfer, and the coupled heat transfer characteristics between LBE and helium are investigated experimentally. The temperature of LBE has a significant effect on the LBE thermo-physical properties, and is therefore considered in the prediction of pressure drops. The results show that the overall heat transfer coefficient increases with the increasing helium flow rate and the decreasing inlet temperature of helium. Increasing the LBE Reynolds number and LBE inlet temperature promotes the heat transfer performance of main heat transfer and thus the overall heat transfer coefficient. The experimental results give an insight into the flow and heat transfer properties in a LBE-helium heat exchanger and are helpful for the optimization of an ADS system design.

  13. Thermo-hydraulic-mechanical analysis of the SS-050 sodium loop during a thermal shock of 2000C/s

    International Nuclear Information System (INIS)

    Jesus Miranda, C.A. de; Gebrin, A.N.

    1988-01-01

    An analytical thermo-hydraulic model was developed to obtain the temperature of the sodium flowing between the mixing tank TM of constant volume and the drain tank of the SS-050 sodium test facility. The piping connecting these two tanks is considered in the analysis. The sodium enters in the TM through a tube with lateral holes immersed in the TM's sodium. The model and relative computer program were tested and a typical situation was studied: a thermal shock with -200 0 C/s of thermal gradient in the test section. The sodium temperature time-histories along the piping length are presented. For the thermal shock situation, the temperature field in the TM bottom and outlet nozzle was calculated and the stresses were evaluated. The final thermal stresses will allow a detailed verification of the circuit design. (author) [pt

  14. Closed-loop mechanical ventilation for lung injury: a novel physiological-feedback mode following the principles of the open lung concept.

    Science.gov (United States)

    Schwaiberger, David; Pickerodt, Philipp A; Pomprapa, Anake; Tjarks, Onno; Kork, Felix; Boemke, Willehad; Francis, Roland C E; Leonhardt, Steffen; Lachmann, Burkhard

    2018-06-01

    Adherence to low tidal volume (V T ) ventilation and selected positive end-expiratory pressures are low during mechanical ventilation for treatment of the acute respiratory distress syndrome. Using a pig model of severe lung injury, we tested the feasibility and physiological responses to a novel fully closed-loop mechanical ventilation algorithm based on the "open lung" concept. Lung injury was induced by surfactant washout in pigs (n = 8). Animals were ventilated following the principles of the "open lung approach" (OLA) using a fully closed-loop physiological feedback algorithm for mechanical ventilation. Standard gas exchange, respiratory- and hemodynamic parameters were measured. Electrical impedance tomography was used to quantify regional ventilation distribution during mechanical ventilation. Automatized mechanical ventilation provided strict adherence to low V T -ventilation for 6 h in severely lung injured pigs. Using the "open lung" approach, tidal volume delivery required low lung distending pressures, increased recruitment and ventilation of dorsal lung regions and improved arterial blood oxygenation. Physiological feedback closed-loop mechanical ventilation according to the principles of the open lung concept is feasible and provides low tidal volume ventilation without human intervention. Of importance, the "open lung approach"-ventilation improved gas exchange and reduced lung driving pressures by opening atelectasis and shifting of ventilation to dorsal lung regions.

  15. Thermo-hydraulic Analysis of a Water-cooled Printed Circuit Heat Exchanger in a Small-scale Nitrogen Loop

    International Nuclear Information System (INIS)

    Kim, Chan Soo; Hong, Sung Deok; Kim, Min Hwan; Shim, Jaesool; Lee, Gyung Dong

    2013-01-01

    The development of high-temperature heat exchangers is very important because of its higher operation temperature and pressure than those of common light water reactors and industrial process plants. In particular, the intermediate heat exchanger is a key-challenged high temperature component in a Very High Temperature gas-cooled Reactor (VHTR). A printed circuit heat exchanger is one of the candidates for an intermediate heat exchanger in a VHTR. The printed circuit heat exchanger (PCHE) was developed and commercialized by HEATRIC. The compactness is better than any other heat exchanger types, because its core matrices are fabricated by diffusion bonding with photo-chemically etched micro-channels. Various tests and analysis have been performed to verify the performance of PCHE. The thermal stress analysis of the high temperature PCHE is necessary to endure the extremely operation condition of IHX. In this study, the thermo-hydraulic analysis for the laboratory-scale PCHE is performed to provide the input data for the boundary conditions of a structural analysis. The results from the first-principal calculation are compared with those from computational fluid dynamics code analysis. COMSOL 4.3a analysis is successfully performed at the uniform pressure drop condition in a set of flow channel stacks. The heat-exchanged region concentrated to the nitrogen inlet cause the uniform mass velocity distribution in the channels, therefore there is little difference between two analytical results

  16. Nonlinear control for a class of hydraulic servo system.

    Science.gov (United States)

    Yu, Hong; Feng, Zheng-jin; Wang, Xu-yong

    2004-11-01

    The dynamics of hydraulic systems are highly nonlinear and the system may be subjected to non-smooth and discontinuous nonlinearities due to directional change of valve opening, friction, etc. Aside from the nonlinear nature of hydraulic dynamics, hydraulic servo systems also have large extent of model uncertainties. To address these challenging issues, a robust state-feedback controller is designed by employing backstepping design technique such that the system output tracks a given signal arbitrarily well, and all signals in the closed-loop system remain bounded. Moreover, a relevant disturbance attenuation inequality is satisfied by the closed-loop signals. Compared with previously proposed robust controllers, this paper's robust controller based on backstepping recursive design method is easier to design, and is more suitable for implementation.

  17. Thermal-hydraulic feedback model to calculate the neutronic cross-section in PWR reactions; Modelo termohidraulico para realimentacao do calculo de secoes de choque neutronicas em reatores PWR

    Energy Technology Data Exchange (ETDEWEB)

    Santiago, Daniela Maiolino Norberto

    2011-07-01

    In neutronic codes,it is important to have a thermal-hydraulic feedback module. This module calculates the thermal-hydraulic feedback of the fuel, that feeds the neutronic cross sections. In the neutronic co de developed at PEN / COPPE / UFRJ, the fuel temperature is obtained through an empirical model. This work presents a physical model to calculate this temperature. We used the finite volume technique of discretized the equation of temperature distribution, while calculation the moderator coefficient of heat transfer, was carried out using the ASME table, and using some of their routines to our program. The model allows one to calculate an average radial temperature per node, since the thermal-hydraulic feedback must follow the conditions imposed by the neutronic code. The results were compared with to the empirical model. Our results show that for the fuel elements near periphery, the empirical model overestimates the temperature in the fuel, as compared to our model, which may indicate that the physical model is more appropriate to calculate the thermal-hydraulic feedback temperatures. The proposed model was validated by the neutronic simulator developed in the PEN / COPPE / UFRJ for analysis of PWR reactors. (author)

  18. Gastric Cancer Cell Proliferation and Survival Is Enabled by a Cyclophilin B/STAT3/miR-520d-5p Signaling Feedback Loop.

    Science.gov (United States)

    Li, Ting; Guo, Hanqing; Zhao, Xiaodi; Jin, Jiang; Zhang, Lifeng; Li, Hong; Lu, Yuanyuan; Nie, Yongzhan; Wu, Kaichun; Shi, Yongquan; Fan, Daiming

    2017-03-01

    Molecular links between inflammation and cancer remain obscure despite their great pathogenic significance. The JAK2/STAT3 pathway activated by IL6 and other proinflammatory cytokines has garnered attention as a pivotal link in cancer pathogenesis, but the basis for its activation in cancer cells is not understood. Here we report that an IL6-triggered feedback loop involving STAT3-mediated suppression of miR-520d-5p and upregulation of its downstream target cyclophilin B (CypB) regulate the growth and survival of gastric cancer cells. In clinical specimens of gastric cancer, we documented increased expression of CypB and activation of STAT3. Mechanistic investigations identified miR-520d-5p as a regulator of CypB mRNA levels. This signaling axis regulated gastric cancer growth by modulating phosphorylation of STAT3. Furthermore, miR-520d-5p was identified as a direct STAT3 target and IL6-mediated inhibition of miR-520d-5p relied upon STAT3 activity. Our findings define a positive feedback loop that drives gastric carcinogenesis as influenced by H. pylori infections that involve proinflammatory IL6 stimulation. Cancer Res; 77(5); 1227-40. ©2016 AACR . ©2016 American Association for Cancer Research.

  19. Application of a Virtual Reactivity Feedback Control Loop in Non-Nuclear Testing of a Fast Spectrum Reactor

    International Nuclear Information System (INIS)

    Bragg-Sitton, Shannon M.; Forsbacka, Matthew

    2004-01-01

    For a compact, fast-spectrum reactor, reactivity feedback is dominated by core deformation at elevated temperature. Given the use of accurate deformation measurement techniques, it is possible to simulate nuclear feedback in non-nuclear electrically heated reactor tests. Implementation of simulated reactivity feedback in response to measured deflection is being tested at the Nasa Marshall Space Flight Center Early Flight Fission Test Facility (EFF-TF). During tests of the SAFE-100 reactor prototype, core deflection was monitored using a high resolution camera. 'Virtual' reactivity feedback was accomplished by applying the results of Monte Carlo calculations (MCNPX) to core deflection measurements; the computational analysis was used to establish the reactivity worth of various core deformations. The power delivered to the SAFE-100 prototype was then adjusted accordingly via kinetics calculations. The work presented in this paper will demonstrate virtual reactivity feedback as core power was increased from 1 kWt to 10 kWt, held approximately constant at 10 kWt, and then allowed to decrease based on the negative thermal reactivity coefficient. (authors)

  20. Effects of thermal-hydraulic feedback on burnup modeling of the deep burn modular high temperature reactor (DB-MHR)

    International Nuclear Information System (INIS)

    Bei, Yea; Wen, Wua; Di, Yuna; Stubbins, J.F.; Venneri, F.

    2007-01-01

    The Deep-Burn concept investigates the use of commercial high temperature gas-cooled reactors such as modular helium reactors (DB-MHR) to transmute spent fuel from light water reactors (LWRs). An essential feature of this technology is the fabrication of spent fuel into TRISO particles with full transuranic composition to achieve very extensive destruction levels (deep-burn) in a one-pass fuel cycle. Due to the strong temperature influence on the cross sections of transuranics, the coupling between temperature and neutronics is very important to be able to simulate realistic operations of the deep burn reactor. In this study, detailed simulations of the DB-MHR operation are performed with a Monte Carlo code system (MCNP-5 + ORIGEN-2.2 + MONTEBURNS-2 for neutronics calculations), POKE code (General Atomics, for thermohydraulics calculations) and NJOY-99 code (for processing nuclear data libraries), called MHRBURNS. Resulting power densities of fuel blocks (from neutronics calculations) are provided as input to the POKE code, which in turn, calculates new temperature distributions. The temperature distributions obtained from POKE are used to update the MCNP input, and NJOY is called to process new nuclear cross sections based on appropriate temperatures. These steps are repeated to calculate the entire burnup performance of the system. In this preliminary study only the feedback on graphite temperature is taken into account. It is observed that the temperature feedback results show a 200 K higher temperature and thus a slight difference in 237 Np and 239 Pu destruction rates, although the overall burnup rates remain the same

  1. The development of a thermal hydraulic feedback mechanism with a quasi-fixed point iteration scheme for control rod position modeling for the TRIGSIMS-TH application

    Science.gov (United States)

    Karriem, Veronica V.

    Nuclear reactor design incorporates the study and application of nuclear physics, nuclear thermal hydraulic and nuclear safety. Theoretical models and numerical methods implemented in computer programs are utilized to analyze and design nuclear reactors. The focus of this PhD study's is the development of an advanced high-fidelity multi-physics code system to perform reactor core analysis for design and safety evaluations of research TRIGA-type reactors. The fuel management and design code system TRIGSIMS was further developed to fulfill the function of a reactor design and analysis code system for the Pennsylvania State Breazeale Reactor (PSBR). TRIGSIMS, which is currently in use at the PSBR, is a fuel management tool, which incorporates the depletion code ORIGEN-S (part of SCALE system) and the Monte Carlo neutronics solver MCNP. The diffusion theory code ADMARC-H is used within TRIGSIMS to accelerate the MCNP calculations. It manages the data and fuel isotopic content and stores it for future burnup calculations. The contribution of this work is the development of an improved version of TRIGSIMS, named TRIGSIMS-TH. TRIGSIMS-TH incorporates a thermal hydraulic module based on the advanced sub-channel code COBRA-TF (CTF). CTF provides the temperature feedback needed in the multi-physics calculations as well as the thermal hydraulics modeling capability of the reactor core. The temperature feedback model is using the CTF-provided local moderator and fuel temperatures for the cross-section modeling for ADMARC-H and MCNP calculations. To perform efficient critical control rod calculations, a methodology for applying a control rod position was implemented in TRIGSIMS-TH, making this code system a modeling and design tool for future core loadings. The new TRIGSIMS-TH is a computer program that interlinks various other functional reactor analysis tools. It consists of the MCNP5, ADMARC-H, ORIGEN-S, and CTF. CTF was coupled with both MCNP and ADMARC-H to provide the

  2. Closing the feedback loop: engaging students in large first-year mathematics test revision sessions using pen-enabled screens

    Science.gov (United States)

    Donovan, Diane; Loch, Birgit

    2013-01-01

    How can active learning, peer learning and prompt feedback be achieved in large first-year mathematics classes? Further, what technologies may support these aims? In this article, we assert that test revision sessions in first-year mathematics held in a technology-enhanced lecture theatre can be highly interactive with students solving problems, learning from each other and receiving immediate feedback. This is facilitated by pen-enabled screens and synchronization software. We argue that the educational benefits achievable through the technology do outweigh the technological distractions, and that these benefits can be achieved by focused, targeted one-off sessions and not only by a semester-long, regular approach. Repeat mid-semester test revision sessions were offered on a non-compulsory basis using pen-enabled screens for all students. Students worked practice test questions and marked solutions to mathematical problems on the screens. Students' work was then displayed anonymously for their peers to see. Answers were discussed with the whole class. We discuss outcomes from two offerings of these sessions using student feedback and lecturer reflections and show the impact of participation on self-reported student confidence. Pedagogical approaches that the technology allowed for the first time in a large class are highlighted. Students responded uniformly positively.

  3. Generation of “gigantic” ultra-short microwave pulses based on passive mode-locking effect in electron oscillators with saturable absorber in the feedback loop

    International Nuclear Information System (INIS)

    Ginzburg, N. S.; Denisov, G. G.; Vilkov, M. N.; Zotova, I. V.; Sergeev, A. S.

    2016-01-01

    A periodic train of powerful ultrashort microwave pulses can be generated in electron oscillators with a non-linear saturable absorber installed in the feedback loop. This method of pulse formation resembles the passive mode-locking widely used in laser physics. Nevertheless, there is a specific feature in the mechanism of pulse amplification when consecutive energy extraction from different fractions of a stationary electron beam takes place due to pulse slippage over the beam caused by the difference between the wave group velocity and the electron axial velocity. As a result, the peak power of generated “gigantic” pulses can exceed not only the level of steady-state generation but also, in the optimal case, the power of the driving electron beam.

  4. Derivation of three closed loop kinematic velocity models using normalized quaternion feedback for an autonomous redundant manipulator with application to inverse kinematics

    International Nuclear Information System (INIS)

    Unseren, M.A.

    1993-04-01

    The report discusses the orientation tracking control problem for a kinematically redundant, autonomous manipulator moving in a three dimensional workspace. The orientation error is derived using the normalized quaternion error method of Ickes, the Luh, Walker, and Paul error method, and a method suggested here utilizing the Rodrigues parameters, all of which are expressed in terms of normalized quaternions. The analytical time derivatives of the orientation errors are determined. The latter, along with the translational velocity error, form a dosed loop kinematic velocity model of the manipulator using normalized quaternion and translational position feedback. An analysis of the singularities associated with expressing the models in a form suitable for solving the inverse kinematics problem is given. Two redundancy resolution algorithms originally developed using an open loop kinematic velocity model of the manipulator are extended to properly take into account the orientation tracking control problem. This report furnishes the necessary mathematical framework required prior to experimental implementation of the orientation tracking control schemes on the seven axis CESARm research manipulator or on the seven-axis Robotics Research K1207i dexterous manipulator, the latter of which is to be delivered to the Oak Ridge National Laboratory in 1993

  5. Derivation of three closed loop kinematic velocity models using normalized quaternion feedback for an autonomous redundant manipulator with application to inverse kinematics

    Energy Technology Data Exchange (ETDEWEB)

    Unseren, M.A.

    1993-04-01

    The report discusses the orientation tracking control problem for a kinematically redundant, autonomous manipulator moving in a three dimensional workspace. The orientation error is derived using the normalized quaternion error method of Ickes, the Luh, Walker, and Paul error method, and a method suggested here utilizing the Rodrigues parameters, all of which are expressed in terms of normalized quaternions. The analytical time derivatives of the orientation errors are determined. The latter, along with the translational velocity error, form a dosed loop kinematic velocity model of the manipulator using normalized quaternion and translational position feedback. An analysis of the singularities associated with expressing the models in a form suitable for solving the inverse kinematics problem is given. Two redundancy resolution algorithms originally developed using an open loop kinematic velocity model of the manipulator are extended to properly take into account the orientation tracking control problem. This report furnishes the necessary mathematical framework required prior to experimental implementation of the orientation tracking control schemes on the seven axis CESARm research manipulator or on the seven-axis Robotics Research K1207i dexterous manipulator, the latter of which is to be delivered to the Oak Ridge National Laboratory in 1993.

  6. Pilot-in-the-Loop Evaluation of a Yaw Rate to Throttle Feedback Control with Enhanced Engine Response

    Science.gov (United States)

    Litt, Jonathan S.; Guo, Ten-Huei; Sowers, T. Shane; Chicatelli, Amy K.; Fulton, Christopher E.; May, Ryan D.; Owen, A. Karl

    2012-01-01

    This paper describes the implementation and evaluation of a yaw rate to throttle feedback system designed to replace a damaged rudder. It can act as a Dutch roll damper and as a means to facilitate pilot input for crosswind landings. Enhanced propulsion control modes were implemented to increase responsiveness and thrust level of the engine, which impact flight dynamics and performance. Piloted evaluations were performed to determine the capability of the engines to substitute for the rudder function under emergency conditions. The results showed that this type of implementation is beneficial, but the engines' capability to replace the rudder is limited.

  7. Rubrocerebellar Feedback Loop Isolates the Interposed Nucleus as an Independent Processor of Corollary Discharge Information in Mice.

    Science.gov (United States)

    Beitzel, Christy S; Houck, Brenda D; Lewis, Samantha M; Person, Abigail L

    2017-10-18

    Understanding cerebellar contributions to motor coordination requires deeper insight into how the output structures of the cerebellum, the cerebellar nuclei, integrate their inputs and influence downstream motor pathways. The magnocellular red nucleus (RNm), a brainstem premotor structure, is a major target of the interposed nucleus (IN), and has also been described in previous studies to send feedback collaterals to the cerebellum. Because such a pathway is in a key position to provide motor efferent information to the cerebellum, satisfying predictions about the use of corollary discharge in cerebellar computations, we studied it in mice of both sexes. Using anterograde viral tracing, we show that innervation of cerebellum by rubrospinal neuron collaterals is remarkably selective for the IN compared with the cerebellar cortex. Optogenetic activation of the pathway in acute mouse brain slices drove IN activity despite small amplitude synaptic currents, suggesting an active role in IN information processing. Monosynaptic transsynaptic rabies tracing indicated the pathway contacts multiple cell types within the IN. By contrast, IN inputs to the RNm targeted a region that lacked inhibitory neurons. Optogenetic drive of IN inputs to the RNm revealed strong, direct excitation but no inhibition of RNm neurons. Together, these data indicate that the cerebellar nuclei are under afferent control independent of the cerebellar cortex, potentially diversifying its roles in motor control. SIGNIFICANCE STATEMENT The common assumption that all cerebellar mossy fibers uniformly collateralize to the cerebellar nuclei and cortex underlies classic models of convergent Purkinje influence on cerebellar output. Specifically, mossy fibers are thought to both directly excite nuclear neurons and drive polysynaptic feedforward inhibition via Purkinje neurons, setting up a fundamental computational unit. Here we present data that challenge this rule. A dedicated cerebellar nuclear afferent

  8. JMJD3 Is Crucial for the Female AVPV RIP-Cre Neuron-Controlled Kisspeptin-Estrogen Feedback Loop and Reproductive Function.

    Science.gov (United States)

    Song, Anying; Jiang, Shujun; Wang, Qinghua; Zou, Jianghuan; Lin, Zhaoyu; Gao, Xiang

    2017-06-01

    The hypothalamic-pituitary-gonadal axis controls development, reproduction, and metabolism. Although most studies have focused on the hierarchy from the brain to the gonad, many questions remain unresolved concerning the feedback from the gonad to the central nervous system, especially regarding the potential epigenetic modifications in hypothalamic neurons. In the present report, we generated genetically modified mice lacking histone H3 lysine 27 (H3K27) demethylase Jumonji domain-containing 3 (JMJD3) in hypothalamic rat-insulin-promoter-expressing neurons (RIP-Cre neurons). The female mutant mice displayed late-onset obesity owing to reduced locomotor activity and decreased energy expenditure. JMJD3 deficiency in RIP-Cre neurons also results in delayed pubertal onset, an irregular estrous cycle, impaired fertility, and accelerated ovarian failure in female mice owing to the dysregulation of the hypothalamic-ovarian axis. We found that JMJD3 directly regulates Kiss1 gene expression by binding to the Kiss1 promoter and triggering H3K27me3 demethylation in the anteroventral periventricular (AVPV) nucleus. Further study confirmed that the aberrations arose from impaired kisspeptin signaling in the hypothalamic AVPV nucleus and subsequent estrogen deficiency. Estrogen replacement therapy can reverse obesity in mutant mice. Moreover, we demonstrated that Jmjd3 is an estrogen target gene in the hypothalamus. These results provide direct genetic and molecular evidence that JMJD3 is a key mediator for the kisspeptin-estrogen feedback loop. Copyright © 2017 Endocrine Society.

  9. A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination.

    Science.gov (United States)

    Zhao, Chunnian; Sun, GuoQiang; Li, Shengxiu; Shi, Yanhong

    2009-04-01

    MicroRNAs have been implicated as having important roles in stem cell biology. MicroRNA-9 (miR-9) is expressed specifically in neurogenic areas of the brain and may be involved in neural stem cell self-renewal and differentiation. We showed previously that the nuclear receptor TLX is an essential regulator of neural stem cell self-renewal. Here we show that miR-9 suppresses TLX expression to negatively regulate neural stem cell proliferation and accelerate neural differentiation. Introducing a TLX expression vector that is not prone to miR-9 regulation rescued miR-9-induced proliferation deficiency and inhibited precocious differentiation. In utero electroporation of miR-9 in embryonic brains led to premature differentiation and outward migration of the transfected neural stem cells. Moreover, TLX represses expression of the miR-9 pri-miRNA. By forming a negative regulatory loop with TLX, miR-9 provides a model for controlling the balance between neural stem cell proliferation and differentiation.

  10. Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease.

    Science.gov (United States)

    Schonauer, Sophie; Körschen, Heinz G; Penno, Anke; Rennhack, Andreas; Breiden, Bernadette; Sandhoff, Konrad; Gutbrod, Katharina; Dörmann, Peter; Raju, Diana N; Haberkant, Per; Gerl, Mathias J; Brügger, Britta; Zigdon, Hila; Vardi, Ayelet; Futerman, Anthony H; Thiele, Christoph; Wachten, Dagmar

    2017-04-14

    The lysosomal acid β-glucosidase GBA1 and the non-lysosomal β-glucosidase GBA2 degrade glucosylceramide (GlcCer) to glucose and ceramide in different cellular compartments. Loss of GBA2 activity and the resulting accumulation of GlcCer results in male infertility, whereas mutations in the GBA1 gene and loss of GBA1 activity cause the lipid-storage disorder Gaucher disease. However, the role of GBA2 in Gaucher disease pathology and its relationship to GBA1 is not well understood. Here, we report a GBA1-dependent down-regulation of GBA2 activity in patients with Gaucher disease. Using an experimental approach combining cell biology, biochemistry, and mass spectrometry, we show that sphingosine, the cytotoxic metabolite accumulating in Gaucher cells through the action of GBA2, directly binds to GBA2 and inhibits its activity. We propose a negative feedback loop, in which sphingosine inhibits GBA2 activity in Gaucher cells, preventing further sphingosine accumulation and, thereby, cytotoxicity. Our findings add a new chapter to the understanding of the complex molecular mechanism underlying Gaucher disease and the regulation of β-glucosidase activity in general. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  11. SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.

    Directory of Open Access Journals (Sweden)

    Glenn M Marshall

    2011-06-01

    Full Text Available The N-Myc oncoprotein is a critical factor in neuroblastoma tumorigenesis which requires additional mechanisms converting a low-level to a high-level N-Myc expression. N-Myc protein is stabilized when phosphorylated at Serine 62 by phosphorylated ERK protein. Here we describe a novel positive feedback loop whereby N-Myc directly induced the transcription of the class III histone deacetylase SIRT1, which in turn increased N-Myc protein stability. SIRT1 binds to Myc Box I domain of N-Myc protein to form a novel transcriptional repressor complex at gene promoter of mitogen-activated protein kinase phosphatase 3 (MKP3, leading to transcriptional repression of MKP3, ERK protein phosphorylation, N-Myc protein phosphorylation at Serine 62, and N-Myc protein stabilization. Importantly, SIRT1 was up-regulated, MKP3 down-regulated, in pre-cancerous cells, and preventative treatment with the SIRT1 inhibitor Cambinol reduced tumorigenesis in TH-MYCN transgenic mice. Our data demonstrate the important roles of SIRT1 in N-Myc oncogenesis and SIRT1 inhibitors in the prevention and therapy of N-Myc-induced neuroblastoma.

  12. Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1.

    Science.gov (United States)

    Chang, Woochul; Lee, Chang Youn; Park, Jun-Hee; Park, Moon-Seo; Maeng, Lee-So; Yoon, Chee Soon; Lee, Min Young; Hwang, Ki-Chul; Chung, Yong-An

    2013-01-01

    The use of mesenchymal stem cells (MSCs) has emerged as a potential new treatment for myocardial infarction. However, the poor viability of MSCs after transplantation critically limits the efficacy of this new strategy. The expression of microRNA-210 (miR-210) is induced by hypoxia and is important for cell survival under hypoxic conditions. Hypoxia increases the levels of hypoxia inducible factor-1 (HIF-1) protein and miR-210 in human MSCs (hMSCs). miR-210 positively regulates HIF-1α activity. Furthermore, miR-210 expression is also induced by hypoxia through the regulation of HIF-1α. To investigate the effect of miR-210 on hMSC survival under hypoxic conditions, survival rates along with signaling related to cell survival were evaluated in hMSCs over-expressing miR-210 or ones that lacked HIF-1α expression. Elevated miR-210 expression increased survival rates along with Akt and ERK activity in hMSCs with hypoxia. These data demonstrated that a positive feedback loop involving miR-210 and HIF-1α was important for MSC survival under hypoxic conditions.

  13. Diabetes-Induced Oxidative Stress in Endothelial Progenitor Cells May Be Sustained by a Positive Feedback Loop Involving High Mobility Group Box-1

    Directory of Open Access Journals (Sweden)

    Han Wu

    2016-01-01

    Full Text Available Oxidative stress is considered to be a critical factor in diabetes-induced endothelial progenitor cell (EPC dysfunction, although the underlying mechanisms are not fully understood. In this study, we investigated the role of high mobility group box-1 (HMGB-1 in diabetes-induced oxidative stress. HMGB-1 was upregulated in both serum and bone marrow-derived monocytes from diabetic mice compared with control mice. In vitro, advanced glycation end productions (AGEs induced, expression of HMGB-1 in EPCs and in cell culture supernatants in a dose-dependent manner. However, inhibition of oxidative stress with N-acetylcysteine (NAC partially inhibited the induction of HMGB-1 induced by AGEs. Furthermore, p66shc expression in EPCs induced by AGEs was abrogated by incubation with glycyrrhizin (Gly, while increased superoxide dismutase (SOD activity in cell culture supernatants was observed in the Gly treated group. Thus, HMGB-1 may play an important role in diabetes-induced oxidative stress in EPCs via a positive feedback loop involving the AGE/reactive oxygen species/HMGB-1 pathway.

  14. Closed-Loop Feedback Computation Model of Dynamical Reputation Based on the Local Trust Evaluation in Business-to-Consumer E-Commerce

    Directory of Open Access Journals (Sweden)

    Bo Tian

    2016-02-01

    Full Text Available Trust and reputation are important factors that influence the success of both traditional transactions in physical social networks and modern e-commerce in virtual Internet environments. It is difficult to define the concept of trust and quantify it because trust has both subjective and objective characteristics at the same time. A well-reported issue with reputation management system in business-to-consumer (BtoC e-commerce is the “all good reputation” problem. In order to deal with the confusion, a new computational model of reputation is proposed in this paper. The ratings of each customer are set as basic trust score events. In addition, the time series of massive ratings are aggregated to formulate the sellers’ local temporal trust scores by Beta distribution. A logical model of trust and reputation is established based on the analysis of the dynamical relationship between trust and reputation. As for single goods with repeat transactions, an iterative mathematical model of trust and reputation is established with a closed-loop feedback mechanism. Numerical experiments on repeated transactions recorded over a period of 24 months are performed. The experimental results show that the proposed method plays guiding roles for both theoretical research into trust and reputation and the practical design of reputation systems in BtoC e-commerce.

  15. Thermal hydraulic considerations and mock-up tests for developing two-phase thermo-siphon loop of CARR-CNS

    International Nuclear Information System (INIS)

    Shejiao, Du; Qincheng, Bi; Tingkuan, Chen; Quanke, Feng

    2005-01-01

    The main component of the China Advanced Research Reactor Cold Neutron Source (CARR-CNS), which is under design, is a two-phase thermo-siphon loop of hydrogen. It consists of a condenser, a single tube with counter current flow avoiding flooding and a cylindrical-annulus moderator cell. The mockup tests were carried out using a full-scale loop with Freon-113, to validate the self-regulating characteristics of the loop, void fraction less than 20% in the liquid of the moderator cell and the requirements for establishing the condition under which the inner shell of the moderator cell has only vapor and the outer shell liquid. In the case of these mockup tests the density ratio of liquid to vapor and the volumetric vapor evaporation rate due to heat load are kept the same as those in normal operation of the CARR-CNS. The results show that the loop has the self-regulating characteristics and the inner shell of the moderator cell contains only vapor, the outer shell liquid. The average void fraction of the moderator cell was verified less than 20% under the volumetric vapor generation of 0.65 l/s corresponding to the nuclear heating of 800 W in the case of the liquid hydrogen. The local void fraction in the liquid hydrogen increases with the increase of the loop pressure under the condition of a constant volumetric evaporation

  16. CDK4 and miR-15a comprise an abnormal automodulatory feedback loop stimulating the pathogenesis and inducing chemotherapy resistance in nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Liu, Zhen; Cheng, Chao; Luo, Xiaojun; Xia, Qiong; Zhang, Yejie; Long, Xiaobing; Jiang, Qingping; Fang, Weiyi

    2016-01-01

    In previous investigation, we reported that stably knocking down cyclin-dependent kinase 4(CDK4) induced expression of let-7c, which further suppressed cell cycle transition and cell growth by modulating cell cycle signaling in nasopharyngeal carcinoma (NPC). In this study, we further explored the molecular function and mechanism of CDK4 modulating miRNAs to stimulate cell cycle transition, cell growth, and Cisplatin (DDP) -resistance on in NPC. We identified changes in miRNAs by miRNA array and real-time PCR and the effect on DDP after knocking down CDK4 in NPC cells. Further, we investigated the molecular mechanisms by which CDK4 modulated miR-15a in NPC. Moreover, we also explored the role of miR-15a and the effect on DDP in NPC. Finally, we analyzed the correlation of miR-15a and CDK4 expression in NPC tissues. In addition to let-7 family members, we observed that upregulated expression of miR-15a was significantly induced in CDK4-suppressed NPC cells. Further, we found that knocking down CDK4 suppressed c-Myc expression, and the latter directly suppressed the expression of miR-15a in NPC. Furthermore, miR-15a as a tumor suppressor antagonized CDK4 repressing cell cycle progression and cell growth in vitro and in vivo and induced the sensitivity of cells to DDP by regulating the c-Myc/CCND1/CDK4/E2F1 pathway in NPC. Finally, miR-15a was negatively weak correlated with the expression of CDK4 in NPC. Our studies demonstrate that CDK4 and miR-15a comprise an abnormal automodulatory feedback loop stimulating the pathogenesis and inducing chemotherapy resistance in NPC. The online version of this article (doi:10.1186/s12885-016-2277-2) contains supplementary material, which is available to authorized users

  17. How short RNAs impact the human ribonuclease Dicer activity: putative regulatory feedback-loops and other RNA-mediated mechanisms controlling microRNA processing.

    Science.gov (United States)

    Koralewska, Natalia; Hoffmann, Weronika; Pokornowska, Maria; Milewski, Marek; Lipinska, Andrea; Bienkowska-Szewczyk, Krystyna; Figlerowicz, Marek; Kurzynska-Kokorniak, Anna

    2016-01-01

    Ribonuclease Dicer plays a pivotal role in RNA interference pathways by processing long double-stranded RNAs and single-stranded hairpin RNA precursors into small interfering RNAs (siRNAs) and microRNAs (miRNAs), respectively. While details of Dicer regulation by a variety of proteins are being elucidated, less is known about non-protein factors, e.g. RNA molecules, that may influence this enzyme's activity. Therefore, we decided to investigate the question of whether the RNA molecules can function not only as Dicer substrates but also as its regulators. Our previous in vitro studies indicated that the activity of human Dicer can be influenced by short RNA molecules that either bind to Dicer or interact with its substrates, or both. Those studies were carried out with commercial Dicer preparations. Nevertheless, such preparations are usually not homogeneous enough to carry out more detailed RNA-binding studies. Therefore, we have established our own system for the production of human Dicer in insect cells. In this manuscript, we characterize the RNA-binding and RNA-cleavage properties of the obtained preparation. We demonstrate that Dicer can efficiently bind single-stranded RNAs that are longer than ~20-nucleotides. Consequently, we revisit possible scenarios of Dicer regulation by single-stranded RNA species ranging from ~10- to ~60-nucleotides, in the context of their binding to this enzyme. Finally, we show that siRNA/miRNA-sized RNAs may affect miRNA production either by binding to Dicer or by participating in regulatory feedback-loops. Altogether, our studies suggest a broad regulatory role of short RNAs in Dicer functioning.

  18. M2 macrophages induce ovarian cancer cell proliferation via a heparin binding epidermal growth factor/matrix metalloproteinase 9 intercellular feedback loop.

    Science.gov (United States)

    Carroll, Molly J; Kapur, Arvinder; Felder, Mildred; Patankar, Manish S; Kreeger, Pamela K

    2016-12-27

    In ovarian cancer, a high ratio of anti-inflammatory M2 to pro-inflammatory M1 macrophages correlates with poor patient prognosis. The mechanisms driving poor tumor outcome as a result of the presence of M2 macrophages in the tumor microenvironment remain unclear and are challenging to study with current techniques. Therefore, in this study we utilized a micro-culture device previously developed by our lab to model concentrated paracrine signaling in order to address our hypothesis that interactions between M2 macrophages and ovarian cancer cells induce tumor cell proliferation. Using the micro-culture device, we determined that co-culture with M2-differentiated primary macrophages or THP-1 increased OVCA433 proliferation by 10-12%. This effect was eliminated with epidermal growth factor receptor (EGFR) or heparin-bound epidermal growth factor (HB-EGF) neutralizing antibodies and HBEGF expression in peripheral blood mononuclear cells from ovarian cancer patients was 9-fold higher than healthy individuals, suggesting a role for HB-EGF in tumor progression. However, addition of HB-EGF at levels secreted by macrophages or macrophage-conditioned media did not induce proliferation to the same extent, indicating a role for other factors in this process. Matrix metalloproteinase-9, MMP-9, which cleaves membrane-bound HB-EGF, was elevated in co-culture and its inhibition decreased proliferation. Utilizing inhibitors and siRNA against MMP9 in each population, we determined that macrophage-secreted MMP-9 released HB-EGF from macrophages, which increased MMP9 in OVCA433, resulting in a positive feedback loop to drive HB-EGF release and increase proliferation in co-culture. Identification of multi-cellular interactions such as this may provide insight into how to most effectively control ovarian cancer progression.

  19. Downregulation of IL6 Targeted MiR-376b May Contribute to a Positive IL6 Feedback Loop During Early Liver Regeneration in Mice

    Directory of Open Access Journals (Sweden)

    Shan Lu

    2015-08-01

    Full Text Available Background/Aims: MicroRNAs (miRNAs are a group of endogenous, small, noncoding RNAs implicated in a variety of biological processes, including cell proliferation, apoptosis, differentiation and metabolism. The present study aims to explore the potential role and molecular mechanism of miR-376b during the early phase of liver regeneration. Methods: MiRNA profiling microarrays were used to assess the changes in miRNA expression. For functional analysis, cell proliferation, apoptosis assays, real time quantitative PCR and westernblot analysis were performed. Results: The comprehensive miRNA expression profiling assays on regenerating liver tissues 4 h after partial hepatectomy (PH showed that three miRNAs (miR-127, miR-376b and miR-494 located in the Dlk1-Gtl2 miRNA cluster were significantly downregulated. In vitro functional studies demonstrated that high-level interleukin 6 (IL6 inhibited the expression of miR-376b, and miR-376b mimics treatment decreased cell proliferation and increased apoptosis. Further target analysis showed that miR-376b reduced the mRNA and protein expression levels of NF-kappa-B inhibitor zeta (NFKBIZ and signal transducers and transcription activators 3 (STAT3. Additionally, IL6-induced miR-376b downregulation would, in turn, increase the expression of IL-6 possibly via a feedback loop involving NFKBIZ or/and STAT3. Conclusion: During the early phase of liver regeneration, miR-376b expression was significantly decreased. Our findings reveal that a regulatory circuitry between miR-376b and IL-6 may exist, which trigger the initiation of liver regeneration.

  20. Coupled calculation of the radiological release and the thermal-hydraulic behavior of a 3-loop PWR after a SGTR by means of the code RELAP5

    Energy Technology Data Exchange (ETDEWEB)

    Van Hove, W.; Van Laeken, K.; Bartsoen, L. [Belgatom, Brussels (Belgium)] [and others

    1995-09-01

    To enable a more realistic and accurate calculation of the radiological consequences of a SGTR, a fission product transport model was developed. As the radiological releases strongly depend on the thermal-hydraulic transient, the model was included in the RELAP5 input decks of the Belgian NPPs. This enables the coupled calculation of the thermal-hydraulic transient and the radiological release. The fission product transport model tracks the concentration of the fission products in the primary circuit, in each of the SGs as well as in the condenser. This leads to a system of 6 coupled, first order ordinary differential equations with time dependent coefficients. Flashing, scrubbing, atomisation and dry out of the break flow are accounted for. Coupling with the thermal-hydraulic calculation and correct modelling of the break position enables an accurate calculation of the mixture level above the break. Pre- and post-accident spiking in the primary circuit are introduced. The transport times in the FW-system and the SG blowdown system are also taken into account, as is the decontaminating effect of the primary make-up system and of the SG blowdown system. Physical input parameters such as the partition coefficients, half life times and spiking coefficients are explicitly introduced so that the same model can be used for iodine, caesium and noble gases.

  1. Fault Tolerant Feedback Control

    DEFF Research Database (Denmark)

    Stoustrup, Jakob; Niemann, H.

    2001-01-01

    An architecture for fault tolerant feedback controllers based on the Youla parameterization is suggested. It is shown that the Youla parameterization will give a residual vector directly in connection with the fault diagnosis part of the fault tolerant feedback controller. It turns out...... that there is a separation be-tween the feedback controller and the fault tolerant part. The closed loop feedback properties are handled by the nominal feedback controller and the fault tolerant part is handled by the design of the Youla parameter. The design of the fault tolerant part will not affect the design...... of the nominal feedback con-troller....

  2. Hydraulic analysis of looped waster network on peak flow conditions; Analisis hidraulico de redes malladas de abastecimiento en condiciones de maxima demanda

    Energy Technology Data Exchange (ETDEWEB)

    Martinez Solano, F. J.; Iglesias Rey, P. L.; Fuertes Miquel, V. S.; Lopez Jimenez, P. A.

    2007-07-01

    The models of a water supply network are classified in detailed models and strategic models depending on its characteristics. In the case of detailed model, the objective consists of studying the behaviour of the network when extreme situations occurs. Usually, billing data from customers are used to estimate the demands at the network nodes. This made that demand an average value of the flow. In other words, we are using true dat to obtain fictions situations. This is specially tru when the network is smaller. In this article, a methodology to load allocation in detailed models is presented. This load allocation will be valid for both branched and looped networks. (Author) 10 refs.

  3. Model-based open-loop control design for a hydraulic brake system with switching solenoid valves; Modellbasierter Steuerungsentwurf fuer ein hydraulisches Bremssystem mit magnetischen Schaltventilen

    Energy Technology Data Exchange (ETDEWEB)

    Lolenko, K.; Fehn, A.A.R. [Robert Bosch GmbH, Abstatt (Germany). CC/ESM

    2007-02-15

    This paper presents a novel concept for the model-based open-loop control design of switching solenoid valves. The control is suitable for the wheel brake calliper pressure setting during vehicle dynamics control, as e. g. by ESP or ABS [1;11]. For the control design the reduced model, taking into account all essential nonlinearities of the system as well as environmental effects (e.g. temperature), was derived from the detailed simulation model. The transition times and other characteristic time intervals describing the dynamic behaviour of the solenoid valve are calculated from the equations of the reduced model through symbolic integration or approximative by means of taylor series. The calculated time intervals serve to define the control impulse duration of the valve from the desired calliper pressure. In simulation studies the designed control has been proven to be an efficient approach and allows improved pressure control accuracy for conventional brake systems. (orig.)

  4. HYDRAULIC SERVO CONTROL MECHANISM

    Science.gov (United States)

    Hussey, R.B.; Gottsche, M.J. Jr.

    1963-09-17

    A hydraulic servo control mechanism of compact construction and low fluid requirements is described. The mechanism consists of a main hydraulic piston, comprising the drive output, which is connected mechanically for feedback purposes to a servo control piston. A control sleeve having control slots for the system encloses the servo piston, which acts to cover or uncover the slots as a means of controlling the operation of the system. This operation permits only a small amount of fluid to regulate the operation of the mechanism, which, as a result, is compact and relatively light. This mechanism is particuiarly adaptable to the drive and control of control rods in nuclear reactors. (auth)

  5. Loop kinematics

    International Nuclear Information System (INIS)

    Migdal, A.A.

    1982-01-01

    Basic operators acting in the loop space are introduced. The topology of this space and properties of the Stokes type loop functionals are discussed. The parametrically invariant loop calculus developed here is used in the loop dynamics

  6. Hybrid Robust Control Law with Disturbance Observer for High-Frequency Response Electro-Hydraulic Servo Loading System

    Directory of Open Access Journals (Sweden)

    Zhiqing Sheng

    2016-04-01

    Full Text Available Addressing the simulating issue of the helicopter-manipulating booster aerodynamic load with high-frequency dynamic load superimposed on a large static load, this paper studies the design of the robust controller for the electro-hydraulic loading system to realize the simulation of this kind of load. Firstly, the equivalent linear model of the electro-hydraulic loading system under assumed parameter uncertainty is established. Then, a hybrid control scheme is proposed for the loading system. This control scheme consists of a constant velocity feed-forward compensator, a robust inner loop compensator based on disturbance observer and a robust outer loop feedback controller. The constant velocity compensator eliminates most of the extraneous force at first, and then the double-loop cascade composition control strategy is employed to design the compensated system. The disturbance observer–based inner loop compensator further restrains the disturbances including the remaining extraneous force, and makes the actual plant tracking a nominal model approximately in a certain frequency range. The robust outer loop controller achieves the desired force-tracking performance, and guarantees system robustness in the high frequency region. The optimized low-pass filter Q(s is designed by using the H∞ mixed sensitivity optimization method. The simulation results show that the proposed hybrid control scheme and controller can effectively suppress the extraneous force and improve the robustness of the electro-hydraulic loading system.

  7. Controls of Hydraulic Wind Turbine

    Directory of Open Access Journals (Sweden)

    Zhang Yin

    2016-01-01

    Full Text Available In this paper a hydraulic wind turbine generator system was proposed based on analysis the current wind turbines technologies. The construction and principles were introduced. The mathematical model was verified using MATLAB and AMsim. A displacement closed loop of swash plate of motor and a speed closed loop of generator were setup, a PID control is introduced to maintain a constant speed and fixed frequency at wind turbine generator. Simulation and experiment demonstrated that the system can connect grid to generate electric and enhance reliability. The control system demonstrates a high performance speed regulation and effectiveness. The results are great significant to design a new type hydraulic wind turbine system.

  8. Self-starting and overclocking a harmonically mode-locking WRC-FPLD with a dual-loop feedback controller for 10 Gb s−1 pulse-data transmission

    International Nuclear Information System (INIS)

    Lin, Chun-Ju; Chi, Yu-Chieh; Lin, Gong-Ru

    2013-01-01

    The self-starting and overclocking of a harmonically mode-locked weak-resonant-cavity Fabry–Perot laser diode (WRC-FPLD) with a dual-loop coupled optoelectronic oscillator (COEO) based feedback controller is demonstrated to perform a clock-free pulsed data transmission at 10 Gb s −1 . The WRC-FPLD is considered as the preferred candidate for harmonic mode-locking due to its highly asymmetric cavity architecture, whereby the spontaneous noise can be significantly suppressed without inducing large intra-cavity loss. With the dual-loop COEO configuration, the WRC-FPLD can be boosted to four times of its original modulation bandwidth such that the pulsed carrier quality can be refined. The structure-optimizing principle with the closed-loop model is corroborated by the effective spurious-noise-suppression. The lowest phase noises as low as −100 dBc Hz −1 at 10 kHz with corresponding RMS timing jitter of 0.67 ps are measured. This is achieved by individually inserting 100 and 120 m long single mode fiber segments into two decoupled arms, the dual-loop COEO before the optical receiver pair. The BER performance reaches a minimum with the optimized SMF segment lengths. However, the spurious peaks arise to degrade the BER performance as the phase noise and jitter are inevitably enlarged when inserting longer SMF segments. After modulating the optimized output pulse train with the pseudo-random-bit-sequence data triggered by the same COEO clock, the SNR can achieve 10.9 dB and the receiving sensitivity is −19.2 dBm. (letter)

  9. CONTROL OF LASER RADIATION PARAMETERS: Influence of feedback loop characteristics on the field structure in a phase-conjugating ring mirror

    Science.gov (United States)

    Esayan, A. A.; Zozulya, A. A.; Tikhonchuk, Vladimir T.

    1991-10-01

    An analysis is made of stimulated scattering in a ring resonator formed by a self-intersecting beam with simultaneous rotation and contraction of the beam due to feedback. Conditions for the excitation of lasing are obtained and the phase conjugation quality is determined near the lasing threshold.

  10. A chopper current-feedback instrumentation amplifier with a 1 mHz 1/f noise corner and an AC-coupled ripple reduction loop

    NARCIS (Netherlands)

    Wu, R.; Makinwa, K.A.A.; Huijsing, J.H.

    2009-01-01

    This paper presents a chopper instrumentation amplifier for interfacing precision thermistor bridges. For high CMRR and DC gain, the amplifier employs a three-stage current-feedback topology with nested-Miller compensation. By chopping both the input and intermediate stages of the amplifier, a 1 mHz

  11. Hydraulic structures

    CERN Document Server

    Chen, Sheng-Hong

    2015-01-01

    This book discusses in detail the planning, design, construction and management of hydraulic structures, covering dams, spillways, tunnels, cut slopes, sluices, water intake and measuring works, ship locks and lifts, as well as fish ways. Particular attention is paid to considerations concerning the environment, hydrology, geology and materials etc. in the planning and design of hydraulic projects. It also considers the type selection, profile configuration, stress/stability calibration and engineering countermeasures, flood releasing arrangements and scouring protection, operation and maintenance etc. for a variety of specific hydraulic structures. The book is primarily intended for engineers, undergraduate and graduate students in the field of civil and hydraulic engineering who are faced with the challenges of extending our understanding of hydraulic structures ranging from traditional to groundbreaking, as well as designing, constructing and managing safe, durable hydraulic structures that are economical ...

  12. Small scale thermal-hydraulic experiment for stable operation of a pius-type reactor

    International Nuclear Information System (INIS)

    Tasaka, K.; Tamaki, M.; Imai, S.; Irianto, I.D.; Tsuji, Y.; Kukita, Y.

    1994-01-01

    Thermal-hydraulic experiments using a small-scale atmospheric pressure test loop have been performed for the Process Inherent Ultimate Safety (PIUS)-type reactor to develop the new pump speed feedback control system. Three feedback control systems based on the measurement of flow rate, differential pressure, and fluid temperature distribution in the lower density lock have been proposed and confirmed by a series of experiments. Each of the feedback control systems had been verified in the simulation experiment such as a start-up simulation test. The automatic pump speed control based on the fluid temperature at the lower density lock was quite effective to maintain the stratified interface between primary water and borated pool water for stable operation of the reactor. (author)

  13. Cytokine loops driving senescence

    Czech Academy of Sciences Publication Activity Database

    Bartek, Jiří; Hodný, Zdeněk; Lukáš, Jan

    2008-01-01

    Roč. 10, č. 8 (2008), s. 887-889 ISSN 1465-7392 Institutional research plan: CEZ:AV0Z50520514 Keywords : cellular senescence * cytokines * autocrine feedback loop Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 17.774, year: 2008

  14. Hydraulic turbines

    International Nuclear Information System (INIS)

    Meluk O, G.

    1998-01-01

    The hydraulic turbines are defined according to the specific speed, in impulse turbines and in reaction turbines. Currently, the Pelton turbines (of impulse) and the Francis and Kaplan turbines (of reaction), they are the most important machines in the hydroelectric generation. The hydraulic turbines are capable of generating in short times, large powers, from its loads zero until the total load and reject the load instantly without producing damages in the operation. When the hydraulic resources are important, the hydraulic turbines are converted in the axle of the electric system. Its combination with thermoelectric generation systems, it allow the continuing supply of the variations in demand of energy system. The available hydraulic resource in Colombia is of 93085 MW, of which solely 9% is exploited, become 79% of all the electrical country generation, 21% remaining is provided by means of the thermoelectric generation

  15. Interrogation of inhibitor of nuclear factor κB α/nuclear factor κB (IκBα/NF-κB) negative feedback loop dynamics: from single cells to live animals in vivo.

    Science.gov (United States)

    Moss, Britney L; Elhammali, Adnan; Fowlkes, Tiffanie; Gross, Shimon; Vinjamoori, Anant; Contag, Christopher H; Piwnica-Worms, David

    2012-09-07

    Full understanding of the biological significance of negative feedback processes requires interrogation at multiple scales as follows: in single cells, cell populations, and live animals in vivo. The transcriptionally coupled IκBα/NF-κB negative feedback loop, a pivotal regulatory node of innate immunity and inflammation, represents a model system for multiscalar reporters. Using a κB(5)→IκBα-FLuc bioluminescent reporter, we rigorously evaluated the dynamics of ΙκBα degradation and subsequent NF-κB transcriptional activity in response to diverse modes of TNFα stimulation. Modulating TNFα concentration or pulse duration yielded complex, reproducible, and differential ΙκBα dynamics in both cell populations and live single cells. Tremendous heterogeneity in the transcriptional amplitudes of individual responding cells was observed, which was greater than the heterogeneity in the transcriptional kinetics of responsive cells. Furthermore, administration of various TNFα doses in vivo generated ΙκBα dynamic profiles in the liver resembling those observed in single cells and populations of cells stimulated with TNFα pulses. This suggested that dose modulation of circulating TNFα was perceived by hepatocytes in vivo as pulses of increasing duration. Thus, a robust bioluminescent reporter strategy enabled rigorous quantitation of NF-κB/ΙκBα dynamics in both live single cells and cell populations and furthermore, revealed reproducible behaviors that informed interpretation of in vivo studies.

  16. Basic hydraulics

    CERN Document Server

    Smith, P D

    1982-01-01

    BASIC Hydraulics aims to help students both to become proficient in the BASIC programming language by actually using the language in an important field of engineering and to use computing as a means of mastering the subject of hydraulics. The book begins with a summary of the technique of computing in BASIC together with comments and listing of the main commands and statements. Subsequent chapters introduce the fundamental concepts and appropriate governing equations. Topics covered include principles of fluid mechanics; flow in pipes, pipe networks and open channels; hydraulic machinery;

  17. Regenerative feedback resonant circuit

    Science.gov (United States)

    Jones, A. Mark; Kelly, James F.; McCloy, John S.; McMakin, Douglas L.

    2014-09-02

    A regenerative feedback resonant circuit for measuring a transient response in a loop is disclosed. The circuit includes an amplifier for generating a signal in the loop. The circuit further includes a resonator having a resonant cavity and a material located within the cavity. The signal sent into the resonator produces a resonant frequency. A variation of the resonant frequency due to perturbations in electromagnetic properties of the material is measured.

  18. Control algorithm for the inverter fed induction motor drive with DC current feedback loop based on principles of the vector control

    Energy Technology Data Exchange (ETDEWEB)

    Vuckovic, V.; Vukosavic, S. (Electrical Engineering Inst. Nikola Tesla, Viktora Igoa 3, Belgrade, 11000 (Yugoslavia))

    1992-01-01

    This paper brings out a control algorithm for VSI fed induction motor drives based on the converter DC link current feedback. It is shown that the speed and flux can be controlled over the wide speed and load range quite satisfactorily for simpler drives. The base commands of both the inverter voltage and frequency are proportional to the reference speed, but each of them is further modified by the signals derived from the DC current sensor. The algorithm is based on the equations well known from the vector control theory, and is aimed to obtain the constant rotor flux and proportionality between the electrical torque, the slip frequency and the active component of the stator current. In this way, the problems of slip compensation, Ri compensation and correction of U/f characteristics are solved in the same time. Analytical considerations and computer simulations of the proposed control structure are in close agreement with the experimental results measured on a prototype drive.

  19. Hydraulic Structures

    Data.gov (United States)

    Department of Homeland Security — This table is required whenever hydraulic structures are shown in the flood profile. It is also required if levees are shown on the FIRM, channels containing the...

  20. Calculation and analysis of thermal–hydraulics fluctuations in pressurized water reactors

    International Nuclear Information System (INIS)

    Malmir, Hessam; Vosoughi, Naser

    2015-01-01

    Highlights: • Single-phase thermal–hydraulics noise equations are originally derived in the frequency domain. • The fluctuations of all the coolant parameters are calculated, without any simplifying assumptions. • The radial distribution of the temperature fluctuations in the fuel, gap and cladding are taken into account. • The closed-loop calculations are performed by means of the point kinetics noise theory. • Both the space- and frequency-dependence of the thermal–hydraulics fluctuations are analyzed. - Abstract: Analysis of thermal–hydraulics fluctuations in pressurized water reactors (e.g., local and global temperature or density fluctuations, as well as primary and charging pumps fluctuations) has various applications in calculation or measurement of the core dynamical parameters (temperature or density reactivity coefficients) in addition to thermal–hydraulics surveillance and diagnostics. In this paper, the thermal–hydraulics fluctuations in PWRs are investigated. At first, the single-phase thermal–hydraulics noise equations (in the frequency domain) are originally derived, without any simplifying assumptions. The fluctuations of all the coolant parameters, as well as the radial distribution of the temperature fluctuations in the fuel, gap and cladding are taken into account. Then, the derived governing equations are discretized using the finite volume method (FVM). Based on the discretized equations and the proposed algorithm of solving, a single heated channel noise calculation code (SHC-Noise) is developed, by which the steady-state and fluctuating parameters of PWR fuel assemblies can be calculated. The noise sources include the inlet coolant temperature and velocity fluctuations, in addition to the power density noises. The developed SHC-Noise code is benchmarked in different cases and scenarios. Furthermore, to show the effects of the power feedbacks, the closed-loop calculations are performed by means of the point kinetics noise

  1. Hydraulic nuts (hydranuts) for critical bolted joints

    International Nuclear Information System (INIS)

    Greenwell, S.

    2008-01-01

    HydraNuts replace the original nut and torquing equipment, combining the two functions into one system. Designed for simple installation and operation, HydraNuts are fitted to the stud bolts. Once all HydraNuts are fitted to the application, flexible hydraulic hoses are connected, forming a closed loop hydraulic harness, allowing simultaneous pressurization of all HydraNuts. Hydraulic pressure is obtained by the use of a pumping unit and the resultant load generated is transferred to the studs and flange closure is obtained. Locking rings are rotated into place, supporting the tensioned load mechanically after hydraulic pressure is released. The hose harness is removed. (author)

  2. A positive feedback loop between progesterone and microsomal prostaglandin E synthase-1-mediated PGE2 promotes production of both in mouse granulosa cells.

    Science.gov (United States)

    Tamura, Kazuhiro; Naraba, Hiroaki; Hara, Takahiko; Nakamura, Kota; Yoshie, Mikihiro; Kogo, Hiroshi; Tachikawa, Eiichi

    2016-03-01

    Microsomal prostaglandin E synthase-1 (mPGES-1) is primarily expressed in granulosa cells (GCs) in the preovulatory follicle. Both prostaglandin E2 (PGE2) and progesterone (P4) are implicated in various reproductive functions. Here, we demonstrate that mPges-1 may be a direct downstream target gene of the P4 receptor and P4-stimulated PGE2 secretion can stimulate P4 production in a newly generated mouse GC line (GtsT). Treatment of GtsT cells with a P4 receptor agonist, norgestrel, markedly increased mPGES-1 expression detected by RT-PCR analysis. PGE2 secretion measured by an enzyme-linked immunosorbent assay was enhanced by P4 treatment. Luciferase assays revealed that the proximal promoter region of the mPges-1 gene was responsible for the effects of P4 treatment. Conversely, PGE2 treatment stimulated P4 secretion, which coordinated with mRNA expression of steroidogenic acute regulatory protein. Taken together, P4 may regulate mPGES-1 expression to increase PGE2 secretion and in turn P4 production. An autocrine loop between P4 and PGE2 might function to maintain the increased levels of both in GCs. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Polarization chaos and random bit generation in nonlinear fiber optics induced by a time-delayed counter-propagating feedback loop.

    Science.gov (United States)

    Morosi, J; Berti, N; Akrout, A; Picozzi, A; Guasoni, M; Fatome, J

    2018-01-22

    In this manuscript, we experimentally and numerically investigate the chaotic dynamics of the state-of-polarization in a nonlinear optical fiber due to the cross-interaction between an incident signal and its intense backward replica generated at the fiber-end through an amplified reflective delayed loop. Thanks to the cross-polarization interaction between the two-delayed counter-propagating waves, the output polarization exhibits fast temporal chaotic dynamics, which enable a powerful scrambling process with moving speeds up to 600-krad/s. The performance of this all-optical scrambler was then evaluated on a 10-Gbit/s On/Off Keying telecom signal achieving an error-free transmission. We also describe how these temporal and chaotic polarization fluctuations can be exploited as an all-optical random number generator. To this aim, a billion-bit sequence was experimentally generated and successfully confronted to the dieharder benchmarking statistic tools. Our experimental analysis are supported by numerical simulations based on the resolution of counter-propagating coupled nonlinear propagation equations that confirm the observed behaviors.

  4. The PTHrP-Ihh feedback loop in the embryonic growth plate allows PTHrP to control hypertrophy and Ihh to regulate proliferation.

    Science.gov (United States)

    van Donkelaar, C C; Huiskes, R

    2007-01-01

    Growth plate and long bone development is governed by biochemical signaling pathways of which the PTHrP-Ihh system is the best known. Other factors, such as BMPs, FGFs and mechanical loading, may interact with this system. This study aims at elucidating the relative importance of PTHrP and Ihh for controlling proliferation, and hypertrophy in fetal growth plate cartilage. We assessed the question why reduced Ihh expression leads to more pronounced effects on the number of non-hypertrophic cells and total bone formation, compared to PTHrP down-regulation. Using few basic equations, constituted from literature data, this paper shows how the PTHrP-Ihh feedback system can control different aspects of tissue differentiation at distinct locations. In particular, it is shown that (mechanical or biochemical) perturbations will affect proliferation via Ihh-related parameters, whereas changes in PTHrP-related parameters selectively interact with hypertrophy. This is contra-intuitive, since PTHrP acts to keep cells proliferating. In this context, the critical PTHrP level for keeping cells proliferating has been reconsidered. In addition, an explanation is provided for the aforementioned difference in effect between reduced Ihh and PTHrP expression.

  5. X-37 separation from a B-52H: application of multi-body dynamics and closed-loop feedback using overset CFD

    International Nuclear Information System (INIS)

    Jolly, B.; Rizk, M.; Moran, R.

    2005-01-01

    The Air Force SEEK EAGLE Office (AFSEO) provided independent aerodynamic data, which was key in the separation analysis for the X-37 Approach and Landing Test Vehicle (ALTV). To ensure the best aerodynamic B-52H interference database would be generated for the analysis, NASA contracted both NASA Johnson Space Center (JSC) and the AFSEO via the 412th Flight Test Squadron (Edwards AFB CA) to run independent Computational Fluid Dynamics (CFD) studies. These data were then compared to the existing database from Boeing to establish confidence and determine areas of uncertainty. NASA requested CFD data from the AFSEO primarily for static and carriage solutions of the X-37 at various positions under the B-52H. In addition, several dynamic simulations of X-37 trajectories used rate feedback control to deflect the control surfaces to stabilize the X-37. The AFSEO CFD team calculated 140 static, unsteady solutions and 9 dynamic time-accurate trajectory simulations between April 2003 and June 2004 to support the NASA X-37 ALTV program. The computational models used structured adjacent and overlapping grids with the total computational domain consisting of 25 million points in 315 grids. The rate-control autopilot commanded both yaw and roll in four control surfaces; pitch commands were preset. The results show significant increase in stability of the X-37 trajectory from the B-52H. (author)

  6. Audio Feedback -- Better Feedback?

    Science.gov (United States)

    Voelkel, Susanne; Mello, Luciane V.

    2014-01-01

    National Student Survey (NSS) results show that many students are dissatisfied with the amount and quality of feedback they get for their work. This study reports on two case studies in which we tried to address these issues by introducing audio feedback to one undergraduate (UG) and one postgraduate (PG) class, respectively. In case study one…

  7. High speed hydraulic scanner for deep x-ray lithography

    International Nuclear Information System (INIS)

    Milne, J.C.; Johnson, E.D.

    1997-07-01

    From their research and development in hard x-ray lithography, the authors have found that the conventional leadscrew driven scanner stages do not provide adequate scan speed or travel. These considerations have led the authors to develop a scanning system based on a long stroke hydraulic drive with 635 mm of travel and closed loop feedback to position the stage to better than 100 micrometers. The control of the device is through a PC with a custom LabView interface coupled to simple x-ray beam diagnostics. This configuration allows one to set a variety of scan parameters, including target dose, scan range, scan rates, and dose rate. Results from the prototype system at beamline X-27B are described as well as progress on a production version for the X-14B beamline

  8. High speed hydraulic scanner for deep x-ray lithography

    Energy Technology Data Exchange (ETDEWEB)

    Milne, J.C.; Johnson, E.D.

    1997-07-01

    From their research and development in hard x-ray lithography, the authors have found that the conventional leadscrew driven scanner stages do not provide adequate scan speed or travel. These considerations have led the authors to develop a scanning system based on a long stroke hydraulic drive with 635 mm of travel and closed loop feedback to position the stage to better than 100 micrometers. The control of the device is through a PC with a custom LabView interface coupled to simple x-ray beam diagnostics. This configuration allows one to set a variety of scan parameters, including target dose, scan range, scan rates, and dose rate. Results from the prototype system at beamline X-27B are described as well as progress on a production version for the X-14B beamline.

  9. MicroRNA-200b Suppresses Arsenic-transformed Cell Migration by Targeting Protein Kinase Cα and Wnt5b-Protein Kinase Cα Positive Feedback Loop and Inhibiting Rac1 Activation*

    Science.gov (United States)

    Wang, Zhishan; Humphries, Brock; Xiao, Hua; Jiang, Yiguo; Yang, Chengfeng

    2014-01-01

    MicroRNA-200b (miR-200b) is a member of miR-200 family that has been found to inhibit cell migration and cancer metastasis; however, the underlying mechanism is not well understood. We previously reported that miR-200 expression is depleted in arsenic-transformed human bronchial epithelial cells with highly migratory and invasive characteristics, whereas stably re-expressing miR-200b strongly suppresses arsenic-transformed cell migration. This study was performed to investigate how miR-200b inhibits arsenic-transformed cell migration. We found that protein kinase Cα (PKCα) is significantly up-regulated in arsenic-transformed cells. Combining bioinformatics analysis with PKCα 3′-untranslated region vector luciferase reporter assays, we showed that PKCα is a direct target of miR-200b. Inhibiting PKCα activity or knocking down PKCα expression drastically reduced cell migration, phenocoping the inhibitory effect of overexpressing miR-200b. In contrast, forced expression of PKCα in miR-200b overexpressing cells impaired the inhibitory effect of miR-200b on cell migration. In addition, we also found a positive feedback loop between Wnt5b and PKCα in arsenic-transformed cells. Knocking down Wnt5b expression reduced phospho-PKC levels and cell migration; and knocking down PKCα expression decreased Wnt5b level and cell migration. Moreover, forced expression of PKCα increased Wnt5b and phospho-PKC levels and cell migration. Further mechanistic studies revealed that Rac1 is highly activated in arsenic-transformed cells and stably expressing miR-200b abolishes Rac1 activation changing actin cytoskeleton organization. Manipulating PKCα or Wnt5b expression levels significantly altered the level of active Rac1. Together, these findings indicate that miR-200b suppresses arsenic-transformed cell migration by targeting PKCα and Wnt5b-PKCα positive feedback loop and subsequently inhibiting Rac1 activation. PMID:24841200

  10. MicroRNA-200b suppresses arsenic-transformed cell migration by targeting protein kinase Cα and Wnt5b-protein kinase Cα positive feedback loop and inhibiting Rac1 activation.

    Science.gov (United States)

    Wang, Zhishan; Humphries, Brock; Xiao, Hua; Jiang, Yiguo; Yang, Chengfeng

    2014-06-27

    MicroRNA-200b (miR-200b) is a member of miR-200 family that has been found to inhibit cell migration and cancer metastasis; however, the underlying mechanism is not well understood. We previously reported that miR-200 expression is depleted in arsenic-transformed human bronchial epithelial cells with highly migratory and invasive characteristics, whereas stably re-expressing miR-200b strongly suppresses arsenic-transformed cell migration. This study was performed to investigate how miR-200b inhibits arsenic-transformed cell migration. We found that protein kinase Cα (PKCα) is significantly up-regulated in arsenic-transformed cells. Combining bioinformatics analysis with PKCα 3'-untranslated region vector luciferase reporter assays, we showed that PKCα is a direct target of miR-200b. Inhibiting PKCα activity or knocking down PKCα expression drastically reduced cell migration, phenocoping the inhibitory effect of overexpressing miR-200b. In contrast, forced expression of PKCα in miR-200b overexpressing cells impaired the inhibitory effect of miR-200b on cell migration. In addition, we also found a positive feedback loop between Wnt5b and PKCα in arsenic-transformed cells. Knocking down Wnt5b expression reduced phospho-PKC levels and cell migration; and knocking down PKCα expression decreased Wnt5b level and cell migration. Moreover, forced expression of PKCα increased Wnt5b and phospho-PKC levels and cell migration. Further mechanistic studies revealed that Rac1 is highly activated in arsenic-transformed cells and stably expressing miR-200b abolishes Rac1 activation changing actin cytoskeleton organization. Manipulating PKCα or Wnt5b expression levels significantly altered the level of active Rac1. Together, these findings indicate that miR-200b suppresses arsenic-transformed cell migration by targeting PKCα and Wnt5b-PKCα positive feedback loop and subsequently inhibiting Rac1 activation. © 2014 by The American Society for Biochemistry and Molecular

  11. Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma.

    Science.gov (United States)

    Ban, J; Jug, G; Mestdagh, P; Schwentner, R; Kauer, M; Aryee, D N T; Schaefer, K-L; Nakatani, F; Scotlandi, K; Reiter, M; Strunk, D; Speleman, F; Vandesompele, J; Kovar, H

    2011-05-05

    EWS-FLI1 is a chromosome translocation-derived chimeric transcription factor that has a central and rate-limiting role in the pathogenesis of Ewing's sarcoma. Although the EWS-FLI1 transcriptomic signature has been extensively characterized on the mRNA level, information on its impact on non-coding RNA expression is lacking. We have performed a genome-wide analysis of microRNAs affected by RNAi-mediated silencing of EWS-FLI1 in Ewing's sarcoma cell lines, and differentially expressed between primary Ewing's sarcoma and mesenchymal progenitor cells. Here, we report on the identification of hsa-mir-145 as the top EWS-FLI1-repressed microRNA. Upon knockdown of EWS-FLI1, hsa-mir-145 expression dramatically increases in all Ewing's sarcoma cell lines tested. Vice versa, ectopic expression of the microRNA in Ewing's sarcoma cell lines strongly reduced EWS-FLI1 protein, whereas transfection of an anti-mir to hsa-mir-145 increased the EWS-FLI1 levels. Reporter gene assays revealed that this modulation of EWS-FLI1 protein was mediated by the microRNA targeting the FLI1 3'-untranslated region. Mutual regulations of EWS-FLI1 and hsa-mir-145 were mirrored by an inverse correlation between their expression levels in four of the Ewing's sarcoma cell lines tested. Consistent with the role of EWS-FLI1 in Ewing's sarcoma growth regulation, forced hsa-mir-145 expression halted Ewing's sarcoma cell line growth. These results identify feedback regulation between EWS-FLI1 and hsa-mir-145 as an important component of the EWS-FLI1-mediated Ewing's sarcomagenesis that may open a new avenue to future microRNA-mediated therapy of this devastating malignant disease.

  12. A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.

    Directory of Open Access Journals (Sweden)

    Miriam Sansó

    Full Text Available Transcript elongation by RNA polymerase II (RNAPII is accompanied by conserved patterns of histone modification. Whereas histone modifications have established roles in transcription initiation, their functions during elongation are not understood. Mono-ubiquitylation of histone H2B (H2Bub1 plays a key role in coordinating co-transcriptional histone modification by promoting site-specific methylation of histone H3. H2Bub1 also regulates gene expression through an unidentified, methylation-independent mechanism. Here we reveal bidirectional communication between H2Bub1 and Cdk9, the ortholog of metazoan positive transcription elongation factor b (P-TEFb, in the fission yeast Schizosaccharomyces pombe. Chemical and classical genetic analyses indicate that lowering Cdk9 activity or preventing phosphorylation of its substrate, the transcription processivity factor Spt5, reduces H2Bub1 in vivo. Conversely, mutations in the H2Bub1 pathway impair Cdk9 recruitment to chromatin and decrease Spt5 phosphorylation. Moreover, an Spt5 phosphorylation-site mutation, combined with deletion of the histone H3 Lys4 methyltransferase Set1, phenocopies morphologic and growth defects due to H2Bub1 loss, suggesting independent, partially redundant roles for Cdk9 and Set1 downstream of H2Bub1. Surprisingly, mutation of the histone H2B ubiquitin-acceptor residue relaxes the Cdk9 activity requirement in vivo, and cdk9 mutations suppress cell-morphology defects in H2Bub1-deficient strains. Genome-wide analyses by chromatin immunoprecipitation also demonstrate opposing effects of Cdk9 and H2Bub1 on distribution of transcribing RNAPII. Therefore, whereas mutual dependence of H2Bub1 and Spt5 phosphorylation indicates positive feedback, mutual suppression by cdk9 and H2Bub1-pathway mutations suggests antagonistic functions that must be kept in balance to regulate elongation. Loss of H2Bub1 disrupts that balance and leads to deranged gene expression and aberrant cell

  13. Dynamics of nonlinear feedback control

    OpenAIRE

    Snippe, H.P.; Hateren, J.H. van

    2007-01-01

    Feedback control in neural systems is ubiquitous. Here we study the mathematics of nonlinear feedback control. We compare models in which the input is multiplied by a dynamic gain (multiplicative control) with models in which the input is divided by a dynamic attenuation (divisive control). The gain signal (resp. the attenuation signal) is obtained through a concatenation of an instantaneous nonlinearity and a linear low-pass filter operating on the output of the feedback loop. For input step...

  14. Multi-bunch Feedback Systems

    OpenAIRE

    Lonza, M.; Schmickler, H.

    2016-01-01

    Coupled-bunch instabilities excited by the interaction of the particle beam with its surroundings can seriously limit the performance of circular particle accelerators. These instabilities can be cured by the use of active feedback systems based on sensors capable of detecting the unwanted beam motion and actuators that apply the feedback correction to the beam. Advances in electronic technology now allow the implementation of feedback loops using programmable digital systems. Besides importa...

  15. Control of a hydraulic system by means of a fuzzy approach

    Directory of Open Access Journals (Sweden)

    Mohamed Ksantini

    2013-07-01

    Full Text Available Non linear models can be represented conveniently by Takagi-Sugeno fuzzy models when nonlinearities are bounded. This approach uses a collection of linear models which are interpolated by non linear functions. Then the global control law is the interpolation by the same functions of each feedback associated to each linear model. A Lyapunov approach enables to compute these feedback gains. The number of linear models depends directly on the number of nonlinearities the system has. The more models there are, the more difficult it is to guarantee the stability of the closed loop. This paper proposes a method to reduce the number of linear models by assuming a number of nonlinearities considered as uncertainties and to guarantee the global exponential stability of the system. This method is applied on a hydraulic system.

  16. Development and control towards a parallel water hydraulic weld/cut robot for machining processes in ITER vacuum vessel

    International Nuclear Information System (INIS)

    Wu Huapeng; Handroos, Heikki; Pessi, Pekka; Kilkki, Juha; Jones, Lawrence

    2005-01-01

    This paper presents a special robot, able to carry out welding and machining processes from inside the ITER vacuum vessel (VV), consisting of a five degree-of-freedom parallel mechanism, mounted on a carriage driven by two electric motors on a rack. The kinematic design of the robot has been optimised for ITER access and a hydraulically actuated pre-prototype built. A hybrid controller is designed for the robot, including position, speed and pressure feedback loops to achieve high accuracy and high dynamic performances. Finally, the experimental tests are given and discussed

  17. Feedback systems in the SLC

    International Nuclear Information System (INIS)

    Thompson, K.A.; Jobe, R.K.; Johnson, R.; Phinney, N.

    1987-02-01

    Two classes of computer-controlled feedback have been implemented to stabilize parameters in subsystems of the SLC: (1) ''slow'' (time scales ∼ minutes) feedback, and (2) ''fast'', i.e., pulse-to-pulse, feedback. The slow loops run in a single FEEDBACK process in the SLC host VAX, which acquires signals and sets control parameters via communication with the database and the network of normal SLC microprocessors. Slow loops exist to stabilize beam energy and energy spread, beam position and angle, and timing of kicker magnets, and to compensate for changes in the phase length of the rf drive line. The fast loops run in dedicated microprocessors, and may sample and/or feedback on particular parameters as often as every pulse of the SLC beam. The first implementations of fast feedback are to control transverse beam blow-up and to stabilize the energy and energy spread of bunches going into the SLC arcs. The overall architecture of the feedback software and the operator interface for controlling loops are discussed

  18. Transient thermal-hydraulic/neutronic analysis in a VVER-1000 reactor core

    International Nuclear Information System (INIS)

    Seyed khalil Mousavian; Mohammad Mohsen Ertejaei; Majid Shahabfar

    2005-01-01

    Full text of publication follows: Nowadays, coupled thermal-hydraulic and three-dimensional neutronic codes in order to consider different feedback effects is state of the art subject in nuclear engineering researches. In this study, RELAP5/COBRA and WIMS/CITATION codes are implemented to investigate the VVER-1000 reactor core parameters during Large Break Loss of Coolant Accident (LB-LOCA). In a LB-LOCA, the primary side pressure, coolant density and fuel temperature strongly decrease but the cladding temperature experiences a strong peak. For this purpose, the RELAP5 Best Estimate (BE) system code is used to simulate the LB-LOCA analysis in VVER-1000 nuclear thermal-hydraulic loops. Also, the modified COBRA-IIIc software as a sub-channel analysis code is applied for modeling of VVER-1000 reactor core. Moreover, WIMS and CITATION as a cross section and 3-D neutron flux codes are coupled with thermal-hydraulic codes with the aim of consider the spatial effects through the reactor core. For this reason, suitable software is developed to link and speed up the coupled thermalhydraulic and three-dimensional neutronic calculations. This software utilizes of external coupling concept in order to integrate thermal-hydraulic and neutronic calculations. (authors)

  19. Possible hysteresis loops of resonatorless optical bistability

    International Nuclear Information System (INIS)

    Nguyen Ba An; Le Thi Cat Tuong.

    1990-05-01

    We qualitatively show that hysteresis loops of intrinsic optical bistability phenomena without any additional feedback may be of various shapes including those of a butterfly and a three-winged bow. (author). 15 refs, 4 figs

  20. Feedback Loops in Communication and Human Computing

    NARCIS (Netherlands)

    op den Akker, Hendrikus J.A.; Heylen, Dirk K.J.; Pantic, Maja; Pentland, Alex; Nijholt, Antinus; Huang, Thomas S.

    Building systems that are able to analyse communicative behaviours or take part in conversations requires a sound methodology in which the complex organisation of conversations is understood and tested on real-life samples. The data-driven approaches to human computing not only have a value for the

  1. Robust fault detection in open loop vs. closed loop

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik; Stoustrup, J.

    1997-01-01

    The robustness aspects of fault detection and isolation (FDI) for uncertain systems are considered. The FDI problem is considered in a standard problem formulation. The FDI design problem is analyzed both in the case where the control input signal is considered as a known external input signal (o...... (open loop) and when the input signal is generated by a feedback controller...

  2. [Leptin and the feedback regulation of body weight].

    Science.gov (United States)

    Wang, X; Ye, G; Sun, J

    1999-09-30

    Body weight may be controlled by a negative feedback loop. Recent studies have identified that the ob gene product, leptin, apparently and exclusively expressed in adipose tissue, is a part of the negative feedback loop. Leptin is proposed to act as an afferent signal in the negative feedback loop to hypothalamus that limiting food-intake, controlling energy homeostasis and regulating the mass of adipose tissue. The dificiency of or resistance to leptin causes severe obesity.

  3. Hydraulic manipulator

    International Nuclear Information System (INIS)

    Sinha, A.K.; Srikrishnamurty, G.

    1990-01-01

    Successful operation of nuclear plant is largely dependent on safe handling of radio-active material. In order to reduce this handling problem and minimise the exposure of radiation, various handling equipment and manipulators have been developed according to the requirements. Manufacture of nuclear fuel, which is the most important part of the nuclear industry, involves handling of uranium ingots weighing approximately 250 kg. This paper describes a specially designed hydraulic manipulator for handling of the ingots in a limited space. It was designed to grab and handle the ingots in any position. This has following drive motions: (1)gripping and releasing, (2)lifting and lowering (z-motion), (3)rotation about the horizontal axis (azimuth drive), (4)rotation about the job axis, and (5)rotation about the vertical axis. For horizontal motion (X and Y axis motion) this equipment is mounted on a motorised trolley, so that it can move inside the workshop. For all drives except the rotation about the job axis, hydraulic cylinders have been used with a battery operated power pack. Trolley drive is also given power from same battery. This paper describes the design aspects of this manipulator. (author). 4 figs

  4. Generalized fast feedback system in the SLC

    International Nuclear Information System (INIS)

    Hendrickson, L.; Allison, S.; Gromme, T.; Himel, T.; Krauter, K.; Rouse, F.; Sass, R.; Shoaee, H.

    1992-01-01

    A generalized fast feedback system has been developed to stabilize beams at various locations in the SLC. The system is designed to perform measurements and change actuator settings to control beam states such as position, angle and energy on a pulse to pulse basis. The software design is based on the state space formalism of digital control theory. The system is database-driven, facilitating the addition of new loops without requiring additional software. A communications system, KISNet, provides fast communications links between microprocessors for feedback loops which involve multiple micros. Feedback loops have been installed in seventeen locations throughout the SLC and have proven to be invaluable in stabilizing the machine. (author)

  5. Generalized fast feedback system in the SLC

    International Nuclear Information System (INIS)

    Hendrickson, L.; Allison, S.; Gromme, T.; Himel, T.; Krauter, K.; Rouse, F.; Sass, R.; Shoaee, H.

    1991-11-01

    A generalized fast feedback system has been developed to stabilize beams at various locations in the SLC. The system is designed to perform measurements and change actuator settings to control beam states such as position, angle and energy on a pulse to pulse basis. The software design is based on the state space formalism of digital control theory. The system is database-driven, facilitating the addition of new loops without requiring additional software. A communications system, KISNet, provides fast communications links between microprocessors for feedback loops which involve multiple micros. Feedback loops have been installed in seventeen locations throughout the SLC and have proven to be invaluable in stabilizing the machine

  6. Klystron equalization for RF feedback

    International Nuclear Information System (INIS)

    Corredoura, P.

    1993-01-01

    The next generation of colliding beam storage rings support higher luminosities by significantly increasing the number of bunches and decreasing the spacing between respective bunches. The heavy beam loading requires large RF cavity detuning which drives several lower coupled bunch modes very strongly. One technique which has proven to be very successful in reducing the coupled bunch mode driving impedance is RF feedback around the klystron-cavity combination. The gain and bandwidth of the feedback loop is limited by the group delay around the feedback loop. Existing klystrons on the world market have not been optimized for this application and contribute a large portion of the total loop group delay. This paper describes a technique to reduce klystron group delay by adding an equalizing filter to the klystron RF drive. Such a filter was built and tested on a 500 kill klystron as part of the on going PEP-II R ampersand D effort here at SLAC

  7. Model predictive control-based dynamic coordinate strategy for hydraulic hub-motor auxiliary system of a heavy commercial vehicle

    Science.gov (United States)

    Zeng, Xiaohua; Li, Guanghan; Yin, Guodong; Song, Dafeng; Li, Sheng; Yang, Nannan

    2018-02-01

    Equipping a hydraulic hub-motor auxiliary system (HHMAS), which mainly consists of a hydraulic variable pump, a hydraulic hub-motor, a hydraulic valve block and hydraulic accumulators, with part-time all-wheel-drive functions improves the power performance and fuel economy of heavy commercial vehicles. The coordinated control problem that occurs when HHMAS operates in the auxiliary drive mode is addressed in this paper; the solution to this problem is the key to the maximization of HHMAS. To achieve a reasonable distribution of the engine power between mechanical and hydraulic paths, a nonlinear control scheme based on model predictive control (MPC) is investigated. First, a nonlinear model of HHMAS with vehicle dynamics and tire slip characteristics is built, and a controller-design-oriented model is simplified. Then, a steady-state feedforward + dynamic MPC feedback controller (FMPC) is designed to calculate the control input sequence of engine torque and hydraulic variable pump displacement. Finally, the controller is tested in the MATLAB/Simulink and AMESim co-simulation platform and the hardware-in-the-loop experiment platform, and its performance is compared with that of the existing proportional-integral-derivative controller and the feedforward controller under the same conditions. Simulation results show that the designed FMPC has the best performance, and control performance can be guaranteed in a real-time environment. Compared with the tracking control error of the feedforward controller, that of the designed FMPC is decreased by 85% and the traction efficiency performance is improved by 23% under a low-friction-surface condition. Moreover, under common road conditions for heavy commercial vehicles, the traction force can increase up to 13.4-15.6%.

  8. RF feedback development for the PEP-II B Factory

    Energy Technology Data Exchange (ETDEWEB)

    Corredoura, P.; Sapozhnikov, L.; Tighe, R.

    1994-06-01

    In PEP-II heavy beam loading along with a relatively long revolution period combine to strongly drive lower coupled-bunch modes through interaction with the fundamental cavity mode. Feedback techniques can be applied to reduce the cavity impedance seen by the beam. Several RF feedback loops are planned to reduce the growth rates down to a level which can be damped by the relatively low power bunch-by-bunch longitudinal feedback system. This paper describes the RF feedback loops as well as hardware tests using a 500 kW klystron, analog and digital feedback loops, and a low power test cavity.

  9. RF feedback development for the PEP-II B Factory

    International Nuclear Information System (INIS)

    Corredoura, P.; Sapozhnikov, L.; Tighe, R.

    1994-06-01

    In PEP-II heavy beam loading along with a relatively long revolution period combine to strongly drive lower coupled-bunch modes through interaction with the fundamental cavity mode. Feedback techniques can be applied to reduce the cavity impedance seen by the beam. Several RF feedback loops are planned to reduce the growth rates down to a level which can be damped by the relatively low power bunch-by-bunch longitudinal feedback system. This paper describes the RF feedback loops as well as hardware tests using a 500 kW klystron, analog and digital feedback loops, and a low power test cavity

  10. A Computational Model of Hydraulic Volume Displacement Drive

    Directory of Open Access Journals (Sweden)

    V. N. Pil'gunov

    2014-01-01

    Full Text Available The paper offers a computational model of industrial-purpose hydraulic drive with two hydraulic volume adjustable working chamber machines (pump and motor. Adjustable pump equipped with the pressure control unit can be run together with several adjustable hydraulic motors on the principle of three-phase hydraulic socket-outlet with high-pressure lines, drain, and drainage system. The paper considers the pressure-controlled hydrostatic transmission with hydraulic motor as an output link. It shows a possibility to create a saving hydraulic drive using a functional tie between the adjusting parameters of the pump and hydraulic motor through the pressure difference, torque, and angular rate of the hydraulic motor shaft rotation. The programmable logic controller can implement such tie. The Coulomb and viscous frictions are taken into consideration when developing a computational model of the hydraulic volume displacement drive. Discharge balance considers external and internal leakages in equivalent clearances of hydraulic machines, as well as compression loss volume caused by hydraulic fluid compressibility and deformation of pipe walls. To correct dynamic properties of hydraulic drive, the paper offers that in discharge balance are included the additional regulated external leakages in the open circuit of hydraulic drive and regulated internal leakages in the closed-loop circuit. Generalized differential equations having functional multipliers and multilinked nature have been obtained to describe the operation of hydraulic positioning and speed drive with two hydraulic volume adjustable working chamber machines. It is shown that a proposed computational model of hydraulic drive can be taken into consideration in development of LS («Load-Sensing» drives, in which the pumping pressure is tuned to the value required for the most loaded slave motor to overcome the load. Results attained can be used both in designing the industrial-purpose heavy

  11. Thermal-hydraulic analysis of the improved TOPAZ-II power system using a heat pipe radiator

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Wenwen; Zhang, Dalin, E-mail: dlzhang@mail.xjtu.edu.cn; Tian, Wenxi; Qiu, Suizheng; Su, G.H.

    2016-10-15

    Highlights: • The system thermal-hydraulic model of the improved space thermionic reactor is developed. • The temperature reactivity feedback effects of the moderator, UO2 fuel, electrodes and reflector are considered. • The alkali metal heat pipe radiator is modeled with the two dimensional heat pipe model. • The steady state and the start-up procedure of the system are analyzed. - Abstract: A system analysis code coupled with the heat pipe model is developed to analyze the thermal-hydraulic characteristics of the improved TOPAZ-II reactor power system with a heat pipe radiator. The core thermal-hydraulic model, neutron physics model, and the coolant loop component models (including pump, volume accumulator, pipes and plenums) are established. The designed heat pipe radiator, which replaces the original pumped loop radiator, is also modeled, including two-dimensional heat pipe analysis model, fin model and coolant transport duct model. The system analysis code and the heat pipe model is coupled in the transport duct model. Steady state condition and start-up procedure of the improved TOPAZ-II system are calculated. The results show that the designed radiator can satisfy the waste heat rejection requirement of the improved power system. Meanwhile, the code can be used to obtained the thermal characteristics of the system transients such as the start-up process.

  12. MAESTRO, a hydraulic manipulator for maintenance and decommissioning applications

    International Nuclear Information System (INIS)

    Olivier David; Yvan Measson; Catherine Bidard; Christine Libersa

    2006-01-01

    Compared to electric technology payload of hydraulic manipulators is very high with respect to their volume and mass. However, due to their force control limitations they were usually disqualified for precise manipulation. CEA, in collaboration with CYBERNETIX developed a complete remote handling system around the advanced hydraulic robotic arm MAESTRO. Requirements and specifications of the system were defined according to the needs of decommissioning activities in existing nuclear facilities and maintenance scenarios of the next step fusion reactor ITER. Using TAO2000 CEA controller, CEA developed specific force control loops to improve the performances of the manipulator and reach a level where the MAESTRO can be used like a traditional tele-operation master/slave system with force feedback. The complete system is composed of a 2 m long 100 kg payload 6 degrees of freedom slave hydraulic manipulator. The manipulator is mounted on an embedded unit made of a 210 bars hydraulic power pack and a 10 kGy rad hardened slave controller. The master station is made of the new generation Virtuose V6D-40-40 master arm with its TAO2000 controller. The graphical supervisor Magritte gives the operator an additional interface to manage and monitor the system. Repetitive tasks like tool picking can therefore be left to the system while the operator keeps his concentration on the main task. Thanks to the collision detection algorithm, Magritte warns the operator when the tool or any part of the Maestro arm comes too close to a delicate unit. Operational experience gained through test campaigns was gathered in an upgrade study to propose a new version of the manipulator that successfully ran through a 1000 hour endurance test. Rad-hardened components were selected and tested in nuclear facilities. Attention was paid to provide a design in which contamination is easily removed and to ease the maintenance when performed by an operator in suit. To be quickly adapted to new tasks, the

  13. Analysis of PBMR transients using a coupled neutron transport/thermal-hydraulics code DORT-TD/thermix

    International Nuclear Information System (INIS)

    Tyobeka, B.; Ivanov, K.; Pautz, A.

    2007-01-01

    In the advent of increased demand for safety and economics of nuclear power plants, nuclear engineers and designers are called upon to develop advanced computation tools. In these developments, space-time effects in the dynamics of nuclear reactors must be considered within the framework of a full 3-dimensional treatment of both neutron kinetics and thermal hydraulics. In a recent effort at the Pennsylvania State University, a time-dependent version of the discrete ordinates transport code DORT, DORT-TD was coupled to a 2-dimensional core thermal hydraulics code THERMIX-DIREKT. In the coupling process, a feedback model was developed to account for the feedback effects and was implemented into DORT-TD. During the calculation process for each spatial node of the DORT-TD core model, feedback parameters representative of this node are passed to the feedback module. Using these values, cross section tables are then interpolated for the appropriate macroscopic cross section values. The updated macroscopic cross sections are passed back to DORT-TD to perform transport core calculations, and the power distribution is transferred to THERMIX-DIREKT to obtain the relevant thermal-hydraulics data in turn, and this calculation loop continues. In this paper, DORT-TD/THERMIX is used to simulate transients of interest in the PBMR (Pebble Bed Modular Reactor) safety using established benchmark problems: load change from 100% to 40% power and fast control rod ejection (PBMR-268 benchmark problem). The results obtained are compared with those obtained using the diffusion-based module of the code. The results are only preliminary and so far show that diffusion theory is not such a bad approximation for PBMR for the prediction of integral parameters

  14. Pulsed feedback defers cellular differentiation.

    Directory of Open Access Journals (Sweden)

    Joe H Levine

    2012-01-01

    Full Text Available Environmental signals induce diverse cellular differentiation programs. In certain systems, cells defer differentiation for extended time periods after the signal appears, proliferating through multiple rounds of cell division before committing to a new fate. How can cells set a deferral time much longer than the cell cycle? Here we study Bacillus subtilis cells that respond to sudden nutrient limitation with multiple rounds of growth and division before differentiating into spores. A well-characterized genetic circuit controls the concentration and phosphorylation of the master regulator Spo0A, which rises to a critical concentration to initiate sporulation. However, it remains unclear how this circuit enables cells to defer sporulation for multiple cell cycles. Using quantitative time-lapse fluorescence microscopy of Spo0A dynamics in individual cells, we observed pulses of Spo0A phosphorylation at a characteristic cell cycle phase. Pulse amplitudes grew systematically and cell-autonomously over multiple cell cycles leading up to sporulation. This pulse growth required a key positive feedback loop involving the sporulation kinases, without which the deferral of sporulation became ultrasensitive to kinase expression. Thus, deferral is controlled by a pulsed positive feedback loop in which kinase expression is activated by pulses of Spo0A phosphorylation. This pulsed positive feedback architecture provides a more robust mechanism for setting deferral times than constitutive kinase expression. Finally, using mathematical modeling, we show how pulsing and time delays together enable "polyphasic" positive feedback, in which different parts of a feedback loop are active at different times. Polyphasic feedback can enable more accurate tuning of long deferral times. Together, these results suggest that Bacillus subtilis uses a pulsed positive feedback loop to implement a "timer" that operates over timescales much longer than a cell cycle.

  15. Dynamics of nonlinear feedback control.

    Science.gov (United States)

    Snippe, H P; van Hateren, J H

    2007-05-01

    Feedback control in neural systems is ubiquitous. Here we study the mathematics of nonlinear feedback control. We compare models in which the input is multiplied by a dynamic gain (multiplicative control) with models in which the input is divided by a dynamic attenuation (divisive control). The gain signal (resp. the attenuation signal) is obtained through a concatenation of an instantaneous nonlinearity and a linear low-pass filter operating on the output of the feedback loop. For input steps, the dynamics of gain and attenuation can be very different, depending on the mathematical form of the nonlinearity and the ordering of the nonlinearity and the filtering in the feedback loop. Further, the dynamics of feedback control can be strongly asymmetrical for increment versus decrement steps of the input. Nevertheless, for each of the models studied, the nonlinearity in the feedback loop can be chosen such that immediately after an input step, the dynamics of feedback control is symmetric with respect to increments versus decrements. Finally, we study the dynamics of the output of the control loops and find conditions under which overshoots and undershoots of the output relative to the steady-state output occur when the models are stimulated with low-pass filtered steps. For small steps at the input, overshoots and undershoots of the output do not occur when the filtering in the control path is faster than the low-pass filtering at the input. For large steps at the input, however, results depend on the model, and for some of the models, multiple overshoots and undershoots can occur even with a fast control path.

  16. Multi-bunch feedback systems

    CERN Document Server

    Lonza, M

    2008-01-01

    Coupled-bunch instabilities excited by the interaction of the particle beam with its surroundings can seriously limit the performance of circular particle accelerators. These instabilities can be cured by the use of active feedback systems based on sensors capable of detecting the unwanted beam motion and actuators that apply the feedback correction to the beam. The advances in electronic technology now allow the implementation of feedback loops using programmable digital systems. Besides important advantages in terms of flexibility and reproducibility, digital systems open the way to the use of novel diagnostic tools and additional features. The lecture will first introduce coupled-bunch instabilities analysing the equation of motion of charged particles and the different modes of oscillation of a multi-bunch beam, showing how they can be observed and measured. Different types of feedbacks systems will then be presented as examples of real implementations that belong to the history of multi-bunch feedback sy...

  17. Multi-bunch Feedback Systems

    CERN Document Server

    Lonza, M.

    2014-12-19

    Coupled-bunch instabilities excited by the interaction of the particle beam with its surroundings can seriously limit the performance of circular particle accelerators. These instabilities can be cured by the use of active feedback systems based on sensors capable of detecting the unwanted beam motion and actuators that apply the feedback correction to the beam. Advances in electronic technology now allow the implementation of feedback loops using programmable digital systems. Besides important advantages in terms of flexibility and reproducibility, digital systems open the way to the use of novel diagnostic tools and additional features. We first introduce coupled-bunch instabilities, analysing the equation of motion of charged particles and the different modes of oscillation of a multi-bunch beam, showing how they can be observed and measured. Different types of feedback systems will then be presented as examples of real implementations that belong to the history of multi-bunch feedback systems. The main co...

  18. Feedback control of atomic motion in an optical lattice

    International Nuclear Information System (INIS)

    Morrow, N.V.; Dutta, S.K.; Raithel, G.

    2002-01-01

    We demonstrate a real-time feedback scheme to manipulate wave-packet oscillations of atoms in an optical lattice. The average position of the atoms in the lattice wells is measured continuously and nondestructively. A feedback loop processes the position signal and translates the lattice potential. Depending on the feedback loop characteristics, we find amplification, damping, or an entire alteration of the wave-packet oscillations. Our results are well supported by simulations

  19. Approximate Models for Closed-Loop Trajectory Tracking in Underactuated Systems

    Data.gov (United States)

    National Aeronautics and Space Administration — Control of robotic systems, as a field, spans both traditional closed-loop feedback techniques and modern machine learning strategies, which are primarily open-loop....

  20. Formativ Feedback

    DEFF Research Database (Denmark)

    Hyldahl, Kirsten Kofod

    Denne bog undersøger, hvordan lærere kan anvende feedback til at forbedre undervisningen i klasselokalet. I denne sammenhæng har John Hattie, professor ved Melbourne Universitet, udviklet en model for feedback, hvilken er baseret på synteser af meta-analyser. I 2009 udgav han bogen "Visible...

  1. Operation of the nuclear fuel cycle test facilities -Operation of the hot test loop facilities

    International Nuclear Information System (INIS)

    Chun, S. Y.; Jeong, M. K.; Park, C. K.; Yang, S. K.; Won, S. Y.; Song, C. H.; Jeon, H. K.; Jeong, H. J.; Cho, S.; Min, K. H.; Jeong, J. H.

    1997-01-01

    A performance and reliability of a advanced nuclear fuel and reactor newly designed should be verified by performing the thermal hydraulics tests. In thermal hydraulics research team, the thermal hydraulics tests associated with the development of an advanced nuclear fuel and reactor haven been carried out with the test facilities, such as the Hot Test Loop operated under high temperature and pressure conditions, Cold Test Loop, RCS Loop and B and C Loop. The objective of this project is to obtain the available experimental data and to develop the advanced measuring techniques through taking full advantage of the facilities. The facilities operated by the thermal hydraulics research team have been maintained and repaired in order to carry out the thermal hydraulics tests necessary for providing the available data. The performance tests for the double grid type bottom end piece which was improved on the debris filtering effectivity were performed using the PWR-Hot Test Loop. The CANDU-Hot Test Loop was operated to carry out the pressure drop tests and strength tests of CANFLEX fuel. The Cold Test Loop was used to obtain the local velocity data in subchannel within HANARO fuel bundle and to study a thermal mixing characteristic of PWR fuel bundle. RCS thermal hydraulic loop was constructed and the experiments have been carried out to measure the critical heat flux. In B and C Loop, the performance tests for each component were carried out. (author). 19 tabs., 78 figs., 19 refs

  2. Operation of the nuclear fuel cycle test facilities -Operation of the hot test loop facilities

    Energy Technology Data Exchange (ETDEWEB)

    Chun, S. Y.; Jeong, M. K.; Park, C. K.; Yang, S. K.; Won, S. Y.; Song, C. H.; Jeon, H. K.; Jeong, H. J.; Cho, S.; Min, K. H.; Jeong, J. H.

    1997-01-01

    A performance and reliability of a advanced nuclear fuel and reactor newly designed should be verified by performing the thermal hydraulics tests. In thermal hydraulics research team, the thermal hydraulics tests associated with the development of an advanced nuclear fuel and reactor haven been carried out with the test facilities, such as the Hot Test Loop operated under high temperature and pressure conditions, Cold Test Loop, RCS Loop and B and C Loop. The objective of this project is to obtain the available experimental data and to develop the advanced measuring techniques through taking full advantage of the facilities. The facilities operated by the thermal hydraulics research team have been maintained and repaired in order to carry out the thermal hydraulics tests necessary for providing the available data. The performance tests for the double grid type bottom end piece which was improved on the debris filtering effectivity were performed using the PWR-Hot Test Loop. The CANDU-Hot Test Loop was operated to carry out the pressure drop tests and strength tests of CANFLEX fuel. The Cold Test Loop was used to obtain the local velocity data in subchannel within HANARO fuel bundle and to study a thermal mixing characteristic of PWR fuel bundle. RCS thermal hydraulic loop was constructed and the experiments have been carried out to measure the critical heat flux. In B and C Loop, the performance tests for each component were carried out. (author). 19 tabs., 78 figs., 19 refs.

  3. Hydraulic Hybrid Vehicles

    Science.gov (United States)

    EPA and the United Parcel Service (UPS) have developed a hydraulic hybrid delivery vehicle to explore and demonstrate the environmental benefits of the hydraulic hybrid for urban pick-up and delivery fleets.

  4. Multi-bunch Feedback Systems

    International Nuclear Information System (INIS)

    Lonza, M; Schmickler, H

    2014-01-01

    Coupled-bunch instabilities excited by the interaction of the particle beam with its surroundings can seriously limit the performance of circular particle accelerators. These instabilities can be cured by the use of active feedback systems based on sensors capable of detecting the unwanted beam motion and actuators that apply the feedback correction to the beam. Advances in electronic technology now allow the implementation of feedback loops using programmable digital systems. Besides important advantages in terms of flexibility and reproducibility, digital systems open the way to the use of novel diagnostic tools and additional features. We first introduce coupled-bunch instabilities, analysing the equation of motion of charged particles and the different modes of oscillation of a multi-bunch beam, showing how they can be observed and measured. Different types of feedback systems will then be presented as examples of real implementations that belong to the history of multi-bunch feedback systems. The main components of a feedback system and the related issues will also be analysed. Finally, we shall focus on digital feedback systems, their characteristics, and features, as well as on how they can be concretely exploited for both the optimization of feedback performance and for beam dynamics studies

  5. Feedback Networks

    OpenAIRE

    Zamir, Amir R.; Wu, Te-Lin; Sun, Lin; Shen, William; Malik, Jitendra; Savarese, Silvio

    2016-01-01

    Currently, the most successful learning models in computer vision are based on learning successive representations followed by a decision layer. This is usually actualized through feedforward multilayer neural networks, e.g. ConvNets, where each layer forms one of such successive representations. However, an alternative that can achieve the same goal is a feedback based approach in which the representation is formed in an iterative manner based on a feedback received from previous iteration's...

  6. Kalman Orbit Optimized Loop Tracking

    Science.gov (United States)

    Young, Lawrence E.; Meehan, Thomas K.

    2011-01-01

    Under certain conditions of low signal power and/or high noise, there is insufficient signal to noise ratio (SNR) to close tracking loops with individual signals on orbiting Global Navigation Satellite System (GNSS) receivers. In addition, the processing power available from flight computers is not great enough to implement a conventional ultra-tight coupling tracking loop. This work provides a method to track GNSS signals at very low SNR without the penalty of requiring very high processor throughput to calculate the loop parameters. The Kalman Orbit-Optimized Loop (KOOL) tracking approach constitutes a filter with a dynamic model and using the aggregate of information from all tracked GNSS signals to close the tracking loop for each signal. For applications where there is not a good dynamic model, such as very low orbits where atmospheric drag models may not be adequate to achieve the required accuracy, aiding from an IMU (inertial measurement unit) or other sensor will be added. The KOOL approach is based on research JPL has done to allow signal recovery from weak and scintillating signals observed during the use of GPS signals for limb sounding of the Earth s atmosphere. That approach uses the onboard PVT (position, velocity, time) solution to generate predictions for the range, range rate, and acceleration of the low-SNR signal. The low- SNR signal data are captured by a directed open loop. KOOL builds on the previous open loop tracking by including feedback and observable generation from the weak-signal channels so that the MSR receiver will continue to track and provide PVT, range, and Doppler data, even when all channels have low SNR.

  7. Hydraulic Hybrid Propulsion for Heavy Vehicles: Combining the Simulation and Engine-In-the-Loop Techniques to Maximize the Fuel Economy and Emission Benefits Propulsion hybride hydraulique des poids lourds : une approche alliant les techniques de simulation et d’« Engine-In-the-loop » (EIL afin de maximiser les économies de carburant et les avantages en termes d’émissions

    Directory of Open Access Journals (Sweden)

    Filipi Z.

    2009-09-01

    Full Text Available The global energy situation, the dependence of the transportation sector on fossil fuels, and a need for a rapid response to the global warming challenge, provide a strong impetus for development of fuel efficient vehicle propulsion. The task is particularly challenging in the case of trucks due to severe weight/size constraints. Hybridization is the only approach offering significant breakthroughs in near and mid-term. In particular, the series configuration decouples the engine from the wheels and allows full flexibility in controlling the engine operation, while the hydraulic energy conversion and storage provides exceptional power density and efficiency. The challenge stems from a relatively low energy density of the hydraulic accumulator. This places particular emphasis on development of the supervisory controller. The conventional wisdom is to operate the engine at the “sweet spot”, but the aggressive pursuit of engine efficiency as the sole objective can lead to frequent and rapid diesel engine transients, thus causing an adverse affect on the soot emissions and driver feel. Therefore, we propose a comprehensive methodology for considering a combined hybrid system fuel-economy and emissions objective. The fuel economy is addressed with the simulation-based approach, while investigating the impact of engine transients on particulate emission relies on the Engine-In-the-loop (EIL capability. The EIL study confirms advantages of a modulated state-of-charge control over the thermostatic approach, and demonstrates the ability of the Series Hydraulic Hybrid to improve the fuel economy of the medium truck by 72%, while reducing the particulate emission by 74% compared to the conventional baseline over the city driving schedule. La situation énergétique mondiale, la dépendance du secteur des transports vis-à-vis des combustibles d’origine fossile et la nécessité d’une réponse rapide face au défi présenté par le r

  8. Identification and robust water level control of horizontal steam generators using quantitative feedback theory

    International Nuclear Information System (INIS)

    Safarzadeh, O.; Khaki-Sedigh, A.; Shirani, A.S.

    2011-01-01

    Highlights: → A robust water level controller for steam generators (SGs) is designed based on the Quantitative Feedback Theory. → To design the controller, fairly accurate linear models are identified for the SG. → The designed controller is verified using a developed novel global locally linear neuro-fuzzy model of the SG. → Both of the linear and nonlinear models are based on the SG mathematical thermal-hydraulic model developed using the simulation computer code. → The proposed method is easy to apply and guarantees desired closed loop performance. - Abstract: In this paper, a robust water level control system for the horizontal steam generator (SG) using the quantitative feedback theory (QFT) method is presented. To design a robust QFT controller for the nonlinear uncertain SG, control oriented linear models are identified. Then, the nonlinear system is modeled as an uncertain linear time invariant (LTI) system. The robust designed controller is applied to the nonlinear plant model. This nonlinear model is based on a locally linear neuro-fuzzy (LLNF) model. This model is trained using the locally linear model tree (LOLIMOT) algorithm. Finally, simulation results are employed to show the effectiveness of the designed QFT level controller. It is shown that it will ensure the entire designer's water level closed loop specifications.

  9. Identification and robust water level control of horizontal steam generators using quantitative feedback theory

    Energy Technology Data Exchange (ETDEWEB)

    Safarzadeh, O., E-mail: O_Safarzadeh@sbu.ac.ir [Shahid Beheshti University, P.O. Box: 19839-63113, Tehran (Iran, Islamic Republic of); Khaki-Sedigh, A. [K. N. Toosi University of Technology, Tehran (Iran, Islamic Republic of); Shirani, A.S. [Shahid Beheshti University, P.O. Box: 19839-63113, Tehran (Iran, Islamic Republic of)

    2011-09-15

    Highlights: {yields} A robust water level controller for steam generators (SGs) is designed based on the Quantitative Feedback Theory. {yields} To design the controller, fairly accurate linear models are identified for the SG. {yields} The designed controller is verified using a developed novel global locally linear neuro-fuzzy model of the SG. {yields} Both of the linear and nonlinear models are based on the SG mathematical thermal-hydraulic model developed using the simulation computer code. {yields} The proposed method is easy to apply and guarantees desired closed loop performance. - Abstract: In this paper, a robust water level control system for the horizontal steam generator (SG) using the quantitative feedback theory (QFT) method is presented. To design a robust QFT controller for the nonlinear uncertain SG, control oriented linear models are identified. Then, the nonlinear system is modeled as an uncertain linear time invariant (LTI) system. The robust designed controller is applied to the nonlinear plant model. This nonlinear model is based on a locally linear neuro-fuzzy (LLNF) model. This model is trained using the locally linear model tree (LOLIMOT) algorithm. Finally, simulation results are employed to show the effectiveness of the designed QFT level controller. It is shown that it will ensure the entire designer's water level closed loop specifications.

  10. Operation of the hot test loop facilities

    International Nuclear Information System (INIS)

    Cheong, Moon Ki; Park, Choon Kyeong; Won, Soon Yeon; Yang, Sun Kyu; Cheong, Jang Whan; Cheon, Se Young; Song, Chul Hwa; Jeon, Hyeong Kil; Chang, Suk Kyu; Jeong, Heung Jun; Cho, Young Ro; Kim, Bok Duk; Min, Kyeong Ho

    1994-12-01

    The objective of this project is to obtain the available experimental data and to develop the measuring techniques through taking full advantage of the facilities. The facilities operated by the thermal hydraulics department have been maintained and repaired in order to carry out the thermal hydraulics tests necessary for providing the available data. The performance tests for double grid type bottom end piece which was improved on the debris filtering effectivity were performed using the PWR-Hot Test Loop. The CANDU-Hot Test Loop was operated to carry out the pressure drop tests and strength tests of fuel. The Cold Test Loop was used to obtain the local velocity data in subchannel within fuel bundle and to understand the characteristic of pressure drop required for improving the nuclear fuel and to develop the advanced measuring techniques. RCS Loop, which is used to measure the CHF, is presently under design and construction. B and C Loop is designed and constructed to assess the automatic depressurization safety system behavior. 4 tabs., 79 figs., 7 refs. (Author) .new

  11. Parallelizing More Loops with Compiler Guided Refactoring

    DEFF Research Database (Denmark)

    Larsen, Per; Ladelsky, Razya; Lidman, Jacob

    2012-01-01

    an interactive compilation feedback system that guides programmers in iteratively modifying their application source code. This helps leverage the compiler’s ability to generate loop-parallel code. We employ our system to modify two sequential benchmarks dealing with image processing and edge detection...

  12. Self-oscillating loop based piezoelectric power converter

    DEFF Research Database (Denmark)

    2013-01-01

    The present invention relates to a piezoelectric power converter comprising an input driver electrically coupled directly to an input or primary electrode of the piezoelectric transformer without any intervening series or parallel inductor. A feedback loop is operatively coupled between an output......- oscillation loop within a zero-voltage-switching (ZVS) operation range of the piezoelectric transformer....

  13. Active fault diagnosis in closed-loop systems

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik; Poulsen, Niels Kjølstad

    2005-01-01

    Active fault diagnosis (AFD) of parametric faults is considered in connection with closed loop feedback systems. AFD involves auxiliary signals applied on the closed loop system. A fault signature matrix is introduced in connection with AFD and it is shown that if a limited number of faults can...

  14. Alternative loop rings

    CERN Document Server

    Goodaire, EG; Polcino Milies, C

    1996-01-01

    For the past ten years, alternative loop rings have intrigued mathematicians from a wide cross-section of modern algebra. As a consequence, the theory of alternative loop rings has grown tremendously. One of the main developments is the complete characterization of loops which have an alternative but not associative, loop ring. Furthermore, there is a very close relationship between the algebraic structures of loop rings and of group rings over 2-groups. Another major topic of research is the study of the unit loop of the integral loop ring. Here the interaction between loop rings and group ri

  15. Thermally Actuated Hydraulic Pumps

    Science.gov (United States)

    Jones, Jack; Ross, Ronald; Chao, Yi

    2008-01-01

    Thermally actuated hydraulic pumps have been proposed for diverse applications in which direct electrical or mechanical actuation is undesirable and the relative slowness of thermal actuation can be tolerated. The proposed pumps would not contain any sliding (wearing) parts in their compressors and, hence, could have long operational lifetimes. The basic principle of a pump according to the proposal is to utilize the thermal expansion and contraction of a wax or other phase-change material in contact with a hydraulic fluid in a rigid chamber. Heating the chamber and its contents from below to above the melting temperature of the phase-change material would cause the material to expand significantly, thus causing a substantial increase in hydraulic pressure and/or a substantial displacement of hydraulic fluid out of the chamber. Similarly, cooling the chamber and its contents from above to below the melting temperature of the phase-change material would cause the material to contract significantly, thus causing a substantial decrease in hydraulic pressure and/or a substantial displacement of hydraulic fluid into the chamber. The displacement of the hydraulic fluid could be used to drive a piston. The figure illustrates a simple example of a hydraulic jack driven by a thermally actuated hydraulic pump. The pump chamber would be a cylinder containing encapsulated wax pellets and containing radial fins to facilitate transfer of heat to and from the wax. The plastic encapsulation would serve as an oil/wax barrier and the remaining interior space could be filled with hydraulic oil. A filter would retain the encapsulated wax particles in the pump chamber while allowing the hydraulic oil to flow into and out of the chamber. In one important class of potential applications, thermally actuated hydraulic pumps, exploiting vertical ocean temperature gradients for heating and cooling as needed, would be used to vary hydraulic pressures to control buoyancy in undersea research

  16. ProMES: A method for "accepted control loops"

    NARCIS (Netherlands)

    Tuijl, van H.F.J.M.

    1997-01-01

    ProMES, a method for the measurement and feedback of performance data is related to the concepts of goal setting and feedback (Locke, 1991; Locke and Latham, 1990), and to the concept of self-control (Bandura, 1991). The result is a model for self-management: the "accepted control loop". Whether

  17. Digital switched hydraulics

    Science.gov (United States)

    Pan, Min; Plummer, Andrew

    2018-06-01

    This paper reviews recent developments in digital switched hydraulics particularly the switched inertance hydraulic systems (SIHSs). The performance of SIHSs is presented in brief with a discussion of several possible configurations and control strategies. The soft switching technology and high-speed switching valve design techniques are discussed. Challenges and recommendations are given based on the current research achievements.

  18. Hydraulic Structures : Caissons

    NARCIS (Netherlands)

    Voorendt, M.Z.; Molenaar, W.F.; Bezuyen, K.G.

    These lecture notes on caissons are part of the study material belonging to the course 'Hydraulic Structures 1' (code CTB3355), part of the Bachelor of Science education and the Hydraulic Engineering track of the Master of Science education for civil engineering students at Delft University of

  19. Operation of the transverse feedback system at the CERN SPS

    International Nuclear Information System (INIS)

    Bossart, R.; Louwerse, R.; Mourier, J.; Vos, L.

    1987-01-01

    To prevent transverse instabilities at high beam intensity in the SPS, the transverse feedback system for damping the betatron oscillations has been upgraded for larger damping decrements and for increased system's bandwidth. The feedback loop now contains a digital delay line cancellor, so that the damper works with a velocity feedback Δx/Δt, unaffected by the closed orbit position x at the pick-up station. The digital processing of the feedback signal facilitates nonlinear feedback techniques such as antidamping and ''band-bang'' feedback. The ''bang-bang'' feedback provides the maximum possible damping rate of the injection oscillations in the SPS-collider, in order to minimize the emittance increase caused by filamentation. The antidamping nonlinearity provides small continuous beam oscillations of 50 μm amplitude for tracking the machine tune Q with a phase locked loop

  20. Current control loop design and analysis based on resonant regulators for microgrid applications

    DEFF Research Database (Denmark)

    Federico, de Bosio; Pastorelli, Michelle; de Sousa Ribeiro, Luiz Antonio

    2015-01-01

    Voltage and current control loops play an important role in the performance of microgrids employing power electronics voltage source inverters. Correct design of feedback loops is essential for the proper operation of these systems. This paper analyzes the influence of state feedback cross......-coupling in the design of resonant regulators for inner current loops in power converters operating in standalone microgrids. It is also demonstrated that the effect of state feedback cross-coupling degrades the performance of the control loops by increasing the steady-state error. Different resonant regulators...

  1. Vibration of hydraulic machinery

    CERN Document Server

    Wu, Yulin; Liu, Shuhong; Dou, Hua-Shu; Qian, Zhongdong

    2013-01-01

    Vibration of Hydraulic Machinery deals with the vibration problem which has significant influence on the safety and reliable operation of hydraulic machinery. It provides new achievements and the latest developments in these areas, even in the basic areas of this subject. The present book covers the fundamentals of mechanical vibration and rotordynamics as well as their main numerical models and analysis methods for the vibration prediction. The mechanical and hydraulic excitations to the vibration are analyzed, and the pressure fluctuations induced by the unsteady turbulent flow is predicted in order to obtain the unsteady loads. This book also discusses the loads, constraint conditions and the elastic and damping characters of the mechanical system, the structure dynamic analysis, the rotor dynamic analysis and the system instability of hydraulic machines, including the illustration of monitoring system for the instability and the vibration in hydraulic units. All the problems are necessary for vibration pr...

  2. Handbook of hydraulic fluid technology

    CERN Document Server

    Totten, George E

    2011-01-01

    ""The Handbook of Hydraulic Fluid Technology"" serves as the foremost resource for designing hydraulic systems and for selecting hydraulic fluids used in engineering applications. Featuring new illustrations, data tables, as well as practical examples, this second edition is updated with essential information on the latest hydraulic fluids and testing methods. The detailed text facilitates unparalleled understanding of the total hydraulic system, including important hardware, fluid properties, and hydraulic lubricants. Written by worldwide experts, the book also offers a rigorous overview of h

  3. Design of a pressurized water loop heated by electric resistances

    International Nuclear Information System (INIS)

    Ribeiro, S.V.G.

    1981-01-01

    A pressurized water loop design is presented. Its operating pressure is 420 psi and we seek to simulate qualitatively some thermo-hydraulic phenomena of PWR reactors. The primary circuit simulator consists basically of two elements: 1)the test section housing 16 electric resistences dissipating a total power of 100 Kw; 2)the loop built of SCH40S 304L steel piping, consisting of the pump, a heat exchanger and the pressurizer. (Author) [pt

  4. Coherent-feedback-induced controllable optical bistability and photon blockade

    International Nuclear Information System (INIS)

    Liu, Yu-Long; Liu, Zhong-Peng; Zhang, Jing

    2015-01-01

    It is well known that some nonlinear phenomena such as strong photon blockade are difficult to observe in optomechanical systems with current experimental technology. Here we present a coherent feedback control strategy in which a linear cavity is coherently controlled by an optomechanical controller in a feedback manner. The coherent feedback loop transfers quantum nonlinearity from the controller to the controlled cavity causing destructive quantum interference to occur, and making it possible to observe strong nonlinear effects. With the help of the coherent feedback loop, large and tunable bistability and strong photon blockade of the cavity modes can be achieved even in the optomechanical weak coupling regime. Additionally, the coherent feedback loop leads to two-photon and multiphoton tunnelings for the controlled linear cavity, which are also typical quantum nonlinear phenomena. We hope that our work can give new perspectives on engineering nonlinear interactions in quantum systems. (paper)

  5. Experimental loop for SH2 (LECS)

    International Nuclear Information System (INIS)

    Strehar, N.R.; Bruzzoni, Pablo; Moras, J.J.; Cogozzo, E.O.

    1981-01-01

    An experimental loop is described for circulation of SH 2 that operates at 2 x 10 6 Pascal and 33 deg C. It was designed and constructed with the purpose of experimentally studying the hydraulic instability phenomenon that can be detected in cold isotopic exchange columns in the Girdler-Sulfide (GS) process of heavy water production. The main features of the different components of the loop are described, as well as the materials, the measurement and control instruments and the auxiliary equipment used, and finally the measuring methods to qualify and quantify the formation of froth. Furthermore, the loop's transportable metallic container is described, which allows to transport and connect it to CNEA's experimental heavy water plant or to any other heavy water plants using the GS method. Some tests made with inert gases that intended to verify the equipment's performance and to select the most adequate sieve trays for its operation are discussed. (M.E.L.) [es

  6. Description of the two-loop RELAP5 model of the L-Reactor at the Savannah River Site

    International Nuclear Information System (INIS)

    Cozzuol, J.M.; Davis, C.B.

    1989-12-01

    A two-loop RELAP5 input model of the L-Reactor at the Savannah River Site (SRS) was developed to support thermal-hydraulic analysis of SRS reactors. The model was developed to economically evaluate potential design changes. The primary simplifications in the model were in the number of loops and the detail in the moderator tank. The six loops in the reactor were modeled with two loops, one representing a single loop and the other representing five combined loops. The model has undergone a quality assurance review. This report describes the two-loop model, its limitations, and quality assurance. 29 refs., 18 figs., 10 tabs

  7. Loop Transfer Matrix and Loop Quantum Mechanics

    International Nuclear Information System (INIS)

    Savvidy, George K.

    2000-01-01

    The gonihedric model of random surfaces on a 3d Euclidean lattice has equivalent representation in terms of transfer matrix K(Q i ,Q f ), which describes the propagation of loops Q. We extend the previous construction of the loop transfer matrix to the case of nonzero self-intersection coupling constant κ. We introduce the loop generalization of Fourier transformation which allows to diagonalize transfer matrices, that depend on symmetric difference of loops only and express all eigenvalues of 3d loop transfer matrix through the correlation functions of the corresponding 2d statistical system. The loop Fourier transformation allows to carry out the analogy with quantum mechanics of point particles, to introduce conjugate loop momentum P and to define loop quantum mechanics. We also consider transfer matrix on 4d lattice which describes propagation of memebranes. This transfer matrix can also be diagonalized by using the generalized Fourier transformation, and all its eigenvalues are equal to the correlation functions of the corresponding 3d statistical system. In particular the free energy of the 4d membrane system is equal to the free energy of 3d gonihedric system of loops and is equal to the free energy of 2d Ising model. (author)

  8. Hydraulic Yaw System

    DEFF Research Database (Denmark)

    Stubkier, Søren; Pedersen, Henrik C.; Mørkholt, M.

    a hydraulic soft yaw system, which is able to reduce the loads on the wind turbine significantly. A full scale hydraulic yaw test rig is available for experiments and tests. The test rig is presented as well as the system schematics of the hydraulic yaw system....... the HAWC2 aeroelastic code and an extended model of the NREL 5MW turbine combined with a simplified linear model of the turbine, the parameters of the soft yaw system are optimized to reduce loading in critical components. Results shows that a significant reduction in fatigue and extreme loads to the yaw...... system and rotor shaft when utilizing the soft yaw drive concept compared to the original stiff yaw system. The physical demands of the hydraulic yaw system are furthermore examined for a life time of 20 years. Based on the extrapolated loads, the duty cycles show that it is possible to construct...

  9. Water Hydraulic Systems

    DEFF Research Database (Denmark)

    Conrad, Finn

    2005-01-01

    The paper presents research results using IT-Tools for CAD and dynamic modelling, simulation, analysis, and design of water hydraulic actuators for motion control of machines, lifts, cranes and robots. Matlab/Simulink and CATIA are used as IT-Tools. The contributions include results from on......-going research projects on fluid power and mechatronics based on tap water hydraulic servovalves and linear servo actuators and rotary vane actuators for motion control and power transmission. Development and design a novel water hydraulic rotary vane actuator for robot manipulators. Proposed mathematical...... modelling, control and simulation of a water hydraulic rotary vane actuator applied to power and control a two-links manipulator and evaluate performance. The results include engineering design and test of the proposed simulation models compared with IHA Tampere University’s presentation of research...

  10. Hydraulic hoisting and backfilling

    Science.gov (United States)

    Sauermann, H. B.

    In a country such as South Africa, with its large deep level mining industry, improvements in mining and hoisting techniques could result in substantial savings. Hoisting techniques, for example, may be improved by the introduction of hydraulic hoisting. The following are some of the advantages of hydraulic hoisting as against conventional skip hoisting: (1) smaller shafts are required because the pipes to hoist the same quantity of ore hydraulically require less space in the shaft than does skip hoisting equipment; (2) the hoisting capacity of a mine can easily be increased without the necessity of sinking new shafts. Large savings in capital costs can thus be made; (3) fully automatic control is possible with hydraulic hoisting and therefore less manpower is required; and (4) health and safety conditions will be improved.

  11. Feedback control of superconducting quantum circuits

    NARCIS (Netherlands)

    Ristè, D.

    2014-01-01

    Superconducting circuits have recently risen to the forefront of the solid-state prototypes for quantum computing. Reaching the stage of robust quantum computing requires closing the loop between measurement and control of quantum bits (qubits). This thesis presents the realization of feedback

  12. Theoretical Design of a Depolarized Interferometric Fiber-Optic Gyroscope (IFOG on SMF-28 Single-Mode Standard Optical Fiber Based on Closed-Loop Sinusoidal Phase Modulation with Serrodyne Feedback Phase Modulation Using Simulation Tools for Tactical and Industrial Grade Applications

    Directory of Open Access Journals (Sweden)

    Ramón José Pérez

    2016-04-01

    Full Text Available This article presents, by means of computational simulation tools, a full analysis and design of an Interferometric Fiber-Optic Gyroscope (IFOG prototype based on a closed-loop configuration with sinusoidal bias phase- modulation. The complete design of the different blocks, optical and electronic, is presented, including some novelties as the sinusoidal bias phase-modulation and the use of an integrator to generate the serrodyne phase-modulation signal. The paper includes detailed calculation of most parameter values, and the plots of the resulting signals obtained from simulation tools. The design is focused in the use of a standard single-mode optical fiber, allowing a cost competitive implementation compared to commercial IFOG, at the expense of reduced sensitivity. The design contains an IFOG model that accomplishes tactical and industrial grade applications (sensitivity ≤ 0.055 °/h. This design presents two important properties: (1 an optical subsystem with advanced conception: depolarization of the optical wave by means of Lyot depolarizers, which allows to use a sensing coil made by standard optical fiber, instead by polarization maintaining fiber, which supposes consequent cost savings and (2 a novel and simple electronic design that incorporates a linear analog integrator with reset in feedback chain, this integrator generating a serrodyne voltage-wave to apply to Phase-Modulator (PM, so that it will be obtained the interferometric phase cancellation. This particular feedback design with sawtooth-wave generated signal for a closed-loop configuration with sinusoidal bias phase modulation has not been reported till now in the scientific literature and supposes a considerable simplification with regard to previous designs based on similar configurations. The sensing coil consists of an 8 cm average diameter spool that contains 300 m of standard single-mode optical-fiber (SMF-28 type realized by quadrupolar winding. The working

  13. Theoretical Design of a Depolarized Interferometric Fiber-Optic Gyroscope (IFOG) on SMF-28 Single-Mode Standard Optical Fiber Based on Closed-Loop Sinusoidal Phase Modulation with Serrodyne Feedback Phase Modulation Using Simulation Tools for Tactical and Industrial Grade Applications.

    Science.gov (United States)

    Pérez, Ramón José; Álvarez, Ignacio; Enguita, José María

    2016-04-27

    This article presents, by means of computational simulation tools, a full analysis and design of an Interferometric Fiber-Optic Gyroscope (IFOG) prototype based on a closed-loop configuration with sinusoidal bias phase- modulation. The complete design of the different blocks, optical and electronic, is presented, including some novelties as the sinusoidal bias phase-modulation and the use of an integrator to generate the serrodyne phase-modulation signal. The paper includes detailed calculation of most parameter values, and the plots of the resulting signals obtained from simulation tools. The design is focused in the use of a standard single-mode optical fiber, allowing a cost competitive implementation compared to commercial IFOG, at the expense of reduced sensitivity. The design contains an IFOG model that accomplishes tactical and industrial grade applications (sensitivity ≤ 0.055 °/h). This design presents two important properties: (1) an optical subsystem with advanced conception: depolarization of the optical wave by means of Lyot depolarizers, which allows to use a sensing coil made by standard optical fiber, instead by polarization maintaining fiber, which supposes consequent cost savings and (2) a novel and simple electronic design that incorporates a linear analog integrator with reset in feedback chain, this integrator generating a serrodyne voltage-wave to apply to Phase-Modulator (PM), so that it will be obtained the interferometric phase cancellation. This particular feedback design with sawtooth-wave generated signal for a closed-loop configuration with sinusoidal bias phase modulation has not been reported till now in the scientific literature and supposes a considerable simplification with regard to previous designs based on similar configurations. The sensing coil consists of an 8 cm average diameter spool that contains 300 m of standard single-mode optical-fiber (SMF-28 type) realized by quadrupolar winding. The working wavelength will be

  14. Augmenting Environmental Interaction in Audio Feedback Systems

    Directory of Open Access Journals (Sweden)

    Seunghun Kim

    2016-04-01

    Full Text Available Audio feedback is defined as a positive feedback of acoustic signals where an audio input and output form a loop, and may be utilized artistically. This article presents new context-based controls over audio feedback, leading to the generation of desired sonic behaviors by enriching the influence of existing acoustic information such as room response and ambient noise. This ecological approach to audio feedback emphasizes mutual sonic interaction between signal processing and the acoustic environment. Mappings from analyses of the received signal to signal-processing parameters are designed to emphasize this specificity as an aesthetic goal. Our feedback system presents four types of mappings: approximate analyses of room reverberation to tempo-scale characteristics, ambient noise to amplitude and two different approximations of resonances to timbre. These mappings are validated computationally and evaluated experimentally in different acoustic conditions.

  15. The hydraulic wheel

    International Nuclear Information System (INIS)

    Alvarez Cardona, A.

    1985-01-01

    The present article this dedicated to recover a technology that key in disuse for the appearance of other techniques. It is the hydraulic wheel with their multiple possibilities to use their energy mechanical rotational in direct form or to generate electricity directly in the fields in the place and to avoid the high cost of transport and transformation. The basic theory is described that consists in: the power of the currents of water and the hydraulic receivers. The power of the currents is determined knowing the flow and east knowing the section of the flow and its speed; they are given you formulate to know these and direct mensuration methods by means of floodgates, drains and jumps of water. The hydraulic receivers or properly this hydraulic wheels that are the machines in those that the water acts like main force and they are designed to transmit the biggest proportion possible of absolute work of the water, the hydraulic wheels of horizontal axis are the common and they are divided in: you rotate with water for under, you rotate with side water and wheels with water for above. It is analyzed each one of them, their components are described; the conditions that should complete to produce a certain power and formulate them to calculate it. There are 25 descriptive figures of the different hydraulic wheels

  16. RF feedback simulation results for PEP-II

    International Nuclear Information System (INIS)

    Tighe, R.; Corredoura, P.

    1995-06-01

    A model of the RF feedback system for PEP-II has been developed to provide time-domain simulation and frequency-domain analysis of the complete system. The model includes the longitudinal beam dynamics, cavity fundamental resonance, feedback loops, and the nonlinear klystron operating near saturation. Transients from an ion clearing gap and a reference phase modulation from the longitudinal feedback system are also studied. Growth rates are predicted and overall system stability examined

  17. Control of conducting polymer actuators without physical feedback: simulated feedback control approach with particle swarm optimization

    International Nuclear Information System (INIS)

    Xiang, Xingcan; Mutlu, Rahim; Alici, Gursel; Li, Weihua

    2014-01-01

    Conducting polymer actuators have shown significant potential in articulating micro instruments, manipulation devices, and robotics. However, implementing a feedback control strategy to enhance their positioning ability and accuracy in any application requires a feedback sensor, which is extremely large in size compared to the size of the actuators. Therefore, this paper proposes a new sensorless control scheme without the use of a position feedback sensor. With the help of the system identification technique and particle swarm optimization, the control scheme, which we call the simulated feedback control system, showed a satisfactory command tracking performance for the conducting polymer actuator’s step and dynamic displacement responses, especially under a disturbance, without needing a physical feedback loop, but using a simulated feedback loop. The primary contribution of this study is to propose and experimentally evaluate the simulated feedback control scheme for a class of the conducting polymer actuators known as tri-layer polymer actuators, which can operate both in dry and wet media. This control approach can also be extended to other smart actuators or systems, for which the feedback control based on external sensing is impractical. (paper)

  18. The Brownian loop soup

    OpenAIRE

    Lawler, Gregory F.; Werner, Wendelin

    2003-01-01

    We define a natural conformally invariant measure on unrooted Brownian loops in the plane and study some of its properties. We relate this measure to a measure on loops rooted at a boundary point of a domain and show how this relation gives a way to ``chronologically add Brownian loops'' to simple curves in the plane.

  19. Grid-Current-Feedback Control for LCL-Filtered Grid Converters With Enhanced Stability

    DEFF Research Database (Denmark)

    Xin, Zhen; Wang, Xiongfei; Loh, Poh Chiang

    2017-01-01

    This paper proposes a Second-Order-Generalized- Integrator (SOGI)-based time delay compensation method for extending the stable region of dual-loop Grid-Current-Feedback (GCF) control system. According to the analysis, stable region of the dual-loop system should be designed below a certain...... critical frequency, before time delay compensation method can be applied. To always meet the requirement, relationship between single-loop converter-current-feedback and dual-loop GCF control is clarified, before a robust inner-loop gain for the dualloop GCF scheme is determined. Enforcing this gain allows...

  20. Adaptive Sliding Mode Control for Hydraulic Drives

    DEFF Research Database (Denmark)

    Schmidt, Lasse; Andersen, Torben Ole; Pedersen, Henrik C.

    2013-01-01

    This paper presents a new adaptive sliding mode controller generally applicable for position tracking control of electro-hydraulic valve-cylinder drives (VCD’s). The proposed control scheme requires limited knowledge on system parameters, and employs only piston- and valve spool position feedback...... employing parameter adaption through a recursive algorithm is presented. This is based on a reduced order model approximation of a VCD with unmatched valve flow- and cylinder asymmetries. Bounds on parameters are obtained despite lack of parameter knowledge, and the proposed controller demonstrates improved...

  1. Thermal-Hydraulic Tests for Reactor Core Safety

    International Nuclear Information System (INIS)

    Chun, Se Young; Chung, Moon Ki; Baek, Won Pil and others

    2005-04-01

    The reflood experiments for single rod annulus geometry have been performed to investigate the effect of spacer grid on thermal-hydraulics under reflood conditions. The reflood experimental loop for 6x6 rod bundle with a spacer grid developed in Korea has been provided. About 8000 data points for Post-CHF heat transfer have been obtained from the experiments About 1400 CHF data points for 3x3 Water and 5x5 Freon rod bundles have been obtained. The existing evaluation methodology for core safety under return-to-power conditions has been investigated using KAERI low flow CHF database. The hydraulic tests for turbulence mixing characteristics in subchannel of 5x5 rod bundle have been carried out using advanced measurement technique, LVD and the database for various spacer grids have been provided. In order to measure the turbulence mixing characteristics in details, the hydraulic loop with a magnified 5x5 rod bundle has been prepared. The database which was constructed through a systematic thermal hydraulic tests for the reflood phenomenon, CHF, Post-CHF is surely to be useful to the industry field, the regulation body and the development of thermal-hydraulic analysis code

  2. Computational advantages of reverberating loops for sensorimotor learning.

    Science.gov (United States)

    Fortney, Kristen; Tweed, Douglas B

    2012-03-01

    When we learn something new, our brain may store the information in synapses or in reverberating loops of electrical activity, but current theories of motor learning focus almost entirely on the synapses. Here we show that loops could also play a role and would bring advantages: loop-based algorithms can learn complex control tasks faster, with exponentially fewer neurons, and avoid the problem of weight transport. They do all this at a cost: in the presence of long feedback delays, loop algorithms cannot control very fast movements, but in this case, loop and synaptic mechanisms can complement each other-mixed systems quickly learn to make accurate but not very fast motions and then gradually speed up. Loop algorithms explain aspects of consolidation, the role of attention, and the relapses that are sometimes seen after a task has apparently been learned, and they make further predictions.

  3. Cavitation in Hydraulic Machinery

    Energy Technology Data Exchange (ETDEWEB)

    Kjeldsen, M.

    1996-11-01

    The main purpose of this doctoral thesis on cavitation in hydraulic machinery is to change focus towards the coupling of non-stationary flow phenomena and cavitation. It is argued that, in addition to turbulence, superimposed sound pressure fluctuations can have a major impact on cavitation and lead to particularly severe erosion. For the design of hydraulic devices this finding may indicate how to further limit the cavitation problems. Chapter 1 reviews cavitation in general in the context of hydraulic machinery, emphasizing the initial cavitation event and the role of the water quality. Chapter 2 discusses the existence of pressure fluctuations for situations common in such machinery. Chapter 3 on cavitation dynamics presents an algorithm for calculating the nucleation of a cavity cluster. Chapter 4 describes the equipment used in this work. 53 refs., 55 figs.,10 tabs.

  4. Automatic Loop Parallelization via Compiler Guided Refactoring

    DEFF Research Database (Denmark)

    Larsen, Per; Ladelsky, Razya; Lidman, Jacob

    For many parallel applications, performance relies not on instruction-level parallelism, but on loop-level parallelism. Unfortunately, many modern applications are written in ways that obstruct automatic loop parallelization. Since we cannot identify sufficient parallelization opportunities...... for these codes in a static, off-line compiler, we developed an interactive compilation feedback system that guides the programmer in iteratively modifying application source, thereby improving the compiler’s ability to generate loop-parallel code. We use this compilation system to modify two sequential...... benchmarks, finding that the code parallelized in this way runs up to 8.3 times faster on an octo-core Intel Xeon 5570 system and up to 12.5 times faster on a quad-core IBM POWER6 system. Benchmark performance varies significantly between the systems. This suggests that semi-automatic parallelization should...

  5. A Theory of Circular Organization and Negative Feedback: Defining Life in a Cybernetic Context

    Science.gov (United States)

    Tsokolov, Sergey

    2010-12-01

    All life today incorporates a variety of systems controlled by negative feedback loops and sometimes amplified by positive feedback loops. The first forms of life necessarily also required primitive versions of feedback, yet surprisingly little emphasis has been given to the question of how feedback emerged out of primarily chemical systems. One chemical system has been established that spontaneously develops autocatalytic feedback, the Belousov-Zhabotinsky (BZ) reaction. In this essay, I discuss the BZ reaction as a possible model for similar reactions that could have occurred under prebiotic Earth conditions. The main point is that the metabolism of contemporary life evolved from primitive homeostatic networks regulated by negative feedback. Because life could not exist in their absence, feedback loops should be included in definitions of life.

  6. Hydraulics and pneumatics

    CERN Document Server

    Parr, Andrew

    2006-01-01

    Nearly all industrial processes require objects to be moved, manipulated or subjected to some sort of force. This is frequently accomplished by means of electrical equipment (such as motors or solenoids), or via devices driven by air (pneumatics) or liquids (hydraulics).This book has been written by a process control engineer as a guide to the operation of hydraulic and pneumatic systems for all engineers and technicians who wish to have an insight into the components and operation of such a system.This second edition has been fully updated to include all recent developments su

  7. Closed loop identification of a piezoelectrically controlled radial gas bearing: Theory and experiment

    DEFF Research Database (Denmark)

    Sekunda, André Krabdrup; Niemann, Hans Henrik; Poulsen, Niels Kjølstad

    2018-01-01

    Gas bearing systems have extremely small damping properties. Feedback control is thus employed to increase the damping of gas bearings. Such a feedback loop correlates the input with the measurement noise which in turn makes the assumptions for direct identification invalid. The originality...... of this article lies in the investigation of the impact of using different identification methods to identify a rotor-bearing systems’ dynamic model when a feedback loop is active. Two different identification methods are employed. The first method is open loop Prediction Error Method, while the other method...

  8. Technology and control for hydraulic manipulators

    International Nuclear Information System (INIS)

    Measson, Y.; David, O.; Louveau, F.; Friconneau, J.P.

    2003-01-01

    Hydraulic manipulators are candidate for fusion reactor maintenance. Their main advantages are their large payload with respect to volume and mass, their reliability and their robustness. However, due to their force control limitations, they are disqualified for precise manipulation and are dangerous for the environment and themselves in case of unexpected collision. CEA, in collaboration with CYBERNETIX and IFREMER has developed the advanced hydraulic robot MAESTRO. Force and hybrid control has been developed in order to avoid the previous problems. Using 'pressure' control servo-valve instead of the standard 'flow' control servo-valve (standard configuration of the MAESTRO) makes a real simplification of the control loop. No more pressure sensors are needed for monitoring the hydraulic joint in force control mode and using this kind of valves makes big safety improvements. The French company IN-LHC, designed and manufactured a prototype of servo-valve that fits the performances and space constraints of the Maestro arm. A characterisation of this new product was made on a mock-up and a set of these prototypes integrated in the Maestro slave-arm. A comparison between the two actuating technologies was made and showed that the performances of the pressure servo-valves make it applicable to general application

  9. Hydraulic Arm Modeling via Matlab SimHydraulics

    Czech Academy of Sciences Publication Activity Database

    Věchet, Stanislav; Krejsa, Jiří

    2009-01-01

    Roč. 16, č. 4 (2009), s. 287-296 ISSN 1802-1484 Institutional research plan: CEZ:AV0Z20760514 Keywords : simulatin modeling * hydraulics * SimHydraulics Subject RIV: JD - Computer Applications, Robotics

  10. Combining experimental observations and modelling in investigating feedback and emotions in repeated selection tasks

    NARCIS (Netherlands)

    Fischer, A.R.H.; Blommaert, F.J.J.; Midden, C.J.H.

    2005-01-01

    People seem to learn tasks even without formal training. This can be modelled as the outcome of a feedback system that accumulates experience. In this paper we investigate such a feedback system, following an iterative research approach. A feedback loop is specified that is detailed using

  11. Combining experimental observation and modelling in investigating feedback and emotions in repeated selection tasks

    NARCIS (Netherlands)

    Fischer, A.R.H.; Blommaert, F.J.J.; Midden, C.J.H.

    2005-01-01

    People seem to learn tasks even without formal training. This can be modelled as the outcome of a feedback system that accumulates experience. In this paper we investigate such a feedback system, following an iterative research approach. A feedback loop is specified that is detailed using

  12. Generalized modal analysis for closed-loop piezoelectric devices

    International Nuclear Information System (INIS)

    Giraud-Audine, Christophe; Giraud, Frédéric; Amberg, Michel; Lemaire-Semail, Betty

    2015-01-01

    Stress in a piezoelectric material can be controlled by imposing an electrical field. Thanks to feedback, this electrical field can be a function of some strain-related measurement so as to confer on the piezoelectric device a closed-loop macroscopic behaviour. In this paper we address the modelling of such a system by extending the modal decomposition methods to account for the closed loop. To do so, the boundary conditions are modified to include the electrical feedback circuit, hence allowing a closed-loop modal analysis. A case study is used to illustrate the theory and to validate it. The main advantage of the method is that design issues such as the coupling factor of the device and closed-loop stability are simultaneously captured. (paper)

  13. Renormalization of loop functions for all loops

    International Nuclear Information System (INIS)

    Brandt, R.A.; Neri, F.; Sato, M.

    1981-01-01

    It is shown that the vacuum expectation values W(C 1 ,xxx, C/sub n/) of products of the traces of the path-ordered phase factors P exp[igcontour-integral/sub C/iA/sub μ/(x)dx/sup μ/] are multiplicatively renormalizable in all orders of perturbation theory. Here A/sub μ/(x) are the vector gauge field matrices in the non-Abelian gauge theory with gauge group U(N) or SU(N), and C/sub i/ are loops (closed paths). When the loops are smooth (i.e., differentiable) and simple (i.e., non-self-intersecting), it has been shown that the generally divergent loop functions W become finite functions W when expressed in terms of the renormalized coupling constant and multiplied by the factors e/sup -K/L(C/sub i/), where K is linearly divergent and L(C/sub i/) is the length of C/sub i/. It is proved here that the loop functions remain multiplicatively renormalizable even if the curves have any finite number of cusps (points of nondifferentiability) or cross points (points of self-intersection). If C/sub γ/ is a loop which is smooth and simple except for a single cusp of angle γ, then W/sub R/(C/sub γ/) = Z(γ)W(C/sub γ/) is finite for a suitable renormalization factor Z(γ) which depends on γ but on no other characteristic of C/sub γ/. This statement is made precise by introducing a regularization, or via a loop-integrand subtraction scheme specified by a normalization condition W/sub R/(C-bar/sub γ/) = 1 for an arbitrary but fixed loop C-bar/sub γ/. Next, if C/sub β/ is a loop which is smooth and simple except for a cross point of angles β, then W(C/sub β/) must be renormalized together with the loop functions of associated sets S/sup i//sub β/ = ]C/sup i/ 1 ,xxx, C/sup i//sub p/i] (i = 2,xxx,I) of loops C/sup i//sub q/ which coincide with certain parts of C/sub β/equivalentC 1 1 . Then W/sub R/(S/sup i//sub β/) = Z/sup i/j(β)W(S/sup j//sub β/) is finite for a suitable matrix Z/sup i/j

  14. Mine drivage in hydraulic mines

    Energy Technology Data Exchange (ETDEWEB)

    Ehkber, B Ya

    1983-09-01

    From 20 to 25% of labor cost in hydraulic coal mines falls on mine drivage. Range of mine drivage is high due to the large number of shortwalls mined by hydraulic monitors. Reducing mining cost in hydraulic mines depends on lowering drivage cost by use of new drivage systems or by increasing efficiency of drivage systems used at present. The following drivage methods used in hydraulic mines are compared: heading machines with hydraulic haulage of cut rocks and coal, hydraulic monitors with hydraulic haulage, drilling and blasting with hydraulic haulage of blasted rocks. Mining and geologic conditions which influence selection of the optimum mine drivage system are analyzed. Standardized cross sections of mine roadways driven by the 3 methods are shown in schemes. Support systems used in mine roadways are compared: timber supports, roof bolts, roof bolts with steel elements, and roadways driven in rocks without a support system. Heading machines (K-56MG, GPKG, 4PU, PK-3M) and hydraulic monitors (GMDTs-3M, 12GD-2) used for mine drivage are described. Data on mine drivage in hydraulic coal mines in the Kuzbass are discussed. From 40 to 46% of roadways are driven by heading machines with hydraulic haulage and from 12 to 15% by hydraulic monitors with hydraulic haulage.

  15. Closed orbit feedback with digital signal processing

    International Nuclear Information System (INIS)

    Chung, Y.; Kirchman, J.; Lenkszus, F.

    1994-01-01

    The closed orbit feedback experiment conducted on the SPEAR using the singular value decomposition (SVD) technique and digital signal processing (DSP) is presented. The beam response matrix, defined as beam motion at beam position monitor (BPM) locations per unit kick by corrector magnets, was measured and then analyzed using SVD. Ten BPMs, sixteen correctors, and the eight largest SVD eigenvalues were used for closed orbit correction. The maximum sampling frequency for the closed loop feedback was measured at 37 Hz. Using the proportional and integral (PI) control algorithm with the gains Kp = 3 and K I = 0.05 and the open-loop bandwidth corresponding to 1% of the sampling frequency, a correction bandwidth (-3 dB) of approximately 0.8 Hz was achieved. Time domain measurements showed that the response time of the closed loop feedback system for 1/e decay was approximately 0.25 second. This result implies ∼ 100 Hz correction bandwidth for the planned beam position feedback system for the Advanced Photon Source storage ring with the projected 4-kHz sampling frequency

  16. Hydraulic shock absorbers

    International Nuclear Information System (INIS)

    Thatcher, G.; Davidson, D. F.

    1984-01-01

    A hydraulic shock absorber of the dash pot kind for use with electrically conducting liquid such as sodium, has magnet means for electro magnetically braking a stream of liquid discharged from the cylinder. The shock absorber finds use in a liquid metal cooled nuclear reactor for arresting control rods

  17. Preparation of hydraulic cement

    Energy Technology Data Exchange (ETDEWEB)

    1921-08-28

    A process for the preparation of hydraulic cement by the use of oil-shale residues is characterized in that the oil-shale refuse is mixed with granular basic blast-furnace slag and a small amount of portland cement and ground together.

  18. Small hydraulic turbine drives

    Science.gov (United States)

    Rostafinski, W. A.

    1970-01-01

    Turbine, driven by the fluid being pumped, requires no external controls, is completely integrated into the flow system, and has bearings which utilize the main fluid for lubrication and cooling. Torque capabilities compare favorably with those developed by positive displacement hydraulic motors.

  19. Modelling of Hydraulic Robot

    DEFF Research Database (Denmark)

    Madsen, Henrik; Zhou, Jianjun; Hansen, Lars Henrik

    1997-01-01

    This paper describes a case study of identifying the physical model (or the grey box model) of a hydraulic test robot. The obtained model is intended to provide a basis for model-based control of the robot. The physical model is formulated in continuous time and is derived by application...

  20. Manual Hydraulic Structures

    NARCIS (Netherlands)

    Molenaar, W.F.; Voorendt, M.Z.

    This manual is the result of group work and origins in Dutch lecture notes that have been used since long time. Amongst the employees of the Hydraulic Engineering Department that contributed to this work are dr.ir. S. van Baars, ir.K.G.Bezuijen, ir.G.P.Bourguignon, prof.ir.A.Glerum,

  1. Water Treatment Technology - Hydraulics.

    Science.gov (United States)

    Ross-Harrington, Melinda; Kincaid, G. David

    One of twelve water treatment technology units, this student manual on hydraulics provides instructional materials for three competencies. (The twelve units are designed for a continuing education training course for public water supply operators.) The competencies focus on the following areas: head loss in pipes in series, function loss in…

  2. Feedback and Incentives

    DEFF Research Database (Denmark)

    Eriksson, Tor Viking; Poulsen, Anders; Villeval, Marie Claire

    2009-01-01

    This paper experimentally investigates the impact of different pay schemes and relative performance feedback policies on employee effort. We explore three feedback rules: no feedback on relative performance, feedback given halfway through the production period, and continuously updated feedback. ...... behind, and front runners do not slack off. But in both pay schemes relative performance feedback reduces the quality of the low performers' work; we refer to this as a "negative quality peer effect"....

  3. Cradle modification for hydraulic ram

    International Nuclear Information System (INIS)

    Koons, B.M.

    1995-01-01

    The analysis of the cradle hydraulic system considers stress, weld strength, and hydraulic forces required to lift and support the cradle/pump assembly. The stress and weld strength of the cradle modifications is evaluated to ensure that they meet the requirements of the American Institute for Steel Construction (AISC 1989). The hydraulic forces are evaluated to ensure that the hydraulic system is capable of rotating the cradle and pump assembly to the vertical position (between 70 degrees and 90 degrees)

  4. Study on the application of energy storage system in offshore wind turbine with hydraulic transmission

    International Nuclear Information System (INIS)

    Fan, Yajun; Mu, Anle; Ma, Tao

    2016-01-01

    Highlights: • Hydraulic offshore wind turbine is capable of outputting near constant power. • Open loop hydraulic transmission uses seawater as the working fluid. • Linear control strategy distributes total flow according to demand and supply. • Constant pressure hydraulic accumulator stores/releases the surplus energy. • Simulations show the dynamic performance of the hybrid system. - Abstract: A novel offshore wind turbine comprising fluid power transmission and energy storage system is proposed. In this wind turbine, the conventional mechanical transmission is replaced by an open-loop hydraulic system, in which seawater is sucked through a variable displacement pump in nacelle connected directly with the rotor and utilized to drive a Pelton turbine installed on the floating platform. Aiming to smooth and stabilize the output power, an energy storage system with the capability of flexible charging and discharging is applied. The related mathematical model is developed, which contains some sub-models that are categorized as the wind turbine rotor, hydraulic pump, transmission pipeline, proportional valve, accumulator and hydraulic turbine. A linear control strategy is adopted to distribute the flow out of the proportional valve through comparing the demand power with captured wind energy by hydraulic pump. Ultimately, two time domain simulations demonstrate the operation of the hybrid system when the hydraulic accumulator is utilized and show how this system can be used for load leveling and stabilizing the output power.

  5. Hydraulic turbines and auxiliary equipment

    Energy Technology Data Exchange (ETDEWEB)

    Luo Gaorong [Organization of the United Nations, Beijing (China). International Centre of Small Hydroelectric Power Plants

    1995-07-01

    This document presents a general overview on hydraulic turbines and auxiliary equipment, emphasizing the turbine classification, in accordance with the different types of turbines, standard turbine series in China, turbine selection based on the basic data required for the preliminary design, general hill model curves, chart of turbine series and the arrangement of application for hydraulic turbines, hydraulic turbine testing, and speed regulating device.

  6. An optimal open/closed-loop control method with application to a pre-stressed thin duralumin plate

    Science.gov (United States)

    Nadimpalli, Sruthi Raju

    The excessive vibrations of a pre-stressed duralumin plate, suppressed by a combination of open-loop and closed-loop controls, also known as open/closed-loop control, is studied in this thesis. The two primary steps involved in this process are: Step (I) with an assumption that the closed-loop control law is proportional, obtain the optimal open-loop control by direct minimization of the performance measure consisting of energy at terminal time and a penalty on open-loop control force via calculus of variations. If the performance measure also involves a penalty on closed-loop control effort then a Fourier based method is utilized. Step (II) the energy at terminal time is minimized numerically to obtain optimal values of feedback gains. The optimal closed-loop control gains obtained are used to describe the displacement and the velocity of open-loop, closed-loop and open/closed-loop controlled duralumin plate.

  7. Hydraulic Hybrid Vehicle Publications | Transportation Research | NREL

    Science.gov (United States)

    Hydraulic Hybrid Vehicle Publications Hydraulic Hybrid Vehicle Publications The following technical papers and fact sheets provide information about NREL's hydraulic hybrid fleet vehicle evaluations . Refuse Trucks Project Startup: Evaluating the Performance of Hydraulic Hybrid Refuse Vehicles. Bob

  8. Random walk loop soup

    OpenAIRE

    Lawler, Gregory F.; Ferreras, José A. Trujillo

    2004-01-01

    The Brownian loop soup introduced in Lawler and Werner (2004) is a Poissonian realization from a sigma-finite measure on unrooted loops. This measure satisfies both conformal invariance and a restriction property. In this paper, we define a random walk loop soup and show that it converges to the Brownian loop soup. In fact, we give a strong approximation result making use of the strong approximation result of Koml\\'os, Major, and Tusn\\'ady. To make the paper self-contained, we include a proof...

  9. Thermal Hydraulic Integral Effect Tests for Pressurized Water Reactors

    International Nuclear Information System (INIS)

    Baek, Won Pil; Song, C. H.; Kim, Y. S.

    2007-02-01

    The objectives of the project are to construct a thermal-hydraulic integral effect test facility and to perform the tests for design, operation, and safety regulation of pressurized water reactors. In the first phase of this project (1997.8∼2002.3), the basic technology for thermal-hydraulic integral effect tests was established and the basic design of the test facility was accomplished. In the second phase (2002.4∼2005.2), an optimized design of the ATLAS (Advanced Thermal-hydraulic Test Loop for Accident Simulation) was established and the construction of the facility was almost completed. In the third phase (2005.3∼2007.2), the construction and commission tests of the ATLAS are to be completed and some first-phase tests are to be conducted

  10. On loop extensions and cohomology of loops

    OpenAIRE

    Benítez, Rolando Jiménez; Meléndez, Quitzeh Morales

    2015-01-01

    In this paper are defined cohomology-like groups that classify loop extensions satisfying a given identity in three variables for association identities, and in two variables for the case of commutativity. It is considered a large amount of identities. This groups generalize those defined in works of Nishigori [2] and of Jhonson and Leedham-Green [4]. It is computed the number of metacyclic extensions for trivial action of the quotient on the kernel in one particular case for left Bol loops a...

  11. Neutron transport in irradiation loops (IRENE loop)

    International Nuclear Information System (INIS)

    Sarsam, Maher.

    1980-09-01

    This thesis is composed of two parts with different aspects. Part one is a technical description of the loop and its main ancillary facilities as well as of the safety and operational regulations. The measurement methods on the model of the ISIS reactor and on the loop in the OSIRIS reactor are described. Part two deals with the possibility of calculating the powers dissipated by each rod of the fuel cluster, using appropriate computer codes, not only in the reflector but also in the core and to suggest a method of calculation [fr

  12. A Quasi-Type-1 Phase-Locked Loop Structure

    DEFF Research Database (Denmark)

    Golestan, Saeed; Fernandez, Francisco Daniel Freijedo; Vidal, Ana

    2014-01-01

    The grid voltage phase and frequency are crucial information in control of most grid connected power electronic based equipment. Most often, a phase-locked loop (PLL) is employed for this purpose. A PLL is a closed-loop feedback control system that the phase of its output signal is related...... to the phase of its input signal. Arguably, the simplest PLL is a type-1 PLL. The type-1 PLLs are characterized by having only one integrator in their control loop and therefore having a high stability margin. However, they suffer from a serious drawback: they cannot achieve zero average steady-state phase...

  13. Development and Applications of a General Coupled Thermal-hydraulic/Neutronic Model for the Ringhals-3 Pressurized Water Reactor

    International Nuclear Information System (INIS)

    Staalek, Mathias

    2008-03-01

    Coupled calculations are important for the simulation of nuclear power plants when there is a strong feedback between the neutron kinetics and the thermal-hydraulics. A general coupled model of the Ringhals-3 Pressurized Water Reactor has been developed for this purpose. The development is outlined in the thesis with details given in the appended papers. A PARCS model was developed for the core calculations and a RELAP5 model for the thermal-hydraulic calculations. The RELAP5 model has 157 channels for modelling the flow in the fuel assemblies. This means that there is a one-one correspondence radially between the neutronic and thermal-hydraulic nodalization. This detailed mapping between the neutron kinetics and the thermal-hydraulics makes it possible to use the model for all kinds of transient. To provide realistic material data to the PARCS model, a cross-section interface was developed. With this interface one can import material data from a binary CASMO-4 library file into PARCS. Due to the one-to-one mapping, any any core loading can easily be considered. The PARCS model was benchmarked against measurements of the steady-state power distribution of Ringhals-3. The power shape was well reproduced by the model. Validational work for steady-state conditions of the thermal-hydraulic was also successfully performed. The most challenging part of the validation of a coupled model is for transients. This is much more difficult since the dynamics of the system becomes very important. Two transients that occurred at Ringhals-3 were chosen for the validational work. The first transient was a Load Rejection Transient. In general the model gave good results but some problems were experienced, e.g. the pressurizer pressure turned out to be more difficult to be correctly simulated. The second transient was a Loss of Feed Water transient. A malfunctioning feed water control valve closed, and therefore shut down the feed water supply to the steam generator in one of the

  14. Development and Applications of a General Coupled Thermal-hydraulic/Neutronic Model for the Ringhals-3 Pressurized Water Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Staalek, Mathias

    2008-03-15

    Coupled calculations are important for the simulation of nuclear power plants when there is a strong feedback between the neutron kinetics and the thermal-hydraulics. A general coupled model of the Ringhals-3 Pressurized Water Reactor has been developed for this purpose. The development is outlined in the thesis with details given in the appended papers. A PARCS model was developed for the core calculations and a RELAP5 model for the thermal-hydraulic calculations. The RELAP5 model has 157 channels for modelling the flow in the fuel assemblies. This means that there is a one-one correspondence radially between the neutronic and thermal-hydraulic nodalization. This detailed mapping between the neutron kinetics and the thermal-hydraulics makes it possible to use the model for all kinds of transient. To provide realistic material data to the PARCS model, a cross-section interface was developed. With this interface one can import material data from a binary CASMO-4 library file into PARCS. Due to the one-to-one mapping, any any core loading can easily be considered. The PARCS model was benchmarked against measurements of the steady-state power distribution of Ringhals-3. The power shape was well reproduced by the model. Validational work for steady-state conditions of the thermal-hydraulic was also successfully performed. The most challenging part of the validation of a coupled model is for transients. This is much more difficult since the dynamics of the system becomes very important. Two transients that occurred at Ringhals-3 were chosen for the validational work. The first transient was a Load Rejection Transient. In general the model gave good results but some problems were experienced, e.g. the pressurizer pressure turned out to be more difficult to be correctly simulated. The second transient was a Loss of Feed Water transient. A malfunctioning feed water control valve closed, and therefore shut down the feed water supply to the steam generator in one of the

  15. The development of radiation hardened robot for nuclear facility - Development of embedded controller for hydraulic robot

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byung Kook; Kim, Jae Kwon [Korea Advanced Institute of Science and Technology, Taejon (Korea)

    2000-04-01

    We designed and implemented a reliable hierarchical control system for hydraulic robots for nuclear power plant maintenance. In hazardous environments such as nuclear power plants, robot systems or automated equipment should be used instead of human being for maintenance and repair. Such robot should guarantee high reliability in hazardous environments such as high radiation or high temperature. The overall system is composed of three hierarchical subsystems: i) supervisory controller in safe zone for operator interaction with monitoring and commanding and graphic user interface, ii) master controller in semi-hazardous zone for control function, and iii) slave controller in hazardous zone for sensing and actuation. These subsystems are connected with suitable communication channels: a) master-slave communication channel implemented with CAN (Control Area Network) and b) supervisory-master communication with Ethernet. The master and the slave controllers construct a feedback closed-loop control system. In order to improve reliability, the slave controller is duplicated using cold-standby scheme, and master-slave communication channel is also duplicated. The overall system is implemented harmonically, and we obtained fast control interval of 1msec, which is sufficient for high-performance real-time control. 12 refs., 58 figs., 13 tabs. (Author)

  16. Feedback stabilization of electrostatic reactive instabilities

    International Nuclear Information System (INIS)

    Richards, R.K.

    1976-01-01

    A general theory for the feedback stabilization of electrostatic reactive instabilities is developed which includes the effects of dissipation in the plasma and frequency dependence in the sensor-suppressor elements and in the external feedback circuit. This theory is compared to experiments involving particular reactive instability, an interchange mode, found in a magnetic mirror device; these results are found to be in good agreement with theory. One noteworthy result is that a frequency dependence in the overall gain and phase shift of the feedback loop can cause destabilization at large gain. Multimode feedback stabilization is studied using the spatial variation of two interchange modes to separate them such that each can be acted upon individually by the feedback system. The transfer function of the plasma is also examined. This analysis is used for mode identification and location of the pole positions. As an example of using feedback as a diagnostic tool, instability induced transport is studied. Here feedback is used to control the amplitude of fluctuations at saturation

  17. Hydraulic Limits on Maximum Plant Transpiration

    Science.gov (United States)

    Manzoni, S.; Vico, G.; Katul, G. G.; Palmroth, S.; Jackson, R. B.; Porporato, A. M.

    2011-12-01

    Photosynthesis occurs at the expense of water losses through transpiration. As a consequence of this basic carbon-water interaction at the leaf level, plant growth and ecosystem carbon exchanges are tightly coupled to transpiration. In this contribution, the hydraulic constraints that limit transpiration rates under well-watered conditions are examined across plant functional types and climates. The potential water flow through plants is proportional to both xylem hydraulic conductivity (which depends on plant carbon economy) and the difference in water potential between the soil and the atmosphere (the driving force that pulls water from the soil). Differently from previous works, we study how this potential flux changes with the amplitude of the driving force (i.e., we focus on xylem properties and not on stomatal regulation). Xylem hydraulic conductivity decreases as the driving force increases due to cavitation of the tissues. As a result of this negative feedback, more negative leaf (and xylem) water potentials would provide a stronger driving force for water transport, while at the same time limiting xylem hydraulic conductivity due to cavitation. Here, the leaf water potential value that allows an optimum balance between driving force and xylem conductivity is quantified, thus defining the maximum transpiration rate that can be sustained by the soil-to-leaf hydraulic system. To apply the proposed framework at the global scale, a novel database of xylem conductivity and cavitation vulnerability across plant types and biomes is developed. Conductivity and water potential at 50% cavitation are shown to be complementary (in particular between angiosperms and conifers), suggesting a tradeoff between transport efficiency and hydraulic safety. Plants from warmer and drier biomes tend to achieve larger maximum transpiration than plants growing in environments with lower atmospheric water demand. The predicted maximum transpiration and the corresponding leaf water

  18. Controllable recirculators with charged capacitors in a feedback loop

    International Nuclear Information System (INIS)

    Malevich, I.A.; Postoyanov, Yu.I.; Efremenko, D.A.

    1975-01-01

    Devices for generating stable pulse trains in the 100 nsec-10 μsec range and trains of paired pulses with a controllable generation period are described. The parameters of the long-term generation-frequency stability and the probability density of short fluctuations of the period were investigated

  19. The Asian economy: trade structure interpreted by feedback loop analysis

    OpenAIRE

    Sonis, Michael; Guilhoto, Joaquim José Martins; Hewings, Geoffrey J.D.

    1995-01-01

    The recent discussions that focused on the problems of the Uruguay Round of the General Agreement on Tariffs and Trade [GATT] together with the emergence of strengthened and expanded free trade areas [such as NAFTA, European Union and MERCOSUL/MERCOSUR] have created the need for careful analysis of the nature of internal and external dependence among nations and, within any nation, among the constituent regions. The picture that is obtained from inspection of import and export flows is only ...

  20. Feedback amplification loop drives malignant growth in epithelial tissues.

    Science.gov (United States)

    Muzzopappa, Mariana; Murcia, Lada; Milán, Marco

    2017-08-29

    Interactions between cells bearing oncogenic mutations and the surrounding microenvironment, and cooperation between clonally distinct cell populations, can contribute to the growth and malignancy of epithelial tumors. The genetic techniques available in Drosophila have contributed to identify important roles of the TNF-α ligand Eiger and mitogenic molecules in mediating these interactions during the early steps of tumor formation. Here we unravel the existence of a tumor-intrinsic-and microenvironment-independent-self-reinforcement mechanism that drives tumor initiation and growth in an Eiger-independent manner. This mechanism relies on cell interactions between two functionally distinct cell populations, and we present evidence that these cell populations are not necessarily genetically different. Tumor-specific and cell-autonomous activation of the tumorigenic JNK stress-activated pathway drives the expression of secreted signaling molecules and growth factors to delaminating cells, which nonautonomously promote proliferative growth of the partially transformed epithelial tissue. We present evidence that cross-feeding interactions between delaminating and nondelaminating cells increase each other's sizes and that these interactions can explain the unlimited growth potential of these tumors. Our results will open avenues toward our molecular understanding of those social cell interactions with a relevant function in tumor initiation in humans.

  1. Extracellular matrix proteins: a positive feedback loop in lung fibrosis?

    NARCIS (Netherlands)

    Blaauboer, M.E.; van Boeijen, F.R.; Emson, C.L.; Turner, S.M.; Zandieh-Doulabi, B.; Hanemaaijer, R.; Smit, T.H.; Stoop, R.; Everts, V.

    2014-01-01

    Lung fibrosis is characterized by excessive deposition of extracellular matrix. This not only affects tissue architecture and function, but it also influences fibroblast behavior and thus disease progression. Here we describe the expression of elastin, type V collagen and tenascin C during the

  2. Extracellular matrix proteins: A positive feedback loop in lung fibrosis?

    NARCIS (Netherlands)

    Blaauboer, M.E.; Boeijen, F.R.; Emson, C.L.; Turner, S.M.; Zandieh-Doulabi, B.; Hanemaaijer, R.; Smit, T.H.; Stoop, R.; Everts, V.

    2014-01-01

    Lung fibrosis is characterized by excessive deposition of extracellular matrix. This not only affects tissue architecture and function, but it also influences fibroblast behavior and thus disease progression. Here we describe the expression of elastin, type V collagen and tenascin C during the

  3. Finding the positive feedback loops underlying multi-stationarity

    DEFF Research Database (Denmark)

    Feliu, Elisenda; Wiuf, Carsten

    2015-01-01

    demonstrate the procedure by applying it to several examples of signaling processes, including a ubiquitination and an apoptosis network, and to models extracted from the Biomodels database. The procedure is implemented in Maple. CONCLUSIONS: We have developed and implemented an automated procedure to find...

  4. Toponym Extraction and Disambiguation Enhancement Using Loops of Feedback

    NARCIS (Netherlands)

    Habib, Mena Badieh; van Keulen, Maurice; Fred, A.; Dietz, J.L.G.; Liu, K.; Filipe, J.

    2013-01-01

    Toponym extraction and disambiguation have received much attention in recent years. Typical fields addressing these topics are information retrieval, natural language processing, and semantic web. This paper addresses two problems with toponym extraction and disambiguation. First, almost no existing

  5. A Feedback Loop Model of Postmerger Performance: Customers and Competitors.

    Science.gov (United States)

    Bastien, David T.

    1994-01-01

    Offers a case study of a merger of two local theaters. Finds that organizational change causes customers to change vendors; the announcement of a merger fuels efforts by competitors to "steal" market share; and organizational change leads to more organizational change. (SR)

  6. Hydraulic manipulator research at ORNL

    International Nuclear Information System (INIS)

    Kress, R.L.; Jansen, J.F.; Love, L.J.

    1997-01-01

    Recently, task requirements have dictated that manipulator payload capacity increase to accommodate greater payloads, greater manipulator length, and larger environmental interaction forces. General tasks such as waste storage tank cleanup and facility dismantlement and decommissioning require manipulator life capacities in the range of hundreds of pounds rather than tens of pounds. To meet the increased payload capacities demanded by present-day tasks, manipulator designers have turned once again to hydraulics as a means of actuation. In order to successfully design, build, and deploy a new hydraulic manipulator (or subsystem), sophisticated modeling, analysis, and control experiments are usually needed. Oak Ridge National Laboratory (ORNL) has a history of projects that incorporate hydraulics technology, including mobile robots, teleoperated manipulators, and full-scale construction equipment. In addition, to support the development and deployment of new hydraulic manipulators, ORNL has outfitted a significant experimental laboratory and has developed the software capability for research into hydraulic manipulators, hydraulic actuators, hydraulic systems, modeling of hydraulic systems, and hydraulic controls. The purpose of this article is to describe the past hydraulic manipulator developments and current hydraulic manipulator research capabilities at ORNL. Included are example experimental results from ORNL's flexible/prismatic test stand

  7. Hydraulic manipulator research at ORNL

    Energy Technology Data Exchange (ETDEWEB)

    Kress, R.L.; Jansen, J.F. [Oak Ridge National Lab., TN (United States); Love, L.J. [Oak Ridge Inst. for Science and Education, TN (United States)

    1997-03-01

    Recently, task requirements have dictated that manipulator payload capacity increase to accommodate greater payloads, greater manipulator length, and larger environmental interaction forces. General tasks such as waste storage tank cleanup and facility dismantlement and decommissioning require manipulator life capacities in the range of hundreds of pounds rather than tens of pounds. To meet the increased payload capacities demanded by present-day tasks, manipulator designers have turned once again to hydraulics as a means of actuation. In order to successfully design, build, and deploy a new hydraulic manipulator (or subsystem), sophisticated modeling, analysis, and control experiments are usually needed. Oak Ridge National Laboratory (ORNL) has a history of projects that incorporate hydraulics technology, including mobile robots, teleoperated manipulators, and full-scale construction equipment. In addition, to support the development and deployment of new hydraulic manipulators, ORNL has outfitted a significant experimental laboratory and has developed the software capability for research into hydraulic manipulators, hydraulic actuators, hydraulic systems, modeling of hydraulic systems, and hydraulic controls. The purpose of this article is to describe the past hydraulic manipulator developments and current hydraulic manipulator research capabilities at ORNL. Included are example experimental results from ORNL`s flexible/prismatic test stand.

  8. Skriftlig feedback i engelskundervisningen

    DEFF Research Database (Denmark)

    Kjærgaard, Hanne Wacher

    2017-01-01

    The article describes useful feedback strategies in language teaching and describes the feedback practices of lower-seconday teachers in Denmark. The article is aimed at language teahcers in secondary schools.......The article describes useful feedback strategies in language teaching and describes the feedback practices of lower-seconday teachers in Denmark. The article is aimed at language teahcers in secondary schools....

  9. Student Engagement with Feedback

    Science.gov (United States)

    Scott, Jon; Shields, Cathy; Gardner, James; Hancock, Alysoun; Nutt, Alex

    2011-01-01

    This report considers Biological Sciences students' perceptions of feedback, compared with those of the University as a whole, this includes what forms of feedback were considered most useful and how feedback used. Compared with data from previous studies, Biological Sciences students gave much greater recognition to oral feedback, placing it on a…

  10. Mechanics of Hydraulic Fractures

    Science.gov (United States)

    Detournay, Emmanuel

    2016-01-01

    Hydraulic fractures represent a particular class of tensile fractures that propagate in solid media under pre-existing compressive stresses as a result of internal pressurization by an injected viscous fluid. The main application of engineered hydraulic fractures is the stimulation of oil and gas wells to increase production. Several physical processes affect the propagation of these fractures, including the flow of viscous fluid, creation of solid surfaces, and leak-off of fracturing fluid. The interplay and the competition between these processes lead to multiple length scales and timescales in the system, which reveal the shifting influence of the far-field stress, viscous dissipation, fracture energy, and leak-off as the fracture propagates.

  11. Hydraulically actuated artificial muscles

    Science.gov (United States)

    Meller, M. A.; Tiwari, R.; Wajcs, K. B.; Moses, C.; Reveles, I.; Garcia, E.

    2012-04-01

    Hydraulic Artificial Muscles (HAMs) consisting of a polymer tube constrained by a nylon mesh are presented in this paper. Despite the actuation mechanism being similar to its popular counterpart, which are pneumatically actuated (PAM), HAMs have not been studied in depth. HAMs offer the advantage of compliance, large force to weight ratio, low maintenance, and low cost over traditional hydraulic cylinders. Muscle characterization for isometric and isobaric tests are discussed and compared to PAMs. A model incorporating the effect of mesh angle and friction have also been developed. In addition, differential swelling of the muscle on actuation has also been included in the model. An application of lab fabricated HAMs for a meso-scale robotic system is also presented.

  12. Water loop for training

    International Nuclear Information System (INIS)

    Moeller, S.V.

    1983-02-01

    The procedures used to operate the water loop of the Institute of Nuclear Enginering (IEN) in Brazil are presented. The aim is to help future operators of the training water loop in the operation technique and in a better comprehension of the phenomena occured during the execution of an experience. (E.G.) [pt

  13. Undular Hydraulic Jump

    Directory of Open Access Journals (Sweden)

    Oscar Castro-Orgaz

    2015-04-01

    Full Text Available The transition from subcritical to supercritical flow when the inflow Froude number Fo is close to unity appears in the form of steady state waves called undular hydraulic jump. The characterization of the undular hydraulic jump is complex due to the existence of a non-hydrostatic pressure distribution that invalidates the gradually-varied flow theory, and supercritical shock waves. The objective of this work is to present a mathematical model for the undular hydraulic jump obtained from an approximate integration of the Reynolds equations for turbulent flow assuming that the Reynolds number R is high. Simple analytical solutions are presented to reveal the physics of the theory, and a numerical model is used to integrate the complete equations. The limit of application of the theory is discussed using a wave breaking condition for the inception of a surface roller. The validity of the mathematical predictions is critically assessed using physical data, thereby revealing aspects on which more research is needed

  14. A hydraulic hybrid propulsion method for automobiles with self-adaptive system

    International Nuclear Information System (INIS)

    Wu, Wei; Hu, Jibin; Yuan, Shihua; Di, Chongfeng

    2016-01-01

    A hydraulic hybrid vehicle with the self-adaptive system is proposed. The mode-switching between the driving mode and the hydraulic regenerative braking mode is realised by the pressure cross-feedback control. Extensive simulated and tested results are presented. The control parameters are reduced and the energy efficiency can be increased by the self-adaptive system. The mode-switching response is fast. The response time can be adjusted by changing the controlling spool diameter of the hydraulic operated check valve in the self-adaptive system. The closing of the valve becomes faster with a smaller controlling spool diameter. The hydraulic regenerative braking mode can be achieved by changing the hydraulic transformer controlled angle. Compared with the convention electric-hydraulic system, the self-adaptive system for the hydraulic hybrid vehicle mode-switching has a higher reliability and a lower cost. The efficiency of the hydraulic regenerative braking is also increased. - Highlights: • A new hybrid system with a self-adaptive system for automobiles is presented. • The mode-switching is realised by the pressure cross-feedback control. • The energy efficiency can be increased with the self-adaptive system. • The control parameters are reduced with the self-adaptive system.

  15. Design and Implementation of Output Feedback Control for Piezo Actuated Structure Using Embedded System

    Directory of Open Access Journals (Sweden)

    R.Maheswari

    2008-06-01

    Full Text Available This paper presents the design of periodic output feedback control using state feedback gain to control the vibration of piezo actuated cantilever beam. The effectiveness of the controller is evaluated through simulation and experimentally by exciting the structure at resonance. Real time implementation of the controller is done using microcontroller. The closed loop eigen values of the system with periodic output feedback and state feedback are identical.

  16. Pressure control of hydraulic servo system using proportional control valve

    International Nuclear Information System (INIS)

    Yang, Kyong Uk; Oh, In Ho; Lee, Ill Yeong

    1999-01-01

    The purpose of this study is to develop a control scheme for the hydraulic servo system which can rapidly control the pressure in a hydraulic cylinder with very short stroke. Compared with the negligible stroke of the cylinder in the system, the flow gain of the proportional pressure control valve constituting the hydraulic servo system is relatively large and the time delay on the response of the valve is quite long. Therefore, the pressure control system, in this study tends to get unstable during operations. Considering the above mentioned characteristics of the system, a two-degree-of-freedom control scheme, composed of the I-PDD 2 ... feedback compensator and the feedforward controller, is proposed. The reference model scheme is used in deciding the parameters of the controllers. The validity of the proposed control scheme is confirmed through the experiments

  17. Tutorial on beam-based feedback systems for linacs

    International Nuclear Information System (INIS)

    Hendrickson, L.; Allison, S.; Gromme, T.; Grossberg, P.; Himel, T.; Krauter, K.; MacKenzie, R.; Ross, M.; Sass, R.; Shoaee, H.

    1994-08-01

    A generalized fast feedback system stabilizes beams in the SLC. It performs measurements and modifies actuator settings to control beam states such as position, angle, energy and intensity on a pulse to pulse basis. An adaptive cascade feature allows communication between a series of linac loops, avoiding overcorrection problems. The system is based on the state space formalism of digital control theory. Due to the database-driven design, new loops are added without requiring software modifications. Recent enhancements support the monitoring and control of nonlinear states such as beam phase using excitation techniques. In over three years of operation, the feedback system has grown from its original eight loops to more than fifty loops, and it has been invaluable in stabilizing the machine

  18. Closed-Loop Tension Control System for Injection Moulding Machine

    African Journals Online (AJOL)

    When the mould unit is full, this drive keeps transporting filament materials without proper control. This project developed a closed loop feedback tension control system and it is to replace servo motor drive system for the transportation of filament and it demonstrated a new technological advancement and the theory of ...

  19. Estimation of Parametric Fault in Closed-loop Systems

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik; Poulsen, Niels Kjølstad

    2015-01-01

    The aim of this paper is to present a method for estimation of parametric faults in closed-loop systems. The key technology applied in this paper is coprime factorization of both the dynamic system as well as the feedback controller. Using the Youla-Jabr-Bongiorno-Kucera (YJBK) parameterization...

  20. Thermal Hydraulic Integral Effect Tests for Pressurized Water Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Baek, W. P.; Song, C. H.; Kim, Y. S. and others

    2005-02-15

    The objectives of the project are to construct a thermal-hydraulic integral effect test facility and to perform various integral effect tests for design, operation, and safety regulation of pressurized water reactors. During the first phase of this project (1997.8{approx}2002.3), the basic technology for thermal-hydraulic integral effect tests was established and the basic design of the test facility was accomplished: a full-height, 1/300-volume-scaled full pressure facility for APR1400, an evolutionary pressurized water reactor that was developed by Korean industry. Main objectives of the present phase (2002.4{approx}2005.2), was to optimize the facility design and to construct the experimental facility. We have performed following researches: 1) Optimization of the basic design of the thermal-hydraulic integral effect test facility for PWRs - ATLAS (Advanced Thermal-hydraulic Test Loop for Accident Simulation) - Reduced height design for APR1400 (+ specific design features of KSNP safety injection systems) - Thermal-hydraulic scaling based on three-level scaling methodology by Ishii et al. 2) Construction of the ATLAS facility - Detailed design of the test facility - Manufacturing and procurement of components - Installation of the facility 3) Development of supporting technology for integral effect tests - Development and application of advanced instrumentation technology - Preliminary analysis of test scenarios - Development of experimental procedures - Establishment and implementation of QA system/procedure.

  1. Hydraulic System Design of Hydraulic Actuators for Large Butterfly Valves

    Directory of Open Access Journals (Sweden)

    Ye HUANG

    2014-09-01

    Full Text Available Hydraulic control systems of butterfly valves are presently valve-controlled and pump-controlled. Valve-controlled hydraulic systems have serious power loss and generate much heat during throttling. Pump-controlled hydraulic systems have no overflow or throttling losses but are limited in the speed adjustment of the variable-displacement pump, generate much noise, pollute the environment, and have motor power that does not match load requirements, resulting in low efficiency under light loads and wearing of the variable-displacement pump. To overcome these shortcomings, this article designs a closed hydraulic control system in which an AC servo motor drives a quantitative pump that controls a spiral swinging hydraulic cylinder, and analyzes and calculates the structure and parameters of a spiral swinging hydraulic cylinder. The hydraulic system adjusts the servo motor’s speed according to the requirements of the control system, and the motor power matches the power provided to components, thus eliminating the throttling loss of hydraulic circuits. The system is compact, produces a large output force, provides stable transmission, has a quick response, and is suitable as a hydraulic control system of a large butterfly valve.

  2. Large lithium loop experience

    International Nuclear Information System (INIS)

    Kolowith, R.; Owen, T.J.; Berg, J.D.; Atwood, J.M.

    1981-10-01

    An engineering design and operating experience of a large, isothermal, lithium-coolant test loop are presented. This liquid metal coolant loop is called the Experimental Lithium System (ELS) and has operated safely and reliably for over 6500 hours through September 1981. The loop is used for full-scale testing of components for the Fusion Materials Irradiation Test (FMIT) Facility. Main system parameters include coolant temperatures to 430 0 C and flow to 0.038 m 3 /s (600 gal/min). Performance of the main pump, vacuum system, and control system is discussed. Unique test capabilities of the ELS are also discussed

  3. Flow characteristics of natural circulation in a lead-bismuth eutectic loop

    Institute of Scientific and Technical Information of China (English)

    Chen-Chong Yue; Liu-Li Chen; Ke-Feng Lyu; Yang Li; Sheng Gao; Yue-Jing Liu; Qun-Ying Huang

    2017-01-01

    Lead and lead-alloys are proposed in future advanced nuclear system as coolant and spallation target.To test the natural circulation and gas-lift and obtain thermal-hydraulics data for computational fluid dynamics (CFD) and system code validation,a lead-bismuth eutectic rectangular loop,the KYLIN-Ⅱ Thermal Hydraulic natural circulation test loop,has been designed and constructed by the FDS team.In this paper,theoretical analysis on natural circulation thermal-hydraulic performance is described and the steady-state natural circulation experiment is performed.The results indicated that the natural circulation capability depends on the loop resistance and the temperature and center height differences between the hot and cold legs.The theoretical analysis results agree well with,while the CFD deviate from,the experimental results.

  4. Adaptive Sliding Mode Control of Dynamic Systems Using Double Loop Recurrent Neural Network Structure.

    Science.gov (United States)

    Fei, Juntao; Lu, Cheng

    2018-04-01

    In this paper, an adaptive sliding mode control system using a double loop recurrent neural network (DLRNN) structure is proposed for a class of nonlinear dynamic systems. A new three-layer RNN is proposed to approximate unknown dynamics with two different kinds of feedback loops where the firing weights and output signal calculated in the last step are stored and used as the feedback signals in each feedback loop. Since the new structure has combined the advantages of internal feedback NN and external feedback NN, it can acquire the internal state information while the output signal is also captured, thus the new designed DLRNN can achieve better approximation performance compared with the regular NNs without feedback loops or the regular RNNs with a single feedback loop. The new proposed DLRNN structure is employed in an equivalent controller to approximate the unknown nonlinear system dynamics, and the parameters of the DLRNN are updated online by adaptive laws to get favorable approximation performance. To investigate the effectiveness of the proposed controller, the designed adaptive sliding mode controller with the DLRNN is applied to a -axis microelectromechanical system gyroscope to control the vibrating dynamics of the proof mass. Simulation results demonstrate that the proposed methodology can achieve good tracking property, and the comparisons of the approximation performance between radial basis function NN, RNN, and DLRNN show that the DLRNN can accurately estimate the unknown dynamics with a fast speed while the internal states of DLRNN are more stable.

  5. Inner Current Loop Analysis and Design Based on Resonant Regulators for Isolated Microgrids

    DEFF Research Database (Denmark)

    Federico, de Bosio; de Sousa Ribeiro, Luiz Antonio; Soares Lima, Marcel

    2015-01-01

    Inner current and voltage loops are fundamental in achieving good performance of microgrids based on power electronics voltage source inverters. The analysis and design of these loops are essential for the adequate operation of these systems. This paper investigates the effect of state feedback...

  6. Feedbacks in human-landscape systems

    Science.gov (United States)

    Chin, Anne

    2015-04-01

    As human interactions with Earth systems intensify in the "Anthropocene", understanding the complex relationships among human activity, landscape change, and societal responses to those changes is increasingly important. Interdisciplinary research centered on the theme of "feedbacks" in human-landscape systems serves as a promising focus for unraveling these interactions. Deciphering interacting human-landscape feedbacks extends our traditional approach of considering humans as unidirectional drivers of change. Enormous challenges exist, however, in quantifying impact-feedback loops in landscapes with significant human alterations. This paper illustrates an example of human-landscape interactions following a wildfire in Colorado (USA) that elicited feedback responses. After the 2012 Waldo Canyon Fire, concerns for heightened flood potential and debris flows associated with post-fire hydrologic changes prompted local landowners to construct tall fences at the base of a burned watershed. These actions changed the sediment transport regime and promoted further landscape change and human responses in a positive feedback cycle. The interactions ultimately increase flood and sediment hazards, rather than dampening the effects of fire. A simple agent-based model, capable of integrating social and hydro-geomorphological data, demonstrates how such interacting impacts and feedbacks could be simulated. Challenges for fully capturing human-landscape feedback interactions include the identification of diffuse and subtle feedbacks at a range of scales, the availability of data linking impact with response, the identification of multiple thresholds that trigger feedback mechanisms, and the varied metrics and data needed to represent both the physical and human systems. By collaborating with social scientists with expertise in the human causes of landscape change, as well as the human responses to those changes, geoscientists could more fully recognize and anticipate the coupled

  7. Natively unstructured loops differ from other loops.

    Directory of Open Access Journals (Sweden)

    Avner Schlessinger

    2007-07-01

    Full Text Available Natively unstructured or disordered protein regions may increase the functional complexity of an organism; they are particularly abundant in eukaryotes and often evade structure determination. Many computational methods predict unstructured regions by training on outliers in otherwise well-ordered structures. Here, we introduce an approach that uses a neural network in a very different and novel way. We hypothesize that very long contiguous segments with nonregular secondary structure (NORS regions differ significantly from regular, well-structured loops, and that a method detecting such features could predict natively unstructured regions. Training our new method, NORSnet, on predicted information rather than on experimental data yielded three major advantages: it removed the overlap between testing and training, it systematically covered entire proteomes, and it explicitly focused on one particular aspect of unstructured regions with a simple structural interpretation, namely that they are loops. Our hypothesis was correct: well-structured and unstructured loops differ so substantially that NORSnet succeeded in their distinction. Benchmarks on previously used and new experimental data of unstructured regions revealed that NORSnet performed very well. Although it was not the best single prediction method, NORSnet was sufficiently accurate to flag unstructured regions in proteins that were previously not annotated. In one application, NORSnet revealed previously undetected unstructured regions in putative targets for structural genomics and may thereby contribute to increasing structural coverage of large eukaryotic families. NORSnet found unstructured regions more often in domain boundaries than expected at random. In another application, we estimated that 50%-70% of all worm proteins observed to have more than seven protein-protein interaction partners have unstructured regions. The comparative analysis between NORSnet and DISOPRED2 suggested

  8. Introduction to Loop Heat Pipes

    Science.gov (United States)

    Ku, Jentung

    2015-01-01

    This is the presentation file for the short course Introduction to Loop Heat Pipes, to be conducted at the 2015 Thermal Fluids and Analysis Workshop, August 3-7, 2015, Silver Spring, Maryland. This course will discuss operating principles and performance characteristics of a loop heat pipe. Topics include: 1) pressure profiles in the loop; 2) loop operating temperature; 3) operating temperature control; 4) loop startup; 4) loop shutdown; 5) loop transient behaviors; 6) sizing of loop components and determination of fluid inventory; 7) analytical modeling; 8) examples of flight applications; and 9) recent LHP developments.

  9. Modeling and simulation of Indus-2 RF feedback control system

    International Nuclear Information System (INIS)

    Sharma, D.; Bagduwal, P.S.; Tiwari, N.; Lad, M.; Hannurkar, P.R.

    2012-01-01

    Indus-2 synchrotron radiation source has four RF stations along with their feedback control systems. For higher beam energy and current operation amplitude and phase feedback control systems of Indus-2 are being upgraded. To understand the behaviour of amplitude and phase control loop under different operating conditions, modelling and simulation of RF feedback control system is done. RF cavity baseband I/Q model has been created due to its close correspondence with actual implementation and better computational efficiency which makes the simulation faster. Correspondence between cavity baseband and RF model is confirmed by comparing their simulation results. Low Level RF (LLRF) feedback control system simulation is done using the same cavity baseband I/Q model. Error signals are intentionally generated and response of the closed loop system is observed. Simulation will help us in optimizing parameters of upgraded LLRF system for higher beam energy and current operation. (author)

  10. Hydraulic nuts (HydraNuts) for reactor vessel tensioning

    International Nuclear Information System (INIS)

    Greenwell, Steve

    2008-01-01

    The paper will present how the introduction of hydraulic nuts - HydraNuts, has reduced critical path times, dose exposure for workers and improved working safety conditions around the reactor vessel during tensioning or de-tensioning operations. It will focus upon detailing the advantages realized by utilities that have introduced the technology and providing examples of the improvements made to the process as well as discussing the engineering design change packages required to make the conversion to the new system. HydraNuts replace the traditional mechanical nut/stud tensioning equipment, combining the two functions into a single system, designed for easy installation and operation by one individual. The primary components of the HydraNut can be assembled without the need for external crane or hoist support and are designed so that each sub assembly can be fitted separately. Once all HydraNuts are fitted to the Rx vessel studs and are sitting on the main Rx vessel head flange, then a system of flexible hydraulic hoses is connected to them, forming a closed loop hydraulic harness, which will allow for simultaneous pressurization of all HydraNuts. Hydraulic pressure is obtained by the use of a hydraulic pumping unit and the resultant load generated in each HydraNut is transferred to the stud and main flange closure is obtained. While maintaining hydraulic pressure, a locking ring is rotated into place on the HydraNut assembly that will support the tensioned load mechanically when the hydraulic pressure is released from the hose harness assembly. The hose harness is removed and the HydraNut is now functioning as a mechanical nut retaining the tensioned load. The HydraNut system for Rx vessel applications was first introduced into a plant in the U.S. in October 2006 and based upon the benefits realized subsequent projects are under way within the Asian and U.S. operating fleet. (author)

  11. Feedback on Feedback--Does It Work?

    Science.gov (United States)

    Speicher, Oranna; Stollhans, Sascha

    2015-01-01

    It is well documented that providing assessment feedback through the medium of screencasts is favourably received by students and encourages deeper engagement with the feedback given by the language teacher (inter alia Abdous & Yoshimura, 2010; Brick & Holmes, 2008; Cann, 2007; Stannard, 2007). In this short paper we will report the…

  12. Error analysis of acceleration control loops of a synchrotron

    International Nuclear Information System (INIS)

    Zhang, S.Y.; Weng, W.T.

    1991-01-01

    For beam control during acceleration, it is conventional to derive the frequency from an external reference, be it a field marker or an external oscillator, to provide phase and radius feedback loops to ensure the phase stability, radial position and emittance integrity of the beam. The open and closed loop behaviors of both feedback control and their response under the possible frequency, phase and radius errors are derived from fundamental principles and equations. The stability of the loops is investigated under a wide range of variations of the gain and time delays. Actual system performance of the AGS Booster is analyzed and compared to commissioning experiences. Such analysis is useful for setting design criteria and tolerances for new proton synchrotrons. 4 refs., 13 figs

  13. Diffusion of Wilson loops

    International Nuclear Information System (INIS)

    Brzoska, A.M.; Lenz, F.; Thies, M.; Negele, J.W.

    2005-01-01

    A phenomenological analysis of the distribution of Wilson loops in SU(2) Yang-Mills theory is presented in which Wilson loop distributions are described as the result of a diffusion process on the group manifold. It is shown that, in the absence of forces, diffusion implies Casimir scaling and, conversely, exact Casimir scaling implies free diffusion. Screening processes occur if diffusion takes place in a potential. The crucial distinction between screening of fundamental and adjoint loops is formulated as a symmetry property related to the center symmetry of the underlying gauge theory. The results are expressed in terms of an effective Wilson loop action and compared with various limits of SU(2) Yang-Mills theory

  14. Blind loop syndrome

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/001146.htm Blind loop syndrome To use the sharing features on ... Clinical Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David ...

  15. Mashup the OODA Loop

    National Research Council Canada - National Science Library

    Heier, Jeffrey E

    2008-01-01

    ...) processes via the Observe, Orient, Decide, and Act (OODA) Loop concept. As defined by Wikipedia, a mashup is a Website or application that combines the content from more than one source into an integrated presentation...

  16. Operation of the PEP transverse beam feedback

    International Nuclear Information System (INIS)

    Olson, C.W.; Paterson, J.M.; Pellegrin, J.L.; Rees, J.R.

    1981-02-01

    The PEP Storage Ring has been equipped with a wide band beam feedback system capable of damping the vertical and horizontal motion of six bunches. The oscillation detection is done at a symmetry point on the Storage Ring and feedback is applied at the same location one orbital period later. The signal is synchronously gated and the system appears as twelve independent feedback loops, operating on the two coordinates of each of the six bunches. Two beam deflection electrodes are driven each by a low-Q push-pull amplifier which is tuned at the 72nd harmonic of the revolution frequency and suppressed-carrier modulation is generated by a sequence of the detected bunch oscillations. The design parameters are reviewed as well as the salient features of the hardware, and the impact of this system on the machine operation is evaluated in the light of experimental results

  17. Hydraulic Stability of Accropode Armour

    DEFF Research Database (Denmark)

    Jensen, T.; Burcharth, H. F.; Frigaard, Peter

    The present report describes the hydraulic model tests of Accropode armour layers carried out at the Hydraulics Laboratory at Aalborg University from November 1995 through March 1996. The objective of the model tests was to investigate the hydraulic stability of Accropode armour layers...... with permeable core (crushed granite with a gradation of 5-8 mm). The outcome of this study is described in "Hydraulic Stability of Single-Layer Dolos and Accropode Armour Layers" by Christensen & Burcharth (1995). In January/February 1996, Research Assistant Thomas Jensen carried out a similar study...

  18. Particle tracking code of simulating global RF feedback

    International Nuclear Information System (INIS)

    Mestha, L.K.

    1991-09-01

    It is well known in the ''control community'' that a good feedback controller design is deeply rooted in the physics of the system. For example, when accelerating the beam we must keep several parameters under control so that the beam travels within the confined space. Important parameters include the frequency and phase of the rf signal, the dipole field, and the cavity voltage. Because errors in these parameters will progressively mislead the beam from its projected path in the tube, feedback loops are used to correct the behavior. Since the feedback loop feeds energy to the system, it changes the overall behavior of the system and may drive it to instability. Various types of controllers are used to stabilize the feedback loop. Integrating the beam physics with the feedback controllers allows us to carefully analyze the beam behavior. This will not only guarantee optimal performance but will also significantly enhance the ability of the beam control engineer to deal effectively with the interaction of various feedback loops. Motivated by this theme, we developed a simple one-particle tracking code to simulate particle behavior with feedback controllers. In order to achieve our fundamental objective, we can ask some key questions: What are the input and output parameters? How can they be applied to the practical machine? How can one interface the rf system dynamics such as the transfer characteristics of the rf cavities and phasing between the cavities? Answers to these questions can be found by considering a simple case of a single cavity with one particle, tracking it turn-by-turn with appropriate initial conditions, then introducing constraints on crucial parameters. Critical parameters are rf frequency, phase, and amplitude once the dipole field has been given. These are arranged in the tracking code so that we can interface the feedback system controlling them

  19. RF feedback simulation for the PEP-II B Factory

    International Nuclear Information System (INIS)

    Tighe, R.

    1994-06-01

    A model, of the beam and RF system for PEP-11 has been developed to allow both time-domain simulation and frequency-domain analysis of the complete system. The model includes the full set of feedback loops and nonlinear elements such as the beam and klystron. The model may be used to predict beam and feedback stability in the presence of nonlinearities through time-domain simulation as well as system frequency response about a given operating point

  20. Reactor loops at Chalk River

    International Nuclear Information System (INIS)

    Sochaski, R.O.

    1962-07-01

    This report describes broadly the nine in-reactor loops, and their components, located in and around the NRX and NRU reactors at Chalk River. First an introduction and general description is given of the loops and their function, supplemented with a table outlining some loop specifications and nine simplified flow sheets, one for each individual loop. The report then proceeds to classify each loop into two categories, the 'main loop circuit' and the 'auxiliary circuit', and descriptions are given of each circuit's components in turn. These components, in part, are comprised of the main loop pumps, the test section, loop heaters, loop coolers, delayed-neutron monitors, surge tank, Dowtherm coolers, loop piping. Here again photographs, drawings and tables are included to provide a clearer understanding of the descriptive literature and to include, in tables, some specifications of the more important components in each loop. (author)

  1. Quantum feedback for rapid state preparation in the presence of control imperfections

    International Nuclear Information System (INIS)

    Combes, Joshua; Wiseman, Howard M

    2011-01-01

    Quantum feedback control protocols can improve the operation of quantum devices. Here we examine the performance of a purification protocol when there are imperfections in the controls. The ideal feedback protocol produces an x-eigenstate from a mixed state in the minimum time, and is known as rapid state preparation. The imperfections we examine include time delays in the feedback loop, finite strength feedback, calibration errors and inefficient detection. We analyse these imperfections using the Wiseman-Milburn feedback master equation and related formalism. We find that the protocol is most sensitive to time delays in the feedback loop. For systems with slow dynamics, however, our analysis suggests that inefficient detection would be the bigger problem. We also show how system imperfections, such as dephasing and damping, can be included in a model via the feedback master equation.

  2. Dechanneling by dislocation loops

    International Nuclear Information System (INIS)

    Chalant, Gerard.

    1976-09-01

    Ion implantation always induces the creation of dislocation loops. When the damage profile is determined by a backscattering technique, the dechanneling by these loops is implicitely at the origin of these measurements. The dechanneling of alpha particles by dislocation loops produced by the coalescence of quenched-in vacancies in aluminium is studied. The dechanneling and the concentration of loops were determined simultaneously. The dechanneling width around dislocation was found equal to lambda=6A, both for perfect and imperfect loops having a mean diameter d=250A. In the latter case, a dechanneling probability chi=0.34 was determined for the stacking fault, in good agreement with previous determination in gold. A general formula is proposed which takes into account the variation of lambda with the curvature (or the diameter d) of the loops. Finally, by a series of isothermal anneals, the self-diffusion energy ΔH of aluminium was measured. The value obtained ΔH=1.32+-0.10eV is in good agreement with the values obtained by other methods [fr

  3. Precision Force Control for an Electro-Hydraulic Press Machine

    Directory of Open Access Journals (Sweden)

    Hong-Ming Chen

    2014-08-01

    Full Text Available This thesis is primarily intended to design a PC-based control system to control the force of an electro-hydraulic servo press system for implementing precision force control. The main feature is to develop a composite control by using the relief valve and the flow servo valve. Using feedback from a force sensor, a fuzzy controller was designed with LabVIEW software as the system control core for achieving a precision force control for the hydraulic cylinder on its travel and output. The weakness of hydraulic systems is that hydraulic oil is compressible and prone to leaking, and its characteristics can vary with oil temperature, thus making it difficult for a general linear controller to achieve accurate control. Therefore, a fuzzy controller was designed with LabVIEW along with a NI-PCI_6221 interface card and a load cell to control the servo valve flow and the relief valve to control the pressure source. The testing results indicate that accurate force control output of an electro-hydraulic servo press system can be obtained.

  4. Control-structure interaction in precision pointing servo loops

    Science.gov (United States)

    Spanos, John T.

    1989-01-01

    The control-structure interaction problem is addressed via stability analysis of a generic linear servo loop model. With the plant described by the rigid body mode and a single elastic mode, structural flexibility is categorized into one of three types: (1) appendage, (2) in-the-loop minimum phase, and (3) in-the-loop nonminimum phase. Closing the loop with proportional-derivative (PD) control action and introducing sensor roll-off dynamics in the feedback path, stability conditions are obtained. Trade studies are conducted with modal frequency, modal participation, modal damping, loop bandwidth, and sensor bandwidth treated as free parameters. Results indicate that appendage modes are most likely to produce instability if they are near the sensor rolloff, whereas in-the-loop modes are most dangerous near the loop bandwidth. The main goal of this paper is to provide a fundamental understanding of the control-structure interaction problem so that it may benefit the design of complex spacecraft and pointing system servo loops. In this framework, the JPL Pathfinder gimbal pointer is considered as an example.

  5. Feedback Augmented Sub-Ranging (FASR) Quantizer

    Science.gov (United States)

    Guilligan, Gerard

    2012-01-01

    This innovation is intended to reduce the size, power, and complexity of pipeline analog-to-digital converters (ADCs) that require high resolution and speed along with low power. Digitizers are important components in any application where analog signals (such as light, sound, temperature, etc.) need to be digitally processed. The innovation implements amplification of a sampled residual voltage in a switched capacitor amplifier stage that does not depend on charge redistribution. The result is less sensitive to capacitor mismatches that cause gain errors, which are the main limitation of such amplifiers in pipeline ADCs. The residual errors due to mismatch are reduced by at least a factor of 16, which is equivalent to at least 4 bits of improvement. The settling time is also faster because of a higher feedback factor. In traditional switched capacitor residue amplifiers, closed-loop amplification of a sampled and held residue signal is achieved by redistributing sampled charge onto a feedback capacitor around a high-gain transconductance amplifier. The residual charge that was sampled during the acquisition or sampling phase is stored on two or more capacitors, often equal in value or integral multiples of each other. During the hold or amplification phase, all of the charge is redistributed onto one capacitor in the feedback loop of the amplifier to produce an amplified voltage. The key error source is the non-ideal ratios of feedback and input capacitors caused by manufacturing tolerances, called mismatches. The mismatches cause non-ideal closed-loop gain, leading to higher differential non-linearity. Traditional solutions to the mismatch errors are to use larger capacitor values (than dictated by thermal noise requirements) and/or complex calibration schemes, both of which increase the die size and power dissipation. The key features of this innovation are (1) the elimination of the need for charge redistribution to achieve an accurate closed-loop gain of two

  6. Hydraulic fracturing proppants

    Directory of Open Access Journals (Sweden)

    V. P. P. de Campos

    Full Text Available Abstract Hydrocarbon reservoirs can be classified as unconventional or conventional depending on the oil and gas extraction difficulty, such as the need for high-cost technology and techniques. The hydrocarbon extraction from bituminous shale, commonly known as shale gas/oil, is performed by using the hydraulic fracturing technique in unconventional reservoirs where 95% water, 0.5% of additives and 4.5% of proppants are used. Environmental problems related to hydraulic fracturing technique and better performance/development of proppants are the current challenge faced by companies, researchers, regulatory agencies, environmentalists, governments and society. Shale gas is expected to increase USA fuel production, which triggers the development of new proppants and technologies of exploration. This paper presents a review of the definition of proppants, their types, characteristics and situation in the world market and information about manufacturers. The production of nanoscale materials such as anticorrosive and intelligent proppants besides proppants with carbon nanotubes is already carried out on a scale of tonnes per year in Belgium, Germany and Asia countries.

  7. Hydraulic jett mixing

    International Nuclear Information System (INIS)

    Ackerman, J.R.

    1989-01-01

    Efficient mixing of reactants into a waste stream has always been a problem in that there has been no mixer capable of combining all the elements of enhanced mixing into a single piece of equipment. Through the development of a mixing system for the mining industry to treat acid mine water containing heavy metals, a versatile new hydraulic jetting static mixer has been developed that has no moving parts and a clean bore with no internal components. This paper reports that the main goal of the development of the hydraulic jett mixer was to reduce the size of the tankage required for an acid mine drainage (AMD) treatment plant through development of a static mixing device that could coincidentally aerate the treatment flow. This process equipment being developed would simultaneously adjust the pH and oxidize the metals allowing formation of the hydroxide sludges required for sedimentation and removal of the metals from the treatment stream. In effect, the device eliminates two reaction tanks, the neutralization/mixing tank and the aeration tank

  8. Applied hydraulic transients

    CERN Document Server

    Chaudhry, M Hanif

    2014-01-01

    This book covers hydraulic transients in a comprehensive and systematic manner from introduction to advanced level and presents various methods of analysis for computer solution. The field of application of the book is very broad and diverse and covers areas such as hydroelectric projects, pumped storage schemes, water-supply systems, cooling-water systems, oil pipelines and industrial piping systems. Strong emphasis is given to practical applications, including several case studies, problems of applied nature, and design criteria. This will help design engineers and introduce students to real-life projects. This book also: ·         Presents modern methods of analysis suitable for computer analysis, such as the method of characteristics, explicit and implicit finite-difference methods and matrix methods ·         Includes case studies of actual projects ·         Provides extensive and complete treatment of governed hydraulic turbines ·         Presents design charts, desi...

  9. Robust Hinfinity position control synthesis of an electro-hydraulic servo system.

    Science.gov (United States)

    Milić, Vladimir; Situm, Zeljko; Essert, Mario

    2010-10-01

    This paper focuses on the use of the techniques based on linear matrix inequalities for robust H(infinity) position control synthesis of an electro-hydraulic servo system. A nonlinear dynamic model of the hydraulic cylindrical actuator with a proportional valve has been developed. For the purpose of the feedback control an uncertain linearized mathematical model of the system has been derived. The structured (parametric) perturbations in the electro-hydraulic coefficients are taken into account. H(infinity) controller extended with an integral action is proposed. To estimate internal states of the electro-hydraulic servo system an observer is designed. Developed control algorithms have been tested experimentally in the laboratory model of an electro-hydraulic servo system. Copyright © 2010 ISA. Published by Elsevier Ltd. All rights reserved.

  10. Rateless feedback codes

    DEFF Research Database (Denmark)

    Sørensen, Jesper Hemming; Koike-Akino, Toshiaki; Orlik, Philip

    2012-01-01

    This paper proposes a concept called rateless feedback coding. We redesign the existing LT and Raptor codes, by introducing new degree distributions for the case when a few feedback opportunities are available. We show that incorporating feedback to LT codes can significantly decrease both...... the coding overhead and the encoding/decoding complexity. Moreover, we show that, at the price of a slight increase in the coding overhead, linear complexity is achieved with Raptor feedback coding....

  11. Improving Convergence of Iterative Feedback Tuning using Optimal External Perturbations

    DEFF Research Database (Denmark)

    Huusom, Jakob Kjøbsted; Hjalmarsson, Håkon; Poulsen, Niels Kjølstad

    2008-01-01

    Iterative feedback tuning constitutes an attractive control loop tuning method for processes in the absence of sufficient process insight. It is a purely data driven approach to optimization of the loop performance. The standard formulation ensures an unbiased estimate of the loop performance cost...... function gradient, which is used in a search algorithm. A slow rate of convergence of the tuning method is often experienced when tuning for disturbance rejection. This is due to a poor signal to noise ratio in the process data. A method is proposed for increasing the information content in data...

  12. The Mythology of Feedback

    Science.gov (United States)

    Adcroft, Andy

    2011-01-01

    Much of the general education and discipline-specific literature on feedback suggests that it is a central and important element of student learning. This paper examines feedback from a social process perspective and suggests that feedback is best understood through an analysis of the interactions between academics and students. The paper argues…

  13. Adaptive cascaded beam-based feedback at the SLC

    International Nuclear Information System (INIS)

    Himel, T.; Allison, S.; Grossberg, P.; Hendrickson, L.; Sass, R.; Shoaee, H.

    1993-05-01

    The SLAC Linear Collider now has a total of twenty-four beam-steering feedback loops used to keep the electron and positron beams on their desired trajectories. Seven of these loops measure and control the same beam as it proceeds down the linac through the arcs to the final focus. Ideally each loop should correct only for disturbances that occur between it and the immediate upstream loop. In fact, in the original system each loop corrected for all upstream disturbances. This resulted in undesirable over-correction and ringing. We added MIMO (Multiple Input Multiple Output) adaptive noise cancellers to separate the signal we wish to correct from disturbances further up-stream. This adaptive control improved performance in the 1992 run

  14. Process of preparing hydraulic cement

    Energy Technology Data Exchange (ETDEWEB)

    1919-12-11

    A process of preparing hydraulic cement from oil shale or shale coke is characterized in that the oil shale or shale coke after the distillation is burned long and hot to liberate the usual amount of carbonic acid and then is fine ground to obtain a slow hardening hydraulic cement.

  15. Control rod drive hydraulic device

    International Nuclear Information System (INIS)

    Takekawa, Toru.

    1994-01-01

    The device of the present invention can reliably prevent a possible erroneous withdrawal of control rod driving mechanism when the pressure of a coolant line is increased by isolation operation of hydraulic control units upon periodical inspection for a BWR type reactor. That is, a coolant line is connected to the downstream of a hydraulic supply device. The coolant line is connected to a hydraulic control unit. A coolant hydraulic detection device and a pressure setting device are disposed to the coolant line. A closing signal line and a returning signal line are disposed, which connect the hydraulic supply device and a flow rate control valve for the hydraulic setting device. In the device of the present invention, even if pressure of supplied coolants is elevated due to isolation of hydraulic control units, the elevation of the hydraulic pressure can be prevented. Accordingly, reliability upon periodical reactor inspection can be improved. Further, the facility is simplified and the installation to an existent facility is easy. (I.S.)

  16. Hydraulically centered control rod

    International Nuclear Information System (INIS)

    Horlacher, W.R.; Sampson, W.T.; Schukei, G.E.

    1981-01-01

    A control rod suspended to reciprocate in a guide tube of a nuclear fuel assembly has a hydraulic bearing formed at its lower tip. The bearing includes a plurality of discrete pockets on its outer surface into which a flow of liquid is continuously provided. In one embodiment the flow is induced by the pressure head in a downward facing chamber at the end of the bearing. In another embodiment the flow originates outside the guide tube. In both embodiments the flow into the pockets produces pressure differences across the bearing which counteract forces tending to drive the rod against the guide tube wall. Thus contact of the rod against the guide tube is avoided

  17. Equipment for hydraulic testing

    International Nuclear Information System (INIS)

    Jacobsson, L.; Norlander, H.

    1981-07-01

    Hydraulic testing in boreholes is one major task of the hydrogeological program in the Stripa Project. A new testing equipment for this purpose was constructed. It consists of a downhole part and a surface part. The downhole part consists of two packers enclosing two test-sections when inflated; one between the packers and one between the bottom packer and the bottom of the borehole. A probe for downhole electronics is also included in the downhole equipment together with electrical cable and nylon tubing. In order to perform shut-in and pulse tests with high accuracy a surface controlled downhole valve was constructed. The surface equipment consists of the data acquisition system, transducer amplifier and surface gauges. In the report detailed descriptions of each component in the whole testing equipment are given. (Auth.)

  18. Force Control Strategies in Hydraulically Actuated Legged Robots

    Directory of Open Access Journals (Sweden)

    Hector Montes

    2016-03-01

    Full Text Available In this contribution, several strategies of force control have been proposed to be implemented and evaluated in ROBOCLIMBER, a quadruped robot of large dimensions. A first group of strategies proposed in this paper is based on impedance control, which is intended to adapt the foot-ground contact forces according to the experimentally specified damping ratio and the undamped natural frequency. A second control strategy of interest for many practical cases is called the parallel force/position control, which has one inner loop position control and two external control loops, one of force and another of position. A third group of control strategies is the posture stabilization for ROBOCLIMBER using the feedback of the ZMP calculation and the position of its legs. Finally, a control strategy for the control of a quasi-static gait using ZMP feedback is proposed and tested by simulation.

  19. Stability, gain, and robustness in quantum feedback networks

    International Nuclear Information System (INIS)

    D'Helon, C.; James, M. R.

    2006-01-01

    In this paper we are concerned with the problem of stability for quantum feedback networks. We demonstrate in the context of quantum optics how stability of quantum feedback networks can be guaranteed using only simple gain inequalities for network components and algebraic relationships determined by the network. Quantum feedback networks are shown to be stable if the loop gain is less than one--this is an extension of the famous small gain theorem of classical control theory. We illustrate the simplicity and power of the small gain approach with applications to important problems of robust stability and robust stabilization

  20. Laser cooling in a feedback-controlled optical shaker

    International Nuclear Information System (INIS)

    Vilensky, Mark Y.; Averbukh, Ilya Sh.; Prior, Yehiam

    2006-01-01

    We explore the prospects of optical shaking, a recently suggested generic approach to laser cooling of neutral atoms and molecules. Optical shaking combines elements of Sisyphus cooling and of stochastic cooling techniques and is based on feedback-controlled interaction of particles with strong nonresonant laser fields. The feedback loop guarantees a monotonous energy decrease without a loss of particles. We discuss two types of feedback algorithms and provide an analytical estimation of their cooling rate. We study the robustness of optical shaking against noise and establish minimal stability requirements for the lasers. The analytical predictions are in a good agreement with the results of detailed numerical simulations

  1. A review of control strategies in closed-loop neuroprosthetic systems

    Directory of Open Access Journals (Sweden)

    James Wright

    2016-07-01

    Full Text Available It has been widely recognized that closed-loop neuroprosthetic systems achieve more favorable outcomes for users then equivalent open-loop devices. Improved performance of tasks, better usability and greater embodiment have all been reported in systems utilizing some form of feedback. However the interdisciplinary work on neuroprosthetic systems can lead to miscommunication due to similarities in well established nomenclature in different fields. Here we present a review of control strategies in existing experimental, investigational and clinical neuroprosthetic systems in order to establish a baseline and promote a common understanding of different feedback modes and closed-loop controllers. The first section provides a brief discussion of feedback control and control theory. The second section reviews the control strategies of recent Brain Machine Interfaces, neuromodulatory implants, neuroprosthetic systems and assistive neurorobotic devices. The final section examines the different approaches to feedback in current neuroprosthetic and neurorobotic systems.

  2. Conformal boundary loop models

    International Nuclear Information System (INIS)

    Jacobsen, Jesper Lykke; Saleur, Hubert

    2008-01-01

    We study a model of densely packed self-avoiding loops on the annulus, related to the Temperley-Lieb algebra with an extra idempotent boundary generator. Four different weights are given to the loops, depending on their homotopy class and whether they touch the outer rim of the annulus. When the weight of a contractible bulk loop x≡q+q -1 element of (-2,2], this model is conformally invariant for any real weight of the remaining three parameters. We classify the conformal boundary conditions and give exact expressions for the corresponding boundary scaling dimensions. The amplitudes with which the sectors with any prescribed number and types of non-contractible loops appear in the full partition function Z are computed rigorously. Based on this, we write a number of identities involving Z which hold true for any finite size. When the weight of a contractible boundary loop y takes certain discrete values, y r ≡([r+1] q )/([r] q ) with r integer, other identities involving the standard characters K r,s of the Virasoro algebra are established. The connection with Dirichlet and Neumann boundary conditions in the O(n) model is discussed in detail, and new scaling dimensions are derived. When q is a root of unity and y=y r , exact connections with the A m type RSOS model are made. These involve precise relations between the spectra of the loop and RSOS model transfer matrices, valid in finite size. Finally, the results where y=y r are related to the theory of Temperley-Lieb cabling

  3. Quantifying the ice-albedo feedback through decoupling

    Science.gov (United States)

    Kravitz, B.; Rasch, P. J.

    2017-12-01

    The ice-albedo feedback involves numerous individual components, whereby warming induces sea ice melt, inducing reduced surface albedo, inducing increased surface shortwave absorption, causing further warming. Here we attempt to quantify the sea ice albedo feedback using an analogue of the "partial radiative perturbation" method, but where the governing mechanisms are directly decoupled in a climate model. As an example, we can isolate the insulating effects of sea ice on surface energy and moisture fluxes by allowing sea ice thickness to change but fixing Arctic surface albedo, or vice versa. Here we present results from such idealized simulations using the Community Earth System Model in which individual components are successively fixed, effectively decoupling the ice-albedo feedback loop. We isolate the different components of this feedback, including temperature change, sea ice extent/thickness, and air-sea exchange of heat and moisture. We explore the interactions between these different components, as well as the strengths of the total feedback in the decoupled feedback loop, to quantify contributions from individual pieces. We also quantify the non-additivity of the effects of the components as a means of investigating the dominant sources of nonlinearity in the ice-albedo feedback.

  4. Using deflation in the pole assignment problem with output feedback

    Science.gov (United States)

    Miminis, George

    1989-01-01

    A direct algorithm is suggested for the computation of a linear output feedback for a multi input, multi output system such that the resultant closed-loop matrix has eigenvalues that include a specified set of eigenvalues. The algorithm uses deflation based on unitary similarity transformations. Thus researchers hope the algorithm is numerically stable; however, this has not been proven as yet.

  5. Multi-model MPC with output feedback

    Directory of Open Access Journals (Sweden)

    J. M. Perez

    2014-03-01

    Full Text Available In this work, a new formulation is presented for the model predictive control (MPC of a process system that is represented by a finite set of models, each one corresponding to a different operating point. The general case is considered of systems with stable and integrating outputs in closed-loop with output feedback. For this purpose, the controller is based on a non-minimal order model where the state is built with the measured outputs and the manipulated inputs of the control system. Therefore, the state can be considered as perfectly known and, consequently, there is no need to include a state observer in the control loop. This property of the proposed modeling approach is convenient to extend previous stability results of the closed loop system with robust MPC controllers based on state feedback. The controller proposed here is based on the solution of two optimization problems that are solved sequentially at the same time step. The method is illustrated with a simulated example of the process industry. The rigorous simulation of the control of an adiabatic flash of a multi-component hydrocarbon mixture illustrates the application of the robust controller. The dynamic simulation of this process is performed using EMSO - Environment Model Simulation and Optimization. Finally, a comparison with a linear MPC using a single model is presented.

  6. Start-up of a cold loop in a VVER-440, the 7th AER benchmark calculation with HEXTRAN-SMABRE-PORFLO

    International Nuclear Information System (INIS)

    Hovi, Ville; Taivassalo, Veikko; Haemaelaeinen, Anitta; Raety, Hanna; Syrjaelahti, Elina

    2017-01-01

    The 7 th dynamic AER benchmark is the first in which three-dimensional thermal hydraulics codes are supposed to be applied. The aim is to get a more precise core inlet temperature profile than the sector temperatures available typically with system codes. The benchmark consists of a start-up of the sixth, isolated loop in a VVER-440 plant. The isolated loop initially contains cold water without boric acid and the start-up leads to a somewhat asymmetrical core power increase due to feedbacks in the core. In this study, the 7 th AER benchmark is calculated with the three-dimensional nodal reactor dynamics code HEXTRAN-SMABRE coupled with the porous computational fluid dynamics code PORFLO. These three codes are developed at VTT. A novel two-way coupled simulation of the 7 th AER benchmark was performed successfully demonstrating the feasibility and advantages of the new reactor analysis framework. The modelling issues for this benchmark are reported and some evaluation against the previously reported comparisons between the system codes is provided.

  7. Start-up of a cold loop in a VVER-440, the 7{sup th} AER benchmark calculation with HEXTRAN-SMABRE-PORFLO

    Energy Technology Data Exchange (ETDEWEB)

    Hovi, Ville; Taivassalo, Veikko; Haemaelaeinen, Anitta; Raety, Hanna; Syrjaelahti, Elina [VTT Technical Research Centre of Finland Ltd, VTT (Finland)

    2017-09-15

    The 7{sup th} dynamic AER benchmark is the first in which three-dimensional thermal hydraulics codes are supposed to be applied. The aim is to get a more precise core inlet temperature profile than the sector temperatures available typically with system codes. The benchmark consists of a start-up of the sixth, isolated loop in a VVER-440 plant. The isolated loop initially contains cold water without boric acid and the start-up leads to a somewhat asymmetrical core power increase due to feedbacks in the core. In this study, the 7{sup th} AER benchmark is calculated with the three-dimensional nodal reactor dynamics code HEXTRAN-SMABRE coupled with the porous computational fluid dynamics code PORFLO. These three codes are developed at VTT. A novel two-way coupled simulation of the 7{sup th} AER benchmark was performed successfully demonstrating the feasibility and advantages of the new reactor analysis framework. The modelling issues for this benchmark are reported and some evaluation against the previously reported comparisons between the system codes is provided.

  8. Global output feedback stabilisation of stochastic high-order feedforward nonlinear systems with time-delay

    Science.gov (United States)

    Zhang, Kemei; Zhao, Cong-Ran; Xie, Xue-Jun

    2015-12-01

    This paper considers the problem of output feedback stabilisation for stochastic high-order feedforward nonlinear systems with time-varying delay. By using the homogeneous domination theory and solving several troublesome obstacles in the design and analysis, an output feedback controller is constructed to drive the closed-loop system globally asymptotically stable in probability.

  9. Bandwidth limitations in current mode and voltage mode integrated feedback amplifiers

    DEFF Research Database (Denmark)

    Bruun, Erik

    1995-01-01

    loop bandwidth remains constant for a feedback amplifier. The constant-bandwidth relations of such amplifier designs are reviewed in this paper and they are combined with the constraints imposed by technology when the feedback amplifier is to be designed in an integrated technology. From this analysis...

  10. A novel approach to negative feedback in RX front-ends

    DEFF Research Database (Denmark)

    Vandi, Luca; Andreani, Pietro; Tired, Tobias

    2006-01-01

    A new approach to negative feedback is proposed and applied to active mixer cells based on Gilbert multiplier. The feedback can be exploited in several ways, and different configurations are derived. A dual-loop topology provides a solution for inductor-less broad-band receiver stages. The nature...

  11. Rail-to-rail low-power fully differential OTA utilizing adaptive biasing and partial feedback

    DEFF Research Database (Denmark)

    Tuan Vu, Cao; Wisland, Dag T.; Lande, Tor Sverre

    consumption. The DC-gain of the proposed OTA is improved by adding a partial feedback loop. A Common-Mode Feedback (CMFB) circuit is required for fully differential rail-to-rail operation. Simulations show that the OTA topology has a low stand-by power consumption of 96μW and a high FoM of 3.84 [(V...

  12. Tracking control of the hydraulically actuated flexible manipulator

    International Nuclear Information System (INIS)

    Kwon, D.S.; Babcock, S.M.; Burks, B.L.; Kress, R.L.

    1995-01-01

    The remediation of single-shell radioactive waste storage tanks is one of the urgent tasks of the Department of Energy that challenge state-of-the-art equipment and methods. The use of long-reach manipulators is being seriously considered for this remediation task. Because high payload capacity and high length-to-cross-section ratio requirements, these long-reach manipulator systems are expected to use hydraulic actuators and to exhibit significant structural flexibility. The controller has been designed to compensate for the hydraulic actuator dynamics by using a load-compensated velocity feedforward loop and to increase the bandwidth by using a pressure feed backloop. Shaping filter techniques have been applied as a feedforward controller to avoid structural vibrations during operation. Among various types of shaping filter methods investigated an approach, referred to as a ''feedforward simulation filter'' that uses embedded simulation, has been presented

  13. Observer-Based Robust Control for Hydraulic Velocity Control System

    Directory of Open Access Journals (Sweden)

    Wei Shen

    2013-01-01

    Full Text Available This paper investigates the problems of robust stabilization and robust control for the secondary component speed control system with parameters uncertainty and load disturbance. The aim is to enhance the control performance of hydraulic system based on Common Pressure Rail (CPR. Firstly, a mathematical model is presented to describe the hydraulic control system. Then a novel observer is proposed, and an observed-based control strategy is designed such that the closed-loop system is asymptotically stable and satisfies the disturbance attenuation level. The condition for the existence of the developed controller can by efficiently solved by using the MATLAB software. Finally, simulation results are provided to demonstrate the effectiveness of the proposed method.

  14. Thermal-hydraulic tests for reactor safety system

    International Nuclear Information System (INIS)

    Chun, Se Young; Chung, Moon Ki; Baek, Won Pil

    2002-05-01

    Tests for the safety depressurization system, Sparger adopted for the Korean next generation reactor, APR1400 are carried out for several geometries with the B and C (Blowdown and Condensation) facility in the condition of high temperature and pressure and with a small test facility in the condition of atmospheric temperature and pressure. Tests for the critical heat flux are performed with the RCS(Reactor Coolant System) facility as well as with the Freon CHF Loop in the condition of high temperature and pressure. The atmospheric temperature and pressure facility is utilized for development of the high standard thermal hydraulic measurement technology. The optical method is developed to measure the local thermal-hydraulic behavior for the single and two-phase boiling phenomena

  15. Efficient numerical method for district heating system hydraulics

    International Nuclear Information System (INIS)

    Stevanovic, Vladimir D.; Prica, Sanja; Maslovaric, Blazenka; Zivkovic, Branislav; Nikodijevic, Srdjan

    2007-01-01

    An efficient method for numerical simulation and analyses of the steady state hydraulics of complex pipeline networks is presented. It is based on the loop model of the network and the method of square roots for solving the system of linear equations. The procedure is presented in the comprehensive mathematical form that could be straightforwardly programmed into a computer code. An application of the method to energy efficiency analyses of a real complex district heating system is demonstrated. The obtained results show a potential for electricity savings in pumps operation. It is shown that the method is considerably more effective than the standard Hardy Cross method still widely used in engineering practice. Because of the ease of implementation and high efficiency, the method presented in this paper is recommended for hydraulic steady state calculations of complex networks

  16. Hydraulic Actuators with Autonomous Hydraulic Supply for the Mainline Aircrafts

    Directory of Open Access Journals (Sweden)

    I. S. Shumilov

    2014-01-01

    Full Text Available Applied in the aircraft control systems, hydraulic servo actuators with autonomous hydraulic supply, so-called, hydraulic actuators of integrated configuration, i.e. combination of a source of hydraulic power and its load in the single unit, are aimed at increasing control system reliability both owing to elimination of the pipelines connecting the actuator to the hydraulic supply source, and owing to avoidance of influence of other loads failure on the actuator operability. Their purpose is also to raise control system survivability by eliminating the long pipeline communications and their replacing for the electro-conductive power supply system, thus reducing the vulnerability of systems. The main reason for a delayed application of the hydraulic actuators in the cutting-edge aircrafts was that such aircrafts require hydraulic actuators of considerably higher power with considerable heat releases, which caused an unacceptable overheat of the hydraulic actuators. Positive and negative sides of the hydraulic actuators, their alternative options of increased reliability and survivability, local hydraulic systems as an advanced alternative to independent hydraulic actuators are considered.Now to use hydraulic actuators in mainline aircrafts is inexpedient since there are the unfairly large number of the problems reducing, first and last, safety of flights, with no essential weight and operational advantages. Still works to create competitive hydraulic actuators ought to be continued.Application of local hydraulic systems (LHS will allow us to reduce length of pressure head and drain pipelines and mass of pipelines, as well as to raise their general fail-safety and survivability. Application of the LHS principle will allow us to use a majority of steering drive advantages. It is necessary to allocate especially the following:- ease of meeting requirements for the non-local spread of the engine weight;- essentially reducing length and weight of

  17. Follower-Centered Perspective on Feedback: Effects of Feedback Seeking on Identification and Feedback Environment

    OpenAIRE

    Gong, Zhenxing; Li, Miaomiao; Qi, Yaoyuan; Zhang, Na

    2017-01-01

    In the formation mechanism of the feedback environment, the existing research pays attention to external feedback sources and regards individuals as objects passively accepting feedback. Thus, the external source fails to realize the individuals’ need for feedback, and the feedback environment cannot provide them with useful information, leading to a feedback vacuum. The aim of this study is to examine the effect of feedback-seeking by different strategies on the supervisor-feedback environme...

  18. Digital limiter for a self-excited loop

    International Nuclear Information System (INIS)

    Joshi, G.; Singh, P.; Agarwal, V.; Kumar, G.

    2015-01-01

    Limiter is one of the main signal processing modules of a self-excited loop (SEL). It plays a crucial role in initiating and stabilizing the amplitude of the RF field in a free running SEL. In a recently reported implementation of a self excited loop in digital domain, the limiter has been realized at based band in the form of a feedback loop. This feedback loop stabilizes the amplitude of the RF phasor present at its input without affecting its phase. In the present work we study the suitability of this implementation of limiter through analysis and simulations. An approximate equivalent model of an SEL, incorporating the digital limiter, is created in analog domain. It is demonstrated that even in the presence for large transients, such as, at the start up of oscillations, SEL continues to exhibit smooth and predictable response. In free running mode of operation the coupling from loop oscillation frequency change to resonator field amplitude change is absent, thus avoiding instability due to electro-mechanical coupling. In the locked mode, the transmission of amplitude jitter through the limiter is far exceeded by that through the controller gain thereby keeping the behavior of the digital SEL close to its analog counterpart. (author)

  19. Loop quantum gravity

    International Nuclear Information System (INIS)

    Pullin, J.

    2015-01-01

    Loop quantum gravity is one of the approaches that are being studied to apply the rules of quantum mechanics to the gravitational field described by the theory of General Relativity . We present an introductory summary of the main ideas and recent results. (Author)

  20. Blind Loop Syndrome

    Science.gov (United States)

    ... or scleroderma involving the small intestine History of radiation therapy to the abdomen Diabetes Diverticulosis of the small intestine Complications A blind loop can cause escalating problems, including: Poor absorption of fats. Bacteria in your small intestine break down the bile ...

  1. Improving Loop Dependence Analysis

    DEFF Research Database (Denmark)

    Jensen, Nicklas Bo; Karlsson, Sven

    2017-01-01

    Programmers can no longer depend on new processors to have significantly improved single-thread performance. Instead, gains have to come from other sources such as the compiler and its optimization passes. Advanced passes make use of information on the dependencies related to loops. We improve th...

  2. Loop Quantum Gravity

    Directory of Open Access Journals (Sweden)

    Rovelli Carlo

    1998-01-01

    Full Text Available The problem of finding the quantum theory of the gravitational field, and thus understanding what is quantum spacetime, is still open. One of the most active of the current approaches is loop quantum gravity. Loop quantum gravity is a mathematically well-defined, non-perturbative and background independent quantization of general relativity, with its conventional matter couplings. Research in loop quantum gravity today forms a vast area, ranging from mathematical foundations to physical applications. Among the most significant results obtained are: (i The computation of the physical spectra of geometrical quantities such as area and volume, which yields quantitative predictions on Planck-scale physics. (ii A derivation of the Bekenstein-Hawking black hole entropy formula. (iii An intriguing physical picture of the microstructure of quantum physical space, characterized by a polymer-like Planck scale discreteness. This discreteness emerges naturally from the quantum theory and provides a mathematically well-defined realization of Wheeler's intuition of a spacetime ``foam''. Long standing open problems within the approach (lack of a scalar product, over-completeness of the loop basis, implementation of reality conditions have been fully solved. The weak part of the approach is the treatment of the dynamics: at present there exist several proposals, which are intensely debated. Here, I provide a general overview of ideas, techniques, results and open problems of this candidate theory of quantum gravity, and a guide to the relevant literature.

  3. Overview of Loop Heat Pipe Operation

    Science.gov (United States)

    Ku, Jentung

    1999-01-01

    Loop heat pipes (LHP's) are two-phase heat transfer devices that utilize the evaporation and condensation of a working fluid to transfer heat, and the capillary forces developed in the porous wicks to circulate the fluid. The LHP was first developed in the former Soviet Union in the early 1980s, about the same time that the capillary pumped loop (CPL) was developed in the United States. The LHP is known for its high pumping capability and robust operation mainly due to the use of fine-pored metal wicks and an integral evaporator/hydro-accumulator design. The LHP technology is rapidly gaining acceptance in aerospace community. It is the baseline design for thermal control of several spacecraft, including NASA's GLAS and Chemistry, ESA's ATLID, CNES' STENTOR, RKA's OBZOR, and several commercial satellites. Numerous LHP papers have been published since the mid-1980's. Most papers presented test results and discussions on certain specific aspects of the LHP operation. LHP's and CPL's show many similarities in their operating principles and performance characteristics. However, they also display significant differences in many aspects of their operation. Some of the LHP behaviors may seem strange or mysterious, even to experienced CPL practitioners. The main purpose of this paper is to present a systematic description of the operating principles and thermal-hydraulic behaviors of LHP'S. LHP operating principles will be given first, followed by a description of the thermal-hydraulics involved in LHP operation. Operating characteristics and important parameters affecting the LHP operation will then be described in detail. Peculiar behaviors of the LHP, including temperature hysteresis and temperature overshoot during start-up, will be explained. For simplicity, most discussions will focus upon LHP's with a single evaporator and a single condenser, but devices with multiple evaporators and condensers will also be discussed. Similarities and differences between LHP's and

  4. Hydraulic design of Three Gorges right bank powerhouse turbine for improvement of hydraulic stability

    International Nuclear Information System (INIS)

    Shi, Q

    2010-01-01

    This paper presents the hydraulic design of Three Gorges Right Bank Powerhouse turbine for improvement of hydraulic stability. The technical challenges faced in the hydraulic design of the turbine are given. The method of hydraulic design for improving the hydraulic stability and particularly for eliminating the upper part load pressure pulsations is clarified. The final hydraulic design results of Three Gorges Right Bank Powerhouse turbine based on modern hydraulic design techniques are presented.

  5. Hydraulic design of Three Gorges right bank powerhouse turbine for improvement of hydraulic stability

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Q, E-mail: qhshi@dfem.com.c [Dong Fang Electrical Machinery Co., Ltd., DEC 188, Huanghe West Road, Deyang, 618000 (China)

    2010-08-15

    This paper presents the hydraulic design of Three Gorges Right Bank Powerhouse turbine for improvement of hydraulic stability. The technical challenges faced in the hydraulic design of the turbine are given. The method of hydraulic design for improving the hydraulic stability and particularly for eliminating the upper part load pressure pulsations is clarified. The final hydraulic design results of Three Gorges Right Bank Powerhouse turbine based on modern hydraulic design techniques are presented.

  6. RF feedback for KEKB

    Energy Technology Data Exchange (ETDEWEB)

    Ezura, Eizi; Yoshimoto, Shin-ichi; Akai, Kazunori [National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan)

    1996-08-01

    This paper describes the present status of the RF feedback development for the KEK B-Factory (KEKB). A preliminary experiment concerning the RF feedback using a parallel comb-filter was performed through a choke-mode cavity and a klystron. The RF feedback has been tested using the beam of the TRISTAN Main Ring, and has proved to be effective in damping the beam instability. (author)

  7. Neural cryptography with feedback.

    Science.gov (United States)

    Ruttor, Andreas; Kinzel, Wolfgang; Shacham, Lanir; Kanter, Ido

    2004-04-01

    Neural cryptography is based on a competition between attractive and repulsive stochastic forces. A feedback mechanism is added to neural cryptography which increases the repulsive forces. Using numerical simulations and an analytic approach, the probability of a successful attack is calculated for different model parameters. Scaling laws are derived which show that feedback improves the security of the system. In addition, a network with feedback generates a pseudorandom bit sequence which can be used to encrypt and decrypt a secret message.

  8. Feedback and Incentives:

    DEFF Research Database (Denmark)

    Eriksson, Tor Viking; Poulsen, Anders; Villeval, Marie-Claire

    This paper experimentally investigates the impact of different pay and relative performance information policies on employee effort. We explore three information policies: No feedback about relative performance, feedback given halfway through the production period, and continuously updated feedba...... of positive peer effects since the underdogs almost never quit the competition even when lagging significantly behind, and frontrunners do not slack off. Moreover, in both pay schemes information feedback reduces the quality of the low performers' work....

  9. Hydraulic release oil tool

    International Nuclear Information System (INIS)

    Mims, M.G.; Mueller, M.D.; Ehlinger, J.C.

    1992-01-01

    This patent describes a hydraulic release tool. It comprises a setting assembly; a coupling member for coupling to drill string or petroleum production components, the coupling member being a plurality of sockets for receiving the dogs in the extended position and attaching the coupling member the setting assembly; whereby the setting assembly couples to the coupling member by engagement of the dogs in the sockets of releases from and disengages the coupling member in movement of the piston from its setting to its reposition in response to a pressure in the body in exceeding the predetermined pressure; and a relief port from outside the body into its bore and means to prevent communication between the relief port and the bore of the body axially of the piston when the piston is in the setting position and to establish such communication upon movement of the piston from the setting position to the release position and reduce the pressure in the body bore axially of the piston, whereby the reduction of the pressure signals that the tool has released the coupling member

  10. General, database-driven fast-feedback system for the Stanford Linear Collider

    International Nuclear Information System (INIS)

    Rouse, F.; Allison, S.; Castillo, S.; Gromme, T.; Hall, B.; Hendrickson, L.; Himel, T.; Krauter, K.; Sass, B.; Shoaee, H.

    1991-05-01

    A new feedback system has been developed for stabilizing the SLC beams at many locations. The feedback loops are designed to sample and correct at the 60 Hz repetition rate of the accelerator. Each loop can be distributed across several of the standard 80386 microprocessors which control the SLC hardware. A new communications system, KISNet, has been implemented to pass signals between the microprocessors at this rate. The software is written in a general fashion using the state space formalism of digital control theory. This allows a new loop to be implemented by just setting up the online database and perhaps installing a communications link. 3 refs., 4 figs

  11. Experimental study of the pressure discharge process for the hydraulic control rod drive system stepped cylinder

    International Nuclear Information System (INIS)

    Wang, Jinhua; Bo, Hanliang; Zheng, Wenxiang

    2002-01-01

    The pressure discharge process from the stepped cylinder of the Hydraulic Control Rod Drive System (HCRDS) was studied experimentally in the HCRDS experimental loop for the 200 MW Nuclear Heating Reactor (NHR-200). The results showed that the differential pressure between the outside and the inside of the stepped cylinder increased rapidly to the desired value so that the force induced by the differential pressure which pushes the out tube of stepped cylinder was large enough. Therefore, if the hydraulic control rod were jammed, the pressure could push the hydraulic control rod to overcome the frictional resistance to insert the control rod into the reactor core. The experimental results verified that this design would solve the problem of hydraulic control rod jamming during an accident. (author)

  12. Analysis and experimental study on hydraulic balance characteristics in density lock

    International Nuclear Information System (INIS)

    Gu Haifeng; Yan Changqi; Sun Furong

    2009-01-01

    Through the simplified theoretical model, the hydraulic balance condition which should be met in the density lock is obtained, when reactor operates normally and density lock is closed. The main parameters influencing this condition are analyzed, and the results show that the hydraulic balance in the density lock is characterized with self-stability in a certain range. Meantime, a simulating experimental loop is built and experimental verification on the self-stability characteristic is done. Moreover, experimental study is done on the conditions of flow change of work fluids in the primary circuit in the process of stable operations. The experimental results show that the hydraulic balance in the density lock can recovered quickly, depending on the self-stability characteristic without influences on the sealing performance of density lock and normal operation of reactor, after the change of operation parameters breaks the hydraulic balance. (authors)

  13. Closed-loop, open-source electrophysiology

    Directory of Open Access Journals (Sweden)

    John D Rolston

    2010-09-01

    Full Text Available Multiple extracellular microelectrodes (multi-electrode arrays, or MEAs effectively record rapidly varying neural signals, and can also be used for electrical stimulation. Multi-electrode recording can serve as artificial output (efferents from a neural system, while complex spatially and temporally targeted stimulation can serve as artificial input (afferents to the neuronal network. Multi-unit or local field potential recordings can not only be used to control real world artifacts, such as prostheses, computers or robots, but can also trigger or alter subsequent stimulation. Real-time feedback stimulation may serve to modulate or normalize aberrant neural activity, to induce plasticity, or to serve as artificial sensory input. Despite promising closed-loop applications, commercial electrophysiology systems do not yet take advantage of the bidirectional capabilities of multi-electrodes, especially for use in freely moving animals. We addressed this lack of tools for closing the loop with NeuroRighter, an open-source system including recording hardware, stimulation hardware, and control software with a graphical user interface. The integrated system is capable of multi-electrode recording and simultaneous patterned microstimulation triggered by recordings with minimal stimulation artifact. The potential applications of closed-loop systems as research tools and clinical treatments are broad; we provide one example where epileptic activity recorded by a multi-electrode probe is used to trigger targeted stimulation, via that probe, to freely moving rodents.

  14. Policy Feedback System (PFS)

    Data.gov (United States)

    Social Security Administration — The Policy Feedback System (PFS) is a web application developed by the Office of Disability Policy Management Information (ODPMI) team that gathers empirical data...

  15. Feedback stabilization initiative

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    Much progress has been made in attaining high confinement regimes in magnetic confinement devices. These operating modes tend to be transient, however, due to the onset of MHD instabilities, and their stabilization is critical for improved performance at steady state. This report describes the Feedback Stabilization Initiative (FSI), a broad-based, multi-institutional effort to develop and implement methods for raising the achievable plasma betas through active MHD feedback stabilization. A key element in this proposed effort is the Feedback Stabilization Experiment (FSX), a medium-sized, national facility that would be specifically dedicated to demonstrating beta improvement in reactor relevant plasmas by using a variety of MHD feedback stabilization schemes.

  16. Feedback stabilization initiative

    International Nuclear Information System (INIS)

    1997-06-01

    Much progress has been made in attaining high confinement regimes in magnetic confinement devices. These operating modes tend to be transient, however, due to the onset of MHD instabilities, and their stabilization is critical for improved performance at steady state. This report describes the Feedback Stabilization Initiative (FSI), a broad-based, multi-institutional effort to develop and implement methods for raising the achievable plasma betas through active MHD feedback stabilization. A key element in this proposed effort is the Feedback Stabilization Experiment (FSX), a medium-sized, national facility that would be specifically dedicated to demonstrating beta improvement in reactor relevant plasmas by using a variety of MHD feedback stabilization schemes

  17. Ecogeomorphic feedbacks in regrowth of travertine step-pool morphology after dam decommissioning, Fossil Creek, Arizona

    Science.gov (United States)

    Fuller, Brian M.; Sklar, Leonard S.; Compson, Zacchaeus G.; Adams, Kenneth J.; Marks, Jane C.; Wilcox, Andrew C.

    2011-03-01

    The linkages between fluvial geomorphology and aquatic ecosystems are commonly conceptualized as a one-way causal chain in which geomorphic processes create the physical template for ecological dynamics. In streams with a travertine step-pool morphology, however, biotic processes strongly influence the formation and growth of travertine dams, creating the potential for numerous feedbacks. Here we take advantage of the decommissioning of a hydroelectric project on Fossil Creek, Arizona, where restoration of CaCO 3-rich baseflow has triggered rapid regrowth of travertine dams, to explore the interactions between biotic and abiotic factors in travertine morphodynamics. We consider three conceptual frameworks, where biotic factors independently modulate the rate of physical and chemical processes that produce travertine dams; combine with abiotic factors in a set of feedback loops; and work in opposition to abiotic processes, such that the travertine step-pool morphology reflects a dynamic balance between dominantly-biotic constructive processes and dominantly-abiotic destructive processes. We consider separately three phases of an idealized life cycle of travertine dams: dam formation, growth, and destruction by erosive floods. Dam formation is catalyzed by abiotic factors (e.g. channel constrictions, and bedrock steps) and biotic factors (e.g. woody debris, and emergent vegetation). From measurements of changes over time in travertine thickness on a bedrock step, we find evidence for a positive feedback between flow hydraulics and travertine accrual. Measurements of organic content in travertine samples from this step show that algal growth contributes substantially to travertine accumulation and suggest that growth is most rapid during seasonal algal blooms. To document vertical growth of travertine dams, we embedded 252 magnets into nascent travertine dams, along a 10 km stretch of river. Growth rates are calculated from changes over time in the magnetic field

  18. Random walk loop soups and conformal loop ensembles

    NARCIS (Netherlands)

    van de Brug, T.; Camia, F.; Lis, M.

    2016-01-01

    The random walk loop soup is a Poissonian ensemble of lattice loops; it has been extensively studied because of its connections to the discrete Gaussian free field, but was originally introduced by Lawler and Trujillo Ferreras as a discrete version of the Brownian loop soup of Lawler and Werner, a

  19. HYDRAULICS, SHELBY COUNTY, KENTUCKY, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydraulic data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

  20. HYDRAULICS, MEADE COUNTY, KENTUCKY, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydraulic data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

  1. The Process of Hydraulic Fracturing

    Science.gov (United States)

    Hydraulic fracturing, know as fracking or hydrofracking, produces fractures in a rock formation by pumping fluids (water, proppant, and chemical additives) at high pressure down a wellbore. These fractures stimulate the flow of natural gas or oil.

  2. Steam generator thermal-hydraulics

    International Nuclear Information System (INIS)

    Inch, W.W.; Scott, D.A.; Carver, M.B.

    1980-01-01

    This paper discusses a code for detailed numerical modelling of steam generator thermal-hydraulics, and describes related experimental programs designed to promote in-depth understanding of three-dimensional two-phase flow. (auth)

  3. Advanced Performance Hydraulic Wind Energy

    Science.gov (United States)

    Jones, Jack A.; Bruce, Allan; Lam, Adrienne S.

    2013-01-01

    The Jet Propulsion Laboratory, California Institute of Technology, has developed a novel advanced hydraulic wind energy design, which has up to 23% performance improvement over conventional wind turbine and conventional hydraulic wind energy systems with 5 m/sec winds. It also has significant cost advantages with levelized costs equal to coal (after carbon tax rebate). The design is equally applicable to tidal energy systems and has passed preliminary laboratory proof-of-performance tests, as funded by the Department of Energy.

  4. Robust Prediction of Hydraulic Roughness

    Science.gov (United States)

    2011-03-01

    Manning’s n were required as input for further hydraulic analyses with HEC - RAS . HYDROCAL was applied to compare different estimates of resistance... River Restoration Science Synthesis (NRRSS) demonstrated that, in 2007, river and stream restoration projects and funding were at an all time high...behavior makes this parameter very difficult to quan- tify repeatedly and accurately. A fundamental concept of hydraulic theory in the context of river

  5. Numerical Simulation of the Oscillations in a Mixer: An Internal Aeroacoustic Feedback System

    Science.gov (United States)

    Jorgenson, Philip C. E.; Loh, Ching Y.

    2004-01-01

    The space-time conservation element and solution element method is employed to numerically study the acoustic feedback system in a high temperature, high speed wind tunnel mixer. The computation captures the self-sustained feedback loop between reflecting Mach waves and the shear layer. This feedback loop results in violent instabilities that are suspected of causing damage to some tunnel components. The computed frequency is in good agreement with the available experimental data. The physical phenomena are explained based on the numerical results.

  6. Numerical study on identification of transfer functions in a feedback system and model reduction

    International Nuclear Information System (INIS)

    Kishida, Kuniharu

    1997-01-01

    Identification of transfer function matrices in a feedback system is discussed by using the singular value decomposition of Hankel matrix from the viewpoint of inverse problems. A method of model reduction is considered, and selection criteria are proposed for identification of them. Transformation formula between open loop and closed loop transfer function matrices are determined from the feedback loop structure, and they are needed for identification of open loop transfer function matrices under such a condition where the feedback system is in a minimum phase. Though the identifiability of open loop transfer function matrices can be examined in the framework of innovation model equivalent to the feedback system, there are pole-zero cancellations in the identification of them. The method to reduce a model order of an open loop transfer function is discussed by using the singular value decomposition of a gramian given by the open loop transfer function with higher degree. To check reliability of the present algorithm, a simulation study is performed for an example. (author)

  7. Simulation of proportional control of hydraulic actuator using digital hydraulic valves

    Science.gov (United States)

    Raghuraman, D. R. S.; Senthil Kumar, S.; Kalaiarasan, G.

    2017-11-01

    Fluid power systems using oil hydraulics in earth moving and construction equipment have been using proportional and servo control valves for a long time to achieve precise and accurate position control backed by system performance. Such valves are having feedback control in them and exhibit good response, sensitivity and fine control of the actuators. Servo valves and proportional valves are possessing less hysteresis when compared to on-off type valves, but when the servo valve spools get stuck in one position, a high frequency called as jitter is employed to bring the spool back, whereas in on-off type valves it requires lesser technology to retract the spool. Hence on-off type valves are used in a technology known as digital valve technology, which caters to precise control on slow moving loads with fast switching times and with good flow and pressure control mimicking the performance of an equivalent “proportional valve” or “servo valve”.

  8. Coupled 3D neutronics/thermal hydraulics modeling of the SAFARI-1 MTR

    International Nuclear Information System (INIS)

    Rosenkrantz, Adam; Avramova, Maria; Ivanov, Kostadin; Prinsloo, Rian; Botes, Danniëll; Elsakhawy, Khalid

    2014-01-01

    Highlights: • Development of 3D coupled neutronics/thermal–hydraulic model of SAFARI-1. • Verification of 3D steady-state NEM based neutronics model for SAFARI-1. • Verification of 3D COBRA-TF based thermal–hydraulic model of SAFARI-1. • Quantification of the effect of correct modeling of thermal–hydraulic feedback. - Abstract: The purpose of this study was to develop a coupled accurate multi-physics model of the SAFARI-1 Material Testing Reactor (MTR), a facility that is used for both research and the production of medical isotopes. The model was developed as part of the SAFARI-1 benchmarking project as a cooperative effort between the Pennsylvania State University (PSU) and the South African Nuclear Energy Corporation (Necsa). It was created using a multi-physics coupling of state of the art nuclear reactor simulation tools, consisting of a neutronics code and a thermal hydraulics code. The neutronics tool used was the PSU code NEM, and the results from this component were verified using the Necsa neutronics code OSCAR-4, which is utilized for SAFARI-1 core design and fuel management. On average, the multiplication factors of the neutronics models agreed to within 5 pcm and the radial assembly-averaged powers agreed to within 0.2%. The thermal hydraulics tool used was the PSU version of COBRA-TF (CTF) sub-channel code, and the results of this component were verified against another thermal hydraulics code, the RELAP5-3D system code, used at Necsa for thermal–hydraulics analysis of SAFARI-1. Although only assembly-averaged results from RELAP5-3D were available, they fell within the range of values for the corresponding assemblies in the comprehensive CTF solution. This comparison allows for the first time to perform a quantification of steady-state errors for a low-powered MTR with an advanced thermal–hydraulic code such as CTF on a per-channel basis as compared to simpler and coarser-mesh RELAP5-3D modeling. Additionally, a new cross section

  9. Scaling Analysis of the Single-Phase Natural Circulation: the Hydraulic Similarity

    International Nuclear Information System (INIS)

    Yu, Xin-Guo; Choi, Ki-Yong

    2015-01-01

    These passive safety systems all rely on the natural circulation to cool down the reactor cores during an accident. Thus, a robust and accurate scaling methodology must be developed and employed to both assist in the design of a scaled-down test facility and guide the tests in order to mimic the natural circulation flow of its prototype. The natural circulation system generally consists of a heat source, the connecting pipes and several heat sinks. Although many applauding scaling methodologies have been proposed during last several decades, few works have been dedicated to systematically analyze and exactly preserve the hydraulic similarity. In the present study, the hydraulic similarity analyses are performed at both system and local level. By this mean, the scaling criteria for the exact hydraulic similarity in a full-pressure model have been sought. In other words, not only the system-level but also the local-level hydraulic similarities are pursued. As the hydraulic characteristics of a fluid system is governed by the momentum equation, the scaling analysis starts with it. A dimensionless integral loop momentum equation is derived to obtain the dimensionless numbers. In the dimensionless momentum equation, two dimensionless numbers, the dimensionless flow resistance number and the dimensionless gravitational force number, are identified along with a unique hydraulic time scale, characterizing the system hydraulic response. A full-height full-pressure model is also made to see which model among the full-height model and reduced-height model can preserve the hydraulic behavior of the prototype. From the dimensionless integral momentum equation, a unique hydraulic time scale, which characterizes the hydraulic response of a single-phase natural circulation system, is identified along with two dimensionless parameters: the dimensionless flow resistance number and the dimensionless gravitational force number. By satisfying the equality of both dimensionless numbers

  10. Scaling Analysis of the Single-Phase Natural Circulation: the Hydraulic Similarity

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Xin-Guo; Choi, Ki-Yong [KAERI, Daejeon (Korea, Republic of)

    2015-05-15

    These passive safety systems all rely on the natural circulation to cool down the reactor cores during an accident. Thus, a robust and accurate scaling methodology must be developed and employed to both assist in the design of a scaled-down test facility and guide the tests in order to mimic the natural circulation flow of its prototype. The natural circulation system generally consists of a heat source, the connecting pipes and several heat sinks. Although many applauding scaling methodologies have been proposed during last several decades, few works have been dedicated to systematically analyze and exactly preserve the hydraulic similarity. In the present study, the hydraulic similarity analyses are performed at both system and local level. By this mean, the scaling criteria for the exact hydraulic similarity in a full-pressure model have been sought. In other words, not only the system-level but also the local-level hydraulic similarities are pursued. As the hydraulic characteristics of a fluid system is governed by the momentum equation, the scaling analysis starts with it. A dimensionless integral loop momentum equation is derived to obtain the dimensionless numbers. In the dimensionless momentum equation, two dimensionless numbers, the dimensionless flow resistance number and the dimensionless gravitational force number, are identified along with a unique hydraulic time scale, characterizing the system hydraulic response. A full-height full-pressure model is also made to see which model among the full-height model and reduced-height model can preserve the hydraulic behavior of the prototype. From the dimensionless integral momentum equation, a unique hydraulic time scale, which characterizes the hydraulic response of a single-phase natural circulation system, is identified along with two dimensionless parameters: the dimensionless flow resistance number and the dimensionless gravitational force number. By satisfying the equality of both dimensionless numbers

  11. Effects of feedback reliability on feedback-related brain activity: A feedback valuation account.

    Science.gov (United States)

    Ernst, Benjamin; Steinhauser, Marco

    2018-04-06

    Adaptive decision making relies on learning from feedback. Because feedback sometimes can be misleading, optimal learning requires that knowledge about the feedback's reliability be utilized to adjust feedback processing. Although previous research has shown that feedback reliability indeed influences feedback processing, the underlying mechanisms through which this is accomplished remain unclear. Here we propose that feedback processing is adjusted by the adaptive, top-down valuation of feedback. We assume that unreliable feedback is devalued relative to reliable feedback, thus reducing the reward prediction errors that underlie feedback-related brain activity and learning. A crucial prediction of this account is that the effects of feedback reliability are susceptible to contrast effects. That is, the effects of feedback reliability should be enhanced when both reliable and unreliable feedback are experienced within the same context, as compared to when only one level of feedback reliability is experienced. To evaluate this prediction, we measured the event-related potentials elicited by feedback in two experiments in which feedback reliability was varied either within or between blocks. We found that the fronto-central valence effect, a correlate of reward prediction errors during reinforcement learning, was reduced for unreliable feedback. But this result was obtained only when feedback reliability was varied within blocks, thus indicating a contrast effect. This suggests that the adaptive valuation of feedback is one mechanism underlying the effects of feedback reliability on feedback processing.

  12. Feedback For Helpers

    Science.gov (United States)

    Stromer, Walter F.

    1975-01-01

    The author offers some feedback to those in the helping professions in three areas: (1) forms and letters; (2) jumping to conclusions; and (3) blaming and belittling, in hopes of stimulating more feedback as well as more positive ways of performing their services. (HMV)

  13. 'Peer feedback' voor huisartsopleiders

    NARCIS (Netherlands)

    Damoiseaux, R A M J; Truijens, L

    2016-01-01

    In medical specialist training programmes it is common practice for residents to provide feedback to their medical trainers. The problem is that due to its anonymous nature, the feedback often lacks the specificity necessary to improve the performance of trainers. If anonymity is to be abolished,

  14. Feedback og interpersonel kommunikation

    DEFF Research Database (Denmark)

    Dindler, Camilla

    2016-01-01

    Som interpersonel kommunikationsform handler feedback om at observere, mærke og italesætte det, som handler om relationen mellem samtaleparterne mere end om samtaleemnet. Her er fokus på, hvad der siges og hvordan der kommunikeres sammen. Feedback er her ikke en korrigerende tilbagemelding til...

  15. Status of Digital Orbit Feedback for SPEAR

    International Nuclear Information System (INIS)

    Hettel, Robert

    2003-01-01

    The present global orbit feedback system for SPEAR can adjust the electron beam position with a cycle time of 5 s. In addition, 50 Hz analog local servos stabilize the vertical photon beam position at monitors situated in the ten SSRL beamlines. The global and local systems will soon be merged into a single unified system operating from a dedicated DSP board. The goal is to acquire orbits, process the data, and correct beam position in a 1-2 ms interval to achieve a 30-50 Hz closed-loop bandwidth

  16. VHTR core modeling: coupling between neutronic and thermal-hydraulics

    International Nuclear Information System (INIS)

    Limaiem, I.; Damian, F.; Raepsaet, X.; Studer, E.

    2005-01-01

    Following the present interest in the next generation nuclear power plan (NGNP), Cea is deploying special effort to develop new models and qualify its research tools for this next generation reactors core. In this framework, the Very High Temperature Reactor concept (VHTR) has an increasing place in the actual research program. In such type of core, a strong interaction exists between neutronic and thermal-hydraulics. Consequently, the global core modelling requires accounting for the temperature feedback in the neutronic models. The purpose of this paper is to present the new neutronic and thermal-hydraulics coupling model dedicated to the High Temperature Reactors (HTR). The coupling model integrates a new version of the neutronic scheme calculation developed in collaboration between Cea and Framatome-ANP. The neutronic calculations are performed using a specific calculation processes based on the APOLLO2 transport code and CRONOS2 diffusion code which are part of the French reactor physics code system SAPHYR. The thermal-hydraulics model is characterised by an equivalent porous media and 1-D fluid/3-D thermal model implemented in the CAST3M/ARCTURUS code. The porous media approach involves the definition of both homogenous and heterogeneous models to ensure a correct temperature feedback. This study highlights the sensitivity of the coupling system's parameters (radial/axial meshing and data exchange strategy between neutronic and thermal-hydraulics code). The parameters sensitivity study leads to the definition of an optimal coupling system specification for the VHTR. Besides, this work presents the first physical analysis of the VHTR core in steady-state condition. The analysis gives information about the 3-D power peaking and the temperature coefficient. Indeed, it covers different core configurations with different helium distribution in the core bypass. (authors)

  17. Closing the loop.

    Science.gov (United States)

    Dassau, E; Atlas, E; Phillip, M

    2010-02-01

    The dream of closing the loop is actually the dream of creating an artificial pancreas and freeing the patients from being involved with the care of their own diabetes. Insulin-dependent diabetes (type 1) is a chronic incurable disease which requires constant therapy without the possibility of any 'holidays' or insulin-free days. It means that patients have to inject insulin every day of their life, several times per day, and in order to do it safely they also have to measure their blood glucose levels several times per day. Patients need to plan their meals, their physical activities and their insulin regime - there is only very small room for spontaneous activities. This is why the desire for an artificial pancreas is so strong despite the fact that it will not cure the diabetic patients. Attempts to develop a closed-loop system started in the 1960s but never got to a clinical practical stage of development. In recent years the availability of continuous glucose sensors revived those efforts and stimulated the clinician and researchers to believe that closing the loop might be possible nowadays. Many papers have been published over the years describing several different ideas on how to close the loop. Most of the suggested systems have a sensing arm that measures the blood glucose repeatedly or continuously, an insulin delivery arm that injects insulin upon command and a computer that makes the decisions of when and how much insulin to deliver. The differences between the various published systems in the literature are mainly in their control algorithms. However, there are also differences related to the method and site of glucose measurement and insulin delivery. SC glucose measurements and insulin delivery are the most studied option but other combinations of insulin measurements and glucose delivery including intravascular and intraperitoneal (IP) are explored. We tried to select recent publications that we believe had influenced and inspired people interested

  18. Loop Quantum Cosmology.

    Science.gov (United States)

    Bojowald, Martin

    2008-01-01

    Quantum gravity is expected to be necessary in order to understand situations in which classical general relativity breaks down. In particular in cosmology one has to deal with initial singularities, i.e., the fact that the backward evolution of a classical spacetime inevitably comes to an end after a finite amount of proper time. This presents a breakdown of the classical picture and requires an extended theory for a meaningful description. Since small length scales and high curvatures are involved, quantum effects must play a role. Not only the singularity itself but also the surrounding spacetime is then modified. One particular theory is loop quantum cosmology, an application of loop quantum gravity to homogeneous systems, which removes classical singularities. Its implications can be studied at different levels. The main effects are introduced into effective classical equations, which allow one to avoid the interpretational problems of quantum theory. They give rise to new kinds of early-universe phenomenology with applications to inflation and cyclic models. To resolve classical singularities and to understand the structure of geometry around them, the quantum description is necessary. Classical evolution is then replaced by a difference equation for a wave function, which allows an extension of quantum spacetime beyond classical singularities. One main question is how these homogeneous scenarios are related to full loop quantum gravity, which can be dealt with at the level of distributional symmetric states. Finally, the new structure of spacetime arising in loop quantum gravity and its application to cosmology sheds light on more general issues, such as the nature of time. Supplementary material is available for this article at 10.12942/lrr-2008-4.

  19. Loop Quantum Cosmology

    Directory of Open Access Journals (Sweden)

    Bojowald Martin

    2008-07-01

    Full Text Available Quantum gravity is expected to be necessary in order to understand situations in which classical general relativity breaks down. In particular in cosmology one has to deal with initial singularities, i.e., the fact that the backward evolution of a classical spacetime inevitably comes to an end after a finite amount of proper time. This presents a breakdown of the classical picture and requires an extended theory for a meaningful description. Since small length scales and high curvatures are involved, quantum effects must play a role. Not only the singularity itself but also the surrounding spacetime is then modified. One particular theory is loop quantum cosmology, an application of loop quantum gravity to homogeneous systems, which removes classical singularities. Its implications can be studied at different levels. The main effects are introduced into effective classical equations, which allow one to avoid the interpretational problems of quantum theory. They give rise to new kinds of early-universe phenomenology with applications to inflation and cyclic models. To resolve classical singularities and to understand the structure of geometry around them, the quantum description is necessary. Classical evolution is then replaced by a difference equation for a wave function, which allows an extension of quantum spacetime beyond classical singularities. One main question is how these homogeneous scenarios are related to full loop quantum gravity, which can be dealt with at the level of distributional symmetric states. Finally, the new structure of spacetime arising in loop quantum gravity and its application to cosmology sheds light on more general issues, such as the nature of time.

  20. Loop Quantum Cosmology

    Directory of Open Access Journals (Sweden)

    Bojowald Martin

    2005-12-01

    Full Text Available Quantum gravity is expected to be necessary in order to understand situations where classical general relativity breaks down. In particular in cosmology one has to deal with initial singularities, i.e., the fact that the backward evolution of a classical space-time inevitably comes to an end after a finite amount of proper time. This presents a breakdown of the classical picture and requires an extended theory for a meaningful description. Since small length scales and high curvatures are involved, quantum effects must play a role. Not only the singularity itself but also the surrounding space-time is then modified. One particular realization is loop quantum cosmology, an application of loop quantum gravity to homogeneous systems, which removes classical singularities. Its implications can be studied at different levels. Main effects are introduced into effective classical equations which allow to avoid interpretational problems of quantum theory. They give rise to new kinds of early universe phenomenology with applications to inflation and cyclic models. To resolve classical singularities and to understand the structure of geometry around them, the quantum description is necessary. Classical evolution is then replaced by a difference equation for a wave function which allows to extend space-time beyond classical singularities. One main question is how these homogeneous scenarios are related to full loop quantum gravity, which can be dealt with at the level of distributional symmetric states. Finally, the new structure of space-time arising in loop quantum gravity and its application to cosmology sheds new light on more general issues such as time.