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Sample records for hybrid micro lens

  1. Estimation of the hybrid lens parameters through rigid gas permeable lens fitting

    OpenAIRE

    Hasani, Mohammadali; Hashemi, Hassan; Jafarzadehpur, Ebrahim; Yekta, Abbas Ali; Dadbin, Nooshin; khabazkhoob, Mehdi

    2016-01-01

    Purpose To estimate the fitting parameters of the hybrid contact lens in patients with corneal ectasia using the rigid gas permeable (RGP) lens. Methods Thirty-four eyes with corneal ectasia were evaluated in this study. The patients were examined once with the RGP lens and once with the hybrid contact lens. The relationship between the base curvature of the RGP and the vault of the hybrid lens and the correlation between their powers were analyzed. Results We found a linear relationship betw...

  2. Preliminary of Optical Lens Design for Micro-Satellite

    Science.gov (United States)

    Rachim, Elvira; Mukhtar Tahir, Andi; Herawan, Agus

    2017-01-01

    The development of micro satellites for the last two decades is emerging rapidly as the need of satellite communication usage is increasing. Earth observation is one of the example of how satellites are on demand. Most observation satellites consist of sensors and imaging system on-board. One of the key element to have a good imaging system is a special optical lens system design. Such lens is designed specifically by calculating every parameter such as refractive, reflective indexes, type of surface, distance and many more. Manufactured lenses sometimes do not match the requirement of an imager system hence the special lens design is needed. This paper will first briefly describe the history of optic, theory related to lens system, then the design and the analysis of lens system for micro-satellites generally and LAPAN A4 particularly.

  3. Novel fabrication technique of hybrid structure lens array for 3D images

    Science.gov (United States)

    Lee, Junsik; Kim, Junoh; Kim, Cheoljoong; Shin, Dooseub; Koo, Gyohyun; Won, Yong Hyub

    2016-03-01

    Tunable liquid lens arrays can produce three dimensional images by using electrowetting principle that alters surface tensions by applying voltage. This method has advantages of fast response time and low power consumption. However, it is challenging to fabricate a high fill factor liquid lens array and operate three dimensional images which demand high diopter. This study describes a hybrid structure lens array which has not only a liquid lens array but a solid lens array. A concave-shape lens array is unavoidable when using only the liquid lens array and some voltages are needed to make the lens flat. By placing the solid lens array on the liquid lens array, initial diopter can be positive. To fabricate the hybrid structure lens array, a conventional lithographic process in semiconductor manufacturing is needed. A negative photoresist SU-8 was used as chamber master molds. PDMS and UV adhesive replica molding are done sequentially. Two immiscible liquids, DI water and dodecane, are injected in the fabricated chamber, followed by sealing. The fabricated structure has a 20 by 20 pattern of cylindrical shaped circle array and the aperture size of each lens is 1mm. The thickness of the overall hybrid structure is about 2.8mm. Hybrid structure lens array has many advantages. Solid lens array has almost 100% fill factor and allow high efficiency. Diopter can be increased by more than 200 and negative diopter can be shifted to the positive region. This experiment showed several properties of the hybrid structure and demonstrated its superiority.

  4. High efficiency micro solar cells integrated with lens array

    Science.gov (United States)

    Fidaner, Onur; Suarez, Ferran A.; Wiemer, Michael; Sabnis, Vijit A.; Asano, Tetsuya; Itou, Akihiro; Inoue, Daijiro; Hayashi, Nobuhiko; Arase, Hidekazu; Matsushita, Akio; Nakagawa, Tohru

    2014-03-01

    We demonstrate high efficiency triple junction solar cells with submillimeter dimensions in an all-back-contact architecture. 550 × 550 μm2 cells flash at 41.3% efficiency under the air mass 1.5 direct normal spectrum at 50 W/cm2 at 25 °C. Compared to standard size production cells, the micro cells have reduced performance at 1-sun due to perimeter recombination, but the performance gap closes at higher concentrations. Micro cells integrated with lens arrays were tested on-sun with an efficiency of 34.7%. All-back-contact architecture and submillimeter dimensions are advantageous for module integration and heat dissipation, allowing for high-performance, compact, lightweight, and cost-effective concentrated photovoltaic modules.

  5. Micro-Ball Lens Array Fabrication in Photoresist Using Ptfe Hydrophobic Effect

    CERN Document Server

    Shyu Ruey Fang; Tsai Wen Ren; Tsai Jhy Cherng

    2007-01-01

    This paper presents a simple method to fabricate micro-ball lens and its array. The key technology is to use the hydrophobic characteristics of polyterafluoroethylene (PTFE) substrate. High contact angle between melted photoresist pattern and PTFE can generate micro-ball lens and its array. PTFE thin film was spun onto a silicon wafer and dried in oven. Photoresist AZ4620 was used to pattern micro-columns with different diameters 60, 70 and 80 $\\mu$m. A thermal reflow process then was applied to melt these micro-column patterns resulted in micro-ball lens array. The achieved micro-ball lens array with diameter 98 $\\mu$m was fabricated using 80 $\\mu$m in diameter patterns. This method provides a simple fabrication process and low material cost.

  6. Fabrication of micro-lens array on convex surface by meaning of micro-milling

    Science.gov (United States)

    Zhang, Peng; Du, Yunlong; Wang, Bo; Shan, Debin

    2014-08-01

    In order to develop the application of the micro-milling technology, and to fabricate ultra-precision optical surface with complex microstructure, in this paper, the primary experimental research on micro-milling complex microstructure array is carried out. A complex microstructure array surface with vary parameters is designed, and the mathematic model of the surface is set up and simulated. For the fabrication of the designed microstructure array surface, a micro three-axis ultra-precision milling machine tool is developed, aerostatic guideway drove directly by linear motor is adopted in order to guarantee the enough stiffness of the machine, and novel numerical control strategy with linear encoders of 5nm resolution used as the feedback of the control system is employed to ensure the extremely high motion control accuracy. With the help of CAD/CAM technology, convex micro lens array on convex spherical surface with different scales on material of polyvinyl chloride (PVC) and pure copper is fabricated using micro tungsten carbide ball end milling tool based on the ultra-precision micro-milling machine. Excellent nanometer-level micro-movement performance of the axis is proved by motion control experiment. The fabrication is nearly as the same as the design, the characteristic scale of the microstructure is less than 200μm and the accuracy is better than 1μm. It prove that ultra-precision micro-milling technology based on micro ultra-precision machine tool is a suitable and optional method for micro manufacture of microstructure array surface on different kinds of materials, and with the development of micro milling cutter, ultraprecision micro-milling complex microstructure surface will be achieved in future.

  7. Fabrication of Aspheric Micro-Lens Mold with High Aspect Ratio

    Science.gov (United States)

    Naniwa, Irizo; Kanamaru, Masatoshi; Nakamura, Shigeo; Shimano, Takeshi; Horino, Masaya

    The optical pickup of our Small-Form-Factor Optical Disc Drives (SFFODDs) requires a micro-objective whose profile is composed of two aspheric surfaces. However, it is difficult to fabricate a micro-objective with an arbitrary aspheric surface and high aspect ratio using conventional techniques. We propose here a new method to fabricate an aspheric micro-lens mold with high aspect ratio. This method uses the micro-loading effect in Deep Reactive Ion Etching (DRIE) and isotropic Reactive Ion Etching (RIE). The micro-loading effect is a phenomenon that leads to different etching depths depending on the aperture size of the mask layer used in etching. We fabricated an aspheric micro-lens mold for the prototype by using the proposed method after experimental evaluations of the micro-loading effect for a feasibility study. The profile of the first prototype was slightly different from the designed one according as the distance from the lens center increase. The profile error of the second prototype was reduced by using a mask that had multiple apertures with the smallest aperture located outside the area where the crater was formed. Our proposed method was found to be effective for fabricating a micro-lens mold with an arbitrary aspheric surface and high aspect ratio.

  8. Formation of plano-convex micro-lens array in fused silica glass using CO2 laser assisted reshaping technique

    CERN Document Server

    Sohn, Ik-Bu; Yoo, Dongyoon; Noh, Young-Chul; Ahsan, Md Shamim; Sung, Jae-Hee; Lee, Seong-Ku

    2016-01-01

    We report on fabricating high-fill-factor plano-convex spherical and square micro-lens arrays on fused silica glass surface using CO2 laser assisted reshaping technique. Initially, periodic micro-pillars have been encoded on the glass surface by means of a femtosecond laser beam. Afterwards, the micro-pillars are polished several times by irradiating a CO2 laser beam on top of the micro-pillars. Consequently, spherical micro-lens array with micro-lens size of 50 um x 50 um and square micro-lens array with micro-lens size of 100 um x 100 um are formed on fused silica glass surface. We also study the intensity distribution of light passed through the spherical micro-lens array engraved glass sample. The simulation result shows that, the focal length of the spherical micro-lens array is 35 um. Furthermore, we investigate the optical properties of the micro-lens array engraved glass samples. The proposed CO2 laser based reshaping technique is simple and fast that shows promises in fabrication arrays of smooth mic...

  9. Electrically tunable micro-lens with a strain-enhanced polymer nanocomposite actuator (Conference Presentation)

    Science.gov (United States)

    Costache, Florenta A.; Pawlik, Boscij; Rieck, Andreas

    2017-02-01

    A fluid-filled micro-lens concept with an electrically driven polymer actuator was developed in view of optimization of its variation in focal length. The high strain electrostrictive terpolymer P(VDF-TrFE-CFE) was first used in the actuator design for this purpose. Our study showed that the electric field-induced strain in polymer thin films could be even further enhanced by mixing high-k BaTiO3 nanoparticles in the terpolymer. A newly developed nanocomposite P(VDF-TrFE-CFE) / BaTiO3 ring-shaped actuator was implemented into the 3 mm aperture, liquid-filled micro-lens concept. The micro-lens was fabricated in a wafer-level process flow, which included micromachining of fluidic chambers on silicon wafers, thin film nanocomposite actuator processing, assembly through wafer bonding and chip filling with liquids. Particular characteristics of the nanocomposite were taken into account such as the homogeneous nanoparticle dispersion into the thin film with impact on thin film dielectric breakdown, electrode adherence as well as nanocomposite film etching. Variable focal length micro-lenses conceps with a single fluidic chamber but also with two fluidic chambers (a design, which can potentially improve the lens membrane stability) were fabricated and characterized. We could demonstrate a wide focal length variation of tens of diopters first for a single chamber plano-convex micro-lens obtained by adjusting the voltage applied on the integrated actuator.

  10. A PDMS-Based Cylindrical Hybrid Lens for Enhanced Fluorescence Detection in Microfluidic Systems

    Directory of Open Access Journals (Sweden)

    Bor-Shyh Lin

    2014-02-01

    Full Text Available Microfluidic systems based on fluorescence detection have been developed and applied for many biological and chemical applications. Because of the tiny amount of sample in the system; the induced fluorescence can be weak. Therefore, most microfluidic systems deploy multiple optical components or sophisticated equipment to enhance the efficiency of fluorescence detection. However, these strategies encounter common issues of complex manufacturing processes and high costs. In this study; a miniature, cylindrical and hybrid lens made of polydimethylsiloxane (PDMS to improve the fluorescence detection in microfluidic systems is proposed. The hybrid lens integrates a laser focusing lens and a fluorescence collecting lens to achieve dual functions and simplify optical setup. Moreover, PDMS has advantages of low-cost and straightforward fabrication compared with conventional optical components. The performance of the proposed lens is first examined with two fluorescent dyes and the results show that the lens provides satisfactory enhancement for fluorescence detection of Rhodamine 6G and Nile Red. The overall increments in collected fluorescence signal and detection sensitivity are more than 220% of those without lens, and the detection limits of Rhodamine 6G and Nile red are lowered to 0.01 μg/mL and 0.05 μg/mL, respectively. The hybrid lens is further applied to the detection of Nile red-labeled Chlorella vulgaris cells and it increases both signal intensity and detection sensitivity by more than 520%. The proposed hybrid lens also dramatically reduces the variation in detected signal caused by the deviation in incident angle of excitation light.

  11. A PDMS-based cylindrical hybrid lens for enhanced fluorescence detection in microfluidic systems.

    Science.gov (United States)

    Lin, Bor-Shyh; Yang, Yu-Ching; Ho, Chong-Yi; Yang, Han-Yu; Wang, Hsiang-Yu

    2014-02-13

    Microfluidic systems based on fluorescence detection have been developed and applied for many biological and chemical applications. Because of the tiny amount of sample in the system; the induced fluorescence can be weak. Therefore, most microfluidic systems deploy multiple optical components or sophisticated equipment to enhance the efficiency of fluorescence detection. However, these strategies encounter common issues of complex manufacturing processes and high costs. In this study; a miniature, cylindrical and hybrid lens made of polydimethylsiloxane (PDMS) to improve the fluorescence detection in microfluidic systems is proposed. The hybrid lens integrates a laser focusing lens and a fluorescence collecting lens to achieve dual functions and simplify optical setup. Moreover, PDMS has advantages of low-cost and straightforward fabrication compared with conventional optical components. The performance of the proposed lens is first examined with two fluorescent dyes and the results show that the lens provides satisfactory enhancement for fluorescence detection of Rhodamine 6G and Nile Red. The overall increments in collected fluorescence signal and detection sensitivity are more than 220% of those without lens, and the detection limits of Rhodamine 6G and Nile red are lowered to 0.01 μg/mL and 0.05 μg/mL, respectively. The hybrid lens is further applied to the detection of Nile red-labeled Chlorella vulgaris cells and it increases both signal intensity and detection sensitivity by more than 520%. The proposed hybrid lens also dramatically reduces the variation in detected signal caused by the deviation in incident angle of excitation light.

  12. Development of 3d micro-nano hybrid patterns using anodized aluminum and micro-indentation

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Hong Gue; Kwon, Jong Tae [Division of Mechanical Engineering and Mechatronics, Kangwon National University, 1 Kangwondaehakgil, Chunchon, Gangwon-do, 200-701 (Korea, Republic of); Seo, Young Ho [Division of Mechanical Engineering and Mechatronics, Kangwon National University, 1 Kangwondaehakgil, Chunchon, Gangwon-do, 200-701 (Korea, Republic of)], E-mail: mems@kangwon.ac.kr; Kim, Byeong Hee [Division of Mechanical Engineering and Mechatronics, Kangwon National University, 1 Kangwondaehakgil, Chunchon, Gangwon-do, 200-701 (Korea, Republic of)

    2008-07-31

    We developed a simple and cost-effective method of fabricating 3D micro-nano hybrid patterns in which micro-indentation is applied on the anodized aluminum substrate. Nano-patterns were formed first on the aluminum substrate, and then micro-patterns were fabricated by deforming the nano-patterned aluminum substrate. Hemispherical nano-patterns with a 150 nm-diameter on an aluminum substrate were fabricated by anodizing and alumina removing process. Then, micro-pyramid patterns with a side-length of 50 {mu}m were formed on the nano-patterns using micro-indentation. To verify 3D micro-nano hybrid patterns, we replicated 3D micro-nano hybrid patterns by a hot-embossing process. 3D micro-nano hybrid patterns may be used in nano-photonic devices and nano-biochips applications.

  13. Large area laser surface micro/nanopatterning by contact microsphere lens arrays

    NARCIS (Netherlands)

    Sedao, X.; Derrien, T.J.Y.; Romer, G.R.B.E.; Pathiraj, B.; Huis in 't veld, A.J.

    2013-01-01

    Laser surface micro/nanopatterning by particle lens arrays is a well-known technique. Enhanced optical fields can be achieved on a substrate when a laser beam passes through a self-assembled monolayer of silica microspheres placed on the substrate. This enhanced optical field is responsible for abla

  14. Large area laser surface micro/nanopatterning by contact microsphere lens arrays

    NARCIS (Netherlands)

    Sedao, X.; Derrien, T.J.Y.; Romer, G.R.B.E.; Pathiraj, B.; Huis in 't veld, A.J.

    2013-01-01

    Laser surface micro/nanopatterning by particle lens arrays is a well-known technique. Enhanced optical fields can be achieved on a substrate when a laser beam passes through a self-assembled monolayer of silica microspheres placed on the substrate. This enhanced optical field is responsible for

  15. Lead-acid batteries in micro-hybrid vehicles

    Science.gov (United States)

    Albers, Joern; Meissner, Eberhard; Shirazi, Sepehr

    More and more vehicles hit the European automotive market, which comprise some type of micro-hybrid functionality to improve fuel efficiency and reduce emissions. Most carmakers already offer at least one of their vehicles with an optional engine start/stop system, while some other models are sold with micro-hybrid functions implemented by default. But these car concepts show a wide variety in detail-the term "micro-hybrid" may mean a completely different functionality in one vehicle model compared to another. Accordingly, also the battery technologies are not the same. There is a wide variety of batteries from standard flooded and enhanced flooded to AGM which all are claimed to be "best choice" for micro-hybrid applications. A technical comparison of micro-hybrid cars available on the European market has been performed. Different classes of cars with different characteristics have been identified. Depending on the scope and characteristics of micro-hybrid functions, as well as on operational strategies implemented by the vehicle makers, the battery operating duties differ significantly between these classes of vehicles. Additional laboratory investigations have been carried out to develop an understanding of effects observed in batteries operated in micro-hybrid vehicles pursuing different strategies, to identify limitations for applications of different battery technologies.

  16. Automated Micro-Object Detection for Mobile Diagnostics Using Lens-Free Imaging Technology

    Directory of Open Access Journals (Sweden)

    Mohendra Roy

    2016-05-01

    Full Text Available Lens-free imaging technology has been extensively used recently for microparticle and biological cell analysis because of its high throughput, low cost, and simple and compact arrangement. However, this technology still lacks a dedicated and automated detection system. In this paper, we describe a custom-developed automated micro-object detection method for a lens-free imaging system. In our previous work (Roy et al., we developed a lens-free imaging system using low-cost components. This system was used to generate and capture the diffraction patterns of micro-objects and a global threshold was used to locate the diffraction patterns. In this work we used the same setup to develop an improved automated detection and analysis algorithm based on adaptive threshold and clustering of signals. For this purpose images from the lens-free system were then used to understand the features and characteristics of the diffraction patterns of several types of samples. On the basis of this information, we custom-developed an automated algorithm for the lens-free imaging system. Next, all the lens-free images were processed using this custom-developed automated algorithm. The performance of this approach was evaluated by comparing the counting results with standard optical microscope results. We evaluated the counting results for polystyrene microbeads, red blood cells, and HepG2, HeLa, and MCF7 cells. The comparison shows good agreement between the systems, with a correlation coefficient of 0.91 and linearity slope of 0.877. We also evaluated the automated size profiles of the microparticle samples. This Wi-Fi-enabled lens-free imaging system, along with the dedicated software, possesses great potential for telemedicine applications in resource-limited settings.

  17. Hybrid micro-/nanogels for optical sensing and intracellular imaging

    Directory of Open Access Journals (Sweden)

    Shuiqin Zhou

    2010-12-01

    Full Text Available Hybrid micro-/nanogels are playing an increasing important part in a diverse range of applications, due to their tunable dimensions, large surface area, stable interior network structure, and a very short response time. We review recent advances and challenges in the developments of hybrid micro-/nanogels toward applications for optical sensing of pH, temperature, glucose, ions, and other species as well as for intracellular imaging. Due to their unique advantages, hybrid micro-/nanogels as optical probes are attracting substantial interests for continuous monitoring of chemical parameters in complex samples such as blood and bioreactor fluids, in chemical research and industry, and in food quality control. In particular, their intracellular probing ability enables the monitoring of the biochemistry and biophysics of live cells over time and space, thus contributing to the explanation of intricate biological processes and the development of novel diagnoses. Unlike most other probes, hybrid micro-/nanogels could also combine other multiple functions into a single probe. The rational design of hybrid micro-/nanogels will not only improve the probing applications as desirable, but also implement their applications in new arenas. With ongoing rapid advances in bionanotechnology, the well-designed hybrid micro-/nanogel probes will be able to provide simultaneous sensing, imaging diagnosis, and therapy toward clinical applications.

  18. Enhanced Surface-Plasmon-Polariton Interference for Nanolithography by a Micro-Cylinder-Lens Array

    Institute of Scientific and Technical Information of China (English)

    LIANG Hui-Min; WANG Jing-Quan; FAN Feng; QIN Ai-Li; ZHANG Chun-Yuan; CHENG Hui

    2010-01-01

    @@ A practical interference lithography scheme based on surface plasmon polaritions (SPPs) is suggested.In this scheme,a micro-cylinder-lens array is employed to generate the evanescent wave (EW) carrying much energy.When the top of the cylinder lenses are in dose contact with a metal film coated on a resist,the energy of EW will launch strong SPPs and form enhanced interference nanopatterns in the resist.

  19. First results of micro-neutron tomography by use of a focussing neutron lens

    CERN Document Server

    Masschaele, B; Cauwels, P; Dierick, M; Jolie, J; Mondelaers, W

    2001-01-01

    Since the appearance of high flux neutron beams, scientists experimented with neutron radiography. This high beam flux combined with modern neutron to visible light converters leads to the possibility of performing fast neutron micro-tomography. The first results of cold neutron tomography with a neutron lens are presented in this article. Samples are rotated in the beam and the projections are recorded with a neutron camera. The 3D reconstruction is performed with cone beam reconstruction software.

  20. Technology for fabricating micro-lens arrays utilizing lithographically replicated concave resist patterns

    Science.gov (United States)

    Kobayashi, Noa; Sasaki, Ryunosuke; Horiuchi, Toshiyuki

    2016-05-01

    Lithography has been generally used for printing two-dimensional patterns on flat wafers. Recently, however, it is also applied to a three-dimensional patterning for fabricating various MEMS (Micro Electro Mechanical Systems) components. The purpose of this research is to develop a new method for fabricating micro-lens arrays. At first, resist (Tokyo Ohka Kogyo, PMER LA-900PM) mold patterns with densely arrayed square or hexagonal concaves were replicated by intentionally shifting the focal position of projection exposure. The size of resist-mold was 2 mm square, and the initial thickness of the resist was 10 μm. Next, the wafer with the concave resist patterns was cut into small chips, and each wafer chip was fixed at the bottom of a paper cup using an adhesive tape. Then the epoxy resin (Nissin resin, Crystal resin Neo) was poured on the concave resist-mold patterns, and the resin was coagulated. Afterward, the hardened resin was grooved along the wafer chip using a cutter knife, and the wafer chip with the resist-mold patterns was forcibly removed using a pair of tweezers. Finally, both sides of the resin block were polished, and the thickness was reduced. Although the transparency and roughness of the resin block surfaces should be improved, epoxy micro-lens arrays were certainly fabricated. The mean values of curvature radius and lens height were 28.3μm and 4.9 μm, respectively.

  1. Laser surface micro-/nano-structuring by a simple transportable micro-sphere lens array

    NARCIS (Netherlands)

    Sedao, X.; Derrien, T.J.Y.; Romer, G.W.R.B.E.; Pathiraj, B.; Huis in 't Veld, A.J.

    2012-01-01

    A micro-sphere array optic was employed for laser surface micro-structuring. This array optic consists of a hexagonally close-packed monolayer of silica micro-spheres. It was organized through a self-assembly process and held together on a glass support, without using any adhesives. The array assemb

  2. Laser surface micro-/nano-structuring by a simple transportable micro-sphere lens array

    NARCIS (Netherlands)

    Sedao, X.; Derrien, T.J.Y.; Romer, G.W.R.B.E.; Pathiraj, B.; Huis in 't Veld, A.J.

    2012-01-01

    A micro-sphere array optic was employed for laser surface micro-structuring. This array optic consists of a hexagonally close-packed monolayer of silica micro-spheres. It was organized through a self-assembly process and held together on a glass support, without using any adhesives. The array

  3. Multiocular image sensor with on-chip beam-splitter and inner meta-micro-lens for single-main-lens stereo camera.

    Science.gov (United States)

    Koyama, Shinzo; Onozawa, Kazutoshi; Tanaka, Keisuke; Saito, Shigeru; Kourkouss, Sahim Mohamed; Kato, Yoshihisa

    2016-08-01

    We developed multiocular 1/3-inch 2.75-μm-pixel-size 2.1M- pixel image sensors by co-design of both on-chip beam-splitter and 100-nm-width 800-nm-depth patterned inner meta-micro-lens for single-main-lens stereo camera systems. A camera with the multiocular image sensor can capture horizontally one-dimensional light filed by both the on-chip beam-splitter horizontally dividing ray according to incident angle, and the inner meta-micro-lens collecting the divided ray into pixel with small optical loss. Cross-talks between adjacent light field images of a fabricated binocular image sensor and of a quad-ocular image sensor are as low as 6% and 7% respectively. With the selection of two images from one-dimensional light filed images, a selective baseline for stereo vision is realized to view close objects with single-main-lens. In addition, by adding multiple light field images with different ratios, baseline distance can be tuned within an aperture of a main lens. We suggest the electrically selective or tunable baseline stereo vision to reduce 3D fatigue of viewers.

  4. Ultrafast laser driven micro-lens to focus and energy select MeV protons

    Energy Technology Data Exchange (ETDEWEB)

    Toncian, Toma

    2008-05-15

    A technique for simultaneous focusing and energy selection of high-current, MeV proton beams using radial, transient electric fields (10{sup 7}-10{sup 10} V/m) triggered on the inner wall of a hollow micro-cylinder by an intense, sub-picosecond laser-pulse is presented. Due to the transient nature of the radial focusing field, the proposed method allows selection of a desired range out of the spectrum of the poly-energetic proton beam. This technique addresses current drawbacks of laser-accelerated proton beams, i.e. their broad spectrum and divergence at the source. This thesis presents both experimental and computational studies that led to the understanding of the physical processes driving the micro-lens. After an one side irradiation of a hollow metallic cylinder a radial electric field develops inside the cylinder. Hot electrons generated by the interaction between laser pulse and cylinder wall spread inside the cylinder generating a plasma at the wall. This plasma expands into vacuum and sustains an electric field that acts as a collecting lens on a proton beam propagating axially through the cylinder. Both focusing and the reduction of the intrinsic beam divergence from 20 deg to.3 deg for a narrow spectral range was demonstrated. By sub-aperturing the beam a narrow spectral range ({delta}{epsilon}/{epsilon} < 3%) was selected from the poly-energetic beam. The micro-lens properties are tunable allowing for optimization towards applications. Optical probing techniques and proton imaging were employed to study the spacial and temporal evolution of the field and revealed a complex physical scenario of the rise and decay of the radial electric field. Each aspect studied experimentally is interpreted using 2D PIC and ray tracing simulations. A very good agreement between the experimental and computational data is found. The PIC simulations are used to upscale the demonstrated micro-lens capabilities to the focusing of a 270 MeV proton beam, an energy relevant

  5. The Development of a Hybrid Underwater Micro Biped Robot

    Directory of Open Access Journals (Sweden)

    S. Guo

    2006-01-01

    Full Text Available There has been a great demand, in the medical field and in industrial applications, for a novel micro biped robot with multiple degrees of freedom that can swim smoothly in water or in aqueous medium. The fish-like micro-robot studied is a type of miniature device that is installed with sensing and actuating elements. This article describes the new structure and motion mechanism of a hybrid type of underwater micro-robot using an ion-conducting polymer film (ICPF actuator, and discusses the swimming and floating characteristics of the micro-robot in water, measured by changing the voltage frequency and the amplitude of the input voltage. Results indicate that the swimming speed of the proposed underwater micro-robot can be controlled by changing the frequency of the input voltage, and the direction (upward or downward can be manipulated by changing the frequency of the electric current applied and the amplitude of the voltage.

  6. Micro-lens array design on a flexible light-emitting diode package for indoor lighting.

    Science.gov (United States)

    Lee, Hsiao-Wen; Lin, Bor-Shyh

    2015-10-01

    An advanced, ultra-thin, flexible LED (FLED) package technique is first proposed in this study, where a polyimide substrate was used as the lead frame package material due to its physical stability in thermal processing. The experimental results showed that the thickness of the mockup sample measured by a vernier caliper was 260 μm and 35% thinner than the Panasonic organic LED lighting panel announced on 4 March 2014 in Tokyo. Moreover, the flexible angle of the ultra-thin LED package was 200.54° when it surrounded a disk with a 1 cm radius. A design of a micro-lens array manufactured by silicone molding on the FLED is also proposed in this study. Finally, different types of micro-lenses were applied to different lighting regions to investigate their lighting effects.

  7. A hybrid sequential deposition fabrication technique for micro fuel cells

    Science.gov (United States)

    Stanley, Kevin G.; Czyzewska, Eva K.; Vanderhoek, Tom P. K.; Fan, Lilian L. Y.; Abel, Keith A.; Wu, Q. M. Jonathan; Parameswaran, M. Ash

    2005-10-01

    Micro fuel cell systems have elicited significant interest due to their promise for instantly rechargeable, longer duration and portable power. Most micro fuel cell systems are either built as miniaturized plate-and-frame or silicon-based microelectromechanical systems (MEMS). Plate-and-frame systems are difficult to fabricate smaller than 20 cm3. Existing micro fuel cell designs cannot meet the cost, scale and power requirements of some portable power markets. Traditional MEMS scaling advantages do not apply to fuel cells because the minimum area for the fuel cell is fixed by the catalyst area required for a given power output, and minimum volume set by mass transport limitations. We have developed a new hybrid technique that borrows from both micro and macro machining techniques to create fuel cells in the 1-20 cm3 range, suitable for cell phones, PDAs and smaller devices.

  8. Enhanced light extraction efficiency of chip-on board light-emitting diodes through micro-lens array fabricated by ion wind

    Science.gov (United States)

    Chu, Jingcao; Lei, Xiang; Wu, Jiading; Peng, Yang; Liu, Sheng; Yang, Qian; Zheng, Huai

    2017-03-01

    Low light extraction efficiency (LEE) is a key challenge of chip-on board (COB) packaging light-emitting diodes (LEDs). In this paper, a facile preparation of micro-lens array was proposed based on the ion wind patterning. The geometries and sizes of the micro-lens arrays were controlled through adjusting the voltage parameter of the ion wind generation. Consequently, the micro-lens array with the diameter of 180 μm and the gap distance of 15 μm has been fabricated. Benefitting from this micro-lens array, the LEE of COB packaging LEDs was enhanced by 9%. This facile fabrication of micro-lens array would be a promising method to improve the LEE of COB packaging LEDs.

  9. Bacterial Bioburden Decrease in Orthokeratology Lens Storage Cases After Forewarning: Assessment by the DNA Dot Hybridization Assay.

    Science.gov (United States)

    Fang, Po-Chiung; Lo, Jung; Chang, Tsung C; Chien, Chun-Chih; Hsiao, Chang-Chun; Tseng, Shin-Ling; Lai, Yu-Hsuan; Kuo, Ming-Tse

    2017-05-01

    The aim of this study was to measure the changes in the bacterial bioburden in orthokeratology (OK) lens storage cases using the DNA dot hybridization assay (DHA) after forewarning patients about their bacterial contamination severity. Thirty-one OK lens wearers were prospectively enrolled in this study. Dot hybridization assay was used for serial measurements of bacterial bioburden in OK storage cases after lenses had been soaked for approximately 6 hr. After the first assessment, the lens wearers were informed of the extent of case contamination and the possible risk of microbial keratitis (MK), and best practices for lens care and lens case hygiene were reviewed and reinforced. A second assessment by the same DHA method was performed after approximately 6 months. Two universal bacterial probes confirmed a significant decrease in bacterial bioburden at the second assessment (P<0.01 and P<0.001). Genus-specific probes showed significant reductions in Acinetobacter and Klebsiella (P=0.02 and P=0.01), but not in Pseudomonas (P=0.42). Making OK lens wearers aware of the bacterial bioburden in their lens cases resulted in improved quality of case care and reduced bioburden. Our results suggest that a strategy of bioburden assessment with forewarning could be a useful method to decrease the incidence of OK-related MK.

  10. Large area laser surface micro/nanopatterning by contact microsphere lens arrays

    Science.gov (United States)

    Sedao, X.; Derrien, T. J.-Y.; Romer, G. R. B. E.; Pathiraj, B.; Huis in `t Veld, A. J.

    2013-06-01

    Laser surface micro/nanopatterning by particle lens arrays is a well-known technique. Enhanced optical fields can be achieved on a substrate when a laser beam passes through a self-assembled monolayer of silica microspheres placed on the substrate. This enhanced optical field is responsible for ablative material removal from the substrate resulting in a patterned surface. Because of the laser ablation, the microspheres are often ejected from the substrate during laser irradiation. This is a major issue impeding this technique to be used for large area texturing. We explored the possibility to retain the spheres on the substrate surface during laser irradiation. A picosecond laser system (wavelength of 515 nm, pulse duration 6.7 ps, repetition rate 400 kHz) was employed to write patterns through the lens array on a silicon substrate. In this experimental study, the pulse energy was found to be a key factor to realize surface patterning and retain the spheres during the process. When the laser pulse energy is set within the process window, the microspheres stay on the substrate during and after laser irradiation. Periodic patterns of nanoholes can be textured on the substrate surface. The spacing between the nanoholes is determined by the diameter of the microspheres. The depth of the nanoholes varies, depending on the number of laser pulses applied and pulse energy. Large area texturing can be made using overlapping pulses obtained through laser beam scanning.

  11. New high fill-factor triangular micro-lens array fabrication method using UV proximity printing

    CERN Document Server

    Lin, T -H; Chao, C -K

    2008-01-01

    A simple and effective method to fabricate a high fill-factor triangular microlens array using the proximity printing in lithography process is reported. The technology utilizes the UV proximity printing by controlling a printing gap between the mask and substrate. The designed approximate triangle microlens array pattern can be fabricated the high fill-factor triangular microlens array in photoresist. It is due to the UV light diffraction to deflect away from the aperture edges and produce a certain exposure in photoresist material outside the aperture edges. This method can precisely control the geometric profile of high fill factor triangular microlens array. The experimental results showed that the triangular micro-lens array in photoresist could be formed automatically when the printing gap ranged from 240 micrometers to 840 micrometers. The gapless triangular microlens array will be used to increases of luminance for backlight module of liquid crystal displays.

  12. High-efficiency thin and compact concentrator photovoltaics with micro-solar cells directly attached to a lens array.

    Science.gov (United States)

    Hayashi, Nobuhiko; Inoue, Daijiro; Matsumoto, Mitsuhiro; Matsushita, Akio; Higuchi, Hiroshi; Aya, Youichirou; Nakagawa, Tohru

    2015-06-01

    We propose a thin and compact concentrator photovoltaic (CPV) module, about 20 mm thick, one tenth thinner than those of conventional CPVs that are widely deployed for mega-solar systems, to broaden CPV application scenarios. We achieved an energy conversion efficiency of 37.1% at a module temperature of 25 °C under sunlight irradiation optimized for our module. Our CPV module has a lens array consisting of 10 mm-square unit lenses and micro solar cells that are directly attached to the lens array, to reduce the focal length of the concentrator and to reduce optical losses due to reflection. The optical loss of the lens in our module is about 9.0%, which is lower than that of conventional CPV modules with secondary optics. This low optical loss enables our CPV module to achieve a high energy conversion efficiency.

  13. Development and applications of grazing exit micro X-ray fluorescence instrument using a polycapillary X-ray lens*1

    Science.gov (United States)

    Emoto, T.; Sato, Y.; Konishi, Y.; Ding, X.; Tsuji, K.

    2004-08-01

    A polycapillary X-ray lens is an effective optics to obtain a μm-size X-ray beam for micro-X-ray fluorescence spectrometry (μ-XRF). We developed a μ-XRF instrument using a polycapillary X-ray lens, which also enabled us to perform Grazing Exit μ-XRF (GE-μ-XRF). The evaluated diameter of the primary X-ray beam was 48 μm at the focal distance of the X-ray lens. Use of this instrument enabled two-dimensional mapping of the elemental distributions during growth of the plant "Quinoa". The results of the mapping revealed elemental transition during growth. In addition, a small region of thin film was analyzed by GE-μ-XRF. We expect that GE-μ-XRF will become an effective method of estimating the film thickness of a small region.

  14. Development and applications of grazing exit micro X-ray fluorescence instrument using a polycapillary X-ray lens

    Energy Technology Data Exchange (ETDEWEB)

    Emoto, T.; Sato, Y.; Konishi, Y.; Ding, X.; Tsuji, K. E-mail: tsuji@a-chem.eng.osaka-cu.ac.jp

    2004-08-31

    A polycapillary X-ray lens is an effective optics to obtain a {mu}m-size X-ray beam for micro-X-ray fluorescence spectrometry ({mu}-XRF). We developed a {mu}-XRF instrument using a polycapillary X-ray lens, which also enabled us to perform Grazing Exit {mu}-XRF (GE-{mu}-XRF). The evaluated diameter of the primary X-ray beam was 48 {mu}m at the focal distance of the X-ray lens. Use of this instrument enabled two-dimensional mapping of the elemental distributions during growth of the plant 'Quinoa'. The results of the mapping revealed elemental transition during growth. In addition, a small region of thin film was analyzed by GE-{mu}-XRF. We expect that GE-{mu}-XRF will become an effective method of estimating the film thickness of a small region.

  15. Design and fabrication of an elliptical micro-lens array with grating for laser safety

    Science.gov (United States)

    Li, L. H.; Wu, B. Q.; Chan, C. Y.; Lee, W. B.; Dong, L. H.

    2015-10-01

    With the enormous expansion of laser usage in medicine, industry and research, all facilities must formulate and adhere to specific safety methods that appropriately address user protection. The protective ellipticalal microstructure with grating is a novel technology which can provide the principal means of ensuring against ocular injury, and must be worn at all times during laser operation. On the basis of Fresnel's law and the diffractive law, Solidworks and Lighttools software are applied to design the elliptical micro-lens array and correspondent grating. The height of the microstructure is 100um and its period is 3mm. The period of grating is 5um. It is shown that the amount of emergent light of a specific wavelength (1064nm) can reflect more than 40° from the incident light through simulation, while the incident light is perpendicular to the microstructure. The fabrication adopts the ultra-precision single point diamond method and injection molding method. However, it is found in the test that the surface roughness has a serious effect on the angle between the emergent and incident light. As a result, the element can reflect the vertical incidence beam into a tilted emergent beam with a certain angular degree , as well as protecting users from laser damage injures.

  16. Hybrid Energy Scheduling in a Renewable Micro Grid

    Directory of Open Access Journals (Sweden)

    Zifa Liu

    2015-09-01

    Full Text Available In this paper, we address the energy scheduling issue in a hybrid energy micro grid, which consists of photovoltaic (PV, wind power, combined heat and power (CHP, energy storage and electric vehicles (EVs. The optimal scheduling model of these power sources is presented with consideration of the demand response. The objective function is minimum total operation costs, including gas cost, electric power purchase from the main grid and storage and EV charging-discharging costs. In the process of optimization, multi-team particle swarm optimization (MTPSO is proposed, which uses units, groups and swarm information to update the velocity (position with faster and more stable convergence. With simulation analysis, it is found that the proposed model is effective, and the presented MTPSO has a better global search ability than PSO.

  17. Low f-number photoacoustic lens for tight ultrasonic focusing and free-field micro-cavitation in water

    Science.gov (United States)

    Lee, Taehwa; Ok, Jong G.; Guo, L. Jay; Baac, Hyoung Won

    2016-03-01

    We demonstrate a photoacoustic lens with a low f-number of 0.61 and a high focal gain of 220 at 15-MHz frequency for laser-generated focused ultrasound (LGFU), which enables free-field micro-cavitation in water. Due to tight ultrasonic focusing (90 μm in lateral and 200 μm in longitudinal spot widths at a distance of 9.2 mm), the lens produces a peak pressure of 20 MPa (positive) using an input laser energy of only 1 mJ/pulse (6-ns temporal width). Remarkably, we confirm single-pulsed micro-cavitation in a free-field condition by using this lens, which has not previously been achieved with LGFU. The free-field cavitation was monitored and characterized in terms of a bubble radius, a lifetime, and a probability. Our result demonstrates that LGFU amplitudes can be sufficiently higher than a threshold for free-field cavitation at a microscale spot, which is a crucial step for cavitation-based therapy with high precision.

  18. Relative biocompatibility of micro-hybrid and nano-hybrid light-activated composite resins.

    Science.gov (United States)

    Olabisi Arigbede, Abiodun; Folasade Adeyemi, Bukola; Femi-Akinlosotu, Omowumi

    2017-01-01

    Background. In vitro studies have revealed a direct association between resin content and cytotoxicity of composite resins; however, implantation studies in this regard are sparse. This study investigates the relationship between filler content of composite resins and biocompatibility. Methods. This research employed twelve 180‒200-gr male Wistar rats, 1 nano-hybrid (Prime-Dent Inc.) and 1 micro-hybrid (Medental Inc.) composite resins containing 74% and 80‒90% filler content, respectively. The samples were assessed on the 2nd, 14th and 90th day of implantation. Four rats were allocated to each day in this experimental study. A section of 1.5mm long cured nano-hybrid and micro-hybrid materials were implanted into the right and left upper and lower limbs of the rats, respectively. Eight samples were generated on each day of observation. Inflammation was graded according to the criteria suggested by Orstavik and Major. Pearson's chi-squared test was employed to determine the relationship between the tissue responses of the two materials. Statistical significance was set at P composite resins with higher filler content elicited a significantly lower grade of inflammation irrespective of the duration (χ=20.000, df=8, P=0.010) while the composite resins with lower filler content elicited a significantly lower inflammatory response on the 90th day (χ=4.000, df=1, P=0.046). Conclusion. The composite resins with higher filler content generally elicited significantly lower grades of inflammation, and the composite resins with lower filler content exhibited significantly lower inflammatory response on the 90th day of implantation.

  19. Contact lens in keratoconus

    Directory of Open Access Journals (Sweden)

    Varsha M Rathi

    2013-01-01

    Full Text Available Contact lenses are required for the visual improvement in patients with keratoconus. Various contact lens options, such as rigid gas permeable (RGP lenses, soft and soft toric lenses, piggy back contact lenses (PBCL, hybrid lenses and scleral lenses are availble. This article discusses about selection of a lens depending on the type of keratoconus and the fitting philosophies of various contact lenses including the starting trial lens. A Medline search was carried out for articles in the English language with the keywords keratoconus and various contact lenses such as Rose k lens, RGP lens, hybrid lens, scleral lens and PBCL.

  20. Hybrid silencers with micro-perforated panels and internal partitions.

    Science.gov (United States)

    Yu, Xiang; Cheng, Li; You, Xiangyu

    2015-02-01

    A sub-structuring approach, along with a unit cell treatment, is proposed to model expansion chamber silencers with internal partitions and micro-perforated panels (MPPs) in the absence of internal flow. The side-branch of the silencer is treated as a combination of unit cells connected in series. It is shown that, by connecting multiple unit cells with varying parameters, the noise attenuation bandwidth can be enlarged. With MPPs, the hybrid noise attenuation mechanism of the silencer is revealed. Depending on the size of the perforation hole, noise attenuation can be dominated by dissipative, reactive, or combined effects together. For a broadband sound absorption, the hole size, together with the perforation ratio and other parameters, can be optimized to strike a balance between the dissipative and reactive effect, for ultimately achieving the desired noise attenuation performance within a prescribed frequency region. The modular nature of the proposed formulation allows doing this in a flexible, accurate, and cost effective manner. The accuracy of the proposed approach is validated through comparisons with finite element method and experiments.

  1. A novel Michelson Fabry-Perot hybrid interference sensor based on the micro-structured fiber

    Science.gov (United States)

    Zhang, Yaxun; Zhang, Yu; Wang, Zhenzhen; Liu, Zhihai; Wei, Yong; Zhao, Enming; Yang, Xinghua; Zhang, Jianzhong; Yang, Jun; Yuan, Libo

    2016-09-01

    We propose and demonstrate a novel Michelson Fabry-Perot hybrid fiber interference sensor. By integrating a Michelson interferometer in a two-core fiber and a Fabry-Perot interferometer in a micro silica-capillary, we produce the Michelson Fabry-Perot hybrid interference sensor. Owing to the structure characteristic of the micro-structured fiber, this hybrid fiber interference sensor can achieve the measurement of the axial strain and radial bending simultaneously. The measurement sensitivity of the axial train is 0.015 nm/με and the measurement sensitivity of the radial bending is 1.393 nm/m-1.

  2. Lid and conjunctival micro biota during contact lens wear in children.

    Science.gov (United States)

    Sankaridurg, Padmaja R; Markoulli, Maria; de la Jara, Percy Lazon; Harmis, Najat; Varghese, Thomas; Willcox, Mark D P; Holden, Brien A

    2009-04-01

    To determine the types of microorganisms and their frequency of isolation on the external ocular surface in children wearing soft contact lenses on a daily wear schedule. Children aged 8 to 14 years were fitted with commercially available, soft contact lenses which were worn on a daily wear basis. The upper bulbar conjunctiva and the lower lid margins of each eye were swabbed at baseline and then at 6-monthly intervals for 2 years during lens wear. Swabs were processed, cultured and microorganisms identified using standard microbiological techniques. At baseline, 36% of the upper bulbar conjunctivae and 53% of the lower lid margins were contaminated with predominantly gram-positive bacteria. Recovery of samples with positive growth from the upper bulbar conjunctivae decreased during lens wear and ranged from 27 to 14%. The difference was statistically significant at the 12-month visit(14%, p = 0.011). The lower lid margins generally showed similar levels of contamination as at baseline except for less contamination at the 12-month visit (33%) (p = 0.05). Staphylococcus epidermidis and Propionibacterium sp. were the predominant microorganisms isolated from both the sites with and without lens wear. Gram-negative bacteria were infrequent and when isolated, the numbers of colonies were few. Fungus was isolated in a small percent (ranging from 0 to 4.8%) of eyes at various time points. The external ocular surface of children is contaminated with gram-positive bacteria that are resident microbiota. During lens wear, there was a trend for lesser recovery of organisms from the upper bulbar conjunctival samples,but there was no change in the type of microorganisms isolated. At all times, lower lid margins showed consistently greater colonization and is a source of potential contamination of the conjunctival surface.

  3. Micro tooling technologies for polymer micro replication: direct, indirect and hybrid process chains

    DEFF Research Database (Denmark)

    Tosello, Guido; Hansen, Hans Nørgaard

    2009-01-01

    and performance of the corresponding micro mould. Traditional methods of micro tooling, such as various machining processes (e.g. micro milling, micro electrical discharge machining) have already reached their limitations with decreasing dimensions of mould inserts and cavities. To this respect, tooling process...

  4. Mathematical simulation of the optical system of a fiber-optic measuring micro motion converter with a cylindrical lens modulation element

    Science.gov (United States)

    Murashkina, T. I.; Motin, A. V.; Badeeva, E. A.

    2017-01-01

    The paper presents the results of mathematical modeling to determine the physical, structural and technological parameters of differential fiber-optic micro motion converters with a cylindrical lens, which are basic elements of the technical solutions for fiber-optic sensors of various physical quantities used in the industry in automated control systems.

  5. Optimizing laser beam profiles using micro-lens arrays for efficient material processing: applications to solar cells

    Science.gov (United States)

    Hauschild, Dirk; Homburg, Oliver; Mitra, Thomas; Ivanenko, Mikhail; Jarczynski, Manfred; Meinschien, Jens; Bayer, Andreas; Lissotschenko, Vitalij

    2009-02-01

    High power laser sources are used in various production tools for microelectronic products and solar cells, including the applications annealing, lithography, edge isolation as well as dicing and patterning. Besides the right choice of the laser source suitable high performance optics for generating the appropriate beam profile and intensity distribution are of high importance for the right processing speed, quality and yield. For industrial applications equally important is an adequate understanding of the physics of the light-matter interaction behind the process. In advance simulations of the tool performance can minimize technical and financial risk as well as lead times for prototyping and introduction into series production. LIMO has developed its own software founded on the Maxwell equations taking into account all important physical aspects of the laser based process: the light source, the beam shaping optical system and the light-matter interaction. Based on this knowledge together with a unique free-form micro-lens array production technology and patented micro-optics beam shaping designs a number of novel solar cell production tool sub-systems have been built. The basic functionalities, design principles and performance results are presented with a special emphasis on resilience, cost reduction and process reliability.

  6. Large-scale fabrication of micro-lens array by novel end-fly-cutting-servo diamond machining.

    Science.gov (United States)

    Zhu, Zhiwei; To, Suet; Zhang, Shaojian

    2015-08-10

    Fast/slow tool servo (FTS/STS) diamond turning is a very promising technique for the generation of micro-lens array (MLA). However, it is still a challenge to process MLA in large scale due to certain inherent limitations of this technique. In the present study, a novel ultra-precision diamond cutting method, as the end-fly-cutting-servo (EFCS) system, is adopted and investigated for large-scale generation of MLA. After a detailed discussion of the characteristic advantages for processing MLA, the optimal toolpath generation strategy for the EFCS is developed with consideration of the geometry and installation pose of the diamond tool. A typical aspheric MLA over a large area is experimentally fabricated, and the resulting form accuracy, surface micro-topography and machining efficiency are critically investigated. The result indicates that the MLA with homogeneous quality over the whole area is obtained. Besides, high machining efficiency, extremely small volume of control points for the toolpath, and optimal usage of system dynamics of the machine tool during the whole cutting can be simultaneously achieved.

  7. Hybrid Spectral Micro-CT: System Design, Implementation, and Preliminary Results

    CERN Document Server

    Bennett, James R; Xu, Qiong; Yu, Hengyong; Walsh, Michael; Butler, Anthony; Butler, Phillip; Cao, Guohua; Mohs, Aaron; Wang, Ge

    2014-01-01

    Spectral CT has proven an important development in biomedical imaging, and there have been several publications in the past years demonstrating its merits in pre-clinical and clinical applications. In 2012, Xu et al. reported that near-term implementation of spectral micro-CT could be enhanced by a hybrid architecture: a narrow-beam spectral "interior" imaging chain integrated with a traditional wide-beam "global" imaging chain. This hybrid integration coupled with compressive sensing (CS)-based interior tomography demonstrated promising results for improved contrast resolution, and decreased system cost and radiation dose. The motivation for the current study is implementation and evaluation of the hybrid architecture with a first-of-its-kind hybrid spectral micro-CT system. Preliminary results confirm improvements in both contrast and spatial resolution. This technology is shown to merit further investigation and potential application in future spectral CT scanner design.

  8. Design and implementation of a hybrid circuit system for micro sensor signal processing

    Energy Technology Data Exchange (ETDEWEB)

    Wang Zhuping; Chen Jing; Liu Ruqing, E-mail: wangzhuping169@163.com [School of Information and Electronics, Beijing Institute of Technology, Beijing 100081 (China)

    2011-04-15

    This paper covers a micro sensor analog signal processing circuit system (MASPS) chip with low power and a digital signal processing circuit board implementation including hardware connection and software design. Attention has been paid to incorporate the MASPS chip into the digital circuit board. The ultimate aim is to form a hybrid circuit used for mixed-signal processing, which can be applied to a micro sensor flow monitoring system. (semiconductor integrated circuits)

  9. Design and implementation of a hybrid circuit system for micro sensor signal processing*

    Institute of Scientific and Technical Information of China (English)

    Wang Zhuping; Chen Jing; Liu Ruqing

    2011-01-01

    This paper covers a micro sensor analog signal processing circuit system (MASPS) chip with low power and a digital signal processing circuit board implementation including hardware connection and software design.Attention has been paid to incorporate the MASPS chip into the digital circuit board. The ultimate aim is to form a hybrid circuit used for mixed-signal processing, which can be applied to a micro sensor flow monitoring system.

  10. Bio-hybrid micro/nanodevices powered by flagellar motor: challenges and strategies

    Directory of Open Access Journals (Sweden)

    Jin-Woo eKim

    2015-07-01

    Full Text Available Molecular motors, which are precision-engineered by nature, offer exciting possibilities for bio-hybrid engineered systems. They could enable real applications ranging from micro/nano fluidics, to biosensing, to medical diagnoses. This review describes the fundamental biological insights and fascinating potentials of these remarkable sensing and actuation machines, in particular bacterial flagellar motors, as well as their engineering perspectives with regard to applications in bio-engineered hybrid systems and nanobiotechnology.

  11. MODELISATION ET COMMANDE D'UN ALTERNO-DEMARREUR HEPTAPHASE POUR APPLICATION AUTOMOBILE MICRO-HYBRIDE

    OpenAIRE

    BRUYERE, Antoine

    2009-01-01

    This work deals with the study of a multiphase starter-alternator system, used for a micro-hybrid vehicle. This system is composed of a 7-phase claw-pole synchronous machine, with permanent magnets between the claws and fractional windings. It is supplied with a 7-leg Voltage Source Inverter (VSI).In the first chapter, states of the art are given, firstly, about hybrid technologies in Automotive, then, about multiphase machines modeling methodologies, aiming at their control. A specific model...

  12. Motion-free hybrid design laser beam propagation analyzer using a digital micromirror device and a variable focus liquid lens.

    Science.gov (United States)

    Sheikh, Mumtaz; Riza, Nabeel A

    2010-06-01

    To the best of our knowledge, we propose the first motion-free laser beam propagation analyzer with a hybrid design using a digital micromirror device (DMD) and a liquid electronically controlled variable focus lens (ECVFL). Unlike prior analyzers that require profiling the beam at multiple locations along the light propagation axis, the proposed analyzer profiles the beam at the same plane for multiple values of the ECVFL focal length, thus eliminating beam profiler assembly motion. In addition to measuring standard Gaussian beam parameters, the analyzer can also be used to measure the M(2) beam propagation parameter of a multimode beam. Proof-of-concept beam parameter measurements with the proposed analyzer are successfully conducted for a 633 nm laser beam. Given the all-digital nature of the DMD-based profiling and all-analog motion-free nature of the ECVFL beam focus control, the proposed analyzer versus prior art promises better repeatability, speed, and reliability.

  13. Performance evaluation of hybrid modified micro-channel solar cell ...

    African Journals Online (AJOL)

    user

    Keywords: Solar cell thermal tile, Micro-channel, Electrical efficiency, Thermal modeling. 1. ... than that of the PV modules is heated, while at the same time, the PV module ..... For a number of modified MCSCT tiles connected in series, the outlet ..... Group Technology, Neural Networks, and Non-traditional Optimization and.

  14. Bio-Inspired Wide-Angle Broad-Spectrum Cylindrical Lens Based on Reflections from Micro-Mirror Array on a Cylindrical Elastomeric Membrane

    Directory of Open Access Journals (Sweden)

    Chi-Chieh Huang

    2014-06-01

    Full Text Available We present a wide-angle, broad-spectrum cylindrical lens based on reflections from an array of three-dimensional, high-aspect-ratio micro-mirrors fabricated on a cylindrical elastomeric substrate, functionally inspired by natural reflecting superposition compound eyes. Our device can perform one-dimensional focusing and beam-shaping comparable to conventional refraction-based cylindrical lenses, while avoiding chromatic aberration. The focal length of our cylindrical lens is 1.035 mm, suitable for micro-optical systems. Moreover, it demonstrates a wide field of view of 152° without distortion, as well as modest spherical aberrations. Our work could be applied to diverse applications including laser diode collimation, barcode scanning, holography, digital projection display, microlens arrays, and optical microscopy.

  15. Issues regarding the modelling and simulation of hybrid micro grid systems

    Science.gov (United States)

    Szeidert, I.; Filip, I.; Prostean, O.

    2016-02-01

    The main followed objectives within control strategies dedicated to hybrid micro grid systems (wind/hydro/solar), that operate based on maximum power point tracking (MPPT) techniques are to improve the conversion systems efficiency and to maintain the quality of the produced electrical energy (the voltage and power factor control). One of the main goals of maximum power point tracking strategy is to achieve the harvesting of the maximal possible energy within a pre-set time period. In order to implement the control strategies for micro grid systems that operate at time variable parameter, there are usually required specific transducers (anemometer for wind speed measurement, optical rotational transducers, taco generators, etc.). In the technical literature there are presented several variants of the MPPT techniques, which are particularized at several applications (wind energy conversion systems, solar systems, hydro plants and micro grid hybrid systems). The maximum power point tracking implementations are mainly based on two-level architecture. The inferior level controls the primary variables, while the superior level represents the MPPT control structure. In the paper, authors present some micro grid structures proposed at Politehnica University Timisoara within the frame of a research grant. The paper is focused on the application of MPPT strategies on hybrid micro grid systems. There are presented several structures and control strategies and are highlighted their advantages and disadvantages, together with practical implementation guidelines.

  16. Aspherical lens design using hybrid neural-genetic algorithm of contact lenses.

    Science.gov (United States)

    Yen, Chih-Ta; Ye, Jhe-Wen

    2015-10-01

    The design of complex contact lenses involves numerous uncertain variables. How to help an optical designer to first design the optimal contact lens to reduce discomfort when wearing a pair of glasses is an essential design concern. This study examined the impact of aberrations on contact lenses to optimize a contact lens design for myopic and astigmatic eyes. In general, two aspherical surfaces can be assembled in an optical system to reduce the overall volume size. However, this design reduces the spherical aberration (SA) values at wide contact radii. The proposed optimization algorithm with optical design can be corrected to improve the SA value and, thus, reduce coma aberration (TCO) values and enhance the modulation transfer function (MTF). This means integrating a modified genetic algorithm (GA) with a neural network (NN) to optimize multiple-quality characteristics, namely the SA, TCO, and MTF, of contact lenses. When the proposed optional weight NN-GA is implemented, the weight values of the fitness function can be varied to adjust system performance. The method simplifies the selection of parameters in the optimization of optical systems. Compared with the traditional CODE V built-in optimal scheme, the proposed scheme is more flexible and intuitive to improve SA, TCO, and MTF values by 50.03%, 45.78%, and 24.7%, respectively.

  17. Clinical efficacy of micro incision phacoemulsification and intraocular lens implantation in patients with shallow anterior chamber and cataract

    Directory of Open Access Journals (Sweden)

    Xue-Feng Pan

    2016-06-01

    Full Text Available AIM: To investigate the efficacy and safety of phacoemulsification combined with intraocular lens implantation in the treatment of shallow anterior chamber with cataract. METHODS: Retrospective case series. From February 2014 to July 2015 in our hospital,65 eyes in 65 patients with cataract were enrolled and divided into mild and high risk of shallow anterior chamber group. Best-corrected visual acuity(BCVA, intraocular pressure(IOP, central anterior chamber dept(CACD, angle opening distance(AOD, complications pre- and post treatment, were observed and analyzed as outcome measures. RESULTS:In this study, the mild shallow anterior chamber group included 34 eyes; postoperative BCVA were improved in 29 eyes, with 4 eyes remaining stable and decreased in 1 eye; BCVA was improved in 16 eyes, with 10 eyes remaining stable and decreased in 5 eyes in high risk of shallow anterior chamber group postoperatively. BCVA had a better prognosis in the mild shallow anterior chamber group than another group(t=-2.956, Pt=-5.02,-3.04; PF=203.75, PCONCLUSION: Micro incision cataract surgery is useful, effective and safe in patients with cataract and shallow anterior chamber which can stabilize or improve BCVA, reduce IOP, deepen CACD and open the anterior chamber angle.

  18. Micro-Processes of Employees in a Hybrid Organization

    DEFF Research Database (Denmark)

    Svenningsen, Virginie; Boxenbaum, Eva; Ravasi, Davide

    actors engaged in the energy transition. We draw on the literature on institutional logics and hybrid organizations to examine how employees of this French energy corporation deal with this institutionally complex environment. Our findings point to three strategies that individuals use to cope......The present article examines how employees cope with an organizational setting that is institutionally complex. The empirical setting is a French energy corporation that simultaneously pursues a logic of science and a logic of market through multiple research partnerships with public and private...

  19. Hybridization kinetics analysis of an oligonucleotide microarray for microRNA detection

    Institute of Scientific and Technical Information of China (English)

    Botao Zhao; Shuo Ding; Wei Li; Youxin Jin

    2011-01-01

    MicroRNA (miRNA) microarrays have been successfully used for profiling miRNA expression in many physiological processes such as development, differentiation, oncogenesis,and other disease processes. Detecting miRNA by miRNA microarray is actually based on nucleic acid hybridization between target molecules and their corresponding complementary probes. Due to the small size and high degree of similarity among miRNA sequences, the hybridization condition must be carefully optimized to get specific and reliable signals. Previously, we reported a microarray platform to detect miRNA expression. In this study, we evaluated the sensitivity and specificity of our microarray platform. After systematic analysis, we determined an optimized hybridization condition with high sensitivity and specificity for miRNA detection. Our results would be helpful for other hybridization-based miRNA detection methods, such as northern blot and nuclease protection assay.

  20. Grid-connected Photovoltaic Micro-inverter with New Hybrid Control LLC Resonant Converter

    DEFF Research Database (Denmark)

    Xingkui, Mao; Qisheng, Huang; Qingbo, Ke;

    2016-01-01

    A high-efficiency photovoltaic (PV) micro-inverter consisting of two power stages i.e. a LLC resonant converter with a new hybrid control scheme and a dc-ac inverter is proposed, studied and designed in this paper. In the first power stage, the new hybrid control combining pulse-frequency modulat......A high-efficiency photovoltaic (PV) micro-inverter consisting of two power stages i.e. a LLC resonant converter with a new hybrid control scheme and a dc-ac inverter is proposed, studied and designed in this paper. In the first power stage, the new hybrid control combining pulse......-frequency modulation (PFM) and phase-shift pulse-width modulation (PS-PWM) is employed on a full-bridge LLC dc-dc converter, in order to achieve high efficiency when PV output voltage varies in a wide range. Moreover, a maximum power point tracking (MPPT) method based on power perturbation is implemented in the dc......-ac inverter. Therefore, the complexity of regulating LLC converter can be reduced effectively, and efficiency optimal design can be carried out through the proposed designing procedure for the resonant tank of LLC converter. Finally, a prototype of the proposed PV micro-inverter (PVMI) is developed with rated...

  1. Hybrid Energy System Design of Micro Hydro-PV-biogas Based Micro-grid

    Science.gov (United States)

    Nishrina; Abdullah, A. G.; Risdiyanto, A.; Nandiyanto, ABD

    2017-03-01

    Hybrid renewable energy system is an arrangement of one or more sources of renewable energy and also conventional energy. This paper describes a simulation results of hybrid renewable power system based on the available potential in an educational institution in Indonesia. HOMER software was used to simulate and analyse both in terms of optimization and economic terms. This software was developed through 3 main principles; simulation, optimization, and sensitivity analysis. Generally, the presented results show that the software can demonstrate a feasible hybrid power system as well to be realized. The entire demand in case study area can be supplied by the system configuration and can be met by ¾ of electricity production. So, there are ¼ of generated energy became an excess electricity.

  2. Fluorescence In Situ Hybridization for MicroRNA Detection in Archived Oral Cancer Tissues

    Directory of Open Access Journals (Sweden)

    Zonggao Shi

    2012-01-01

    Full Text Available The noncoding RNA designated as microRNA (miRNA is a large group of small single-stranded regulatory RNA and has generated wide-spread interest in human disease studies. To facilitate delineating the role of microRNAs in cancer pathology, we sought to explore the feasibility of detecting microRNA expression in formalin-fixed paraffin-embedded (FFPE tissues. Using FFPE materials, we have compared fluorescent in situ hybridization (FISH procedures to detect miR-146a with (a different synthetic probes: regular custom DNA oligonucleotides versus locked nucleic acid (LNA incorporated DNA oligonucleotides; (b different reporters for the probes: biotin versus digoxigenin (DIG; (c different visualization: traditional versus tyramide signal amplification (TSA system; (d different blocking reagents for endogenous peroxidase. Finally, we performed miR-146a FISH on a commercially available oral cancer tissue microarray, which contains 40 cases of oral squamous cell carcinoma (OSCC and 10 cases of normal epithelia from the human oral cavity. A sample FISH protocol for detecting miR-146a is provided. In summary, we have established reliable in situ hybridization procedures for detecting the expression of microRNA in FFPE oral cancer tissues. This method is an important tool for studies on the involvement of microRNA in oral cancer pathology and may have potential prognostic or diagnostic value.

  3. Piezoelectric properties of the new generation active matrix hybrid (micro-nano) composites

    Science.gov (United States)

    Parali, Levent; Şabikoğlu, İsrafil; Kurbanov, Mirza A.

    2014-11-01

    A hybrid piezoelectric composite structure is obtained by addition of nano-sized BaTiO3, SiO2 to the micro-sized PZT and polymers composition. Although the PZT material itself has excellent piezoelectric properties, PZT-based composite variety is limited. Piezoelectric properties of PZT materials can be varied with an acceptor or a donor added to the material. In addition, varieties of PZT-based sensors can be increased with doping polymers which have physical-mechanical, electrophysical, thermophysical and photoelectrical properties. The active matrix hybrid structure occurs when bringing together the unique piezoelectric properties of micro-sized PZT with electron trapping properties of nano-sized insulators (BaTiO3 or SiO2), and their piezoelectric, mechanic and electromechanic properties significantly change. In this study, the relationship between the piezoelectric constant and the coupling factor values of microstructure (PZT-PVDF) and the hybrid structure (PZT-PVDF-BaTiO3) composite are compared. The d33 value and the coupling factor of the hybrid structure have shown an average of 54 and 62% increase according to microstructure composite, respectively. In addition, the d33 value and the coupling factor of the hybrid structure (PZT-HDPE-SiO2) have exhibited about 68 and 52% increase according to microstructure composite (PZT-HDPE), respectively.

  4. Hybrid isolation of micro vibrations induced by reaction wheels

    Science.gov (United States)

    Lee, Dae-Oen; Park, Geeyong; Han, Jae-Hung

    2016-02-01

    As the technology for precision satellite payloads continues to advance, the requirements for the pointing stability of the satellites are becoming extremely high. In many situations, even small amplitude disturbances generated by the onboard components may cause serious degradation in the performance of high precision payloads. In such situations, vibration isolators can be installed to reduce the vibration transmission. In this work, a hybrid vibration isolator comprising passive and active components is proposed to provide an effective solution to the vibration problems caused by the reaction wheel disturbances. Firstly, mathematical modeling and experimental study of a single axis vibration isolator having high damping and high roll-off rate for the high frequency region and active components that enhance isolation performance for narrow frequency bands are presented. This concept is then extended to multi-axis by forming Stewart platform and the performance is experimentally verified. The tests on a flexible testbed show effective vibration isolation by the proposed vibration isolator.

  5. [Lens platform].

    Science.gov (United States)

    Łukaszewska-Smyk, Agnieszka; Kałuzny, Józef

    2010-01-01

    The lens platform defines lens structure and lens material. Evolution of lens comprises change in their shape, angulation of haptens and transition of three-piece lens into one-piece lens. The lens fall into two categories: rigid (PMMA) and soft (siliconic, acrylic, colameric). The main lens maaterials are polymers (hydrophilic and hydrophobic). The lens platform has an effect on biocompatibility, bioadhesion, stability of lens in capsule, degree of PCO evolution and sensitiveness to laser damages.

  6. Grid-connected Photovoltaic Micro-inverter with New Hybrid Control LLC Resonant Converter

    DEFF Research Database (Denmark)

    Xingkui, Mao; Qisheng, Huang; Qingbo, Ke;

    2016-01-01

    A high-efficiency photovoltaic (PV) micro-inverter consisting of two power stages i.e. a LLC resonant converter with a new hybrid control scheme and a dc-ac inverter is proposed, studied and designed in this paper. In the first power stage, the new hybrid control combining pulse...... power of 250W and output voltage of 220VAC/50Hz. The experiment shows that the peak efficiency of the PVMI is 95.5%, where efficiency of LLC converter is up to 97.7%, and the MPPT accuracy is more than 99%. Thus the validity of the proposed system structure, design and control method is verified....

  7. Mathematical Modelling of a Hybrid Micro-Cogeneration Group Based on a Four Stroke Diesel Engine

    Directory of Open Access Journals (Sweden)

    Apostol Valentin

    2014-06-01

    Full Text Available The paper presents a part of the work conducted in the first stage of a Research Grant called ”Hybrid micro-cogeneration group of high efficiency equipped with an electronically assisted ORC” acronym GRUCOHYB. The hybrid micro-cogeneration group is equipped with a four stroke Diesel engine having a maximum power of 40 kW. A mathematical model of the internal combustion engine is presented. The mathematical model is developed based on the Laws of Thermodynamics and takes into account the real, irreversible processes. Based on the mathematical model a computation program was developed. The results obtained were compared with those provided by the Diesel engine manufacturer. Results show a very high correlation between the manufacturer’s data and the simulation results for an engine running at 100% load. Future developments could involve using an exergetic analysis to show the ability of the ORC to generate electricity from recovered heat

  8. Contact lens in keratoconus

    OpenAIRE

    Varsha M Rathi; Preeji S Mandathara; Srikanth Dumpati

    2013-01-01

    Contact lenses are required for the visual improvement in patients with keratoconus. Various contact lens options, such as rigid gas permeable (RGP) lenses, soft and soft toric lenses, piggy back contact lenses (PBCL), hybrid lenses and scleral lenses are availble. This article discusses about selection of a lens depending on the type of keratoconus and the fitting philosophies of various contact lenses including the starting trial lens. A Medline search was carried out for articles in the En...

  9. Experimental investigation on thermoelectric generator of micro hybrid power source

    Science.gov (United States)

    Shang, Yonghong; Li, Yanqiu; Yu, Hongyun; Sun, Hongguang; Su, Bo

    2007-12-01

    The micro power system, which is composed of photovoltaic solar cell, heat conductor, thermoelectric generator (TEG) module and fin heat sink has been developed in our laboratory. A photovoltaic silicon solar cell of the P-N junction type is sensitive to radiant energy of wavelength from 5,000 Å to 12,000 Å. Radiation under and within this range is converted not only into electric energy but also into heat energy. The wavelength longer than this range is also converted into heat energy, which degrades the conversion efficiency of the solar cell. TEG produces electrical power from temperature difference via Seebeck effect that can be put under the solar cell to absorb the heat. The heat energy can be converted into electrical power. It was found that when TEG surface area was 150mm×60mm, it could generate 0.24V output voltage and 4.18mA short circuit at ambient temperature varying between 5-10°C at winter. It also could generate 1.3V output voltage and 16mA short circuit at ambient temperature varying between 30-36°C at summer. In fact we can use a dc-dc boost up converter to enlarge the output voltage to meet the requirements of wireless sensor network nodes or its recharging battery. It will be an alternative power source for many portable electronic types of equipment.

  10. Reactive power control of wind-diesel-micro-hydro hybrid power systems using matlab/simulink

    Energy Technology Data Exchange (ETDEWEB)

    Bansal, R.C.; Bhatti, T.S.; Kothari, D.P.; Bhat, S. [Birla Inst. of Technology and Science, Pilani (India); Indian Inst. of Technology, New Delhi (India). Centre for Energy Studies; Visvesvaraya National Inst. of Technology, Nagpur (IN). Dept. of Electrical Engineering)

    2005-07-01

    This paper presents reactive power control of isolated wind-diesel-micro-hydro hybrid power system for realistic load disturbance using matlab/simulink. The mathematical model of the system based on matlab/simulink is developed. Reactive power control performance is compared using three different types of Static VAR Compensators (SVC). Transient responses for step plus normally distributed or band limited white noise random change in load have also been presented in this paper. (Author)

  11. Extension of hybrid micro-depletion model for decay heat calculation in the DYN3D code

    Energy Technology Data Exchange (ETDEWEB)

    Bilodid, Yurii; Fridman, Emil [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Reactor Safety; Kotlyar, D. [Georgia Institute of Technology, Atlanta, GA (United States); Shwageraus, E. [Cambridge Univ. (United Kingdom)

    2017-06-01

    This work extends the hybrid micro-depletion methodology, recently implemented in DYN3D, to the decay heat calculation by accounting explicitly for the heat contribution from the decay of each nuclide in the fuel.

  12. Hybrid microcircuit metallization system for the SLL micro actuator

    Energy Technology Data Exchange (ETDEWEB)

    Hampy, R. E.; Knauss, G. L.; Komarek, E. E.; Kramer, D. K.; Villaueva, J.

    1976-03-01

    A thin film technique developed for the SLL Micro Actuator in which both gold and aluminum can be incorporated on sapphire or fine grained alumina substrates in a two-level metallization system is described. Tungsten is used as a lateral transition metal permitting electrical contact between the gold and aluminum without the two metals coming in physical contact. Silicon dioxide serves as an insulator between the tungsten and aluminum for crossover purposes, and vias through the silicon dioxide permit interconnections where desired. Tungsten-gold is the first level conductor except at crossovers where tungsten only is used and aluminum is the second level conductor. Sheet resistances of the two levels can be as low as 0.01 ohm/square. Line widths and spaces as small as 0.025 mm can be attained. A second layer of silicon dioxide is deposited over the metallization and opened for all gold and aluminum bonding areas. The metallization system permits effective interconnection of a mixture of devices having both gold and aluminum terminations without creating undesirable gold-aluminum interfaces. Processing temperatures up to 400/sup 0/C can be tolerated for short times without effect on bondability, conductor, and insulator characteristics, thus permitting silicon-gold eutectic die attachment, component soldering, and higher temperatures during gold lead bonding. Tests conducted on special test pattern circuits indicate good stability over the temperature range -55 to +150/sup 0/C. Aging studies indicate no degradation in characteristics in tests of 500 h duration at 150/sup 0/C.

  13. High-efficiency thin and compact concentrator photovoltaics using micro-solar cells with via-holes sandwiched between thin lens-array and circuit board

    Science.gov (United States)

    Itou, Akihiro; Asano, Tetsuya; Inoue, Daijiro; Arase, Hidekazu; Matsushita, Akio; Hayashi, Nobuhiko; Futakuchi, Ryutaro; Inoue, Kazuo; Yamamoto, Masaki; Fujii, Eiji; Nakagawa, Tohru; Anda, Yoshiharu; Ishida, Hidetoshi; Ueda, Tetsuzo; Fidaner, Onur; Wiemer, Michael; Ueda, Daisuke

    2014-01-01

    We have developed a compact concentrator photovoltaic (CPV) module that comprises micro-solar cells with an area of ≈0.6 × 0.6 mm2 sandwiched between a 20-mm-thick lens array and a 1-mm-thick circuit board with no air gap. To establish electrical connections between the circuit board and the micro-solar cells, we developed a micro-solar cell with positive and negative electrodes on the lower face of the cell. In this study, we demonstrated the photovoltaic performance of the micro-solar cell closely approaches that of the standard solar cell measuring ≈5 × 5 mm2 commonly used in conventional CPVs under concentrated illumination. Our study showed that the negative effect on PV performance of perimeter carrier recombination in the micro-solar cell was insignificant under concentrated illumination. Finally, we assembled our micro-solar cells into a CPV module and achieved the module energy conversion efficiency of 34.7% under outdoor solar illumination.

  14. Multiscale Hybrid Micro-Nanocomposites Based on Carbon Nanotubes and Carbon Fibers

    Directory of Open Access Journals (Sweden)

    Fawad Inam

    2010-01-01

    Full Text Available Amino-modified double wall carbon nanotube (DWCNT-NH2/carbon fiber (CF/epoxy hybrid micro-nanocomposite laminates were prepared by a resin infusion technique. DWCNT-NH2/epoxy nanocomposites and carbon fiber/epoxy microcomposites were made for comparison. Morphological analysis of the hybrid composites was performed using field emission scanning electron microscope. A good dispersion at low loadings of carbon nanotubes (CNTs in epoxy matrix was achieved by a bath ultrasonication method. Mechanical characterization of the hybrid micro-nanocomposites manufactured by a resin infusion process included three-point bending, mode I interlaminar toughness, dynamic mechanical analysis, and drop-weight impact testing. The addition of small amounts of CNTs (0.025, 0.05, and 0.1 wt% to epoxy resins for the fabrication of multiscale carbon fiber composites resulted in a maximum enhancement in flexural modulus by 35%, a 5% improvement in flexural strength, a 6% improvement in absorbed impact energy, and 23% decrease in the mode I interlaminar toughness. Hybridization of carbon fiber-reinforced epoxy using CNTs resulted in a reduction in and dampening characteristics, presumably as a result of the presence of micron-sized agglomerates.

  15. Direct writing of micro/nano-scale patterns by means of particle lens arrays scanned by a focused diode pumped Nd:YVO4 laser

    Science.gov (United States)

    Pena, Ana; Wang, Zengbo; Whitehead, David; Li, Lin

    2010-11-01

    A practical approach to a well-known technique of laser micro/nano-patterning by optical near fields is presented. It is based on surface patterning by scanning a Gaussian laser beam through a self-assembled monolayer of silica micro-spheres on a single-crystalline silicon (Si) substrate. So far, the outcome of this kind of near-field patterning has been related to the simultaneous, parallel surface-structuring of large areas either by top hat or Gaussian laser intensity distributions. We attempt to explore the possibility of using the same technique in order to produce single, direct writing of features. This could be of advantage for applications in which only some areas need to be patterned (i.e. local area selective patterning) or single lines are required (e.g. a particular micro/nano-fluidic channel). A diode pumped Nd:YVO4 laser system (wavelength of 532 nm, pulse duration of 8 ns, repetition rate of 30 kHz) with a computer-controlled 3 axis galvanometer beam scanner was employed to write user-defined patterns through the particle lens array on the Si substrate. After laser irradiation, the obtained patterns which are in the micro-scale were composed of sub-micro/micro-holes or bumps. The micro-pattern resolution depends on the dimension of both the micro-sphere’s diameter and the beam’s spot size. The developed technique could potentially be employed to fabricate photonic crystal structures mimicking nature’s butterfly wings and anti-reflective “moth eye” arrays for photovoltaic cells.

  16. 17.6%-Efficient radial junction solar cells using silicon nano/micro hybrid structures

    Science.gov (United States)

    Lee, Kangmin; Hwang, Inchan; Kim, Namwoo; Choi, Deokjae; Um, Han-Don; Kim, Seungchul; Seo, Kwanyong

    2016-07-01

    We developed a unique nano- and microwire hybrid structure by selectively modifying only the tops of microwires using metal-assisted chemical etching. The proposed nano/micro hybrid structure not only minimizes surface recombination but also absorbs 97% of incident light under AM 1.5G illumination, demonstrating outstanding light absorption compared to that of planar (59%) and microwire arrays (85%). The proposed hybrid solar cells with an area of 1 cm2 exhibit power conversion efficiencies (Eff) of up to 17.6% under AM 1.5G illumination. In particular, the solar cells show a high short-circuit current density (Jsc) of 39.5 mA cm-2 because of the high light-absorbing characteristics of the nanostructures. This corresponds to an approximately 61.5% and 16.5% increase in efficiency compared to that of a planar silicon solar cell (Eff = 10.9%) and a microwire solar cell (Eff = 15.1%), respectively. Therefore, we expect the proposed hybrid structure to become a foundational technology for the development of highly efficient radial junction solar cells.We developed a unique nano- and microwire hybrid structure by selectively modifying only the tops of microwires using metal-assisted chemical etching. The proposed nano/micro hybrid structure not only minimizes surface recombination but also absorbs 97% of incident light under AM 1.5G illumination, demonstrating outstanding light absorption compared to that of planar (59%) and microwire arrays (85%). The proposed hybrid solar cells with an area of 1 cm2 exhibit power conversion efficiencies (Eff) of up to 17.6% under AM 1.5G illumination. In particular, the solar cells show a high short-circuit current density (Jsc) of 39.5 mA cm-2 because of the high light-absorbing characteristics of the nanostructures. This corresponds to an approximately 61.5% and 16.5% increase in efficiency compared to that of a planar silicon solar cell (Eff = 10.9%) and a microwire solar cell (Eff = 15.1%), respectively. Therefore, we expect the

  17. On hydrophilicity improvement of the porous anodic alumina film by hybrid nano/micro structuring

    Science.gov (United States)

    Wang, Weichao; Zhao, Wei; Wang, Kaige; Wang, Lei; Wang, Xuewen; Wang, Shuang; Zhang, Chen; Bai, Jintao

    2017-09-01

    In both, laboratory and industry, tremendous attention is paid to discover an effective technique to produce uniform, controllable and (super) hydrophilic surfaces over large areas that are useful in a wide range of applications. In this investigation, by combing porous anodic alumina (PAA) film with nano-structures and microarray of aluminum, the hydrophilicity of hybrid nano-micro structure has been significantly improved. It is found some factors can affect the hydrophilicity of film, such as the size and aspect ratio of microarray, the thickness of nano-PAA film etc. Comparing with pure nano-PAA films and microarray, the hybrid nano-micro structure can provide uniform surface with significantly better hydrophilicity. The improvement can be up to 84%. Also, this technique exhibits good stability and repeatability for industrial production. By optimizing the thickness of nano-PAA film and aspect ratio of micro-structures, super-hydrophilicity can be reached. This study has obvious prospect in the fields of chemical industry, biomedical engineering and lab-on-a-chip applications.

  18. Effect of Light Direction on the Microleakage of Micro Filled and Hybrid Resin Composites

    Directory of Open Access Journals (Sweden)

    A Davari

    2010-11-01

    Full Text Available Introduction: One of the most important factors affecting the marginal seal of composite restorations is polymerization shrinkage. The aim of this study was to evaluate the micro leakage of two resin composites cured with two light directions. Methods: In this experimental study, forty similar class III preparations were prepared in 40 human anterior teeth. The teeth were randomly divided in two groups according to the resin composite used for filling the cavities (Microfilled composite: Heliomolar or hybrid composite: Spectrum. Etch group was further divided in two subgroups according to the light direction buccal and lingual. All the cavities were filled with the composites and cured for 40 seconds. The teeth were then thermocycled for 500 cycles between 5-55°c and covered with nail polish except for 1mm around cavity margins and immersed in 1% methylene blue for 12 hours. The teeth were sectioned and the dye penetration scores were recorded using stereo microscope. Data was analyzed using non parametric Mann Whitney test. Results: No significant difference was observed between the composite resins (p>0.05 or the light directions used for curing the composite resins (p>0.05. Conclusion: Directions of the light does not have any effect on the micro leakage of hybrid or micro filled composites in class III cavities.

  19. Nano- and micro-structured silicon for hybrid near-infrared photodetectors

    Science.gov (United States)

    Äńerek, V.; Głowacki, E. D.; Bednorz, M.; Demchyshyn, S.; Sariciftci, N. S.; Ivanda, M.

    2016-05-01

    Structuring surface and bulk of crystalline silicon on different length scales can significantly alter its properties and possibly improve the performance of opto-electronic devices and sensors based on silicon. Different dominant feature scales are responsible for modification of some of electronic and optical properties of silicon. Several easily reproducible chemical methods for facile structuring of silicon on nano and micro-scales, based on both electroless and anodic etching of silicon in hydrofluoric acid based etchants, and chemical anisotropic etching of silicon in basic environments, are presented. We show how successive micro and nano structuring creates hierarchical silicon surfaces, which can be used to simultaneously exploit the advantages of both structuring feature length scales. Finally, we demonstrate a large increase in photocurrent obtained from a hybrid structured silicon/organic near-infrared photodetector. Improved silicon/6,6'-dibromoindigo hybrid photodiodes were prepared by nano- and micro-structuring the silicon part of the heterojunction by wet chemical etching methods. Photocurrent and spectral responsivity were improved in comparison to planar diodes by up to two orders of magnitude by optimization of the silicon structuring process. We show that the improvement in photocurrent is not due to the increase in surface area or light trapping.

  20. Selected Parameters of Micro-Jet Cooling Gases in Hybrid Spraying Process

    Directory of Open Access Journals (Sweden)

    Szczucka-Lasota B.

    2016-06-01

    Full Text Available The innovative technology, like thermal spraying with a micro-jet cooling is one of the important modification of classical ultrasonic spraying methods. Using of micro-stream with gases like argon or nitrogen allows to cool the coating immediately after spraying, and thereby reduce the time of transition during the injection of each layer. As a result of the process, the fine dispersive structure of coatings is obtained during the shorter time in comparable to the classical high velocity oxygen fuel process (HVOF. The parameter of process and the type of stream equipment determine the quality of the obtained structure and thermal stress in the coating. The article presents the relationship between selected parameters of hybrid process and properties of the coatings. The presented technology should be adapted to the actual production of protective coating for machines and construction working in wear conditions.

  1. Dynamic Characteristics of PEM-FC/Woody Biomass Engine Hybrid Micro Grid

    Science.gov (United States)

    Obara, Shin'ya; Kito, Shunsuke; Hoshi, Akira; Sasaki, Seizi

    The combustion exhaust heat of woody biomass engine using Stirling cycle is high temperature. This exhaust heat is used for the city gas reforming reaction of a proton exchange membrane fuel cell (PEM-FC) system. The woody biomass engine generator has the characteristic that the greenhouse gas amount of emission with power generation is greatly reducible. In this paper, the micro grid system that introduces PEM-FC/woody biomass engine hybrid cogeneration (PWHC) is proposed. It depends on the dynamic characteristics of the grid for the power quality at the time of load fluctuation being added to the micro grid. Especially, the dynamic characteristics of the independent micro grid are important on security of power quality. So, in this paper, the response characteristic of PEM-FC and woody biomass engine was investigated by the experiment and the numerical analysis. Furthermore, the response characteristic of the PWHC independent micro grid including auxiliary machinery was investigated by the numerical simulation. Moreover, an improvement of dynamic characteristics is proposed using the method of adding proportional-plus-integral control to PWHC. If woody biomass engine is introduced into a house, 10.2s will be required to stabilize power quality at the maximum. On the other hand, when woody biomass engine corresponds to a base load and PEM-FC corresponds to the load exceeding the base load, settling time is less than 1.6 s. In this study, relation between the system configuration of the PWHC micro grid and the dynamic characteristics of the power was clarified.

  2. Hybrid Micro-Electro-Mechanical Systems for Highly Reliable and Selective Characterization of Tank Waste

    Energy Technology Data Exchange (ETDEWEB)

    Panos G. Datskos; Michael J. Sepaniak; Nickolay Lavrik; Pampa Dutta; Mustafa Culha

    2005-12-28

    The main objective of this research program is to develop robust and reliable micro-electro-mechanical sensing systems, based on microcantilevers (MCs), that can operate in liquid environments with high levels of sensitivity and selectivity. The chemical responses of MCs result from analyte-induced differential stress at the cantilever surfaces. We aim to employ various surface nanostructuring strategies that enhance these stresses and hence the degree of static bending of the cantilevers. Receptor phases as self assembled monolayers (SAMs) and thin films are being synthesized and tested to provide selectivity. Selectivity is chemically enhanced by using different phases on individual MCs in arrays and by adding a spectroscopic component, surface enhanced Raman spectrometry (SERS), in hybrid approaches to sensing. Significant progress was made in tasks that were listed in the work plan for DOE EMSP project ''Hybrid Micro-Electro-Mechanical Systems for Highly Reliable and Selective Characterization of Tank Waste''. Several project areas are listed below and discussed and referenced to our literature on the topics.

  3. Hybrid noise control in a duct using a light micro-perforated plate.

    Science.gov (United States)

    Wang, X N; Choy, Y S; Cheng, L

    2012-12-01

    A plate silencer consists of an expansion chamber with two side-branch cavities covered by light but extremely stiff plates. It works effectively with a wide stopband from low-to-medium frequencies only if the plate is extremely stiff, to ensure a strong reflection of acoustic wave to the upstream in the duct. However, a plate with a slightly weak bending stiffness will result in non-uniform transmission loss (TL) spectra with narrowed stopband. In this study, a hybrid silencer is proposed by introducing micro-perforations into the plate to elicit the sound absorption in order to compensate for the deficiency in the passband caused by the insufficient sound reflection in a certain frequency range due to weaker plate stiffness. A theoretical model, capable of dealing with the strong coupling between the vibrating micro-perforated plate and sound fields inside the cavity and the duct, is developed. Through proper balancing between the sound absorption and reflection, the proposed hybrid silencer provides a more flattened and uniform TL and a widened stopband by more than 20% while relaxing the harsh requirement on the bending stiffness of the plate. Theoretical predictions are validated by experimental data, with phenomenon explained through numerical analyses.

  4. Characteristic evaluation of Al2O3/CNTs hybrid materials for micro-electrical discharge machining

    Institute of Scientific and Technical Information of China (English)

    Hyun-Seok TAK; Chang-Seung HA; Ho-Jun LEE; Hyung-Woo LEE; Young-Keun JEONG; Myung-Chang KANG

    2011-01-01

    The characteristic evaluation of aluminum oxide (Al2O3)/carbon nanotubes (CNTs) hybrid composites for micro-electrical discharge machining (EDM) was described. Alumina matrix composites reinforced with CNTs were fabricated by a catalytic chemical vapor deposition method. Al2O3 composites with different CNT concentrations were synthesized. The electrical characteristic of Al2O3/CNTs composites was examined. These composites were machined by the EDM process according to the various EDM parameters, and the characteristics of machining were analyzed using field emission scanning electron microscope (FESEM). The electrical conductivity has a increasing tendency as the CNTs content is increased and has a critical point at 5% Al2O3 (volume fraction). In the machining accuracy, many tangles of CNT in Al2O3/CNTs composites cause violent spark. Thus, it causes the poor dimensional accuracy and circularity. The results show that conductivity of the materials and homogeneous distribution of CNTs in the matrix are important factors for micro-EDM of Al2O3/CNTs hybrid composites.

  5. Modeling wall effects in a micro-scale shock tube using hybrid MD-DSMC algorithm

    Science.gov (United States)

    Watvisave, D. S.; Puranik, B. P.; Bhandarkar, U. V.

    2016-07-01

    Wall effects in a micro-scale shock tube are investigated using the Direct Simulation Monte Carlo method as well as a hybrid Molecular Dynamics-Direct Simulation Monte Carlo algorithm. In the Direct Simulation Monte Carlo simulations, the Cercignani-Lampis-Lord model of gas-surface interactions is employed to incorporate the wall effects, and it is shown that the shock attenuation is significantly affected by the choice of the values of tangential momentum accommodation coefficient. A loosely coupled Molecular Dynamics-Direct Simulation Monte Carlo approach is then employed to demonstrate incomplete accommodation in micro-scale shock tube flows. This approach uses fixed values of the accommodation coefficients in the gas-surface interaction model, with their values determined from a separate dynamically similar Molecular Dynamics simulation. Finally, a completely coupled Molecular Dynamics-Direct Simulation Monte Carlo algorithm is used, wherein the bulk of the flow is modeled using Direct Simulation Monte Carlo, while the interaction of gas molecules with the shock tube walls is modeled using Molecular Dynamics. The two regions are separate and coupled both ways using buffer zones and a bootstrap coupling algorithm that accounts for the mismatch of the number of molecules in both regions. It is shown that the hybrid method captures the effect of local properties that cannot be captured using a single value of accommodation coefficient for the entire domain.

  6. Hybrid Micro-Electro-Mechanical Systems for Highly Reliable and Selective Characterization of Tank Waste

    Energy Technology Data Exchange (ETDEWEB)

    Panos G. Datskos; Michael J. Sepaniak; Nickolay Lavrik; Pampa Dutta; Mustafa Culha

    2005-12-28

    The main objective of this research program is to develop robust and reliable micro-electro-mechanical sensing systems, based on microcantilevers (MCs), that can operate in liquid environments with high levels of sensitivity and selectivity. The chemical responses of MCs result from analyte-induced differential stress at the cantilever surfaces. We aim to employ various surface nanostructuring strategies that enhance these stresses and hence the degree of static bending of the cantilevers. Receptor phases as self assembled monolayers (SAMs) and thin films are being synthesized and tested to provide selectivity. Selectivity is chemically enhanced by using different phases on individual MCs in arrays and by adding a spectroscopic component, surface enhanced Raman spectrometry (SERS), in hybrid approaches to sensing. Significant progress was made in tasks that were listed in the work plan for DOE EMSP project ''Hybrid Micro-Electro-Mechanical Systems for Highly Reliable and Selective Characterization of Tank Waste''. Several project areas are listed below and discussed and referenced to our literature on the topics.

  7. Fabrication of Nano-Micro Hybrid Structures by Replication and Surface Treatment of Nanowires

    Directory of Open Access Journals (Sweden)

    Yeonho Jeong

    2017-07-01

    Full Text Available Nanowire structures have attracted attention in various fields, since new characteristics could be acquired in minute regions. Especially, Anodic Aluminum Oxide (AAO is widely used in the fabrication of nanostructures, which has many nanosized pores and well-organized nano pattern. Using AAO as a template for replication, nanowires with a very high aspect ratio can be fabricated. Herein, we propose a facile method to fabricate a nano-micro hybrid structure using nanowires replicated from AAO, and surface treatment. A polymer resin was coated between Polyethylene terephthalate (PET and the AAO filter, roller pressed, and UV-cured. After the removal of aluminum by using NaOH solution, the nanowires aggregated to form a micropattern. The resulting structure was subjected to various surface treatments to investigate the surface behavior and wettability. As opposed to reported data, UV-ozone treatment can enhance surface hydrophobicity because the UV energy affects the nanowire surface, thus altering the shape of the aggregated nanowires. The hydrophobicity of the surface could be further improved by octadecyltrichlorosilane (OTS coating immediately after UV-ozone treatment. We thus demonstrated that the nano-micro hybrid structure could be formed in the middle of nanowire replication, and then, the shape and surface characteristics could be controlled by surface treatment.

  8. CO2 laser-micro plasma arc hybrid welding for galvanized steel sheets

    Institute of Scientific and Technical Information of China (English)

    C. H. KIM; Y. N. AHN; J. H. KIM

    2011-01-01

    A laser lap welding process for zinc-coated steel has a well-known unsolved problem-porosity formation. The boiling temperature of coated zinc is lower than the melting temperature of the base metal. which is steel. In the autogenous laser welding,the zinc vapor generates from the lapped surfaces expels the molten pool and the expulsion causes numerous weld defects, such as spatters and blow holes on the weld surface and porosity inside the welds. The laser-arc hybrid welding was suggested as an alternative method for the laser lap welding because the arc can preheat or post-heat the weldment according to the arrangement of the laser beam and the arc. CO2 laser-micro plasma hybrid welding was applied to the lap welding of zinc-coated steel with zero-gap.The relationships among the weld quality and process parameters of the laser-arc arrangement, and the laser-arc interspacing distance and arc current were investigated using a full-factorial experimental design. The effect of laser-arc arrangement is dominant because the leading plasma arc partially melts the upper steel sheets and vaporizes or oxidizes the coated zinc on the lapped surfaces.Compared with the result from the laser-TIG hybrid welding, the heat input from arc can be reduced by 40%.

  9. Hybrid micro-/nano-structures derived from metal-organic frameworks: preparation and applications in energy storage and conversion.

    Science.gov (United States)

    Cao, Xiehong; Tan, Chaoliang; Sindoro, Melinda; Zhang, Hua

    2017-05-22

    Metal-organic frameworks (MOFs), an important class of inorganic-organic hybrid crystals with intrinsic porous structures, can be used as versatile precursors or sacrificial templates for preparation of numerous functional nanomaterials for various applications. Recent developments of MOF-derived hybrid micro-/nano-structures, constructed by more than two components with varied functionalities, have revealed their extensive capabilities to overcome the weaknesses of the individual counterparts and thus give enhanced performance for energy storage and conversion. In this tutorial review, we summarize the recent advances in MOF-derived hybrid micro-/nano-structures. The synthetic strategies for preparing MOF-derived hybrid micro-/nano-structures are first introduced. Focusing on energy storage and conversion, we then discuss their potential applications in lithium-ion batteries, lithium-sulfur batteries, supercapacitors, lithium-oxygen batteries and fuel cells. Finally, we give our personal insights into the challenges and opportunities for the future research of MOF-derived hybrid micro-/nano-structures.

  10. An Efficient Hybrid DSMC/MD Algorithm for Accurate Modeling of Micro Gas Flows

    KAUST Repository

    Liang, Tengfei

    2013-01-01

    Aiming at simulating micro gas flows with accurate boundary conditions, an efficient hybrid algorithmis developed by combining themolecular dynamics (MD) method with the direct simulationMonte Carlo (DSMC)method. The efficiency comes from the fact that theMD method is applied only within the gas-wall interaction layer, characterized by the cut-off distance of the gas-solid interaction potential, to resolve accurately the gas-wall interaction process, while the DSMC method is employed in the remaining portion of the flow field to efficiently simulate rarefied gas transport outside the gas-wall interaction layer. A unique feature about the present scheme is that the coupling between the two methods is realized by matching the molecular velocity distribution function at the DSMC/MD interface, hence there is no need for one-toone mapping between a MD gas molecule and a DSMC simulation particle. Further improvement in efficiency is achieved by taking advantage of gas rarefaction inside the gas-wall interaction layer and by employing the "smart-wall model" proposed by Barisik et al. The developed hybrid algorithm is validated on two classical benchmarks namely 1-D Fourier thermal problem and Couette shear flow problem. Both the accuracy and efficiency of the hybrid algorithm are discussed. As an application, the hybrid algorithm is employed to simulate thermal transpiration coefficient in the free-molecule regime for a system with atomically smooth surface. Result is utilized to validate the coefficients calculated from the pure DSMC simulation with Maxwell and Cercignani-Lampis gas-wall interaction models. ©c 2014 Global-Science Press.

  11. Laser ablative decoration of micro-diamonds by gold nanoparticles for fabrication of hybrid plasmonic-dielectric antennae

    Science.gov (United States)

    Ivanova, A. K.; Ionin, A. A.; Khmelnitskii, R. A.; Kudryashov, S. I.; Levchenko, A. O.; Mel'nik, N. N.; Rudenko, A. A.; Saraeva, I. N.; Umanskaya, S. P.; Zayarny, D. A.; Nguyen, L. V.; Nguyen, T. T. H.; Pham, M. H.; Pham, D. V.; Do, T. H.

    2017-06-01

    Hybrid plasmonic-dielectric antennae are fabricated by laser ablation of gold in water sols of micro-diamonds. Electron microscopy and energy-dispersive x-ray spectroscopy of their deposits on a silicon wafer surface indicate close proximity of gold nanoparticles and micro-diamonds, which is supported by photoluminescence studies demonstrating strong (eight-fold) damping of micro-diamond luminescence owing to the attachment of the gold nanoparticles. UV-near-IR spectroscopy of their sols reveals a considerable plasmonic effect, related to red spectral shifts of surface plasmon resonance for the gold nanoparticles in the laser-ablation-fabricated antennae.

  12. Exergy analysis and optimization of a biomass gasification, solid oxide fuel cell and micro gas turbine hybrid system

    DEFF Research Database (Denmark)

    Bang-Møller, Christian; Rokni, Masoud; Elmegaard, Brian

    2011-01-01

    A hybrid plant producing combined heat and power (CHP) from biomass by use of a two-stage gasification concept, solid oxide fuel cells (SOFC) and a micro gas turbine was considered for optimization. The hybrid plant represents a sustainable and efficient alternative to conventional decentralized...... and exergy analyses were applied. Focus in this optimization study was heat management, and the optimization efforts resulted in a substantial gain of approximately 6% in the electrical efficiency of the plant. The optimized hybrid plant produced approximately 290 kWe at an electrical efficiency of 58...

  13. Ploidia e fertilidade de pólen em progênies de citros Ploidy and pollen fertility in citrus hybrids

    Directory of Open Access Journals (Sweden)

    Eduardo Cesar Brugnara

    2008-01-01

    Full Text Available Este trabalho foi desenvolvido para estimar a fertilidade do pólen e determinar o nível de ploidia em progênies dos cruzamentos da tangerineira 'Montenegrina' (C. deliciosa Ten. com a tangerineira 'King' (C. nobilis Lour. e com a laranjeira 'Caipira' (C. sinensis (L. Osb.. As plantas, de pés-francos e com idade entre 11 e 12 anos, são mantidas na Estação Experimental Agronômica da Universidade Federal do Rio Grande do Sul, em Eldorado do Sul. Avaliaram-se o nível de ploidia, através da contagem dos cromossomos em células em meiose, e a fertilidade do pólen, por coloração do pólen com carmim propiônico, em 2005 e 2006. Todos os híbridos avaliados são diplóides e a fertilidade de pólen variou de zero a 98%. C27 - híbrido de 'Montenegrina' x 'Caipira' - revelou-se praticamente estéril, e a fertilidade de C21, do mesmo cruzamento, é de 10%. A menor fertilidade observada no cruzamento da 'Montenegrina' x 'King' foi de 42%.This work was performed to estimate pollen fertility and determinate the ploidy level of 11 to 12 years old progenies of crosses of 'Montenegrina' mandarin (Citrus deliciosa Ten. with 'King' mandarin (C. nobilis Lour. and with 'Caipira' sweet orange (C. sinensis (L. Osb. maintained at Estação Experimental Agronômica of UFRGS, in Eldorado do Sul, Brazil. The ploidy level was determined by chromosome countings in meiosis cells and pollen fertility evaluated by staining pollen grains with propionic carmine. All evaluated hybrids are diploid and pollen fertility varied from zero to 98%. C27, a hybrid 'Montenegrina' x 'Caipira', was found is sterile, and C21, from the same cross, showed 10 % fertility. The lowest observed fertility in the progeny 'Montenegrina' x 'King' was 42 %.

  14. A millisecond micro-RNA separation technique by a hybrid structure of nanopillars and nanoslits.

    Science.gov (United States)

    Wu, Qiong; Kaji, Noritada; Yasui, Takao; Rahong, Sakon; Yanagida, Takeshi; Kanai, Masaki; Nagashima, Kazuki; Tokeshi, Manabu; Kawai, Tomoji; Baba, Yoshinobu

    2017-03-08

    A millisecond micro-RNA separation of a mixture of total RNA and genomic DNA, extracted from cultured HeLa cells, was successfully achieved using a hybrid structure of nanopillars and nanoslits contained inside a microchannel. The nanopillars, 250-nm in diameter and 100-nm in height, were fabricated with a 750-nm space inside the nanoslits, which were 100-nm in height and 25-μm in width; the nanopillars were then applied as a new sieve matrix. This ultra-fast technique for the separation of miRNA can be an effective pretreatment for semiconductor nanopore DNA sequencing, which has an optimum reading speed of 1 base/ms to obtain effective signal-to-noise ratio and discriminate each base by ion or tunneling current during the passage of nucleic acids.

  15. A millisecond micro-RNA separation technique by a hybrid structure of nanopillars and nanoslits

    Science.gov (United States)

    Wu, Qiong; Kaji, Noritada; Yasui, Takao; Rahong, Sakon; Yanagida, Takeshi; Kanai, Masaki; Nagashima, Kazuki; Tokeshi, Manabu; Kawai, Tomoji; Baba, Yoshinobu

    2017-01-01

    A millisecond micro-RNA separation of a mixture of total RNA and genomic DNA, extracted from cultured HeLa cells, was successfully achieved using a hybrid structure of nanopillars and nanoslits contained inside a microchannel. The nanopillars, 250-nm in diameter and 100-nm in height, were fabricated with a 750-nm space inside the nanoslits, which were 100-nm in height and 25-μm in width; the nanopillars were then applied as a new sieve matrix. This ultra-fast technique for the separation of miRNA can be an effective pretreatment for semiconductor nanopore DNA sequencing, which has an optimum reading speed of 1 base/ms to obtain effective signal-to-noise ratio and discriminate each base by ion or tunneling current during the passage of nucleic acids. PMID:28272420

  16. Randomized controlled split-mouth clinical trial of direct laminate veneers with two micro-hybrid resin composites

    NARCIS (Netherlands)

    Gresnigt, Marco M. M.; Kalk, Warner; Ozcan, M.; Ozcan, Mutlu

    Objectives: This randomized, split-mouth clinical study evaluated the survival rate of direct laminate veneers made of two resin-composite materials. Methods: A total of 23 patients (mean age: 52.4 years old) received 96 direct composite laminate veneers using two micro-hybrid composites in

  17. Randomized controlled split-mouth clinical trial of direct laminate veneers with two micro-hybrid resin composites

    NARCIS (Netherlands)

    Gresnigt, Marco M. M.; Kalk, Warner; Ozcan, M.; Ozcan, Mutlu

    2012-01-01

    Objectives: This randomized, split-mouth clinical study evaluated the survival rate of direct laminate veneers made of two resin-composite materials. Methods: A total of 23 patients (mean age: 52.4 years old) received 96 direct composite laminate veneers using two micro-hybrid composites in combinat

  18. Navigation Aiding by a Hybrid Laser-Camera Motion Estimator for Micro Aerial Vehicles

    Directory of Open Access Journals (Sweden)

    Jamal Atman

    2016-09-01

    Full Text Available Micro Air Vehicles (MAVs equipped with various sensors are able to carry out autonomous flights. However, the self-localization of autonomous agents is mostly dependent on Global Navigation Satellite Systems (GNSS. In order to provide an accurate navigation solution in absence of GNSS signals, this article presents a hybrid sensor. The hybrid sensor is a deep integration of a monocular camera and a 2D laser rangefinder so that the motion of the MAV is estimated. This realization is expected to be more flexible in terms of environments compared to laser-scan-matching approaches. The estimated ego-motion is then integrated in the MAV’s navigation system. However, first, the knowledge about the pose between both sensors is obtained by proposing an improved calibration method. For both calibration and ego-motion estimation, 3D-to-2D correspondences are used and the Perspective-3-Point (P3P problem is solved. Moreover, the covariance estimation of the relative motion is presented. The experiments show very accurate calibration and navigation results.

  19. Cycle Analysis of Micro Gas Turbine-Molten Carbonate Fuel Cell Hybrid System

    Science.gov (United States)

    Kimijima, Shinji; Kasagi, Nobuhide

    A hybrid system based on a micro gas turbine (µGT) and a high-temperature fuel cell, i.e., molten carbonate fuel cell (MCFC) or solid oxide fuel cell (SOFC), is expected to achieve a much higher efficiency than conventional distributed power generation systems. In this study, a cycle analysis method and the performance evaluation of a µGT-MCFC hybrid system, of which the power output is 30kW, are investigated to clarify its feasibility. We developed a general design strategy in which a low fuel input to a combustor and higher MCFC operating temperature result in a high power generation efficiency. A high recuperator temperature effectiveness and a moderate steam-carbon ratio are the requirements for obtaining a high material strength in a turbine. In addition, by employing a combustor for complete oxidation of MCFC effluents without additional fuel input, i.e., a catalytic combustor, the power generation efficiency of a µGT-MCFC is achieved at over 60%(LHV).

  20. Navigation Aiding by a Hybrid Laser-Camera Motion Estimator for Micro Aerial Vehicles.

    Science.gov (United States)

    Atman, Jamal; Popp, Manuel; Ruppelt, Jan; Trommer, Gert F

    2016-09-16

    Micro Air Vehicles (MAVs) equipped with various sensors are able to carry out autonomous flights. However, the self-localization of autonomous agents is mostly dependent on Global Navigation Satellite Systems (GNSS). In order to provide an accurate navigation solution in absence of GNSS signals, this article presents a hybrid sensor. The hybrid sensor is a deep integration of a monocular camera and a 2D laser rangefinder so that the motion of the MAV is estimated. This realization is expected to be more flexible in terms of environments compared to laser-scan-matching approaches. The estimated ego-motion is then integrated in the MAV's navigation system. However, first, the knowledge about the pose between both sensors is obtained by proposing an improved calibration method. For both calibration and ego-motion estimation, 3D-to-2D correspondences are used and the Perspective-3-Point (P3P) problem is solved. Moreover, the covariance estimation of the relative motion is presented. The experiments show very accurate calibration and navigation results.

  1. Statistical Analysis of Yarn Feature Parameters in C/Epoxy Plain-Weave Composite Using Micro CT with High-Resolution Lens-Coupled Detector

    Science.gov (United States)

    Wang, Hao; Wang, Zhong-wei

    2016-08-01

    C/Epoxy plain-weave composite is difficult to clear imaging in Micro CT with flat panel detector due to the similar atomic numbers of component materials. To solve this problem, a new Micro CT equipment with high-resolution lens-coupled detector is used to reconstruct 3D images of C/Epoxy. Slice data correction with ellipse projection is used to acquire real yarn normal cross-section information. A reference period method suitable for plain-weave composite is then detailed to evaluate statistical properties of yarn feature parameters. In the process of determination of real extreme slices, dislocation phenomenon existed in the laminated composite is discovered. Several possible reasons caused this phenomenon are discussed. Systematic trends, standard deviations and correlation lengths of stochastic deviations with original and corrected data are evaluated respectively by the application of reference period method. The statistical results show that mean out-of-plane yarn waviness, semi-axes, cross-section area and aspect ratio exhibit periodic characteristics, and the maximum effect of slice data correction on all statistical properties of feature parameters is twist angle.

  2. Investigation of an optical method for determining the average radius of curvature of micro-optical lenticular lens arrays

    DEFF Research Database (Denmark)

    Iversen, Theis Faber Quist; Hanson, Steen Grüner; Kirkegaard, Peter

    2009-01-01

    Micro-optical elements are of great importance in areas of optoelectronics and information processing. Establishing fast, reliable methods for characterization and quality control of these elements is important in order to maintain the optical performance in a high volume production process. We i...

  3. Rheological Behavior of a Novel Organic-Inorganic Hybrid: Micro/Nano-Tin Fluorophosphate Glass-Polycarbonate.

    Science.gov (United States)

    Yang, Jing; Liu, Huiwen; Yu, Honglin; Zou, Xiaoxuan; Jing, Bo; Dai, Wenli

    2016-03-01

    The rheological behavior of a novel, binary organic-inorganic hybrid consisting of an ultra-low Tg tin fluorophosphate glass (Pglass) and polycarbonate (PC) was investigated using oscillatory rheometry. It was found that the complex viscosity of the hybrid showed Pglass content dependence. Under low Pglass content (10-30%), the complex viscosity of the hybrid was lower than that of pure PC. While the complex viscosity was dramatically increased and higher than that of pure PC with the content of Pglass above 30%. This phenomenon was particularly remarkable at low frequencies. Besides, with the addition of Pglass the hybrid material exhibited shear-thinning behavior and the shear-thinning characteristics became more obvious with the enhancement of the Pglass content, indicating the presence of nonlinear chemical and physical interactions between the hybrid components. Differential scanning calorimetry (DSC) measurements revealed that increasing the content of Pglass caused a decrease of the glass transition temperature (Tg) of the hybrids, suggesting that Pglass was acting as a macromolecular plasticizer for the PC. The microstructure of the Pglass in the hybrid material was characterized by scanning electron microscopy (SEM). The results showed that the Pglass were dispersed as micro- and nano-bead in the continuous phase of PC and the Pglass appeared aggregation partly with the increase of the Pglass content. This contribution was anticipated to be a guideline for the processing of this promising new class of hybrid materials.

  4. Design and Fabrication of the Micro Lens Array Based on SU- 8%基于SU-8的微透镜阵列的设计和制作

    Institute of Scientific and Technical Information of China (English)

    刘建林; 张斌珍; 崔敏; 张剑; 季长红

    2012-01-01

    Using SU- 8 as a structural material, the micro lens arrays with the primary optical axis parallel to the substrate were processed by UV light lithography process, especially inclined exposure technology, and the diameter of a single micro lens is about 500 μm. The exposure dosage, pre-baking time, post-baking time and development time for processing the lens were confirmed preliminarily, providing a reference for processing lens with different size. Micro lens arrays based on the processing method can obtain the focusing, reflection, diffraction, phase modulation and other control for the beam to finally realize functions such as photo switch, attenuation, sweep and image formation, providing convenient for other micro optical device integration, such as spectroscope and reflector. Meanwhile, the micro lens arrays can be integrated in the micro flow cytometry to make fluorescence detection of sample flow, which greatly improves the detection accuracy.%以SU-8作为结构材料,采用紫外光刻工艺,尤其以斜曝光工艺为主,加工出主光轴平行于衬底基片的微透镜阵列,单个微透镜的直径大约为500 μm.初步确定出加工此透镜所需要的曝光剂量、前烘时间、后烘时间和显影时间,为加工其他尺寸的透镜提供参考.基于此方法加工的微透镜阵列能够对光束进行聚焦、反射、衍射、相位调制等控制,从而可最终实现光开关、衰减、扫描和成像等功能,为其他微型光学器件,如分光镜和反射镜等的系统集成提供极大的便利.同时,此微透镜阵列也会被集成在微流细胞仪中用来对流式细胞仪中样本流做荧光检测,极大地提高了检测的精度.

  5. Fabrication of multi-scale micro-lens arrays on hydrophobic surfaces using a drop-on-demand droplet generator

    Science.gov (United States)

    Zhu, Xiaoyang; Zhu, Li; Chen, Hejuan; Yang, Mei; Zhang, Weiyi

    2015-03-01

    A simple method was demonstrated for the fabrication of multi-scale polymer microlenses (μ-lenses) and microlens arrays (MLAs) using a drop-on-demand (DOD) droplet generator. A ultraviolet (UV) curable polymer used as the ink was DOD printed on the hydrophobic surfaces with different wetting conditions and cured by a UV lamp. The high quality μ-lenses and MLAs with good geometrical uniformity were fabricated. The shapes of the μ-lenses and MLAs were controlled by the different surface wetting conditions, and these shape changes affected the optical properties of the μ-lenses and MLAs, such as the numerical aperture (NA), focal distance (f) and the f-number (f#). The surface roughness of the μ-lens was measured by a white light interferometer (VSI mode) and atomic force microscope (AFM) and proved satisfactory. The influences of the surface wetting conditions on imaging and light gathering characteristics of the MLAs were evaluated by an optical microscope.

  6. Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides.

    Science.gov (United States)

    Deo, Monika; Yu, Jenn-Yah; Chung, Kwan-Ho; Tippens, Melissa; Turner, David L

    2006-09-01

    We have developed an in situ hybridization procedure for the detection of microRNAs (miRNAs) in tissue sections from mouse embryos and adult organs. The method uses highly specific washing conditions for RNA oligonucleotide probes conjugated to a fluorescein hapten. We show that this method detects predominantly mature miRNAs rather than the miRNA precursors or primary transcripts. We have determined expression patterns for several miRNAs expressed in the developing and adult nervous system, including miR-124a, miR-9, miR-92, and miR-204. Whereas miR-124a is expressed in neurons, miR-9 is expressed in neural progenitors and some neurons, and miR-204 is expressed in the choroid plexus, retinal pigment epithelium, and ciliary body. miR-204 is located in an intron of the TRPM3 gene, and the TRPM3 mRNA is coexpressed with miR-204 in the choroid plexus. We also find that primary transcripts for miR-124a and miR-9 genes are expressed in patterns similar to their respective mature miRNAs. The ability to visualize expression of specific miRNAs in embryos and tissues should aid studies on miRNA function. Copyright 2006 Wiley-Liss, Inc.

  7. Review on Recent Development Micro Gas Turbine -Trigeneration System and Photovoltaic Based Hybrid Energy System

    Directory of Open Access Journals (Sweden)

    Chand MRR

    2016-01-01

    Full Text Available Research on distributed power generation as an alternative method to the conventional power generation system continue to be developed to improve its commercialization capabilities. The cogeneration system and trigeneration system are technological improved alternatives in distributed generation where they offer enhancement and reliability in term of efficiency, emission performances and economic benefits. However, it is more feasible to implement the trigeneration system for most commercial and domestic distributed generations as the cooling demand is deliberately high compared to heating demand especially in hot and humid climate locations. Moreover, micro gas turbine is observed to be a beneficial prime mover in cogeneration and trigeneration system based on several criteria such as ability on acquiring high heat to power ratio characteristic as well as lower greenhouse gas emission. On the other hand, the role photovoltaic in building integrated system provides opportunities for renewable energy system engagement in trigeneration based distributed generation systems. This paper emphasize on summarizing the research work perform on cogeneration system or trigeneration system in hybrid mode with photovoltaic. There are also preceding sections on overviewing the state of art of cogeneration system and the trigeneration system as well as photovoltaic technologies in power generation.

  8. Launch Vehicles Based on Advanced Hybrid Rocket Motors: An Enabling Technology for the Commercial Small and Micro Satellite Planetary Science

    Science.gov (United States)

    Karabeyoglu, Arif; Tuncer, Onur; Inalhan, Gokhan

    2016-07-01

    Mankind is relient on chemical propulsion systems for space access. Nevertheless, this has been a stagnant area in terms of technological development and the technology base has not changed much almost for the past forty years. This poses a vicious circle for launch applications such that high launch costs constrain the demand and low launch freqencies drive costs higher. This also has been a key limiting factor for small and micro satellites that are geared towards planetary science. Rather this be because of the launch frequencies or the costs, the access of small and micro satellites to orbit has been limited. With today's technology it is not possible to escape this circle. However the emergence of cost effective and high performance propulsion systems such as advanced hybrid rockets can decrease launch costs by almost an order or magnitude. This paper briefly introduces the timeline and research challenges that were overcome during the development of advanced hybrid LOX/paraffin based rockets. Experimental studies demonstrated effectiveness of these advanced hybrid rockets which incorporate fast burning parafin based fuels, advanced yet simple internal balistic design and carbon composite winding/fuel casting technology that enables the rocket motor to be built from inside out. A feasibility scenario is studied using these rocket motors as building blocks for a modular launch vehicle capable of delivering micro satellites into low earth orbit. In addition, the building block rocket motor can be used further solar system missions providing the ability to do standalone small and micro satellite missions to planets within the solar system. This enabling technology therefore offers a viable alternative in order to escape the viscous that has plagued the space launch industry and that has limited the small and micro satellite delivery for planetary science.

  9. Broadening the Lens of System-Based Practice: From Micro to Macro and Basic to Complex in Residency Training.

    Science.gov (United States)

    Weinberg, Michael; Arbuckle, Melissa R; Ranz, Jules M

    2017-05-16

    This paper aimed to develop a model for understanding the various dimensions of system-based practice (SBP) and determine the extent to which psychiatry residents perform behaviors along these dimensions. Sixty-one supervisors from seven psychiatry programs rated resident performance of SBP behaviors using a 60-item instrument. Multi-dimensional scaling and cluster analysis were conducted to determine how the instrument items related to one another and the larger concept of SBP. Average supervisor ratings between clusters were compared to determine resident performance along the identified SBP dimensions. The data supports a model of SBP defined along two dimensions: (1) from micro (patient) to macro (population-based) interventions and (2) from low to high system complexity. Residents were more likely to perform behaviors at the patient level compared to those at the population-based level. Training in SBP remains predominately focused on the doctor-patient level and not the greater system of health-care delivery.

  10. Synthesis and characterization of hybrid micro/nano-structured NiTi surfaces by a combination of etching and anodizing.

    Science.gov (United States)

    Huan, Z; Fratila-Apachitei, L E; Apachitei, I; Duszczyk, J

    2014-02-07

    The purpose of this study was to generate hybrid micro/nano-structures on biomedical nickel-titanium alloy (NiTi). To achieve this, NiTi surfaces were firstly electrochemically etched and then anodized in fluoride-containing electrolyte. With the etching process, the NiTi surface was micro-roughened through the formation of micropits uniformly distributed over the entire surface. Following the subsequent anodizing process, self-organized nanotube structures enriched in TiO2 could be superimposed on the etched surface under specific conditions. Furthermore, the anodizing treatment significantly reduced water contact angles and increased the surface free energy compared to the surfaces prior to anodizing. The results of this study show for the first time that it is possible to create hybrid micro/nano-structures on biomedical NiTi alloys by combining electrochemical etching and anodizing under controlled conditions. These novel structures are expected to significantly enhance the surface biofunctionality of the material when compared to conventional implant devices with either micro- or nano-structured surfaces.

  11. Synthesis and characterization of hybrid micro/nano-structured NiTi surfaces by a combination of etching and anodizing

    Science.gov (United States)

    Huan, Z.; Fratila-Apachitei, L. E.; Apachitei, I.; Duszczyk, J.

    2014-02-01

    The purpose of this study was to generate hybrid micro/nano-structures on biomedical nickel-titanium alloy (NiTi). To achieve this, NiTi surfaces were firstly electrochemically etched and then anodized in fluoride-containing electrolyte. With the etching process, the NiTi surface was micro-roughened through the formation of micropits uniformly distributed over the entire surface. Following the subsequent anodizing process, self-organized nanotube structures enriched in TiO2 could be superimposed on the etched surface under specific conditions. Furthermore, the anodizing treatment significantly reduced water contact angles and increased the surface free energy compared to the surfaces prior to anodizing. The results of this study show for the first time that it is possible to create hybrid micro/nano-structures on biomedical NiTi alloys by combining electrochemical etching and anodizing under controlled conditions. These novel structures are expected to significantly enhance the surface biofunctionality of the material when compared to conventional implant devices with either micro- or nano-structured surfaces.

  12. Use of Methanation for Optimization of a Hybrid Plant Combining Two-Stage Biomass Gasification, SOFCs and a Micro Gas Turbine

    DEFF Research Database (Denmark)

    Bang-Møller, Christian; Rokni, Masoud; Elmegaard, Brian

    2011-01-01

    A hybrid plant producing combined heat and power (CHP) from biomass by use of the two-stage gasification concept, solid oxide fuel cells (SOFCs) and a micro gas turbine (MGT) was considered for optimization. The hybrid plant is a sustainable and efficient alternative to conventional decentralized...

  13. TiO2 micro-nano-hybrid surface to alleviate biological aging of UV-photofunctionalized titanium

    Directory of Open Access Journals (Sweden)

    Iwasa F

    2011-06-01

    Full Text Available Fuminori Iwasa1, Naoki Tsukimura1, Yoshihiko Sugita1, Rajita Kodali Kanuru1, Katsutoshi Kubo1, Hafiz Hasnain1, Wael Att1,2, Takahiro Ogawa11Laboratory of Bone and Implant Sciences (LBIS, The Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, CA, USA; 2Department of Prosthodontics, Dental School, Albert-Ludwigs University, Freiburg, GermanyAbstract: Bioactivity and osteoconductivity of titanium degrade over time after surface processing. This time-dependent degradation is substantial and defined as the biological aging of titanium. UV treatment has shown to reactivate the aged surfaces, a process known as photofunctionalization. This study determined whether there is a difference in the behavior of biological aging for titanium with micro-nano-hybrid topography and titanium with microtopography alone, following functionalization. Titanium disks were acid etched to create micropits on the surface. Micro-nano-hybrid surfaces were created by depositioning 300-nm diameter TiO2 nodules onto the micropits using a previously established self-assembly protocol. These disks were stored for 8 weeks in the dark to allow sufficient aging, then treated with UV light for 48 hours. Rat bone marrow–derived osteoblasts were cultured on fresh disks (immediately after UV treatment, 3-day-old disks (disks stored for 3 days after UV treatment, and 7-day-old disks. The rates of cell attachment, spread, proliferation, and levels of alkaline phosphatase activity, and calcium deposition were reduced by 30%–50% on micropit surfaces, depending on the age of the titanium. In contrast, 7-day-old hybrid surfaces maintained equivalent levels of bioactivity compared with the fresh surfaces. Both micropit and micro-nano-hybrid surfaces were superhydrophilic immediately after UV treatment. However, after 7 days, the micro-nano-hybrid surfaces became hydrorepellent

  14. Enzyme-free and isothermal detection of microRNA based on click-chemical ligation-assisted hybridization coupled with hybridization chain reaction signal amplification.

    Science.gov (United States)

    Oishi, Motoi

    2015-05-01

    An enzyme-free and isothermal microRNA (miRNA) detection method has been developed based on click-chemical ligation-assisted hybridization coupled with hybridization chain reaction (HCR) on magnetic beads (MBs). The click-chemical ligation between an azide-modified probe DNA and a dibenzocyclooctyne-modified probe DNA occurred through the hybridization of target miRNA (miR-141). HCR on MBs was performed by the addition of DNA hairpin monomers (H1 and H2). After magnetic separation and denaturation/rehybridization of HCR products ([H1/H2] n ), the resulting HCR products were analyzed by the fluorescence emitted from an intercalative dye, allowing amplification of the fluorescent signal. The proposed assay had a limit of detection of 0.55 fmol, which was 230-fold more sensitive than that of the HCR on the MBs coupled with a conventional sandwich hybridization assay (without click-chemical ligation) (limit of detection 127 fmol). Additionally, the proposed assay could discriminate between miR-141 and other miR-200 family members. In contrast to quantitative reverse transcription polymerase chain reaction techniques using enzymes and thermal cycling, this is an enzyme-free assay that can be conducted under isothermal conditions and can specifically detect miR-141 in fetal bovine serum.

  15. Effect of acidic solutions on the surface degradation of a micro-hybrid composite resin.

    Science.gov (United States)

    Münchow, Eliseu A; Ferreira, Ana Cláudia A; Machado, Raissa M M; Ramos, Tatiana S; Rodrigues-Junior, Sinval A; Zanchi, Cesar H

    2014-01-01

    Composite resins may undergo wear by the action of chemical substances (e.g., saliva, alcohol, bacterial acids) of the oral environment, which may affect the material's structure and surface properties. This study evaluated the effect of acidic substances on the surface properties of a micro-hybrid composite resin (Filtek Z-250). Eighty specimens were prepared, and baseline hardness and surface roughness (KMN0 and Ra0, respectively) were measured. The specimens were subjected to sorption (SO) and solubility (SL) tests according to ISO 4049:2009, but using different storage solutions: deionized water; 75/25 vol% ethanol/water solution; lactic acid; propionic acid; and acetic acid. The acids were used in two concentrations: PA and 0.02 N. pH was measured for all solutions and final hardness (KMN1) and surface roughness (Ra1) were measured. Data were analyzed with paired t-tests and one-way ANOVA and Tukey's test (a=5%). All solutions decreased hardness and increased the Ra values, except for the specimens stored in water and 0.02 N lactic acid, which maintained the hardness. All solutions produced similar SO and SL phenomena, except for the 0.02 N lactic acid, which caused lower solubility than the other solutions. Ethanol showed the highest pH (6.6) and the 0.02 N lactic acid the lowest one (2.5). The solutions affected negatively the surface properties of the composite resin; in addition, an acidic pH did not seem to be a significant factor that intensifies the surface degradation phenomena.

  16. Development and Testing of a Green-Propellant Micro-Hybrid Thruster with Electrostatic Ignition

    Science.gov (United States)

    Whitmore, Stephen A.; Judson, Michael D.

    2012-01-01

    , requiring an energy input of 14,850 Joules for catalytic dissociation. The hydrocarbon-seeded micro-hybrid was also adapted as a non-pyrotechnic ignitor for a 900 N (200-lbf) thrust hybrid motor. The motor was successfully ignited 4 consecutive times with no hardware swaps or propellant additions. The amount of ABS seed material that can be fit into the injector cap is the only limit to the number of available repeat firings. This series of tests marks the first time a hybrid motor was ever ignited by other than a solid-propellant pyrotechnic charge or bi-propellant flame ignitor. Nitrous oxide hybrid motors are typically difficult to ignite and usually require multiple solid-propellant charges to initiate combustion, so this nonpyrotechnic ignition is a significant accomplishment. The controlled hydrocarbon-seeding approach is fundamentally different from all other green propellant solutions offered by the aerospace industry. Although the proposed system is more correctly a hybrid technology; the system retains all the simple features of a monopropellant design. To date no optimization study has been performed to identify the best grain geometry for electrostatic ignition. Fortunately, because the grain segments are fabricated using rapid-prototyping technology, changing the grain geometry is as simple as modifying the 3-D printer CAD-file. Vacuum Isp exceeding 270 seconds has been demonstrated (Ref v), a value significantly higher than those offered by competing green monopropellant options. The propellants of choice, N2O/GOX and ABS are 100% non-toxic, non-explosive, and environmentally benign. Because the inert oxidizer and fuel components are mixed only within the combustion chamber, the system retains the inherent safety of a hybrid rocket and can be piggy-backed as a secondary payload with no overall mission risk increase to the primary payload, an excellent characteristic for secondary launch systems.

  17. Efficient Time-Step Coupling For Hybrid Continuum/Molecular Modelling of Unsteady Micro-Scale Gas Flows

    Science.gov (United States)

    Lockerby, Duncan A.; Duque-Daza, Carlos A.; Borg, Matthew K.; Reese, Jason M.

    2012-05-01

    In this paper we describe a numerical method for the efficient time-accurate coupling of hybrid continuum/molecular micro gas flow solvers. Hybrid approaches are commonly used when non-equilibrium effects in the flow field are spatially localized; in these regions a more accurate, but typically more expensive, solution procedure is adopted. Although this can greatly increase efficiency in steady flows, in unsteady flows the evolution of the solution as a whole is restricted by the maximum time step allowed by the molecular-based/kinetic model; numerically speaking, this is a stiff problem. In the method presented in this paper we exploit time-scale separation, when it exists, to partially decouple the temporal evolution of the two parts of the hybrid model. This affords major computational savings. The method is a modified/extended version of the seamless heterogeneous multiscale method (SHMM). Our approach allows multiple micro steps (molecular steps) before coupling with the macro (continuum) solver: we call this a multi-step SHMM. This maintains the main advantages of SHMM (computational speed-up and flexible application) while improving on accuracy and greatly reducing the number of continuum computations and instances of coupling required. The improved accuracy of the multi-step SHMM is demonstrated for two canonical one-dimensional transient flows (oscillatory Poiseuille and oscillatory Couette flow) and for rarefied-gas oscillatory Poiseuille flow.

  18. Research on Hybrid Isolation System for Micro-Nano-Fabrication Platform

    Directory of Open Access Journals (Sweden)

    Jie Fu

    2014-06-01

    Full Text Available In order to obtain better vibration suppression effect, this paper designs a semiactive/fully active hybrid isolator by using magnetorheological elastomer (MRE and piezoelectric material. Combined with multimode control scheme, full frequency vibration suppression is achieved. Firstly, series type structure is determined for the hybrid isolator, and the structure of hybrid isolator is designed. Next, the dynamic model of hybrid isolator is derived, the dynamic characteristics measurement for MRE isolator and piezoelectric stack actuator (PSA is established, and parameters such as voltage-displacement coefficient, stiffness and damping constant are identified from the experimental results, respectively. Meanwhile, the switch frequency is determined by experimental results of PSA and MRE isolator. Lastly, influence of the stiffness of MRE, control voltage of PSA, and intermediate mass on hybrid isolator system is analyzed by simulations, and the results show that the hybrid isolator proposed is effective.

  19. Nerve guidance conduit with a hybrid structure of a PLGA microfibrous bundle wrapped in a micro/nanostructured membrane

    Science.gov (United States)

    Peng, Shih-Wen; Li, Ching-Wen; Chiu, Ing-Ming; Wang, Gou-Jen

    2017-01-01

    Nerve repair in tissue engineering involves the precise construction of a scaffold to guide nerve cell regeneration in the desired direction. However, improvements are needed to facilitate the cell migration/growth rate of nerves in the center of a nerve conduit. In this paper, we propose a nerve guidance conduit with a hybrid structure comprising a microfibrous poly(lactic-co-glycolic acid) (PLGA) bundle wrapped in a micro/nanostructured PLGA membrane. We applied sequential fabrication processes, including photolithography, nano-electroforming, and polydimethylsiloxane casting to manufacture master molds for the repeated production of the PLGA subelements. After demolding it from the master molds, we rolled the microfibrous membrane into a bundle and then wrapped it in the micro/nanostructured membrane to form a nerve-guiding conduit. We used KT98/F1B-GFP cells to estimate the migration rate and guidance ability of the fabricated nerve conduit and found that both elements increased the migration rate 1.6-fold compared with a flat PLGA membrane. We also found that 90% of the cells in the hybrid nano/microstructured membrane grew in the direction of the designed patterns. After 3 days of culturing, the interior of the nerve conduit was filled with cells, and the microfiber bundle was also surrounded by cells. Our conduit cell culture results also demonstrate that the proposed micro/nanohybrid and microfibrous structures can retain their shapes. The proposed hybrid-structured conduit demonstrates a high capability for guiding nerve cells and promoting cell migration, and, as such, is feasible for use in clinical applications. PMID:28138239

  20. A constrained particle dynamics for continuum-particle hybrid method in micro-and nano-fluidics

    Institute of Scientific and Technical Information of China (English)

    Jia Cui; GuoWei He; Dewei Qi

    2006-01-01

    A hybrid method of continuum and particle dynamics is developed for micro- and nano-fluidics,where fluids are described by a molecular dynamics (MD) in one domain and by the Navier-Stokes (NS) equations in another domain.In order to ensure the continuity of momentum flux,the continuum and molecular dynamics in the overlap domain are coupled through a constrained particle dynamics.The constrained particle dynamics is constructed with a virtual damping force and a virtual added mass force.The sudden-start Couette flows with either non-Slip or slip boundary condition are used to test the hybrid method.It is shown that the results obtained are quantitatively in agreement with the analytical solutions under the non-slip boundary conditions and the full MD simulations under the slip boundary conditions.

  1. Design, testing, and performance of a hybrid micro vehicle---The Hopping Rotochute

    Science.gov (United States)

    Beyer, Eric W.

    The Hopping Rotochute is a new hybrid micro vehicle that has been developed to robustly explore environments with rough terrain while minimizing energy consumption over long periods of time. The device consists of a small coaxial rotor system housed inside a lightweight cage. The vehicle traverses an area by intermittently powering a small electric motor which drives the rotor system, allowing the vehicle to hop over obstacles of various shapes and sizes. A movable internal mass controls the direction of travel while the egg-like exterior shape and low mass center allows the vehicle to passively reorient itself to an upright attitude when in contact with the ground. This dissertation presents the design, fabrication, and testing of a radio-controlled Hopping Rotochute prototype as well as an analytical study of the flight performance of the device. The conceptual design iterations are first outlined which were driven by the mission and system requirements assigned to the vehicle. The aerodynamic, mechanical, and electrical design of a prototype is then described, based on the final conceptual design, with particular emphasis on the fundamental trades that must be negotiated for this type of hopping vehicle. The fabrication and testing of this prototype is detailed as well as experimental results obtained from a motion capture system. Basic flight performance of the prototype are reported which demonstrates that the Hopping Rotochute satisfies all appointed system requirements. A dynamic model of the Hopping Rotochute is also developed in this thesis and employed to predict the flight performance of the vehicle. The dynamic model includes aerodynamic loads from the body and rotor system as well as a soft contact model to estimate the forces and moments during ground contact. The experimental methods used to estimate the dynamic model parameters are described while comparisons between measured and simulated motion are presented. Good correlation between these motions

  2. Hybrid Solid Oxide Fuel Cell and Thermoelectric Generator for Maximum Power Output in Micro-CHP Systems

    DEFF Research Database (Denmark)

    Rosendahl, Lasse; Mortensen, Paw Vestergård; Enkeshafi, Ali A.

    2011-01-01

    and market segments which are not yet quantified. This paper quantifies a micro-CHP system based on a solid oxide fuel cell (SOFC) and a high-performance TE generator. Based on a 3 kW fuel input, the hybrid SOFC implementation boosts electrical output from 945 W to 1085 W, with 1794 W available for heating......One of the most obvious early market applications for thermoelectric generators (TEG) is decentralized micro combined heat and power (CHP) installations of 0.5 kWe to 5 kWe based on fuel cell technology. Through the use of TEG technology for waste heat recovery it is possible to increase...... the electricity production in micro-CHP systems by more than 15%, corresponding to system electrical efficiency increases of some 4 to 5 percentage points. This will make fuel cell-based micro-CHP systems very competitive and profitable and will also open opportunities in a number of other potential business...

  3. Hybrid Solid Oxide Fuel Cell and Thermoelectric Generator for Maximum Power Output in Micro-CHP Systems

    Science.gov (United States)

    Rosendahl, L. A.; Mortensen, Paw V.; Enkeshafi, Ali A.

    2011-05-01

    One of the most obvious early market applications for thermoelectric generators (TEG) is decentralized micro combined heat and power (CHP) installations of 0.5 kWe to 5 kWe based on fuel cell technology. Through the use of TEG technology for waste heat recovery it is possible to increase the electricity production in micro-CHP systems by more than 15%, corresponding to system electrical efficiency increases of some 4 to 5 percentage points. This will make fuel cell-based micro-CHP systems very competitive and profitable and will also open opportunities in a number of other potential business and market segments which are not yet quantified. This paper quantifies a micro-CHP system based on a solid oxide fuel cell (SOFC) and a high-performance TE generator. Based on a 3 kW fuel input, the hybrid SOFC implementation boosts electrical output from 945 W to 1085 W, with 1794 W available for heating purposes.

  4. The influence of hierarchical hybrid micro/nano-textured titanium surface with titania nanotubes on osteoblast functions.

    Science.gov (United States)

    Zhao, Lingzhou; Mei, Shenglin; Chu, Paul K; Zhang, Yumei; Wu, Zhifen

    2010-07-01

    Hierarchical hybrid micro/nano-textured titanium surface topographies with titania nanotubes were produced by simple acid etching followed by anodization to mimic the hierarchical structure of bone tissues. Primary rat osteoblasts were used to evaluate the bioactivity. The microtopography formed by acid etching of titanium induced inconsistent osteoblast functions with initial cell adhesion and osteogenesis-related gene expression being dramatically enhanced while other cell behaviors such as proliferation, intracellular total protein synthesis and alkaline phosphatase activity, collagen secretion, and extracellular matrix mineralization being depressed. In comparison, addition of nanotubes to the microtopography led to enhancement of multiple osteoblast functions. Nearly all the cell functions investigated in this study were retained or promoted. Compared to a microtopography, the enhancement of multiple cell functions observed from the hierarchical micro/nano-textured surfaces is expected to lead to faster bone maturation around the titanium implants without compromising the bone mass. In addition, the hierarchical micro/nano-textured surfaces still retain the mechanical interlocking ability of the microtopography thereby boding well for osseointegration. Our study reveals a synergistic role played by the micro and nanotopographies in osteoblast functions and provides insight to the design of better biomedical implant surfaces.

  5. Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation

    Science.gov (United States)

    Fuse, Shinichiro; Mifune, Yuto; Nakamura, Hiroyuki; Tanaka, Hiroshi

    2016-11-01

    Feglymycin is a naturally occurring, anti-HIV and antimicrobial 13-mer peptide that includes highly racemizable 3,5-dihydroxyphenylglycines (Dpgs). Here we describe the total synthesis of feglymycin based on a linear/convergent hybrid approach. Our originally developed micro-flow amide bond formation enabled highly racemizable peptide chain elongation based on a linear approach that was previously considered impossible. Our developed approach will enable the practical preparation of biologically active oligopeptides that contain highly racemizable amino acids, which are attractive drug candidates.

  6. T-joints of Ti alloys with hybrid laser-MIG welding: macro-graphic and micro-hardness analyses

    Science.gov (United States)

    Spina, R.; Sorgente, D.; Palumbo, G.; Scintilla, L. D.; Brandizzi, M.; Satriano, A. A.; Tricarico, L.

    2012-03-01

    Titanium alloys are characterized by high mechanical properties and elevated corrosion resistance. The combination of laser welding with MIG/GMAW has proven to improve beneficial effects of both processes (keyhole, gap-bridging ability) while limiting their drawbacks (high thermal gradient, low mechanical resistance) In this paper, the hybrid Laser-GMAW welding of Ti-6Al-4V 3-mm thick sheets is investigated using a specific designed trailing shield. The joint geometry was the double fillet welded T-joint. Bead morphologies, microstructures and mechanical properties (micro-hardness) of welds were evaluated and compared to those achieved for the base metals.

  7. A Sensitive Alternative for MicroRNA In Situ Hybridizations Using Probes of 2'-O-Methyl RNA + LNA

    DEFF Research Database (Denmark)

    Søe, Martin Jensen; Møller, Trine; Dufva, Martin;

    2011-01-01

    The use of short, high-affinity probes consisting of a combination of DNA and locked nucleic acid (LNA) has enabled the specific detection of microRNAs (miRNAs) by in situ hybridization (ISH). However, detection of low–copy number miRNAs is still not always possible. Here the authors show...... that probes consisting of 2'-O-methyl RNAs (2OMe) and LNA at every third base (2:1 ratio), under optimized hybridization conditions, excluding yeast RNA from the hybridization buffer, can provide superior performance in detection of miRNA targets in terms of sensitivity and signal-to-noise ratio compared...... to DNA + LNA probes. Furthermore, they show that hybridizations can be performed in buffers of 4M urea instead of 50% formamide, thereby yielding an equally specific but nontoxic assay. The use of 2OMe + LNA–based probes and the optimized ISH assay enable simple and fast detection of low–copy number mi...

  8. 青年人眼晶状体的显微研究及其临床意义%Study on micro-anatomy of the lens of the normal adult cadaver eyes

    Institute of Scientific and Technical Information of China (English)

    梁皓; 谭少健; 黄明汉; 区显宁

    2001-01-01

    目的 通过对正常成人尸眼晶状体的显微解剖研究,推动白内障摘出及人工晶状体(IOL)植入术的改进。方法 测量53人共102只成年尸眼(年龄19~41a)的晶状体直径(LD)及无韧带区直径(ZFZ)等有关正常值。结果 正常成年人LD平均为9.61mm,ZFZ为7.73mm,ZFZ与LD呈直线正相关关系;晶状体核直径(ND)平均为7.68mm,核厚度(NT)为2.9mm,同一人的LD、ND、NT呈直线正相关关系;晶状体囊袋直径(CBD)平均为10.15mm,与LD比较有显著差异。结论 成年人白内障摘出术中连续环形撕前囊应在5~6mm之间。%Objective To study the micro-anatomy of the lens of the normaladult cadaver eyes in order to complement the lens micro-anatomical theory and improve the cataract extraction and the intraocular lens (IOL) implantation.Methods The mean values of the lens diameter (LD) and the zonular-free zone diameter (ZFZ) in 102 eyes of 53 cadavers were measured. Results The mean LD and ZFZ were 9.61mm,7.73mm respectively. The larger the LD,the larger the ZFZ. The diameter of the lens nucleus (ND) was 7.68mm, the lens nucleus thickness (NT) was 2.9mm. There is a linear positive correlation between the right eye and the left eye of a man. The mean capsular bag diameter (CBD) was 10.15mm,larger than LD.Conclusion It is recommended that the capsular opening diameter be from 5 to 6mm in adult cataract extraction.

  9. Hybrid nanostructured thin-films by PLD for enhanced field emission performance for radiation micro-nano dosimetry applications

    Energy Technology Data Exchange (ETDEWEB)

    Manikandan, E., E-mail: maniphysics@gmail.com [UNESCO-UNISA AFNET in Nanosciences/Nanotechnology, College of Graduate Studies, University of South Africa, Muckleneuk Ridge, PO Box 392, Pretoria (South Africa); Nanosciences African Network (NANOAFNET), Materials Research Department, iThemba LABS–National Research Foundation (NRF), 1 Old Faure Road, Somerset West, PO Box 722, Western Cape (South Africa); Materials Science Group (MSG), Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam 603102 (India); Corrosion Science and Technology Group, Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam 603102 (India); Sree Balaji Medical College & Hospital (SBMCH), Bharath University, Chrompet, Chennai 600044 (India); Kennedy, J. [UNESCO-UNISA AFNET in Nanosciences/Nanotechnology, College of Graduate Studies, University of South Africa, Muckleneuk Ridge, PO Box 392, Pretoria (South Africa); Nanosciences African Network (NANOAFNET), Materials Research Department, iThemba LABS–National Research Foundation (NRF), 1 Old Faure Road, Somerset West, PO Box 722, Western Cape (South Africa); The MacDiarmid Institute for Advanced Materials and Nanotechnology (New Zealand); Kavitha, G. [UNESCO-UNISA AFNET in Nanosciences/Nanotechnology, College of Graduate Studies, University of South Africa, Muckleneuk Ridge, PO Box 392, Pretoria (South Africa); Nanosciences African Network (NANOAFNET), Materials Research Department, iThemba LABS–National Research Foundation (NRF), 1 Old Faure Road, Somerset West, PO Box 722, Western Cape (South Africa); PG& Research Dept of Physics, AM Jain College Affiliated to University of Madras, Chennai 600114 (India); and others

    2015-10-25

    We report the observation of hybrid nanostructured thin-films such as diamond-like carbon (DLC) signature on the ZnO epitaxial thin-films grown onto the device silicon/quartz substrate by reactive pulsed laser deposition (r-PLD) under the argon–oxygen (Ar|O{sub 2}) ambient at 573 K. Undoped and Carbon (C) doped epitaxial ZnO thin-film layer formation is revealed by the accelerator based ion-beam analysis (IBA) technique of resonant Rutherford backscattering spectrometry (RRBS), glancing-incidence X-ray diffraction (GIXRD) pattern, micro-Raman spectroscopy (μ-RS) and field-emission (F-E) studies. The RRBS and GIXRD results show the deposition of epitaxial thin-films containing C into ZnO. The μ-RS technique is a standard nondestructive tool (NDT) for the characterization of crystalline, nano-crystalline, and amorphous carbons (a-C). As grown ZnO and C-doped ZnO thin-films μ-RS result reveal the doping effect of C-impurities that appear in the form of DLC evident from Raman peaks at 1357 and 1575 cm{sup −1} along with a wurtzite structure peak at 438 cm{sup −1} with E{sub 2}(h) phonon of ZnO. The electron transport F-E result shows the hybrid thin-films has high conductivity than the un-doped film. Fabricated hybrid nanostructured thin-films materials could be very useful for the emerging applications of micro-nano dosimetry. - Highlights: • Observation of hybrid nanostructured diamond-like carbon (DLC) on ZnO epitaxial thin-films at 573 K. • Carbon doped epitaxial ZnO thin-film layer formation is revealed by RRBS, Micro-Raman. • Field-emission (F-E) study. • DLC formation evident from Raman peaks at 1357 and 1575 cm{sup −1} along with a wurtzite structure peak of ZnO. • The electron transport F-E result shows the hybrid thin-film has high conductivity than the undoped thin-film.

  10. Hybrid tooling technologies and standardization for the manufacturing of inserts for micro injection molding

    DEFF Research Database (Denmark)

    Tosello, Guido; Fillon, Bertrand; Azcarate, Sabino

    2007-01-01

    . A metrological approach was applied to standardize the employed tooling processes (micro milling, µEDM, laser micromachining, electrochemical µ-milling). The micro tools were then tested with different polymers (PP, PP + nano fillers, PC, COC). The paper provides a comparison of these technologies concerning...

  11. Hybrid tooling technologies and standardization for the manufacturing of inserts for micro injection molding

    DEFF Research Database (Denmark)

    Tosello, Guido; Fillon, Bertrand; Azcarate, Sabino;

    2007-01-01

    . A metrological approach was applied to standardize the employed tooling processes (micro milling, µEDM, laser micromachining, electrochemical µ-milling). The micro tools were then tested with different polymers (PP, PP + nano fillers, PC, COC). The paper provides a comparison of these technologies concerning...

  12. DNA-DNA hybridization determined in micro-wells using covalent attachment of DNA

    DEFF Research Database (Denmark)

    Christensen, H.; Angen, Øystein; Mutters, R.;

    2000-01-01

    by covalent attachment to NucleoLink. Hybridization was performed with 500 ng DNA, 5% (w/w) of which was labelled with photo-activatable biotin (competitive hybridization) for 2.5 h at 65 degrees C in 2 x SSC followed by stringent washing with 2 x SSC at the same temperature. The criteria for acceptance...

  13. Hybrid micro/nano-structure formation by angular laser texturing of Si surface for surface enhanced Raman scattering.

    Science.gov (United States)

    Xu, Kaichen; Zhang, Chentao; Zhou, Rui; Ji, Rong; Hong, Minghui

    2016-05-16

    Surface enhanced Raman spectroscopy (SERS) has drawn much research interest in the past decades as an efficient technique to detect low-concentration molecules. Among many technologies, which can be used to fabricate SERS substrates, laser ablation is a simple and high-speed method to produce large-area SERS substrates. This work investigates the angular texturing effect by dynamic laser ablation and its influence on SERS signals. By tuning the angle between the Si surface and laser irradiation, the distributions and sizes of laser induced hybrid micro/nano-structures are studied. By decorating with a silver film, plenty of hot spots can be created among these structures for SERS. It is found that when the incident laser angle is 15° at the laser fluence of 16.0 J/cm2, the SERS performance is well optimized. This work realizes antisymmetric distribution of nanoparticles deposited on Si surface, which provides a flexible tuning of the hybrid micro/nano-structures' fabrication with high controllability for practical applications.

  14. Nerve guidance conduit with a hybrid structure of a PLGA microfibrous bundle wrapped in a micro/nanostructured membrane

    Directory of Open Access Journals (Sweden)

    Peng SW

    2017-01-01

    Full Text Available Shih-Wen Peng,1 Ching-Wen Li,2 Ing-Ming Chiu,3,4 Gou-Jen Wang1–3 1Graduate Institute of Biomedical Engineering, 2Department of Mechanical Engineering, 3PhD Program in Tissue Engineering and Regenerative Medicine, National Chung-Hsing University, Taichung, 4Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan Abstract: Nerve repair in tissue engineering involves the precise construction of a scaffold to guide nerve cell regeneration in the desired direction. However, improvements are needed to facilitate the cell migration/growth rate of nerves in the center of a nerve conduit. In this paper, we propose a nerve guidance conduit with a hybrid structure comprising a microfibrous poly(lactic-co-glycolic acid (PLGA bundle wrapped in a micro/nanostructured PLGA membrane. We applied sequential fabrication processes, including photolithography, nano-electroforming, and polydimethylsiloxane casting to manufacture master molds for the repeated production of the PLGA subelements. After demolding it from the master molds, we rolled the microfibrous membrane into a bundle and then wrapped it in the micro/nanostructured membrane to form a nerve-guiding conduit. We used KT98/F1B-GFP cells to estimate the migration rate and guidance ability of the fabricated nerve conduit and found that both elements increased the migration rate 1.6-fold compared with a flat PLGA membrane. We also found that 90% of the cells in the hybrid nano/microstructured membrane grew in the direction of the designed patterns. After 3 days of culturing, the interior of the nerve conduit was filled with cells, and the microfiber bundle was also surrounded by cells. Our conduit cell culture results also demonstrate that the proposed micro/nanohybrid and microfibrous structures can retain their shapes. The proposed hybrid-structured conduit demonstrates a high capability for guiding nerve cells and promoting cell migration, and, as such, is

  15. Multi-scale and angular analysis of ray-optical light trapping schemes in thin-film solar cells: micro lens array, V-shaped configuration, and double parabolic trapper.

    Science.gov (United States)

    Cho, Changsoon; Lee, Jung-Yong

    2013-03-11

    An efficient light trapping scheme is a key to enhancing the power conversion efficiency (PCE) of thin-film photovoltaic (PV) cells by compensating for the insufficient light absorption. To handle optical components from nano-scale to micro-scale seamlessly, a multi-scale optical simulation is carefully designed in this study and is used to qualitatively analyze the light trapping performances of a micro lens array (MLA), a V-shaped configuration, and the newly proposed scheme, which is termed a double parabolic trapper (DPT) according to both daily and annual movement of the sun. DPT has the potential to enhance the PCE significantly, from 5.9% to 8.9%, for PCDTBT:PC(70)BM-based polymer solar cells by perfectly trapping the incident light between two parabolic PV cells.

  16. In situ micro-focused X-ray beam characterization with a lensless camera using a hybrid pixel detector

    Energy Technology Data Exchange (ETDEWEB)

    Kachatkou, Anton, E-mail: anton.kachatkou@manchester.ac.uk [The University of Manchester, Sackville Street Building, Manchester M13 9PL (United Kingdom); Marchal, Julien [Diamond Light Source Ltd, Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom); Silfhout, Roelof van, E-mail: anton.kachatkou@manchester.ac.uk [The University of Manchester, Sackville Street Building, Manchester M13 9PL (United Kingdom)

    2014-02-04

    Position and size measurements of a micro-focused X-ray beam, using an X-ray beam imaging device based on a lensless camera that collects radiation scattered from a thin foil placed in the path of the beam at an oblique angle, are reported. Results of studies on micro-focused X-ray beam diagnostics using an X-ray beam imaging (XBI) instrument based on the idea of recording radiation scattered from a thin foil of a low-Z material with a lensless camera are reported. The XBI instrument captures magnified images of the scattering region within the foil as illuminated by the incident beam. These images contain information about beam size, beam position and beam intensity that is extracted during dedicated signal processing steps. In this work the use of the device with beams for which the beam size is significantly smaller than that of a single detector pixel is explored. The performance of the XBI device equipped with a state-of-the-art hybrid pixel X-ray imaging sensor is analysed. Compared with traditional methods such as slit edge or wire scanners, the XBI micro-focused beam characterization is significantly faster and does not interfere with on-going experiments. The challenges associated with measuring micrometre-sized beams are described and ways of optimizing the resolution of beam position and size measurements of the XBI instrument are discussed.

  17. Evaluation of Eleven Macro and Micro Elements Present in Various Hybrids of Millet (Pennisetum glaucum, or P. Americanum

    Directory of Open Access Journals (Sweden)

    Ghulam Qadir Shar

    2012-06-01

    Full Text Available Maize and Millet Research Institute (MMRI situated in Yousuf wala, District Sahiwal, Punjab, Pakistan was selected to grow nine different hybrids/cultivars of millet for study to comprehend the variable concentration of macro, micro and trace and toxic elements in their grains. Wet digestion method was used for the preparation of samples and flame atomic absorption spectrophotometer for analysis of eleven major and minor elements. High values of macro-elements i.e. sodium and potassium was found in ICMP-451 and magnesium in ICMP-53506. The high value of essential micro-elements i.e.zinc (50mg/kg, manganese (8mg/kg, and copper (8mg/kg was calculated in ICMP-53506, Bullo-94-1, and ICMP-83720 respectively. In case of trace and toxic micro-elements, high concentration of nickel, cobalt, chromium and cadmium was found in O.B.V, Bullo-7704, ICMP-83401, and ICMP-83720 in the edible part of millet plants (grains cultivars respectively.

  18. Power and temperature control of fluctuating biomass gas fueled solid oxide fuel cell and micro gas turbine hybrid system

    Science.gov (United States)

    Kaneko, T.; Brouwer, J.; Samuelsen, G. S.

    This paper addresses how the power and temperature are controlled in a biomass gas fueled solid oxide fuel cell (SOFC) and micro gas turbine (MGT) hybrid system. A SOFC and MGT dynamic model are developed and used to simulate the hybrid system performance operating on biomass gas. The transient behavior of both the SOFC and MGT are discussed in detail. An unstable power output is observed when the system is fed biomass gas. This instability is due to the fluctuation of gas composition in the fuel. A specially designed fuel controller succeeded not only in allowing the hybrid system to follow a step change of power demand from 32 to 35 kW, but also stably maintained the system power output at 35 kW. In addition to power control, fuel cell temperature is controlled by introduction and use of a bypass valve around the recuperator. By releasing excess heat to the exhaust, the bypass valve provided the control means to avoid the self-exciting behavior of system temperature and stabilized the temperature of SOFC at 850 °C.

  19. Degree of conversion of micro-hybrid, nano-hybrid and Ormocer composites using LED and QTH light-curing units

    Directory of Open Access Journals (Sweden)

    Seied Mostafa Fatemi

    2012-01-01

    Full Text Available Background and Aims: The aim of this study was to measure the degree of conversion (DC of three types of composite resins (micro-hybrid, nano-hybrid and Ormocer with different light curing units (LED LCU and QTH LCU in two depths.Materials and Methods: Three commercially available dental resin composites were used in this study: (Tetric Ceram, Ivoclar Vivadent, Liechtenstein-A2 shade, (Tetric Evoceram, Ivoclar Vivadent, Liechtenstein-A2 shade, (Ceram X, Dentsply, Germany-M2 shade. Specimens were divided into two groups, 5 specimens were photo-activated by QTH unit (Coltolux 75-Colten and the other five specimens were cured by LED (Demi-Kerr. Then each specimen was sectioned at the top surface and at 2-mm depth. The DC was measured by FT-IR(Bruker-tensor 27. The data were analyzed by 3-way ANOVA test.Results: There was significant difference between tested composite resins (P<0.001. The results of top surfaces were significantly different from those observed at 2-mm depth (P<0.001. The type of curing unit affected the polymerization of Ceram X resin composite.Conclusion: This study showed a significant difference in the degree of conversion in different thicknesses within three groups of resin composites.

  20. Hybrid organic-inorganic silica monolith with hydrophobic/strong cation-exchange functional groups as a sorbent for micro-solid phase extraction.

    Science.gov (United States)

    Zheng, Ming-Ming; Ruan, Ge-Deng; Feng, Yu-Qi

    2009-11-06

    A hybrid organic-inorganic silica monolith with hydrophobic and strong cation-exchange functional groups was prepared and used as a sorbent for micro-solid phase extraction (micro-SPE). The hybrid silica monolith functionalized with octyl and thiol groups was conveniently synthesized by hydrolysis and polycondensation of a mixture of tetraethoxysilane (TEOS), n-octyltriethoxysilane (C8-TEOS) and 3-mercaptopropyltrimethoxysilane (MPTMS) via a two-step catalytic sol-gel process. Due to the favorable chemical reactivity of mercapto pendant moieties, the obtained hybrid monolith was oxidized using hydrogen peroxide (30%, w/w) to yield sulfonic acid groups, which provided strong cation-exchange sites. The obtained hybrid monolith was characterized by diffused infrared spectroscopy, elemental analysis, scanning electron microscopy and mercury intrusion porosimetry. The results show that the resulting monolith contains much higher carbon (31.6%) and sulfur (4.8%) contents than traditionally bonded silica materials. The extraction performance of the hybrid monolith was evaluated using sulfonamides as testing analytes by micro-SPE on-line coupled to HPLC. The results show that the hybrid monolith with hydrophobic and strong cation-exchange functional groups exhibits high extraction efficiency towards the testing analytes. The column-to-column RSD values were 1.3-9.8% for the extraction of SAs investigated. The extraction performance of the hybrid silica monolith remained practically unchanged after treated with acid (pH 1.0) and basic solutions (pH 10.5). Finally, the application of the hybrid monolith was demonstrated by micro-SPE of sulfonamide residues from milk followed by HPLC-UV analysis. The limits of detection (S/N=3) for eight SAs were found to be 1.0-3.0ng/mL in milk. The recoveries of eight SAs spiked in milk sample ranged from 80.2% to 115.6%, with relative standard deviations less than 11.8%.

  1. Observation of the induced pressure in a hybrid micro/nano-channel

    Institute of Scientific and Technical Information of China (English)

    KONG Gao-pan; ZHENG Xu; SILBER-LI Zhan-hua; XU Zheng

    2013-01-01

    This paper studies the flow characteristics in micro/nano-channels subjected to an applied electric field.The nano-channel flow was observed by means of the fluorescence Calcein.A Fluorescence Concentration Gradient Interface (FCGI) was observed across the nano-channel array.The front of the FCGI was shown to have an analogous parabolic shape.The propagation of this interface reflects indirectly the induced pressure at the micro/nano-channel junction,where the enrichment-depletion processes are known to take place.This induced pressure was predicted by numerical simulations,and this paper gives the first experimental evidence.

  2. P.I.X.S.C.A.N.: a micro-CT scanner for small animal based on hybrid pixel detectors; PIXSCAN: micro-tomodensitrometre a pixels hybrides pour le petit animal

    Energy Technology Data Exchange (ETDEWEB)

    Khoury, R

    2008-03-15

    Since more than a dozen years, efforts were led in the field of X-ray tomography for small animals, principally for the improvement of spatial resolution and the diminution of the absorbed dose. The C.P.P.M. developed the micro-CT P.I.X.S.C.A.N. based on the hybrid pixel detector X.P.A.D.2. In this context, my thesis work consists in studying the demonstrator P.I.X.S.C.A.N./X.P.A.D.2 and the contribution of the hybrid pixels in the imaging of small animals. A fast analytical simulation, FastSimu, was developed. An extrapolation of the performance of the demonstrator P.I.X.S.C.A.N, as well as the validation of the results obtained with the measured data, were led by means of the analytical simulator FastSimu. The demonstrator P.I.X.S.C.A.N./X.P.A.D.2 allowed to obtain reconstructed images with a rather good quality for a relatively weak absorbed dose. Its spatial resolution is degraded by the high number of defective pixels of the detector X.P.A.D.2. Beyond this study, a new version of the demonstrator P.I.X.S.C.A.N./X.P.A.D.2 is under construction. This latter, characterized by two and a half times smaller pixels and about no defective pixels will bring a considerable improvement on spatial resolution. (author)

  3. Micro-mechanics of nanostructured carbon/shape memory polymer hybrid thin film

    NARCIS (Netherlands)

    Lei, M.; Xu, B.; Pei, Yutao T.; Lu, H.B.; Fu, Y.Q.

    2016-01-01

    This paper investigates the mechanics of hybrid shape memory polymer polystrene (PS) based nanocomposites with skeletal structures of CNFs/MWCNTs formed inside. Experimental results showed an increase of glass transition temperature (Tg) with CNF/MWCNT concentrations instead of a decrease of Tg in n

  4. Evaluation Of Electrical And Thermal Performance Of A Linear Hybrid CPV-T Micro-Concentrator System

    Science.gov (United States)

    Everett, Vernie; Harvey, Judy; Surve, Sachin; Thomsen, Elizabeth; Walter, Daniel; Vivar, Marta; Blakers, Andrew; Tanner, Andrew; Greaves, Mikal; Le Leivre, Peter

    2011-12-01

    Chromasun Inc. and The Australian National University have developed a low-concentration, linear, hybrid micro-concentrator (MCT) system suitable for urban rooftop installation. The system produces both electrical and thermal power, integrating the functionality of separate flat plate photovoltaic and solar hot water systems. The MCT system utilises industry-standard components, including modified mono-crystalline silicon one-sun solar cells, commonly used in flat panel applications. The MCT manufacturing processes are designed around low-cost methods, and tap directly into existing economies of scale. Initial test results without any system optimisation has demonstrated an electrical output of more than 300 W, and a thermal output of more than 1500 W at 950 W/m2 DNI.

  5. Lens Model

    DEFF Research Database (Denmark)

    Nash, Ulrik William

    2014-01-01

    Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory of probabil......Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory...... of probabilistic functionalism, and concerns the environment and the mind, and adaptation by the latter to the former. This entry is about the lens model, and probabilistic functionalism more broadly. Focus will mostly be on firms and their employees, but, to fully appreciate the scope, we have to keep in mind...

  6. Lens Model

    DEFF Research Database (Denmark)

    Nash, Ulrik William

    2014-01-01

    Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory of probabil......Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory...

  7. Energy Management of a Hybrid AC–DC Micro-Grid Based on a Battery Testing System

    Directory of Open Access Journals (Sweden)

    Bo Long

    2015-02-01

    Full Text Available Energy Recovery Battery Testing Systems (ERBTS plays an important role in battery manufacture. The conventional ERBTS configuration contains a fundamental transformer, and a bidirectional Direct Current (DC–DC and Alternating Current (AC–DC converter. All ERBTS are connected in parallel, thus constituting a special and complicated AC micro-grid system. Aiming at addressing their low energy recovery efficiency, complex grid-connected control algorithm issues for islanded detection, and complicated power circuit topology issues, a hierarchical DC-link voltage hybrid AC–DC micro-grid that contains composite energy storing devices is proposed. Moreover, an energy management optimal scheme for the proposed scheme is put forward. The system configuration of the proposed scheme is described in detail. Compared to the conventional scheme, the proposed scheme has the merits of simplified power circuit topology, no need for phase synchronous control, and much higher energy recovery efficiency and reliability. The validity and effectiveness of the proposed technique is verified through numerous experimental results.

  8. Label-free quantification of microRNAs using ligase-assisted sandwich hybridization on a DNA microarray.

    Directory of Open Access Journals (Sweden)

    Taro Ueno

    Full Text Available MicroRNAs (miRNAs can be used as biomarkers for cancer and other human diseases; therefore, high-throughput and reliable miRNA-quantification methods are required to exploit these markers for diagnostic testing. In this report, we describe the construction of a platform for miRNA-quantification using ligase-assisted sandwich hybridization (LASH without miRNA-labeling. T4 DNA ligase was used to compensate for the low affinity between miRNAs and two short complementary DNA probes, and it improved the hybridization yield ∼50,000 times. The LASH assay enabled synthesized miR-143 to be quantified at concentrations ranging from 30 fM to 30 pM. The LASH assay could also quantify endogenous miR-143 released from cultured cells as well as some miRNAs in total RNAs derived from blood. Furthermore, multi-color detection enabled us to distinguish between the highly homologous miR-141 and miR-200a. This simple label-free quantification technique is an easy-to-use approach that can be applied to disease diagnosis.

  9. Effects of Plant Density on Yield and Canopy Micro Environment in Hybrid Cotton

    Institute of Scientific and Technical Information of China (English)

    YANG Guo-zheng; LUO Xue-jiao; NIE Yi-chun; ZHANG Xian-long

    2014-01-01

    A rational plant population is an important attribute to high yield of cotton, because it can provide a beneifcial micro environment within the canopy for plant growth and development as well as yield formation. A 2-yr ifeld experiment was conducted to determine the optimal plant density based on cotton yield in relation to the canopy micro environment (canopy temperature, relative humidity and light transmittance). Six plant densities (1.2-5.7 plants m-2) were arranged with a completely randomized block design. The highest cotton yield (1 507 kg ha-1) was obtained at 3.0 plants m-2 due to more bolls per unit ground area (79 bolls m-2), while the lowest yield (1 091 kg ha-1) was obtained at 1.2 plants m-2. Under the moderate plant density (3.0 plants m-2), there was a lower mean daily temperature (MDT, 27.1°C) attributing to medium daily minimum temperature (Tmin, 21.9°C) and the lowest daily maximum temperature (Tmax, 35.8°C), a moderate mean canopy light transmittance of 0.51, and lower mean daily relative humidity (MRH) of 79.7%from June to October. The results suggest that 3.0 plants m-2 would be the optimal plant density because it provides a better canopy micro environment.

  10. Thermodynamic Performance Study of Biomass Gasification, Solid Oxide Fuel Cell and Micro Gas Turbine Hybrid Systems

    DEFF Research Database (Denmark)

    Bang-Møller, Christian; Rokni, Masoud

    2010-01-01

    A system level modelling study of three combined heat and power systems based on biomass gasification is presented. Product gas is converted in a micro gas turbine (MGT) in the first system, in a solid oxide fuel cell (SOFC) in the second system and in a combined SOFC–MGT arrangement in the third...... system. An electrochemical model of the SOFC has been developed and calibrated against published data from Topsoe Fuel Cells A/S and the Risø National Laboratory. The modelled gasifier is based on an up scaled version (~500 kW_th) of the demonstrated low tar gasifier, Viking, situated at the Technical...

  11. Hybrid micro-GA based FLCs for TCSC and UPFC in a multi-machine environment

    Energy Technology Data Exchange (ETDEWEB)

    Khan, Laiq [GIK Institute Topi, Swabi (Pakistan); Lo, K.L. [University of Strathclyde, Glasgow (United Kingdom)

    2006-06-15

    In this paper, a systematic fuzzy logic based damping control system design for TCSC and UPFC is proposed to enhance the power system stability spectrum. Firstly, the fuzzy membership functions and control rules are extracted based on the recorded or monitored signals. Then, the novel 'Grand-Parenting' technique is employed to incorporate the non-optimal fuzzy logic controllers in micro-GA ({mu}-GA) to search for optimal fuzzy membership functions and rules simultaneously. Simulation studies have been carried out to show the effectiveness and robustness of the proposed damping control strategy in a multi-machine power system setup. (author)

  12. 应用微柱透镜的自由立体前投影屏幕设计%Autostereoscopic Front Projection System Based on Micro-Lenticular Lens Array

    Institute of Scientific and Technical Information of China (English)

    马建设; 张波常; 苏萍; 程雪岷

    2012-01-01

    介绍了应用微柱透镜阵列的自由立体前投影显示的原理.推导出确定自由立体前投影屏幕中微柱透镜参数的公式,详细给出了一种设计方法.根据此方法设计了一块采用微柱透镜阵列的自由立体前投影屏幕,在Lighttools中对采用此屏幕的投影系统进行仿真模拟,仿真结果显示有5个比较明显的视区,视区间隔比较连续.搭建屏幕和投影系统进行实验验证,实验结果与仿真结果一致,串扰度为7.9%,图像重合度为1.008,在观察面处立体效果显著.实验结果验证了应用微柱透镜阵列的自由立体前投影显示的可行性.与背投影的自由立体显示技术相比,自由立体前投影显示具有装调快、占用空间小、投影距离灵活可调的优点,将是未来大屏幕自由立体显示的一个重要发展方向.%The principle of autostereoscopic front projection display based on micro-lenticular lens array is introduced. Formulas to determine the parameters of the micro-lenticular lens are deduced and a method to design the micro-lenticular lens array is proposed. A piece of stereoscopic projection screen is designed based on the method and the whole projection system with the screen is emulated in Lighttools. The simulation result shows that there are five definite viewing zones. The distance of the adjacent viewing zone is very close to each other. The projection system is built up and the observe plane is at the vertical plane with the projectors. The crosstalk is 7. 9% and overlap ratio is 1. 008. The final result is consistent with the simulation result and the autostereoscopic display effect is good. The experimental results show that the autostereoscopic front projection display based on micro-lenticular lens is feasible. Compared to autostereoscopic rear projection, the autostereoscopic front projection display has the advantages of simple implementing, compact structure and adjustable projection distance, therefore it

  13. Micro Analyses AC/DC Hybrid Power Grid Planning and Design%交直流混合微电网的规划设计

    Institute of Scientific and Technical Information of China (English)

    王红阳

    2016-01-01

    由于交直流混合微电网可以减少多重变换器运行所产生的损耗、谐波电流,同时能够提高系统的经济性、可靠性,所以现在已成为当今微电网的主要发展方向。笔者将从电压等级、接地方式、母线结构和网络拓扑等角度,探讨交直流混合微电网的规划设计,以供有意对交直流混合微电网进行深入研究的专家学者参考。%Due to micro AC/DC hybrid power grid can reduce multiple converter loss, harmonic current generated by the operation, at the same time can improve the efficiency of system, the reliability, so now it is the main direction of micro grid today. Grounding method, the author will from voltage grade, bus structure and network topology of micro AC/DC hybrid power grid planning and design were discussed, for the intention to conduct the thorough research to the micro AC/DC hybrid power grid in the experts and scholars to provide the reference.

  14. Study of Micro Grid Hybrid System of Photovoltaic and Diesel Engine

    Directory of Open Access Journals (Sweden)

    Novitasari Dwi

    2016-01-01

    Full Text Available Indonesia has abundant potentials of new and renewable energy that can be used for electricity generation, especially in rural areas which have no access for grid electricity yet. The energy resources can be from solar, water, biomass or biofuel. Many villagers still use diesel generators to produce electricity in their villages. It is considered expensive because fuel price in rural areas increases 2-3 times than the normal price due to transportation cost. Hybrid system using renewable energy resources is one of the solutions to produce electricity in affordable cost for rural area. The idea is to combine diesel generators and photovoltaic toproduce electricity. Moreover, the diesel engine fuel can be replaced with biofuel. This study will analyze the hybrid system in a small scale which consists of 1kWp photovoltaic and 3 kW diesel engine. Electric load power will vary. The system is controlled by a single bidirectional inverter whichconverts power from DC to AC and vice versa

  15. Micro-macro hybrid soft-lithography master (MMHSM) fabrication for lab-on-a-chip applications.

    Science.gov (United States)

    Park, Jaewon; Li, Jianrong; Han, Arum

    2010-04-01

    We present a novel micro-macro hybrid soft-lithography master (MMHSM) fabrication technique where microdevices having both microscale and macroscale features can be replicated with a single soft-lithography step. A poly(methyl methacrylate) (PMMA) master having macroscale structures was first created by a bench-top milling machine. An imprinting master mold having microscale structures was then imprinted on the PMMA surface through a hot-embossing process to obtain a PMMA master mold. A poly(dimethylsiloxane) (PDMS) master was then replicated from this PMMA master through a standard soft-lithography process. This process allowed both microscale (height: 3-20 microm, width: 20-500 microm) and macroscale (height: 3.5 mm, width: 1.2-7 mm) structures to co-exist on the PDMS master mold, from which final PDMS devices could be easily stamped out in large quantities. Microfluidic structures requiring macroscale dimensions in height, such as reservoirs or fluidic tubing interconnects, could be directly built into PDMS microfluidic devices without the typically used manual punching process. This significantly reduced alignment errors and time required for such manual fabrication steps. In this paper, we successfully demonstrated the utility of this novel hybrid fabrication method by fabricating a PDMS microfluidic device with 40 built-in fluidic interfaces and a PDMS multi-compartment neuron co-culture platform, where millimeter-scale compartments are connected via arrays of 20 microm wide and 200 microm long microfluidic channels. The resulting structures were characterized for the integrity of the transferred pattern sizes and the surface roughness using scanning electron microscopy and optical profilometry.

  16. 光刻投影物镜中的透镜X-Y柔性微动调整机构%Flexure-based X-Y micro-motion mechanism used in lithographic lens

    Institute of Scientific and Technical Information of China (English)

    赵磊; 巩岩; 赵阳

    2013-01-01

    A novel X-Y micro-motion mechanism was proposed based on a flexure hinge to meet the demand of the lithographic lens for X-Y adjusting mechanism with a small range and a high precision,then it was applied to the lithographic lens model to testify its performance.Firstly,the working principle of the mechanism was introduced based on the concept of mechanism degree of freedom(DOF) and instant center.Then,the structure of the mechanism was designed by using the flexure hinge instead of tradition hinge and the motion rigidity of mechanism,the ratio of input and output for displacement and its natural frequency and modes were all analyzed.The analysis results show that the rigidity values of mechanism X and Y are 1.99 μm/N and 1.96 μm/N respectively,the ratio of input and output for displacement in X and Y axes are-2.5 and-2.56,respectively,and the principle errors in X and Y axes are 8.22% and 6.68%,respectively of its useful displacement.Finally,the mechanism was used in the lithographic lens systems to prove its performance,and the wavefront aberrations of the lens system were tested.The experiment results indicate that the wavefront aberrations of the systems before and after the mechanism adjusting compensations are 50.864 nm and 25.933 nm respectively.The X-Y flexural mechanism has good performance of aberration compensation,and it can satisfy the requirements of lithographic lens for high precision X-Y micro adjusting.%针对光刻投影物镜中透镜X-Y调整机构调整量程小、调整精度高的特点,提出了一种基于柔性铰链的X-Y微动调整机构,并将其应用在光刻投影物镜模型中进行了实验验证.首先,基于机构自由度和机构瞬心等概念介绍了该机构的工作原理.然后,用柔性铰链代替传统铰链完成了该机构的结构设计,并对该机构的运动方向刚度、位移输入-输出比以及固有频率和阵型等进行了仿真分析.分析结果表明:该机构X,y方向的刚度值为1.99

  17. Caracterização citogenética, viabilidade de pólen e hibridação artificial em gérbera Chromosome number, pollen viability and gerbera hybridization

    Directory of Open Access Journals (Sweden)

    Raquel DL Cardoso

    2009-03-01

    Full Text Available Este trabalho foi conduzido com o objetivo de confirmar o número de cromossomos em cultivares de Gerbera hybrida Hort., determinar o número de cromossomos em acessos não comerciais de Gerbera sp., avaliar a viabilidade de pólen e a possibilidade de cruzamentos entre cultivares e acessos não comerciais. Foram coletados ápices de raízes e pólen de seis cultivares e de sete acessos não comerciais. O material coletado foi corado com carmim acético a 45%. A contagem dos cromossomos foi realizada em células metafásicas intactas e a estimativa de viabilidade de pólen realizada por meio da contagem do número de grãos de pólen viáveis e não viáveis. A possibilidade de cruzamento entre as cultivares e entre as cultivares e acessos não comerciais foi avaliada por meio da hibridação entre os genitores femininos, cv. Terra Fame e acesso A8, e masculinos, cvs. Cariba e Azteca. Todos os acessos contiveram cinqüenta cromossomos, indicando que a variação morfológica nos capítulos (simples, semidobrado e dobrado não é devida a mutações cromossômicas numéricas ou a poliploidia. A viabilidade do pólen variou de 87,67% a 99,27%. A formação de sementes foi de 4,46% nos cruzamentos entre cultivares, e de 50% entre o A8 e as cultivares. A compatibilidade genômica entre os acessos, a alta viabilidade do pólen e o sucesso na obtenção de sementes entre acessos comercias e não comerciais, revela a possibilidade de produção de híbridos com novas combinações alélicas e transferência de caracteres desejáveis dos acessos não comerciais para os comerciaisThis work was conducted to confirm the chromosomes number of Gerbera hybrida Hort. cultivars, to determine the chromosomes number in the non commercial accessions of Gerbera sp., and to estimate the pollen viability and the possibility of crossings among different accessions. Root-tip and pollen were collected from six cultivars and seven non commercial accessions. The collected

  18. Electrochemical hydrogen evolution of multi-walled carbon nanotube/micro-hybrid composite decorated with Ni nanoparticles as catalyst through electroless deposition process.

    Science.gov (United States)

    Rahimi, Nazanin; Doroodmand, Mohammad Mahdi; Sabbaghi, Samad; Sheikhi, Mohammad Hossein

    2013-08-01

    Hydrogen evolution of multi-walled nanotube (MWCNT)/micro-hybrid polymer composite, decorated with Ni nanoparticles through electroless deposition process is studied by the electrochemical method. Cyclic voltammetry (CV) is utilized to clearly study the electrochemical hydrogen storage/evolution behavior of the composite through a potential window ranging from -1.60 to +0.60 V (vs. Ag/AgCl). Hydrogen adsorption/desorption peaks are positioned at -1.52 and -0.05 V, respectively. Chronoamperometry is also applied to estimate active surface area (0.145 m(2)g(-1)) of the composite as well as the diffusion coefficient (3.4×10(-11) m(2) s(-1)) of adsorbed hydrogen process. According to the chrono-charge/discharge technique, the capacity of fabricated Ni-MWCNT/micro-hybrid composite is estimated to be 2.98 wt.% during charging for a certain time (40 min).

  19. Characterization of electrochemical response of a hybrid micro-nanochannel system using computational impedance spectroscopy (CIS)

    Science.gov (United States)

    Nandigana, Vishal; Aluru, Narayan

    2013-11-01

    Single molecule/particle sensing using micro/nanochannel integrated systems has attracted tremendous interest in recent years. The molecule in an aqueous ionic solution is translocated from the source microchannel towards the drain microchannel across a nanochannel under the influence of an external electric field. The translocated molecules are characterized from the electrical response of the system. In order to develop an efficient design for accurate characterization of single molecules, it is important to first understand the ion-transport dynamics in these integrated systems. To this end, we develop a computationally efficient area-averaged multi-ion transport model (AAM), considering an ion-selective nanochannel integrated with a microchannel on either side. Further, we study the ion transport dynamics both under equilibrium and non-equilibrium regimes. In each regime, the base state is perturbed with an external harmonic electrical disturbance over a wide range of frequency spectrum and the electrochemical impedance response is computed. We correlate each characteristic frequency present in the system to its corresponding physical phenomena and also characterize the microscopic diffusion boundary layer lengths (DBL) observed in the microchannel. This work was supported by the National Science Foundation (NSF) under Grants 0328162 (nano-CEMMS, UIUC), 0852657 and 0915718.

  20. Micro-mechanics of nanostructured carbon/shape memory polymer hybrid thin film.

    Science.gov (United States)

    Lei, Ming; Xu, Ben; Pei, Yutao; Lu, Haibao; Fu, Yong Qing

    2016-01-01

    This paper investigates the mechanics of hybrid shape memory polymer polystrene (PS) based nanocomposites with skeletal structures of CNFs/MWCNTs formed inside. Experimental results showed an increase of glass transition temperature (Tg) with CNF/MWCNT concentrations instead of a decrease of Tg in nanocomposites filled by spherical particles, and an increase in mechanical properties on both macro- and μm-scales. Compared with CNFs, MWCNTs showed a better mechanical enhancement for PS nanocomposites due to their uniform distribution in the nanocomposites. In nanoindentation tests using the Berkovich tips, indentation size effects and pile-up effects appeared obviously for the nanocomposites, but not for pure PS. Experimental results revealed the enhancement mechanisms of CNFs/MWCNTs related to the secondary structures formed by nanofillers, including two aspects, i.e., filler-polymer interfacial connections and geometrical factors of nanofillers. The filler-polymer interfacial connections were strongly dependent on temperature, thus leading to the opposite changing trend of loss tangent with nanofiller concentrations, respectively, at low and high temperature. The geometrical factors of nanofillers were related to testing scales, further leading to the appearance of pile-up effects for nanocomposites in the nanoindentation tests, in which the size of indents was close to the size of the nanofiller skeleton.

  1. The Institutional Cost of Being a Professor of Color: Unveiling Micro-Aggression, Racial [In]visibility, and Racial Profiling through the Lens of Critical Race Theory

    Science.gov (United States)

    Orelus, Pierre Wilbert

    2013-01-01

    Drawing on critical race theory, auto-ethnography, and resistant narratives, this article examines systemic forms of oppression that professors of color teaching at predominantly white institutions have been facing. The author incorporates in his analysis his experience as a faculty of color battling multiple forms of micro-aggression (Solorzano,…

  2. A Novel Ion-exchange Method for the Synthesis of Nano-SnO/micro-C Hybrid Structure as High Capacity Anode Material in Lithium Ion Batteries

    Institute of Scientific and Technical Information of China (English)

    Zhi Tan; Zhenhua Sun; Qi Guo; Haihua Wang; Dangsheng Su

    2013-01-01

    A novel and simple ion-exchange method was developed for the synthesis of nano-SnO/micro-C hybrid structure.The structure of the as prepared nano-SnO/micro-C was directly revealed by scanning electron microscopy (SEM)and transmission electron microscopy (TEM).SnO particles with the size about 25 nm were well confined in amorphous carbon microparticles.Carbon matrix in micrometer scale not only acts as a protective buffer for the SnO nanoparticles during the battery cycling processes,but also avoids the shortcomings of nanostructures,such as low tap density and potential safety threats.Electrochemical behaviors of the nano-SnO/micro-C were tested as anode material in lithium ion batteries.The initial reversible capacity is 508 mA h g-1,and the reversible capacity after 60 cycles is 511 mA h g-1,indicating good capacity retention ability.

  3. Environmental standards for intraocular lens implantation.

    Science.gov (United States)

    Crawford, B A; Kaufman, D V

    1984-02-01

    Successful implantation of prosthetic devices depends upon their freedom from postoperative inflammation and infection. Techniques and lessons learned in orthopaedic and other implant surgery should be applied to intraocular lens implantation. The avoidance of contamination by particles and micro-organisms is one essential principle of the surgical procedure. Practical steps are described to reduce both types of contamination. These measures taken together are recommended for adoption as a standard of environmental safety for lens implantation.

  4. Evaluation of structural and mechanical properties of electrospun nano-micro hybrid of poly hydroxybutyrate-chitosan/silk scaffold for cartilage tissue engineering.

    Science.gov (United States)

    Karbasi, Saeed; Fekrat, Farnoosh; Semnani, Daryoush; Razavi, Shahnaz; Zargar, Elham Naghash

    2016-01-01

    One of the new methods of scaffold fabrication is a nano-micro hybrid structure in which the properties of the scaffold are improved by introducing nanometer and micrometer structures. This method could be suitable for scaffold designing if some features improve. In this study, electrospun nanofibers of 9% weight solution of poly (3-hydroxybutyrate) (P3HB) and a 15% weight of chitosan by trifluoroacetic acid were coated on both the surface of a silk knitted substrate in the optimum condition to improve the mechanical properties of scaffolds for cartilage tissue engineering application. These hybrid nano-micro fibrous scaffolds were characterized by structural and mechanical evaluation methods. Scanning electron microscopy values and porosity analysis showed that average diameter of nanofibers was 584.94 nm in electrospinning part and general porosity was more than 80%. Fourier transform infrared spectroscopy results indicated the presence of all elements without pollution. The tensile test also stated that by electrospinning, as well as adding chitosan, both maximum strength and maximum elongation increased to 187 N and 10 mm. It means that the microfibrous part of scaffold could affect mechanical properties of nano part of the hybrid scaffold, significantly. It could be concluded that P3HB-chitosan/silk hybrid scaffolds can be a good candidate for cartilage tissue engineering.

  5. Reliability of hybrid photovoltaic DC micro-grid systems for emergency shelters and other applications

    Science.gov (United States)

    Dhere, Neelkanth G.; Schleith, Susan

    2014-10-01

    Improvement of energy efficiency in the SunSmart Schools Emergency Shelters requires new methods for optimizing the energy consumption within the shelters. One major limitation in current systems is the requirement of converting direct current (DC) power generated from the PV array into alternating current (AC) power which is distributed throughout the shelters. Oftentimes, this AC power is then converted back to DC to run certain appliances throughout the shelters resulting in a significant waste of energy due to DC to AC and then again AC to DC conversion. This paper seeks to extract the maximum value out of PV systems by directly powering essential load components within the shelters that already run on DC power without the use of an inverter and above all to make the system reliable and durable. Furthermore, additional DC applications such as LED lighting, televisions, computers and fans operated with DC brushless motors will be installed as replacements to traditional devices in order to improve efficiency and reduce energy consumption. Cost of energy storage technologies continue to decline as new technologies scale up and new incentives are put in place. This will provide a cost effective way to stabilize the energy generation of a PV system as well as to provide continuous energy during night hours. It is planned to develop a pilot program of an integrated system that can provide uninterrupted DC power to essential base load appliances (heating, cooling, lighting, etc.) at the Florida Solar Energy Center (FSEC) command center for disaster management. PV arrays are proposed to be installed on energy efficient test houses at FSEC as well as at private homes having PV arrays where the owners volunteer to participate in the program. It is also planned to monitor the performance of the PV arrays and functioning of the appliances with the aim to improve their reliability and durability. After a successful demonstration of the hybrid DC microgrid based emergency

  6. Iron oxide functionalized graphene oxide as an efficient sorbent for dispersive micro-solid phase extraction of sulfadiazine followed by spectrophotometric and mode-mismatched thermal lens spectrometric determination.

    Science.gov (United States)

    Kazemi, Elahe; Dadfarnia, Shayessteh; Haji Shabani, Ali Mohammad; Abbasi, Amir; Rashidian Vaziri, Mohammad Reza; Behjat, Abbas

    2016-01-15

    A simple and rapid dispersive micro-solid phase extraction (DMSPE) combined with mode-mismatched thermal lens spectrometry as well as fiber optic linear array spectrophotometry was developed for the separation, extraction and determination of sulfadiazine. Graphene oxide was synthesized using the modified Hummers method and functionalized with iron oxide nanoparticles by means of a simple one step chemical coprecipitation method. The synthesized iron oxide functionalized graphene oxide was utilized as an efficient sorbent in DMSPE of sulfadiazine. The retained analyte was eluted by using 180µL of a 6:4 mixture of methanol/acetic acid solution and was spectrophotometrically determined based on the formation of an azo dye through coupling with thenoyltrifluoroacetone. Under the optimized conditions, with the application of spectrophotometry technique and with a sample volume of 100mL, the method exhibited a linear dynamic range of 3-80µg L(-1) with a detection limit of 0.82µg L(-1), an enrichment factor of 200 as well as the relative standard deviations of 2.6% and 4.3% (n=6) at 150µg L(-1) level of sulfadiazine for intra- and inter-day analyses, respectively. Whereas, through the application of the thermal lens spectrometry and a sample volume of 10mL, the method exhibited a linear dynamic range of 1-800µg L(-1) with a detection limit of 0.34µg L(-1) and the relative standard deviations of 3.1% and 5.4% (n=6) at 150µg L(-1) level of sulfadiazine for intra- and inter-day analyses, respectively. The method was successfully applied to the determination of sulfadiazine in milk, honey and water samples.

  7. Design and part-load performance of a hybrid system based on a solid oxide fuel cell reactor and a micro gas turbine

    Science.gov (United States)

    Costamagna, P.; Magistri, L.; Massardo, A. F.

    This paper addresses the design and off-design analysis of a hybrid system (HS) based on the coupling of a recuperated micro gas turbine (MGT) with a high temperature solid oxide fuel cell (SOFC) reactor. The SOFC reactor model is presented and discussed, taking into account the influence of the reactor lay-out, the current density, the air utilisation factor, the cell operating temperature, etc. The SOFC design and off-design performance is presented and discussed; the design and off-design models of a recuperated micro-gas turbine are also presented. The operating line, the influence of the micro gas turbine "variable speed" control, and the efficiency behaviour at part load are analysed in depth. Finally, the model of the hybrid system obtained by coupling the MGT and the SOFC reactor, considering the compatibility (technological constraints) of the two systems, is presented. The model allows the evaluation of the design and off-design behaviour of the hybrid system, particularly when the MGT variable speed control system is considered. The thermal efficiency of the hybrid system, taking into account its size (250/300 kW e), is noteworthy: higher than 60% at design point, and also very high at part load conditions. Such a result is mainly due to the simultaneous positive influence of SOFC off-design behaviour and MGT variable speed control. Moreover, it is possible to recover the waste heat from the gas at the MGT recuperator outlet ( Tgas is about 250°C) for cogeneration purposes.

  8. Hybrid Energy Cell with Hierarchical Nano/Micro-Architectured Polymer Film to Harvest Mechanical, Solar, and Wind Energies Individually/Simultaneously.

    Science.gov (United States)

    Dudem, Bhaskar; Ko, Yeong Hwan; Leem, Jung Woo; Lim, Joo Ho; Yu, Jae Su

    2016-11-09

    We report the creation of hybrid energy cells based on hierarchical nano/micro-architectured polydimethylsiloxane (HNMA-PDMS) films with multifunctionality to simultaneously harvest mechanical, solar, and wind energies. These films consist of nano/micro dual-scale architectures (i.e., nanonipples on inverted micropyramidal arrays) on the PDMS surface. The HNMA-PDMS is replicable by facile and cost-effective soft imprint lithography using a nanoporous anodic alumina oxide film formed on the micropyramidal-structured silicon substrate. The HNMA-PDMS film plays multifunctional roles as a triboelectric layer in nanogenerators and an antireflection layer for dye-sensitized solar cells (DSSCs), as well as a self-cleaning surface. This film is employed in triboelectric nanogenerator (TENG) devices, fabricated by laminating it on indium-tin oxide-coated polyethylene terephthalate (ITO/PET) as a bottom electrode. The large effective contact area that emerged from the densely packed hierarchical nano/micro-architectures of the PDMS film leads to the enhancement of TENG device performance. Moreover, the HNMA-PDMS/ITO/PET, with a high transmittance of >90%, also results in highly transparent TENG devices. By placing the HNMA-PDMS/ITO/PET, where the ITO/PET is coated with zinc oxide nanowires, as the top glass substrate of DSSCs, the device is able to add the functionality of TENG devices, thus creating a hybrid energy cell. The hybrid energy cell can successfully convert mechanical, solar, and wind energies into electricity, simultaneously or independently. To specify the device performance, the effects of external pushing frequency and load resistance on the output of TENG devices are also analyzed, including the photovoltaic performance of the hybrid energy cells.

  9. Small RNA in situ hybridization in Caenorhabditis elegans, combined with RNA-seq, identifies germline-enriched microRNAs.

    Science.gov (United States)

    McEwen, Tamara J; Yao, Qiuming; Yun, Sijung; Lee, Chin-Yung; Bennett, Karen L

    2016-10-15

    Over four hundred different microRNAs (miRNAs) have been identified in the genome of the model organism the nematode Caenorhabditis elegans. As the germline is dedicated to the preservation of each species, and almost half of all the cells in an adult nematode are germline, it is likely that regulatory miRNAs are important for germline development and maintenance. In C. elegans the miR35 family has strong maternal effects, contributing to normal embryogenesis and to adult fecundity. To determine whether any particular miRNAs are greatly enriched in the C. elegans germline we used RNA-seq to compare the miRNA populations in several germline-defective strains of adult C. elegans worms, including glp-4(germline proliferation-4), glh-1(germline helicase-1) and dcr-1(dicer-1). Statistical analyses of RNA-seq comparisons identified 13 miRNAs that are germline-enriched, including seven members of the well-studied miR35 family that were reduced as much as 1000-fold in TaqMan qRT PCR miRNA assays. Along with the miR35s, six others: miR-56 (a member of the miR51 family),-70, -244, -260 , -788 and -4813, none of which previously considered as such, were also identified by RNA-seq as germline-enriched candidates. We went on to develop a successful miRNA in situ hybridization protocol for C. elegans, revealing miR35s specifically concentrate during oogenesis in the pachytene region of the gonad, and persist throughout early embryogenesis, while in adult animals neither let-7 nor miR-228 has a germline-bias.

  10. Hybridizing micro-Ti with nano-B4C particulates to improve the microstructural and mechanical characteristics of Mg–Ti composite

    Directory of Open Access Journals (Sweden)

    S. Sankaranarayanan

    2014-03-01

    Full Text Available In this study, the effects of hybridizing micron-sized titanium particles with nano-sized boron carbide particles on the microstructural and mechanical properties of Mg–Ti composite were investigated. Microstructural characterization revealed grain refinement attributed to the presence of uniformly distributed micro-Ti particles embedded with nano-B4C particulates. Electron back scattered diffraction (EBSD analyses of the Mg–(Ti + B4CBM hybrid composite showed relatively more localized recrystallized grains and lesser tensile twin fraction, when compared to Mg–Ti. The evaluation of mechanical properties indicated that the best combination of strength and ductility was observed in the Mg–(Ti + B4CBM hybrid composite. The superior properties of the Mg–(Ti + B4CBM hybrid composite when compared to Mg–Ti can be attributed to the presence of nano-reinforcement, the uniform distribution of the hybridized particles and the better interfacial bonding between the matrix and the reinforcement particles achieved by nano-B4C addition.

  11. Transient Oscillations Analysis and Modified Control Strategy for Seamless Mode Transfer in Micro-Grids: A Wind-PV-ES Hybrid System Case Study

    Directory of Open Access Journals (Sweden)

    Tengfei Zhang

    2015-12-01

    Full Text Available With the rapid development of the micro-grid associated with new and clean energies, the smooth switching between grid-connected and islanded operation modes of the micro-grid is a key issue that needs to be addressed urgently. In traditional solutions, V/f (Voltage/frequency control is adopted for the master micro sources when the micro-grid works in islanded mode, while PQ (real and reactive power control is adopted when in grid-connected mode. However, when the two controllers switch when mode transfer occurs, transient oscillations usually occur and thereafter the dynamic response will be degraded. This paper considers an archetypical micro-grid with Wind-PV-ES (Wind, Photovoltaic and Energy Storage hybrid system, which forms the basis of our case study. The underlying reason for such transient oscillation is analyzed in this paper. Thereafter a modified control strategy for seamless mode transfer is designed and implemented. An improved PQ control method is designed by which the output of the PQ controller always synchronously tracks the output of the V/f controller for micro-grid switches from islanded mode to grid-connected; furthermore, a dq rotating coordinate synchronization based V/f control method is proposed for transition from grid-connected mode to islanded mode. Finally, experiments and analysis are undertaken on some basic and important operating cases; the results in our case study indicate that the modified control strategy is effective in dominating the micro-grid during mode transfer and thus yielding significantly better performances.

  12. Development of a fluorescence in situ hybridization protocol for the identification of micro-organisms associated with wastewater particles and flocs.

    Science.gov (United States)

    Ormeci, Banu; Linden, Karl G

    2008-11-01

    Fluorescence in situ hybridization (FISH) provides a unique tool to study micro-organisms associated with particles and flocs. FISH enables visual examination of micro-organisms while they are structurally intact and associated with particles. However, application of FISH to wastewater and sludge samples presents a specific set of problems. Wastewater samples generate high background fluorescence due to their organic and inorganic content making it difficult to differentiate a probe-conferred signal from naturally fluorescing particles with reasonable certainty. Furthermore, some of the FISH steps involve harsh treatment of samples, and are likely to disrupt the floc structure. This study developed a FISH protocol for studying micro-organisms that are associated with particles and flocs. The results indicate that choice of a proper fluorochrome and labeling technique is a key step in reducing the background fluorescence and non-specific binding, and increasing the intensity of the probe signal. Compared to other fluorochromes tested, CY3 worked very well and enabled the observation of particles and debris in red and probe signal from microbes in yellow. Fixation, hybridization, and washing steps disturbed the floc structure and particle-microbe association. Modifications to these steps were necessary, and were achieved by replacing centrifugation with filtration and employment of nylon filters. Microscope slides generated excellent quality images, but polycarbonate membrane filters performed better in preserving the floc structure.

  13. rs78378222 polymorphism in the 3'-untranslated region of TP53 contributes to development of age-associated cataracts by modifying microRNA-125b-induced apoptosis of lens epithelial cells.

    Science.gov (United States)

    Zhao, Yang; Li, Xiao; Zhu, Siquan

    2016-09-01

    MicroRNAs (miRNAs) negatively regulate the expression of the target genes by binding to 'seed sequences' in the 3'‑untranslated region (3'‑UTR) mRNA transcripts, and the variants within or nearby 'seed sequences' may compromise or enhance miRNA/mRNA interaction leading to either 'loss‑of‑function' or 'gain‑of‑function' effects. Cataracts are the leading cause of blindness worldwide and are characterized by progressive aggregation and precipitation of lens proteins, and the development of age‑related cataracts is associated with dysregulated cellular activities of lens epithelial cells. Luciferase assays and online miRNA databases were used to validate that tumor protein p53 (TP53) is the target gene of miR‑125b. Furthermore, reverse transcription‑quantitative polymerase chain reaction and western blotting were conducted to detect expression levels of miR‑125b and TP53 in different groups of cells transfected with miR‑125b mimics or inhibitors. In addition, flow cytometry analysis and the MTT assay were conducted to detect the effects of miR‑125b on apoptosis and cell viability. The current study demonstrated that the rs78378222 polymorphism minor allele introduces a novel potential miR‑125b binding site in the TP53 3'‑UTR with a consecutive 8‑bp perfect match, creating a 'gain‑of‑function' variant and affecting the regulation of TP53 expression. A luciferase assay demonstrated that transfection of lens epithelial cells with wild type TP53 3'‑UTR significantly reduced the luciferase activity of the miR‑125b overexpressing cells compared with scramble controls. In addition, the luciferase activity of miR‑125b overexpressing cells transfected with the construct containing the rs78378222 polymorphism minor allele was also reduced compared with cells transfected with the wild type 3'‑UTR. Furthermore, it was demonstrated that the expression level of miR‑125 was comparable in epithelial cells from patients with age

  14. Lente de contato de material híbrido em pacientes com ceratocone e astigmatismo miópico composto Hybrid material contact lens in keratoconus and myopic astigmatism patients

    Directory of Open Access Journals (Sweden)

    Fernando Leal

    2007-03-01

    óculos, exceto para a freqüência B (3 cpg, maior nos usuários de óculos. As aberrações de alta ordem analisadas apresentaram diminuição estatisticamente significante, quando comparados os pacientes sem e com uso de lentes de contato, com exceção da aberração esférica e do coma. CONCLUSÃO: A lente de contato de material híbrido, quando utilizada por portadores de ceratocone e astigmatismo miópico composto, propiciaram desempenho visual e conforto satisfatórios, em níveis que não diferiram, das lentes de contato rígidas-gás-permeáveis nos dois grupos de pacientes.PURPOSE: To evaluate comfort and visual performance in relation to two different used contact lens types: hybrid material (HM and rigid-gas-permeable (RGP, in patients with regular myopic astigmatism and with keratoconus. METHODS: A randomized, double masked, prospective study of 22 patients with the diagnosis of myopic astigmatism (8 with myopic astigmatism and 14 with keratoconus was conducted. Fifteen patients were female and 7 were male, and mean age was: 32.13 ± 8.12 years. In one of the eyes a rigid-gas-permeable contact lens was adapted (DK 30, and in the other a hybrid material contact lens was adapted (DK 23. All patients were submitted to the following tests: measurement of comfort level by means of the analogical visual scale, tear break-up time, best corrected visual acuity with the Bailey-Lovie scale adapted for 4 meters, functional acuity contrast test (FACT and wavefront analysis. RESULTS: In relation to comfort, there was no association with the evaluated contact lens type (p=0.350. There was a variation in comfort level during the first 7 days. The visual acuity increased between the 7th and the 15th day of adaptation. Visual acuity stabilized right after this period. The visual acuity did not show differences in relation to the studied lens type. It was verified that there was no difference in the tear break-up time (p=0.989 in relation to the studied lenses type and

  15. Micro-hybrid electric vehicle application of valve-regulated lead-acid batteries in absorbent glass mat technology: Testing a partial-state-of-charge operation strategy

    Science.gov (United States)

    Schaeck, S.; Stoermer, A. O.; Hockgeiger, E.

    The BMW Group has launched two micro-hybrid functions in high volume models in order to contribute to reduction of fuel consumption in modern passenger cars. Both the brake energy regeneration (BER) and the auto-start-stop function (ASSF) are based on the conventional 14 V vehicle electrical system and current series components with only little modifications. An intelligent control algorithm of the alternator enables recuperative charging in braking and coasting phases, known as BER. By switching off the internal combustion engine at a vehicle standstill the idling fuel consumption is effectively reduced by ASSF. By reason of economy and package a lead-acid battery is used as electrochemical energy storage device. The BMW Group assembles valve-regulated lead-acid (VRLA) batteries in absorbent glass mat (AGM) technology in the micro-hybrid electrical power system since special challenges arise for the batteries. By field data analysis a lower average state-of-charge (SOC) due to partial state-of-charge (PSOC) operation and a higher cycling rate due to BER and ASSF are confirmed in this article. Similar to a design of experiment (DOE) like method we present a long-term lab investigation. Two types of 90 Ah VRLA AGM batteries are operated with a test bench profile that simulates the micro-hybrid vehicle electrical system under varying conditions. The main attention of this lab testing is focused on capacity loss and charge acceptance over cycle life. These effects are put into context with periodically refresh charging the batteries in order to prevent accelerated battery aging due to hard sulfation. We demonstrate the positive effect of refresh chargings concerning preservation of battery charge acceptance. Furthermore, we observe moderate capacity loss over 90 full cycles both at 25 °C and at 3 °C battery temperature.

  16. Recent advances with a hybrid micro-pattern gas detector operated in low pressure H2 and He, for AT-TPC applications

    CERN Document Server

    Cortesi, Marco; Bazin, Daniel; Beceiro-Novo, Saul; Yurkon, John; Tanani, Rim Soussi; Wolff, Michael; Stolz, Andreas

    2015-01-01

    In view of a possible application as a charge-particle track readout for an Active-Target Time Projection Chamber (AT-TPC), the operational properties and performances of a hybrid Micro-Pattern Gaseous Detector (MPGD) were investigated in pure low-pressure Hydrogen (H2) and Helium (He). The detector consists of a MICROMesh GAseous Structure (MICROMEGAS) coupled to a single- or multi-cascade THick Gaseous Electron Multiplier (THGEM) as a pre-amplification stage. This study reports of the effective gain dependence of the hybrid-MPGD at relevant pressure (in the range of 200-760 torr) for different detector arrangements. The results of this work are relevant in the field of avalanche mechanism in low-pressure, low-mass noble gases, in particularly for applications of MPGD end-cap readout for active-target Time Projection Chambers (TPC) in the field of nuclear physics and nuclear astrophysics.

  17. Design and application of a technologically explicit hybrid energy-economy policy model with micro and macro economic dynamics

    Science.gov (United States)

    Bataille, Christopher G. F.

    2005-11-01

    Are further energy efficiency gains, or more recently greenhouse gas reductions, expensive or cheap? Analysts provide conflicting advice to policy makers based on divergent modelling perspectives, a 'top-down/bottom-up debate' in which economists use equation based models that equilibrate markets by maximizing consumer welfare, and technologists use technology simulation models that minimize the financial cost of providing energy services. This thesis summarizes a long term research project to find a middle ground between these two positions that is more useful to policy makers. Starting with the individual components of a behaviourally realistic and technologically explicit simulation model (ISTUM---Inter Sectoral Technology Use Model), or "hybrid", the individual sectors of the economy are linked using a framework of micro and macro economic feedbacks. These feedbacks are taken from the economic theory that informs the computable general equilibrium (CGE) family of models. Speaking in the languages of both economists and engineers, the resulting "physical" equilibrium model of Canada (CIMS---Canadian Integrated Modeling System), equilibrates energy and end-product markets, including imports and exports, for seven regions and 15 economic sectors, including primary industry, manufacturing, transportation, commerce, residences, governmental infrastructure and the energy supply sectors. Several different policy experiments demonstrate the value-added of the model and how its results compare to top-down and bottom-up practice. In general, the results show that technical adjustments make up about half the response to simulated energy policy, and macroeconomic demand adjustments the other half. Induced technical adjustments predominate with minor policies, while the importance of macroeconomic demand adjustment increases with the strength of the policy. Results are also shown for an experiment to derive estimates of future elasticity of substitution (ESUB) and

  18. Influência da quantidade de pólen na produção e qualidade de sementes híbridas de abóbora Influence of pollen amount on production and quality of squash hybrid seeds

    Directory of Open Access Journals (Sweden)

    WM Nascimento

    2011-03-01

    Full Text Available A baixa produção de sementes híbridas de abóbora obtida em nossas condições deve-se provavelmente aos métodos de produção pouco eficientes. A quantidade de pólen transferido naturalmente ou artificialmente entre os parentais pode afetar não só a produção como também a qualidade das sementes híbridas. Neste estudo, utilizou-se a polinização manual, a qual constou de cinco tratamentos relacionados com a quantidade de pólen do progenitor masculino para polinizar uma única flor feminina: um quarto da quantidade de pólen de uma flor; metade da quantidade de pólen de uma flor; a quantidade de pólen de uma flor; a quantidade de pólen de duas flores, e a quantidade de pólen de quatro flores masculinas. O delineamento experimental adotado foi em blocos ao acaso, com três repetições e dezoito plantas por parcela. O aumento da quantidade de pólen aplicada aumentou a produção de sementes por fruto e consequentemente a produção de sementes por área. A qualidade fisiológica das sementes praticamente não foi afetada entre os tratamentos, embora foi observada uma menor germinação das sementes obtidas em frutos provenientes de flores polinizadas com 1/4 de pólen.The low production of squash hybrid seeds obtained in our conditions is probably due to the inefficient production methods. The amount of pollen transferred naturally or artificially between the two parents may affect not only the hybrid seed production but also the seed quality of squash. In this study, flowers were manually pollinated using five amounts of pollen to pollinate one female flower: 1/4 of pollen from one flower; half of the amount of pollen from one flower; pollen of one flower; pollen of two flowers and pollen of four flowers. The randomized complete block design was adopted, with three replications and eighteen plants per plot. The increasing pollen amount affected significantly seed yield per fruit and seed yield per area, but did not influence

  19. Hybrid Refractive-Diffractive Achromatic System Design with Photon Sieve-Lens Combination%光子筛-透镜组合的折衍混合消色差系统设计

    Institute of Scientific and Technical Information of China (English)

    何渝; 赵立新; 唐燕; 陈铭勇; 朱江平

    2012-01-01

    Photon sieve is a diffractive optical element with large chromatic aberration, which is not suitable for imaging in wide spectral. The focal length of photon sieve decreases when the incident wavelength increases, while the focal length of positive refractive lens increases when the incident wavelength increases. The design applying the method of hybrid refractive-diffractive into the photon sieve achromatic is proposed. These opposite dispersive characteristics are used in this method. A plano-convex len is placed close to side of a photon sieve in order to achieve achromatic design. Then the achromatic system is designed in the visible spectrum. The analysis shows that the system is achromatic and has a certain ability of secondary spectrum correction. The relative error between focal lengths of achromatic wavelength and centre wavelength is 0. 33%. The imaging spectral bandwidth is 20 nm. Compared with ordinary single photon sieve, the design broadens the imaging spectrum range. Compared with the hybrid refractive-diffractive system using zone plate, a smaller focusing spot can be achieved.%光子筛作为一种衍射光学元件,具有较大的色散,不适用于宽光谱成像.光子筛的焦距随着入射波长的增大而减小,而正的折射透镜焦距随着入射波长的增大而增大.应用了折衍混合方法进行光子筛消色差的设计.该设计利用二者相反的色散特性,在光子筛的一侧紧密放置一平凸透镜,从而实现光子筛的消色差设计.并针对可见光光谱进行了设计,分析表明该方法能够实现消色差,且具有一定校正二级光谱的能力,消色差波长与中心波长处焦距相对误差为0.33%,成像光谱带宽为20 nm.与普通单个光子筛相比,该方法有效拓宽了光子筛的成像光谱范围.与使用波带片的折衍混合系统相比,聚焦光斑更小.

  20. Variable-focus cylindrical liquid lens array

    Science.gov (United States)

    Zhao, Wu-xiang; Liang, Dong; Zhang, Jie; Liu, Chao; Zang, Shang-fei; Wang, Qiong-hua

    2013-06-01

    A variable-focus cylindrical liquid lens array based on two transparent liquids of different refractive index is demonstrated. An elastic membrane divides a transparent reservoir into two chambers. The two chambers are filled with liquid 1 and liquid 2, respectively, which are of different refractive index. The micro-clapboards help liquid 1, liquid 2 and the elastic membrane form a cylindrical lens array. Driving these two liquids to flow can change the shape of the elastic membrane as well as the focal length. In this design, the gravity effect of liquid can be overcome. A demo lens array of positive optical power is developed and tested. Moreover, a potential application of the proposed lens array for autostereoscopic 3D displays is emphasized.

  1. Application of optical polymers in lens design

    Science.gov (United States)

    Sultanova, Nina; Kasarova, Stefka; Nikolov, Ivan

    2016-03-01

    Optical, some thermal and elastic properties of optical polymers which are of importance in lens design are considered. Results are based on precise measurement of refraction of materials. Ultrasonic investigation of elastic moduli is carried out. Comparison to properties of Schott glasses is accomplished. Examples on the design of all-plastic and hybrid glass-plastic systems are presented.

  2. Electromagnetic Mathematical Modeling of 3D Supershaped Dielectric Lens Antennas

    Directory of Open Access Journals (Sweden)

    L. Mescia

    2016-01-01

    Full Text Available The electromagnetic analysis of a special class of 3D dielectric lens antennas is described in detail. This new class of lens antennas has a geometrical shape defined by the three-dimensional extension of Gielis’ formula. The analytical description of the lens shape allows the development of a dedicated semianalytical hybrid modeling approach based on geometrical tube tracing and physical optic. In order to increase the accuracy of the model, the multiple reflections occurring within the lens are also taken into account.

  3. International joint development for demonstration by NEDO. `Research for demonstration of a solar power/micro hydro power bybrid system`; NEDO kokusai kyodo jissho kaihatsu `taiyoko micro suiryoku hybrid system jissho kenkyu`

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-01-10

    As part of the international joint development for demonstration by the New Energy and Industrial Technology Development Organization (NEDO) in fiscal 1997, a `research for demonstration of a solar power/micro hydro power bybrid system` was commissioned. A hybrid system was structured, which consists of a 100-kW class photovoltaic power generating equipment, a 25-kW class micro-hydro power generating equipment, and a battery set to store surplus power. Construction for system installation to perform demonstration operation was launched in Trang Village, Nang Yang Prefecture, Vietnam. This demonstration research is scheduled to execute system design and fabrication as well as the foundation construction for system installation in fiscal 1998, and the installation and adjustment will be completed by some time in the summer of 1999. Thereafter, demonstration operation will be performed for about two years with an objective to evaluate complementary relationship between the photovoltaic power generation and the micro-hydro power generation, the system economy, and electric power quality. (NEDO)

  4. International joint development for demonstration by NEDO. 'Research for demonstration of a solar power/micro hydro power bybrid system'. NEDO kokusai kyodo jissho kaihatsu 'taiyoko micro suiryoku hybrid system jissho kenkyu'

    Energy Technology Data Exchange (ETDEWEB)

    1999-01-10

    As part of the international joint development for demonstration by the New Energy and Industrial Technology Development Organization (NEDO) in fiscal 1997, a 'research for demonstration of a solar power/micro hydro power bybrid system' was commissioned. A hybrid system was structured, which consists of a 100-kW class photovoltaic power generating equipment, a 25-kW class micro-hydro power generating equipment, and a battery set to store surplus power. Construction for system installation to perform demonstration operation was launched in Trang Village, Nang Yang Prefecture, Vietnam. This demonstration research is scheduled to execute system design and fabrication as well as the foundation construction for system installation in fiscal 1998, and the installation and adjustment will be completed by some time in the summer of 1999. Thereafter, demonstration operation will be performed for about two years with an objective to evaluate complementary relationship between the photovoltaic power generation and the micro-hydro power generation, the system economy, and electric power quality. (NEDO)

  5. A Novel Method for Idle-Stop-Start Control of Micro Hybrid Construction Equipment—Part A: Fundamental Concepts and Design

    Directory of Open Access Journals (Sweden)

    Truong Quang Dinh

    2017-07-01

    Full Text Available Although micro hybrid propulsion (MHP systems are recognized as a feasible solution for off-highway construction machines (OHCMs, there is still a lack of understanding how existing MHP technologies can be transferred effectively from the automotive sector to the construction sector. To fill this gap, this paper is the first of a two-part study which focuses on micro hybrid construction machines paying attention to a novel idle-stop-start control (ISSC strategy. Part A presents the system concepts and design procedure while Part B studies on a hardware-in-the-loop test platform for a comprehensive analysis on the potential fuel/emission saving of the proposed system in real-time. In this study—Part A—different types of OHCMs are briefly discussed to identify the target machine. The procedure to model the machine powertrain is also concisely introduced. Next, to minimize the fuel consumption and emissions without degrading the machine performance, a prediction-based idle-stop-start control (PISSC approach is properly designed. The core of the PISSC is to estimate online the future engine working state changes in order to directly shut down the engine or shift it to low power regions during idle periods. Numerical simulations have been carried out to validate the potential of the proposed PISSC method.

  6. Viabilidade do grão de pólen de acessos de capim-elefante, milheto e híbridos interespecíficos (capim-elefante x milheto = Pollen viability in elephantgrass, pearl millet and interspecific hybrids (elephantgrass x pearl millet acessions

    Directory of Open Access Journals (Sweden)

    Antônio Vander Pereira

    2006-01-01

    Full Text Available O objetivo deste trabalho foi estimar a viabilidade do pólen em acessos de capim-elefante, milheto e híbridos interespecíficos por meio de germinação in vitro e coloração com carmim propiônico, orceína acética e corante de Alexander. Os testes de germinação foram realizados com grãos de pólen frescos e armazenados por 30 dias. Osacessos de capim-elefante e de milheto apresentaram alta viabilidade de pólen. Apenas um deles, quando avaliado com o corante de Alexander, mostrou baixa fertilidade. Para os híbridos, observou-se alta taxa de pólens funcionais com os corantes nucleares. Entretanto,o corante de Alexander confirmou a completa esterilidade desses acessos. Os acessos de capim-elefante e milheto apresentaram baixa porcentagem de pólens viáveis quando induzidos à germinação em meio de cultura. Nos híbridos foi constatada completa esterilidade do grão de pólen, condizente com as anormalidades meióticas relatadas naliteratura. Quanto ao armazenamento, os grãos de pólen de todos os acessos perderam completamente o poder germinativo.The aim of this work was to estimate the pollen viability in elephantgrass, pearl millet and interspecific hybrids accessionsthrough in vitro germination and staining with propionic carmine, acetic orcein and Alexander’s stain. The germination tests were accomplished with fresh pollen grains and stored for 30 days. The elephantgrass and peare millet accessions presented a high pollenviability. Just one of the accessions, when evaluated with Alexander's stain, showed low fertility. For the hybrid, a high rate of functional pollen was observed with the nuclear stain. However, Alexander's stain confirmed the complete sterility of those accessions. Elephantgrass and pearl millet accessions presented a low percentage of viable pollen grain, when induced to germination in culture medium. Complete sterility of the pollen grain was verified in the hybrid, agreeing with the meiotic abnormalities

  7. Viabilidade do grão de pólen de acessos de capim-elefante, milheto - DOI: 10.4025/actascibiolsci.v28i1.1052 Pollen viability in elephantgrass, pearl millet and interspecific hybrids - DOI: 10.4025/actascibiolsci.v28i1.1052

    Directory of Open Access Journals (Sweden)

    Antônio Vander Pereira

    2006-03-01

    Full Text Available O objetivo deste trabalho foi estimar a viabilidade do pólen em acessos de capim-elefante, milheto e híbridos interespecíficos por meio de germinação in vitro e coloração com carmim propiônico, orceína acética e corante de Alexander. Os testes de germinação foram realizados com grãos de pólen frescos e armazenados por 30 dias. Os acessos de capim-elefante e de milheto apresentaram alta viabilidade de pólen. Apenas um deles, quando avaliado com o corante de Alexander, mostrou baixa fertilidade. Para os híbridos, observou-se alta taxa de pólens funcionais com os corantes nucleares. Entretanto, o corante de Alexander confirmou a completa esterilidade desses acessos. Os acessos de capim-elefante e milheto apresentaram baixa porcentagem de pólens viáveis quando induzidos à germinação em meio de cultura. Nos híbridos foi constatada completa esterilidade do grão de pólen, condizente com as anormalidades meióticas relatadas na literatura. Quanto ao armazenamento, os grãos de pólen de todos os acessos perderam completamente o poder germinativoThe aim of this work was to estimate the pollen viability in elephantgrass, pearl millet and interspecific hybrids accessions through in vitro germination and staining with propionic carmine, acetic orcein and Alexander’s stain. The germination tests were accomplished with fresh pollen grains and stored for 30 days. The elephantgrass and peare millet accessions presented a high pollen viability. Just one of the accessions, when evaluated with Alexander's stain, showed low fertility. For the hybrid, a high rate of functional pollen was observed with the nuclear stain. However, Alexander's stain confirmed the complete sterility of those accessions. Elephantgrass and pearl millet accessions presented a low percentage of viable pollen grain, when induced to germination in culture medium. Complete sterility of the pollen grain was verified in the hybrid, agreeing with the meiotic

  8. Micro-hardness evaluation of a micro-hybrid composite resin light cured with halogen light, light-emitting diode and argon ion laser.

    Science.gov (United States)

    Rode, Katia M; de Freitas, Patricia M; Lloret, Patricia R; Powell, Lynn G; Turbino, Miriam L

    2009-01-01

    This in vitro study aimed to determine whether the micro-hardness of a composite resin is modified by the light units or by the thickness of the increment. Composite resin disks were divided into 15 groups (n = 5), according to the factors under study: composite resin thickness (0 mm, 1 mm, 2 mm , 3 mm and 4 mm) and light units. The light activation was performed with halogen light (HL) (40 s, 500 mW/cm(2)), argon ion laser (AL) (30 s, 600 mW/cm(2)) or light-emitting diode (LED) (30 s, 400 mW/cm(2)). Vickers micro-hardness tests were performed after 1 week and were carried out on the top surface (0 mm-control) and at different depths of the samples. Analysis of variance (ANOVA) and Tukey tests (P hardness values than the LED. In groups with 3 mm and 4 mm thickness, the HL also showed higher micro-hardness values than the groups activated by the AL and the LED. Only the HL presented satisfactory polymerization with 3 mm of thickness. With a 4 mm increment no light unit was able to promote satisfactory polymerization.

  9. Clinical application of implantation of blue light-filtering aspheric intraocular lens by micro incision%微切口预装式蓝光滤过非球面人工晶状体临床应用

    Institute of Scientific and Technical Information of China (English)

    刘汝瑜; 宋慧; 汤欣; 魏荫娟

    2015-01-01

    Objective To compare the surgically induced astigmatism (SIA) of 2.0mm coaxial microincision cataract surgery (MICS) with 3.0mm small-incision cataract surgery (SICS) with blue light-filtering aspheric intraocular lens (IOL) implantation.Methods Retrospective case series of 48 cataract eyes undertaken phacoemulsification and IOL implantation from October 2012 to January 2013.MICS:26 eyes with 1-piece blue light-filtering aspheric intraocular lens by micro incision (iSert1,HOYA);SICS:22 eyes with 3-piece blue light-filtering aspheric intraocular lens by small incision (PY60AD,HOYA).Anterior chamber depth after mydriasis,corneal astigmatism,tilt and deviation of IOLs were measured using Scheimpflug system (Pentacam,Oculus) and analyzed with Image-pro plus 6.0 software.Slit lamp anterior segment photography and photoshop7.0 analyzed IOL rotation.Follow up was I week and 1 month.Results A significant SIA difference was found 1 week after surgery (P <0.05),no significant difference was found 1 month after surgery (P >0.05).With dilated pupil,there was a significant difference a month after surgery (P <0.05).No significant difference was found 1 week after surgery (P >0.05).Deviation,tilt and rotation of IOLs between the two groups showed no statistical significance (P >0.05).Conclusions Preloaded blue light-filtering aspheric intraocular lens by micro incision causes smaller SIA,is favor for visual recovery in short-term postoeration.%目的 观察2.0 mm同轴微切口白内障超声乳化(microincision cataract surgery,MICS)吸除术后植入微切口预装式蓝光滤过非球面人工晶状体(IOL)的手术源性散光(surgically induced astigmatism,SIA)及囊袋内稳定性,并与传统3.0 mm小切口白内障超声乳化(small-incision cataract surgery,SICS)手术进行比较.方法 回顾性系列病例研究.回顾性分析天津市眼科医院白内障中心于2012年10月至2013年1月白内障患者48只眼行超声乳化白

  10. 电控可变焦128元×128元自适应液晶微透镜阵列%Electrically driving and controlling adaptive 128 element×128 element liquid crystal micro-lens array with tunable focal length

    Institute of Scientific and Technical Information of China (English)

    李晖; 张新宇; 张天序; 沈绪榜

    2009-01-01

    基于已有的单圆孔电极液晶透镜的结构与设计方法,研制了新型的电控可变焦128元×128元液晶微透镜阵列.该面阵液晶微透镜使用氧化铟锡(ITO)玻璃作为上下基板,上电极通过光刻技术和盐酸腐蚀方法得到128元×128元圆孔阵列图案;下电极为ITO膜.上电极的圆孔阵列排列整齐,每个圆孔的直径为50 μm,圆孔之间的间隔为100 μm,夹在上下基板之间的液晶层的厚度为20 μm.验证了该面阵液晶微透镜的光学特性,结果表明,在0.2~5.0 V(RMS),该面阵液晶微透镜的焦距为50~400 μm,焦点的焦斑尺寸在10 μm左右,点扩展函数值近似于理论数值.该面阵液晶微透镜的工作电压与焦距成反比,可以成清晰的多重像.%A new electrically driving and controlling 128 element × 128 element Liquid Crystal (LC) micro-lens array with tunable focal length is proposed based on the structure and design methods of a single circular hole electrode LC lens.The Indium Tin Oxide (ITO) glasses are used as the top and bottom substrates of the LC micro-lens array.The top electrode patterns containing 128 element×128 element are obtained by a lithography and a hydrochloric acid etching,in which every element is a single circular hole of 50 μm diameter and the distance between the two circular holes is 100 μm.The bottom electrode is just the ITO film.Furthermore,the thickness of LC layer between the top and the bottom electrodes is about 20 μm and the focal length of the LC micro-lens array can be electrically tuned from 50 μm to 400 μm under the operating voltage from 0.2 V (RMS) to 5.0 V(RMS).The result of the test indicates that the point spread function of the LC micro-lens array is close to the theory value,and the relationship of operating voltage and focal length is in an inverse proportion.These results show that the imaging characteristic of the LC micro-lens array can be comparable to those of the conventional optical micro-lens

  11. Identification of strain fields in pure Al and hybrid Ni/Al metal foams using X-ray micro-tomography under loading

    Science.gov (United States)

    Fíla, T.; Jiroušek, O.; Jung, A.; Kumpová, I.

    2016-11-01

    Hybrid foams are materials formed by a core from a standard open cell metal foam that is during the process of electrodeposition coated by a thin layer of different nanocrystalline metals. The material properties of the base metal foam are in this way modified resulting in higher plateau stress and, more importantly, by introduction of strain-rate dependence to its deformation response. In this paper, we used time-lapse X-ray micro-tomography for the mechanical characterization of Ni/Al hybrid foams (aluminium open cell foams with nickel coating layer). To fully understand the effects of the coating layer on the material's effective properties, we compared the compressive response of the base uncoated foam to the response of the material with coating thickness of 50 and 75 μm. Digital volume correlation (DVC) was applied to obtain volumetric strain fields of the deforming micro-structure up to the densification region of the deforming cellular structure. The analysis was performed as a compressive mechanical test with simultaneous observation using X-ray radiography and tomography. A custom design experimental device was used for compression of the foam specimens in several deformation states directly in the X-ray setup. Planar X-ray images were taken during the loading phases and a X-ray tomography was performed at the end of each loading phase (up to engineering strain 22%). The samples were irradiated using micro-focus reflection type X-ray tube and images were taken using a large area flat panel detector. Tomography reconstructions were used for an identification of a strain distribution in the foam using digital volumetric correlation. A comparison of the deformation response of the coated and the uncoated foam in uniaxial quasi-static compression is summarized in the paper.

  12. A single-pixel wireless contact lens display

    Science.gov (United States)

    Lingley, A. R.; Ali, M.; Liao, Y.; Mirjalili, R.; Klonner, M.; Sopanen, M.; Suihkonen, S.; Shen, T.; Otis, B. P.; Lipsanen, H.; Parviz, B. A.

    2011-12-01

    We present the design, construction and in vivo rabbit testing of a wirelessly powered contact lens display. The display consists of an antenna, a 500 × 500 µm2 silicon power harvesting and radio integrated circuit, metal interconnects, insulation layers and a 750 × 750 µm2 transparent sapphire chip containing a custom-designed micro-light emitting diode with peak emission at 475 nm, all integrated onto a contact lens. The display can be powered wirelessly from ~1 m in free space and ~2 cm in vivo on a rabbit. The display was tested on live, anesthetized rabbits with no observed adverse effect. In order to extend display capabilities, design and fabrication of micro-Fresnel lenses on a contact lens are presented to move toward a multipixel display that can be worn in the form of a contact lens. Contact lenses with integrated micro-Fresnel lenses were also tested on live rabbits and showed no adverse effect.

  13. Rapid cooled lens cell

    Science.gov (United States)

    Stubbs, David M.; Hsu, Ike C.

    1991-12-01

    This paper describes the optomechanical design, thermal analysis, fabrication, and test evaluation processes followed in developing a rapid cooled, infrared lens cell. Thermal analysis was the key engineering discipline exercised in the design phase. The effect of thermal stress on the lens, induced by rapid cooling of the lens cell, was investigated. Features of this lens cell that minimized the thermal stress will be discussed in a dedicated section. The results of thermal analysis on the selected lens cell design and the selection of the flow channel design in the heat exchanger will be discussed. Throughout the paper engineering drawings, illustrations, analytical results, and photographs of actual hardware are presented.

  14. Self-assembly micro optical filter

    Science.gov (United States)

    Zhang, Ping (Cerina); Le, Kevin; Malalur-Nagaraja-Rao, Smitha; Hsu, Lun-Chen; Chiao, J.-C.

    2006-01-01

    Optical communication and sensor industry face critical challenges in manufacturing for system integration. Due to the assembly complexity and integration platform variety, micro optical components require costly alignment and assembly procedures, in which many required manual efforts. Consequently, self-assembly device architectures have become a great interest and could provide major advantages over the conventional optical devices. In this paper, we discussed a self-assembly integration platform for micro optical components. To demonstrate the adaptability and flexibility of the proposed optical device architectures, we chose a commercially available MEMS fabrication foundry service - MUMPs (Multi-User MEMS Process). In this work, polysilicon layers of MUMPS are used as the 3-D structural material for construction of micro component framework and actuators. However, because the polysilicon has high absorption in the visible and near infrared wavelength ranges, it is not suitable for optical interaction. To demonstrate the required optical performance, hybrid integration of materials was proposed and implemented. Organic compound materials were applied on the silicon-based framework to form the required optical interfaces. Organic compounds provide good optical transparency, flexibility to form filters or lens and inexpensive manufacturing procedures. In this paper, we have demonstrated a micro optical filter integrated with self-assembly structures. We will discuss the self-assembly mechanism, optical filter designs, fabrication issues and results.

  15. Revealing details: whole mount microRNA in situ hybridization protocol for zebrafish embryos and adult tissues

    NARCIS (Netherlands)

    Lagendijk, A.K.; Moulton, J.D.; Bakkers, J.

    2012-01-01

    Non-coding microRNA (miRNA) molecules bind their target mRNAs and thereby modulate the amount of protein produced. To understand the significance of a potential miRNA-mRNA interaction, temporal and spatial information on miRNA and mRNA expression is essential. Here, we provide a detailed protocol fo

  16. Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleicacid probes and tyramide signal amplification

    DEFF Research Database (Denmark)

    Silahtaroglu, Asli N.; Nolting, Dorrit; Andersen, Lars Dyrskjøt;

    2007-01-01

    The ability to determine spatial and temporal microRNA (miRNA) accumulation at the tissue, cell and subcellular levels is essential for understanding the biological roles of miRNAs and miRNA-associated gene regulatory networks. This protocol describes a method for fast and effective detection of mi......RNAs in frozen tissue sections using fluorescence in situ hybridization (FISH). The method combines the unique miRNA recognition properties of locked nucleic acid (LNA)-modified oligonucleotide probes with FISH using the tyramide signal amplification (TSA) technology. Although both approaches have previously...... protocol can be completed within approximately 6 h and allows miRNA detection in a wide variety of animal tissue cryosections as well as in human tumor biopsies at high cellular resolution....

  17. Structures and properties of layered bioceramic coatings on pure titanium using a hybrid technique of sandblasting and micro-arc oxidation

    Science.gov (United States)

    Wang, Hong-Yuan; Zhu, Rui-Fu; Lu, Yu-Peng; Xiao, Gui-Yong; Ma, Xiao-Ni; Li, Ying

    2013-10-01

    Sandblasting is the most ordinary approach not only to leave the treated regions in compressive residual stress states but also to alter the surface topography of an implant, and micro-arc oxidation (MAO) provides a novelly effective way to produce porous, adhesive and bioactive implant coatings. In this study, ceramic coatings containing Ca and P elements were deposited on the sandblasted pure titanium substrates through the MAO process, and the bioactive performance of the coatings was improved. In addition, the variation of morphology and microstructure, phase and element composition of the coatings according to treating time and related properties were characterized and analyzed, respectively. It was indicated that the hybrid-treated coatings exhibited better properties than that by MAO method, especially in hydroxyapatite (HA) inducing ability, as evidenced by characterization test and HA formation after simulated body fluid (SBF) immersion for days. The enhancement of modified surface was attributed to the combination of the physical and electrochemical treatments.

  18. High-contrast X-ray micro-tomography of low attenuation samples using large area hybrid semiconductor pixel detector array of 10 × 5 Timepix chips

    Science.gov (United States)

    Karch, J.; Krejci, F.; Bartl, B.; Dudak, J.; Kuba, J.; Kvacek, J.; Zemlicka, J.

    2016-01-01

    State-of-the-art hybrid pixel semiconductor detectors provide excellent imaging properties such as unlimited dynamic range, high spatial resolution, high frame rate and energy sensitivity. Nevertheless, a limitation in the use of these devices for imaging has been the small sensitive area of a few square centimetres. In the field of microtomography we make use of a large area pixel detector assembled from 50 Timepix edgeless chips providing fully sensitive area of 14.3 × 7.15 cm2. We have successfully demonstrated that the enlargement of the sensitive area enables high-quality tomographic measurements of whole objects with high geometrical magnification without any significant degradation in resulting reconstructions related to the chip tilling and edgeless sensor technology properties. The technique of micro-tomography with the newly developed large area detector is applied for samples formed by low attenuation, low contrast materials such a seed from Phacelia tanacetifolia, a charcoalified wood sample and a beeswax seal sample.

  19. Elliptical concave microlens arrays built in the photosensitive TiO2/ormosils hybrid films

    Science.gov (United States)

    Zhang, Xuehua; Que, Wenxiu; Javed, Hafiz M. Asif; Wei, Wei

    2014-11-01

    Photosensitive TiO2/organically modified silane hybrid thin films were prepared by a low-temperature sol-gel spin-coating technique. Optical and structural properties of the hybrid films with different titanium contents were characterized by prism coupling technique, UV-visible spectroscopy, Fourier transform infrared spectroscopy, and thermal gravimetric analysis. Advantages for fabrication of elliptical concave micro-lens arrays (MLAs) based on the as-prepared hybrid films were demonstrated by combining polydimethylsiloxane soft mold with a UV-cured imprint technique. Results indicate that the as-prepared hybrid films have great applicability for the fabrication of photonic components, and the fabrication technique provides a simple and cost-effective way for the fabrication of the sol-gel elliptical concave MLAs.

  20. Hybrid Macro-Porous Titanium Ornamented by Degradable 3D Gel/nHA Micro-Scaffolds for Bone Tissue Regeneration

    Science.gov (United States)

    Yin, Bo; Ma, Pei; Chen, Jun; Wang, Hai; Wu, Gui; Li, Bo; Li, Qiang; Huang, Zhifeng; Qiu, Guixing; Wu, Zhihong

    2016-01-01

    Porous titanium is a kind of promising material for bone substitution, while its bio-inert property results in demand of modifications to improve the osteointegration capacity. In this study, gelatin (Gel) and nano-hydroxyapatite (nHA) were used to construct 3D micro-scaffolds in the pores of porous titanium in the ratios of Gel:nHA = 1:0, Gel:nHA = 1:1, and Gel:nHA = 1:3, respectively. Cell attachment and proliferation, and gene and protein expression levels of osteogenic markers were evaluated in MC3T3-E1 cells, followed by bone regeneration assessment in a rabbit radius defect model. All hybrid scaffolds with different composition ratio were found to have significant promotional effects in cell adhesion, proliferation and differentiation, in which the group with Gel:nHA = 1:1 showed the best performance in vitro, as well as the most bone regeneration volume in vivo. This 3D micro-scaffolds modification may be an innovative method for porous titanium ornamentation and shows potential application values in clinic. PMID:27092492

  1. Hybrid Macro-Porous Titanium Ornamented by Degradable 3D Gel/nHA Micro-Scaffolds for Bone Tissue Regeneration

    Directory of Open Access Journals (Sweden)

    Bo Yin

    2016-04-01

    Full Text Available Porous titanium is a kind of promising material for bone substitution, while its bio-inert property results in demand of modifications to improve the osteointegration capacity. In this study, gelatin (Gel and nano-hydroxyapatite (nHA were used to construct 3D micro-scaffolds in the pores of porous titanium in the ratios of Gel:nHA = 1:0, Gel:nHA = 1:1, and Gel:nHA = 1:3, respectively. Cell attachment and proliferation, and gene and protein expression levels of osteogenic markers were evaluated in MC3T3-E1 cells, followed by bone regeneration assessment in a rabbit radius defect model. All hybrid scaffolds with different composition ratio were found to have significant promotional effects in cell adhesion, proliferation and differentiation, in which the group with Gel:nHA = 1:1 showed the best performance in vitro, as well as the most bone regeneration volume in vivo. This 3D micro-scaffolds modification may be an innovative method for porous titanium ornamentation and shows potential application values in clinic.

  2. Hybrid Macro-Porous Titanium Ornamented by Degradable 3D Gel/nHA Micro-Scaffolds for Bone Tissue Regeneration.

    Science.gov (United States)

    Yin, Bo; Ma, Pei; Chen, Jun; Wang, Hai; Wu, Gui; Li, Bo; Li, Qiang; Huang, Zhifeng; Qiu, Guixing; Wu, Zhihong

    2016-04-15

    Porous titanium is a kind of promising material for bone substitution, while its bio-inert property results in demand of modifications to improve the osteointegration capacity. In this study, gelatin (Gel) and nano-hydroxyapatite (nHA) were used to construct 3D micro-scaffolds in the pores of porous titanium in the ratios of Gel:nHA = 1:0, Gel:nHA = 1:1, and Gel:nHA = 1:3, respectively. Cell attachment and proliferation, and gene and protein expression levels of osteogenic markers were evaluated in MC3T3-E1 cells, followed by bone regeneration assessment in a rabbit radius defect model. All hybrid scaffolds with different composition ratio were found to have significant promotional effects in cell adhesion, proliferation and differentiation, in which the group with Gel:nHA = 1:1 showed the best performance in vitro, as well as the most bone regeneration volume in vivo. This 3D micro-scaffolds modification may be an innovative method for porous titanium ornamentation and shows potential application values in clinic.

  3. Effect of micro-nano-hybrid structured hydroxyapatite bioceramics on osteogenic and cementogenic differentiation of human periodontal ligament stem cell via Wnt signaling pathway.

    Science.gov (United States)

    Mao, Lixia; Liu, Jiaqiang; Zhao, Jinglei; Chang, Jiang; Xia, Lunguo; Jiang, Lingyong; Wang, Xiuhui; Lin, Kaili; Fang, Bing

    2015-01-01

    The surface structure of bioceramic scaffolds is crucial for its bioactivity and osteoinductive ability, and in recent years, human periodontal ligament stem cells have been certified to possess high osteogenic and cementogenic differential ability. In the present study, hydroxyapatite (HA) bioceramics with micro-nano-hybrid surface (mnHA [the hybrid of nanorods and microrods]) were fabricated via hydrothermal reaction of the α-tricalcium phosphate granules as precursors in aqueous solution, and the effects of mnHA on the attachment, proliferation, osteogenic and cementogenic differentiations of human periodontal ligament stem cells as well as the related mechanisms were systematically investigated. The results showed that mnHA bioceramics could promote cell adhesion, proliferation, alkaline phosphatase (ALP) activity, and expression of osteogenic/cementogenic-related markers including runt-related transcription factor 2 (Runx2), ALP, osteocalcin (OCN), cementum attachment protein (CAP), and cementum protein (CEMP) as compared to the HA bioceramics with flat and dense surface. Moreover, mnHA bioceramics stimulated gene expression of low-density lipoprotein receptor-related protein 5 (LRP5) and β-catenin, which are the key genes of canonical Wnt signaling. Moreover, the stimulatory effect on ALP activity and osteogenic and cementogenic gene expression, including that of ALP, OCN, CAP, CEMP, and Runx2 of mnHA bioceramics could be repressed by canonical Wnt signaling inhibitor dickkopf1 (Dkk1). The results suggested that the HA bioceramics with mnHA could act as promising grafts for periodontal tissue regeneration.

  4. Pentynyl Ether of β-Cyclodextrin Polymer and Silica Micro-Particles: A New Hybrid Material for Adsorption of Phenanthrene from Water

    Directory of Open Access Journals (Sweden)

    Jae Min Choi

    2017-01-01

    Full Text Available A new hybrid material for the removal of polycyclic aromatic hydrocarbons (PAH from water was prepared by the polymerization of pentynyl beta-cyclodextrin (PyβCD and silica micro-particles (SMP. Phenanthrene, being one of the important members of the PAH family and a potential risk for environmental pollution, was selected for this study. Results show that phenanthrene removal efficiency of the SMP was improved significantly after hybridization with PyβCD-polymer. Approximately 50% of the phenanthrene was removed in the first 60 min and more than 95% was removed in less than 7 h when 25 mL of the 2 ppm aqueous phenanthrene solution was incubated with the 100 mg of SMP-PyβCD-polymer material. Infrared spectroscopy and thermal gravimetric analysis show that the enhanced efficiency of the SMP-PyβCD-polymer compared to the unmodified SMP was due to the formation of the inclusion complexation of phenanthrene with the PyβCD. These results indicate that SMP-PyβCD polymers have a potential to be applied as molecular filters in water purification systems and also for waste water treatment.

  5. Reducing the thermal stress in a heterogeneous material stack for large-area hybrid optical silicon-lithium niobate waveguide micro-chips

    Science.gov (United States)

    Weigel, P. O.; Mookherjea, S.

    2017-04-01

    The bonding of silicon-on-insulator (SOI) to lithium niobate-on-insulator (LNOI) is becoming important for a new category of linear and nonlinear micro-photonic optical devices. In studying the bonding of SOI to LNOI through benzocyclobutene (BCB), a popular interlayer bonding dielectric used in hybrid silicon photonic devices, we use thermal stress calculations to suggest that BCB thickness does not affect thermal stress in this type of structure, and instead, thermal stress can be mitigated satisfactorily by matching the handles of the SOI and LNOI. We bond LNOI with a silicon handle to a silicon chip, remove the handle on the LNOI side, and thermally cycle the bonded stack repeatedly from room temperature up to 300°C and back down without incurring thermal stress cracks, which do appear when using LNOI with a lithium niobate handle, regardless of the BCB thickness. We show that this process can be used to create many hybrid silicon-lithium niobate waveguiding structures on a single patterned SOI chip bonded to a large-area (16 mm × 4.2 mm) lithium niobate film.

  6. Iatrogenic Lens Injuries

    Directory of Open Access Journals (Sweden)

    Ümit Kamış

    2012-12-01

    Full Text Available During intraocular surgery, undesired damages of various etiology may occur in adjacent tissues. One of these tissues is the crystalline lens, which may be traumatized both in anterior segment and posterior segment surgeries, and when damaged, it usually causes marked decrease in visual acuity. The leading causes of iatrogenic lens injuries are intravitreal injection, laser iridotomy, phakic intraocular lens implantation, anterior chamber paracentesis, and vitreoretinal surgery. When crystalline lens damage occurs, its negative effect on visual function may be eliminated by performing cataract surgery intraoperatively or in elective conditions. (Turk J Ophthalmol 2012; 42: Supplement 27-30

  7. Graphene oxide-gold nanoparticles hybrids-based surface plasmon resonance for sensitive detection of microRNA.

    Science.gov (United States)

    Wang, Qing; Li, Qing; Yang, Xiaohai; Wang, Kemin; Du, Shasha; Zhang, Hua; Nie, Yajie

    2016-03-15

    In this study, a simple and sensitive surface plasmon resonance (SPR) biosensor for miRNA detection was developed using graphene oxide-gold nanoparticles (GO-AuNPs) hybrids as signal amplification element. Taking advantage of the GO-AuNPs hybrids and their enhanced performance in SPR biosensors, the detection of miRNA was carried out in only two steps. Firstly, the thiolated capture DNA probe with a short complete complementary sequence was immobilized on the Au film surface to recognize the part sequence of target miRNA. Subsequently, the assistant DNA-linked GO-AuNPs hybrids were employed to bind the other section of the target. It was found that the developed SPR biosensor was able to achieve a detection limit as low as 1 fM. Moreover, the method showed excellent ability to discriminate differences among miRNA-200 family members. Notably, human miRNA from cancer cells could also be detected, and the results were in excellent agreement with the ones obtained using qRT-PCR. On the basis of these findings, we believe that this method has great potential for quantitative detection of miRNA in biomedical research and early clinical diagnostics.

  8. Concept design and simulation of a concentration lens with uniform square irradiance

    Science.gov (United States)

    Li, Dianhong; Xuan, Yimin

    2017-10-01

    A planar concentration lens comprised of square and rectangular lenses for solar concentration application is presented. The design of the concentration lens was based on the concept of Fresnel lens and the layout of the square light spot was proposed to match the receiving area. The uniformity of the light spot was determined by the structure of the concentration lens, which has different structures for different design wavelengths. The uniformity of the light spot and concentration ratio of the concentration lens were simulated. The numerical results indicate that the concentration ratio and uniformity of the light spot decrease with the increment of the wavelength. In order to improve the performance of the concentration lens, a novel hybrid wavelength structures was designed. The analysis results reveal that both the spot uniformity and concentration ratio of such a novel concentration lens were insensitive to the wavelengths variation. In addition, the angular tolerance of the concentration lens was discussed for different incident angles.

  9. Dielectric Optical-Controlled Magnifying Lens by Nonlinear Negative Refraction

    CERN Document Server

    Cao, Jianjun; Zheng, Yuanlin; Chen, Xianfeng; Liang, Xiaogan; Wan, Wenjie

    2014-01-01

    A simple optical lens plays an important role for exploring the microscopic world in science and technology by refracting light with tailored spatially varying refractive index. Recent advancements in nanotechnology enable novel lenses, such as, superlens, hyperlens, Luneburg lens, with sub-wavelength resolution capabilities by specially designing materials' refractive indices with meta-materials and transformation optics. However, these artificially nano/micro engineered lenses usually suffer high losses from metals and are highly demanding in fabrication. Here we experimentally demonstrate for the first time a nonlinear dielectric magnifying lens using negative refraction by degenerate four-wave mixing in a plano-concave glass slide, obtaining magnified images. Moreover, we transform a nonlinear flat lens into a magnifying lens by introducing transformation optics into nonlinear regime, achieving an all-optical controllable lensing effect through nonlinear wave mixing, which may have many potential applicat...

  10. Modelling of a Biomass Gasification Plant Feeding a Hybrid Solid Oxide Fuel Cell and Micro Gas Turbine System

    DEFF Research Database (Denmark)

    Bang-Møller, Christian; Rokni, Masoud

    2009-01-01

    A system level modelling study on two combined heat and power (CHP) systems both based on biomass gasification. One system converts the product gas in a solid oxide fuel cell (SOFC) and the other in a combined SOFC and micro gas turbine (MGT) arrangement. An electrochemical model of the SOFC has...... syngas from the SOFC to produce more power as well as pressurizing the SOFC bettering the electrical efficiency compared to operation with the SOFC alone - from η_el=36.4% to η_el=50.3%....

  11. The comparison of the effects of different whitening toothpastes on the micro hardness of a nano hybrid composite resin

    OpenAIRE

    Mohan Thomas Nainan; Ashok Kalappurakkal Balan; Roshni Sharma; Sabeena Susan Thomas; Santhosh B Deveerappa

    2014-01-01

    Aim: The aim of this study was to compare the micro hardness of a nanohybrid composite resin after brushing with two herbal and one non-herbal whitening toothpastes. Materials and Methods: We divided Eighty disk-shaped specimens of a nanohybrid composite (Tetric N Ceram, Ivoclar Vivadent, Asia) into 4 groups of 20 specimens each: Groups A, B, C, and D. Group A was control, Group B was brushed with Colgate total advanced whitening (Colgate-Palmolive (India) Limited), Group C with Salt and ...

  12. Superlensing Microscope Objective Lens

    CERN Document Server

    Yan, Bing; Parker, Alan; Lai, Yukun; Thomas, John; Yue, Liyang; Monks, James

    2016-01-01

    Conventional microscope objective lenses are diffraction limited, which means that they cannot resolve features smaller than half the illumination wavelength. Under white light illumination, such resolution limit is about 250-300 nm for an ordinary microscope. In this paper, we demonstrate a new superlensing objective lens which has a resolution of about 100 nm, offering at least two times resolution improvement over conventional objectives in resolution. This is achieved by integrating a conventional microscope objective lens with a superlensing microsphere lens using a 3D printed lens adaptor. The new objective lens was used for label-free super-resolution imaging of 100 nm-sized engineering and biological samples, including a Blu-ray disc sample, semiconductor chip and adenoviruses. Our work creates a solid base for developing a commercially-viable superlens prototype, which has potential to transform the field of optical microscopy and imaging.

  13. High numerical aperture all-dielectric metasurface micro-lenses

    NARCIS (Netherlands)

    Silvestri, F.; Gerini, G.; Pisano, E.; Galdi, V.

    2015-01-01

    In this paper, the design principles and the sensitivity analysis needed for the realization of a high numerical aperture metasurface micro-lens are presented. The metasurface micro-lens is realized defining a surface with spatially-variant dielectric resonators embedded in a dielectric bulk. The de

  14. Modelling of a Biomass Gasification Plant Feeding a Hybrid Solid Oxide Fuel Cell and Micro Gas Turbine System

    DEFF Research Database (Denmark)

    Bang-Møller, Christian; Rokni, Masoud

    2009-01-01

    A system level modelling study on two combined heat and power (CHP) systems both based on biomass gasification. One system converts the product gas in a solid oxide fuel cell (SOFC) and the other in a combined SOFC and micro gas turbine (MGT) arrangement. An electrochemical model of the SOFC has...... been developed and calibrated against published data from Topsoe Fuel Cells A/S (TOFC) and Risø National Laboratory. The modelled gasifier is based on an up scaled version of the demonstrated low tar gasifier, Viking, situated at the Technical University of Denmark. The MGT utilizes the unconverted...... syngas from the SOFC to produce more power as well as pressurizing the SOFC bettering the electrical efficiency compared to operation with the SOFC alone - from η_el=36.4% to η_el=50.3%....

  15. Cell-specific detection of microRNA expression during cardiomyogenesis by combined in situ hybridization and immunohistochemistry

    DEFF Research Database (Denmark)

    Schneider, Mikael; Andersen, Ditte Caroline; Silahtaroglu, Asli

    2011-01-01

    . However, although several miRNAs have been identified as differentially regulated during cardiac development and disease, their distinct cell-specific localization remains largely undetermined, likely owing to a lack of adequate methods. We therefore report the development of a markedly improved approach...... combining fluorescence-based miRNA-in situ hybridization (miRNA-ISH) with immunohistochemistry (IHC). We have applied this protocol to differentiating embryoid bodies (EBs) as well as embryonic and adult mouse hearts, to detect miRNAs that were upregulated during EB cardiomyogenesis, as determined by array...... present highlight the importance of determining exact cell-specific localization of miRNAs by sequential miRNA-ISH and IHC in studies aiming at understanding the role of miRNAs and their targets. This approach will hopefully aid in identifying relevant miRNA targets of both the heart and other organs....

  16. Characterization of continuous and pulsed emission modes of a hybrid micro focus x-ray source for medical imaging applications

    Science.gov (United States)

    Ghani, Muhammad U.; Wong, Molly D.; Ren, Liqiang; Wu, Di; Zheng, Bin; Rong, John. X.; Wu, Xizeng; Liu, Hong

    2017-05-01

    The aim of this study was to quantitatively characterize a micro focus x-ray tube that can operate in both continuous and pulsed emission modes. The micro focus x-ray source (Model L9181-06, Hamamatsu Photonics, Japan) has a varying focal spot size ranging from 16 μm to 50 μm as the source output power changes from 10 to 39 W. We measured the source output, beam quality, focal spot sizes, kV accuracy, spectra shapes and spatial resolution. Source output was measured using an ionization chamber for various tube voltages (kVs) with varying current (μA) and distances. The beam quality was measured in terms of half value layer (HVL), kV accuracy was measured with a non-invasive kV meter, and the spectra was measured using a compact integrated spectrometer system. The focal spot sizes were measured using a slit method with a CCD detector with a pixel pitch of 22 μm. The spatial resolution was quantitatively measured using the slit method with a CMOS flat panel detector with a 50 μm pixel pitch, and compared to the qualitative results obtained by imaging a contrast bar pattern. The focal spot sizes in the vertical direction were smaller than that of the horizontal direction, the impact of which was visible when comparing the spatial resolution values. Our analyses revealed that both emission modes yield comparable imaging performances in terms of beam quality, spectra shape and spatial resolution effects. There were no significantly large differences, thus providing the motivation for future studies to design and develop stable and robust cone beam imaging systems for various diagnostic applications.

  17. 飞秒激光微切口角膜基质透镜取出术疗效分析%Effect analysis of femtosecond laser micro incision corneal stroma lens removal

    Institute of Scientific and Technical Information of China (English)

    王跃静; 徐新荣; 张传伟; 吴静; 黄海燕

    2015-01-01

    目的::比较飞秒激光微切口角膜基质透镜摘除术( femtosecond laser micro - incision corneal stroma lens removal,SMILE)与准分子激光原位角膜磨镶术( excimer laser in situ wear for cornea, LASIK)治疗近视的术后疗效,探讨SMILE的安全性、可操作性和预测性。方法:前瞻性临床对照研究。随机选取我院同时期行SMILE患者100例200眼和行LASIK患者100例200眼。比较两组1d;1wk;1,3,6mo;1a术后裸眼视力、屈光度、矫正视力、裂隙灯角膜的检查、眼压及前节OCT、角膜地形图( ObscanⅡ)。采用独立样本t检验进行数据分析。结果:(1)术后裂隙灯检查:术后1d,SMILE组少部分术眼有轻度角膜层间混浊或水肿;术后1wk,SMILE组角膜层间的混浊水肿均消失,角膜恢复清亮透明。(2)术后视力恢复:术后1d,LASIK组视力恢复优于SMILE组,差异有显著统计学意义(P0.05)。(3) ObscanⅡ检查:术后随访中,SMILE组角膜前表面图形更加规则和居中,无偏心和不规则图形,优于 LASIK 组。(4)眼前节 OCT 的检查:SMILE组术后角膜瓣更加均匀和精准;而 LASIK 组角膜瓣中间薄,中周部略厚。(5)术后视觉质量评估采用主观问卷调查。两组4分和1分差异有统计学意义(P0. 05 ). 3 ) Obscan ll examination: graphics in the SMlLE group was more regular and placed in the center, no eccentric and irregular graphics, better than that in the LASlK group. 4) Anterior segment OCT examination:postoperative corneal flap in the SMlLE group was more uniform and accurate, but it was thin in the center and slightly thick the peripheral part in the LASlK groups. 5 ) Postoperative visual quality assessment used subjective questionnaire survey. The two groups had statistically significant difference on 4 points and 1 points (P<0. 05). Complains in the LASlK groups were more that that in the SMlLE group. While, no complain of the SMlLE group was higher than that of the LASlK group

  18. Achromatic Fresnel Lens with Improved Efficiency for PV Systems

    Directory of Open Access Journals (Sweden)

    Mario González Montes

    2014-01-01

    Full Text Available This work is aimed to design and evaluate different achromatic Fresnel lens solutions capable of operating as concentrators aimed at photovoltaic cells systems. Throughout this study, the theoretical parametric design of the achromatic lens will be shown together with a series of simulations to verify the performance of each lens topology. The results will be compared with a standard Fresnel lens to ascertain the validity and effectiveness of the obtained design. Finally, a novel kind of hybrid lens is proposed, which combines the advantages of each type of lens (standard and Fresnel according to the optimal operating region of each design. Efficiency and concentration ratios of each particular lens are shown, regarding lens dimension, light’s incidence angle, or wavelength. Through this innovative achromatic design concentration ratios above 1000 suns, which hardly reach standard Fresnel lenses. Furthermore chromatic dispersion is minimized and the efficiency rate is over 85% of efficiency for a wide spectral range (from 350 nm to 1100 nm.

  19. Unitary lens semiconductor device

    Science.gov (United States)

    Lear, Kevin L.

    1997-01-01

    A unitary lens semiconductor device and method. The unitary lens semiconductor device is provided with at least one semiconductor layer having a composition varying in the growth direction for unitarily forming one or more lenses in the semiconductor layer. Unitary lens semiconductor devices may be formed as light-processing devices such as microlenses, and as light-active devices such as light-emitting diodes, photodetectors, resonant-cavity light-emitting diodes, vertical-cavity surface-emitting lasers, and resonant cavity photodetectors.

  20. Intraocular lens fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Salazar, M.A.; Foreman, L.R.

    1997-07-08

    This invention describes a method for fabricating an intraocular lens made from clear Teflon{trademark}, Mylar{trademark}, or other thermoplastic material having a thickness of about 0.025 millimeters. These plastic materials are thermoformable and biocompatable with the human eye. The two shaped lenses are bonded together with a variety of procedures which may include thermosetting and solvent based adhesives, laser and impulse welding, and ultrasonic bonding. The fill tube, which is used to inject a refractive filling material is formed with the lens so as not to damage the lens shape. A hypodermic tube may be included inside the fill tube. 13 figs.

  1. Intraocular lens fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Salazar, Mike A. (Albuquerque, NM); Foreman, Larry R. (Los Alamos, NM)

    1997-01-01

    This invention describes a method for fabricating an intraocular lens made rom clear Teflon.TM., Mylar.TM., or other thermoplastic material having a thickness of about 0.025 millimeters. These plastic materials are thermoformable and biocompatable with the human eye. The two shaped lenses are bonded together with a variety of procedures which may include thermosetting and solvent based adhesives, laser and impulse welding, and ultrasonic bonding. The fill tube, which is used to inject a refractive filling material is formed with the lens so as not to damage the lens shape. A hypodermic tube may be included inside the fill tube.

  2. Dual-energy X-ray micro-CT imaging of hybrid Ni/Al open-cell foam

    Science.gov (United States)

    Fíla, T.; Kumpová, I.; Koudelka, P.; Zlámal, P.; Vavřík, D.; Jiroušek, O.; Jung, A.

    2016-01-01

    In this paper, we employ dual-energy X-ray microfocus tomography (DECT) measurement to develop high-resolution finite element (FE) models that can be used for the numerical assessment of the deformation behaviour of hybrid Ni/Al foam subjected to both quasi-static and dynamic compressive loading. Cubic samples of hybrid Ni/Al open-cell foam with an edge length of [15]mm were investigated by the DECT measurement. The material was prepared using AlSi7Mg0.3 aluminium foam with a mean pore size of [0.85]mm, coated with nanocrystalline nickel (crystallite size of approx. [50]nm) to form a surface layer with a theoretical thickness of [0.075]mm. CT imaging was carried out using state-of-the-art DSCT/DECT X-ray scanner developed at Centre of Excellence Telč. The device consists of a modular orthogonal assembly of two tube-detector imaging pairs, with an independent geometry setting and shared rotational stage mounted on a complex 16-axis CNC positioning system to enable unprecedented measurement variability for highly-detailed tomographical measurements. A sample of the metal foam was simultaneously irradiated using an XWT-240-SE reflection type X-ray tube and an XWT-160-TCHR transmission type X-ray tube. An enhanced dual-source sampling strategy was used for data acquisition. X-ray images were taken using XRD1622 large area GOS scintillator flat panel detectors with an active area of [410 × 410]mm and resolution [2048 × 2048]pixels. Tomographic scanning was performed in 1,200 projections with a 0.3 degree angular step to improve the accuracy of the generated models due to the very complex microstructure and high attenuation of the investigated material. Reconstructed data was processed using a dual-energy algorithm, and was used for the development of a 3D model and voxel model of the foam. The selected parameters of the models were compared with nominal parameters of the actual foam and showed good correlation.

  3. Micro arc oxidized HAp-TiO 2 nanostructured hybrid layers-part I: Effect of voltage and growth time

    Science.gov (United States)

    Abbasi, S.; Bayati, M. R.; Golestani-Fard, F.; Rezaei, H. R.; Zargar, H. R.; Samanipour, F.; Shoaei-Rad, V.

    2011-05-01

    Micro arc oxidation was employed to grow hydroxyapatite-TiO 2 nanostructured porous composite layers. The layers were synthesized on the titanium substrates in the electrolytes consisting of calcium acetate and sodium β-glycerophosphate salts under different applied voltages for various times. SEM and AFM investigations revealed a porous structure and rough surface where the pores size and the surface roughness were respectively determined as 70-650 nm and 9.8-12.7 nm depending on the voltage and time. Chemical composition and phase structure of the layers were evaluated using EDX, XPS, and XRD methods. The layers consisted of the hydroxyapatite, anatase, α-TCP, and calcium titanatephases with a varying fraction depending on the growth conditions. The hydroxyapatite crystalline size was also determined as ˜42 nm. The sample fabricated under the voltage of 350 V for 3 min exhibited the most appropriate Ca/P ratio (˜1.60) as well as the highest amount of the hydroxyapatite phase. This sample had a fine surface morphology and a high pores density.

  4. Label-Free MicroRNA Detection Based on Fluorescence Quenching of Gold Nanoparticles with a Competitive Hybridization.

    Science.gov (United States)

    Wang, Wei; Kong, Tao; Zhang, Dong; Zhang, Jinan; Cheng, Guosheng

    2015-11-01

    MicroRNAs (miRNAs), critical biomarkers of acute and chronic diseases, play key regulatory roles in many biological processes. As a result, there is great demand for robust assay platforms to enable an accurate and efficient detection of low-level miRNAs in complex biological samples. In this work, a label-free and Au nanoparticles (NPs) quenching-based competition assay system was developed. In the designed system, Au NPs with diameter sizes of 10 and 20 nm displayed fluorescence quenching efficiencies of 84% and 82% for Cy3 dye on slide surface, whereas the quenching efficiency of commercial BHQ2 quencher was roughly 50%. Assay conditions were optimized for miRNA-205 detection. A limit of detection of 3.8 pM and a detection range covering from 3.8 pM to 10 nM were achieved. Furthermore, the proposed system was capable of specifically discriminating miRNAs with slight variations in their nucleotide sequence and was also qualified for assessing miRNA levels in human serum. Our strategy has the potential to provide new perspectives in profiling the pattern of miRNA expression and biomedical utilizations.

  5. A Robotic System with a Hybrid Motion Cueing Controller for Inertia Tensor Approximation in Micro-Manipulations

    Directory of Open Access Journals (Sweden)

    Umar Asif

    2011-09-01

    Full Text Available This paper summarizes the development of a robotic system for the approximation of inertia tensor of micro‐sized rigid bodies. We described the design and computer‐based simulation of a 6‐DOF motion platform in our earlier work [32] that benefits from an anthropological serial manipulator design. In [32] we emphasized that, in contrast to a standard configuration based on linear actuators, a mechanism with actuator design inspired from an anthropological kinematic structure offers relatively a larger motion envelope and higher dexterity making it a viable motion platform for micromanipulations. After having described the basic design and kinematic analysis of our motion platform in [32], we now aim to propose an advanced motion cueing algorithm for facilitating the identification of inertial parameters at micron‐level. The motion cueing algorithm for achieving high fidelity dynamic simulation is described in this paper using a hybrid force‐position‐based controller. The inertia tensor identification is done by generating a controlled motion on the specimen and measuring the resultant forces and moments to approximate the inertia tensor using rigid body dynamics equations. The paper evaluates the performance of the controller using closed‐loop dynamic simulations and validates the significance of the proposed method through experimental results.

  6. Preparation and characterization of humic acid-carbon hybrid materials as adsorbents for organic micro-pollutants.

    Science.gov (United States)

    Radwan, Emad K; Abdel Ghafar, Hany H; Moursy, Ahmed S; Langford, Cooper H; Bedair, Ahmed H; Achari, Gopal

    2015-08-01

    The present work involves the preparation of novel adsorbent materials by the insolubilization and hybridization of humic acid (HA) with carbon. The prepared materials were characterized by N2 adsorption, elemental analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, solid-state (13)C cross polarization magic angle spinning nuclear magnetic resonance, and low-field nuclear magnetic resonance (NMR) relaxometry on wetted samples. The water solubility of these materials and the lack of effect of oxidants were also confirmed. With this background, the adsorption capacities toward phenol, 2,4,6-tricholrophenol, and atrazine were evaluated, using these as model compounds for organic micropollutants of concern in water. Experimental results show that the prepared materials are mesoporous and have a higher surface area than humic acid and even than the porous carbon in the case of carbon coating. They retain the basic features of the starting materials with lowered functional group content. Moreover, there are interesting new features. NMR relaxometry shows that equilibration of water uptake is very fast, making use in water simple. They have higher adsorption capacities than the pure materials, and they can be applied under a wide range of environmental conditions.

  7. Analytic Models of Plausible Gravitational Lens Potentials

    Energy Technology Data Exchange (ETDEWEB)

    Baltz, Edward A.; Marshall, Phil; Oguri, Masamune

    2007-05-04

    Gravitational lenses on galaxy scales are plausibly modeled as having ellipsoidal symmetry and a universal dark matter density profile, with a Sersic profile to describe the distribution of baryonic matter. Predicting all lensing effects requires knowledge of the total lens potential: in this work we give analytic forms for that of the above hybrid model. Emphasizing that complex lens potentials can be constructed from simpler components in linear combination, we provide a recipe for attaining elliptical symmetry in either projected mass or lens potential.We also provide analytic formulae for the lens potentials of Sersic profiles for integer and half-integer index. We then present formulae describing the gravitational lensing effects due to smoothly-truncated universal density profiles in cold dark matter model. For our isolated haloes the density profile falls off as radius to the minus fifth or seventh power beyond the tidal radius, functional forms that allow all orders of lens potential derivatives to be calculated analytically, while ensuring a non-divergent total mass. We show how the observables predicted by this profile differ from that of the original infinite-mass NFW profile. Expressions for the gravitational flexion are highlighted. We show how decreasing the tidal radius allows stripped haloes to be modeled, providing a framework for a fuller investigation of dark matter substructure in galaxies and clusters. Finally we remark on the need for finite mass halo profiles when doing cosmological ray-tracing simulations, and the need for readily-calculable higher order derivatives of the lens potential when studying catastrophes in strong lenses.

  8. Segmentation of 3D microPET images of the rat brain via the hybrid gaussian mixture method with kernel density estimation.

    Science.gov (United States)

    Chen, Tai-Been; Chen, Jyh-Cheng; Lu, Henry Horng-Shing

    2012-01-01

    Segmentation of positron emission tomography (PET) is typically achieved using the K-Means method or other approaches. In preclinical and clinical applications, the K-Means method needs a prior estimation of parameters such as the number of clusters and appropriate initialized values. This work segments microPET images using a hybrid method combining the Gaussian mixture model (GMM) with kernel density estimation. Segmentation is crucial to registration of disordered 2-deoxy-2-fluoro-D-glucose (FDG) accumulation locations with functional diagnosis and to estimate standardized uptake values (SUVs) of region of interests (ROIs) in PET images. Therefore, simulation studies are conducted to apply spherical targets to evaluate segmentation accuracy based on Tanimoto's definition of similarity. The proposed method generates a higher degree of similarity than the K-Means method. The PET images of a rat brain are used to compare the segmented shape and area of the cerebral cortex by the K-Means method and the proposed method by volume rendering. The proposed method provides clearer and more detailed activity structures of an FDG accumulation location in the cerebral cortex than those by the K-Means method.

  9. Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification.

    Science.gov (United States)

    Silahtaroglu, Asli N; Nolting, Dorrit; Dyrskjøt, Lars; Berezikov, Eugene; Møller, Morten; Tommerup, Niels; Kauppinen, Sakari

    2007-01-01

    The ability to determine spatial and temporal microRNA (miRNA) accumulation at the tissue, cell and subcellular levels is essential for understanding the biological roles of miRNAs and miRNA-associated gene regulatory networks. This protocol describes a method for fast and effective detection of miRNAs in frozen tissue sections using fluorescence in situ hybridization (FISH). The method combines the unique miRNA recognition properties of locked nucleic acid (LNA)-modified oligonucleotide probes with FISH using the tyramide signal amplification (TSA) technology. Although both approaches have previously been shown to increase detection sensitivity in FISH, combining these techniques into one protocol significantly decreases the time needed for miRNA detection in cryosections, while simultaneously retaining high detection sensitivity. Starting with fixation of the tissue sections, this miRNA FISH protocol can be completed within approximately 6 h and allows miRNA detection in a wide variety of animal tissue cryosections as well as in human tumor biopsies at high cellular resolution.

  10. Effect of surface treatments on the tensile bond strength of repaired water-aged anterior restorative micro-fine hybrid resin composite.

    Science.gov (United States)

    Fawzy, Amr S; El-Askary, Farid S; Amer, Mohamed A

    2008-12-01

    The purpose of this study was to characterize changes in surface topography associated with different surface treatments and their effect on tensile bond strength (TBS) of repaired water-aged anterior restorative micro-fine hybrid resin composite. The TBS of repaired resin-based composite slabs either non-treated or exposed to different mechanical and/or chemical surface treatment procedures were measured. The cohesive tensile strength of non-repaired intact slabs was used as a control group. The topographical effects of acid etching, grinding, and grinding followed by acid etching were characterized by AFM and SEM. All repaired groups showed significantly lower TBS than the control group. The TBS of repaired groups was ranged from 15% to 59% of the cohesive tensile strength of the control group (18.8+/-4.5MPa). The surface roughness of the non-treated aged specimens was significantly higher than other treated specimens. Specimens treated by acid etching showed significant increase in surface area compared to the non-treated and treated specimens. Aging process resulted in the formation of degradable surface layer which adversely affects the repair bond strength. The use of silane primer prior to the application of the adhesive after mechanical grinding, with or without the use of 37% phosphoric acid etching; improves the repair bond strength.

  11. Colored Contact Lens Dangers

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  1. Colored Contact Lens Dangers

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    Full Text Available ... Healthy Contact Lens Use May 31, 2016 Is El Niño Making Your Allergies Worse? May 16, 2016 ... Number: * Email: * Enter code: * Message: Thank you Your feedback has been sent.

  4. Development of a novel mixed hemimicelles dispersive micro solid phase extraction using 1-hexadecyl-3-methylimidazolium bromide coated magnetic graphene for the separation and preconcentration of fluoxetine in different matrices before its determination by fiber optic linear array spectrophotometry and mode-mismatched thermal lens spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Kazemi, Elahe; Haji Shabani, Ali Mohammad [Department of Chemistry, Yazd University, Safaieh, 89195-741, Yazd (Iran, Islamic Republic of); Dadfarnia, Shayessteh, E-mail: sdadfarnia@yazd.ac.ir [Department of Chemistry, Yazd University, Safaieh, 89195-741, Yazd (Iran, Islamic Republic of); Abbasi, Amir [Department of Physics, Yazd University, Safaieh, 89195-741, Yazd (Iran, Islamic Republic of); Rashidian Vaziri, Mohammad Reza [Laser and Optics Research School, 14155-1339, Tehran (Iran, Islamic Republic of); Behjat, Abbas [Department of Physics, Yazd University, Safaieh, 89195-741, Yazd (Iran, Islamic Republic of)

    2016-01-28

    This study aims at developing a novel, sensitive, fast, simple and convenient method for separation and preconcentration of trace amounts of fluoxetine before its spectrophotometric determination. The method is based on combination of magnetic mixed hemimicelles solid phase extraction and dispersive micro solid phase extraction using 1-hexadecyl-3-methylimidazolium bromide coated magnetic graphene as a sorbent. The magnetic graphene was synthesized by a simple coprecipitation method and characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). The retained analyte was eluted using a 100 μL mixture of methanol/acetic acid (9:1) and converted into fluoxetine-β-cyclodextrin inclusion complex. The analyte was then quantified by fiber optic linear array spectrophotometry as well as mode-mismatched thermal lens spectroscopy (TLS). The factors affecting the separation, preconcentration and determination of fluoxetine were investigated and optimized. With a 50 mL sample and under optimized conditions using the spectrophotometry technique, the method exhibited a linear dynamic range of 0.4–60.0 μg L{sup −1}, a detection limit of 0.21 μg L{sup −1}, an enrichment factor of 167, and a relative standard deviation of 2.1% and 3.8% (n = 6) at 60 μg L{sup −1} level of fluoxetine for intra- and inter-day analyses, respectively. However, with thermal lens spectrometry and a sample volume of 10 mL, the method exhibited a linear dynamic range of 0.05–300 μg L{sup −1}, a detection limit of 0.016 μg L{sup −1} and a relative standard deviation of 3.8% and 5.6% (n = 6) at 60 μg L{sup −1} level of fluoxetine for intra- and inter-day analyses, respectively. The method was successfully applied to determine fluoxetine in pharmaceutical formulation, human urine and environmental water samples. - Graphical abstract: A novel, sensitive, fast, simple and convenient mixed hemimicelles

  5. Research on Application of Hybrid Energy Storage Technology in Photoelectric Micro-Power Supply%混合能量存储技术在光电微能源中的应用研究

    Institute of Scientific and Technical Information of China (English)

    何永泰; 肖丽仙; 李雷; 刘晋豪

    2016-01-01

    为简化集成无线传感器节点光电微能源系统的设计和提高能量转换、存储效率,提出混合能量存储技术在光电微能源系统设计中的应用.混合能量存储器由电容器和锂离子电池组成.其能量存储原理负载特性被分析.另外,开展实验研究,结果表明,与直接能量存储方式相比,利用混合能量存储技术能量存储量提高27%.并且,微能源的负载特性也得到改善,实验结果与理论结果一致.%In the design of the photoelectric micro-power supply integrated with wireless sensor nodes,the hybrid energy storage technology was adopted to simplify the system design and to improve the performance of the energy conversion and storage for photoelectric micro-power supply which consists of the lithium ion battery and the super capacitor. This paper introduced the principle of solar energy conversion and storage in the hybrid energy storage technology,and analyzed the load characteristics of hybrid energy storage technology. In addition,the characteris-tics of the hybrid energy storage were studied by experiment,which showed that the storage energy of photovoltaic cell output power was increased by roughly 27%by using hybrid energy storage method instead of useing the direct energy storage method,and the load characteristics of the photovoltaic micro-power supply was also improved. The experimental results were consistent with the theory analysis conclusion.

  6. The comparison of the effects of different whitening toothpastes on the micro hardness of a nano hybrid composite resin

    Directory of Open Access Journals (Sweden)

    Mohan Thomas Nainan

    2014-01-01

    Full Text Available Aim: The aim of this study was to compare the micro hardness of a nanohybrid composite resin after brushing with two herbal and one non-herbal whitening toothpastes. Materials and Methods: We divided Eighty disk-shaped specimens of a nanohybrid composite (Tetric N Ceram, Ivoclar Vivadent, Asia into 4 groups of 20 specimens each: Groups A, B, C, and D. Group A was control, Group B was brushed with Colgate total advanced whitening (Colgate-Palmolive (India Limited, Group C with Salt and Lemon, Dabur (Dabur International Limited, Dubai, UAE, and Group D with HiOra Shine, Himalaya (The Himalaya Drug Company, India. The specimens were polished using medium, fine, and superfine discs (Sof-lex, 3M, ESPE, USA and subsequently placed at 37°C in distilled water. They were brushed for 2 minutes twice daily with a soft motorized toothbrush (Colgate 360 sonic power battery-operated tooth brush, Colgate Palmolive, India for 30 days. The samples were rinsed under running water to remove the toothpaste and stored in distilled water at 37°C until the readout was taken on the Vickers′s hardness tester for microhardness. Results: The results revealed that the difference among the groups was statistically significant (P < 0.001. Tukey′s test showed that reduction in microhardness for Group B was significantly higher than that for Group C and Group D (P < 0.001. Conclusion: Within the limitations of this study, non-herbal whitening toothpaste had a greater impact on the microhardness of nanohybrid resin composite than herbal whitening toothpastes.

  7. The comparison of the effects of different whitening toothpastes on the micro hardness of a nano hybrid composite resin.

    Science.gov (United States)

    Nainan, Mohan Thomas; Balan, Ashok Kalappurakkal; Sharma, Roshni; Thomas, Sabeena Susan; Deveerappa, Santhosh B

    2014-11-01

    The aim of this study was to compare the micro hardness of a nanohybrid composite resin after brushing with two herbal and one non-herbal whitening toothpastes. We divided Eighty disk-shaped specimens of a nanohybrid composite (Tetric N Ceram, Ivoclar Vivadent, Asia) into 4 groups of 20 specimens each: Groups A, B, C, and D. Group A was control, Group B was brushed with Colgate total advanced whitening (Colgate-Palmolive (India) Limited), Group C with Salt and Lemon, Dabur (Dabur International Limited, Dubai, UAE), and Group D with HiOra Shine, Himalaya (The Himalaya Drug Company, India). The specimens were polished using medium, fine, and superfine discs (Sof-lex, 3M, ESPE, USA) and subsequently placed at 37°C in distilled water. They were brushed for 2 minutes twice daily with a soft motorized toothbrush (Colgate 360 sonic power battery-operated tooth brush, Colgate Palmolive, India) for 30 days. The samples were rinsed under running water to remove the toothpaste and stored in distilled water at 37°C until the readout was taken on the Vickers's hardness tester for microhardness. The results revealed that the difference among the groups was statistically significant (P < 0.001). Tukey's test showed that reduction in microhardness for Group B was significantly higher than that for Group C and Group D (P < 0.001). Within the limitations of this study, non-herbal whitening toothpaste had a greater impact on the microhardness of nanohybrid resin composite than herbal whitening toothpastes.

  8. TU-E-201-03: Eye Lens Dosimetry in Radiotherapy Using Contact Lens-Shaped Applicator

    Energy Technology Data Exchange (ETDEWEB)

    Park, J. [Seoul National University Hospital (Korea, Republic of)

    2015-06-15

    . These actions should be considered when they are consistent with the clinical task and patient anatomy. Learning Objectives: To become familiar with method of eye dose estimation for patient in specific situation of brain perfusion CT To become familiar with level of eye lens radiation doses in patients undergoing brain perfusion MDCT To understand methods for reducing eye lens dose to patient Jong Min Park, Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea Eye lens dosimetry in radiotherapy using contact lens-shaped applicator Dose calculation accuracy of commercial treatment planning systems is relatively low at shallow depths. Therefore, in-vivo measurements are often performed in the clinic to verify delivered doses to eye lens which are located at shallow depth. Current in-vivo dosimetry for eye lens during radiotherapy is generally performed with small in-vivo dosimeters on the surface of patient eyelid. Since this procedure potentially contains considerable uncertainty, a contact lens-shaped applicator made of acrylic (lens applicator) was developed for in-vivo measurements of eye lens dose during radiotherapy to reduce uncertainty. The lens applicator allows the insertion of commercially available metal oxide semiconductor field effect transistor (MOSFET) dosimeters. Computed tomography (CT) images of an anthropomorphic phantom with and without the lens applicator were acquired. A total of 20 VMAT plans were delivered to an anthropomorphic phantom and the doses with the lens applicator and the doses at the surface of the eyelid were measured using both micro and standard MOSFET dosimeters. The differences in measured dose at the surface of the eyelid from the calculated lens dose were acquired. The differences between the measured and the calculated doses at the lens applicator, as well as the differences between the measured and the calculated doses at the surface of the eyelid were acquired. The statistical significance of the

  9. TU-E-201-01: Methods for Eye Lens Dosimetry and Studies On Lens Opacities with Interventionists

    Energy Technology Data Exchange (ETDEWEB)

    Rehani, M. [Massachusetts General Hospital (United States)

    2015-06-15

    . These actions should be considered when they are consistent with the clinical task and patient anatomy. Learning Objectives: To become familiar with method of eye dose estimation for patient in specific situation of brain perfusion CT To become familiar with level of eye lens radiation doses in patients undergoing brain perfusion MDCT To understand methods for reducing eye lens dose to patient Jong Min Park, Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea Eye lens dosimetry in radiotherapy using contact lens-shaped applicator Dose calculation accuracy of commercial treatment planning systems is relatively low at shallow depths. Therefore, in-vivo measurements are often performed in the clinic to verify delivered doses to eye lens which are located at shallow depth. Current in-vivo dosimetry for eye lens during radiotherapy is generally performed with small in-vivo dosimeters on the surface of patient eyelid. Since this procedure potentially contains considerable uncertainty, a contact lens-shaped applicator made of acrylic (lens applicator) was developed for in-vivo measurements of eye lens dose during radiotherapy to reduce uncertainty. The lens applicator allows the insertion of commercially available metal oxide semiconductor field effect transistor (MOSFET) dosimeters. Computed tomography (CT) images of an anthropomorphic phantom with and without the lens applicator were acquired. A total of 20 VMAT plans were delivered to an anthropomorphic phantom and the doses with the lens applicator and the doses at the surface of the eyelid were measured using both micro and standard MOSFET dosimeters. The differences in measured dose at the surface of the eyelid from the calculated lens dose were acquired. The differences between the measured and the calculated doses at the lens applicator, as well as the differences between the measured and the calculated doses at the surface of the eyelid were acquired. The statistical significance of the

  10. Dielectric Optical-Controllable Magnifying Lens by Nonlinear Negative Refraction

    Science.gov (United States)

    Cao, Jianjun; Shang, Ce; Zheng, Yuanlin; Feng, Yaming; Chen, Xianfeng; Liang, Xiaogan; Wan, Wenjie

    2015-01-01

    A simple optical lens plays an important role for exploring the microscopic world in science and technology by refracting light with tailored spatially varying refractive indices. Recent advancements in nanotechnology enable novel lenses, such as, superlens and hyperlens, with sub-wavelength resolution capabilities by specially designed materials’ refractive indices with meta-materials and transformation optics. However, these artificially nano- or micro-engineered lenses usually suffer high losses from metals and are highly demanding in fabrication. Here, we experimentally demonstrate, for the first time, a nonlinear dielectric magnifying lens using negative refraction by degenerate four-wave mixing in a plano-concave glass slide, obtaining magnified images. Moreover, we transform a nonlinear flat lens into a magnifying lens by introducing transformation optics into the nonlinear regime, achieving an all-optical controllable lensing effect through nonlinear wave mixing, which may have many potential applications in microscopy and imaging science. PMID:26149952

  11. Perforation forces of the intact porcine anterior lens capsule.

    Science.gov (United States)

    Ullrich, Franziska; Lussi, Jonas; Felekis, Dimitrios; Michels, Stephan; Petruska, Andrew J; Nelson, Bradley J

    2016-09-01

    During the first step of cataract surgery, the lens capsule is perforated and a circular hole is created with a sharp instrument, a procedure called capsulorhexis. To develop automated systems that can assist ophthalmologists during capsulorhexis, the forces required must be quantified. This study investigates perforation forces of the central anterior lens capsule in porcine eyes, which are used as a conservative model for the human eye. A micro-mechanical characterisation method is presented that measures capsular bag perforation forces with a high precision positioning and high-resolution force sensing system. The force during perforation of the anterior lens capsule was measured with various sized needles and indentation speeds and is found to be 15-35mN. A bio-mechanical model is identified that describes an exponential correlation between indentation force and depth, indicating strain hardening behaviour of the porcine anterior lens capsule.

  12. Effect of micro-nano-hybrid structured hydroxyapatite bioceramics on osteogenic and cementogenic differentiation of human periodontal ligament stem cell via Wnt signaling pathway

    Directory of Open Access Journals (Sweden)

    Mao LX

    2015-11-01

    Full Text Available Lixia Mao,1,* Jiaqiang Liu,1,* Jinglei Zhao,1 Jiang Chang,2 Lunguo Xia,1 Lingyong Jiang,1 Xiuhui Wang,2 Kaili Lin,2,3 Bing Fang11Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Science, Top Priority Clinical Medical Center of Shanghai Municipal Commission of Health and Family Planning, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, 2State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 3Shanghai Engineering Research Center of Tooth Restoration and Regeneration, School of Stomatology, Tongji University, Shanghai, People’s Republic of China*These authors contributed equally to this workAbstract: The surface structure of bioceramic scaffolds is crucial for its bioactivity and osteoinductive ability, and in recent years, human periodontal ligament stem cells have been certified to possess high osteogenic and cementogenic differential ability. In the present study, hydroxyapatite (HA bioceramics with micro-nano-hybrid surface (mnHA [the hybrid of nanorods and microrods] were fabricated via hydrothermal reaction of the α-tricalcium phosphate granules as precursors in aqueous solution, and the effects of mnHA on the attachment, proliferation, osteogenic and cementogenic differentiations of human periodontal ligament stem cells as well as the related mechanisms were systematically investigated. The results showed that mnHA bioceramics could promote cell adhesion, proliferation, alkaline phosphatase (ALP activity, and expression of osteogenic/cementogenic-related markers including runt-related transcription factor 2 (Runx2, ALP, osteocalcin (OCN, cementum attachment protein (CAP, and cementum protein (CEMP as compared to the HA bioceramics with flat and dense surface. Moreover, mnHA bioceramics stimulated gene expression of low-density lipoprotein receptor

  13. Micro and nano-biomimetic structures for cell migration study fabricated by hybrid subtractive and additive 3D femtosecond laser processing

    Science.gov (United States)

    Sima, Felix; Serien, Daniela; Wu, Dong; Xu, Jian; Kawano, Hiroyuki; Midorikawa, Katsumi; Sugioka, Koji

    2017-02-01

    Lab-on-a-chip devices have been intensively developed during the last decade when emerging technologies offered possibilities to manufacture reliable devices with increased spatial resolution. These biochips allowed testing chemical reactions in nanoliter volumes with enhanced sensitivity and lower consumption of reagents. There is space to further consolidate biochip assembling processing since the new technologies attempt direct fabrication in view of reducing costs and time by increasing efficiency and functionalities. Rapid prototyping by ultrafast lasers which induces local modifications inside transparent materials of both glass and polymers with high precision at micro- and nanoscale is a promising tool for fabrication of such biochips. We have developed a new technology by combining subtractive ultrafast laser assisted chemical etching of glasses and additive two-photon polymerization to integrate 3D glass microfluidics and polymer microcomponents in a single biochip. The innovative hybrid "ship-in-a-bottle" approach is not only an instrument that can tailor 3D environments but also a tool to fabricate biomimetic in vivo structures inside a glass microfluidic chip. It was possible to create appropriate environment for cell culturing and to offer robustness and transparency for optical interrogation. Cancer cells were cultivated inside biochips and monitored over short and long periods. With the view of understanding cancer cells specific behavior such as migration or invasiveness inside human body, introduction of different geometrical configurations and chemical conditions were proposed. The cells were found responsive to a gradient of nutrient concentration through the microchannels of a 3D polymeric scaffold integrated inside glass biochip.

  14. Liquid Hybridization and Solid Phase Detection: A Highly Sensitive and Accurate Strategy for MicroRNA Detection in Plants and Animals

    Directory of Open Access Journals (Sweden)

    Fosheng Li

    2016-09-01

    Full Text Available MicroRNAs (miRNAs play important roles in nearly every aspect of biology, including physiological, biochemical, developmental and pathological processes. Therefore, a highly sensitive and accurate method of detection of miRNAs has great potential in research on theory and application, such as the clinical approach to medicine, animal and plant production, as well as stress response. Here, we report a strategic method to detect miRNAs from multicellular organisms, which mainly includes liquid hybridization and solid phase detection (LHSPD; it has been verified in various species and is much more sensitive than traditional biotin-labeled Northern blots. By using this strategy and chemiluminescent detection with digoxigenin (DIG-labeled or biotin-labeled oligonucleotide probes, as low as 0.01–0.25 fmol [for DIG-CDP Star (disodium2-chloro-5-(4-methoxyspiro{1,2-dioxetane-3,2′-(5′-chlorotricyclo[3.3.1.13,7]decan}-4-ylphenyl phosphate system], 0.005–0.1 fmol (for biotin-CDP Star system, or 0.05–0.5 fmol (for biotin-luminol system of miRNA can be detected and one-base difference can be distinguished between miRNA sequences. Moreover, LHSPD performed very well in the quantitative analysis of miRNAs, and the whole process can be completed within about 9 h. The strategy of LHSPD provides an effective solution for rapid, accurate, and sensitive detection and quantitative analysis of miRNAs in plants and animals.

  15. Label-Free and Enzyme-Free Homogeneous Electrochemical Biosensing Strategy Based on Hybridization Chain Reaction: A Facile, Sensitive, and Highly Specific MicroRNA Assay.

    Science.gov (United States)

    Hou, Ting; Li, Wei; Liu, Xiaojuan; Li, Feng

    2015-11-17

    Homogenous electrochemical biosensing strategies have attracted substantial attention, because of their advantages of being immobilization-free and having rapid response and improved recognition efficiency, compared to heterogeneous biosensors; however, the high cost of labeling and the strict reaction conditions of tool enzymes associated with current homogeneous electrochemical methods limit their potential applications. To address these issues, herein we reported, for the first time, a simple label-free and enzyme-free homogeneous electrochemical strategy based on hybridization chain reaction (HCR) for sensitive and highly specific detection of microRNA (miRNA). The target miRNA triggers the HCR of two species of metastable DNA hairpin probes, resulting in the formation of multiple G-quadruplex-incorporated long duplex DNA chains. Thus, with the electrochemical indicator Methylene Blue (MB) selectively intercalated into the duplex DNA chain and the multiple G-quadruplexes, a significant electrochemical signal drop is observed, which is dependent on the concentration of the target miRNA. Thus, using this "signal-off" mode, a simple, label-free and enzyme-free homogeneous electrochemical strategy for sensitive miRNA assay is readily realized. This strategy also exhibits excellent selectivity to distinguish even single-base mismatched miRNA. Furthermore, this method also exhibits additional advantages of simplicity and low cost, since both expensive labeling and sophisticated probe immobilization processes are avoided. Therefore, the as-proposed label-free and enzyme-free homogeneous electrochemical strategy may become an alternative method for simple, sensitive, and selective miRNA detection, and it has great potential to be applied in miRNA-related clinical diagnostics and biochemical research.

  16. Thin Lens Ray Tracing.

    Science.gov (United States)

    Gatland, Ian R.

    2002-01-01

    Proposes a ray tracing approach to thin lens analysis based on a vector form of Snell's law for paraxial rays as an alternative to the usual approach in introductory physics courses. The ray tracing approach accommodates skew rays and thus provides a complete analysis. (Author/KHR)

  17. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... Lens Use May 31, 2016 Is El Niño Making Your Allergies Worse? May 16, 2016 More Eye ... EyeSmart Embed EyeSmart videos on your website Promotional materials for eye health observances EyeSmart resources are also ...

  18. Impedance of goat eye lens at different DC voltages.

    Science.gov (United States)

    Kohli, K S; Rai, D V; Jindal, V K; Goyal, N

    1998-09-01

    A computer assisted AC impedance system is used to measure the DC voltage-current (V-I) characteristics and AC impedance of a goat eye lens using a two-probe Ag-AgCl electrode system. The measurement of the V-I characteristics shows that when a DC voltage from 0 mV to 30 mV is applied, the resultant current decreases from an initial value of 0.58 microA to 0.006 microA. However, when the voltage is increases beyond 30 mV, the current increases and reaches a value of 0.9 microA at 100 mV. The data on the frequency response (0.01-10 Hz) of the impedance of lens tissue show an inverse relationship with frequency. The effect of various DC voltages, namely 0, 30, 50, 100 and 200 mV, on the impedance of the eye lens is also investigated over a frequency range of 0.01-10 Hz. The measurement results for both V-I characteristics and AC impedance further suggest the presence of a 30 mV voltage compartment in the goat eye lens.

  19. Fusion of protoplasts with irradiated micro protoplasts as a tool for radiation hybrid panel in citrus;Fusao de protoplastos com microprotoplastos irradiados como ferramenta para painel hibrido de radiacao em citros

    Energy Technology Data Exchange (ETDEWEB)

    Bona, Claudine Maria de, E-mail: debona@iapar.b [Instituto Agronomico do Parana (IAPAR), Curitiba, PR (Brazil). Centro Administrativo do Governo do Estado; Stelly, David, E-mail: stelly@tamu.ed [Texas A and M University (Tamu), College Station, TX (United States). Dept. of Soil and Crop Sciences; Miller Junior, J. Creighton, E-mail: jcmillerjr@tamu.ed [Texas A and M University (Tamu), College Station, TX (United States). Dept. of Horticultural Sciences; Louzada, Eliezer Silva, E-mail: elouzada@ag.tamu.ed [Texas A and M University, (Tamuk), Weslaco, TX (United States)

    2009-12-15

    The objective of this work was to combine asymmetric somatic hybridization (donor-recipient fusion or gamma fusion) to microprotoplast-mediated chromosome transfer, as a tool to be used for chromosome mapping in Citrus. Swinglea glutinosa micro protoplasts were irradiated either with 50, 70, 100 or 200 gamma rays and fused to cv. Ruby Red grapefruit or Murcott tangor protoplasts. Cell colonies were successfully formed and AFLP analyses confirmed presence of S. glutinosa in both 'Murcott' tangor and 'Ruby Red' grapefruit genomes. (author)

  20. Electron optics of skewed micro-Einzel lenses

    NARCIS (Netherlands)

    Van Bruggen, M.J.; Van Someren, B.; Kruit, P.

    2009-01-01

    Micro-Einzel lenses always suffer from chromatic and spherical aberration, even when the electron beam is exactly on the optical axis of the lens. When the inclination of the electron beam with respect to the lens axis increases, additional effects such as coma, astigmatism, and defocus start to dom

  1. LASER INDUCED THERMAL LENS EFFECT

    Institute of Scientific and Technical Information of China (English)

    沈俊; 黄孟才; 江景云; 施教芳

    1991-01-01

    The thermal lens effect has emerged in recent years as a novel ,highly sensitive tool for the study of the very weak molecular absorption of light energy,This paper discusses the theory and technique of the thermal lens measurement.Some opplications of the thermal lens measurement are described.A mode-mismatched dual-beam thermal lens experimental arragement with a modulated probe beam ,designed by the authors.for trace analysis is presented,and its detection limit was found to be 4.1×10-7 for Cu(Ⅱ) in ethanol and 80 mW excitation power.

  2. Modeling and Verification of Hybrid Energy Storage System Based on Micro Compressed Air Energy Storage%基于微型压缩空气储能的混合储能系统建模与实验验证

    Institute of Scientific and Technical Information of China (English)

    王成山; 武震; 杨献莘; 张书槐; 刘一欣

    2014-01-01

    The micro compressed air energy storage system is a new type of energy storage systems capable of being combined with flywheel to form a hybrid energy storage system.The structure and principle of a hybrid energy storage system based on micro compressed air energy storage is described.The governor system model of micro compressed air energy storage is proposed based on the experimental data,which simulates the dynamics of pressure,temperature,valve,and turbine and so on.Finally,a comparison between experimental data and simulation results is given to verify the applicability and effectiveness of the proposed model. This work is supported by National Basic Research Program of China(973 Program)(No.2009CB219700).%微型压缩空气储能是一种新型的储能技术,可以与飞轮等组成混合储能系统。文中介绍了基于微型压缩空气储能的混合储能系统的结构及工作原理,根据现有设备的实验结果提出了压缩空气储能原动部分的数学模型,包括压缩空气压力、温度、阀门、透平等环节,并通过拟合的方法进行参数辨识。最后,搭建了混合储能系统的仿真算例,并通过仿真与实验数据的对比验证了模型的适用性和有效性。

  3. Physics of electrostatic lens

    Science.gov (United States)

    1981-09-01

    The purpose of this program was to study the physics of the ion-energy boosting electrostatic lens for collective ion acceleration in the Luce diode. Extensive work was done in preparation for experiments on the PI Pulserad 1150. Analytic work was done on the orbit of protons in a mass spectrometer and a copper stack for nuclear activation analysis of proton energy spectrum has been designed. Unfortunately, a parallel program which would provide the Luce diode for the collective ion acceleration experiment never materialized. As a result no experiments were actually performed on the Pulserad 1150.

  4. [Intraocular lens implantation in developmental lens disorders in children].

    Science.gov (United States)

    Kanigowska, Krystyna; Grałek, Mirosława; Kepa, Beata; Chipczyńska, Barbara

    2009-01-01

    The pediatric cataract surgery in eyes with developmental disorders, stay with still considerable challenge. At children, the lasting vision development extorts necessity quick settlement of refraction defect formed after operation. The intraocular lens old boy with cataract in microspherophakia and 12 years old boy with cataract in lens with coloboma. One-piece flexible and rigid PMMA intraocular lens was placed with success at posterior chamber without scleral fixations and without using capsular tension ring in this cases. After 3 years of observation there were no decentration or dislocation of intraocular lens in both children. Authors concluded that in some cases posterior chamber intraocular lens implantation despite defective zonular or capsular support, can make up the effective method of surgical treatment without risk of early dislocation.

  5. Panoramic lens applications revisited

    Science.gov (United States)

    Thibault, Simon

    2008-04-01

    During the last few years, innovative optical design strategies to generate and control image mapping have been successful in producing high-resolution digital imagers and projectors. This new generation of panoramic lenses includes catadioptric panoramic lenses, panoramic annular lenses, visible/IR fisheye lenses, anamorphic wide-angle attachments, and visible/IR panomorph lenses. Given that a wide-angle lens images a large field of view on a limited number of pixels, a systematic pixel-to-angle mapping will help the efficient use of each pixel in the field of view. In this paper, we present several modern applications of these modern types of hemispheric lenses. Recently, surveillance and security applications have been proposed and published in Security and Defence symposium. However, modern hemispheric lens can be used in many other fields. A panoramic imaging sensor contributes most to the perception of the world. Panoramic lenses are now ready to be deployed in many optical solutions. Covered applications include, but are not limited to medical imaging (endoscope, rigiscope, fiberscope...), remote sensing (pipe inspection, crime scene investigation, archeology...), multimedia (hemispheric projector, panoramic image...). Modern panoramic technologies allow simple and efficient digital image processing and the use of standard image analysis features (motion estimation, segmentation, object tracking, pattern recognition) in the complete 360° hemispheric area.

  6. Resolving colocalization of bacteria and metal(loid)s on plant root surfaces by combining fluorescence in situ hybridization (FISH) with multiple-energy micro-focused X-ray fluorescence (ME μXRF).

    Science.gov (United States)

    Honeker, Linnea K; Root, Robert A; Chorover, Jon; Maier, Raina M

    2016-12-01

    Metal(loid)-contamination of the environment due to anthropogenic activities is a global problem. Understanding the fate of contaminants requires elucidation of biotic and abiotic factors that influence metal(loid) speciation from molecular to field scales. Improved methods are needed to assess micro-scale processes, such as those occurring at biogeochemical interfaces between plant tissues, microbial cells, and metal(loid)s. Here we present an advanced method that combines fluorescence in situ hybridization (FISH) with synchrotron-based multiple-energy micro-focused X-ray fluorescence microprobe imaging (ME μXRF) to examine colocalization of bacteria and metal(loid)s on root surfaces of plants used to phytostabilize metalliferous mine tailings. Bacteria were visualized on a small root section using SytoBC nucleic acid stain and FISH probes targeting the domain Bacteria and a specific group (Alphaproteobacteria, Gammaproteobacteria, or Actinobacteria). The same root region was then analyzed for elemental distribution and metal(loid) speciation of As and Fe using ME μXRF. The FISH and ME μXRF images were aligned using ImageJ software to correlate microbiological and geochemical results. Results from quantitative analysis of colocalization show a significantly higher fraction of As colocalized with Fe-oxide plaques on the root surfaces (fraction of overlap 0.49±0.19) than to bacteria (0.072±0.052) (pbacteria that colocalized with metal(loid)s, Actinobacteria, known for their metal tolerance, had a higher correlation with both As and Fe than Alphaproteobacteria or Gammaproteobacteria. This method demonstrates how coupling these micro-techniques can expand our understanding of micro-scale interactions between roots, metal(loid)s and microbes, information that should lead to improved mechanistic models of metal(loid) speciation and fate. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Design of hybrid optical tweezers system for controlled three-dimensional micromanipulation

    Science.gov (United States)

    Tanaka, Yoshio; Tsutsui, Shogo; Kitajima, Hiroyuki

    2013-04-01

    Three-dimensional (3D) micro/nano-manipulation using optical tweezers is a significant technique for various scientific fields ranging from biology to nanotechnology. For the dynamic handling of multiple/individual micro-objects in a true 3D working space, we present an improved hybrid optical tweezers system consisting of two multibeam techniques. These two techniques include the generalized phase contrast method with a spatial light modulator and the time-shared scanning method with a two-axis steering mirror and an electrically focus-tunable lens. Unlike our previously reported system that could only handle micro-objects in a two and half dimensional working space, the present system has high versatility for controlled manipulation of multiple micro-objects in a true 3D working space. The controlled rotation of five beads forming a pentagon, that of four beads forming a tetrahedron about arbitrary axes, and the fully automated assembly and subsequent 3D translation of micro-bead arrays are successfully demonstrated as part of the 3D manipulation experiment.

  8. Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens

    Science.gov (United States)

    Near, Richard I.; Smith, Richard S.; Toselli, Paul A.; Freddo, Thomas F.; Bloom, Alexander B.; Vanden Borre, Pierre; Seldin, David C.

    2009-01-01

    Purpose AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor dependence. We sought to establish the effects of the loss of AND-34 expression in a mammalian organism. Methods AND-34−/− mice were generated by homologous recombination. Histopathology, in situ hybridization, and western blotting were performed on murine tissues. Results Western analyses confirmed total loss of expression in AND-34−/− splenic lymphocytes. Mice lacking AND-34 are fertile and have normal longevity. While AND-34 is widely expressed in wild type mice, histologic analysis of multiple organs in AND-34−/− mice is unremarkable and analyses of lymphocyte development show no overt changes. A small percentage of AND-34−/− mice show distinctive small white eye lesions resulting from the migration of ruptured cortical lens tissue into the anterior chamber. Following initial vacuolization and liquefaction of the lens cortex first observed at postnatal day three, posterior lens rupture occurs in all AND-34−/− mice, beginning as early as three weeks and seen in all mice at three months. Western blot analysis and in situ hybridization confirmed the presence of AND-34 RNA and protein in lens epithelial cells, particularly at the lens equator. Prior data link AND-34 expression to the activation of Akt signaling. While Akt Ser 473 phosphorylation was readily detectable in AND-34+/+ lens epithelial cells, it was markedly reduced in the AND-34−/− lens epithelium. Basal levels of p130Cas phosphorylation were higher in AND-34+/+ than in AND-34−/− lens epithelium. Conclusions These results demonstrate the loss of AND-34 dysregulates focal adhesion complex signaling in lens epithelial cells and suggest that AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens. PMID:19365570

  9. Optimization of Micro Strip Array Antennas Using Hybrid Particle Swarm Optimizer with Breeding and Subpopulation for Maximum Side-Lobe Reduction

    Directory of Open Access Journals (Sweden)

    F. T. Bendimerad

    2008-12-01

    Full Text Available In this paper, a technique based on hybrid particle swarm optimiser with breeding and subpopulation is presented for optimal design of reconfigurable dual-beam linear array antennas and planar arrays. In the amplitudephase synthesis, the design of a reconfigurable dual-pattern antenna array is based on finding a common amplitude distribution that can generate either a pencil or sector beam power pattern, when the phase distribution of the array is modified appropriately. The goal of this study is to introduce the hybrid model to the electromagnetic community and demonstrate its great potential in electromagnetic optimizations.

  10. Integration of micro milling highspeed spindle on a microEDM-milling machine set-up

    DEFF Research Database (Denmark)

    De Grave, Arnaud; Hansen, Hans Nørgaard; Andolfatto, Loic

    2009-01-01

    In order to cope with repositioning errors and to combine the fast removal rate of micro milling with the precision and small feature size achievable with micro EDM milling, a hybrid micro-milling and micro-EDM milling centre was built and tested. The aim was to build an affordable set-up, easy...... by micro milling. Examples of test parts are shown and used as an experimental validation....

  11. Wafer-level fabrication of arrays of glass lens doublets

    Science.gov (United States)

    Passilly, Nicolas; Perrin, Stéphane; Albero, Jorge; Krauter, Johann; Gaiffe, Olivier; Gauthier-Manuel, Ludovic; Froehly, Luc; Lullin, Justine; Bargiel, Sylwester; Osten, Wolfgang; Gorecki, Christophe

    2016-04-01

    Systems for imaging require to employ high quality optical components in order to dispose of optical aberrations and thus reach sufficient resolution. However, well-known methods to get rid of optical aberrations, such as aspherical profiles or diffractive corrections are not easy to apply to micro-optics. In particular, some of these methods rely on polymers which cannot be associated when such lenses are to be used in integrated devices requiring high temperature process for their further assembly and separation. Among the different approaches, the most common is the lens splitting that consists in dividing the focusing power between two or more optical components. In here, we propose to take advantage of a wafer-level technique, devoted to the generation of glass lenses, which involves thermal reflow in silicon cavities to generate lens doublets. After the convex lens sides are generated, grinding and polishing of both stack sides allow, on the first hand, to form the planar lens backside and, on the other hand, to open the silicon cavity. Nevertheless, silicon frames are then kept and thinned down to form well-controlled and auto-aligned spacers between the lenses. Subsequent accurate vertical assembly of the glass lens arrays is performed by anodic bonding. The latter ensures a high level of alignment both laterally and axially since no additional material is required. Thanks to polishing, the generated lens doublets are then as thin as several hundreds of microns and compatible with micro-opto-electro-systems (MOEMS) technologies since they are only made of glass and silicon. The generated optical module is then robust and provide improved optical performances. Indeed, theoretically, two stacked lenses with similar features and spherical profiles can be almost diffraction limited whereas a single lens characterized by the same numerical aperture than the doublet presents five times higher wavefront error. To demonstrate such assumption, we fabricated glass

  12. Influence of bone morphogenetic protein type IA receptor conditional knockout in lens on expression of bone morphogenetic protein 4 in lens

    Institute of Scientific and Technical Information of China (English)

    Qi; Zhao; Jiang-Yue; Zhao; Jin-Song; Zhang

    2015-01-01

    AIM: To investigate the influence of bone morphogenetic protein type IA receptor [BMPR-IA(ALK3)] conditional knockout in lens on expression of bone morphogenetic protein 4(BMP4) in lens during the development of the vertebrate eye.METHODS: Cre-positive mice were mated with Crenegative mice to generate 50% Cre-positive(conditional knockout, CKO) 4 embryos, 8 eyes and 50% Cre-negative offspring(wild type, WT) 4 embryos, 8 eyes. The embryos were fixed in 4% paraformaldehyde, embedded in paraffin, and sectioned to a thickness of 4 μm.Removal of paraffin wax and dehydrating for sections,and then the procedure of in situ hybridization was processed, BMP4 MK1784-m(BOSTER) was used, and observed the expression of BMP4 in the lens in experimental group and control group. We selected SPSS11.0 software for statistical analysis, P<0.05 showed that the difference was statistically significant.· RESULTS: Four embryos of each genotype were examined, totally we had 8 embryos, 16 eyes. We got the uniform outcomes in all the embryos. We found ALK3 was required during lens growing, but was not essential for the formation of lens. We observed that the expression of BMP4 in the lens was significantly reduced in all 8 ALK3 CKO lens, BMP4 expression was normal in all the 8 WT lens, P <0.01. This phenomenon became increasingly visible in accordance with embryo development. The most apparent alteration was present at stage E15.5.CONCLUSION: ALK3 is essential for lens growth. The influence of ALK3 on the expression of BMP4 is present during the development of mice lens.

  13. The Deep Lens Survey

    CERN Document Server

    Wittman, D; Dell'Antonio, I P; Becker, A C; Margoniner, V E; Cohen, J; Norman, D; Loomba, D; Squires, G; Wilson, G; Stubbs, C; Hennawi, J F; Spergel, D N; Boeshaar, P C; Clocchiatti, A; Hamuy, M; Bernstein, G; González, A; Guhathakurta, R; Hu, W; Seljak, U; Zaritsky, D

    2002-01-01

    The Deep Lens Survey (DLS) is a deep BVRz' imaging survey of seven 2x2 degree fields, with all data to be made public. The primary scientific driver is weak gravitational lensing, but the survey is also designed to enable a wide array of other astrophysical investigations. A unique feature of this survey is the search for transient phenomena. We subtract multiple exposures of a field, detect differences, classify, and release transients on the Web within about an hour of observation. Here we summarize the scientific goals of the DLS, field and filter selection, observing techniques and current status, data reduction, data products and release, and transient detections. Finally, we discuss some lessons which might apply to future large surveys such as LSST.

  14. A Fully Integrated RF-Powered Contact Lens With a Single Element Display.

    Science.gov (United States)

    Pandey, J; Yu-Te Liao; Lingley, Andrew; Mirjalili, R; Parviz, B; Otis, B

    2010-12-01

    We present progress toward a wirelessly-powered active contact lens comprised of a transparent polymer substrate, loop antenna, power harvesting IC, and micro-LED. The fully integrated radio power harvesting and power management system was fabricated in a 0.13 μm CMOS process with a total die area of 0.2 mm(2). It utilizes a small on-chip capacitor for energy storage to light up a micro-LED pixel. We have demonstrated wireless power transfer at 10 cm distance using the custom IC and on-lens antenna.

  15. Transferring Lens Prescriptions Between Lens-Design Programs

    Science.gov (United States)

    Stacy, John E.; Wooley, Laura; Carlin, Brian

    1989-01-01

    Optical Lens Prescription Data Formatter computer program enables user to transfer complicated lens prescriptions quickly and easily from one major optical-design program to another and back again. One can take advantage of inherent strength of either program. Programs are ACCOS V from Scientific Calculations, Inc., of Fishers, NY, and CODE V from Optical Research Associates of Pasadena, CA. VAX version written in FORTRAN.

  16. Micro Engineering

    DEFF Research Database (Denmark)

    Alting, Leo; Kimura, F.; Hansen, Hans Nørgaard

    2003-01-01

    The paper addresses the questions of how micro products are designed and how they are manufactured. Definitions of micro products and micro engineering are discussed and the presentation is aimed at describing typical issues, possibilities and tools regarding design of micro products. The implica......The paper addresses the questions of how micro products are designed and how they are manufactured. Definitions of micro products and micro engineering are discussed and the presentation is aimed at describing typical issues, possibilities and tools regarding design of micro products...

  17. Identification of origin of single aerosol particles using polycapillary X-ray lens

    Energy Technology Data Exchange (ETDEWEB)

    Sun Tianxi [Key Laboratory of Beam Technology and Materials Modification of Ministry of Education, Beijing Normal University, Beijing 100875 (China) and Institute of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875 (China) and Beijing Radiation Center, Beijing 100875 (China)], E-mail: stxbeijing@163.com; Liu Zhiguo; Zhu Guanghua; Liu Hui [Key Laboratory of Beam Technology and Materials Modification of Ministry of Education, Beijing Normal University, Beijing 100875 (China); Institute of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875 (China); Beijing Radiation Center, Beijing 100875 (China); Xu Qing [Institute of High Energy Physics, Chinese Academy of Science, Beijing 100039 (China); Li Yude; Wang Guangpu; Sun Hongbo; Luo Ping; Pan Qiuli; Ding Xunliang [The Key Laboratory of Beam Technology and Materials Modification of Ministry of Education, Beijing Normal University, Beijing 100875 (China); Institute of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875 (China); Beijing Radiation Center, Beijing 100875 (China)

    2009-01-15

    A micro X-ray fluorescence (Micro-XRF) spectrometer based on a polycapillary focusing X-ray lens (PFXRL) and a laboratory X-ray source was designed to carry out the XRF analysis of single aerosol particles. The minimum detection limit (MDL) of this Micro-XRF spectrometer was 9 ppm for the Fe-K{alpha}. The percentage of the particles of vehicle exhaust among aerosol particles was studied in Beijing, Chinese capital, during the test of odd-even driving restrictions for Beijing 2008 Olympics Games. This Micro-XRF spectrometer had potential applications in the analysis of single aerosol particles.

  18. Connexin hemichannels in the lens

    Directory of Open Access Journals (Sweden)

    Eric C Beyer

    2014-02-01

    Full Text Available The normal function and survival of cells in the avascular lens is facilitated by intercellular communication through an extensive network of gap junctions formed predominantly by three connexins (Cx43, Cx46, and Cx50. In expression systems, these connexins can all induce hemi-channel currents, but other lens proteins (e.g., pannexin1 can also induce similar currents. Hemichannel currents have been detected in isolated lens fiber cells. These hemichannels may make significant contributions to normal lens physiology and pathophysiology. Studies of some connexin mutants linked to congenital cataracts have implicated hemichannels with aberrant voltage-dependent gating or modulation by divalent cations in disease pathogenesis. Hemichannels may also contribute to age- and disease-related cataracts.

  19. 基于多线索混合词典的微博情绪识别%Emotion Recognition of Micro-blogs Based on a Hybrid Lexicon

    Institute of Scientific and Technical Information of China (English)

    潘明慧; 牛耘

    2014-01-01

    The proliferation of micro-blogs has created a popular digital platform where people are able to express emotions and share feelings. Analysis of emotions in micro-blogs would be potentially beneficial to companies and the society. In this paper,a lexicon-based approach is proposed to identify six emotions in micro-blog text,including joy,sadness,anger,fear,disgust and surprise. A lexicon of emoticons is built based on the mutual information method between emoticons and emotions. Combined with a traditional emotion lexicon in this approach,negation rules are made to process negations in emotion expression to analyze mirco-blog. The first corpus of Chinese micro-blogs manually annotated with the six emotions is built as the test set. The experimental results show that the traditional lexicon has a moderate accuracy and coverage in analysis of micro-blog text. The combination of the two lexicons greatly improves the accuracy and coverage.%微博等社交媒体为人们情绪表达提供了重要平台,分析微博的情绪倾向具有重要的商业价值和社会意义。文中提出了基于词典的规则方法识别微博所表达的喜、哀、怒、惧、恶、惊六种情绪。针对情绪表达的重要线索表情符利用互信息法生成了表情符词典,与传统情绪词典相结合,制定了针对否定用法的规则对微博进行分析。建立了第一个包含六种情绪的人工标注微博数据集。实验表明,传统的情绪词典虽然收录了大量词汇,但对于社交媒体文本分析的准确率和覆盖率都不高。表情符词典的应用显著地提高了微博情绪分析的精度和覆盖率。

  20. Gravitational lens surveys with LOFAR

    CERN Document Server

    Wucknitz, O

    2008-01-01

    Deep surveys planned as a Key Science Project of LOFAR provide completely new opportunities for gravitational lens searches. For the first time do large-scale surveys reach the resolution required for a direct selection of lens candidates using morphological criteria. We briefly describe the strategies that we will use to exploit this potential. The long baselines of an international E-LOFAR are essential for this project.

  1. Ascorbate in the ocular lens

    OpenAIRE

    Mody, Vino C. Jr

    2006-01-01

    Purpose: First, we intended to establish a method for sample preparation for measurement of ascorbate in whole rat and guinea pig lenses utilizing ultrafiltration and high performance liquid chromatography with ultraviolet radiation detection. Then, we aimed to investigate whether, in the albino rat, lens ascorbate concentration depends on solid dietary intake. Finally, we investigated if, in the pigmented guinea pig, lens ascorbate concentration may be elevated with drinkin...

  2. Phakic Intraocular lens- a review

    OpenAIRE

    Cruz, Francisco Miguel

    2015-01-01

    Introduction: Intraocular refractive procedures with the implantation of a Phakic Intraocular lens have become a safe efficient and predictable alternative for treating high ametropias when the use of corneal photoablative procedures is not possible. The implantation of Phakic intraocular lens preservs the accomodative function,is a reversable refractive procedure, with minimal induction of higher order aberrations compaed with corneal photoablative procedures. Methods: An analytical review o...

  3. Connections between connexins, calcium, and cataracts in the lens.

    Science.gov (United States)

    Gao, Junyuan; Sun, Xiurong; Martinez-Wittinghan, Francisco J; Gong, Xiaohua; White, Thomas W; Mathias, Richard T

    2004-10-01

    There is a good deal of evidence that the lens generates an internal micro circulatory system, which brings metabolites, like glucose, and antioxidants, like ascorbate, into the lens along the extracellular spaces between cells. Calcium also ought to be carried into the lens by this system. If so, the only path for Ca2+ to get out of the lens is to move down its electrochemical gradient into fiber cells, and then move by electrodiffusion from cell to cell through gap junctions to surface cells, where Ca-ATPase activity and Na/Ca exchange can transport it back into the aqueous or vitreous humors. The purpose of the present study was to test this calcium circulation hypothesis by studying calcium homeostasis in connexin (Cx46) knockout and (Cx46 for Cx50) knockin mouse lenses, which have different degrees of gap junction coupling. To measure intracellular calcium, FURA2 was injected into fiber cells, and the gradient in calcium concentration from center to surface was mapped in each type of lens. In wild-type lenses the coupling conductance of the mature fibers was approximately 0.5 S/cm2 of cell to cell contact, and the best fit to the calcium concentration data varied from 700 nM in the center to 300 nM at the surface. In the knockin lenses, the coupling conductance was approximately 1.0 S/cm2 and calcium varied from approximately 500 nM at the center to 300 nM at the surface. Thus, when the coupling conductance doubled, the concentration gradient halved, as predicted by the model. In knockout lenses, the coupling conductance was zero, hence the efflux path was knocked out and calcium accumulated to approximately 2 microM in central fibers. Knockout lenses also had a dense central cataract that extended from the center to about half the radius. Others have previously shown that this cataract involves activation of a calcium-dependent protease, Lp82. We can now expand on this finding to provide a hypothesis on each step that leads to cataract formation: knockout of

  4. A course in lens design

    CERN Document Server

    Velzel, Chris

    2014-01-01

    A Course in Lens Design is an instruction in the design of image-forming optical systems. It teaches how a satisfactory design can be obtained in a straightforward way. Theory is limited to a minimum, and used to support the practical design work. The book introduces geometrical optics, optical instruments and aberrations. It gives a description of the process of lens design and of the strategies used in this process. Half of its content is devoted to the design of sixteen types of lenses, described in detail from beginning to end. This book is different from most other books on lens design because it stresses the importance of the initial phases of the design process: (paraxial) lay-out and (thin-lens) pre-design. The argument for this change of accent is that in these phases much information can be obtained about the properties of the lens to be designed. This information can be used in later phases of the design. This makes A Course in Lens Design a useful self-study book, and a suitable basis for an intro...

  5. TU-E-201-02: Eye Lens Dosimetry From CT Perfusion Studies

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, D. [Toshiba America Medical Systems (United States)

    2015-06-15

    . These actions should be considered when they are consistent with the clinical task and patient anatomy. Learning Objectives: To become familiar with method of eye dose estimation for patient in specific situation of brain perfusion CT To become familiar with level of eye lens radiation doses in patients undergoing brain perfusion MDCT To understand methods for reducing eye lens dose to patient Jong Min Park, Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea Eye lens dosimetry in radiotherapy using contact lens-shaped applicator Dose calculation accuracy of commercial treatment planning systems is relatively low at shallow depths. Therefore, in-vivo measurements are often performed in the clinic to verify delivered doses to eye lens which are located at shallow depth. Current in-vivo dosimetry for eye lens during radiotherapy is generally performed with small in-vivo dosimeters on the surface of patient eyelid. Since this procedure potentially contains considerable uncertainty, a contact lens-shaped applicator made of acrylic (lens applicator) was developed for in-vivo measurements of eye lens dose during radiotherapy to reduce uncertainty. The lens applicator allows the insertion of commercially available metal oxide semiconductor field effect transistor (MOSFET) dosimeters. Computed tomography (CT) images of an anthropomorphic phantom with and without the lens applicator were acquired. A total of 20 VMAT plans were delivered to an anthropomorphic phantom and the doses with the lens applicator and the doses at the surface of the eyelid were measured using both micro and standard MOSFET dosimeters. The differences in measured dose at the surface of the eyelid from the calculated lens dose were acquired. The differences between the measured and the calculated doses at the lens applicator, as well as the differences between the measured and the calculated doses at the surface of the eyelid were acquired. The statistical significance of the

  6. TU-E-201-00: Eye Lens Dosimetry for Patients and Staff

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    . These actions should be considered when they are consistent with the clinical task and patient anatomy. Learning Objectives: To become familiar with method of eye dose estimation for patient in specific situation of brain perfusion CT To become familiar with level of eye lens radiation doses in patients undergoing brain perfusion MDCT To understand methods for reducing eye lens dose to patient Jong Min Park, Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea Eye lens dosimetry in radiotherapy using contact lens-shaped applicator Dose calculation accuracy of commercial treatment planning systems is relatively low at shallow depths. Therefore, in-vivo measurements are often performed in the clinic to verify delivered doses to eye lens which are located at shallow depth. Current in-vivo dosimetry for eye lens during radiotherapy is generally performed with small in-vivo dosimeters on the surface of patient eyelid. Since this procedure potentially contains considerable uncertainty, a contact lens-shaped applicator made of acrylic (lens applicator) was developed for in-vivo measurements of eye lens dose during radiotherapy to reduce uncertainty. The lens applicator allows the insertion of commercially available metal oxide semiconductor field effect transistor (MOSFET) dosimeters. Computed tomography (CT) images of an anthropomorphic phantom with and without the lens applicator were acquired. A total of 20 VMAT plans were delivered to an anthropomorphic phantom and the doses with the lens applicator and the doses at the surface of the eyelid were measured using both micro and standard MOSFET dosimeters. The differences in measured dose at the surface of the eyelid from the calculated lens dose were acquired. The differences between the measured and the calculated doses at the lens applicator, as well as the differences between the measured and the calculated doses at the surface of the eyelid were acquired. The statistical significance of the

  7. Micro Engineering

    DEFF Research Database (Denmark)

    Alting, Leo; Kimura, F.; Hansen, Hans Nørgaard

    2003-01-01

    The paper addresses the questions of how micro products are designed and how they are manufactured. Definitions of micro products and micro engineering are discussed and the presentation is aimed at describing typical issues, possibilities and tools regarding design of micro products. The implica...

  8. Intraocular camera for retinal prostheses: Refractive and diffractive lens systems

    Science.gov (United States)

    Hauer, Michelle Christine

    The focus of this thesis is on the design and analysis of refractive, diffractive, and hybrid refractive/diffractive lens systems for a miniaturized camera that can be surgically implanted in the crystalline lens sac and is designed to work in conjunction with current and future generation retinal prostheses. The development of such an intraocular camera (IOC) would eliminate the need for an external head-mounted or eyeglass-mounted camera. Placing the camera inside the eye would allow subjects to use their natural eye movements for foveation (attention) instead of more cumbersome head tracking, would notably aid in personal navigation and mobility, and would also be significantly more psychologically appealing from the standpoint of personal appearances. The capability for accommodation with no moving parts or feedback control is incorporated by employing camera designs that exhibit nearly infinite depth of field. Such an ultracompact optical imaging system requires a unique combination of refractive and diffractive optical elements and relaxed system constraints derived from human psychophysics. This configuration necessitates an extremely compact, short focal-length lens system with an f-number close to unity. Initially, these constraints appear highly aggressive from an optical design perspective. However, after careful analysis of the unique imaging requirements of a camera intended to work in conjunction with the relatively low pixellation levels of a retinal microstimulator array, it becomes clear that such a design is not only feasible, but could possibly be implemented with a single lens system.

  9. [Intraocular Pressure Sensor Based on a Contact Lens].

    Science.gov (United States)

    Guo, Xuhong; Pet, Weihua; Yao, Zhaolin; Chen, Yuanfang; Hu, Xiaohui; Chen, Hongda; Zhu, Jingyuan; Wu, Huijuan

    2016-02-01

    Intraocular pressure detection has a great significance for understanding the status of eye health, prevention and treatment of diseases such as glaucoma. Traditional intraocular pressure detection needs to be held in the hospital. It is not only time-consuming to doctors and patients, but also difficult to achieve 24 hour-continuous detection. Microminiaturization of the intraocular pressure sensor and wearing it as a contact lens, which is convenient, comfortable and noninvasive, can solve this problem because the soft contact lens with an embedded micro fabricated strain gauge allows the measurement of changes in corneal curvature to correlate to variations of intraocular pressure. We fabricated a strain gauge using micro-electron mechanical systems, and integrated with the contact lens made of polydimethylsiloxane (PDMS) using injection molding. The experimental results showed that the sensitivity was 100. 7 µV/µm. When attached to the corneal surface, the average sensitivity of sensor response of intraocular pressure can be 125.8 µV/mm Hg under the ideal condition.

  10. The 2010 IODC lens design problem: the green lens

    Science.gov (United States)

    Juergens, Richard C.

    2010-08-01

    The lens design problem for the 2010 IODC is to design a 100 mm focal length lens in which every optical surface has the same radius of curvature, positive or negative, or is plano. The lens is used monochromatically at 532 nm and is made of only Schott N-BK7 glass. The goal of the problem is to maximize the product of the semi-field of view and the entrance pupil diameter while holding the distortion to within +/-5% and the RMS wavefront error to <= 0.07 wave within the field of view. There were 37 entries from eight different countries. Four different commercial lens design programs were used, along with two custom, in-house programs. The number of lens elements in the entries ranged from 3 to 64. The overall length of the lenses varied from 105 mm to 3.6 km. The winning entry had an entrance pupil diameter of 81.3 mm and a semi-field of view of 43.5° for a merit function product of 3537.

  11. Formation flying for a Fresnel lens observatory mission

    CERN Document Server

    Krizmanic, J; Gehrels, N; Krizmanic, John; Skinner, Gerry; Gehrels, Neil

    2006-01-01

    The employment of a large area Phase Fresnel Lens (PFL) in a gamma-ray telescope offers the potential to image astrophysical phenomena with micro-arcsecond angular resolution. In order to assess the feasibility of this concept, two detailed studies have been conducted of formation flying missions in which a Fresnel lens capable of focussing gamma-rays and the associated detector are carried on two spacecraft separated by up to 10$^6$ km. These studies were performed at the NASA Goddard Space Flight Center Integrated Mission Design Center (IMDC) which developed spacecraft, orbital dynamics, and mission profiles. The results of the studies indicated that the missions are challenging but could be accomplished with technologies available currently or in the near term. The findings of the original studies have been updated taking account of recent advances in ion thruster propulsion technology.

  12. Design of Wind and Solar Energy Hybrid Micro Grid Intelligent Terminal%风光互补微电网智能测控终端的设计

    Institute of Scientific and Technical Information of China (English)

    吕继伟; 向驰; 付永长; 周振华; 宋春亮

    2012-01-01

    为了集中采集微网系统实时运行数据,并且对微网系统进行协调控制以及对蓄电池充放电进行有效管理,设计了微网智能测控终端。测控终端结构简单、运行可靠,硬件上采用高性能的ADSP—BF518数字信号处理芯片和高精度同步采样模数转换芯片AD7606,从而实现数据集中采集功能,并采用基于短期负荷预测的储能控制策略实现蓄电池管理。测控终端通过通信网络可以及时向监控中心上传数据,并能够接受中心下发遥控指令对微网系统进行控制。工程实践表明,该设计在微网实时监测与集中控制方面效果明显。%This paper proposes the intelligent terminal design just for measuring and sampling the real-time voltage and current data of micro grid, realization for coordinated control of micro grid and battery management. The terminal possesses the simple structure and reliable operation. The paper gives the use of high performance about ADSP - BFS18 and the measurement chip AD7606 on hardware design. The control strategy based on short-term load forecasting has been adopted in the energy storage and battery management system. The terminal can upload the sampled data and accept remote commands through the GPRS communication network. Engineering results show that the design is accurate and reliable in terms of micro grid measurement and control.

  13. Contact Lens Visual Rehabilitation in Keratoconus and Corneal Keratoplasty

    Directory of Open Access Journals (Sweden)

    Yelda Ozkurt

    2012-01-01

    Full Text Available Keratoconus is the most common corneal distrophy. It’s a noninflammatory progressive thinning process that leads to conical ectasia of the cornea, causing high myopia and astigmatism. Many treatment choices include spectacle correction and contact lens wear, collagen cross linking, intracorneal ring segments implantation and finally keratoplasty. Contact lenses are commonly used to reduce astigmatism and increase vision. There are various types of lenses are available. We reviewed soft contact lenses, rigid gas permeable contact lenses, piggyback contact lenses, hybrid contact lenses and scleral-semiscleral contact lenses in keratoconus management. The surgical option is keratoplasty, but even after sutur removal, high astigmatism may stil exists. Therefore, contact lens is an adequate treatment option to correct astigmatism after keratoplasty.

  14. Submicron hollow spot generation by solid immersion lens and structured illumination

    NARCIS (Netherlands)

    Kim, M.S.; Assafrao, A.C.; Scharf, T.; Wachters, A.J.H.; Pereira, S.F.; Urbach, H.P.; Brun, M.; Olivier, S.; Nicoletti, S.; Herzig, H.P.

    2012-01-01

    We report on the experimental and numerical demonstration of immersed submicron-size hollow focused spots, generated by structuring the polarization state of an incident light beam impinging on a micro-size solid immersion lens (μ-SIL) made of SiO2. Such structured focal spots are characterized by a

  15. Submicron hollow spot generation by solid immersion lens and structured illumination

    NARCIS (Netherlands)

    Kim, M.S.; Assafrao, A.C.; Scharf, T.; Wachters, A.J.H.; Pereira, S.F.; Urbach, H.P.; Brun, M.; Olivier, S.; Nicoletti, S.; Herzig, H.P.

    2012-01-01

    We report on the experimental and numerical demonstration of immersed submicron-size hollow focused spots, generated by structuring the polarization state of an incident light beam impinging on a micro-size solid immersion lens (μ-SIL) made of SiO2. Such structured focal spots are characterized by a

  16. Locked Nucleic Acid-Based In Situ Hybridization Reveals miR-7a as a Hypothalamus-Enriched MicroRNA with a Distinct Expression Pattern

    DEFF Research Database (Denmark)

    Herzer, S; Silahtaroglu, A; Meister, B

    2012-01-01

    MicroRNAs (miRNAs) are short (22 nucleotides) non-coding ribonucleic acid (RNA) molecules that post-transcriptionally repress expression of protein-coding genes by binding to 3'-untranslated regions of the target mRNAs. In order to identify miRNAs selectively expressed within the hypothalamus...... present in the hypothalamus, miR-7a, was the only miRNA found to be enriched in the hypothalamus, with low or no expression in other parts of the central nervous system (CNS). Within the hypothalamus, strong miR-7a expression was distinct and restricted to some hypothalamic nuclei and adjacent areas. mi......R-7a expression was particularly prominent in the subfornical organ, suprachiasmatic, paraventricular, periventricular, supraoptic, dorsomedial and arcuate nuclei. Identical expression patterns for miR-7a was seen in mouse and rat hypothalamus. By combining LNA-FISH with immunohistochemistry...

  17. Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleicacid probes and tyramide signal amplification

    DEFF Research Database (Denmark)

    Silahtaroglu, Asli N.; Nolting, Dorrit; Andersen, Lars Dyrskjøt

    2007-01-01

    RNAs in frozen tissue sections using fluorescence in situ hybridization (FISH). The method combines the unique miRNA recognition properties of locked nucleic acid (LNA)-modified oligonucleotide probes with FISH using the tyramide signal amplification (TSA) technology. Although both approaches have previously...... been shown to increase detection sensitivity in FISH, combining these techniques into one protocol significantly decreases the time needed for miRNA detection in cryosections, while simultaneously retaining high detection sensitivity. Starting with fixation of the tissue sections, this miRNA FISH...... protocol can be completed within approximately 6 h and allows miRNA detection in a wide variety of animal tissue cryosections as well as in human tumor biopsies at high cellular resolution....

  18. Cellular delivery of quantum dot-bound hybridization probe for detection of intracellular pre-microRNA using chitosan/poly(γ-glutamic acid complex as a carrier.

    Directory of Open Access Journals (Sweden)

    Yao Geng

    Full Text Available A quantum dot (QD-bound hybridization probe was designed for detection of intracellular pre-miRNA using chitosan (CS/poly(γ-glutamic acid (γ-PGA complex as a gene vector. The probe was prepared by assembling thiolated RNA to gold nanoparticle (Au NP via Au-S bond and then binding 3'-end amine of the RNA to the carboxy group capped on quantum dot surface. The QD-RNA-Au NP probe was assembled on the vector by mixing with aqueous γ-PGA solution and then CS solution to construct a gene delivery system for highly effective cellular uptake and delivery. After the probe was released from CS/γ-PGA complex to the cytoplasm by electrostatic repulsion at intracellular pH, it hybridized with pre-miRNA precursor as target. The formed product was then cleaved by RNase III Dicer, leading to the separation of QDs from Au NPs and fluorescence emission of QDs, which could be detected by confocal microscopic imaging to monitor the amount of the intracellular pre-miRNA precursor. The in vitro assays revealed that the QD-RNA-Au NP was a robust, sensitive and selective probe for quantitative detection of target pre-miRNA. Using MDA-MB231 and MCF-7 breast cancer cells as models, the relative amount of pre-miRNA let-7a could be successfully compared. Since the amount of miRNA is related to the progress and prognosis of cancer, this strategy could be expected to hold promising application potential in medical research and clinical diagnostics.

  19. Monolithic MACS micro resonators

    Science.gov (United States)

    Lehmann-Horn, J. A.; Jacquinot, J.-F.; Ginefri, J. C.; Bonhomme, C.; Sakellariou, D.

    2016-10-01

    Magic Angle Coil Spinning (MACS) aids improving the intrinsically low NMR sensitivity of heterogeneous microscopic samples. We report on the design and testing of a new type of monolithic 2D MACS resonators to overcome known limitations of conventional micro coils. The resonators' conductors were printed on dielectric substrate and tuned without utilizing lumped element capacitors. Self-resonance conditions have been computed by a hybrid FEM-MoM technique. Preliminary results reported here indicate robust mechanical stability, reduced eddy currents heating and negligible susceptibility effects. The gain in B1 /√{ P } is in agreement with the NMR sensitivity enhancement according to the principle of reciprocity. A sensitivity enhancement larger than 3 has been achieved in a monolithic micro resonator inside a standard 4 mm rotor at 500 MHz. These 2D resonators could offer higher performance micro-detection and ease of use of heterogeneous microscopic substances such as biomedical samples, microscopic specimens and thin film materials.

  20. Tinting of intraocular lens implants

    Energy Technology Data Exchange (ETDEWEB)

    Zigman, S.

    1982-06-01

    Intraocular lens (IOL) implants of polymethyl methacrylate (PMMA) lack an important yellow pigment useful as a filter in the visual process and in the protection of the retina from short-wavelength radiant energy. The ability to produce a yellow pigment in the PMMA used in IOL implants by exposure to near-ultraviolet (UV) light was tested. It was found that the highly cross-linked material in Copeland lens blanks was tinted slightly because of this exposure. The absorptive properties of lens blanks treated with near-UV light in this way approached that of the absorptive properties of human lenses. This finding shows that it is possible to alter IOL implants simply so as to induce a pale-yellow pigment in them to improve the visual process and to protect the retinas of IOL users.

  1. International rigid contact lens prescribing.

    Science.gov (United States)

    Efron, Nathan; Morgan, Philip B; Helland, Magne; Itoi, Motozumi; Jones, Deborah; Nichols, Jason J; van der Worp, Eef; Woods, Craig A

    2010-06-01

    Rigid lenses have been fitted less since the introduction of soft lenses nearly 40 years ago. Data that we have gathered from annual contact lens fitting surveys conducted in Australia, Canada, Japan, the Netherlands, Norway, the UK and the USA between 2000 and 2008 facilitate an accurate characterization of the pattern of the decline of rigid lens fitting during the first decade of this century. There is a trend for rigid lenses to be utilized primarily for refitting those patients who are already successful rigid lens wearers-most typically older females being refit with higher Dk materials. Rigid lenses are generally fitted on a full-time basis (four or more days of wear per week) without a planned replacement schedule. Orthokeratology is especially popular in the Netherlands, but is seldom prescribed in the other countries surveyed.

  2. The SNAP Strong Lens Survey

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, P.

    2005-01-03

    Basic considerations of lens detection and identification indicate that a wide field survey of the types planned for weak lensing and Type Ia SNe with SNAP are close to optimal for the optical detection of strong lenses. Such a ''piggy-back'' survey might be expected even pessimistically to provide a catalogue of a few thousand new strong lenses, with the numbers dominated by systems of faint blue galaxies lensed by foreground ellipticals. After sketching out our strategy for detecting and measuring these galaxy lenses using the SNAP images, we discuss some of the scientific applications of such a large sample of gravitational lenses: in particular we comment on the partition of information between lens structure, the source population properties and cosmology. Understanding this partitioning is key to assessing strong lens cosmography's value as a cosmological probe.

  3. Planar immersion lens with metasurfaces

    CERN Document Server

    Ho, John S; Tanabe, Yuji; Yeh, Alexander J; Fan, Shanhui; Poon, Ada S Y

    2015-01-01

    The solid immersion lens is a powerful optical tool that allows light entering material from air or vacuum to focus to a spot much smaller than the free-space wavelength. Conventionally, however, they rely on semispherical topographies and are non-planar and bulky, which limits their integration in many applications. Recently, there has been considerable interest in using planar structures, referred to as metasurfaces, to construct flat optical components for manipulating light in unusual ways. Here, we propose and demonstrate the concept of a planar immersion lens based on metasurfaces. The resulting planar device, when placed near an interface between air and dielectric material, can focus electromagnetic radiation incident from air to a spot in material smaller than the free-space wavelength. As an experimental demonstration, we fabricate an ultrathin and flexible microwave lens and further show that it achieves wireless energy transfer in material mimicking biological tissue.

  4. Algebraic Lens Distortion Model Estimation

    Directory of Open Access Journals (Sweden)

    Luis Alvarez

    2010-07-01

    Full Text Available A very important property of the usual pinhole model for camera projection is that 3D lines in the scene are projected to 2D lines. Unfortunately, wide-angle lenses (specially low-cost lenses may introduce a strong barrel distortion, which makes the usual pinhole model fail. Lens distortion models try to correct such distortion. We propose an algebraic approach to the estimation of the lens distortion parameters based on the rectification of lines in the image. Using the proposed method, the lens distortion parameters are obtained by minimizing a 4 total-degree polynomial in several variables. We perform numerical experiments using calibration patterns and real scenes to show the performance of the proposed method.

  5. Hybrid micro-grid energy optimization and sensitivity analysis of influencing factors%混合微电网能量优化配置及影响因素灵敏度分析

    Institute of Scientific and Technical Information of China (English)

    谭颖; 吕智林; 李苏川

    2015-01-01

    For the sake of reliability and economics of distributed generation ( DG) system power supply, a rational allocation of distributed power is needed. Aiming at the impact of PV and wind turbine output fluctuations on system, a standalone hybrid micro-grid economic model is proposed in consideration of the control strategy. By optimizing the objective function to determine the optimal capacity of the micro-power, the constraints of reliability of power supply and economics are ensured simultaneously. An independent micro-grid of Guangxi mountain area is selected as a case study to optimize the design. By using HOMER software for simulation, the rationality of the economic model is verified. Besides, based on the optimization results of different air pollution penalties prices, diesel prices, annual light intensity, average annual wind speeds and the cost variation of equipment investment, a sensitivity analysis which revolving around pollution , economics and reliability of power supply is carried on.%为了对分布式电源进行合理配置,以满足分布式发电( DG)系统的供电可靠性和经济性,针对光伏和风机出力波动对系统的影响,在考虑控制策略的前提下提出一种独立运行混合微电网经济模型。通过对目标函数的优化确定微电源的最优容量,以确保系统满足供电可靠性约束的同时保证其经济性。选取广西某山区一独立微电网为实例进行优化设计,应用HOMER软件对该系统进行仿真以验证经济模型的合理性,并对算例在不同空气污染惩罚、柴油价格、年均日照强度、年均风速以及设备投资成本变化等条件下的优化配置结果进行灵敏度分析,围绕系统的污染排放、经济性和供电可靠性进行灵敏度分析。

  6. Comprehending the Macro Through the Lens of the Micro

    Directory of Open Access Journals (Sweden)

    Lisa Zimmerman

    2016-02-01

    Full Text Available The South African Grade 4 learners had the lowest achievement mean of all participating education systems for the Progress in International Reading Literacy Study (PIRLS 2006. Further investigation was required to explore the potential reasons for the low performance. Although traditionally, secondary analyses of the data for international comparative studies of learner achievement have involved quantitative procedures, the mixed methods research design used for this study with emphasis placed on the qualitative phase was a unique departure from this methodological status quo. The aim was to explore schooling conditions and teaching practices for Grade 4 learners’ reading literacy development across the range of South African education contexts. In the first phase of the research, teacher and school survey data linked to a nationally representative learner sample (n = 14,299 for the PIRLS 2006 were used for description of Grade 4 teachers’ instruction practices and schooling conditions. This description took place on the basis of the reclassification of the teacher and school survey data according to class language profiles and average class performance as aligned to each of the achievement benchmarks of the PIRLS 2006 and further benchmarks created to describe the performance levels of the majority of South African learners. Thereafter, in the second phase, seven qualitative school and teacher case studies from each reclassification subsample were purposively selected to add illuminatory depth to the study. The sampling strategy allowed for scrutiny of cases with high PIRLS achievement profiles against cases with poor achievement profiles, and the comparisons afforded a far greater understanding of the problem. This article reflects on the methodological rationales, processes, and outcomes associated with this methodological choice.

  7. Panoramic lens designed with transformation optics

    Science.gov (United States)

    Wang, Huaping; Deng, Yangyang; Zheng, Bin; Li, Rujiang; Jiang, Yuyu; Dehdashti, Shahram; Xu, Zhiwei; Chen, Hongsheng

    2017-01-01

    The panoramic lens is a special kind of lens, which is applied to observe full view. In this letter, we theoretically present a panoramic lens (PL) using transformation optics method. The lens is designed with inhomogeneous and anisotropic constitutive parameters, which has the ability to gather light from all directions and confine light within the visual angle of observer. Simulation results validate our theoretical design.

  8. SimpLens: Interactive gravitational lensing simulator

    Science.gov (United States)

    Saha, Prasenjit; Williams, Liliya L. R.

    2016-06-01

    SimpLens illustrates some of the theoretical ideas important in gravitational lensing in an interactive way. After setting parameters for elliptical mass distribution and external mass, SimpLens displays the mass profile and source position, the lens potential and image locations, and indicate the image magnifications and contours of virtual light-travel time. A lens profile can be made shallower or steeper with little change in the image positions and with only total magnification affected.

  9. A comparative study on low cycle fatigue behaviour of nano and micro Al2O3 reinforced AA2014 particulate hybrid composites

    Science.gov (United States)

    Senthilkumar, R.; Arunkumar, N.; Manzoor Hussian, M.

    Aluminium based metal matrix composites have drawn more attraction due to their improved properties in structural applications for the past two decades. The fatigue behaviour of composite materials needs to be studied for their structural applications. In this work, powder metallurgy based aluminium (AA2014) alloy reinforced with micro and nano-sized alumina particles were fabricated and consolidated with the hot extrusion process. The evaluation of mechanical properties in the extruded composite was carried out. This composite was subjected to low cycle fatigue test with a constant strain rate. Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM) images were used to evaluate the fatigue behaviour of aluminium-nano composite samples. Enhanced mechanical properties were exhibited by the nano alumina reinforced aluminium composites, when compared to the micron sized alumina reinforced composites. The failure cycle is observed to be higher for the nano alumina reinforced composites when compared with micron sized alumina composites due to a lower order of induced plastic strain.

  10. A comparative study on low cycle fatigue behaviour of nano and micro Al2O3 reinforced AA2014 particulate hybrid composites

    Directory of Open Access Journals (Sweden)

    R. Senthilkumar

    2015-01-01

    Full Text Available Aluminium based metal matrix composites have drawn more attraction due to their improved properties in structural applications for the past two decades. The fatigue behaviour of composite materials needs to be studied for their structural applications. In this work, powder metallurgy based aluminium (AA2014 alloy reinforced with micro and nano-sized alumina particles were fabricated and consolidated with the hot extrusion process. The evaluation of mechanical properties in the extruded composite was carried out. This composite was subjected to low cycle fatigue test with a constant strain rate. Scanning Electron Microscope (SEM and Transmission Electron Microscope (TEM images were used to evaluate the fatigue behaviour of aluminium-nano composite samples. Enhanced mechanical properties were exhibited by the nano alumina reinforced aluminium composites, when compared to the micron sized alumina reinforced composites. The failure cycle is observed to be higher for the nano alumina reinforced composites when compared with micron sized alumina composites due to a lower order of induced plastic strain.

  11. Subtractive hybridization-mediated analysis of genes and in silico prediction of associated microRNAs under waterlogged conditions in sugarcane (Saccharum spp.).

    Science.gov (United States)

    Khan, Mohammad Suhail; Khraiwesh, Basel; Pugalenthi, Ganesan; Gupta, Ram Sagar; Singh, Jyotsnendra; Duttamajumder, Sanjoy Kumar; Kapur, Raman

    2014-01-01

    Sugarcane is an important tropical cash crop meeting 75% of world sugar demand and it is fast becoming an energy crop for the production of bio-fuel ethanol. A considerable area under sugarcane is prone to waterlogging which adversely affects both cane productivity and quality. In an effort to elucidate the genes underlying plant responses to waterlogging, a subtractive cDNA library was prepared from leaf tissue. cDNA clones were sequenced and annotated for their putative functions. Major groups of ESTs were related to stress (15%), catalytic activity (13%), cell growth (10%) and transport related proteins (6%). A few stress-related genes were identified, including senescence-associated protein, dehydration-responsive family protein, and heat shock cognate 70 kDa protein. A bioinformatics search was carried out to discover novel microRNAs (miRNAs) that can be regulated in sugarcane plants subjected to waterlogging stress. Taking advantage of the presence of miRNA precursors in the related sorghum genome, seven candidate mature miRNAs were identified in sugarcane. The application of subtraction technology allowed the identification of differentially expressed sequences and novel miRNAs in sugarcane under waterlogging stress. The comparative global transcript profiling in sugarcane plants undertaken in this study suggests that proteins associated with stress response, signal transduction, metabolic activity and ion transport play important role in conferring waterlogging tolerance in sugarcane.

  12. Subtractive hybridization-mediated analysis of genes and in silico prediction of associated microRNAs under waterlogged conditions in sugarcane (Saccharum spp.

    Directory of Open Access Journals (Sweden)

    Mohammad Suhail Khan

    2014-01-01

    Full Text Available Sugarcane is an important tropical cash crop meeting 75% of world sugar demand and it is fast becoming an energy crop for the production of bio-fuel ethanol. A considerable area under sugarcane is prone to waterlogging which adversely affects both cane productivity and quality. In an effort to elucidate the genes underlying plant responses to waterlogging, a subtractive cDNA library was prepared from leaf tissue. cDNA clones were sequenced and annotated for their putative functions. Major groups of ESTs were related to stress (15%, catalytic activity (13%, cell growth (10% and transport related proteins (6%. A few stress-related genes were identified, including senescence-associated protein, dehydration-responsive family protein, and heat shock cognate 70 kDa protein. A bioinformatics search was carried out to discover novel microRNAs (miRNAs that can be regulated in sugarcane plants subjected to waterlogging stress. Taking advantage of the presence of miRNA precursors in the related sorghum genome, seven candidate mature miRNAs were identified in sugarcane. The application of subtraction technology allowed the identification of differentially expressed sequences and novel miRNAs in sugarcane under waterlogging stress. The comparative global transcript profiling in sugarcane plants undertaken in this study suggests that proteins associated with stress response, signal transduction, metabolic activity and ion transport play important role in conferring waterlogging tolerance in sugarcane.

  13. Subtractive hybridization-mediated analysis of genes and in silico prediction of associated microRNAs under waterlogged conditions in sugarcane (Saccharum spp.)

    KAUST Repository

    Khan, Mohammad Suhail

    2014-06-09

    Sugarcane is an important tropical cash crop meeting 75% of world sugar demand and it is fast becoming an energy crop for the production of bio-fuel ethanol. A considerable area under sugarcane is prone to waterlogging which adversely affects both cane productivity and quality. In an effort to elucidate the genes underlying plant responses to waterlogging, a subtractive cDNA library was prepared from leaf tissue. cDNA clones were sequenced and annotated for their putative functions. Major groups of ESTs were related to stress (15%), catalytic activity (13%), cell growth (10%) and transport related proteins (6%). A few stress-related genes were identified, including senescence-associated protein, dehydration-responsive family protein, and heat shock cognate 70. kDa protein. A bioinformatics search was carried out to discover novel microRNAs (miRNAs) that can be regulated in sugarcane plants subjected to waterlogging stress. Taking advantage of the presence of miRNA precursors in the related sorghum genome, seven candidate mature miRNAs were identified in sugarcane. The application of subtraction technology allowed the identification of differentially expressed sequences and novel miRNAs in sugarcane under waterlogging stress. The comparative global transcript profiling in sugarcane plants undertaken in this study suggests that proteins associated with stress response, signal transduction, metabolic activity and ion transport play important role in conferring waterlogging tolerance in sugarcane. © 2014 The Authors.

  14. Micro Vision

    OpenAIRE

    Ohba, Kohtaro; OHARA, Kenichi

    2007-01-01

    In the field of the micro vision, there are few researches compared with macro environment. However, applying to the study result for macro computer vision technique, you can measure and observe the micro environment. Moreover, based on the effects of micro environment, it is possible to discovery the new theories and new techniques.

  15. Evolution of a hybrid micro-macro entangled state of the qubit-oscillator system via the generalized rotating wave approximation

    Science.gov (United States)

    Chakrabarti, R.; Yogesh, V.

    2016-04-01

    We study the evolution of the hybrid entangled states in a bipartite (ultra) strongly coupled qubit-oscillator system. Using the generalized rotating wave approximation the reduced density matrices of the qubit and the oscillator are obtained. The reduced density matrix of the oscillator yields the phase space quasi probability distributions such as the diagonal P-representation, the Wigner W-distribution and the Husimi Q-function. In the strong coupling regime the Q-function evolves to uniformly separated macroscopically distinct Gaussian peaks representing ‘kitten’ states at certain specified times that depend on multiple time scales present in the interacting system. The ultrastrong coupling strength of the interaction triggers appearance of a large number of modes that quickly develop a randomization of their phase relationships. A stochastic averaging of the dynamical quantities sets in, and leads to the decoherence of the system. The delocalization in the phase space of the oscillator is studied by using the Wehrl entropy. The negativity of the W-distribution reflects the departure of the oscillator from the classical states, and allows us to study the underlying differences between various information-theoretic measures such as the Wehrl entropy and the Wigner entropy. Other features of nonclassicality such as the existence of the squeezed states and appearance of negative values of the Mandel parameter are realized during the course of evolution of the bipartite system. In the parametric regime studied here these properties do not survive in the time-averaged limit.

  16. Hybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivo

    KAUST Repository

    Deng, Lin

    2016-02-25

    Premature drug release is a common drawback in stimuli responsive drug delivery systems (DDS) especially if it depends on internal triggers, that are hard to control, or a single external stimulus, that can only have one function. Thus, many DDS systems were reported combining different triggers, however limited success has been established in fine-tuning the release process mainly due to the poor bioavailability and complexity of the reported designs. This paper reports the design of a hybrid microcapsule (h-MC) by a simple layer-by-layer technique comprising polysaccharides (Alg, Chi, HA), iron oxide, and graphene oxide. Electrostatic assembly of the oppositely charged polysaccharides and graphene sheets provided a robust structure to load drugs through pH control. The polysaccharides component ensured high biocompatibility, bioavailability, and tumor cells targeting. Magnetic field and near infrared laser triggerable Fe3O4@GO component provided dual high energy and high penetration hyperthermia therapy. On-demand drug release from h-MC can be achieved by synchronizing these external triggers, making it highly controllable. The synergistic effect of hyperthermia and chemotherapy was successfully confirmed in vitro and in vivo.

  17. In vivo human crystalline lens topography.

    Science.gov (United States)

    Ortiz, Sergio; Pérez-Merino, Pablo; Gambra, Enrique; de Castro, Alberto; Marcos, Susana

    2012-10-01

    Custom high-resolution high-speed anterior segment spectral domain optical coherence tomography (OCT) was used to characterize three-dimensionally (3-D) the human crystalline lens in vivo. The system was provided with custom algorithms for denoising and segmentation of the images, as well as for fan (scanning) and optical (refraction) distortion correction, to provide fully quantitative images of the anterior and posterior crystalline lens surfaces. The method was tested on an artificial eye with known surfaces geometry and on a human lens in vitro, and demonstrated on three human lenses in vivo. Not correcting for distortion overestimated the anterior lens radius by 25% and the posterior lens radius by more than 65%. In vivo lens surfaces were fitted by biconicoids and Zernike polynomials after distortion correction. The anterior lens radii of curvature ranged from 10.27 to 14.14 mm, and the posterior lens radii of curvature ranged from 6.12 to 7.54 mm. Surface asphericities ranged from -0.04 to -1.96. The lens surfaces were well fitted by quadrics (with variation smaller than 2%, for 5-mm pupils), with low amounts of high order terms. Surface lens astigmatism was significant, with the anterior lens typically showing horizontal astigmatism ([Formula: see text] ranging from -11 to -1 µm) and the posterior lens showing vertical astigmatism ([Formula: see text] ranging from 6 to 10 µm).

  18. 21 CFR 886.3600 - Intraocular lens.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Intraocular lens. 886.3600 Section 886.3600 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES OPHTHALMIC DEVICES Prosthetic Devices § 886.3600 Intraocular lens. (a) Identification. An intraocular lens is a device made of materials...

  19. Wafer integrated micro-scale concentrating photovoltaics

    Science.gov (United States)

    Gu, Tian; Li, Duanhui; Li, Lan; Jared, Bradley; Keeler, Gordon; Miller, Bill; Sweatt, William; Paap, Scott; Saavedra, Michael; Das, Ujjwal; Hegedus, Steve; Tauke-Pedretti, Anna; Hu, Juejun

    2017-09-01

    Recent development of a novel micro-scale PV/CPV technology is presented. The Wafer Integrated Micro-scale PV approach (WPV) seamlessly integrates multijunction micro-cells with a multi-functional silicon platform that provides optical micro-concentration, hybrid photovoltaic, and mechanical micro-assembly. The wafer-embedded micro-concentrating elements is shown to considerably improve the concentration-acceptance-angle product, potentially leading to dramatically reduced module materials and fabrication costs, sufficient angular tolerance for low-cost trackers, and an ultra-compact optical architecture, which makes the WPV module compatible with commercial flat panel infrastructures. The PV/CPV hybrid architecture further allows the collection of both direct and diffuse sunlight, thus extending the geographic and market domains for cost-effective PV system deployment. The WPV approach can potentially benefits from both the high performance of multijunction cells and the low cost of flat plate Si PV systems.

  20. Professoren og Ålen

    DEFF Research Database (Denmark)

    Poulsen, Bo

    2016-01-01

    Biolog og havforsker Johannes Schmidt regnes for at være Danmarks mest betydningsfulde havforsker gennem tiderne. Hans mange forskningsbaserede jordomsejlinger bragte ham til eksotiske egne og til opdagelsen af adskillige nye dyrearter. Dog blev særligt ålen og dens gydepladser et hovedfokus...

  1. Professoren og Ålen

    DEFF Research Database (Denmark)

    Poulsen, Bo

    2016-01-01

    Biolog og havforsker Johannes Schmidt regnes for at være Danmarks mest betydningsfulde havforsker gennem tiderne. Hans mange forskningsbaserede jordomsejlinger bragte ham til eksotiske egne og til opdagelsen af adskillige nye dyrearter. Dog blev særligt ålen og dens gydepladser et hovedfokus for ...

  2. The Ultrawideband Leaky Lens Antenna

    NARCIS (Netherlands)

    Bruni, S.; Neto, A.; Marliani, F.

    2007-01-01

    A novel directive and nondispersive antenna is presented: the ultrawideband (UWB) leaky lens. It is based on the broad band Cherenkov radiation occurring at a slot printed between different infinite homogeneous dielectrics. The first part of the paper presents the antenna concept and the UWB design.

  3. Rapid fabrication of miniature lens arrays by four-axis single point diamond machining.

    Science.gov (United States)

    McCall, Brian; Tkaczyk, Tomasz S

    2013-02-11

    A novel method for fabricating lens arrays and other non-rotationally symmetric free-form optics is presented. This is a diamond machining technique using 4 controlled axes of motion - X, Y, Z, and C. As in 3-axis diamond micro-milling, a diamond ball endmill is mounted to the work spindle of a 4-axis ultra-precision computer numerical control (CNC) machine. Unlike 3-axis micro-milling, the C-axis is used to hold the cutting edge of the tool in contact with the lens surface for the entire cut. This allows the feed rates to be doubled compared to the current state of the art of micro-milling while producing an optically smooth surface with very low surface form error and exceptionally low radius error.

  4. Formaldehyde vapor produced from hexamethylenetetramine and pesticide: Simultaneous monitoring of formaldehyde and ozone in chamber experiments by flow-based hybrid micro-gas analyzer.

    Science.gov (United States)

    Yanaga, Akira; Hozumi, Naruto; Ohira, Shin-Ichi; Hasegawa, Asako; Toda, Kei

    2016-02-01

    Simultaneous analysis of HCHO and O3 was performed by the developed flow analysis system to prove that HCHO vapor is produced from solid pesticide in the presence of O3. HCHO is produced in many ways, including as primary emissions from fuel combustion and in secondary production from anthropogenic and biogenic volatile organic compounds by photochemical reactions. In this work, HCHO production from pesticides was investigated for the first time. Commonly pesticide contains surfactant such as hexamethylenetetramine (HMT), which is a heterocyclic compound formed from six molecules of HCHO and four molecules of NH3. HMT can react with gaseous oxidants such as ozone (O3) to produce HCHO. In the present study, a flow analysis system was developed for simultaneous analysis of HCHO and O3, and this system was used to determine if solid pesticides produced HCHO vapor in the presence of O3. HMT or the pesticide jimandaisen, which contains mancozeb as the active ingradient and HMT as a stabilizer was placed at the bottom of a 20-L stainless steel chamber. Air in the chamber was monitored using the developed flow system. Analyte gases were collected into an absorbing solution by a honeycomb-patterned microchannel scrubber that was previously developed for a micro gas analysis system (μGAS). Subsequently, indigotrisulfonate, a blue dye, was added to the absorbing solution to detect O3, which discolored the solution. HCHO was detected after mixing with the Hantzsch reaction reagent. Both gases could be detected at concentrations ranging from parts per billion by volume (ppbv) to 1000 ppbv with good linearity. Both HMT and jimandaisen emitted large amount of HCHO in the presence of O3.

  5. Multifocal contact lens myopia control.

    Science.gov (United States)

    Walline, Jeffrey J; Greiner, Katie L; McVey, M Elizabeth; Jones-Jordan, Lisa A

    2013-11-01

    Previous studies on soft multifocal contact lens myopia control published in the peer-reviewed literature reported findings of noncommercial contact lenses worn for 1 year or less. This study sought to determine the progression of myopia and axial elongation of children fitted with commercially available distance center soft multifocal contact lenses for 2 years. Eight- to eleven-year-old children with -1.00 D to -6.00 D spherical component and less than 1.00 D astigmatism were fitted with soft multifocal contact lenses with a +2.00 D add (Proclear Multifocal "D"; CooperVision, Fairport, NY). They were age- and gender-matched to participants from a previous study who were fitted with single-vision contact lenses (1 Day Acuvue; Vistakon, Jacksonville, FL). A-scan ultrasound and cycloplegic autorefraction were performed at baseline, after 1 year, and after 2 years. Multilevel modeling was used to compare the rate of change of myopia and axial length between single-vision and soft multifocal contact lens wearers. Forty participants were fitted with soft multifocal contact lenses, and 13 did not contribute complete data (5 contributed 1 year of data). The adjusted mean ± standard error spherical equivalent progression of myopia at 2 years was -1.03 ± 0.06 D for the single-vision contact lens wearers and -0.51 ± 0.06 for the soft multifocal contact lens wearers (p < 0.0001). The adjusted mean axial elongation was 0.41 ± 0.03 and 0.29 ± 0.03 for the single-vision and soft multifocal contact lens wearers, respectively (p < 0.0016). Soft multifocal contact lens wear resulted in a 50% reduction in the progression of myopia and a 29% reduction in axial elongation during the 2-year treatment period compared to a historical control group. Results from this and other investigations indicate a need for a long-term randomized clinical trial to investigate the potential for soft multifocal contact lens myopia control.

  6. Micro-Based Genlocking Systems.

    Science.gov (United States)

    Hurly, Paul

    1986-01-01

    Presents a selective survey of micro-based genlocking systems currently on the market including those systems with open and closed architecture; examines the number and diversity of uses for this hybrid medium, which synchronizes video signals with computer-generated text and graphics; and discusses the role of cause and effect in innovation.

  7. Lens stem cells may reside outside the lens capsule: an hypothesis

    Directory of Open Access Journals (Sweden)

    Meyer Rita A

    2007-06-01

    Full Text Available Abstract In this paper, we consider the ocular lens in the context of contemporary developments in biological ideas. We attempt to reconcile lens biology with stem cell concepts and a dearth of lens tumors. Historically, the lens has been viewed as a closed system, in which cells at the periphery of the lens epithelium differentiate into fiber cells. Theoretical considerations led us to question whether the intracapsular lens is indeed self-contained. Since stem cells generate tumors and the lens does not naturally develop tumors, we reasoned that lens stem cells may not be present within the capsule. We hypothesize that lens stem cells reside outside the lens capsule, in the nearby ciliary body. Our ideas challenge the existing lens biology paradigm. We begin our discussion with lens background information, in order to describe our lens stem cell hypothesis in the context of published data. Then we present the ciliary body as a possible source for lens stem cells, and conclude by comparing the ocular lens with the corneal epithelium.

  8. Modern lens antennas for communications engineering

    CERN Document Server

    Thornton, John

    2012-01-01

    The aim of this book is to present the modern design principles and analysis of lens antennas. It gives graduates and RF/Microwave professionals the design insights in order to make full use of lens antennas.  Why do we want to write a book in lens antennas? Because this topic has not been thoroughly publicized, its importance is underestimated. As antennas play a key role in communication systems, recent development in wireless communications would indeed benefit from the characteristics of lens antennas: low profile, and low cost etc.  The major advantages of lens antennas are na

  9. Conjunctival impression cytology in contact lens wearers.

    Directory of Open Access Journals (Sweden)

    Simon Priya

    2002-01-01

    Full Text Available PURPOSE: To evaluate the cytological changes in conjunctiva following regular contact lens wear and to determine the correlation, if any, between severity of cytological alteration and symptoms related to contact lens wear. METHODS: One hundred eyes (50 normal asymptomatic subjects who served as a control group were studied by conjunctival impression cytology (CIC. These subjects were fitted with rigid gas permeable (RGP or soft contact lenses and were followed up at the end of 3 and 6 months. At each follow-up visit the CIC was repeated. A filter paper with the impression specimen was stained with periodic acid schiff (PAS and haematoxylin stain to study goblet cell loss. Papanicolaou stain was done to study squamous metaplasia. The cytological changes were graded using the system described by Natadisastra et al. RESULTS: Severity of cytological changes increased with the duration of contact lens wear (P = 0.00001. At the end of 6 months, 60% of symptomatic eyes wearing soft contact lens and RGP lens showed abnormal CIC changes. None of the asymptomatic RGP contact lens wearing eyes showed abnormal CIC changes whereas 33.4% of the asymptomatic soft contact lens wearing eyes showed abnormal CIC changes (P = 0.033. Epithelial changes occurred within 3-6 months of contact lens fitting. CONCLUSION: Severity of cytological changes increased with duration of lens wear (P = 0.00001. Prevalence and severity of cytological alteration is more in symptomatic contact lens wearers. Soft contact lens wearers although asymptomatic showed severe CIC changes.

  10. Lens-free imaging of magnetic particles in DNA assays.

    Science.gov (United States)

    Colle, Frederik; Vercruysse, Dries; Peeters, Sara; Liu, Chengxun; Stakenborg, Tim; Lagae, Liesbet; Del-Favero, Jurgen

    2013-11-01

    We present a novel opto-magnetic system for the fast and sensitive detection of nucleic acids. The system is based on a lens-free imaging approach resulting in a compact and cheap optical readout of surface hybridized DNA fragments. In our system magnetic particles are attracted towards the detection surface thereby completing the labeling step in less than 1 min. An optimized surface functionalization combined with magnetic manipulation was used to remove all nonspecifically bound magnetic particles from the detection surface. A lens-free image of the specifically bound magnetic particles on the detection surface was recorded by a CMOS imager. This recorded interference pattern was reconstructed in software, to represent the particle image at the focal distance, using little computational power. As a result we were able to detect DNA concentrations down to 10 pM with single particle sensitivity. The possibility of integrated sample preparation by manipulation of magnetic particles, combined with the cheap and highly compact lens-free detection makes our system an ideal candidate for point-of-care diagnostic applications.

  11. Study on Titanium Nitride Film Modified for Intraocular Lens

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Objective:To study the characteristics of the intraocular lens using ion beam sputtering depositing titanium nitride thin film on the intraocular lens(IOLs).Methods:To deposite titanium nitride thin film on the top of intraocular lens by ion beam sputtering depositing.We analyzed the surface morphology of intraocular lens through SEM and AFM.We detected intraocular lens resolution through the measurement of intraocular lens.Biocompatibility of intraocular lens is preliminary evaluated in this test.Results:T...

  12. Chalcogenide material strengthening through the lens molding process

    Science.gov (United States)

    Nelson, J.; Scordato, M.; Lucas, Pierre; Coleman, Garrett J.

    2016-05-01

    The demand for infrared transmitting materials has grown steadily for several decades as markets realize new applications for longer wavelength sensing and imaging. With this growth has come the demand for new and challenging material requirements that cannot be satisfied with crystalline products alone. Chalcogenide materials, with their unique physical, thermal, and optical properties, have found acceptance by designers and fabricators to meet these demands. No material is perfect in every regard, and chalcogenides are no exception. A cause for concern has been the relatively low fracture toughness and the propensity of the bulk material to fracture. This condition is amplified when traditional subtractive manufacturing processes are employed. This form of processing leaves behind micro fractures and sub surface damage, which act as propagation points for both local and catastrophic failure of the material. Precision lens molding is not a subtractive process, and as a result, micro fractures and sub surface damage are not created. This results in a stronger component than one produced by traditional methods. New processing methods have also been identified that result in an even stronger surface that is more resistant to breakage, without the need for post processing techniques that may compromise surface integrity. This paper will discuss results achieved in the process of lens molding development at Edmund Optics that result in measurably stronger chalcogenide components. Various metrics will be examined and data will be presented that quantifies component strength for different manufacturing processes.

  13. Highly stretchable piezoelectric-pyroelectric hybrid nanogenerator.

    Science.gov (United States)

    Lee, Ju-Hyuck; Lee, Keun Young; Gupta, Manoj Kumar; Kim, Tae Yun; Lee, Dae-Yeong; Oh, Junho; Ryu, Changkook; Yoo, Won Jong; Kang, Chong-Yun; Yoon, Seok-Jin; Yoo, Ji-Beom; Kim, Sang-Woo

    2014-02-01

    A highly stretchable hybrid nanogenerator has been developed using a micro-patterned piezoelectric polymer P(VDF-TrFE), PDMS-CNT composite, and graphene nanosheets. Mechanical and thermal energies are simultaneously harvested from a single cell of the device. The hybrid nanogenerator exhibits high robustness behavior even after 30% stretching and generates very stable piezoelectric and pyroelectric power outputs due to micro-pattern designing. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Lens Coupled Quantum Cascade Laser

    Science.gov (United States)

    Hu, Qing (Inventor); Lee, Alan Wei Min (Inventor)

    2013-01-01

    Terahertz quantum cascade (QC) devices are disclosed that can operate, e.g., in a range of about 1 THz to about 10 THz. In some embodiments, QC lasers are disclosed in which an optical element (e.g., a lens) is coupled to an output facet of the laser's active region to enhance coupling of the lasing radiation from the active region to an external environment. In other embodiments, terahertz amplifier and tunable terahertz QC lasers are disclosed.

  15. Fresnel Lens with Embedded Vortices

    Directory of Open Access Journals (Sweden)

    Sunil Vyas

    2012-01-01

    Full Text Available Vortices of different charges are embedded in a wavefront that has quadratic phase variation, and the intensity distribution near the focal plane is studied. This method may be useful in realizing complicated beam profiles. We have experimentally demonstrated the generation of vortex arrays having integer as well as fractional topological charges that produce different intensity profiles at the focal plane. The phase variation realized on a spatial light modulator (SLM acts as a Fresnel lens with embedded vortices.

  16. Contact lens wear is intrinsically inflammatory.

    Science.gov (United States)

    Efron, Nathan

    2017-01-01

    Eye-care practitioners typically associate ocular inflammation during contact lens wear with serious complications such as microbial keratitis; however, more subtle mechanisms may be at play. This paper tests the notion that contact lens wear is intrinsically inflammatory by exploring whether uncomplicated contact lens wear meets the classical, clinical definition of inflammation - rubor (redness), calor (heat), tumor (swelling), dolor (pain) and functio laesa (loss of function) - as well as the contemporary, sub-clinical definition of inflammation (cellular and biochemical reactions). It is demonstrated that all of these clinical and sub-clinical criteria are met with hydrogel lens wear and most are met with silicone hydrogel lens wear, indicating that uncomplicated contact lens wear is intrinsically inflammatory. Consideration of both traditional and contemporary thinking about the role of inflammation in the human body leads to the perhaps surprising conclusion that the chronic, low grade, sub-clinical inflammatory status of the anterior eye during contact lens wear, which may be termed 'para-inflammation', is a positive, protective phenomenon, whereby up-regulation of the immune system, in a non-damaging way, maintains the eye in a state of 'heightened alert', ready to ward off any extrinsic noxious challenge. Characterisation of this inflammatory status may lead to the development of lens engineering or pharmacological strategies to modulate contact lens-induced inflammation, so as to render lens wear more safe and comfortable. © 2016 Optometry Australia.

  17. Hybrid Baryons

    CERN Document Server

    Page, P R

    2003-01-01

    We review the status of hybrid baryons. The only known way to study hybrids rigorously is via excited adiabatic potentials. Hybrids can be modelled by both the bag and flux-tube models. The low-lying hybrid baryon is N 1/2^+ with a mass of 1.5-1.8 GeV. Hybrid baryons can be produced in the glue-rich processes of diffractive gamma N and pi N production, Psi decays and p pbar annihilation.

  18. Freeform lens collimating spectrum-folded Hadamard transform near-infrared spectrometer

    Science.gov (United States)

    Wang, Xiaoduo; Liu, Hua; Juschkin, Larissa; Li, Yunpeng; Xu, Jialin; Quan, Xiangqian; Lu, Zhenwu

    2016-12-01

    A novel Hadamard transform spectrometer collimated by a freeform lens has been designed, which doubles the working spectral range while the spectral resolution is maintained. The freeform lens is designed to redistribute the broadband spectra of the source from 800 nm to 2400 nm into two collimated beams with different wavelengths and different tilting angles, to achieve the folding of spectra on the digital micro-mirror devices (DMD). It is constructed by solving two partial differential equations. The grating diffraction efficiency of the two split beams are more uniform and higher compared with the traditional method. The simulation results show that the bandwidth of the spectrometer is doubled and the spectral resolution is better than 10 nm. The optical system becomes more compact, and the energy efficiency is improved by 11.98% by folding the spectra with one freeform lens and one grating.

  19. A split-electrode for clearing scattered electrons in the RHIC e-lens

    Energy Technology Data Exchange (ETDEWEB)

    Gu X.; Pikin, A.; Thieberger, P.; Fischer, W.; Hock, J.; Hamdi, K.; Gassner,D.; Luo, Y.; Montag, C.; Okamura, M.

    2012-05-20

    We are designing two electron lenses that will be installed at RHIC IR10 to compensate for the head-on beam-beam effect. To clear accumulated scattered electrons from 100 GeV proton-electron head-on collisions in the e-lens, a clearing split electrode may be constructed. The feasibility of this proposed electrode was demonstrated via the CST Particle Studio and Opera program simulations. By splitting one of the drift tubes in the e-lens and applying {approx} 380 V across the two parts, the scattered electrons can be cleared out within several hundred micro-seconds. At the same time we can restrict the unwanted shift of the primary electron-beam that already passed the 2-m interaction region in e-lens, to less than 15um.

  20. Evolution of a pre and post lens tear film with a contact lens

    Science.gov (United States)

    Gerhart, Matthew; Anderson, Daniel

    2012-11-01

    The work is the development, implementation, and analysis of a two-dimensional tear film model including a porous contact lens. The geometry of the problem is: a pre-lens layer that is a thin tear film between the outside air and contact lens, a contact lens that is a rigid but movable porous substrate, and a post-lens layer that is a thin film layer between the contact lens and the cornea. We are looking at short and long term behavior of the evolution of the thin film in the pre-lens layer coupled with the porous layer and the thin squeeze film in the post-lens layer. We model the different behaviors that arise as the Darcy number, evaporation effects, and boundary flux conditions change.

  1. Gaussian laser beam transformation into an optical vortex beam by helical lens

    CERN Document Server

    Janicijevic, Ljiljana

    2015-01-01

    In this article we investigate the Fresnel diffraction characteristics of the hybrid optical element which is a combination of a spiral phase plate (SPP) with topological charge p and a thin lens with focal length f, named the helical lens (HL). As incident a Gaussian laser beam is treated, having its waist a distance from the HL plane and its axis passing through the centre of the HL. It is shown that the SPP introduces a phase singularity of p-th order to the incident beam, while the lens transforms the beam characteristic parameters. The output light beam is analyzed in detail: its characteristic parameters and focusing properties, amplitude and intensity distributions and the vortex rings profiles and radii, at any z distance behind the HL plane, as well as in the near and far field.

  2. Lateral shear interferometry with holo shear lens

    Science.gov (United States)

    Joenathan, C.; Mohanty, R. K.; Sirohi, R. S.

    1984-12-01

    A simple method for obtaining lateral shear using holo shear lenses (HSL) has been discussed. This simple device which produces lateral shears in the orthogonal directions has been used for lens testing. The holo shear lens is placed at or near the focus of the lens to be tested. It has also been shown that HSL can be used in speckle shear interferometry as it performs both the functions of shearing and imaging.

  3. An inverse and analytic lens design method

    OpenAIRE

    Lu, Yang; Lakshminarayanan, Vasudevan

    2016-01-01

    Traditional lens design is a numerical and forward process based on ray tracing and aberration theory. This method has limitations because the initial configuration of the lens has to be specified and the aberrations of the lenses have to considered. This paper is an initial attempt to investigate an analytic and inverse lens design method, called Lagrange, to overcome these barriers. Lagrange method tries to build differential equations in terms of the system parameters and the system input ...

  4. Algorithm design of liquid lens inspection system

    Science.gov (United States)

    Hsieh, Lu-Lin; Wang, Chun-Chieh

    2008-08-01

    In mobile lens domain, the glass lens is often to be applied in high-resolution requirement situation; but the glass zoom lens needs to be collocated with movable machinery and voice-coil motor, which usually arises some space limits in minimum design. In high level molding component technology development, the appearance of liquid lens has become the focus of mobile phone and digital camera companies. The liquid lens sets with solid optical lens and driving circuit has replaced the original components. As a result, the volume requirement is decreased to merely 50% of the original design. Besides, with the high focus adjusting speed, low energy requirement, high durability, and low-cost manufacturing process, the liquid lens shows advantages in the competitive market. In the past, authors only need to inspect the scrape defect made by external force for the glass lens. As to the liquid lens, authors need to inspect the state of four different structural layers due to the different design and structure. In this paper, authors apply machine vision and digital image processing technology to administer inspections in the particular layer according to the needs of users. According to our experiment results, the algorithm proposed can automatically delete non-focus background, extract the region of interest, find out and analyze the defects efficiently in the particular layer. In the future, authors will combine the algorithm of the system with automatic-focus technology to implement the inside inspection based on the product inspective demands.

  5. A Magnification Lens for Interactive Volume Visualization

    Energy Technology Data Exchange (ETDEWEB)

    LaMar, E; Hamann, B; Joy, K I

    2001-07-19

    Volume visualization of large data sets suffers from the same problem that many other visualization modalities suffer from: either one can visualize the entire data set and lose small details or visualize a small region and lose the context. In this paper, they present a magnification lens technique for volume visualization. While the notion of a magnification-lens is not new, and other techniques attempt to simulate the physical properties of a magnifying lens, their contribution is in developing a magnification lens that is fast, can be implemented using a fairly small software overhead, and has a natural, intuitive appearance. The issue with magnification lens is the border, or transition, region. The lens center and exterior have a constant zoom factor, and are simple to render. It is the border region that blends between the external and interior magnification, and has a non-constant magnification. They use the perspective-correct textures capability, available in most current graphics systems, to produce a lens with a tessellated border region that approximates linear compression with respect to the radius of the magnification lens. They discuss how a cubic border can mitigate the discontinuities resulting from the use of a linear function, without significant performance loss. They discuss various issues concerning development of a three-dimensional magnification lens.

  6. Trends of contact lens prescribing in Jordan.

    Science.gov (United States)

    Haddad, Mera F; Bakkar, May; Gammoh, Yazan; Morgan, Philip

    2016-10-01

    To evaluate contact lens prescribing trends among optometrists in Jordan. Optometrists from 173 practices in Jordan were surveyed about prescribing contact lenses in their practice. Practitioners were required to record information for the last 10 patients that visited their practice. Demographic data such as age and gender was obtained for each patient. In addition, data relating to lens type, lens design, replacement methods and the care regime advised to each patient were recorded. Practitioners were required to provide information relating to their education and years of experience. The influence of education and experience with respect to lens prescribing trends was explored using linear regression models for the proportions of lens types fitted for patients. A total of 1730 contact lens fits were analyzed. The mean (±SD) age of lens wearers was 26.6 (±7.9) years, of whom 65% were female. Conventional hydrogel lenses were the most prescribed lenses, accounting for 60.3% of the fits, followed by silicone hydrogel lenses (31.3%), and rigid lenses (8.4%). In terms of lens design, spherical lenses appeared to be most commonly prescribed on monthly basis. Daily disposable lenses were second most prescribed lens modality, accounting for 20.4% of the study sample. Multi-purpose solution (MPS) was the preferred care regimen, with a prevalence of 88.1% reported in the study sample, compared to hydrogen peroxide (1-step and 2-step), which represented only 2.8% of the patients in this study. A relationship was established between the two educational groups for rigid lens prescribing (F=17.4, ptrends among optometrists in Jordan. Contact lens prescribing in terms of lens type, lens design, modality of wear and care regimen agree with global market trends with small variations. This report will help practitioners and the industry to detect any deficiencies in the contact lens market in Jordan, which will ease implementing current and future plans in developing contact

  7. A Concept for Zero-Alignment Micro Optical Systems

    Energy Technology Data Exchange (ETDEWEB)

    DESCOUR, MICHAEL R.; KOLOLUOMA,TERHO; LEVEY,RAVIV; RANTALA,JUHA T.; SHUL,RANDY J.; WARREN,MIAL E.; WILLISON,CHRISTI LEE

    1999-09-16

    We are developing a method of constructing compact, three-dimensional photonics systems consisting of optical elements, e.g., lenses and mirrors, photo-detectors, and light sources, e.g., VCSELS or circular-grating lasers. These optical components, both active and passive, are mounted on a lithographically prepared silicon substrate. We refer to the substrate as a micro-optical table (MOT) in analogy with the macroscopic version routinely used in optics laboratories. The MOT is a zero-alignment, microscopic optical-system concept. The position of each optical element relative to other optical elements on the MOT is determined in the layout of the MOT photomask. Each optical element fits into a slot etched in the silicon MOT. The slots are etched using a high-aspect-ratio silicon etching (HARSE) process. Additional positioning features in each slot's cross-section and complementary features on each optical element permit accurate placement of that element's aperture relative to the MOT substrate. In this paper we present the results of the first fabrication and micro-assembly experiments of a silicon-wafer based MOT. Based on these experiments, estimates of position accuracy are reported. We also report on progress in fabrication of lens elements in a hybrid sol-gel material (HSGM). Diffractive optical elements have been patterned in a 13-micron thick HSGM layer on a 150-micron thick soda-lime glass substrate. The measured ms surface roughness was 20 nm. Finally, we describe modeling of MOT systems using non-sequential ray tracing (NSRT).

  8. Short-focus and ultra-wide-angle lens design in wavefront coding

    Science.gov (United States)

    Zhang, Jiyan; Huang, Yuanqing; Xiong, Feibing

    2016-10-01

    Wavefront coding (WFC) is a hybrid technology designed to increase depth of field of conventional optics. The goal of our research is to apply this technology to the short-focus and ultra-wide-angle lens which suffers from the aberration related with large field of view (FOV) such as coma and astigmatism. WFC can also be used to compensate for other aberration which is sensitive to the FOV. Ultra-wide-angle lens has a little depth of focus because it has small F number and short-focus. We design a hybrid lens combing WFC with the ultra-wide-angle lens. The full FOV and relative aperture of the final design are up to170° and 1/1.8 respectively. The focal length is 2 mm. We adopt the cubic phase mask (CPM) in the design. The conventional design will have a wide variation of the point spread function (PSF) across the FOV and it is very sensitive with the variation of the FOV. The new design we obtain the PSF is nearly invariant over the whole FOV. But the result of the design also shows the little difference between the horizontal and vertical length of the PSF. We analyze that the CPM is non-symmetric phase mask and the FOV is so large, which will generate variation in the final image quality. For that reason, we apply a new method to avoid that happened. We try to make the rays incident on the CPM with small angle and decrease the deformation of the PSF. The experimental result shows the new method to optimize the CPM is fit for the ultra-wide-angle lens. The research above will be a helpful instruction to design the ultra-wide-angle lens with WFC.

  9. Coculture with intraocular lens material-activated macrophages induces an inflammatory phenotype in lens epithelial cells.

    Science.gov (United States)

    Pintwala, Robert; Postnikoff, Cameron; Molladavoodi, Sara; Gorbet, Maud

    2015-03-01

    Cataracts are the leading cause of blindness worldwide, requiring surgical implantation of an intraocular lens. Despite evidence of leukocyte ingress into the postoperative lens, few studies have investigated the leukocyte response to intraocular lens materials. A novel coculture model was developed to examine macrophage activation by hydrophilic acrylic (poly(2-hydroxyethyl methacrylate)) and hydrophobic acrylic (polymethylmethacrylate) commercial intraocular lens. The human monocytic cell line THP-1 was differentiated into macrophages and cocultured with human lens epithelial cell line (HLE-B3) with or without an intraocular lens for one, two, four, or six days. Using flow cytometry and confocal microscopy, expression of the macrophage activation marker CD54 (intercellular adhesion molecule-1) and production of reactive oxygen species via the fluorogenic probe 2',7'-dichlorodihydrofluorescein diacetate were examined in macrophages. α-Smooth muscle actin, a transdifferentiation marker, was characterized in lens epithelial cells. The poly(2-hydroxyethyl methacrylate) intraocular lens prevented adhesion but induced significant macrophage activation (p intraocular lens), while the polymethylmethacrylate intraocular lens enabled adhesion and multinucleated fusion, but induced no significant activation. Coculture with either intraocular lens increased reactive oxygen species production in macrophages after one day (p intraocular lens, with hydrophilic surfaces inducing higher activation than hydrophobic surfaces. These findings provide a new method of inquiry into uveal biocompatibility, specifically through the quantification of cell-surface markers of leukocyte activation.

  10. Paediatric intraocular lens implants: accuracy of lens power calculations.

    Science.gov (United States)

    O'Gallagher, M K; Lagan, M A; Mulholland, C P; Parker, M; McGinnity, G; McLoone, E M

    2016-09-01

    PurposeThis study aims to evaluate the accuracy of lens prediction formulae on a paediatric population.MethodsA retrospective case-note review was undertaken of patients under 8 years old who underwent cataract surgery with primary lens implantation in a regional referral centre for paediatric ophthalmology, excluding those whose procedure was secondary to trauma. Biometric and refractive data were analysed for 43 eyes, including prediction errors (PE). Statistical measures used included mean absolute error (MAE), median absolute error (MedAE), Student's t-test and Lin's correlation coefficient.ResultsThe mean PE using the SRK-II formula was +0.96 D (range -2.47D to +2.41 D, SD 1.33 D, MAE 1.38 D, MedAE 1.55, n=15). The mean PE was smaller using SRK/T (-0.18 D, range -3.25 D to +3.95 D, SD 1.70 D, MAE 1.30 D, MedAE 1.24, n=27). We performed an analysis of the biometry data using four different formula (Hoffer Q, Holladay 1, SRK-II and SRK/T). Hoffer Q showed a smaller MedAE than other formulae but also a myopic bias.ConclusionOur clinical data suggest SRK/T was more accurate in predicting post-operative refraction in this cohort of paediatric patients undergoing cataract surgery. Hoffer Q may have improved accuracy further.

  11. Micro Manufacturing

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard

    2003-01-01

    . If a micro manufacturing system isn’t designed rationally and correctly, it will be high-cost, unreliable, and not robust. For micro products and systems it is a continuously increasing challenge to create the operational basis for an industrial production. As the products through product development...... processes are made applicable to a large number of customers, the pressure in regard to developing production technologies that make it possible to produce the products at a reasonable price and in large numbers is growing. The micro/nano manufacturing programme at the Department of Manufacturing...

  12. Spatial filter lens design for the main laser of the National Ignition Facility

    Energy Technology Data Exchange (ETDEWEB)

    Korniski, R. J., Optics 1 Inc, Westlake Village, CA

    1998-06-05

    The National Ignition Facility (NIF), being designed and constructed at Lawrence Livermore National Laboratory (LLNL), comprises 192 laser beams The lasing medium is neodymium in phosphate glass with a fundamental frequency (1{omega}) of 1 053{micro}m Sum frequency generation in a pair of conversion crystals (KDP/KD*P) will produce 1 8 megajoules of the third harmonic light (3{omega} or {lambda}=351{micro}m) at the target The purpose of this paper is to provide the lens design community with the current lens design details of the large optics in the Main Laser This paper describes the lens design configuration and design considerations of the Main Laser The Main Laser is 123 meters long and includes two spatial filters one 13 5 meters and one 60 meters These spatial filters perform crucial beam filtering and relaying functions We shall describe the significant lens design aspects of these spatial filter lenses which allow them to successfully deliver the appropriate beam characteristic onto the target For an overview of NIF please see ``Optical system design of the National Ignition Facility,`` by R Edward English. et al also found in this volume.

  13. Flat lens for seismic waves

    CERN Document Server

    Brule, Stephane; Guenneau, Sebastien

    2016-01-01

    A prerequisite for achieving seismic invisibility is to demonstrate the ability of civil engineers to control seismic waves with artificially structured soils. We carry out large-scale field tests with a structured soil made of a grid consisting of cylindrical and vertical holes in the ground and a low frequency artificial source (< 10 Hz). This allows the identification of a distribution of energy inside the grid, which can be interpreted as the consequence of an effective negative refraction index. Such a flat lens reminiscent of what Veselago and Pendry envisioned for light opens avenues in seismic metamaterials to counteract the most devastating components of seismic signals.

  14. Atom lens without chromatic aberrations

    CERN Document Server

    Efremov, Maxim A; Schleich, Wolfgang P

    2012-01-01

    We propose a lens for atoms with reduced chromatic aberrations and calculate its focal length and spot size. In our scheme a two-level atom interacts with a near-resonant standing light wave formed by two running waves of slightly different wave vectors, and a far-detuned running wave propagating perpendicular to the standing wave. We show that within the Raman-Nath approximation and for an adiabatically slow atom-light interaction, the phase acquired by the atom is independent of the incident atomic velocity.

  15. Intraocular lens with accommodation capacity

    OpenAIRE

    Dorronsoro, Carlos; Alejandre, Nicolás; Bekesi, Nandor; Marcos, Susana

    2014-01-01

    Intraocular lens with accommodation capacity comprising a first optical member (1) having a dynamic optical power, to which a second optical member (2) with a fixed optical power is affixed, in such a manner that at least a central part of each of one of one of the curved surfaces (2a, 2b) of the second optical member (2) and of at least one of the surfaces (1a, 1b) of the first optical member (1) are in contact with each other, the second optical member (2) and the first optical member (1) p...

  16. Contact lens intolerance: refitting with dual axis lens for corneal refractive therapy

    Science.gov (United States)

    López-López, María; Pelegrín-Sánchez, José Miguel; Sobrado-Calvo, Paloma; García-Ayuso, Diego

    2011-01-01

    Corneal refractive therapy is a non-surgical procedure whose main purpose is to improve uncorrected visual acuity during the day, without spectacles or contact lenses. We report an adult woman who shows contact lens intolerance and does not want to wear eyeglasses. We used dual axis contact lens to improve lens centration. We demonstrate a maintained unaided visual acuity during one year of treatment. In conclusion, we can consider refitting with dual axis lens for corneal refractive therapy as a non-surgical option for patients who show contact lens intolerance.

  17. Hybrid Micro-Electro-Mechanical Tunable Filter

    Science.gov (United States)

    2007-09-01

    cladding layers for oxide-aperture current confinement. Finally, the bottom DBR (DBR2) was 55 pairs of quarter-λD layers of GaAs/Al0.04Ga0.96As. The...total thickness of 2.4957µm. Next followed a half-λD cavity consisting of four quantum wells surrounded by high Al mole-fraction cladding layers for...steps described earlier. 5.3.2 Au-Au Flip-Bonding. As discussed in Chapter II, the MUMPsr foundry process provides a design option to deposit a chrome

  18. 显微介导的远缘基因渐渗技术在鲤育种中的应用%Introgressive hybridization of exogenous gene by micro-injection in carp(Cyprinus carpio L.)breeding

    Institute of Scientific and Technical Information of China (English)

    闫学春; 张晓峰; 刘翠; 孙效文; 梁利群; 曹顶臣; 李超; 葛彦龙

    2011-01-01

    carp by introgressive hybridization technology. In this study, transgenic carp progenies were constructed by transferring all-fish gene of shrimp (Fenneropenaeus chinensis) to the zygote of common carp (Cyprinus carpio L.) using mature micro-injection technology. AFLP technology was used to identify the transgenic zygote.The results of genotype of 30 pairs of AFLP markers and analysis of nutrient content of muscle showed that: (1)The gene of shrimp were detected in genome of transgenic carp by 30 pairs of primers of AFLP of shrimp which confirmed that the genomic fragment of shrimp exists in transgenic carp and has no found in contrast ones, then indicates that it should be feasible to transmit genetic material between two distant related species by transgenic method at molecular level. (2) The statistic analysis showed that the contents of crude protein of transgenic carps were 18.37%, 18.47% and 17.99%, which were higher than those in non-transgenic ones(17.06%). Total amino acids contents were 17.16%, 17.56% and 16.92% respectively, also higher than that of control (16.13%), of which 4 kinds of amino acids contents in transgenic carp related to taste were higher than those in common carp significantly(P<0.05), such as aspartic, glutamic, glycin and alanine. So, the effects of shrimp gene directly transmitted to the carp genome gives rise to increase nutrient content and amino acids. This method would be useful in improving carp muscle quality and heredity base, and was a very powerful technology for exogenous DNA transferred between distant related species. In the future, more and more good trait of fish or other species would be improved by this technology, although this technique needs developing further. Transgenic fish will be used in farm after it is tested no harm to ecosystem and human beings. [Journal of Fishery Sciences of China, 2011,18(2): 275-282

  19. Fabricating customized hydrogel contact lens

    Science.gov (United States)

    Childs, Andre; Li, Hao; Lewittes, Daniella M.; Dong, Biqin; Liu, Wenzhong; Shu, Xiao; Sun, Cheng; Zhang, Hao F.

    2016-10-01

    Contact lenses are increasingly used in laboratories for in vivo animal retinal imaging and pre-clinical studies. The lens shapes often need modification to optimally fit corneas of individual test subjects. However, the choices from commercially available contact lenses are rather limited. Here, we report a flexible method to fabricate customized hydrogel contact lenses. We showed that the fabricated hydrogel is highly transparent, with refractive indices ranging from 1.42 to 1.45 in the spectra range from 400 nm to 800 nm. The Young’s modulus (1.47 MPa) and hydrophobicity (with a sessile drop contact angle of 40.5°) have also been characterized experimentally. Retinal imaging using optical coherence tomography in rats wearing our customized contact lenses has the quality comparable to the control case without the contact lens. Our method could significantly reduce the cost and the lead time for fabricating soft contact lenses with customized shapes, and benefit the laboratorial-used contact lenses in pre-clinical studies.

  20. Plasma Lens for Muon and Neutrino Beams

    Energy Technology Data Exchange (ETDEWEB)

    Kahn,S.A.; Korenev, S.; Bishai, M.; Diwan, M.; Gallardo, J.C.; Hershcovitch, A.; Johnson, B.M.

    2008-06-23

    The plasma lens is examined as an alternate to focusing horns and solenoids for use in a neutrino or muon beam facility. The plasma lens concept is based on a combined high-energy lens/target configuration. The current is fed at electrodes located upstream and downstream from the target where pion capturing is needed. The current flows primarily in the plasma, which has a lower resistivity than the target. A second plasma lens section, with an additional current feed, follows the target to provide shaping of the plasma for optimum focusing. The plasma lens is immersed in an additional solenoid magnetic field to facilitate the plasma stability. The geometry of the plasma is shaped to provide optimal pion capture. Simulations of this plasma lens system have shown a 25% higher neutrino production than the horn system. Plasma lenses have the additional advantage of negligible pion absorption and scattering by the lens material and reduced neutrino contamination during anti-neutrino running. Results of particle simulations using plasma lens will be presented.

  1. Liquid lens using acoustic radiation force.

    Science.gov (United States)

    Koyama, Daisuke; Isago, Ryoichi; Nakamura, Kentaro

    2011-03-01

    A liquid lens is proposed that uses acoustic radiation force with no mechanical moving parts. It consists of a cylindrical acrylic cell filled with two immiscible liquids (degassed water and silicone oil) and a concave ultrasound transducer. The focal point of the transducer is located on the oil-water interface, which functions as a lens. The acoustic radiation force is generated when there is a difference in the acoustic energy densities of different media. An acoustic standing wave was generated in the axial direction of the lens and the variation of the shape of the oil-water interface was observed by optical coherence tomography (OCT). The lens profile can be rapidly changed by varying the acoustic radiation force from the transducer. The kinematic viscosity of silicone oil was optimized to minimize the response times of the lens. Response times of 40 and 80 ms when switching ultrasonic radiation on and off were obtained with a kinematic viscosity of 200 cSt. The path of a laser beam transmitted through the lens was calculated by ray-tracing simulations based on the experimental results obtained by OCT. The transmitted laser beam could be focused by applying an input voltage. The liquid lens could be operated as a variable-focus lens by varying the input voltage.

  2. Metasurface lens: Shrinking the camera size

    Science.gov (United States)

    Sun, Cheng

    2017-01-01

    A miniaturized camera has been developed by integrating a planar metasurface lens doublet with a CMOS image sensor. The metasurface lens doublet corrects the monochromatic aberration and thus delivers nearly diffraction-limited image quality over a wide field of view.

  3. Managing as designing with a positive lens

    NARCIS (Netherlands)

    Avital, M.; Boland, R.J.; Avital, M.; Boland, R.J.; Cooperrider, D.L.

    2007-01-01

    The role and potential contribution of a positive lens to the design of systems and organizations is the focus of this essay. The positive lens refers to an emerging perspective in the social sciences that emphasizes a positive stance toward our capacity to construct better organizations and technol

  4. Optimization of Zoom Lens with Discrete State of Liquid Lens Elements by Using Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Cheng-Mu Tsai

    2015-01-01

    Full Text Available This paper is to employ liquid lens elements to design a lens with zoom function by using the genetic algorithm (GA optimization. The liquid lens elements used in the proposal can apply voltage adjustment to generate the electrical field that induces the liquid with electric conductivity to vary the surface curvature between two different kinds of liquids. According to the voltage level, the liquid lens element makes the discrete variation of the curvature and thickness realize the zoom function without moving the lens groups so that the overall length can be reduced. However, it is difficult to design the zoom lens under the discrete variation of the curvature and thickness in the liquid lens elements and the mechanical space that is constantly limited. The GA offers a flexible way for lens optimization. We regarded the spot size as the fitness function to look for the optimum curvatures, thickness, and the corresponding statuses of liquid lens elements for the zoom lens. As a result, the zoom lens with constant space can be realized by running the selection, crossover, and mutation operation in the GA optimization.

  5. Levitated micro-accelerometer.

    Energy Technology Data Exchange (ETDEWEB)

    Warne, Larry Kevin; Schmidt, Carrie Frances; Peterson, Kenneth Allen; Kravitz, Stanley H.; Renn, Rosemarie A.; Peter, Frank J.; Kinney, Ragon D.; Gilkey, Jeffrey C.

    2004-06-01

    The objective is a significant advancement in the state-of-the-art of accelerometer design for tactical grade (or better) applications. The design goals are <1 milli-G bias stability across environments and $200 cost. This quantum leap in performance improvement and cost reduction can only be achieved by a radical new approach, not incremental improvements to existing concepts. This novel levitated closed-loop accelerometer is implemented as a hybrid micromachine. The hybrid approach frees the designer from the limitations of any given monolithic process and dramatically expands the available design space. The design can be tailored to the dynamic range, resolution, bandwidth, and environmental requirements of the application while still preserving all of the benefits of monolithic MEMS fabrication - extreme precision, small size, low cost, and low power. An accelerometer was designed and prototype hardware was built, driving the successful development and refinement of several 'never been done before' fabrication processes. Many of these process developments are commercially valuable and are key enablers for the realization of a wide variety of useful micro-devices. While controlled levitation of a proof mass has yet to be realized, the overall design concept remains sound. This was clearly demonstrated by the stable and reliable closed-loop control of a proof mass at the test structure level. Furthermore, the hybrid MEMS implementation is the most promising approach for achieving the ambitious cost and performance targets. It is strongly recommended that Sandia remain committed to the original goal.

  6. Bacterial assay of contact lens wearers.

    Science.gov (United States)

    Hart, D E; Hosmer, M; Georgescu, M; Farris, R L

    1996-03-01

    The goal of the project was to determine the quantity of bacteria on the contact lens and adjacent areas of the eye. This paper is a quantitative study of the contact lens and ocular aerobic microbiota in a mixed group of daily and extended wear disposable contact lens users. The contact lens, the lower fornix, tears collecting at the lower fornix, and edge of the lower lid at the Meibomian gland margin were assayed for the quantity of bacterial colony forming units (CFU). Eighteen patients wearing 49 disposable high water content hydrogel contact lenses were assayed and the mean lens age was 8.8 +/- 4.6 days. Three patients wore their lenses on a daily wear basis and 15 on an extended wear schedule. Tear samples were obtained with sterile microbial loops and the lens was macerated into small particles with a tissue grinder. The samples were poured onto the surface of chocolate agar plates and incubated at 35 degrees C for 48 h in 5% Co2. The lid margin revealed the greatest bacterial presence (mean = 9.7 CFU; median = 2 CFU; mode = 0 CFU). The lens showed the next greatest presence of CFU (mean = 4.5 CFU; median = 1 CFU; mode = 0). The fornix and tears revealed the least bacterial presence (fornix: mean = 2.6 CFU; median = 0 CFU; mode = 0 CFU). The bacteria were coagulase-negative staphylococci. The bacterial assay of disposable lens wearing contact lens subjects indicates that the lid margins are the greatest source of bacteria with the tears being the lowest. These studies support the concept that in the eye, the lens typically does not possess a large number of bacteria under normal conditions.

  7. Hybrid vehicles

    Energy Technology Data Exchange (ETDEWEB)

    West, J.G.W. [Electrical Machines (United Kingdom)

    1997-07-01

    The reasons for adopting hybrid vehicles result mainly from the lack of adequate range from electric vehicles at an acceptable cost. Hybrids can offer significant improvements in emissions and fuel economy. Series and parallel hybrids are compared. A combination of series and parallel operation would be the ideal. This can be obtained using a planetary gearbox as a power split device allowing a small generator to transfer power to the propulsion motor giving the effect of a CVT. It allows the engine to run at semi-constant speed giving better fuel economy and reduced emissions. Hybrid car developments are described that show the wide range of possible hybrid systems. (author)

  8. Eye vision system using programmable micro-optics and micro-electronics

    Science.gov (United States)

    Riza, Nabeel A.; Amin, M. Junaid; Riza, Mehdi N.

    2014-02-01

    Proposed is a novel eye vision system that combines the use of advanced micro-optic and microelectronic technologies that includes programmable micro-optic devices, pico-projectors, Radio Frequency (RF) and optical wireless communication and control links, energy harvesting and storage devices and remote wireless energy transfer capabilities. This portable light weight system can measure eye refractive powers, optimize light conditions for the eye under test, conduct color-blindness tests, and implement eye strain relief and eye muscle exercises via time sequenced imaging. Described is the basic design of the proposed system and its first stage system experimental results for vision spherical lens refractive error correction.

  9. Micro Manufacturing

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard

    2003-01-01

    Manufacturing deals with systems that include products, processes, materials and production systems. These systems have functional requirements, constraints, design parameters and process variables. They must be decomposed in a systematic manner to achieve the best possible system performance....... If a micro manufacturing system isn’t designed rationally and correctly, it will be high-cost, unreliable, and not robust. For micro products and systems it is a continuously increasing challenge to create the operational basis for an industrial production. As the products through product development...... processes are made applicable to a large number of customers, the pressure in regard to developing production technologies that make it possible to produce the products at a reasonable price and in large numbers is growing. The micro/nano manufacturing programme at the Department of Manufacturing...

  10. Nanostructured Fiber Optic Cantilever Arrays and Hybrid MEMS Sensors for Chemical and Biological Detection Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Advancements in nano-/micro-scale sensor fabrication and molecular recognition surfaces offer promising opportunities to develop miniaturized hybrid fiber optic and...

  11. Dual-beam laser autofocusing system based on liquid lens

    Science.gov (United States)

    Zhang, Fumin; Yao, Yannan; Qu, Xinghua; Zhang, Tong; Pei, Bing

    2017-02-01

    A dual-beam laser autofocusing system is designed in this paper. The autofocusing system is based on a liquid lens with less moving parts and fast response time, which makes the system simple, reliable, compact and fast. A novel scheme "Time-sharing focus, fast conversion" is innovatively proposed. The scheme effectively solves the problem that the guiding laser and the working laser cannot focus at the same target point because of the existence of chromatic aberration. This scheme not only makes both guiding laser and working laser achieve optimal focusing in guiding stage and working stage respectively, but also greatly reduces the system complexity and simplifies the focusing process as well as makes autofocusing time of the working laser reduce to about 10 ms. In the distance range of 1 m to 30 m, the autofocusing spot size is kept under 4.3 mm at 30 m and just 0.18 mm at 1 m. The spot size is much less influenced by the target distance compared with the collimated laser with a micro divergence angle for its self-adaptivity. The dual-beam laser autofocusing system based on liquid lens is fully automatic, compact and efficient. It is fully meet the need of dynamicity and adaptivity and it will play an important role in a number of long-range control applications.

  12. Conjugate metamaterials and the perfect lens

    CERN Document Server

    Xu, Yadong; Xu, Lin; Chen, Huanyang

    2015-01-01

    In this letter, we show how transformation optics makes it possible to design what we call conjugate metamaterials. We show that these materials can also serve as substrates for making a subwavelength-resolution lens. The so-called "perfect lens", which is a lens that could focus all components of light (including propagating and evanescent waves), can be regarded as a limiting case, in which the respective conjugate metamaterials approach the characteristics of left-handed metamaterials, which have a negative refractive index.

  13. PMMA lens with high efficiency and reliability

    Science.gov (United States)

    Matsuzaki, Ichiro; Abe, Koji; Fujita, Katsuhiro

    2013-09-01

    Polymethyl Methacrylate (PMMA) Fresnel lenses are increasingly being used in concentrated photovoltaic (CPV) systems installed outdoors and, accordingly, emphasis is being placed on the durability of such lenses with regard to light transmittance when subject to ultraviolet (UV) light and dust exposure. Accelerated testing methods for evaluating durability under UV exposure were established, allowing development of a lens material with improved UV resistance. Simultaneously, through a proprietary molding method, a Fresnel lens that boasts favorable light concentration efficiency with little deformation even after prolonged outdoor use was developed. Moreover, the lens incorporates a new hard-coat finish that possesses sand durability and UV resistance comparable to that of tempered glass.

  14. Collaborations among Diverse Support Areas for Hybrid Success

    Science.gov (United States)

    Haggar, Faye; Kelley, Bruce; Chen, Weichao

    2017-01-01

    Successful implementation of hybrid courses typically demands collaboration among diverse support areas on campus. This article examines these collaborations through the lens of Badrul Khan's theory of managing blended learning support. Also discussed is the central role that faculty developers can play in connecting these support areas to ensure…

  15. Bionic intraocular lens with variable focus and integrated structure

    Science.gov (United States)

    Liang, Dan; Wang, Xuan-Yin; Du, Jia-Wei; Xiang, Ke

    2015-10-01

    This paper proposes a bionic accommodating intraocular lens (IOL) for ophthalmic surgery. The designed lens has a solid-liquid mixed integrated structure, which mainly consists of a support ring, elastic membrane, rigid lens, and optical liquid. The lens focus can be adjusted through the deformation of the lens front surface when compressed. The integrated structure of the IOL is presented, as well as a detailed description of the lens materials and fabrication process. Images under different radial pressures are captured, and the lens deformation process, accommodating range, density, and optical property are analyzed. The designed lens achieves a 14.6 D accommodating range under a radial pressure of 51.4 mN and a 0.24 mm alteration of the lens outer radius. The deformation property of the lens matches well with the characteristic of the eye and shows the potential to help patients fully recover their vision accommodation ability after the cataract surgery.

  16. Restoring lens capsule integrity enhances lens regeneration in New Zealand albino rabbits and cats.

    Science.gov (United States)

    Gwon, A; Gruber, L J; Mantras, C

    1993-11-01

    In studies conducted by numerous investigators for 150 years, lenses regenerated following endocapsular lens extraction in New Zealand albino rabbits have been irregular in shape, appearing primarily doughnut-shaped as a result of lack of lens growth at the site of the anterior capsulotomy and its adhesion to the posterior capsule. In the present study, we restored the lens capsule integrity by inserting a collagen patch at the time of surgery to seal the anterior capsulotomy and to improve the shape and structure of the regenerated lenses. We then filled the capsule bag with air to prevent adhesions between the anterior and posterior capsule and maintain capsule tautness and shape. Lens regeneration was first noted as early as one to two weeks. Regenerated lens filled approximately 50% of the capsule bag at two weeks and 100% by five weeks. Subsequent growth was in the anterior-posterior direction and measured by A-scan biometry. Lens thickness increased by 0.3 mm per month. The regenerated lenses were spherical with normal cortical structure and a nuclear opacity. In conclusion, restoration of lens capsular integrity with a collagen patch following endocapsular lens extraction enhanced the shape, structure, and growth rate of the regenerated lenses. In addition, lens regeneration was shown to occur in two cats.

  17. Conjunctival Microbiome Changes Associated With Soft Contact Lens and Orthokeratology Lens Wearing.

    Science.gov (United States)

    Zhang, Haikun; Zhao, Fuxin; Hutchinson, Diane S; Sun, Wenfeng; Ajami, Nadim J; Lai, Shujuan; Wong, Matthew C; Petrosino, Joseph F; Fang, Jianhuo; Jiang, Jun; Chen, Wei; Reinach, Peter S; Qu, Jia; Zeng, Changqing; Zhang, Dake; Zhou, Xiangtian

    2017-01-01

    Usage of different types of contact lenses is associated with increased risk of sight-threatening complications. Changes in the ocular microbiome caused by contact lens wear are suggested to affect infection development in those individuals. To address this question, this study compares conjunctival microbial communities in contact lens wearers with those in noncontact lens wearers. Paired-end sequencing of the V3 region of the 16S rRNA gene was used to characterize the bacterial communities on the conjunctival surfaces of contact lens wearers and nonwearers. No differences in microbial diversity were detected between contact lens wearers and nonwearers. Nevertheless, some slight microbe variability was evident between these two different groups. Bacillus, Tatumella and Lactobacillus abundance was less in orthokeratology lens (OKL) wearers than in nonwearers. In soft contact lenses (SCL) wearers, Delftia abundance decreased whereas Elizabethkingia levels increased. The difference in the SCL and nonwearer group was smaller than that in the OKL group. Variations in the conjunctival taxonomic composition between SCL wearers were larger than those in other groups. Sex differences in the conjunctival microbiota makeup were only evident among nonwearers. Even though there were slight percentage changes between contact lens wearers and nonwearers in some microbes, there were no differences in their diversity. On the other hand, contact lens usage might cause relative abundance of some taxa to change. Our results will help assess whether or not conjunctival microbiome changes caused by contact lens wear affect infection risk.

  18. Role of Aquaporin 0 in lens biomechanics

    Energy Technology Data Exchange (ETDEWEB)

    Sindhu Kumari, S.; Gupta, Neha [Physiology and Biophysics, Stony Brook University, Stony Brook, NY (United States); Shiels, Alan [Washington University School of Medicine, St. Louis, MO (United States); FitzGerald, Paul G. [Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA (United States); Menon, Anil G. [University of Cincinnati College of Medicine, Cincinnati, OH (United States); Mathias, Richard T. [Physiology and Biophysics, Stony Brook University, Stony Brook, NY (United States); SUNY Eye Institute, NY (United States); Varadaraj, Kulandaiappan, E-mail: kulandaiappan.varadaraj@stonybrook.edu [Physiology and Biophysics, Stony Brook University, Stony Brook, NY (United States); SUNY Eye Institute, NY (United States)

    2015-07-10

    Maintenance of proper biomechanics of the eye lens is important for its structural integrity and for the process of accommodation to focus near and far objects. Several studies have shown that specialized cytoskeletal systems such as the beaded filament (BF) and spectrin-actin networks contribute to mammalian lens biomechanics; mutations or deletion in these proteins alters lens biomechanics. Aquaporin 0 (AQP0), which constitutes ∼45% of the total membrane proteins of lens fiber cells, has been shown to function as a water channel and a structural cell-to-cell adhesion (CTCA) protein. Our recent ex vivo study on AQP0 knockout (AQP0 KO) mouse lenses showed the CTCA function of AQP0 could be crucial for establishing the refractive index gradient. However, biomechanical studies on the role of AQP0 are lacking. The present investigation used wild type (WT), AQP5 KO (AQP5{sup −/−}), AQP0 KO (heterozygous KO: AQP0{sup +/−}; homozygous KO: AQP0{sup −/−}; all in C57BL/6J) and WT-FVB/N mouse lenses to learn more about the role of fiber cell AQPs in lens biomechanics. Electron microscopic images exhibited decreases in lens fiber cell compaction and increases in extracellular space due to deletion of even one allele of AQP0. Biomechanical assay revealed that loss of one or both alleles of AQP0 caused a significant reduction in the compressive load-bearing capacity of the lenses compared to WT lenses. Conversely, loss of AQP5 did not alter the lens load-bearing ability. Compressive load-bearing at the suture area of AQP0{sup +/−} lenses showed easy separation while WT lens suture remained intact. These data from KO mouse lenses in conjunction with previous studies on lens-specific BF proteins (CP49 and filensin) suggest that AQP0 and BF proteins could act co-operatively in establishing normal lens biomechanics. We hypothesize that AQP0, with its prolific expression at the fiber cell membrane, could provide anchorage for cytoskeletal structures like BFs and

  19. Ensuring Safe Use of Contact Lens Solution

    Science.gov (United States)

    ... evaluating contact lens solutions and the development of Acanthamoeba keratitis, a rare but serious eye infection that's ... contact lenses to water has been associated with Acanthamoeba keratitis, a corneal infection that is resistant to ...

  20. Role of Aquaporin 0 in lens biomechanics.

    Science.gov (United States)

    Sindhu Kumari, S; Gupta, Neha; Shiels, Alan; FitzGerald, Paul G; Menon, Anil G; Mathias, Richard T; Varadaraj, Kulandaiappan

    2015-07-10

    Maintenance of proper biomechanics of the eye lens is important for its structural integrity and for the process of accommodation to focus near and far objects. Several studies have shown that specialized cytoskeletal systems such as the beaded filament (BF) and spectrin-actin networks contribute to mammalian lens biomechanics; mutations or deletion in these proteins alters lens biomechanics. Aquaporin 0 (AQP0), which constitutes ∼45% of the total membrane proteins of lens fiber cells, has been shown to function as a water channel and a structural cell-to-cell adhesion (CTCA) protein. Our recent ex vivo study on AQP0 knockout (AQP0 KO) mouse lenses showed the CTCA function of AQP0 could be crucial for establishing the refractive index gradient. However, biomechanical studies on the role of AQP0 are lacking. The present investigation used wild type (WT), AQP5 KO (AQP5(-/-)), AQP0 KO (heterozygous KO: AQP0(+/-); homozygous KO: AQP0(-/-); all in C57BL/6J) and WT-FVB/N mouse lenses to learn more about the role of fiber cell AQPs in lens biomechanics. Electron microscopic images exhibited decreases in lens fiber cell compaction and increases in extracellular space due to deletion of even one allele of AQP0. Biomechanical assay revealed that loss of one or both alleles of AQP0 caused a significant reduction in the compressive load-bearing capacity of the lenses compared to WT lenses. Conversely, loss of AQP5 did not alter the lens load-bearing ability. Compressive load-bearing at the suture area of AQP0(+/-) lenses showed easy separation while WT lens suture remained intact. These data from KO mouse lenses in conjunction with previous studies on lens-specific BF proteins (CP49 and filensin) suggest that AQP0 and BF proteins could act co-operatively in establishing normal lens biomechanics. We hypothesize that AQP0, with its prolific expression at the fiber cell membrane, could provide anchorage for cytoskeletal structures like BFs and together they help to confer

  1. Veselago lens by photonic hyper-crystals

    CERN Document Server

    Huang, Zun

    2014-01-01

    An imaging system functioning as a Veselago lens has been proposed based on the novel concept of photonic "hyper-crystal" -- an artificial optical medium synthesizing the properties of hyperbolic materials and photonic crystals. This Veselago lens shows a nearly constant negative refractive index and substantially reduced image aberrations. It can find potential applications in photolithography and hot-spots detection of silicon-based integrated circuits.

  2. Lens Design Using Group Indices of Refraction

    Science.gov (United States)

    Vaughan, A. H.

    1995-01-01

    An approach to lens design is described in which the ratio of the group velocity to the speed of light (the group index) in glass is used, in conjunction with the more familiar phase index of refraction, to control certain chromatic properties of a system of thin lenses in contact. The first-order design of thin-lens systems is illustrated by examples incorporating the methods described.

  3. In vivo human crystalline lens topography

    OpenAIRE

    Ortiz, Sergio; Pérez Merino, Pablo; Gambra, Enrique; Castro, Alberto; Marcos, Susana

    2012-01-01

    Custom high-resolution high-speed anterior segment spectral domain optical coherence tomography (OCT) was used to characterize three-dimensionally (3-D) the human crystalline lens in vivo. The system was provided with custom algorithms for denoising and segmentation of the images, as well as for fan (scanning) and optical (refraction) distortion correction, to provide fully quantitative images of the anterior and posterior crystalline lens surfaces. The method was tested on an artificial eye ...

  4. A Spectrometer Based on Diffractive Lens

    Institute of Scientific and Technical Information of China (English)

    WANG Daoyi; YAN Yingbai; JIN Guofan; WU Minxian

    2001-01-01

    A novel spectrometer is designed based on diffractive lens. It is essentially a flat field spectrometer. All the focal points are along the optical axis. Besides, all the asymmetrical aberrations vanish in our mounting. Thus low aberration can be obtained. In this article a diffractive lens is modeled as a special grating and analyzed by using a grating-based method. And a stigmatic point is introduced to reduce the aberrations.

  5. Bilateral Pseudoexfoliation Deposits on Intraocular Lens Implants

    OpenAIRE

    Elena Bonafonte Marquez; Sergio Bonafonte Royo

    2015-01-01

    We present a rare case of bilateral pseudoexfoliative deposits on both intraocular lens (IOL) implants in an 83-year-old woman with no other associated pathology, 5 years after cataract surgery. Pseudoexfoliation syndrome is the most common cause of secondary open-angle glaucoma worldwide and these deposits are usually found on the natural lens. The fact that pseudoexfoliative deposits have been found on IOL implants implies the need for a thorough examination in pseudophakic patients, for i...

  6. Introduction to the development of intraocular lens

    Science.gov (United States)

    Li, Yifan; Peng, Runling; Hu, Shuilan; Wei, Maowei; Chen, Jiabi

    2013-08-01

    In order to cure the cataract disease or injuries in eyes, intraocular lens(IOL) has been studied all the time to replace the crystalline lens in human eyes. Researches on IOL are started early from 19th century, and it develops greatly in the hundreds years after. This article introduces several main kinds of IOLs that appear in the development history of IOL, and raises the double-liquid zoom IOL based on electrowetting, which will be the trend of IOL study.

  7. Evolution and the Calcite Eye Lens

    CERN Document Server

    Williams, Vernon L

    2013-01-01

    Calcite is a uniaxial, birefringent crystal, which in its optically transparent form, has been used for animal eye lenses, the trilobite being one such animal. Because of the calcite birefringence there is a difficulty in using calcite as a lens. When the propagation direction of incoming light is not exactly on the c-axis, the mages blur. In this paper, calcite blurring is evaluated, and the non-blurring by a crystallin eye lens is compared to a calcite one.

  8. Laser beam micro-milling of micro-channels in aerospace alloys

    CERN Document Server

    Ahmed, Naveed; Al-Ahmari, Abdulrahman

    2017-01-01

    This volume is greatly helpful to micro-machining and laser engineers as it offers obliging guidelines about the micro-channel fabrications through Nd:YAG laser beam micro-milling. The book also demonstrates how the laser beam micro-milling behaves when operating under wet conditions (under water), and explores what are the pros and cons of this hybrid technique. From the predictive mathematical models, the readers can easily estimate the resulting micro-channel size against the desired laser parametric combinations. The book considers micro-channels in three highly important research materials commonly used in aerospace industry: titanium alloy Ti-6Al-4V, nickel alloy Inconel 718 and aluminum alloy AA 2024. Therefore, the book is highly practicable in the fields of micro-channel heat exchangers, micro-channel aerospace turbine blades, micro-channel heat pipes, micro-coolers and micro-channel pulsating heat plates. These are frequently used in various industries such as aerospace, automotive, biomedical and m...

  9. A correlation of thin lens approximation to thick lens design by using context based method in optics education

    Science.gov (United States)

    Farsakoglu, O. F.; Inal Atik, Ipek; Kocabas, Hikmet

    2014-07-01

    The effect of Coddington factors on aberration functions has been analysed using thin lens approximation with optical glass parameters. The dependence of spherical aberration on Coddington shape factor for the various optical glasses in real lens design was discussed using exact ray tracing for the optics education and training purposes. Thin lens approximation and thick lens design are generally taught with only lecturing method. But, thick lens design is closely related to the real life. Hence, it is more appropriate to teach thin lens approximation and thick lens design with real-life context based approach. Context based teaching can be effective in solving problems in which the subject is very difficult and irrelevant. It also provides extensive evidence for optics education that students are generally unable to correctly apply the concepts of lens design to optical instruments currently used. Therefore, the outline of real-life context based thick lens design lessons were proposed and explained in detail considering thin lens approximation.

  10. Photon nanojet lens: design, fabrication and characterization

    Science.gov (United States)

    Xu, Chen; Zhang, Sichao; Shao, Jinhai; Lu, Bing-Rui; Mehfuz, Reyad; Drakeley, Stacey; Huang, Fumin; Chen, Yifang

    2016-04-01

    In this paper, a novel nanolens with super resolution, based on the photon nanojet effect through dielectric nanostructures in visible wavelengths, is proposed. The nanolens is made from plastic SU-8, consisting of parallel semi-cylinders in an array. This paper focuses on the lens designed by numerical simulation with the finite-difference time domain method and nanofabrication of the lens by grayscale electron beam lithography combined with a casting/bonding/lift-off transfer process. Monte Carlo simulation for injected charge distribution and development modeling was applied to define the resultant 3D profile in PMMA as the template for the lens shape. After the casting/bonding/lift-off process, the fabricated nanolens in SU-8 has the desired lens shape, very close to that of PMMA, indicating that the pattern transfer process developed in this work can be reliably applied not only for the fabrication of the lens but also for other 3D nanopatterns in general. The light distribution through the lens near its surface was initially characterized by a scanning near-field optical microscope, showing a well defined focusing image of designed grating lines. Such focusing function supports the great prospects of developing a novel nanolithography based on the photon nanojet effect.

  11. Lens Biology is a Dimension of Neurobiology.

    Science.gov (United States)

    Frederikse, Peter; Kasinathan, Chinnaswamy

    2017-02-04

    There is a second cell type in your body that expresses scores of the most intensively studied genes in neuroscience and exclusively shares critical interdependent modes of molecular regulation that include a network first described as responsible for the basic bifurcation of neuronal from non-neuronal gene expression in vertebrates. Neurons and lens cells are among the most ancient animal cell types, yet neurons have an exclusive status also attributed to roles underlying sensation, movement, and cognition. However, this status is challenged by cells in the lens of the eye. The extent and detail of internally consistent parallels with neuron biology now catalogued in their second native cell type in the lens provide a detailed model of interdependent neuron gene expression in lens development and non-neuronal role in vision. These comprehensive parallels identify the lens as a dimension of neurobiology and a fundamental new perspective on neurodevelopment and its disorders. Finally, this understanding identifies that hallmark neuronal gene expression and key modes of associated molecular regulation evolved in tandem in the lens.

  12. Conservation through the economics lens.

    Science.gov (United States)

    Farley, Joshua

    2010-01-01

    Although conservation is an inherently transdisciplinary issue, there is much to be gained from examining the problem through an economics lens. Three benefits of such an approach are laid out in this paper. First, many of the drivers of environmental degradation are economic in origin, and the better we understand them, the better we can conserve ecosystems by reducing degradation. Second, economics offers us a when-to-stop rule, which is equivalent to a when-to-conserve rule. All economic production is based on the transformation of raw materials provided by nature. As the economic system grows in physical size, it necessarily displaces and degrades ecosystems. The marginal benefits of economic growth are diminishing, and the marginal costs of ecological degradation are increasing. Conceptually, we should stop economic growth and focus on conservation when the two are equal. Third, economics can help us understand how to efficiently and justly allocate resources toward conservation, and this paper lays out some basic principles for doing so. Unfortunately, the field of economics is dominated by neoclassical economics, which builds an analytical framework based on questionable assumptions and takes an excessively disciplinary and formalistic approach. Conservation is a complex problem, and analysis from individual disciplinary lenses can make important contributions to conservation only when the resulting insights are synthesized into a coherent vision of the whole. Fortunately, there are a number of emerging transdisciplines, such as ecological economics and environmental management, that are dedicated to this task.

  13. Two-photon direct laser writing of ultracompact multi-lens objectives

    Science.gov (United States)

    Gissibl, Timo; Thiele, Simon; Herkommer, Alois; Giessen, Harald

    2016-08-01

    Current lens systems are restricted in size, shape and dimensions by limitations of manufacturing. Multi-lens elements with non-spherical shapes are required for high optical performance and to correct for aberrations when imaging at wide angles and large fields. Here we present a novel concept in optics that overcomes all of the aforementioned difficulties and opens the new field of 3D printed micro- and nano-optics with complex lens designs. We demonstrate the complete process chain, from optical design, manufacturing by femtosecond two-photon direct laser writing and testing to the application of multi-lens objectives with sizes around 100 µm, and validate their high performance and functionality by quantitative measurements of the modulation transfer function and aberrations. The unprecedented flexibility of our method paves the way towards printed optical miniature instruments such as endoscopes, fibre-imaging systems for cell biology, new illumination systems, miniature optical fibre traps, integrated quantum emitters and detectors, and miniature drones and robots with autonomous vision.

  14. Micro Marketing

    Institute of Scientific and Technical Information of China (English)

    Yu Yan

    2012-01-01

    In November the Chinese movie industry experienced a startling surprise.Love Is Not Blind,a low-budget movie with no prominent director or major star,hit 344.8million yuan ($54.5 million) in box office revenue,despite the film's budget was only 9 million yuan ($1.4 million).The film,which tells the 33-day experience of a girl named Huang Xiaoxian after she breaks up with her boyfriend,owes its unexpected blockbusting success to its innovative marketing strategy:micro-blog marketing.The number of followers of the official micro-blog for Love Is Not Blind hit nearly 100,000,attracted by rccommendations of related micro-blog messages,impressive box office lines,and positive word of mouth.By December 7,search queries for Love Is Not Blind had exceeded 8 million.Those for Wang Xiaojian,the lcading male,were close to 1.5 million.

  15. Hybrid Airy Plasmons with Dynamically Steerable Trajectories

    CERN Document Server

    Li, Rujiang; Lin, Xiao; Wang, Huaping; Xu, Zhiwei; Chen, Hongsheng

    2016-01-01

    With the intriguing properties of diffraction-free, self-accelerating, and self-healing, Airy plasmons are promising to be used in the trapping, transporting, and sorting of micro-objects, imaging, and chip scale signal processing. However, the high dissipative loss and the lack of dynamical steerability restrict the implementation of Airy plasmons in these applications. Here we reveal the hybrid Airy plasmons for the first time by taking a hybrid graphene-based plasmonic waveguide in the terahertz (THz) domain as an example. Due to the coupling between an optical mode and a plasmonic mode, the hybrid Airy plasmons can have large propagation lengths and effective transverse deflections, where the transverse waveguide confinements are governed by the hybrid modes with moderate quality factors. Meanwhile, the propagation trajectories of hybrid Airy plasmons are dynamically steerable by changing the chemical potential of graphene. These hybrid Airy plasmons may promote the further discovery of non-diffracting be...

  16. Hybrid Airy plasmons with dynamically steerable trajectories.

    Science.gov (United States)

    Li, Rujiang; Imran, Muhammad; Lin, Xiao; Wang, Huaping; Xu, Zhiwei; Chen, Hongsheng

    2017-01-26

    With their intriguing diffraction-free, self-accelerating, and self-healing properties, Airy plasmons show promise for use in the trapping, transporting, and sorting of micro-objects, imaging, and chip scale signal processing. However, high dissipative loss and lack of dynamical steerability restrict the implementation of Airy plasmons in these applications. Here we reveal hybrid Airy plasmons for the first time by taking a hybrid graphene-based plasmonic waveguide in the terahertz (THz) domain as an example. Due to coupling between optical modes and plasmonic modes, the hybrid Airy plasmons can have large propagation lengths and effective transverse deflections, where the transverse waveguide confinements are governed by the hybrid modes with moderate quality factors. Meanwhile, the propagation trajectories of the hybrid Airy plasmons are dynamically steerable by changing the chemical potential of graphene. These hybrid Airy plasmons may promote the further discovery of non-diffracting beams along with the emerging developments of optical tweezers and tractor beams.

  17. The Sloan Lens ACS Survey. V. The full ACS strong-lens sample

    NARCIS (Netherlands)

    Bolton, Adam S.; Burles, Scott; Koopmans, Leon V. E.; Treu, Tommaso; Gavazzi, Raphael; Moustakas, Leonidas A.; Wayth, Randall; Schlegel, David J.

    2008-01-01

    We present the definitive data for the full sample of 131 strong gravitational lens candidates observed with the Advanced Camera for Surveys (ACS) aboard the Hubble Space Telescope by the Sloan Lens ACS (SLACS) Survey. All targets were selected for higher redshift emission lines and lower redshift

  18. Effect of infusion bottle height on lens power after lens refilling with and without a plug

    NARCIS (Netherlands)

    Koopmans, SA; Terwee, T; Haitjema, HJ; Kooijman, AC; Barkhof, J

    2003-01-01

    Purpose: To evaluate the influence of intraoperative infusion bottle height on the power of refilled pig lenses. Setting: Research Laboratory, Pharmacia Intraocular Lens Manufacturing Plant, Groningen, The Netherlands. Methods: This study comprised 2 groups of pig eyes. In 1 group, the lens was refi

  19. Gravitational binary-lens events with prominent effects of lens orbital motion

    Energy Technology Data Exchange (ETDEWEB)

    Park, H.; Han, C.; Choi, J.-Y. [Department of Physics, Institute for Astrophysics, Chungbuk National University, Cheongju 371-763 (Korea, Republic of); Udalski, A.; Szymański, M. K.; Kubiak, M.; Soszyński, I.; Pietrzyński, G.; Poleski, R.; Ulaczyk, K.; Pietrukowicz, P.; Kozłowski, S.; Skowron, J.; Wyrzykowski, Ł. [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478 Warszawa (Poland); Gould, A.; Gaudi, B. S. [Department of Astronomy, The Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Beaulieu, J.-P. [Institut d' Astrophysique de Paris, UMR 7095 CNRS-Université Pierre and Marie Curie, 98bis Bd Arago, F-75014 Paris (France); Tsapras, Y. [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Suite 102, Goleta, CA 93117 (United States); Depoy, D. L. [Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843 (United States); Dong, Subo [Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540 (United States); Collaboration: OGLE Collaboration; μFUN Collaboration; PLANET Collaboration; RoboNet Collaboration; and others

    2013-12-01

    Gravitational microlensing events produced by lenses composed of binary masses are important because they provide a major channel for determining physical parameters of lenses. In this work, we analyze the light curves of two binary-lens events, OGLE-2006-BLG-277 and OGLE-2012-BLG-0031, for which the light curves exhibit strong deviations from standard models. From modeling considering various second-order effects, we find that the deviations are mostly explained by the effect of the lens orbital motion. We also find that lens parallax effects can mimic orbital effects to some extent. This implies that modeling light curves of binary-lens events not considering orbital effects can result in lens parallaxes that are substantially different from actual values and thus wrong determinations of physical lens parameters. This demonstrates the importance of routine consideration of orbital effects in interpreting light curves of binary-lens events. It is found that the lens of OGLE-2006-BLG-277 is a binary composed of a low-mass star and a brown dwarf companion.

  20. The Sloan Lens ACS Survey. V. The full ACS strong-lens sample

    NARCIS (Netherlands)

    Bolton, Adam S.; Burles, Scott; Koopmans, Leon V. E.; Treu, Tommaso; Gavazzi, Raphael; Moustakas, Leonidas A.; Wayth, Randall; Schlegel, David J.

    2008-01-01

    We present the definitive data for the full sample of 131 strong gravitational lens candidates observed with the Advanced Camera for Surveys (ACS) aboard the Hubble Space Telescope by the Sloan Lens ACS (SLACS) Survey. All targets were selected for higher redshift emission lines and lower redshift c

  1. DISSECTING THE GRAVITATIONAL LENS B1608+656. I. LENS POTENTIAL RECONSTRUCTION

    NARCIS (Netherlands)

    Suyu, S. H.; Marshall, P. J.; Blandford, R. D.; Fassnacht, C. D.; Koopmans, L. V. E.; McKean, J. P.; Treu, T.

    2009-01-01

    Strong gravitational lensing is a powerful technique for probing galaxy mass distributions and for measuring cosmological parameters. Lens systems with extended source-intensity distributions are particularly useful for this purpose since they provide additional constraints on the lens potential ( m

  2. Softec HD hydrophilic acrylic intraocular lens: biocompatibility and precision

    Directory of Open Access Journals (Sweden)

    Ladan Espandar

    2011-01-01

    Full Text Available Ladan Espandar1, Shameema Sikder2, Majid Moshirfar31Department of Ophthalmology, Tulane University, New Orleans, LA, USA; 2Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA; 3John A Moran Eye Center, University of Utah, Salt Lake City, UT, USAAbstract: Intraocular lens development is driven by higher patient expectations for ideal visual outcomes. The recently US Food and Drug Administration-approved Softec HD™ lens is an aspheric, hydrophilic acrylic intraocular lens (IOL. The hydrophilic design of the lens is optimized to address dysphotopsia while maintaining biocompatibility, optical clarity, resistance to damage, and resistance to biocontamination. Aspheric lenses decrease postoperative spherical aberration. The addition of the Softec lens provides clinicians with another option for IOL placement; however, randomized comparative studies of this lens to others already on the market remain to be completed.Keywords: hydrophilic acrylic intraocular lens, Softec HD intraocular lens, aspheric intraocular lens, IOL

  3. An improved spinning lens test to determine the stiffness of the human lens

    Science.gov (United States)

    Burd, H.J.; Wilde, G.S.; Judge, S.J.

    2011-01-01

    It is widely accepted that age-related changes in lens stiffness are significant for the development of presbyopia. However, precise details on the relative importance of age-related changes in the stiffness of the lens, in comparison with other potential mechanisms for the development of presbyopia, have not yet been established. One contributing factor to this uncertainty is the paucity and variability of experimental data on lens stiffness. The available published data generally indicate that stiffness varies spatially within the lens and that stiffness parameters tend to increase with age. However, considerable differences exist between these published data sets, both qualitatively and quantitatively. The current paper describes new and improved methods, based on the spinning lens approach pioneered by Fisher, R.F. (1971) ‘The elastic constants of the human lens’, Journal of Physiology, 212, 147–180, to make measurements on the stiffness of the human lens. These new procedures have been developed in an attempt to eliminate, or at least substantially reduce, various systematic errors in Fisher’s original experiment. An improved test rig has been constructed and a new modelling procedure for determining lens stiffness parameters from observations made during the test has been devised. The experiment involves mounting a human lens on a vertical rotor so that the lens spins on its optical axis (typically at 1000 rpm). An automatic imaging system is used to capture the outline of the lens, while it is rotating, at pre-determined angular orientations. These images are used to quantify the deformations developed in the lens as a consequence of the centripetal forces induced by the rotation. Lens stiffness is inferred using axisymmetric finite element inverse analysis in which a nearly-incompressible neo-Hookean constitutive model is used to represent the mechanics of the lens. A numerical optimisation procedure is used to determine the stiffness parameters

  4. Corneal topography and soft contact lens fit.

    Science.gov (United States)

    Young, Graeme; Schnider, Cristina; Hunt, Chris; Efron, Suzanne

    2010-05-01

    To determine which ocular topography variables affect soft contact lens fit. Fifty subjects each wore three pairs of soft lenses in random succession (Vistakon Acuvue 2, Vistakon Acuvue Advance, Ciba Vision Night & Day), and various aspects of lens fit were evaluated. The steeper base curves of each type were worn in one eye and the flatter base curves in the other eye. Corneal topography data were collected using a Medmont E300 corneal topographer (Camberwell, Australia). Corneal curvature, shape factor (SF), and corneal height were measured over a 10 mm chord and also over the maximum measurable diameter. These were measured in the horizontal, vertical, steepest, and flattest meridians. With each lens type, the steeper base curve provided the best fit on the greatest proportion of eyes and the significant differences in various aspects of fit were noted between base curves. For each lens type, there was no significant difference in mean K-reading between those eyes best fit with the steeper base curve and those eyes best fit with the flatter base curve. Two of the lenses showed a positive correlation between centration and horizontal corneal height (maximum), whereas one lens showed a negative correlation between centration and horizontal SF (SF = e). Several lenses showed a positive correlation between post-blink movement and horizontal or vertical corneal SF. The measurement of corneal topography using current Placido disc instrumentation allows a better prediction of soft lens fit than by keratometry, but it is not reliable enough to enable accurate selection of the best fitting base curve. Some correlations are evident between corneal measurements; however, trial fitting remains the method of choice for selection of soft lens base curve.

  5. On the isolation of elemental carbon (EC for micro-molar 14C accelerator mass spectrometry: development of a hybrid reference material for 14C-EC accuracy assurance, and a critical evaluation of the thermal optical kinetic (TOK EC isolation procedure

    Directory of Open Access Journals (Sweden)

    L. A. Currie

    2005-01-01

    Full Text Available The primary objective of the research reported here has been the development of a hybrid reference material (RM to serve as a test of accuracy for elemental carbon (EC isotopic (14C speciation measurements. Such measurements are vital for the quantitative apportionment of fossil and biomass sources of 'soot' (EC, the tracer of fire that has profound effects on health, atmospheric visibility, and climate. Previous studies of 14C-EC measurement quality, carried out with NIST SRM 1649a (Urban Dust, showed a range of results, but since the 'truth' was not known for this natural matrix RM, one had to rely on isotopic-chemical consistency evidence (14C in PAH, EC of measurement validity (Currie et al., 2002. Components of the new Hybrid RM (DiesApple, however, have known 14C and EC composition, and they are nearly orthogonal (isotopically and chemically. NIST SRM 2975 (Forklift Diesel Soot has little or no 14C, and its major compositional component is EC; SRM 1515 (Apple Leaves has the 14C content of biomass-C, and it has little or no EC. Thus, the Hybrid RM can serve as an absolute isotopic test for the absence of EC-mimicking pyrolysis-C (char from SRM 1515 in the EC isolate of the Hybrid RM, as well as a test for conservation of its dominant soot fraction throughout the isolation procedure. The secondary objective was to employ the Hybrid RM for the comparative evaluation of the thermal optical kinetic (TOK and thermal optical transmission (TOT methods for the isolation of EC for micro-molar carbon accelerator mass spectrometry (AMS. As part of this process, the relatively new TOK method was subjected to a critical evaluation and significant development. Key findings of our study are: (1 both methods exhibited biomass-C 'leakage'; for TOT, the EC fraction isolated for AMS contained about 8% of the original biomass-C; for TOK, the refractory carbon (RC isolated contained about 3% of the original biomass-C.; (2 the initial isothermal oxidation stage

  6. Hybrid Tower, Designing Soft Structures

    DEFF Research Database (Denmark)

    Ramsgaard Thomsen, Mette; Tamke, Martin; Holden Deleuran, Anders;

    2015-01-01

    predictions about the inherent interdependency and material dependent performance of the hybrid structure and (2) the inter-scalar design strategies for specification and fabrication. The first investigation focuses on the design pipelines developed between the implementation of realtime physics...... (membrane reinforcement strategy) and micro scale (design of bespoke textile membrane). The paper concludes with a post construction analysis. Comparing structural and environmental data, the predicted and the actual performance of tower are evaluated and discussed....

  7. Lateral translation micro-tracking of planar micro-optic solar concentrator

    Science.gov (United States)

    Hallas, Justin M.; Karp, Jason H.; Tremblay, Eric J.; Ford, Joseph E.

    2010-08-01

    High-concentration photo-voltaic systems focus incident sunlight by hundreds of times by combining focusing lenses with accurate, dual-axis solar tracking. Conventional systems mount large optical arrays on expensive tracking pedestals to maintain normal incidence throughout the day. A recently proposed micro-optic solar concentrator utilizes a twodimensional lens array focusing into a planar slab waveguide. Localized mirrors fabricated on the waveguide surface reflect focused sunlight into guided modes which propagate towards an edge-mounted photovoltaic cell. This geometry enables a new method of solar tracking by laterally translating the waveguide with respect to the lens array to capture off-axis illumination. Using short focal length lenses, translations on the order of millimeters can efficiently collect 70° full-angle incident fields. This allows for either one or two-axis tracking systems where the small physical motion is contained within the physical footprint of a fixed solar panel. Here, we experimentally demonstrate lateral micro tracking for off-axis light collection using table-mounted components. We also present a novel tracking frame based on de-centered cams and describe a lens configuration optimized for off-axis coupling.

  8. Hybrid Airy Plasmons with Dynamically Steerable Trajectories

    OpenAIRE

    Li, Rujiang; Imran, Muhammad; Lin, Xiao; Wang, Huaping; Xu, Zhiwei; Chen, Hongsheng

    2016-01-01

    With the intriguing properties of diffraction-free, self-accelerating, and self-healing, Airy plasmons are promising to be used in the trapping, transporting, and sorting of micro-objects, imaging, and chip scale signal processing. However, the high dissipative loss and the lack of dynamical steerability restrict the implementation of Airy plasmons in these applications. Here we reveal the hybrid Airy plasmons for the first time by taking a hybrid graphene-based plasmonic waveguide in the ter...

  9. Impact of lens distortions on strain measurements obtained with 2D digital image correlation

    Science.gov (United States)

    Lava, P.; Van Paepegem, W.; Coppieters, S.; De Baere, I.; Wang, Y.; Debruyne, D.

    2013-05-01

    The determination of strain fields based on displacements obtained via digital image correlation (DIC) at the micro-strain level (≤1000 μm/m) is still a cumbersome task. In particular when high-strain gradients are involved, e.g. in composite materials with multidirectional fibre reinforcement, uncertainties in the experimental setup and errors in the derivation of the displacement fields can substantially hamper the strain identification process. In this contribution, the aim is to investigate the impact of lens distortions on strain measurements. To this purpose, we first perform pure rigid body motion experiments, revealing the importance of precise correction of lens distortions. Next, a uni-axial tensile test on a textile composite with spatially varying high strain gradients is performed, resulting in very accurately determined strains along the fibers of the material.

  10. [Representation and mathematical analysis of human crystalline lens].

    Science.gov (United States)

    Tălu, Stefan; Giovanzana, Stefano; Tălu, Mihai

    2011-01-01

    The surface of human crystalline lens can be described and analyzed using mathematical models based on parametric representations, used in biomechanical studies and 3D solid modeling of the lens. The mathematical models used in lens biomechanics allow the study and the behavior of crystalline lens on variables and complex dynamic loads. Also, the lens biomechanics has the potential to improve the results in the development of intraocular lenses and cataract surgery. The paper presents the most representative mathematical models currently used for the modeling of human crystalline lens, both optically and biomechanically.

  11. Hybrid Metaheuristics

    CERN Document Server

    2013-01-01

    The main goal of this book is to provide a state of the art of hybrid metaheuristics. The book provides a complete background that enables readers to design and implement hybrid metaheuristics to solve complex optimization problems (continuous/discrete, mono-objective/multi-objective, optimization under uncertainty) in a diverse range of application domains. Readers learn to solve large scale problems quickly and efficiently combining metaheuristics with complementary metaheuristics, mathematical programming, constraint programming and machine learning. Numerous real-world examples of problems and solutions demonstrate how hybrid metaheuristics are applied in such fields as networks, logistics and transportation, bio-medical, engineering design, scheduling.

  12. Imaging characteristics of a volume holographic lens

    Science.gov (United States)

    Yang, Jing; Jiang, Zhu-qing; Xu, Zhi-qiang; Liu, Shao-jie; Sun, Ya-jun; Tao, Shi-quan

    2009-07-01

    A volume holographic grating lens can reconstruct the three-dimensional information by conducting multiple optical slicing of an object based on Bragg selectivity of the volume holographic grating. In this paper, we employ the point-spread function of volume holographic imaging system to theoretically analyze its imaging resolution. In the experiments, the volume holographic gratings are made with a spherical reference (SR) and a planar reference (PR), respectively, and used as volume holographic imaging lens in our imaging system. The longitudinal and lateral defocusing characteristics of volume holographic lens with SR and with PR are investigated experimentally by displacing the interested objects from original reference location, respectively. The effects of the parameters of the volume holographic lens on the longitudinal and lateral resolution are also discussed. The experimental results show that increasing the size of the volume holographic lens can improve the depth resolution, and in particular, it has greater influence on SR VHI. The lateral selectivity of SR VHI is more sensitive than that of PR VHI, and the Bragg degenerate diffraction of PR VHI on the y axis is obviously observed.

  13. The Extragalactic Lens VLBI Imaging Survey (ELVIS). I. A Search for the Central Image in the Gravitational Lens PMN J1838-3427

    CERN Document Server

    Boyce, E R; Hewitt, J N; Myers, S T; Boyce, Edward R.; Winn, Joshua N.; Hewitt, Jacqueline N.; Myers, Steven T.

    2006-01-01

    The Extragalactic Lens VLBI Imaging Survey (ELVIS) searches for central images of lensed radio quasars, in order to measure the central density profiles of distant galaxies. Here we present sensitive multi-epoch Very Long Baseline Array (VLBA) observations of PMN J1838-3427 at 8 GHz, with a 1 sigma noise level of 38 microJy beam^(-1). Based on the absence of a central image of the background source at this level, we explore the possibilities for the central matter distribution in the lens galaxy. A power-law density profile, rho ~ r^(-gamma), must have gamma > 1.93. Thus the density profile is close to an isothermal profile (gamma = 2) or steeper. The upper limit on any constant-density core in an otherwise isothermal profile is ~< 5 parsecs. We also derive the constraints on models in which the density profile is isothermal on kiloparsec scales, but is allowed to have a different power law in the central ~100 parsecs. If the lens galaxy harbors a supermassive black hole, the galaxy profile is allowed to b...

  14. Apoptosis in the lens anlage of the heritable lens aplastic mouse (lap mouse).

    Science.gov (United States)

    Aso, S; Tashiro, M; Baba, R; Sawaki, M; Noda, S; Fujita, M

    1998-08-01

    Adult homozygous lap mice show various eye abnormalities, such as aphakia, retinal disorganization, and dysplasia of the cornea and anterior chamber. In the fetal eye of a homozygous lap mouse, the lens placode seems to develop normally. However, the lens vesicle progresses abnormally to form a mass of cells without a cavity, and the mass vanishes soon afterward. We examined cell death in the lens anlage of this mutant. The lens anlagen of homozygous lap and normal mice from days 10 to 12 of gestation were observed by light microscopy after DNA end-labeling by immunohistochemistry and by transmission electron microscopy. By light microscopy, a slight frequency of cell death was detected in the lens anlage encircling the surface ectoderm and in the anlage or in the anlage of both homozygous lap mice and normal mice at day 10 of gestation. Cell death was seen in the lens anlage encircling the surface ectoderm in the normal mouse and sporadically in the anlage of the homozygous lap mouse at day 10.5 of gestation. Cell death was visible at the area of the lens vesicle attached to the surface ectoderm and encircling the surrounding surface ectoderm in the normal mouse, and in the lens anlage encircling the surface ectoderm and the apex areas of the lens anlage in the homozygous lap mouse at day 11 of gestation. At day 12 of gestation, almost no cell death was observed in the lens anlage of the normal mouse. However, extensive areas of cell death were still seen in the lens anlage at its apex, at the inner region, and encircling the surface ectoderm in the homozygous lap mouse. Electron microscopic observation showed that the dead cells observed in the lens anlagen by light microscopy in normal and lap mice are the result of apoptosis. In lap mice, cells with cytoplasmic condensation were observed mainly at days 10 and 10.5 of gestation. Many apoptotic bodies which had been phagocytosed by adjacent cells were seen predominantly at day 11 of gestation. At day 12 of

  15. On the isolation of elemental carbon for micro-molar 14C accelerator mass spectrometry; evaluation of alternative isolation procedures, and accuracy assurance using a hybrid isotopic particulate carbon reference material

    Directory of Open Access Journals (Sweden)

    L. A. Currie

    2005-05-01

    Full Text Available The primary objective of the research reported here has been the development of an hybrid reference material (RM to serve as a test of accuracy for elemental carbon (EC isotopic (14C speciation measurements. Such measurements are critically important for the quantitative apportionment of fossil and biomass sources of ''soot'' (EC, the tracer of fire that has profound effects on health, atmospheric visibility, and climate. Previous studies of 14C-EC measurement quality, carried out with NIST SRM 1649a (Urban Dust, showed a range of results, but since the ''truth'' was not known for this natural matrix RM, one had to rely on isotopic-chemical consistency evidence (14C in PAH, EC of measurement validity (Currie et al., 2002. Components of the new Hybrid RM (DiesApple, however, have known 14C and EC composition, and they are nearly orthogonal (isotopically and chemically. NIST SRM 2975 (Forklift Diesel Soot has little or no 14C, and its major compositional component is EC. SRM 1515 (Apple Leaves has the 14C content of biomass-C, and it has little or no EC. Thus, the hybrid RM can serve as an absolute isotopic test for the absence of EC-mimicking pyrolysis-C from SRM 1515 in the EC isolate of the hybrid RM, together with testing for conservation of its dominant soot fraction through the isolation procedure.

  16. Optimal control of hybrid vehicles

    CERN Document Server

    Jager, Bram; Kessels, John

    2013-01-01

    Optimal Control of Hybrid Vehicles provides a description of power train control for hybrid vehicles. The background, environmental motivation and control challenges associated with hybrid vehicles are introduced. The text includes mathematical models for all relevant components in the hybrid power train. The power split problem in hybrid power trains is formally described and several numerical solutions detailed, including dynamic programming and a novel solution for state-constrained optimal control problems based on Pontryagin’s maximum principle.   Real-time-implementable strategies that can approximate the optimal solution closely are dealt with in depth. Several approaches are discussed and compared, including a state-of-the-art strategy which is adaptive for vehicle conditions like velocity and mass. Two case studies are included in the book: ·        a control strategy for a micro-hybrid power train; and ·        experimental results obtained with a real-time strategy implemented in...

  17. Hybrid intermediaries

    OpenAIRE

    Cetorelli, Nicola

    2014-01-01

    I introduce the concept of hybrid intermediaries: financial conglomerates that control a multiplicity of entity types active in the "assembly line" process of modern financial intermediation, a system that has become known as shadow banking. The complex bank holding companies of today are the best example of hybrid intermediaries, but I argue that financial firms from the "nonbank" space can just as easily evolve into conglomerates with similar organizational structure, thus acquiring the cap...

  18. Hybrid composites

    CSIR Research Space (South Africa)

    Jacob John, Maya

    2009-04-01

    Full Text Available effect was observed for the elongation at break of the hybrid composites. The impact strength of the hybrid composites increased with the addition of glass fibres. The tensile and impact properties of thermoplastic natural rubber reinforced short... panels made from conventional structural materials. Figure 3 illustrates the performance of cellular biocomposite panels against conventional systems used for building and residential construction, namely a pre- cast pre-stressed hollow core concrete...

  19. Ultrashort-Pulse Lasers Treating the Crystalline Lens: Will They Cause Vision-Threatening Cataract? (An American Ophthalmological Society Thesis)

    Science.gov (United States)

    Krueger, Ronald R.; Uy, Harvey; McDonald, Jared; Edwards, Keith

    2012-01-01

    Purpose: To demonstrate that ultrashort-pulse laser treatment in the crystalline lens does not form a focal, progressive, or vision-threatening cataract. Methods: An Nd:vanadate picosecond laser (10 ps) with prototype delivery system was used. Primates: 11 rhesus monkey eyes were prospectively treated at the University of Wisconsin (energy 25–45 μJ/pulse and 2.0–11.3M pulses per lens). Analysis of lens clarity and fundus imaging was assessed postoperatively for up to 4½ years (5 eyes). Humans: 80 presbyopic patients were prospectively treated in one eye at the Asian Eye Institute in the Philippines (energy 10 μJ/pulse and 0.45–1.45M pulses per lens). Analysis of lens clarity, best-corrected visual acuity, and subjective symptoms was performed at 1 month, prior to elective lens extraction. Results: Bubbles were immediately seen, with resolution within the first 24 to 48 hours. Afterwards, the laser pattern could be seen with faint, noncoalescing, pinpoint micro-opacities in both primate and human eyes. In primates, long-term follow-up at 4½ years showed no focal or progressive cataract, except in 2 eyes with preexisting cataract. In humans, 70% reported acceptable or better distance vision and no or mild symptoms. Meanwhile, >70% without sparing (0 and 0.5 mm radius) lost 2 or more lines, and most reported poor or severe vision and symptoms. Conclusions: Focal, progressive, and vision-threatening cataracts can be avoided by lowering the laser energy, avoiding prior cataract, and sparing the center of the lens. PMID:23818739

  20. An inverse and analytic lens design method

    CERN Document Server

    Lu, Yang

    2016-01-01

    Traditional lens design is a numerical and forward process based on ray tracing and aberration theory. This method has limitations because the initial configuration of the lens has to be specified and the aberrations of the lenses have to considered. This paper is an initial attempt to investigate an analytic and inverse lens design method, called Lagrange, to overcome these barriers. Lagrange method tries to build differential equations in terms of the system parameters and the system input and output (object and image). The generalized Snell's law in three dimensional space and the normal of a surface in fundamental differential geometry are applied. Based on the Lagrange method equations for a single surface system are derived which can perfectly image a point object.

  1. 3D printed helical antenna with lens

    KAUST Repository

    Farooqui, Muhammad Fahad

    2016-12-19

    The gain of an antenna can be enhanced through the integration of a lens, however this technique has traditionally been restricted to planar antennas due to fabrication limitations of standard manufacturing processes. Here, with a unique combination of 3D and 2D inkjet printing of dielectric and metallic inks respectively, we demonstrate a Fresnel lens that has been monolithically integrated to a non-planar antenna (helix) for the first time. Antenna measurements show that the integration of a Fresnel lens enhances the gain of a 2-turn helix by around 4.6 dB giving a peak gain of about 12.9 dBi at 8.8 GHz.

  2. Catadioptric aberration correction in cathode lens microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Tromp, R.M. [IBM T.J. Watson Research Center, PO Box 218, Yorktown Heights, NY 10598 (United States); Kamerlingh Onnes Laboratory, Leiden Institute of Physics, Niels Bohrweg 2, 2333 CA Leiden (Netherlands)

    2015-04-15

    In this paper I briefly review the use of electrostatic electron mirrors to correct the aberrations of the cathode lens objective lens in low energy electron microscope (LEEM) and photo electron emission microscope (PEEM) instruments. These catadioptric systems, combining electrostatic lens elements with a reflecting mirror, offer a compact solution, allowing simultaneous and independent correction of both spherical and chromatic aberrations. A comparison with catadioptric systems in light optics informs our understanding of the working principles behind aberration correction with electron mirrors, and may point the way to further improvements in the latter. With additional developments in detector technology, 1 nm spatial resolution in LEEM appears to be within reach. - Highlights: • The use of electron mirrors for aberration correction in LEEM/PEEM is reviewed. • A comparison is made with similar systems in light optics. • Conditions for 1 nm spatial resolution are discussed.

  3. Louvre-Lens : le Louvre autrement

    OpenAIRE

    Audrey Bodéré

    2010-01-01

    ∙ Quels sont les enjeux du projet Louvre-Lens pour le Musée du Louvre ? Par ce projet, le Louvre participe tant à la politique de décentralisation qu’à une volonté de démocratisation culturelle, en allant à la rencontre de nouveaux publics. Mais le projet scientifique et culturel du Louvre-Lens (PSC) précise aussi que l'un des principaux défis est d'oser le « Louvre autrement ». La présentation des collections est donc repensée pour traduire le monde Louvre à Lens. Le lien entre le Louvre Par...

  4. Louvre-Lens : le Louvre autrement

    Directory of Open Access Journals (Sweden)

    Audrey Bodéré

    2010-04-01

    Full Text Available ∙ Quels sont les enjeux du projet Louvre-Lens pour le Musée du Louvre ? Par ce projet, le Louvre participe tant à la politique de décentralisation qu’à une volonté de démocratisation culturelle, en allant à la rencontre de nouveaux publics. Mais le projet scientifique et culturel du Louvre-Lens (PSC précise aussi que l'un des principaux défis est d'oser le « Louvre autrement ». La présentation des collections est donc repensée pour traduire le monde Louvre à Lens. Le lien entre le Louvre Par...

  5. Image watermarking against lens flare effects

    Science.gov (United States)

    Chotikawanid, Piyanart; Amornraksa, Thumrongrat

    2017-02-01

    Lens flare effects in various photo and camera software nowadays can partially or fully damage the watermark information within the watermarked image. We propose in this paper a spatial domain based image watermarking against lens flare effects. The watermark embedding is based on the modification of the saturation color component in HSV color space of a host image. For watermark extraction, a homomorphic filter is used to predict the original embedding component from the watermarked component, and the watermark is blindly recovered by differentiating both components. The watermarked image's quality is evaluated by wPSNR, while the extracted watermark's accuracy is evaluated by NC. The experimental results against various types of lens flare effects from both computer software and mobile application showed that our proposed method outperformed the previous methods.

  6. The Frontier Fields Lens Modeling Comparison Project

    CERN Document Server

    Meneghetti, M; Coe, D; Contini, E; De Lucia, G; Giocoli, C; Acebron, A; Borgani, S; Bradac, M; Diego, J M; Hoag, A; Ishigaki, M; Johnson, T L; Jullo, E; Kawamata, R; Lam, D; Limousin, M; Liesenborgs, J; Oguri, M; Sebesta, K; Sharon, K; Williams, L L R; Zitrin, A

    2016-01-01

    Gravitational lensing by clusters of galaxies offers a powerful probe of their structure and mass distribution. Deriving a lens magnification map for a galaxy cluster is a classic inversion problem and many methods have been developed over the past two decades to solve it. Several research groups have developed techniques independently to map the predominantly dark matter distribution in cluster lenses. While these methods have all provided remarkably high precision mass maps, particularly with exquisite imaging data from the Hubble Space Telescope (HST), the reconstructions themselves have never been directly compared. In this paper, we report the results of comparing various independent lens modeling techniques employed by individual research groups in the community. Here we present for the first time a detailed and robust comparison of methodologies for fidelity, accuracy and precision. For this collaborative exercise, the lens modeling community was provided simulated cluster images -- of two clusters Are...

  7. A High Speed Autofocusing System for Micro System Applications

    Institute of Scientific and Technical Information of China (English)

    Phuchong Sripolsaen; Pradit Mittrapiyanuruk; Pakorn Keawtrakulpong

    2016-01-01

    In this paper, we present a high speed autofocus system for micro system applications and design a look-up-table based autofocusing algorithm for applications when a target object is always visible, e.g., manufacturing parts with alignment fiducials. We perform an evaluation of 24 focus measures to verify that which focus measure is the best for the look-up-table based method. From the evaluation, we find that the Chebyshev moments-based focus measure (CHEB) is the most suitable. Furthermore, we also develop a look-up-table based autofocus system that uses CHEB as the focus measure. In training phase, we offline construct a table from training images of an object that are captured at several lens distances. Each entry of table consists of focus measure computed from image and lens distance. In working phase, given an input image, the algorithm first computes the focus measure and then finds the best match focus measure from the table and looks up the corresponding lens position for moving it into the in-focus position. Our algorithm can perform autofocusing within only 2 steps of lens moving. The experiment shows that the system can perform high speed autofocusing of micro objects.

  8. Photonic crystal based polarization insensitive flat lens

    Science.gov (United States)

    Turduev, M.; Bor, E.; Kurt, H.

    2017-07-01

    The paper proposes a new design of an inhomogeneous artificially created photonic crystal lens structure consisting of annular dielectric rods to efficiently focus both transverse electric and transverse magnetic polarizations of light into the same focal point. The locations of each individual cell that contains the annular dielectric rods are determined according to a nonlinear distribution function. The inner and outer radii of the annular photonic dielectric rods are optimized with respect to the polarization insensitive frequency response of the transmission spectrum of the lens structure. The physical background of the polarization insensitive focusing mechanism is investigated in both spatial and frequency domains. Moreover, polarization independent wavefront transformation/focusing has been explored in detail by investigating the dispersion relation of the structure. Corresponding phase index distribution of the lens is attained for polarization insensitive normalized frequency range of a/λ  =  0.280 and a/λ  =  0.300, where a denotes the lattice constant of the designed structure and λ denotes the wavelength of the incident light. We show the wave transformation performance and focal point movement dynamics for both polarizations of the lens structure by specially adjusting the length of the structure. The 3D finite-difference time domain numerical analysis is also performed to verifiy that the proposed design is able to focus the wave regardless of polarization into approximately the same focal point (difference between focal distances of both polarizations stays below 0.25λ) with an operating bandwidth of 4.30% between 1476 nm and 1541 nm at telecom wavelengths. The main superiorities of the proposed lens structure are being all dielectric and compact, and having flat front and back surfaces, rendering the proposed lens design more practical in the photonic integration process in various applications such as optical switch

  9. Intraocular Lens Calcification; a Clinicopathologic Report

    Directory of Open Access Journals (Sweden)

    Mozhgan Rezaei-Kanavi

    2009-04-01

    Full Text Available

    PURPOSE: To describe the clinical and pathological features of a case of hydrogel intraocular lens (IOL calcification. CASE REPORT: A 48-year-old man underwent explantation of a single-piece hydrophilic acrylic intraocular lens in his left eye because of decreased visual acuity and milky white opalescence of the IOL. The opacified lens was exchanged uneventfully with a hydrophobic acrylic IOL. Gross examination of the explanted IOL disclosed opacification of the optic and haptics. Full-thickness sections of the lens optic were stained with hematoxylin and eosin (H&E, von Kossa and Gram Tworts'. Microscopic examination of the sections revealed fine and diffuse basophilic granular deposits of variable size within the lens optic parallel to the lens curvature but separated from the surface by a moderately clear zone. The deposits were of high calcium content as evident by dark brown staining with von Kossa. Gram Tworts' staining disclosed no microorganisms. CONCLUSION: This report further contributes to the existing literature on hydrogel IOL calcification.

  10. Laser and focused ion beam combined machining for micro dies.

    Science.gov (United States)

    Yoshida, Y; Okazaki, W; Uchida, T

    2012-02-01

    We have developed a laser and focused ion beam (FIB) compound process for press mold dies of a micro lens array (MLA) and a micro needle array (MNA) in a glassy carbon (GC). The press mold die of the MLA was roughly fabricated by UV-YAG laser. After this process, we finished this surface by scanning FIB. As a result, higher accuracy and good roughness of surface profile can be realized. An optical glass is used to confirm the shape of lens. Moreover, we fabricated 6 × 6 through-holes in the GC by the spiral drilling in addition to the focus position movement of the UV laser for press mold die of the MNA. After the FIB process, we were able to make the needle die of surface and hole wall roughness less than 0.9 μm. A silicon rubber is used to confirm the shape of the holes.

  11. Pulse transformer for the AA lithium lens

    CERN Multimedia

    1980-01-01

    The antiprotons emanating from the target were initially focused by a magnetic horn. Later on, a Li-lens was used during operation for the SPS collider, until 1992. A Li-rod (130 mm long, 34 mm in diameter) constituted the secondary of a 1:23 pulse-transformer. The half-sine pulse rose to 1000 kA in 900 microsec. The angular acceptance was 95 mrad. In operation after 1992, for LEAR only, a more modest Li-lens was used (155 mm long, diameter 20 mm, 480 kA, risetime 240 microsec, angular acceptance 75 mrad).

  12. Time resolved thermal lens in edible oils

    Science.gov (United States)

    Albuquerque, T. A. S.; Pedreira, P. R. B.; Medina, A. N.; Pereira, J. R. D.; Bento, A. C.; Baesso, M. L.

    2003-01-01

    In this work time resolved thermal lens spectrometry is applied to investigate the optical properties of the following edible oils: soya, sunflower, canola, and corn oils. The experiments were performed at room temperature using the mode mismatched thermal lens configuration. The results showed that when the time resolved procedure is adopted the technique can be applied to investigate the photosensitivity of edible oils. Soya oil presented a stronger photochemical reaction as compared to the other investigated samples. This observation may be relevant for future studies evaluating edible oils storage conditions and also may contribute to a better understanding of the physical and chemical properties of this important foodstuff.

  13. Fundamentals of concentric lens systems synthesis

    Science.gov (United States)

    Ezhova, Kseniia; Zverev, Victor; Tochilina, Tatiana; Tymoshchuk, Irina

    2016-09-01

    Introduction of coefficients defining the relationship of the radii of curvature of the surfaces of concentric optical systems, allowed the transformation of the obtained analytical relations in a system of two equations with two unknowns. It is shown that the existence of the solution of the system of equations determined by the optical constants of the selected lens material. The results of the analysis of the conditions of the chromatic aberration correction position and the sequence of obtaining of the system equations define the theoretical basis of the engineering method of parametric synthesis of concentric lens systems. Application of the developed method is illustrated by examples of calculation particular systems design build.

  14. Bilateral Pseudoexfoliation Deposits on Intraocular Lens Implants

    Directory of Open Access Journals (Sweden)

    Elena Bonafonte Marquez

    2015-01-01

    Full Text Available We present a rare case of bilateral pseudoexfoliative deposits on both intraocular lens (IOL implants in an 83-year-old woman with no other associated pathology, 5 years after cataract surgery. Pseudoexfoliation syndrome is the most common cause of secondary open-angle glaucoma worldwide and these deposits are usually found on the natural lens. The fact that pseudoexfoliative deposits have been found on IOL implants implies the need for a thorough examination in pseudophakic patients, for it could be the only sign of secondary glaucoma.

  15. Immunochemical analyses of soluble lens proteins in some marine fishes

    Digital Repository Service at National Institute of Oceanography (India)

    Menezes, M.R.

    Soluble eye lens proteins of 10 fishes, belonging to the families Clupeidae, Hemirhamphidae, Lactaridae, Scombridae, Stromatidae, Psettodidae, Bothidae and Soleidae were studied by immunoelectrophoresis using the lens antiserum of Sardinella...

  16. Experimental Contact Lens to Prevent Glaucoma-Induced Blindness

    Science.gov (United States)

    ... Home Page An Experimental Contact Lens to Prevent Glaucoma-Induced Blindness By Sharon Reynolds Posted January 23, 2014 An experimental contact lens design releases a glaucoma medicine at a steady rate for up to ...

  17. Broadband near-field enhancement in the macro-periodic and micro-random structure with a hybridized excitation of propagating Bloch-plasmonic and localized surface-plasmonic modes.

    Science.gov (United States)

    Lu, Haifei; Ren, Xingang; Sha, Wei E I; Ho, Ho-Pui; Choy, Wallace C H

    2015-10-28

    We demonstrate that the silver nanoplate-based macroscopically periodic (macro-periodic) and microscopically random (micro-random) structure has a broadband near-field enhancement as compared to conventional silver gratings. The specific field enhancement in a wide spectral range (from UV to near-infrared) originates from the abundance of localized surface-plasmonic (LSP) modes in the microscopically random distributed silver nanoplates and propagating Bloch-plasmonic (PBP) modes from the macroscopically periodic pattern. The characterization of polarization dependent spectral absorption, surface-enhanced Raman spectroscopy (SERS), as well as theoretical simulation was conducted to comprehensively understand the features of the broadband spectrum and highly concentrated near-field. The reported macro-periodic and micro-random structure may offer a new route for the design of plasmonic systems for photonic and optoelectronic applications.

  18. Phakic Pattern Pseudoexfoliation Material Accumulation on Intraocular Lens Surface

    Directory of Open Access Journals (Sweden)

    Emre Güler

    2014-03-01

    Full Text Available Pseudophakic pseudoexfoliation is the accumulation of pseudoexfoliation material on the intraocular lens. Most of the cases have showed scattered flecks of pseudoexfoliation material on the surface of the intraocular lens. However, the phakic pattern consisting of classic three-zone on the intraocular lens is rarely observed. In this case report, we describe a phakic pattern pseudoexfoliation material on the intraocular lens surface 8 years after cataract extraction. (Turk J Ophthalmol 2014; 44: 156-7

  19. Phakic Pattern Pseudoexfoliation Material Accumulation on Intraocular Lens Surface

    OpenAIRE

    Emre Güler; Aylin Tenlik; Tuba Kara Akyüz

    2014-01-01

    Pseudophakic pseudoexfoliation is the accumulation of pseudoexfoliation material on the intraocular lens. Most of the cases have showed scattered flecks of pseudoexfoliation material on the surface of the intraocular lens. However, the phakic pattern consisting of classic three-zone on the intraocular lens is rarely observed. In this case report, we describe a phakic pattern pseudoexfoliation material on the intraocular lens surface 8 years after cataract extraction. (Turk J Ophthalm...

  20. Lens autofluorescence is not increased at high altitude

    DEFF Research Database (Denmark)

    Kessel, Line; Kofoed, Peter Kristian; Zubieta-Calleja, Gustavo

    2010-01-01

    PURPOSE: To study the relation between ambient environmental ultraviolet radiation exposure and lens fluorescence. METHODS: Non-invasive lens fluorometry measurements were compared in healthy Bolivian and Danish subjects. Background ultraviolet radiation was 4.5 times higher in Bolivia than...... in Denmark. RESULTS: No significant differences in lens fluorescence or transmittance were found between Bolivian and Danish volunteers. CONCLUSION: Age-corrected lens fluorescence and transmittance were comparable for healthy participants living at high altitude near the equator and healthy volunteers...

  1. An Ultrasonic Lens Design Based on Prefractal Structures

    OpenAIRE

    Sergio Castiñeira-Ibáñez; Daniel Tarrazó-Serrano; Constanza Rubio; Pilar Candelas; Antonio Uris

    2016-01-01

    The improvement in focusing capabilities of a set of annular scatterers arranged in a fractal geometry is theoretically quantified in this work by means of the finite element method (FEM). Two different arrangements of rigid rings in water are used in the analysis. Thus, both a Fresnel ultrasonic lens and an arrangement of rigid rings based on Cantor prefractals are analyzed. Results show that the focusing capacity of the modified fractal lens is better than the Fresnel lens. This new lens is...

  2. On the isolation of elemental carbon for micro-molar 14C accelerator mass spectrometry; evaluation of alternative isolation procedures, and accuracy assurance using a hybrid isotopic particulate carbon reference material

    OpenAIRE

    Currie, L A; Kessler,J.D.

    2005-01-01

    International audience; The primary objective of the research reported here has been the development of an hybrid reference material (RM) to serve as a test of accuracy for elemental carbon (EC) isotopic (14C) speciation measurements. Such measurements are critically important for the quantitative apportionment of fossil and biomass sources of ''soot'' (EC), the tracer of fire that has profound effects on health, atmospheric visibility, and climate. Previous studies of 14C-EC measurement qual...

  3. 21 CFR 886.4300 - Intraocular lens guide.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Intraocular lens guide. 886.4300 Section 886.4300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES OPHTHALMIC DEVICES Surgical Devices § 886.4300 Intraocular lens guide. (a) Identification. An intraocular lens guide is a device...

  4. 21 CFR 886.5916 - Rigid gas permeable contact lens.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Rigid gas permeable contact lens. 886.5916 Section... (CONTINUED) MEDICAL DEVICES OPHTHALMIC DEVICES Therapeutic Devices § 886.5916 Rigid gas permeable contact lens. (a) Identification. A rigid gas permeable contact lens is a device intended to be worn...

  5. 21 CFR 800.10 - Contact lens solutions; sterility.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Contact lens solutions; sterility. 800.10 Section...) MEDICAL DEVICES GENERAL Requirements for Specific Medical Devices § 800.10 Contact lens solutions... ophthalmic use, including contact lens solutions, should be sterile. It is further evident that...

  6. Analysis on shift and rotation of intraocular lens after phakic collamer lens implantation

    National Research Council Canada - National Science Library

    Yuan-Yuan Lu; Na Yang; Xue-Dong Li; Jun Kong

    2016-01-01

    .... In 1993, Staar Surgical(A.G. Nidau)introduced a modified intraocular collamer lens(ICL)for the correction of high myopia, which emerged as a safe and effective operation for moderate or high myopia gradually...

  7. Contact lens wear and microbial keratitis.

    Science.gov (United States)

    Ahuja, Markanday

    2002-11-01

    Common types of contact lens are hard, rigid gas-permeable or soft lenses. Most lenses are worn on a daily basis. Cosmetic lenses are worn for non-medical indications. Microbial keratitis, a rare but most significant complication is discussed in this article. Pseudomonas aeruginosa and staphylococci are the most common organisms cause infective keratitis. Fungi and acanthamoeba are also responsible. The causes of increased susceptibility to infection are poor lens hygiene, adhesion of bacteria to lens surface and hypoxia. Preventing measures to be taken while wearing contact lens are discussed in a nutshell. Ocular pain, conjunctival infection, photophobia, epiphora and reduced vision are some of the symptoms of corneal infection. Diagnostic laboratory investigations are to be carried out immediately when a microbial corneal ulcer is suspected. Acanthamoeba can be cultured from corneal scrapes. Immunologically based fluorescein labelling techniques appear to be more sensitive than simple staining. The treatment consists of medical and surgical intervention. Corneal thinning, descemetocele formation and perforation are possible complications.

  8. Testing and inspecting lens by holographic means

    Science.gov (United States)

    Hildebrand, Bernard P.

    1976-01-01

    Processes for the accurate, rapid and inexpensive testing and inspecting of oncave and convex lens surfaces through holographic means requiring no beamsplitters, mirrors or overpower optics, and wherein a hologram formed in accordance with one aspect of the invention contains the entire interferometer and serves as both a master and illuminating source for both concave and said convex surfaces to be so tested.

  9. Lens testing using total internal reflection holography

    Science.gov (United States)

    Hildebrand, Bernard P.

    1976-12-14

    Accurate, rapid and inexpensive testing and inspecting of lens surfaces tugh holographic means requiring no beamsplitters, mirrors or overpower optics, and wherein a hologram formed in accordance with one aspect of the invention contains the entire interferometer and serves as both a master and illuminating source for both concave and convex surfaces to be so tested.

  10. Contact lens rehabilitation following repaired corneal perforations

    Directory of Open Access Journals (Sweden)

    Sreenivas V

    2006-03-01

    Full Text Available Abstract Background Visual outcome following repair of post-traumatic corneal perforation may not be optimal due to presence of irregular keratometric astigmatism. We performed a study to evaluate and compare rigid gas permeable contact lens and spectacles in visual rehabilitation following perforating corneal injuries. Method Eyes that had undergone repair for corneal perforating injuries with or without lens aspiration were fitted rigid gas permeable contact lenses. The fitting pattern and the improvement in visual acuity by contact lens over spectacle correction were noted. Results Forty eyes of 40 patients that had undergone surgical repair of posttraumatic corneal perforations were fitted rigid gas permeable contact lenses for visual rehabilitation. Twenty-four eyes (60% required aphakic contact lenses. The best corrected visual acuity (BCVA of ≥ 6/18 in the snellen's acuity chart was seen in 10 (25% eyes with spectacle correction and 37 (92.5% eyes with the use of contact lens (p Conclusion Rigid gas permeable contact lenses are better means of rehabilitation in eyes that have an irregular cornea due to scars caused by perforating corneal injuries.

  11. Magnifying perfect lens with positive refraction

    CERN Document Server

    Tyc, Tomas

    2010-01-01

    We propose a device with a positive isotropic refractive index that creates a magnified perfect real image of an optically homogeneous three-dimensional region of space within geometrical optics. Its key ingredient is a new refractive index profile that can work as a perfect lens on its own, having a very moderate index range.

  12. Solar powered desalination system using Fresnel lens

    Science.gov (United States)

    Sales, M. T. B. F.

    2016-11-01

    The Philippines is surrounded by coastal areas and these areas can be a potential source for potable water. This study aims to design and construct a solar powered desalination system using Fresnel lens. The experimental study was conducted using polluted salt water for the sample and desalination was carried out using the designed system. The desalination system was composed of the solar concentrator, solar still and the condenser system. The Fresnel lens was made of acrylic plastic and was an effective solar concentrator. Solar stills made of dark colored glass bottles were effective in absorbing the solar energy. The condenser system made of polybutylene and polystyrene were effective in condensing the vapor at ambient temperature. The shortest time of vaporization of the salt water was at 293 sec and the optimum angle of position of the lens was 36.42°. The amount of condensate collected was directly proportional to the amount of salt water in the solar still. The highest mean efficiency of the designed set-up was 34.82%. The water produced by the solar powered desalination system using Fresnel lens passed the standards set by WHO (World Health Organization) for drinking water.

  13. Intraocular lens in a fighter aircraft pilot.

    OpenAIRE

    Loewenstein, A; Geyer, O; Biger, Y; Bracha, R; Shochat, I; Lazar, M.

    1991-01-01

    A pseudophakic pilot of the Israeli air force flying an F-15 (Eagle) aircraft was followed up for three years. He experienced about 100 flying hours, 5% of the time under high g stress. The intraocular lens did not dislocate and no complications were observed. It seems that flying high performance fighter aircraft is not contraindicated in pseudophakic pilots.

  14. High Accuracy Dual Lens Transmittance Measurements

    Science.gov (United States)

    2007-08-01

    measurement of lens transmission,” Metrologia 37, 603–605 (2000). 3. B. Munro, “Quantum information processing with light and its requirement for detectors...5. N. P. Fox, “Trap detectors and their properties,” Metrologia 28, 197–202 (1991). 5402 APPLIED OPTICS Vol. 46, No. 22 1 August 2007 6. S. L

  15. Report on design rules of μ-tools for hybrid tooling

    DEFF Research Database (Denmark)

    Esmoris, Jose Ignacio; Azcarate, S.; Tosello, Guido;

    2011-01-01

    tool-making procedures for micro-moulds and inserts manufacture. The innovative approach promoted by COTECH is the use of novel hybrid processes for micro tooling. This approach has been demonstrated to be able to provide optimal performance and enable the manufacture of micro-tools rapidly and cost...

  16. High Dk piggyback contact lens system for contact lens-intolerant keratoconus patients

    OpenAIRE

    Tomris Sengor; Sevda Aydin Kurna; Suat Aki; et al

    2011-01-01

    Tomris Sengor, Sevda Aydin Kurna, Suat Aki, Yelda ÖzkurtFatih Sultan Mehmet Training and Research Hospital, Istanbul, TurkeyBackground: The aim of the study was to examine the clinical success of high Dk (oxygen permeability) piggyback contact lens (PBCL) systems for the correction of contact lens intolerant keratoconus patients.Methods: Sixteen patients (29 eyes) who were not able to wear gas-permeable rigid lenses were included in this study. Hyper Dk silicone hydrogel (oxygen tran...

  17. Minus Piggyback Lens Overlaying ReSTOR® Multifocal Lens in High Myopia

    Directory of Open Access Journals (Sweden)

    Isha Gupta

    2013-06-01

    Full Text Available Background: We report the case of a 40-year-old female patient treated with implantation of the Acrysof® IQ ReSTOR® lens (Alcon, Fort Worth, Tex., USA with overlaying Acrysof EXpand® minus piggyback lens (Alcon. Methods: The patient had high myopia and was diagnosed with presbyopia and bilateral posterior subcapsular cataract. She desired to be spectacle-free and opted to undergo bilateral placement of the ReSTOR multifocal lens. The necessary intraocular lens (IOL power was +3.5 in the right eye and +4.0 in the left eye, though the range of commercially available ReSTOR lenses is +6.0 to +34.0 D. In order to achieve emmetropia in this case of high myopia, it was determined that an EXpand minus piggyback lens would be necessary. Results: Implantation of the ReSTOR lens with overlaying EXpand minus piggyback lens was performed successfully and without complication. At 5 months postoperatively, the patient had 20/20 uncorrected visual acuity in both eyes. She reported a high level of satisfaction and was able to return to her daily activities including reading and driving without spectacles. Conclusion: We report successful primary implantation of AcrySof EXpand minus piggyback lenses overlying the AcrySof IQ ReSTOR lens in a patient with high myopia. Long-term follow-up and further evaluation is necessary to establish piggyback IOL implantation with multifocal IOL as an accepted treatment for high myopia with presbyopia.

  18. Preventive role of lens antioxidant defense mechanism against riboflavin-mediated sunlight damaging of lens crystallins.

    Science.gov (United States)

    Anbaraki, Afrooz; Khoshaman, Kazem; Ghasemi, Younes; Yousefi, Reza

    2016-10-01

    The main components of sunlight reaching the eye lens are UVA and visible light exerting their photo-damaging effects indirectly by the aid of endogenous photosensitizer molecules such as riboflavin (RF). In this study, lens proteins solutions were incubated with RF and exposed to the sunlight. Then, gel mobility shift analysis and different spectroscopic assessments were applied to examine the structural damaging effects of solar radiation on these proteins. Exposure of lens proteins to direct sunlight, in the presence of RF, leads to marked structural crosslinking, oligomerization and proteolytic instability. These structural damages were also accompanied with reduction in the emission fluorescence of Trp and Tyr and appearance of a new absorption peak between 300 and 400nm which can be related to formation of new chromophores. Also, photo-oxidation of lens crystallins increases their oligomeric size distribution as examined by dynamic light scattering analysis. The above mentioned structural insults, as potential sources of sunlight-induced senile cataract and blindness, were significantly attenuated in the presence of ascorbic acid and glutathione which are two important components of lens antioxidant defense system. Therefore, the powerful antioxidant defense mechanism of eye lens is an important barrier against molecular photo-damaging effects of solar radiations during the life span. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Analysis of fiber lens with gradient index based on thin lens equivalence

    Institute of Scientific and Technical Information of China (English)

    ZHANG Rui-feng; GE Chun-feng; LI Shi-chen

    2006-01-01

    Theoretical analysis of the fiber-lens TEC (Thermally Expended Core) /Coreless/GRIN (Graded-Index) based on thin lens equivalence is presented in this paper.On condition that the TEC part adjusts the waist radius of an incident Gaussian beam,that the coreless part controlls the space between the beam waist and the thin lens,and that the GRIN part acts as the thin lens with its focal length determined by fiber index distribution parameter g,the analytic expressions of the waist spot size and the working distance of the output Gaussian beam are derived,and the influence of the coreless fiber and the length of the GRIN fiber upon the fiber-lens parameter is discussed based on the numerical simulation results.It is concluded that,if a GRIN style fiber-lens is used as a collimator,the maximum of the spot waist can be up to 80 μm and the divergence angle of single-mode optical fiber can be reduced by 8 times.If it is applied to a MEMS device, the maximum working distance can be up to 3 mm.

  20. Micro club

    CERN Multimedia

    Micro club

    2014-01-01

    Opération NEMO   Pour finir en beauté les activités spéciales que le CMC a réalisé pendant cette année 2014, pour commémorer le 60ème anniversaire du CERN, et le 30ème du Micro Club, l’ Opération NEMO aura cette année un caractère très particulier. Nous allons proposer 6 fabricants de premier ordre qui offriront chacun deux ou trois produits à des prix exceptionnels. L’opération débute le lundi 17 novembre 2014. Elle se poursuivra  jusqu’au samedi 6 décembre inclus. Les délais de livraison seront de deux à trois semaines, selon les fabricants. Donc les commandes faites la dernière semaine, du 1 au 6 décembre, risquent d’arriver qu'au début du mois de janvier 2015. Liste de fabricants part...

  1. Micro club

    CERN Multimedia

    Micro Club

    2014-01-01

    Jeudi 18 septembre 2014 à 18h30 au Bât. 567 R-029 Le CERN MICRO CLUB organise un Atelier sur la sécurité informatique. La Cyber-sécurité : Ce qui se passe vraiment, comment ne pas en être victime ! Orateur : Sebastian Lopienski Adjoint au Computer Security Officer du Département IT. Sujet : Cet exposé vous présentera les modes de sécurité actuels et les problèmes touchants les applications logicielles des ordinateurs, les réseaux ainsi que leurs utilisateurs. Cela inclus des informations sur les nouveaux types de vulnérabilité, les vecteurs d'attaque récents et une vue d'ensemble sur le monde de la cyber-sécurité en 2014. Biographie : Sebastian Lopienski travaille au CERN depuis 2001. Il est actuellement adjoint au Computer Security Officer et s'occupe de la protection de...

  2. Liquid bridge as a tunable-focus cylindrical liquid lens

    Science.gov (United States)

    Chen, H.; Tabatabaei, N.; Amirfazli, A.

    2017-01-01

    We proposed a method to create a tunable-focus cylindrical liquid lens using a liquid bridge between two narrow surfaces. Due to the surface edge effect, the interface of the liquid bridge (on the long side) was shown to be able to serve as a tunable-focus cylindrical liquid lens. The working distance of the lens can be adjusted by changing either or both of the height of the bridge (H) and the volume of the liquid (V). By varying H and V, the lens can serve as either diverging or converging lens, with a minimum working distance of 2.11 mm.

  3. Gram negative bacteria and contact lens induced acute red eye

    Directory of Open Access Journals (Sweden)

    Sankaridurg Padmaja

    1996-01-01

    Full Text Available Two patients using hydrogel contact lenses on a daily wear schedule slept overnight with the lenses and woke up with a Contact Lens Induced Acute Red Eye (CLARE. The contact lenses recovered aseptically at the time of the event grew significant colonies of Pseudomonas aeruginosa and Aeromonas hydrophila in patient A and Pseudomonas aeruginosa and Serratia liquefaciens from patient B. Similar organisams from the contact lenses were recovered from the lens case and lens care solutions of patient B. In both the patients the condition resolved on discontinuation of lens wear. Patient compliance as a requirement for successful contact lens wear is highlighted with the illustration of these cases.

  4. Hybrid Control Strategy for Photovoltaic system Connected to Micro-grid%微网中光伏系统的并网复合控制策略研究

    Institute of Scientific and Technical Information of China (English)

    张丽; 岳建房; 徐玉琴

    2011-01-01

    In order to meet the needs of micro-gid operation, this paper proposes a control strategy which combines minimum beat control with repetitive control. This strategy can he applied to the control of Photovoltaic grid inverter in micro-gid system, whereby the repetitive control can restrain the periodic disturbance of the load and power grid, and evidently reduce the total harmonic distortion of the grid-connected current, while the minimum beat control can improve the dynamic response speed of the system. Finally, modeling on Matlab/Simulink, the simulation results showed that the proposed control strategy is correct and effective, as well as applicable to other types of inverter power supply in micro-grid.%为了更好的满足微网运行的需要,提出一种重复控制跟最少拍控制相结合的复合控制策略。将这种策略应用于微网中光伏逆变器的联网运行控制,重复控制保证了系统具有高稳态精度和低谐波畸变率,最少拍控制保证了系统的动态响应速度。通过MATLAB软件建立模型进行仿真,证明了该控制法案的正确性和有效性,同时这种复合控制的思想也适用于微网中的其它逆变型电源。

  5. Hybrid Filter Membrane

    Science.gov (United States)

    Laicer, Castro; Rasimick, Brian; Green, Zachary

    2012-01-01

    Cabin environmental control is an important issue for a successful Moon mission. Due to the unique environment of the Moon, lunar dust control is one of the main problems that significantly diminishes the air quality inside spacecraft cabins. Therefore, this innovation was motivated by NASA s need to minimize the negative health impact that air-suspended lunar dust particles have on astronauts in spacecraft cabins. It is based on fabrication of a hybrid filter comprising nanofiber nonwoven layers coated on porous polymer membranes with uniform cylindrical pores. This design results in a high-efficiency gas particulate filter with low pressure drop and the ability to be easily regenerated to restore filtration performance. A hybrid filter was developed consisting of a porous membrane with uniform, micron-sized, cylindrical pore channels coated with a thin nanofiber layer. Compared to conventional filter media such as a high-efficiency particulate air (HEPA) filter, this filter is designed to provide high particle efficiency, low pressure drop, and the ability to be regenerated. These membranes have well-defined micron-sized pores and can be used independently as air filters with discreet particle size cut-off, or coated with nanofiber layers for filtration of ultrafine nanoscale particles. The filter consists of a thin design intended to facilitate filter regeneration by localized air pulsing. The two main features of this invention are the concept of combining a micro-engineered straight-pore membrane with nanofibers. The micro-engineered straight pore membrane can be prepared with extremely high precision. Because the resulting membrane pores are straight and not tortuous like those found in conventional filters, the pressure drop across the filter is significantly reduced. The nanofiber layer is applied as a very thin coating to enhance filtration efficiency for fine nanoscale particles. Additionally, the thin nanofiber coating is designed to promote capture of

  6. Acid phosphatase and lipid peroxidation in human cataractous lens epithelium

    Directory of Open Access Journals (Sweden)

    Vasavada Abhay

    1993-01-01

    Full Text Available The anterior lens epithelial cells undergo a variety of degenerative and proliferative changes during cataract formation. Acid phosphatase is primarily responsible for tissue regeneration and tissue repair. The lipid hydroperoxides that are obtained by lipid peroxidation of polysaturated or unsaturated fatty acids bring about deterioration of biological membranes at cellular and tissue levels. Acid phosphatase and lipid peroxidation activities were studied on the lens epithelial cells of nuclear cataract, posterior subcapsular cataract, mature cataract, and mixed cataract. Of these, mature cataractous lens epithelium showed maximum activity for acid phosphatase (516.83 moles of p-nitrophenol released/g lens epithelium and maximum levels of lipid peroxidation (86.29 O.D./min/g lens epithelium. In contrast, mixed cataractous lens epithelium showed minimum activity of acid phosphatase (222.61 moles of p-nitrophenol released/g lens epithelium and minimum levels of lipid peroxidation (54.23 O.D./min/g lens epithelium. From our study, we correlated the maximum activity of acid phosphatase in mature cataractous lens epithelium with the increased areas of superimposed cells associated with the formation of mature cataract. Likewise, the maximum levels of lipid peroxidation in mature cataractous lens epithelium was correlated with increased permeability of the plasma membrane. Conversely, the minimum levels of lipid peroxidation in mixed cataractous lens epithelium makes us presume that factors other than lipid peroxidation may also account for the formation of mixed type of cataract.

  7. Hypoplastic basement membrane of the lens anlage in the inheritable lens aplastic mouse (lap mouse).

    Science.gov (United States)

    Aso, S; Baba, R; Noda, S; Ikuno, S; Fujita, M

    2000-04-01

    Adult homozygous lap mice show various eye abnormalities such as aphakia, retinal disorganization, and dysplasia of the cornea and anterior chamber. In the fetal eye of a homozygous lap mouse, the lens placode appears to develop normally. However, the lens vesicle develops abnormally to form a mass of cells without a cavity, and the mass vanishes soon afterward. Apoptotic cell death is associated with the disappearance of the lens anlage. We examined the basement membranes of the lens anlage of this mutant by immunohistochemical methods under light microscopy using antibodies against basement membrane components of the lens anlage, type IV collagen, fibronectin, laminin, heparan sulfate proteoglycan, and entactin and by transmission electron microscopy. Immunohistochemistry showed the distribution and intensity of antibody binding to the lens anlage to be almost the same for each these antibodies regardless of the stage of gestation or whether the anlagen were from normal BALB/c or lap mice. Thus, positive continuous reactions were observed around the exterior region of the lens anlage from day 10 of gestation for type IV collagen, fibronectin, laminin, heparan sulfate proteoglycan antibodies, and at least from day 11of gestation for entactin antibody. The basement membrane lamina densa of both normal and lap mice was shown by electron microscopy to be discontinuous at days 10 and 10.5 of gestation. However, by day 11 the lamina densa was continuous in the lens anlagen of normal mice but still discontinuous in the lap mice. By day 12 of gestation, the lamina densa had thickened markedly in normal mice, whereas in lap mice it remained discontinuous and its thinness indicated hypoplasia. These results indicate that, while all basement components examined are produced and deposited in the normal region of the lens anlage in the lap mouse, the basement membrane is, for some reason, imperfectly formed. The time at which hypoplasia of the basement membrane was observed

  8. Fast frame rate rodent cardiac x-ray imaging using scintillator lens coupled to CMOS camera

    Science.gov (United States)

    Swathi Lakshmi, B.; Sai Varsha, M. K. N.; Kumar, N. Ashwin; Dixit, Madhulika; Krishnamurthi, Ganapathy

    2017-03-01

    Micro-Computed Tomography (MCT) systems for small animal imaging plays a critical role for monitoring disease progression and therapy evaluation. In this work, an in-house built micro-CT system equipped with a X-ray scintillator lens coupled to a commercial CMOS camera was used to test the feasibility of its application to Digital Subtraction Angiography (DSA). Literature has reported such studies being done with clinical X-ray tubes that can be pulsed rapidly or with rotating gantry systems, thus increasing the cost and infrastructural requirements.The feasibility of DSA was evaluated by injected Iodinated contrast agent (ICA) through the tail vein of a mouse. Projection images of the heart were acquired pre and post contrast using the high frame rate X-ray detector and processing done to visualize transit of ICA through the heart.

  9. Lightweight autoclavable wide-angle contact lens for vitreous surgery.

    Science.gov (United States)

    Chalam, K V; Gupta, Shailesh K; Agarwal, Swati

    2007-01-01

    The authors describe an autoclavable, self-stabilizing, lightweight wide-angle contact lens for vitrectomy. The lens has two optical pieces with perforated plastic casing to sustain a high temperature (150 degrees C) for autoclaving. The lens has a 106 degrees static and 127 degrees dynamic field of view. The footplates and reduced weight (2.4 grams) due to the plastic casing allow self-stabilization of the lens. The open lens design.with high temperature resistant plastic prevents fogging during autoclaving and surgery. The autoclavable, self-stabilizing, lightweight wide-angle contact lens allows visualization of the peripheral retina during surgery and faster sterilization by autoclaving between surgeries without the disadvantage of lens fogging.

  10. Method and apparatus for sputtering with a plasma lens

    Energy Technology Data Exchange (ETDEWEB)

    Anders, Andre

    2016-09-27

    A plasma lens for enhancing the quality and rate of sputter deposition onto a substrate is described herein. The plasma lens serves to focus positively charged ions onto the substrate while deflecting negatively charged ions, while at the same time due to the line of sight positioning of the lens, allowing for free passage of neutrals from the target to the substrate. The lens itself is formed of a wound coil of multiple turns, inside of which are deposed spaced lens electrodes which are electrically paired to impress an E field overtop the B field generated by the coil, the potential applied to the electrodes increasing from end to end towards the center of the lens, where the applied voltage is set to a high potential at the center electrodes as to produce a potential minimum on the axis of the lens.

  11. Pars Plana Vitrectomy in Treatment of Lens Injury

    Directory of Open Access Journals (Sweden)

    Remzi Avcı

    2013-01-01

    Full Text Available Lens injury due to traumas may present as loss of capsule integrity, cataract, lens subluxation, or lens luxation. In addition, lens subluxation and lens luxation may occur in pseudophakic patients due to trauma. Clear corneal, scleral or sclero-corneal phacoemulsification surgery, pars plana vitrectomy, pars plana vitrectomy with phaco-fragmentation, or pars plana vitrectomy with removal through corneal incision techniques are used in the treatment of lens injury due to traumas. Intraocular lens can be implanted in the bag, sulcus, or anterior chamber during the surgery. Depending on the circumstances, scleral fixated intraocular lenses or iris-claw lenses may also be preferred. Rehabilitation of such patients is not of a great concern today, with the advanced level of vitreoretinal surgery and cataract surgery techniques and with the current state of technology. (Turk J Ophthalmol 2013; 43: 51-4

  12. System and Method for Null-Lens Wavefront Sensing

    Science.gov (United States)

    Hill, Peter C. (Inventor); Thompson, Patrick L. (Inventor); Aronstein, David L. (Inventor); Bolcar, Matthew R. (Inventor); Smith, Jeffrey S. (Inventor)

    2015-01-01

    A method of measuring aberrations in a null-lens including assembly and alignment aberrations. The null-lens may be used for measuring aberrations in an aspheric optic with the null-lens. Light propagates from the aspheric optic location through the null-lens, while sweeping a detector through the null-lens focal plane. Image data being is collected at locations about said focal plane. Light is simulated propagating to the collection locations for each collected image. Null-lens aberrations may extracted, e.g., applying image-based wavefront-sensing to collected images and simulation results. The null-lens aberrations improve accuracy in measuring aspheric optic aberrations.

  13. The study about forming high-precision optical lens minimalized sinuous error structures for designed surface

    Science.gov (United States)

    Katahira, Yu; Fukuta, Masahiko; Katsuki, Masahide; Momochi, Takeshi; Yamamoto, Yoshihiro

    2016-09-01

    Recently, it has been required to improve qualities of aspherical lenses mounted on camera units. Optical lenses in highvolume production generally are applied with molding process using cemented carbide or Ni-P coated steel, which can be selected from lens material such as glass and plastic. Additionally it can be obtained high quality of the cut or ground surface on mold due to developments of different mold product technologies. As results, it can be less than 100nmPV as form-error and 1nmRa as surface roughness in molds. Furthermore it comes to need higher quality, not only formerror( PV) and surface roughness(Ra) but also other surface characteristics. For instance, it can be caused distorted shapes at imaging by middle spatial frequency undulations on the lens surface. In this study, we made focus on several types of sinuous structures, which can be classified into form errors for designed surface and deteriorate optical system performances. And it was obtained mold product processes minimalizing undulations on the surface. In the report, it was mentioned about the analyzing process by using PSD so as to evaluate micro undulations on the machined surface quantitatively. In addition, it was mentioned that the grinding process with circumferential velocity control was effective for large aperture lenses fabrication and could minimalize undulations appeared on outer area of the machined surface, and mentioned about the optical glass lens molding process by using the high precision press machine.

  14. Effects of hydrofluoric acid and anodised micro and micro/nano surface implants on early osseointegration in rats.

    Science.gov (United States)

    Li, Yongfeng; Gao, Yuan; Shao, Bo; Xiao, Jianrui; Hu, Kaijin; Kong, Liang

    2012-12-01

    Our aim was to evaluate the effects of hydrofluoric acid and anodised micro and micro/nano surface implants on bony ingrowth in the earliest stage of implantation in rats. Sixty cylindrical screwed titanium alloy implants with machined, micro, and hierarchical hybrid micro/nano surfaces (n=20 in each group) were inserted into the distal femurs of 30 female Sprague-Dawley rats. In vivo microcomputed tomography (micro CT) was used to assess microarchitectural changes in the bone around the implants 2 weeks after implantation. All the animals were then killed and the femurs with implants harvested for histological analysis and pull-out testing. Micro CT analysis showed that the trabecular thickness and the bone:volume ratio (bone volume:total volume) (BV:TV) increased significantly in the micro/nano group compared with the other two groups, while the trabecular separation decreased significantly in the micro/nano group compared with the machined group. The mean (SD) bone-implant contacts (%) were 38.94 (9.48), 41.67 (8.71), and 51.49 (12.49) in the machined, micro, and micro/nano groups, respectively. The maximum pull-out forces (N) were 64.95 (6.11), 71.45 (7.15), and 81.90 (13.1), respectively. Both bone-implant contacts and maximum pull-out forces were significantly higher in the micro/nano group, but there was no significant difference between the micro group and the machined group. These data indicate that the hierarchical hybrid micro/nano surface of the implant can promote osseointegration in the earliest stage of implantation, and may be a promising option for further clinical use.

  15. Multilayer Laue Lens Growth at NSLS-II

    Energy Technology Data Exchange (ETDEWEB)

    Conley R.; Bouet, N.; Lauer, K.; Carlucci-Dayton, M.; Biancarosa, J.; Boas, L.; Drannbauer, J.; Feraca, J.; Rosenbaum, L.

    2012-08-15

    The new NSLS-II deposition laboratory has been commissioned to include a variety of thin-film characterization equipment and a next-generation deposition system. The primary goal for this effort is R&D on the multilayer Laue lens (MLL), which is a new type of x-ray optic with the potential for an unprecedented level of x-ray nano-focusing. This unique deposition system contains many design features in order to facilitate growth of combined depth-graded and laterally graded multilayers with precise thickness control over many thousands of layers, providing total film growth in one run of up to 100 {micro}m thick or greater. A precision in-vacuum linear motor servo system raster scans a substrate over an array of magnetrons with shaped apertures at well-defined velocities to affect a multilayer coating. The design, commissioning, and performance metrics of the NSLS-II deposition system will be discussed. Latest growth results of both MLL and reflective multilayers in this machine will be presented.

  16. A polycarbonate ophthalmic-prescription lens series.

    Science.gov (United States)

    Davis, J K

    1978-08-01

    Improvements in polycarbonate material, production techniques, and scratch-resistant coatings, combined with a process-oriented design, have resulted in a precision lens series. Surface quality is comparable to that of untreated glass ophthalmic lenses. The repeatability of the process results in closely controlled axial power and off-axis performance. For most lens prescriptions, the ANSI Z80.1 optical-center specifications for prescription accuracy are maintained through a total field of view of 40 deg for an 8-mm range of center-of-rotation distances. Off-axis astigmatism is controlled for near-point seeing. The lenses are both lighter and thinner than those of crown glass. A scratch-resistant coating reduces the reflections normally associated with high-index (1.586) materials. Impact resistance exceeds that required by ANSI Z80.7 and is many times that required by ANSI Z80.1.

  17. A Tribute to Dr. Willy Lens

    Directory of Open Access Journals (Sweden)

    Maarten Vansteenkiste

    2016-07-01

    Full Text Available Dr. Willy Lens, born on December 10th, 1943, passed away on August 29th, 2014. With his passing, the motivation community has lost a seminal member, a mentor, and a friend. Dr. Lens – a Fellow of the Association for Psychological Science and Founding Fellow of the American Educational Research Association – made fundamental contributions to the study of motivation both through his own work and through his caring and thoughtful mentorship of a large community of scholars. With this tribute, we want to honor Dr. Willy Lens’ significance to psychology and education as well as his positive influence, both personally and professionally, on the lives of dozens of scholars. With his contagious enthusiasm and caring mentorship, Willy was an example for our academic community and with this tribute we express our gratitude for the privilege to have collaborated with him.

  18. Understanding Science Through the Computational Lens

    Institute of Scientific and Technical Information of China (English)

    Richard M. Karp

    2011-01-01

    This article explores the changing nature of the interaction between computer science and the natural and social sciences.After briefly tracing the history of scientific computation,the article presents the concept of computational lens,a metaphor for a new relationship that is emerging between the world of computation and the world of the sciences.Our main thesis is that,in many scientific fields,the processes being studied can be viewed as computational in nature,in the sense that the processes perform dynamic transformations on information represented as digital data.Viewing natural or engineered systems through the lens of their computational requirements or capabilities provides new insights and ways of thinking.A number of examples are discussed in support of this thesis.The examples are from various fields,including quantum computing,statistical physics,the World Wide Web and the Internet,mathematics,and computational molecular biology.

  19. Hyperbolic metamaterial lens with hydrodynamic nonlocal response.

    Science.gov (United States)

    Yan, Wei; Mortensen, N Asger; Wubs, Martijn

    2013-06-17

    We investigate the effects of hydrodynamic nonlocal response in hyperbolic metamaterials (HMMs), focusing on the experimentally realizable parameter regime where unit cells are much smaller than an optical wavelength but much larger than the wavelengths of the longitudinal pressure waves of the free-electron plasma in the metal constituents. We derive the nonlocal corrections to the effective material parameters analytically, and illustrate the noticeable nonlocal effects on the dispersion curves numerically. As an application, we find that the focusing characteristics of a HMM lens in the local-response approximation and in the hydrodynamic Drude model can differ considerably. In particular, the optimal frequency for imaging in the nonlocal theory is blueshifted with respect to that in the local theory. Thus, to detect whether nonlocal response is at work in a hyperbolic metamaterial, we propose to measure the near-field distribution of a hyperbolic metamaterial lens.

  20. A Lens Mapping Algorithm for Weak Lensing

    CERN Document Server

    Saini, T D; Saini, Tarun Deep; Raychaudhury, Somak

    2001-01-01

    We develop an algorithm for the reconstruction of the two-dimensional massdistribution of a cluster of galaxies from the observable distortion ofbackground galaxies. From the measured reduced shear gamma_i/(1-kappa) the lensmapping is directly obtained, from which a mass distribution is derived. Thisis unlike other methods where the convergence (kappa) is first obtained. Weshow that this method works best for sub-critical lenses but can be applied toa critical lens away from the critical lines. For finite fields the usualmass-sheet degeneracy is shown to exist in this method as well. We suggest aniterative scheme to remove the mass-sheet degeneracy for the case of asub-critical lens, in the absence of a substantial external shear. The sametechnique can be used with additional information for the case of a criticallens as well. A scheme to reduce the effects of noise is also suggested.

  1. Fibrosis in the lens. Sprouty regulation of TGFβ-signaling prevents lens EMT leading to cataract.

    Science.gov (United States)

    Lovicu, F J; Shin, E H; McAvoy, J W

    2016-01-01

    Cataract is a common age-related condition that is caused by progressive clouding of the normally clear lens. Cataract can be effectively treated by surgery; however, like any surgery, there can be complications and the development of a secondary cataract, known as posterior capsule opacification (PCO), is the most common. PCO is caused by aberrant growth of lens epithelial cells that are left behind in the capsular bag after surgical removal of the fiber mass. An epithelial-to-mesenchymal transition (EMT) is central to fibrotic PCO and forms of fibrotic cataract, including anterior/posterior polar cataracts. Transforming growth factor β (TGFβ) has been shown to induce lens EMT and consequently research has focused on identifying ways of blocking its action. Intriguingly, recent studies in animal models have shown that EMT and cataract developed when a class of negative-feedback regulators, Sprouty (Spry)1 and Spry2, were conditionally deleted from the lens. Members of the Spry family act as general antagonists of the receptor tyrosine kinase (RTK)-mediated MAPK signaling pathway that is involved in many physiological and developmental processes. As the ERK/MAPK signaling pathway is a well established target of Spry proteins, and overexpression of Spry can block aberrant TGFβ-Smad signaling responsible for EMT and anterior subcapsular cataract, this indicates a role for the ERK/MAPK pathway in TGFβ-induced EMT. Given this and other supporting evidence, a case is made for focusing on RTK antagonists, such as Spry, for cataract prevention. In addition, and looking to the future, this review also looks at possibilities for supplanting EMT with normal fiber differentiation and thereby promoting lens regenerative processes after cataract surgery. Whilst it is now known that the epithelial to fiber differentiation process is driven by FGF, little is known about factors that coordinate the precise assembly of fibers into a functional lens. However, recent research

  2. A stereoscopic lens for digital cinema cameras

    Science.gov (United States)

    Lipton, Lenny; Rupkalvis, John

    2015-03-01

    Live-action stereoscopic feature films are, for the most part, produced using a costly post-production process to convert planar cinematography into stereo-pair images and are only occasionally shot stereoscopically using bulky dual-cameras that are adaptations of the Ramsdell rig. The stereoscopic lens design described here might very well encourage more live-action image capture because it uses standard digital cinema cameras and workflow to save time and money.

  3. Gravitational Lens: Deep Space Probe Design

    Science.gov (United States)

    2012-03-01

    List of Abbreviations Abbreviation Page FSM Focal Space Mission . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 CMB Cosmic Microwave...concert with the sun’s gravitational lens to image nearby solar systems and/or other pertinent astronomical objects, e.g. the Cosmic Microwave Background...CMB) radiation. 1.2 Thesis Objective In Deep Space Flight and Communications Claudio Maccone uses the mass, radius , mean density, and Schwarzschild

  4. Rose-K contact lens for keratoconus

    Directory of Open Access Journals (Sweden)

    Jain Arun

    2007-01-01

    Full Text Available Aim: To report clinical experience and the comparative value of axial and instantaneous topography data in fitting Rose-K design contact lenses in moderate and severe keratoconus. Materials and Methods: Thirty-eight eyes (of 23 patients with keratoconus were fitted with Rose-K design contact lenses and followed up for at least six months or more. Visual acuity with habitual vision correction available was measured. Axial and instantaneous topography maps for each eye were recorded. Contact lens wear comfort was graded on a ten point rating scale every three months. Results: Fourteen (100% moderate keratoconus eyes (average Sim K 48.61 ± 1.24D and 23 of 24 (96% of severe keratoconus eyes (average Sim K 60.88 ± 5.31D were successfully fitted with the Rose-K lenses. Final fit contact lenses in severe keratoconus had statistically significant steeper base curves compared to average axial corneal curvature than in moderate keratoconus eyes. Average simulated corneal curvature on axial maps predicted final fit contact lens base curves significantly better than on instantaneous maps. Thirty-three of the 37 eyes fitted with contact lenses maintained wear comfort over average follow up period of 13 ± 3.5 months. Conclusions: Rose-K design rigid contact lenses are successful in visually rehabilitating 100% of moderate and 96% of severe keratoconus eyes. Most patients (90% maintained contact lens wear comfort. Corneal curvature on axial maps is a better predictive of base curve of final fit contact lens.

  5. Comparison and Calibration of Mobile Phone Fisheye Lens and Regular Fisheye Lens via Equidistant Model

    Directory of Open Access Journals (Sweden)

    Cumhur Sahin

    2016-01-01

    Full Text Available Nowadays, mobile phones are more than a device that can only satisfy the communication need between people. In addition to providing ease to human lives with various applications, lens kits that can be integrated to mobile phones have recently been introduced. Fisheye lenses that are compliant with mobile phones are one of these new types of equipment. Since fisheye lenses integrated with mobile phones are lightweight and easy to use, they are advantageous. In addition to this advantage, whether fisheye lens and mobile phone combination can be used in a photogrammetric way is experimented, and if so, what will be the result. The main purpose of this study is to test fisheye lens equipment used with mobile phones. In this study, standard calibration of “Olloclip 3 in one” fisheye lens used with iPhone 4S mobile phone and “Nikon FC-E9” fisheye lens used with Nikon Coolpix8700 are compared based on equidistant model. The results of these calibrations are analyzed, using photogrammetric bundle block adjustment. This study suggests a precalibration process of these kinds of hardware for the photogrammetric process in the test field.

  6. Effects of Different Contact Lens Designs on Visual Quality Among the Soft Spherical Contact Lens Users

    Directory of Open Access Journals (Sweden)

    Mustafa Demir

    2013-10-01

    Full Text Available Purpose: To evaluate the effects of different lens designs on visual quality among soft spherical contact lens users. Material and Method: Forty eyes of twenty patients from our contact lens unit were included in this study. Refractive errors of the patients were between -0.50 and -6.0 diopters with 0.05. Total higher order aberration mean rms value was 0.29±0.10 µm without glasses, while it was 0.33±0.10 µm with Balafilcon A lenses and 0.31±0.10 µm with Senofilcon A lenses. Higher order aberration values measured after contact lens application did not show a significant difference for two contact lens designs (p>0.05. Discussion: High and low contrast sensitivity values were better with spectacles compared to contact lenses. We did not observe significant difference in higher order aberration values and visual quality between aspheric and spheric designed lenses. (Turk J Ophthalmol 2013; 43: 321-5

  7. Review of small aspheric glass lens molding technologies

    Science.gov (United States)

    Yin, Shaohui; Jia, Hongpeng; Zhang, Guanhua; Chen, Fengjun; Zhu, Kejun

    2017-01-01

    Aspheric lens can eliminate spherical aberrations, coma, astigmatism, field distortions, and other adverse factors. This type of lens can also reduce the loss of light energy and obtain high-quality images and optical characteristics. The demand for aspheric lens has increased in recent years because of its advantageous use in the electronics industry, particularly for compact, portable devices and high-performance products. As an advanced manufacturing technology, the glass lens molding process has been recognized as a low-cost and high-efficiency manufacturing technology for machining small-diameter aspheric lens for industrial production. However, the residual stress and profile deviation of the glass lens are greatly affected by various key technologies for glass lens molding, including glass and mold-die material forming, mold-die machining, and lens molding. These key technical factors, which affect the quality of the glass lens molding process, are systematically discussed and reviewed to solve the existing technical bottlenecks and problems, as well as to predict the potential applicability of glass lens molding in the future.

  8. Rho GTPase inactivation impairs lens growth and integrity.

    Science.gov (United States)

    Rao, Vasantha; Wawrousek, Eric; Tamm, Ernst R; Zigler, Samuel

    2002-02-01

    To elucidate the significance of Rho GTPase signaling on lens growth and structural integrity, we have selectively inactivated Rho GTPase in the ocular lens. To achieve this tissue-specific inactivation, a transgene encoding the C3-exoenzyme from Clostridium botulinum has been expressed in mice under transcriptional control of the lens-specific alphaA-crystallin promoter. C3-exoenzyme is known to selectively inactivate all Rho GTPase isoforms by ADP-ribosylating an asparagine residue at position 41. Mice expressing the C3-exoenzyme transgene exhibited selective ocular defects, including cataract and microphthalmia. Extralenticular effects included ocular hemorrhage (blood accumulation in the anterior and posterior chambers of the eye) and abnormalities of the iris including focal attachments to lens and cornea (synechiae). C3-transgene expression was found only in the lens and not in the other ocular tissues as determined by RT-PCR analysis. Histologic examination of the eyes of C3 transgenic mice from two independent lines revealed extensive abnormalities of the lens, including defective fiber cell differentiation and elongation, ruptured posterior lens capsule, and thickened anterior lens capsule. Electron microscopic analysis of hemorrhaged C3 eyes showed abnormalities in the posterior hyaloid vessels. Collectively these data reveal the importance of Rho GTPase signaling in regulating lens growth and maintenance of lens transparency.

  9. Radiation dose to the eye lens

    DEFF Research Database (Denmark)

    Baun, Christina; Falch Braas, Kirsten; D. Nielsen, Kamilla

    2015-01-01

    might avoid including the eye in the CT scan without losing sufficient visualization of the scull base. The aim of this study was to evaluate the possibility of decreasing the radiation dose to the eye lens, simply by changing the head position, when doing the PET/CT scan from the base of the scull......Radiation Dose to the Eye Lens: Does Positioning Really Matter? C. Baun1, K. Falch1, K.D. Nielsen2, S. Shanmuganathan1, O. Gerke1, P.F. Høilund-Carlsen1 1Department of Nuclear Medicine, Odense University Hospital, Odense C, Denmark. 2University College Lillebaelt, Odense, Denmark. Aim: The scan...... field in oncology patients undergoing eyes-to-thighs PET/CT must always include the base of the scull according to department guidelines. The eye lens is sensitive to radiation exposure and if possible it should be avoided to scan the eye. If the patient’s head is kipped backwards during the scan one...

  10. Adaptive Liquid Lens Actuated by Droplet Movement

    Directory of Open Access Journals (Sweden)

    Chao Liu

    2014-08-01

    Full Text Available In this paper we report an adaptive liquid lens actuated by droplet movement. Four rectangular PMMA (Polymethyl Methacrylate substrates are stacked to form the device structure. Two ITO (Indium Tin Oxide sheets stick on the bottom substrate. One PMMA sheet with a light hole is inserted in the middle of the device. A conductive droplet is placed on the substrate and touches the PMMA sheet to form a small closed reservoir. The reservoir is filled with another immiscible non-conductive liquid. The non-conductive liquid can form a smooth concave interface with the light hole. When the device is applied with voltage, the droplet stretches towards the reservoir. The volume of the reservoir reduces, changing the curvature of the interface. The device can thus achieve the function of an adaptive lens. Our experiments show that the focal length can be varied from −10 to −159 mm as the applied voltage changes from 0 to 65 V. The response time of the liquid lens is ~75 ms. The proposed device has potential applications in many fields such as information displays, imaging systems, and laser scanning systems.

  11. Achromobacter xylosoxidans keratitis after contact lens usage.

    Science.gov (United States)

    Park, Jung Hyun; Song, Nang Hee; Koh, Jae Woong

    2012-02-01

    To report on Achromobacter xylosoxidans keratitis in two healthy patients who had worn contact lenses foran extended period of time. A 36-year-old female and a 21-year-old female visited our hospital with ocular pain and blurred vision. Both patients had a history of wearing soft contact lenses for over fve years with occasional overnight wear. At the initial presentation, a slit lamp examination revealed corneal stromal infiltrations and epithelial defects with peripheral neovascularization in both patients. Microbiological examinations were performed from samples of corneal scrapings, contact lenses, contact lens cases, and solution. The culture resulting from the samples taken from the contact lenses, contact lens cases, and solution were all positive for Achromobacter xylosoxidans. Confrming that the direct cause of the keratitis was the contact lenses, the frst patient was prescribed ceftazidime and amikacin drops sensitive to Achromobacter xylosoxidans. The second patient was treated with 0.3% gatifoxacin and fortifed tobramycin drops. After treatment, the corneal epithelial defects were completely healed, and subepithelial corneal opacity was observed. Two cases of Achromobacter xylosoxidans keratitis were reported in healthy young females who wore soft contact lenses. Achromobacter xylosoxidans should be considered a rare but potentially harmful pathogen for lens-induced keratitis in healthy hosts.

  12. CYLINDER LENS ALIGNMENT IN THE LTP

    Energy Technology Data Exchange (ETDEWEB)

    TAKACS, P.Z.

    2005-07-26

    The Long Trace Profiler (LTP), is well-suited for the measurement of the axial figure of cylindrical mirrors that usually have a long radius of curvature in the axial direction but have a short radius of curvature in the sagittal direction. The sagittal curvature causes the probe beam to diverge in the transverse direction without coming to a focus on the detector, resulting in a very weak signal. It is useful to place a cylinder lens into the optical system above the mirror under test to refocus the sagittal divergence and increase the signal level. A positive cylinder lens can be placed at two positions above the surface: the Cat's Eye reflection position and the Wavefront-Matching position. The Cat's Eye position, is very tolerant to mirror misalignment, which is not good if absolute axial radius of curvature is to be measured. Lateral positioning and rotational misalignments of lens and the mirror combine to produce unusual profile results. This paper looks at various alignment issues with measurements and by raytrace simulations to determine the best strategy to minimize radius of curvature errors in the measurement of cylindrical aspheres.

  13. CMB lens sample covariance and consistency relations

    Science.gov (United States)

    Motloch, Pavel; Hu, Wayne; Benoit-Lévy, Aurélien

    2017-02-01

    Gravitational lensing information from the two and higher point statistics of the cosmic microwave background (CMB) temperature and polarization fields are intrinsically correlated because they are lensed by the same realization of structure between last scattering and observation. Using an analytic model for lens sample covariance, we show that there is one mode, separately measurable in the lensed CMB power spectra and lensing reconstruction, that carries most of this correlation. Once these measurements become lens sample variance dominated, this mode should provide a useful consistency check between the observables that is largely free of sampling and cosmological parameter errors. Violations of consistency could indicate systematic errors in the data and lens reconstruction or new physics at last scattering, any of which could bias cosmological inferences and delensing for gravitational waves. A second mode provides a weaker consistency check for a spatially flat universe. Our analysis isolates the additional information supplied by lensing in a model-independent manner but is also useful for understanding and forecasting CMB cosmological parameter errors in the extended Λ cold dark matter parameter space of dark energy, curvature, and massive neutrinos. We introduce and test a simple but accurate forecasting technique for this purpose that neither double counts lensing information nor neglects lensing in the observables.

  14. Retina projection using curved lens arrays

    Science.gov (United States)

    Yen, Hao-Ren; Su, Guo-Dung J.

    2016-09-01

    In this paper, we propose a multi-channel imaging system which combines the principles of an insect's compound eye and optical cluster eye. The system consists of two curved structure lens arrays with different pitches. Both of them have the same curvature and the radiuses of the lenses in the arrays are optimized to focus rays on the retina. The optical axes of different channels are tilted to each other in order to reduce the optical system volume and transmit a wide field of view. Each channel of an array of multiple optical system transfers only a part of the field of view. Each partial image passes through each channel and stitches together on the retina to reconstruct a complete image. In order to simulate the image stitching, we also build an eye model. The thickness from the panel to the last surface of lens group is less than 25mm. The panel size is designed to be 4 inch which is the scale of eyeglass. The system can provide a large field of view about 150 degrees which is much wider than the commercial products. By using the 3D printer, we can make a model of lens array to achieve our design.

  15. Pitfalls in aphakic contact lens fitting

    Directory of Open Access Journals (Sweden)

    Dada Vijay

    1990-01-01

    Full Text Available We examined 23 consecutive cases of unilateral aphakia reporting to the contact lens office for endothelial count and morphology, corneal thickness and toricity. The fellow eye served as a control in all the cases. It was found that there is a significant drop in the central endothelial cell density, and change in the size and shape of the cells. These observations indicate a thermodynamically unstable state. The aphakic corneas were thicker than the controls but not to a significant extent. The cell count and pachymetry had no statistical correlation. Toricity of the aphakic corneas make successful fitting of a lens difficult. Since prolonged use of extended wear gas permeable as well as hydrogel lenses have a deleterious effect on the endothelium it is suggested that a careful case selection be made and strict monitoting carried out at follow up. These corneas are liable for decompensation with only mild noxious stimuli. This article is intended to acquaint the ophthalmologist with the pitfalls in aphakic contact lens fitting so that a cautious follow up may be planned.

  16. Radiation dose to the eye lens

    DEFF Research Database (Denmark)

    Baun, Christina; Falch Braas, Kirsten; D. Nielsen, Kamilla

    2015-01-01

    .69 – 4.46). With the high dose protocol and position ‘kipped’, the radiation dose to the eye lens decreased by 41.5%, on average by 1.52 mSv (95% CI: 0.39-2.64; p=0.008) compared to ‘standard’, i.e., from 3.66 mSv (range 1.62 – 4.68) to 2.14 mSv (range 1.12 – 4.46). With the low dose protocol......Radiation Dose to the Eye Lens: Does Positioning Really Matter? C. Baun1, K. Falch1, K.D. Nielsen2, S. Shanmuganathan1, O. Gerke1, P.F. Høilund-Carlsen1 1Department of Nuclear Medicine, Odense University Hospital, Odense C, Denmark. 2University College Lillebaelt, Odense, Denmark. Aim: The scan...... might avoid including the eye in the CT scan without losing sufficient visualization of the scull base. The aim of this study was to evaluate the possibility of decreasing the radiation dose to the eye lens, simply by changing the head position, when doing the PET/CT scan from the base of the scull...

  17. Ultrasound field measurement using a binary lens

    CERN Document Server

    Clement, Gregory T; Kamakura, Tomoo

    2014-01-01

    Field characterization methods using a scattering target in the absence of a point-like receiver have been well described in which scattering is recorded by a relatively large receiver located outside the field of measurement. Unfortunately, such methods are prone to artifacts due to averaging across the receiver surface. To avoid this problem while simultaneously increasing the gain of a received signal, the present study introduces a binary plate lens designed to focus spherically-spreading waves onto a planar region having a nearly-uniform phase proportional to that of the target location. The lens is similar to a zone plate, but modified to produce a bi-convex-like behavior, such that it focuses both planar and spherically spreading waves. A measurement device suitable for characterizing narrowband ultrasound signals in air is designed around this lens by coupling it to a target and planar receiver. A prototype device is constructed and used to characterize the field of a highly-focused 400 kHz air transd...

  18. Micropropagação de porta-enxertos híbridos de Vitis labrusca x Vitis rotundifolia com resistência à pérola-da-terra (Eurhizococcus brasiliensis Hempel, Hemiptera: Margarodidae Micro propagation of hybrids of Vitis labrusca x Vitis rotundifolia rootstocks with resistance to perola-da-terra (Eurhizococcus brasiliensis Hempel, Hemiptera: Margarodidae

    Directory of Open Access Journals (Sweden)

    Regina Beatriz Bernd

    2007-08-01

    Full Text Available A produção homogênea de porta-enxertos resistentes à pérola-da-terra (Eurhizococcus brasiliensis Hempel, Hemiptera: Margarodidae e adaptados à região vitivinícola do Sul do País, pela técnica de micropropagação, poderá vir a atender à demanda do setor produtivo de uva e evitar as perdas causadas pela praga. O objetivo deste trabalho foi desenvolver um protocolo de micropropagação dos híbridos 1 e 2, que possuem as qualidades genéticas e de vigor desejadas para porta-enxerto, e resistência à pérola-da-terra. A partir de gemas axilares cultivadas em meio Galzy adicionado de 3µM de bezilaminopurina (BAP, foi possível induzir a multibrotação, com um número satisfatório de brotos, passível de ser incrementado por subcultivos sucessivos no mesmo meio de cultura. Os brotos obtidos neste meio e transferidos para o meio de cultura Galzy, adicionado de 8µM.10-3 de ácido naftalenoacético (ANA, enraizaram em 100%, superando a dificuldade de enraizamento que em geral tem sido a maior barreira apresentada pela espécie V. rotundifolia e seus híbridos.The homogeneous production of rootstock resistant to perola-da-terra (Eurhizococcus brasiliensis Hempel, Hemiptera: Margarodidae and well adapted to the growth conditions of the main grape growing region of Southern Brazil by the use of the micropropagation technique, may come to solve the demand of the grape productive sector and avoid losses caused by this pest. The objective of this work was to develop a protocol of micro propagation for the hybrids 1 and 2, which have the desired genetic qualities and vigor to be used as rootstock resistant to perola-da-terra. From axillaries buds cultivated in Galzy culture medium with 3µM of BAP, it was possible to induce multiple shooting with a reasonable number of shoots, which may be improved by successive subcultures in the same medium. The shoots were transferred to Galzy culture medium with 8µM.10-3 of NAA and all of them rooted

  19. Thermal Lens Spectroscopy as a 'new' analytical tool for actinide determination in nuclear reprocessing processes

    Energy Technology Data Exchange (ETDEWEB)

    Canto, Fabrice; Couston, Laurent; Magnaldo, Alastair [CEA-Valrho DEN/DRCP/SCPS/LCAM BP17171 30207 Bagnols/Ceze cedex (France); Broquin, Jean-Emmanuel [IMEP/ENSERG 23 rue des Martyrs BP257 38016 Grenoble (France); Signoret, Philippe [UM2/IES UMR 5214. Place Eugene Bataillon 34095 Montpellier cedex5 (France)

    2008-07-01

    Thermal Lens Spectroscopy (TLS) consists of measuring the effects induced by the relaxation of molecules excited by photons. Twenty years ago, the Cea already worked on TLS. Technologic reasons impeded. But, needs in sensitive analytical methods coupled with very low sample volumes (for example, traces of Np in the COEX{sup TM} process) and also the reduction of the nuclear wastes encourage us to revisit this method thanks to the improvement of optoelectronic technologies. We can also imagine coupling TLS with micro-fluidic technologies, decreasing significantly the experiments cost. Generally two laser beams are used for TLS: one for the selective excitation by molecular absorption (inducing the thermal lens) and one for probing the thermal lens. They can be coupled with different geometries, collinear or perpendicular, depending on the application and on the laser mode. Also, many possibilities of measurement have been studied to detect the thermal lens signal: interferometry, direct intensities variations, deflection etc... In this paper, one geometrical configuration and two measurements have been theoretically evaluated. For a single photodiode detection (z-scan) the limit of detection is calculated to be near 5*10{sup -6} mol*L{sup -1} for Np(IV) in dodecane. (authors)

  20. A Monte Carlo study on the effect of the orbital bone to the radiation dose delivered to the eye lens

    Science.gov (United States)

    Stratis, Andreas; Zhang, Guozhi; Jacobs, Reinhilde; Bogaerts, Ria; Bosmans, Hilde

    2015-03-01

    The aim of this work was to investigate the influence of backscatter radiation from the orbital bone and the intraorbital fat on the eye lens dose in the dental CBCT energy range. To this end we conducted three different yet interrelated studies; A preliminary simulation study was conducted to examine the impact of a bony layer situated underneath a soft tissue layer on the amount of backscatter radiation. We compared the Percentage Depth Dose (PDD) curves in soft tissue with and without the bone layer and we estimated the depth in tissue where the decrease in backscatter caused by the presence of the bone is noticeable. In a supplementary study, an eye voxel phantom was designed with the DOSxyznrc code. Simulations were performed exposing the phantom at different x-ray energies sequentially in air, in fat tissue and in realistic anatomy with the incident beam perpendicular to the phantom. Finally, a virtual head phantom was implemented into a validated hybrid Monte Carlo (MC) framework to simulate a large Field of View protocol of a real CBCT scanner and examine the influence of scattered dose to the eye lens during the whole rotation of the paired tube-detector system. The results indicated an increase in the dose to the lens due to the fatty tissue in the surrounding anatomy. There is a noticeable dose reduction close to the bone-tissue interface which weakens with increasing distance from the interface, such that the impact of the orbital bone in the eye lens dose becomes small.