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Sample records for hybrid-arq chase combining

  1. On the performance of hybrid-ARQ with incremental redundancy and with code combining over relay channels

    KAUST Repository

    Chelli, Ali

    2013-08-01

    In this paper, we consider a relay network consisting of a source, a relay, and a destination. The source transmits a message to the destination using hybrid automatic repeat request (HARQ). The relay overhears the transmitted messages over the different HARQ rounds and tries to decode the data packet. In case of successful decoding at the relay, both the relay and the source cooperate to transmit the message to the destination. The channel realizations are independent for different HARQ rounds. We assume that the transmitter has no channel state information (CSI). Under such conditions, power and rate adaptation are not possible. To overcome this problem, HARQ allows the implicit adaptation of the transmission rate to the channel conditions by the use of feedback. There are two major HARQ techniques, namely HARQ with incremental redundancy (IR) and HARQ with code combining (CC). We investigate the performance of HARQ-IR and HARQ-CC over a relay channel from an information theoretic perspective. Analytical expressions are derived for the information outage probability, the average number of transmissions, and the average transmission rate. We illustrate through our investigation the benefit of relaying. We also compare the performance of HARQ-IR and HARQ-CC and show that HARQ-IR outperforms HARQ-CC. © 2013 IEEE.

  2. On the Performance Analysis of Hybrid ARQ With Incremental Redundancy and With Code Combining Over Free-Space Optical Channels With Pointing Errors

    KAUST Repository

    Zedini, Emna; Chelli, Ali; Alouini, Mohamed-Slim

    2014-01-01

    In this paper, we investigate the performance of hybrid automatic repeat request (HARQ) with incremental redundancy (IR) and with code combining (CC) from an information-theoretic perspective over a point-to-point free-space optical (FSO) system. First, we introduce new closed-form expressions for the probability density function, the cumulative distribution function, the moment generating function, and the moments of an FSO link modeled by the Gamma fading channel subject to pointing errors and using intensity modulation with direct detection technique at the receiver. Based on these formulas, we derive exact results for the average bit error rate and the capacity in terms of Meijer's G functions. Moreover, we present asymptotic expressions by utilizing the Meijer's G function expansion and using the moments method, too, for the ergodic capacity approximations. Then, we provide novel analytical expressions for the outage probability, the average number of transmissions, and the average transmission rate for HARQ with IR, assuming a maximum number of rounds for the HARQ protocol. Besides, we offer asymptotic expressions for these results in terms of simple elementary functions. Additionally, we compare the performance of HARQ with IR and HARQ with CC. Our analysis demonstrates that HARQ with IR outperforms HARQ with CC.

  3. On the Performance Analysis of Hybrid ARQ With Incremental Redundancy and With Code Combining Over Free-Space Optical Channels With Pointing Errors

    KAUST Repository

    Zedini, Emna

    2014-07-16

    In this paper, we investigate the performance of hybrid automatic repeat request (HARQ) with incremental redundancy (IR) and with code combining (CC) from an information-theoretic perspective over a point-to-point free-space optical (FSO) system. First, we introduce new closed-form expressions for the probability density function, the cumulative distribution function, the moment generating function, and the moments of an FSO link modeled by the Gamma fading channel subject to pointing errors and using intensity modulation with direct detection technique at the receiver. Based on these formulas, we derive exact results for the average bit error rate and the capacity in terms of Meijer\\'s G functions. Moreover, we present asymptotic expressions by utilizing the Meijer\\'s G function expansion and using the moments method, too, for the ergodic capacity approximations. Then, we provide novel analytical expressions for the outage probability, the average number of transmissions, and the average transmission rate for HARQ with IR, assuming a maximum number of rounds for the HARQ protocol. Besides, we offer asymptotic expressions for these results in terms of simple elementary functions. Additionally, we compare the performance of HARQ with IR and HARQ with CC. Our analysis demonstrates that HARQ with IR outperforms HARQ with CC.

  4. Iterative Relay Scheduling with Hybrid ARQ under Multiple User Equipment (Type II) Relay Environments

    KAUST Repository

    Nam, Sung Sik

    2018-01-09

    In this work, we propose an iterative relay scheduling with hybrid ARQ (IRS-HARQ) scheme which realizes fast jump-in/successive relaying and subframe-based decoding under the multiple user equipment (UE) relay environments applicable to the next-generation cellular systems (e.g., LTE-Advanced and beyond). The proposed IRS-HARQ aims to increase the achievable data rate by iteratively scheduling a relatively better UE relay closer to the end user in a probabilistic sense, provided that the relay-to-end user link should be operated in an open-loop and transparent mode. The latter is due to the fact that not only there are no dedicated control channels between the UE relay and the end user but also a new cell is not created. Under this open-loop and transparent mode, our proposed protocol is implemented by partially exploiting the channel state information based on the overhearing mechanism of ACK/NACK for HARQ. Further, the iterative scheduling enables UE-to-UE direct communication with proximity that offers spatial frequency reuse and energy saving.

  5. Hybrid ARQ Scheme with Autonomous Retransmission for Multicasting in Wireless Sensor Networks.

    Science.gov (United States)

    Jung, Young-Ho; Choi, Jihoon

    2017-02-25

    A new hybrid automatic repeat request (HARQ) scheme for multicast service for wireless sensor networks is proposed in this study. In the proposed algorithm, the HARQ operation is combined with an autonomous retransmission method that ensure a data packet is transmitted irrespective of whether or not the packet is successfully decoded at the receivers. The optimal number of autonomous retransmissions is determined to ensure maximum spectral efficiency, and a practical method that adjusts the number of autonomous retransmissions for realistic conditions is developed. Simulation results show that the proposed method achieves higher spectral efficiency than existing HARQ techniques.

  6. Hybrid ARQ Scheme with Autonomous Retransmission for Multicasting in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Young-Ho Jung

    2017-02-01

    Full Text Available A new hybrid automatic repeat request (HARQ scheme for multicast service for wireless sensor networks is proposed in this study. In the proposed algorithm, the HARQ operation is combined with an autonomous retransmission method that ensure a data packet is transmitted irrespective of whether or not the packet is successfully decoded at the receivers. The optimal number of autonomous retransmissions is determined to ensure maximum spectral efficiency, and a practical method that adjusts the number of autonomous retransmissions for realistic conditions is developed. Simulation results show that the proposed method achieves higher spectral efficiency than existing HARQ techniques.

  7. On the performance of hybrid-ARQ with incremental redundancy and with code combining over relay channels

    KAUST Repository

    Chelli, Ali; Alouini, Mohamed-Slim

    2013-01-01

    assume that the transmitter has no channel state information (CSI). Under such conditions, power and rate adaptation are not possible. To overcome this problem, HARQ allows the implicit adaptation of the transmission rate to the channel conditions

  8. Tornado Chasing.

    Science.gov (United States)

    Faidley, Warren

    1991-01-01

    Presents the rationale and purposes behind the phenomenon known as storm chasing, as well as the contributions that tornado chasers have made to both scientific knowledge and public safety. Provides statistical information on tornado frequencies and locations and contact addresses for storm chasers. (JJK)

  9. On the performance of hybrid ARQ with incremental redundancy over amplify-and-forward dual-hop relay networks

    KAUST Repository

    Hadjtaieb, Amir; Chelli, Ali; Alouini, Mohamed-Slim

    2014-01-01

    overhears the transmitted message, amplifies it using a variable gain amplifier, and then forwards the message to the destination. This latter combines both the source and the relay message and tries to decode the information. In case of decoding failure

  10. On the performance of hybrid ARQ with incremental redundancy over amplify-and-forward dual-hop relay networks

    KAUST Repository

    Hadjtaieb, Amir

    2014-09-01

    In this paper, we consider a three node relay network comprising a source, a relay, and a destination. The source transmits the message to the destination using hybrid automatic repeat request (HARQ) with incremental redundancy (IR). The relay overhears the transmitted message, amplifies it using a variable gain amplifier, and then forwards the message to the destination. This latter combines both the source and the relay message and tries to decode the information. In case of decoding failure, the destination sends a negative acknowledgement. A new replica of the message containing new parity bits is then transmitted in the subsequent HARQ round. This process continues until successful decoding occurs at the destination or a maximum number M of rounds is reached. We study the performance of HARQ-IR over the considered relay channel from an information theoretic perspective. We derive for instance exact expressions and bounds for the information outage probability, the average number of transmissions, and the average transmission rate. The derived exact expressions are validated by Monte Carlo simulations.

  11. PERFORMANCE ANALYSIS OF ARQ AND HYBRID ARQ OVER SINGLE-HOP, DUAL-HOP, AND MULTIBRANCH DUAL-HOP NETWORKS

    KAUST Repository

    Hadjtaieb, Amir

    2014-05-01

    During the last decade, relay networks have attracted a lot of interest due to their numerous benefits. The relaying technique allows extending the coverage zone of wireless networks and offers a higher reliability for communication systems. The performance of relay networks can be improved further by the use of automatic repeat request (ARQ) and hybrid automatic repeat request (HARQ) techniques. ARQ and HARQ are retransmission mechanisms that ensure a good quality of service even in absence of channel state information at the transmitter. We, firstly, study the spectral and energy efficiency of ARQ in Nakagami-m block-fading channels. We maximize both spectral efficiency and energy efficiency with respect to the transmitted power. We derive exact expressions as well as compact and tight approximation for the solutions of these problems. Our analysis shows that the two problems of maximizing spectral efficiency and energy efficiency with respect to the transmitted power are completely different and give different solutions. Additionally, operating with a power that maximizes energy efficiency can lead to a significant drop in the spectral efficiency, and vice versa. Next, we consider a three node relay network comprising a source, a relay, and a destination. The source transmits the message to the destination using HARQ with incremental redundancy (IR). The relay overhears the transmitted message, amplifies it using a variable gain amplifier, and then forwards the message to the destination. This latter combines both the source and the relay message and tries to decode the information. In case of decoding failure, the destination sends a negative acknowledgement. A new replica of the message containing new parity bits is then transmitted in the subsequent HARQ round. This process continues until successful decoding occurs at the destination or a maximum number M of rounds is reached. We study the performance of HARQ-IR over the considered relay channel from an

  12. Enhanced performance hybrid-arq

    KAUST Repository

    Fareed, Muhammad Mehboob

    2016-06-16

    Apparatuses, computer readable media, and methods are provided for enhancing hybrid automatic repeat request (ARQ) performance. In an example method, a communication device transmits a first element of a vector, where the vector is selected using the information bits to be transmitted as an index in a code book. In some embodiments, this code book is constructed using Linear Constellation Precoding (LCP). If a NACK is received, the communication device transmits a second element of the vector. The process of transmitting elements of the vector continues until an ACK is received or the maximum number of transmission attempts is reached. If an ACK is received, the communication device transmits a first element of another vector of the code book that encodes a second set of information bits. This procedure may continue until all information bits have been transmitted successfully.

  13. Enhanced performance hybrid-arq

    KAUST Repository

    Fareed, Muhammad Mehboob; Yang, Hong-Chuan; Alouini, Mohamed-Slim

    2016-01-01

    Apparatuses, computer readable media, and methods are provided for enhancing hybrid automatic repeat request (ARQ) performance. In an example method, a communication device transmits a first element of a vector, where the vector is selected using the information bits to be transmitted as an index in a code book. In some embodiments, this code book is constructed using Linear Constellation Precoding (LCP). If a NACK is received, the communication device transmits a second element of the vector. The process of transmitting elements of the vector continues until an ACK is received or the maximum number of transmission attempts is reached. If an ACK is received, the communication device transmits a first element of another vector of the code book that encodes a second set of information bits. This procedure may continue until all information bits have been transmitted successfully.

  14. Tumor-specific detection of an optically targeted antibody combined with a quencher-conjugated neutravidin "quencher-chaser": a dual "quench and chase" strategy to improve target to nontarget ratios for molecular imaging of cancer.

    Science.gov (United States)

    Ogawa, Mikako; Kosaka, Nobuyuki; Choyke, Peter L; Kobayashi, Hisataka

    2009-01-01

    In vivo molecular cancer imaging with monoclonal antibodies has great potential not only for cancer detection, but also for cancer characterization. However, the prolonged retention of intravenously injected antibody in the blood causes low target tumor-to-background ratio (TBR). Avidin has been used as a "chase" to clear the unbound, circulating biotinylated antibody and decrease the background signal. Here, we utilize a combined approach of a fluorescence resonance energy transfer (FRET) quenched antibody with an "avidin chase" to increase TBR. Trastuzumab, a humanized monoclonal antibody against human epidermal growth factor receptor type 2 (HER2), was biotinylated and conjugated with the near-infrared (NIR) fluorophore Alexa680 to synthesize Tra-Alexa680-biotin. Next, the FRET quencher, QSY-21, was conjugated to avidin, neutravidin (nAv), or streptavidin (sAv), thus creating Av-QSY21, nAv-QSY21, or sAv-QSY21 as "chasers". The fluorescence was quenched in vitro by binding Tra-Alexa680-biotin to Av-QSY21, nAv-QSY21, or sAv-QSY21. To evaluate if the injection of quencher-conjugated avidin derivatives can improve target TBR by using a dual "quench and chase" strategy, both target (3T3/HER2+) and nontarget (Balb3T3/ZsGreen) tumor-bearing mice were employed. The "FRET quench" effect induced by all the QSY21 avidin-based conjugates reduced but did not totally eliminate background signal from the blood pool. The addition of nAv-QSY21 administration increased target TBR mainly because of the "chase" effect where unbound conjugated antibody was preferentially cleared to the liver. The relatively slow clearance of unbound nAv-QSY21 leads to further reductions in background signal by leaking out of the vascular space and binding to unbound antibodies in the extravascular space of tumors, resulting in decreased nontarget tumor-to-background ratios but increased target TBR due to the "FRET quench" effect, because target-bound antibodies were internalized and could not bind

  15. Chasing Ecological Interactions.

    Science.gov (United States)

    Jordano, Pedro

    2016-09-01

    Basic research on biodiversity has concentrated on individual species-naming new species, studying distribution patterns, and analyzing their evolutionary relationships. Yet biodiversity is more than a collection of individual species; it is the combination of biological entities and processes that support life on Earth. To understand biodiversity we must catalog it, but we must also assess the ways species interact with other species to provide functional support for the Tree of Life. Ecological interactions may be lost well before the species involved in those interactions go extinct; their ecological functions disappear even though they remain. Here, I address the challenges in studying the functional aspects of species interactions and how basic research is helping us address the fast-paced extinction of species due to human activities.

  16. Chasing viruses feverishly

    Directory of Open Access Journals (Sweden)

    Chandrakant Lahariya

    2017-01-01

    Full Text Available A number of viral diseases have emerged and re-emerged in India and globally, in the last few years. Effective prevention and control of these diseases require, in addition to a functioning disease surveillance system, interventions both before and after disease occurrence, and a combination of personal and population services. However, the current efforts to control emerging viral diseases in India has major therapeutic focus (and attention on diagnostic and curative services and there is limited attention on preventive and promotive components. It is proposed that for an effective and successful control, a systematic approach is adopted with an appropriate selection of personal and population health services, delivered by government through participation of private sector. This is possible through commitment and leadership of Government and other public health agencies, supplemented by multi agency coordination, sufficient funding and an accountability mechanism.

  17. Loss-Chasing, Alexithymia and Impulsivity: Alexithymia as a precursor to loss-chasing when gambling.

    Directory of Open Access Journals (Sweden)

    Peter Anthony Bibby

    2016-01-01

    Full Text Available Objective: To examine the relationship between loss-chasing, the propensity to continue gambling to recover from losses, alexithymia, a personality trait associated poor emotional processing and impulsivity, the tendency to act quickly without reflection or consideration of the consequences.Method: Two experiments are reported (E1: N=60, Males, 11; Age, 21.6 years. E2: N=49, Males, 22; Age, 21.1 years. In experiment 1, two groups (low alexithymia, high alexithymia completed the Cambridge Gambling Task. Loss-chasing behaviour was investigated. In experiment 2, both alexithymia (low, high and impulsivity (low, high were examined also using the CGT. A further change was the order of bet proportion from ascending to descending. Results: Experiment 1 shows loss-chasing behaviour in participants high in alexithymia but not those low in alexithymia (η_p^2=.09. Experiment 2 shows loss-chasing behaviour in participants both low and high in alexithymia but it was greater for participants high in alexithymia (η_p^2=.09. The effect of impulsivity was not statistically significant (η_p^2=.01. Loss-chasing behaviour was correlated with the emotional facets of alexithymia but not the cognitive facet. Conclusions: Alexithymia is a precursor to loss-chasing when gambling and loss-chasing reflects the cognitive and emotional aspects of gambling. Specifically, the tendency to loss-chase depends on the need to recoup previous losses and failure to process the emotional consequences of those losses.

  18. Fox Chase Network: Fox Chase Cancer Center's community hospital affiliation program.

    Science.gov (United States)

    Higman, S A; McKay, F J; Engstrom, P F; O'Grady, M A; Young, R C

    2000-01-01

    Fox Chase Cancer Center developed a format for affiliation with community providers in 1986. Fox Chase Network was formed to establish hospital-based community cancer centers to increase access to patients involved in clinical research. Under this program, the Fox Chase Network now contributes 500 patients per year to prevention and clinical research studies. As relationships with community providers form, patient referrals have increased at Fox Chase Cancer Center and for each Fox Chase Network member. A dedicated staff is required to operate the central office on a day-to-day basis as well as at each affiliate. We have found this to be a critical element in each program's success. New challenges in the cancer business-increasing volumes with declining revenue-have caused us to reconfigure the services offered to affiliates, while maintaining true to our mission: to reduce the burden of human cancer.

  19. Chinese Learning Journeys: Chasing the Dream

    Science.gov (United States)

    Su, Feng, Ed.

    2011-01-01

    Eight students from mainland China chart their learning journeys across national and continental boundaries and socio-cultural contexts. The five women and three men structure their experiences of studying in China and the West around the turning points and life changing choices they made in chasing their dreams. They embody its emergent…

  20. Pattern production through a chiral chasing mechanism

    Science.gov (United States)

    Woolley, Thomas E.

    2017-09-01

    Recent experiments on zebrafish pigmentation suggests that their typical black and white striped skin pattern is made up of a number of interacting chromatophore families. Specifically, two of these cell families have been shown to interact through a nonlocal chasing mechanism, which has previously been modeled using integro-differential equations. We extend this framework to include the experimentally observed fact that the cells often exhibit chiral movement, in that the cells chase, and run away, at angles different to the line connecting their centers. This framework is simplified through the use of multiple small limits leading to a coupled set of partial differential equations which are amenable to Fourier analysis. This analysis results in the production of dispersion relations and necessary conditions for a patterning instability to occur. Beyond the theoretical development and the production of new pattern planiforms we are able to corroborate the experimental hypothesis that the global pigmentation patterns can be dependent on the chirality of the chromatophores.

  1. Paper Chase and the Socratic Method of Teaching Law.

    Science.gov (United States)

    Dillon, J. T.

    1980-01-01

    It is argued that the Socratic method of teaching law as depicted in the book, movie, and TV series "Paper Chase" is not really the Socratic method at all. The genuine Socratic method and the questioning technique used in "Paper Chase" are examined and their appropriateness and effectiveness as methods for teaching contract law…

  2. Chasing behaviour and optomotor following in free-flying male blowflies: flight performance and interactions of the underlying control systems

    Directory of Open Access Journals (Sweden)

    Christine Trischler

    2010-05-01

    Full Text Available The chasing behaviour of male blowflies after small targets belongs to the most rapid and virtuosic visually guided behaviours found in nature. Since in a structured environment any turn towards a target inevitably leads to a displacement of the entire retinal image in the opposite direction, it might evoke optomotor following responses counteracting the turn. To analyse potential interactions between the control systems underlying chasing behaviour and optomotor following, respectively, we performed behavioural experiments on male blowflies and examined the characteristics of the two flight control systems in isolation and in combination. Three findings are particularly striking. (i The characteristic saccadic flight and gaze style – a distinctive feature of blowfly cruising flights – is largely abandoned when the entire visual surroundings move around the fly; in this case flies tend to follow the moving pattern in a relatively continuous and smooth way. (ii When male flies engage in following a small target, they also employ a smooth pursuit strategy. (iii Although blowflies are reluctant to fly at high background velocities, the performance and dynamical characteristics of the chasing system are not much affected when the background moves in either the same or in the opposite direction as the target. Hence, the optomotor following response is largely suppressed by the chasing system and does not much impair chasing performance.

  3. Toxic leucoencephalopathy after 'chasing the dragon'.

    Science.gov (United States)

    Singh, Rajinder; Saini, Monica

    2015-06-01

    Toxic leucoencephalopathy (TLE) is a rare neurological complication of heroin abuse. 'Chasing the dragon' is an inhalational mode of heroin abuse that originated in Southeast Asia. Intriguingly, no cases of TLE have been reported from this region, although the inhalational mode of heroin abuse is common. We herein report the case of a middle-aged man with a history of polysubstance abuse who presented with progressive neurological symptoms and progressed to an uncommunicative state. While the initial impression was that of iatrogenic parkinsonism, diffuse leucoencephalopathy with sparing of the cerebellum was noted on magnetic resonance imaging. In view of his history of inhalational heroin abuse close to the onset of the neurological symptoms, a diagnosis of TLE was made. No clinical improvement was noted with administration of a dopaminergic agent. This is the first known case of delayed TLE following heroin inhalation from Southeast Asia with the unusual feature of cerebellar sparing.

  4. Chases and escapes the mathematics of pursuit and evasion

    CERN Document Server

    Nahin, Paul J

    2012-01-01

    We all played tag when we were kids. What most of us don't realize is that this simple chase game is in fact an application of pursuit theory, and that the same principles of games like tag, dodgeball, and hide-and-seek are also at play in military strategy, high-seas chases by the Coast Guard, and even romantic pursuits. In Chases and Escapes, Paul Nahin gives us the first complete history of this fascinating area of mathematics, from its classical analytical beginnings to the present day. Drawing on game theory, geometry, linear algebra, target-tracking algorithms, and much

  5. Establishment of the Fox Chase Network Breast Cancer Risk Registry

    National Research Council Canada - National Science Library

    Daly, Mary

    1997-01-01

    .... The development of the Fox Chase Cancer Center Breast Cancer Risk Registry was proposed to facilitate research in the epidemiologic and genetic predictors of disease and will permit evaluation...

  6. SWFSC/MMTD/ETP: Chase Encirclement Stress Studies (CHESS) 2001

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The CHase Encirclement Stress Studies (CHESS) are part of a comprehensive research program designed to investigate the status of dolphin stocks that are involved in...

  7. Episodic chasing in pathological gamblers using the Iowa gambling task

    DEFF Research Database (Denmark)

    Linnet, J.; Rojskjaer, S.; Nygaard, Jørgen

    2006-01-01

    NPGs on the Iowa Gambling Task (IGT) and the Zuckerman Sensation Seeking Scale (SSS). The PGs showed significantly more chasing and had significantly poorer decision-making strategies than NPGs, particularly among males (F = 4.52, p

  8. Knowing When to Stop: The Brain Mechanisms of Chasing Losses

    DEFF Research Database (Denmark)

    Campbell-Meiklejohn, Daniel; Woolrich, Mark; Passingham, Dick

    2008-01-01

    adult participants decided to chase losses or decided to quit gambling to prevent further losses.ResultsChasing losses was associated with increased activity in cortical areas linked to incentive-motivation and an expectation of reward. By contrast, quitting was associated with decreased activity...... in pathological gambling might involve a failure to appropriately balance activity within neural systems coding conflicting motivational states. Similar mechanisms might underlie the loss-of-control over appetitive behaviors in other impulse control disorders....

  9. The CHASE laboratory search for chameleon dark energy

    International Nuclear Information System (INIS)

    Steffen, Jason H.

    2010-01-01

    A scalar field is a favorite candidate for the particle responsible for dark energy. However, few theoretical means exist that can simultaneously explain the observed acceleration of the Universe and evade tests of gravity. The chameleon mechanism, whereby the properties of a particle depend upon the local environment, is one possible avenue. We present the results of the Chameleon Afterglow Search (CHASE) experiment, a laboratory probe for chameleon dark energy. CHASE marks a significant improvement other searches for chameleons both in terms of its sensitivity to the photon/chameleon coupling as well as its sensitivity to the classes of chameleon dark energy models and standard power-law models. Since chameleon dark energy is virtually indistinguishable from a cosmological constant, CHASE tests dark energy models in a manner not accessible to astronomical surveys.

  10. The CHASE laboratory search for chameleon dark energy

    Energy Technology Data Exchange (ETDEWEB)

    Steffen, Jason [Fermi National Accelerator Laboratory - Fermilab, P.O. Box 500, Batavia, IL 60510-5011 (United States)

    2010-07-01

    A scalar field is a favorite candidate for the particle responsible for dark energy. However, few theoretical means exist that can simultaneously explain the observed acceleration of the Universe and evade tests of gravity. The chameleon mechanism, whereby the properties of a particle depend upon the local environment, is one possible avenue. I present the results of the Chameleon Afterglow Search (CHASE) experiment, a laboratory probe for chameleon dark energy. CHASE marks a significant improvement over other searches for chameleons both in terms of its sensitivity to the photon/chameleon coupling as well as its sensitivity to the classes of chameleon dark energy models and standard power-law models. Since chameleon dark energy is virtually indistinguishable from a cosmological constant, CHASE tests dark energy models in a manner not accessible to astronomical surveys. (author)

  11. 75 FR 31510 - Fox Chase Bancorp, Inc., Hatboro, PA; Approval of Conversion

    Science.gov (United States)

    2010-06-03

    ... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-43: OTS No. H-4707] Fox Chase Bancorp, Inc., Hatboro, PA; Approval of Conversion Application Notice is hereby given that on May 14, 2010, the Office of Thrift Supervision approved the application of Fox Chase MHC and Fox Chase Bank, Hatboro...

  12. An application of importance-performance analysis to recreational storm chasing

    Science.gov (United States)

    Jiawen Chen; Sonja Wilhelm Stanis; Carla Barbieri; Shuangyu. Xu

    2012-01-01

    Since the release of the movie "Twister" in 1996, storm chasing has become an increasingly popular form of recreation. Storm chasing tour agencies have emerged to provide technical assistance and guidance to individuals wishing to participate in this activity. However, little is known about the participants' perceptions of their storm chasing tours....

  13. Chasing as a model of psychogenic stress: characterization of physiological and behavioral responses.

    Science.gov (United States)

    Lee, Ji-Hye; Kimm, Sunwhi; Han, Jung-Soo; Choi, June-Seek

    2018-03-25

    Being chased by a predator or a dominant conspecific can induce significant stress. However, only a limited number of laboratory studies have employed chasing by itself as a stressor. In this study, we developed a novel stress paradigm in which rats were chased by a fast-moving object in an inescapable maze. In Experiment 1, defensive behaviors and stress hormone changes induced by chasing stress were measured. During the chasing stress, the chasing-stress group (n = 9) froze and emitted 22-kHz ultrasonic vocalizations (USVs), but the no-chasing control group (n = 10) did not. Plasma corticosterone levels significantly increased following the chasing and were comparable to those of the restraint-stress group (n = 6). In Experiment 2, the long-lasting memory of the chasing event was tested after three weeks. The chasing-stress group (n = 15) showed higher levels of freezing and USV than the no-chasing group (n = 14) when they were presented with the tone associated with the object's chasing action. Subsequently, the rats were subjected to Pavlovian threat conditioning with a tone as a conditioned stimulus and footshock as an unconditioned stimulus. The chasing-stress group showed higher levels of freezing and USV during the conditioning session than the no-chasing group, indicating sensitized defensive reactions in a different threat situation. Taken together, the current results suggest that chasing stress can induce long-lasting memory and sensitization of defensive responses to a new aversive event as well as immediate, significant stress responses.

  14. Cooperative and Human Aspects of Software Engineering (CHASE 2008)

    DEFF Research Database (Denmark)

    2008-01-01

    ethnographic research to experiments. Moreover, the background of attendees reflects the diversity of researchers in this domain, ranging from sociology to psychology, from informatics to software engineering. CHASE 1008 met its goals in presenting high-quality research and building community through a mixture...... of presentations, discussions, posters, and social activities....

  15. Volatilisation of diacetylmorphine: in vitro simulation of 'chasing the dragon'

    NARCIS (Netherlands)

    Klous, M. G.; Lee, W. C.; van den Brink, W.; van Ree, J. M.; Beijnen, J. H.

    2006-01-01

    In preparation for a trial on co-prescription of heroin to chronic treatment-resistant addicts, a pharmaceutical dosage form for smokable heroin was developed. During development of this product (a mixture of diacetylmorphine and caffeine), in vitro experiments were performed simulating 'chasing the

  16. Cryptic sexual conflict in gift-giving insects: chasing the chase-away.

    Science.gov (United States)

    Sakaluk, Scott K; Avery, Rachel L; Weddle, Carie B

    2006-01-01

    The chase-away model of sexual selection posits that elaborate male sexual displays arise because they exploit preexisting biases in females' sensory systems and induce females to mate in a suboptimal manner. An essential element of this hypothesis is that such manipulation should quickly lead to female resistance to male displays. Nuptial food gifts may be a frequent conduit by which males attempt to influence the mating behavior of females against females' own reproductive interests. In decorated crickets Gryllodes sigillatus, such inducements come in the form of a spermatophylax, a gelatinous mass forming part of the male's spermatophore and consumed by the female after mating. We conducted experiments in which spermatophylaxes obtained from male G. sigillatus were offered as novel food gifts to females of a non-gift-giving species (Acheta domesticus) having no evolutionary history of spermatophylax consumption. Female A. domesticus that were allowed to consume the spermatophylax took significantly longer to remate than when given no such opportunity. In contrast, when female G. sigillatus were prevented from consuming their partners' nuptial gifts, there was no difference in their propensity to remate relative to females permitted to consume a food gift after mating. These results suggest that the spermatophylax synthesized by male G. sigillatus contains substances designed to inhibit the sexual receptivity of their mates but that female G. sigillatus have evolved reduced responsiveness to these substances.

  17. On the Performance of RF-FSO Links with and without Hybrid ARQ

    KAUST Repository

    Makki, Behrooz; Svensson, Tommy; Eriksson, Thomas; Alouini, Mohamed-Slim

    2016-01-01

    This paper studies the performance of hybrid radiofrequency (RF) and free-space optical (FSO) links assuming perfect channel state information (CSI) at the receiver. Considering the cases with and without hybrid automatic repeat request (HARQ), we

  18. Performance and delay analysis of hybrid ARQ with incremental redundancy over double rayleigh fading channels

    KAUST Repository

    Chelli, Ali; Zedini, Emna; Alouini, Mohamed-Slim; Barry, John R.; Pä tzold, Matthias

    2014-01-01

    the performance of HARQ from an information theoretic perspective. Analytical expressions are derived for the \\epsilon-outage capacity, the average number of transmissions, and the average transmission rate of HARQ with incremental redundancy assuming a maximum

  19. Performance and delay analysis of hybrid ARQ with incremental redundancy over double rayleigh fading channels

    KAUST Repository

    Chelli, Ali

    2014-11-01

    In this paper, we study the performance of hybrid automatic repeat request (HARQ) with incremental redundancy over double Rayleigh channels, a common model for the fading amplitude of vehicle-to-vehicle communication systems. We investigate the performance of HARQ from an information theoretic perspective. Analytical expressions are derived for the \\\\epsilon-outage capacity, the average number of transmissions, and the average transmission rate of HARQ with incremental redundancy assuming a maximum number of HARQ rounds. Moreover, we evaluate the delay experienced by Poisson arriving packets for HARQ with incremental redundancy. We provide analytical expressions for the expected waiting time, the packet\\'s sojourn time in the queue, the average consumed power, and the energy efficiency. In our study, the communication rate per HARQ round is adjusted to the average signal-to-noise ratio (SNR) such that a target outage probability is not exceeded. This setting conforms with communication systems in which a quality of service is expected regardless of the channel conditions. Our analysis underscores the importance of HARQ in improving the spectral efficiency and reliability of communication systems. We demonstrate as well that the explored HARQ scheme achieves full diversity. Additionally, we investigate the tradeoff between energy efficiency and spectral efficiency.

  20. Unified performance analysis of hybrid-ARQ with incremental redundancy over free-space optical channels

    KAUST Repository

    Zedini, Emna

    2014-09-01

    In this paper, we carry out a unified performance analysis of hybrid automatic repeat request (HARQ) with incremental redundancy (IR) from an information theoretic perspective over a point-to-point free-space optical (FSO) system. First, we introduce a novel unified expression for the distribution of a single FSO link modeled by the Gamma fading that accounts for pointing errors subject to both types of detection techniques at the receiver side (i.e. heterodyne detection and intensity modulation with direct detection (IM/DD)). Then, we provide analytical expressions for the outage probability, the average number of transmissions, and the average transmission rate for HARQ with IR, assuming a maximum number of rounds for the HARQ protocol. In our study, the communication rate per HARQ round is constant. Our analysis demonstrates the importance of HARQ in improving the performance and reliability of FSO communication systems. All the given results are verified via computer-based Monte-Carlo simulations.

  1. On the Performance of RF-FSO Links with and without Hybrid ARQ

    KAUST Repository

    Makki, Behrooz

    2016-04-01

    This paper studies the performance of hybrid radiofrequency (RF) and free-space optical (FSO) links assuming perfect channel state information (CSI) at the receiver. Considering the cases with and without hybrid automatic repeat request (HARQ), we derive closed-form expressions for the message decoding probabilities as well as the throughput and the outage probability of the RF-FSO setups. We also evaluate the effect of adaptive power allocation and different channel conditions on the throughput and the outage probability. The results show the efficiency of the RF-FSO links in different conditions.

  2. Performance of hybrid-ARQ with incremental redundancy over relay channels

    KAUST Repository

    Chelli, Ali; Alouini, Mohamed-Slim

    2012-01-01

    In this paper, we consider a relay network consisting of a source, a relay, and a destination. The source transmits a message to the destination using hybrid automatic repeat request (HARQ) with incremental redundancy (IR). The relay overhears

  3. Performance of hybrid-ARQ with incremental redundancy over relay channels

    KAUST Repository

    Chelli, Ali

    2012-12-01

    In this paper, we consider a relay network consisting of a source, a relay, and a destination. The source transmits a message to the destination using hybrid automatic repeat request (HARQ) with incremental redundancy (IR). The relay overhears the transmitted messages over the different HARQ rounds and tries to decode the data packet. In case of successful decoding at the relay, both the relay and the source cooperate to transmit the message to the destination. A maximum number M of HARQ rounds is considered. The channel realizations are independent for different HARQ rounds. We assume Rayleigh fading channels for the links source-relay, source-destination, and relay-destination. We investigate the performance of HARQ-IR over relay channel from an information theoretic perspective. Analytical expressions are derived for the information outage probability, the average number of transmissions, and the average transmission rate. We illustrate through our investigation the benefit of relaying. We also show the impact of the target outage probability and the maximum number M of HARQ rounds on the outage probability, the average number of transmissions, and the average transmission rate. © 2012 IEEE.

  4. Iterative Relay Scheduling with Hybrid ARQ under Multiple User Equipment (Type II) Relay Environments

    KAUST Repository

    Nam, Sung Sik; Alouini, Mohamed-Slim; Choi, Seyeong

    2018-01-01

    -generation cellular systems (e.g., LTE-Advanced and beyond). The proposed IRS-HARQ aims to increase the achievable data rate by iteratively scheduling a relatively better UE relay closer to the end user in a probabilistic sense, provided that the relay-to-end user

  5. Unified performance analysis of hybrid-ARQ with incremental redundancy over free-space optical channels

    KAUST Repository

    Zedini, Emna; Chelli, Ali; Alouini, Mohamed-Slim

    2014-01-01

    In this paper, we carry out a unified performance analysis of hybrid automatic repeat request (HARQ) with incremental redundancy (IR) from an information theoretic perspective over a point-to-point free-space optical (FSO) system. First, we

  6. Improving Link Robustness in 5G Ultra-Dense Small Cells by Hybrid ARQ

    DEFF Research Database (Denmark)

    Gatnau, Marta; Catania, Davide; Frederiksen, Frank

    2014-01-01

    A new 5th generation (5G) radio access technology is expected to cope with an estimated factor of x1000 growth in mobile data traffic in the upcoming years. Such system will be optimized for a massive uncoordinated deployment of small cells, where autonomous operation of the individual nodes may...... bring unpredictable and fast varying link quality. In this paper, Hybrid Automatic Repeat Request (HARQ) is studied as a solution to cope with such unpredictability. An operational mode of HARQ for our 5G system definition is proposed, and its performance is evaluated for two different scheduling...

  7. Chasing Science at Sea: Racing Hurricanes, Stalking Sharks, and Living Undersea With Ocean Experts

    Science.gov (United States)

    Lee, Cindy

    2008-12-01

    Ellen Prager's new book, Chasing Science at Sea, is a personal account of why fieldwork is so important in many areas of ocean science, and how exciting that fieldwork can be. Prager has interwoven her own story of studying carbonates at the interface between biology and geology with stories from friends and colleagues. Storm stories and up-close-and-personal encounters with ocean creatures such as reef squid, marine iguanas, and whales abound. Throughout the book, she emphasizes the idea that the combination of observations and serendipity plays a critical role in science, and she gives examples of where this combination has led to especially important discoveries (e.g., that of hydrothermal vent organisms).

  8. The illusion of handy wins: Problem gambling, chasing, and affective decision-making.

    Science.gov (United States)

    Nigro, Giovanna; Ciccarelli, Maria; Cosenza, Marina

    2018-01-01

    Chasing losses is a behavioral marker and a diagnostic criterion for gambling disorder. It consists in continuing gambling to recoup previous losses. Although chasing has been recognized playing a central role in gambling disorder, research on this topic is relatively scarce, and it remains unclear whether chasing affects decision-making in behavioral tasks in which participants gain or loss some money. Even if several studies found that the more the gambling involvement, the poorer the decision-making, to date no research investigated the role of chasing in decision-making. The study aimed to first investigate the relation between chasing and decision-making in adult gamblers. One hundred and four VLT players were administered the South Oaks Gambling Screen (SOGS), a computerized task measuring chasing, and the Iowa Gambling Task (IGT). Correlation analysis showed that the higher the SOGS scores, the higher the propensity to chase, and the poorer the decision-making performance. Regression analysis revealed that chasing propensity and gambling severity predicted IGT performance. Mediation analysis indicated that the association between gambling severity and poor decision-making is mediated by chasing. Gambling severity was assessed by means of a self-report measure. The generalizability of findings is limited, since the study focused only on VLT players. This study provides the first evidence that chasing, along with gambling severity, affects decision-making, at least in behavioral tasks involving money. Since chasers and non-chasers could be two different sub-types of gamblers, treatment protocols should take into account the additive role of chasing in gambling disorder. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. 78 FR 69663 - Jonathan and Jayne Chase Troy Mills Hydroelectric Inc.; Notice of Transfer of Exemption

    Science.gov (United States)

    2013-11-20

    ... Jayne Chase Troy Mills Hydroelectric Inc.; Notice of Transfer of Exemption 1. By letter filed October 15, 2013, Jonathan Chase informed the Commission that the exemption from licensing for the Troy Hydroelectric Project, FERC No. 13381, originally issued December 2, 2011,\\1\\ has been transferred to Troy Mills...

  10. Significance chasing in research practice: causes, consequences and possible solutions.

    Science.gov (United States)

    Ware, Jennifer J; Munafò, Marcus R

    2015-01-01

    The low reproducibility of findings within the scientific literature is a growing concern. This may be due to many findings being false positives which, in turn, can misdirect research effort and waste money. We review factors that may contribute to poor study reproducibility and an excess of 'significant' findings within the published literature. Specifically, we consider the influence of current incentive structures and the impact of these on research practices. The prevalence of false positives within the literature may be attributable to a number of questionable research practices, ranging from the relatively innocent and minor (e.g. unplanned post-hoc tests) to the calculated and serious (e.g. fabrication of data). These practices may be driven by current incentive structures (e.g. pressure to publish), alongside the preferential emphasis placed by journals on novelty over veracity. There are a number of potential solutions to poor reproducibility, such as new publishing formats that emphasize the research question and study design, rather than the results obtained. This has the potential to minimize significance chasing and non-publication of null findings. Significance chasing, questionable research practices and poor study reproducibility are the unfortunate consequence of a 'publish or perish' culture and a preference among journals for novel findings. It is likely that top-down change implemented by those with the ability to modify current incentive structure (e.g. funders and journals) will be required to address problems of poor reproducibility. © 2014 Society for the Study of Addiction.

  11. What are the underlying units of perceived animacy? Chasing detection is intrinsically object-based.

    Science.gov (United States)

    van Buren, Benjamin; Gao, Tao; Scholl, Brian J

    2017-10-01

    One of the most foundational questions that can be asked about any visual process is the nature of the underlying 'units' over which it operates (e.g., features, objects, or spatial regions). Here we address this question-for the first time, to our knowledge-in the context of the perception of animacy. Even simple geometric shapes appear animate when they move in certain ways. Do such percepts arise whenever any visual feature moves appropriately, or do they require that the relevant features first be individuated as discrete objects? Observers viewed displays in which one disc (the "wolf") chased another (the "sheep") among several moving distractor discs. Critically, two pairs of discs were also connected by visible lines. In the Unconnected condition, both lines connected pairs of distractors; but in the Connected condition, one connected the wolf to a distractor, and the other connected the sheep to a different distractor. Observers in the Connected condition were much less likely to describe such displays using mental state terms. Furthermore, signal detection analyses were used to explore the objective ability to discriminate chasing displays from inanimate control displays in which the wolf moved toward the sheep's mirror-image. Chasing detection was severely impaired on Connected trials: observers could readily detect an object chasing another object, but not a line-end chasing another line-end, a line-end chasing an object, or an object chasing a line-end. We conclude that the underlying units of perceived animacy are discrete visual objects.

  12. Child and adolescent service experience (ChASE): measuring service quality and therapeutic process.

    Science.gov (United States)

    Day, Crispin; Michelson, Daniel; Hassan, Imren

    2011-11-01

    OBJECTIVES. Dissatisfaction with services has been associated with poorer child mental health outcomes, early treatment termination as well as disagreements over the nature of mental health difficulties, reasons for referral and therapy goals. The development of straightforward, reliable, and accurate methods of eliciting service users' views is essential within child and adolescent mental health care. This paper describes the development of the child and adolescent service experience (ChASE), a tool to measure children and young people's service experience DESIGN. The study comprises a non-experimental, cross-sectional design. METHODS. Participants were 132 mental health service users aged 8-18 years. Participants and their main carer completed the ChASE, Parent Satisfaction Questionnaire (PSQ) (Stallard, 1996) and Strengths and Difficulties (SDQ) Impact Supplement. Clinicians completed the SDQ Impact Supplement and provided clinical activity data. A sub-sample of participants completed the ChASE on a second occasion, 6 weeks after the completion of the first questionnaire. RESULTS. Scrutiny of ChASE data indicated high levels of completion. Principal axis factoring identified three factors within the ChASE: Relationship, Privacy, and Session Activity. The ChASE has good internal consistency and test-retest reliability. Significant correlations were found between the ChASE and carer satisfaction, service use, and youth clinical outcomes. CONCLUSIONS. The ChASE is a short, psychometrically robust tool for routine measurement of children, and young people's experience of mental health services, which users can complete easily. The results underline the importance of alliance factors to children and young people and their association with clinical improvement as well as the potential for the ChASE to be used a measure of children's therapeutic progress and alliance. ©2011 The British Psychological Society.

  13. The CHilean Automatic Supernova sEarch (CHASE)

    Science.gov (United States)

    Pignata, G.; Maza, J.; Hamuy, M.; Antezana, R.; Gonzales, L.

    2009-05-01

    One of the most important challenges in modern cosmology will be to figure out the origin of the dark energy, to measure its equation of state and the time rate with which it changes (described by parameters w and w'). The measurement of these parameters will require high levels of accuracy in the Supernova (SN) Type Ia distances and various sources of systematic error such as reddening corrections and possible evolution in the SNcharacteristics which could couple with redshift and mimic the cosmological signal of interest. Fortunately, these concerns can be fully addressed through the comprehensive study of SNe in the local (z < 0.05) universe. Although Type II plateau SNe are not as luminous as SNe Ia, they afford two important, independent routes to cosmological distances using the Expanding Photosphere Method and the Standardized Candle Method. To assess the performance of these techniques a nearby sample of Type II SNe is necessary. With the purpose of addressing these issues the Millennium Center for Supernova Studies (MCSS) is teaming up with the Carnegie Supernova Project (CSP) to carry out an optical and near infrared (photometry, spectroscopy and polarimetry) follow up of nearby SNe. Unfortunately, the majority of the SNe observed by the MCSS and the CSP are discovered by searches carried out from the northern hemisphere. This entails a number of observational difficulties, in particular, it reduces the number of SNe for which the follow-up starts at very early epochs. The aim of the CHASE project is to remove this search bias by discovering young Southern SNe that will be extensively observed by the MCSS and the CSP. In the first nine-months of operation, CHASE has discovered two SNe: SN007oc (CBET 1114) and SN007pl (CBET 1130), thus demonstrating the feasibility of the survey.

  14. Chasing molecules: poisonous products, human health, and the promise of green chemistry

    National Research Council Canada - National Science Library

    Grossman, Elizabeth

    2009-01-01

    In Chasing Molecules, investigative journalist Elizabeth Grossman opens the door on a new world of chemistry-green chemistry - and the scientists who are unearthing the field's potential to transform...

  15. Avidin chase can reduce myelotoxicity associated with radioimmunotherapy of experimental liver micrometastases in mice

    International Nuclear Information System (INIS)

    Sato, Noriko; Saga, Tsuneo; Sakahara, Harumi; Nakamoto, Yuji; Zhao, Songji; Iida, Yasuhiko; Konishi, Junji; Kuroki, Masahide; Endo, Keigo

    2000-01-01

    Myelotoxicity is the main factor which decides the maximum tolerated dose (MTD) in radioimmunotherapy (RIT). Since bone marrow is mostly irradiated from blood radioactivity, enhancing the clearance of unbound circulating radiolabeled antibody is important to reduce myelotoxicity and to increase the MTD. We applied the avidin chase method, which was devised to obtain high tumor-to-background ratios in tumor-targeting, to RIT of experimental liver micrometastases and evaluated its influence on the side effects and therapeutic outcome. Seven days after intrasplenic injection of human colon cancer LS174T cells, nude mice were intravenously injected with biotinylated 131 I-labeled anti-CEA monoclonal antibody (MAb) (24-38 μg, 11.1 MBq). Mice of the chase group then received an intravenous injection of avidin twice (24 and 30 h, 72-115 μg each). Biodistribution, side effects (white blood cell counts and body weight change), and short- and long-term therapeutic effects were determined. Avidin chase markedly accelerated the clearance of radiolabeled MAb from the blood (P<0.0001) and normal tissues, resulting in milder leukocytopenia and body weight loss, both of which recovered earlier than in the non-chase group (P<0.01). The tumor uptake of radiolabeled MAb was also decreased by avidin chase, but the metastases-to-background ratios were increased. Avidin chase gave the therapeutic gain ratio of 1.89. Treated groups with and without avidin chase showed significant therapeutic effects compared to the non-treated group. There was no significant difference in the therapeutic effects between the two treated groups. Avidin chase effectively reduced the side effects of RIT and should increase the MTD. (author)

  16. Chelate chase of radiopharmaceuticals reversibly bound to monoclonal antibodies improves dosimetry

    International Nuclear Information System (INIS)

    Goodwin, D.A.; Smith, S.I.; Meares, C.F.; David, G.S.; McTigue, M.; Finston, R.A.

    1986-01-01

    One hundred micrograms of monoclonal antibody (MoAb) CHA 255 with a binding constant Kb of 4 x 10 9 was complexed with indium-111 labeled BLEDTA II, GLEDTA IV, benzyl EDTA, and an EDTA conjugate of Fab. The 24-hour tumor and organ distribution in BALB/c mice bearing KHJJ tumors was studied for each compound alone, the antibody complex, and 3 hours following a chelate chase of the antibody complex. Whole-body biological half-life was measured for 7 days with and without a chelate chase for each antibody complex. The 24-hour whole-body counts dropped 20-60% within 3 hours of administering the chelate chase. Blood concentration fell over 89% within 3 hours of administering the chase and there was a decrease in concentration in all organs, except the kidneys, of 10 to 85%. Theoretical equivalent human doses were calculated from the 24-hour organ concentrations, effective half-life, and MIRD 11 S values (absorbed dose per cumulated activity). Liver and spleen were the target organs, with the dose ranging from 0.50 to 3.91 rads per millicurie. The reduction in organ radiation dose varied up to 95% following the chelate chase. Rapid selective renal clearance of chelate labeled radiopharmaceuticals by competitive inhibition (chelate chase) of their reversible binding to monoclonal antibodies, greatly improves the radiation dosimetry of tumor imaging agents. 28 references, 5 figures, 5 tables

  17. Alexithymia predicts loss chasing for people at risk for problem gambling.

    Science.gov (United States)

    Bibby, Peter A; Ross, Katherine E

    2017-12-01

    Background and aims The aim of this research was to investigate the relationship between alexithymia and loss-chasing behavior in people at risk and not at risk for problem gambling. Methods An opportunity sample of 58 (50 males and 8 females) participants completed the Problem Gambling Severity Index and the Toronto Alexithymia Scale (TAS-20). They then completed the Cambridge Gambling Task from which a measure of loss-chasing behavior was derived. Results Alexithymia and problem gambling risk were significantly positively correlated. Subgroups of non-alexithymic and at or near caseness for alexithymia by low risk and at risk for problem gambling were identified. The results show a clear difference for loss-chasing behavior for the two alexithymia conditions, but there was no evidence that low and at-risk problem gamblers were more likely to loss chase. The emotion-processing components of the TAS-20 were shown to correlate with loss chasing. Discussion and conclusion These findings suggest that loss-chasing behavior may be particularly prevalent in a subgroup of problem gamblers those who are high in alexithymia.

  18. ECMO: Improving our Results by Chasing the Rabbits

    Directory of Open Access Journals (Sweden)

    Luiz Fernando Canêo

    2015-12-01

    Full Text Available ABSTRACT As Marcelo Giugale published in the Financial Times, Latin America, on the whole, has not excelled at innovation - doing the same things in a new and better way or at doing new things. It has been slow to acquire, adopt and adapt technologies by this time available in other places[1]. Although extracorporeal membrane oxygenation (ECMO is not a new technology, its use in Latin America is not widespread as needed. Furthermore, we still have a number centers doing ECMO, not reporting their cases, lacking a structured training program and not registered with the extracorporeal life support organization (ELSO. With this scenario, and accepting that ECMO is the first step in any circulatory support program, it is difficult to anticipate the incorporation of new and more complex devices as the technologically advanced world is currently doing. However, the good news is that with the support of experts from USA, Europe and Canada the results in Latin America ELSO'S centers are improving by following its guidelines for training, and using a standard educational process. There is no doubt that we can learn a great deal from the high velocity organizations - the rabbits - whom everyone chases but never catches, that manage to stay ahead because of their endurance, responsiveness, and their velocity in self-correction[2].

  19. Patterns of Light Chasing the Spectrum from Aristotle to LEDs

    CERN Document Server

    Beeson, Steven

    2008-01-01

    Light is all around us – even when we do not see it. Our eyes do not detect the higher energy and shorter-than-visible-wavelength ultraviolet radiation, yet we know it is there from the sunburn we receive in Arizona. We know that window glass can block ultraviolet rays so we do not get a burn while driving with the windows rolled up. Our eyes do not detect the low-energy, long-wavelength infrared (IR) radiation but we know it exists from discussions of war applications and televised images of guided weapons targets. We also know about radio waves from the little boxes that talk to us and x-rays from the dentist's office. Patterns of Light, Chasing the Spectrum from Aristotle to LEDs, written by Steve Beeson and Jim Mayer starts with the visible – the straight path of light. It continues with chapters detailing reflection (mirrors, storefront windows) and refraction (eyeglasses, binoculars). Color is then introduced with the query "Why is the sky blue?" After answering that and other similar questions ("Wh...

  20. Saving radiation dose and contrast media in intravenous digital subtraction angiography by use of bolus chasing

    International Nuclear Information System (INIS)

    Rueckforth, J.; Schuermann, K.; Vorwerk, D.; Guenther, R.W.

    1998-01-01

    Purpose: This study evaluates the dose area product, the amount of contrast media and the examination quality of the bolus chasing technique compared to the single-step technique in intravenous digital subtraction angiography. Material and Methods: 15 examinations each with bolus chasing and single-step technique were compared. The dose area product and the volume of contrast media were recorded. The examination quality was scored by two examiners. Results: With bolus chasing the volume of the administered contrast media could be decreased on average by 114 ml (43%). The difference between the dose area product of bolus chasing (722 dGy/cm 2 ) and single-step technique (1910 dGy/cm 2 ) was significant. No significant difference in examination quality was found. Conclusions: The intravenous bolus chasing technique is a practicable method. Compared to the single-step technique it allows a remarkable dose reduction and a low consumption of contrast media without restriction of examination quality. (orig.) [de

  1. GammeV and GammeV-CHASE

    International Nuclear Information System (INIS)

    Wester, W.

    2011-01-01

    Physics beyond the Standard Model might include Weakly Interacting Slim Particles (WISPs) that address questions such as what is the nature of dark matter or even shed insight into the underlying nature of dark energy. WISPs are a general class of particles that include axions, axion-like particles, hidden sector photons, milli-charged particles, chameleons, etc. The GammeV (Gamma to milli-eV) experiment originated in 2007 in order to test a positive anomalous axion-like particle interpretation of the PVLAS experiment which was not evident in subsequent data. The experiment was also motivated as it was realized that the milli-eV scale appears naturally in a see-saw between the electroweak and Planck scales, neutrino mass differences, the dark energy density, and the possible mass for certain dark matter candidates. GammeV was first to exclude both a scalar and pseudoscalar axion-like particle interpretation of the anomalous PVLAS result setting a limit of around 3.1 x 10 -7 GeV -1 on the coupling to photons for low mass axion-like particles. It has also been found that the parameter space of a variety of other WISP candidates is both largely unexplored and is accessible by modest experiments employing lasers and possibly accelerator magnets. GammeV data has also been used to set limits on possible hidden sector photons. Further work by the GammeV team has focused on a reconfiguration of the apparatus to be sensitive to possible chameleon particles. Chameleons are scalar (or pseudoscalar) particles that couple to the stress energy tensor in a potential such that their properties depend on their environment. In particular, a chameleon acquires an effective mass which increases with local matter density, ρ. For a certain class of such potentials, the chameleon field has properties that might explain dark energy. GammeV set the first limits on the coupling of chameleons to photons. A dedicated follow-up experiment, GammeV-CHASE, (CHameleon Afterglow SEarch), has also

  2. An Energy-Aware Hybrid ARQ Scheme with Multi-ACKs for Data Sensing Wireless Sensor Networks.

    Science.gov (United States)

    Zhang, Jinhuan; Long, Jun

    2017-06-12

    Wireless sensor networks (WSNs) are one of the important supporting technologies of edge computing. In WSNs, reliable communications are essential for most applications due to the unreliability of wireless links. In addition, network lifetime is also an important performance metric and needs to be considered in many WSN studies. In the paper, an energy-aware hybrid Automatic Repeat-reQuest protocol (ARQ) scheme is proposed to ensure energy efficiency under the guarantee of network transmission reliability. In the scheme, the source node sends data packets continuously with the correct window size and it does not need to wait for the acknowledgement (ACK) confirmation for each data packet. When the destination receives K data packets, it will return multiple copies of one ACK for confirmation to avoid ACK packet loss. The energy consumption of each node in flat circle network applying the proposed scheme is statistical analyzed and the cases under which it is more energy efficiency than the original scheme is discussed. Moreover, how to select parameters of the scheme is addressed to extend the network lifetime under the constraint of the network reliability. In addition, the energy efficiency of the proposed schemes is evaluated. Simulation results are presented to demonstrate that a node energy consumption reduction could be gained and the network lifetime is prolonged.

  3. PERFORMANCE ANALYSIS OF ARQ AND HYBRID ARQ OVER SINGLE-HOP, DUAL-HOP, AND MULTIBRANCH DUAL-HOP NETWORKS

    KAUST Repository

    Hadjtaieb, Amir

    2014-01-01

    During the last decade, relay networks have attracted a lot of interest due to their numerous benefits. The relaying technique allows extending the coverage zone of wireless networks and offers a higher reliability for communication systems

  4. Engaging Experiential Service Learning through a Co-Curricular Club: The Chase Charlie Races

    Science.gov (United States)

    Judge, Lawrence W.; Pierce, David; Petersen, Jeffrey; Bellar, David; Wanless, Elizabeth; Gilreath, Erin; Simon, Laura

    2011-01-01

    The efficacy of the "Chase Charlie Races" (an experiential learning activity) was demonstrated via program assessment. This was achieved via post-event evaluations of race participants and student club members, and with fitness assessments of 76 elementary students who participated in an eight-week training program. Paired sample t-tests revealed…

  5. Chase and NYANA: A Partnership To Remove Barriers to Job Performance 1993-94. Final Report.

    Science.gov (United States)

    Auerbach, Charles

    A workplace literacy program implemented cooperatively by the New York Association for New Americans, Inc. (NYANA) and Chase Manhattan Bank is reported. The federally-funded project provided individualized communication workplace behavior and skills training in English as a Second Language for 30 limited-English-proficient bank employees working…

  6. A Factor Increasing Venous Contamination on Bolus Chase Three-dimensional Magnetic Resonance Imaging: Charcot Neuroarthropathy.

    Science.gov (United States)

    Çildağ, Mehmet B; Ertuğrul, Mustafa B; Köseoğlu, Ömer Fk; Armstrong, David G

    2018-01-01

    The study aimed to evaluate the ratio of venous contamination in diabetic cases without foot lesion, with foot lesion and with Charcot neuroarthropathy (CN). Bolus-chase three-dimensional magnetic resonance (MR) of 396 extremities of patients with diabetes mellitus was analyzed, retrospectively. Extremities were divided into three groups as follows: diabetic patients without foot ulcer or Charcot arthropathy (Group A), patients with diabetic foot ulcers (Group B) and patients with CN accompanying diabetic foot ulcers (Group C). Furthermore, amount of venous contamination classified as no venous contamination, mild venous contamination, and severe venous contamination. The relationship between venous contamination and extremity groups was investigated. Severe venous contamination was seen in Group A, Group B, and Group C, 5.6%, 15.2%, and 34.1%, respectively. Statistically significant difference was seen between groups with regard to venous contamination. Venous contamination following bolus chase MR was higher in patients with CN.

  7. Fox Chase Cancer Center's Genitourinary Division: a national resource for research, innovation and patient care.

    Science.gov (United States)

    Uzzo, Robert G; Horwitz, Eric M; Plimack, Elizabeth R

    2016-04-01

    Founded in 1904, Fox Chase Cancer Center remains committed to its mission. It is one of 41 centers in the country designated as a Comprehensive Cancer Center by the National Cancer Institute, is a founding member of the National Comprehensive Cancer Network, holds the magnet designation for nursing excellence, is one of the first to establish a family cancer risk assessment program, and has achieved national distinction because of the scientific discoveries made there that have advanced clinical care. Two of its researchers have won Nobel prizes. The Genitourinary Division is nationally recognized and viewed as one of the top driving forces behind the growth of Fox Chase due to its commitment to initiating and participating in clinical trials, its prolific contributions to peer-reviewed publications and presentations at scientific meetings, its innovations in therapies and treatment strategies, and its commitment to bringing cutting-edge therapies to patients.

  8. A factor increasing venous contamination on bolus chase three-dimensional magnetic resonance imaging: Charcot neuroarthropathy

    Directory of Open Access Journals (Sweden)

    Mehmet B Cildag

    2018-01-01

    Full Text Available Background: The study aimed to evaluate the ratio of venous contamination in diabetic cases without foot lesion, with foot lesion and with Charcot neuroarthropathy (CN. Materials and Methods: Bolus-chase three-dimensional magnetic resonance (MR of 396 extremities of patients with diabetes mellitus was analyzed, retrospectively. Extremities were divided into three groups as follows: diabetic patients without foot ulcer or Charcot arthropathy (Group A, patients with diabetic foot ulcers (Group B and patients with CN accompanying diabetic foot ulcers (Group C. Furthermore, amount of venous contamination classified as no venous contamination, mild venous contamination, and severe venous contamination. The relationship between venous contamination and extremity groups was investigated. Results: Severe venous contamination was seen in Group A, Group B, and Group C, 5.6%, 15.2%, and 34.1%, respectively. Statistically significant difference was seen between groups with regard to venous contamination. Conclusion: Venous contamination following bolus chase MR was higher in patients with CN.

  9. Chasing losses in online poker and casino games: characteristics and game play of Internet gamblers at risk of disordered gambling.

    Science.gov (United States)

    Gainsbury, Sally M; Suhonen, Niko; Saastamoinen, Jani

    2014-07-30

    Disordered Internet gambling is a psychological disorder that represents an important public health issue due to the increase in highly available and conveniently accessible Internet gambling sites. Chasing losses is one of the few observable markers of at-risk and problem gambling that may be used to detect early signs of disordered Internet gambling. This study examined loss chasing behaviour in a sample of Internet casino and poker players and the socio-demographic variables, irrational beliefs, and gambling behaviours associated with chasing losses. An online survey was completed by 10,838 Internet gamblers (58% male) from 96 countries. The results showed that Internet casino players had a greater tendency to report chasing losses than poker players and gamblers who reported chasing losses were more likely to hold irrational beliefs about gambling and spend more time and money gambling than those who reported that they were unaffected by previous losses. Gamblers who played for excitement and to win money were more likely to report chasing losses. This study is one of the largest ever studies of Internet gamblers and the results are highly significant as they provide insight into the characteristics and behaviours of gamblers using this mode of access. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  10. Behaviorism Makes Its Debut: A Review of Lattal and Chase's Behavior Theory and Philosophy

    OpenAIRE

    Zuriff, G.E

    2005-01-01

    Behavior Theory and Philosophy, masterfully edited by Lattal and Chase, is a collection of 21 papers by major behaviorists, presented and discussed at a conference on the intersection of philosophy and behavior analysis held at West Virginia University in 2000. The chapters in Part I are devoted to philosophy of science (causality, constructs, theory, explanation, reductionism) and the relations among behavior analysis and several contemporary philosophical movements (humanism, empiricism, pr...

  11. Cheetahs, Acinonyx jubatus, balance turn capacity with pace when chasing prey

    Science.gov (United States)

    Wilson, John W.; Mills, Michael G. L.; Wilson, Rory P.; Peters, Gerrit; Mills, Margaret E. J.; Speakman, John R.; Durant, Sarah M.; Bennett, Nigel C.; Marks, Nikki J.; Scantlebury, Michael

    2013-01-01

    Predator–prey interactions are fundamental in the evolution and structure of ecological communities. Our understanding, however, of the strategies used in pursuit and evasion remains limited. Here, we report on the hunting dynamics of the world's fastest land animal, the cheetah, Acinonyx jubatus. Using miniaturized data loggers, we recorded fine-scale movement, speed and acceleration of free-ranging cheetahs to measure how hunting dynamics relate to chasing different sized prey. Cheetahs attained hunting speeds of up to 18.94 m s−1 and accelerated up to 7.5 m s−2 with greatest angular velocities achieved during the terminal phase of the hunt. The interplay between forward and lateral acceleration during chases showed that the total forces involved in speed changes and turning were approximately constant over time but varied with prey type. Thus, rather than a simple maximum speed chase, cheetahs first accelerate to decrease the distance to their prey, before reducing speed 5–8 s from the end of the hunt, so as to facilitate rapid turns to match prey escape tactics, varying the precise strategy according to prey species. Predator and prey thus pit a fine balance of speed against manoeuvring capability in a race for survival. PMID:24004493

  12. Cheetahs, Acinonyx jubatus, balance turn capacity with pace when chasing prey.

    Science.gov (United States)

    Wilson, John W; Mills, Michael G L; Wilson, Rory P; Peters, Gerrit; Mills, Margaret E J; Speakman, John R; Durant, Sarah M; Bennett, Nigel C; Marks, Nikki J; Scantlebury, Michael

    2013-10-23

    Predator-prey interactions are fundamental in the evolution and structure of ecological communities. Our understanding, however, of the strategies used in pursuit and evasion remains limited. Here, we report on the hunting dynamics of the world's fastest land animal, the cheetah, Acinonyx jubatus. Using miniaturized data loggers, we recorded fine-scale movement, speed and acceleration of free-ranging cheetahs to measure how hunting dynamics relate to chasing different sized prey. Cheetahs attained hunting speeds of up to 18.94 m s(-1) and accelerated up to 7.5 m s(-2) with greatest angular velocities achieved during the terminal phase of the hunt. The interplay between forward and lateral acceleration during chases showed that the total forces involved in speed changes and turning were approximately constant over time but varied with prey type. Thus, rather than a simple maximum speed chase, cheetahs first accelerate to decrease the distance to their prey, before reducing speed 5-8 s from the end of the hunt, so as to facilitate rapid turns to match prey escape tactics, varying the precise strategy according to prey species. Predator and prey thus pit a fine balance of speed against manoeuvring capability in a race for survival.

  13. Chasing the limits of the one electron approximation

    Energy Technology Data Exchange (ETDEWEB)

    Kędziera, Dariusz [Department of Chemistry, Nicolaus Copernicus University, Gagarina 7, 87-100 Toruń (Poland); Mentel, Łukasz M. [Section of Theoretical Chemistry, VU University, Amsterdam (Netherlands)

    2014-10-06

    Rapid progress in the development of computational methods for quantum chemistry is not properly balanced by the development of basis sets. Even in the case of few-electron systems it is hard to find basis set which are able to reproduce the ECG benchmarks with the mhartree accuracy. In this paper we show early work on improvements of the basis sets for small atomic and molecular systems. As a starting point the ground state of lithium atom and the lowest states of lithium dimer will be investigated. The exploratory optimization of the exponents of primitive gaussians will be based on even tempered scheme combined with CISD method.

  14. Terrestrial carbon storage dynamics: Chasing a moving target

    Science.gov (United States)

    Luo, Y.; Shi, Z.; Jiang, L.; Xia, J.; Wang, Y.; Kc, M.; Liang, J.; Lu, X.; Niu, S.; Ahlström, A.; Hararuk, O.; Hastings, A.; Hoffman, F. M.; Medlyn, B. E.; Rasmussen, M.; Smith, M. J.; Todd-Brown, K. E.; Wang, Y.

    2015-12-01

    Terrestrial ecosystems have been estimated to absorb roughly 30% of anthropogenic CO2 emissions. Past studies have identified myriad drivers of terrestrial carbon storage changes, such as fire, climate change, and land use changes. Those drivers influence the carbon storage change via diverse mechanisms, which have not been unified into a general theory so as to identify what control the direction and rate of terrestrial carbon storage dynamics. Here we propose a theoretical framework to quantitatively determine the response of terrestrial carbon storage to different exogenous drivers. With a combination of conceptual reasoning, mathematical analysis, and numeric experiments, we demonstrated that the maximal capacity of an ecosystem to store carbon is time-dependent and equals carbon input (i.e., net primary production, NPP) multiplying by residence time. The capacity is a moving target toward which carbon storage approaches (i.e., the direction of carbon storage change) but usually does not attain. The difference between the capacity and the carbon storage at a given time t is the unrealized carbon storage potential. The rate of the storage change is proportional to the magnitude of the unrealized potential. We also demonstrated that a parameter space of NPP, residence time, and carbon storage potential can well characterize carbon storage dynamics quantified at six sites ranging from tropical forests to tundra and simulated by two versions (carbon-only and coupled carbon-nitrogen) of the Australian Community Atmosphere-Biosphere Land Ecosystem (CABLE) Model under three climate change scenarios (CO2 rising only, climate warming only, and RCP8.5). Overall this study reveals the unified mechanism unerlying terrestrial carbon storage dynamics to guide transient traceability analysis of global land models and synthesis of empirical studies.

  15. Pilots' Attention Distributions Between Chasing a Moving Target and a Stationary Target.

    Science.gov (United States)

    Li, Wen-Chin; Yu, Chung-San; Braithwaite, Graham; Greaves, Matthew

    2016-12-01

    Attention plays a central role in cognitive processing; ineffective attention may induce accidents in flight operations. The objective of the current research was to examine military pilots' attention distributions between chasing a moving target and a stationary target. In the current research, 37 mission-ready F-16 pilots participated. Subjects' eye movements were collected by a portable head-mounted eye-tracker during tactical training in a flight simulator. The scenarios of chasing a moving target (air-to-air) and a stationary target (air-to-surface) consist of three operational phases: searching, aiming, and lock-on to the targets. The findings demonstrated significant differences in pilots' percentage of fixation during the searching phase between air-to-air (M = 37.57, SD = 5.72) and air-to-surface (M = 33.54, SD = 4.68). Fixation duration can indicate pilots' sustained attention to the trajectory of a dynamic target during air combat maneuvers. Aiming at the stationary target resulted in larger pupil size (M = 27,105, SD = 6565), reflecting higher cognitive loading than aiming at the dynamic target (M = 23,864, SD = 8762). Pilots' visual behavior is not only closely related to attention distribution, but also significantly associated with task characteristics. Military pilots demonstrated various visual scan patterns for searching and aiming at different types of targets based on the research settings of a flight simulator. The findings will facilitate system designers' understanding of military pilots' cognitive processes during tactical operations. They will assist human-centered interface design to improve pilots' situational awareness. The application of an eye-tracking device integrated with a flight simulator is a feasible and cost-effective intervention to improve the efficiency and safety of tactical training.Li W-C, Yu C-S, Braithwaite G, Greaves M. Pilots' attention distributions between chasing a moving target and a stationary target. Aerosp Med

  16. The neutron therapy facility at the University of Pennsylvania-Fox Chase Cancer Center

    International Nuclear Information System (INIS)

    Bloch, P.; Chu, J.; Larsen, R.

    1983-01-01

    The fusion of deuterium and tritium nuclei results in the formation of a helium-4 nucleus and a 14 MEV neutron. This reaction readily takes place when deuterium and tritium ions are accelerated to potentials between 150-200 kV. These energy ions can be obtained in a moderate size accelerator. A DT neutron facility has been installed in the radiation therapy department of the University of Pennsylvania Hospital-Fox Chase Cancer Center. The system is being commissioned in a hospital setting to test the efficacy of fast neutron radiotherapy

  17. The application of DSA bolus chase technology in diagnosing the vascular disorders of lower extremities due to diabetes mellitus

    International Nuclear Information System (INIS)

    Ren Chongyang; Di Zhenhai; Mao Xuequn; Zou Rong; Zhang Jian; Wang Meirong; Li Quan

    2010-01-01

    Objective: To retrospectively evaluate the digital subtraction angiography (DSA) bolus chase technology in diagnosing the vascular disorders of lower extremities due to diabetes mellitus. Methods: From January 2004 to March 2010, DSA was performed in forty-five diabetes patients with suspicious vascular diseases of lower extremities. Among them, 24 cases (31 lower limbs)were examined with DSA bolus chase technology and the remaining 21 cases (21 lower limbs)were examined with traditional segmentational technique. The contrast dosage used in angiography, the total exposure time, the examination time and the imaging value for making diagnosis were analyzed and compared between two techniques. Results: For DSA bolus chase technology group, the contrast dosage used in angiography, the total exposure time and the examination time were 25.26 ml, 13.23 s and 37.26 min, respectively,with an average exposure of 101.65 pictures. For traditional segmentational technique group, the contrast dosage used in angiography, the total exposure time and the examination time were 130.00 ml, 52.38 s and 50.48 min, respectively, with an average exposure of 118.33 pictures. The percentage of high quality images in bolus chase technology group and in traditional segmentational technique group were 90.3% and 90.5%, respectively. All the images could meet the requirements for making a reliable diagnosis. Conclusion: Digital subtraction angiography by using bolus-chase technology can well demonstrate the vascular pathology of lower extremities caused by diabetes mellitus, obtain sufficient imaging information necessary for making a reliable diagnosis. DSA bolus chase technology is superior to traditional segmentational technique in shortening procedure time, reducing contrast medium dosage and decreasing radiation dose. (authors)

  18. Collective chasing behavior between cooperators and defectors in the spatial prisoner's dilemma.

    Directory of Open Access Journals (Sweden)

    Genki Ichinose

    Full Text Available Cooperation is one of the essential factors for all biological organisms in major evolutionary transitions. Recent studies have investigated the effect of migration for the evolution of cooperation. However, little is known about whether and how an individuals' cooperativeness coevolves with mobility. One possibility is that mobility enhances cooperation by enabling cooperators to escape from defectors and form clusters; the other possibility is that mobility inhibits cooperation by helping the defectors to catch and exploit the groups of cooperators. In this study we investigate the coevolutionary dynamics by using the prisoner's dilemma game model on a lattice structure. The computer simulations demonstrate that natural selection maintains cooperation in the form of evolutionary chasing between the cooperators and defectors. First, cooperative groups grow and collectively move in the same direction. Then, mutant defectors emerge and invade the cooperative groups, after which the defectors exploit the cooperators. Then other cooperative groups emerge due to mutation and the cycle is repeated. Here, it is worth noting that, as a result of natural selection, the mobility evolves towards directional migration, but not to random or completely fixed migration. Furthermore, with directional migration, the rate of global population extinction is lower when compared with other cases without the evolution of mobility (i.e., when mobility is preset to random or fixed. These findings illustrate the coevolutionary dynamics of cooperation and mobility through the directional chasing between cooperators and defectors.

  19. CHASE '10

    DEFF Research Database (Denmark)

    Software is created by people---software engineers---working in varied environments, under various conditions. Thus understanding cooperative and human aspect of software development is crucial to comprehend how methods and tools are used, and thereby improving the creation and maintenance of sof...

  20. Chasing volatility

    DEFF Research Database (Denmark)

    Caporin, Massimiliano; Rossi, Eduardo; Santucci de Magistris, Paolo

    The realized volatility of financial returns is characterized by persistence and occurrence of unpreditable large increments. To capture those features, we introduce the Multiplicative Error Model with jumps (MEM-J). When a jump component is included in the multiplicative specification, the condi......The realized volatility of financial returns is characterized by persistence and occurrence of unpreditable large increments. To capture those features, we introduce the Multiplicative Error Model with jumps (MEM-J). When a jump component is included in the multiplicative specification...... estimate alternative specifications of the model using a set of daily bipower measures for 7 stock indexes and 16 individual NYSE stocks. The estimates of the jump component confirm that the probability of jumps dramatically increases during the financial crisis. Compared to other realized volatility...... models, the introduction of the jump component provides a sensible improvement in the fit, as well as for in-sample and out-of-sample volatility tail forecasts....

  1. 76 FR 31955 - Jonathan and Jayne Chase; Notice of Application Accepted for Filing With the Commission, Intent...

    Science.gov (United States)

    2011-06-02

    .... c. Date filed: July 23, 2010. d. Applicant: Jonathan and Jayne Chase. e. Name of Project: Troy Hydropower Project. f. Location: On the Missisquoi River, in the Town of Troy, Orleans County, Vermont. The... filing and is now ready for environmental analysis. l. Project Description: The Troy Project would...

  2. Biosynthesis of intestinal microvillar proteins. Pulse-chase labelling studies on maltase-glucoamylase, aminopeptidase A and dipeptidyl peptidase IV

    DEFF Research Database (Denmark)

    Danielsen, E M; Sjöström, H; Norén, Ove

    1983-01-01

    The biogenesis of three intestinal microvillar enzymes, maltase-glucoamylase (EC 3.2.1.20), aminopeptidase A (aspartate aminopeptidase, EC 3.4.11.7) and dipeptidyl peptidase IV (EC 3.4.14.5), was studied by pulse-chase labelling of pig small-intestinal explants kept in organ culture. The earliest...

  3. Turnover rates in microorganisms by laser ablation electrospray ionization mass spectrometry and pulse-chase analysis

    Energy Technology Data Exchange (ETDEWEB)

    Stopka, Sylwia A.; Mansour, Tarek R.; Shrestha, Bindesh [Department of Chemistry, W.M. Keck Institute for Proteomics Technology and Applications, The George Washington University, Washington, DC 20052 (United States); Maréchal, Éric; Falconet, Denis [Laboratoire de Physiologie Cellulaire et Végétale, UMR 5168, CEA-CNRS-INRA-Univ. Grenoble Alpes, Grenoble (France); Vertes, Akos, E-mail: vertes@gwu.edu [Department of Chemistry, W.M. Keck Institute for Proteomics Technology and Applications, The George Washington University, Washington, DC 20052 (United States)

    2016-01-01

    Biochemical processes rely on elaborate networks containing thousands of compounds participating in thousands of reaction. Rapid turnover of diverse metabolites and lipids in an organism is an essential part of homeostasis. It affects energy production and storage, two important processes utilized in bioengineering. Conventional approaches to simultaneously quantify a large number of turnover rates in biological systems are currently not feasible. Here we show that pulse-chase analysis followed by laser ablation electrospray ionization mass spectrometry (LAESI-MS) enable the simultaneous and rapid determination of metabolic turnover rates. The incorporation of ion mobility separation (IMS) allowed an additional dimension of analysis, i.e., the detection and identification of isotopologs based on their collision cross sections. We demonstrated these capabilities by determining metabolite, lipid, and peptide turnover in the photosynthetic green algae, Chlamydomonas reinhardtii, in the presence of {sup 15}N-labeled ammonium chloride as the main nitrogen source. Following the reversal of isotope patterns in the chase phase by LAESI-IMS-MS revealed the turnover rates and half-lives for biochemical species with a wide range of natural concentrations, e.g., chlorophyll metabolites, lipids, and peptides. For example, the half-lives of lyso-DGTS(16:0) and DGTS(18:3/16:0), t{sub 1/2} = 43.6 ± 4.5 h and 47.6 ± 2.2 h, respectively, provided insight into lipid synthesis and degradation in this organism. Within the same experiment, half-lives for chlorophyll a, t{sub 1/2} = 24.1 ± 2.2 h, and a 2.8 kDa peptide, t{sub 1/2} = 10.4 ± 3.6 h, were also determined. - Highlights: • High-throughput pulse-chase analysis using direct sampling of biological cells. • Ion mobility separation for the elucidation of isotopologs. • Identification of isotopologs in difference heat plots of DT vs. m/z. • Simultaneous determination of turnover rates for lipids and

  4. Relaciones citotaxonómicas entre Paspalum almum Chase y P. hexastachyum Parodi (Gramineae

    Directory of Open Access Journals (Sweden)

    Camilo L Quarín

    1974-01-01

    Full Text Available El autor describe el grupo Alrna del género Paspalum, sobre la base de un manuscrito de Parodi y Nicora (1966. Lleva a cabo un estudio morfológico y citológico de las dos especies que constituyen este grupo: P.almum Chase y Parodi P.hexastachyurn.  P.alrnum presenta veinticuatro cromosomas somáticos y en Metafase I, se comporta como una especie autotetraploide formada a 6 IV's. Aquí se informa, por primera vez, un recuento cromosómico de P.hexastachyum (2n = 12. Este es el número más bajo, conocido para el género Paspalum, lo que confirma la presencia del número básico x = 6, a diferencia del más frecuente en el género, que es x = 10.

  5. Behaviorism Makes Its Debut: A Review of Lattal and Chase's Behavior Theory and Philosophy

    Science.gov (United States)

    Zuriff, G.E

    2005-01-01

    Behavior Theory and Philosophy, masterfully edited by Lattal and Chase, is a collection of 21 papers by major behaviorists, presented and discussed at a conference on the intersection of philosophy and behavior analysis held at West Virginia University in 2000. The chapters in Part I are devoted to philosophy of science (causality, constructs, theory, explanation, reductionism) and the relations among behavior analysis and several contemporary philosophical movements (humanism, empiricism, pragmatism, selectionism, analytic philosophy). Part II examines behavior-analytic interpretations of mentalistic concepts (intention, imagination, ethics, cognition). Part III presents extensions and applications of basic research in behavior analysis (verbal behavior, creativity, development, education, disability, and corporate culture). The publication of this book signals that behaviorism has developed mature philosophical foundations.

  6. Chasing The 'Like': Adolescent Use Of Social Networking Sites In Australia.

    Science.gov (United States)

    la Sala, Louise; Skues, Jason; Wise, Lisa; Theiler, Stephen

    2015-01-01

    The current study investigated how adolescents behave on Social Networking Sites (SNSs) and how they interpret the feedback they receive online from others. Thirty-four Australian adolescents (26 girls, 8 boys) aged 13 to 17 years participated in the study. Five semi-structured focus groups (3 mixed groups, 2 all-girl groups) were conducted to explore how adolescents perceive their own and others' SNS behaviours, the motivation underlying these behaviours, and the expected outcomes related to particular behaviours. Teenagers reported that they spend a good deal of time planning their SNS posts, felt that the information they posted was a true reflection of them as a person, and thus interpreted feedback ("likes") as measuring their self-worth. In contrast, some teenagers were perceived as "chasing the like" for status and popularity while not caring about how accurately their posts represented them as a person. A potential gender bias in these findings is discussed.

  7. A Vicious Cycle: A Cross-Sectional Study of Canine Tail-Chasing and Human Responses to It, Using a Free Video-Sharing Website

    Science.gov (United States)

    Burn, Charlotte C.

    2011-01-01

    Tail-chasing is widely celebrated as normal canine behaviour in cultural references. However, all previous scientific studies of tail-chasing or ‘spinning’ have comprised small clinical populations of dogs with neurological, compulsive or other pathological conditions; most were ultimately euthanased. Thus, there is great disparity between scientific and public information on tail-chasing. I gathered data on the first large (n = 400), non-clinical tail-chasing population, made possible through a vast, free, online video repository, YouTube™. The demographics of this online population are described and discussed. Approximately one third of tail-chasing dogs showed clinical signs, including habitual (daily or ‘all the time’) or perseverative (difficult to distract) performance of the behaviour. These signs were observed across diverse breeds. Clinical signs appeared virtually unrecognised by the video owners and commenting viewers; laughter was recorded in 55% of videos, encouragement in 43%, and the commonest viewer descriptors were that the behaviour was ‘funny’ (46%) or ‘cute’ (42%). Habitual tail-chasers had 6.5+/−2.3 times the odds of being described as ‘Stupid’ than other dogs, and perseverative dogs were 6.8+/−2.1 times more frequently described as ‘Funny’ than distractible ones were. Compared with breed- and age-matched control videos, tail-chasing videos were significantly more often indoors and with a computer/television screen switched on. These findings highlight that tail-chasing is sometimes pathological, but can remain untreated, or even be encouraged, because of an assumption that it is ‘normal’ dog behaviour. The enormous viewing figures that YouTube™ attracts (mean+/−s.e. = 863+/−197 viewings per tail-chasing video) suggest that this perception will be further reinforced, without effective intervention. PMID:22096487

  8. A vicious cycle: a cross-sectional study of canine tail-chasing and human responses to it, using a free video-sharing website.

    Directory of Open Access Journals (Sweden)

    Charlotte C Burn

    Full Text Available Tail-chasing is widely celebrated as normal canine behaviour in cultural references. However, all previous scientific studies of tail-chasing or 'spinning' have comprised small clinical populations of dogs with neurological, compulsive or other pathological conditions; most were ultimately euthanased. Thus, there is great disparity between scientific and public information on tail-chasing. I gathered data on the first large (n = 400, non-clinical tail-chasing population, made possible through a vast, free, online video repository, YouTube™. The demographics of this online population are described and discussed. Approximately one third of tail-chasing dogs showed clinical signs, including habitual (daily or 'all the time' or perseverative (difficult to distract performance of the behaviour. These signs were observed across diverse breeds. Clinical signs appeared virtually unrecognised by the video owners and commenting viewers; laughter was recorded in 55% of videos, encouragement in 43%, and the commonest viewer descriptors were that the behaviour was 'funny' (46% or 'cute' (42%. Habitual tail-chasers had 6.5+/-2.3 times the odds of being described as 'Stupid' than other dogs, and perseverative dogs were 6.8+/-2.1 times more frequently described as 'Funny' than distractible ones were. Compared with breed- and age-matched control videos, tail-chasing videos were significantly more often indoors and with a computer/television screen switched on. These findings highlight that tail-chasing is sometimes pathological, but can remain untreated, or even be encouraged, because of an assumption that it is 'normal' dog behaviour. The enormous viewing figures that YouTube™ attracts (mean+/-s.e. = 863+/-197 viewings per tail-chasing video suggest that this perception will be further reinforced, without effective intervention.

  9. 'Chasing the Dragon' - imaging of heroin inhalation leukoencephalopathy

    Energy Technology Data Exchange (ETDEWEB)

    Hagel, J. [Vancouver General Hospital, Dept. of Radiology, Vancouver, British Columbia (Canada)]. E-mail: jeff_hagel@hotmail.com; Andrews, G. [UBC Hospital, Dept. of Radiology, Vancouver, British Columbia (Canada); Vertinsky, T. [Vancouver General Hospital, Dept. of Radiology, Vancouver, British Columbia (Canada); Heran, M.K.S. [Vancouver General Hospital, Div. of Neuroradiology, Vancouver, British Columbia (Canada); Keogh, C. [BC Cancer Agency, Dept. of Radiology, Vancouver, British Columbia (Canada)

    2005-10-15

    'Chasing the dragon' refers to the inhalation of heroin pyrolysate vapors produced when the freebase form of heroin is heated. Inhalation of these vapors can result in a rare toxic spongiform leukoencephalopathy. The patients may progress through 3 defined clinical stages, with one-quarter reaching the terminal stage, which invariably leads to death. Imaging and, in particular, magnetic resonance imaging (MRI) demonstrates white matter findings that are felt to be specific for this entity and essential in its early diagnosis. We present the typical imaging findings in a pictorial essay format, using images taken from 9 patients who presented within an 18-month period at UBC-affiliated hospitals. These findings include low computed tomography (CT) attenuation and high T2 MRI signal most commonly in the posterior cerebral and cerebellar white matter, cerebellar peduncles, splenium of the corpus callosum, and posterior limb of the internal capsules. In addition, there is often selective, symmetric involvement of the corticospinal tract, the medial lemniscus, and the tractus solitarius. We also present the variable diffusion-weighted imaging arid apparent diffusion coefficient findings from 4 of our patients, which to our knowledge, have not been described in the literature. (author)

  10. "Sniffer"—a novel tool for chasing vehicles and measuring traffic pollutants

    Science.gov (United States)

    Pirjola, L.; Parviainen, H.; Hussein, T.; Valli, A.; Hämeri, K.; Aaalto, P.; Virtanen, A.; Keskinen, J.; Pakkanen, T. A.; Mäkelä, T.; Hillamo, R. E.

    To measure traffic pollutants with high temporal and spatial resolution under real conditions a mobile laboratory was designed and built in Helsinki Polytechnic in close co-operation with the University of Helsinki. The equipment of the van provides gas phase measurements of CO and NO x, number size distribution measurements of fine and ultrafine particles by an electrical low pressure impactor, an ultrafine condensation particle counter and a scanning mobility particle sizer. Two inlet systems, one above the windshield and the other above the bumper, enable chasing of different type of vehicles. Also, meteorological and geographical parameters are recorded. This paper introduces the construction and technical details of the van, and presents data from the measurements performed during an LIPIKA campaign on the highway in Helsinki. Approximately 90% of the total particle number concentration was due to particles smaller than 50 nm on the highway in Helsinki. The peak concentrations exceeded often 200,000 particles cm -3 and reached sometimes a value of 10 6 cm -3. Typical size distribution of fine particles possessed bimodal structure with the modal mean diameters of 15-20 nm and ˜150 nm. Atmospheric dispersion of traffic pollutions were measured by moving away from the highway along the wind direction. At a distance of 120-140 m from the source the concentrations were diluted to one-tenth from the values at 9 m from the source.

  11. Coevolutionary arms race versus host defense chase in a tropical herbivore-plant system.

    Science.gov (United States)

    Endara, María-José; Coley, Phyllis D; Ghabash, Gabrielle; Nicholls, James A; Dexter, Kyle G; Donoso, David A; Stone, Graham N; Pennington, R Toby; Kursar, Thomas A

    2017-09-05

    Coevolutionary models suggest that herbivores drive diversification and community composition in plants. For herbivores, many questions remain regarding how plant defenses shape host choice and community structure. We addressed these questions using the tree genus Inga and its lepidopteran herbivores in the Amazon. We constructed phylogenies for both plants and insects and quantified host associations and plant defenses. We found that similarity in herbivore assemblages between Inga species was correlated with similarity in defenses. There was no correlation with phylogeny, a result consistent with our observations that the expression of defenses in Inga is independent of phylogeny. Furthermore, host defensive traits explained 40% of herbivore community similarity. Analyses at finer taxonomic scales showed that different lepidopteran clades select hosts based on different defenses, suggesting taxon-specific histories of herbivore-host plant interactions. Finally, we compared the phylogeny and defenses of Inga to phylogenies for the major lepidopteran clades. We found that closely related herbivores fed on Inga with similar defenses rather than on closely related plants. Together, these results suggest that plant defenses might be more evolutionarily labile than the herbivore traits related to host association. Hence, there is an apparent asymmetry in the evolutionary interactions between Inga and its herbivores. Although plants may evolve under selection by herbivores, we hypothesize that herbivores may not show coevolutionary adaptations, but instead "chase" hosts based on the herbivore's own traits at the time that they encounter a new host, a pattern more consistent with resource tracking than with the arms race model of coevolution.

  12. Intravenous avidin chase improved localization of radiolabeled streptavidin in intraperitoneal xenograft pretargeted with biotinylated antibody

    International Nuclear Information System (INIS)

    Zhang Meili; Sakahara, Harumi; Yao Zhengsheng; Saga, Tsuneo; Nakamoto, Yuhi; Sato, Noriko; Nakada, Hiroshi; Yamashina, Ikuo; Konishi, Junji

    1997-01-01

    In the present study, we examined the effect of avidin administered intravenously (i.v.) on the biodistribution of radiolabeled streptavidin in mice bearing intraperitoneal (IP) xenografts pretargeted with biotinylated antibody. Tumors were established in nude mice by IP inoculation of LS180 human colon cancer cells. Monoclonal antibody MLS128, which recognizes Tn antigen on mucin, was biotinylated and injected IP into the IP tumor-bearing mice. Radioiodinated streptavidin was administered IP or i.v. 48 h after pretargeting of biotinylated antibody. Avidin was administered i.v. 30 min prior to streptavidin injection. The localization of radioiodinated streptavidin in the tumor pretargeted with biotinylated antibody was significantly higher than that without pretargeting and that of radioiodinated MLS128 by the one-step method. Avidin administration significantly accelerated the clearance of radioiodinated streptavidin in blood and other normal tissues and increased the tumor-to-blood radioactivity ratio regardless of administration route of streptavidin. The i.v. avidin chase improved tumor localization of radiolabeled streptavidin in the IP xenografts pretargeted with biotinylated antibody

  13. Manufacture and test of prototype water pipe chase barrier in ITER Magnet Feeder system

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Kun, E-mail: lukun@ipp.ac.cn [Institute of Plasma Physics, Shushan Hu Road 350, Hefei, Anhui (China); Wen, Xinjie; Liu, Chen; Song, Yuntao [Institute of Plasma Physics, Shushan Hu Road 350, Hefei, Anhui (China); Niu, Erwu [ITER China, 15B Fuxing Road, Beijing 100862 (China); Gung, Chenyu; Su, Man [ITER Organization, Route de Vinon-sur-Verdon – CS 90046, 13067 St Paul-lez-Durance Cedex (France)

    2016-11-01

    The Magnet Feeder system in the International Thermonuclear Experimental Reactor (ITER) deploys electrical currents and supercritical helium to the superconducting magnets and the magnet diagnostic signals to the operators. In the current design, the feeders located in the upper L3 level of the Tokamak gallery penetrate the Tokamak coolant water system vault, the biological shield and the cryostat. As a secondary confinement to contain the activated coolant water in the vault in the case of water pipe burst accident, a water barrier is welded between the penetration in the water pipe chase outer wall and the mid-plane of the vacuum jacket of the Feeder Coil Terminal Box (CTB). A thin-wall stainless steel diaphragm with an omega shape profile is welded around the CTB as the water barrier to endure 2 bar hydraulic pressure. In addition, the barrier is designed as a flexible compensator to withstand a maximum of 15 mm of axial displacement of the CTB in case of helium leak accident without failure. This paper presents the detail configuration, the manufacturing and assembly processes of the water barrier. Test results of the prototype water barrier under simulated accident conditions are also reported. Successful qualification of the design and manufacturing process of the water barrier lays a good foundation for the series production of this subsystem.

  14. Quantitative Measurement of GPCR Endocytosis via Pulse-Chase Covalent Labeling.

    Directory of Open Access Journals (Sweden)

    Hidetoshi Kumagai

    Full Text Available G protein-coupled receptors (GPCRs play a critical role in many physiological systems and represent one of the largest families of signal-transducing receptors. The number of GPCRs at the cell surface regulates cellular responsiveness to their cognate ligands, and the number of GPCRs, in turn, is dynamically controlled by receptor endocytosis. Recent studies have demonstrated that GPCR endocytosis, in addition to affecting receptor desensitization and resensitization, contributes to acute G protein-mediated signaling. Thus, endocytic GPCR behavior has a significant impact on various aspects of physiology. In this study, we developed a novel GPCR internalization assay to facilitate characterization of endocytic GPCR behavior. We genetically engineered chimeric GPCRs by fusing HaloTag (a catalytically inactive derivative of a bacterial hydrolase to the N-terminal end of the receptor (HT-GPCR. HaloTag has the ability to form a stable covalent bond with synthetic HaloTag ligands that contain fluorophores or a high-affinity handle (such as biotin and the HaloTag reactive linker. We selectively labeled HT-GPCRs at the cell surface with a HaloTag PEG ligand, and this pulse-chase covalent labeling allowed us to directly monitor the relative number of internalized GPCRs after agonist stimulation. Because the endocytic activities of GPCR ligands are not necessarily correlated with their agonistic activities, applying this novel methodology to orphan GPCRs, or even to already characterized GPCRs, will increase the likelihood of identifying currently unknown ligands that have been missed by conventional pharmacological assays.

  15. Visual processing in rapid-chase systems: Image processing, attention, and awareness

    Directory of Open Access Journals (Sweden)

    Thomas eSchmidt

    2011-07-01

    Full Text Available Visual stimuli can be classified so rapidly that their analysis may be based on a single sweep of feedforward processing through the visuomotor system. Behavioral criteria for feedforward processing can be evaluated in response priming tasks where speeded pointing or keypress responses are performed towards target stimuli which are preceded by prime stimuli. We apply this method to several classes of complex stimuli. 1 When participants classify natural images into animals or non-animals, the time course of their pointing responses indicates that prime and target signals remain strictly sequential throughout all processing stages, meeting stringent behavioral criteria for feedforward processing (rapid-chase criteria. 2 Such priming effects are boosted by selective visual attention for positions, shapes, and colors, in a way consistent with bottom-up enhancement of visuomotor processing, even when primes cannot be consciously identified. 3 Speeded processing of phobic images is observed in participants specifically fearful of spiders or snakes, suggesting enhancement of feedforward processing by long-term perceptual learning. 4 When the perceived brightness of primes in complex displays is altered by means of illumination or transparency illusions, priming effects in speeded keypress responses can systematically contradict subjective brightness judgments, such that one prime appears brighter than the other but activates motor responses as if it was darker. We propose that response priming captures the output of the first feedforward pass of visual signals through the visuomotor system, and that this output lacks some characteristic features of more elaborate, recurrent processing. This way, visuomotor measures may become dissociated from several aspects of conscious vision. We argue that "fast" visuomotor measures predominantly driven by feedforward processing should supplement "slow" psychophysical measures predominantly based on visual

  16. SR-71B - in Flight with F-18 Chase Aircraft - View from Air Force Tanker

    Science.gov (United States)

    1996-01-01

    NASA 831, an SR-71B operated by the Dryden Flight Research Center, Edwards, California, cruises over the Mojave Desert with an F/A-18 Hornet flying safety chase. They were photographed on a 1996 mission from an Air Force refueling tanker The F/A-18 Hornet is used primarily as a safety chase and support aircraft at Dryden. As support aircraft, the F-18s are used for safety chase, pilot proficiency and aerial photography. Two SR-71 aircraft have been used by NASA as testbeds for high-speed and high-altitude aeronautical research. The aircraft, an SR-71A and an SR-71B pilot trainer aircraft, have been based here at NASA's Dryden Flight Research Center, Edwards, California. They were transferred to NASA after the U.S. Air Force program was cancelled. As research platforms, the aircraft can cruise at Mach 3 for more than one hour. For thermal experiments, this can produce heat soak temperatures of over 600 degrees Fahrenheit (F). This operating environment makes these aircraft excellent platforms to carry out research and experiments in a variety of areas -- aerodynamics, propulsion, structures, thermal protection materials, high-speed and high-temperature instrumentation, atmospheric studies, and sonic boom characterization. The SR-71 was used in a program to study ways of reducing sonic booms or over pressures that are heard on the ground, much like sharp thunderclaps, when an aircraft exceeds the speed of sound. Data from this Sonic Boom Mitigation Study could eventually lead to aircraft designs that would reduce the 'peak' overpressures of sonic booms and minimize the startling affect they produce on the ground. One of the first major experiments to be flown in the NASA SR-71 program was a laser air data collection system. It used laser light instead of air pressure to produce airspeed and attitude reference data, such as angle of attack and sideslip, which are normally obtained with small tubes and vanes extending into the airstream. One of Dryden's SR-71s was used

  17. Decoding Biosynthetic Pathways in Plants by Pulse-Chase Strategies Using 13CO2 as a Universal Tracer

    Directory of Open Access Journals (Sweden)

    Adelbert Bacher

    2016-07-01

    Full Text Available 13CO2 pulse-chase experiments monitored by high-resolution NMR spectroscopy and mass spectrometry can provide 13C-isotopologue compositions in biosynthetic products. Experiments with a variety of plant species have documented that the isotopologue profiles generated with 13CO2 pulse-chase labeling are directly comparable to those that can be generated by the application of [U-13C6]glucose to aseptically growing plants. However, the application of the 13CO2 labeling technology is not subject to the experimental limitations that one has to take into account for experiments with [U-13C6]glucose and can be applied to plants growing under physiological conditions, even in the field. In practical terms, the results of biosynthetic studies with 13CO2 consist of the detection of pairs, triples and occasionally quadruples of 13C atoms that have been jointly contributed to the target metabolite, at an abundance that is well above the stochastic occurrence of such multiples. Notably, the connectivities of jointly transferred 13C multiples can have undergone modification by skeletal rearrangements that can be diagnosed from the isotopologue data. As shown by the examples presented in this review article, the approach turns out to be powerful in decoding the carbon topology of even complex biosynthetic pathways.

  18. Douglas Lowy and Nirali Shah discuss advancements in cancer treatment at the second annual Chasing Cancer Summit | Center for Cancer Research

    Science.gov (United States)

    On Monday, September 18, 2017, the second annual Chasing Cancer Summit was held at the Washington Post headquarters in downtown Washington, D.C. The live event brought together a group of experts, including CCR’s Douglas Lowy, M.D., and Nirali Shah, M.D., for discussions on the latest developments in cancer detection and treatment.  Read more...

  19. Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug.

    Science.gov (United States)

    Larsen, A T; Holm, R; Müllertz, A

    2017-08-01

    In this study, the potential of co-administering an aqueous suspension with a placebo lipid vehicle, i.e. chase dosing, was investigated in rats relative to the aqueous suspension alone or a solution of the drug in the lipid vehicle. The lipid investigated in the present study was Labrafil M2125CS and three evaluated poorly soluble model compounds, danazol, cinnarizine and halofantrine. For cinnarizine and danazol the oral bioavailability in rats after chase dosing or dosing the compound dissolved in Labrafil M21515CS was similar and significantly higher than for the aqueous suspension. For halofantrine the chase dosed group had a tendency towards a low bioavailability relative to the Labrafil M2125CS solution, but still a significant higher bioavailability relative to the aqueous suspension. This could be due to factors such as a slower dissolution rate in the intestinal phase of halofantrine or a lower solubility in the colloidal structures formed during digestion, but other mechanisms may also be involved. The study thereby supported the potential of chase dosing as a potential dosing regimen in situations where it is beneficial to have a drug in the solid state, e.g. due to chemical stability issues in the lipid vehicle. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Short-term exposure to repeated chasing stress does not induce habituation in Senegalese sole, Solea senegalensis

    DEFF Research Database (Denmark)

    Conde-Sieira, Marta; Valente, Luisa M.P.; Hernandez-Perez, Juan

    2018-01-01

    Animals can habituate to certain repeated stressors and reduce the physiological response that such stressor evoked initially. Studies related to stress habituation in fish are scarce and the available data differ depending on the species and on the type, duration and severity of the stressor...... no significant changes in serotonergic activity. However, incremented serotonergic activity was detected in fish previously trained. Furthermore, dopaminergic activity decreased in diurnal trained and nocturnal trained groups with respect to ST/naïve fish. Crh expression in hypothalamus was higher in ST...... for the animals to habituate, indicating that repeated chasing within short periods should be avoided when manipulating fish in order to keep proper welfare conditions in this species....

  1. Temperature profiles from expendable bathythermograph (XBT) casts from the USCGC CHASE in the North Atlantic Ocean in support of the Integrated Global Ocean Services System (IGOSS) from 1974-02-26 to 1974-03-01 (NODC Accession 7400264)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — XBT data were collected from the USCGC CHASE in support of the Integrated Global Ocean Services System (IGOSS). Data were collected by the US Coast Guard from 26...

  2. Identificação de Paspalum notatum fluegge e Axonopus affinis chase através da análise de fragmentos foliares Identification of Paspalum notatum fluegge and Axonopus affinis chase through leaf fragments analysis

    Directory of Open Access Journals (Sweden)

    Maria Cláudia Lopes Nogueira

    1999-03-01

    Full Text Available Este trabalho teve como objetivo a caracterização e identificação de fragmentos foliares de Paspalum notatum Fluegge e Axonopus affinis Chase, como forma de subsidiar projetos de avaliação da dieta de animais fistulados. Para a caracterização das espécies, foram feitas várias coletas de folhas em áreas de pastagem natural do Campus da Universidade Federal de Santa Maria (RS, de maio de 1992 a junho de 1993. A diferenciação das espécies foi baseada no padrão de nervação, presença de pêlos e características do ápice e bordo foliar, observadas com auxílio de estereomicroscópio. A habilidade de um observador em identificar fragmentos das duas espécies numa mistura e a eficácia dos descritores foliares mencionados foram testadas através de análise estatística. Desta forma, foi constatado que o padrão de nervação é o melhor critério de diferenciação e que A. affinis difere de P. notatum, basicamente, pelo ápice foliar obtuso e pela presença de nervuras quaternárias. A análise estatística confirmou a capacidade do observador em reconhecer fragmentos das duas espécies.This research aimed at the characterization and identification of leaves, fragments of Paspalum notatum Fluegge and Axonopus affinis Chase, for future studies of diet evaluation of fistuleted animals. For the species characterization, several collections of leaves were made in native pasture areas at the UFSM Campus (Santa Maria, RS from May, 1992 to June, 1993. The differentiation of the species was based on the leave’s venation pattern, hair presence, leaf border and apex features, observed with a stereomicroscope. The obverver’s ability to identify the two species of leaves in a misture were tested with statistical analysis. It was observed that the venation pattern is the best characterization criteria and that A. affinis differs from P. notatum mainly by the obtuse leaf apex and by the quaternary vein presence. The statistical analysis

  3. Initiation of simian virus 40 DNA replication in vitro: Pulse-chase experiments identify the first labeled species as topologically unwound

    International Nuclear Information System (INIS)

    Bullock, P.A.; Seo, Yeon Soo; Hurwitz, J.

    1989-01-01

    A distinct unwound form of DNA containing the simian virus 40 (SV40) origin is produced in replication reactions carried out in mixtures containing crude fractions prepared from HeLa cells. This species, termed form U R , comigrates on chloroquine-containing agarose gels with the upper part of the previously described heterogeneous highly unwound circular DNA, form U. As with form U, formation of form U R is dependent upon the SV40 tumor (T) antigen. Pulse-chase experiments demonstrate that the first species to incorporate labeled deoxyribonucleotides comigrates with form U R . Restriction analyses of the products of the pulse-chase experiments show that initiation occurs at the SV40 origin and then proceeds outward in a bidirectional manner. These experiments establish form U R as the earliest detectable substrate for SV40 DNA replication and suggest that SV40 DNA replication initiates on an unwound species

  4. The regeneration of a multi-ethnic mixed-use area: The case of Robin Hood Chase

    Directory of Open Access Journals (Sweden)

    Ian Bentley

    1997-01-01

    Full Text Available Urban designers show increasing interest in promoting community participation in urban regeneration and especially housing regeneration. However, effective participation has proved difficult in multi-ethnic mixed-use areas, with their wide range of different (and often conflicting interest groups. This paper, presented in case-study form, analyses a project in one such area: the Robin Hood Chase local centre in St. Ann’s area of Nottingham. It pays particular attention to the identification of different interest groups and their associated institutions, the use of local media and social events to involve these groups in the urban design process, the use of rearrangeable models in a process of “enquiry by design”, and the production of a widely acceptable urban design strategy for the area. Analysis of feedback from participants indicates a high level of satisfaction both with the final physical design proposal and with the process itself; and also identifies directions for further development in the approach and techniques employed.

  5. Chasing the Mirage: a grounded theory of the clinical reasoning processes that Registered Nurses use to recognize delirium.

    Science.gov (United States)

    El Hussein, Mohamed; Hirst, Sandra

    2016-02-01

    The aim of this study was to construct a grounded theory that explains the clinical reasoning processes that registered nurses use to recognize delirium in older adults in acute care hospitals. Delirium is under-recognized in acute hospital settings, this may stem from underdeveloped clinical reasoning processes. Little is known about registered nurses' (RNs) clinical reasoning processes in complex situations such as delirium recognition. A grounded theory approach was used to analyse interview data about the clinical reasoning processes of RNs in acute hospital settings. Seventeen RNs were recruited. Concurrent data collection and comparative analysis and theoretical sampling were conducted in 2013-2014. The core category to emerge from the data was 'chasing the mirage', which describes RNs' clinical reasoning processes to recognize delirium during their interaction with older adults. Understanding the reasoning that contributes to delirium under-recognition provides a strategy by which, this problem can be brought to the forefront of RNs' awareness and intervention. Delirium recognition will contribute to quality care for older adults. © 2015 John Wiley & Sons Ltd.

  6. Costs of locomotion in polar bears: when do the costs outweigh the benefits of chasing down terrestrial prey?

    Science.gov (United States)

    Gormezano, Linda J; McWilliams, Scott R; Iles, David T; Rockwell, Robert F

    2016-01-01

    Trade-offs between locomotory costs and foraging gains are key elements in determining constraints on predator-prey interactions. One intriguing example involves polar bears pursuing snow geese on land. As climate change forces polar bears to spend more time ashore, they may need to expend more energy to obtain land-based food. Given that polar bears are inefficient at terrestrial locomotion, any extra energy expended to pursue prey could negatively impact survival. However, polar bears have been regularly observed engaging in long pursuits of geese and other land animals, and the energetic worth of such behaviour has been repeatedly questioned. We use data-driven energetic models to examine how energy expenditures vary across polar bear mass and speed. For the first time, we show that polar bears in the 125-235 kg size range can profitably pursue geese, especially at slower speeds. We caution, however, that heat build-up may be the ultimate limiting factor in terrestrial chases, especially for larger bears, and this limit would be reached more quickly with warmer environmental temperatures.

  7. Revival and emended description of 'Mycobacterium paraffinicum' Davis, Chase and Raymond 1956 as Mycobacterium paraffinicum sp. nov., nom. rev.

    Science.gov (United States)

    Toney, Nadege; Adekambi, Toidi; Toney, Sean; Yakrus, Mitchell; Butler, W Ray

    2010-10-01

    The omission of the name 'Mycobacterium paraffinicum' from the Approved Lists of Bacterial Names was due to phenotypic confusion surrounding a close relationship with Mycobacterium scrofulaceum. Correspondingly, 'M. paraffinicum' strains grew slowly in > 7 days, stained acid-alcohol-fast and produced yellow-pigmented, smooth, waxy colonies in the dark at an optimal temperature of 35°C. However, 'M. paraffinicum' strains demonstrated no activity for urease, nicotinamidase or pyrazinamidase and lacked growth at 42°C, unlike M. scrofulaceum. The mycolic acid pattern, as determined by HPLC, clustered 'M. paraffinicum' with M. scrofulaceum, Mycobacterium avium and Mycobacterium parascrofulaceum. Strains were fully susceptible to linezolid, rifabutin, clarithromycin and amikacin. Examination of the historical reference strain of 'M. paraffinicum', ATCC 12670, and five additional isolates using comparative studies with 16S rRNA, hsp65 and rpoB gene and concatenated sequences showed that they formed a tight taxonomic group that was distinct from similar non-tuberculous mycobacteria. Multilocus enzyme electrophoresis (MEE) analysis confirmed a close association of the five additional isolates with the reference strain of 'M. paraffinicum' with a genetic distance of 0.12 and showed that all six strains were distinct from other closely related species. These genetic results provided unambiguous evidence of the uniqueness of this slowly growing, scotochromogenic species and supported the revival of the name as Mycobacterium paraffinicum (ex Davis, Chase and Raymond 1956) sp. nov., nom. rev. We propose the previously deposited reference strain ATCC 12670(T) =DSM 44181(T) =NCIMB 10420(T), located in collections worldwide, as the type strain.

  8. Chasing a changing climate: Reproductive and dispersal traits predict how sessile species respond to global warming

    Science.gov (United States)

    Archambault, Jennifer M.; Cope, W. Gregory; Kwak, Thomas J.

    2018-01-01

    AimStudies of species' range shifts have become increasingly relevant for understanding ecology and biogeography in the face of accelerated global change. The combination of limited mobility and imperilled status places some species at a potentially greater risk of range loss, extirpation or extinction due to climate change. To assess the ability of organisms with limited movement and dispersal capabilities to track shifts associated with climate change, we evaluated reproductive and dispersal traits of freshwater mussels (Unionida), sessile invertebrates that require species‐specific fish for larval dispersal.LocationNorth American Atlantic Slope rivers.MethodsTo understand how unionid mussels may cope with and adapt to current and future warming trends, we identified mechanisms that facilitated their colonization of the northern Atlantic Slope river basins in North America after the Last Glacial Maximum. We compiled species occurrence and life history trait information for each of 55 species, and then selected life history traits for which ample data were available (larval brooding duration, host fish specificity, host infection strategy, and body size) and analysed whether the trait state for each was related to mussel distribution in Atlantic Slope rivers.ResultsBrooding duration (p  .10).Main conclusionsOur results are potentially applicable to many species for which life history traits have not been well‐documented, because reproductive and dispersal traits in unionid mussels typically follow phylogenetic relationships. These findings may help resource managers prioritize species according to climate change vulnerability and predict which species might become further imperilled with climate warming. Finally, we suggest that similar trait‐based decision support frameworks may be applicable for other movement limited taxa.

  9. Chasing the observational signatures of seed black holes at z > 7: candidate observability

    Science.gov (United States)

    Valiante, Rosa; Schneider, Raffaella; Zappacosta, Luca; Graziani, Luca; Pezzulli, Edwige; Volonteri, Marta

    2018-05-01

    Observing the light emitted by the first accreting black holes (BHs) would dramatically improve our understanding of the formation of quasars at z > 6, possibly unveiling the nature of their supermassive black hole (SMBH) seeds. In previous works, we explored the relative role of the two main competing BH seed formation channels, Population III remnants (low-mass seeds) and direct collapse BHs (high-mass seeds), investigating the properties of their host galaxies in a cosmological context. Building on this analysis, we predict here the spectral energy distribution and observational features of low- and high-mass BH seeds selected among the progenitors of a z ˜ 6 SMBH. We derive the processed emission from both accreting BHs and stars by using the photoionization code CLOUDY, accounting for the evolution of metallicity and dust-to-gas mass ratio in the interstellar medium of the host galaxies, as predicted by the cosmological data-constrained model GAMETE/QSODUST. We show how future missions like James Webb Space Telescope (JWST) and Advanced Telescope for High Energy Astrophysics (ATHENA) will be able to detect the light coming from SMBH progenitors already at z ˜ 16. We build upon previous complementary studies and propose a method based on the combined analysis of near-infrared colours, IR excess (IRX), and UV continuum slopes (i.e. colour-colour and IRX-β diagrams) to distinguish growing seed BH host galaxies from starburst-dominated systems in JWST surveys. Sources selected through this criterion would be the best target for follow-up X-ray observations.

  10. Finns det nån här? – Förmedling av paranormala fenomen i TV-serien Chasing the Dead

    OpenAIRE

    Heinänen, Thomas

    2013-01-01

    Genom denna kvalitativa innehållsanalys av TV-serien Chasing the Dead, undersöks på vilket sätt dokumenterade "bevis" på paranormala audiovisuella fenomen har presenterats av seriemakarna. Materialet analyseras med hjälp av forskningsresultat från, för denna TV-genre relevanta, studier av fenomen som Electronic Voice Phenomenon, Electro Magnetic Field, Orber. Biologiska fenomen som Apophenia och Pareidolia har tagits i beaktande då materialet har analyserats. Syftet med denna underso...

  11. EVALUATION OF PHYTOTOXIC EFFECT OF DELETERIOUS RHIZOBACTERIA ON THE ROOT GROWTH OF AXONOPUS AFFINIS (CHASE AND LENS ESCULENTA (MOENCH

    Directory of Open Access Journals (Sweden)

    X.J Pacheco-Hernández

    2015-11-01

    Full Text Available Las malezas ocasionan una gran pérdida en las tierras agrícolas y comúnmente, las medidas de manejo y contención de estas especies se dan con la aplicación de herbicidas, sin embargo; en años recientes se ha presentado un interés en establecer mecanismos de biocontrol seguros, con el empleo de bacterias inhibidoras del crecimiento conocidas como rizobacterias deletéreas (Deleterious rhizobacteria: DRBque se consideran generalmente como no parasíticas, y causan, de manera sutil, efectos deletéreos a través de la producción de metabolitos dañinos a las plantas. El presente trabajo tuvo como objetivo caracterizar la producción de ácido cianhídrico de pseudomonas rizobacterianas de malezas de un cultivo de alfalfa (Medicago sativa L. y evaluar el efecto fitotóxico de éstas sobre el crecimiento radical de plántulas de Axonopus affinis (Chase y Lens esculenta (Moench. De acuerdo con los resultados obtenidos con relación a la evidencia de que los aislados de pseudomonadas son rizobacterias cianogénicas y de su efecto fitotóxico medido sobre las especies vegetales bajo estudio; se sugieren a éstas como posibles agentes de biocontrol con pastos que sean considerados malezas; ya que en general se observó que inhiben su crecimiento radical; sin embargo, un enfoque particular lo tiene la rizobacteria Pseudomonas sp. A52, la cual presentó no solamente actividad como una DRB sino también como una rizobacteria promotora del crecimiento vegetal; lo que la hace más importante de analizar en cuanto a su potencial y espectro de acción; tanto para malezas monocotiledóneas como para dicotiledóneas, recomendable como un posible agente de biocontrol con actividad múltiple.

  12. Chase the direct impact of rainfall into groundwater in Mt. Fuji from multiple analyses including microbial DNA

    Science.gov (United States)

    Kato, Kenji; Sugiyama, Ayumi; Nagaosa, Kazuyo; Tsujimura, Maki

    2016-04-01

    A huge amount of groundwater is stored in subsurface environment of Mt. Fuji, the largest volcanic mountain in Japan. Based on the concept of piston flow transport of groundwater an apparent residence time was estimated to ca. 30 years by 36Cl/Cl ratio (Tosaki et al., 2011). However, this number represents an averaged value of the residence time of groundwater which had been mixed before it flushes out. We chased signatures of direct impact of rainfall into groundwater to elucidate the routes of groundwater, employing three different tracers; stable isotopic analysis (delta 18O), chemical analysis (concentration of silica) and microbial DNA analysis. Though chemical analysis of groundwater shows an averaged value of the examined water which was blended by various water with different sources and routes in subsurface environment, microbial DNA analysis may suggest the place where they originated, which may give information of the source and transport routes of the water examined. Throughout the in situ observation of four rainfall events showed that stable oxygen isotopic ratio of spring water and shallow groundwater obtained from 726m a.s.l. where the average recharge height of rainfall was between 1500 and 1800 m became higher than the values before a torrential rainfall, and the concentration of silica decreased after this event when rainfall exceeded 300 mm in precipitation of an event. In addition, the density of Prokaryotes in spring water apparently increased. Those changes did not appear when rainfall did not exceed 100 mm per event. Thus, findings shown above indicated a direct impact of rainfall into shallow groundwater, which appeared within a few weeks of torrential rainfall in the studied geological setting. In addition, increase in the density of Archaea observed at deep groundwater after the torrential rainfall suggested an enlargement of the strength of piston flow transport through the penetration of rainfall into deep groundwater. This finding was

  13. Characterization of the Photon Counting CHASE Jr., Chip Built in a 40-nm CMOS Process With a Charge Sharing Correction Algorithm Using a Collimated X-Ray Beam

    Energy Technology Data Exchange (ETDEWEB)

    Krzyżanowska, A. [AGH-UST, Cracow; Deptuch, G. W. [Fermilab; Maj, P. [AGH-UST, Cracow; Gryboś, P. [AGH-UST, Cracow; Szczygieł, R. [AGH-UST, Cracow

    2017-08-01

    This paper presents the detailed characterization of a single photon counting chip, named CHASE Jr., built in a CMOS 40-nm process, operating with synchrotron radiation. The chip utilizes an on-chip implementation of the C8P1 algorithm. The algorithm eliminates the charge sharing related uncertainties, namely, the dependence of the number of registered photons on the discriminator’s threshold, set for monochromatic irradiation, and errors in the assignment of an event to a certain pixel. The article presents a short description of the algorithm as well as the architecture of the CHASE Jr., chip. The analog and digital functionalities, allowing for proper operation of the C8P1 algorithm are described, namely, an offset correction for two discriminators independently, two-stage gain correction, and different operation modes of the digital blocks. The results of tests of the C8P1 operation are presented for the chip bump bonded to a silicon sensor and exposed to the 3.5- μm -wide pencil beam of 8-keV photons of synchrotron radiation. It was studied how sensitive the algorithm performance is to the chip settings, as well as the uniformity of parameters of the analog front-end blocks. Presented results prove that the C8P1 algorithm enables counting all photons hitting the detector in between readout channels and retrieving the actual photon energy.

  14. Real-time measurements of nitrogen oxide emissions from in-use New York City transit buses using a chase vehicle.

    Science.gov (United States)

    Shorter, Joanne H; Herndon, Scott; Zahniser, Mark S; Nelson, David D; Wormhoudt, Joda; Demerjian, Kenneth L; Kolb, Charles E

    2005-10-15

    New diesel engine technologies and alternative fuel engines are being introduced into fleets of mass transit buses to try to meet stricter emission regulations of nitrogen oxides and particulates: Real-time instruments including an Aerodyne Research tunable infrared laser differential absorption spectrometer (TILDAS) were deployed in a mobile laboratory to assess the impact of the implementation of the new technologies on nitrogen oxide emissions in real world driving conditions. Using a "chase" vehicle sampling strategy, the mobile laboratory followed target vehicles, repeatedly sampling their exhaust. Nitrogen oxides from approximately 170 in-use New York City mass transit buses were sampled during the field campaigns. Emissions from conventional diesel buses, diesel buses with continuously regenerating technology (CRT), diesel hybrid electric buses, and compressed natural gas (CNG) buses were compared. The chase vehicle sampling method yields real world emissions that can be included in more realistic emission inventories. The NO, emissions from the diesel and CNG buses were comparable. The hybrid electric buses had approximately one-half the NOx emissions. In CRT diesels, NO2 accounts for about one-third of the NOx emitted in the exhaust, while for non-CRT buses the NO2 fraction is less than 10%.

  15. OSQAR-CHASE Proposal

    CERN Document Server

    (Pugnat, P; (Sulc, M

    2015-01-01

    For 2015, the OSQAR collaboration will focus on a new proposal for the search of chameleon, a hypothetical scalar particle postulated as a dark energy candidate with an environment-dependant mass. The required experimental set-up has been successfully tested and validated in 2014 at the SM-18 experimental hall. This proposal will focus on the sensitivity that can be reached during the OSQAR chameleon run in 2015 as well as to possible upgrade phases of the experiment for the coming years.

  16. Chasing the Chinese Dream

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    People’s pursuit of better lives pushes the nation forward The belief that anyone can live a better life in the United States through hard workis called the American Dream. Many European settlers were drawn to the new continent by the American Dream.

  17. Chasing Unachievable Outcomes

    Science.gov (United States)

    Pangrazi, Robert P.

    2010-01-01

    Today, teachers complain about the lack of physical education time and the lack of physical education programming. In addition, a great deal of time is spent advocating the relationship between "healthy mind-healthy body." Today's drive to show a relationship between physical fitness/activity and academic achievement is really not different than…

  18. Cutting to the chase

    International Nuclear Information System (INIS)

    Snieckus, D.

    2001-01-01

    This article reports on the development of the cost effective abrasive cutting Sabre system which came as a result of UWG's work on the decommissioning of the Phillips' Maureen wells and adds to UWG's 'total severance solution' tools. The advantages of the system are highlighted and include the ability to operate from a platform or diving support vessel, to cut internal cases, and to eliminate the use of environmentally damaging explosives and the need to operate from a rig. The new Mark II version of the Sabre designed to work at greater depths of water, the range of the severance tools, UWG's well abandonment hole assembly system, and its aim to enter the Gulf of Mexico market are discussed. Details are given of the decommissioning of the Schwedeneck-See platforms in Kiel Bay off Germany and the Phillips' UK decommissioning plans for the Maureen platform

  19. Chasing the Dream

    Science.gov (United States)

    Gardezi, Aleena

    2012-01-01

    Community colleges are gearing up to play a greater role in providing open access and affordable education to undocumented immigrants since President Barack Obama's re-election, which ensured the continuance of his June 15th executive order offering deferred deportation to eligible young immigrants. That order provided an opportunity for children…

  20. Chasing a Moving Target: Perceptions of Work Readiness and Graduate Capabilities in Music Higher Research Degree Students

    Science.gov (United States)

    Harrison, Scott; Grant, Catherine

    2016-01-01

    Recent efforts to increase workplace readiness in university students have largely centred on undergraduates, with comparatively few strategies or studies focusing on higher research degree candidates. In the discipline of music, a wide diversity of possible career paths combined with rapidly changing career opportunities makes workplace readiness…

  1. An isotope approach based on C-13 pulse-chase labelling vs. the root trenching method to separate heterotrophic and autotrophic respiration in cultivated peatlands

    Energy Technology Data Exchange (ETDEWEB)

    Biasi, C.; Pitkamaki, A. S.; Tavi, N. M.; Koponen, H. T.; Martikainen, P. J. [Univ.of Eastern Finland, Kuopio (Finland). Dept. of Environmental Science], e-mail: christina.biasi@uef.fi

    2012-11-01

    We tested an isotope method based on C-13 pulse-chase labelling for determining the fractional contribution of soil microbial respiration to overall soil respiration in an organic soil (cutaway peatland, eastern Finland), cultivated with the bioenergy crop, reed canary grass. The plants were exposed to CO{sub 2}-13 for five hours and the label was thereafter determined in CO{sub 2} derived from the soil-root system. A two-pool isotope mixing model was used to separate sources of respiration. The isotopic approach showed that a minimum of 50% of the total CO{sub 2} originated from soil-microbial respiration. Even though the method uses undisturbed soil-plant systems, it has limitations concerning the experimental determination of the true isotopic signal of all components contributing to autotrophic respiration. A trenching experiment which was comparatively conducted resulted in a 71% fractional contribution of soil-microbial respiration. This value was likely overestimated. Further studies are needed to evaluate critically the output from these two partitioning approaches. (orig.)

  2. Forecast Combinations

    OpenAIRE

    Timmermann, Allan G

    2005-01-01

    Forecast combinations have frequently been found in empirical studies to produce better forecasts on average than methods based on the ex-ante best individual forecasting model. Moreover, simple combinations that ignore correlations between forecast errors often dominate more refined combination schemes aimed at estimating the theoretically optimal combination weights. In this paper we analyse theoretically the factors that determine the advantages from combining forecasts (for example, the d...

  3. A Novel Pulse-Chase SILAC Strategy Measures Changes in Protein Decay and Synthesis Rates Induced by Perturbation of Proteostasis with an Hsp90 Inhibitor

    Science.gov (United States)

    Fierro-Monti, Ivo; Racle, Julien; Hernandez, Celine; Waridel, Patrice; Hatzimanikatis, Vassily; Quadroni, Manfredo

    2013-01-01

    Standard proteomics methods allow the relative quantitation of levels of thousands of proteins in two or more samples. While such methods are invaluable for defining the variations in protein concentrations which follow the perturbation of a biological system, they do not offer information on the mechanisms underlying such changes. Expanding on previous work [1], we developed a pulse-chase (pc) variant of SILAC (stable isotope labeling by amino acids in cell culture). pcSILAC can quantitate in one experiment and for two conditions the relative levels of proteins newly synthesized in a given time as well as the relative levels of remaining preexisting proteins. We validated the method studying the drug-mediated inhibition of the Hsp90 molecular chaperone, which is known to lead to increased synthesis of stress response proteins as well as the increased decay of Hsp90 “clients”. We showed that pcSILAC can give information on changes in global cellular proteostasis induced by treatment with the inhibitor, which are normally not captured by standard relative quantitation techniques. Furthermore, we have developed a mathematical model and computational framework that uses pcSILAC data to determine degradation constants kd and synthesis rates Vs for proteins in both control and drug-treated cells. The results show that Hsp90 inhibition induced a generalized slowdown of protein synthesis and an increase in protein decay. Treatment with the inhibitor also resulted in widespread protein-specific changes in relative synthesis rates, together with variations in protein decay rates. The latter were more restricted to individual proteins or protein families than the variations in synthesis. Our results establish pcSILAC as a viable workflow for the mechanistic dissection of changes in the proteome which follow perturbations. Data are available via ProteomeXchange with identifier PXD000538. PMID:24312217

  4. A novel pulse-chase SILAC strategy measures changes in protein decay and synthesis rates induced by perturbation of proteostasis with an Hsp90 inhibitor.

    Directory of Open Access Journals (Sweden)

    Ivo Fierro-Monti

    Full Text Available Standard proteomics methods allow the relative quantitation of levels of thousands of proteins in two or more samples. While such methods are invaluable for defining the variations in protein concentrations which follow the perturbation of a biological system, they do not offer information on the mechanisms underlying such changes. Expanding on previous work [1], we developed a pulse-chase (pc variant of SILAC (stable isotope labeling by amino acids in cell culture. pcSILAC can quantitate in one experiment and for two conditions the relative levels of proteins newly synthesized in a given time as well as the relative levels of remaining preexisting proteins. We validated the method studying the drug-mediated inhibition of the Hsp90 molecular chaperone, which is known to lead to increased synthesis of stress response proteins as well as the increased decay of Hsp90 "clients". We showed that pcSILAC can give information on changes in global cellular proteostasis induced by treatment with the inhibitor, which are normally not captured by standard relative quantitation techniques. Furthermore, we have developed a mathematical model and computational framework that uses pcSILAC data to determine degradation constants kd and synthesis rates Vs for proteins in both control and drug-treated cells. The results show that Hsp90 inhibition induced a generalized slowdown of protein synthesis and an increase in protein decay. Treatment with the inhibitor also resulted in widespread protein-specific changes in relative synthesis rates, together with variations in protein decay rates. The latter were more restricted to individual proteins or protein families than the variations in synthesis. Our results establish pcSILAC as a viable workflow for the mechanistic dissection of changes in the proteome which follow perturbations. Data are available via ProteomeXchange with identifier PXD000538.

  5. Chasing the deal with the money: Measuring the required risk premium and expected abnormal returns of private equity funds to maximize their internal rate of return

    Directory of Open Access Journals (Sweden)

    Fernando Scarpati

    2013-09-01

    Full Text Available A number of scholars of private equity (“PE” have attempted to assess the ex-post returns, or performance, of PEs by adopting an ex-post perspective of asset pricing. In doing so a set of phenomena has been recognized that is thought to be specific to the PE sector, such as “money-chasing deal phenomenon” (Gompers and Lerner, 2000 and “performance persistence” (Lerner and Schoar, 2005. However, based on their continuing use of an ex-post perspective, few scholars have paid attention to the possible extent to which these and other PE phenomena may affect expected returns from PE investments. To address this problem this article draws on an ex-ante perspective of investment decision-making in suggesting how a number of drivers and factors of PE phenomena may produce “abnormal returns”, and that each of those drivers and factors should therefore be considered in accurately assessing the required risk premium and expected abnormal returns of PE investments. In making these contributions we examined a private equity investment of a regional PE in Italy and administered a telephone questionnaire to 40 PEs in Italy and the UK and found principally that while size is the most important driver in producing abnormal returns illiquidity alone cannot explain the expected returns of PE investments (cf. Franzoni et al., 2012. Based on our findings we developed a predictive model of PE decision-making that draws on an ex-ante perspective of asset pricing and takes into account PE phenomena and abnormal returns. This model extends the work of Franzoni et al. (2012, Jegadeesh et al. (2009, and Korteweg and Sorensen (2010 who did not consider the possible influence of PE phenomena in decision-making and will also help PE managers in making better-informed decisions.

  6. Chameleon Chasing II: A Replication.

    Science.gov (United States)

    Newsom, Doug A.; And Others

    1993-01-01

    Replicates a 1972 survey of students, educators, and Public Relations Society of America members regarding who the public relations counselor really serves. Finds that, in 1992, most respondents thought primary responsibility was to the client, then to the client's relevant publics, then to self, then to society, and finally to media. Compares…

  7. Biological Collections: Chasing the Ideal

    Science.gov (United States)

    Kamenski, P. A.; Sazonov, A. E.; Fedyanin, A. A.; Sadovnichy, V. A.

    2016-01-01

    This article is based on the results of an analysis of existing biological collections in Russia and abroad set up in the framework of the project “Scientific Basis of the National Biobank –Depository of Living Systems” by M.V. Lomonosov Moscow State University [1]. PMID:27437135

  8. CHASE Survey of Technology Needs

    Science.gov (United States)

    2017-03-01

    layers (system and application services) for some existing and emerging application domains and devices, for example, smartphones , cyber physical ...Also, this study shows that embedded systems security and cyber physical systems security is an emerging area of interest and importance. Keywords...hardware security; counterfeits; hardware Trojans; reverse engineering; embedded systems; cyber physical systems security. 1. Introduction Over the

  9. Captain Cook Chased a Chook

    Directory of Open Access Journals (Sweden)

    Katrina Schlunke

    2011-04-01

    Full Text Available How can we write the contemporary 'histories' of Captain Cook when they include such textual and material diversity? When that diversity ranges from children's rhymes to convenience stores as well as journals now claimed as iconic documents of the enlightenment? How might the insights of Bruno Latour into how the 'experimental' is produced in the laboratory be helpful in showing how Cook is produced in a settler culture? How does revealing the 'experimental' (the material and textual ethnography of history show us new ways of 'doing' history that engages with its textual as well as its material diversity.

  10. combination Dictionary

    African Journals Online (AJOL)

    rbr

    of the idiomatic expression as a whole" (Crystal 2003: 225-226). Idiomatic .... nations and idioms.11 Nonetheless, free combinations of words have not been .... those who thronged Emmett place last night wanted to see the film, and they.

  11. Winning Combinations

    DEFF Research Database (Denmark)

    Criscuolo, Paola; Laursen, Keld; Reichstein, Toke

    2018-01-01

    examine the effectiveness of different combinations of knowledge sources for achieving innovative performance. We suggest that combinations involving integrative search strategies – combining internal and external knowledge – are the most likely to generate product and process innovation. In this context......, we present the idea that cognitively distant knowledge sources are helpful for innovation only when used in conjunction with knowledge sources that are closer to the focal firm. We also find important differences between product and process innovation, with the former associated with broader searches......Searching for the most rewarding sources of innovative ideas remains a key challenge in management of technological innovation. Yet, little is known about which combinations of internal and external knowledge sources are triggers for innovation. Extending theories about searching for innovation, we...

  12. Forecast combinations

    OpenAIRE

    Aiolfi, Marco; Capistrán, Carlos; Timmermann, Allan

    2010-01-01

    We consider combinations of subjective survey forecasts and model-based forecasts from linear and non-linear univariate specifications as well as multivariate factor-augmented models. Empirical results suggest that a simple equal-weighted average of survey forecasts outperform the best model-based forecasts for a majority of macroeconomic variables and forecast horizons. Additional improvements can in some cases be gained by using a simple equal-weighted average of survey and model-based fore...

  13. Combined homicide

    Directory of Open Access Journals (Sweden)

    Slović Živana

    2017-01-01

    Full Text Available Introduction: Combined homicide is a combination of two or more different modes of killing. These homicides occur when multiple perpetrators have different mode of killing, to hide the true manner of death, or when an initially unsuccessful attack with one weapon is abandoned and changed by another mode which is more successful, or due to availability of weapons at the scene of homicide, or unexpected appearance of possible eyewitness, or else. Case report: This case report is about 65-year old woman who was found in her residence on the floor next to the bed lying on her back with two kitchen knives in her neck. Autopsy revealed an abrasion on the frontal part of the neck and a bruise of the soft tissues of the neck with a double fracture of both greater horns of the hyoid bone and a fracture of both superior horns of the thyroid cartilage. The cause of death was exsanguination into right half of the thoracic cavity from the left subclavian artery which was cut, on the spot of stab wound in the neck. Conclusion: Hemorrhage in the soft tissue near broken hyoid bone and thyroid cartilage indicate that the victim was first strangulated and then stabbed with kitchen knives. Combined homicides are caused by one or more killers in order to accelerate the killing, or to be sure to provide the fatal outcome. This case is also interesting because the killer left weapon in the victim's neck.

  14. Characterization of on-road vehicle emissions in the Mexico City Metropolitan Area using a mobile laboratory in chase and fleet average measurement modes during the MCMA-2003 field campaign

    Directory of Open Access Journals (Sweden)

    M. Zavala

    2006-01-01

    Full Text Available A mobile laboratory was used to measure on-road vehicle emission ratios during the MCMA-2003 field campaign held during the spring of 2003 in the Mexico City Metropolitan Area (MCMA. The measured emission ratios represent a sample of emissions of in-use vehicles under real world driving conditions for the MCMA. From the relative amounts of NOx and selected VOC's sampled, the results indicate that the technique is capable of differentiating among vehicle categories and fuel type in real world driving conditions. Emission ratios for NOx, NOy, NH3, H2CO, CH3CHO, and other selected volatile organic compounds (VOCs are presented for chase sampled vehicles in the form of frequency distributions as well as estimates for the fleet averaged emissions. Our measurements of emission ratios for both CNG and gasoline powered "colectivos" (public transportation buses that are intensively used in the MCMA indicate that – in a mole per mole basis – have significantly larger NOx and aldehydes emissions ratios as compared to other sampled vehicles in the MCMA. Similarly, ratios of selected VOCs and NOy showed a strong dependence on traffic mode. These results are compared with the vehicle emissions inventory for the MCMA, other vehicle emissions measurements in the MCMA, and measurements of on-road emissions in U.S. cities. We estimate NOx emissions as 100 600±29 200 metric tons per year for light duty gasoline vehicles in the MCMA for 2003. According to these results, annual NOx emissions estimated in the emissions inventory for this category are within the range of our estimated NOx annual emissions. Our estimates for motor vehicle emissions of benzene, toluene, formaldehyde, and acetaldehyde in the MCMA indicate these species are present in concentrations higher than previously reported. The high motor vehicle aldehyde emissions may have an impact on the photochemistry of urban areas.

  15. Combination with Tadalafil reduces the aphrodisiac activity of Cola ...

    African Journals Online (AJOL)

    Sexual behavioural parameters of mount latency, mount frequency, genital grooming, anogenital sniffing, and chasing of female animals were recorded in male rats (one hour after administration of extract) by their interaction with a receptive female (1:1) for an observatory period of 1 hour. Cola acuminata and Garcinia kola ...

  16. Cultivating Deductive Thinking with Angle Chasing

    Science.gov (United States)

    Edwards, Michael todd; Quinlan, James; Harper, Suzanne R.; Cox, Dana C.; Phelps, Steve

    2014-01-01

    Despite Common Core State Standards for Mathematics (CCSSI 2010) recommendations, too often students' introduction to proof consists of the study of formal axiomatic systems--for example, triangle congruence proofs--typically in an introductory geometry course with no connection back to previous work in earlier algebra courses. Van Hiele…

  17. Principal as Curriculum Leader: Chase Manhattan Project.

    Science.gov (United States)

    Petruzillo, Eileen; Scheinbart, Diane S.

    1986-01-01

    Describes a program initiated at a high school in New York City that identified learning styles of special education students in an effort to increase their achievement. Concludes that the program led to gains in motivation as well as achievement. Contains materials used to identify learning styles. (FL)

  18. Chasing brane inflation in string theory

    International Nuclear Information System (INIS)

    Krause, Axel; Pajer, Enrico

    2008-01-01

    We investigate the embedding of brane–antibrane inflation into a concrete type IIB string theory compactification with all moduli fixed. Specifically, we are considering a D3-brane, whose position represents the inflaton φ, in a warped conifold throat in the presence of supersymmetrically embedded D7-branes and an anti-D3-brane localized at the tip of the warped conifold cone. After presenting the moduli stabilization analysis for a general D7-brane embedding, we concentrate on two explicit models, the Ouyang and the Kuperstein embeddings. We analyze whether the forces induced by moduli stabilization and acting on the D3-brane might be canceled by fine-tuning so as to leave us with the original Coulomb attraction of the anti-D3-brane as the driving force for inflation. For a large class of D7-brane embeddings we obtain a negative result. Cancelations are possible only for very small intervals of φ around an inflection point and not globally. For the most part of its motion the inflaton then feels a steep, non-slow-roll potential. We study the inflationary dynamics induced by this potential

  19. Chasing the unicorn: RHIC and the QGP

    International Nuclear Information System (INIS)

    Pisarski, Robert D.; Niels Bohr Institute, Copenhagen; J. W. Goethe Univ., Frankfurt

    2006-01-01

    At nonzero temperature, it is expected that QCD undergoes a phase transition to a deconfined, chirally symmetric phase, the Quark-Gluon Plasma (QGP). I review what we expect theoretically about this possible transition, and what we have learned from heavy ion experiments at RHIC. I argue that while there are unambiguous signals for qualitatively new behavior at RHIC, versus experiments at lower energies, that in detail, no simple theoretical model can explain all salient features of the data. (author)

  20. Comparative Approaches to Genetic Discrimination: Chasing Shadows?

    Science.gov (United States)

    Joly, Yann; Feze, Ida Ngueng; Song, Lingqiao; Knoppers, Bartha M

    2017-05-01

    Genetic discrimination (GD) is one of the most pervasive issues associated with genetic research and its large-scale implementation. An increasing number of countries have adopted public policies to address this issue. Our research presents a worldwide comparative review and typology of these approaches. We conclude with suggestions for public policy development. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Chasing Aleck: the story of a dorm.

    Science.gov (United States)

    Edwards, R A R

    2007-01-01

    A student raised a hand in class and asked, "Why is this dorm named after Alexander Graham Bell?" On a deaf campus, this was a loaded question. Bell was an oralist, opposed to sign language. He was a eugenicist, opposed to deaf marriages. Indeed, the more I thought about it, the better this question got. Why did the school name a dormin after him? Unfortunately, I hadn't the foggiest idea. With apologies to that student, I offer this article as a belated answer.

  2. Chasing Lightning: Sferics, Tweeks and Whistlers

    Science.gov (United States)

    Webb, P. A.; Franzen, K.; Garcia, L.; Schou, P.; Rous, P.

    2008-12-01

    We all know what lightning looks like during a thunderstorm, but the visible flash we see is only part of the story. This is because lightning also generates light with other frequencies that we cannot perceive with our eyes, but which are just as real as visible light. Unlike the visible light from lightning, these other frequencies can carry the lightning's energy hundreds or thousands of miles across the surface of the Earth in the form of special signals called "tweeks" and "sferics". Some of these emissions can even travel tens of thousands of miles out into space before returning to the Earth as "whistlers". The INSPIRE Project, Inc is a non-profit scientific and educational corporation whose beginning mission was to bring the excitement of observing these very low frequency (VLF) natural radio waves emissions from lightning to high school students. Since 1989, INSPIRE has provided specially designed radio receiver kits to over 2,600 participants around the world to make observations of signals in the VLF frequency range. Many of these participants are using the VLF data they collect in very creative projects that include fiction, music and art exhibitions. During the Fall 2008 semester, the first INSPIRE based university-level course was taught at University of Maryland Baltimore County (UMBC) as part of its First-Year Seminar (FYS) series. The FYS classes are limited to 20 first-year students per class and are designed to create an active-learning environment that encourages student participation and discussion that might not otherwise occur in larger first-year classes. This presentation will cover the experiences gained from using the INSPIRE kits as the basis of a university course. This will include the lecture material that covers the basic physics of lightning, thunderstorms and the Earth's atmosphere, as well as the electronics required to understand the basic workings of the VLF kit. It will also cover the students assembly of the kit in an electronics lab (some soldering required!) and the subsequent field trips to local sites to listen for the sferics, tweeks and whistlers using the assembled kit, followed by data analysis and the writing of reports on the observations.

  3. Chasing Butterflies without a Net: Interpreting Cosmopolitanism

    Science.gov (United States)

    Hansen, David T.

    2010-01-01

    In this article, I map current conceptions of cosmopolitanism and sketch distinctions between the concept and humanism and multiculturalism. The differences mirror what I take to be a central motif of cosmopolitanism: the capacity to fuse reflective openness to the new with reflective loyalty to the known. This motif invites a reconsideration of…

  4. Chasing the unicorn: RHIC and the QGP

    Energy Technology Data Exchange (ETDEWEB)

    Pisarski, Robert D. [Brookhaven National Lab., Upton, NY (United States). Nuclear Theory and High Energy Theory Nuclear Theory Groups; Niels Bohr Institute, Copenhagen (Denmark); J. W. Goethe Univ., Frankfurt (Germany). Frankfurt Institute for Advanced Study

    2006-03-15

    At nonzero temperature, it is expected that QCD undergoes a phase transition to a deconfined, chirally symmetric phase, the Quark-Gluon Plasma (QGP). I review what we expect theoretically about this possible transition, and what we have learned from heavy ion experiments at RHIC. I argue that while there are unambiguous signals for qualitatively new behavior at RHIC, versus experiments at lower energies, that in detail, no simple theoretical model can explain all salient features of the data. (author)

  5. Chasing the cuprates with dilatonic dyons

    Energy Technology Data Exchange (ETDEWEB)

    Amoretti, Andrea [Department of Applied Mathematics and Theoretical Physics, University of Cambridge,Cambridge, CB3 OWA (United Kingdom); Baggioli, Matteo [Institut de Física d’Altes Energies (IFAE), Universitat Autònoma de Barcelona,The Barcelona Institute of Science and Technology,Campus UAB, 08193 Bellaterra (Barcelona) (Spain); Magnoli, Nicodemo [Dipartimento di Fisica, Università di Genova, and I.N.F.N. - Sezione di Genova,via Dodecaneso 33, I-16146, Genova (Italy); Musso, Daniele [Abdus Salam International Centre for Theoretical Physics (ICTP),Strada Costiera 11, I-34151 Trieste (Italy)

    2016-06-20

    Magnetic field and momentum dissipation are key ingredients in describing condensed matter systems. We include them in gauge/gravity and systematically explore the bottom-up panorama of holographic IR effective field theories based on bulk Einstein-Maxwell Lagrangians plus scalars. The class of solutions here examined appears insufficient to capture the phenomenology of charge transport in the cuprates. We analyze in particular the temperature scaling of the resistivity and of the Hall angle. Keeping an open attitude, we illustrate weak and strong points of the approach.

  6. Chasing Shadows in the Outer Solar System

    Science.gov (United States)

    2010-01-01

    1 Ancient Greek philosophers payed great attention to astronomy , and pro- duced a variety of theories to describe the motion of objects in the sky...in Physics and Astronomy Presented to the Faculties of the University of Pennsylvania in Partial Fulfillment of the Requirements for the degree of...know what matters! Popeye The work presented in Chapers 3, 4 & 5 was accomplished with the col- laboration of the entire TAOS team: C. Alcock (Harvard

  7. Birth control pills - combination

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/patientinstructions/000655.htm Birth control pills - combination To use the sharing features on ... both progestin and estrogen. What Are Combination Birth Control Pills? Birth control pills help keep you from ...

  8. Modifiable Combining Functions

    OpenAIRE

    Cohen, Paul; Shafer, Glenn; Shenoy, Prakash P.

    2013-01-01

    Modifiable combining functions are a synthesis of two common approaches to combining evidence. They offer many of the advantages of these approaches and avoid some disadvantages. Because they facilitate the acquisition, representation, explanation, and modification of knowledge about combinations of evidence, they are proposed as a tool for knowledge engineers who build systems that reason under uncertainty, not as a normative theory of evidence.

  9. Practical, general parser combinators

    NARCIS (Netherlands)

    A. Izmaylova (Anastasia); A. Afroozeh (Ali); T. van der Storm (Tijs)

    2016-01-01

    textabstractParser combinators are a popular approach to parsing where contextfree grammars are represented as executable code. However, conventional parser combinators do not support left recursion, and can have worst-case exponential runtime. These limitations hinder the expressivity and

  10. Trendwatch combining expert opinion

    NARCIS (Netherlands)

    Hendrix, E.M.T.; Kornelis, M.; Pegge, S.M.; Galen, van M.A.

    2006-01-01

    In this study, focus is on a systematic way to detect future changes in trends that may effect the dynamics in the agro-food sector, and on the combination of opinions of experts. For the combination of expert opinions, the usefulness of multilevel models is investigated. Bayesian data analysis is

  11. Effective Nutritional Supplement Combinations

    Science.gov (United States)

    Cooke, Matt; Cribb, Paul J.

    Few supplement combinations that are marketed to athletes are supported by scientific evidence of their effectiveness. Quite often, under the rigor of scientific investigation, the patented combination fails to provide any greater benefit than a group given the active (generic) ingredient. The focus of this chapter is supplement combinations and dosing strategies that are effective at promoting an acute physiological response that may improve/enhance exercise performance or influence chronic adaptations desired from training. In recent years, there has been a particular focus on two nutritional ergogenic aids—creatine monohydrate and protein/amino acids—in combination with specific nutrients in an effort to augment or add to their already established independent ergogenic effects. These combinations and others are discussed in this chapter.

  12. Secondary combined suicide pact.

    Science.gov (United States)

    Jayanth, S H; Girish Chandra, Y P; Hugar, Basappa S; Kainoor, Sunilkumar

    2014-03-01

    This article reports a combined suicide pact, where in a young couple; a 26 year old male and a 20 year old female committed suicide by using two methods. The couple had resorted to hanging and self-immolation to prevent failure of single method alone. In secondary combined suicides, several other methods of suicide are tried after the first method chosen has failed. It is primary combined suicide only when two or more methods are used simultaneously. Both types of combined suicide by one individual is well reported in the literature whereas the same by two persons together is rare. In this report, the deceased were disappointed lovers, poor and the family members were against their marriage. The investigation of scene, methods employed to commit suicide, autopsy findings and the interview with their relatives altogether suggested that it was a secondary combined suicide pact. Copyright © 2014 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  13. PUVA combination therapy.

    Science.gov (United States)

    Morison, W L

    1985-08-01

    Various adjunctive treatments are now frequently used in combination with PUVA therapy with the aims of limiting adverse effects, improving efficacy and decreasing the cost of treatment. In the management of psoriasis, PUVA plus retinoids, PUVA plus methotrexate and PUVA plus UVB phototherapy are the most frequently used combinations. PUVA plus topical corticosteroids and PUVA plus anthralin are also efficacious but adverse effects and poor acceptance by patients are limiting factors. Combinations of PUVA plus nitrogen mustard and ionizing radiation are used in mycosis fungoides to treat tumors and residual disease in secluded sites. In the management of photodermatoses with PUVA therapy, prednisone is often required to prevent exacerbation of disease. A combination of prednisone and PUVA therapy can also be useful in lichen planus and atopic eczema. The selection of a suitable combination treatment, will depend upon the preferences of the clinician, the disease being treated, and the characteristics of the patient.

  14. Optical Communications Channel Combiner

    Science.gov (United States)

    Quirk, Kevin J.; Quirk, Kevin J.; Nguyen, Danh H.; Nguyen, Huy

    2012-01-01

    NASA has identified deep-space optical communications links as an integral part of a unified space communication network in order to provide data rates in excess of 100 Mb/s. The distances and limited power inherent in a deep-space optical downlink necessitate the use of photon-counting detectors and a power-efficient modulation such as pulse position modulation (PPM). For the output of each photodetector, whether from a separate telescope or a portion of the detection area, a communication receiver estimates a log-likelihood ratio for each PPM slot. To realize the full effective aperture of these receivers, their outputs must be combined prior to information decoding. A channel combiner was developed to synchronize the log-likelihood ratio (LLR) sequences of multiple receivers, and then combines these into a single LLR sequence for information decoding. The channel combiner synchronizes the LLR sequences of up to three receivers and then combines these into a single LLR sequence for output. The channel combiner has three channel inputs, each of which takes as input a sequence of four-bit LLRs for each PPM slot in a codeword via a XAUI 10 Gb/s quad optical fiber interface. The cross-correlation between the channels LLR time series are calculated and used to synchronize the sequences prior to combining. The output of the channel combiner is a sequence of four-bit LLRs for each PPM slot in a codeword via a XAUI 10 Gb/s quad optical fiber interface. The unit is controlled through a 1 Gb/s Ethernet UDP/IP interface. A deep-space optical communication link has not yet been demonstrated. This ground-station channel combiner was developed to demonstrate this capability and is unique in its ability to process such a signal.

  15. Wood-plastic combination

    International Nuclear Information System (INIS)

    Schaudy, R.

    1978-02-01

    A review on wood-plastic combinations is given including the production (wood and plastic component, radiation hardening, curing), the obtained properties, present applications and prospects for the future of these materials. (author)

  16. Resonant High Power Combiners

    CERN Document Server

    Langlois, Michel; Peillex-Delphe, Guy

    2005-01-01

    Particle accelerators need radio frequency sources. Above 300 MHz, the amplifiers mostly used high power klystrons developed for this sole purpose. As for military equipment, users are drawn to buy "off the shelf" components rather than dedicated devices. IOTs have replaced most klystrons in TV transmitters and find their way in particle accelerators. They are less bulky, easier to replace, more efficient at reduced power. They are also far less powerful. What is the benefit of very compact sources if huge 3 dB couplers are needed to combine the power? To alleviate this drawback, we investigated a resonant combiner, operating in TM010 mode, able to combine 3 to 5 IOTs. Our IOTs being able to deliver 80 kW C.W. apiece, combined power would reach 400 kW minus the minor insertion loss. Values for matching and insertion loss are given. The behavior of the system in case of IOT failure is analyzed.

  17. Combining in Theory Building

    Directory of Open Access Journals (Sweden)

    Uolevi Lehtinen

    2013-07-01

    Full Text Available The objectives of this article strive to describe the idea and rationale of combining i.e. why, when and how to develop theoretically new combined approaches. Then business administration, especially marketing is used as a theoretical and empirical illustrative area. Methodology is inductive and deductive logic and in the empirical examples surveys, case analysis and utilization of secondary data. This article introduce a new promising way, in the long run, to develop new comprehensive approaches and even paradigms for different disciplines, subdisciplines and branches of subdiciplines. Therefore, the ultimate message of the article is to challenge the researchers to put the idea and rationale for combing to the test in their own research field and to build new combined and comprehensive approaches if possible in the field. This message is rather multidisciplinary concerning for example economics, social sciences and political sciences in addition to business administration.

  18. Combinators for Paraconsistent Attitudes

    DEFF Research Database (Denmark)

    Villadsen, Jørgen

    2001-01-01

    In order to analyse the semantics of natural language sentences a translation into a partial type logic using lexical and logical combinators is presented. The sentences cover a fragment of English with propositional attitudes like knowledge, belief and assertion. A combinator is a closed term...... used for embedded sentences expressing propositional attitudes, thereby allowing for inconsistency without explosion (also called paraconsistency), and is based on a few key equalities for the connectives giving four truth values (truth, falsehood, and undefinedness with negative and positive polarity...

  19. Combined PET/MRI

    DEFF Research Database (Denmark)

    Bailey, D. L.; Pichler, B. J.; Gückel, B.

    2015-01-01

    This paper summarises key themes and discussions from the 4th international workshop dedicated to the advancement of the technical, scientific and clinical applications of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) systems that was held in Tübingen, Germany, from...

  20. Combine Harvester Simulator

    DEFF Research Database (Denmark)

    Vilmann, Ole; Sørlie, James Arnold

    1999-01-01

    A simulator for training pilots in the operation of a modern high-tech combine harvester is presented. The new simulator application is based on DMI´s well-known DMS maritime simulator architecture. Two major challenges have been encountered in the development of the simulator: 1) interfacing the...

  1. ILSE combiner study

    International Nuclear Information System (INIS)

    Hahn, K.

    1994-03-01

    In a heavy ion inertial fusion (HIF) driver, the beam energy and current are increased several orders of magnitude from the injector to the final focus system. At low and high energy stages of the driver, electrostatic and magnetic focusing transport channels, respectively, can be used. At the electric-to-magnetic transition point, the beams may be combined to reduce the transverse dimensions of the system, which could have significant impact on the driver cost. In a presently envisioned combiner, four beams are brought together transversely into a single transport channel. A matching section follows the combiner in order to provide a smooth transition to the subsequent magnetic transport channel. This report summarizes a conceptual design study of possible combiner configurations for the proposed Introduction Linac Systems Experiment (ILSE). The conceptual design study includes subjects such as the expected technical difficulties, predicted emittance growth, particle loss, effect of geometric and chromatic aberrations, and the sensitivity of emittance growth on the initial beam position and angle errors

  2. Combined-cycle plants

    International Nuclear Information System (INIS)

    Valenti, M.

    1991-01-01

    This paper reports that as tougher emissions standards take hold throughout the industrialized world, manufacturers such as GE, Siemens, Foster Wheeler, and Asea Brown Boveri are designing advanced combined-cycle equipment that offers improved environmental performance without sacrificing power efficiency

  3. Propagating Class and Method Combination

    DEFF Research Database (Denmark)

    Ernst, Erik

    1999-01-01

    number of implicit combinations. For example, it is possible to specify separate aspects of a family of classes, and then combine several aspects into a full-fledged class family. The combination expressions would explicitly combine whole-family aspects, and by propagation implicitly combine the aspects...

  4. Combined radiotherapy-chemotherapy

    International Nuclear Information System (INIS)

    Steel, G.G.

    1989-01-01

    This paper presents the clinically confirmed benefits of combined chemotherapy-radiotherapy. They have been found in a small group of diseases that respond to chemotherapy alone. According to the author, only when a drug or drug combination has the ability to eradicate occult disease or substantially to reduce the size of objectively measurable disease is there likely to be an demonstrable benefit from its use in conjunction with radiotherapy. It is the author's belief that the immediate future lies in selecting drugs and patients in which a good chemotherapeutic response can be expected, avoiding drugs that seriously enhance radiation damage to normal tissues and keeping drug and radiation treatments far enough apart in time to minimize interactions

  5. Combination Chemotherapy for Influenza

    Directory of Open Access Journals (Sweden)

    Robert G. Webster

    2010-07-01

    Full Text Available The emergence of pandemic H1N1 influenza viruses in April 2009 and the continuous evolution of highly pathogenic H5N1 influenza viruses underscore the urgency of novel approaches to chemotherapy for human influenza infection. Anti-influenza drugs are currently limited to the neuraminidase inhibitors (oseltamivir and zanamivir and to M2 ion channel blockers (amantadine and rimantadine, although resistance to the latter class develops rapidly. Potential targets for the development of new anti-influenza agents include the viral polymerase (and endonuclease, the hemagglutinin, and the non-structural protein NS1. The limitations of monotherapy and the emergence of drug-resistant variants make combination chemotherapy the logical therapeutic option. Here we review the experimental data on combination chemotherapy with currently available agents and the development of new agents and therapy targets.

  6. Combined XRD and XAS

    International Nuclear Information System (INIS)

    Ehrlich, S.N.; Hanson, J.C.; Lopez Camara, A.; Barrio, L.; Estrella, M.; Zhou, G.; Si, R.; Khalid, S.; Wang, Q.

    2011-01-01

    X-ray diffraction (XRD) and X-ray absorption fine structure (XAFS) are complementary techniques for investigating the structure of materials. XRD probes long range order and XAFS probes short range order. We have combined the two techniques at one synchrotron beamline, X18A at the NSLS, allowing samples to be studied in a single experiment. This beamline will allow for coordinated measurements of local and long range structural changes in chemical transformations and phase transitions using both techniques.

  7. Transfer function combinations

    KAUST Repository

    Zhou, Liang; Schott, Mathias; Hansen, Charles

    2012-01-01

    Direct volume rendering has been an active area of research for over two decades. Transfer function design remains a difficult task since current methods, such as traditional 1D and 2D transfer functions, are not always effective for all data sets. Various 1D or 2D transfer function spaces have been proposed to improve classification exploiting different aspects, such as using the gradient magnitude for boundary location and statistical, occlusion, or size metrics. In this paper, we present a novel transfer function method which can provide more specificity for data classification by combining different transfer function spaces. In this work, a 2D transfer function can be combined with 1D transfer functions which improve the classification. Specifically, we use the traditional 2D scalar/gradient magnitude, 2D statistical, and 2D occlusion spectrum transfer functions and combine these with occlusion and/or size-based transfer functions to provide better specificity. We demonstrate the usefulness of the new method by comparing to the following previous techniques: 2D gradient magnitude, 2D occlusion spectrum, 2D statistical transfer functions and 2D size based transfer functions. © 2012 Elsevier Ltd.

  8. Transfer function combinations

    KAUST Repository

    Zhou, Liang

    2012-10-01

    Direct volume rendering has been an active area of research for over two decades. Transfer function design remains a difficult task since current methods, such as traditional 1D and 2D transfer functions, are not always effective for all data sets. Various 1D or 2D transfer function spaces have been proposed to improve classification exploiting different aspects, such as using the gradient magnitude for boundary location and statistical, occlusion, or size metrics. In this paper, we present a novel transfer function method which can provide more specificity for data classification by combining different transfer function spaces. In this work, a 2D transfer function can be combined with 1D transfer functions which improve the classification. Specifically, we use the traditional 2D scalar/gradient magnitude, 2D statistical, and 2D occlusion spectrum transfer functions and combine these with occlusion and/or size-based transfer functions to provide better specificity. We demonstrate the usefulness of the new method by comparing to the following previous techniques: 2D gradient magnitude, 2D occlusion spectrum, 2D statistical transfer functions and 2D size based transfer functions. © 2012 Elsevier Ltd.

  9. A coal combine

    Energy Technology Data Exchange (ETDEWEB)

    Wlachovsky, I; Bartos, J

    1980-02-15

    A design is presented for a coal combine, equipped with two drum operational units, on whose both ends of the upper surface of the body, two coal saws are mounted with the help of a lever system. These saws, found in an operational position, form a gap in the block of the coal block, which is not embraced by the drum operational unit. The coal block, found between the gap and the support, falls down onto the longwall scraper conveyor. The lever system of each coal saw is controlled by two hydraulic jacks. One of the jacks is mounted vertically on the facial wall of the body of the combine and is used for the hoisting for the required height of the horizontal arm of the lever, reinforced by one end in the hinge on the body of the combine. On the ''free'' end of that lever, a coal saw is mounted in a hinge-like fashion and which is connected by the hydraulic jack to the horizontal arm of the lever system. This hydraulic jack is used for the clamping of the coal saw to the face.

  10. Belladonna Alkaloid Combinations and Phenobarbital

    Science.gov (United States)

    Donnatal® Elixir (as a combination product containing Atropine, Hyoscyamine, Phenobarbital, Scopolamine) ... PB Hyos® Elixir (as a combination product containing Atropine, Hyoscyamine, Phenobarbital, Scopolamine)

  11. Coherent laser beam combining

    CERN Document Server

    Brignon, Arnaud

    2013-01-01

    Recently, the improvement of diode pumping in solid state lasers and the development of double clad fiber lasers have allowed to maintain excellent laser beam quality with single mode fibers. However, the fiber output power if often limited below a power damage threshold. Coherent laser beam combining (CLBC) brings a solution to these limitations by identifying the most efficient architectures and allowing for excellent spectral and spatial quality. This knowledge will become critical for the design of the next generation high-power lasers and is of major interest to many industrial, environme

  12. Combined radiochemotherapy. Review

    Energy Technology Data Exchange (ETDEWEB)

    Konecny, M; Mechl, Z [Onkologicky Ustav, Brno (Czechoslovakia). Betatronove Pracoviste

    1978-09-01

    Physical, chemical, biochemical and biological modifications are described of the radiation reaction. The biochemical modification with antimetabolites has so far been the one most frequently used in clinical oncology. It has not yet been clarified whether treatment should begin with irradiation or chemotherapy. Conclusions are presented of the study of simultaneous chemotherapy and radiotherapy applications, ie., the attempt at synchronization of the tumor population. The present-time existence of a great number of combined treatment plans is more a consequence of empirical data which have not yet been clinically confirmed.

  13. Structural load combinations

    International Nuclear Information System (INIS)

    Hwang, H.; Reich, M.; Ellingwood, B.; Shinozuka, M.

    1985-01-01

    This paper presents the latest results of the program entitled, ''Probability Based Load Combinations For Design of Category I Structures''. In FY 85, a probability-based reliability analysis method has been developed to evaluate safety of shear wall structures. The shear walls are analyzed using stick models with beam elements and may be subjected to dead load, live load and in-plane eqrthquake. Both shear and flexure limit states are defined analytically. The limit state probabilities can be evaluated on the basis of these limit states. Utilizing the reliability analysis method mentioned above, load combinations for the design of shear wall structures have been established. The proposed design criteria are in the load and resistance factor design (LRFD) format. In this study, the resistance factors for shear and flexure and load factors for dead and live loads are preassigned, while the load factor for SSE is determined for a specified target limit state probability of 1.0 x 10 -6 or 1.0 x 10 -5 during a lifetime of 40 years. 23 refs., 9 tabs

  14. Combining Boosted Global

    Directory of Open Access Journals (Sweden)

    Szidónia Lefkovits

    2011-06-01

    Full Text Available The domain of object detection presents a wide range of interest due to its numerous application possibilities especially real time applications. All of them require high detection rate correlated with short processing time. One of the most efficient systems, working with visual information, were presented in the publication of Viola et al. [1], [2].This detection system uses classifiers based on Haar-like separating features combined with the AdaBoost learning algorithm. The most important bottleneck of the system is the big number of false detections at high hit rate. In this paper we propose to overcome this disadvantage by using specialized parts classifiers. This aim comes from the observation that the target object does not resemble the false detections at all.The reason of this fact is the coding manner of Haar-like features which attend to handle image patches and neglect the edges and contours. In order to obtain a more robust classifier, a global aspect method is combined with a part-based method, having the goal to improve the performance of the detector without significant increase of the detection time.

  15. Structural load combinations

    International Nuclear Information System (INIS)

    Hwang, H.; Reich, M.; Ellingwood, B.; Shinozuka, M.

    1986-01-01

    This paper presents the latest results of the program entitled, ''Probability Based Load Combinations For Design of Category I Structures''. In FY 85, a probability-based reliability analysis method has been developed to evaluate safety of shear wall structures. The shear walls are analyzed using stick models with beam elements and may be subjected to dead load, live load and in-plane earthquake. Both shear and flexure limit states are defined analytically. The limit state probabilities can be evaluated on the basis of these limit states. Utilizing the reliability analysis method mentioned above, load combinations for the design of shear wall structures have been established. The proposed design criteria are in the load and resistance factor design (LRFD) format. In this study, the resistance factors for shear and flexure and load factors for dead and live loads are preassigned, while the load factor for SSE is determined for a specified target limit state probability of 1.0 x 10 -6 or 1.0 x 10 -5 during a lifetime of 40 years

  16. Investigation of Inter-Node B Macro Diversity for Single-Carrier Based Radio Access in Evolved UTRA Uplink

    Science.gov (United States)

    Kawai, Hiroyuki; Morimoto, Akihito; Higuchi, Kenichi; Sawahashi, Mamoru

    This paper investigates the gain of inter-Node B macro diversity for a scheduled-based shared channel using single-carrier FDMA radio access in the Evolved UTRA (UMTS Terrestrial Radio Access) uplink based on system-level simulations. More specifically, we clarify the gain of inter-Node B soft handover (SHO) with selection combining at the radio frame length level (=10msec) compared to that for hard handover (HHO) for a scheduled-based shared data channel, considering the gains of key packet-specific techniques including channel-dependent scheduling, adaptive modulation and coding (AMC), hybrid automatic repeat request (ARQ) with packet combining, and slow transmission power control (TPC). Simulation results show that the inter-Node B SHO increases the user throughput at the cell edge by approximately 10% for a short cell radius such as 100-300m due to the diversity gain from a sudden change in other-cell interference, which is a feature specific to full scheduled-based packet access. However, it is also shown that the gain of inter-Node B SHO compared to that for HHO is small in a macrocell environment when the cell radius is longer than approximately 500m due to the gains from hybrid ARQ with packet combining, slow TPC, and proportional fairness based channel-dependent scheduling.

  17. Combined Heat and Power

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    At their 2007 Summit in Heiligendamm, G8 leaders called on countries to 'adopt instruments and measures to significantly increase the share of combined heat and power (CHP) in the generation of electricity.' As a result, energy, economic, environmental and utility regulators are looking for tools and information to understand the potential of CHP and to identify appropriate policies for their national circumstances. This report forms the first part of the response. It includes answers to policy makers' questions about the potential economic, energy and environmental benefits of an increased policy commitment to CHP. It also includes for the first time integrated IEA data on global CHP installations, and analyses the benefits of increased CHP investment in the G8+5 countries. A companion report will be produced later in 2008 to document best practice policy approaches that have been used to expand the use of CHP in a variety of countries.

  18. Biomass Gasification Combined Cycle

    Energy Technology Data Exchange (ETDEWEB)

    Judith A. Kieffer

    2000-07-01

    Gasification combined cycle continues to represent an important defining technology area for the forest products industry. The ''Forest Products Gasification Initiative'', organized under the Industry's Agenda 2020 technology vision and supported by the DOE ''Industries of the Future'' program, is well positioned to guide these technologies to commercial success within a five-to ten-year timeframe given supportive federal budgets and public policy. Commercial success will result in significant environmental and renewable energy goals that are shared by the Industry and the Nation. The Battelle/FERCO LIVG technology, which is the technology of choice for the application reported here, remains of high interest due to characteristics that make it well suited for integration with the infrastructure of a pulp production facility. The capital cost, operating economics and long-term demonstration of this technology area key input to future economically sustainable projects and must be verified by the 200 BDT/day demonstration facility currently operating in Burlington, Vermont. The New Bern application that was the initial objective of this project is not currently economically viable and will not be implemented at this time due to several changes at and around the mill which have occurred since the inception of the project in 1995. The analysis shows that for this technology, and likely other gasification technologies as well, the first few installations will require unique circumstances, or supportive public policies, or both to attract host sites and investors.

  19. Combined approach for gynecomastia

    Directory of Open Access Journals (Sweden)

    El-Sabbagh, Ahmed Hassan

    2016-02-01

    Full Text Available Background: Gynecomastia is a deformity of male chest. Treatment of gynecomastia varied from direct surgical excision to other techniques (mainly liposuction to a combination of both. Skin excision is done according to the grade. In this study, experience of using liposuction adjuvant to surgical excision was described. Patients and methods: Between September 2012 and April 2015, a total of 14 patients were treated with liposuction and surgical excision through a periareolar incision. Preoperative evaluation was done in all cases to exclude any underlying cause of gynecomastia. Results: All fourteen patients were treated bilaterally (28 breast tissues. Their ages ranged between 13 and 33 years. Two patients were classified as grade I, and four as grade IIa, IIb or III, respectively. The first showed seroma. Partial superficial epidermolysis of areola occurred in 2 cases. Superficial infection of incision occurred in one case and was treated conservatively. Conclusion: All grades of gynecomastia were managed by the same approach. Skin excision was added to a patient that had severe skin excess with limited activity and bad skin complexion. No cases required another setting or asked for 2 opinion.

  20. Combined approach for gynecomastia.

    Science.gov (United States)

    El-Sabbagh, Ahmed Hassan

    2016-01-01

    Gynecomastia is a deformity of male chest. Treatment of gynecomastia varied from direct surgical excision to other techniques (mainly liposuction) to a combination of both. Skin excision is done according to the grade. In this study, experience of using liposuction adjuvant to surgical excision was described. Between September 2012 and April 2015, a total of 14 patients were treated with liposuction and surgical excision through a periareolar incision. Preoperative evaluation was done in all cases to exclude any underlying cause of gynecomastia. All fourteen patients were treated bilaterally (28 breast tissues). Their ages ranged between 13 and 33 years. Two patients were classified as grade I, and four as grade IIa, IIb or III, respectively. The first 3 patients showed seroma. Partial superficial epidermolysis of areola occurred in 2 cases. Superficial infection of incision occurred in one case and was treated conservatively. All grades of gynecomastia were managed by the same approach. Skin excision was added to a patient that had severe skin excess with limited activity and bad skin complexion. No cases required another setting or asked for 2(nd) opinion.

  1. Challenges of Combining Perspectives.

    Science.gov (United States)

    Sundvall, Maria; Titelman, David; Bäärnhielm, Sofie

    2018-02-23

    Asylum seekers have increased risk of suicide and suicidal behavior, with differences related to origin, gender, and age. There are barriers to communication in clinical encounters between asylum seekers and clinicians. There is insufficient knowledge about how communication in the clinical encounter affects the suicide risk in female asylum seekers. To explore the documented communication between female asylum-seeking suicide attempters and clinicians and how it affects treatment. The medical records of 18 asylum-seeking women who had attempted suicide were analyzed with content analysis. Communication between patients and clinicians was affected by: the unbearable realities of the women; difficulties for clinicians in decoding languages of distress, and understanding trauma and subjective meanings of suicide; challenges of combining patients' and clinicians' perspectives; and a sense of shared powerlessness. The medical records did not give direct access to the patient's experience, only to the patient as documented by the clinician. The results suggest that clinicians working with asylum seekers who have attempted suicide need to develop an understanding of social and cultural factors and of trauma issues. A question for further study is how an enhanced integration of context and subjectivity in psychiatric practice would equip clinicians for the specific challenges encountered.

  2. LIDAR COMBINED SCANNING UNIT

    Directory of Open Access Journals (Sweden)

    V. V. Elizarov

    2016-11-01

    Full Text Available Subject of Research. The results of lidar combined scanning unit development for locating leaks of hydrocarbons are presented The unit enables to perform high-speed scanning of the investigated space in wide and narrow angle fields. Method. Scanning in a wide angular field is produced by one-line scanning path by means of the movable aluminum mirror with a frequency of 20Hz and amplitude of 20 degrees of swing. Narrowband scanning is performed along a spiral path by the deflector. The deflection of the beam is done by rotation of the optical wedges forming part of the deflector at an angle of ±50. The control function of the scanning node is performed by a specialized software product written in C# programming language. Main Results. This scanning unit allows scanning the investigated area at a distance of 50-100 m with spatial resolution at the level of 3 cm. The positioning accuracy of the laser beam in space is 15'. The developed scanning unit gives the possibility to browse the entire investigated area for the time not more than 1 ms at a rotation frequency of each wedge from 50 to 200 Hz. The problem of unambiguous definition of the beam geographical coordinates in space is solved at the software level according to the rotation angles of the mirrors and optical wedges. Lidar system coordinates are determined by means of GPS. Practical Relevance. Development results open the possibility for increasing the spatial resolution of scanning systems of a wide range of lidars and can provide high positioning accuracy of the laser beam in space.

  3. Combined dyslipidemia in childhood.

    Science.gov (United States)

    Kavey, Rae-Ellen W

    2015-01-01

    Combined dyslipidemia (CD) is now the predominant dyslipidemic pattern in childhood, characterized by moderate-to-severe elevation in triglycerides and non-high-density lipoprotein cholesterol (non-HDL-C), minimal elevation in low-density lipoprotein cholesterol (LDL-C), and reduced HDL-C. Nuclear magnetic resonance spectroscopy shows that the CD pattern is represented at the lipid subpopulation level as an increase in small, dense LDL and in overall LDL particle number plus a reduction in total HDL-C and large HDL particles, a highly atherogenic pattern. In youth, CD occurs almost exclusively with obesity and is highly prevalent, seen in more than 40% of obese adolescents. CD in childhood predicts pathologic evidence of atherosclerosis and vascular dysfunction in adolescence and young adulthood, and early clinical cardiovascular events in adult life. There is a tight connection between CD, visceral adiposity, insulin resistance, nonalcoholic fatty liver disease, and the metabolic syndrome, suggesting an integrated pathophysiological response to excessive weight gain. Weight loss, changes in dietary composition, and increases in physical activity have all been shown to improve CD significantly in children and adolescents in short-term studies. Most importantly, even small amounts of weight loss are associated with significant decreases in triglyceride levels and increases in HDL-C levels with improvement in lipid subpopulations. Diet change focused on limitation of simple carbohydrate intake with specific elimination of all sugar-sweetened beverages is very effective. Evidence-based recommendations for initiating diet and activity change are provided. Rarely, drug therapy is needed, and the evidence for drug treatment of CD in childhood is reviewed. Copyright © 2015 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  4. Conceptual Combination During Sentence Comprehension

    Science.gov (United States)

    Swinney, David; Love, Tracy; Walenski, Matthew; Smith, Edward E.

    2008-01-01

    This experiment examined the time course of integration of modifier-noun (conceptual) combinations during auditory sentence comprehension using cross-modal lexical priming. The study revealed that during ongoing comprehension, there is initial activation of features of the noun prior to activation of (emergent) features of the entire conceptual combination. These results support compositionality in conceptual combination; that is, they indicate that features of the individual words constituting a conceptual combination are activated prior to combination of the words into a new concept. PMID:17576278

  5. Generator of combined logical signals

    International Nuclear Information System (INIS)

    Laviron, Andre; Berard, Claude.

    1982-01-01

    The invention concerns a generator of combined logical signals to form combinations of two outputs at logical level 1 and N-2 outputs at logical level 0, among N generator outputs. This generator is characterized in that it includes a set of N means for storing combinations. Means enable the N storage means to be loaded with the logical levels corresponding to a pre-set starting combination, to control the operations for shifting the contents of the storage means and to control, by transfer facilities, the transfers of contents between these storage means. Controls enable the storage means to be actuated in order to obtain combinations of logical levels 1 and 0. The generation of combinations can be stopped after another pre-set combination. Application is for testing of safety circuits for nuclear power stations [fr

  6. The Alkali/Surfactant/ Polymer Process: Effects of Slug Size, Core Length and a Chase Polymer Le procédé alkali/surfactant/polymère : effets de la taille du bouchon, de la longueur de la carotte et d'un polymère de déplacement

    Directory of Open Access Journals (Sweden)

    Green K. A.

    2006-11-01

    Full Text Available An experimental study was conducted to examine the effects of slug size, core length, and a chase polymer on the effectiveness of the alkali/surfactant/polymer (A/S/P process in recovering waterflood residual oil. Core flood experiments were conducted with unfired linear Berea sandstone cores. The tertiary oil recovery, oil cut, pressure drop, and chemical propagation were measured for each flood. Tertiary oil recovery significantly increased with the slug size up to 0. 5 of a pore volume. Increasing the slug size further resulted in a smaller incremental increase in oil recovery. A slight increase in tertiary oil recovery was obtained when small size A/S/P slugs were followed with achase polymer having a viscosity higher than the slug. The lack of oil recovery with small A/S/P slugs was due to the consumption and dilution of the injected chemicals, especially the synthetic surfactant, due to adsorption and dispersion. Increasing the core length by a factor of 4. 5 (from 9 to 40. 6 cm had no significant effect on tertiary oil recovery. Chemical propagation was found to be a function of core length (i. e. , core Peclet number and the size of the chase polymer slug. Increasing core length and employing a chase polymer maintained the integrity of the A/S/P slug by decreasing the effect of dispersion and minimizing the influence of viscous fingering at the tail of the A/S/P slug. Une étude expérimentale a été effectuée pour examiner les effets de la taille du bouchon, de la longueur de la carotte et de l'emploi d'un polymère de déplacement sur l'efficacité du procédé A/S/P (alkali/surfactant/polymère dans la récupération d'huile résiduelle par injection d'eau. Les expériences d'injection ont été faites avec des carottes rectilignes en grès de Berea vert. La récupération tertiaire du pétrole, la présence d'eau, la perte de charge et la propagation chimique ont été mesurées pour chaque injection. La récupération tertiaire du

  7. Packet reversed packet combining scheme

    International Nuclear Information System (INIS)

    Bhunia, C.T.

    2006-07-01

    The packet combining scheme is a well defined simple error correction scheme with erroneous copies at the receiver. It offers higher throughput combined with ARQ protocols in networks than that of basic ARQ protocols. But packet combining scheme fails to correct errors when the errors occur in the same bit locations of two erroneous copies. In the present work, we propose a scheme that will correct error if the errors occur at the same bit location of the erroneous copies. The proposed scheme when combined with ARQ protocol will offer higher throughput. (author)

  8. Combined Environment Acoustic Chamber (CEAC)

    Data.gov (United States)

    Federal Laboratory Consortium — Purpose: The CEAC imposes combined acoustic, thermal and mechanical loads on aerospace structures. The CEAC is employed to measure structural response and determine...

  9. Symbol Stream Combining Versus Baseband Combining for Telemetry Arraying

    Science.gov (United States)

    Divsalar, D.

    1983-01-01

    The objectives of this article are to investigate and analyze the problem of combining symbol streams from many Deep Space Network stations to enhance bit signal-to-noise ratio and to compare the performance of this combining technique with baseband combining. Symbol stream combining (SSC) has some advantages and some disadvantages over baseband combining (BBC). The SSC suffers almost no loss in combining the digital data and no loss due to the transmission of the digital data by microwave links between the stations. The BBC suffers 0.2 dB loss due to alignment and combining the IF signals and 0.2 dB loss due to transmission of signals by microwave links. On the other hand, the losses in the subcarrier demodulation assembly (SDA) and in the symbol synchronization assembly (SSA) for SSC are more than the losses in the SDA and SSA for BBC. It is shown that SSC outperforms BBC by about 0.35 dB (in terms of the required bit energy-to-noise spectral density for a bit error rate of 1,000) for an array of three DSN antennas, namely 64 m, 34m(T/R) and 34m(R).

  10. Revised Accounting for Business Combinations

    Science.gov (United States)

    Wilson, Arlette C.; Key, Kimberly

    2008-01-01

    The Financial Accounting Standards Board (FASB) has recently issued Statement of Financial Accounting Standards No. 141 (Revised 2007) Business Combinations. The object of this Statement is to improve the relevance, representational faithfulness, and comparability of reported information about a business combination and its effects. This Statement…

  11. Modified Aggressive Packet Combining Scheme

    International Nuclear Information System (INIS)

    Bhunia, C.T.

    2010-06-01

    In this letter, a few schemes are presented to improve the performance of aggressive packet combining scheme (APC). To combat error in computer/data communication networks, ARQ (Automatic Repeat Request) techniques are used. Several modifications to improve the performance of ARQ are suggested by recent research and are found in literature. The important modifications are majority packet combining scheme (MjPC proposed by Wicker), packet combining scheme (PC proposed by Chakraborty), modified packet combining scheme (MPC proposed by Bhunia), and packet reversed packet combining (PRPC proposed by Bhunia) scheme. These modifications are appropriate for improving throughput of conventional ARQ protocols. Leung proposed an idea of APC for error control in wireless networks with the basic objective of error control in uplink wireless data network. We suggest a few modifications of APC to improve its performance in terms of higher throughput, lower delay and higher error correction capability. (author)

  12. Uniportal anatomic combined unusual segmentectomies.

    Science.gov (United States)

    González-Rivas, Diego; Lirio, Francisco; Sesma, Julio

    2017-01-01

    Nowadays, sublobar anatomic resections are gaining momentum as a valid alternative for early stage lung cancer. Despite being technically demanding, anatomic segmentectomies can be performed by uniportal video-assisted thoracic surgery (VATS) approach to combine the benefits of minimally invasiveness with the maximum lung sparing. This procedure can be even more complex if a combined resection of multiple segments from different lobes has to be done. Here we report five cases of combined and unusual segmentectomies done by the same experienced surgeon in high volume institutions to show uniportal VATS is a feasible approach for these complex resections and to share an excellent educational resource.

  13. Combination contraceptives: effects on weight.

    Science.gov (United States)

    Gallo, Maria F; Lopez, Laureen M; Grimes, David A; Carayon, Florence; Schulz, Kenneth F; Helmerhorst, Frans M

    2014-01-29

    Weight gain is often considered a side effect of combination hormonal contraceptives, and many women and clinicians believe that an association exists. Concern about weight gain can limit the use of this highly effective method of contraception by deterring the initiation of its use and causing early discontinuation among users. However, a causal relationship between combination contraceptives and weight gain has not been established. The aim of the review was to evaluate the potential association between combination contraceptive use and changes in weight. In November 2013, we searched the computerized databases CENTRAL (The Cochrane Library), MEDLINE, POPLINE, EMBASE, and LILACS for studies of combination contraceptives, as well as ClinicalTrials.gov and International Clinical Trials Registry Platform (ICTRP). For the initial review, we also wrote to known investigators and manufacturers to request information about other published or unpublished trials not discovered in our search. All English-language, randomized controlled trials were eligible if they had at least three treatment cycles and compared a combination contraceptive to a placebo or to a combination contraceptive that differed in drug, dosage, regimen, or study length. All titles and abstracts located in the literature searches were assessed. Data were entered and analyzed with RevMan. A second author verified the data entered. For continuous data, we calculated the mean difference and 95% confidence interval (CI) for the mean change in weight between baseline and post-treatment measurements using a fixed-effect model. For categorical data, such as the proportion of women who gained or lost more than a specified amount of weight, the Peto odds ratio with 95% CI was calculated. We found 49 trials that met our inclusion criteria. The trials included 85 weight change comparisons for 52 distinct contraceptive pairs (or placebos). The four trials with a placebo or no intervention group did not find

  14. Mode Combinations and International Operations

    DEFF Research Database (Denmark)

    Benito, Gabriel R. G.; Petersen, Bent; Welch, Lawrence S.

    2011-01-01

    reveals that companies tend to combine modes of operation; thereby producing unique foreign operation mode “packages” for given activities and/or countries, and that the packages are liable to be modified over time – providing a potentially important optional path for international expansion. Our data...... key markets (China, UK and USA) as the basis for an exploration of the extent to which, and how and why, companies combine clearly different foreign operation modes. We examine their use of foreign operation mode combinations within given value activities as well as within given countries. The study...

  15. Mode Combinations and International Operations

    DEFF Research Database (Denmark)

    Benito, Gabriel R. G.; Petersen, Bent; Welch, Lawrence S.

    2011-01-01

    reveals that companies tend to combine modes of operation; thereby producing unique foreign operation mode “packages” for given activities and/or countries, and that the packages are liable to be modified over time—providing a potentially important optional path for international expansion. The data show...... markets (China, UK and USA) is used as the basis for an exploration of the extent to which, and how and why, companies combine clearly different foreign operation modes. We examine their use of foreign operation mode combinations within given value activities as well as within given countries. The study...

  16. Cut to the Chase: Editing Time and Space through Closed-Circuit Television Surveillance La fin des courses poursuites pour les policiers britanniques ? Le rôle de la vidéosurveillance dans le changement des représentations spatio-temporelles dans les courses poursuites

    Directory of Open Access Journals (Sweden)

    Daniel Neyland

    2011-10-01

    Full Text Available The UK is said to have the largest number of CCTV cameras of any European nation. These cameras have been involved in a variety of changes in UK police practices. Such changes range from new evidential practices in court cases, through access to new materials, to new questions posed regarding invasions of privacy. One unexplored area of police practices, which this paper will argue have undergone significant changes since the introduction of CCTV cameras, is police accountability. This paper will draw on recent controversies in the UK regarding police car chases to investigate the ways in which CCTV cameras have led to new and complex questions of police accountability.Le Royaume-Uni est souvent présenté comme le pays ayant le plus grand nombre de caméras en Europe. Ces caméras ont joué un rôle dans bien des changements intervenus au sein des pratiques de la police britannique, depuis la production de nouveaux types de preuves devant les tribunaux, en passant par l’accès à de nouveaux matériaux et à de nouvelles informations, jusqu’à la mise en lumière de nouvelles questions touchant aux violations de la vie privée. Un des aspects peu explorés parmi ces nouvelles pratiques policières concerne la question de la responsabilité et le fait, pour la police, de rendre des comptes. Cet article porte précisément sur les changements significatifs provoqués par l’introduction de caméras de vidéosurveillance dans la façon d’accomplir les activités policières. À partir du cas de controverses récentes au Royaume-Uni autour de courses poursuites dans lesquelles sont engagés des véhicules de police, il s’intéressera aux façons dont la présence et l’usage de caméras de vidéosurveillance ont amené des questions à la fois nouvelles et complexes, concernant la justification des actions de police.

  17. Combined keratoplasty and cataract extraction.

    Science.gov (United States)

    Demeler, U; Hinzpeter, E N

    1977-04-01

    A short film showing our technique of combined penetrating keratoplasty and intracapsular cataract extraction was shown, and the postoperative results in 72 eyes after an average of 3 years were reported.

  18. Atypical combinations and scientific impact.

    Science.gov (United States)

    Uzzi, Brian; Mukherjee, Satyam; Stringer, Michael; Jones, Ben

    2013-10-25

    Novelty is an essential feature of creative ideas, yet the building blocks of new ideas are often embodied in existing knowledge. From this perspective, balancing atypical knowledge with conventional knowledge may be critical to the link between innovativeness and impact. Our analysis of 17.9 million papers spanning all scientific fields suggests that science follows a nearly universal pattern: The highest-impact science is primarily grounded in exceptionally conventional combinations of prior work yet simultaneously features an intrusion of unusual combinations. Papers of this type were twice as likely to be highly cited works. Novel combinations of prior work are rare, yet teams are 37.7% more likely than solo authors to insert novel combinations into familiar knowledge domains.

  19. Autonomous grain combine control system

    Science.gov (United States)

    Hoskinson, Reed L.; Kenney, Kevin L.; Lucas, James R.; Prickel, Marvin A.

    2013-06-25

    A system for controlling a grain combine having a rotor/cylinder, a sieve, a fan, a concave, a feeder, a header, an engine, and a control system. The feeder of the grain combine is engaged and the header is lowered. A separator loss target, engine load target, and a sieve loss target are selected. Grain is harvested with the lowered header passing the grain through the engaged feeder. Separator loss, sieve loss, engine load and ground speed of the grain combine are continuously monitored during the harvesting. If the monitored separator loss exceeds the selected separator loss target, the speed of the rotor/cylinder, the concave setting, the engine load target, or a combination thereof is adjusted. If the monitored sieve loss exceeds the selected sieve loss target, the speed of the fan, the size of the sieve openings, or the engine load target is adjusted.

  20. Combining supramolecular chemistry with biology

    NARCIS (Netherlands)

    Uhlenheuer, D.A.; Petkau - Milroy, K.; Brunsveld, L.

    2010-01-01

    Supramolecular chemistry has primarily found its inspiration in biological molecules, such as proteins and lipids, and their interactions. Currently the supramolecular assembly of designed compounds can be controlled to great extent. This provides the opportunity to combine these synthetic

  1. Tariff Model for Combined Transport

    Directory of Open Access Journals (Sweden)

    Velimir Kolar

    2002-11-01

    Full Text Available By analysing the cwTen.t situation on the Croatian transportationmarket, and considering all parameters needed forthe development of combined transport, measures are suggestedin order to improve and stimulate its development. Oneof the first measures is the standardisation and introduction ofunique tariffs for combined transport, and then government incentivefor the organisation and development of combinedtransport means and equipment. A significant role in thisshould be set on adequately defined transport policy.

  2. Combining norms to prove termination

    DEFF Research Database (Denmark)

    Genaim, S.; Codish, M.; Gallagher, John Patrick

    2002-01-01

    Automatic termination analysers typically measure the size of terms applying norms which are mappings from terms to the natural numbers. This paper illustrates howt o enable the use of size functions defined as tuples of these simpler norm functions. This approach enables us to simplify the probl...... of the recursive data-types in the program, is often a suitable choice. We first demonstrate the power of combining norm functions and then the adequacy of combining norms based on regular types....

  3. Combined radar and telemetry system

    Energy Technology Data Exchange (ETDEWEB)

    Rodenbeck, Christopher T.; Young, Derek; Chou, Tina; Hsieh, Lung-Hwa; Conover, Kurt; Heintzleman, Richard

    2017-08-01

    A combined radar and telemetry system is described. The combined radar and telemetry system includes a processing unit that executes instructions, where the instructions define a radar waveform and a telemetry waveform. The processor outputs a digital baseband signal based upon the instructions, where the digital baseband signal is based upon the radar waveform and the telemetry waveform. A radar and telemetry circuit transmits, simultaneously, a radar signal and telemetry signal based upon the digital baseband signal.

  4. Author Details

    African Journals Online (AJOL)

    Mamat, K. Vol 9, No 5S (2017): Special Issue - Articles Performance of Multiple Error Correction (MEC) scheme based Hybrid ARQ (HARQ) algorithm for maximizing lifetime of Wireless Sensor Network (WSN) for natural disaster monitoring. Abstract PDF. ISSN: 1112-9867. AJOL African Journals Online. HOW TO USE AJOL.

  5. Author Details

    African Journals Online (AJOL)

    Bashah, S.K.. Vol 9, No 5S (2017): Special Issue - Articles Performance of Multiple Error Correction (MEC) scheme based Hybrid ARQ (HARQ) algorithm for maximizing lifetime of Wireless Sensor Network (WSN) for natural disaster monitoring. Abstract PDF. ISSN: 1112-9867. AJOL African Journals Online. HOW TO USE ...

  6. THROUGHPUT ANALYSIS OF EXTENDED ARQ SCHEMES

    African Journals Online (AJOL)

    PUBLICATIONS1

    ABSTRACT. Various Automatic Repeat Request (ARQ) schemes have been used to combat errors that befall in- formation transmitted in digital communication systems. Such schemes include simple ARQ, mixed mode ARQ and Hybrid ARQ (HARQ). In this study we introduce extended ARQ schemes and derive.

  7. Salamander colonization of Chase Lake, Stutsman County, North Dakota

    Science.gov (United States)

    Mushet, David M.; McLean, Kyle I.; Stockwell, Craig A.

    2013-01-01

    Salt concentrations in lakes are dynamic. In the western United States, water diversions have caused significant declines in lake levels resulting in increased salinity, placing many aquatic species at risk (Galat and Robinson 1983, Beutel et al. 2001). Severe droughts can have similar effects on salt concentrations and aquatic communities (Swanson et al. 2003). Conversely, large inputs of water can dilute salt concentrations and contribute to community shifts (Euliss et al. 2004).

  8. Cooperative and human aspects of software engineering: CHASE 2010

    DEFF Research Database (Denmark)

    Dittrich, Yvonne; Sharp, Helen C.; Winschiers Theophilus, Heike

    2010-01-01

    Software is created by people -- software engineers in cooperation with domain experts, users and other stakeholders--in varied environments, under various conditions. Thus understanding cooperative and human aspects of software development is crucial to comprehend how and which methods and tools...... are required, to improve the creation and maintenance of software. The 3rd workshop on Cooperative and Human Aspects of Software Engineering held at the International Conference on Software Engineering continued the tradition from earlier workshops and provided a lively forum to discuss current developments...... and high quality research in the field. Further dissemination of research results will lead to an improvement of software development and deployment across the globe....

  9. Cooperative and Human Aspects of Software Engineering (CHASE 2010)

    DEFF Research Database (Denmark)

    Dittrich, Yvonne; De Souza, Cleidson; Korpela, Mikko

    2010-01-01

    Software is created by people---software engineers---working in varied environments, under various conditions. Thus understanding cooperative and human aspect of software development is crucial to comprehend how methods and tools are used, and thereby improving the creation and maintenance...... research on human and cooperative aspects of software engineering. We aim at providing both a meeting place for the growing community and the possibility for researchers interested in joining the field to present their work in progress and get an overview over the field....... of software. Inspired by the hosting country's concept of co-responsibility -- ubuntu -- we especially invited contributions that address community-based development like open source development and sustainability of ICT eco-systems. The goal of this workshop is to provide a forum for discussing high quality...

  10. Defining Quality of Life: A Wild-Goose Chase?

    Directory of Open Access Journals (Sweden)

    Barbara Barcaccia

    2013-02-01

    Full Text Available In the last decades there has been a growing interest towards the concept of “Quality of Life” (QoL, not only in the bio-medical field, but also in other areas, such as sociology, psychology, economics, philosophy, architecture, journalism, politics, environment, sports, recreation, advertisements. Nevertheless QoL does turn out to be an ambiguous and elusive concept – a precise, clear and shared definition appears to be a long way off. In this article an analysis of how QoL is interpreted and defined in various scientific articles published in the last two decades, is offered. In addition, an illustration of how widespread the use of this concept is in different fields of knowledge, the difficulties in reaching a shared understanding of QoL, the problems involved in stating clearly the construct, and a presentation of some of its conceptualizations, are provided. The importance of subjectivity in the definition of what QoL is, emerges as a key aspect. This personal and subjective dimension could be the starting point for a more thorough and holistic understanding of this concept, in which standardized sets of valid, reliable and evidence-based measures of, e.g., psychological and spiritual dimensions, are encompassed in the person’s quality of life evaluation.

  11. NAEP and Policy: Chasing the Tail of the Assessment Tiger

    Science.gov (United States)

    Diket, Read M.; Brewer, Thomas M.

    2011-01-01

    This paper grabs hold of the "assessment tiger" by considering the history of the National Assessment of Educational Progress (NAEP) "Arts Report Cards" for the visual arts, which were constructed and have been administered four times within thirty-five years. Two purposes of the NAEP have persisted since its founding: (1)…

  12. Vaping on Instagram: cloud chasing, hand checks and product placement.

    Science.gov (United States)

    Chu, Kar-Hai; Allem, Jon-Patrick; Cruz, Tess Boley; Unger, Jennifer B

    2016-09-01

    This study documented images posted on Instagram of electronic cigarettes (e-cigarette) and vaping (activity associated with e-cigarette use). Although e-cigarettes have been studied on Twitter, few studies have focused on Instagram, despite having 500 million users. Instagram's emphasis on images warranted investigation of e-cigarettes, as past tobacco industry strategies demonstrated that images could be used to mislead in advertisements, or normalise tobacco-related behaviours. Findings should prove informative to tobacco control policies in the future. 3 months of publicly available data were collected from Instagram, including images and associated metadata (n=2208). Themes of images were classified as (1) activity , for example, a person blowing vapour; (2) product , for example, a personal photo of an e-cigarette device; (3) advertisement ; (4) text , for example, 'meme' or image containing mostly text and (5) other . User endorsement (likes) of each type of image was recorded. Caption text was analysed to explore different trends in vaping and e-cigarette-related text. Analyses found that advertisement -themed images were most common (29%), followed by product (28%), and activity (18%). Likes were more likely to accompany activity and product -themed images compared with advertisement or text -themed images (pInstagram affords its users the ability to post images of e-cigarette-related behaviours and gives advertisers the opportunity to display their product. Future research should incorporate novel data streams to improve public health surveillance, survey development and educational campaigns. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  13. Chasing storms in an agricultural catchment: the stream DOM story

    Science.gov (United States)

    Hernes, P. J.; Spencer, R. G.; Pellerin, B. A.; Downing, B. D.; Saraceno, J.; Dyda, R. Y.; Bergamaschi, B. A.

    2011-12-01

    Storm events are notorious for mobilizing large amounts of dissolved and particulate substances in streams and rivers. Conversion of natural landscapes to agricultural land-use can significantly amplify this effect. We investigated the impacts of two storm events on stream dissolved organic matter (DOM) in 2008 in Willow Slough, a California/Sacramento Valley agricultural catchment. The tools utilized included carbon stable isotopes, fluorescence, ultraviolet-visible absorbance, lignin, disinfection byproduct formation potential, and biodegradation experiments. Dissolved organic carbon (DOC) concentrations at the mouth at peak discharge during the storms ranged from 9-10 mg/L compared to baseline conditions of 2-4 mg/L. Other storm effects included increased dissolved organic nitrogen, depleted carbon stable isotopes, increased humic fluorescence intensity, increased specific UV absorbance (SUVA), decreased spectral slopes, increased bioavailability, and increased carbon-normalized yields of lignin. Increased frequency and intensity of storms due to climate change are likely to have a non-linear effect on riverine exports and water quality, with subsequent impacts on carbon loading, mercury transport, and drinking water quality.

  14. Scenes of Devastation: Chasing Hawaii's Deadly Ohia Fungus | Hawaii Public

    Science.gov (United States)

    Series Bytemarks Cafe The Body Show Series and Specials HPR Music Conversations Stargazer Helping Hand HPR Music HPR-1 / Jazz, blues, world HPR-2 / Your home for classical music Series and Specials Programs HPR-1 Schedule HPR-2 Schedule Programs A-Z Sponsored Series Events First Take with Science Friday

  15. A tutorial on hunting statistical significance by chasing N

    Directory of Open Access Journals (Sweden)

    Denes Szucs

    2016-09-01

    Full Text Available There is increasing concern about the replicability of studies in psychology and cognitive neuroscience. Hidden data dredging (also called p-hacking is a major contributor to this crisis because it substantially increases Type I error resulting in a much larger proportion of false positive findings than the usually expected 5%. In order to build better intuition to avoid, detect and criticise some typical problems, here I systematically illustrate the large impact of some easy to implement and so, perhaps frequent data dredging techniques on boosting false positive findings. I illustrate several forms of two special cases of data dredging. First, researchers may violate the data collection stopping rules of null hypothesis significance testing by repeatedly checking for statistical significance with various numbers of participants. Second, researchers may group participants post-hoc along potential but unplanned independent grouping variables. The first approach 'hacks' the number of participants in studies, the second approach ‘hacks’ the number of variables in the analysis. I demonstrate the high amount of false positive findings generated by these techniques with data from true null distributions. I also illustrate that it is extremely easy to introduce strong bias into data by very mild selection and re-testing. Similar, usually undocumented data dredging steps can easily lead to having 20-50%, or more false positives.

  16. Chasing Ambiguity: Critical Reflections on Working with Dance Graduates

    Science.gov (United States)

    Roe, Sarah

    2017-01-01

    This paper questions whether are we able to foster uncertainty and ambiguity within higher education arts programmes, specifically alongside current institutional demands and embedded pedagogies. If not, then what effect does this have on current dance graduates? I attend to these questions through critical reflections upon my work as a pedagogue,…

  17. Chasing "Ubuntu": Using ICTs to Promote Reflective Practice

    Science.gov (United States)

    Malone, Todd; Wilder, Hilary

    2008-01-01

    Purpose: To describe an exploratory study in which an online learning system was used to provide an intercultural experience for pre-service education students from New Jersey and Namibia. Design/methodology/approach: Pre-service education students from New Jersey and Namibia were enrolled in an online course in the fall of 2004. The following…

  18. Chasing the Clouds: Irradiance Variability and Forecasting for Photovoltaics

    NARCIS (Netherlands)

    Elsinga, B.

    2017-01-01

    The stochastic part of the variability of irradiance is captured through the variability of the clear-sky index. If variability is correlated for close locations, the aggregated PV-output will be relatively high compared to aggregate PV-output of locations that are far apart (and more likely to be

  19. A new type of coating to chase the clouds away

    CERN Multimedia

    Stefania Pandolfi

    2016-01-01

    The electron cloud problem needs to be addressed with innovative solutions, particularly in view of the rapidly approaching HL-LHC upgrade. CERN’s Vacuum, Surfaces and Coatings group has greatly improved its amorphous carbon coating technique, which is an alternative to the scrubbing process used so far. This technique is now fully mature and is being used for the vacuum chambers of the SPS magnets and the delicate beam screens of the LHC’s quadrupole triplets.   The violet light is produced by the argon plasma used when sputtering the amorphous carbon. The beam screen is coated in this case using the magnetic field of the quadrupole itself. (Image: Pedro Costa Pinto) We know that conditioning (or “scrubbing”) the beam pipe reduces the avalanche-like creation of secondary electrons from the tube’s walls, thus preventing the formation of unwanted electron clouds. But it has also been observed that scrubbing natur...

  20. Chasing the Rainbow: The Non-conscious Nature of Being

    Directory of Open Access Journals (Sweden)

    David A. Oakley

    2017-11-01

    Full Text Available Despite the compelling subjective experience of executive self-control, we argue that “consciousness” contains no top-down control processes and that “consciousness” involves no executive, causal, or controlling relationship with any of the familiar psychological processes conventionally attributed to it. In our view, psychological processing and psychological products are not under the control of consciousness. In particular, we argue that all “contents of consciousness” are generated by and within non-conscious brain systems in the form of a continuous self-referential personal narrative that is not directed or influenced in any way by the “experience of consciousness.” This continuously updated personal narrative arises from selective “internal broadcasting” of outputs from non-conscious executive systems that have access to all forms of cognitive processing, sensory information, and motor control. The personal narrative provides information for storage in autobiographical memory and is underpinned by constructs of self and agency, also created in non-conscious systems. The experience of consciousness is a passive accompaniment to the non-conscious processes of internal broadcasting and the creation of the personal narrative. In this sense, personal awareness is analogous to the rainbow which accompanies physical processes in the atmosphere but exerts no influence over them. Though it is an end-product created by non-conscious executive systems, the personal narrative serves the powerful evolutionary function of enabling individuals to communicate (externally broadcast the contents of internal broadcasting. This in turn allows recipients to generate potentially adaptive strategies, such as predicting the behavior of others and underlies the development of social and cultural structures, that promote species survival. Consequently, it is the capacity to communicate to others the contents of the personal narrative that confers an evolutionary advantage—not the experience of consciousness (personal awareness itself.

  1. Uric acid and chronic kidney disease: which is chasing which?

    Science.gov (United States)

    Johnson, Richard J.; Nakagawa, Takahiko; Jalal, Diana; Sánchez-Lozada, Laura Gabriela; Kang, Duk-Hee; Ritz, Eberhard

    2013-01-01

    Serum uric acid is commonly elevated in subjects with chronic kidney disease (CKD), but was historically viewed as an issue of limited interest. Recently, uric acid has been resurrected as a potential contributory risk factor in the development and progression of CKD. Most studies documented that an elevated serum uric acid level independently predicts the development of CKD. Raising the uric acid level in rats can induce glomerular hypertension and renal disease as noted by the development of arteriolosclerosis, glomerular injury and tubulointerstitial fibrosis. Pilot studies suggest that lowering plasma uric acid concentrations may slow the progression of renal disease in subjects with CKD. While further clinical trials are necessary, uric acid is emerging as a potentially modifiable risk factor for CKD. Gout was considered a cause of CKD in the mid-nineteenth century [1], and, prior to the availability of therapies to lower the uric acid level, the development of end-stage renal disease was common in gouty patients. In their large series of gouty subjects Talbott and Terplan found that nearly 100% had variable degrees of CKD at autopsy (arteriolosclerosis, glomerulosclerosis and interstitial fibrosis) [2]. Additional studies showed that during life impaired renal function occurred in half of these subjects [3]. As many of these subjects had urate crystals in their tubules and interstitium, especially in the outer renal medulla, the disease became known as gouty nephropathy. The identity of this condition fell in question as the presence of these crystals may occur in subjects without renal disease; furthermore, the focal location of the crystals could not explain the diffuse renal scarring present. In addition, many subjects with gout also had coexistent conditions such as hypertension and vascular disease, leading some experts to suggest that the renal injury in gout was secondary to these latter conditions rather than to uric acid per se [4]. Indeed, gout was removed from the textbooks as a cause of CKD, and the common association of hyperuricemia with CKD was solely attributed to the retention of serum uric acid that is known to occur as the glomerular filtration rate falls. Renewed interest in uric acid as a cause of CKD occurred when it was realized that invalid assumptions had been made in the arguments to dismiss uric acid as a risk factor for CKD [5]. The greatest assumption was that the mechanism by which uric acid would cause kidney disease would be via the precipitation as crystals in the kidney, similar to the way it causes gout. However, when laboratory animals with CKD were made hyperuricemic, the renal disease progressed rapidly despite an absence of crystals in the kidney [6]. Since this seminal study, there has been a renewed interest in the potential role uric acid may have in both acute and CKD. We briefly review some of the major advances that have occurred in this field in the last 15 years. PMID:23543594

  2. Chasing the College Dream in Hard Economic Times. Issue Brief

    Science.gov (United States)

    Buddin, Richard; Croft, Michelle

    2014-01-01

    Slow economic growth in the past several years has strained the financial resources of many American families and heightened financial burdens for families hoping to support their children's college education. These economic struggles come at a critical time for high school students who rely on family resources to fund large portions of college…

  3. Establishment of the Fox Chase Network Breast Cancer Risk Registry.

    Science.gov (United States)

    1995-10-01

    18 R eferences ................................................................................... . . 19 A ppendices ...Contact is made by phone I week after disclosure of test results to clarify issues and identify acute problems and intervene when appropriate. Follow... acutely and practice observations skills 1. Watch and listen for inconsistencies 2. Inappropriate comments and affect 3. Non-verbal communication 4

  4. Chase: Control of Heterogeneous Autonomous Sensors for Situational Awareness

    Science.gov (United States)

    2016-08-03

    modeling and processing, to de- velop nonparametric basis pursuit tools for sparse linear regression, nuclear norm regularization, and dictionary learning...pp. 112–125. 25 DISTRIBUTION A: Distribution approved for public release. [8] M. Mardani, G. Mateos, and G. B. Giannakis. “Distributed Nuclear Norm ...existing models and practice, we propose a new queueing model that cap - tures such cancellation delays. We then find how one can schedule redundant

  5. Vaping on Instagram: cloud chasing, hand checks and product placement

    Science.gov (United States)

    Chu, Kar-Hai; Allem, Jon-Patrick; Cruz, Tess Boley; Unger, Jennifer B

    2016-01-01

    Introduction This study documented images posted on Instagram of electronic cigarettes (e-cigarette) and vaping (activity associated with e-cigarette use). Although e-cigarettes have been studied on Twitter, few studies have focused on Instagram, despite having 500 million users. Instagram’s emphasis on images warranted investigation of e-cigarettes, as past tobacco industry strategies demonstrated that images could be used to mislead in advertisements, or normalise tobacco-related behaviours. Findings should prove informative to tobacco control policies in the future. Methods 3 months of publicly available data were collected from Instagram, including images and associated metadata (n=2208). Themes of images were classified as (1) activity, for example, a person blowing vapour; (2) product, for example, a personal photo of an e-cigarette device; (3) advertisement; (4) text, for example, ‘meme’ or image containing mostly text and (5) other. User endorsement (likes) of each type of image was recorded. Caption text was analysed to explore different trends in vaping and e-cigarette-related text. Results Analyses found that advertisement-themed images were most common (29%), followed by product (28%), and activity (18%). Likes were more likely to accompany activity and product-themed images compared with advertisement or text-themed images (pInstagram affords its users the ability to post images of e-cigarette-related behaviours and gives advertisers the opportunity to display their product. Future research should incorporate novel data streams to improve public health surveillance, survey development and educational campaigns. PMID:27660111

  6. International Conference on Metalorganic Vapor Chase Epitaxy (ICMOVPE) XVIII

    Energy Technology Data Exchange (ETDEWEB)

    Dupuis, Russell D. [Georgia Inst. of Technology, Atlanta, GA (United States)

    2017-05-05

    The ICMOVPE-XVIII conference created meaningful opportunities for intellectual challenge, networking opportunities, and intellectual stimulation for graduate students, Post-Doctoral Fellows and all attendees. This technical and social program further provided many opportunities for communication, brainstorming, and transfer of information as well as the development of collaborations across many institutions and companies. We had a significant number of members of underrepresented groups in STEM attending this conference. We also are publishing the proceedings of this conference with the Journal of Crystal Growth, a journal which receives wide electronic distribution in many academic institutions world-wide, making the technical information presented at ICMOVPE-XVIII have a much broader impact than would otherwise be possible. ICMOVPE XVIII had a total of 216 presentations and of these; there were 70 Student oral or poster presentations. The funds we obtained for student support from the Department of Energy were distributed among the registered students and Post Docs to supplement the full cost of registration of $1,100 each for regular registration to the reduced rate of at $850 each for graduate students and Post Docs.

  7. Snakes as hazards: modelling risk by chasing chimpanzees.

    Science.gov (United States)

    McGrew, William C

    2015-04-01

    Snakes are presumed to be hazards to primates, including humans, by the snake detection hypothesis (Isbell in J Hum Evol 51:1-35, 2006; Isbell, The fruit, the tree, and the serpent. Why we see so well, 2009). Quantitative, systematic data to test this idea are lacking for the behavioural ecology of living great apes and human foragers. An alternative proxy is snakes encountered by primatologists seeking, tracking, and observing wild chimpanzees. We present 4 years of such data from Mt. Assirik, Senegal. We encountered 14 species of snakes a total of 142 times. Almost two-thirds of encounters were with venomous snakes. Encounters occurred most often in forest and least often in grassland, and more often in the dry season. The hypothesis seems to be supported, if frequency of encounter reflects selective risk of morbidity or mortality.

  8. Chasing a consistent picture for dark matter direct detection searches

    NARCIS (Netherlands)

    Arina, C.

    2012-01-01

    In this paper we assess the present status of dark matter direct searches by means of Bayesian statistics. We consider three particle physics models for spin-independent dark matter interaction with nuclei: elastic, inelastic and isospin violating scattering. We briefly present the state of the art

  9. Chasing Heideggerian Circles: Freedom, Call, and Our Educational Ground

    Science.gov (United States)

    d'Agnese, Vasco

    2017-01-01

    Over the last couple of decades, Heideggerian philosophy has become an important resource for educationalists. A growing body of literature has demonstrated its educational potential, thus illumining pivotal educational features and phenomena. Whereas my research is situated in the critical space opened by this literature, I adopt a slightly…

  10. Chasing Perfection and Catching Excellence in Graduate Medical Education.

    Science.gov (United States)

    Andolsek, Kathryn M

    2015-09-01

    The author reflects on the chapter titled "Preserving Excellence in Residency Training and Medical Care" in Dr. Kenneth Ludmerer's book Let Me Heal: The Opportunity to Preserve Excellence in American Medicine. Rather than assuming that the status quo represents excellence, however, the author asserts that we must make an informed judgment regarding the quality of graduate medical education (GME) by applying an evidence-based approach, carefully measuring performance against specific criteria. But what are the right criteria to judge excellence in GME? The author posits that the first criterion for excellence is the foundational concept identified by the Josiah Macy Jr. Foundation, that of accountability to the public. The author argues that for GME to be truly excellent it must produce a workforce "of sufficient size, specialty mix, and skill" needed to serve the public good. For GME to be truly excellent it must produce the right composition (reflecting the population it serves), use the right pedagogy, and be embedded within the right clinical learning environment. Implementation of competency-based education must be bolder and accelerated. The process of culling out service from education in GME must be more honest, not because all service cannot in some ways be educational but because it is simply too expensive to squander a single minute of time in training. Finally, the epidemic of burnout must be addressed urgently and innovatively.

  11. Chasing Salmonella Typhimurium in free range egg production system.

    Science.gov (United States)

    Chousalkar, Kapil; Gole, Vaibhav; Caraguel, Charles; Rault, Jean-Loup

    2016-08-30

    Free range production systems are becoming a major source of egg production in Australia and worldwide. This study investigated shedding and ecology of Salmonella Typhimurium and Salmonella species in a free range layer flock, wild birds and foxes in the vicinity of the free range farm in different seasons. Shedding of Salmonella was significantly higher in summer. Within the shed, overall, Salmonella prevalence was highest in dust. Corticosterone level in faeces was highest in spring and lowest in winter. There was no direct association between the Salmonella shedding (MPN/gm) and corticosterone levels in faeces. Salmonella Typhimurium MLVA types isolated from fox and wild birds were similar to MLVA types isolated from layer flock and reported during human food borne illness. Wild birds and foxes appear to play an important role in S. Typhimurium ecology and food safety. Environmental factors could play a role in evolution of S. Typhimurium in free range environment. Crown Copyright © 2016. Published by Elsevier B.V. All rights reserved.

  12. Chasing Great Paths of Helmut “Oxidative Stress” Sies

    DEFF Research Database (Denmark)

    Majima, H.; Indo, H.; Nakanishi, I.

    2016-01-01

    Radical Research”. He has clarified our understanding of the causes of chronic developing diseases, and has studied antioxidant factors. In this article, importance of “Oxidative Stress” and our mitochondrial oxidative stress studies; roles of mitochondrial ROS, effects of vitamin E and its homologues...

  13. Movie prediction of lung tumor for precise chasing radiation therapy

    International Nuclear Information System (INIS)

    Chhatkuli, Ritu Bhusal; Demachi, Kazuyuki; Kawai, Masaki; Sakakibara, Hiroshi; Uesaka, Mitsuru

    2012-01-01

    In recent years, precision for radiation therapy is a major challenge in the field of cancer treatment. When it comes to a moving organ like lungs, limiting the radiation to the target and sparing the surrounding healthy tissue is always a concern. It can induce the limit in the accuracy of area irradiated during lung cancer radiation therapy. Many methods have been introduced to compensate the motion in order to reduce the effect of radiation to healthy tissue due to respiratory motion. The motion of lung along with the tumor makes it very difficult to spare the healthy tissue during radiation therapy. The fear of this unintended damage to the neighboring tissue often limits the dose that can be applied to the tumor. The purpose of this research is the prediction of future motion images for the improvement of tumor tracking method. We predict the motion images by using principal component analysis (PCA) and multi-channel singular spectral analysis (MSSA) method. Time series x-ray images are used as training images. The motion images were successfully predicted and verified using the developed algorithm. The real time implementation of this method in future is believed to be significant for higher level of real time tumor tracking during radiation therapy. (author)

  14. Chasing the limelight: Belgrade and Istanbul in the global competition

    Directory of Open Access Journals (Sweden)

    Stupar Aleksandra

    2006-01-01

    Full Text Available The purpose of this paper is to analyze and compare main changes of contemporary Belgrade and Istanbul - two urban nodes at the crossroads of different and multileveled flows. Following the same pattern of global activation, inevitable competition and networking, these cities are trying to synchronize their multidimensional background, establish new patterns of global behavior and adjust them to the dynamism of modern life. Consequently, their historical role has been modified, urban tissue has been developed, recreated and regenerated, and the output of this process represents an attractive testimony of their global initiation. Revealing the ambiguous nature of strong economic forces as well as a new fusion of urban cultures, Belgrade and Istanbul are structuring the globalized image with the new key-elements. However, their true potential and the real efficiency of this process should be re-evaluated - the changed physiognomy of the city could improve its position in the global hierarchy and facilitate its integration into the global community, but, sometimes, local limitations are too complex and too strong to be ignored.

  15. Environmental Rehabilitation of Closed Mines. A Chase Study on Romania

    Directory of Open Access Journals (Sweden)

    Bianca COBÂRZAN

    2008-02-01

    Full Text Available The present article attempts to analyze methods that can be used to restore a former coal mining site to a condition that is well integrated into its surroundings and that recovers the abandoned and contaminated land and renders its value to the community. The key concept that guides the present paper is that the coal mining is just a temporary land use and that the cost of cleaning the mining site should be an operating expense that has to be included in the budget of a coal mine company starting with the first year of operation. The coal mining industry in Romania is presented as a case study to emphasize the effects that closed coal mines have on communities where they are located and, based on the methods that are successfully used to solve similar problems, recommendations are formulated to improve the environmental rehabilitation of the mining sites.

  16. Chasing theta-13 with the Double Chooz experiment

    Energy Technology Data Exchange (ETDEWEB)

    Lasserre, Thierry [CEA/DSM/IRFU/SPP, Gif-sur-Yvette (France)

    2009-07-01

    Neutrino oscillation physics is entering a precision measurement area. The smallness of the theta-13 neutrino mixing angle is still enigmatic and should be resolved. Double Chooz will use two identical detectors near the Chooz nuclear power station to search for a non vanishing theta-13, and hopefully open the way to experiments aspiring to discover CP violation in the leptonic sector.

  17. Chasing {theta}{sub 13} with new reactor neutrino experiments

    Energy Technology Data Exchange (ETDEWEB)

    Lasserre, Th. [DSM/DAPNIA/SPP, CEA/Saclay, 91191 Gif-sur-Yvette (France)

    2005-12-15

    It is now widely accepted that a new middle baseline disappearance reactor neutrino experiment with multiple detectors could provide a clean measurement of the {theta}{sub 13} mixing angle, free from any parameter degeneracies and correlations induced by matter effect and the unknown leptonic Dirac CP phase. The current best constraint on the third mixing angle comes from the Chooz reactor neutrino experiment sin{sup 2}(2{theta}{sub 13})<0.2 (90 % C.L., {delta}m{sub atm}{sup 2}=2.010{sup -3} eV{sup 2}). Several projects of experiment, with different timescales, have been proposed over the last two years all around the world. Their sensitivities range from sin{sup 2}(2{theta}{sub 13})<0.01 to 0.03, having thus an excellent discovery potential of the {nu}{sub e} fraction of {nu}{sub 3}.

  18. Chasing Personal Meaning: Pedagogical Lessons through Luis Rodriguez's "Always Running"

    Science.gov (United States)

    Theisen-Homer, Victoria

    2014-01-01

    In this autobiographical narrative, the author recounts her experiences teaching the novel "Always Running" by Luis Rodriguez with her English classes at a high school in a gang-heavy area. When she first started teaching, this teacher struggled to engage students. One particularly disruptive student requested to read "Always…

  19. De geest uit de fles / Chasing the mind

    NARCIS (Netherlands)

    Lamme, V.A.F.

    2006-01-01

    The idea that we have a conscious mind, controlling our bodily actions, is deeply embedded in our thinking of human nature. But is this correct? In this essay I will take you along sleepwalking murderers, patients that have lost control over their actions, and frogs catching flies, to convince you

  20. Chasing zero: the drive to eliminate surgical site infections.

    Science.gov (United States)

    Thompson, Kristine M; Oldenburg, W Andrew; Deschamps, Claude; Rupp, William C; Smith, C Daniel

    2011-09-01

    It is estimated that healthcare associated infections (HAI) account for 1.7 million infections and 99,000 associated deaths each year, with annual direct medical costs of up to $45 billion. Surgical Site Infections (SSI) account for 17% of HAIs, an estimated annual cost of $3.5 to 10 billion for our country alone. This project was designed to pursue elimination of SSIs and document results. Starting in 2009 a program to eliminate SSIs was undertaken at a nationally recognized academic health center. Interventions already outlined by CMS and IHI were utilized, along with additional interventions based on literature showing relationships with SSI reduction and best practices. Rapid deployment of multiple interventions (SSI Bundle) was undertaken. Tactics included standardized order sets, a centralized preoperative evaluation (POE) clinic, high compliance with intraoperative interventions, and widespread monthly reporting of compliance and results. Data from 2008 to 2010 were collected and analyzed. Between May 1, 2008 and June 30, 2010, all patients with Class I and Class II wounds were tracked for SSIs. Baseline data (May-June 2008) was obtained showing a Class I surgical site infection rate of 1.78%, Class II of 2.82% (total surgical volume: 4160 cases). As of the second quarter 2010, those rates have dropped to 0.51% and 1.44%, respectively (P cost savings of nearly $1 million during the study period. Committed leadership, aggressive assurance of high compliance with multiple known interventions (SSI Bundle), transparency to achieve high levels of staff engagement, and centralization of critical surgical activities result in significant declines in SSIs with resulting substantial cost savings.

  1. Chasing Success: Air Force Efforts to Reduce Civilian Harm

    Science.gov (United States)

    2016-03-01

    movement harnessed impressions of airpower’s devastation to a broader critique of US engagement in Vietnam. Bernard Fall de- scribed the use of US ...the critique of US actions freights the exchange with a defense of respective legal positions. Second, the democratization of IHL has brought legal...shelter, watching. . . . For the first time in the war, Western television cameras filmed without censorship .”34 A journalist de- scribed the horrifying

  2. Establishment of the Fox Chase Network Breast Cancer Risk Registry

    Science.gov (United States)

    1996-10-01

    related to caner also are d ed. breast cancer. Participants learn about screening guidelines and prevention options. The Cancer Center Eligibility...ever treated with a series of x-rays to the front of your neck for acne, neck tumor or any other reason? (This does not include routine screening x-rays...hysterectomy (surgical removal of the uterus )? 10] Yes CONTINUE 20 No CONTINUE 80 Don’t know CONTINUE a. If yes, how old were you? (-) years 10. Have

  3. Food irradiation and combination processes

    International Nuclear Information System (INIS)

    Campbell-Platt, G.; Grandison, A.S.

    1990-01-01

    International approval of food irradiation is being given for the use of low and medium doses. Uses are being permitted for different categories of foods with maximum levels being set between 1 and 10 kGy. To maximize the effectiveness of these mild irradiation treatments while minimizing any organoleptic quality changes, combination processes of other technologies with irradiation will be useful. Combinations most likely to be exploited in optimal food processing include the use of heat, low temperature, and modified-atmosphere packaging. Because irradiation does not have a residual effect, the food packaging itself becomes an important component of a successful process. These combination processes provide promising alternatives to the use of chemical preservatives or harsher processing techniques. (author)

  4. Combined oral contraceptives: venous thrombosis.

    Science.gov (United States)

    de Bastos, Marcos; Stegeman, Bernardine H; Rosendaal, Frits R; Van Hylckama Vlieg, Astrid; Helmerhorst, Frans M; Stijnen, Theo; Dekkers, Olaf M

    2014-03-03

    Combined oral contraceptive (COC) use has been associated with venous thrombosis (VT) (i.e., deep venous thrombosis and pulmonary embolism). The VT risk has been evaluated for many estrogen doses and progestagen types contained in COC but no comprehensive comparison involving commonly used COC is available. To provide a comprehensive overview of the risk of venous thrombosis in women using different combined oral contraceptives. Electronic databases (Pubmed, Embase, Web of Science, Cochrane, CINAHL, Academic Search Premier and ScienceDirect) were searched in 22 April 2013 for eligible studies, without language restrictions. We selected studies including healthy women taking COC with VT as outcome. The primary outcome of interest was a fatal or non-fatal first event of venous thrombosis with the main focus on deep venous thrombosis or pulmonary embolism. Publications with at least 10 events in total were eligible. The network meta-analysis was performed using an extension of frequentist random effects models for mixed multiple treatment comparisons. Unadjusted relative risks with 95% confidence intervals were reported.Two independent reviewers extracted data from selected studies. 3110 publications were retrieved through a search strategy; 25 publications reporting on 26 studies were included. Incidence of venous thrombosis in non-users from two included cohorts was 0.19 and 0.37 per 1 000 person years, in line with previously reported incidences of 0,16 per 1 000 person years. Use of combined oral contraceptives increased the risk of venous thrombosis compared with non-use (relative risk 3.5, 95% confidence interval 2.9 to 4.3). The relative risk of venous thrombosis for combined oral contraceptives with 30-35 μg ethinylestradiol and gestodene, desogestrel, cyproterone acetate, or drospirenone were similar and about 50-80% higher than for combined oral contraceptives with levonorgestrel. A dose related effect of ethinylestradiol was observed for gestodene

  5. Planned combined radiotherapy and surgery

    International Nuclear Information System (INIS)

    Silverman, C.L.; Marks, J.E.

    1987-01-01

    Though the planned combined use of surgery and radiation has been shown to be beneficial for other tumors, the authors feel that the present evidence is far from persuasive in demonstrating a definite superiority of combined therapy over surgery or radiation alone for advanced laryngeal tumors. The actuarial or disease-free survival rates for patients treated with combined therapy have not been significantly increased over those obtained with a single modality in any randomized, well-controlled study, although the trend is toward improved local regional control. Many of the retrospective studies are probably flawed by selection bias; the patients selected for combined treatment generally have more advanced cancers and represent a worse prognostic group. It is clear from this review that the positive value of irradiation for advanced transglottic and supraglottic tumors needs to be documented by a controlled study that compares surgery alone with salvage radiation at time of recurrence to surgery plus adjuvant radiation. The authors feel that such a study is needed to put to rest the present controversy before they can advocate a course of treatment that is expensive, time-consuming, and difficult for the patients to tolerate owing to severe acute side effects and potentially morbid late effects (xerostomia, necrosis) that can greatly lessen the quality of life for these patients

  6. SUPPLEMENTARY INFORMATION A combined Electrochemical ...

    Indian Academy of Sciences (India)

    DELL

    A combined Electrochemical and Theoretical study of pyridine-based Schiff bases as novel corrosion inhibitors for mild steel in hydrochloric acid medium. PARUL DOHAREa, M A QURAISHIb* and I B OBOTb. aDepartment of Chemistry, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar. Pradesh 221 ...

  7. Combination Chemoprevention with Grape Antioxidants

    OpenAIRE

    Singh, Chandra K.; Siddiqui, Imtiaz A.; El-Abd, Sabah; Mukhtar, Hasan; Ahmad, Nihal

    2016-01-01

    Antioxidant ingredients present in grape have been extensively investigated for their cancer chemopreventive effects. However, much of the work has been done on individual ingredients, especially focusing on resveratrol and quercetin. Phytochemically, whole grape represents a combination of numerous phytonutrients. Limited research has been done on the possible synergistic/additive/antagonistic interactions among the grape constituents. Among these phytochemical constituents of grapes, resver...

  8. Combining Paraconsistent Logic with Argumentation

    NARCIS (Netherlands)

    Grooters, Diana; Prakken, Hendrik

    2014-01-01

    One tradition in the logical study of argumentation is to allow for arguments that combine strict and defeasible inference rules, and to derive the strict inference rules from a logic at least as strong as classical logic. An unsolved problem in this tradition is how the trivialising effect of the

  9. Combination treatment of neuropathic pain

    DEFF Research Database (Denmark)

    Holbech, Jakob Vormstrup; Jung, Anne; Jonsson, Torsten

    2017-01-01

    BACKGROUND: Current Danish treatment algorithms for pharmacological treatment of neuropathic pain (NeP) are tricyclic antidepressants (TCA), gabapentin and pregabalin as first-line treatment for the most common NeP conditions. Many patients have insufficient pain relief on monotherapy, but combin...

  10. Methodology for combining dynamic responses

    International Nuclear Information System (INIS)

    Cudlin, R.; Hosford, S.; Mattu, R.; Wichman, K.

    1978-09-01

    The NRC has historically required that the structural/mechanical responses due to various accident loads and loads caused by natural phenomena, (such as earthquakes) be combined when analyzing structures, systems, and components important to safety. Several approaches to account for the potential interaction of loads resulting from accidents and natural phenomena have been used. One approach, the so-called absolute or linear summation (ABS) method, linearly adds the peak structural responses due to the individual dynamic loads. In general, the ABS method has also reflected the staff's conservative preference for the combination of dynamic load responses. A second approach, referred to as SRSS, yields a combined response equal to the square root of the sum of the squares of the peak responses due to the individual dynamic loads. The lack of a physical relationship between some of the loads has raised questions as to the proper methodology to be used in the design of nuclear power plants. An NRR Working Group was constituted to examine load combination methodologies and to develop a recommendation concerning criteria or conditions for their application. Evaluations of and recommendations on the use of the ABS and SRSS methods are provided in the report

  11. Combined enteral and parenteral nutrition.

    Science.gov (United States)

    Wernerman, Jan

    2012-03-01

    To review and discuss the evidence and arguments to combine enteral nutrition and parenteral nutrition in the ICU, in particular with reference to the Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients (EPaNIC) study. The EPaNIC study shows an advantage in terms of discharges alive from the ICU when parenteral nutrition is delayed to day 8 as compared with combining enteral nutrition and parenteral nutrition from day 3 of ICU stay. The difference between the guidelines from the European Society of Enteral and Parenteral Nutrition in Europe and American Society for Parenteral and Enteral Nutrition/Society of Critical Care Medicine in North America concerning the combination of enteral nutrition and parenteral nutrition during the initial week of ICU stay was reviewed. The EPaNIC study clearly demonstrates that early parenteral nutrition in the ICU is not in the best interests of most patients. Exactly at what time point the combination of enteral nutrition and parenteral nutrition should be considered is still an open question.

  12. Rozwój morfologiczny i sprawności specjalnej 13 – letnich chłopców trenujących piłkę nożną w Klubie Sportowym „Pogoń” Łobżenica = Morphological and a special efficiency development 13-years old boys soccer summer training in a sports club "Chase" Łobżenica

    Directory of Open Access Journals (Sweden)

    Mariusz Klimczyk

    2016-07-01

      Słowa kluczowe: test, sprawność fizyczna, sprawność specjalna, piłka nożna, rozwój morfologiczny.   Abstract The aim of the work was to identify the morphological development and efficiency of a special 13-years old boys soccer summer training in "Chasing" Łobżenica. The test group consisted of 17 players who attended training classes three times a week (training unit was 60 minutes. In addition, participated four times a week in physical education classes in school. The study took place in two periods: the first in August 2015, and the second in April 2016. Measured weight and height of the body and was carried out "technical performance for boys aged 10-14 years old," George Talaga. There was progress and large diversity of subjects. Correlation between morphological features, and obtained points in the test performance special was released to moderate the relationship between these characteristics. The work shows that when the young player does not attend regularly for training, no progression of their skills. It is therefore necessary to systematic monitoring by the skill level of students, and applying adjustments in the training plan to in the future make it easier to eliminate this phenomenon. Keywords: test, physical fitness, the efficiency of the special, football, morphological development.

  13. Airbreathing combined cycle engine systems

    Science.gov (United States)

    Rohde, John

    1992-01-01

    The Air Force and NASA share a common interest in developing advanced propulsion systems for commercial and military aerospace vehicles which require efficient acceleration and cruise operation in the Mach 4 to 6 flight regime. The principle engine of interest is the turboramjet; however, other combined cycles such as the turboscramjet, air turborocket, supercharged ejector ramjet, ejector ramjet, and air liquefaction based propulsion are also of interest. Over the past months careful planning and program implementation have resulted in a number of development efforts that will lead to a broad technology base for those combined cycle propulsion systems. Individual development programs are underway in thermal management, controls materials, endothermic hydrocarbon fuels, air intake systems, nozzle exhaust systems, gas turbines and ramjet ramburners.

  14. Combined Surgical Treatment of Gynecomastia

    Directory of Open Access Journals (Sweden)

    Yordanov Y.

    2015-05-01

    Full Text Available Surgical treatment of gynecomastia could present unique challenges for the plastic surgeon. Achieving a good balance between effectiveness of the selected approach and the satisfactory aesthetic outcome often is a difficult endeavor. Optimal surgical treatment involves a combination of liposuction and direct excision. In the present study the charts of 11 patients treated with suction-assisted liposuction and direct surgical excision were retrospectively reviewed; a special emphasis is placed on the surgical technique. The mean follow-up period of the patients was 11.6 months. No infection, hematoma, nipple-areola complex necrosis and nipple retraction was encountered in this series. The combined surgical treatment of gynecomastia has shown to be a reliable technique in both small and moderate breast enlargement including those with skin excess.

  15. Chemical and natural stressors combined:

    DEFF Research Database (Denmark)

    Gergs, André; Zenker, Armin; Grimm, Volker

    2013-01-01

    In addition to natural stressors, populations are increasingly exposed to chemical pollutants released into the environment. We experimentally demonstrate the loss of resilience for Daphnia magna populations that are exposed to a combination of natural and chemical stressors even though effects...... demonstrates that population size can be a poor endpoint for risk assessments of chemicals and that ignoring disturbance interactions can lead to severe underestimation of extinction risk...

  16. Combination chemoprevention with grape antioxidants.

    Science.gov (United States)

    Singh, Chandra K; Siddiqui, Imtiaz A; El-Abd, Sabah; Mukhtar, Hasan; Ahmad, Nihal

    2016-06-01

    Antioxidant ingredients present in grape have been extensively investigated for their cancer chemopreventive effects. However, much of the work has been done on individual ingredients, especially focusing on resveratrol and quercetin. Phytochemically, whole grape represents a combination of numerous phytonutrients. Limited research has been done on the possible synergistic/additive/antagonistic interactions among the grape constituents. Among these phytochemical constituents of grapes, resveratrol, quercetin, kaempferol, catechin, epicatechin, and anthocyanins (cyanidin and malvidin) constitute more than 70% of the grape polyphenols. Therefore, these have been relatively well studied for their chemopreventive effects against a variety of cancers. While a wealth of information is available individually on cancer chemopreventive/anti-proliferative effects of resveratrol and quercetin, limited information is available regarding the other major constituents of grape. Studies have also suggested that multiple grape antioxidants, when used in combination, alone or with other agents/drugs show synergistic or additive anti-proliferative response. Based on strong rationale emanating from published studies, it seems probable that a combination of multiple grape ingredients alone or together with other agents could impart 'additive synergism' against cancer. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Imagining a Stata / Python Combination

    Science.gov (United States)

    Fiedler, James

    2012-01-01

    There are occasions when a task is difficult in Stata, but fairly easy in a more general programming language. Python is a popular language for a range of uses. It is easy to use, has many high ]quality packages, and programs can be written relatively quickly. Is there any advantage in combining Stata and Python within a single interface? Stata already offers support for user-written programs, which allow extensive control over calculations, but somewhat less control over graphics. Also, except for specifying output, the user has minimal programmatic control over the user interface. Python can be used in a way that allows more control over the interface and graphics, and in so doing provide a roundabout method for satisfying some user requests (e.g., transparency levels in graphics and the ability to clear the results window). My talk will explore these ideas, present a possible method for combining Stata and Python, and give examples to demonstrate how this combination might be useful.

  18. Combinations of complex dynamical systems

    CERN Document Server

    Pilgrim, Kevin M

    2003-01-01

    This work is a research-level monograph whose goal is to develop a general combination, decomposition, and structure theory for branched coverings of the two-sphere to itself, regarded as the combinatorial and topological objects which arise in the classification of certain holomorphic dynamical systems on the Riemann sphere. It is intended for researchers interested in the classification of those complex one-dimensional dynamical systems which are in some loose sense tame. The program is motivated by the dictionary between the theories of iterated rational maps and Kleinian groups.

  19. Combining Alphas via Bounded Regression

    Directory of Open Access Journals (Sweden)

    Zura Kakushadze

    2015-11-01

    Full Text Available We give an explicit algorithm and source code for combining alpha streams via bounded regression. In practical applications, typically, there is insufficient history to compute a sample covariance matrix (SCM for a large number of alphas. To compute alpha allocation weights, one then resorts to (weighted regression over SCM principal components. Regression often produces alpha weights with insufficient diversification and/or skewed distribution against, e.g., turnover. This can be rectified by imposing bounds on alpha weights within the regression procedure. Bounded regression can also be applied to stock and other asset portfolio construction. We discuss illustrative examples.

  20. Radiation, chemicals and combined effects

    International Nuclear Information System (INIS)

    Sinclair, W.K.

    1991-01-01

    A brief background has been provided on current carcinogenic risks from ionizing radiation and their magnitude in background circumstances. The magnitude of the risks from possibly carcinogenic chemicals at background levels in air, water and food are surprisingly similar. The exception is, perhaps, for the single source of radon which, while variable, on the average stands out above all other sources. Some basic principles concerning the interaction of combined radiation and chemicals and some practical examples where the two interact synergistically to enhance radiation effects has also been provided. Areas for human research in the future are discussed. (Author)

  1. [Combination chemotherapy of experimental leukemia].

    Science.gov (United States)

    Emanuel', N M; Konovalova, N P; D'iachkovskaia, R F

    1977-01-01

    In the present work an attempt was made to gain greater therapeutic effect of diazane coupled with adriamycin and sarcolysin. Leucemias L-1210 and La served as a model. In leucosis La diazane was injected once in 5 days. Either an additional injection of adriamycin two days prior to diazane injection or sarcolysin injected simultaneously with diazane enabled the authors to obtain a distinct synergestic effect. In leucemia L-1210 a simultaneous administration of diazane and sarcolysin also contributes to considerably longer survival of leucemic animals. Such combinations are likely to be promising in their clinical use.

  2. Malignant peritoneal pseudomyxona: Combined treatment

    International Nuclear Information System (INIS)

    Martin, A.; Alvarado, E.; Marcos, A.; Palacios, E.; Gomez, A.

    1993-01-01

    We describe a special treatment for the malignant peritoneal pseudomyxoma as suggested by Sugarbaker. Shortly, it is a combination of surgical cytoreduction with a curative aim, completed with inmediate postoperative intraperitoneal chemotherapy. Having in mind the lack of metastasic danger of these tumours, as well as its lack of infiltrative character, by this surgical technique which consists in five different ''peritonectomies'', one may be able to free the patient of macroscopic tumour. The additional intraperitoneal chemotherapy might contribute to increase the survival of these patients and, perhaps, even to cure them. (Author) 12 refs

  3. Strategies for combinational cancer therapies

    International Nuclear Information System (INIS)

    Khleif, Samir

    2014-01-01

    The countless pre-clinical studies and many clinical trials that have applied tumor antigen-based therapies for the cancer treatment, and although the necessary tumor-specific immune response may be elicited in tumor-bearing hosts, this was not sufficient for the positive therapeutic outcome since there are multiple mechanisms that tumors develop to escape immune surveillance. The tumor-mediated inhibitory mechanisms involve co-inhibitory receptor-ligand interactions, such as PD-1/ PD-L1, secretion of inhibitory molecules, such as TGFb, and recruitment of suppressive cells, such as regulatory T cells (Treg), myeloid derived suppressor cells (MDSC), etc. Therefore, we hypothesized that successful cancer immunotherapy requires not only induction and enhancement of effector immune response but also simultaneous targeting of suppressor arm of immune system, thus in addition to enhancing antigen-specific immunity using vaccines or radiation therapy, one should also target tumor-mediated immune suppression to improve the overall efficacy of therapy. We developed multiple strategies to target various tumor-mediated immune inhibitory mechanisms that can enhance anti-tumor immunity and restructure tumor microenvironment to allow effector cells generated due to vaccination or radiation therapy to function potently. We evaluated the immune and therapeutic efficacy of multiple combinational therapies, including blocking and agonist antibodies to co-inhibitory/co-stimulatory molecules, such as PD-1, PD-L1, OX40, CTLA-4, GITR, inhibitors and neutralizing antibodies to inhibitory cytokines/molecules, such as IL-10, TGFb, IDO, and small molecules for selective inhibition of Tregs. In addition to evaluation of anti-tumor efficacy we are also investigated cellular and molecular mechanisms of action for these agents when combined with vaccine or radiation therapy and exploring the interactions between compounds within combinational therapies in animal tumor models. We are

  4. Radiation tolerant combinational logic cell

    Science.gov (United States)

    Maki, Gary R. (Inventor); Gambles, Jody W. (Inventor); Whitaker, Sterling (Inventor)

    2009-01-01

    A system has a reduced sensitivity to Single Event Upset and/or Single Event Transient(s) compared to traditional logic devices. In a particular embodiment, the system includes an input, a logic block, a bias stage, a state machine, and an output. The logic block is coupled to the input. The logic block is for implementing a logic function, receiving a data set via the input, and generating a result f by applying the data set to the logic function. The bias stage is coupled to the logic block. The bias stage is for receiving the result from the logic block and presenting it to the state machine. The state machine is coupled to the bias stage. The state machine is for receiving, via the bias stage, the result generated by the logic block. The state machine is configured to retain a state value for the system. The state value is typically based on the result generated by the logic block. The output is coupled to the state machine. The output is for providing the value stored by the state machine. Some embodiments of the invention produce dual rail outputs Q and Q'. The logic block typically contains combinational logic and is similar, in size and transistor configuration, to a conventional CMOS combinational logic design. However, only a very small portion of the circuits of these embodiments, is sensitive to Single Event Upset and/or Single Event Transients.

  5. [Familial combined hyperlipidemia: consensus document].

    Science.gov (United States)

    Mata, Pedro; Alonso, Rodrigo; Ruíz-Garcia, Antonio; Díaz-Díaz, Jose L; González, Noemí; Gijón-Conde, Teresa; Martínez-Faedo, Ceferino; Morón, Ignacio; Arranz, Ezequiel; Aguado, Rocío; Argueso, Rosa; Perez de Isla, Leopoldo

    2014-10-01

    Familial combined hyperlipidemia (FCH) is a frequent disorder associated with premature coronary artery disease. It is transmitted in an autosomal dominant manner, although there is not a unique gene involved. The diagnosis is performed using clinical criteria, and variability in lipid phenotype and family history of hyperlipidemia are necessaries. Frequently, the disorder is associated with type2 diabetes mellitus, arterial hypertension and central obesity. Patients with FCH are considered as high cardiovascular risk and the lipid target is an LDL-cholesterol <100mg/dL, and <70mg/dL if cardiovascular disease or type 2 diabetes are present. Patients with FCH require lipid lowering treatment using potent statins and sometimes, combined lipid-lowering treatment. Identification and management of other cardiovascular risk factors as type 2 diabetes and hypertension are fundamental to reduce cardiovascular disease burden. This document gives recommendations for the diagnosis and global treatment of patients with FCH directed to specialists and general practitioners. Copyright © 2014 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España. All rights reserved.

  6. Combined trauma in peaceful time

    Directory of Open Access Journals (Sweden)

    Chaika V.A.

    2014-06-01

    Full Text Available In the article epidemiological features of combined trauma (CT, characteristic for the industrial region were summarized. 486 cases of CT were analyzed for the period from 2010 to 2012. Male patients dominated. 267 (54.9% patients were the age from 25 to 44 years. Most often the damage occurred in 2 anatomic regions (AR - 224 (46.1%, 3 AR - 177 (36.4% and 4 or more - 85 (17.5%. Trau¬matic brain injury - 94.2%, skeletal trauma - 70.6%, the trauma of the chest and abdomen - 68.4% and 35.7%, respectively prevailed. Injury of the abdominal cavity as a dominant one - 148 (30.5% occupied the first place. In 17 (3.5% cases it was impossible to establish the dominant damage. Mortality rate was directly dependent on the type of the trauma and patient's age. Maximum values were found in the combined brain injury and that of abdominal organs - 28.6%, as well as in the group of patients older than 60 years - 35.1%. From 2010 to 2012 the overall mortality decreased by 3.5%.

  7. Combining Renewable Energy With Coal

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-09-01

    There are various possibilities for incorporating biomass into coal-fuelled processes and a number of these are already being deployed commercially. Others are the focus of ongoing research and development. Biomass materials can vary widely, although the present report concentrates mainly on the use of woody biomass in the form of forest residues. Potentially, large amounts are available in some parts of the world. However, not all forested regions are very productive, and the degree of commercial exploitation varies considerably between individual countries. The level of wastage associated with timber production and associated downstream processing is frequently high and considerable quantities of potentially useful materials are often discarded. Overall, forest residues are a largely underexploited resource. Combining the use of biomass with coal can be beneficial, particularly from an environmental standpoint, although any such process may have its limitations or drawbacks. Each coal type and biomass feedstock has different characteristics although by combining the two, it may be possible to capitalise on the advantages of each, and minimise their individual disadvantages. An effective way is via cogasification, and useful operating experience has been achieved in a number of large-scale coal-fuelled gasification and IGCC plants. Cogasification can be the starting point for producing a range of products that include synthetic natural gas, chemicals, fertilisers and liquid transport fuels. It also has the potential to form the basis of systems that combine coal and biomass use with other renewable energy technologies to create clean, efficient energy-production systems. Thus, various hybrid energy concepts, some based on coal/biomass cogasification, have been proposed or are in the process of being developed or trialled. Some propose to add yet another element of renewable energy to the system, generally by incorporating electricity generated by intermittent

  8. Combined Shape and Topology Optimization

    DEFF Research Database (Denmark)

    Christiansen, Asger Nyman

    Shape and topology optimization seeks to compute the optimal shape and topology of a structure such that one or more properties, for example stiffness, balance or volume, are improved. The goal of the thesis is to develop a method for shape and topology optimization which uses the Deformable...... Simplicial Complex (DSC) method. Consequently, we present a novel method which combines current shape and topology optimization methods. This method represents the surface of the structure explicitly and discretizes the structure into non-overlapping elements, i.e. a simplicial complex. An explicit surface...... representation usually limits the optimization to minor shape changes. However, the DSC method uses a single explicit representation and still allows for large shape and topology changes. It does so by constantly applying a set of mesh operations during deformations of the structure. Using an explicit instead...

  9. How rats combine temporal cues.

    Science.gov (United States)

    Guilhardi, Paulo; Keen, Richard; MacInnis, Mika L M; Church, Russell M

    2005-05-31

    The procedures for classical and operant conditioning, and for many timing procedures, involve the delivery of reinforcers that may be related to the time of previous reinforcers and responses, and to the time of onsets and terminations of stimuli. The behavior resulting from such procedures can be described as bouts of responding that occur in some pattern at some rate. A packet theory of timing and conditioning is described that accounts for such behavior under a wide range of procedures. Applications include the food searching by rats in Skinner boxes under conditions of fixed and random reinforcement, brief and sustained stimuli, and several response-food contingencies. The approach is used to describe how multiple cues from reinforcers and stimuli combine to determine the rate and pattern of response bouts.

  10. Factorized combinations of Virasoro characters

    International Nuclear Information System (INIS)

    Bytsko, A.G.; Fring, A.

    2000-01-01

    We investigate linear combinations of characters for minimal Virasoro models which are representable as a product of several basic blocks. Our analysis is based on consideration of asymptotic behaviour of the characters in the quasi-classical limit. In particular, we introduce a notion of the secondary effective central charge. We find all possible cases for which factorization occurs on the base of the Gauss-Jacobi or the Watson identities. Exploiting these results, we establish various types of identities between different characters. In particular, we present several identities generalizing the Rogers-Ramanujan identities. Applications to quasi-particle representations, modular invariant partition functions, super-conformal theories and conformal models with boundaries are briefly discussed. (orig.)

  11. Combining Narrative and Numerical Simulation

    DEFF Research Database (Denmark)

    Hansen, Mette Sanne; Ladeby, Klaes Rohde; Rasmussen, Lauge Baungaard

    2011-01-01

    for decision makers to systematically test several different outputs of possible solutions in order to prepare for future consequences. The CSA can be a way to evaluate risks and address possible unforeseen problems in a more methodical way than either guessing or forecasting. This paper contributes...... to the decision making in operations and production management by providing new insights into modelling and simulation based on the combined narrative and numerical simulation approach as a tool for strategy making. The research question asks, “How can the CSA be applied in a practical context to support strategy...... making?” The paper uses a case study where interviews and observations were carried out in a Danish corporation. The CSA is a new way to address decision making and has both practical value and further expands the use of strategic simulation as a management tool....

  12. Severe combined immune deficiency syndrome

    International Nuclear Information System (INIS)

    Saleem, A.F.; Khawaja, R.D.A.; Shaikh, A.S.; Ali, S.A.; Zaidi, A.K.M.

    2013-01-01

    To determine the clinico-demographic features and laboratory parameters of children with severe combined immunodeficiency (SCID). Study Design: Case series. Place and Duration of Study: Department of Paediatrics and Child Health, the Aga Khan University, Karachi, from July 2006 to July 2011. Methodology: Thirteen infants who were discharged with a diagnosis of SCID were inducted in the study. Their clinicodemographic features and laboratory parameters were determined. Descriptive statistics has been used for computing frequency and percentage. Results: The median age at diagnosis was five months; 5 infants presented within 3 months of life. Three-fourth (77%) were males. Most of the infants were severely malnourished (85%) at the time of presentation. More than two-thirds (69%) were products of consanguineous marriages. All subjects had severe lymphopenia (absolute lymphocyte count (ALC) ranging between 170 – 2280) and low T and B lymphocyte counts. Conclusion: SCID should be considered in infants presenting with severe and recurrent infections. Low ALC (< 2500/mm3), is a reliable diagnostic feature of SCID. These infants should be promptly referred to a facility where stem cell transplant can be done. (author)

  13. Efficient Web Services Policy Combination

    Science.gov (United States)

    Vatan, Farrokh; Harman, Joseph G.

    2010-01-01

    Large-scale Web security systems usually involve cooperation between domains with non-identical policies. The network management and Web communication software used by the different organizations presents a stumbling block. Many of the tools used by the various divisions do not have the ability to communicate network management data with each other. At best, this means that manual human intervention into the communication protocols used at various network routers and endpoints is required. Developing practical, sound, and automated ways to compose policies to bridge these differences is a long-standing problem. One of the key subtleties is the need to deal with inconsistencies and defaults where one organization proposes a rule on a particular feature, and another has a different rule or expresses no rule. A general approach is to assign priorities to rules and observe the rules with the highest priorities when there are conflicts. The present methods have inherent inefficiency, which heavily restrict their practical applications. A new, efficient algorithm combines policies utilized for Web services. The method is based on an algorithm that allows an automatic and scalable composition of security policies between multiple organizations. It is based on defeasible policy composition, a promising approach for finding conflicts and resolving priorities between rules. In the general case, policy negotiation is an intractable problem. A promising method, suggested in the literature, is when policies are represented in defeasible logic, and composition is based on rules for non-monotonic inference. In this system, policy writers construct metapolicies describing both the policy that they wish to enforce and annotations describing their composition preferences. These annotations can indicate whether certain policy assertions are required by the policy writer or, if not, under what circumstances the policy writer is willing to compromise and allow other assertions to take

  14. Combined modalities: chemotherapy/radiotherapy. Meeting summary

    International Nuclear Information System (INIS)

    Phillips, T.L.

    1979-01-01

    The effects of combined modalities, the standardization of terminology, the mechanisms of chemotherapeutic interactions with radiation and responses of normal and tumor systems are summarized from information presented at the Conference on Combined Modalities

  15. 27 CFR 6.93 - Combination packaging.

    Science.gov (United States)

    2010-04-01

    ..., DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.93 Combination packaging. The act by an industry member of packaging and distributing distilled spirits, wine, or malt beverages in combination...

  16. Combining multiple classifiers for age classification

    CSIR Research Space (South Africa)

    Van Heerden, C

    2009-11-01

    Full Text Available The authors compare several different classifier combination methods on a single task, namely speaker age classification. This task is well suited to combination strategies, since significantly different feature classes are employed. Support vector...

  17. Systemic combination treatment for psoriasis: a review

    DEFF Research Database (Denmark)

    Jensen, Peter; Skov, Lone; Zachariae, Claus

    2010-01-01

    exist for the use of systemic combination therapy. Therefore, our aim was to review the current literature on systemic anti-psoriatic combination regimens. We searched PubMed and identified 98 papers describing 116 studies (23 randomized) reporting on the effect of various systemic combination...

  18. Binocular Combination of Second-Order Stimuli

    Science.gov (United States)

    Zhou, Jiawei; Liu, Rong; Zhou, Yifeng; Hess, Robert F.

    2014-01-01

    Phase information is a fundamental aspect of visual stimuli. However, the nature of the binocular combination of stimuli defined by modulations in contrast, so-called second-order stimuli, is presently not clear. To address this issue, we measured binocular combination for first- (luminance modulated) and second-order (contrast modulated) stimuli using a binocular phase combination paradigm in seven normal adults. We found that the binocular perceived phase of second-order gratings depends on the interocular signal ratio as has been previously shown for their first order counterparts; the interocular signal ratios when the two eyes were balanced was close to 1 in both first- and second-order phase combinations. However, second-order combination is more linear than previously found for first-order combination. Furthermore, binocular combination of second-order stimuli was similar regardless of whether the carriers in the two eyes were correlated, anti-correlated, or uncorrelated. This suggests that, in normal adults, the binocular phase combination of second-order stimuli occurs after the monocular extracting of the second-order modulations. The sensory balance associated with this second-order combination can be obtained from binocular phase combination measurements. PMID:24404180

  19. Combined eye-atmosphere visibility model

    Science.gov (United States)

    Kaufman, Y. J.

    1981-01-01

    Existing models of the optical characteristics of the eye are combined with a recent model of optical characteristics of the atmosphere given by its modulation transfer function. This combination results in the combined eye-atmosphere performance given by the product of their modulation transfer functions. An application for the calculation of visibility thresholds in the case of a two-halves field is given.

  20. GLONASS orbit/clock combination in VNIIFTRI

    Science.gov (United States)

    Bezmenov, I.; Pasynok, S.

    2015-08-01

    An algorithm and a program for GLONASS satellites orbit/clock combination based on daily precise orbits submitted by several Analytic Centers were developed. Some theoretical estimates for combine orbit positions RMS were derived. It was shown that under condition that RMS of satellite orbits provided by the Analytic Centers during a long time interval are commensurable the RMS of combine orbit positions is no greater than RMS of other satellite positions estimated by any of the Analytic Centers.

  1. Systemic combination treatment for psoriasis: a review

    DEFF Research Database (Denmark)

    Jensen, Peter; Skov, Lone; Zachariae, Claus

    2010-01-01

    Psoriasis is a chronic inflammatory skin disease, which affects approximately 2.6% of the population in Northern Europe and Scandinavia. In order to achieve disease control, combinations of systemic treatments are sometimes needed for variable time periods. However, no evidence-based guidelines...... exist for the use of systemic combination therapy. Therefore, our aim was to review the current literature on systemic anti-psoriatic combination regimens. We searched PubMed and identified 98 papers describing 116 studies (23 randomized) reporting on the effect of various systemic combination...

  2. Radiation and combined heat transfer in channels

    International Nuclear Information System (INIS)

    Tamonis, M.

    1986-01-01

    This book presents numerical methods of calculation of radiative and combined heat transfer in channel flows of radiating as well as nonradiating media. Results obtained in calculations for flow conditions of combustion products from organic fuel products are given and methods used in determining the spectral optical properties of molecular gases are analyzed. The book presents applications of heat transfer in solving problems. Topic covered are as follows: optical properties of molecular gases; transfer equations for combined heat transfer; experimental technique; convective heat transfer in heated gas flows; radiative heat transfer in gaseous media; combined heat transfer; and radiative and combined heat transfer in applied problems

  3. 12 CFR 5.33 - Business combinations.

    Science.gov (United States)

    2010-01-01

    ... with safe and sound banking practices. (iii) Money laundering. The OCC considers the effectiveness of any insured depository institution involved in the business combination in combating money laundering...

  4. Combined strategies for the improvement of heterologous ...

    African Journals Online (AJOL)

    use

    2011-12-14

    Dec 14, 2011 ... Full Length Research Paper. Combined ... Three different cultivation strategies had been compared for the production of .... biorector using combined fermentation strategies, and the ... shaking flask was chosen as a host for the transformation of SalI- linearized ... sterile filtered after bioreactor sterilization.

  5. 7 CFR 51.304 - Combination grades.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946... Standards for Grades of Apples Grades § 51.304 Combination grades. (a) Combinations of the above grades may...

  6. IPTV program recommendation based on combination strategies

    Directory of Open Access Journals (Sweden)

    Li Hao

    2018-01-01

    Full Text Available As a new interactive service technology, IPTV has been extensively studying in the field of TV pro-gram recommendation, but the sparse of the user-program rating matrix and the cold-start problem is a bottleneck that the program recommended accurately. In this paper, a flexible combination of two recommendation strategies proposed, which explored the sparse and cold-start problem as well as the issue of user interest change over time. This paper achieved content-based filtering section and collaborative filtering section according to the two combination strategies, which effectively solved the cold-start program and over the sparse problem and the problem of users interest change over time. The experimental results showed that this combinational recommendation system in optimal parameters compared by using any one of two combination strategies or not using any combination strategy at all, and the reducing range of MAE is [2.7%,3%].The increasing range of precision and recall is [13.8%95.5%] and [0,97.8%], respectively. The experiment showed better results when using combinational recommendation system in optimal parameters than using each combination strategies individually or not using any combination strategy.

  7. A linear combination of modified Bessel functions

    Science.gov (United States)

    Shitzer, A.; Chato, J. C.

    1971-01-01

    A linear combination of modified Bessel functions is defined, discussed briefly, and tabulated. This combination was found to recur in the analysis of various heat transfer problems and in the analysis of the thermal behavior of living tissue when modeled by cylindrical shells.

  8. Using sentence combining in technical writing classes

    Science.gov (United States)

    Rosner, M.; Paul, T.

    1981-01-01

    Sentence combining exercises are advanced as a way to teach technical writing style without reliance upon abstractions, from which students do not learn. Such exercises: (1) give students regular writing practice; (2) teach the logic of sentence structure, sentence editing, and punctuation; (3) paragraph development and organization; and (4) rhetorical stance. Typical sentence, paragraph, and discourse level sentence combining exercises are described.

  9. 7 CFR 29.1008 - Combination symbols.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Combination symbols. 29.1008 Section 29.1008..., 13, 14 and Foreign Type 92) § 29.1008 Combination symbols. A color or group symbol used with another symbol to form the third factor of a grademark to denote a particular side or characteristic of the...

  10. COMBINED-SEWER OVERFLOW CONTROL AND TREATMENT

    Science.gov (United States)

    Combined-sewer overflow (CSO), along with sanitary-sewer overflow and stormwater are significant contributors of contamination to surface waters. During a rain event, the flow in a combined sewer system may exceed the capacity of the intercepting sewer leading to the wastewater t...

  11. Combine material against electromagnetic pulse disturbance

    International Nuclear Information System (INIS)

    Liu Yan

    2004-01-01

    A novel combined material is introduced, which is hard against electromagnetic pulse disturbance, The attenuation characteristics and the penetration probability of the combine material is discussed in detail. The penetration probability of electromagnetic wave is calculated approximately and the characteristic curve is measured for this material. (authors)

  12. Economic and Accounting Issues Regarding Business Combination

    OpenAIRE

    Asalos Nicoleta; Georgescu Cristina Elena

    2011-01-01

    Some businesses units do not survives the competition and finally close the business. Hence the excessive competition became a very powerful cause of business combination. Elimination of competition means creating monopoly in the market. Adopting IFRS 3 was to improve the relevance, reliability and comparability of the information that a reporting entity provides in its financial statements about a business combination and its effects.

  13. On combining algorithms for deformable image registration

    NARCIS (Netherlands)

    Muenzing, S.E.A.; Ginneken, van B.; Pluim, J.P.W.; Dawant, B.M.

    2012-01-01

    We propose a meta-algorithm for registration improvement by combining deformable image registrations (MetaReg). It is inspired by a well-established method from machine learning, the combination of classifiers. MetaReg consists of two main components: (1) A strategy for composing an improved

  14. Multimedia: How to Combine Language and Visuals

    Directory of Open Access Journals (Sweden)

    Holger Horz

    2008-08-01

    Full Text Available In the last decade, advanced computer technology has allowed for development of information systems and learning environments that combine language with other forms of human communication in innovative ways. Language in the form of written texts, for example, can be combined not only with static pictures or graphs as in printed material, but also with animation or video.

  15. Investigations on combined injuries. Pt. 24

    International Nuclear Information System (INIS)

    Sedlmeier, H.; Lehner, K.; Werdan, K.; Messerschmidt, O.

    1979-01-01

    Combined injuries were inflicted upon NMRI-mice, hurting each with an open skin wound subsequent to sublethal exposition to X-rays. Lethality among animals with combined injuries was between 40 and 60%, while animals only irradiated and those with only a skin wound had lethalities between 10 and 20% and 0%, respectively. Blood circulation and respiration of animals injured with combined lesions were studied in an attempt to understand the cause of the high lethality in this group. The blood volume and the oxygen transport capacity were drastically reduced in animals with combined injuries as compared to those in animals only irradiated, although plasma volume, vascular permeability and distribution of the blood volume remained similar in both groups. Analyses of gases and acid/base composition of blood revealed neither respiratory nor metabolic acidosis. These findings indicate that combined injuries hardly impair blood circulation and respiratory function. (orig.) [de

  16. Data combinations accounting for LISA spacecraft motion

    International Nuclear Information System (INIS)

    Shaddock, Daniel A.; Tinto, Massimo; Estabrook, Frank B.; Armstrong, J.W.

    2003-01-01

    The laser interferometer space antenna is an array of three spacecraft in an approximately equilateral triangle configuration which will be used as a low-frequency gravitational wave detector. We present here new generalizations of the Michelson- and Sagnac-type time-delay interferometry data combinations. These combinations cancel laser phase noise in the presence of different up and down propagation delays in each arm of the array, and slowly varying systematic motion of the spacecraft. The gravitational wave sensitivities of these generalized combinations are the same as previously computed for the stationary cases, although the combinations are now more complicated. We introduce a diagrammatic representation to illustrate that these combinations are actually synthesized equal-arm interferometers

  17. Combination of the LEP II ffbar Results

    CERN Document Server

    Geweniger, C; Elsing, M; Goy, C; Holt, J; Liebig, W; Minard, M N; Renton, P B; Riemann, S; Sachs, K; Ward, P; Wynhoff, S

    2002-01-01

    Preliminary combinations of measurements of the 4 LEP collaborations of the process e+e-->ffbar at LEP-II are presented, using data from the full LEP-II data set where available. Cross-sections and forward-backward asymmetry measurements are combined for the full LEP-II data set. Combined differential cross-sections $\\frac{{\\rm d}\\sigma}{{\\rm d}\\cos\\theta}$ for electron-pairs, muon pair and tau-pair final states are presented. Measurements of the production of heavy flavours are combined. The combined results are interpreted in terms of contact interactions and the exchange Z' bosons and leptoquarks, and within models of low scale gravity in large extra dimensions.

  18. Combining Ideas in Crowdsourced Idea Generation

    Directory of Open Access Journals (Sweden)

    Wang Kai

    2017-02-01

    Full Text Available Collecting ideas through crowdsourcing has become a common practice for companies to benefit from external ideas and innovate. It is desirable that crowd members build on each other's ideas to achieve synergy. This study proposes and verifies a new method for idea combination which can result in combined ideas that are both novel and useful. The domain-specific knowledge of crowd members does not influence the effectiveness of such idea combination. The new method can be used for collecting highly creative ideas from the crowd. The implications for future research are discussed.

  19. Combined algorithms in nonlinear problems of magnetostatics

    International Nuclear Information System (INIS)

    Gregus, M.; Khoromskij, B.N.; Mazurkevich, G.E.; Zhidkov, E.P.

    1988-01-01

    To solve boundary problems of magnetostatics in unbounded two- and three-dimensional regions, we construct combined algorithms based on a combination of the method of boundary integral equations with the grid methods. We study the question of substantiation of the combined method of nonlinear magnetostatic problem without the preliminary discretization of equations and give some results on the convergence of iterative processes that arise in non-linear cases. We also discuss economical iterative processes and algorithms that solve boundary integral equations on certain surfaces. Finally, examples of numerical solutions of magnetostatic problems that arose when modelling the fields of electrophysical installations are given too. 14 refs.; 2 figs.; 1 tab

  20. Studies of a Combined-Cycle Engine

    OpenAIRE

    苅田, 丈士; KANDA, Takeshi

    2003-01-01

    For a Single-Stage-to-Orbit (SSTO) aerospace plane (Fig.1), several engines will be necessary to reach orbit. The combined-cycle engine incorporates several operational modes in a single engine. Study of the combined cycle engine has a long history, and several kinds of such engines have been proposed and studied. When several engines are mounted on a vehicle, each engine of the system will show a performance higher than that of the combined cycle engine. However, during the operation of one ...

  1. Combination solar photovoltaic heat engine energy converter

    Science.gov (United States)

    Chubb, Donald L.

    1987-01-01

    A combination solar photovoltaic heat engine converter is proposed. Such a system is suitable for either terrestrial or space power applications. The combination system has a higher efficiency than either the photovoltaic array or the heat engine alone can attain. Advantages in concentrator and radiator area and receiver mass of the photovoltaic heat engine system over a heat-engine-only system are estimated. A mass and area comparison between the proposed space station organic Rankine power system and a combination PV-heat engine system is made. The critical problem for the proposed converter is the necessity for high temperature photovoltaic array operation. Estimates of the required photovoltaic temperature are presented.

  2. Memristive Perceptron for Combinational Logic Classification

    Directory of Open Access Journals (Sweden)

    Lidan Wang

    2013-01-01

    Full Text Available The resistance of the memristor depends upon the past history of the input current or voltage; so it can function as synapse in neural networks. In this paper, a novel perceptron combined with the memristor is proposed to implement the combinational logic classification. The relationship between the memristive conductance change and the synapse weight update is deduced, and the memristive perceptron model and its synaptic weight update rule are explored. The feasibility of the novel memristive perceptron for implementing the combinational logic classification (NAND, NOR, XOR, and NXOR is confirmed by MATLAB simulation.

  3. Combined Sparsifying Transforms for Compressive Image Fusion

    Directory of Open Access Journals (Sweden)

    ZHAO, L.

    2013-11-01

    Full Text Available In this paper, we present a new compressive image fusion method based on combined sparsifying transforms. First, the framework of compressive image fusion is introduced briefly. Then, combined sparsifying transforms are presented to enhance the sparsity of images. Finally, a reconstruction algorithm based on the nonlinear conjugate gradient is presented to get the fused image. The simulations demonstrate that by using the combined sparsifying transforms better results can be achieved in terms of both the subjective visual effect and the objective evaluation indexes than using only a single sparsifying transform for compressive image fusion.

  4. Cost Comparison of Conventional Gray Combined Sewer Overflow Control Infrastructure versus a Green/Gray Combination

    Science.gov (United States)

    This paper outlines a life-cycle cost analysis comparing a green (rain gardens) and gray (tunnels) infrastructure combination to a gray-only option to control combined sewer overflow in the Turkey Creek Combined Sewer Overflow Basin, in Kansas City, MO. The plan area of this Bas...

  5. Combining nonthermal technologies to control foodborne microorganisms.

    Science.gov (United States)

    Ross, Alexander I V; Griffiths, Mansel W; Mittal, Gauri S; Deeth, Hilton C

    2003-12-31

    Novel nonthermal processes, such as high hydrostatic pressure (HHP), pulsed electric fields (PEFs), ionizing radiation and ultrasonication, are able to inactivate microorganisms at ambient or sublethal temperatures. Many of these processes require very high treatment intensities, however, to achieve adequate microbial destruction in low-acid foods. Combining nonthermal processes with conventional preservation methods enhances their antimicrobial effect so that lower process intensities can be used. Combining two or more nonthermal processes can also enhance microbial inactivation and allow the use of lower individual treatment intensities. For conventional preservation treatments, optimal microbial control is achieved through the hurdle concept, with synergistic effects resulting from different components of the microbial cell being targeted simultaneously. The mechanisms of inactivation by nonthermal processes are still unclear; thus, the bases of synergistic combinations remain speculative. This paper reviews literature on the antimicrobial efficiencies of nonthermal processes combined with conventional and novel nonthermal technologies. Where possible, the proposed mechanisms of synergy is mentioned.

  6. Combined assessment (aspiration cytology and mammography) of ...

    African Journals Online (AJOL)

    Combined assessment (aspiration cytology and mammography) of clinically suspicious breast masses. W.F. van Wyk, D Dent, E Anne Hacking, Genevieve Learmonth, R.E. Kottler, C Anne Gudgeon, A Tiltman ...

  7. Advances in combination therapy of lung cancer

    DEFF Research Database (Denmark)

    Wu, Lan; Leng, Donglei; Cun, Dongmei

    2017-01-01

    Lung cancer is a complex disease caused by a multitude of genetic and environmental factors. The progression of lung cancer involves dynamic changes in the genome and a complex network of interactions between cancer cells with multiple, distinct cell types that form tumors. Combination therapy......, including small molecule drugs and biopharmaceuticals, which make the optimization of dosing and administration schedule challenging. This article reviews the recent advances in the design and development of combinations of pharmaceuticals for the treatment of lung cancer. Focus is primarily on rationales...... for the selection of specific combination therapies for lung cancer treatment, and state of the art of delivery technologies and dosage regimens for the combinations, tested in preclinical and clinical trials....

  8. Combining Teacher Assessment Scores with External Examination ...

    African Journals Online (AJOL)

    Combining Teacher Assessment Scores with External Examination Scores for Certification: Comparative Study of Four Statistical Models. ... University entrance examination scores in mathematics were obtained for a subsample of 115 ...

  9. Investigations on combined injuries. Pt. 25

    International Nuclear Information System (INIS)

    Lehner, K.; Werdan, K.; Sedlmeier, H.; Zimmer, P.; Messerschmidt, O.

    1979-01-01

    In NMRI-mice injured with combined lesions (whole-body irradiation with 500 R and, two or seven days later, an open skin wound), lethality increased from 10 to 20% following sole irradiation up to 60%. Investigations of urinary excretion and serum levels in animals with combined injuries did not show undue elevations of the levels of electrolytes, creatinine, urea, uric acid and acid or alkaline equivalents. Analysis of lactate, pyruvate, ATP and ADP in liver tissue and blood serum indicated no significant changes in the energy metabolism in animals with combined injuries in comparison with mice irradiated only. These findings and those of our last communication (24. Mitteilung) seem to be incompatible wit the presence of a shock state as cause of the high lethality of mice with combined injuries. (orig.) 891 MG/orig. 892 RKD [de

  10. Predictors of combined cognitive and physical decline

    NARCIS (Netherlands)

    Atkinson, H.H.; Cesari, M.; Kritchevsky, S.B.; Penninx, B.W.J.H.; Fried, L.P.; Guralnik, J.M.; Williamson, J.D.

    2005-01-01

    OBJECTIVES: To determine the incidence and correlates of combined declines in cognitive and physical performance. DESIGN: Cohort study of community-dwelling older women with moderate to severe disability. SETTING: The community surrounding Baltimore, Maryland. PARTICIPANTS: Participants in the

  11. Immunotherapy Combination Approved for Advanced Kidney Cancer

    Science.gov (United States)

    FDA has approved the combination of the immunotherapy drugs nivolumab (Opdivo) and ipilimumab (Yervoy) as an initial treatment for some patients with advanced kidney cancer. The approval is expected to immediately affect patient care, as this Cancer Currents post explains.

  12. Learning about Severe Combined Immunodeficiency (SCID)

    Science.gov (United States)

    ... immunodeficiency From The Journal of Allergy and Clinical Immunology Learning About Severe Combined Immunodeficiency (SCID) What is ... immunodeficiency From The Journal of Allergy and Clinical Immunology Get Email Updates Privacy Copyright Contact Accessibility Plug- ...

  13. Novel Combination Chemotherapy for Localized Ewing Sarcoma

    Science.gov (United States)

    In this clinical trial, researchers will test whether the addition of the drug combination vincristine, topotecan, and cyclophosphamide to a standard chemotherapy regimen improves overall survival in patients with extracranial Ewing

  14. Optimizing sales areas of combined transport chains

    Directory of Open Access Journals (Sweden)

    Philip Michalk

    2013-12-01

    Full Text Available Background: Combined transport chains (such as intermodal transport, have certain advantages. The main advantage from customer points of view is the possibility to bundle freight and thereby decrease transport costs. On the other hand, a combined transport chain can cause longer transport times, due to the necessary transshipment processes. Methods: The area around a terminal, in which a combined service has favourable properties to a customer in comparison to a direct transport, can be understood as a sales-area, in which a combined transport product is marketable. The aim of this paper was to find a method to determine the best shape and size of this area. Results and conclusions: The paper at hand lined out a method in order to calculate such a sales area and determine which geographical points around a terminal have an advantage in comparison to a direct transport service.

  15. Unrewarded Object Combinations in Captive Parrots

    Directory of Open Access Journals (Sweden)

    Alice Marie Isabel Auersperg

    2014-11-01

    Full Text Available In primates, complex object combinations during play are often regarded as precursors of functional behavior. Here we investigate combinatory behaviors during unrewarded object manipulation in seven parrot species, including kea, African grey parrots and Goffin cockatoos, three species previously used as model species for technical problem solving. We further examine a habitually tool using species, the black palm cockatoo. Moreover, we incorporate three neotropical species, the yellow- and the black-billed Amazon and the burrowing parakeet. Paralleling previous studies on primates and corvids, free object-object combinations and complex object-substrate combinations such as inserting objects into tubes/holes or stacking rings onto poles prevailed in the species previously linked to advanced physical cognition and tool use. In addition, free object-object combinations were intrinsically structured in Goffin cockatoos and in kea.

  16. COMBINED ALUMINIUM SULFATE/HYDROXIDE PROCESS FOR ...

    African Journals Online (AJOL)

    sulfate, and used for fluoride removal from water by combining with Nalgonda Technique. ... effects on human health and could result in fluorosis. ... [23], nanoscale aluminium oxide hydroxide (AlOOH) [24] and natural zeolite [25], were among.

  17. Pulse wave velocity in familial combined hyperlipidemia.

    NARCIS (Netherlands)

    Avest, E. ter; Holewijn, S.; Bredie, S.J.H.; Tits, L.J.H. van; Stalenhoef, A.F.H.; Graaf, J. de

    2007-01-01

    BACKGROUND: In the present cross-sectional study we investigated whether familial combined hyperlipidemia (FCH) is associated with an increased arterial wall stiffness, and whether measures of arterial wall stiffness in FCH family members could contribute to cardiovascular risk stratification.

  18. Methodology for combining dynamic responses. Technical report

    International Nuclear Information System (INIS)

    Mattu, R.K.

    1980-05-01

    Procedures in accordance with Appendix A of 10 CFR 50, GDC 2, call for an appropriate combination of the effects of the accident loads and loads caused by natural phenomena (such as earthquakes) to be reflected in the design bases of safety equipment. This requirement of interaction of loads has been implemented in various ways both within the NRC and the Nuclear Industry. An NRR Working Group constituted to examine load combination methodologies developed recommendations which were published in September 1978 as NUREG-0484, (PB-287 432). Revision 1 of NUREG-0484 extends the conclusions of the original NUREG-0484 on the use of SRSS methodology for the combination of SSE and LOCA responses beyond RCPB to any other ASME Section III, Class 1, 2, or 3 affected system, component or support, and provides criteria for the combination of dynamic responses other than SSE and LOCA

  19. Coherent combining pulse bursts in time domain

    Science.gov (United States)

    Galvanauskas, Almantas

    2018-01-09

    A beam combining and pulse stacking technique is provided that enhances laser pulse energy by coherent stacking pulse bursts (i.e. non-periodic pulsed signals) in time domain. This energy enhancement is achieved by using various configurations of Fabry-Perot, Gires-Tournois and other types of resonant cavities, so that a multiple-pulse burst incident at either a single input or multiple inputs of the system produces an output with a solitary pulse, which contains the summed energy of the incident multiple pulses from all beams. This disclosure provides a substantial improvement over conventional coherent-combining methods in that it achieves very high pulse energies using a relatively small number of combined laser systems, thus providing with orders of magnitude reduction in system size, complexity, and cost compared to current combining approaches.

  20. On Combining Language Models: Oracle Approach

    National Research Council Canada - National Science Library

    Hacioglu, Kadri; Ward, Wayne

    2001-01-01

    In this paper, we address the of combining several language models (LMs). We find that simple interpolation methods, like log-linear and linear interpolation, improve the performance but fall short of the performance of an oracle...

  1. Combination Classes and "Hora de comunicacion."

    Science.gov (United States)

    Eldredge, Dee L.

    1989-01-01

    Ways to combine small classes of higher education students studying Spanish at various levels are described, including judicious use of language laboratories, staggering of the different level groups, and rotation of activities geared toward students' individual proficiency levels. (CB)

  2. Ameliorative Effects of Herbal Combinations in Hyperlipidemia

    Directory of Open Access Journals (Sweden)

    Nishant P. Visavadiya

    2011-01-01

    Full Text Available The roots of Glycyrrhiza glabra, Withania somnifera, Asparagus racemosus, and Chlorophytum borivilianum and seeds of Sesamum indicum are ayurvedic medicinal plants used in India to treat several ailments. Our previous studies indicated that these plants possess hypolipidemic and antioxidant potential. The present study was aimed at investigating the composite effects of these plants on hypercholesterolemic rats. Three different combinations (5 gm%, given for four weeks used in this study effectively reduced plasma and hepatic lipid profiles and increased fecal excretion of cholesterol, neutral sterol, and bile acid along with increasing the hepatic HMG-CoA reductase activity and bile acid content in hypercholesterolemic rats. Further, all three combinations also improved the hepatic antioxidant status (catalase, SOD, and ascorbic acid levels and plasma total antioxidant capacity with reduced hepatic lipid peroxidation. Overall, combination I had the maximum effect on hypercholesterolemic rats followed by combinations II and III due to varying concentrations of the different classes of phytocomponents.

  3. A Combined Preconditioning Strategy for Nonsymmetric Systems

    KAUST Repository

    Ayuso Dios, Blanca; Barker, A. T.; Vassilevski, P. S.

    2014-01-01

    of the additive Schwarz method applied to nonsymmetric but definite matrices is presented for which the abstract assumptions are verified. A variable preconditioner, combining the original nonsymmetric one and a weighted least-squares version of it, is shown

  4. Comparison of accounting methods for business combinations

    Directory of Open Access Journals (Sweden)

    Jaroslav Sedláček

    2012-01-01

    Full Text Available The revised accounting rules applicable to business combinations in force on July1st 2009, are the result of several years efforts the convergence of U.S. and International Committee of the Financial Accounting Standards. Following the harmonization of global accounting procedures are revised and implemented also Czech accounting regulations. In our research we wanted to see how changes can affect the strategy and timing of business combinations. Comparative analysis is mainly focused on the differences between U.S. and international accounting policies and Czech accounting regulations. Key areas of analysis and synthesis are the identification of business combination, accounting methods for business combinations and goodwill recognition. The result is to assess the impact of the identified differences in the reported financial position and profit or loss of company.

  5. Combined surface and volumetric occlusion shading

    KAUST Repository

    Schott, Matthias O.; Martin, Tobias; Grosset, A. V Pascal; Brownlee, Carson; Hollt, Thomas; Brown, Benjamin P.; Smith, Sean T.; Hansen, Charles D.

    2012-01-01

    In this paper, a method for interactive direct volume rendering is proposed that computes ambient occlusion effects for visualizations that combine both volumetric and geometric primitives, specifically tube shaped geometric objects representing streamlines, magnetic field lines or DTI fiber tracts. The proposed algorithm extends the recently proposed Directional Occlusion Shading model to allow the rendering of those geometric shapes in combination with a context providing 3D volume, considering mutual occlusion between structures represented by a volume or geometry. © 2012 IEEE.

  6. Object attributes combine additively in visual search

    OpenAIRE

    Pramod, R. T.; Arun, S. P.

    2016-01-01

    We perceive objects as containing a variety of attributes: local features, relations between features, internal details, and global properties. But we know little about how they combine. Here, we report a remarkably simple additive rule that governs how these diverse object attributes combine in vision. The perceived dissimilarity between two objects was accurately explained as a sum of (a) spatially tuned local contour-matching processes modulated by part decomposition; (b) differences in in...

  7. Simulation of a combined-cycle engine

    Science.gov (United States)

    Vangerpen, Jon

    1991-01-01

    A FORTRAN computer program was developed to simulate the performance of combined-cycle engines. These engines combine features of both gas turbines and reciprocating engines. The computer program can simulate both design point and off-design operation. Widely varying engine configurations can be evaluated for their power, performance, and efficiency as well as the influence of altitude and air speed. Although the program was developed to simulate aircraft engines, it can be used with equal success for stationary and automative applications.

  8. Osteogenesis imperfecta in combination with Graves disease

    Directory of Open Access Journals (Sweden)

    Marina S. Sheremeta

    2017-12-01

    Full Text Available Osteogenesis imperfecta (OI – is a group of genetically disorders, which are charaterized by a disturbed bone formation. In turn, the excess of thyroid hormones in Graves' disease (GD also posses a negative effect on bone tissue, thereby aggravating OI. That requires from the endocrinologist the most careful management of patients with the combination of these pathologies. In this article, we present a unique clinical case of a combination of GD and OI.

  9. Combining Stocks and Flows of Knowledge

    DEFF Research Database (Denmark)

    Ambos, Tina C.; Nell, Phillip Christopher; Pedersen, Torben

    2013-01-01

    While previous research has mostly focused on either knowledge stocks or knowledge flows, our study is among the first to integrate these perspectives in order to shed light on the complementarity effects of different types of knowledge stocks and flows in the multinational corporation (MNC...... of complementarity create benefits for these units, but that the effects from intra-functional combinations of knowledge stocks and flows are significantly stronger than from cross-functional combinations....

  10. Combined surface and volumetric occlusion shading

    KAUST Repository

    Schott, Matthias O.

    2012-02-01

    In this paper, a method for interactive direct volume rendering is proposed that computes ambient occlusion effects for visualizations that combine both volumetric and geometric primitives, specifically tube shaped geometric objects representing streamlines, magnetic field lines or DTI fiber tracts. The proposed algorithm extends the recently proposed Directional Occlusion Shading model to allow the rendering of those geometric shapes in combination with a context providing 3D volume, considering mutual occlusion between structures represented by a volume or geometry. © 2012 IEEE.

  11. [Using combined magnetotherapy in patients with acne].

    Science.gov (United States)

    Kul'chitskaia, D B; Orekhova, E M; Vasil'eva, E S

    2004-01-01

    Laser Doppler flowmetry discovered microcirculatory disorders in acne patients. Affected are arterioles as well as capillaries and venules. Combination of magnetotherapy with medication improves microcirculation in acne patients. More marked positive changes occurred in the microcirculatory system due to combined treatment compared to medication therapy only. Thus, laser Doppler flowmetry is a new, noninvasive method of assessing microcirculation in acne patients and can serve an objective criterion of treatment efficacy.

  12. Spectral coherent combination of ultrashort pulses

    International Nuclear Information System (INIS)

    Ursescu, D.; Banici, R.; Ionel, L.; Rusen, L.; Sandel, S.; Blanaru, C.

    2010-01-01

    Complete text of publication follows. The coherent beam combination was chosen in several laser systems, including ELI, as a solution to increase the final attainable intensity. However, the coherent beam combination it is also a difficult technique while it has to combine coherently in space and in time several beams amplified in different laser chains. That means in particular that the beams should be in phase in every point of the amplified beam so the spatial beam profiling techniques have to be mastered with high accuracy for all the combined beams. Here it is proposed an alternative coherent beam combination than the use of identical ultrashort pulses. The idea is to spectrally combine laser pulses with complementary spectra. Collinear and non-collinear approaches have been modelled. Ongoing experimental development, including the demonstration of the rephasing for two spectrally complementary ultrashort pulses will be presented. Acknowledgements. The research leading to these results has received funding from the EC's Seventh Framework Programme (LASERLAB-EUROPE, grant agreement no. 228334).

  13. Forecast Combination under Heavy-Tailed Errors

    Directory of Open Access Journals (Sweden)

    Gang Cheng

    2015-11-01

    Full Text Available Forecast combination has been proven to be a very important technique to obtain accurate predictions for various applications in economics, finance, marketing and many other areas. In many applications, forecast errors exhibit heavy-tailed behaviors for various reasons. Unfortunately, to our knowledge, little has been done to obtain reliable forecast combinations for such situations. The familiar forecast combination methods, such as simple average, least squares regression or those based on the variance-covariance of the forecasts, may perform very poorly due to the fact that outliers tend to occur, and they make these methods have unstable weights, leading to un-robust forecasts. To address this problem, in this paper, we propose two nonparametric forecast combination methods. One is specially proposed for the situations in which the forecast errors are strongly believed to have heavy tails that can be modeled by a scaled Student’s t-distribution; the other is designed for relatively more general situations when there is a lack of strong or consistent evidence on the tail behaviors of the forecast errors due to a shortage of data and/or an evolving data-generating process. Adaptive risk bounds of both methods are developed. They show that the resulting combined forecasts yield near optimal mean forecast errors relative to the candidate forecasts. Simulations and a real example demonstrate their superior performance in that they indeed tend to have significantly smaller prediction errors than the previous combination methods in the presence of forecast outliers.

  14. Exact analysis of Packet Reversed Packet Combining Scheme and Modified Packet Combining Scheme; and a combined scheme

    International Nuclear Information System (INIS)

    Bhunia, C.T.

    2007-07-01

    Packet combining scheme is a well defined simple error correction scheme for the detection and correction of errors at the receiver. Although it permits a higher throughput when compared to other basic ARQ protocols, packet combining (PC) scheme fails to correct errors when errors occur in the same bit locations of copies. In a previous work, a scheme known as Packet Reversed Packet Combining (PRPC) Scheme that will correct errors which occur at the same bit location of erroneous copies, was studied however PRPC does not handle a situation where a packet has more than 1 error bit. The Modified Packet Combining (MPC) Scheme that can correct double or higher bit errors was studied elsewhere. Both PRPC and MPC schemes are believed to offer higher throughput in previous studies, however neither adequate investigation nor exact analysis was done to substantiate this claim of higher throughput. In this work, an exact analysis of both PRPC and MPC is carried out and the results reported. A combined protocol (PRPC and MPC) is proposed and the analysis shows that it is capable of offering even higher throughput and better error correction capability at high bit error rate (BER) and larger packet size. (author)

  15. Throughput of Type II HARQ-OFDM/TDM Using MMSE-FDE in a Multipath Channel

    Directory of Open Access Journals (Sweden)

    Haris Gacanin

    2009-01-01

    Full Text Available In type II hybrid ARQ (HARQ schemes, the uncoded information bits are transmitted first, while the error correction parity bits are sent upon request. Consequently, frequency diversity cannot be exploited during the first transmission. In this paper, we present the use of OFDM/TDM with MMSE-FDE and type II HARQ to increase throughput of OFDM due to frequency diversity gain.

  16. Joint Coding/Decoding for Multi-message HARQ

    OpenAIRE

    Benyouss , Abdellatif; Jabi , Mohammed; Le Treust , Maël; Szczecinski , Leszek

    2016-01-01

    International audience; In this work, we propose and investigate a new coding strategy devised to increase the throughput of hybrid ARQ (HARQ) transmission over block fading channel. In our proposition, the transmitter jointly encodes a variable number of bits for each round of HARQ. The parameters (rates) of this joint coding can vary and may be based on the negative acknowledgment (NACK) signals provided by the receiver or, on the past (outdated) information about the channel states. The re...

  17. On the TDD Subframe Structure for Beyond 4G Radio Access Network

    DEFF Research Database (Denmark)

    Lähetkangas, Eeva; Pajukoski, Kari; Tiirola, Esa

    2013-01-01

    The purpose of a Beyond 4G (B4G) radio access technology, is to cope with the expected exponential increase of mobile data traffic in local area (LA). The requirements related to physical layer control signaling latencies and to hybrid ARQ (HARQ) round trip time (RTT) are in the order of ~1ms...... requirement and significant control signaling latency reductions compared to existing LTE-Advanced and WiMAX technologies....

  18. Combined precut in difficult biliary cannulation

    Directory of Open Access Journals (Sweden)

    Jesús Espinel-Díez

    2013-06-01

    Full Text Available Aim: precut sphincterotomy refers to a variety of endoscopic techniques that are used in order to access the bile duct when conventional methods of cannulation have failed. There are not significant data (such as efficacy, safety about the use of different techniques of precutting at the same session. We have described our experience with combined precut sphincterotomy (CPS and we have compared our results to the use of an isolated precut. Patients and methods: we have performed 247 precuts of a total of 2.390 ERCPs. Patients were distributed according to the type of precut practiced: Needle-knife, transpancreatic and combined precut sphincterotomies. "Combined precut" consisted in performing first a transpancreatic sphincterotomy and, if the access was not achieved, then performing a needle-knife sphincterotomy in the same session. The data about safety and efficacy were prospectively collected. The complications were defined according to the consensus criteria. Results: we performed precutting techniques in 247 patients. Needle-knife, transpancreatic, and combined precuts were performed in 125 (6.9%, 74 (4.1% and 48 (2.6% patients, respectively. Bile duct cannulation was successful in 48 patients (100% in the group of combined precut, 121 patients (96.8% in the transpancreatic group, and 67 patients (90.5% in the needle-knife group (p = 0.03. There were not differences in complications rates between the three groups. There was no pancreatitis in the combined precut group. The complications were successfully managed with conservative treatment. Conclusions: combined precut sphincterotomy seems to be a safe and successful technique in those cases of difficult bile duct cannulation.

  19. [Combination drug therapy in patients with BPH].

    Science.gov (United States)

    Kuzmenko, A V; Kuzmenko, V V; Gyaurgiev, T A

    2018-03-01

    Introuction. One of the risk factors for LUTS is an infravesical obstruction, which is most often caused by benign prostatic hyperplasia (BPH). BPH symptoms are formed due to three components: static (mechanical), dynamic, and impaired functional capacity of the bladder. Medical treatment with 1-blockers decreases the outflow obstruction. 5-alpha reductase inhibitors are used to inhibit the static component of BPH. To investigate the effectiveness of various modifications of medical therapy of BPH using -blockers and 5-reductase inhibitors and combinations thereof. The study comprised 90 BPH patients who were divided into three groups, with each group containing 30 people. Patients of group I, II and III received monotherapy with -blockers, a combination of 5-reductase and -blockers, and fixed-dose combination drug Duodart, respectively. Evaluation of the treatment effectiveness included filling out voiding diaries, completing the I-PSS and QL questionnaires, uroflowmetry, transrectal ultrasonography of the prostate and estimation of the incidence of adverse effects. Also, compliance with the treatment was evaluated, and the number of patients who had episodes of acute urinary retention and required surgical treatment during the 12 month treatment course was registered. Compared to monotherapy, combination therapy with -blockers and 5-reductase inhibitors more effectively reduces the LUTS, increases Qmax and prevents the disease progression, which manifests in a lower incidence of AUR and fewer surgical interventions in groups II and III. However, the combination therapy can be associated with some side effects. Patients who received fixed-dose combination drug Duodart had a greater compliance rate than patients on the combination of drugs, which, in our opinion, is associated with fewer cases of AUR and surgical interventions. The use of Duodart in patients with BPH effectively alleviates LUTS and reduces the risk of the disease progression, which manifests itself

  20. The danger of fixed drug combinations.

    Science.gov (United States)

    Herxheimer, H

    1975-07-01

    After the second world war a number of pharmaceutical firms which were not able to create new therapeutic substances by their own research, put a great number of fixed drug combinations on the market. Their number quickly increased, as the efficiency of these compounds required no legal proof and as, with appropriate propaganda, large profits could be earned. The number of firms doing this sort of production also increased, and in West Germany, for instance, more than 3/4 of all drugs on the official list are now fixed combinations. Our task is, therefore, to ask for regulations which limit fixed combinations to such preparation the efficiency of which has been shown and whose advantages more than outweigh their disadvantages. The advantages of these preparations are convenience to the patient, avoidance of potential mistakes made possible by too many drugs given on the same day and, perhaps, lower prices. The disadvantages are: 1. The individual optimum dose for a patient cannot be achieved, because in case of a change of dosis all components are changed. 2. Different components may have different duration of action. 3. Different components may have a different bioavailability. 4. Different components may interact. 5. Some components may create tolerance, others not. In many cases fixed combinations have been used to make drugs with poor efficiency financially viable by combining them with very efficient drugs. The existence of thousands of fixed combinations makes the drug market indiscernible and useless. They obscure the relatively few essential drugs and make it difficult for the doctor to find his way amongst the mass of offered medicaments. Few fixed combinations are justifiable. These are well known and they should be permitted as before. All others should be banned until it has been shown that their advantages are greater than their disadvantages.

  1. Estimation of structural reliability under combined loads

    International Nuclear Information System (INIS)

    Shinozuka, M.; Kako, T.; Hwang, H.; Brown, P.; Reich, M.

    1983-01-01

    For the overall safety evaluation of seismic category I structures subjected to various load combinations, a quantitative measure of the structural reliability in terms of a limit state probability can be conveniently used. For this purpose, the reliability analysis method for dynamic loads, which has recently been developed by the authors, was combined with the existing standard reliability analysis procedure for static and quasi-static loads. The significant parameters that enter into the analysis are: the rate at which each load (dead load, accidental internal pressure, earthquake, etc.) will occur, its duration and intensity. All these parameters are basically random variables for most of the loads to be considered. For dynamic loads, the overall intensity is usually characterized not only by their dynamic components but also by their static components. The structure considered in the present paper is a reinforced concrete containment structure subjected to various static and dynamic loads such as dead loads, accidental pressure, earthquake acceleration, etc. Computations are performed to evaluate the limit state probabilities under each load combination separately and also under all possible combinations of such loads. Indeed, depending on the limit state condition to be specified, these limit state probabilities can indicate which particular load combination provides the dominant contribution to the overall limit state probability. On the other hand, some of the load combinations contribute very little to the overall limit state probability. These observations provide insight into the complex problem of which load combinations must be considered for design, for which limit states and at what level of limit state probabilities. (orig.)

  2. Energy Analysis in Combined Reforming of Propane

    Directory of Open Access Journals (Sweden)

    K. Moon

    2013-01-01

    Full Text Available Combined (steam and CO2 reforming is one of the methods to produce syngas for different applications. An energy requirement analysis of steam reforming to dry reforming with intermediate steps of steam reduction and equivalent CO2 addition to the feed fuel for syngas generation has been done to identify condition for optimum process operation. Thermodynamic equilibrium data for combined reforming was generated for temperature range of 400–1000°C at 1 bar pressure and combined oxidant (CO2 + H2O stream to propane (fuel ratio of 3, 6, and 9 by employing the Gibbs free energy minimization algorithm of HSC Chemistry software 5.1. Total energy requirement including preheating and reaction enthalpy calculations were done using the equilibrium product composition. Carbon and methane formation was significantly reduced in combined reforming than pure dry reforming, while the energy requirements were lower than pure steam reforming. Temperatures of minimum energy requirement were found in the data analysis of combined reforming which were optimum for the process.

  3. Combined Medical Treatment Of Chronic Pancreatitis

    Directory of Open Access Journals (Sweden)

    Umnova Larisa

    2015-04-01

    Full Text Available The aim of the study was to determine the most effective medical treatment of patients with chronic pancreatitis, by using either pancreatin alone or in combination with proton pump inhibitor (PPI or PPI and non-steroidal anti-inflammatory drug (NSAID. Patients with chronic pancreatitis, who did not require a surgical treatment, received medical treatment for a one–month period: 20 patients received pancreatin monotherapy; 48 patients were given a combination of pancreatin and PPI; 38 patients were treated with a combination of pancreatin, PPI and NSAID (PNP therapy group. In comparison with other groups, patients in the PNP therapy group showed improvement in body mass index, abdominal pain, bowel movements, chronic pancreatitis severity, as well as their quality of life assessment (p < 0.05. The combination of pancreatin, PPI and NSAID was the most effective among those applied in chronic pancreatitis patient treatment. A one–month long course of this therapy was safe and did not cause any significant adverse effects. The combination of pancreatin, PPI and NSAID for treatment of chronic pancreatitis can be recommended, as it is based on pathogenesis of the disease, effective, safe and economically advantageous.

  4. OT-Combiners Via Secure Computation

    DEFF Research Database (Denmark)

    Harnik, Danny; Ishai, Yuval; Kushilevitz, Eyal

    2008-01-01

    of faulty candidates (t = Ω(n)). Previous OT-combiners required either ω(n) or poly(k) calls to the n candidates, where k is a security parameter, and produced only a single secure OT. We demonstrate the usefulness of the latter result by presenting several applications that are of independent interest......An OT-combiner implements a secure oblivious transfer (OT) protocol using oracle access to n OT-candidates of which at most t may be faulty. We introduce a new general approach for combining OTs by making a simple and modular use of protocols for secure computation. Specifically, we obtain an OT......, strengthen the security, and improve the efficiency of previous OT-combiners. In particular, we obtain the first constant-rate OT-combiners in which the number of secure OTs being produced is a constant fraction of the total number of calls to the OT-candidates, while still tolerating a constant fraction...

  5. Bifuel coal-gas combined cycles

    International Nuclear Information System (INIS)

    Chmielniak, Tadeusz; Kotowicz, Janusz; Lyczko, Jacek

    1997-01-01

    This paper describes basic ways of realization of bi fuel cool-gas combined cycles. The criterion of classification of the systems specification is a joint of the gas pail with the steam part: a) The gas turbine flue gases are introduced into the steam boiler combustion chamber (the serial, hot wind box). b) Bypass of the beat exchangers at the steam turbine unit and/or the steam boiler, by use the waste heat exchangers, or waste boiler at the gas turbine unit (the parallel-coupled). c) The mixed, it's a combination of the two upper. The analysis of the parallel system has been specially presented. In derived formulas for the total efficiency of the bi fuel parallel combined cycle balance equations have been used. This formulas can be used for planning new combined cycle power plants and for modernization existing steam power plants. It was made a discussion about influence of the ratio the gas and the steam turbine electric power on the cycle efficiency in care of the full and the part load of the bi fuel combined cycle power plant. The various systems of the joint of the gas part with the steam part have been examined. The selected results of the calculations have been attached. The models and the numerical simulations have been based on data from the existing steam power plants and real gas turbine units. (Author)

  6. Intravenous digital subtraction angiography of the lower limbs combined with field movement (2-field DSA)

    International Nuclear Information System (INIS)

    Fritschy, P.; Terrier, F.

    1988-01-01

    We evaluated a bolus-chase technique designed to reduce the volume of contrast material and to shorten examination time during intravenous digital subtraction angiography (IV-DSA) of the lower limbs. With this technique, after a single injection of contrast material, two contiguous fields can be sequentially imaged (two-field DAS) using a step translated X-ray tube. 67 patients with peripheral vascular disease were studied. All examinations provided diagnostic information, so that in no instance additional intra-arterial injections were required. With the two-field DSA only 3.49 injections were needed in the average for five fields examined in each patient, resulting in a 30% reduction of contrast agent used. (orig.) [de

  7. Coherent combination of ultrafast fiber amplifiers

    International Nuclear Information System (INIS)

    Hanna, Marc; Guichard, Florent; Druon, Frédéric; Georges, Patrick; Zaouter, Yoann; Papadopoulos, Dimitris N

    2016-01-01

    We review recent progress in coherent combining of femtosecond pulses amplified in optical fibers as a way to scale the peak and average power of ultrafast sources. Different methods of achieving coherent pulse addition in space (beam combining) and time (divided pulse amplification) domains are described. These architectures can be widely classified into active methods, where the relative phases between pulses are subject to a servomechanism, and passive methods, where phase matching is inherent to the geometry. Other experiments that combine pulses with different spectral contents, pulses that have been nonlinearly broadened or successive pulses from a mode-locked laser oscillator, are then presented. All these techniques allow access to unprecedented parameter range for fiber ultrafast sources. (topical review)

  8. Efficient power combiner for THz radiation

    Energy Technology Data Exchange (ETDEWEB)

    Seidfaraji, Hamide, E-mail: hsfaraji@unm.edu; Fuks, Mikhail I.; Christodoulou, Christos; Schamiloglu, Edl [Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, 87131-0001 (United States)

    2016-08-15

    Most dangerous explosive materials, both toxic and radioactive, contain nitrogen salts with resonant absorption lines in the frequency range 0.3-10 THz. Therefore, there has been growing interest in remotely detecting such materials by observing the spectrum of reflected signals when the suspicious material is interrogated by THz radiation. Practical portable THz sources available today generate only 20–40 mW output power. This power level is too low to interrogate suspicious material from a safe distance, especially if the material is concealed. Hence, there is a need for sources that can provide greater power in the THz spectrum. Generating and extracting high output power from THz sources is complicated and inefficient. The efficiency of vacuum electronic microwave sources is very low when scaled to the THz range and THz sources based on scaling down semiconductor laser sources have low efficiency as well, resulting in the well known “THz gap.” The reason for such low efficiencies for both source types is material losses in the THz band. In this article an efficient power combiner is described that is based on scaling to higher frequencies a microwave combiner that increases the output power in the THz range of interest in simulation studies. The proposed power combiner not only combines the THz power output from several sources, but can also form a Gaussian wavebeam output. A minimum conversion efficiency of 89% with cophased inputs in a lossy copper power combiner and maximum efficiency of 100% in a Perfect Electric Conductor (PEC)-made power combiner were achieved in simulations. Also, it is shown that the TE{sub 01} output mode is a reasonable option for THz applications due to the fact that conductive loss decreases for this mode as frequency increases.

  9. Efficient power combiner for THz radiation

    Directory of Open Access Journals (Sweden)

    Hamide Seidfaraji

    2016-08-01

    Full Text Available Most dangerous explosive materials, both toxic and radioactive, contain nitrogen salts with resonant absorption lines in the frequency range 0.3-10 THz. Therefore, there has been growing interest in remotely detecting such materials by observing the spectrum of reflected signals when the suspicious material is interrogated by THz radiation. Practical portable THz sources available today generate only 20–40 mW output power. This power level is too low to interrogate suspicious material from a safe distance, especially if the material is concealed. Hence, there is a need for sources that can provide greater power in the THz spectrum. Generating and extracting high output power from THz sources is complicated and inefficient. The efficiency of vacuum electronic microwave sources is very low when scaled to the THz range and THz sources based on scaling down semiconductor laser sources have low efficiency as well, resulting in the well known “THz gap.” The reason for such low efficiencies for both source types is material losses in the THz band. In this article an efficient power combiner is described that is based on scaling to higher frequencies a microwave combiner that increases the output power in the THz range of interest in simulation studies. The proposed power combiner not only combines the THz power output from several sources, but can also form a Gaussian wavebeam output. A minimum conversion efficiency of 89% with cophased inputs in a lossy copper power combiner and maximum efficiency of 100% in a Perfect Electric Conductor (PEC-made power combiner were achieved in simulations. Also, it is shown that the TE01 output mode is a reasonable option for THz applications due to the fact that conductive loss decreases for this mode as frequency increases.

  10. Artificial intelligence in drug combination therapy.

    Science.gov (United States)

    Tsigelny, Igor F

    2018-02-09

    Currently, the development of medicines for complex diseases requires the development of combination drug therapies. It is necessary because in many cases, one drug cannot target all necessary points of intervention. For example, in cancer therapy, a physician often meets a patient having a genomic profile including more than five molecular aberrations. Drug combination therapy has been an area of interest for a while, for example the classical work of Loewe devoted to the synergism of drugs was published in 1928-and it is still used in calculations for optimal drug combinations. More recently, over the past several years, there has been an explosion in the available information related to the properties of drugs and the biomedical parameters of patients. For the drugs, hundreds of 2D and 3D molecular descriptors for medicines are now available, while for patients, large data sets related to genetic/proteomic and metabolomics profiles of the patients are now available, as well as the more traditional data relating to the histology, history of treatments, pretreatment state of the organism, etc. Moreover, during disease progression, the genetic profile can change. Thus, the ability to optimize drug combinations for each patient is rapidly moving beyond the comprehension and capabilities of an individual physician. This is the reason, that biomedical informatics methods have been developed and one of the more promising directions in this field is the application of artificial intelligence (AI). In this review, we discuss several AI methods that have been successfully implemented in several instances of combination drug therapy from HIV, hypertension, infectious diseases to cancer. The data clearly show that the combination of rule-based expert systems with machine learning algorithms may be promising direction in this field. © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  11. Combined air and water pollution control system

    Science.gov (United States)

    Wolverton, Billy C. (Inventor); Jarrell, Lamont (Inventor)

    1990-01-01

    A bioaquatic air pollution control system for controlling both water and atmospheric pollution is disclosed. The pollution control system includes an exhaust for directing polluted gases out of a furnace and a fluid circulating system which circulates fluid, such as waste water, from a source, past the furnace where the fluid flow entrains the pollutants from the furnace. The combined fluid and pollutants are then directed through a rock/plant/microbial filtering system. A suction pump pumps the treated waste water from the filter system past the exhaust to again entrain more pollutants from the furnace where they are combined with the fluid (waste water) and directed to the filter system.

  12. Combined treatment for complex intracranial aneurysm

    Directory of Open Access Journals (Sweden)

    Chiriac A.

    2015-06-01

    Full Text Available Complex aneurysms often cannot be completely excluded by a single approaches. Today successful treatment of these lesions requires a combination between microsurgical and endovascular techniques. Planning of combined treatment require a very good understanding of aneurysm anatomy and a close collaboration between neurosurgeon and neuroendovascular interventionist. Endovascular coiling can usually be used as early treatment for a partially aneurysm occlusion including the ruptured area and followed by definitive clipping. On the other hand microsurgical clipping also can be used as first treatment for complex aneurysm neck reconstruction, allowing successful secondary placement of coils inside the remnant aneurysm sac

  13. Raman beam combining for laser brightness enhancement

    Science.gov (United States)

    Dawson, Jay W.; Allen, Graham S.; Pax, Paul H.; Heebner, John E.; Sridharan, Arun K.; Rubenchik, Alexander M.; Barty, Chrisopher B. J.

    2015-10-27

    An optical source capable of enhanced scaling of pulse energy and brightness utilizes an ensemble of single-aperture fiber lasers as pump sources, with each such fiber laser operating at acceptable pulse energy levels. Beam combining involves stimulated Raman scattering using a Stokes' shifted seed beam, the latter of which is optimized in terms of its temporal and spectral properties. Beams from fiber lasers can thus be combined to attain pulses with peak energies in excess of the fiber laser self-focusing limit of 4 MW while retaining the advantages of a fiber laser system of high average power with good beam quality.

  14. Maximisation of Combined Cycle Power Plant Efficiency

    Directory of Open Access Journals (Sweden)

    Janusz Kotowicz

    2015-12-01

    Full Text Available The paper presents concepts for increasing the efficiency of a modern combined cycle power plant. Improvement of gas turbine performance indicators as well as recovering heat from the air cooling the gas turbine’s flow system enable reaching gross electrical efficiencies of around 65%. Analyses for a wide range of compressor pressure ratios were performed. Operating characteristics were developed for the analysed combined cycle plant, for different types of open air cooling arrangements of the gas turbine’s expander: convective, transpiration and film.

  15. Clinical application of radiotherapy combined with chemotherapy

    International Nuclear Information System (INIS)

    Morita, Kozo

    1978-01-01

    In clinical application of radiation therapy combined with chemotherapy, it is important to gain the maximal therapeutic benefit. At present we have no agents that improve the therapeutic ratio by enhancing the effect of radiation on the tumor cell selectively. Therefore, it is necessary to use combining some or all of following procedures: (1) the intraarterial infusion of the agents, (2) the selective localization by reason of the biological affinity of the agents, (3) the surgical removal of the non-sensitized tumor residue and (4) the selective sensitization of the tumor due to its shorter cell cycle. (author)

  16. Suction caissons subjected to monotonic combined loading

    DEFF Research Database (Denmark)

    Penzes, P.; Jensen, M.R.; Zania, Varvara

    2016-01-01

    Suction caissons are being increasingly used as offshore foundation solutions in shallow and intermediate water depths. The convenient installation method through the application of suction has rendered this type of foundation as an attractive alternative to the more traditional monopile foundation...... for offshore wind turbines. The combined loading imposed typically to a suction caisson has led to the estimation of their bearing capacity by means of 3D failure envelopes. This study aims to analyse the behaviour of suction caissons for offshore wind turbines subjected to combined loading. Finite element...

  17. RF torch discharge combined with conventional burner

    International Nuclear Information System (INIS)

    Janca, J.; Tesar, C.

    1996-01-01

    The design of the combined flame-rf-plasma reactor and experimental examination of this reactor are presented. For the determination of the temperature in different parts of the combined burner plasma the methods of emission spectroscopy were used. The temperatures measured in the conventional burner reach the maximum temperature 1900 K but in the burner with the superimposed rf discharge the neutral gas temperature substantially increased up to 2600 K but also the plasma volume increases substantially. Consequently, the resident time of reactants in the reaction zone increases

  18. Diagnostic system for combine cycle power plant

    International Nuclear Information System (INIS)

    Shimizu, Yujiro; Nomura, Masumi; Tanaka, Satoshi; Ito, Ryoji; Kita, Yoshiyuki

    2000-01-01

    We developed the Diagnostic System for Combined Cycle Power Plant which enables inexperienced operators as well as experienced operators to cope with abnormal conditions of Combined Cycle Power Plant. The features of this system are the Estimate of Emergency Level for Operation and the Prediction of Subsequent Abnormality, adding to the Diagnosis of Cause and the Operation Guidance. Moreover in this system, Diagnosis of Cause was improved by using our original method and support screens can be displayed for educational means in normal condition as well. (Authors)

  19. Combined utilization of biogas and natural gas

    International Nuclear Information System (INIS)

    Jensen, J.; Tafdrup, S.; Christensen, J.

    1997-01-01

    The Danish natural gas network has been established during the past 10 years. Running parallel with this a small but growing production of biogas from centralized biogas plants and landfills has been developed. The annual biogas production is expected to keep growing and increase tenfold in the next 25 year period with a reduction of green house gas emissions as one of the important incentives. The last years' development and expansion of the Danish biogas sector has shown a need for combined utilization of biogas and natural gas. If larger volumes of biogas are present, upgrading and distribution by the natural gas network may be an alternative to combined utilization. (au) 12 refs

  20. PANSAID-PAracetamol and NSAID in combination

    DEFF Research Database (Denmark)

    Thybo, Kasper Højgaard; Jakobsen, Janus Christian; Hägi-Pedersen, Daniel

    2017-01-01

    BACKGROUND: Effective postoperative pain management is essential for the rehabilitation of the surgical patient. The PANSAID trial evaluates the analgesic effects and safety of the combination of paracetamol and ibuprofen. This paper describes in detail the statistical analysis plan for the primary...... publication to prevent outcome reporting bias and data-driven analysis results. METHODS/DESIGN: The PANSAID trial is a multicentre, randomised, controlled, parallel, four-group clinical trial comparing the beneficial and harmful effects of different doses and combinations of paracetamol and ibuprofen...... of paracetamol and ibuprofen used in a perioperative setting. TRIAL REGISTRATION: ClinicalTrials.org identifier: NCT02571361 . Registered on 7 October 2015....

  1. Combined modality treatment with radiotherapy and chemotherapy

    International Nuclear Information System (INIS)

    Tannock, I.F.; Toronto Univ., ON

    1989-01-01

    The present paper discusses some of the methodological issues which can confound the interpretation of clinical trials of combined modality treatment. It reviews some of the larger randomized trials which have evaluated combined modality treatment in cancers of the head and neck, lung, gastrointestinal tract and bladder. It concludes that adequate trials have yet to be performed in many of thses sites, but that at present, evidence for long-term benefit from adjunctivechemotherapy is meagre. Finally, it suggests some possible mechanisms which might heve limited the benefit of chemotherapy when added to radiation treatment. (Author). 87 refs.; 4 figs.; 4 tabs

  2. Combined effect of external and internal irradiation

    International Nuclear Information System (INIS)

    Kiradzhiev, G.

    1987-01-01

    Some of the general regularities of the combined effect of external irradiation and iodine 131 are discussed. Data are adduced showing that modification of the effects of these two radiation factors, when jointly applied, is also determined by the quantitative relations of the applied doses of external and internal irradiation, referred to a particular moment of the effects. It was shown that the effects of the radionuclides in these combined radiation injuries are basically realized by two mechanisms: 1. changes are found in the radionuclide kinetic parameters (nonspecific effects); 2. changes in their kinetic parameters are absent (specific effect). These two mechanisms underlie different approaches to therapy

  3. Chemotherapy in combined and multimodality treatment

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    It is shown that chemotherapy of tumors of various localizations developes intensively in the last few years. It is connected with discovery and adoption of new active antitumoral preparations, such as alkylating preparations, antimetabolites, antitumoral antibiotics, hormonal preparations. To create the rational effective conditions of chemotherapy a study was made on kinetics of tumor gowth, molecular mechanisms of interaction of cytostatics and cells of malignant tumor. Main factors of chemotherapy combination with radiotherapy when treating numerous malignant tumors were considered. Effectiveness of using chemotherapy in combination with other methods of treatment was shown

  4. Combining Land Capability Evaluation, Geographic Information ...

    African Journals Online (AJOL)

    Combining Land Capability Evaluation, Geographic Information Systems, AnD Indigenous Technologies for Soil Conservation in Northern Ethiopia. ... Land capability and land use status were established following the procedures of a modified treatment-oriented capability classification using GIS. The case study ...

  5. Experimenting with new combinations of old ideas

    NARCIS (Netherlands)

    Linde, J.

    2012-01-01

    Many important (economic) decisions involve risk. At the same time every decision is made within a social context. So far (experimental) research studies these two aspects in isolation from each other. Jona Linde therefore combines existing experimental protocols to examine the influence of social

  6. Rocket Based Combined Cycle (RBCC) engine inlet

    Science.gov (United States)

    2004-01-01

    Pictured is a component of the Rocket Based Combined Cycle (RBCC) engine. This engine was designed to ultimately serve as the near term basis for Two Stage to Orbit (TSTO) air breathing propulsion systems and ultimately a Single Stage to Orbit (SSTO) air breathing propulsion system.

  7. Combined Heat and Power and Emissions Trading

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    The aim of this IEA Information Paper is to help policy makers and other stakeholders understand the challenges facing the incorporation of high efficiency combined heat and power (CHP) into greenhouse gas (GHG) Emissions Trading Schemes (ETSs) -- and to propose options for overcoming them.

  8. A Novel in situ Trigger Combination Method

    International Nuclear Information System (INIS)

    Buzatu, Adrian; Warburton, Andreas; Krumnack, Nils; Yao, Wei-Ming

    2012-01-01

    Searches for rare physics processes using particle detectors in high-luminosity colliding hadronic beam environments require the use of multi-level trigger systems to reject colossal background rates in real time. In analyses like the search for the Higgs boson, there is a need to maximize the signal acceptance by combining multiple different trigger chains when forming the offline data sample. In such statistically limited searches, datasets are often amassed over periods of several years, during which the trigger characteristics evolve and their performance can vary significantly. Reliable production cross-section measurements and upper limits must take into account a detailed understanding of the effective trigger inefficiency for every selected candidate event. We present as an example the complex situation of three trigger chains, based on missing energy and jet energy, to be combined in the context of the search for the Higgs (H) boson produced in association with a W boson at the Collider Detector at Fermilab (CDF). We briefly review the existing techniques for combining triggers, namely the inclusion, division, and exclusion methods. We introduce and describe a novel fourth in situ method whereby, for each candidate event, only the trigger chain with the highest a priori probability of selecting the event is considered. The in situ combination method has advantages of scalability to large numbers of differing trigger chains and of insensitivity to correlations between triggers. We compare the inclusion and in situ methods for signal event yields in the CDF WH search.

  9. MANUAL: REAL TIME CONTROL OF COMBINED SEWERS

    Science.gov (United States)

    Managers, engineers, and operators of combined urban sewer systems are faced with difficult problems related to the operation and maintenance of their facilities. In addition to the issues related to the operation and upkeep of the system, many sewerage agencies are facing increa...

  10. 77 FR 60418 - Combined Notice of Filings

    Science.gov (United States)

    2012-10-03

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings...-1064-000. Applicants: Venice Gathering System, L.L.C. Description: NAESB 2.0 Compliance Filing to be...

  11. 77 FR 71408 - Combined Notice of Filings

    Science.gov (United States)

    2012-11-30

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings....m. ET 12/3/12. Docket Numbers: RP13-301-000. Applicants: Venice Gathering System, LLC. Description...

  12. 76 FR 61352 - Combined Notice of Filings

    Science.gov (United States)

    2011-10-04

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings....m. Eastern Time on Wednesday, October 05, 2011. Docket Numbers: RP11-2585-000. Applicants: Venice...

  13. 76 FR 55375 - Combined Notice of Filings

    Science.gov (United States)

    2011-09-07

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings..., September 12, 2011. Docket Numbers: RP11-2454-000. Applicants: Venice Gathering System, LLC. Description...

  14. 75 FR 39230 - Combined Notice of Filings

    Science.gov (United States)

    2010-07-08

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings July 1, 2010. Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report..., July 12, 2010. Docket Numbers: RP10-922-000. Applicants: Venice Gathering System, LLC. Description...

  15. 76 FR 353 - Combined Notice of Filings

    Science.gov (United States)

    2011-01-04

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings December 22, 2010. Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund... 3, 2011. Docket Numbers: RP11-1640-000. Applicants: Venice Gathering System, L.L.C. Description...

  16. 78 FR 50408 - Combined Notice of Filings

    Science.gov (United States)

    2013-08-19

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings... Numbers: RP13-1239-000. Applicants: Venice Gathering System, L.L.C. Description: Order No. 776 Compliance...

  17. 76 FR 39085 - Combined Notice of Filings

    Science.gov (United States)

    2011-07-05

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings..., July 05, 2011. Docket Numbers: RP11-2205-000. Applicants: Venice Gathering System, LLC. Description...

  18. A combined experimental and theoretical study

    Indian Academy of Sciences (India)

    A combined theoretical and experimental study was also performed, which demonstrated that the clus- ters 1–3 with ... silica gel TLC plates (MERCK TLC Plates). The NMR .... tronic μ3-Se and maintains the same number of clus- ter valance ...

  19. Combinational Services for NGN based IPTV

    NARCIS (Netherlands)

    Mikóczy, E.; Schumann, S.; Stokking, H.M.; Deventer, M.O. van; Niamut, O.A.

    2009-01-01

    This paper describes the general concept of combinational/blended services for IP-based Television (IPTV) services in next generation networks towards its service oriented architecture concept (SOA). Besides introducing general approaches of service reusability (SOA concepts), the service enables

  20. Combined PET/MR imaging in neurology

    DEFF Research Database (Denmark)

    Andersen, Flemming Littrup; Ladefoged, Claes Nøhr; Beyer, Thomas

    2014-01-01

    AIM: Combined PET/MR systems have now become available for clinical use. Given the lack of integrated standard transmission (TX) sources in these systems, attenuation and scatter correction (AC) must be performed using the available MR-images. Since bone tissue cannot easily be accounted for duri...

  1. Cotard syndrome with catatonia: unique combination.

    Science.gov (United States)

    Basu, Aniruddha; Singh, Priti; Gupta, Rajiv; Soni, Sandeep

    2013-07-01

    Cotard syndrome is a rare psychiatric condition characterized by extreme nihilistic delusions. Catatonia though common, its combination with the Cotard syndrome is exceeding rare and more so the response with the pharmacotherapy as in our case. Since, both are found in organic conditions the importance of studying such a case is to understand the underlying neurobiologic determinants.

  2. Cotard Syndrome with Catatonia: Unique Combination

    OpenAIRE

    Basu, Aniruddha; Singh, Priti; Gupta, Rajiv; Soni, Sandeep

    2013-01-01

    Cotard syndrome is a rare psychiatric condition characterized by extreme nihilistic delusions. Catatonia though common, its combination with the Cotard syndrome is exceeding rare and more so the response with the pharmacotherapy as in our case. Since, both are found in organic conditions the importance of studying such a case is to understand the underlying neurobiologic determinants.

  3. Development Activities on Airbreathing Combined Cycle Engines

    Science.gov (United States)

    McArthur, J. Craig; Lyles, Garry (Technical Monitor)

    2000-01-01

    Contents include the following: Advanced reusable transportation(ART); aerojet and rocketdyne tests, RBCC focused concept flowpaths,fabricate flight weigh, test select components, document ART project, Istar (Integrated system test of an airbreathing rocket); combined cycle propulsion testbed;hydrocarbon demonstrator tracebility; Istar engine system and vehicle system closure study; and Istar project planning.

  4. Estimated combined steady state tyre slip characteristics

    NARCIS (Netherlands)

    Fernandez, A.L.A.; Pauwelussen, J.P.

    2001-01-01

    Excessive behaviour of vehicles is often the subject of study, motivated by either the development of active safety systems uch as ESP, or the improvement of vehicle performance such as for racecars. In all of these cases, combined slip needs to be taken into account. In many cases however, the full

  5. Combined effect between two functional polymorphisms of ...

    Indian Academy of Sciences (India)

    four populations (Ireland, UK, Australia and Finland) reported an allelic association between ... of two common polymorphisms on SLC6A12 gene may be associated with TLE, but the ... Li L., Liu A., Wu X., Sun W., Wang Y. and Liu Y. 2015 Combined effect between two ... epileptic control subjects of Chinese Han origin were.

  6. Combined antiretroviral and anti- tuberculosis drug resistance ...

    African Journals Online (AJOL)

    these epidemics, many challenges remain.[3] Antiretroviral and anti-TB drug resistance pose considerable threats to the control of these epidemics.[4,5]. The breakdown in HIV/TB control within prisons is another emerging threat.[6,7] We describe one of the first reports of combined antiretroviral and anti-TB drug resistance ...

  7. 77 FR 27221 - Combined Notice of Filings

    Science.gov (United States)

    2012-05-09

    ... Generator Status of Minonk Wind, LLC. Filed Date: 4/19/12. Accession Number: 20120419-5196. Comments Due: 5... Self-Certification of Exempt Wholesale Generator Status of Senate Wind, LLC. Filed Date: 4/19/12... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice...

  8. Combination of scoring schemes for protein docking

    Directory of Open Access Journals (Sweden)

    Schomburg Dietmar

    2007-08-01

    Full Text Available Abstract Background Docking algorithms are developed to predict in which orientation two proteins are likely to bind under natural conditions. The currently used methods usually consist of a sampling step followed by a scoring step. We developed a weighted geometric correlation based on optimised atom specific weighting factors and combined them with our previously published amino acid specific scoring and with a comprehensive SVM-based scoring function. Results The scoring with the atom specific weighting factors yields better results than the amino acid specific scoring. In combination with SVM-based scoring functions the percentage of complexes for which a near native structure can be predicted within the top 100 ranks increased from 14% with the geometric scoring to 54% with the combination of all scoring functions. Especially for the enzyme-inhibitor complexes the results of the ranking are excellent. For half of these complexes a near-native structure can be predicted within the first 10 proposed structures and for more than 86% of all enzyme-inhibitor complexes within the first 50 predicted structures. Conclusion We were able to develop a combination of different scoring schemes which considers a series of previously described and some new scoring criteria yielding a remarkable improvement of prediction quality.

  9. Issues in automatic combination of cloud services

    NARCIS (Netherlands)

    Nguyen, D.K.; Lelli, F.; Papazoglou, M.; van den Heuvel, W.J.A.M.

    2012-01-01

    Current cloud service description languages envision the ability to automatically combine cloud service offerings across multiple abstraction layers, i.e. software, platform, and infrastructure service offerings, to achieve a common shared business goal. However, only little effort has been spent in

  10. Successive combination jet algorithm for hadron collisions

    International Nuclear Information System (INIS)

    Ellis, S.D.; Soper, D.E.

    1993-01-01

    Jet finding algorithms, as they are used in e + e- and hadron collisions, are reviewed and compared. It is suggested that a successive combination style algorithm, similar to that used in e + e- physics, might be useful also in hadron collisions, where cone style algorithms have been used previously

  11. Combining the power of searching and querying

    NARCIS (Netherlands)

    Cohen, S.; Kanza, Y.; Kogan, Y.A.; Nutt, W.; Sagiv, Y.; Serebrenik, A.; Etzion, O.; Scheuermann, P.

    2000-01-01

    EquiX is a search language for XML that combines the power of querying with the simplicity of searching. Requirements for search languages are discussed and it is shown that EquiX meets the necessary criteria. Both a graphical abstract syntax and a formal concrete syntax are presented for EquiX

  12. Epidemiological association between osteoporosis and combined ...

    African Journals Online (AJOL)

    ... higher dietary calcium intake was negatively associated with osteoporosis. Conclusions: Based on these findings, it can be concluded that the combined lifetime use of both snuff and cigarettes may increase the odds of developing osteoporosis among women who are 40 years and older. Key words: Cigarette, nicotine, ...

  13. [Combined physiotherapy of chronic infectious prostatitis].

    Science.gov (United States)

    Churakov, A A; Popkov, V M; Zemskov, S P; Glybochko, P V; Bliumberg, B I

    2007-01-01

    Our experience with therapy of 259 outpatients with chronic infectious prostatitis (CIP) aged 16-55 years has demonstrated that combined treatment of CIP with rectal digital massage of the prostate, electrophoresis of chimotripsin solution with dimexide and local magnetotherapy (Intramag unit) significantly raises treatment efficacy, shortens treatment, prevents complications.

  14. Combined solar collector and energy storage system

    Science.gov (United States)

    Jensen, R. N. (Inventor)

    1980-01-01

    A combined solar energy collector, fluid chiller and energy storage system is disclosed. A movable interior insulated panel in a storage tank is positionable flush against the storage tank wall to insulate the tank for energy storage. The movable interior insulated panel is alternately positionable to form a solar collector or fluid chiller through which the fluid flows by natural circulation.

  15. Combined testing of castings having rough surface

    International Nuclear Information System (INIS)

    Polyakov, Yu.O.; Zav'yalkin, F.M.; Moskvin, V.N.

    1988-01-01

    Mathematical models of a flaw detector for complex testing of castings, containing radiometric and pneumatic converters, are developed and investigated. The efficiency of compensation of casting thickness fluctuation effect on the results of testing in combined information processing obtained by various methods is estimated

  16. 38 CFR 21.4233 - Combination.

    Science.gov (United States)

    2010-07-01

    ...) VOCATIONAL REHABILITATION AND EDUCATION Administration of Educational Assistance Programs Programs of... combination of institutional agricultural courses and concurrent agricultural employment (see § 21.4264). A... of the training bears to full time as defined in § 21.4270(c) of this part. The institutional portion...

  17. Effects of combination of ethylenediaminetetraacetic acid and ...

    African Journals Online (AJOL)

    This experiment was conducted to evaluate the combined effects of ethylene diamine tetraacetic acid (EDTA) and microbial phytase (MP) on the serum concentration and digestibility of some minerals in broiler chicks. This experiment was conducted using 360 Ross-308 male broiler chicks in a completely randomized ...

  18. Combination therapies in oral squamous cell carcinomas

    International Nuclear Information System (INIS)

    Krishnamurthi, S.; Shanta, V.

    1982-01-01

    The clinical trials are reported involving combined radiotherapy and chemotherapy in oral squamous cell carcinomas. Bleomycin was the only drug that potentiated radiation response in buccal squamous cell carcinomas. The response of the primary tumors was consistent, predictable and reproducible. The following drugs or chemicals were used: synkavit, methotrexate, metronidazole, bleomycin, pepleomycin, and hyperbaric oxygen. The results and their comparison is given in tables

  19. Apparatus for combining oxygen and hydrogen

    International Nuclear Information System (INIS)

    Betz, E.C.

    1977-01-01

    An apparatus is described for catalytically combining hydrogen and oxygen which includes two concentric catalyst chambers arranged so that the outer chamber surrounds the inner chamber and the gas stream passes radially through the outer catalyst chamber. 10 claims, 2 figures

  20. Combined optical/digital security devices

    Science.gov (United States)

    Girnyk, Vladimir I.; Tverdokhleb, Igor V.; Ivanovsky, Andrey A.

    2000-04-01

    Modern holographic security devices used as emblems against counterfeiting are being more difficult as they should oppress criminal world. 2D, 3D, 3D rainbow holograms or simple diffraction structures protecting documents can not be acceptable against illegal copying of important documents, banknotes or valuable products. Recent developments in technology of Optical variable devices permit world leaders to create more advanced security elements: Kinegrams, Exelgrams, Pixelgrams, Kineforms. These products are used for protecting the most confidential documents and banknotes, but now even their security level can not be enough and besides their automatic identification is vulnerable to factors of instability. We elaborate new visual security devices based on the usage of expensive and advanced technology of combined optical/digital security devices. The technology unites digital and analogue methods of synthesis and recording of visual security devices. The analogue methods include techniques of optical holography - different combinations of 2D/3D, 3D, 2D/3D + 3D structures. Basing on them the design with elements of 3D graphics including security elements and hidden machine- readable images are implemented. The digital methods provide synthesis of optical variable devices including special security elements, computer generated holograms and Kineforms. Using them we create determined and quasi-random machine-readable images. Recordings are carried out using the combined optical and electronic submicrometer technology elaborated by Optronics, Ltd. The results obtained show effectiveness of the combined technology permitting to increase the security level essentially that should increase tamper and counterfeit resistance during many years.

  1. Multiswitching combination–combination synchronization of chaotic ...

    Indian Academy of Sciences (India)

    2017-02-09

    Feb 9, 2017 ... restricted to single drive–response system model. It is therefore interesting to ask whether these studies ... this scheme, a universal controller is designed to realize synchronization between a combination of two ... literature [33]. In view of the above discussions, in this paper, we present a new multiswitching ...

  2. Estimation of structural reliability under combined loads

    International Nuclear Information System (INIS)

    Shinozuka, M.; Kako, T.; Hwang, H.; Brown, P.; Reich, M.

    1983-01-01

    For the overall safety evaluation of seismic category I structures subjected to various load combinations, a quantitative measure of the structural reliability in terms of a limit state probability can be conveniently used. For this purpose, the reliability analysis method for dynamic loads, which has recently been developed by the authors, was combined with the existing standard reliability analysis procedure for static and quasi-static loads. The significant parameters that enter into the analysis are: the rate at which each load (dead load, accidental internal pressure, earthquake, etc.) will occur, its duration and intensity. All these parameters are basically random variables for most of the loads to be considered. For dynamic loads, the overall intensity is usually characterized not only by their dynamic components but also by their static components. The structure considered in the present paper is a reinforced concrete containment structure subjected to various static and dynamic loads such as dead loads, accidental pressure, earthquake acceleration, etc. Computations are performed to evaluate the limit state probabilities under each load combination separately and also under all possible combinations of such loads

  3. Combined radiotherapy-chemotherapy in clinical practice

    International Nuclear Information System (INIS)

    Horwich, A.

    1989-01-01

    This paper investigates the combination of radiotherapy and chemotherapy performed over the last 15 years. The improvement of the therapeutic ratio of anti- cancer effect to normal tissue toxicity and its requirement of a thorough understanding of the biological effects of each modality and of how these effects may interact is presented. Early studies and conclusions are examined

  4. Combined matrices in special classes of matrices

    Czech Academy of Sciences Publication Activity Database

    Fiedler, Miroslav; Markham, T. L.

    2011-01-01

    Roč. 435, č. 8 (2011), s. 1945-1955 ISSN 0024-3795 Institutional research plan: CEZ:AV0Z10300504 Keywords : combined matrix * Hadamard product * positive definite matrix * M-matrix * totally positive matrix * oscillatory matrix * Cauchy matrix Subject RIV: BA - General Mathematics Impact factor: 0.974, year: 2011

  5. Combination of radiation injuries: pathogenesis, clinic, therapy

    International Nuclear Information System (INIS)

    Tsyba, A.F.; Farshatova, M.N.

    1993-01-01

    Modern notions on combined radiation injuries (CRI) are presented. Characteristic of injurious factors of nuclear explosion and common regularities of the CRI origination is given. The data on the CRI clinical peculiarities, diagnostics and treatment, principles of medical assistance for the injured on the stages of medical evacuation and recommendations on rehabilitation are presented

  6. Combination of ATLAS Higgs Boson measurements

    CERN Document Server

    Monticelli, Fernando; The ATLAS collaboration

    2018-01-01

    The results obtained from the different decay channels are combined to study the properties of the Higgs boson mass, production and decay, and test the SM theoretical precision with increased accuracy, using about 36 fb^{-1} of p-p collisions data collected at 13 TeV.

  7. Towards combined global monthly gravity field solutions

    Science.gov (United States)

    Jaeggi, Adrian; Meyer, Ulrich; Beutler, Gerhard; Weigelt, Matthias; van Dam, Tonie; Mayer-Gürr, Torsten; Flury, Jakob; Flechtner, Frank; Dahle, Christoph; Lemoine, Jean-Michel; Bruinsma, Sean

    2014-05-01

    Currently, official GRACE Science Data System (SDS) monthly gravity field solutions are generated independently by the Centre for Space Research (CSR) and the German Research Centre for Geosciences (GFZ). Additional GRACE SDS monthly fields are provided by the Jet Propulsion Laboratory (JPL) for validation and outside the SDS by a number of other institutions worldwide. Although the adopted background models and processing standards have been harmonized more and more by the various processing centers during the past years, notable differences still exist and the users are more or less left alone with a decision which model to choose for their individual applications. This procedure seriously limits the accessibility of these valuable data. Combinations are well established in the area of other space geodetic techniques, such as the Global Navigation Satellite Systems (GNSS), Satellite Laser Ranging (SLR), and Very Long Baseline Interferometry (VLBI). Regularly comparing and combining space-geodetic products has tremendously increased the usefulness of the products in a wide range of disciplines and scientific applications. Therefore, we propose in a first step to mutually compare the large variety of available monthly GRACE gravity field solutions, e.g., by assessing the signal content over selected regions, by estimating the noise over the oceans, and by performing significance tests. We make the attempt to assign different solution characteristics to different processing strategies in order to identify subsets of solutions, which are based on similar processing strategies. Using these subsets we will in a second step explore ways to generate combined solutions, e.g., based on a weighted average of the individual solutions using empirical weights derived from pair-wise comparisons. We will also assess the quality of such a combined solution and discuss the potential benefits for the GRACE and GRACE-FO user community, but also address minimum processing

  8. PHARMACOECONOMIC ANALYSIS OF ANTIHYPERTENSIVE DRUG COMBINATIONS USE

    Directory of Open Access Journals (Sweden)

    E. I. Tarlovskaya

    2015-09-01

    Full Text Available Aim. To pursue pharmacoeconomic analysis of two drug combinations of ACE inhibitor (enalapril and diuretic.Material and methods. Patients with arterial hypertension degree 2 and diabetes mellitus type 2 without ischemic heart disease (n=56 were included into the study. Blood pressure (BP dynamics and cost/effectiveness ratio were evaluated.Results. In group A (fixed combination of original enalapril/hydrochlorothiazide 61% of patients achieved target BP level with initial dose, and the rest 39% of patients – with double dose. In group B (non-fixed combination of generic enalapril/indapamide 60% of patients achieved the target BP with initial dose of drugs, 33% - with double dose of ACE inhibitor, and 7% - with additional amlodipine administration. In patients of group A systolic BP (SBP reduction was 45.82±1.23 mm Hg by the 12th week vs. 40.0±0.81 mm Hg in patients of group B; diastolic BP (DBP reduction was 22.47±1.05 mm Hg and 18.76±0.70 mm Hg, respectively, by the 12th week of treatment. In the first month of treatment costs of target BP achievement was 298.62 rubles per patient in group A, and 299.50 rubles – in group B; by the 12th week of treatment – 629.45 and 631.22 rubles, respectively. Costs of SBP and DBP reduction by 1 mm Hg during 12 weeks of therapy were 13 and 27 rubles per patient, respectively, in group A, and 16 and 34 rubles per patient, respectively, in group B.Conclusion. The original fixed combination (enalapril+hydrochlorothiazide proved to be more clinically effective and more cost effective in the treatment of hypertensive patients in comparison with the non-fixed combination of generic drugs (enalapril+indapamide.

  9. Combination N-Way Power Divider/Combiner and Noninvasive Reflected Power Detection

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — An N-way RF/microwave power divider/combiner utilizes one input and N outputs, or conversely N inputs and one output to divide (or combine) RF/microwave power while...

  10. Further development of mathematical description for combined toxicity: A case study of lead–fluoride combination

    Directory of Open Access Journals (Sweden)

    Vladimir G. Panov

    2015-01-01

    Full Text Available In this article, we check and develop further some postulates of the theory and mathematical modeling of combined toxic effect that we proposed earlier [1]. To this end, we have analyzed the results of an experiment on rats exposed during 6 weeks to repeated intraperitoneal injections of lead acetate, sodium fluoride or both. The development of intoxication was estimated quantitatively with 54 functional, biochemical and morphometric indices. For mathematical description of the effect that lead and fluorine doses produced alone or in combination, we used a response surface regression model containing linear and cross terms (hyperbolic paraboloid. It is shown that the combination of lead and fluoride features the same 10 types of combined effect that we found previously for the lead and cadmium combination. Special attention is given to indices on which lead and fluorine produce an opposite effect.

  11. Tumor Specific Detection of an Optically Targeted Antibody Combined with a Quencher-conjugated Neutravidin “Quencher-Chaser”: A Dual “Quench and Chase” Strategy to Improve Target to Non-target Ratios for Molecular Imaging of Cancer

    Science.gov (United States)

    Ogawa, Mikako; Kosaka, Nobuyuki; Choyke, Peter L; Kobayashi, Hisataka

    2009-01-01

    and could not bind to nAv-QSY21. In conclusion, the proposed “quench-and-chase” system combines two strategies, fluorescent quenching and avidin chasing to improve target TBR and reduce non target TBR which should result in both improved tumor sensitivity and specificity. PMID:19072537

  12. Combined spinal intramedullary arteriovenous malformation and lipomyelomeningocele

    Energy Technology Data Exchange (ETDEWEB)

    Weon, Y.C.; Roh, H.G.; Byun, H.S. [Samsung Medical Center, Sungkyunkwan University School of Medicine, Department of Radiology, Seoul (Korea); Chung, J.I. [Medimoa Hospital, Department of Radiology, Seoul (Korea); Eoh, W. [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea)

    2005-10-01

    Combined spinal arteriovenous malformation and lipomyelomeningocele are extremely rare. We present a rare combined case of a lipomyelomeningocele with an intramedullary arteriovenous malformation (AVM) occurred at the L3-L4 level in a 30-year-old man who suffered from low back pain radiating to the lower extremities, dysuria, and frequency for 5 years. The MR studies showed an intradural mass with high-signal intensity on both T1-weighted and T2-weighted images, intermingled with multiple signal-void structures. The mass extended extradurally toward a subcutaneously forming fatty mass on the patient's back. Spinal angiography showed an AVM supplied by the radiculopial branches of the lumbar arteries and drained by tortuous, dilated, perimedullary veins. Endovascular embolization and surgical resection were performed. (orig.)

  13. Consensus paper: combining transcranial stimulation with neuroimaging

    DEFF Research Database (Denmark)

    Siebner, Hartwig R; Bergmann, Til O; Bestmann, Sven

    2009-01-01

    neuroimaging (online approach), TMS can be used to test how focal cortex stimulation acutely modifies the activity and connectivity in the stimulated neuronal circuits. TMS and neuroimaging can also be separated in time (offline approach). A conditioning session of repetitive TMS (rTMS) may be used to induce...... information obtained by neuroimaging can be used to define the optimal site and time point of stimulation in a subsequent experiment in which TMS is used to probe the functional contribution of the stimulated area to a specific task. In this review, we first address some general methodologic issues that need......In the last decade, combined transcranial magnetic stimulation (TMS)-neuroimaging studies have greatly stimulated research in the field of TMS and neuroimaging. Here, we review how TMS can be combined with various neuroimaging techniques to investigate human brain function. When applied during...

  14. RESTAURANT RESERVATION MANAGEMENT CONSIDERING TABLE COMBINATION

    Directory of Open Access Journals (Sweden)

    Qing Miao

    Full Text Available ABSTRACT This paper presents a case study of table reservation practice for restaurant business within Walt Disney World. A unique feature here is to consider table combination to capture revenue potentials from different party sizes and at different time periods. For example, a party of large size can be served by combining two or more small tables. A mixed integer programming (MIP model is developed to make the reservation recommendation. We propose a rolling horizon reservation policy such that the value of a particular table is periodically evaluated and updated. This is a typical revenue management method in the airlines and other industries, the essence of which is to compare the future expected revenue with a currently offered price. Using historical data, numerical test shows a significant revenue improvement potential from our proposed model.

  15. Camera System MTF: combining optic with detector

    Science.gov (United States)

    Andersen, Torben B.; Granger, Zachary A.

    2017-08-01

    MTF is one of the most common metrics used to quantify the resolving power of an optical component. Extensive literature is dedicated to describing methods to calculate the Modulation Transfer Function (MTF) for stand-alone optical components such as a camera lens or telescope, and some literature addresses approaches to determine an MTF for combination of an optic with a detector. The formulations pertaining to a combined electro-optical system MTF are mostly based on theory, and assumptions that detector MTF is described only by the pixel pitch which does not account for wavelength dependencies. When working with real hardware, detectors are often characterized by testing MTF at discrete wavelengths. This paper presents a method to simplify the calculation of a polychromatic system MTF when it is permissible to consider the detector MTF to be independent of wavelength.

  16. Estimation of combined sewer overflow discharge

    DEFF Research Database (Denmark)

    Ahm, Malte; Thorndahl, Søren Liedtke; Nielsen, Jesper Ellerbæk

    2016-01-01

    Combined sewer overflow (CSO) structures are constructed to effectively discharge excess water during heavy rainfall, to protect the urban drainage system from hydraulic overload. Consequently, most CSO structures are not constructed according to basic hydraulic principles for ideal measurement......-balance in combined sewer catchments. A closed mass-balance is an advantage for calibration of all urban drainage models based on mass-balance principles. This study presents three different software sensor concepts based on local water level sensors, which can be used to estimate CSO discharge volumes from hydraulic...... complex CSO structures. The three concepts was tested and verified under real practical conditions. All three concepts were accurate when compared to electromagnetic flow measurements....

  17. Object attributes combine additively in visual search.

    Science.gov (United States)

    Pramod, R T; Arun, S P

    2016-01-01

    We perceive objects as containing a variety of attributes: local features, relations between features, internal details, and global properties. But we know little about how they combine. Here, we report a remarkably simple additive rule that governs how these diverse object attributes combine in vision. The perceived dissimilarity between two objects was accurately explained as a sum of (a) spatially tuned local contour-matching processes modulated by part decomposition; (b) differences in internal details, such as texture; (c) differences in emergent attributes, such as symmetry; and (d) differences in global properties, such as orientation or overall configuration of parts. Our results elucidate an enduring question in object vision by showing that the whole object is not a sum of its parts but a sum of its many attributes.

  18. Sensitivity of a combined gravitational antenna

    International Nuclear Information System (INIS)

    Kulagin, V.V.; Rudenko, V.N.

    1986-01-01

    A modification of a combined optico-acoustic gravitational antenna: a long-base laser interferometer, where free masses are changed by Weber resonators, is suggested. The combined gravitational antenna can possess sensitivity h min ∼ 10 -18 without deep cooling of Weber resonators and h min ∼ 10 -19 at helium temperaure of the resonators. This antenna has the following new quantities: presence of three independent responses, that permits to a considerable extent to exclude non-gravitational effects; presence of responses of two separated Weber resonators, that permits to register the wave character of gravitational perturbation by measuring phase shift between relaxation ''tails''. It means that one may with certainty register the wave structure of gravitational radiation for perturbation of metrics h, exceeding the threshold sensitivity of the known detectors by an order

  19. Lymphocytic nucleolar index in the combined application

    Energy Technology Data Exchange (ETDEWEB)

    Kilyovska, M.; Nechev, Kh.; Vankova, P.; Tsvetkov, P.; Shopova, V. (Meditsinski Fakultet, Pleven (Bulgaria). Katedra Mediko-Sanitarna Zashtita)

    1982-01-01

    Sex mature male rats were irradiated with 5,25 and 50 rad from X-ray source. One group of irradiated animals was treated intraperitoneally with 10 mCi/animal Ce/sup 144/ or 0.04 mCi/g Sr/sup 89/. The second group was treated only with radionuclide. The nucleolar index (NI) of the lymphocytes in a blood smear was studied on the 1st, 3rd, 8th and 30th day after application. It was found that X-irradiation increased the value of NI after the 15th day, the effect being independent on the dose rates. Ce/sup 144/, applied alone in combination with external irradiation, also causes an increase of NI. Combined application of Sr/sup 89/ and external irradiation leads after one month to a decrease of NI. The results are discussed in connection with radionuclide kinetics and dose distribution.

  20. PANSAID-PAracetamol and NSAID in combination

    DEFF Research Database (Denmark)

    Thybo, Kasper Højgaard; Jakobsen, Janus Christian; Hägi-Pedersen, Daniel

    2017-01-01

    in patients having total hip arthroplastic surgery. Patients, caregivers, physicians, investigators, and statisticians are blinded to the intervention. The two co-primary outcomes are 24-h consumption of morphine and proportion of patients with one or more serious adverse events within 90 days after surgery....... Secondary outcomes are pain scores during mobilisation and at rest at 6 and 24 h postoperatively, and the proportion of patients with one or more adverse events within 24 h postoperatively. DISCUSSION: PANSAID will provide a large trial with low risk of bias regarding benefits and harms of the combination......BACKGROUND: Effective postoperative pain management is essential for the rehabilitation of the surgical patient. The PANSAID trial evaluates the analgesic effects and safety of the combination of paracetamol and ibuprofen. This paper describes in detail the statistical analysis plan for the primary...

  1. Combining resummed Higgs predictions across jet bins

    Energy Technology Data Exchange (ETDEWEB)

    Boughezal, Radja [Argonne National Laboratory, IL (United States). High Energy Physics Division; Liu, Xiaohui; Petriello, Frank [Argonne National Laboratory, IL (United States). High Energy Physics Division; Northwestern Univ., Evanston, IL (United States). Dept. of Physics and Astronomy; Tackmann, Frank J. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Walsh, Jonathan R. [California Univ., Berkeley, CA (United States). Ernest Orlando Lawrence Berkeley Laboratory; California Univ., Berkeley, CA (United States). Center for Theoretical Physics

    2013-12-15

    Experimental analyses often use jet binning to distinguish between different kinematic regimes and separate contributions from background processes. To accurately model theoretical uncertainties in these measurements, a consistent description of the jet bins is required. We present a complete framework for the combination of resummed results for production processes in different exclusive jet bins, focusing on Higgs production in gluon fusion as an example. We extend the resummation of the H+1-jet cross section into the challenging low transverse momentum region, lowering the uncertainties considerably. We provide combined predictions with resummation for cross sections in the H+0-jet and H+1-jet bins, and give an improved theory covariance matrix for use in experimental studies. We estimate that the relevant theoretical uncertainties on the signal strength in the H{yields}WW{sup *} analysis are reduced by nearly a factor of 2 compared to the current value.

  2. Combination stem cell therapy for heart failure

    Directory of Open Access Journals (Sweden)

    Ichim Thomas E

    2010-04-01

    Full Text Available Abstract Patients with congestive heart failure (CHF that are not eligible for transplantation have limited therapeutic options. Stem cell therapy such as autologous bone marrow, mobilized peripheral blood, or purified cells thereof has been used clinically since 2001. To date over 1000 patients have received cellular therapy as part of randomized trials, with the general consensus being that a moderate but statistically significant benefit occurs. Therefore, one of the important next steps in the field is optimization. In this paper we discuss three ways to approach this issue: a increasing stem cell migration to the heart; b augmenting stem cell activity; and c combining existing stem cell therapies to recapitulate a "therapeutic niche". We conclude by describing a case report of a heart failure patient treated with a combination stem cell protocol in an attempt to augment beneficial aspects of cord blood CD34 cells and mesenchymal-like stem cells.

  3. Organosilicon fluid for cooling coal combine motors

    Energy Technology Data Exchange (ETDEWEB)

    Donets, I K; Dmitrenko, Yu N; Kovalev, Ye B; Sukhanov, V V; Tsingarelli, Ye P

    1983-01-01

    Results are presented of toxicological evaluation of the polymer organosilicon fluid FM-5.6AP which should be used as the cooling agent of the electric motors of coal combines. It was established that fluid FM-5.6AP belongs to the low-toxic substances that do not have skinresorptive, skin-damaging and cumulative effect, do not have a significant influence on phagocytosis of the coal dust, in depositing in the lungs and elimination. During experimental industrial tests of the motor using the fluid FM-5.6AP, no toxic effect of it on the body was revealed. The possibility is shown of using organosilicon fluid FM-5.6AP for cooling electric motors of coal combines.

  4. [Combination therapy of chronic bacterial prostatitis].

    Science.gov (United States)

    Khryanin, A A; Reshetnikov, O V

    2016-08-01

    The article discusses the possible etiological factors in the development of chronic bacterial prostatitis. The authors presented a comparative long-term analysis of morbidity from non-viral sexually transmitted infections (STIs) in Russia. Against the background of general decline in STIs incidence, a significant percentage of them is made up by urogenital trichomoniasis. The findings substantiated the advantages of combination therapy (ornidazole and ofloxacin) for bacterial urinary tract infections.

  5. Combined interferometric and polarimetric diagnostics for TEXTOR

    International Nuclear Information System (INIS)

    Soltwisch, H.

    1980-01-01

    A method for combining Faraday rotation measurements with a phase modulated HCN interferometer is described. Extended to a multichannel system this technique should allow to investigate the distributions of electron density and poloidal magnetic field in a Tokamak plasma. We discuss the principle of operation and appropriate evaluation of measured data with regard to TEXTOR parameters and give an estimate for the expected experimental accuracy. (orig./GG) 891 GG/orig.- 892 KN

  6. Rocket Based Combined Cycle (RBCC) Engine

    Science.gov (United States)

    2004-01-01

    Pictured is an artist's concept of the Rocket Based Combined Cycle (RBCC) launch. The RBCC's overall objective is to provide a technology test bed to investigate critical technologies associated with opperational usage of these engines. The program will focus on near term technologies that can be leveraged to ultimately serve as the near term basis for Two Stage to Orbit (TSTO) air breathing propulsions systems and ultimately a Single Stage To Orbit (SSTO) air breathing propulsion system.

  7. Multi combined Adlerian supervision in Counseling

    OpenAIRE

    Gungor, Abdi

    2017-01-01

    For counselor professional and counselor education, supervision is an important process, in which more experienced professional helps and guides less experienced professional. To provide an effective and beneficial supervision, various therapy, development, or process based approaches and models have been developed. In addition, different eclectic models integrating more than one model have been developed. In this paper, as a supervision model, multi combined Adlerian supervision model is pro...

  8. Combining data in non-destructive testing

    International Nuclear Information System (INIS)

    Lavayssiere, B.

    1994-03-01

    Non-destructive testing of some components requires quite often the use of several methods such as X-ray, ultrasonics, Eddy Currents. But the efficiency of a NDT method is highly dependent on the fact that the detectability of flaws in a specimen relies on the choice of the best method. Moreover a lot of inspection issues could benefit from the use of more than one test method, as each NDT method has its own physical properties and technological limits. Some questions still remain: how to combine data, at what level and for what functionality. Simple monomethod processes are well-known now. They include techniques like reconstruction which belongs to the so-called ill-posed problems in the field of mathematics. For NDT data processing, it has the ability to estimate real data from distorted ones coming from a probe. But, up to now there has been very few approaches for computer aided combination of results from different advanced techniques. This report presents the various mathematical fields involved towards that goal (statistical decision theory which allows the use of multiple hypothesis, non-linear decision theory for its capability to classify and to discriminate, graph theory to find the optimal path in an hypothesis graph and also fuzzy logic, multiple resolution analysis, artificial intelligence,...) and which combinations of methods are useful. Some images will illustrate this topic in which EDF is involved, and will explain what are the major goals of this work. Combining is not only an improvement of 3D visualisation which would allow to display simultaneously CAD or NDT data for example, but it consists in exploiting multisensor data collected via a variety of sophisticated techniques and presenting this information to the operator without overloading the operator/system capacities in order to reduce the uncertainty and to resolve the ambiguity inherent to mono method inspection. (author). 7 figs., 35 refs

  9. ACCOUNTING FOR CONTINGENT CONSIDERATIONS IN BUSINESS COMBINATIONS

    OpenAIRE

    Gurgen KALASHYAN

    2017-01-01

    According to IFRS 3 Business Combinations contingent considerations must be included in the total consideration given for the acquired entity along with cash, other assets, ordinary or preference equity instruments, options, warrants. The contingent consideration is the determined amount which acquiring entity has to pay to acquired entity provided, that certain conditions will be fulfilled in the future. In case the provisions are not satisfied, we will get the situation when the amount of c...

  10. Screening for severe combined immunodeficiency in neonates

    OpenAIRE

    Kelly, Brian T; Tam, Jonathan S; Verbsky, James W; Routes, John M

    2013-01-01

    Brian T Kelly,1 Jonathan S Tam,1 James W Verbsky,1,2 John M Routes1,2 1Department of Pediatrics, 2Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI, USA Abstract: Severe combined immunodeficiency (SCID) is a rare disease that severely affects the cellular and humoral immune systems. Patients with SCID present with recurrent or severe infections and often with chronic diarrhea and failure to thrive. The disease is uniformly fatal, making early diag...

  11. Combined analog-to-digital converter

    International Nuclear Information System (INIS)

    Zhukov, A.V.; Rzhendinskaya, S.N.

    1983-01-01

    A 10-bit analog-to-digital converter (ADC) designed for operating in spectrometers with time-dependent filters is described. The ADC operation is based on combining the parallel reading and sequential counting methods. At maximum conversion time of 12 μs, timing series frequency of 25 MHz and foUr reference levels the differential nonlinearity withoUt statistical smoothing (maximum relative channel width deviation from average value) is not more than 4%

  12. Suction caissons subjected to monotonic combined loading

    OpenAIRE

    Penzes, P.; Jensen, M.R.; Zania, Varvara

    2016-01-01

    Suction caissons are being increasingly used as offshore foundation solutions in shallow and intermediate water depths. The convenient installation method through the application of suction has rendered this type of foundation as an attractive alternative to the more traditional monopile foundation for offshore wind turbines. The combined loading imposed typically to a suction caisson has led to the estimation of their bearing capacity by means of 3D failure envelopes. This study aims to anal...

  13. Combined confinement system applied to tokamaks

    International Nuclear Information System (INIS)

    Ohkawa, Tihiro

    1986-01-01

    From particle orbit point of view, a tokamak is a combined confinement configuration where a closed toroidal volume is surrounded by an open confinement system like a magnetic mirror. By eliminating a cold halo plasma, the energy loss from the plasma becomes convective. The H-mode in diverted tokamaks is an example. Because of the favorable scaling of the energy confinement time with temperature, the performance of the tokamak may be significantly improved by taking advantage of this effect. (author)

  14. Coherent beam combination via microparticle plasma modes

    International Nuclear Information System (INIS)

    Rogovin, D.; Shen, T.P.

    1988-01-01

    Recently, there have been interesting observations and calculations on phase conjugation via degenerate four-wave mixing in gold colloids. The generation of phase conjugate radiation in these media arises from and reflects the creation of static index grating imposed on the electronic wave functions within the microparticles. These encouraging findings motivate us to consider the possibility of generating moving index gratings in these media with possible applications to coherent beam combination

  15. Combination of irradiation and thermal processing

    International Nuclear Information System (INIS)

    Hozova, B.; Sorman, L.

    1991-01-01

    Recently, the technology and methods of food preservation have searched for ever better and less destructive methods and procedures which prolong the shelf-life of the primary products so that they do not undergo degradation processes. New non-traditional methods of preservation, as well as the procedures based on scientifically controlled combination of two or more preservation methods give increasingly higher chances for the improvement of the quality of canned products. Such combinations should reduce the intensity of the adverse effects of separately applied preservation methods. The aim is to achieve synergic or additive effects of the decisive factors, which would ensure microbiological adequacy and storage stability of canned foods, including maximum retention of their nutritional and sensory characteristics. If the published scientific papers dealing with non-traditional methods of food preservation and application of combination of preservation methods are evaluated, it can be seen that there is no work which provides an analysis of this problem. The use of ionizing radiation can reduce the number of microorganisms on foods and doses of up to 10 kGy are not considered to present any toxicological risks. However results have not been satisfactory mainly due to the interaction of ionizing radiation with the components of the irradiated foods. It is desirable to reduce the side effects of radiosterilizing doses by reducing the dose and using another method to complete the processing. Special attention is paid particularly to the use of combinations of heat and irradiation, since this is suitable mainly for the preservation of meat products but can also be applied to vegetables and other products. (author)

  16. Cost allocation. Combined heat and power production

    International Nuclear Information System (INIS)

    Sidzikauskas, V.

    2002-01-01

    The benefits of Combined Heat and Power (CHP) generation are discussed. The include improvement in energy intensity of 1% by 2010, 85-90% efficiency versus 40-50% of condensation power and others. Share of CHP electricity production in ERRA countries is presented.Solutions for a development CHP cost allocation are considered. Conclusion are presented for CHP production cost allocation. (R.P.)

  17. On Coding Non-Contiguous Letter Combinations

    Directory of Open Access Journals (Sweden)

    Frédéric eDandurand

    2011-06-01

    Full Text Available Starting from the hypothesis that printed word identification initially involves the parallel mapping of visual features onto location-specific letter identities, we analyze the type of information that would be involved in optimally mapping this location-specific orthographic code onto a location-invariant lexical code. We assume that some intermediate level of coding exists between individual letters and whole words, and that this involves the representation of letter combinations. We then investigate the nature of this intermediate level of coding given the constraints of optimality. This intermediate level of coding is expected to compress data while retaining as much information as possible about word identity. Information conveyed by letters is a function of how much they constrain word identity and how visible they are. Optimization of this coding is a combination of minimizing resources (using the most compact representations and maximizing information. We show that in a large proportion of cases, non-contiguous letter sequences contain more information than contiguous sequences, while at the same time requiring less precise coding. Moreover, we found that the best predictor of human performance in orthographic priming experiments was within-word ranking of conditional probabilities, rather than average conditional probabilities. We conclude that from an optimality perspective, readers learn to select certain contiguous and non-contiguous letter combinations as information that provides the best cue to word identity.

  18. Regulatory requirements for marketing fixed dose combinations

    Directory of Open Access Journals (Sweden)

    B G Jayasheel

    2010-01-01

    Full Text Available The development of fixed-dose combinations (FDCs is becoming increasingly important from a public health perspective. FDCs have advantages when there is an identifiable patient population for whom treatment with a particular combination of actives in a fixed ratio is safe and effective and when all of the actives contribute to the overall therapeutic effect. Such combinations of drugs are particularly useful in the management of chronic diseases. In addition, there can be real clinical benefits in the form of increased efficacy and/or a reduced incidence of adverse effects. Additional advantages of FDCs are potentially lower costs of manufacturing compared to the costs of producing separate products administered concurrently, simpler logistics of distribution and reduced development of resistance in the case of antimicrobials. Above all, FDC therapy reduces pill burden and improves medication compliance. Although, FDCs seem to be ideal under certain pre-defined circumstances, if a dosing adjustment is warranted, there may not be an FDC available in the most appropriate strength for the patient and if an adverse drug reaction occurs from using an FDC, it may be difficult to identify the active ingredient responsible for causing the reaction. Appendix VI of Schedule Y (Drugs & Cosmetics Rules 1945, India states the requirements for marketing approval of various types of FDCs. The same is further elaborated in this article to provide a detailed guidance including the clinical trial requirements. However, the heterogeneity of the therapeutic field makes it difficult to develop a standard guidance document.

  19. Combined effects of radiation and trauma

    Science.gov (United States)

    Messerschmidt, Otfried

    Injuries, caused by both whole-body irradiation and wounds or burns, have been relatively little studied. Possibly because many investigators think that these injuries are just modified radiation-induced diseases for which the same treatment principles are valid. Other authors had the impression that, for instance, the radiation burn trauma is a new kind of disease which differs significantly from either radiation syndrome alone or from burn disease. There are many experimental data on animals which suggest that the pathology of combined injuries differs significantly from that of radiation-induced disease or of thermal or mechanical traumas. Wounds or burns which, in general, do not cause septicaemia could become entrance ports for bacteria when animals are exposed to whole-body irradiation. Thrombocytopenia is the reason for hemorrhages in wounds. The susceptibility to shock is increased considerably in combined injuries and the formation of callus in the bone fractures is significantly delayed. The healing of wounds and burns in the initial phase of the radiation syndrome does not always differ from healing in the non-irradiated organism. However, a few days or weeks later very serious wound infections and hemorrhages can occur. The additional injuries almost always worsen the development and prognosis of radiation-induced disease. The recommended treatment for combined injuries will differ in many respects from the treatment of wounds and burns or the radiation syndrome.

  20. Reports from the Combined Performance Working Groups

    CERN Multimedia

    S. Haywood

    The main goal of the Combined Performance Groups is to study the detector performance for physics, as well as to monitor the effect of changes to the detector layout and the evolution of the software. The groups combine the expertise available in several different subdetectors. In addition, they are responsible for developing combined reconstruction algorithms and are involved in the calibration of energy scales and optimising resolutions. For the Workshop, the four groups made a real effort to compare the reconstruction in Athena (the "New" C++ software framework) and Atrecon (the "Old" software used for the TDR studies). b-tagging Working Group: Over the last few months, the description of the Inner Detector in the simulation has become more realistic, following the evolution of the detector design. This has caused the amount of material in the simulation to increase and the Pixel B-layer has been moved to a larger radius to allow for a wider beam-pipe. Nevertheless, the good performance of the b-tagging (...

  1. Genetic compatibility determines endophyte-grass combinations.

    Directory of Open Access Journals (Sweden)

    Kari Saikkonen

    Full Text Available Even highly mutually beneficial microbial-plant interactions, such as mycorrhizal- and rhizobial-plant exchanges, involve selfishness, cheating and power-struggles between the partners, which depending on prevailing selective pressures, lead to a continuum of interactions from antagonistic to mutualistic. Using manipulated grass-endophyte combinations in a five year common garden experiment, we show that grass genotypes and genetic mismatches constrain genetic combinations between the vertically (via host seeds transmitted endophytes and the out-crossing host, thereby reducing infections in established grass populations. Infections were lost in both grass tillers and seedlings in F(1 and F(2 generations, respectively. Experimental plants were collected as seeds from two different environments, i.e., meadows and nearby riverbanks. Endophyte-related benefits to the host included an increased number of inflorescences, but only in meadow plants and not until the last growing season of the experiment. Our results illustrate the importance of genetic host specificity and trans-generational maternal effects on the genetic structure of a host population, which act as destabilizing forces in endophyte-grass symbioses. We propose that (1 genetic mismatches may act as a buffering mechanism against highly competitive endophyte-grass genotype combinations threatening the biodiversity of grassland communities and (2 these mismatches should be acknowledged, particularly in breeding programmes aimed at harnessing systemic and heritable endophytes to improve the agriculturally valuable characteristics of cultivars.

  2. Unsupervised Retinal Vessel Segmentation Using Combined Filters.

    Directory of Open Access Journals (Sweden)

    Wendeson S Oliveira

    Full Text Available Image segmentation of retinal blood vessels is a process that can help to predict and diagnose cardiovascular related diseases, such as hypertension and diabetes, which are known to affect the retinal blood vessels' appearance. This work proposes an unsupervised method for the segmentation of retinal vessels images using a combined matched filter, Frangi's filter and Gabor Wavelet filter to enhance the images. The combination of these three filters in order to improve the segmentation is the main motivation of this work. We investigate two approaches to perform the filter combination: weighted mean and median ranking. Segmentation methods are tested after the vessel enhancement. Enhanced images with median ranking are segmented using a simple threshold criterion. Two segmentation procedures are applied when considering enhanced retinal images using the weighted mean approach. The first method is based on deformable models and the second uses fuzzy C-means for the image segmentation. The procedure is evaluated using two public image databases, Drive and Stare. The experimental results demonstrate that the proposed methods perform well for vessel segmentation in comparison with state-of-the-art methods.

  3. The 2004 ATLAS Combined Test Beam

    CERN Multimedia

    The ATLAS CTB Team, .

    2004-01-01

    In the year 2004, ATLAS has been involved in a huge combined test beam (CTB) effort in H8. A complete slice of the barrel detector and of the Muon End-cap has been tested, with the following clear goals: pre-commission the final elements and study the detector performance in a realistic combined data taking. Thanks to this experience, a lot of expertise in the operations has been acquired and much data (~ 4.6 TB of data, ~ 90 million events on castor) has been collected and is already under analysis. The CTB has been characterized by different phases with an incremental presence of sub-detectors modules and associated DAQ infrastructure, as well as incremental improvement of analysis tools for prompt data certification. The physics goals of the CTB have been defined in consultation with the physics coordinator, all the sub-detector representatives and the combined performance group representative. With all these indications, a detailed run plan day-by-day schedule was defined before the CTB start and was foll...

  4. Fixed Dose Combination for TB treatment

    Directory of Open Access Journals (Sweden)

    Tjandra Y. Aditama

    2003-06-01

    Full Text Available According to the World Health Organization, a third of the world’s population is infected with tuberculosis. The disease is responsible for nearly 2 million deaths each year and over 8 million were developing active diseases. Moreover, according to WHO (2000, tuberculosis deaths are estimated to increase to 35 million between 2000-2020. The majority of tuberculosis patients worldwide are still treated with single drugs, or with 2-drug fixed-dose combinations (FDCs. To improve tuberculosis treatment, 2- and 3-drug FDCs were recommended by the World Health Organization (WHO as part of the DOTS strategy. Since 1999 a 4-drug FDC was included on the WHO Model List of Essential Drugs. Today, FDCs are important tools to further improve the quality of care for people with TB, and accelerate DOTS expansion to reach the global TB control targets. Fixed dose combination TB drugs could simplifies both treatment and management of drug supply, and may prevent the emergence of drug resistance .Prevention of drug resistance is just one of the potential benefits of the use of FDCs. FDCs simplify administration of drugs by reducing the number of pills a patient takes each day and decreasing the risk of incorrect prescriptions. Most tuberculosis patients need only take 3–4 FDCs tablets per day during the intensive phase of treatment, instead of the 15–16 tablets per day that is common with single-drug formulations It is much simpler to explain to patients that they need to take four tablets of the same type and colour, rather than a mixture of tablets of different shapes, colours and sizes. Also, the chance of taking an incomplete combination of drugs is eliminated, since the four essential drugs are combined into one tablet. FDCs are also simpler for care-givers as they minimize the risk of confusion. Finally, drug procurement, in all its components (stock management, shipping, distribution, is simplified by FDCs. Adverse reactions to drugs are not more

  5. All-fiber 7x1 signal combiner for incoherent laser beam combining

    DEFF Research Database (Denmark)

    Noordegraaf, Danny; Maack, Martin D.; Skovgaard, Peter M. W.

    2011-01-01

    We demonstrate an all-fiber 7x1 signal combiner for incoherent laser beam combining. This is a potential key component for reaching several kW of stabile laser output power. The combiner couples the output from 7 single-mode (SM) fiber lasers into a single multi-mode (MM) fiber. The input signal ...... in device temperature is observed. At an intermediate power level of 600 W a beam parameter product (BPP) of 2.22 mm x mrad is measured, corresponding to an M2 value of 6.5. These values are approaching the theoretical limit dictated by brightness conservation....

  6. Combining disparate data for decision making

    Science.gov (United States)

    Gettings, M. E.

    2010-12-01

    Combining information of disparate types from multiple data or model sources is a fundamental task in decision making theory. Procedures for combining and utilizing quantitative data with uncertainties are well-developed in several approaches, but methods for including qualitative and semi-quantitative data are much less so. Possibility theory offers an approach to treating all three data types in an objective and repeatable way. In decision making, biases are frequently present in several forms, including those arising from data quality, data spatial and temporal distribution, and the analyst's knowledge and beliefs as to which data or models are most important. The latter bias is particularly evident in the case of qualitative data and there are numerous examples of analysts feeling that a qualitative dataset is more relevant than a quantified one. Possibility theory and fuzzy logic now provide fairly general rules for quantifying qualitative and semi-quantitative data in ways that are repeatable and minimally biased. Once a set of quantified data and/or model layers is obtained, there are several methods of combining them to obtain insight useful in decision making. These include: various combinations of layers using formal fuzzy logic (for example, layer A and (layer B or layer C) but not layer D); connecting the layers with varying influence links in a Fuzzy Cognitive Map; and using the set of layers for the universe of discourse for agent based model simulations. One example of logical combinations that have proven useful is the definition of possible habitat for valley fever fungus (Coccidioides sp.) using variables such as soil type, altitude, aspect, moisture and temperature. A second example is the delineation of the lithology and possible mineralization of several areas beneath basin fill in southern Arizona. A Fuzzy Cognitive Map example is the impacts of development and operation of a hypothetical mine in an area adjacent to a city. In this model

  7. IMPLICATION OF THE FIXED COMBINATIONS IN THE HYPERTENSION TREATMENT

    Directory of Open Access Journals (Sweden)

    Z. D. Kobalava

    2010-01-01

    Full Text Available The role of fixed combinations in the hypertension (HT treatment is discussed. Theoretical and practical aspects of combination therapy, principles of rational combination therapy are present. Current guidelines on the use of fixed dose combinations, including start antihypertensive therapy are analyzed. Classification of combinations, advantages and limitations of some of them implementation are also presented. Significance of beta-blocker bisoprolol and thiazide diuretic hydrochlorothiazide fixed combination (Lodoz is shown in HT treatment.

  8. Spectral beam combining of diode lasers with high efficiency

    DEFF Research Database (Denmark)

    Müller, André; Vijayakumar, Deepak; Jensen, Ole Bjarlin

    2012-01-01

    Based on spectral beam combining we obtain 16 W of output power, combining two 1063 nm DBR-tapered diode lasers. The spectral separation within the combined beam can be used for subsequent sum-frequency generation.......Based on spectral beam combining we obtain 16 W of output power, combining two 1063 nm DBR-tapered diode lasers. The spectral separation within the combined beam can be used for subsequent sum-frequency generation....

  9. VLBI TRF Combination Using GNSS Software

    Directory of Open Access Journals (Sweden)

    Younghee Kwak

    2013-12-01

    Full Text Available Space geodetic techniques can be used to obtain precise shape and rotation information of the Earth. To achieve this, the representative combination solution of each space geodetic technique has to be produced, and then those solutions need to be combined. In this study, the representative combination solution of very long baseline interferometry (VLBI, which is one of the space geodetic techniques, was produced, and the variations in the position coordinate of each station during 7 years were analyzed. Products from five analysis centers of the International VLBI Service for Geodesy and Astrometry (IVS were used as the input data, and Bernese 5.0, which is the global navigation satellite system (GNSS data processing software, was used. The analysis of the coordinate time series for the 43 VLBI stations indicated that the latitude component error was about 15.6 mm, the longitude component error was about 37.7 mm, and the height component error was about 30.9 mm, with respect to the reference frame, International Terrestrial Reference Frame 2008 (ITRF2008. The velocity vector of the 42 stations excluding the YEBES station showed a magnitude difference of 7.3 mm/yr (30.2% and a direction difference of 13.8° (3.8%, with respect to ITRF2008. Among these, the 10 stations in Europe showed a magnitude difference of 7.8 mm/yr (30.3% and a direction difference of 3.7° (1.0%, while the 14 stations in North America showed a magnitude difference of 2.7 mm/yr (15.8% and a direction difference of 10.3° (2.9%.

  10. Modeling of a combined cycle power plant

    International Nuclear Information System (INIS)

    Faridah Mohamad Idris

    2001-01-01

    The combined cycle power plant is a non-linear, closed loop system, which consists of high-pressure (HP) superheater, HP evaporator, HP economizer, low-pressure (LP) evaporator, HP drum, HP deaerator, condenser, HP and LP steam turbine and gas turbine. The two types of turbines in the plant for example the gas turbine and the HP and LP steam turbines operate concurrently to generate power to the plant. The exhaust gas which originate from the combustion chamber drives the gas turbine, after which it flows into the heat recovery steam generator (HRSG) to generate superheated steam to be used in driving the HP and LP steam turbines. In this thesis, the combined cycle power plant is modeled at component level using the physical method. Assuming that there is delay in transport, except for the gas turbine system, the mass and heat balances are applied on the components of the plant to derive the governing equations of the components. These time dependent equations, which are of first order differential types, are then solved for the mass and enthalpy of the components. The solutions were simulated using Matlab Simulink using measured plant data. Where necessary there is no plant data available, approximated data were used. The generalized regression neural networks are also used to generate extra sets of simulation data for the HRSG system. Comparisons of the simulation results with its corresponding plant data showed good agreements between the two and indicated that the models developed for the components could be used to represent the combined cycle power plant under study. (author)

  11. Preventive treatment of combined radiation injuries

    International Nuclear Information System (INIS)

    Boudagov, R.; Uljanova, L.; Makarov, G.

    1996-01-01

    The risk of sepsis development increases when thermal burns and other trauma occur in combination with exposure to radiation. Only surgical correction of the life-threatening state recommends within 48 hours after irradiation. All other arrangements have to carry out when hemopoiesis recovery will complete. However exposed patients with combined injuries (CI) die during the first two or three weeks mainly due to sepsis. Therefore prophylaxis and preventive therapy of infectious complications are need early. Actual difficulties in choice of valid treatment procedure for acute radiation syndrome (ARS) exhibit additional aggravation under CI. The available facts prove decreasing early therapy efficiency for rather high dose exposure and wound trauma occurrence. The own results showed that bacterial polysaccharide pyrogenal, glycopin (synthetic analogue of muramil-dipeptide), thymus preparations (thymozin, thymotropin, thymogen), tuftsin, heterologic human and bovine immunoglobulins did not modify the low values of 30-day survival under CI (irradiation + thermal burn). Single injection of prodigiozan, zymozan and some other yeast polysaccharides in 1 hr after CI resulted at moderate increasing of survival. The main purpose of this study, which bases upon our understanding of CI pathogenesis, was search more effective means for preventive treatment of combined radiation injuries. Two groups of remedies were under study. The first group included so called 'biological response modifiers' (BRM). These agents may increase host defences to infection, macrophage's activity and hemopoietic growth factor's secretion. The second group included antibiotics that should be directed against the potential gram-negative as well as gram-positive pathogens and simultaneously be useful for selective decontamination of gastrointestinal tract. (author)

  12. Binocular combination in abnormal binocular vision.

    Science.gov (United States)

    Ding, Jian; Klein, Stanley A; Levi, Dennis M

    2013-02-08

    We investigated suprathreshold binocular combination in humans with abnormal binocular visual experience early in life. In the first experiment we presented the two eyes with equal but opposite phase shifted sine waves and measured the perceived phase of the cyclopean sine wave. Normal observers have balanced vision between the two eyes when the two eyes' images have equal contrast (i.e., both eyes contribute equally to the perceived image and perceived phase = 0°). However, in observers with strabismus and/or amblyopia, balanced vision requires a higher contrast image in the nondominant eye (NDE) than the dominant eye (DE). This asymmetry between the two eyes is larger than predicted from the contrast sensitivities or monocular perceived contrast of the two eyes and is dependent on contrast and spatial frequency: more asymmetric with higher contrast and/or spatial frequency. Our results also revealed a surprising NDE-to-DE enhancement in some of our abnormal observers. This enhancement is not evident in normal vision because it is normally masked by interocular suppression. However, in these abnormal observers the NDE-to-DE suppression was weak or absent. In the second experiment, we used the identical stimuli to measure the perceived contrast of a cyclopean grating by matching the binocular combined contrast to a standard contrast presented to the DE. These measures provide strong constraints for model fitting. We found asymmetric interocular interactions in binocular contrast perception, which was dependent on both contrast and spatial frequency in the same way as in phase perception. By introducing asymmetric parameters to the modified Ding-Sperling model including interocular contrast gain enhancement, we succeeded in accounting for both binocular combined phase and contrast simultaneously. Adding binocular contrast gain control to the modified Ding-Sperling model enabled us to predict the results of dichoptic and binocular contrast discrimination experiments

  13. Combination TLD/TED dose assessment

    International Nuclear Information System (INIS)

    Parkhurst, M.A.

    1992-11-01

    During the early 1980s, an appraisal of dosimetry programs at US Department of Energy (DOE) facilities identified a significant weakness in dose assessment in fast neutron environments. Basing neutron dose equivalent on thermoluminescence dosimeters (TLDS) was not entirely satisfactory for environments that had not been well characterized. In most operational situations, the dosimeters overrespond to neutrons, and this overresponse could be further exaggerated with changes in the neutron quality factor (Q). Because TLDs are energy dependent with an excellent response to thermal and low-energy neutrons but a weak response to fast neutrons, calibrating the dosimetry system to account for mixed and moderated neutron energy fields is a difficult and seldom satisfactory exercise. To increase the detection of fast neutrons and help improve the accuracy of dose equivalent determinations, a combination dosimeter was developed using TLDs to detect thermal and low-energy neutrons and a track-etch detector (TED) to detect fast neutrons. By combining the albedo energy response function of the TLDs with the track detector elements, the dosimeter can nearly match the fluence-to-dose equivalent conversion curve. The polymer CR-39 has neutron detection characteristics superior to other materials tested. The CR-39 track detector is beta and gamma insensitive and does not require backscatter (albedo) from the body to detect the exposure. As part of DOE's Personnel Neutron and Upgrade Program, we have been developing a R-39 track detector over the past decade to address detection and measurement of fast neutrons. Using CR-39 TEDs in combination with TLDs will now allow us to detect the wide spectrum of occupational neutron energies and assign dose equivalents much more confidently

  14. The combination of electrospray and flow focusing

    Science.gov (United States)

    Gañán-Calvo, Alfonso M.; López-Herrera, José M.; Riesco-Chueca, Pascual

    2006-11-01

    An ultra-fine liquid atomization procedure combining the advantages of electrospray and flow focusing is presented. Both techniques are known to produce strikingly small and steady liquid micro-jets issuing from menisci held by capillary forces. Such menisci take the form of a cusp-like drop attached to the feeding tube (flow focusing: FF) or a Taylor cone (electrospray: ES). The issuing micro-jets are forced or ‘sucked’ from the parent meniscus either by pressure or electrohydrodynamic forces. Subsequent capillary breakup of the jet leads to fine sprays of remarkable quality. Here we describe the joint effect of pressurization and electrification in a flow focusing device, and the subsequent coupling of both ES and FF phenomena. For any given liquid and flow rate, the combined procedure gives rise to significantly smaller droplet sizes than observed in any of the source techniques. The co-flowing gas stream removes space charges; in addition, the perforated plate facing the feed tube provides an electric barrier, shielding the jet-meniscus or ‘production’ area from the spray or ‘product’ area. As a result, space charges and electrified droplets are removed from the production area, thus avoiding the ambient electric saturation which becomes a limiting factor in ES-spraying: a significantly enhanced spraying stability ensues, with a much wider operation range than FF or ES. Other unexpected outcomes from the combination are also shown. A theoretical model is developed to predict the emitted droplet size: a first integral of the momentum equation yielding a generalized Bernoulli equation, and an explicit approximation for the jet diameter and droplet size, accurate within a broad parametrical band.

  15. Combining cluster number counts and galaxy clustering

    Energy Technology Data Exchange (ETDEWEB)

    Lacasa, Fabien; Rosenfeld, Rogerio, E-mail: fabien@ift.unesp.br, E-mail: rosenfel@ift.unesp.br [ICTP South American Institute for Fundamental Research, Instituto de Física Teórica, Universidade Estadual Paulista, São Paulo (Brazil)

    2016-08-01

    The abundance of clusters and the clustering of galaxies are two of the important cosmological probes for current and future large scale surveys of galaxies, such as the Dark Energy Survey. In order to combine them one has to account for the fact that they are not independent quantities, since they probe the same density field. It is important to develop a good understanding of their correlation in order to extract parameter constraints. We present a detailed modelling of the joint covariance matrix between cluster number counts and the galaxy angular power spectrum. We employ the framework of the halo model complemented by a Halo Occupation Distribution model (HOD). We demonstrate the importance of accounting for non-Gaussianity to produce accurate covariance predictions. Indeed, we show that the non-Gaussian covariance becomes dominant at small scales, low redshifts or high cluster masses. We discuss in particular the case of the super-sample covariance (SSC), including the effects of galaxy shot-noise, halo second order bias and non-local bias. We demonstrate that the SSC obeys mathematical inequalities and positivity. Using the joint covariance matrix and a Fisher matrix methodology, we examine the prospects of combining these two probes to constrain cosmological and HOD parameters. We find that the combination indeed results in noticeably better constraints, with improvements of order 20% on cosmological parameters compared to the best single probe, and even greater improvement on HOD parameters, with reduction of error bars by a factor 1.4-4.8. This happens in particular because the cross-covariance introduces a synergy between the probes on small scales. We conclude that accounting for non-Gaussian effects is required for the joint analysis of these observables in galaxy surveys.

  16. Combined Pulmonary Fibrosis and Emphysema Syndrome

    Science.gov (United States)

    Rounds, Sharon I. S.

    2012-01-01

    There is increasing clinical, radiologic, and pathologic recognition of the coexistence of emphysema and pulmonary fibrosis in the same patient, resulting in a clinical syndrome known as combined pulmonary fibrosis and emphysema (CPFE) that is characterized by dyspnea, upper-lobe emphysema, lower-lobe fibrosis, and abnormalities of gas exchange. This syndrome frequently is complicated by pulmonary hypertension, acute lung injury, and lung cancer. The CPFE syndrome typically occurs in male smokers, and the mortality associated with this condition, especially if pulmonary hypertension is present, is significant. In this review, we explore the current state of the literature and discuss etiologic factors and clinical characteristics of the CPFE syndrome. PMID:22215830

  17. Combined constraints on holographic bosonic technicolor

    International Nuclear Information System (INIS)

    Carone, Christopher D.; Primulando, Reinard

    2010-01-01

    We consider a model of strong electroweak symmetry breaking in which the expectation value of an additional, possibly composite, scalar field is responsible for the generation of fermion masses. The dynamics of the strongly coupled sector is defined and studied via its holographic dual, and does not correspond to a simple, scaled-up version of QCD. We consider the bounds from perturbative unitarity, the S parameter, and the mass of the Higgs-like scalar. We show that the combination of these constraints leaves a relatively limited region of parameter space viable, and suggests the qualitative features of the model that might be probed at the LHC.

  18. Biopiles and biofilters combined for soil cleanup

    International Nuclear Information System (INIS)

    Lei, J.; Sansregret, J.L.; Cyr, B.

    1994-01-01

    Bioremediation of hydrocarbon-contaminated soils can be completed using a combination of biopile and biofiltration technologies. Target contaminants, such as gasoline, jet fuel, diesel fuel and other petroleum-derived products are removed from the soil by biodegradation and volatilization in the biopile. Air emissions from the biopile containing volatile hydrocarbons are treated subsequently in a biofilter, where the pollutants are degraded and mineralized by heterotrophic aerobic microorganisms. In the biopile process, contaminated soil is excavated and stockpiled in a treatment area. Remediation of the soil relies on microbial degradation and volatilization of hydrocarbons under controlled treatment conditions

  19. Combination of behavioural and cognitive techniques

    Directory of Open Access Journals (Sweden)

    Leonida Rotvejn Pajič

    2001-03-01

    Full Text Available The cognitive - behavioral approach in the treatment of behavioral disorders, emotional disorders and learning difficulties is not limited to a single theoretical principle or technique, but integrates different techniques. The variants techniques are derived from theoretical and empirical findings in different domains of developmental psychology (self-control, social cognition, memory, metacognitive and attritional processes. The aim of the article is to present some basic cognitive and behavioral techniques that are individually adapted during therapy and mutually complete each other. A practical case of combining techniques is presented.

  20. Combining accounting approaches to practice valuation.

    Science.gov (United States)

    Schwartzben, D; Finkler, S A

    1998-06-01

    Healthcare organizations that wish to acquire physician or ambulatory care practices can choose from a variety of practice valuation approaches. Basic accounting methods assess the value of a physician practice on the basis of a historical, balance-sheet description of tangible assets. Yet these methods alone are inadequate to determine the true financial value of a practice. By using a combination of accounting approaches to practice valuation that consider factors such as fair market value, opportunity cost, and discounted cash flow over a defined time period, organizations can more accurately assess a practice's actual value.

  1. Anticancer Efficacy of Polyphenols and Their Combinations

    Directory of Open Access Journals (Sweden)

    Aleksandra Niedzwiecki

    2016-09-01

    Full Text Available Polyphenols, found abundantly in plants, display many anticarcinogenic properties including their inhibitory effects on cancer cell proliferation, tumor growth, angiogenesis, metastasis, and inflammation as well as inducing apoptosis. In addition, they can modulate immune system response and protect normal cells against free radicals damage. Most investigations on anticancer mechanisms of polyphenols were conducted with individual compounds. However, several studies, including ours, have indicated that anti-cancer efficacy and scope of action can be further enhanced by combining them synergistically with chemically similar or different compounds. While most studies investigated the anti-cancer effects of combinations of two or three compounds, we used more comprehensive mixtures of specific polyphenols and mixtures of polyphenols with vitamins, amino acids and other micronutrients. The mixture containing quercetin, curcumin, green tea, cruciferex, and resveratrol (PB demonstrated significant inhibition of the growth of Fanconi anemia head and neck squamous cell carcinoma and dose-dependent inhibition of cell proliferation, matrix metalloproteinase (MMP-2 and -9 secretion, cell migration and invasion through Matrigel. PB was found effective in inhibition of fibrosarcoma HT-1080 and melanoma A2058 cell proliferation, MMP-2 and -9 expression, invasion through Matrigel and inducing apoptosis, important parameters for cancer prevention. A combination of polyphenols (quercetin and green tea extract with vitamin C, amino acids and other micronutrients (EPQ demonstrated significant suppression of ovarian cancer ES-2 xenograft tumor growth and suppression of ovarian tumor growth and lung metastasis from IP injection of ovarian cancer A-2780 cells. The EPQ mixture without quercetin (NM also has shown potent anticancer activity in vivo and in vitro in a few dozen cancer cell lines by inhibiting tumor growth and metastasis, MMP-2 and -9 secretion, invasion

  2. Combining or Separating Forward and Reverse Logistics

    DEFF Research Database (Denmark)

    Herbert-Hansen, Zaza Nadja Lee; Larsen, Samuel; Nielsen, Anders

    2018-01-01

    Purpose – While forward logistics handles and manages the flow of goods downstream in the supply chain from suppliers to customers, reverse logistics (RL) manages the flow of returned goods upstream. A firm can combine reverse logistics with forward logistics, keep the flows separated, or choose......-research addresses intra-RL issues while the relationship between forward and reverse logistics is under-researched. This paper contributes to RL-theory by identifying the contextual factors that determine the most advantageous relationship between forward and reverse logistics, and proposes a novel decision making...

  3. A Combined Preconditioning Strategy for Nonsymmetric Systems

    KAUST Repository

    Ayuso Dios, Blanca

    2014-01-01

    We present and analyze a class of nonsymmetric preconditioners within a normal (weighted least-squares) matrix form for use in GMRES to solve nonsymmetric matrix problems that typically arise in finite element discretizations. An example of the additive Schwarz method applied to nonsymmetric but definite matrices is presented for which the abstract assumptions are verified. A variable preconditioner, combining the original nonsymmetric one and a weighted least-squares version of it, is shown to be convergent and provides a viable strategy for using nonsymmetric preconditioners in practice. Numerical results are included to assess the theory and the performance of the proposed preconditioners.

  4. Targeting IAP proteins in combination with radiotherapy

    International Nuclear Information System (INIS)

    Fulda, Simone

    2015-01-01

    The efficacy of radiotherapy critically depends on the activation of intrinsic cell death programs in cancer cells. This implies that evasion of cell death, a hallmark of human cancers, can contribute to radioresistance. Therefore, novel strategies to reactivate cell death programs in cancer cells are required in order to overcome resistance to radiotherapy. Since Inhibitor of Apoptosis (IAP) proteins are expressed at high levels in multiple cancers and block cell death induction at a central point, therapeutic targeting of IAP proteins represents a promising approach to potentiate the efficacy of radiotherapy. The current review discusses the concept of targeting IAP proteins in combination with radiotherapy

  5. Combined cycle plant controls retrofit case history

    International Nuclear Information System (INIS)

    Tenney, D.; Pieszchala, T.

    1991-01-01

    The Comanche Power Station, Public Service of Oklahoma's combined cycle generating facility, underwent a controls and operator panel retrofit at the end of 1988. The plant consists of two gas turbines, two heat recovery boilers and a steam turbine along with three generators. This paper examines the extent to which the original goals and specifications were met. Costs, operating principles and modifications since the original installation are discussed. Operating procedures are compared with the original system. The future of the plant is discussed and the impact on the power system grid is analyzed

  6. COMBINED SURGERY OF SPREAD THYROID CANCER

    Directory of Open Access Journals (Sweden)

    V. Zh. Brzhezovsky

    2014-01-01

    Full Text Available Results of treating of 99 patients with differentiated thyroid cancer spreading beyond the capsule of the organ were analysed. In most cases with spreading the tumor to the tracheal rings performing of organ-preserving operations (from “window-like” tracheal resections to circular tracheal resection with intertracheal anastomosis is possible. Choosing of type of operation to be performed depends on localisation and spread of tumor invasion of trachea, pharynx and esophagus. Using of combined operations in patients with locally-spread thyroid cancer allows to achieve long and stable remission in most of the cases.

  7. Trial of radiation therapy combined with hyperthermia

    Energy Technology Data Exchange (ETDEWEB)

    Takegawa, Y; Fujiwara, K; Oe, J; Nagase, M; Akiyama, H [Tokushima Univ. (Japan). School of Medicine

    1978-08-01

    Nine patients were treated by the combination therapy of external irradiation and hyperthermia, 5 patients with metastatic lesions; two breast cancer, one lung cancer, one malignant melanoma, one vulva cancer, 1 patient with recurrent lesion of skin cancer and 3 patients with bladder cancer. All patients were treated by heating locally (42/sup 0/C, 30 min) followed by external irradiation with 4,000 - 5,000 rad over 4 to 5 weeks. No local recurrence was found in 4 of 9 patients.

  8. Strongyloides Hyperinfection Syndrome Combined with Cytomegalovirus Infection

    Directory of Open Access Journals (Sweden)

    Fatehi Elnour Elzein

    2016-01-01

    Full Text Available The mortality in Strongyloides hyperinfection syndrome (SHS is alarmingly high. This is particularly common in bone marrow, renal, and other solid organ transplant (SOT patients, where figures may reach up to 50–85%. Immunosuppressives, principally corticosteroids, are the primary triggering factor. In general, the clinical features of Strongyloides stercoralis hyperinfection are nonspecific; therefore, a high index of suspicion is required for early diagnosis and starting appropriate therapy. Although recurrent Gram-negative sepsis and meningitis have been previously reported, the combination of both cytomegalovirus (CMV and strongyloidiasis had rarely been associated. We here describe a patient who survived SHS with recurrent Escherichia coli (E. coli urosepsis and CMV infection.

  9. A Combined Preconditioning Strategy for Nonsymmetric Systems

    Energy Technology Data Exchange (ETDEWEB)

    de Dios, B. Ayuso [Univ. of Bologna (Italy). Dept. of Mathematics; King Abdullah Univ. of Science and Technology, Thuwal (Saudi Arabia); Barker, A. T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Vassilevski, P. S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2014-11-04

    Here, we present and analyze a class of nonsymmetric preconditioners within a normal (weighted least-squares) matrix form for use in GMRES to solve nonsymmetric matrix problems that typically arise in finite element discretizations. An example of the additive Schwarz method applied to nonsymmetric but definite matrices is presented for which the abstract assumptions are verified. Variable preconditioner, which combines the original nonsymmetric one and a weighted least-squares version of it, and it is shown to be convergent and provides a viable strategy for using nonsymmetric preconditioners in practice. Numerical results are included to assess the theory and the performance of the proposed preconditioners.

  10. High performance integrated solar combined cycles with minimum modifications to the combined cycle power plant design

    International Nuclear Information System (INIS)

    Manente, Giovanni

    2016-01-01

    Highlights: • Off-design model of a 390 MW_e three pressure combined cycle developed and validated. • The off-design model is used to evaluate different hybridization schemes with solar. • Power boosting and fuel saving with different design modifications are considered. • Maximum solar share of total electricity is only 1% with the existing equipment. • The maximum incremental solar radiation-to-electrical efficiency approaches 29%. - Abstract: The integration of solar energy into natural gas combined cycles has been successfully demonstrated in several integrated solar combined cycles since the beginning of this decade in many countries. There are many motivations that drive investments on integrated solar combined cycles which are primarily the repowering of existing power plants, the compliance with more severe environmental laws on emissions and the mitigation of risks associated with large solar projects. Integrated solar combined cycles are usually developed as brownfield facilities by retrofitting existing natural gas combined cycles and keeping the existing equipment to minimize costs. In this work a detailed off-design model of a 390 MW_e three pressure level natural gas combined cycle is built to evaluate different integration schemes of solar energy which either keep the equipment of the combined cycle unchanged or include new equipment (steam turbine, heat recovery steam generator). Both power boosting and fuel saving operation strategies are analyzed in the search for the highest annual efficiency and solar share. Results show that the maximum incremental power output from solar at design solar irradiance is limited to 19 MW_e without modifications to the existing equipment. Higher values are attainable only including a larger steam turbine. High solar radiation-to-electrical efficiencies in the range 24–29% can be achieved in the integrated solar combined cycle depending on solar share and extension of tube banks in the heat recovery

  11. Combining radiotherapy and immunotherapy: A revived partnership

    International Nuclear Information System (INIS)

    Demaria, Sandra; Bhardwaj, Nina; McBride, William H.; Formenti, Silvia C.

    2005-01-01

    Ionizing radiation therapy (RT) is an important local modality for the treatment of cancer. The current rationale for its use is based largely on the ability of RT to kill the cancer cells by a direct cytotoxic effect. Nevertheless, considerable evidence indicates that RT effects extend beyond the mere elimination of the more radiosensitive fraction of cancer cells present within a tumor at the time of radiation exposure. For instance, a large body of evidence is accumulating on the ability of RT to modify the tumor microenvironment and generate inflammation. This might have far-reaching consequences regarding the response of a patient to treatment, especially if radiation-induced tumor cell kill were to translate into the generation of effective antitumor immunity. Although much remains to be learned about how radiation can impact tumor immunogenicity, data from preclinical studies provide the proof of principle that different immunotherapeutic strategies can be combined with RT to enhance antitumor effects. Conversely, RT could be a useful tool to combine with immunotherapy. This article will briefly summarize what is known about the impact of RT on tumor immunity, including tumor-associated antigens, antigen-presenting cells, and effector mechanisms. In addition, the experimental evidence supporting the contention that RT can be used as a tool to induce antitumor immunity is discussed, and a new approach to radioimmunotherapy of cancer is proposed

  12. Checkpoint blockade in combination with cancer vaccines.

    Science.gov (United States)

    Morse, Michael A; Lyerly, H Kim

    2015-12-16

    Checkpoint blockade, prevention of inhibitory signaling that limits activation or function of tumor antigen-specific T cells responses, is revolutionizing the treatment of many poor prognosis malignancies. Indeed monoclonal antibodies that modulate signaling through the inhibitory molecules CTLA-4 and PD-1 are now clinically available; however, many tumors, demonstrate minimal response suggesting the need for combinations with other therapeutic strategies. Because an inadequate frequency of activated tumor antigen-specific T cells in the tumor environment, the so-called non-inflamed phenotype, is observed in some malignancies, other rationale partners are modalities that lead to enhanced T cell activation (vaccines, cytokines, toll-like receptor agonists, and other anticancer therapies such as chemo-, radio- or targeted therapies that lead to release of antigen from tumors). This review will focus on preclinical and clinical data supporting the use of cancer vaccines with anti-CTLA-4 and anti-PD-1/PD-L1 antibodies. Preliminary preclinical data demonstrate enhanced antitumor activity although the results in human studies are less clear. Broader combinations of multiple immune modulators are now under study. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Irradiation in combined treatments and food safety

    International Nuclear Information System (INIS)

    Lacroix Monique; Dussault Dominic; Turgis Melanie; Salmieri Stephane; Perlette Takala; Vu Dang Khanh; Ayari Samia

    2013-01-01

    Irradiation combined with other processes can contribute to insuring food safety to consumers and controlling severe losses during transportation and commercialisation. We have demonstrated that using in synergy with other treatments; a lower dose could be used to eliminate pathogenic bacteria and permit a better protection of the sensorial quality and to prolong the shelf life of foods. Results indicated that some bacteria are more sensitive to irradiation under modified atmosphere (MAP) and the presence of active compound can increase the bacterial radiosensitivity by more than 4 times under air and by more than 10 times under MAP. Mild heat treatment or addition of natural antimicrobial compounds before irradiation treatment has also permitted an increase of Bacillus cereus radiosensitization. An increase of the bacterial radiosensitization of 1.5 and 1.56 was respectively observed. The effectiveness of the use of edible coating containing natural antimicrobial compounds, modified atmosphere packaging (MAP) or mild treatment before irradiation treatment was demonstrated in order to inactivate Listeria monocytogenes, Salmonella typhimurium, Escherichia coli and Bacillus cereus growth or B. cereus spore germination, to increase the bacterial sensitivity to irradiation, to reduce the water loss and to extend the shelf life of the food when stored at 4 deg C. Also, the use of edible coating previously crosslinked by irradiation have permitted a better control of the active compounds release. Studies of combined treatments were used in ready to eat vegetables, fruits and meat products. (author)

  14. Combining rhinoplasty with septal perforation repair.

    Science.gov (United States)

    Foda, Hossam M T; Magdy, Emad A

    2006-11-01

    A combined septal perforation repair and rhinoplasty was performed in 80 patients presenting with septal perforations (size 1 to 5 cm) and external nasal deformities. The external rhinoplasty approach was used for all cases and the perforation was repaired using bilateral intranasal mucosal advancement flaps with a connective tissue interposition graft in between. Complete closure of the perforation was achieved in 90% of perforations of size up to 3.5 cm and in only 70% of perforations that were larger than 3.5 cm. Cosmetically, 95% were very satisfied with their aesthetic result. The external rhinoplasty approach proved to be very helpful in the process of septal perforation repair especially in large and posteriorly located perforations and in cases where the caudal septal cartilage was previously resected. Our results show that septal perforation repair can be safely combined with rhinoplasty and that some of the routine rhinoplasty maneuvers, such as medial osteotomies and dorsal lowering, could even facilitate the process of septal perforation repair.

  15. Reproductive cloning combined with genetic modification.

    Science.gov (United States)

    Strong, C

    2005-11-01

    Although there is widespread opposition to reproductive cloning, some have argued that its use by infertile couples to have genetically related children would be ethically justifiable. Others have suggested that lesbian or gay couples might wish to use cloning to have genetically related children. Most of the main objections to human reproductive cloning are based on the child's lack of unique nuclear DNA. In the future, it may be possible safely to create children using cloning combined with genetic modifications, so that they have unique nuclear DNA. The genetic modifications could be aimed at giving such children genetic characteristics of both members of the couple concerned. Thus, cloning combined with genetic modification could be appealing to infertile, lesbian, or gay couples who seek genetically related children who have genetic characteristics of both members. In such scenarios, the various objections to human reproductive cloning that are based on the lack of genetic uniqueness would no longer be applicable. The author argues that it would be ethically justifiable for such couples to create children in this manner, assuming these techniques could be used safely.

  16. Single maximal versus combination punch kinematics.

    Science.gov (United States)

    Piorkowski, Barry A; Lees, Adrian; Barton, Gabor J

    2011-03-01

    The aim of this study was to determine the influence of punch type (Jab, Cross, Lead Hook and Reverse Hook) and punch modality (Single maximal, 'In-synch' and 'Out of synch' combination) on punch speed and delivery time. Ten competition-standard volunteers performed punches with markers placed on their anatomical landmarks for 3D motion capture with an eight-camera optoelectronic system. Speed and duration between key moments were computed. There were significant differences in contact speed between punch types (F(2,18,84.87) = 105.76, p = 0.001) with Lead and Reverse Hooks developing greater speed than Jab and Cross. There were significant differences in contact speed between punch modalities (F(2,64,102.87) = 23.52, p = 0.001) with the Single maximal (M+/- SD: 9.26 +/- 2.09 m/s) higher than 'Out of synch' (7.49 +/- 2.32 m/s), 'In-synch' left (8.01 +/- 2.35 m/s) or right lead (7.97 +/- 2.53 m/s). Delivery times were significantly lower for Jab and Cross than Hook. Times were significantly lower 'In-synch' than a Single maximal or 'Out of synch' combination mode. It is concluded that a defender may have more evasion-time than previously reported. This research could be of use to performers and coaches when considering training preparations.

  17. Combining Search Engines for Comparative Proteomics

    Science.gov (United States)

    Tabb, David

    2012-01-01

    Many proteomics laboratories have found spectral counting to be an ideal way to recognize biomarkers that differentiate cohorts of samples. This approach assumes that proteins that differ in quantity between samples will generate different numbers of identifiable tandem mass spectra. Increasingly, researchers are employing multiple search engines to maximize the identifications generated from data collections. This talk evaluates four strategies to combine information from multiple search engines in comparative proteomics. The “Count Sum” model pools the spectra across search engines. The “Vote Counting” model combines the judgments from each search engine by protein. Two other models employ parametric and non-parametric analyses of protein-specific p-values from different search engines. We evaluated the four strategies in two different data sets. The ABRF iPRG 2009 study generated five LC-MS/MS analyses of “red” E. coli and five analyses of “yellow” E. coli. NCI CPTAC Study 6 generated five concentrations of Sigma UPS1 spiked into a yeast background. All data were identified with X!Tandem, Sequest, MyriMatch, and TagRecon. For both sample types, “Vote Counting” appeared to manage the diverse identification sets most effectively, yielding heightened discrimination as more search engines were added.

  18. Combination antiretroviral therapy and cancer risk

    DEFF Research Database (Denmark)

    Borges, Álvaro H

    2017-01-01

    PURPOSE OF REVIEW: To review the newest research about the effects of combination antiretroviral therapy (cART) on cancer risk. RECENT FINDINGS: HIV+ persons are at increased risk of cancer. As this risk is higher for malignancies driven by viral and bacterial coinfections, classifying malignanci......ART initiation in reducing cancer risk, understand the relationship between long-term cART exposure and cancer incidence and assess whether adjuvant anti-inflammatory therapies can reduce cancer risk during treated HIV infection.......PURPOSE OF REVIEW: To review the newest research about the effects of combination antiretroviral therapy (cART) on cancer risk. RECENT FINDINGS: HIV+ persons are at increased risk of cancer. As this risk is higher for malignancies driven by viral and bacterial coinfections, classifying malignancies...... into infection-related and infection-unrelated has been an emerging trend. Cohorts have detected major reductions in the incidence of Kaposi sarcoma and non-Hodgkin lymphoma (NHL) following cART initiation among immunosuppressed HIV+ persons. However, recent randomized data indicate that cART reduces risk...

  19. Dextromethorphan and Quinidine Combination for Heroin Detoxification

    Science.gov (United States)

    Akerele, Evaristo; Bisaga, Adam; Sullivan, Maria A.; Garawi, Fatima; Comer, Sandra D.; Thomas, Anil A.; Nunes, Edward V.; Kleber, Herbert D.

    2015-01-01

    Dextromethorphan (DM) is a low-affinity, non-competitive NMDA receptor antagonist that has shown promise in pre-clinical and preliminary clinical studies for the reduction of opioid withdrawal symptoms, but when used at higher doses, it is associated with deleterious side effects attributed to its metabolite, dextrorphan. A clinical trial was therefore conducted to test the withdrawal-suppressant effect of a combination of dextromethorphan with quinidine (DM/Q). Quinidine inhibits the metabolism of dextromethorphan, reducing dextrorphan levels. Opioid-dependent patients were admitted to an inpatient unit, stabilized for three days on morphine (25 mg, sc, every six hours), and randomly assigned on day 2 to DM/Q (30 mg/30 mg, twice a day) (n = 22) or matching placebo (n = 9) prior to the discontinuation of morphine on day 4. Withdrawal symptoms, measured with the Modified Himmelsbach Opioid Withdrawal Scale (MHOWS), increased significantly on days 4 and 5 (Z = 3.70, p = .0002), and by day 6, 90% of the sample (28/31) had dropped out of the study. There were no differences between treatment groups on either outcome measure. The combination of dextromethorphan and quinidine appears ineffective as a primary treatment for opioid withdrawal. Future studies should examine dextromethorphan as an adjunct to other anti-withdrawal medications and focus more on the relationship between dextrorphan levels and withdrawal suppression. PMID:18463993

  20. ACCOUNTING FOR CONTINGENT CONSIDERATIONS IN BUSINESS COMBINATIONS

    Directory of Open Access Journals (Sweden)

    Gurgen KALASHYAN

    2017-07-01

    Full Text Available According to IFRS 3 Business Combinations contingent considerations must be included in the total consideration given for the acquired entity along with cash, other assets, ordinary or preference equity instruments, options, warrants. The contingent consideration is the determined amount which acquiring entity has to pay to acquired entity provided, that certain conditions will be fulfilled in the future. In case the provisions are not satisfied, we will get the situation when the amount of contingent consideration has been included in the total consideration given in the business combination, but in fact, the acquirer has not paid that amount. In its turn, the acquired entity will recognize the contingent consideration as a financial asset according to IFRS 9 Financial Instruments. In that case, it would be appropriately to recognize the contingent consideration as a contingent asset applying IAS 37. In the Article the author will explore the challenges of contingent consideration accounting and suggest the ways of solving the above mentioned problems.

  1. Combined experiment Phase 2 data characterization

    Energy Technology Data Exchange (ETDEWEB)

    Miller, M.S.; Shipley, D.E.; Young, T.S.; Robinson, M.C.; Luttges, M.W. [Colorado Univ., Boulder, CO (United States); Simms, D.A. [National Renewable Energy Lab., Golden, CO (United States)

    1995-11-01

    The National Renewable Energy Laboratory`s ``Combined Experiment`` has yielded a large quantity of experimental data on the operation of a downwind horizontal axis wind turbine under field conditions. To fully utilize this valuable resource and identify particular episodes of interest, a number of databases were created that characterize individual data events and rotational cycles over a wide range of parameters. Each of the 59 five-minute data episodes collected during Phase 11 of the Combined Experiment have been characterized by the mean, minimum, maximum, and standard deviation of all data channels, except the blade surface pressures. Inflow condition, aerodynamic force coefficient, and minimum leading edge pressure coefficient databases have also been established, characterizing each of nearly 21,000 blade rotational cycles. In addition, a number of tools have been developed for searching these databases for particular episodes of interest. Due to their extensive size, only a portion of the episode characterization databases are included in an appendix, and examples of the cycle characterization databases are given. The search tools are discussed and the FORTRAN or C code for each is included in appendices.

  2. Spatial aspects of combined modality radiotherapy

    International Nuclear Information System (INIS)

    Bodey, Rachel K.; Evans, Phil M.; Flux, Glenn D.

    2005-01-01

    Background and purpose: A combined modality radiotherapy (CMRT) incorporates both external beam radiotherapy (EBT) and targeted radionuclide therapy (TRT) components. The spatial aspects of this combination were explored by utilising intensity modulated radiotherapy (IMRT) to provide a non-uniform EBT dose distribution. Patients and methods: Three methods of prescribing the required non-uniform distribution of EBT dose are described, based on both physical and biological criteria according to the distribution of TRT uptake. The results and consequences of these prescriptions are explored by application to three examples of patient data. Results: The planning procedure adopted allowed IMRT plans to be produced that met the prescription requirements. However, when the treatment was planned as a CMRT, compared with the use of EBT alone, more satisfactory target doses could be achieved with lower doses to normal tissues. The effects of errors in EBT delivery and in the functional data were found to cause a non-uniform prescription to tend towards the uniform case. Conclusions: The methods and results are relevant for more general biological treatment planning, in which IMRT may be used to produce dose distributions prescribed according to tumour function. The effects of delivery and dose calculation errors can have a significant impact on how such treatments should be planned

  3. All-fiber 7x1 signal combiner for incoherent laser beam combining

    Science.gov (United States)

    Noordegraaf, D.; Maack, M. D.; Skovgaard, P. M. W.; Johansen, J.; Becker, F.; Belke, S.; Blomqvist, M.; Laegsgaard, J.

    2011-02-01

    We demonstrate an all-fiber 7x1 signal combiner for incoherent laser beam combining. This is a potential key component for reaching several kW of stabile laser output power. The combiner couples the output from 7 single-mode (SM) fiber lasers into a single multi-mode (MM) fiber. The input signal fibers have a core diameter of 17 μm and the output MM fiber has a core diameter of 100 μm. In a tapered section light gradually leaks out of the SM fibers and is captured by a surrounding fluorine-doped cladding. The combiner is tested up to 2.5 kW of combined output power and only a minor increase in device temperature is observed. At an intermediate power level of 600 W a beam parameter product (BPP) of 2.22 mm x mrad is measured, corresponding to an M2 value of 6.5. These values are approaching the theoretical limit dictated by brightness conservation.

  4. [Results of combined endotrabeculectomy and phacoemulsification surgery].

    Science.gov (United States)

    Novytskyy, I Ya; Novytskyy, M I

    2015-01-01

    to identify indications and evaluate the efficacy of combined endotrabeculectomy and phacoemulsification surgery. A total of 172 patients (193 eyes) with open-angle glaucoma and cataract were enrolled. Group 1 included 102 patients (118 eyes), who were considered surgical candidates due to decompensation of IOP, group 2--70 patients (75 eyes), in whom IOP control could only be achieved with a multidrug regimen (two or more ocular hypotensive medications). The mean preoperative IOP measured with Maklakov tonometer was 26.4 ± 1.8 mmHg in group 1 and 20.5 ± 1.7 mmHg in group 2. In 134 eyes the extent of retention of intraocular fluid was determined intraoperatively by provoking blood reflux into Schlemm's canal. In 6 out of 134 eyes (4.5%) Schlemm's canal was not at all filled with blood, which was considered a contraindication for endotrabeculectomy. Partial filling of Schlemm's canal with blood was observed in 26 out of 134 eyes (19.4%), complete--in 102 eyes (76.1%). All but 6 patients underwent endotrabeculectomy (ab interno trabecular excision with original forceps through the anterior chamber angle) combined with cataract phacoemulsification and intraocular lens implantation. In 11 out of 126 cases, insignificant bleeding occurred during sample acquisition. No other complications were registered. Six months after the surgery, IOP was reduced by the mean of 7.0 ± 0.6 mmHg (26.5% from the baseline) in group 1 and by 2.2 ± 0.2 mmHg (10.7% from the baseline) in group 2. The number of hypotensive medications by that time has been decreased from 2.3 ± 0.3 to 0.8 ± 0.2 in group 1 and from 1.6 ± 0.3 to 0.4 ± 0.1 in group 2. Combined endotrabeculectomy and phacoemulsification surgery is a pathogenically oriented procedure, which improves ocular hydrodynamics and has a significant hypotensive effect.

  5. Combining solid biomass combustion and stirling technology

    Energy Technology Data Exchange (ETDEWEB)

    Siemers, W.; Senkel, N. [CUTEC-Institut GmbH, Clausthal-Zellerfeld (Germany)], e-mail: werner.siemers@cutec.de

    2012-11-01

    Decentralised electricity production in combination with and based on biomass still finds some difficulties in real applications. One concept favoured in a recent project is the connection of a wood chip furmace with a Stirling engine. Because the direct exposure of the Stirling head causes numerous problems, the solution is sought in designing an indirect heat transfer system. The main challenge is the temperature level, which should be reached for high electrical efficiencies. Temperatures above 1000 deg C at the biomass combustion side are needed for an efficient heat transfer at some 850 deg C at the Stirling engine in theory. Measurements on both installations have been conducted and analyzed. After this, the design phase is started. However, no final choice on the design has been taken.

  6. Combined hydraulic and regenerative braking system

    Science.gov (United States)

    Venkataperumal, R.R.; Mericle, G.E.

    1979-08-09

    A combined hydraulic and regenerative braking system and method for an electric vehicle is disclosed. The braking system is responsive to the applied hydraulic pressure in a brake line to control the braking of the vehicle to be completely hydraulic up to a first level of brake line pressure, to be partially hydraulic at a constant braking force and partially regenerative at a linearly increasing braking force from the first level of applied brake line pressure to a higher second level of brake line pressure, to be partially hydraulic at a linearly increasing braking force and partially regenerative at a linearly decreasing braking force from the second level of applied line pressure to a third and higher level of applied line pressure, and to be completely hydraulic at a linearly increasing braking force from the third level to all higher applied levels of line pressure.

  7. Improved particle swarm optimization combined with chaos

    International Nuclear Information System (INIS)

    Liu Bo; Wang Ling; Jin Yihui; Tang Fang; Huang Dexian

    2005-01-01

    As a novel optimization technique, chaos has gained much attention and some applications during the past decade. For a given energy or cost function, by following chaotic ergodic orbits, a chaotic dynamic system may eventually reach the global optimum or its good approximation with high probability. To enhance the performance of particle swarm optimization (PSO), which is an evolutionary computation technique through individual improvement plus population cooperation and competition, hybrid particle swarm optimization algorithm is proposed by incorporating chaos. Firstly, adaptive inertia weight factor (AIWF) is introduced in PSO to efficiently balance the exploration and exploitation abilities. Secondly, PSO with AIWF and chaos are hybridized to form a chaotic PSO (CPSO), which reasonably combines the population-based evolutionary searching ability of PSO and chaotic searching behavior. Simulation results and comparisons with the standard PSO and several meta-heuristics show that the CPSO can effectively enhance the searching efficiency and greatly improve the searching quality

  8. LNG plant combined with power plant

    Energy Technology Data Exchange (ETDEWEB)

    Aoki, I; Kikkawa, Y [Chiyoda Chemical Engineering and Construction Co. Ltd., Tokyo (Japan)

    1997-06-01

    The LNG plant consumers a lot of power of natural gas cooling and liquefaction. In some LNG plant location, a rapid growth of electric power demand is expected due to the modernization of area and/or the country. The electric power demand will have a peak in day time and low consumption in night time, while the power demand of the LNG plant is almost constant due to its nature. Combining the LNG plant with power plant will contribute an improvement the thermal efficiency of the power plant by keeping higher average load of the power plant, which will lead to a reduction of electrical power generation cost. The sweet fuel gas to the power plant can be extracted from the LNG plant, which will be favorable from view point of clean air of the area. (Author). 5 figs.

  9. Theoretically palatable flavor combinations of astrophysical neutrinos

    International Nuclear Information System (INIS)

    Bustamante, Mauricio

    2015-07-01

    The flavor composition of high-energy astrophysical neutrinos can reveal the physics governing their production, propagation, and interaction. The IceCube Collaboration has published the first experimental determination of the ratio of the flux in each flavor to the total. We present, as a theoretical counterpart, new results for the allowed ranges of flavor ratios at Earth for arbitrary flavor ratios in the sources. Our results will allow IceCube to more quickly identify when their data imply standard physics, a general class of new physics with arbitrary (incoherent) combinations of mass eigenstates, or new physics that goes beyond that, e.g., with terms that dominate the Hamiltonian at high energy.

  10. Combining multiple decisions: applications to bioinformatics

    International Nuclear Information System (INIS)

    Yukinawa, N; Ishii, S; Takenouchi, T; Oba, S

    2008-01-01

    Multi-class classification is one of the fundamental tasks in bioinformatics and typically arises in cancer diagnosis studies by gene expression profiling. This article reviews two recent approaches to multi-class classification by combining multiple binary classifiers, which are formulated based on a unified framework of error-correcting output coding (ECOC). The first approach is to construct a multi-class classifier in which each binary classifier to be aggregated has a weight value to be optimally tuned based on the observed data. In the second approach, misclassification of each binary classifier is formulated as a bit inversion error with a probabilistic model by making an analogy to the context of information transmission theory. Experimental studies using various real-world datasets including cancer classification problems reveal that both of the new methods are superior or comparable to other multi-class classification methods

  11. Combining triggers in HEP data analysis

    International Nuclear Information System (INIS)

    Lendermann, Victor; Herbst, Michael; Krueger, Katja; Schultz-Coulon, Hans-Christian; Stamen, Rainer; Haller, Johannes

    2009-01-01

    Modern high-energy physics experiments collect data using dedicated complex multi-level trigger systems which perform an online selection of potentially interesting events. In general, this selection suffers from inefficiencies. A further loss of statistics occurs when the rate of accepted events is artificially scaled down in order to meet bandwidth constraints. An offline analysis of the recorded data must correct for the resulting losses in order to determine the original statistics of the analysed data sample. This is particularly challenging when data samples recorded by several triggers are combined. In this paper we present methods for the calculation of the offline corrections and study their statistical performance. Implications on building and operating trigger systems are discussed. (orig.)

  12. Combining triggers in HEP data analysis

    Energy Technology Data Exchange (ETDEWEB)

    Lendermann, Victor; Herbst, Michael; Krueger, Katja; Schultz-Coulon, Hans-Christian; Stamen, Rainer [Heidelberg Univ. (Germany). Kirchhoff-Institut fuer Physik; Haller, Johannes [Hamburg Univ. (Germany). Institut fuer Experimentalphysik

    2009-01-15

    Modern high-energy physics experiments collect data using dedicated complex multi-level trigger systems which perform an online selection of potentially interesting events. In general, this selection suffers from inefficiencies. A further loss of statistics occurs when the rate of accepted events is artificially scaled down in order to meet bandwidth constraints. An offline analysis of the recorded data must correct for the resulting losses in order to determine the original statistics of the analysed data sample. This is particularly challenging when data samples recorded by several triggers are combined. In this paper we present methods for the calculation of the offline corrections and study their statistical performance. Implications on building and operating trigger systems are discussed. (orig.)

  13. A combinational fast algorithm for image reconstruction

    International Nuclear Information System (INIS)

    Wu Zhongquan

    1987-01-01

    A combinational fast algorithm has been developed in order to increase the speed of reconstruction. First, an interpolation method based on B-spline functions is used in image reconstruction. Next, the influence of the boundary conditions assumed here on the interpolation of filtered projections and on the image reconstruction is discussed. It is shown that this boundary condition has almost no influence on the image in the central region of the image space, because the error of interpolation rapidly decreases by a factor of ten in shifting two pixels from the edge toward the center. In addition, a fast algorithm for computing the detecting angle has been used with the mentioned interpolation algorithm, and the cost for detecting angle computaton is reduced by a factor of two. The implementation results show that in the same subjective and objective fidelity, the computational cost for the interpolation using this algorithm is about one-twelfth of the conventional algorithm

  14. Combined heat and power in the City

    Energy Technology Data Exchange (ETDEWEB)

    Crafter, A. [Corporation of London (United Kingdom). Dept. of Technical Services

    2002-03-01

    This article reports on the development of a large-scale combined heat and power community energy scheme within the City of London. Supported by the Corporation of London and using its own buildings to provide the heating and cooling loads, the scheme has established a power plant close to Smithfield Meat Market and supplies district heating and chilled water for air conditioning to its own properties and some private customers in the nearby districts. Details are given of the power plant which is sited in a conservation area with limited access, the use of absorption chillers to produce the chilled water, the estimated amount of carbon dioxide emissions saved, and the financial benefits of the scheme.

  15. Sjogren's syndrome combined with MALT lymphoma

    International Nuclear Information System (INIS)

    Han, Won Jeong; Cha, Sang Yun; Kim, Eun Kyung

    2000-01-01

    Sjogren's syndrome is a chronic inflammatory disease that predominantly affects salivary, lacrimal, and other exocrine glands. We report a case of Sjogren's syndrome combined with MALT (mucose associated lymphoid tissue) lymphoma which occurred in the parotid gland. A 57-year-old female with the complaint of painful swelling and lymph node enlargement was referred to our department. Sialograms of both parotid glands showed globular collections of contrast material uniformly distributed throughout the parotid gland. Salivary scintigraphy showed decreased uptake of the parotid gland. CT scan showed larger, slightly more dense parotid gland than normal and honeycomb glandular appearance. Also, It showed discrete, slightly more enhanced round mass in the left parotid gland. Histopathological finding showed replacement of salivary gland parenchyma with dense small lymphocytic infiltration having the feature of epimyoepithelial islands. Kappa light chain restriction of interglandular plasma cell could be seen.

  16. Green ergonomics: combining sustainability and ergonomics.

    Science.gov (United States)

    Pilczuk, Davana; Barefield, Kevin

    2014-01-01

    When discussing ergonomics, the term 'sustainability' usually refers to the preservation of the human workforce. However, in 2010 Gulfstream Aerospace Corporation made a conscious effort to combine ergonomics and environmental sustainability in order to increase employee engagement for both programs. They introduced a companywide campaign called Green Ergo which is the idea of creating ergonomic solutions from scrap material found on site. This concept embraced the true meaning of 'green' and encouraged engineers and employees all across the company to design innovative green ergonomic solutions. The idea generated over 35 new ergo solutions, reduced waste production, and solved over 700 ergo problems for a fraction of the cost of newly purchased items. The demand for these items grew large enough that the company outsourced their manufacturing to a local non-profit. The Green Ergo campaign has changed the culture of the company and has increased the level of buy-in for both the ergonomics and sustainability programs.

  17. High Efficiency Ka-Band Spatial Combiner

    Directory of Open Access Journals (Sweden)

    D. Passi

    2014-12-01

    Full Text Available A Ka-Band, High Efficiency, Small Size Spatial Combiner (SPC is proposed in this paper, which uses an innovatively matched quadruple Fin Lines to microstrip (FLuS transitions. At the date of this paper and at the Author's best knowledge no such FLuS innovative transitions have been reported in literature before. These transitions are inserted into a WR28 waveguide T-junction, in order to allow the integration of 16 Monolithic Microwave Integrated Circuit (MMIC Solid State Power Amplifiers (SSPA's. A computational electromagnetic model using the finite elements method has been implemented. A mean insertion loss of 2 dB is achieved with a return loss better the 10 dB in the 31-37 GHz bandwidth.

  18. Combining Stocks and Flows of Knowledge

    DEFF Research Database (Denmark)

    Ambos, Tina C.; Nell, Phillip Christopher; Pedersen, Torben

    In the area of knowledge management and knowledge governance, previous research has mostly focused on either knowledge stocks or knowledge flows of firms or organizational units. Contrary to this work, our study is among the first to integrate these two perspectives in order to shed light...... on the complementarity effects of different types of knowledge stocks and flows in the multinational corporation (MNC). We investigate intra-functional as well as cross-functional complementarity effects from the perspective of the knowledge recipient. We test the impact of stocks on flows on the benefit that is created...... for MNC units. Based on a comprehensive sample of 324 relationships between MNC units we find that both types of complementarity create benefits for these units, but that the effects from intra-functional combinations of knowledge stocks and flows are significantly stronger than from cross...

  19. [Combined forecasting system of peritonitis outcome].

    Science.gov (United States)

    Lebedev, N V; Klimov, A E; Agrba, S B; Gaidukevich, E K

    To create a reliable system for assessing of severity and prediction of the outcome of peritonitis. Critical analysis of the systems for peritonitis severity assessment is presented. The study included outcomes of 347 patients who admitted at the Department of Faculty Surgery of Peoples' Friendship University of Russia in 2015-2016. The cause of peritonitis were destructive forms of acute appendicitis, cholecystitis, perforated gastroduodenal ulcer, various perforation of small and large intestines (including tumor). Combined forecasting system for peritonitis severity assessment is created. The system includes clinical, laboratory data, assessment of systemic inflammatory response (SIRS) and severity of organ failure (qSOFA). The authors focused on easily identifiable parameters which are available in virtually any surgical hospital. Threshold value (lethal outcome probability over 50%) is 8 scores in this system. Sensitivity, specificity and accuracy were 93.3, 99.7 and 98.9%, respectively according to ROC-curve that exceeds those parameters of MPI and APACHE II.

  20. A puzzling combination: disorder X order

    International Nuclear Information System (INIS)

    Hasenfratz, P.

    1979-01-01

    There are several examples indicating that the operator combination 'disorder X order' creates anomalous spin and/or statistics. In 2 + 1 dimensions there is a similar anomaly related to the disorder operator carrying Z(N) topological charge believed to have an important role in quark confinement. The conventionally defined total angular momentum has an anomalous term 1/2 sigma 3 ((1/√3) lambda 8 ) and can take the values 1/2 (1/3) in the presence of 'disorder X order' in 2 + 1 dimensional SU(2) (SU(3)) gauge theories. It is argued that the existence of a stable soliton solution or the introduction of Higgs fields are not important for the anomaly. (Auth.)