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Sample records for hybrid ad-aav vector

  1. BTK gene targeting by homologous recombination using a helper-dependent adenovirus/adeno-associated virus hybrid vector.

    Science.gov (United States)

    Yamamoto, H; Ishimura, M; Ochiai, M; Takada, H; Kusuhara, K; Nakatsu, Y; Tsuzuki, T; Mitani, K; Hara, T

    2016-02-01

    X-linked agammaglobulinemia (XLA) is one of the most common humoral immunodeficiencies, which is caused by mutations in Bruton's tyrosine kinase (BTK) gene. To examine the possibility of using gene therapy for XLA, we constructed a helper-dependent adenovirus/adeno-associated virus BTK targeting vector (HD-Ad.AAV BTK vector) composed of a genomic sequence containing BTK exons 6-19 and a green fluorescence protein-hygromycin cassette driven by a cytomegalovirus promoter. We first used NALM-6, a human male pre-B acute lymphoblastic leukemia cell line, as a recipient to measure the efficiency of gene targeting by homologous recombination. We identified 10 clones with the homologous recombination of the BTK gene among 107 hygromycin-resistant stable clones isolated from two independent experiments. We next used cord blood CD34⁺ cells as the recipient cells for the gene targeting. We isolated colonies grown in medium containing cytokines and hygromycin. We found that the targeting of the BTK gene occurred in four of the 755 hygromycin-resistant colonies. Importantly, the gene targeting was also observed in CD19⁺ lymphoid progenitor cells that were differentiated from the homologous recombinant CD34⁺ cells during growth in selection media. Our study shows the potential for the BTK gene therapy using the HD-Ad.AAV BTK vector via homologous recombination in hematopoietic stem cells.

  2. Hybrid Optimization of Support Vector Machine for Intrusion Detection

    Institute of Scientific and Technical Information of China (English)

    XI Fu-li; YU Song-nian; HAO Wei

    2005-01-01

    Support vector machine (SVM) technique has recently become a research focus in intrusion detection field for its better generalization performance when given less priori knowledge than other soft-computing techniques. But the randomicity of parameter selection in its implement often prevents it achieving expected performance. By utilizing genetic algorithm (GA) to optimize the parameters in data preprocessing and the training model of SVM simultaneously, a hybrid optimization algorithm is proposed in the paper to address this problem. The experimental results demonstrate that it's an effective method and can improve the perfornance of SVM-based intrusion detection system further.

  3. Hybrid Neural Network and Support Vector Machine Method for Optimization

    Science.gov (United States)

    Rai, Man Mohan (Inventor)

    2007-01-01

    System and method for optimization of a design associated with a response function, using a hybrid neural net and support vector machine (NN/SVM) analysis to minimize or maximize an objective function, optionally subject to one or more constraints. As a first example, the NN/SVM analysis is applied iteratively to design of an aerodynamic component, such as an airfoil shape, where the objective function measures deviation from a target pressure distribution on the perimeter of the aerodynamic component. As a second example, the NN/SVM analysis is applied to data classification of a sequence of data points in a multidimensional space. The NN/SVM analysis is also applied to data regression.

  4. Hybrid Support Vector Machines-Based Multi-fault Classification

    Institute of Scientific and Technical Information of China (English)

    GAO Guo-hua; ZHANG Yong-zhong; ZHU Yu; DUAN Guang-huang

    2007-01-01

    Support Vector Machines (SVM) is a new general machine-learning tool based on structural risk minimization principle. This characteristic is very signific ant for the fault diagnostics when the number of fault samples is limited. Considering that SVM theory is originally designed for a two-class classification, a hybrid SVM scheme is proposed for multi-fault classification of rotating machinery in our paper. Two SVM strategies, 1-v-1 (one versus one) and 1-v-r (one versus rest), are respectively adopted at different classification levels. At the parallel classification level, using 1-v-1 strategy, the fault features extracted by various signal analysis methods are transferred into the multiple parallel SVM and the local classification results are obtained. At the serial classification level, these local results values are fused by one serial SVM based on 1-v-r strategy. The hybrid SVM scheme introduced in our paper not only generalizes the performance of signal binary SVMs but improves the precision and reliability of the fault classification results. The actually testing results show the availability suitability of this new method.

  5. Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution?

    Directory of Open Access Journals (Sweden)

    Anja Ehrhardt

    2009-12-01

    Full Text Available The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based on these findings major improvements in vector design including the development of viral hybrid vectors for somatic integration have been achieved. This review provides a state-of-the-art overview of available hybrid vectors utilizing viruses for high transduction efficiencies in concert with various integration machineries for random and targeted integration patterns. It discusses advantages but also limitations of each vector system.

  6. Hybrid Lentivirus-transposon Vectors With a Random Integration Profile in Human Cells

    DEFF Research Database (Denmark)

    Staunstrup, Nicklas H; Moldt, Brian; Mátés, Lajos

    2009-01-01

    Sleeping Beauty (SB) transposon vectors have a significantly safer insertion profile, but efficient delivery into relevant cell/tissue types is a limitation. In an attempt to combine the favorable features of the two vector systems we established a novel hybrid vector technology based on SB transposase...

  7. Hybrid Asymmetric Space Vector Modulation for inverter based direct torque control induction motor drive

    Directory of Open Access Journals (Sweden)

    Nandakumar Sundararaju

    2014-05-01

    Full Text Available This paper proposes novel hybrid asymmetric space vector modulation technique for inverter operated direct torque control induction motor drive. The hybridization process is performed by the combination of continuous asymmetric space vector modulation pulse width technique (ASVPWM and fuzzy operated discontinuous ASVPWM technique. Combination process is based on pulse mismatching technique. Pulse mismatching technique helps to reduce the active region of the switch. Finally, optimal pulses are applied to control the inverter. The optimal hybrid pulse condense switching losses of the inverter and also improves the operating performance of the direct torque control (DTC based drive system like smooth dynamic response in speed reversal, minimum torque error, settling time of speed. Simulation results of proposed hybrid asymmetric space vector pulse width modulation technique to direct torque control (HASVPWM-DTC approach has been carried out by using Matlab-Simulink environment.

  8. HR approximation of FIR filters via discrete-time hybrid-domain vector fitting

    OpenAIRE

    2009-01-01

    We present a discrete-time hybrid-domain vector fitting algorithm, called HD-VFz, for the HR approximation of FIR filters with an arbitrary combination of time- and frequency-sampled responses. The core routine involves a two-step pole refinement process based on a linear least-squares solve and an eigenvalue problem. Through hybrid-domain data approximation and digital partial fraction basis with relative stability consideration, HD-VFz exhibits fast computation and remarkable fitting accura...

  9. Hybrid algorithm for accelerating the double series of Floquet vector modes

    Institute of Scientific and Technical Information of China (English)

    LI Weidong; HONG Wei; HAO Zhangcheng; ZHOU Houxing

    2006-01-01

    In this paper, a hybrid algorithm for accelerating the double series of Floquet vector modes arising in the analysis of frequency selective surfaces (FSS) is presented. The asymptotic terms with slow convergence in the double series are first accelerated by Poisson transformation and Ewald method, and then the remained series is accelerated by Shank transformation. It results in significant savings in memory and computing time. Numerical examples verify the validity of the hybrid acceleration algorithm.

  10. CURRENT VECTOR CONTROL OF PERMANENT-MAGNET SYNCHRONOUS MOTOR OF HYBRID VEHICLE ENGINE

    Directory of Open Access Journals (Sweden)

    S. Serikov

    2009-01-01

    Full Text Available Characteristics of traction permanent-magnet synchronous motor under current vector optimum control in the possible traction-speed mode area which are relevant for hybrid vehicle engine have been investigated. As a criterion of optimality a maximum of electromagnetic moment per unit of current have been taken.

  11. Vectores

    OpenAIRE

    2016-01-01

    Documento que contiene la explicación sobre las temáticas de Sistemas coordenados, Cantidades vectoriales y escalares, Algunas propiedades de los vectores, Componentes de un vector y vectores unitarios

  12. Targeting the central nervous system with herpes simplex virus / Sleeping Beauty hybrid amplicon vectors.

    Science.gov (United States)

    de Silva, Suresh; Bowers, William J

    2011-10-01

    The pursuits of sustainable treatments for diseases and disorders that afflict the central nervous system (CNS) have proven challenging for the field of viral vector-based gene therapy. However, recent advances in viral vector technology coupled with efficient delivery methods have opened up new avenues that show promise at the preclinical testing stage. The development of the Herpes Simplex Virus/Sleeping Beauty (HSV/SB) hybrid vector represents such an advance for devising treatments targeting the CNS with its potential for stably integrating large transgenomic segments of DNA within the genomes of transduced cells. In utero administration of this hybrid vector into the embryonic mouse brain has revealed the capacity for widespread transgene dissemination due to the targeting of a neuronal precursor cell population. This unique feature has provided the means to stably express a transgene throughout the brain for prolonged periods, which is a prerequisite for the treatment of progressive CNS disorders. In this review we provide a comprehensive breakdown of the characteristics of the HSV/SB vector system and how it can be efficiently employed in the derivation of CNS-targeted gene therapeutic strategies.

  13. Application of Hybrid Quantum Tabu Search with Support Vector Regression (SVR for Load Forecasting

    Directory of Open Access Journals (Sweden)

    Cheng-Wen Lee

    2016-10-01

    Full Text Available Hybridizing chaotic evolutionary algorithms with support vector regression (SVR to improve forecasting accuracy is a hot topic in electricity load forecasting. Trapping at local optima and premature convergence are critical shortcomings of the tabu search (TS algorithm. This paper investigates potential improvements of the TS algorithm by applying quantum computing mechanics to enhance the search information sharing mechanism (tabu memory to improve the forecasting accuracy. This article presents an SVR-based load forecasting model that integrates quantum behaviors and the TS algorithm with the support vector regression model (namely SVRQTS to obtain a more satisfactory forecasting accuracy. Numerical examples demonstrate that the proposed model outperforms the alternatives.

  14. NOVEL HYBRID GENE VECTOR STABILIZED BY CROSS-LINKING WITH GOLD NANOPARTICLES

    Institute of Scientific and Technical Information of China (English)

    You-xiang Wang; Ying Zhu; Jia-cong Shen

    2008-01-01

    Enhanced stability of polyplexes in physiological condition was an important prerequisite for successful systemic gene delivery. Herein novel method was reported to develop stable gene vector by nanotechnology. Thiolated polyplexes were constructed and then cross-linked with gold nanoparticles (AuNPs) by gold-thiol interactions. TEM pictures showed that AuNPs were attached to the shell of spherical polyplexes. The hybrid gene vector was stable enough in physiological condition and maintained efficient transfection, which showed great potential in gene delivery research and application.

  15. A Novel Homogenous Hybridization Scheme for Performance Improvement of Support Vector Machines Regression in Reservoir Characterization

    Directory of Open Access Journals (Sweden)

    Kabiru O. Akande

    2016-01-01

    Full Text Available Hybrid computational intelligence is defined as a combination of multiple intelligent algorithms such that the resulting model has superior performance to the individual algorithms. Therefore, the importance of fusing two or more intelligent algorithms to achieve better performance cannot be overemphasized. In this work, a novel homogenous hybridization scheme is proposed for the improvement of the generalization and predictive ability of support vector machines regression (SVR. The proposed and developed hybrid SVR (HSVR works by considering the initial SVR prediction as a feature extraction process and then employs the SVR output, which is the extracted feature, as its sole descriptor. The developed hybrid model is applied to the prediction of reservoir permeability and the predicted permeability is compared to core permeability which is regarded as standard in petroleum industry. The results show that the proposed hybrid scheme (HSVR performed better than the existing SVR in both generalization and prediction ability. The outcome of this research will assist petroleum engineers to effectively predict permeability of carbonate reservoirs with higher degree of accuracy and will invariably lead to better reservoir. Furthermore, the encouraging performance of this hybrid will serve as impetus for further exploring homogenous hybrid system.

  16. A New Hybrid Algorithm for Bankruptcy Prediction Using Switching Particle Swarm Optimization and Support Vector Machines

    OpenAIRE

    2015-01-01

    Bankruptcy prediction has been extensively investigated by data mining techniques since it is a critical issue in the accounting and finance field. In this paper, a new hybrid algorithm combining switching particle swarm optimization (SPSO) and support vector machine (SVM) is proposed to solve the bankruptcy prediction problem. In particular, a recently developed SPSO algorithm is exploited to search the optimal parameter values of radial basis function (RBF) kernel of the SVM. The new algori...

  17. Transgene expression in Penaeus monodon cells: evaluation of recombinant baculoviral vectors with shrimp specific hybrid promoters.

    Science.gov (United States)

    Puthumana, Jayesh; Philip, Rosamma; Bright Singh, I S

    2016-08-01

    It has been realized that shrimp cell immortalization may not be accomplished without in vitro transformation by expressing immortalizing gene in cells. In this process, efficiency of transgene expression is confined to the ability of vectors to transmit gene of interests to the genome. Over the years, unavailability of such vectors has been hampering application of such a strategy in shrimp cells. We report the use of recombinant baculovirus mediated transduction using hybrid promoter system for transgene expression in lymphoid cells of Penaeus monodon. Two recombinant baculovirus vectors with shrimp viral promoters (WSSV-Ie1 and IHHNV-P2) were constructed (BacIe1-GFP and BacP2-GFP) and green fluorescent protein (GFP) used as the transgene. The GFP expression in cells under the control of hybrid promoters, PH-Ie1 or PH-P2, were analyzed and confirmed in shrimp cells. The results indicate that the recombinant baculovirus with shrimp specific viral promoters (hybrid) can be employed for delivery of foreign genes to shrimp cells for in vitro transformation.

  18. Underwater hybrid near-field acoustical holography based on the measurement of vector hydrophone array

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Hybrid near-field acoustical holography(NAH) is developed for reconstructing acoustic radiation from a cylindrical source in a complex underwater environment. In hybrid NAH,we combine statistically optimized near-field acoustical holography(SONAH) and broadband acoustical holography from intensity measurements(BAHIM) to reconstruct the underwater cylindrical source field. First,the BAHIM is utilized to regenerate as much acoustic pressures on the hologram surface as necessary,and then the acoustic pressures are taken as input to the formulation implemented numerically by SONAH. The main advantages of this technology are that the complex pressure on the hologram surface can be reconstructed without reference signal,and the measurement array can be smaller than the source,thus the practicability and efficiency of this technology are greatly enhanced. Numerical examples of a cylindrical source are demonstrated. Test results show that hybrid NAH can yield a more accurate reconstruction than conventional NAH. Then,an experiment has been carried out with a vector hydrophone array. The experimental results show the advantage of hybrid NAH in the reconstruction of an acoustic field and the feasibility of using a vector hydrophone array in an underwater NAH measurement,as well as the identification and localization of noise sources.

  19. Vectors

    DEFF Research Database (Denmark)

    Boeriis, Morten; van Leeuwen, Theo

    2017-01-01

    This article revisits the concept of vectors, which, in Kress and van Leeuwen’s Reading Images (2006), plays a crucial role in distinguishing between ‘narrative’, action-oriented processes and ‘conceptual’, state-oriented processes. The use of this concept in image analysis has usually focused...... on the most salient vectors, and this works well, but many images contain a plethora of vectors, which makes their structure quite different from the linguistic transitivity structures with which Kress and van Leeuwen have compared ‘narrative’ images. It can also be asked whether facial expression vectors...... should be taken into account in discussing ‘reactions’, which Kress and van Leeuwen link only to eyeline vectors. Finally, the question can be raised as to whether actions are always realized by vectors. Drawing on a re-reading of Rudolf Arnheim’s account of vectors, these issues are outlined...

  20. Exchange coupling in hybrid anisotropy magnetic multilayers quantified by vector magnetometry

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, C., E-mail: C.Morrison.2@warwick.ac.uk; Miles, J. J.; Thomson, T. [School of Computer Science, University of Manchester, Manchester M13 9PL (United Kingdom); Anh Nguyen, T. N. [Materials Physics, School of ICT, KTH Royal Institute of Technology, Electrum 229, 164 40 Kista (Sweden); Spintronics Research Group, Laboratory for Nanotechnology (LNT), VNU-HCM, Ho Chi Minh City (Viet Nam); Fang, Y.; Dumas, R. K. [Department of Physics, University of Gothenburg, 412 96 Gothenburg (Sweden); Åkerman, J. [Materials Physics, School of ICT, KTH Royal Institute of Technology, Electrum 229, 164 40 Kista (Sweden); Department of Physics, University of Gothenburg, 412 96 Gothenburg (Sweden)

    2015-05-07

    Hybrid anisotropy thin film heterostructures, where layers with perpendicular and in-plane anisotropy are separated by a thin spacer, are novel materials for zero/low field spin torque oscillators and bit patterned media. Here, we report on magnetization reversal and exchange coupling in a archetypal Co/Pd (perpendicular)-NiFe (in-plane) hybrid anisotropy system studied using vector vibrating sample magnetometry. This technique allows us to quantify the magnetization reversal in each individual magnetic layer, and measure of the interlayer exchange as a function of non-magnetic spacer thickness. At large (>1 nm) spacer thicknesses Ruderman-Kittel-Kasuya-Yosida-like exchange dominates, with orange-peel coupling providing a significant contribution only for sub-nm spacer thickness.

  1. A hybrid least squares support vector machines and GMDH approach for river flow forecasting

    Science.gov (United States)

    Samsudin, R.; Saad, P.; Shabri, A.

    2010-06-01

    This paper proposes a novel hybrid forecasting model, which combines the group method of data handling (GMDH) and the least squares support vector machine (LSSVM), known as GLSSVM. The GMDH is used to determine the useful input variables for LSSVM model and the LSSVM model which works as time series forecasting. In this study the application of GLSSVM for monthly river flow forecasting of Selangor and Bernam River are investigated. The results of the proposed GLSSVM approach are compared with the conventional artificial neural network (ANN) models, Autoregressive Integrated Moving Average (ARIMA) model, GMDH and LSSVM models using the long term observations of monthly river flow discharge. The standard statistical, the root mean square error (RMSE) and coefficient of correlation (R) are employed to evaluate the performance of various models developed. Experiment result indicates that the hybrid model was powerful tools to model discharge time series and can be applied successfully in complex hydrological modeling.

  2. Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive sleeping beauty transposase for somatic integration.

    Directory of Open Access Journals (Sweden)

    Wenli Zhang

    Full Text Available We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyperactive Sleeping Beauty (SB transposase HSB5 for somatic integration and we could show stabilized transgene expression in mice and a canine model for hemophilia B. However, the safety profile of these hybrid-vectors with respect to vector dose and genotoxicity remains to be investigated. Herein, we evaluated this hybrid-vector system in C57Bl/6 mice with escalating vector dose settings. We found that in all mice which received the hyperactive SB transposase, transgene expression levels were stabilized in a dose-dependent manner and that the highest vector dose was accompanied by fatalities in mice. To analyze potential genotoxic side-effects due to somatic integration into host chromosomes, we performed a genome-wide integration site analysis using linker-mediated PCR (LM-PCR and linear amplification-mediated PCR (LAM-PCR. Analysis of genomic DNA samples obtained from HSB5 treated female and male mice revealed a total of 1327 unique transposition events. Overall the chromosomal distribution pattern was close-to-random and we observed a random integration profile with respect to integration into gene and non-gene areas. Notably, when using the LM-PCR protocol, 27 extra-chromosomal integration events were identified, most likely caused by transposon excision and subsequent transposition into the delivered adenoviral vector genome. In total, this study provides a careful evaluation of the safety profile of adenovirus/Sleeping Beauty transposase hybrid-vectors. The obtained information will be useful when designing future preclinical studies utilizing hybrid-vectors in small and large animal models.

  3. A hybrid quantum encoding algorithm of vector quantization for image compression

    Institute of Scientific and Technical Information of China (English)

    Pang Chao-Yang; Zhou Zheng-Wei; Guo Guang-Can

    2006-01-01

    Many classical encoding algorithms of vector quantization (VQ) of image compression that can obtain global optimal solution have computational complexity O(N). A pure quantum VQ encoding algorithm with probability of success near 100% has been proposed, that performs operations 45√N times approximately. In this paper, a hybrid quantum VQ encoding algorithm between the classical method and the quantum algorithm is presented. The number of its operations is less than √N for most images, and it is more efficient than the pure quantum algorithm.

  4. A hybrid state vector approach to aeroelastic analysis with application to composite lifting surfaces

    Science.gov (United States)

    Lehman, L. L.

    1981-01-01

    A computational technique has been developed for performing preliminary design aeroelastic analyses of large aspect ratio lifting surfaces. This technique, applicable to both fixed and rotating wing configurations, is based upon a formulation of the structural equilibrium equations in terms of a hybrid state vector containing generalized force and displacement variables. An integrating matrix is employed to solve these equations for divergence and flutter eigenvalues and steady aeroelastic deformation. Results are presented for simple examples which verify the technique and demonstrate how it can be applied to analyze lifting surfaces, including those constructed from composite materials.

  5. Discrimination of Maize Haploid Seeds from Hybrid Seeds Using Vis Spectroscopy and Support Vector Machine Method.

    Science.gov (United States)

    Liu, Jin; Guo, Ting-ting; Li, Hao-chuan; Jia, Shi-qiang; Yan, Yan-lu; An, Dong; Zhang, Yao; Chen, Shao-jiang

    2015-11-01

    Doubled haploid (DH) lines are routinely applied in the hybrid maize breeding programs of many institutes and companies for their advantages of complete homozygosity and short breeding cycle length. A key issue in this approach is an efficient screening system to identify haploid kernels from the hybrid kernels crossed with the inducer. At present, haploid kernel selection is carried out manually using the"red-crown" kernel trait (the haploid kernel has a non-pigmented embryo and pigmented endosperm) controlled by the R1-nj gene. Manual selection is time-consuming and unreliable. Furthermore, the color of the kernel embryo is concealed by the pericarp. Here, we establish a novel approach for identifying maize haploid kernels based on visible (Vis) spectroscopy and support vector machine (SVM) pattern recognition technology. The diffuse transmittance spectra of individual kernels (141 haploid kernels and 141 hybrid kernels from 9 genotypes) were collected using a portable UV-Vis spectrometer and integrating sphere. The raw spectral data were preprocessed using smoothing and vector normalization methods. The desired feature wavelengths were selected based on the results of the Kolmogorov-Smirnov test. The wavelengths with p values above 0. 05 were eliminated because the distributions of absorbance data in these wavelengths show no significant difference between haploid and hybrid kernels. Principal component analysis was then performed to reduce the number of variables. The SVM model was evaluated by 9-fold cross-validation. In each round, samples of one genotype were used as the testing set, while those of other genotypes were used as the training set. The mean rate of correct discrimination was 92.06%. This result demonstrates the feasibility of using Vis spectroscopy to identify haploid maize kernels. The method would help develop a rapid and accurate automated screening-system for haploid kernels.

  6. The Hybrid Dynamic Prototype Construction and Parameter Optimization with Genetic Algorithm for Support Vector Machine

    Directory of Open Access Journals (Sweden)

    Chun-Liang Lu

    2015-10-01

    Full Text Available The optimized hybrid artificial intelligence model is a potential tool to deal with construction engineering and management problems. Support vector machine (SVM has achieved excellent performance in a wide variety of applications. Nevertheless, how to effectively reduce the training complexity for SVM is still a serious challenge. In this paper, a novel order-independent approach for instance selection, called the dynamic condensed nearest neighbor (DCNN rule, is proposed to adaptively construct prototypes in the training dataset and to reduce the redundant or noisy instances in a classification process for the SVM. Furthermore, a hybrid model based on the genetic algorithm (GA is proposed to simultaneously optimize the prototype construction and the SVM kernel parameters setting to enhance the classification accuracy. Several UCI benchmark datasets are considered to compare the proposed hybrid GA-DCNN-SVM approach with the previously published GA-based method. The experimental results illustrate that the proposed hybrid model outperforms the existing method and effectively improves the classification performance for the SVM.

  7. Quantitative evaluation of orbital hybridization in carbon nanotubes under radial deformation using π-orbital axis vector

    Directory of Open Access Journals (Sweden)

    Masato Ohnishi

    2015-04-01

    Full Text Available When a radial strain is applied to a carbon nanotube (CNT, the increase in local curvature induces orbital hybridization. The effect of the curvature-induced orbital hybridization on the electronic properties of CNTs, however, has not been evaluated quantitatively. In this study, the strength of orbital hybridization in CNTs under homogeneous radial strain was evaluated quantitatively. Our analyses revealed the detailed procedure of the change in electronic structure of CNTs. In addition, the dihedral angle, the angle between π-orbital axis vectors of adjacent atoms, was found to effectively predict the strength of local orbital hybridization in deformed CNTs.

  8. A top-down approach for construction of hybrid polymer-virus gene delivery vectors.

    Science.gov (United States)

    Ramsey, Joshua D; Vu, Halong N; Pack, Daniel W

    2010-05-21

    Safe and efficient delivery of therapeutic nucleic acids remains the primary hurdle for human gene therapy. While many researchers have attempted to re-engineer viruses to be suited for gene delivery, others have sought to develop non-viral alternatives. We have developed a complementary approach in which viral and synthetic components are combined to form hybrid nanoparticulate vectors. In particular, we complexed non-infectious retrovirus-like particles lacking a viral envelope protein, from Moloney murine leukemia virus (M-VLP) or human immunodeficiency virus (H-VLP), with poly-L-lysine (PLL) or polyethylenimine (PEI) over a range of polymer/VLP ratios. At appropriate stoichiometry (75-250 microg polymer/10(6) VLP), the polymers replace the function of the viral envelope protein and interact with the target cell membrane, initiate cellular uptake and facilitate escape from endocytic vesicles. The viral particle, once in the cytosol, efficiently completes its normal infection process including integration of viral genes with the host genome as demonstrated by long-term (at least 5 weeks) transgene expression. In addition, hybrid vectors comprising H-VLP were shown to be capable of infecting non-dividing cells.

  9. Retroviral hybrid LTR vector strategy: functional analysis of LTR elements and generation of endothelial cell specificity.

    Science.gov (United States)

    Richardson, T B; Kaspers, J; Porter, C D

    2004-05-01

    Transcriptional targeting is an important aspect of developing gene therapy vectors in order to restrict transgene expression to selected target cells. One approach, when using retroviral vectors, is to replace viral transcriptional control elements within the long terminal repeat (LTR) with sequences imparting the desired specificity. We have developed such hybrid LTR retroviruses, incorporating sequences from each of the human promoters for flt-1, ICAM-2 and KDR, as part of our antivascular cancer gene therapy strategy targeting tumour endothelial cells. The chosen fragments were used to replace the enhancer or combined enhancer and proximal promoter regions of the viral LTR. All showed activity in primary human breast microvascular endothelial cells, with viruses incorporating ICAM-2 sequences exhibiting the greatest specificity versus nonendothelial cells in vitro and a marked alteration of specificity towards endothelial cells in a subcutaneous xenograft model in vivo. Moreover, our study documents the effect of enhancer and/or proximal promoter deletion on LTR activity and reports that differential dependence in different cell lines can give the false impression of specificity if experiments are not adequately controlled. This finding also has implications for other retroviral vector designs seeking to provide transcriptional specificity and for their safety with respect to prevention of gene activation at sites of proviral integration.

  10. A High-Capacity Adenoviral Hybrid Vector System Utilizing the Hyperactive Sleeping Beauty Transposase SB100X for Enhanced Integration.

    Science.gov (United States)

    Boehme, Philip; Zhang, Wenli; Solanki, Manish; Ehrke-Schulz, Eric; Ehrhardt, Anja

    2016-07-19

    For efficient delivery of required genetic elements we utilized high-capacity adenoviral vectors in the past allowing high transgene capacities of up to 36 kb. Previously we explored the hyperactive Sleeping Beauty (SB) transposase (HSB5) for somatic integration from the high-capacity adenoviral vectors genome. To further improve this hybrid vector system we hypothesized that the previously described hyperactive SB transposase SB100X will result in significantly improved efficacies after transduction of target cells. Plasmid based delivery of the SB100X system revealed significantly increased integration efficiencies compared with the previously published hyperactive SB transposase HSB5. After optimizing experimental setups for high-capacity adenoviral vectors-based delivery of the SB100X system we observed up to eightfold and 100-fold increased integration efficiencies compared with the previously published hyperactive SB transposase HSB5 and the inactive transposase mSB, respectively. Furthermore, transposon copy numbers per cell were doubled with SB100X compared with HSB5 when using the identical multiplicity of infection. We believe that this improved hybrid vector system represents a valuable tool for achieving stabilized transgene expression in cycling cells and for treatment of numerous genetic disorders. Especially for in vivo approaches this improved adenoviral hybrid vector system will be advantageous because it may potentially allow reduction of the applied viral dose.

  11. Hybrid independent component analysis and twin support vector machine learning scheme for subtle gesture recognition.

    Science.gov (United States)

    Naik, Ganesh R; Kumar, Dinesh K; Jayadeva

    2010-10-01

    Myoelectric signal classification is one of the most difficult pattern recognition problems because large variations in surface electromyogram features usually exist. In the literature, attempts have been made to apply various pattern recognition methods to classify surface electromyography into components corresponding to the activities of different muscles, but this has not been very successful, as some muscles are bigger and more active than others. This results in dataset discrepancy during classification. Multicategory classification problems are usually solved by solving many, one-versus-rest binary classification tasks. These subtasks unsurprisingly involve unbalanced datasets. Consequently, we need a learning methodology that can take into account unbalanced datasets in addition to large variations in the distributions of patterns corresponding to different classes. Here, we attempt to address the above issues using hybrid features extracted from independent component analysis and twin support vector machine techniques.

  12. Hybrid state vector methods for structural dynamic and aeroelastic boundary value problems

    Science.gov (United States)

    Lehman, L. L.

    1982-01-01

    A computational technique is developed that is suitable for performing preliminary design aeroelastic and structural dynamic analyses of large aspect ratio lifting surfaces. The method proves to be quite general and can be adapted to solving various two point boundary value problems. The solution method, which is applicable to both fixed and rotating wing configurations, is based upon a formulation of the structural equilibrium equations in terms of a hybrid state vector containing generalized force and displacement variables. A mixed variational formulation is presented that conveniently yields a useful form for these state vector differential equations. Solutions to these equations are obtained by employing an integrating matrix method. The application of an integrating matrix provides a discretization of the differential equations that only requires solutions of standard linear matrix systems. It is demonstrated that matrix partitioning can be used to reduce the order of the required solutions. Results are presented for several example problems in structural dynamics and aeroelasticity to verify the technique and to demonstrate its use. These problems examine various types of loading and boundary conditions and include aeroelastic analyses of lifting surfaces constructed from anisotropic composite materials.

  13. Production of Hybrid Chimeric PVX Particles Using a Combination of TMV and PVX-Based Expression Vectors.

    Science.gov (United States)

    Dickmeis, Christina; Honickel, Mareike Michaela Antonia; Fischer, Rainer; Commandeur, Ulrich

    2015-01-01

    We have generated hybrid chimeric potato virus X (PVX) particles by coexpression of different PVX coat protein fusions utilizing tobacco mosaic virus (TMV) and PVX-based expression vectors. Coinfection was achieved with a modified PVX overcoat vector displaying a fluorescent protein and a TMV vector expressing another PVX fluorescent overcoat fusion protein. Coexpression of the PVX-CP fusions in the same cells was confirmed by epifluorescence microscopy. Labeling with specific antibodies and transmission electron microscopy revealed chimeric particles displaying green fluorescent protein and mCherry on the surface. These data were corroborated by bimolecular fluorescence complementation. We used split-mCherry fragments as PVX coat fusions and confirmed an interaction between the split-mCherry fragments in coinfected cells. The presence of assembled split-mCherry on the surface confirmed the hybrid character of the chimeric particles.

  14. Forecasting monthly groundwater level fluctuations in coastal aquifers using hybrid Wavelet packet–Support vector regression

    Directory of Open Access Journals (Sweden)

    N. Sujay Raghavendra

    2015-12-01

    Full Text Available This research demonstrates the state-of-the-art capability of Wavelet packet analysis in improving the forecasting efficiency of Support vector regression (SVR through the development of a novel hybrid Wavelet packet–Support vector regression (WP–SVR model for forecasting monthly groundwater level fluctuations observed in three shallow unconfined coastal aquifers. The Sequential Minimal Optimization Algorithm-based SVR model is also employed for comparative study with WP–SVR model. The input variables used for modeling were monthly time series of total rainfall, average temperature, mean tide level, and past groundwater level observations recorded during the period 1996–2006 at three observation wells located near Mangalore, India. The Radial Basis function is employed as a kernel function during SVR modeling. Model parameters are calibrated using the first seven years of data, and the remaining three years data are used for model validation using various input combinations. The performance of both the SVR and WP–SVR models is assessed using different statistical indices. From the comparative result analysis of the developed models, it can be seen that WP–SVR model outperforms the classic SVR model in predicting groundwater levels at all the three well locations (e.g. NRMSE(WP–SVR = 7.14, NRMSE(SVR = 12.27; NSE(WP–SVR = 0.91, NSE(SVR = 0.8 during the test phase with respect to well location at Surathkal. Therefore, using the WP–SVR model is highly acceptable for modeling and forecasting of groundwater level fluctuations.

  15. Hybrid wavelet-support vector machine approach for modelling rainfall-runoff process.

    Science.gov (United States)

    Komasi, Mehdi; Sharghi, Soroush

    2016-01-01

    Because of the importance of water resources management, the need for accurate modeling of the rainfall-runoff process has rapidly grown in the past decades. Recently, the support vector machine (SVM) approach has been used by hydrologists for rainfall-runoff modeling and the other fields of hydrology. Similar to the other artificial intelligence models, such as artificial neural network (ANN) and adaptive neural fuzzy inference system, the SVM model is based on the autoregressive properties. In this paper, the wavelet analysis was linked to the SVM model concept for modeling the rainfall-runoff process of Aghchai and Eel River watersheds. In this way, the main time series of two variables, rainfall and runoff, were decomposed to multiple frequent time series by wavelet theory; then, these time series were imposed as input data on the SVM model in order to predict the runoff discharge one day ahead. The obtained results show that the wavelet SVM model can predict both short- and long-term runoff discharges by considering the seasonality effects. Also, the proposed hybrid model is relatively more appropriate than classical autoregressive ones such as ANN and SVM because it uses the multi-scale time series of rainfall and runoff data in the modeling process.

  16. HYBRID CORDIC TRIGONOMETRIC VECTOR ROTATION MODE for AUTHENTICATING EAR and FINGER IMAGES

    Directory of Open Access Journals (Sweden)

    R. Parimala

    2015-10-01

    Full Text Available Security is a major issue as far as the use of computers is concerned. As computer technology is becoming more complex the problem of security is also becoming complex. The ingenuity of the human brain is such that for every innovation which has positive use there is also a parallel innovation in circumventing the positiveness of that use and it comes up with an antidote to that positivity. The problem of hackers and with the evolution of the idea of cloud computing security has become an important issue. In this paper we are primarily concerned with the problem of access control and authentication. As everyone knows biometrics is used for authentication in computer science. Biometrics identifies physical characteristics of the human beings that are distinctive to each individual and are easily measured. Among other things the popular physiological feature that has stood the test of time is finger print matching which is mostly used in forensic science. In recent years ear matching is also considered a possible physiological feature for authentication and identification of individuals. Now the question is how fool proof are these? In this paper we attempt to review recent literatures on these and applying Hybrid CORDIC Trigonometric Vector Rotation Mode algorithm and taking a pair of index fingers and a pair of ears as test cases we found better results in accuracy.

  17. A Hybrid Vector Quantization Combining a Tree Structure and a Voronoi Diagram

    Directory of Open Access Journals (Sweden)

    Yeou-Jiunn Chen

    2014-01-01

    Full Text Available Multimedia data is a popular communication medium, but requires substantial storage space and network bandwidth. Vector quantization (VQ is suitable for multimedia data applications because of its simple architecture, fast decoding ability, and high compression rate. Full-search VQ can typically be used to determine optimal codewords, but requires considerable computational time and resources. In this study, a hybrid VQ combining a tree structure and a Voronoi diagram is proposed to improve VQ efficiency. To efficiently reduce the search space, a tree structure integrated with principal component analysis is proposed, to rapidly determine an initial codeword in low-dimensional space. To increase accuracy, a Voronoi diagram is applied to precisely enlarge the search space by modeling relations between each codeword. This enables an optimal codeword to be efficiently identified by rippling an optimal neighbor from parts of neighboring Voronoi regions. The experimental results demonstrated that the proposed approach improved VQ performance, outperforming other approaches. The proposed approach also satisfies the requirements of handheld device application, namely, the use of limited memory and network bandwidth, when a suitable number of dimensions in principal component analysis is selected.

  18. Fortification of Hybrid Intrusion Detection System Using Variants of Neural Networks and Support Vector Machines

    Directory of Open Access Journals (Sweden)

    A. M. Chandrashekhar

    2013-02-01

    Full Text Available Intrusion Detection Systems (IDS form a key part of system defence, where it identifies abnormalactivities happening in a computer system. In recent years different soft computing based techniques havebeen proposed for the development of IDS. On the other hand, intrusion detection is not yet a perfecttechnology. This has provided an opportunity for data mining to make quite a lot of importantcontributions in the field of intrusion detection. In this paper we have proposed a new hybrid techniqueby utilizing data mining techniques such as fuzzy C means clustering, Fuzzy neural network / Neurofuzzyand radial basis function(RBF SVM for fortification of the intrusion detection system. Theproposed technique has five major steps in which, first step is to perform the relevance analysis, and theninput data is clustered using Fuzzy C-means clustering. After that, neuro-fuzzy is trained, such that eachof the data point is trained with the corresponding neuro-fuzzy classifier associated with the cluster.Subsequently, a vector for SVM classification is formed and in the last step, classification using RBFSVMis performed to detect intrusion has happened or not. Data set used is the KDD cup 1999 datasetand we have used precision, recall, F-measure and accuracy as the evaluation metrics parameters. Ourtechnique could achieve better accuracy for all types of intrusions. The results of proposed technique arecompared with the other existing techniques. These comparisons proved the effectiveness of ourtechnique.

  19. Hybrid calibration method for six-component force/torque transducers of wind tunnel balance based on support vector machines

    Institute of Scientific and Technical Information of China (English)

    Ma Yingkun; Xie Shilin; Zhang Xinong; Luo Yajun

    2013-01-01

    A hybrid calibration approach based on support vector machines (SVM) is proposed to characterize nonlinear cross coupling of multi-dimensional transducer.It is difficult to identify these unknown nonlinearities and crosstalk just with a single conventional calibration approach.In this paper,a hybrid model comprising calibration matrix and SVM model for calibrating linearity and nonlinearity respectively is built up.The calibration matrix is determined by linear artificial neural network (ANN),and the SVM is used to compensate for the nonlinear cross coupling among each dimension.A simulation of the calibration of a multi-dimensional sensor is conducted by the SVM hybrid calibration method,which is then utilized to calibrate a six-component force/torque transducer of wind tunnel balance.From the calibrating results,it can be indicated that the SVM hybrid calibration method has improved the calibration accuracy significantly without increasing data samples,compared with calibration matrix.Moreover,with the calibration matrix,the hybrid model can provide a basis for the design of transducers.

  20. Self-assembled cationic micelles based on PEG-PLL-PLLeu hybrid polypeptides as highly effective gene vectors.

    Science.gov (United States)

    Deng, Jizhe; Gao, Ningning; Wang, Yanan; Yi, Huqiang; Fang, Shengtao; Ma, Yifan; Cai, Lintao

    2012-11-12

    Developing safe and effective nonviral gene vector is highly crucial for successful gene therapy. In the present study, we designed a series of biodegradable micelles based on hybrid polypeptide copolymers of poly(ethylene glycol)-b-poly(l-lysine)-b-poly(l-leucine) (PEG-PLL-PLLeu) for efficient gene delivery. A group of amphiphilic PEG-PLL-PLLeu hybrid polypeptide copolymers were synthesized by ring-opening polymerization of N-carboxyanhydride, and the chemical structure of each copolymer was characterized by (1)H NMR and FT-IR spectroscopy measurement. The PEG-PLL-PLLeu micelles were positively charged with tunable sizes ranging from 40 to 90 nm depending on the length of PLL and PLLeu segment. Compared with PEG-PLL copolymers, PEG-PLL-PLLeu micelles demonstrated significantly higher transfection efficiency and less cytotoxicity. Furthermore, the transfection efficiency and biocompatibility of the micelles can be simultaneously improved by tuning the length of PLL and PLLeu segments. The transfection efficiency of PEG-PLL-PLLeu micelles in vivo was two to three times higher than that of PEI(25k), which was attributable to their capability of promoting DNA condensation and cell internalization as well as successful lysosome escape. Hence well-defined PEG-PLL-PLLeu micelles would serve as highly effective nonviral vectors for in vivo gene delivery.

  1. Predicting quantitative structure-activity relationship of substituted 17α-acetoxyprogesterones by molecular hybridization electronegativity-distance vector

    Institute of Scientific and Technical Information of China (English)

    SUN Li-li; LAN Yu-kun; ZHOU Li-ping; YU Yu; LI Zhi-liang

    2007-01-01

    A set of novel structural descriptors (molecular hybridization electronegativity-distance vector, VMEDh) was put forward, and the quantitative structure-activity relationship (QSAR) of a series of 17α-Acetoxyprogesterones (Aps) was investigated. Taking into account the effect of various hybridized orbits on atomic electronegativities, we developed the structure descriptors with amended electronegativities to build a QSAR model. The 10-parameter model based on VMEDh yields a correlation coefficient R=0.972 and standard deviation SD=0.262, which are more desirable than those of the previous molecular electonegativity-distance vector (MEDV-4) (R=0.969, SD=0.275). By stepwise multiple linear regression, several parameters are selected to construct optimal models. The 7-parameter model based on VMEDh has R=0.960 and SD=0.276; its correlation coefficient (RCV) and standard deviation (SDCV) for leave-one-out procedure crossvalidation are respectively RCV=0.890 and SDCV=0.445. The 6-parameter MEDV-4 model has R=0.946, SD=0.304, RCV=0.903 and SDCV=0.406. It is demonstrated that VMEDh has desirable estimation performance and good predictive capability for this series of chemical compounds.

  2. Development of a novel adenovirus-alphavirus hybrid vector with RNA replicon features for malignant hematopoietic cell transduction.

    Science.gov (United States)

    Yang, Y; Xiao, F; Lu, Z; Li, Z; Zuo, H; Zhang, Q; Li, Q; Wang, H; Wang, L-S

    2013-08-01

    To improve the expression levels of transgenes in malignant hematopoietic cells, we developed a novel adenoviral-alphavirus hybrid vector Ad5/F11p-SFV-GFP that contains a Semliki Forest Virus (SFV) replicon and chimeric fibers of Ad5 and Ad11p. Ad5/F11p-SFV-GFP infected >95% of K562, U937 or Jurkat cells and 23.65% of HL-60 cells, and led to moderate Enhanced Green Fluorescent Protein (EGFP) transgene expression intensity. The infection efficiency of Ad5/F11p-SFV-GFP in primary human leukemia cells ranged from 9.34-89.63% (median, 28.58%) at a multiplicity of infection (MOI) of 100, compared with only 3.37-44.54% (median, 10.42%) in cells infected by Ad5/F11p-GFP. Importantly, Ad5/F11p-SFV-GFP led to a significantly higher transgene expression level in primary leukemia cells, as indicated by the relative fluorescence intensity, compared to cells infected with Ad5/F11p-GFP. The increased expression of EGFP in Ad5/F11p-SFV-GFP-infected cells was associated with the accumulation of abundant subgenomic mRNA. Additionally, infection of K562, U937 or Jurkat cells by Ad5/F11p-SFV-GFP was significantly inhibited by blocking CD46 receptor; however, other factors may affect the gene-transfer efficiency of Ad5/F11p-SFV-GFP in primary leukemia cells. In conclusion, we successfully developed a novel adenoviral-alphavirus hybrid vector with RNA replicon features, which represents a promising vector for gene modifications during the production of cell-based vaccines for leukemia patients.

  3. RDNA cloning vector pVE1, deletion and hybrid mutants and recombinant derivatives thereof products and processes

    Energy Technology Data Exchange (ETDEWEB)

    MacNeil, T.; Gibbons, P.H.

    1987-10-27

    This patent describes novel plasmid pVE1, deletion mutants thereof, recombinant derivatives thereof, which is the same as the genome or nucleic acid of such plasmids and derivatives of such genome, which are useful as recombinant DNA cloning vectors into host organisms, such as bacteria, for example, Streptomyces avermitilis. Portions of such plasmid genome are additionally useful as adjuncts in recombinant DNA cloning procedures, for examples: 1. to permit the maintenance of cloned DNA in the host, either in an integrated state or as an autonomous element; 2. to serve as promoters for increasing expression of endogenous or foreign genes wherein the promoters are ligated to such genes or otherwise serve as promoters; and 3. to serve as regulatory elements for achieving control over endogenous and foreign gene expression. As cloning vectors, pVE1 its deletion mutants, and other derivatives serve for the amplification and transfer of DNA sequences (genes) coding for useful functions. Such modified cloning vectors are introduced into the recipient organism by conjugation or transformation; wherein the hybrid DNA functions in an integrated mode and/or in plasmid mode.

  4. The Weighted Support Vector Machine Based on Hybrid Swarm Intelligence Optimization for Icing Prediction of Transmission Line

    Directory of Open Access Journals (Sweden)

    Xiaomin Xu

    2015-01-01

    Full Text Available Not only can the icing coat on transmission line cause the electrical fault of gap discharge and icing flashover but also it will lead to the mechanical failure of tower, conductor, insulators, and others. It will bring great harm to the people’s daily life and work. Thus, accurate prediction of ice thickness has important significance for power department to control the ice disaster effectively. Based on the analysis of standard support vector machine, this paper presents a weighted support vector machine regression model based on the similarity (WSVR. According to the different importance of samples, this paper introduces the weighted support vector machine and optimizes its parameters by hybrid swarm intelligence optimization algorithm with the particle swarm and ant colony (PSO-ACO, which improves the generalization ability of the model. In the case study, the actual data of ice thickness and climate in a certain area of Hunan province have been used to predict the icing thickness of the area, which verifies the validity and applicability of this proposed method. The predicted results show that the intelligent model proposed in this paper has higher precision and stronger generalization ability.

  5. A Short-Term and High-Resolution System Load Forecasting Approach Using Support Vector Regression with Hybrid Parameters Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Huaiguang [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-08-25

    This work proposes an approach for distribution system load forecasting, which aims to provide highly accurate short-term load forecasting with high resolution utilizing a support vector regression (SVR) based forecaster and a two-step hybrid parameters optimization method. Specifically, because the load profiles in distribution systems contain abrupt deviations, a data normalization is designed as the pretreatment for the collected historical load data. Then an SVR model is trained by the load data to forecast the future load. For better performance of SVR, a two-step hybrid optimization algorithm is proposed to determine the best parameters. In the first step of the hybrid optimization algorithm, a designed grid traverse algorithm (GTA) is used to narrow the parameters searching area from a global to local space. In the second step, based on the result of the GTA, particle swarm optimization (PSO) is used to determine the best parameters in the local parameter space. After the best parameters are determined, the SVR model is used to forecast the short-term load deviation in the distribution system.

  6. Characterization of interdigitated electrode structures for water contaminant detection using a hybrid voltage divider and a vector network analyzer.

    Science.gov (United States)

    Rodríguez-Delgado, José Manuel; Rodríguez-Delgado, Melissa Marlene; Mendoza-Buenrostro, Christian; Dieck-Assad, Graciano; Omar Martínez-Chapa, Sergio

    2012-01-01

    Interdigitated capacitive electrode structures have been used to monitor or actuate over organic and electrochemical media in efforts to characterize biochemical properties. This article describes a method to perform a pre-characterization of interdigitated electrode structures using two methods: a hybrid voltage divider (HVD) and a vector network analyzer (VNA). Both methodologies develop some tests under two different conditions: free air and bi-distilled water media. Also, the HVD methodology is used for other two conditions: phosphate buffer with laccase (polyphenoloxidase; EC 1.10.3.2) and contaminated media composed by a mix of phosphate buffer and 3-ethylbenzothiazoline-6-sulfonic acid (ABTS). The purpose of this study is to develop and validate a characterization methodology using both, a hybrid voltage divider and VNA T-# network impedance models of the interdigitated capacitive electrode structure that will provide a shunt RC network of particular interest in detecting the amount of contamination existing in the water solution for the media conditions. This methodology should provide us with the best possible sensitivity in monitoring water contaminant media characteristics. The results show that both methods, the hybrid voltage divider and the VNA methodology, are feasible in determining impedance modeling parameters. These parameters can be used to develop electric interrogation procedures and devices such as dielectric characteristics to identify contaminant substances in water solutions.

  7. Hybrid Lentivirus-transposon Vectors With a Random Integration Profile in Human Cells

    DEFF Research Database (Denmark)

    Staunstrup, Nicklas H; Moldt, Brian; Mátés, Lajos

    2009-01-01

    Gene delivery by human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors (LVs) is efficient, but genomic integration of the viral DNA is strongly biased toward transcriptionally active loci resulting in an increased risk of insertional mutagenesis in gene therapy protocols. Nonviral ...

  8. Hybrid cytomegalovirus-U6 promoter-based plasmid vectors improve efficiency of RNA interference in zebrafish.

    Science.gov (United States)

    Su, Jianguo; Zhu, Zuoyan; Xiong, Feng; Wang, Yaping

    2008-01-01

    Short hairpin RNA (shRNA) directed by RNA polymerase III (Pol III) or Pol II promoter was shown to be capable of silencing gene expression, which should permit analyses of gene functions or as a potential therapeutic tool. However, the inhibitory effect of shRNA remains problematic in fish. We demonstrated that silencing efficiency by shRNA produced from the hybrid construct composed of the CMV enhancer or entire CMV promoter placed immediately upstream of a U6 promoter. When tested the exogenous gene, silencing of an enhanced green fluorescent protein (EGFP) target gene was 89.18 +/- 5.06% for CMVE-U6 promoter group and 88.26 +/- 6.46% for CMV-U6 promoter group. To test the hybrid promoters driving shRNA efficiency against an endogenous gene, we used shRNA against no tail (NTL) gene. When vectorized in the zebrafish, the hybrid constructs strongly repressed NTL gene expression. The NTL phenotype occupied 52.09 +/- 3.06% and 51.56 +/- 3.68% for CMVE-U6 promoter and CMV-U6 promoter groups, respectively. The NTL gene expression reduced 82.17 +/- 2.96% for CMVE-U6 promoter group and 83.06 +/- 2.38% for CMV-U6 promoter group. We concluded that the CMV enhancer or entire CMV promoter locating upstream of the U6-promoter could significantly improve inhibitory effect induced by the shRNA for both exogenous and endogenous genes compared with the CMV promoter or U6 promoter alone. In contrast, the two hybrid promoter constructs had similar effects on driving shRNA.

  9. A Hybrid Sales Forecasting Scheme by Combining Independent Component Analysis with K-Means Clustering and Support Vector Regression

    Science.gov (United States)

    2014-01-01

    Sales forecasting plays an important role in operating a business since it can be used to determine the required inventory level to meet consumer demand and avoid the problem of under/overstocking. Improving the accuracy of sales forecasting has become an important issue of operating a business. This study proposes a hybrid sales forecasting scheme by combining independent component analysis (ICA) with K-means clustering and support vector regression (SVR). The proposed scheme first uses the ICA to extract hidden information from the observed sales data. The extracted features are then applied to K-means algorithm for clustering the sales data into several disjoined clusters. Finally, the SVR forecasting models are applied to each group to generate final forecasting results. Experimental results from information technology (IT) product agent sales data reveal that the proposed sales forecasting scheme outperforms the three comparison models and hence provides an efficient alternative for sales forecasting. PMID:25045738

  10. A Hybrid Sales Forecasting Scheme by Combining Independent Component Analysis with K-Means Clustering and Support Vector Regression

    Directory of Open Access Journals (Sweden)

    Chi-Jie Lu

    2014-01-01

    Full Text Available Sales forecasting plays an important role in operating a business since it can be used to determine the required inventory level to meet consumer demand and avoid the problem of under/overstocking. Improving the accuracy of sales forecasting has become an important issue of operating a business. This study proposes a hybrid sales forecasting scheme by combining independent component analysis (ICA with K-means clustering and support vector regression (SVR. The proposed scheme first uses the ICA to extract hidden information from the observed sales data. The extracted features are then applied to K-means algorithm for clustering the sales data into several disjoined clusters. Finally, the SVR forecasting models are applied to each group to generate final forecasting results. Experimental results from information technology (IT product agent sales data reveal that the proposed sales forecasting scheme outperforms the three comparison models and hence provides an efficient alternative for sales forecasting.

  11. Operational Modal Identification of Time-Varying Structures via a Vector Multistage Recursive Approach in Hybrid Time and Frequency Domain

    Directory of Open Access Journals (Sweden)

    Si-Da Zhou

    2015-01-01

    Full Text Available Real-time estimation of modal parameters of time-varying structures can conduct an obvious contribution to some specific applications in structural dynamic area, such as health monitoring, damage detection, and vibration control; the recursive algorithm of modal parameter estimation supplies one of fundamentals for acquiring modal parameters in real-time. This paper presents a vector multistage recursive method of modal parameter estimation for time-varying structures in hybrid time and frequency domain, including stages of recursive estimation of time-dependent power spectra, frozen-time modal parameter estimation, recursive modal validation, and continuous-time estimation of modal parameters. An experimental example validates the proposed method finally.

  12. A Hybrid Segmentation Model based on Watershed and Gradient Vector Flow for the Detection of Brain Tumor

    Directory of Open Access Journals (Sweden)

    D. Jayadevappa

    2009-09-01

    Full Text Available Medical Image segmentation deals with segmentation of tumor in CT and MR images for improved quality in medical diagnosis. Geometric Vector Flow (GVF enhances the concave object extraction capability. However, it suffers from high computational requirement andsensitiveness to noise. This paper intends to combine watershed algorithm with GVF snake model to reduce the computational complexity, to improve the insensitiveness to noise, and capture range. Specifically, the image will be segmented firstly through watershed algorithm and then the edges produced will be the initial contour of GVF model. This enhances the tumor boundaries and tuning the regulating parameters of the GVF snake mode by couplingthe smoothness of the edge map obtained due to watershed algorithm. The proposed method is compared with recent hybrid segmentation algorithm based on watershed and balloon snake. Superiority of the proposed work is observed in terms of capture range, concave objectextraction capability, sensitivity to noise, computational complexity, and segmentation accuracy.

  13. Natural Mosquito-Pathogen Hybrid IgG4 Antibodies in Vector Borne Diseases: A Hypothesis

    Directory of Open Access Journals (Sweden)

    Berlin L. Londono-Renteria

    2016-09-01

    Full Text Available Chronic exposure to antigens may favor the production of IgG4 antibodies over other antibody types. Recent studies have shown that up to a 30% of normal human IgG4 is bi-specific and is able to recognize two antigens of different nature. A requirement for this specificity is the presence of both eliciting antigens in the same time and at the same place where the immune response is induced. During transmission of most vector-borne diseases, the pathogen is delivered to the vertebrate host along with the arthropod saliva during blood feeding and previous studies have shown the existence of IgG4 antibodies against mosquito salivary allergens. However, there is very little ongoing research or information available regarding IgG4 bi-specificity with regards to infectious disease, particularly during immune responses to vector-borne diseases such as malaria, filariasis or dengue virus infection. Here, we provide background information and present our hypothesis that IgG4 may not only be a useful tool to measure exposure to infected mosquito bites, but that these bi-specific antibodies may also play an important role in modulation of the immune response against malaria and other vector-borne diseases in endemic settings.

  14. Hybrid RGSA and Support Vector Machine Framework for Three-Dimensional Magnetic Resonance Brain Tumor Classification

    Directory of Open Access Journals (Sweden)

    R. Rajesh Sharma

    2015-01-01

    algorithm (RGSA. Support vector machines, over backpropagation network, and k-nearest neighbor are used to evaluate the goodness of classifier approach. The preliminary evaluation of the system is performed using 320 real-time brain MRI images. The system is trained and tested by using a leave-one-case-out method. The performance of the classifier is tested using the receiver operating characteristic curve of 0.986 (±002. The experimental results demonstrate the systematic and efficient feature extraction and feature selection algorithm to the performance of state-of-the-art feature classification methods.

  15. Integrating matrix solution of the hybrid state vector equations for beam vibration

    Science.gov (United States)

    Lehman, L. L.

    1982-01-01

    A simple, versatile, and efficient computational technique has been developed for dynamic analysis of linear elastic beam and rod type of structures. Moreover, the method provides a rather general solution approach for two-point boundary value problems that are described by a single independent spatial variable. For structural problems, the method is implemented by a mixed state vector formulation of the differential equations, combined with an integrating matrix solution procedure. Highly accurate solutions are easily achieved with this approach. Example solutions are given for beam vibration problems including discontinuous stiffness and mass parameters, elastic restraint boundary conditions, concentrated inertia loading, and rigid body modes

  16. Cervical cancer survival prediction using hybrid of SMOTE, CART and smooth support vector machine

    Science.gov (United States)

    Purnami, S. W.; Khasanah, P. M.; Sumartini, S. H.; Chosuvivatwong, V.; Sriplung, H.

    2016-04-01

    According to the WHO, every two minutes there is one patient who died from cervical cancer. The high mortality rate is due to the lack of awareness of women for early detection. There are several factors that supposedly influence the survival of cervical cancer patients, including age, anemia status, stage, type of treatment, complications and secondary disease. This study wants to classify/predict cervical cancer survival based on those factors. Various classifications methods: classification and regression tree (CART), smooth support vector machine (SSVM), three order spline SSVM (TSSVM) were used. Since the data of cervical cancer are imbalanced, synthetic minority oversampling technique (SMOTE) is used for handling imbalanced dataset. Performances of these methods are evaluated using accuracy, sensitivity and specificity. Results of this study show that balancing data using SMOTE as preprocessing can improve performance of classification. The SMOTE-SSVM method provided better result than SMOTE-TSSVM and SMOTE-CART.

  17. Satellite Fault Diagnosis Using Support Vector Machines Based on a Hybrid Voting Mechanism

    Directory of Open Access Journals (Sweden)

    Hong Yin

    2014-01-01

    Full Text Available The satellite fault diagnosis has an important role in enhancing the safety, reliability, and availability of the satellite system. However, the problem of enormous parameters and multiple faults makes a challenge to the satellite fault diagnosis. The interactions between parameters and misclassifications from multiple faults will increase the false alarm rate and the false negative rate. On the other hand, for each satellite fault, there is not enough fault data for training. To most of the classification algorithms, it will degrade the performance of model. In this paper, we proposed an improving SVM based on a hybrid voting mechanism (HVM-SVM to deal with the problem of enormous parameters, multiple faults, and small samples. Many experimental results show that the accuracy of fault diagnosis using HVM-SVM is improved.

  18. River flow prediction using hybrid models of support vector regression with the wavelet transform, singular spectrum analysis and chaotic approach

    Science.gov (United States)

    Baydaroğlu, Özlem; Koçak, Kasım; Duran, Kemal

    2017-03-01

    Prediction of water amount that will enter the reservoirs in the following month is of vital importance especially for semi-arid countries like Turkey. Climate projections emphasize that water scarcity will be one of the serious problems in the future. This study presents a methodology for predicting river flow for the subsequent month based on the time series of observed monthly river flow with hybrid models of support vector regression (SVR). Monthly river flow over the period 1940-2012 observed for the Kızılırmak River in Turkey has been used for training the method, which then has been applied for predictions over a period of 3 years. SVR is a specific implementation of support vector machines (SVMs), which transforms the observed input data time series into a high-dimensional feature space (input matrix) by way of a kernel function and performs a linear regression in this space. SVR requires a special input matrix. The input matrix was produced by wavelet transforms (WT), singular spectrum analysis (SSA), and a chaotic approach (CA) applied to the input time series. WT convolutes the original time series into a series of wavelets, and SSA decomposes the time series into a trend, an oscillatory and a noise component by singular value decomposition. CA uses a phase space formed by trajectories, which represent the dynamics producing the time series. These three methods for producing the input matrix for the SVR proved successful, while the SVR-WT combination resulted in the highest coefficient of determination and the lowest mean absolute error.

  19. A fragmented adeno-associated viral dual vector strategy for treatment of diseases caused by mutations in large genes leads to expression of hybrid transcripts

    Science.gov (United States)

    McClements, Michelle E.; Charbel Issa, Peter; Blouin, Véronique; MacLaren, Robert E.

    2017-01-01

    Objective Dual vector AAV systems are being utilised to enable gene therapy for disorders in which the disease gene is too large to fit into a single capsid. Fragmented adeno-associated viral (fAAV) vectors containing single inverted terminal repeat truncated transgenes have been considered as one such gene replacement strategy. Here we aim to add to the current understanding of the molecular mechanisms employed by fAAV dual vector systems. Methods Oversized (>8kb) transgene constructs containing ABCA4 coding sequence were packaged as truncated fragments <5kb in size into various AAV serotypes. In vitro transductions with these fAAV vector preparations were conducted with mRNA and protein expression products assessed by way of RT-PCR, qPCR and western blot techniques. Results Transductions with fAAV vector preparations yielded ABCA4 mRNA, but did not generate detectable levels of protein. Sequencing of the transcript population revealed the presence of full length ABCA4 CDS with additional hybrid ABCA4 variants, indicating truncated transgenes without regions of overlap were joining and forming stable hybrid transgenes. In contrast, an ABCA4 overlapping dual vector system (OV) with a defined complementary region generated only full length mRNA transcripts plus detectable ABCA4 protein. Conclusion Despite previous success shown with the fAAV approach, the lack of repeatability and identification of stable hybrid transcripts capable of protein production suggests there is more refinement required before considering this approach in a clinical setting. PMID:28239514

  20. A Structurally Simplified Hybrid Model of Genetic Algorithm and Support Vector Machine for Prediction of Chlorophyll a in Reservoirs

    Directory of Open Access Journals (Sweden)

    Jieqiong Su

    2015-04-01

    Full Text Available With decreasing water availability as a result of climate change and human activities, analysis of the influential factors and variation trends of chlorophyll a has become important to prevent reservoir eutrophication and ensure water supply safety. In this paper, a structurally simplified hybrid model of the genetic algorithm (GA and the support vector machine (SVM was developed for the prediction of monthly concentration of chlorophyll a in the Miyun Reservoir of northern China over the period from 2000 to 2010. Based on the influence factor analysis, the four most relevant influence factors of chlorophyll a (i.e., total phosphorus, total nitrogen, permanganate index, and reservoir storage were extracted using the method of feature selection with the GA, which simplified the model structure, making it more practical and efficient for environmental management. The results showed that the developed simplified GA-SVM model could solve nonlinear problems of complex system, and was suitable for the simulation and prediction of chlorophyll a with better performance in accuracy and efficiency in the Miyun Reservoir.

  1. Estimation of Curie temperature of manganite-based materials for magnetic refrigeration application using hybrid gravitational based support vector regression

    Science.gov (United States)

    Owolabi, Taoreed O.; Akande, Kabiru O.; Olatunji, Sunday O.; Alqahtani, Abdullah; Aldhafferi, Nahier

    2016-10-01

    Magnetic refrigeration (MR) technology stands a good chance of replacing the conventional gas compression system (CGCS) of refrigeration due to its unique features such as high efficiency, low cost as well as being environmental friendly. Its operation involves the use of magnetocaloric effect (MCE) of a magnetic material caused by application of magnetic field. Manganite-based material demonstrates maximum MCE at its magnetic ordering temperature known as Curie temperature (TC). Consequently, manganite-based material with TC around room temperature is essentially desired for effective utilization of this technology. The TC of manganite-based materials can be adequately altered to a desired value through doping with appropriate foreign materials. In order to determine a manganite with TC around room temperature and to circumvent experimental challenges therein, this work proposes a model that can effectively estimates the TC of manganite-based material doped with different materials with the aid of support vector regression (SVR) hybridized with gravitational search algorithm (GSA). Implementation of GSA algorithm ensures optimum selection of SVR hyper-parameters for improved performance of the developed model using lattice distortions as the descriptors. The result of the developed model is promising and agrees excellently with the experimental results. The outstanding estimates of the proposed model suggest its potential in promoting room temperature magnetic refrigeration through quick estimation of the effect of dopants on TC so as to obtain manganite that works well around the room temperature.

  2. Estimation of Curie temperature of manganite-based materials for magnetic refrigeration application using hybrid gravitational based support vector regression

    Directory of Open Access Journals (Sweden)

    Taoreed O. Owolabi

    2016-10-01

    Full Text Available Magnetic refrigeration (MR technology stands a good chance of replacing the conventional gas compression system (CGCS of refrigeration due to its unique features such as high efficiency, low cost as well as being environmental friendly. Its operation involves the use of magnetocaloric effect (MCE of a magnetic material caused by application of magnetic field. Manganite-based material demonstrates maximum MCE at its magnetic ordering temperature known as Curie temperature (TC. Consequently, manganite-based material with TC around room temperature is essentially desired for effective utilization of this technology. The TC of manganite-based materials can be adequately altered to a desired value through doping with appropriate foreign materials. In order to determine a manganite with TC around room temperature and to circumvent experimental challenges therein, this work proposes a model that can effectively estimates the TC of manganite-based material doped with different materials with the aid of support vector regression (SVR hybridized with gravitational search algorithm (GSA. Implementation of GSA algorithm ensures optimum selection of SVR hyper-parameters for improved performance of the developed model using lattice distortions as the descriptors. The result of the developed model is promising and agrees excellently with the experimental results. The outstanding estimates of the proposed model suggest its potential in promoting room temperature magnetic refrigeration through quick estimation of the effect of dopants on TC so as to obtain manganite that works well around the room temperature.

  3. Hybrid Feature Selection Based Weighted Least Squares Twin Support Vector Machine Approach for Diagnosing Breast Cancer, Hepatitis, and Diabetes

    Directory of Open Access Journals (Sweden)

    Divya Tomar

    2015-01-01

    Full Text Available There is a necessity for analysis of a large amount of data in many fields such as healthcare, business, industries, and agriculture. Therefore, the need of the feature selection (FS technique for the researchers is quite evident in many fields of science, especially in computer science. Furthermore, an effective FS technique that is best suited to a particular learning algorithm is of great help for the researchers. Hence, this paper proposes a hybrid feature selection (HFS based efficient disease diagnostic model for Breast Cancer, Hepatitis, and Diabetes. A HFS is an efficient method that combines the positive aspects of both Filter and Wrapper FS approaches. The proposed model adopts weighted least squares twin support vector machine (WLSTSVM as a classification approach, sequential forward selection (SFS as a search strategy, and correlation feature selection (CFS to evaluate the importance of each feature. This model not only selects relevant feature subset but also efficiently deals with the data imbalance problem. The effectiveness of the HFS based WLSTSVM approach is examined on three well-known disease datasets taken from UCI repository with the help of predictive accuracy, sensitivity, specificity, and geometric mean. The experiment confirms that our proposed HFS based WLSTSVM disease diagnostic model can result in positive outcomes.

  4. Hybrid three-dimensional and support vector machine approach for automatic vehicle tracking and classification using a single camera

    Science.gov (United States)

    Kachach, Redouane; Cañas, José María

    2016-05-01

    Using video in traffic monitoring is one of the most active research domains in the computer vision community. TrafficMonitor, a system that employs a hybrid approach for automatic vehicle tracking and classification on highways using a simple stationary calibrated camera, is presented. The proposed system consists of three modules: vehicle detection, vehicle tracking, and vehicle classification. Moving vehicles are detected by an enhanced Gaussian mixture model background estimation algorithm. The design includes a technique to resolve the occlusion problem by using a combination of two-dimensional proximity tracking algorithm and the Kanade-Lucas-Tomasi feature tracking algorithm. The last module classifies the shapes identified into five vehicle categories: motorcycle, car, van, bus, and truck by using three-dimensional templates and an algorithm based on histogram of oriented gradients and the support vector machine classifier. Several experiments have been performed using both real and simulated traffic in order to validate the system. The experiments were conducted on GRAM-RTM dataset and a proper real video dataset which is made publicly available as part of this work.

  5. Transfer of primer binding site-mutated simian immunodeficiency virus vectors by genetically engineered artificial and hybrid tRNA-like primers

    DEFF Research Database (Denmark)

    Hansen, A C; Grunwald, T; Lund, Anders Henrik

    2001-01-01

    could be obtained by cotransfection of a gene for an engineered tRNA(Pro)-tRNA hybrid with a match to PBS-Pro. The importance of tRNA backbone identity was further analyzed by complementing the PBS-X2 vector with a gene for a matching x2 primer with a tRNA backbone, which led to three- to fourfold...

  6. Hybrid retroviral vector with MCK enhancers inserted in LTR for stable and specific expression of human factor IX in skeletal muscle

    Institute of Scientific and Technical Information of China (English)

    WANG Jian-min 王健民; HOU Jun 侯军; QIU Xin-fang 邱信芳; Kurachi Kotoku; XUE Jing-lun 薛京伦

    2004-01-01

    Background Retroviral vectors have been widely used to introduce foreign into various target cells in vitro, thus showing relatively high systemic delivery efficiency of various transgene products. The authors investigated the stability and efficiency of skeletal muscle-specific hybrid retroviral vectors in expression of human factor IX (FIX) in vitro and iv vivo. Methods FIX cDNA in LIXSN vector was replaced with a FIX minigene containing splicing donor and splicing acceptor sequence of first intron of human FIX gene. Two copies of muscle creatine kinase enhancer (MCK, Me2) were inserted in forward or reverse orientation at NheI site of 3' long terminal repeat (LTR), resulting in two hybrid vectors, which were designated as LMe2IXm2SN(F) and LMe2IXm2SN(R), respectively. The vectors were tested in vitro and in vivo for stability and muscle-specificity of factor IX expression with SCID mice. Results Muscle cells carrying vector with Me2 expressed significantly higher levels of FIX (up to 1800 ng/106.24h) than those without Me2, thus suggesting that Me2 could specifically increase expression level of FIX in muscle cells. Myoblasts transduced with LMe2IXm2SN(R) produced much less FIX in vivo in SCID mice than LMe2IXm2SN(F). One or two copies of Me2 sequence were deleted in myoblasts transduced with LMe2IXm2SN(R) without changing the orientation of Me2. Conclusions LTR inserted with MCK enhancers can specifically increase human FIX expression in skeletal muscle cells in vitro and in vivo, and MCK enhancer should be positioned in the same orientation as that of LTR promoter.

  7. A hybrid hierarchical approach for brain tissue segmentation by combining brain atlas and least square support vector machine.

    Science.gov (United States)

    Kasiri, Keyvan; Kazemi, Kamran; Dehghani, Mohammad Javad; Helfroush, Mohammad Sadegh

    2013-10-01

    In this paper, we present a new semi-automatic brain tissue segmentation method based on a hybrid hierarchical approach that combines a brain atlas as a priori information and a least-square support vector machine (LS-SVM). The method consists of three steps. In the first two steps, the skull is removed and the cerebrospinal fluid (CSF) is extracted. These two steps are performed using the toolbox FMRIB's automated segmentation tool integrated in the FSL software (FSL-FAST) developed in Oxford Centre for functional MRI of the brain (FMRIB). Then, in the third step, the LS-SVM is used to segment grey matter (GM) and white matter (WM). The training samples for LS-SVM are selected from the registered brain atlas. The voxel intensities and spatial positions are selected as the two feature groups for training and test. SVM as a powerful discriminator is able to handle nonlinear classification problems; however, it cannot provide posterior probability. Thus, we use a sigmoid function to map the SVM output into probabilities. The proposed method is used to segment CSF, GM and WM from the simulated magnetic resonance imaging (MRI) using Brainweb MRI simulator and real data provided by Internet Brain Segmentation Repository. The semi-automatically segmented brain tissues were evaluated by comparing to the corresponding ground truth. The Dice and Jaccard similarity coefficients, sensitivity and specificity were calculated for the quantitative validation of the results. The quantitative results show that the proposed method segments brain tissues accurately with respect to corresponding ground truth.

  8. Cationic lipid-nanoceria hybrids, a novel nonviral vector-mediated gene delivery into mammalian cells: investigation of the cellular uptake mechanism.

    Science.gov (United States)

    Das, Joydeep; Han, Jae Woong; Choi, Yun-Jung; Song, Hyuk; Cho, Ssang-Goo; Park, Chankyu; Seo, Han Geuk; Kim, Jin-Hoi

    2016-07-06

    Gene therapy is a promising technique for the treatment of various diseases. The development of minimally toxic and highly efficient non-viral gene delivery vectors is the most challenging undertaking in the field of gene therapy. Here, we developed dimethyldioctadecylammonium bromide (DODAB)-nanoceria (CeO2) hybrids as a new class of non-viral gene delivery vectors. These DODAB-modified CeO2 nanoparticles (CeO2/DODAB) could effectively compact the pDNA, allowing for highly efficient gene transfection into the selected cell lines. The CeO2/DODAB nanovectors were also found to be non-toxic and did not induce ROS formation as well as any stress responsive and pro-survival signaling pathways. The overall vector performance of CeO2/DODAB nanohybrids was comparable with lipofectamine and DOTAP, and higher than calcium phosphate and DEAE-dextran for transfecting small plasmids. The increased cellular uptake of the nanovector/DNA complexes through clathrin- and caveolae-mediated endocytosis and subsequent release from the endosomes further support the increased gene transfection efficiency of the CeO2/DODAB vectors. Besides, CeO2/DODAB nanovectors could transfect genes in vivo without any sign of toxicity. Taken together, this new nano-vector has the potential to be used for gene delivery in biomedical applications.

  9. Moving from pixels to parcels: Modeling agricultural scenarios in the northern Great Plains using a hybrid raster- and vector-based approach

    Science.gov (United States)

    Sohl, T.; Wika, S.; Dornbierer, J.; Sayler, K. L.; Quenzer, R.

    2015-12-01

    Policy and economic driving forces have resulted in a higher demand for biofuel feedstocks in recent years, resulting in substantial increases in cultivated cropland in the northern Great Plains. A cellulosic-based biofuel industry could potentially further impact the region, with grassland and marginal agricultural land converted to perennial grasses or other feedstocks. Scenarios of projected land-use change are needed to enable regional stakeholders to plan for the potential consequences of expanded agricultural activity. Land-use models used to produce spatially explicit scenarios are typically raster-based and are poor at representing ownership units on which land-use change is based. This work describes a hybrid raster/vector-based modeling approach for modeling scenarios of agricultural change in the northern Great Plains. Regional scenarios of agricultural change from 2012 to 2050 were constructed, based partly on the U.S. Department of Energy's Billion Ton Update. Land-use data built from the 2012 Cropland Data Layer and the 2011 National Land Cover Database was used to establish initial conditions. Field boundaries from the U.S. Department of Agriculture's Common Land Unit dataset were used to establish ownership units. A modified version of the U.S. Geological Survey's Forecasting Scenarios of land-use (FORE-SCE) model was used to ingest vector-based field boundaries to facilitate the modeling of a farmer's choice of land use for a given year, while patch-based raster methodologies were used to represent expansion of urban/developed lands and other land use conversions. All modeled data were merged to a common raster dataset representing annual land use from 2012 to 2050. The hybrid modeling approach enabled the use of traditional, raster-based methods while integrating vector-based data to represent agricultural fields and other ownership-based units upon which land-use decisions are typically made.

  10. Hybrid support vector regression and autoregressive integrated moving average models improved by particle swarm optimization for property crime rates forecasting with economic indicators.

    Science.gov (United States)

    Alwee, Razana; Shamsuddin, Siti Mariyam Hj; Sallehuddin, Roselina

    2013-01-01

    Crimes forecasting is an important area in the field of criminology. Linear models, such as regression and econometric models, are commonly applied in crime forecasting. However, in real crimes data, it is common that the data consists of both linear and nonlinear components. A single model may not be sufficient to identify all the characteristics of the data. The purpose of this study is to introduce a hybrid model that combines support vector regression (SVR) and autoregressive integrated moving average (ARIMA) to be applied in crime rates forecasting. SVR is very robust with small training data and high-dimensional problem. Meanwhile, ARIMA has the ability to model several types of time series. However, the accuracy of the SVR model depends on values of its parameters, while ARIMA is not robust to be applied to small data sets. Therefore, to overcome this problem, particle swarm optimization is used to estimate the parameters of the SVR and ARIMA models. The proposed hybrid model is used to forecast the property crime rates of the United State based on economic indicators. The experimental results show that the proposed hybrid model is able to produce more accurate forecasting results as compared to the individual models.

  11. Hybrid Support Vector Regression and Autoregressive Integrated Moving Average Models Improved by Particle Swarm Optimization for Property Crime Rates Forecasting with Economic Indicators

    Directory of Open Access Journals (Sweden)

    Razana Alwee

    2013-01-01

    Full Text Available Crimes forecasting is an important area in the field of criminology. Linear models, such as regression and econometric models, are commonly applied in crime forecasting. However, in real crimes data, it is common that the data consists of both linear and nonlinear components. A single model may not be sufficient to identify all the characteristics of the data. The purpose of this study is to introduce a hybrid model that combines support vector regression (SVR and autoregressive integrated moving average (ARIMA to be applied in crime rates forecasting. SVR is very robust with small training data and high-dimensional problem. Meanwhile, ARIMA has the ability to model several types of time series. However, the accuracy of the SVR model depends on values of its parameters, while ARIMA is not robust to be applied to small data sets. Therefore, to overcome this problem, particle swarm optimization is used to estimate the parameters of the SVR and ARIMA models. The proposed hybrid model is used to forecast the property crime rates of the United State based on economic indicators. The experimental results show that the proposed hybrid model is able to produce more accurate forecasting results as compared to the individual models.

  12. Trypanosoma cruzi genotypes of insect vectors and patients with Chagas of Chile studied by means of cytochrome b gene sequencing, minicircle hybridization, and nuclear gene polymorphisms.

    Science.gov (United States)

    Arenas, Marco; Campos, Ricardo; Coronado, Ximena; Ortiz, Sylvia; Solari, Aldo

    2012-03-01

    Fifty-six Trypanosoma cruzi stocks from Chile and neighboring countries and different hosts, humans, and Triatoma infestans and Mepraia sp., vectors of domiciliary and natural environments were characterized by using three molecular markers. These were cytochrome b (Cyt b) gene sequencing, minicircle DNA blotting, and hybridization with five genotype-specific DNA probes and nuclear analysis of 1f8 and gp72 by polymerase chain reaction-restriction fragment length polymorphism. The results with all three molecular markers are concordant, with minor limitations, grouping T. cruzi stocks into four discrete typing units (DTUs) (TcI, TcII, TcV, and TcVI). TcI and TcII stocks were heterogeneous. TcI and TcII stocks were clustered in two main subgroups determined by Cyt b gene sequencing and minicircle hybridization. However, TcV and TcVI stocks were homogeneous and not differentiated by Cyt b gene sequencing or minicircle DNA hybridization. The discriminatory power and limitations of the molecular markers are discussed, as well as the distribution of the four DTUs in the domiciliary and sylvatic transmission cycles of Chile and the limitations of each marker for molecular epidemiological studies performed with T. cruzi stocks rather than the analysis of direct T. cruzi samples from natural hosts.

  13. Construction and Identification of a Yeast Two-Hybrid Bait Vector and Its Effect on the Growth of Yeast Cells and the Self-Activating Function of Reporter Genes for Screening of HPV18 E6-Interacting Protein

    Institute of Scientific and Technical Information of China (English)

    梅泉; 李双; 刘萍; 奚玲; 王世宣; 孟玉菡; 刘杰; 杨欣慰; 卢运萍; 汪辉

    2010-01-01

    By using a yeast two-hybrid system,a yeast two-hybrid bait vector was constructed and identified for screening of the HPV18 E6-interacting proteins,and its effects on the growth of yeast cells and the activation of reporter genes were investigated.Total mRNA extracted from Hela cells was reversely transcribed into cDNA.Fragment of HPV18 E6 cDNA was amplified using RT-PCR and directly ligated to the pGBKT7 vector.The recombinant plasmid was confirmed by restriction endonuclease analysis and DNA sequencing.Th...

  14. A Hybrid Support Vector Machines and Two-dimensional Risk Matrix Model for Supply Chain Risk Assessment

    OpenAIRE

    Fan Jiang; Junfei Chen

    2014-01-01

    In recent years, the supply chain managements have been paid more and more attention. The supply chain risk management is an important content for enterprises implementing supply chain management. Therefore, how to measure the risk of supply chain is quite important. In this study, a supply chain risk evaluation model based on support vector machines and two-dimensional risk matrix is proposed. The index system of supply chain risk assessment which includes 14 indices is established. The case...

  15. Forecasting hysteresis behaviours of magnetorheological elastomer base isolator utilizing a hybrid model based on support vector regression and improved particle swarm optimization

    Science.gov (United States)

    Yu, Yang; Li, Yancheng; Li, Jianchun

    2015-03-01

    Due to its inherent hysteretic characteristics, the main challenge for the application of a magnetorheological elastomer- (MRE) based isolator is the exploitation of the accurate model, which could fully describe its unique behaviour. This paper proposes a nonparametric model for a MRE-based isolator based on support vector regression (SVR). The trained identification model is to forecast the shear force of the MRE-based isolator online; thus, the dynamic response from the MRE-based isolator can be well captured. In order to improve the forecast capacity of the model, a type of improved particle swarm optimization (IPSO) is employed to optimize the parameters in SVR. Eventually, the trained model is applied to the MRE-based isolator modelling with testing data. The results indicate that the proposed hybrid model has a better generalization capacity and better recognition accuracy than other conventional models, and it is an effective and suitable approach for forecasting the behaviours of a MRE-based isolator.

  16. Natural Mosquito-Pathogen Hybrid IgG4 Antibodies in Vector-Borne Diseases: A Hypothesis

    Science.gov (United States)

    Londono-Renteria, Berlin; Cardenas, Jenny C.; Troupin, Andrea; Colpitts, Tonya M.

    2016-01-01

    Chronic exposure to antigens may favor the production of IgG4 antibodies over other antibody types. Recent studies have shown that up to a 30% of normal human IgG4 is bi-specific and is able to recognize two antigens of different nature. A requirement for this specificity is the presence of both eliciting antigens in the same time and at the same place where the immune response is induced. During transmission of most vector-borne diseases, the pathogen is delivered to the vertebrate host along with the arthropod saliva during blood feeding and previous studies have shown the existence of IgG4 antibodies against mosquito salivary allergens. However, there is very little ongoing research or information available regarding IgG4 bi-specificity with regard to infectious disease, particularly during immune responses to vector-borne diseases, such as malaria, filariasis, or dengue virus infection. Here, we provide background information and present our hypothesis that IgG4 may not only be a useful tool to measure exposure to infected mosquito bites, but that these bi-specific antibodies may also play an important role in modulation of the immune response against malaria and other vector-borne diseases in endemic settings. PMID:27746778

  17. Hybrid lentivirus-phiC31-int-NLS vector allows site-specific recombination in murine and human cells but induces DNA damage.

    Directory of Open Access Journals (Sweden)

    Nicolas Grandchamp

    Full Text Available Gene transfer allows transient or permanent genetic modifications of cells for experimental or therapeutic purposes. Gene delivery by HIV-derived lentiviral vector (LV is highly effective but the risk of insertional mutagenesis is important and the random/uncontrollable integration of the DNA vector can deregulate the cell transcriptional activity. Non Integrative Lentiviral Vectors (NILVs solve this issue in non-dividing cells, but they do not allow long term expression in dividing cells. In this context, obtaining stable expression while avoiding the problems inherent to unpredictable DNA vector integration requires the ability to control the integration site. One possibility is to use the integrase of phage phiC31 (phiC31-int which catalyzes efficient site-specific recombination between the attP site in the phage genome and the chromosomal attB site of its Streptomyces host. Previous studies showed that phiC31-int is active in many eukaryotic cells, such as murine or human cells, and directs the integration of a DNA substrate into pseudo attP sites (pattP which are homologous to the native attP site. In this study, we combined the efficiency of NILV for gene delivery and the specificity of phiC31-int for DNA substrate integration to engineer a hybrid tool for gene transfer with the aim of allowing long term expression in dividing and non-dividing cells preventing genotoxicity. We demonstrated the feasibility to target NILV integration in human and murine pattP sites with a dual NILV vectors system: one which delivers phiC31-int, the other which constitute the substrate containing an attB site in its DNA sequence. These promising results are however alleviated by the occurrence of significant DNA damages. Further improvements are thus required to prevent chromosomal rearrangements for a therapeutic use of the system. However, its use as a tool for experimental applications such as transgenesis is already applicable.

  18. A Hybrid Support Vector Machines and Two-dimensional Risk Matrix Model for Supply Chain Risk Assessment

    Directory of Open Access Journals (Sweden)

    Fan Jiang

    2014-03-01

    Full Text Available In recent years, the supply chain managements have been paid more and more attention. The supply chain risk management is an important content for enterprises implementing supply chain management. Therefore, how to measure the risk of supply chain is quite important. In this study, a supply chain risk evaluation model based on support vector machines and two-dimensional risk matrix is proposed. The index system of supply chain risk assessment which includes 14 indices is established. The case study shows that the proposed model is reasonable, effective and it can provide an important reference for supply chain risk management.

  19. A Hybrid Approach of Stepwise Regression, Logistic Regression, Support Vector Machine, and Decision Tree for Forecasting Fraudulent Financial Statements

    Directory of Open Access Journals (Sweden)

    Suduan Chen

    2014-01-01

    Full Text Available As the fraudulent financial statement of an enterprise is increasingly serious with each passing day, establishing a valid forecasting fraudulent financial statement model of an enterprise has become an important question for academic research and financial practice. After screening the important variables using the stepwise regression, the study also matches the logistic regression, support vector machine, and decision tree to construct the classification models to make a comparison. The study adopts financial and nonfinancial variables to assist in establishment of the forecasting fraudulent financial statement model. Research objects are the companies to which the fraudulent and nonfraudulent financial statement happened between years 1998 to 2012. The findings are that financial and nonfinancial information are effectively used to distinguish the fraudulent financial statement, and decision tree C5.0 has the best classification effect 85.71%.

  20. Applying support vector machine on hybrid fNIRS/EEG signal to classify driver's conditions (Conference Presentation)

    Science.gov (United States)

    Nguyen, Thien; Ahn, Sangtae; Jang, Hyojung; Jun, Sung C.; Kim, Jae G.

    2016-03-01

    Driver's condition plays a critical role in driving safety. The fact that about 20 percent of automobile accidents occurred due to driver fatigue leads to a demand for developing a method to monitor driver's status. In this study, we acquired brain signals such as oxy- and deoxyhemoglobin and neuronal electrical activity by a hybrid fNIRS/EEG system. Experiments were conducted with 11 subjects under two conditions: Normal condition, when subjects had enough sleep, and sleep deprivation condition, when subject did not sleep previous night. During experiment, subject performed a driving task with a car simulation system for 30 minutes. After experiment, oxy-hemoglobin and deoxy-hemoglobin changes were derived from fNIRS data, while beta and alpha band relative power were calculated from EEG data. Decrement of oxy-hemoglobin, beta band power, and increment of alpha band power were found in sleep deprivation condition compare to normal condition. These features were then applied to classify two conditions by Fisher's linear discriminant analysis (FLDA). The ratio of alpha-beta relative power showed classification accuracy with a range between 62% and 99% depending on a subject. However, utilization of both EEG and fNIRS features increased accuracy in the range between 68% and 100%. The highest increase of accuracy is from 63% using EEG to 99% using both EEG and fNIRS features. In conclusion, the enhancement of classification accuracy is shown by adding a feature from fNIRS to the feature from EEG using FLDA which provides the need of developing a hybrid fNIRS/EEG system.

  1. Prediction of Pressure Drop of Slurry Flow in Pipeline by Hybrid Support Vector Regression and Genetic Algorithm Model%基于SVR-GA模型的浆态管流压力差的预测

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    This paper describes a robust support vector regression (SVR) methodology, which can offer superior performance for important process engineering problems. The method incorporates hybrid support vector regression and genetic algorithm technique (SVR-GA) for efficient tuning of SVR mcta-parameters. The algorithm has been applied for prediction of pressure drop of solid liquid slurry flow. A comparison with selected correlations in the literature showed that the developed SVR correlation noticeably improved the prediction of pressure drop over a wide range of operating conditions, physical properties, and pipe diameters.

  2. A hybrid model of support vector regression with genetic algorithm for forecasting adsorption of malachite green onto multi-walled carbon nanotubes: central composite design optimization.

    Science.gov (United States)

    Ghaedi, M; Dashtian, K; Ghaedi, A M; Dehghanian, N

    2016-05-11

    The aim of this work is the study of the predictive ability of a hybrid model of support vector regression with genetic algorithm optimization (GA-SVR) for the adsorption of malachite green (MG) onto multi-walled carbon nanotubes (MWCNTs). Various factors were investigated by central composite design and optimum conditions was set as: pH 8, 0.018 g MWCNTs, 8 mg L(-1) dye mixed with 50 mL solution thoroughly for 10 min. The Langmuir, Freundlich, Temkin and D-R isothermal models are applied to fitting the experimental data, and the data was well explained by the Langmuir model with a maximum adsorption capacity of 62.11-80.64 mg g(-1) in a short time at 25 °C. Kinetic studies at various adsorbent dosages and the initial MG concentration show that maximum MG removal was achieved within 10 min of the start of every experiment under most conditions. The adsorption obeys the pseudo-second-order rate equation in addition to the intraparticle diffusion model. The optimal parameters (C of 0.2509, σ(2) of 0.1288 and ε of 0.2018) for the SVR model were obtained based on the GA. For the testing data set, MSE values of 0.0034 and the coefficient of determination (R(2)) values of 0.9195 were achieved.

  3. Introducing Vectors.

    Science.gov (United States)

    Roche, John

    1997-01-01

    Suggests an approach to teaching vectors that promotes active learning through challenging questions addressed to the class, as opposed to subtle explanations. Promotes introducing vector graphics with concrete examples, beginning with an explanation of the displacement vector. Also discusses artificial vectors, vector algebra, and unit vectors.…

  4. 混合策略超球支持向量机算法%An Hyper-sphere Support Vector Machine with Hybrid Decision Strategy

    Institute of Scientific and Technical Information of China (English)

    刘爽; 陈鹏; 李克秋

    2014-01-01

    In order to solve classification problem of the intersections for multi-class classification based on hyper-sphere support vector machines ,a hybrid decision strategy is put forward in this paper .First ,characteristics of data distribution in the intersections are analyzed and then decision class is decided by different strategies .If training samples of two classes in the intersection can be classified by intersection hyper-plane for two hyper-spheres ,then new test samples can be decided by this plane . If training samples of two classes in the intersection can be approximately linearly classified ,new test samples can be classified by standard optimal binary-SVM hyper-plane .If training samples of two classes in the intersection can not be linearly classified ,new test samples can be decided by introducing kernel function to get optimal classification hyper-plane .If training examples belong to only one class , then new test samples can be classified by exclusion method . Experimental results show performance of our algorithm is more optimal than hyper-sphere support vector machines with only one decision strategy .And this algorithm improves the performance and decreases computation complexity .%针对多类别分类超球支持向量机算法的重叠区域数据分类问题,提出了一种混合策略决策算法。首先对超球相交区域的数据分布情况分析得到数据分布的特点,然后根据数据分布特点采用不同的决策策略。如果用两球相交面直接可以把两类数据分开,则直接用相交面作为分类平面。如果两类数据近似线性可分,构造最优二分超平面作为分类平面。如果两类数据非线性可分,则引入核函数构造最优二分超平面为分类球面。如果相交区域只包含一个类别的数据,则采用排它法作为测试样本的决策规则。实验结果表明所提出的算法性能优于单一决策策略的超球支持向量机算法,在提高分类

  5. The Neural Support Vector Machine

    NARCIS (Netherlands)

    Wiering, Marco; van der Ree, Michiel; Embrechts, Mark; Stollenga, Marijn; Meijster, Arnold; Nolte, A; Schomaker, Lambertus

    2013-01-01

    This paper describes a new machine learning algorithm for regression and dimensionality reduction tasks. The Neural Support Vector Machine (NSVM) is a hybrid learning algorithm consisting of neural networks and support vector machines (SVMs). The output of the NSVM is given by SVMs that take a

  6. The Neural Support Vector Machine

    NARCIS (Netherlands)

    Wiering, Marco; van der Ree, Michiel; Embrechts, Mark; Stollenga, Marijn; Meijster, Arnold; Nolte, A; Schomaker, Lambertus

    2013-01-01

    This paper describes a new machine learning algorithm for regression and dimensionality reduction tasks. The Neural Support Vector Machine (NSVM) is a hybrid learning algorithm consisting of neural networks and support vector machines (SVMs). The output of the NSVM is given by SVMs that take a centr

  7. Vector grammars and PN machines

    Institute of Scientific and Technical Information of China (English)

    蒋昌俊

    1996-01-01

    The concept of vector grammars under the string semantic is introduced.The dass of vector grammars is given,which is similar to the dass of Chomsky grammars.The regular vector grammar is divided further.The strong and weak relation between the vector grammar and scalar grammar is discussed,so the spectrum system graph of scalar and vector grammars is made.The equivalent relation between the regular vector grammar and Petri nets (also called PN machine) is pointed.The hybrid PN machine is introduced,and its language is proved equivalent to the language of the context-free vector grammar.So the perfect relation structure between vector grammars and PN machines is formed.

  8. A Mathematical Approach to Hybridization

    Science.gov (United States)

    Matthews, P. S. C.; Thompson, J. J.

    1975-01-01

    Presents an approach to hybridization which exploits the similarities between the algebra of wave functions and vectors. This method will account satisfactorily for the number of orbitals formed when applied to hybrids involving the s and p orbitals. (GS)

  9. About vectors

    CERN Document Server

    Hoffmann, Banesh

    1975-01-01

    From his unusual beginning in ""Defining a vector"" to his final comments on ""What then is a vector?"" author Banesh Hoffmann has written a book that is provocative and unconventional. In his emphasis on the unresolved issue of defining a vector, Hoffmann mixes pure and applied mathematics without using calculus. The result is a treatment that can serve as a supplement and corrective to textbooks, as well as collateral reading in all courses that deal with vectors. Major topics include vectors and the parallelogram law; algebraic notation and basic ideas; vector algebra; scalars and scalar p

  10. Vector analysis

    CERN Document Server

    Newell, Homer E

    2006-01-01

    When employed with skill and understanding, vector analysis can be a practical and powerful tool. This text develops the algebra and calculus of vectors in a manner useful to physicists and engineers. Numerous exercises (with answers) not only provide practice in manipulation but also help establish students' physical and geometric intuition in regard to vectors and vector concepts.Part I, the basic portion of the text, consists of a thorough treatment of vector algebra and the vector calculus. Part II presents the illustrative matter, demonstrating applications to kinematics, mechanics, and e

  11. A Financial Risk Premonition Model Based on the Hybrid Orthogonal Genetic Algorithm for Global Optimization and Support Vector Machine%混合HOGA-SVM财务风险预警模型实证研究

    Institute of Scientific and Technical Information of China (English)

    丁德臣

    2011-01-01

    目前涉及遗传算法与支持向量机相结合的预测模型中,遗传算法基本上采用的是标准算法.但是在对全局函数的优化中,一般的遗传算法容易陷入局部最优,从而降低遗传算法收敛速度和搜索精度,进而影响财务风险预警模型的精度与速度.基于此,提出了基于混合全局优化正交遗传算法(HOGA)和支持向量机(SVM)的财务风险预警模型(HOGA-SVM),通过使用混合全局优化正交遗传算法连同支持向量机来改进支持向量机进行财务风险预警的效果.结果显示,提出的模型不仅提高了财务风险预警的准确率和速度,而且模型的两类分类错误率(尤其是第一类分类错误率)相对其他模型也有了明显下降.未来的工作可以把模型的应用扩大到多分类的财务风险预警问题中.%Financial risk premonition can exert a significant influence on a company's survival and growth. Many financial risk premonition models generally fall into two categories: the traditional statistics model and the Al model. A hybrid model that incorporates hybrid genetic algorithms and support vector machines ( SVM ) is becoming an important financial risk promotion model.The simple genetic algorithm is frequently used in the hybrid financial risk premonition model. However, convergence rate has a weak performance in the optimization of multi-objective functions. A financial risk premonition model based on the hybrid orthogonal genetic algorithm for global optimization and support vector machine (HOGA-SVM) is proposed to improve the effect of financial risk premonition.HOGA is used to optimize both subset features and SVM parameters simultaneously. The optimization process includes five steps" ( 1 ) encode subset features and SVM parameters. The chromosomes of SVM parameters are encoded as a 16-bit string that consists of 8 bits standing for C and the other 8 bits standing for. The chromosomes of subset features were further encoded as

  12. Elementary vectors

    CERN Document Server

    Wolstenholme, E Œ

    1978-01-01

    Elementary Vectors, Third Edition serves as an introductory course in vector analysis and is intended to present the theoretical and application aspects of vectors. The book covers topics that rigorously explain and provide definitions, principles, equations, and methods in vector analysis. Applications of vector methods to simple kinematical and dynamical problems; central forces and orbits; and solutions to geometrical problems are discussed as well. This edition of the text also provides an appendix, intended for students, which the author hopes to bridge the gap between theory and appl

  13. Comment on "A hybrid model of self organizing maps and least square support vector machine for river flow forecasting" by Ismail et al. (2012)

    Science.gov (United States)

    Fahimi, F.; El-Shafie, A. H.

    2014-07-01

    Without a doubt, river flow forecasting is one of the most important issues in water engineering field. There are lots of forecasting techniques that have successfully been utilized by previously conducted studies in water resource management and water engineering. The study of Ismail et al. (2012), which was published in the journal Hydrology and Earth System Sciences in 2012, was a valuable piece of research that investigated the combination of two effective methods (self-organizing map and least squares support vector machine) for river flow forecasting. The goal was to make a comparison between the performances of self organizing map and least square support vector machine (SOM-LSSVM), autoregressive integrated moving average (ARIMA), artificial neural network (ANN) and least squares support vector machine (LSSVM) models for river flow prediction. This comment attempts to focus on some parts of the original paper that need more discussion. The emphasis here is to provide more information about the accuracy of the observed river flow data and the optimum map size for SOM mode as well.

  14. Vector analysis

    CERN Document Server

    Brand, Louis

    2006-01-01

    The use of vectors not only simplifies treatments of differential geometry, mechanics, hydrodynamics, and electrodynamics, but also makes mathematical and physical concepts more tangible and easy to grasp. This text for undergraduates was designed as a short introductory course to give students the tools of vector algebra and calculus, as well as a brief glimpse into these subjects' manifold applications. The applications are developed to the extent that the uses of the potential function, both scalar and vector, are fully illustrated. Moreover, the basic postulates of vector analysis are brou

  15. Hybrid polypeptides having cellobiohydrolase activity and polynucleotides encoding same

    Science.gov (United States)

    Liu, Ye; Shaghasi, Tarana

    2016-11-01

    The present invention provides hybrid polypeptides having cellobiohydrolase activity. The present invention also provides polynucleotides encoding the hybrid polypeptides; nucleic acid constructs, vectors and host cells comprising the polynucleotides; and processes of using the hybrid polypeptides.

  16. Cloning vector

    Science.gov (United States)

    Guilfoyle, R.A.; Smith, L.M.

    1994-12-27

    A vector comprising a filamentous phage sequence containing a first copy of filamentous phage gene X and other sequences necessary for the phage to propagate is disclosed. The vector also contains a second copy of filamentous phage gene X downstream from a promoter capable of promoting transcription in a bacterial host. In a preferred form of the present invention, the filamentous phage is M13 and the vector additionally includes a restriction endonuclease site located in such a manner as to substantially inactivate the second gene X when a DNA sequence is inserted into the restriction site. 2 figures.

  17. Cloning vector

    Science.gov (United States)

    Guilfoyle, Richard A.; Smith, Lloyd M.

    1994-01-01

    A vector comprising a filamentous phage sequence containing a first copy of filamentous phage gene X and other sequences necessary for the phage to propagate is disclosed. The vector also contains a second copy of filamentous phage gene X downstream from a promoter capable of promoting transcription in a bacterial host. In a preferred form of the present invention, the filamentous phage is M13 and the vector additionally includes a restriction endonuclease site located in such a manner as to substantially inactivate the second gene X when a DNA sequence is inserted into the restriction site.

  18. Parallel Sparse Matrix - Vector Product

    DEFF Research Database (Denmark)

    Alexandersen, Joe; Lazarov, Boyan Stefanov; Dammann, Bernd

    This technical report contains a case study of a sparse matrix-vector product routine, implemented for parallel execution on a compute cluster with both pure MPI and hybrid MPI-OpenMP solutions. C++ classes for sparse data types were developed and the report shows how these class can be used...

  19. Parallel Sparse Matrix - Vector Product

    DEFF Research Database (Denmark)

    Alexandersen, Joe; Lazarov, Boyan Stefanov; Dammann, Bernd

    This technical report contains a case study of a sparse matrix-vector product routine, implemented for parallel execution on a compute cluster with both pure MPI and hybrid MPI-OpenMP solutions. C++ classes for sparse data types were developed and the report shows how these class can be used...

  20. Immobilized Lentivirus Vector on Chondroitin Sulfate-Hyaluronate Acid-Silk Fibroin Hybrid Scaffold for Tissue-Engineered Ligament-Bone Junction

    Directory of Open Access Journals (Sweden)

    Liguo Sun

    2014-01-01

    Full Text Available The lack of a fibrocartilage layer between graft and bone remains the leading cause of graft failure after anterior cruciate ligament (ACL reconstruction. The objective of this study was to develop a gene-modified silk cable-reinforced chondroitin sulfate-hyaluronate acid-silk fibroin (CHS hybrid scaffold for reconstructing the fibrocartilage layer. The scaffold was fabricated by lyophilizing the CHS mixture with braided silk cables. The scanning electronic microscopy (SEM showed that microporous CHS sponges were formed around silk cables. Each end of scaffold was modified with lentiviral-mediated transforming growth factor-β3 (TGF-β3 gene. The cells on scaffold were transfected by bonded lentivirus. In vitro culture demonstrated that mesenchymal stem cells (MSCs on scaffolds proliferated vigorously and produced abundant collagen. The transcription levels of cartilage-specific genes also increased with culture time. After 2 weeks, the MSCs were distributed uniformly throughout scaffold. Deposited collagen was also found to increase. The chondral differentiation of MSCs was verified by expressions of collagen II and TGF-β3 genes in mRNA and protein level. Histology also confirmed the production of cartilage extracellular matrix (ECM components. The results demonstrated that gene-modified silk cable-reinforced CHS scaffold was capable of supporting cell proliferation and differentiation to reconstruct the cartilage layer of interface.

  1. Ad Hoc on-Demand Distance Vector (AODV Routing Protocol Performance Evaluation on Hybrid Ad Hoc Network: Comparison of Result of Ns-2 Simulation and Implementation on Testbed using PDA

    Directory of Open Access Journals (Sweden)

    Riri Sari

    2010-10-01

    Full Text Available In Mobile Ad hoc NETwork (MANET, node supplemented with wireless equipment has the capacity to manage and organise autonomously, without the presence of network infrastructures. Hybrid ad hoc network, enable several nodes to move freely (mobile to create instant communication. Independent from infrastructure. They could access the Local Area Network (LAN or the Internet. Functionalities of ad hoc network very much dependent on the routing protocol that determines the routing around node. Ad hoc On-demand Distance Vector (AODV is one of routing protocols in ad hoc network which has a reactive characteristic. This protocol is the most common protocol being researched and used. In this Research, AODV protocol investigation was conducted by developing a testbed using Personal Computer, several Laptops (the Linux Red Hat operation system 9.0 and Fedora Core 2, and Personal Digital Assistant (PDA. This research also made a complete package by mean of cross compilation for PDA iPAQ. In general, results obtained from the simulation of AODV protocol using Network Simulator NS-2 are packet delivery ratio 99.89%, end-to-end delay of 0.14 seconds and routing overhead of 1,756.61 byte per second. Afterwards results from simulation were compared to results from testbed. Results obtained from testbed are as follows: the packet delivery ratio is 99.57%, the end-to-end delay is 1.004 seconds and the routing overhead is 1,360.36 byte per second.

  2. Vector geometry

    CERN Document Server

    Robinson, Gilbert de B

    2011-01-01

    This brief undergraduate-level text by a prominent Cambridge-educated mathematician explores the relationship between algebra and geometry. An elementary course in plane geometry is the sole requirement for Gilbert de B. Robinson's text, which is the result of several years of teaching and learning the most effective methods from discussions with students. Topics include lines and planes, determinants and linear equations, matrices, groups and linear transformations, and vectors and vector spaces. Additional subjects range from conics and quadrics to homogeneous coordinates and projective geom

  3. A Space Vector Pulse Width Modulation Based Optimization Control Strategy for Hybrid Cascaded 7-Level Inverter%基于SVPWM调制的混合级联七电平逆变器优化控制策略

    Institute of Scientific and Technical Information of China (English)

    耿俊利; 梁晖; 金渊

    2015-01-01

    The working modes of hybrid cascaded 7-level inverter with dead zone are analyzed and analysis results show that there are different jumping situations of inverter voltage under different working modes. On this basis, based on space vector pulse width modulation (SVPWM) strategy an optimal control method is proposed. In the premise that the supporting capacitor voltage is under the control, through analyzing the jumping of output voltage level and the valve action times corresponding to the charging/discharging process of supporting capacity voltage switching in each interval an optimal control strategy to reduce the jumping of output voltage is put forward; besides, the output voltage loss due to the existence of dead zone time is analyzed and calculated according to the principle of volt-second balance, and the dead zone compensation for its modulation wave is performed. The effectiveness of the proposed control strategy is validated by results of simulation and experiments.%分析混合级联七电平逆变器带死区时的工作模式,不同工作模式下其逆变器电压的跳变情况不同。在此基础上,提出了基于空间矢量脉冲调制(space vector pulse width modulation,SVPWM)策略的优化控制方法。以控制支撑电容电压为前提,通过对每个区间支撑电容充放电切换过程所对应的开关动作次数、输出电压电平跳变情况的分析,提出了一种减小输出电压跳变的优化控制策略;此外,分析了死区时间的存在所带来的输出电压损失,根据伏秒平衡原理进行计算,并对其调制波进行死区补偿。仿真及实验结果验证了该控制策略的有效性。

  4. Biodegradable charged polyester-based vectors (BCPVs) as an efficient non-viral transfection nanoagent for gene knockdown of the BCR-ABL hybrid oncogene in a human chronic myeloid leukemia cell line

    Science.gov (United States)

    Yang, Chengbin; Panwar, Nishtha; Wang, Yucheng; Zhang, Butian; Liu, Maixian; Toh, Huiting; Yoon, Ho Sup; Tjin, Swee Chuan; Chong, Peter Han Joo; Law, Wing-Cheung; Chen, Chih-Kuang; Yong, Ken-Tye

    2016-04-01

    First-line therapy of chronic myelogenous leukemia (CML) has always involved the use of BCR-ABL tyrosine-kinase inhibitors which is associated with an abnormal chromosome called Philadelphia chromosome. Although the overall survival rate has been improved by the current therapeutic regime, the presence of resistance has resulted in limited efficacy. In this study, an RNA interference (RNAi)-based therapeutic regime is proposed with the aim to knockdown the BCR-ABL hybrid oncogene using small interfering RNA (siRNA). The siRNA transfection rates have usually been limited due to the declining contact probability among polyplexes and the non-adherent nature of leukemic cells. Our work aims at addressing this limitation by using a biodegradable charged polyester-based vector (BCPV) as a nanocarrier for the delivery of BCR-ABL-specific siRNA to the suspension culture of a K562 CML cell line. BCR-ABL siRNAs were encapsulated in the BCPVs by electrostatic force. Cell internalization was facilitated by the BCPV and assessed by confocal microscopy and flow cytometry. The regulation of the BCR-ABL level in K562 cells as a result of RNAi was analyzed by real-time polymerase chain reaction (RT-PCR). We observed that BCPV was able to form stable nanoplexes with siRNA molecules, even in the presence of fetal bovine serum (FBS), and successfully assisted in vitro siRNA transfection in the non-adherent K562 cells. As a consequence of downregulation of BCR-ABL, BCPV-siRNA nanoplexes inhibited cell proliferation and promoted cell apoptosis. All results were compared with a commercial transfection reagent, Lipofectamine2000™, which served as a positive control. More importantly, this class of non-viral vector exhibits biodegradable features and negligible cytotoxicity, thus providing a versatile platform to deliver siRNA to non-adherent leukemia cells with high transfection efficiency by effectively overcoming extra- and intra-cellular barriers. Due to the excellent in vitro

  5. Vector velocimeter

    DEFF Research Database (Denmark)

    2012-01-01

    The present invention relates to a compact, reliable and low-cost vector velocimeter for example for determining velocities of particles suspended in a gas or fluid flow, or for determining velocity, displacement, rotation, or vibration of a solid surface, the vector velocimeter comprising a laser...... assembly for emission of a measurement beam for illumination of an object in a measurement volume with coherent light whereby a signal beam emanating from the object in the measurement volume is formed in response to illumination of the object by the measurement beam, a reference beam generator...... detector element signal when the fringe pattern formed by the interfering signal beam and reference beam moves across the first detector array; and a signal processor that is adapted for generation of a velocity signal corresponding to a first velocity component of movement of the object in the measurement...

  6. Vector velocimeter

    DEFF Research Database (Denmark)

    2012-01-01

    for generation of a reference beam, a detector system comprising a first detector arrangement arranged in such a way that the signal beam and the reference beam are incident upon the first detector arrangement with the reference beam propagating at an angle relative to a signal beam, and wherein the first......The present invention relates to a compact, reliable and low-cost vector velocimeter for example for determining velocities of particles suspended in a gas or fluid flow, or for determining velocity, displacement, rotation, or vibration of a solid surface, the vector velocimeter comprising a laser...... assembly for emission of a measurement beam for illumination of an object in a measurement volume with coherent light whereby a signal beam emanating from the object in the measurement volume is formed in response to illumination of the object by the measurement beam, a reference beam generator...

  7. Vector nematicons

    CERN Document Server

    Horikis, Theodoros P

    2016-01-01

    Families of soliton pairs, namely vector solitons, are found within the context of a coupled nonlocal nonlinear Schrodinger system of equations, as appropriate for modeling beam propagation in nematic liquid crystals. In the focusing case, bright soliton pairs have been found to exist provided their amplitudes satisfy a specific condition. In our analytical approach, focused on the defocusing regime, we rely on a multiscale expansion methods, which reveals the existence of dark-dark and antidark-antidark solitons, obeying an effective Korteweg-de Vries equation, as well as dark-bright solitons, obeying an effective Mel'nikov system. These pairs are discriminated by the sign of a constant that links all physical parameters of the system to the amplitude of the stable continuous wave solutions, and, much like the focusing case, the solitons' amplitudes are linked leading to mutual guiding.

  8. Rotations with Rodrigues' Vector

    Science.gov (United States)

    Pina, E.

    2011-01-01

    The rotational dynamics was studied from the point of view of Rodrigues' vector. This vector is defined here by its connection with other forms of parametrization of the rotation matrix. The rotation matrix was expressed in terms of this vector. The angular velocity was computed using the components of Rodrigues' vector as coordinates. It appears…

  9. Enhanced performance hybrid-arq

    KAUST Repository

    Fareed, Muhammad Mehboob

    2016-06-16

    Apparatuses, computer readable media, and methods are provided for enhancing hybrid automatic repeat request (ARQ) performance. In an example method, a communication device transmits a first element of a vector, where the vector is selected using the information bits to be transmitted as an index in a code book. In some embodiments, this code book is constructed using Linear Constellation Precoding (LCP). If a NACK is received, the communication device transmits a second element of the vector. The process of transmitting elements of the vector continues until an ACK is received or the maximum number of transmission attempts is reached. If an ACK is received, the communication device transmits a first element of another vector of the code book that encodes a second set of information bits. This procedure may continue until all information bits have been transmitted successfully.

  10. Concise vector analysis

    CERN Document Server

    Eliezer, C J; Maxwell, E A; Sneddon, I N

    1963-01-01

    Concise Vector Analysis is a five-chapter introductory account of the methods and techniques of vector analysis. These methods are indispensable tools in mathematics, physics, and engineering. The book is based on lectures given by the author in the University of Ceylon.The first two chapters deal with vector algebra. These chapters particularly present the addition, representation, and resolution of vectors. The next two chapters examine the various aspects and specificities of vector calculus. The last chapter looks into some standard applications of vector algebra and calculus.This book wil

  11. Light axial vector mesons

    CERN Document Server

    Chen, Kan; Liu, Xiang; Matsuki, Takayuki

    2015-01-01

    Inspired by the abundant experimental observation of axial vector states, we study whether the observed axial vector states can be categorized into the conventional axial vector meson family. In this paper we carry out analysis based on the mass spectra and two-body Okubo-Zweig-Iizuka-allowed decays. Besides testing the possible axial vector meson assignments, we also predict abundant information for their decays and the properties of some missing axial vector mesons, which are valuable to further experimental exploration of the observed and predicted axial vector mesons.

  12. Hybrid Baryons

    CERN Document Server

    Page, P R

    2003-01-01

    We review the status of hybrid baryons. The only known way to study hybrids rigorously is via excited adiabatic potentials. Hybrids can be modelled by both the bag and flux-tube models. The low-lying hybrid baryon is N 1/2^+ with a mass of 1.5-1.8 GeV. Hybrid baryons can be produced in the glue-rich processes of diffractive gamma N and pi N production, Psi decays and p pbar annihilation.

  13. VectorBase

    Data.gov (United States)

    U.S. Department of Health & Human Services — VectorBase is a Bioinformatics Resource Center for invertebrate vectors. It is one of four Bioinformatics Resource Centers funded by NIAID to provide web-based...

  14. On Double Vector Bundles

    Institute of Scientific and Technical Information of China (English)

    Zhuo CHEN; Zhang Ju LIU; Yun He SHENG

    2014-01-01

    In this paper, we construct a category of short exact sequences of vector bundles and prove that it is equivalent to the category of double vector bundles. Moreover, operations on double vector bundles can be transferred to operations on the corresponding short exact sequences. In particular, we study the duality theory of double vector bundles in term of the corresponding short exact sequences. Examples including the jet bundle and the Atiyah algebroid are discussed.

  15. On Double Vector Bundles

    OpenAIRE

    Chen, Zhuo; Liu, Zhangju; Sheng, Yunhe

    2011-01-01

    In this paper, we construct a category of short exact sequences of vector bundles and prove that it is equivalent to the category of double vector bundles. Moreover, operations on double vector bundles can be transferred to operations on the corresponding short exact sequences. In particular, we study the duality theory of double vector bundles in term of the corresponding short exact sequences. Examples including the jet bundle and the Atiyah algebroid are discussed.

  16. Custodial vector model

    DEFF Research Database (Denmark)

    Becciolini, Diego; Franzosi, Diogo Buarque; Foadi, Roshan;

    2015-01-01

    We analyze the Large Hadron Collider (LHC) phenomenology of heavy vector resonances with a $SU(2)_L\\times SU(2)_R$ spectral global symmetry. This symmetry partially protects the electroweak S-parameter from large contributions of the vector resonances. The resulting custodial vector model spectrum...

  17. Custodial vector model

    DEFF Research Database (Denmark)

    Becciolini, Diego; Franzosi, Diogo Buarque; Foadi, Roshan

    2015-01-01

    We analyze the Large Hadron Collider (LHC) phenomenology of heavy vector resonances with a $SU(2)_L\\times SU(2)_R$ spectral global symmetry. This symmetry partially protects the electroweak S-parameter from large contributions of the vector resonances. The resulting custodial vector model spectrum...

  18. Personal credit scoring based on hybrid support vector machines with cluster analysis%基于聚类和支持向量机的个人信誉评估方法

    Institute of Scientific and Technical Information of China (English)

    刘夫成; 高尚

    2013-01-01

    There are some problems exist in traditional individual credit assessment system. To solve those problems, a credit assessment model basesed on k-means method and support vector method is proposed. First the training samples are clustered using the K-means method. Then, the new samples defined according the feature of samples in cluster train the support vector machines, and to classify the test set by SVM. The result shows the approach improves training precision and test precision of the whole model compared with the traditional support vector classification method and improved the training speed.%针对传统的个人信誉评估方法存在的缺陷,提出了一种基于K均值聚类和支持向量机结合的个人信誉评估方法.该方法先将测试数据集进行聚类,根据数据离聚类的数据分布来选取合适数据训练支持向量机,然后利用支持向量机进行分类.结果表明,同单一利用支持向量机分类进行比较,该方法减少了训练时间,同时具有较高的测试精度,比传统的个人信誉评估模型有更好的效果.

  19. Construction, expression and identification of yeast two-hybrid bait vector pGBKT7-tH of peste des petits ruminants virus%小反刍兽疫病毒酵母双杂交诱饵载体pGBKT7-tH的构建、表达和鉴定

    Institute of Scientific and Technical Information of China (English)

    蒙学莲; 朱学亮; 翟军军; 窦永喜; 才学鹏

    2011-01-01

    The fragment of tH was amplified by PCR,and was cloned into the bait expression vector pGBKT7. After being verified by restriction digestion and sequencing, the bait vector was transformed into yeast cells AH109. The toxicity,leakage and self-transcriptional activation of PPRV-tH protein were firstly detected. Then the expression of was analyzed by Western blotting. Results showed that PPRV-tH was amplified and cloned into pGBKT7 successfully. The bait protein vector was transformed into AH109 as well and the toxicity,leakage and self- transcriptional activation of PPRV-tH protein were not observed. The PPRV-tH protein could be effectively expressed in transformed yeast. It plays a critical part in works of screening receptor gene by yeast two-hybrid system.%利用PCR技术扩增获得PPRV-tH基因片段,将其克隆至酵母双杂交系统诱饵载体pGBKT7中,经酶切、测序验证其正确插入后,将重组诱饵质粒转化酵母菌AH109中,检测其在酵母中有无渗漏、自我激活作用和毒性.利用western blotting分析诱饵蛋白在酵母中的表达情况,以鉴定其作为诱饵蛋白的可行性.结果表明,成功扩增到了PPRV-tH,并正确构建了pGBKT7-tH诱饵表达载体,此载体在酵母细胞AH109中无毒性、渗漏和自我激活能力,且能正确表达tH蛋白.

  20. Hybrid vehicles

    Energy Technology Data Exchange (ETDEWEB)

    West, J.G.W. [Electrical Machines (United Kingdom)

    1997-07-01

    The reasons for adopting hybrid vehicles result mainly from the lack of adequate range from electric vehicles at an acceptable cost. Hybrids can offer significant improvements in emissions and fuel economy. Series and parallel hybrids are compared. A combination of series and parallel operation would be the ideal. This can be obtained using a planetary gearbox as a power split device allowing a small generator to transfer power to the propulsion motor giving the effect of a CVT. It allows the engine to run at semi-constant speed giving better fuel economy and reduced emissions. Hybrid car developments are described that show the wide range of possible hybrid systems. (author)

  1. Vector Soliton Fiber Lasers

    CERN Document Server

    Zhang, Han

    2011-01-01

    Solitons, as stable localized wave packets that can propagate long distance in dispersive media without changing their shapes, are ubiquitous in nonlinear physical systems. Since the first experimental realization of optical bright solitons in the anomalous dispersion single mode fibers (SMF) by Mollenauer et al. in 1980 and optical dark solitons in the normal dispersion SMFs by P. Emplit et al. in 1987, optical solitons in SMFs had been extensively investigated. In reality a SMF always supports two orthogonal polarization modes. Taking fiber birefringence into account, it was later theoretically predicted that various types of vector solitons, including the bright-bright vector solitons, dark-dark vector solitons and dark-bright vector solitons, could be formed in SMFs. However, except the bright-bright type of vector solitons, other types of vector solitons are so far lack of clear experimental evidence. Optical solitons have been observed not only in the SMFs but also in mode locked fiber lasers. It has be...

  2. 人星状病毒非结构蛋白酵母双杂交诱饵表达载体构建及酵母转化子特性鉴定%Construction of Yeast Two-Hybrid Bait Vector of HAstV Non-Struc-tural Protein and Characterization of Yeast Transformants

    Institute of Scientific and Technical Information of China (English)

    李攀; 崔成成; 杨思达; 黄芬; 曾韦锟; 井申荣

    2014-01-01

    Objective To construct a yeast two-hybrid bait vector of non-structure protein 1a/3 (nsP1a/3) of human astrovirus (HAstV), and to characterize the yeast transformants after elec-trotransformation of the recombinant plasmid into the yeast competent cells .Methods The coding sequence of HAstV nsP 1 a/3 obtained by PCR was inserted into the modified plasmid pGST 7.The re-combinant vector nsP1a/3-pGBST7 confirmed by DNA sequencing was transformed into the Y 2 HGo-ld yeast competent cells .The cytotoxicity of the expression products of the recombiant plasmid nsP1a/3-pGBST7 and the autoactivation of the report gene in yeast transformants were exam-ined.Results The sequencing of the nsP 1 a/3-pGBST7 vector showed that the recombinant bait plasmid was successfully constructed and the open reading frame of nsP 1a/3 insert was correct.After electrotransformation, it was found that the expression products of the nsP 1a/3-pGBST7 vector had no cytotoxicity to yeast transformants and also they did not activate the report gene .Conclusion The yeast two-hybrid bait vector of HAstV nsP 1 a/3 was successfully constructed , which laid a foun-dation for further studying the interaction of HAstV nsP 1 a/3 with target proteins and the replication mechanism of HAstV in host cells .%目的:构建人星状病毒非结构蛋白3( non-structure protein 1a/3, nsP1a/3)基因酵母双杂交诱饵重组质粒,电转化酵母感受态细胞后鉴定酵母转化子特性。方法聚合酶链反应扩增人星状病毒nsP1a/3编码的基因序列,定向插入到穿梭表达载体pGBKT7改造后的pGBST7中,测序确定无误后将其电转化到Y2HGold酵母感受态细胞中,对细胞特性即nsP1a/3-pGBST7诱饵质粒表达产物的毒性和报告基因自激活作用进行鉴定。结果测序结果表明诱饵重组质粒构建正确,阅读框无误。电转化酵母后,其表达产物对酵母细胞无毒性作用,对报告基因亦无激活作用。结论成功构建了

  3. Vehicle Based Vector Sensor

    Science.gov (United States)

    2015-09-28

    300001 1 of 16 VEHICLE-BASED VECTOR SENSOR STATEMENT OF GOVERNMENT INTEREST [0001] The invention described herein may be manufactured and...unmanned underwater vehicle that can function as an acoustic vector sensor . (2) Description of the Prior Art [0004] It is known that a propagating...mechanics. An acoustic vector sensor measures the particle motion via an accelerometer and combines Attorney Docket No. 300001 2 of 16 the

  4. Implicit Real Vector Automata

    Directory of Open Access Journals (Sweden)

    Jean-François Degbomont

    2010-10-01

    Full Text Available This paper addresses the symbolic representation of non-convex real polyhedra, i.e., sets of real vectors satisfying arbitrary Boolean combinations of linear constraints. We develop an original data structure for representing such sets, based on an implicit and concise encoding of a known structure, the Real Vector Automaton. The resulting formalism provides a canonical representation of polyhedra, is closed under Boolean operators, and admits an efficient decision procedure for testing the membership of a vector.

  5. Vectors and their applications

    CERN Document Server

    Pettofrezzo, Anthony J

    2005-01-01

    Geared toward undergraduate students, this text illustrates the use of vectors as a mathematical tool in plane synthetic geometry, plane and spherical trigonometry, and analytic geometry of two- and three-dimensional space. Its rigorous development includes a complete treatment of the algebra of vectors in the first two chapters.Among the text's outstanding features are numbered definitions and theorems in the development of vector algebra, which appear in italics for easy reference. Most of the theorems include proofs, and coordinate position vectors receive an in-depth treatment. Key concept

  6. Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...... or meromorphic (allowing poles as singularities) functions. There already exists a well-developed theory for iterative holomorphic dynamical systems, and successful relations found between iteration theory and flows of vector fields have been one of the main motivations for the recent interest in holomorphic...

  7. Full Gradient Solution to Adaptive Hybrid Control

    Science.gov (United States)

    Bean, Jacob; Schiller, Noah H.; Fuller, Chris

    2017-01-01

    This paper focuses on the adaptation mechanisms in adaptive hybrid controllers. Most adaptive hybrid controllers update two filters individually according to the filtered reference least mean squares (FxLMS) algorithm. Because this algorithm was derived for feedforward control, it does not take into account the presence of a feedback loop in the gradient calculation. This paper provides a derivation of the proper weight vector gradient for hybrid (or feedback) controllers that takes into account the presence of feedback. In this formulation, a single weight vector is updated rather than two individually. An internal model structure is assumed for the feedback part of the controller. The full gradient is equivalent to that used in the standard FxLMS algorithm with the addition of a recursive term that is a function of the modeling error. Some simulations are provided to highlight the advantages of using the full gradient in the weight vector update rather than the approximation.

  8. Robotic Pectoral Fin Thrust Vectoring Using Weighted Gait Combinations

    Directory of Open Access Journals (Sweden)

    John S. Palmisano

    2012-01-01

    Full Text Available A method was devised to vector propulsion of a robotic pectoral fin by means of actively controlling fin surface curvature. Separate flapping fin gaits were designed to maximize thrust for each of three different thrust vectors: forward, reverse, and lift. By using weighted combinations of these three pre-determined main gaits, new intermediate hybrid gaits for any desired propulsion vector can be created with smooth transitioning between these gaits. This weighted gait combination (WGC method is applicable to other difficult-to-model actuators. Both 3D unsteady computational fluid dynamics (CFD and experimental results are presented.

  9. Shuttle cloning vectors for the cyanobacterium Anacystis nidulans.

    OpenAIRE

    Gendel, S; Straus, N; Pulleyblank, D; Williams, J

    1983-01-01

    Hybrid plasmids capable of acting as shuttle cloning vectors in Escherichia coli and the cyanobacterium Anacystis nidulans R2 were constructed by in vitro ligation. DNA from the small endogenous plasmid of A. nidulans was combined with two E. coli vectors, pBR325 and pDPL13, to create vectors containing either two selectable antibiotic resistance markers or a single marker linked to a flexible multisite polylinker. Nonessential DNA was deleted from the polylinker containing plasmid pPLAN B2 t...

  10. Advancing vector biology research

    NARCIS (Netherlands)

    Kohl, Alain; Pondeville, Emilie; Schnettler, Esther; Crisanti, Andrea; Supparo, Clelia; Christophides, George K.; Kersey, Paul J.; Maslen, Gareth L.; Takken, Willem; Koenraadt, Constantianus J.M.; Oliva, Clelia F.; Busquets, Núria; Abad, F.X.; Failloux, Anna Bella; Levashina, Elena A.; Wilson, Anthony J.; Veronesi, Eva; Pichard, Maëlle; Arnaud Marsh, Sarah; Simard, Frédéric; Vernick, Kenneth D.

    2016-01-01

    Vector-borne pathogens impact public health, animal production, and animal welfare. Research on arthropod vectors such as mosquitoes, ticks, sandflies, and midges which transmit pathogens to humans and economically important animals is crucial for development of new control measures that target t

  11. Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    or meromorphic (allowing poles as singularities) functions. There already exists a well-developed theory for iterative holomorphic dynamical systems, and successful relations found between iteration theory and flows of vector fields have been one of the main motivations for the recent interest in holomorphic...... vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...... of parameter spaces into structurally stable domains, and a description of the bifurcations. For this reason, the talk will focus on these questions for complex polynomial vector fields....

  12. Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    The two branches of dynamical systems, continuous and discrete, correspond to the study of differential equations (vector fields) and iteration of mappings respectively. In holomorphic dynamics, the systems studied are restricted to those described by holomorphic (complex analytic) functions...... vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...... of parameter spaces into structurally stable domains, and a description of the bifurcations. For this reason, the talk will focus on these questions for complex polynomial vector fields....

  13. Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    The two branches of dynamical systems, continuous and discrete, correspond to the study of differential equations (vector fields) and iteration of mappings respectively. In holomorphic dynamics, the systems studied are restricted to those described by holomorphic (complex analytic) functions...... or meromorphic (allowing poles as singularities) functions. There already exists a well-developed theory for iterative holomorphic dynamical systems, and successful relations found between iteration theory and flows of vector fields have been one of the main motivations for the recent interest in holomorphic...... vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...

  14. DESIGNING A HYBRID INTELLIGENT MINING SYSTEM FOR CREDIT RISK EVALUATION

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In this study,a novel hybrid intelligent mining system integrating rough sets theory and support vector machines is developed to extract efficiently association rules from original information table for credit risk evaluation and analysis.In the proposed hybrid intelligent system,support vector machines are used as a tool to extract typical features and filter its noise,which are different from the previous studies where rough sets were only used as a preprocessor for support vector machines.Such an approach could reduce the information table and generate the final knowledge from the reduced information table by rough sets.Therefore,the proposed hybrid intelligent system overcomes the diffi-culty of extracting rules from a trained support vector machine classifier and possesses the robustness which is lacking for rough-set-based approaches.In addition,the effectiveness of the proposed hybrid intelligent system is illustrated with two real-world credit datasets.

  15. 猪瘟病毒酵母双杂交 pGBK T7-NS3诱饵载体的构建与鉴定%Construction and Identification of CSFV pGBKT7-NS3 Bait Vector in Yeast Two-hybrid System

    Institute of Scientific and Technical Information of China (English)

    宋江伟; 田宏; 吴锦艳; 陈妍; 尚佑军; 刘湘涛

    2014-01-01

    The NS3 gene of classical swine fever virus was amplified by RT-PCR and confirmed by sequen-cing and enzyme digestion .The NS3 gene was then subcloned into pGBKT7 to construct the bait vector ac-cording to the reading frame .The reconstructed bait vector pGBKT7-NS3 was transformed into Y2H Gold yeast strain ,its self-activation and toxic effect were tested by the phenotype assay .The expression of pG-BKT7-NS3 was analysed by Western blot .As a result ,the successfully reconstructed bait vector pGBKT7-NS3 would not self-activitate the reporter gene and had no toxic effect to the yeast ,which laid the founda-tion for using yeast two-hybrid assay to screen interaction proteins .%利用 RT-PCR技术扩增获得猪瘟病毒NS3基因片段,将其克隆至酵母双杂交系统诱饵载体pGBKT7中,经酶切,测序验证其正确插入后,将重组诱饵质粒转化酵母菌Y2H Gold ,检测其在酵母中毒性和自我激活作用,并利用Western blot分析诱饵载体在酵母中的转化情况。结果表明,pGBKT7-NS3诱饵载体在Y2H Gold酵母细胞中可以表达,此载体在酵母细胞Y2H Gold中无毒性和自我激活能力,研究结果为使用酵母双杂交技术筛选相互作用蛋白奠定了基础。

  16. ON VECTOR NETWORK EQUILIBRIUM PROBLEMS

    Institute of Scientific and Technical Information of China (English)

    Guangya CHEN

    2005-01-01

    In this paper we define a concept of weak equilibrium for vector network equilibrium problems.We obtain sufficient conditions of weak equilibrium points and establish relation with vector network equilibrium problems and vector variational inequalities.

  17. Light composite vector bosons

    CERN Document Server

    Kosower, David A.

    1993-01-01

    In gauge theories with slowly-running coupling constants, it may be possible for four-fermion operators to be nearly marginal. Such operators can possess asymptotically weak couplings, and can plausibly give rise to light composite vector mesons.

  18. GAP Land Cover - Vector

    Data.gov (United States)

    Minnesota Department of Natural Resources — This vector dataset is a detailed (1-acre minimum), hierarchically organized vegetation cover map produced by computer classification of combined two-season pairs of...

  19. Tagged Vector Contour (TVC)

    Data.gov (United States)

    Kansas Data Access and Support Center — The Kansas Tagged Vector Contour (TVC) dataset consists of digitized contours from the 7.5 minute topographic quadrangle maps. Coverage for the state is incomplete....

  20. Vector Lattice Vortex Solitons

    Institute of Scientific and Technical Information of China (English)

    WANG Jian-Dong; YE Fang-Wei; DONG Liang-Wei; LI Yong-Ping

    2005-01-01

    @@ Two-dimensional vector vortex solitons in harmonic optical lattices are investigated. The stability properties of such solitons are closely connected to the lattice depth Vo. For small Vo, vector vortex solitons with the total zero-angular momentum are more stable than those with the total nonzero-angular momentum, while for large Vo, this case is inversed. If Vo is large enough, both the types of such solitons are stable.

  1. Support vector machines applications

    CERN Document Server

    Guo, Guodong

    2014-01-01

    Support vector machines (SVM) have both a solid mathematical background and good performance in practical applications. This book focuses on the recent advances and applications of the SVM in different areas, such as image processing, medical practice, computer vision, pattern recognition, machine learning, applied statistics, business intelligence, and artificial intelligence. The aim of this book is to create a comprehensive source on support vector machine applications, especially some recent advances.

  2. The Vector Curvaton

    CERN Document Server

    Navarro, Andres A

    2013-01-01

    We analyze a massive vector field with a non-canonical kinetic term in the action, minimally coupled to gravity, where the mass and kinetic function of the vector field vary as functions of time during inflation. The vector field is introduced following the same idea of a scalar curvaton, which must not affect the inflationary dynamics since its energy density during inflation is negligible compared to the total energy density in the Universe. Using this hypothesis, the vector curvaton will be solely responsible for generating the primordial curvature perturbation \\zeta. We have found that the spectra of the vector field perturbations are scale-invariant in superhorizon scales due to the suitable choice of the time dependence of the kinetic function and the effective mass during inflation. The preferred direction, generated by the vector field, makes the spectrum of \\zeta depend on the wavevector, i.e. there exists statistical anisotropy in \\zeta. This is discussed principally in the case where the mass of th...

  3. Hybrid Metaheuristics

    CERN Document Server

    2013-01-01

    The main goal of this book is to provide a state of the art of hybrid metaheuristics. The book provides a complete background that enables readers to design and implement hybrid metaheuristics to solve complex optimization problems (continuous/discrete, mono-objective/multi-objective, optimization under uncertainty) in a diverse range of application domains. Readers learn to solve large scale problems quickly and efficiently combining metaheuristics with complementary metaheuristics, mathematical programming, constraint programming and machine learning. Numerous real-world examples of problems and solutions demonstrate how hybrid metaheuristics are applied in such fields as networks, logistics and transportation, bio-medical, engineering design, scheduling.

  4. Vector cross product in n-dimensional vector space

    OpenAIRE

    Tian, Xiu-Lao; Yang, Chao; Hu, Yang; Tian, Chao

    2013-01-01

    The definition of vector cross product (VCP) introduced by Eckmann only exists in thethree- and the seven- dimensional vector space. In this paper, according to the orthogonal completeness, magnitude of basis vector cross product and all kinds of combinations of basis vector $\\hat{e}_i$, the generalized definition of VCP in the odd n-dimensional vector space is given by introducing a cross term $X_{AB}$. In addition, the definition is validated by reducing the generalization definition to the...

  5. Hybrid intermediaries

    OpenAIRE

    Cetorelli, Nicola

    2014-01-01

    I introduce the concept of hybrid intermediaries: financial conglomerates that control a multiplicity of entity types active in the "assembly line" process of modern financial intermediation, a system that has become known as shadow banking. The complex bank holding companies of today are the best example of hybrid intermediaries, but I argue that financial firms from the "nonbank" space can just as easily evolve into conglomerates with similar organizational structure, thus acquiring the cap...

  6. Hybrid composites

    CSIR Research Space (South Africa)

    Jacob John, Maya

    2009-04-01

    Full Text Available effect was observed for the elongation at break of the hybrid composites. The impact strength of the hybrid composites increased with the addition of glass fibres. The tensile and impact properties of thermoplastic natural rubber reinforced short... panels made from conventional structural materials. Figure 3 illustrates the performance of cellular biocomposite panels against conventional systems used for building and residential construction, namely a pre- cast pre-stressed hollow core concrete...

  7. Extended Mixed Vector Equilibrium Problems

    Directory of Open Access Journals (Sweden)

    Mijanur Rahaman

    2014-01-01

    Full Text Available We study extended mixed vector equilibrium problems, namely, extended weak mixed vector equilibrium problem and extended strong mixed vector equilibrium problem in Hausdorff topological vector spaces. Using generalized KKM-Fan theorem (Ben-El-Mechaiekh et al.; 2005, some existence results for both problems are proved in noncompact domain.

  8. Bunyavirus-vector interactions.

    Science.gov (United States)

    Beaty, B J; Bishop, D H

    1988-06-01

    Recent advances in the genetics and molecular biology of bunyaviruses have been applied to understanding bunyavirus-vector interactions. Such approaches have revealed which virus gene and gene products are important in establishing infections in vectors and in transmission of viruses. However, much more information is required to understand the molecular mechanisms of persistent infections of vectors which are lifelong but apparently exert no untoward effect. In fact, it seems remarkable that LAC viral antigen can be detected in almost every cell in an ovarian follicle, yet no untoward effect on fecundity and no teratology is seen. Similarly the lifelong infection of the vector would seem to provide ample opportunity for bunyavirus evolution by genetic drift and, under the appropriate circumstances, by segment reassortment. The potential for bunyavirus evolution by segment reassortment in vectors certainly exists. For example the Group C viruses in a small forest in Brazil seem to constitute a gene pool, with the 6 viruses related alternately by HI/NT and CF reactions, which assay respectively M RNA and S RNA gene products (Casals and Whitman, 1960; Shope and Causey, 1962). Direct evidence for naturally occurring reassortant bunyaviruses has also been obtained. Oligonucleotide fingerprint analyses of field isolates of LAC virus and members of the Patois serogroup of bunyaviruses have demonstrated that reassortment does occur in nature (El Said et al., 1979; Klimas et al., 1981; Ushijima et al., 1981). Determination of the genotypic frequencies of viruses selected by the biological interactions of viruses and vectors after dual infection and segment reassortment is an important issue. Should a virus result that efficiently interacts with alternate vector species, the virus could be expressed in different circumstances with serious epidemiologic consequences. Dual infection of vectors with different viruses is not unlikely, because many bunyaviruses are sympatric in

  9. Scalable motion vector coding

    Science.gov (United States)

    Barbarien, Joeri; Munteanu, Adrian; Verdicchio, Fabio; Andreopoulos, Yiannis; Cornelis, Jan P.; Schelkens, Peter

    2004-11-01

    Modern video coding applications require transmission of video data over variable-bandwidth channels to a variety of terminals with different screen resolutions and available computational power. Scalable video coding is needed to optimally support these applications. Recently proposed wavelet-based video codecs employing spatial domain motion compensated temporal filtering (SDMCTF) provide quality, resolution and frame-rate scalability while delivering compression performance comparable to that of the state-of-the-art non-scalable H.264-codec. These codecs require scalable coding of the motion vectors in order to support a large range of bit-rates with optimal compression efficiency. Scalable motion vector coding algorithms based on the integer wavelet transform followed by embedded coding of the wavelet coefficients were recently proposed. In this paper, a new and fundamentally different scalable motion vector codec (MVC) using median-based motion vector prediction is proposed. Extensive experimental results demonstrate that the proposed MVC systematically outperforms the wavelet-based state-of-the-art solutions. To be able to take advantage of the proposed scalable MVC, a rate allocation mechanism capable of optimally dividing the available rate among texture and motion information is required. Two rate allocation strategies are proposed and compared. The proposed MVC and rate allocation schemes are incorporated into an SDMCTF-based video codec and the benefits of scalable motion vector coding are experimentally demonstrated.

  10. Vector Fields on Product Manifolds

    CERN Document Server

    Kurz, Stefan

    2011-01-01

    This short report establishes some basic properties of smooth vector fields on product manifolds. The main results are: (i) On a product manifold there always exists a direct sum decomposition into horizontal and vertical vector fields. (ii) Horizontal and vertical vector fields are naturally isomorphic to smooth families of vector fields defined on the factors. Vector fields are regarded as derivations of the algebra of smooth functions.

  11. Robustifying Vector Median Filter

    Directory of Open Access Journals (Sweden)

    Valentín Gregori

    2011-08-01

    Full Text Available This paper describes two methods for impulse noise reduction in colour images that outperform the vector median filter from the noise reduction capability point of view. Both methods work by determining first the vector median in a given filtering window. Then, the use of complimentary information from componentwise analysis allows to build robust outputs from more reliable components. The correlation among the colour channels is taken into account in the processing and, as a result, a more robust filter able to process colour images without introducing colour artifacts is obtained. Experimental results show that the images filtered with the proposed method contain less noisy pixels than those obtained through the vector median filter. Objective measures demonstrate the goodness of the achieved improvement.

  12. Boosting Support Vector Machines

    Directory of Open Access Journals (Sweden)

    Elkin Eduardo García Díaz

    2006-11-01

    Full Text Available En este artículo, se presenta un algoritmo de clasificación binaria basado en Support Vector Machines (Máquinas de Vectores de Soporte que combinado apropiadamente con técnicas de Boosting consigue un mejor desempeño en cuanto a tiempo de entrenamiento y conserva características similares de generalización con un modelo de igual complejidad pero de representación más compacta./ In this paper we present an algorithm of binary classification based on Support Vector Machines. It is combined with a modified Boosting algorithm. It run faster than the original SVM algorithm with a similar generalization error and equal complexity model but it has more compact representation.

  13. Scalar-Vector Bootstrap

    CERN Document Server

    Rejon-Barrera, Fernando

    2015-01-01

    We work out all of the details required for implementation of the conformal bootstrap program applied to the four-point function of two scalars and two vectors in an abstract conformal field theory in arbitrary dimension. This includes a review of which tensor structures make appearances, a construction of the projectors onto the required mixed symmetry representations, and a computation of the conformal blocks for all possible operators which can be exchanged. These blocks are presented as differential operators acting upon the previously known scalar conformal blocks. Finally, we set up the bootstrap equations which implement crossing symmetry. Special attention is given to the case of conserved vectors, where several simplifications occur.

  14. Scalar-vector bootstrap

    Energy Technology Data Exchange (ETDEWEB)

    Rejon-Barrera, Fernando [Institute for Theoretical Physics, University of Amsterdam,Science Park 904, Postbus 94485, 1090 GL, Amsterdam (Netherlands); Robbins, Daniel [Department of Physics, Texas A& M University,TAMU 4242, College Station, TX 77843 (United States)

    2016-01-22

    We work out all of the details required for implementation of the conformal bootstrap program applied to the four-point function of two scalars and two vectors in an abstract conformal field theory in arbitrary dimension. This includes a review of which tensor structures make appearances, a construction of the projectors onto the required mixed symmetry representations, and a computation of the conformal blocks for all possible operators which can be exchanged. These blocks are presented as differential operators acting upon the previously known scalar conformal blocks. Finally, we set up the bootstrap equations which implement crossing symmetry. Special attention is given to the case of conserved vectors, where several simplifications occur.

  15. Topological vector spaces

    CERN Document Server

    Narici, Lawrence

    2011-01-01

    BackgroundTopology Valuation Theory Algebra Linear Functionals Hyperplanes Measure Theory Normed SpacesCommutative Topological GroupsElementary ConsiderationsSeparation and Compactness Bases at 0 for Group Topologies Subgroups and Products Quotients S-Topologies Metrizability CompletenessCompleteness Function Groups Total BoundednessCompactness and Total Boundedness Uniform Continuity Extension of Uniformly Continuous Maps CompletionTopological Vector SpacesAbsorbent and Balanced Sets Convexity-AlgebraicBasic PropertiesConvexity-Topological Generating Vector Topologies A Non-Locally Convex Spa

  16. Matrix vector analysis

    CERN Document Server

    Eisenman, Richard L

    2005-01-01

    This outstanding text and reference applies matrix ideas to vector methods, using physical ideas to illustrate and motivate mathematical concepts but employing a mathematical continuity of development rather than a physical approach. The author, who taught at the U.S. Air Force Academy, dispenses with the artificial barrier between vectors and matrices--and more generally, between pure and applied mathematics.Motivated examples introduce each idea, with interpretations of physical, algebraic, and geometric contexts, in addition to generalizations to theorems that reflect the essential structur

  17. Free topological vector spaces

    OpenAIRE

    Gabriyelyan, Saak S.; Morris, Sidney A.

    2016-01-01

    We define and study the free topological vector space $\\mathbb{V}(X)$ over a Tychonoff space $X$. We prove that $\\mathbb{V}(X)$ is a $k_\\omega$-space if and only if $X$ is a $k_\\omega$-space. If $X$ is infinite, then $\\mathbb{V}(X)$ contains a closed vector subspace which is topologically isomorphic to $\\mathbb{V}(\\mathbb{N})$. It is proved that if $X$ is a $k$-space, then $\\mathbb{V}(X)$ is locally convex if and only if $X$ is discrete and countable. If $X$ is a metrizable space it is shown ...

  18. Duality in vector optimization

    CERN Document Server

    Bot, Radu Ioan

    2009-01-01

    This book presents fundamentals and comprehensive results regarding duality for scalar, vector and set-valued optimization problems in a general setting. After a preliminary chapter dedicated to convex analysis and minimality notions of sets with respect to partial orderings induced by convex cones a chapter on scalar conjugate duality follows. Then investigations on vector duality based on scalar conjugacy are made. Weak, strong and converse duality statements are delivered and connections to classical results from the literature are emphasized. One chapter is exclusively consecrated to the s

  19. Analysis in Vector Spaces

    CERN Document Server

    Akcoglu, Mustafa A; Ha, Dzung Minh

    2011-01-01

    A rigorous introduction to calculus in vector spaces The concepts and theorems of advanced calculus combined with related computational methods are essential to understanding nearly all areas of quantitative science. Analysis in Vector Spaces presents the central results of this classic subject through rigorous arguments, discussions, and examples. The book aims to cultivate not only knowledge of the major theoretical results, but also the geometric intuition needed for both mathematical problem-solving and modeling in the formal sciences. The authors begin with an outline of key concepts, ter

  20. Repulsive Vector Interaction in Three Flavor Magnetized Quark and Stellar Matter

    CERN Document Server

    Menezes, Débora P; Castro, Luis B; Costa, Pedro; Providência, Constan\\cca

    2014-01-01

    The effect of the vector interaction on three flavor magnetized matter is studied within the SU(3) Nambu--Jona-Lasiono quark model. We have considered cold matter under a static external magnetic field within two different models for the vector interaction in order to investigate how the form of the vector interaction and the intensity of the magnetic field affect the equation of state as well as the strangeness content. It was shown that the flavor independent vector interaction predicts a smaller strangeness content and, therefore, harder equations of state. On the other hand, the flavor dependent vector interaction favors larger strangeness content the larger the vector coupling. We have confirmed that at low densities the magnetic field and the vector interaction have opposite competing effects: the first one softens the equation of state while the second hardens it. Quark stars and hybrid stars subject to an external magnetic field were also studied. Larger star masses are obtained for the flavor indepen...

  1. Hybrid Noncoherent Network Coding

    CERN Document Server

    Skachek, Vitaly; Nedic, Angelia

    2011-01-01

    We describe a novel extension of subspace codes for noncoherent networks, suitable for use when the network is viewed as a communication system that introduces both dimension and symbol errors. We show that when symbol erasures occur in a significantly large number of different basis vectors transmitted through the network and when the min-cut of the networks is much smaller then the length of the transmitted codewords, the new family of codes outperforms their subspace code counterparts. For the proposed coding scheme, termed hybrid network coding, we derive two upper bounds on the size of the codes. These bounds represent a variation of the Singleton and of the sphere-packing bound. We show that a simple concatenated scheme that represents a combination of subspace codes and Reed-Solomon codes is asymptotically optimal with respect to the Singleton bound. Finally, we describe two efficient decoding algorithms for concatenated subspace codes that in certain cases have smaller complexity than subspace decoder...

  2. Estimation of vector velocity

    DEFF Research Database (Denmark)

    2000-01-01

    Using a pulsed ultrasound field, the two-dimensional velocity vector can be determined with the invention. The method uses a transversally modulated ultrasound field for probing the moving medium under investigation. A modified autocorrelation approach is used in the velocity estimation. The new...

  3. Vectors Point Toward Pisa

    Science.gov (United States)

    Dean, Richard A.

    1971-01-01

    The author shows that the set of all sequences in which each term is the sum of the two previous terms forms a vector space of dimension two. He uses this result to obtain the formula for the Fibonacci sequence and applies the same technique to other linear recursive relations. (MM)

  4. Support Vector Components Analysis

    NARCIS (Netherlands)

    van der Ree, Michiel; Roerdink, Johannes; Phillips, Christophe; Garraux, Gaetan; Salmon, Eric; Wiering, Marco

    2017-01-01

    In this paper we propose a novel method for learning a distance metric in the process of training Support Vector Machines (SVMs) with the radial basis function kernel. A transformation matrix is adapted in such a way that the SVM dual objective of a classification problem is optimized. By using a wi

  5. Synthetic Space Vector Modulation

    Science.gov (United States)

    2013-06-01

    Modulation RF Radio Frequency SVM Space Vector Modulation VCO Voltage Controlled Oscillator VSI Voltage Source Inverter xvi THIS PAGE...examining the literature, an NE566 voltage controlled oscillator ( VCO ) chip as seen in Figure 10 was used to design a circuit that produced the

  6. Production of lentiviral vectors

    Directory of Open Access Journals (Sweden)

    Otto-Wilhelm Merten

    2016-01-01

    Full Text Available Lentiviral vectors (LV have seen considerably increase in use as gene therapy vectors for the treatment of acquired and inherited diseases. This review presents the state of the art of the production of these vectors with particular emphasis on their large-scale production for clinical purposes. In contrast to oncoretroviral vectors, which are produced using stable producer cell lines, clinical-grade LV are in most of the cases produced by transient transfection of 293 or 293T cells grown in cell factories. However, more recent developments, also, tend to use hollow fiber reactor, suspension culture processes, and the implementation of stable producer cell lines. As is customary for the biotech industry, rather sophisticated downstream processing protocols have been established to remove any undesirable process-derived contaminant, such as plasmid or host cell DNA or host cell proteins. This review compares published large-scale production and purification processes of LV and presents their process performances. Furthermore, developments in the domain of stable cell lines and their way to the use of production vehicles of clinical material will be presented.

  7. Vector-borne Infections

    Centers for Disease Control (CDC) Podcasts

    2011-04-18

    This podcast discusses emerging vector-borne pathogens, their role as prominent contributors to emerging infectious diseases, how they're spread, and the ineffectiveness of mosquito control methods.  Created: 4/18/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 4/27/2011.

  8. What is a vector?

    Science.gov (United States)

    Wilson, Anthony James; Morgan, Eric René; Booth, Mark; Norman, Rachel; Perkins, Sarah Elizabeth; Hauffe, Heidi Christine; Mideo, Nicole; Antonovics, Janis; McCallum, Hamish; Fenton, Andy

    2017-05-05

    Many important and rapidly emerging pathogens of humans, livestock and wildlife are 'vector-borne'. However, the term 'vector' has been applied to diverse agents in a broad range of epidemiological systems. In this perspective, we briefly review some common definitions, identify the strengths and weaknesses of each and consider the functional differences between vectors and other hosts from a range of ecological, evolutionary and public health perspectives. We then consider how the use of designations can afford insights into our understanding of epidemiological and evolutionary processes that are not otherwise apparent. We conclude that from a medical and veterinary perspective, a combination of the 'haematophagous arthropod' and 'mobility' definitions is most useful because it offers important insights into contact structure and control and emphasizes the opportunities for pathogen shifts among taxonomically similar species with similar feeding modes and internal environments. From a population dynamics and evolutionary perspective, we suggest that a combination of the 'micropredator' and 'sequential' definition is most appropriate because it captures the key aspects of transmission biology and fitness consequences for the pathogen and vector itself. However, we explicitly recognize that the value of a definition always depends on the research question under study.This article is part of the themed issue 'Opening the black box: re-examining the ecology and evolution of parasite transmission'. © 2017 The Authors.

  9. Calculus with vectors

    CERN Document Server

    Treiman, Jay S

    2014-01-01

    Calculus with Vectors grew out of a strong need for a beginning calculus textbook for undergraduates who intend to pursue careers in STEM. fields. The approach introduces vector-valued functions from the start, emphasizing the connections between one-variable and multi-variable calculus. The text includes early vectors and early transcendentals and includes a rigorous but informal approach to vectors. Examples and focused applications are well presented along with an abundance of motivating exercises. All three-dimensional graphs have rotatable versions included as extra source materials and may be freely downloaded and manipulated with Maple Player; a free Maple Player App is available for the iPad on iTunes. The approaches taken to topics such as the derivation of the derivatives of sine and cosine, the approach to limits, and the use of "tables" of integration have been modified from the standards seen in other textbooks in order to maximize the ease with which students may comprehend the material. Additio...

  10. Estimation of vector velocity

    DEFF Research Database (Denmark)

    2000-01-01

    Using a pulsed ultrasound field, the two-dimensional velocity vector can be determined with the invention. The method uses a transversally modulated ultrasound field for probing the moving medium under investigation. A modified autocorrelation approach is used in the velocity estimation. The new...

  11. An Update on Canine Adenovirus Type 2 and Its Vectors

    Directory of Open Access Journals (Sweden)

    Eric J. Kremer

    2010-09-01

    Full Text Available Adenovirus vectors have significant potential for long- or short-term gene transfer. Preclinical and clinical studies using human derived adenoviruses (HAd have demonstrated the feasibility of flexible hybrid vector designs, robust expression and induction of protective immunity. However, clinical use of HAd vectors can, under some conditions, be limited by pre-existing vector immunity. Pre-existing humoral and cellular anti-capsid immunity limits the efficacy and duration of transgene expression and is poorly circumvented by injections of larger doses and immuno-suppressing drugs. This review updates canine adenovirus serotype 2 (CAV-2, also known as CAdV-2 biology and gives an overview of the generation of early region 1 (E1-deleted to helper-dependent (HD CAV-2 vectors. We also summarize the essential characteristics concerning their interaction with the anti-HAd memory immune responses in humans, the preferential transduction of neurons, and its high level of retrograde axonal transport in the central and peripheral nervous system. CAV-2 vectors are particularly interesting tools to study the pathophysiology and potential treatment of neurodegenerative diseases, as anti-tumoral and anti-viral vaccines, tracer of synaptic junctions, oncolytic virus and as a platform to generate chimeric vectors.

  12. Higher-order polarization singularitites in tailored vector beams

    Science.gov (United States)

    Otte, E.; Alpmann, C.; Denz, C.

    2016-07-01

    Higher-order polarization singularities embedded in tailored vector beams are introduced and experimentally realized. As holographic modulation allows to define order and location of any vectorial singularity, the surrounding vector field can be dynamically shaped. We demonstrate light fields associated with flowers or spider webs due to regular and even irregular patterns of the orientation of polarization ellipses. Beyond that, not yet investigated hybrid structures are introduced that allow generating networks of flowers and webs in very close vicinity. Our results pave the way to applications of singular optics in spatially extended, optimized optical tweezing and high-resolution imaging.

  13. VECTOR BUNDLE, KILLING VECTOR FIELD AND PONTRYAGIN NUMBERS

    Institute of Scientific and Technical Information of China (English)

    周建伟

    1991-01-01

    Let E be a vector bundle over a compact Riemannian manifold M. We construct a natural metric on the bundle space E and discuss the relationship between the killing vector fields of E and M. Then we give a proof of the Bott-Baum-Cheeger Theorem for vector bundle E.

  14. On Generalized Vector Equilibrium Problems

    Institute of Scientific and Technical Information of China (English)

    An-hua Wan; Jun-yi Fu; Wei-hua Mao

    2006-01-01

    A new generalized vector equilibrium problem involving set-valued mappings and the proper quasi-concavity of set-valued mappings in topological vector spaces are introduced; its existence theorems and the convexity of the solution sets are established.

  15. Vector mesons in matter

    Indian Academy of Sciences (India)

    Gy Wolf

    2006-04-01

    One consequence of the chiral restoration is the mixing of parity partners. We look for a possible signature of the mixing of vector and axial vector mesons in heavy-ion collisions. We suggest an experimental method for its observation. The dynamical evolution of the heavy-ion collision is described by a transport equation of QMD-type evolving nucleons, * and resonances, ’s and $\\sum$ baryons, and furthermore, ’s, ’s ’s ’s ’s and kaons with their isospin degrees of freedom. The input cross-sections and resonance parameters of the model are fitted to the available nucleon–nucleon and pion–nucleon cross-sections.

  16. Vector fields in cosmology

    CERN Document Server

    Davydov, Evgeny

    2011-01-01

    Vector fields can arise in the cosmological context in different ways, and we discuss both abelian and nonabelian sector. In the abelian sector vector fields of the geometrical origin (from dimensional reduction and Einstein-Eddington modification of gravity) can provide a very non-trivial dynamics, which can be expressed in terms of the effective dilaton-scalar gravity with the specific potential. In the non-abelian sector we investigate the Yang-Mills SU(2) theory which admits isotropic and homogeneous configuration. Provided the non-linear dependence of the lagrangian on the invariant F*F(dual), one can obtain the inflationary regime with the exponential growth of the scale factor. The effective amplitudes of the 'electric' and 'magnetic' components behave like slowly varying scalars at this regime, what allows the consideration of some realistic models with non-linear terms in the Yang-Mills lagrangian.

  17. Helices and vector bundles

    CERN Document Server

    Rudakov, A N

    1990-01-01

    This volume is devoted to the use of helices as a method for studying exceptional vector bundles, an important and natural concept in algebraic geometry. The work arises out of a series of seminars organised in Moscow by A. N. Rudakov. The first article sets up the general machinery, and later ones explore its use in various contexts. As to be expected, the approach is concrete; the theory is considered for quadrics, ruled surfaces, K3 surfaces and P3(C).

  18. Decay Constants of Vector Mesons

    Institute of Scientific and Technical Information of China (English)

    LI Heng-Mei; WAN Shao-Long

    2008-01-01

    @@ The light vector mesons are studied within the framework of the Bethe-Salpeter equation with the vector-vectortype flat-bottom potential The Bethe-Salpeter wavefunctions and the decay constants of the vector mesons are obtained. All the obtained results, fρ, fφ, and fΚ* , are in agreement with the experimental values, respectively.

  19. Student Preconceptions about Vector Kinematics.

    Science.gov (United States)

    Aguirre, Jose M.

    1988-01-01

    Examines preconceptions regarding several implicit vector characteristics that 15- to 17-year-old students possess just before taking their first physics course. Shows seven vector characteristics and three tasks for interviewing students. Presents the most common student preconceptions regarding each of the implicit vector characteristics. (YP)

  20. Interpolation of Vector Measures

    Institute of Scientific and Technical Information of China (English)

    Ricardo del CAMPO; Antonio FERN(A)NDEZ; Fernando MAYORAL; Francisco NARANJO; Enrique A. S(A)NCHEZ-P(E)REZ

    2011-01-01

    Let (Ω, ∑) be a measurable space and m0: ∑→ X0 and m1: ∑ -→ X1 be positive vector measures with values in the Banach K(o)the function spaces X0 and X1. If 0 < α < 1, we define a X10-αXα1 and we analyze the space of integrable functions with respect to measure [m0, m1]α in order to prove suitable extensions of the classical Stein-Weiss formulas that hold for the complex interpolation of Lp-spaces.Since each p-convex order continuous K(o)the function space with weak order unit can be represented as a space of p-integrable functions with respect to a vector measure, we provide in this way a technique to obtain representations of the corresponding complex interpolation spaces. As applications, we provide a Riesz-Thorin theorem for spaces of p-integrable functions with respect to vector measures and a formula for representing the interpolation of the injective tensor product of such spaces.

  1. Research on Modulation Strategies Based on Multilevel Inverter Universal Hybrid Topology

    Institute of Scientific and Technical Information of China (English)

    Zhou Jinghua; Su Yanmin; Shen Chuanwen; Zhang Lin

    2005-01-01

    Based on multi-module-cascaded inverter topology, this study presented a universal multilevel inverter hybrid topology and unified the researches on multilevel inverter topology. According to the freedom of this universal topology, several new hybrid topologies were constructed. Also, based on conventional modulation strategies- multi-carrier SPWM (Sinusoidal Pulse Width Modulation), hybrid modulation strategies were introduced corresponding to hybrid topologies, and a multilevel SVPWM (Space Vector Pulse Width Modulation) technique based on phase-shifted theory was naturally produced. Simulation and experiment results prove that hybrid topologies and corresponding modulation strategies are valid, which lay a foundation for practical application of hybrid multilevel inverter topologies.

  2. The Unified Floating Point Vector Coprocessor for Reconfigurable Hardware

    Science.gov (United States)

    Kathiara, Jainik

    There has been an increased interest recently in using embedded cores on FPGAs. Many of the applications that make use of these cores have floating point operations. Due to the complexity and expense of floating point hardware, these algorithms are usually converted to fixed point operations or implemented using floating-point emulation in software. As the technology advances, more and more homogeneous computational resources and fixed function embedded blocks are added to FPGAs and hence implementation of floating point hardware becomes a feasible option. In this research we have implemented a high performance, autonomous floating point vector Coprocessor (FPVC) that works independently within an embedded processor system. We have presented a unified approach to vector and scalar computation, using a single register file for both scalar operands and vector elements. The Hybrid vector/SIMD computational model of FPVC results in greater overall performance for most applications along with improved peak performance compared to other approaches. By parameterizing vector length and the number of vector lanes, we can design an application specific FPVC and take optimal advantage of the FPGA fabric. For this research we have also initiated designing a software library for various computational kernels, each of which adapts FPVC's configuration and provide maximal performance. The kernels implemented are from the area of linear algebra and include matrix multiplication and QR and Cholesky decomposition. We have demonstrated the operation of FPVC on a Xilinx Virtex 5 using the embedded PowerPC.

  3. Vector dissipativity theory for large-scale impulsive dynamical systems

    Directory of Open Access Journals (Sweden)

    Haddad Wassim M.

    2004-01-01

    Full Text Available Modern complex large-scale impulsive systems involve multiple modes of operation placing stringent demands on controller analysis of increasing complexity. In analyzing these large-scale systems, it is often desirable to treat the overall impulsive system as a collection of interconnected impulsive subsystems. Solution properties of the large-scale impulsive system are then deduced from the solution properties of the individual impulsive subsystems and the nature of the impulsive system interconnections. In this paper, we develop vector dissipativity theory for large-scale impulsive dynamical systems. Specifically, using vector storage functions and vector hybrid supply rates, dissipativity properties of the composite large-scale impulsive systems are shown to be determined from the dissipativity properties of the impulsive subsystems and their interconnections. Furthermore, extended Kalman-Yakubovich-Popov conditions, in terms of the impulsive subsystem dynamics and interconnection constraints, characterizing vector dissipativeness via vector system storage functions, are derived. Finally, these results are used to develop feedback interconnection stability results for large-scale impulsive dynamical systems using vector Lyapunov functions.

  4. Hybrid microelectronic technology

    Science.gov (United States)

    Moran, P.

    Various areas of hybrid microelectronic technology are discussed. The topics addressed include: basic thick film processing, thick film pastes and substrates, add-on components and attachment methods, thin film processing, and design of thick film hybrid circuits. Also considered are: packaging hybrid circuits, automating the production of hybrid circuits, application of hybrid techniques, customer's view of hybrid technology, and quality control and assurance in hybrid circuit production.

  5. A vector-form hybrid particle-element method for modeling and nonlinear shell analysis of thin membranes exhibiting wrinkling%基于向量式混合质点单元薄壳非线性分析方法的膜材褶皱形变模拟研究

    Institute of Scientific and Technical Information of China (English)

    Yao-zhi LUO; Chao YANG

    2014-01-01

    研究目的:建立一种适用于理想膜结构可进行高精度褶皱形变模拟的稳定可靠的数值分析技术及方法。  创新要点:根据薄壳理论,在向量式混合质点单元方法(VFPEM)薄膜计算理论的基础上,引入弯曲内力分析模型并与其进行组合,发展了一种能够描述膜材面外变形的新型非线性薄壳计算理论,同时给出了将其应用于褶皱形变模拟的关键求解技术。  研究方法:1.针对薄壳计算模型中的弯曲内力,利用移动基础架构和逆向刚体运动的概念扣除刚体转动,在只含有节点独立转动自由度的单元变形坐标系下根据虚功原理和平衡条件进行计算;2.借助于薄壳非线性屈曲模拟方法,引入合理的初始扰动作为诱发理想平面膜材中形成褶皱的有效机制;3.采用拟动力显式数值积分技术求解质点运动方程,通过追踪质点平衡位置来获得稳态的褶皱构形。  重要结论:采用本文模型和方法可以模拟薄膜结构在面内荷载作用下褶皱的分布模式、具体构形信息及应力状态,计算过程不存在收敛性困难,结果准确。%The wrinkling phenomenon is a commonly-known problem in many fields of engineering applications. Using a general structural analysis framework of the vector-form hybrid particle-element method (VHPEM), this paper presents a newly developed shell-based numerical model for the geometrically nonlinear wrinkling analysis of thin membranes. VHPEM is rooted in vector mechanics and physical perspective. It discretizes the analyzed domain into a group of finite particles linked by canonical elements, and the motions of the free particles are governed by Newton’s second law while the constrained ones follow the pre-scribed paths. An adaptive convected material frame is adopted for a general kinematical description. Internal forces related to the non-zero bending rigidity of a membrane can be

  6. Research on Hybrid-excited Flux-switching Machine and the Current Vector Control Strategy%并列式混合励磁磁通切换型电机及其电流矢量控制策略研究

    Institute of Scientific and Technical Information of China (English)

    朱婷婷; 邓智泉; 王宇

    2012-01-01

    As a solution to the magnetic field regulation problem in flux-switching permanent magnet motors, this paper presents a novel parallel hybrid excited flux-switching machine, which takes on high power density, intrinsic sinusoidal back EMF, and good field regulation ability. Based on field simulation, this paper made detailed analysis on the inductance characteristics and the field-weakening performance established the mathematical model and brought out a new current vector control strategy. The results show that the strategy achieved good static characteristics as well as maximum torque/copper loss ratio. A principle prototype was built to validate its excellent field regulation performance as well as the effectiveness of the presented control strategy.%为解决永磁磁通切换式电机磁场调节困难的问题,研究了一种新型并列式混合励磁磁通切换型(parallelhybridexcitedflux.switching,PHEFSl电机,该电机继承了永磁磁通切换电机功率密度高、反电势正弦等优势,且具有较强的对称调磁能力。结合磁路仿真对该电机电感特性和弱磁性能进行了理论分析,建立了PHEFS电机的数学模型,提出了id=0最大转矩铜耗比电流矢量控制策略,通过对励磁电流和电枢电流的合理分配,在保证静态特性的同时,达到最大转矩铜耗比,以提高电机的运行效率。原理样机的实验结果证明了该电机良好的调磁性能及所提算法的合理性与有效性。

  7. Números, vectores y funciones

    OpenAIRE

    1992-01-01

    El texto Números, Vectores y Funciones que han elaborado los profesores Asociados Omar Evelio Ospina y Bernardo Acevedo, responden a esta necesidad con sobresalientes cualidades pedagógicas, entre las cuales se destacan el desarrollo detallado de los temas y la proliferación de ejercicios resueltos, lo cual genera un diálogo directo con el lector que puede así aprovechar totalmente su lectura. El material presentado es el fruto de un cuidadoso análisis de los autores, sobre las experiencias d...

  8. Vector polarimetry at MAMI

    Energy Technology Data Exchange (ETDEWEB)

    Nillius, Fabian; Aulenbacher, Kurt [Institut fuer Kernphysik, Johannes Gutenberg-Universitaet Mainz (Germany)

    2013-07-01

    Electron/photon tensor-correlation coefficients may allow to design a polarimeter that can measure all components of beam polarisation simultaneously (''vector polarimeter''). Besides its purpose as a beam diagnostic device this would also allow to test theoretical predictions for the correlation coefficients at energies between 1 and 3.5 MeV. As a first step we have set up a measurement of the helicity transfer to the photon as a function of energy which is based on the Compton absorption method. Apparative developments in order to measure photon emission asymmetries caused by transverse and longitudinal electron polarisation are presented.

  9. Vector-borne diseases

    DEFF Research Database (Denmark)

    More, Simon J.; Bicout, Dominique; Bøtner, Anette

    2017-01-01

    After a request from the Europea n Commission, EFSA’s Panel on Animal Health and Welfaresummarised the main characteristics of 36 vector-borne disease s (VBDs) in 36 web-based storymaps.The risk of introduction in the EU through movement of livestock or pets was assessed for eac h of the36 VBDs...... new information becomesavailable. Since this risk assessment was carried out for large regions in the EU for many VBD-agents,it should be considered as a first screening. If a more detailed risk assessment for a specificVBDiswished for on a national or subnational level, the EFSA...

  10. Relativistic Rotating Vector Model

    CERN Document Server

    Lyutikov, Maxim

    2016-01-01

    The direction of polarization produced by a moving source rotates with the respect to the rest frame. We show that this effect, induced by pulsar rotation, leads to an important correction to polarization swings within the framework of rotating vector model (RVM); this effect has been missed by previous works. We construct relativistic RVM taking into account finite heights of the emission region that lead to aberration, time-of-travel effects and relativistic rotation of polarization. Polarizations swings at different frequencies can be used, within the assumption of the radius-to-frequency mapping, to infer emission radii and geometry of pulsars.

  11. Vector potential photoelectron microscopy.

    Science.gov (United States)

    Browning, R

    2011-10-01

    A new class of electron microscope has been developed for the chemical microanalysis of a wide range of real world samples using photoelectron spectroscopy. Highly structured, three-dimensional samples, such as fiber mats and fracture surfaces can be imaged, as well as insulators and magnetic materials. The new microscope uses the vector potential field from a solenoid magnet as a spatial reference for imaging. A prototype instrument has demonstrated imaging of uncoated silk, magnetic steel wool, and micron-sized single strand tungsten wires.

  12. Seafloor classification using echo- waveforms: A method employing hybrid neural network architecture

    Digital Repository Service at National Institute of Oceanography (India)

    Chakraborty, B.; Mahale, V.; DeSouza, C.; Das, P.

    This letter presents seafloor classification study results of a hybrid artificial neural network architecture known as learning vector quantization. Single beam echo-sounding backscatter waveform data from three different seafloors of the western...

  13. Hybrid Gear

    Science.gov (United States)

    Handschuh, Robert F. (Inventor); Roberts, Gary D. (Inventor)

    2016-01-01

    A hybrid gear consisting of metallic outer rim with gear teeth and metallic hub in combination with a composite lay up between the shaft interface (hub) and gear tooth rim is described. The composite lay-up lightens the gear member while having similar torque carrying capability and it attenuates the impact loading driven noise/vibration that is typical in gear systems. The gear has the same operational capability with respect to shaft speed, torque, and temperature as an all-metallic gear as used in aerospace gear design.

  14. Hybrid Qualifications

    DEFF Research Database (Denmark)

    has turned out as a major focus of European education and training policies and certainly is a crucial principle underlying the European Qualifications Framework (EQF). In this context, «hybrid qualifications» (HQ) may be seen as an interesting approach to tackle these challenges as they serve «two...... masters», i.e. by producing skills for the labour market and enabling individuals to progress more or less directly to higher education. The specific focus of this book is placed on conditions, structures and processes which help to combine VET with qualifications leading into higher education...

  15. Extended vector-tensor theories

    Science.gov (United States)

    Kimura, Rampei; Naruko, Atsushi; Yoshida, Daisuke

    2017-01-01

    Recently, several extensions of massive vector theory in curved space-time have been proposed in many literatures. In this paper, we consider the most general vector-tensor theories that contain up to two derivatives with respect to metric and vector field. By imposing a degeneracy condition of the Lagrangian in the context of ADM decomposition of space-time to eliminate an unwanted mode, we construct a new class of massive vector theories where five degrees of freedom can propagate, corresponding to three for massive vector modes and two for massless tensor modes. We find that the generalized Proca and the beyond generalized Proca theories up to the quartic Lagrangian, which should be included in this formulation, are degenerate theories even in curved space-time. Finally, introducing new metric and vector field transformations, we investigate the properties of thus obtained theories under such transformations.

  16. Semitopological Vector Spaces and Hyperseminorms

    Directory of Open Access Journals (Sweden)

    Mark Burgin

    2013-11-01

    Full Text Available In this paper, we introduce and study semitopological vector spaces. The goal is to provide an efficient base for developing the theory of extrafunction spaces in an abstract setting of algebraic systems and topological spaces. Semitopological vector spaces are more general than conventional topological vector spaces, which proved to be very useful for solving many problems in functional analysis. To study semitopological vector spaces, hypermetrics and hyperpseudometrics are introduced and it is demonstrated that hyperseminorms, studied in previous works of the author, induce hyperpseudometrics, while hypernorms induce hypermetrics. Sufficient and necessary conditions for a hyperpseudometric (hypermetric to be induced by a hyperseminorm (hypernorm are found. We also show that semitopological vector spaces are closely related to systems of hyperseminorms. Then defining boundedness and continuity relative to associated systems of hyperseminorms, we study relations between relative boundedness and relative continuity for mappings of vector spaces with systems of hyperseminorms and systems of hypernorms.

  17. Hybrid SVM/HMM Method for Face Recognition

    Institute of Scientific and Technical Information of China (English)

    刘江华; 陈佳品; 程君实

    2004-01-01

    A face recognition system based on Support Vector Machine (SVM) and Hidden Markov Model (HMM) has been proposed. The powerful discriminative ability of SVM is combined with the temporal modeling ability of HMM. The output of SVM is moderated to be probability output, which replaces the Mixture of Gauss (MOG) in HMM. Wavelet transformation is used to extract observation vector, which reduces the data dimension and improves the robustness.The hybrid system is compared with pure HMM face recognition method based on ORL face database and Yale face database. Experiments results show that the hybrid method has better performance.

  18. Safety considerations in vector development.

    Science.gov (United States)

    Kappes, J C; Wu, X

    2001-11-01

    The inadvertent production of replication competent retrovirus (RCR) constitutes the principal safety concern for the use of lentiviral vectors in human clinical protocols. Because of limitations in animal models to evaluate lentiviral vectors for their potential to recombine and induce disease, the vector design itself should ensure against the emergence of RCR in vivo. Issues related to RCR generation and one approach to dealing with this problem are discussed in this chapter. To assess the risk of generating RCR, a highly sensitive biological assay was developed to specifically detect vector recombination in transduced cells. Analysis of lentiviral vector stocks has shown that recombination occurs during reverse transcription in primary target cells. Rejoining of viral protein-coding sequences of the packaging construct and cis-acting sequences of the vector was demonstrated to generate env-minus recombinants (LTR-gag-pol-LTR). Mobilization of recombinant lentiviral genomes was also demonstrated but was dependent on pseudotyping of the vector core with an exogenous envelope protein. 5' sequence analysis has demonstrated that recombinants consist of U3, R, U5, and the psi packaging signal joined with an open gag coding region. Analysis of the 3' end has mapped the point of vector recombination to the poly(A) tract of the packaging construct's mRNA. The state-of-the-art third generation packaging construct and SIN vector also have been shown to generate env-minus proviral recombinants capable of mobilizing retroviral DNA when pseudotyped with an exogenous envelope protein. A new class of HIV-based vector (trans-vector) was recently developed that splits the gag-pol component of the packaging construct into two parts: one that expresses Gag/Gag-Pro and another that expresses Pol (RT and IN) fused with Vpr. Unlike other lentiviral vectors, the trans-vector has not been shown to form recombinants capable of DNA mobilization. These results indicate the trans-vector

  19. VLSI Processor For Vector Quantization

    Science.gov (United States)

    Tawel, Raoul

    1995-01-01

    Pixel intensities in each kernel compared simultaneously with all code vectors. Prototype high-performance, low-power, very-large-scale integrated (VLSI) circuit designed to perform compression of image data by vector-quantization method. Contains relatively simple analog computational cells operating on direct or buffered outputs of photodetectors grouped into blocks in imaging array, yielding vector-quantization code word for each such block in sequence. Scheme exploits parallel-processing nature of vector-quantization architecture, with consequent increase in speed.

  20. Vectors in a Box

    CERN Document Server

    Buchin, Kevin; Moser, Robin A; Pálvölgyi, Dömötör

    2009-01-01

    For an integer d>=1, let tau(d) be the smallest integer with the following property: If v1,v2,...,vt is a sequence of t>=2 vectors in [-1,1]^d with v1+v2+...+vt in [-1,1]^d, then there is a subset S of {1,2,...,t} of indices, 2= d^{d/2-o(d)}. These results contribute to understanding the master equality polyhedron with multiple rows defined by Dash et al., which is a "universal" polyhedron encoding valid cutting planes for integer programs (this line of research was started by Gomory in the late 1960s). In particular, the upper bound on tau(d) implies a pseudo-polynomial running time for an algorithm of Dash et al. for integer programming with a fixed number of constraints. The algorithm consists in solving a linear program, and it provides an alternative to a 1981 dynamic programming algorithm of Papadimitriou.

  1. Entangled vector vortex beams

    Science.gov (United States)

    D'Ambrosio, Vincenzo; Carvacho, Gonzalo; Graffitti, Francesco; Vitelli, Chiara; Piccirillo, Bruno; Marrucci, Lorenzo; Sciarrino, Fabio

    2016-09-01

    Light beams having a vectorial field structure, or polarization, that varies over the transverse profile and a central optical singularity are called vector vortex (VV) beams and may exhibit specific properties such as focusing into "light needles" or rotation invariance. VV beams have already found applications in areas ranging from microscopy to metrology, optical trapping, nano-optics, and quantum communication. Individual photons in such beams exhibit a form of single-particle quantum entanglement between different degrees of freedom. On the other hand, the quantum states of two photons can be also entangled with each other. Here, we combine these two concepts and demonstrate the generation of quantum entanglement between two photons that are both in VV states: a form of entanglement between two complex vectorial fields. This result may lead to quantum-enhanced applications of VV beams as well as to quantum information protocols fully exploiting the vectorial features of light.

  2. Solar imaging vector magnetograph

    Science.gov (United States)

    Canfield, Richard C.

    1993-01-01

    This report describes an instrument which has been constructed at the University of Hawaii to make observations of the magnetic field in solar active regions. Detailed knowledge of active region magnetic structures is crucial to understanding many solar phenomena, because the magnetic field both defines the morphology of structures seen in the solar atmosphere and is the apparent energy source for solar flares. The new vector magnetograph was conceived in response to a perceived discrepancy between the capabilities of X ray imaging telescopes to be operating during the current solar maximum and those of existing magnetographs. There were no space-based magnetographs planned for this period; the existing ground-based instruments variously suffered from lack of sensitivity, poor time resolution, inadequate spatial resolution or unreliable sites. Yet the studies of flares and their relationship to the solar corona planned for the 1991-1994 maximum absolutely required high quality vector magnetic field measurements. By 'vector' measurements we mean that the observation attempts to deduce the complete strength and direction of the field at the measurement site, rather than just the line of sight component as obtained by a traditional longitudinal magnetograph. Knowledge of the vector field permits one to calculate photospheric electric currents, which might play a part in heating the corona, and to calculate energy stored in coronal magnetic fields as the result of such currents. Information about the strength and direction of magnetic fields in the solar atmosphere can be obtained in a number of ways, but quantitative data is best obtained by observing Zeeman-effect polarization in solar spectral lines. The technique requires measuring the complete state of polarization at one or more wavelengths within a magnetically sensitive line of the solar spectrum. This measurement must be done for each independent spatial point for which one wants magnetic field data. All the

  3. Resonance vector mode locking

    CERN Document Server

    Kolpakov, Stanislav A; Loika, Yuri; Tarasov, Nikita; Kalashnikov, Vladimir; Agrawal, Govind P

    2015-01-01

    A mode locked fibre laser as a source of ultra-stable pulse train has revolutionised a wide range of fundamental and applied research areas by offering high peak powers, high repetition rates, femtosecond range pulse widths and a narrow linewidth. However, further progress in linewidth narrowing seems to be limited by the complexity of the carrier-envelope phase control. Here for the first time we demonstrate experimentally and theoretically a new mechanism of resonance vector self-mode locking where tuning in-cavity birefringence leads to excitation of the longitudinal modes sidebands accompanied by the resonance phase locking of sidebands with the adjacent longitudinal modes. An additional resonance with acoustic phonons provides the repetition rate tunability and linewidth narrowing down to Hz range that drastically reduces the complexity of the carrier-envelope phase control and so will open the way to advance lasers in the context of applications in metrology, spectroscopy, microwave photonics, astronomy...

  4. Intuitionistic hybrid logic

    DEFF Research Database (Denmark)

    Braüner, Torben

    2011-01-01

    Intuitionistic hybrid logic is hybrid modal logic over an intuitionistic logic basis instead of a classical logical basis. In this short paper we introduce intuitionistic hybrid logic and we give a survey of work in the area.......Intuitionistic hybrid logic is hybrid modal logic over an intuitionistic logic basis instead of a classical logical basis. In this short paper we introduce intuitionistic hybrid logic and we give a survey of work in the area....

  5. Continuity Controlled Hybrid Automata

    OpenAIRE

    Bergstra, J. A.; Middelburg, C.A.

    2004-01-01

    We investigate the connections between the process algebra for hybrid systems of Bergstra and Middelburg and the formalism of hybrid automata of Henzinger et al. We give interpretations of hybrid automata in the process algebra for hybrid systems and compare them with the standard interpretation of hybrid automata as timed transition systems. We also relate the synchronized product operator on hybrid automata to the parallel composition operator of the process algebra. It turns out that the f...

  6. Vector-Tensor and Vector-Vector Decay Amplitude Analysis of B0->phi K*0

    CERN Document Server

    Aubert, B; Abrams, G S; Adye, T; Ahmed, S; Alam, M S; Albert, J; Aleksan, R; Allen, M T; Allison, J; Altenburg, D D; Andreotti, M; Angelini, C; Anulli, F; Arnaud, N; Asgeirsson, D J; Aston, D; Azzolini, V; Baak, M A; Back, J J; Baldini-Ferroli, R; Band, H R; Banerjee, Sw; Bard, D J; Barlow, N R; Barlow, R J; Barrett, M; Bartoldus, R; Batignani, G; Battaglia, M; Bauer, J M; Bechtle, P; Beck, T W; Behera, P K; Bellini, F; Benayoun, M; Benelli, G; Berger, N; Bernard, D; Berryhill, J W; Best, D S; Bettarini, S; Bettoni, D; Bevan, A J; Bhimji, W; Bhuyan, B; Bianchi, F; Biasini, M; Biesiada, J; Blanc, F; Blaylock, G; Blinov, V E; Bloom, P C; Blount, N L; Bomben, M; Bondioli, M; Bonneaud, G R; Bosisio, L; Boutigny, D; Bowerman, D A; Boyd, J T; Bozzi, C; Brandenburg, G; Brandt, T; Brau, J E; Briand, H; Brown, C M; Brown, D N; Bruinsma, M; Brunet, S; Bucci, F; Buchanan, C; Bugg, W; Bukin, A D; Bula, R; Burchat, P R; Burke, J P; Button-Shafer, J; Buzzo, A; Bóna, M; Cahn, R N; Calabrese, R; Calcaterra, A; Calderini, G; Campagnari, C; Carpinelli, M; Cartaro, C; Cavallo, N; Cavoto, G; Cenci, R; Chai, X; Chaisanguanthum, K S; Chao, M; Charles, E; Charles, M J; Chauveau, J; Chavez, C A; Chen, A; Chen, C; Chen, E; Chen, J C; Chen, S; Chen, X; Chen, X R; Cheng, B; Cheng, C H; Chia, Y M; Cibinetto, G; Clark, P J; Clarke, C K; Claus, R; Cochran, J; Coleman, J P; Contri, R; Convery, M R; Corwin, L A; Cossutti, F; Cottingham, W N; Couderc, F; Covarelli, R; Cowan, G; Cowan, R; Crawley, H B; Cremaldi, L; Cunha, A; Curry, S; Côté, D; D'Orazio, A; Dahmes, B; Dallapiccola, C; Danielson, N; Dasu, S; Datta, M; Dauncey, P D; David, P; Davier, M; Davis, C L; De Nardo, Gallieno; De Sangro, R; Del Amo-Sánchez, P; Del Buono, L; Del Re, D; Della Ricca, G; Denig, A G; Di Lodovico, F; Di Marco, E; Dingfelder, J C; Dittongo, S; Dong, L; Dorfan, J; Druzhinin, V P; Dubitzky, R S; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Dvoretskii, A; Ebert, M; Eckhart, E A; Eckmann, R; Edgar, C L; Edwards, A J; Egede, U; Eigen, G; Eisner, A M; Elmer, P; Emery, S; Ernst, J A; Eschenburg, V; Eschrich, I; Eyges, V; Fabozzi, F; Faccini, R; Fang, F; Feltresi, E; Ferrarotto, F; Ferroni, F; Field, R C; Finocchiaro, G; Flacco, C J; Flack, R L; Flächer, H U; Flood, K T; Ford, K E; Ford, W T; Forster, I J; Forti, F; Fortin, D; Foulkes, S D; Franek, B; Frey, R; Fritsch, M; Fry, J R; Fulsom, B G; Gabathuler, E; Gaidot, A; Gallo, F; Gamba, D; Gamet, R; Gan, K K; Ganzhur, S F; Gao, Y; Gary, J W; Gaspero, M; Gatto, C; Gaz, A; George, K A; Gill, M S; Giorgi, M A; Gladney, L; Glanzman, T; Godang, R; Golubev, V B; Gowdy, S J; Gradl, W; Graham, M T; Graugès-Pous, E; Grenier, P; Gritsan, A V; Grosdidier, G; Groysman, Y; Guo, Z J; Hadavand, H K; Haire, M; Halyo, V; Hamano, K; Hamel de Monchenault, G; Hamon, O; Harrison, P F; Harrison, T J; Hart, A J; Hartfiel, B L; Hast, C; Hauke, A; Hawkes, C M; Hearty, C; Held, T; Hertzbach, S S; Heusch, C A; Hill, E J; Hirschauer, J F; Hitlin, D G; Hollar, J J; Hong, T M; Honscheid, K; Hopkins, D A; Hrynóva, T; Hufnagel, D; Hulsbergen, W D; Hutchcroft, D E; Höcker, A; Igonkina, O; Innes, W R; Izen, J M; Jackson, P D; Jackson, P S; Jacobsen, R G; Jain, V; Jasper, H; Jawahery, A; Jessop, C P; Judd, D; Kadyk, J A; Kagan, H; Karyotakis, Yu; Kass, R; Kelsey, M H; Kerth, L T; Khan, A; Kim, H; Kim, P; Kirkby, D; Klose, V; Knecht, N S; Koch, H; Kolb, J A; Kolomensky, Yu G; Kovalskyi, D; Kowalewski, R V; Kozanecki, Witold; Kreisel, A; Krishnamurthy, M; Kroeger, R; Kroseberg, J; Kukartsev, G; Kutter, P E; Kyberd, P; La Vaissière, C de; Lacker, H M; Lae, C K; Lafferty, G D; Lanceri, L; Lange, D J; Lankford, A J; Latham, T E; Latour, E; Lau, Y P; Lazzaro, A; Le Diberder, F R; Lee, C L; Lees, J P; Legendre, M; Leith, D W G S; Lepeltier, V; Leruste, P; Lewandowski, B; Li Gioi, L; Li, S; Li, X; Lista, L; Liu, H; Lo Vetere, M; LoSecco, J M; Lockman, W S; Lombardo, V; Long, O; Lopes-Pegna, D; Lopez-March, N; Lou, X C; Lu, M; Luitz, S; Lund, P; Luppi, E; Lusiani, A; Lutz, A M; Lynch, G; Lynch, H L; Lü, C; Lüth, V; MacFarlane, D B; Macri, M M; Mader, W F; Majewski, S A; Malcles, J; Mallik, U; Mancinelli, G; Mandelkern, M A; Marchiori, G; Margoni, M; Marks, J; Marsiske, H; Martínez-Vidal, F; Mattison, T S; Mazur, M A; Mazzoni, M A; McKenna, J A; McMahon, T R; Mclachlin, S E; Meadows, B T; Mellado, B; Menges, W; Merkel, J; Messner, R; Meyer, N T; Meyer, W T; Mihályi, A; Mir, L M; Mishra, K; Mohanty, G B; Monge, M R; Monorchio, D; Moore, T B; Morandin, M; Morganti, M; Morganti, S; Morii, M; Muheim, F; Müller, D R; Nagel, M; Naisbit, M T; Narsky, I; Nash, J A; Nauenberg, U; Neal, H; Negrini, M; Neri, N; Nesom, G; Nicholson, H; Nikolich, M B; Nogowski, R; Nugent, I M; O'Grady, C P; Ocariz, J; Ofte, I; Olaiya, E O; Olivas, A; Olsen, J; Onuchin, A P; Orimoto, T J; Oyanguren, A; Ozcan, V E; Paar, H P; Pacetti, S; Palano, A; Palombo, F; Pan, B; Pan, Y; Panduro, W; Paoloni, E; Paolucci, P; Pappagallo, M; Park, W; Passaggio, S; Patel, P M; Patrignani, C; Patteri, P; Payne, D J; Pelizaeus, M; Perazzo, A; Perl, M; Peruzzi, I M; Peters, K; Petersen, B A; Petrella, A; Petzold, A; Piatenko, T; Piccolo, D; Piccolo, M; Piemontese, L; Pierini, M; Piredda, G; Playfer, S; Poireau, V; Polci, F; Pompili, A; Porter, F C; Posocco, M; Potter, C T; Prell, S; Prencipe, E; Prepost, R; Pripstein, M; Pruvot, S; Pulliam, T; Purohit, M V; Qi, N D; Rahatlou, S; Rahimi, A M; Rahmat, R; Rama, M; Ratcliff, B N; Raven, G; Regensburger, J J; Ricciardi, S; Richman, J D; Ritchie, J L; Rizzo, G; Roberts, D A; Robertson, A I; Robertson, S H; Robutti, E; Rodier, S; Roe, N A; Ronan, M T; Roney, J M; Rong, G; Roodman, A; Roos, L; Rosenberg, E I; Rotondo, M; Roudeau, P; Rubin, A E; Ruddick, W O; Röthel, W; Sacco, R; Saeed, M A; Safai-Tehrani, F; Saleem, M; Salnikov, A A; Salvatore, F; Sanders, D A; Santroni, A; Saremi, S; Satpathy, A; Schalk, T; Schenk, S; Schilling, C J; Schindler, R H; Schofield, K C; Schott, G; Schröder, T; Schröder, H; Schubert, J; Schubert, K R; Schumm, B A; Schune, M H; Schwiening, J; Schwierz, R; Schwitters, R F; Sciacca, C; Sciolla, G; Seiden, A; Sekula, S J; Serednyakov, S I; Serrano, J; Sharma, V; Shen, B C; Sherwood, D J; Simard, M; Simi, G; Simonetto, F; Sinev, N B; Skovpen, Yu I; Smith, A J S; Smith, J G; Snoek, H L; Snyder, A; Sobie, R J; Soffer, A; Sokoloff, M D; Solodov, E P; Spaan, B; Spanier, S M; Spitznagel, M; Spradlin, P; Steinke, M; Stelzer, J; Stocchi, A; Stoker, D P; Stroili, R; Strom, D; Strube, J; Stugu, B; Stängle, H; Su, D; Sullivan, M K; Summers, D J; Sundermann, J E; Suzuki, K; Swain, S K; Taras, P; Taylor, F; Telnov, A V; Teodorescu, L; Ter-Antonian, R; Therin, G; Thiebaux, C; Thompson, J M; Tisserand, V; Todyshev, Y K; Toki, W H; Torrence, E; Tosi, S; Touramanis, C; Ulmer, K A; Uwer, U; Van Bakel, N; Vasseur, G; Vavra, J; Vazquez, A; Verderi, M; Viaud, F B; Vitale, L; Voci, C; Voena, C; Volk, A; Wagner, A P; Wagner, S R; Wagoner, D E; Waldi, R; Walker, D; Walsh, J J; Wang, K; Wang, P; Wang, W F; Wappler, F R; Watson, A T; Weaver, M; Weinstein, A J R; Wenzel, W A; Wilden, L; Williams, D C; Williams, J C; Wilson, F F; Wilson, J R; Wilson, M G; Wilson, R J; Winklmeier, F; Wisniewski, W J; Wittgen, M; Wong, Q K; Wormser, G; Wren, A C; Wright, D H; Wright, D M; Wu, J; Wu, S L; Wulsin, H W; Xie, Y; Yamamoto, R K; Yarritu, A K; Ye, S; Yi, J I; Yi, K; Young, C C; Yu, Z; Yéche, C; Zain, S B; Zallo, A; Zeng, Q; Zghiche, A; Zhang, J; Zhang, L; Zhao, H W; Zhu, Y S; Ziegler, V; Zito, M; Çuhadar-Dönszelmann, T; al, et

    2007-01-01

    We perform an amplitude analysis of the decays B0->phi K^*_2(1430)0, phi K^*(892)0, and phi(K pi)^0_S-wave with a sample of about 384 million BBbar pairs recorded with the BABAR detector. The fractions of longitudinal polarization f_L of the vector-tensor and vector-vector decay modes are measured to be 0.853 +0.061-0.069 +-0.036 and 0.506 +-0.040 +-0.015, respectively. Overall, twelve parameters are measured for the vector-vector decay and seven parameters for the vector-tensor decay, including the branching fractions and parameters sensitive to CP-violation.

  7. Execution of vector operations for Intel 860

    Energy Technology Data Exchange (ETDEWEB)

    Khaletskii, D.A.

    1995-03-01

    When designing a portable setup compiler from the C[] language, the compiler setup problem is solved for various SIMD computers. A vector and vector operations are defined in C[]. A map of vector operations is trivial for computers with vector registers. Some problems appear when mapping them to computers without vector registers. It is shown how to effectively perform vector operations for the 1860 microcomputer as an example of one without vector registers.

  8. Hybridized tetraquarks

    Directory of Open Access Journals (Sweden)

    A. Esposito

    2016-07-01

    Full Text Available We propose a new interpretation of the neutral and charged X,Z exotic hadron resonances. Hybridized-tetraquarks are neither purely compact tetraquark states nor bound or loosely bound molecules but rather a manifestation of the interplay between the two. While meson molecules need a negative or zero binding energy, its counterpart for h-tetraquarks is required to be positive. The formation mechanism of this new class of hadrons is inspired by that of Feshbach metastable states in atomic physics. The recent claim of an exotic resonance in the Bs0π± channel by the D0 Collaboration and the negative result presented subsequently by the LHCb Collaboration are understood in this scheme, together with a considerable portion of available data on X,Z particles. Considerations on a state with the same quantum numbers as the X(5568 are also made.

  9. Hybridized Tetraquarks

    CERN Document Server

    Esposito, A.; Polosa, A.D.

    2016-01-01

    We propose a new interpretation of the neutral and charged X, Z exotic hadron resonances. Hybridized-tetraquarks are neither purely compact tetraquark states nor bound or loosely bound molecules. The latter would require a negative or zero binding energy whose counterpart in h-tetraquarks is a positive quantity. The formation mechanism of this new class of hadrons is inspired by that of Feshbach metastable states in atomic physics. The recent claim of an exotic resonance in the Bs pi+- channel by the D0 collaboration and the negative result presented subsequently by the LHCb collaboration are understood in this scheme, together with a considerable portion of available data on X, Z particles. Considerations on a state with the same quantum numbers as the X(5568) are also made.

  10. Vectors on the Basketball Court

    Science.gov (United States)

    Bergman, Daniel

    2010-01-01

    An Idea Bank published in the April/May 2009 issue of "The Science Teacher" describes an experiential physics lesson on vectors and vector addition (Brown 2009). Like its football predecessor, the basketball-based investigation presented in this Idea Bank addresses National Science Education Standards Content B, Physical Science, 9-12 (NRC 1996)…

  11. Simplified Representation of Vector Fields

    NARCIS (Netherlands)

    Telea, Alexandru; Wijk, Jarke J. van

    1999-01-01

    Vector field visualization remains a difficult task. Although many local and global visualization methods for vector fields such as flow data exist, they usually require extensive user experience on setting the visualization parameters in order to produce images communicating the desired insight. We

  12. Testing identifiablility of cointegrating vectors

    NARCIS (Netherlands)

    H.P. Boswijk

    1996-01-01

    This article analyzes the identification and normalization of cointegrating vectors. Normalizing a cointegrating relation with respect to one of the relevant variables is with loss of generality; and restrictions that are supposed to identify a vector may fail to do so for particular parameter value

  13. Estimation of Motion Vector Fields

    DEFF Research Database (Denmark)

    Larsen, Rasmus

    1993-01-01

    This paper presents an approach to the estimation of 2-D motion vector fields from time varying image sequences. We use a piecewise smooth model based on coupled vector/binary Markov random fields. We find the maximum a posteriori solution by simulated annealing. The algorithm generate sample...

  14. Simplified Representation of Vector Fields

    NARCIS (Netherlands)

    Telea, Alexandru; Wijk, Jarke J. van

    1999-01-01

    Vector field visualization remains a difficult task. Although many local and global visualization methods for vector fields such as flow data exist, they usually require extensive user experience on setting the visualization parameters in order to produce images communicating the desired insight. We

  15. GPU Accelerated Vector Median Filter

    Science.gov (United States)

    Aras, Rifat; Shen, Yuzhong

    2011-01-01

    Noise reduction is an important step for most image processing tasks. For three channel color images, a widely used technique is vector median filter in which color values of pixels are treated as 3-component vectors. Vector median filters are computationally expensive; for a window size of n x n, each of the n(sup 2) vectors has to be compared with other n(sup 2) - 1 vectors in distances. General purpose computation on graphics processing units (GPUs) is the paradigm of utilizing high-performance many-core GPU architectures for computation tasks that are normally handled by CPUs. In this work. NVIDIA's Compute Unified Device Architecture (CUDA) paradigm is used to accelerate vector median filtering. which has to the best of our knowledge never been done before. The performance of GPU accelerated vector median filter is compared to that of the CPU and MPI-based versions for different image and window sizes, Initial findings of the study showed 100x improvement of performance of vector median filter implementation on GPUs over CPU implementations and further speed-up is expected after more extensive optimizations of the GPU algorithm .

  16. 3-D Vector Flow Imaging

    DEFF Research Database (Denmark)

    Holbek, Simon

    For the last decade, the field of ultrasonic vector flow imaging has gotten an increasingly attention, as the technique offers a variety of new applications for screening and diagnostics of cardiovascular pathologies. The main purpose of this PhD project was therefore to advance the field of 3-D...... ultrasonic vector flow estimation and bring it a step closer to a clinical application. A method for high frame rate 3-D vector flow estimation in a plane using the transverse oscillation method combined with a 1024 channel 2-D matrix array is presented. The proposed method is validated both through phantom......, if this significant reduction in the element count can still provide precise and robust 3-D vector flow estimates in a plane. The study concludes that the RC array is capable of estimating precise 3-D vector flow both in a plane and in a volume, despite the low channel count. However, some inherent new challenges...

  17. Various challenging aspects of hybrid propulsion

    Science.gov (United States)

    Orlandi, O.; Theil, D.; Saramago, J.; Amand, P. G.; Dauch, F.; Gautier, P.

    2011-10-01

    The hybrid technology appears as an innovative, high performance, and promising propulsion technique in a number of space missions. By combining functions and advantages taken from both solid and liquid propulsion, this technology is expected to provide mainly high performance with throttleability and stop-restart capabilities. The safety conditions of engine operation and design reliability almost similar to solid propulsion increase the interest to this technology. However, the standard fuels (mainly based on a carbon polymer) exhibit low regression rates that require complex grain shapes and low loading ratio. Thanks to a dedicated study supported by the European Space Agency (ESA), SNPE in collaboration with Avio and University of Naples (DIAS department) performed an exhaustive state-of-the-art and a market survey of accomplishments in hybrid propulsion. Based on the resulting tradeoff study on potential future launchers and spacecraft applications, the most promising applications are selected to conduct preliminary designs. These applications can also be seen as the vector of hybrid propulsion development. This study concentrates on hybrid propulsion systems with advanced hybrid fuels for Lander platform and Upper Stage. High throttleability and high propulsive performance associated with stop and restart capability are needed to meet mission requirements for Lander and Upper Stage, respectively. Preliminary design shows the advantages provided by hybrid propulsion: a significant payload mass increase for the upper stage case and a soft landing for the Lander case.

  18. Emerging vector borne diseases – incidence through vectors

    Directory of Open Access Journals (Sweden)

    Sara eSavic

    2014-12-01

    Full Text Available Vector borne diseases use to be a major public health concern only in tropical and subtropical areas, but today they are an emerging threat for the continental and developed countries also. Nowdays, in intercontinetal countries, there is a struggle with emerging diseases which have found their way to appear through vectors. Vector borne zoonotic diseases occur when vectors, animal hosts, climate conditions, pathogens and susceptible human population exist at the same time, at the same place. Global climate change is predicted to lead to an increase in vector borne infectious diseases and disease outbreaks. It could affect the range and popultion of pathogens, host and vectors, transmission season, etc. Reliable surveilance for diseases that are most likely to emerge is required. Canine vector borne diseases represent a complex group of diseases including anaplasmosis, babesiosis, bartonellosis, borreliosis, dirofilariosis, erlichiosis, leishmaniosis. Some of these diseases cause serious clinical symptoms in dogs and some of them have a zoonotic potential with an effect to public health. It is expected from veterinarians in coordination with medical doctors to play a fudamental role at primeraly prevention and then treatment of vector borne diseases in dogs. The One Health concept has to be integrated into the struggle against emerging diseases.During a four year period, from 2009-2013, a total number of 551 dog samples were analysed for vector borne diseases (borreliosis, babesiosis, erlichiosis, anaplasmosis, dirofilariosis and leishmaniasis in routine laboratory work. The analysis were done by serological tests – ELISA for borreliosis, dirofilariosis and leishmaniasis, modified Knott test for dirofilariosis and blood smear for babesiosis, erlichiosis and anaplasmosis. This number of samples represented 75% of total number of samples that were sent for analysis for different diseases in dogs. Annually, on avarege more then half of the samples

  19. Hybrid proteins between Pseudomonas exotoxin A and poliovirus protease 2Apro.

    Science.gov (United States)

    Novoa, I; Feduchi, E; Carrasco, L

    1994-11-21

    Two hybrid proteins between Pseudomonas aeruginosa exotoxin A (PE) and poliovirus protease 2Apro have been generated. One hybrid protein contains the poliovirus 2Apro sequence replacing the region of PE corresponding to amino acids 413-607. The other hybrid contains in addition the transforming growth factor sequence. The two hybrid proteins were efficiently synthesized in E. coli cells using the inducible pET vectors. Both hybrid toxins cleaved p220 (eIF-4 gamma) when the recombinant plasmids were transfected in COS cells infected with recombinant vaccinia virus bearing the T7 RNA polymerase gene.

  20. Continuity Controlled Hybrid Automata

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2004-01-01

    We investigate the connections between the process algebra for hybrid systems of Bergstra and Middelburg and the formalism of hybrid automata of Henzinger et al. We give interpretations of hybrid automata in the process algebra for hybrid systems and compare them with the standard interpretation of

  1. Continuity controlled Hybrid Automata

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2008-01-01

    We investigate the connections between the process algebra for hybrid systems of Bergstra and Middelburg and the formalism of hybrid automata of Henzinger et al. We give interpretations of hybrid automata in the process algebra for hybrid systems and compare them with the standard interpretation of

  2. HybridGO-Loc: mining hybrid features on gene ontology for predicting subcellular localization of multi-location proteins.

    Directory of Open Access Journals (Sweden)

    Shibiao Wan

    Full Text Available Protein subcellular localization prediction, as an essential step to elucidate the functions in vivo of proteins and identify drugs targets, has been extensively studied in previous decades. Instead of only determining subcellular localization of single-label proteins, recent studies have focused on predicting both single- and multi-location proteins. Computational methods based on Gene Ontology (GO have been demonstrated to be superior to methods based on other features. However, existing GO-based methods focus on the occurrences of GO terms and disregard their relationships. This paper proposes a multi-label subcellular-localization predictor, namely HybridGO-Loc, that leverages not only the GO term occurrences but also the inter-term relationships. This is achieved by hybridizing the GO frequencies of occurrences and the semantic similarity between GO terms. Given a protein, a set of GO terms are retrieved by searching against the gene ontology database, using the accession numbers of homologous proteins obtained via BLAST search as the keys. The frequency of GO occurrences and semantic similarity (SS between GO terms are used to formulate frequency vectors and semantic similarity vectors, respectively, which are subsequently hybridized to construct fusion vectors. An adaptive-decision based multi-label support vector machine (SVM classifier is proposed to classify the fusion vectors. Experimental results based on recent benchmark datasets and a new dataset containing novel proteins show that the proposed hybrid-feature predictor significantly outperforms predictors based on individual GO features as well as other state-of-the-art predictors. For readers' convenience, the HybridGO-Loc server, which is for predicting virus or plant proteins, is available online at http://bioinfo.eie.polyu.edu.hk/HybridGoServer/.

  3. HybridGO-Loc: Mining Hybrid Features on Gene Ontology for Predicting Subcellular Localization of Multi-Location Proteins

    Science.gov (United States)

    Wan, Shibiao; Mak, Man-Wai; Kung, Sun-Yuan

    2014-01-01

    Protein subcellular localization prediction, as an essential step to elucidate the functions in vivo of proteins and identify drugs targets, has been extensively studied in previous decades. Instead of only determining subcellular localization of single-label proteins, recent studies have focused on predicting both single- and multi-location proteins. Computational methods based on Gene Ontology (GO) have been demonstrated to be superior to methods based on other features. However, existing GO-based methods focus on the occurrences of GO terms and disregard their relationships. This paper proposes a multi-label subcellular-localization predictor, namely HybridGO-Loc, that leverages not only the GO term occurrences but also the inter-term relationships. This is achieved by hybridizing the GO frequencies of occurrences and the semantic similarity between GO terms. Given a protein, a set of GO terms are retrieved by searching against the gene ontology database, using the accession numbers of homologous proteins obtained via BLAST search as the keys. The frequency of GO occurrences and semantic similarity (SS) between GO terms are used to formulate frequency vectors and semantic similarity vectors, respectively, which are subsequently hybridized to construct fusion vectors. An adaptive-decision based multi-label support vector machine (SVM) classifier is proposed to classify the fusion vectors. Experimental results based on recent benchmark datasets and a new dataset containing novel proteins show that the proposed hybrid-feature predictor significantly outperforms predictors based on individual GO features as well as other state-of-the-art predictors. For readers' convenience, the HybridGO-Loc server, which is for predicting virus or plant proteins, is available online at http://bioinfo.eie.polyu.edu.hk/HybridGoServer/. PMID:24647341

  4. Chikungunya Virus–Vector Interactions

    Directory of Open Access Journals (Sweden)

    Lark L. Coffey

    2014-11-01

    Full Text Available Chikungunya virus (CHIKV is a mosquito-borne alphavirus that causes chikungunya fever, a severe, debilitating disease that often produces chronic arthralgia. Since 2004, CHIKV has emerged in Africa, Indian Ocean islands, Asia, Europe, and the Americas, causing millions of human infections. Central to understanding CHIKV emergence is knowledge of the natural ecology of transmission and vector infection dynamics. This review presents current understanding of CHIKV infection dynamics in mosquito vectors and its relationship to human disease emergence. The following topics are reviewed: CHIKV infection and vector life history traits including transmission cycles, genetic origins, distribution, emergence and spread, dispersal, vector competence, vector immunity and microbial interactions, and co-infection by CHIKV and other arboviruses. The genetics of vector susceptibility and host range changes, population heterogeneity and selection for the fittest viral genomes, dual host cycling and its impact on CHIKV adaptation, viral bottlenecks and intrahost diversity, and adaptive constraints on CHIKV evolution are also discussed. The potential for CHIKV re-emergence and expansion into new areas and prospects for prevention via vector control are also briefly reviewed.

  5. Stable piecewise polynomial vector fields

    Directory of Open Access Journals (Sweden)

    Claudio Pessoa

    2012-09-01

    Full Text Available Let $N={y>0}$ and $S={y<0}$ be the semi-planes of $mathbb{R}^2$ having as common boundary the line $D={y=0}$. Let $X$ and $Y$ be polynomial vector fields defined in $N$ and $S$, respectively, leading to a discontinuous piecewise polynomial vector field $Z=(X,Y$. This work pursues the stability and the transition analysis of solutions of $Z$ between $N$ and $S$, started by Filippov (1988 and Kozlova (1984 and reformulated by Sotomayor-Teixeira (1995 in terms of the regularization method. This method consists in analyzing a one parameter family of continuous vector fields $Z_{epsilon}$, defined by averaging $X$ and $Y$. This family approaches $Z$ when the parameter goes to zero. The results of Sotomayor-Teixeira and Sotomayor-Machado (2002 providing conditions on $(X,Y$ for the regularized vector fields to be structurally stable on planar compact connected regions are extended to discontinuous piecewise polynomial vector fields on $mathbb{R}^2$. Pertinent genericity results for vector fields satisfying the above stability conditions are also extended to the present case. A procedure for the study of discontinuous piecewise vector fields at infinity through a compactification is proposed here.

  6. Chikungunya Virus–Vector Interactions

    Science.gov (United States)

    Coffey, Lark L.; Failloux, Anna-Bella; Weaver, Scott C.

    2014-01-01

    Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes chikungunya fever, a severe, debilitating disease that often produces chronic arthralgia. Since 2004, CHIKV has emerged in Africa, Indian Ocean islands, Asia, Europe, and the Americas, causing millions of human infections. Central to understanding CHIKV emergence is knowledge of the natural ecology of transmission and vector infection dynamics. This review presents current understanding of CHIKV infection dynamics in mosquito vectors and its relationship to human disease emergence. The following topics are reviewed: CHIKV infection and vector life history traits including transmission cycles, genetic origins, distribution, emergence and spread, dispersal, vector competence, vector immunity and microbial interactions, and co-infection by CHIKV and other arboviruses. The genetics of vector susceptibility and host range changes, population heterogeneity and selection for the fittest viral genomes, dual host cycling and its impact on CHIKV adaptation, viral bottlenecks and intrahost diversity, and adaptive constraints on CHIKV evolution are also discussed. The potential for CHIKV re-emergence and expansion into new areas and prospects for prevention via vector control are also briefly reviewed. PMID:25421891

  7. Reducing Support Vector Machine Classification Error by Implementing Kalman Filter

    Directory of Open Access Journals (Sweden)

    Muhsin Hassan

    2013-08-01

    Full Text Available The aim of this is to demonstrate the capability of Kalman Filter to reduce Support Vector Machine classification errors in classifying pipeline corrosion depth. In pipeline defect classification, it is important to increase the accuracy of the SVM classification so that one can avoid misclassification which can lead to greater problems in monitoring pipeline defect and prediction of pipeline leakage. In this paper, it is found that noisy data can greatly affect the performance of SVM. Hence, Kalman Filter + SVM hybrid technique has been proposed as a solution to reduce SVM classification errors. The datasets has been added with Additive White Gaussian Noise in several stages to study the effect of noise on SVM classification accuracy. Three techniques have been studied in this experiment, namely SVM, hybrid of Discrete Wavelet Transform + SVM and hybrid of Kalman Filter + SVM. Experiment results have been compared to find the most promising techniques among them. MATLAB simulations show Kalman Filter and Support Vector Machine combination in a single system produced higher accuracy compared to the other two techniques.

  8. Vector control of induction machines

    CERN Document Server

    Robyns, Benoit

    2012-01-01

    After a brief introduction to the main law of physics and fundamental concepts inherent in electromechanical conversion, ""Vector Control of Induction Machines"" introduces the standard mathematical models for induction machines - whichever rotor technology is used - as well as several squirrel-cage induction machine vector-control strategies. The use of causal ordering graphs allows systematization of the design stage, as well as standardization of the structure of control devices. ""Vector Control of Induction Machines"" suggests a unique approach aimed at reducing parameter sensitivity for

  9. Vector fields on nonorientable surfaces

    Directory of Open Access Journals (Sweden)

    Dorin Ghisa

    2003-01-01

    Full Text Available A one-to-one correspondence is established between the germs of functions and tangent vectors on a NOS X and the bi-germs of functions, respectively, elementary fields of tangent vectors (EFTV on the orientable double cover of X. Some representation theorems for the algebra of germs of functions, the tangent space at an arbitrary point of X, and the space of vector fields on X are proved by using a symmetrisation process. An example related to the normal derivative on the border of the Möbius strip supports the nontriviality of the concepts introduced in this paper.

  10. On the Witt vector Frobenius

    DEFF Research Database (Denmark)

    Davis, Christopher James; Kedlaya, Kiran

    2014-01-01

    We study the kernel and cokernel of the Frobenius map on the p-typical Witt vectors of a commutative ring, not necessarily of characteristic p. We give many equivalent conditions to surjectivity of the Frobenius map on both finite and infinite length Witt vectors. In particular, surjectivity...... on finite Witt vectors turns out to be stable under certain integral extensions; this provides a clean formulation of a strong generalization of Faltings’s almost purity theorem from p-adic Hodge theory, incorporating recent improvements by Kedlaya–Liu and by Scholze....

  11. Vector boson scattering at CLIC

    Energy Technology Data Exchange (ETDEWEB)

    Kilian, Wolfgang; Fleper, Christian [Department Physik, Universitaet Siegen, 57068 Siegen (Germany); Reuter, Juergen [DESY Theory Group, 22603 Hamburg (Germany); Sekulla, Marco [Institut fuer Theoretische Physik, Karlsruher Institut fuer Technologie, 76131 Karlsruhe (Germany)

    2016-07-01

    Linear colliders operating in a range of multiple TeV are able to investigate the details of vector boson scattering and electroweak symmetry breaking. We calculate cross sections with the Monte Carlo generator WHIZARD for vector boson scattering processes at the future linear e{sup +} e{sup -} collider CLIC. By finding suitable cuts, the vector boson scattering signal processes are isolated from the background. Finally, we are able to determine exclusion sensitivities on the non-Standard Model parameters of the relevant dimension eight operators.

  12. Synthetic Aperture Vector Flow Imaging

    DEFF Research Database (Denmark)

    Oddershede, Niels

    2008-01-01

    of the thesis considers a method for estimating the two-dimensional velocity vector within the image plane. This method, called synthetic aperture vector flow imaging, is first shortly reviewed. The main contribution of this work is partly an analysis of the method with respect to focusing effects, motion...... estimation. The method can be used for increasing the frame rate of color flow maps or alternatively for a new imaging modality entitled quadroplex imaging, featuring a color flow map and two independent spectrograms at a high frame rate. The second is an alternative method for ultrasonic vector velocity...

  13. On the Witt vector Frobenius

    DEFF Research Database (Denmark)

    Davis, Christopher James; Kedlaya, Kiran

    2014-01-01

    We study the kernel and cokernel of the Frobenius map on the p-typical Witt vectors of a commutative ring, not necessarily of characteristic p. We give many equivalent conditions to surjectivity of the Frobenius map on both finite and infinite length Witt vectors. In particular, surjectivity...... on finite Witt vectors turns out to be stable under certain integral extensions; this provides a clean formulation of a strong generalization of Faltings’s almost purity theorem from p-adic Hodge theory, incorporating recent improvements by Kedlaya–Liu and by Scholze....

  14. ADОPTIVE CONTROL OF THE HYBRID VEHICLE POWER UNIT

    Directory of Open Access Journals (Sweden)

    S. Serikov

    2014-10-01

    Full Text Available The problem of adaptive control of the hybrid vehicle power unit, which makes it possible to minimize the quality criterion under constraints on the state parameters and the control vector is considered. A formal statement of the optimization problem is given. The solution of this problem by the method of neural network control based on the adaptive criticism is considered.

  15. Immunogenic Subviral Particles Displaying Domain III of Dengue 2 Envelope Protein Vectored by Measles Virus

    Directory of Open Access Journals (Sweden)

    Indira S. Harahap-Carrillo

    2015-07-01

    Full Text Available Vaccines against dengue virus (DV are commercially nonexistent. A subunit vaccination strategy may be of value, especially if a safe viral vector acts as biologically active adjuvant. In this paper, we focus on an immunoglobulin-like, independently folded domain III (DIII from DV 2 envelope protein (E, which contains epitopes that elicits highly specific neutralizing antibodies. We modified the hepatitis B small surface antigen (HBsAg, S in order to display DV 2 DIII on a virus-like particle (VLP, thus generating the hybrid antigen DIII-S. Two varieties of measles virus (MV vectors were developed to express DIII-S. The first expresses the hybrid antigen from an additional transcription unit (ATU and the second additionally expresses HBsAg from a separate ATU. We found that this second MV vectoring the hybrid VLPs displaying DIII-S on an unmodified HBsAg scaffold were immunogenic in MV-susceptible mice (HuCD46Ge-IFNarko, eliciting robust neutralizing responses (averages against MV (1:1280 NT90, hepatitis B virus (787 mIU/mL, and DV2 (1:160 NT50 in all of the tested animals. Conversely, the MV vector expressing only DIII-S induced immunity against MV alone. In summary, DV2 neutralizing responses can be generated by displaying E DIII on a scaffold of HBsAg-based VLPs, vectored by MV.

  16. Transcriptional Silencing of Retroviral Vectors

    DEFF Research Database (Denmark)

    Lund, Anders Henrik; Duch, M.; Pedersen, F.S.

    1996-01-01

    . Extinction of long-term vector expression has been observed after implantation of transduced hematopoietic cells as well as fibroblasts, myoblasts and hepatocytes. Here we review the influence of vector structure, integration site and cell type on transcriptional silencing. While down-regulation of proviral...... transcription is known from a number of cellular and animal models, major insight has been gained from studies in the germ line and embryonal cells of the mouse. Key elements for the transfer and expression of retroviral vectors, such as the viral transcriptional enhancer and the binding site for the t......RNA primer for reverse transcription may have a major influence on transcriptional silencing. Alterations of these elements of the vector backbone as well as the use of internal promoter elements from housekeeping genes may contribute to reduce transcriptional silencing. The use of cell culture and animal...

  17. Acoustic vector sensor signal processing

    Institute of Scientific and Technical Information of China (English)

    SUN Guiqing; LI Qihu; ZHANG Bin

    2006-01-01

    Acoustic vector sensor simultaneously, colocately and directly measures orthogonal components of particle velocity as well as pressure at single point in acoustic field so that is possible to improve performance of traditional underwater acoustic measurement devices or detection systems and extends new ideas for solving practical underwater acoustic engineering problems. Although acoustic vector sensor history of appearing in underwater acoustic area is no long, but with huge and potential military demands, acoustic vector sensor has strong development trend in last decade, it is evolving into a one of important underwater acoustic technology. Under this background, we try to review recent progress in study on acoustic vector sensor signal processing, such as signal detection, DOA estimation, beamforming, and so on.

  18. Introduction to matrices and vectors

    CERN Document Server

    Schwartz, Jacob T

    2001-01-01

    In this concise undergraduate text, the first three chapters present the basics of matrices - in later chapters the author shows how to use vectors and matrices to solve systems of linear equations. 1961 edition.

  19. GRE Enzymes for Vector Analysis

    Data.gov (United States)

    U.S. Environmental Protection Agency — Microbial enzyme data that were collected during the 2004-2006 EMAP-GRE program. These data were then used by Moorhead et al (2016) in their ecoenzyme vector...

  20. All optical vector magnetometer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I research project will investigate a novel method of operating an atomic magnetometer to simultaneously measure total magnetic fields and vector magnetic...

  1. Unsupervised learning of binary vectors

    Science.gov (United States)

    Copelli Lopes da Silva, Mauro

    In this thesis, unsupervised learning of binary vectors from data is studied using methods from Statistical Mechanics of disordered systems. In the model, data vectors are distributed according to a single symmetry-breaking direction. The aim of unsupervised learning is to provide a good approximation to this direction. The difference with respect to previous studies is the knowledge that this preferential direction has binary components. It is shown that sampling from the posterior distribution (Gibbs learning) leads, for general smooth distributions, to an exponentially fast approach to perfect learning in the asymptotic limit of large number of examples. If the distribution is non-smooth, then first order phase transitions to perfect learning are expected. In the limit of poor performance, a second order phase transition ("retarded learning") is predicted to occur if the data distribution is not biased. Using concepts from Bayesian inference, the center of mass of the Gibbs ensemble is shown to have maximal average (Bayes-optimal) performance. This upper bound for continuous vectors is extended to a discrete space, resulting in the clipped center of mass of the Gibbs ensemble having maximal average performance among the binary vectors. To calculate the performance of this best binary vector, the geometric properties of the center of mass of binary vectors are studied. The surprising result is found that the center of mass of infinite binary vectors which obey some simple constraints, is again a binary vector. When disorder is taken into account in the calculation, however, a vector with continuous components is obtained. The performance of the best binary vector is calculated and shown to always lie above that of Gibbs learning and below the Bayes-optimal performance. Making use of a variational approach under the replica symmetric ansatz, an optimal potential is constructed in the limits of zero temperature and mutual overlap 1. Minimization of this potential

  2. Decays of the vector glueball

    CERN Document Server

    Giacosa, Francesco; Janowski, Stanislaus

    2016-01-01

    We calculate two- and three-body decays of the (lightest) vector glueball into (pseudo)scalar, (axial-)vector, as well as pseudovector and excited vector mesons. By setting the mass of this yet hypothetical vector glueball to 3.8 GeV as predicted by Lattice QCD, many branching ratios can be computed and represent a parameter-free prediction of our approach. We find that the decay mode $\\omega\\pi\\pi$ should be one of the largest (both through the decay chain $\\mathcal{O}\\rightarrow b_{1}\\pi\\rightarrow$ $\\omega\\pi\\pi$ and through the direct coupling $\\mathcal{O}\\rightarrow\\omega\\pi\\pi$)$.$ Similarly, the (direct and indirect) decay into $\\pi KK^{\\ast}(892)$ is sizable. Moreover, the decays into $\\rho\\pi$ and $K^{\\ast}(892)K$ are, although subleading, possible and could play a role in explaining the $\\rho\\pi$ puzzle of the charmonium state $\\psi(2S)$ thank to a (small) mixing with the vector glueball. The vector glueball can be directly formed at the ongoing BESIII experiment as well as at the future PANDA exper...

  3. Handling S/MAR vectors.

    Science.gov (United States)

    Hagedorn, Claudia; Baiker, Armin; Postberg, Jan; Ehrhardt, Anja; Lipps, Hans J

    2012-06-01

    Nonviral episomal vectors represent attractive alternatives to currently used virus-based expression systems. In the late 1990s, it was shown that a plasmid containing an expression cassette linked to a scaffold/matrix attached region (S/MAR) replicates as a low copy number episome in all cell lines tested, as well as primary cells, and can be used for the genetic modification of higher animals. Once established in the cell, the S/MAR vector replicates early during S-phase and, in the absence of selection, is stably retained in the cells for an unlimited period of time. This vector can therefore be regarded as a minimal model system for studying the epigenetic regulation of replication and functional nuclear architecture. In theory, this construct represents an almost "ideal" expression system for gene therapy. In practice, S/MAR-based vectors stably modify mammalian cells with efficiencies far below those of virus-based constructs. Consequently, they have not yet found application in gene therapy trials. Furthermore, S/MAR vector systems are not trivial to handle and several critical technical issues have to be considered when modifying these vectors for various applications.

  4. Product demand forecasts using wavelet kernel support vector machine and particle swarm optimization in manufacture system

    Science.gov (United States)

    Wu, Qi

    2010-03-01

    Demand forecasts play a crucial role in supply chain management. The future demand for a certain product is the basis for the respective replenishment systems. Aiming at demand series with small samples, seasonal character, nonlinearity, randomicity and fuzziness, the existing support vector kernel does not approach the random curve of the sales time series in the space (quadratic continuous integral space). In this paper, we present a hybrid intelligent system combining the wavelet kernel support vector machine and particle swarm optimization for demand forecasting. The results of application in car sale series forecasting show that the forecasting approach based on the hybrid PSOWv-SVM model is effective and feasible, the comparison between the method proposed in this paper and other ones is also given, which proves that this method is, for the discussed example, better than hybrid PSOv-SVM and other traditional methods.

  5. Direct numerical simulation of vector-controlled free jets

    Energy Technology Data Exchange (ETDEWEB)

    Tsujimoto, K; Ao, K; Shakouchi, T; Ando, T, E-mail: tujimoto@mach.mie-u.ac.jp [Graduate School of Engineering, Mie University, Tsu, 514-8507 (Japan)

    2011-12-22

    We conduct DNS (direct numerical simulation) of vector controlled free jets. The inflow velocity of jet is periodically oscillated perpendicular to the jet axis. In order to realize the high accurate computation, a discretization in space is performed with hybrid scheme in which Fourier spectral and 6th order compact scheme are adopted. From visualized instantaneous vortex structures, it is found that the flow pattern considerably changes according to the oscillating frequency, i.e., according to the increasing the frequency, wave, bifurcating and flapping modes appear in turn. In order to quantify mixing efficiency under the vector control, as the mixing measure, statistical entropy is investigated. Compared to the uncontrolled jet, the mixing efficiency is improved in order of wavy, flapping and bifurcating modes. Thus the vector control can be expected for the improvement of mixing efficiency. Further to make clear the reason for the mixing enhancement, Snapshot POD and DMD method are applied. The primary flow structures under the vector control are demonstrated.

  6. Viral vectors for targeting the canine retina: a review.

    Science.gov (United States)

    Petersen-Jones, Simon M

    2012-09-01

    Clinical trials are currently underway using gene therapy to treat retinal disease such as Leber congenital amaurosis (LCA). Viral vectors that have been utilized to target retinal cells include adenoviruses, lentiviruses, and recombinant adeno-associated viruses (rAAV). Of the three classes, rAAV vectors show the greatest promise for retinal gene therapy. Recent developments in virus technology such as the development of hybrid and capsid mutant rAAV vectors mean that specific retinal cells can be targeted and faster stronger transgene expression is now possible compared to that achieved with the first generation of vectors. Gene therapy trials in dogs have been very important in the development of therapy for RPE65 LCA which is currently in phase I/II clinical trials in humans. Recent successes in using gene therapy to treat canine achromatopsia, X-linked progressive retinal atrophy (PRA) and the more severe rapid degenerations such as rod-cone dysplasia type 3 may lead also to the translation to human clinical trials. Dogs have played and continue to play an important role as animal models for proof-of-concept studies of retinal gene therapy. As modifications and improvements in gene therapy protocols are made from experience gathered from human clinical trials perhaps gene therapy for the treatment of canine clinical patients will become available to veterinary ophthalmologists. © 2012 American College of Veterinary Ophthalmologists.

  7. Engineering semiconductor hybrids for sensing

    Science.gov (United States)

    Gumbs, Godfrey; Iurov, Andrii; Huang, Danhong

    2016-06-01

    The effect of screening of the coulomb interaction between two layers of two-dimensional electrons, such as in graphene, by a highly doped semiconducting substrate is investigated. We employ the random-phase approximation to calculate the dispersion equation of this hybrid structure in order to determine the plasmon excitation spectrum. When an electric current is passed through a layer, the low-frequency plasmons in the layer may bifurcate into separate streams due to the current-driving effect. At a critical wave vector, determined by the separation between layers and their distance from the surface, their phase velocities may be in opposite directions and a surface plasmon instability leads to the emission of radiation. Applications to detectors and other electromagnetic devices exploiting nano-plasmonics are discussed.

  8. Are Bred Vectors The Same As Lyapunov Vectors?

    Science.gov (United States)

    Kalnay, E.; Corazza, M.; Cai, M.

    Regional loss of predictability is an indication of the instability of the underlying flow, where small errors in the initial conditions (or imperfections in the model) grow to large amplitudes in finite times. The stability properties of evolving flows have been studied using Lyapunov vectors (e.g., Alligood et al, 1996, Ott, 1993, Kalnay, 2002), singular vectors (e.g., Lorenz, 1965, Farrell, 1988, Molteni and Palmer, 1993), and, more recently, with bred vectors (e.g., Szunyogh et al, 1997, Cai et al, 2001). Bred vectors (BVs) are, by construction, closely related to Lyapunov vectors (LVs). In fact, after an infinitely long breeding time, and with the use of infinitesimal ampli- tudes, bred vectors are identical to leading Lyapunov vectors. In practical applications, however, bred vectors are different from Lyapunov vectors in two important ways: a) bred vectors are never globally orthogonalized and are intrinsically local in space and time, and b) they are finite-amplitude, finite-time vectors. These two differences are very significant in a dynamical system whose size is very large. For example, the at- mosphere is large enough to have "room" for several synoptic scale instabilities (e.g., storms) to develop independently in different regions (say, North America and Aus- tralia), and it is complex enough to have several different possible types of instabilities (such as barotropic, baroclinic, convective, and even Brownian motion). Bred vectors share some of their properties with leading LVs (Corazza et al, 2001a, 2001b, Toth and Kalnay, 1993, 1997, Cai et al, 2001). For example, 1) Bred vectors are independent of the norm used to define the size of the perturba- tion. Corazza et al. (2001) showed that bred vectors obtained using a potential enstro- phy norm were indistinguishable from bred vectors obtained using a streamfunction squared norm, in contrast with singular vectors. 2) Bred vectors are independent of the length of the rescaling period as long as the

  9. Deriving Potential Coronal Magnetic Fields from Vector Magnetograms

    Science.gov (United States)

    Welsch, Brian T.; Fisher, George H.

    2016-08-01

    The minimum-energy configuration for the magnetic field above the solar photosphere is curl-free (hence, by Ampère's law, also current-free), so can be represented as the gradient of a scalar potential. Since magnetic fields are divergence free, this scalar potential obeys Laplace's equation, given an appropriate boundary condition (BC). With measurements of the full magnetic vector at the photosphere, it is possible to employ either Neumann or Dirichlet BCs there. Historically, the Neumann BC was used with available line-of-sight magnetic field measurements, which approximate the radial field needed for the Neumann BC. Since each BC fully determines the 3D vector magnetic field, either choice will, in general, be inconsistent with some aspect of the observed field on the boundary, due to the presence of both currents and noise in the observed field. We present a method to combine solutions from both Dirichlet and Neumann BCs to determine a hybrid, "least-squares" potential field, which minimizes the integrated square of the residual between the potential and actual fields. We also explore weighting the residuals in the fit by spatially uniform measurement uncertainties. This has advantages both in not overfitting the radial field used for the Neumann BC, and in maximizing consistency with the observations. We demonstrate our methods with SDO/HMI vector magnetic field observations of active region 11158, and find that residual discrepancies between the observed and potential fields are significant, and they are consistent with nonzero horizontal photospheric currents. We also analyze potential fields for two other active regions observed with two different vector magnetographs, and find that hybrid-potential fields have significantly less energy than the Neumann fields in every case - by more than 10^{32} erg in some cases. This has major implications for estimates of free magnetic energy in coronal field models, e.g., non-linear force-free field extrapolations.

  10. Protective Bystander Effects Simulated with the State-Vector Model

    OpenAIRE

    Schöllnberger, Helmut; Peter M. Eckl

    2007-01-01

    Apoptosis induced in non-hit bystander cells is an important biological mechanism which operates after exposure to low doses of low-LET radiation. This process was implemented into a deterministic multistage model for in vitro neoplastic transformation: the State-Vector Model (SVM). The new model is tested on two data sets that show a reduction of the transformation frequency below the spontaneous level after exposure of the human hybrid cell line CGL1 to low doses of γ-radiation. Stronger pr...

  11. Containment of arthropod disease vectors.

    Science.gov (United States)

    Scott, Thomas W

    2005-01-01

    Effective containment of arthropod vectors of infectious diseases is necessary to prevent transmission of pathogens by released, infected vectors and to prevent vectors that escape from establishing populations that subsequently contribute to increased disease. Although rare, past releases illustrate what can go wrong and justify the need for guidelines that minimize risks. An overview of recommendations for insectary facilities, practices, and equipment is provided, and features of four recently published and increasingly rigorous arthropod containment levels (ACLs 1-4) are summarized. ACL-1 is appropriate for research that constitutes the lowest risk level, including uninfected arthropods or vectors that are infected with micro-organisms that do not cause disease in humans, domestic animals, or wildlife. ACL-2 is appropriate for indigenous and exotic arthropods that represent a moderate risk, including vectors infected or suspected of being infected with biosafety level (BSL)-2 infectious agents and arthropods that have been genetically modified in ways that do not significantly affect their fecundity, survival, host preference, or vector competence. ACL-3 is recommended for arthropods that are or may be infected with BSL-3 infectious agents. ACL-3 places greater emphasis on pathogen containment and more restricted access to the insectary than ACL-2. ACL-4 is intended for arthropods that are infected with the most dangerous BSL-4 infectious agents, which can cause life-threatening illness by aerosol or arthropod bite. Adherence to these guidelines will result in laboratory-based arthropod vector research that minimizes risks and results in important new contributions to applied and basic science.

  12. Black holes with vector hair

    Science.gov (United States)

    Fan, Zhong-Ying

    2016-09-01

    In this paper, we consider Einstein gravity coupled to a vector field, either minimally or non-minimally, together with a vector potential of the type V = 2{Λ}_0+1/2{m}^2{A}^2 + {γ}_4{A}^4 . For a simpler non-minimally coupled theory with Λ0 = m = γ4 = 0, we obtain both extremal and non-extremal black hole solutions that are asymptotic to Minkowski space-times. We study the global properties of the solutions and derive the first law of thermodynamics using Wald formalism. We find that the thermodynamical first law of the extremal black holes is modified by a one form associated with the vector field. In particular, due to the existence of the non-minimal coupling, the vector forms thermodynamic conjugates with the graviton mode and partly contributes to the one form modifying the first law. For a minimally coupled theory with Λ0 ≠ 0, we also obtain one class of asymptotically flat extremal black hole solutions in general dimensions. This is possible because the parameters ( m 2 , γ4) take certain values such that V = 0. In particular, we find that the vector also forms thermodynamic conjugates with the graviton mode and contributes to the corresponding first law, although the non-minimal coupling has been turned off. Thus all the extremal black hole solutions that we obtain provide highly non-trivial examples how the first law of thermodynamics can be modified by a either minimally or non-minimally coupled vector field. We also study Gauss-Bonnet gravity non-minimally coupled to a vector and obtain asymptotically flat black holes and Lifshitz black holes.

  13. Decays of the vector glueball

    Science.gov (United States)

    Giacosa, Francesco; Sammet, Julia; Janowski, Stanislaus

    2017-06-01

    We calculate two- and three-body decays of the (lightest) vector glueball into (pseudo)scalar, (axial-)vector, as well as pseudovector and excited vector mesons in the framework of a model of QCD. While absolute values of widths cannot be predicted because the corresponding coupling constants are unknown, some interesting branching ratios can be evaluated by setting the mass of the yet hypothetical vector glueball to 3.8 GeV as predicted by quenched lattice QCD. We find that the decay mode ω π π should be one of the largest (both through the decay chain O →b1π →ω π π and through the direct coupling O →ω π π ). Similarly, the (direct and indirect) decay into π K K*(892 ) is sizable. Moreover, the decays into ρ π and K*(892 )K are, although subleading, possible and could play a role in explaining the ρ π puzzle of the charmonium state ψ (2 S ) thanks to a (small) mixing with the vector glueball. The vector glueball can be directly formed at the ongoing BESIII experiment as well as at the future PANDA experiment at the FAIR facility. If the width is sufficiently small (≲100 MeV ) it should not escape future detection. It should be stressed that the employed model is based on some inputs and simplifying assumptions: the value of glueball mass (at present, the quenched lattice value is used), the lack of mixing of the glueball with other quarkonium states, and the use of few interaction terms. It then represents a first step toward the identification of the main decay channels of the vector glueball, but shall be improved when corresponding experimental candidates and/or new lattice results will be available.

  14. River flow time series using least squares support vector machines

    Science.gov (United States)

    Samsudin, R.; Saad, P.; Shabri, A.

    2011-06-01

    This paper proposes a novel hybrid forecasting model known as GLSSVM, which combines the group method of data handling (GMDH) and the least squares support vector machine (LSSVM). The GMDH is used to determine the useful input variables which work as the time series forecasting for the LSSVM model. Monthly river flow data from two stations, the Selangor and Bernam rivers in Selangor state of Peninsular Malaysia were taken into consideration in the development of this hybrid model. The performance of this model was compared with the conventional artificial neural network (ANN) models, Autoregressive Integrated Moving Average (ARIMA), GMDH and LSSVM models using the long term observations of monthly river flow discharge. The root mean square error (RMSE) and coefficient of correlation (R) are used to evaluate the models' performances. In both cases, the new hybrid model has been found to provide more accurate flow forecasts compared to the other models. The results of the comparison indicate that the new hybrid model is a useful tool and a promising new method for river flow forecasting.

  15. A NOTE ON VECTOR CASCADE ALGORITHM

    Institute of Scientific and Technical Information of China (English)

    Qiu-hui Chen; Jin-zhao Liu; Wen-sheng Zhang

    2002-01-01

    The focus of this paper is on the relationship between accuracy of multivariate refinable vector and vector cascade algorithm. We show that, if the vector cascade algorithm (1.5) with isotropic dilation converges to a vector-valued function with regularity, then the initial function must satisfy the Strang-Fix conditions.

  16. Project Physics Programmed Instruction, Vectors 1.

    Science.gov (United States)

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    This programmed instruction booklet is an interim version of instructional materials being developed by Harvard Project Physics. It is the first in a series of three booklets on vectors and covers the definitions of vectors and scalars, drawing vector quantities to scale, and negative vectors. For others in this series, see SE 015 550 and SE 015…

  17. Project Physics Programmed Instruction, Vectors 2.

    Science.gov (United States)

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    This is the second of a series of three programmed instruction booklets on vectors developed by Harvard Project Physics. It covers adding two or more vectors together, and finding a third vector that could be added to two given vectors to make a sum of zero. For other booklets in this series, see SE 015 549 and SE 015 551. (DT)

  18. The Duality on Vector Optimization Problems

    Institute of Scientific and Technical Information of China (English)

    HUANG Long-guang

    2012-01-01

    Duality framework on vector optimization problems in a locally convex topological vector space are established by using scalarization with a cone-strongly increasing function.The dualities for the scalar convex composed optimization problems and for general vector optimization problems are studied.A general approach for studying duality in vector optimization problems is presented.

  19. The biological control of disease vectors.

    Science.gov (United States)

    Okamoto, Kenichi W; Amarasekare, Priyanga

    2012-09-21

    Vector-borne diseases are common in nature and can have a large impact on humans, livestock and crops. Biological control of vectors using natural enemies or competitors can reduce vector density and hence disease transmission. However, the indirect interactions inherent in host-vector disease systems make it difficult to use traditional pest control theory to guide biological control of disease vectors. This necessitates a conceptual framework that explicitly considers a range of indirect interactions between the host-vector disease system and the vector's biological control agent. Here we conduct a comparative analysis of the efficacy of different types of biological control agents in controlling vector-borne diseases. We report three key findings. First, highly efficient predators and parasitoids of the vector prove to be effective biological control agents, but highly virulent pathogens of the vector also require a high transmission rate to be effective. Second, biocontrol agents can successfully reduce long-term host disease incidence even though they may fail to reduce long-term vector densities. Third, inundating a host-vector disease system with a natural enemy of the vector has little or no effect on reducing disease incidence, but inundating the system with a competitor of the vector has a large effect on reducing disease incidence. The comparative framework yields predictions that are useful in developing biological control strategies for vector-borne diseases. We discuss how these predictions can inform ongoing biological control efforts for host-vector disease systems.

  20. Circuit QED with hybrid metamaterial transmission lines

    Energy Technology Data Exchange (ETDEWEB)

    Ruloff, Stefan; Taketani, Bruno; Wilhelm, Frank [Theoretical Physics, Universitaet des Saarlandes, Saarbruecken (Germany)

    2016-07-01

    We're working on the theory of metamaterials providing some interesting results. The negative refraction index causes an opposite orientation of the wave vector k and the Poynting vector S of the travelling waves. Hence the metamaterial has a falling dispersion relation ∂ω(k)/∂k < 0 implying that low frequencies correspond to short wavelengths. Metamaterials are simulated by left-handed transmission lines consisting of discrete arrays of series capacitors and parallel inductors to ground. Unusual physics arises when right-and left-handed transmission lines are coupled forming a hybrid metamaterial transmission line. E.g. if a qubit is placed in front of a hybrid metamaterial transmission line terminated in an open circuit, the spontaneous emission rate is weakened or unaffected depending on the transition frequency of the qubit. Some other research interests are the general analysis of metamaterial cavities and the mode structure of hybrid metamaterial cavities for QND readout of multi-qubit operators. Especially the precise answer to the question about the definition of the mode volume of a metamaterial cavity is one of our primary goals.

  1. From hybrid swarms to swarms of hybrids

    Science.gov (United States)

    The introgression of modern humans (Homo sapiens) with Neanderthals 40,000 YBP after a half-million years of separation, may have led to the best example of a hybrid swarm on earth. Modern trade and transportation in support of the human hybrids has continued to introduce additional species, genotyp...

  2. The Hybrid Museum: Hybrid Economies of Meaning

    DEFF Research Database (Denmark)

    Vestergaard, Vitus

    2013-01-01

    this article shows that there are two different museum mindsets where the second mindset leans towards participatory practices. It is shown how a museum can support a hybrid economy of meaning that builds on both a user generated economy of meaning and an institutional economy of meaning and adds value to both....... Such a museum is referred to as a hybrid museum....

  3. Hydraulic Hybrid Vehicles

    Science.gov (United States)

    EPA and the United Parcel Service (UPS) have developed a hydraulic hybrid delivery vehicle to explore and demonstrate the environmental benefits of the hydraulic hybrid for urban pick-up and delivery fleets.

  4. Hybrid Management in Hospitals

    DEFF Research Database (Denmark)

    Byrkjeflot, Haldor; Jespersen, Peter Kragh

    2010-01-01

    Artiklen indeholder et litteraturbaseret studium af ledelsesformer i sygehuse, hvor sundhedsfaglig ledelse og generel ledelse mikses til hybride ledelsesformer......Artiklen indeholder et litteraturbaseret studium af ledelsesformer i sygehuse, hvor sundhedsfaglig ledelse og generel ledelse mikses til hybride ledelsesformer...

  5. Vector-valued automorphic forms and vector bundles

    CERN Document Server

    Saber, Hicham

    2013-01-01

    For an arbitrary discrete group $\\Gamma$ and an $n$-dimensional complex representation $R$ of $\\Gamma$, we prove the existence of $n$ linearly independent vector-valued automorphic forms for $\\Gamma$ with multiplier $R$. To this end, we realize these automorphic forms as sections of a rank $n$ vector bundle attached to a 1-cocycle with coefficients in the sheaf $\\mbox{GL}(n,{\\mathcal O}_X)$, $X$ being the quotient of the Poincar\\'e half-plane by $\\Gamma$ completed with the cusps of $\\Gamma$.

  6. Implementing Bayesian Vector Autoregressions Implementing Bayesian Vector Autoregressions

    Directory of Open Access Journals (Sweden)

    Richard M. Todd

    1988-03-01

    Full Text Available Implementing Bayesian Vector Autoregressions This paper discusses how the Bayesian approach can be used to construct a type of multivariate forecasting model known as a Bayesian vector autoregression (BVAR. In doing so, we mainly explain Doan, Littermann, and Sims (1984 propositions on how to estimate a BVAR based on a certain family of prior probability distributions. indexed by a fairly small set of hyperparameters. There is also a discussion on how to specify a BVAR and set up a BVAR database. A 4-variable model is used to iliustrate the BVAR approach.

  7. Vector Encoding in Biochemical Networks

    Science.gov (United States)

    Potter, Garrett; Sun, Bo

    Encoding of environmental cues via biochemical signaling pathways is of vital importance in the transmission of information for cells in a network. The current literature assumes a single cell state is used to encode information, however, recent research suggests the optimal strategy utilizes a vector of cell states sampled at various time points. To elucidate the optimal sampling strategy for vector encoding, we take an information theoretic approach and determine the mutual information of the calcium signaling dynamics obtained from fibroblast cells perturbed with different concentrations of ATP. Specifically, we analyze the sampling strategies under the cases of fixed and non-fixed vector dimension as well as the efficiency of these strategies. Our results show that sampling with greater frequency is optimal in the case of non-fixed vector dimension but that, in general, a lower sampling frequency is best from both a fixed vector dimension and efficiency standpoint. Further, we find the use of a simple modified Ornstein-Uhlenbeck process as a model qualitatively captures many of our experimental results suggesting that sampling in biochemical networks is based on a few basic components.

  8. Ensemble Dynamics and Bred Vectors

    CERN Document Server

    Balci, Nusret; Restrepo, Juan M; Sell, George R

    2011-01-01

    We introduce the new concept of an EBV to assess the sensitivity of model outputs to changes in initial conditions for weather forecasting. The new algorithm, which we call the "Ensemble Bred Vector" or EBV, is based on collective dynamics in essential ways. By construction, the EBV algorithm produces one or more dominant vectors. We investigate the performance of EBV, comparing it to the BV algorithm as well as the finite-time Lyapunov Vectors. We give a theoretical justification to the observed fact that the vectors produced by BV, EBV, and the finite-time Lyapunov vectors are similar for small amplitudes. Numerical comparisons of BV and EBV for the 3-equation Lorenz model and for a forced, dissipative partial differential equation of Cahn-Hilliard type that arises in modeling the thermohaline circulation, demonstrate that the EBV yields a size-ordered description of the perturbation field, and is more robust than the BV in the higher nonlinear regime. The EBV yields insight into the fractal structure of th...

  9. Resin Catalyst Hybrids

    Institute of Scientific and Technical Information of China (English)

    S. Asaoka

    2005-01-01

    @@ 1Introduction: What are resin catalyst hybrids? There are typically two types of resin catalyst. One is acidic resin which representative is polystyrene sulfonic acid. The other is basic resin which is availed as metal complex support. The objective items of this study on resin catalyst are consisting of pellet hybrid, equilibrium hybrid and function hybrid of acid and base,as shown in Fig. 1[1-5].

  10. Mesoscale hybrid calibration artifact

    Science.gov (United States)

    Tran, Hy D.; Claudet, Andre A.; Oliver, Andrew D.

    2010-09-07

    A mesoscale calibration artifact, also called a hybrid artifact, suitable for hybrid dimensional measurement and the method for make the artifact. The hybrid artifact has structural characteristics that make it suitable for dimensional measurement in both vision-based systems and touch-probe-based systems. The hybrid artifact employs the intersection of bulk-micromachined planes to fabricate edges that are sharp to the nanometer level and intersecting planes with crystal-lattice-defined angles.

  11. Realizing the Hybrid Library.

    Science.gov (United States)

    Pinfield, Stephen; Eaton, Jonathan; Edwards, Catherine; Russell, Rosemary; Wissenburg, Astrid; Wynne, Peter

    1998-01-01

    Outlines five projects currently funded by the United Kingdom's Electronic Libraries Program (eLib): HyLiFe (Hybrid Library of the Future), MALIBU (MAnaging the hybrid Library for the Benefit of Users), HeadLine (Hybrid Electronic Access and Delivery in the Library Networked Environment), ATHENS (authentication scheme), and BUILDER (Birmingham…

  12. Homoploid hybrid expectations

    Science.gov (United States)

    Homoploid hybrid speciation occurs when a stable, fertile, and reproductively isolated lineage results from hybridization between two distinct species without a change in ploidy level. Reproductive isolation between a homoploid hybrid species and its parents is generally attained via chromosomal re...

  13. Hybrid armature projectile

    Science.gov (United States)

    Hawke, Ronald S.; Asay, James R.; Hall, Clint A.; Konrad, Carl H.; Sauve, Gerald L.; Shahinpoor, Mohsen; Susoeff, Allan R.

    1993-01-01

    A projectile for a railgun that uses a hybrid armature and provides a seed block around part of the outer surface of the projectile to seed the hybrid plasma brush. In addition, the hybrid armature is continuously vaporized to replenish plasma in a plasma armature to provide a tandem armature and provides a unique ridge and groove to reduce plasama blowby.

  14. Intraply Hybrid Composite Design

    Science.gov (United States)

    Chamis, C. C.; Sinclair, J. H.

    1986-01-01

    Several theoretical approaches combined in program. Intraply hybrid composites investigated theoretically and experimentally at Lewis Research Center. Theories developed during investigations and corroborated by attendant experiments used to develop computer program identified as INHYD (Intraply Hybrid Composite Design). INHYD includes several composites micromechanics theories, intraply hybrid composite theories, and integrated hygrothermomechanical theory. Equations from theories used by program as appropriate for user's specific applications.

  15. Hybrid quantum information processing

    Energy Technology Data Exchange (ETDEWEB)

    Furusawa, Akira [Department of Applied Physics, School of Engineering, The University of Tokyo (Japan)

    2014-12-04

    I will briefly explain the definition and advantage of hybrid quantum information processing, which is hybridization of qubit and continuous-variable technologies. The final goal would be realization of universal gate sets both for qubit and continuous-variable quantum information processing with the hybrid technologies. For that purpose, qubit teleportation with a continuousvariable teleporter is one of the most important ingredients.

  16. Gauge Theories of Vector Particles

    Science.gov (United States)

    Glashow, S. L.; Gell-Mann, M.

    1961-04-24

    The possibility of generalizing the Yang-Mills trick is examined. Thus we seek theories of vector bosons invariant under continuous groups of coordinate-dependent linear transformations. All such theories may be expressed as superpositions of certain "simple" theories; we show that each "simple theory is associated with a simple Lie algebra. We may introduce mass terms for the vector bosons at the price of destroying the gauge-invariance for coordinate-dependent gauge functions. The theories corresponding to three particular simple Lie algebras - those which admit precisely two commuting quantum numbers - are examined in some detail as examples. One of them might play a role in the physics of the strong interactions if there is an underlying super-symmetry, transcending charge independence, that is badly broken. The intermediate vector boson theory of weak interactions is discussed also. The so-called "schizon" model cannot be made to conform to the requirements of partial gauge-invariance.

  17. 3D vector flow imaging

    DEFF Research Database (Denmark)

    Pihl, Michael Johannes

    The main purpose of this PhD project is to develop an ultrasonic method for 3D vector flow imaging. The motivation is to advance the field of velocity estimation in ultrasound, which plays an important role in the clinic. The velocity of blood has components in all three spatial dimensions, yet...... conventional methods can estimate only the axial component. Several approaches for 3D vector velocity estimation have been suggested, but none of these methods have so far produced convincing in vivo results nor have they been adopted by commercial manufacturers. The basis for this project is the Transverse...... on the TO fields are suggested. They can be used to optimize the TO method. In the third part, a TO method for 3D vector velocity estimation is proposed. It employs a 2D phased array transducer and decouples the velocity estimation into three velocity components, which are estimated simultaneously based on 5...

  18. 3-D Vector Flow Imaging

    DEFF Research Database (Denmark)

    Holbek, Simon

    studies and in vivo. Phantom measurements are compared with their corresponding reference value, whereas the in vivo measurement is validated against the current golden standard for non-invasive blood velocity estimates, based on magnetic resonance imaging (MRI). The study concludes, that a high precision......, if this significant reduction in the element count can still provide precise and robust 3-D vector flow estimates in a plane. The study concludes that the RC array is capable of estimating precise 3-D vector flow both in a plane and in a volume, despite the low channel count. However, some inherent new challenges......For the last decade, the field of ultrasonic vector flow imaging has gotten an increasingly attention, as the technique offers a variety of new applications for screening and diagnostics of cardiovascular pathologies. The main purpose of this PhD project was therefore to advance the field of 3-D...

  19. Skyrmions with vector mesons revisited

    CERN Document Server

    Oh, Yongseok

    2014-01-01

    In order to develop a model that can describe both a single baryon and multi-baryon systems on the same footing, we re-investigate the Skyrme model in a chiral Lagrangian derived from the hidden local symmetry (HLS) up to $O(p^4)$ including the homogeneous Wess-Zumino terms. We use the master formulas that connect the parameters of the HLS Lagrangian and a class of holographic QCD models, which provides a controllable way to determine the low-energy constants of the Lagrangian once the pion decay constant and the vector meson mass are given. Therefore, this model allows us to study the role of vector mesons in the skyrmion structure. We find that the $\\rho$ and $\\omega$ vector mesons have different roles in the skyrmion structure and that the $\\omega$ meson has an important role in the properties of the nucleon.

  20. Quantum contextuality for rational vectors

    CERN Document Server

    Cabello, Adan

    2010-01-01

    The Kochen-Specker theorem states that noncontextual hidden variable models are inconsistent with the quantum predictions for every yes-no question on a qutrit, corresponding to every projector in three dimensions. It has been suggested [D. A. Meyer, Phys. Rev. Lett. 83, 3751 (1999)] that the inconsistency would disappear when we are restricted to projectors on unit vectors with rational components; that noncontextual hidden variables could reproduce the quantum predictions for rational vectors. Here we show that a qutrit state with rational components violates an inequality valid for noncontextual hidden-variable models [A. A. Klyachko et al., Phys. Rev. Lett. 101, 020403 (2008)] using rational projectors. This shows that the inconsistency remains even when using only rational vectors.

  1. Vector bundles on toric varieties

    CERN Document Server

    Gharib, Saman

    2011-01-01

    Following Sam Payne's work, we study the existence problem of nontrivial vector bundles on toric varieties. The first result we prove is that every complete fan admits a nontrivial conewise linear multivalued function. Such functions could potentially be the Chern classes of toric vector bundles. Then we use the results of Corti\\~nas, Haesemeyer, Walker and Weibel to show that the (non-equivariant) Grothendieck group of the toric 3-fold studied by Payne is large, so the variety has a nontrivial vector bundle. Using the same computation, we show that every toric 3-fold X either has a nontrivial line bundle, or there is a finite surjective toric morphism from Y to X, such that Y has a large Grothendieck group.

  2. Quantum contextuality for rational vectors

    Energy Technology Data Exchange (ETDEWEB)

    Cabello, Adan, E-mail: adan@us.e [Departamento de Fisica Aplicada II, Universidad de Sevilla, E-41012 Sevilla (Spain); Larsson, Jan-Ake, E-mail: jan-ake.larsson@liu.s [Institutionen foer Systemteknik, Linkoepings Universitet, SE-581 83 Linkoeping (Sweden)

    2010-12-01

    The Kochen-Specker theorem states that noncontextual hidden variable models are inconsistent with the quantum predictions for every yes-no question on a qutrit, corresponding to every projector in three dimensions. It has been suggested [D.A. Meyer, Phys. Rev. Lett. 83 (1999) 3751] that the inconsistency would disappear when restricting to projectors on unit vectors with rational components; that noncontextual hidden variables could reproduce the quantum predictions for rational vectors. Here we show that a qutrit state with rational components violates an inequality valid for noncontextual hidden-variable models [A.A. Klyachko et al., Phys. Rev. Lett. 101 (2008) 020403] using rational projectors. This shows that the inconsistency remains even when using only rational vectors.

  3. Impact of vector dispersal and host-plant fidelity on the dissemination of an emerging plant pathogen.

    Directory of Open Access Journals (Sweden)

    Jes Johannesen

    Full Text Available Dissemination of vector-transmitted pathogens depend on the survival and dispersal of the vector and the vector's ability to transmit the pathogen, while the host range of vector and pathogen determine the breath of transmission possibilities. In this study, we address how the interaction between dispersal and plant fidelities of a pathogen (stolbur phytoplasma tuf-a and its vector (Hyalesthes obsoletus: Cixiidae affect the emergence of the pathogen. Using genetic markers, we analysed the geographic origin and range expansion of both organisms in Western Europe and, specifically, whether the pathogen's dissemination in the northern range is caused by resident vectors widening their host-plant use from field bindweed to stinging nettle, and subsequent host specialisation. We found evidence for common origins of pathogen and vector south of the European Alps. Genetic patterns in vector populations show signals of secondary range expansion in Western Europe leading to dissemination of tuf-a pathogens, which might be newly acquired and of hybrid origin. Hence, the emergence of stolbur tuf-a in the northern range was explained by secondary immigration of vectors carrying stinging nettle-specialised tuf-a, not by widening the host-plant spectrum of resident vectors with pathogen transmission from field bindweed to stinging nettle nor by primary co-migration from the resident vector's historical area of origin. The introduction of tuf-a to stinging nettle in the northern range was therefore independent of vector's host-plant specialisation but the rapid pathogen dissemination depended on the vector's host shift, whereas the general dissemination elsewhere was linked to plant specialisation of the pathogen but not of the vector.

  4. Learning with Support Vector Machines

    CERN Document Server

    Campbell, Colin

    2010-01-01

    Support Vectors Machines have become a well established tool within machine learning. They work well in practice and have now been used across a wide range of applications from recognizing hand-written digits, to face identification, text categorisation, bioinformatics, and database marketing. In this book we give an introductory overview of this subject. We start with a simple Support Vector Machine for performing binary classification before considering multi-class classification and learning in the presence of noise. We show that this framework can be extended to many other scenarios such a

  5. Requirements for airborne vector gravimetry

    Science.gov (United States)

    Schwarz, K. P.; Colombo, O.; Hein, G.; Knickmeyer, E. T.

    1992-01-01

    The objective of airborne vector gravimetry is the determination of the full gravity disturbance vector along the aircraft trajectory. The paper briefly outlines the concept of this method using a combination of inertial and GPS-satellite data. The accuracy requirements for users in geodesy and solid earth geophysics, oceanography and exploration geophysics are then specified. Using these requirements, accuracy specifications for the GPS subsystem and the INS subsystem are developed. The integration of the subsystems and the problems connected with it are briefly discussed and operational methods are indicated that might reduce some of the stringent accuracy requirements.

  6. Vector Theory in Relativistic Thermodynamics

    Institute of Scientific and Technical Information of China (English)

    刘泽文

    1994-01-01

    It is pointed out that five defects occur in Planck-Einstein’s relativistic thermodynamics (P-E theory). A vector theory in relativistic thermodynamics (VTRT) is established. Defining the internal energy as a 4-vector, and supposing the entropy and the number of. particles to be invariants we have derived the transformations of all quantities, and subsequently got the Lagrangian and 4-D forms of thermodynamic laws. In order to test the new theory, several exact solutions with classical limits are given. The VTRT is free from the defects of the P-E theory.

  7. An improved yeast two-hybrid approach for detection of interacting proteins

    Institute of Scientific and Technical Information of China (English)

    Wan Bingbing; Shi Yan; Huo Keke

    2006-01-01

    Yeast two-hybrid approach is popularly used nowadays as an important technical method in the field of studying protein-protein interactions.Although yeast two-hybrid system is obviously advantageous in searching interacting proteins and setting up the network of proteins interaction.not all of proteins can use routine yeast two-hybrid method to search interacting proteins.Many important proteins,such as some nucleoprotein transcriptional factor,carry out the regular method and construct the bait-BD vector to screen the library containing AD vector.However,it usually results in failures because it contains the activate domain and can self-activate the reporter gene.In this study,we changed the research strategy,fused the bait gene(FOXA3)with the AD vector to screen the library containing BD vector,so that we constructed a two-hybrid library containing BD vector and Can bypass the interference of self-activation.And we used this two-hybrid library to screen FOXA3.a hepatocyte nuclear factor,and found out an interacting protein:complement component C3.

  8. The hydrogen hybrid option

    Energy Technology Data Exchange (ETDEWEB)

    Smith, J.R.

    1993-10-15

    The energy efficiency of various piston engine options for series hybrid automobiles are compared with conventional, battery powered electric, and proton exchange membrane (PEM) fuel cell hybrid automobiles. Gasoline, compressed natural gas (CNG), and hydrogen are considered for these hybrids. The engine and fuel comparisons are done on a basis of equal vehicle weight, drag, and rolling resistance. The relative emissions of these various fueled vehicle options are also presented. It is concluded that a highly optimized, hydrogen fueled, piston engine, series electric hybrid automobile will have efficiency comparable to a similar fuel cell hybrid automobile and will have fewer total emissions than the battery powered vehicle, even without a catalyst.

  9. Hybridization and extinction.

    Science.gov (United States)

    Todesco, Marco; Pascual, Mariana A; Owens, Gregory L; Ostevik, Katherine L; Moyers, Brook T; Hübner, Sariel; Heredia, Sylvia M; Hahn, Min A; Caseys, Celine; Bock, Dan G; Rieseberg, Loren H

    2016-08-01

    Hybridization may drive rare taxa to extinction through genetic swamping, where the rare form is replaced by hybrids, or by demographic swamping, where population growth rates are reduced due to the wasteful production of maladaptive hybrids. Conversely, hybridization may rescue the viability of small, inbred populations. Understanding the factors that contribute to destructive versus constructive outcomes of hybridization is key to managing conservation concerns. Here, we survey the literature for studies of hybridization and extinction to identify the ecological, evolutionary, and genetic factors that critically affect extinction risk through hybridization. We find that while extinction risk is highly situation dependent, genetic swamping is much more frequent than demographic swamping. In addition, human involvement is associated with increased risk and high reproductive isolation with reduced risk. Although climate change is predicted to increase the risk of hybridization-induced extinction, we find little empirical support for this prediction. Similarly, theoretical and experimental studies imply that genetic rescue through hybridization may be equally or more probable than demographic swamping, but our literature survey failed to support this claim. We conclude that halting the introduction of hybridization-prone exotics and restoring mature and diverse habitats that are resistant to hybrid establishment should be management priorities.

  10. Population structure of a vector-borne plant parasite.

    Science.gov (United States)

    Yule, Kelsey M; Koop, Jennifer A H; Alexandre, Nicolas M; Johnston, Lauren R; Whiteman, Noah K

    2016-07-01

    Parasites are among the most diverse groups of life on Earth, yet complex natural histories often preclude studies of their speciation processes. The biology of parasitic plants facilitates in situ collection of data on both genetic structure and the mechanisms responsible for that structure. Here, we studied the role of mating, dispersal and establishment in host race formation of a parasitic plant. We investigated the population genetics of a vector-borne desert mistletoe (Phoradendron californicum) across two legume host tree species (Senegalia greggii and Prosopis velutina) in the Sonoran desert using microsatellites. Consistent with host race formation, we found strong host-associated genetic structure in sympatry, little genetic variation due to geographic site and weak isolation by distance. We hypothesize that genetic differentiation results from differences in the timing of mistletoe flowering by host species, as we found initial flowering date of individual mistletoes correlated with genetic ancestry. Hybrids with intermediate ancestry were detected genetically. Individuals likely resulting from recent, successful establishment events following dispersal between the host species were detected at frequencies similar to hybrids between host races. Therefore, barriers to gene flow between the host races may have been stronger at mating than at dispersal. We also found higher inbreeding and within-host individual relatedness values for mistletoes on the more rare and isolated host species (S. greggii). Our study spanned spatial scales to address how interactions with both vectors and hosts influence parasitic plant structure with implications for parasite virulence evolution and speciation.

  11. Spoof Plasmon Hybridization

    CERN Document Server

    Zhang, Jingjing; Luo, Yu; Shen, Xiaopeng; Maier, Stefan A; Cui, Tie Jun

    2016-01-01

    Plasmon hybridization between closely spaced nanoparticles yields new hybrid modes not found in individual constituents, allowing for the engineering of resonance properties and field enhancement capabilities of metallic nanostructure. Experimental verifications of plasmon hybridization have been thus far mostly limited to optical frequencies, as metals cannot support surface plasmons at longer wavelengths. Here, we introduce the concept of 'spoof plasmon hybridization' in highly conductive metal structures and investigate experimentally the interaction of localized surface plasmon resonances (LSPR) in adjacent metal disks corrugated with subwavelength spiral patterns. We show that the hybridization results in the splitting of spoof plasmon modes into bonding and antibonding resonances analogous to molecular orbital rule and plasmonic hybridization in optical spectrum. These hybrid modes can be manipulated to produce enormous field enhancements (larger than 5000) by tuning the separation between disks or alte...

  12. Vector-meson dominance revisited

    Directory of Open Access Journals (Sweden)

    Terschlüsen Carla

    2012-12-01

    Full Text Available The interaction of mesons with electromagnetism is often well described by the concept of vector-meson dominance (VMD. However, there are also examples where VMD fails. A simple chiral Lagrangian for pions, rho and omega mesons is presented which can account for the respective agreement and disagreement between VMD and phenomenology in the sector of light mesons.

  13. The consequences of poor vectorization

    CERN Document Server

    CERN. Geneva

    2016-01-01

    This talk briefly discusses the vectorization problem and how it impacts scientific and engineering systems. A simple cost model of designing such system in context of different phases of software lifetime is considered. Finally a concept for scalable solution is presented.

  14. Sparse Matrix Vector Processing Formats

    NARCIS (Netherlands)

    Stathis, P.T.

    2004-01-01

    In this dissertation we have identified vector processing shortcomings related to the efficient storing and processing of sparse matrices. To alleviate existent problems we propose two storage formats denoted as Block Based Compression Storage (BBCS) format and Hierarchical Sparse Matrix (HiSM) stor

  15. Bifurcations of optimal vector fields

    NARCIS (Netherlands)

    Kiseleva, T.; Wagener, F.

    2015-01-01

    We study the structure of the solution set of a class of infinite-horizon dynamic programming problems with one-dimensional state spaces, as well as their bifurcations, as problem parameters are varied. The solutions are represented as the integral curves of a multivalued optimal vector field on sta

  16. Portfolio Analysis for Vector Calculus

    Science.gov (United States)

    Kaplan, Samuel R.

    2015-01-01

    Classic stock portfolio analysis provides an applied context for Lagrange multipliers that undergraduate students appreciate. Although modern methods of portfolio analysis are beyond the scope of vector calculus, classic methods reinforce the utility of this material. This paper discusses how to introduce classic stock portfolio analysis in a…

  17. Phlebotomine Vectors of Human Disease.

    Science.gov (United States)

    1983-12-30

    different. We refrain from naming this specimen until more material becomes available. 12. Lutzomyia olmeca bicolor Fairchild and Theodor 1971...Castillo (1958) and Arzube (1960). Lutzomyia olmeca bicolor is the suspected vector of Leishmania mexicana aristedesi among rodents and marsupials in

  18. Phase transitions in Vector Quantization

    NARCIS (Netherlands)

    Witoelar, Aree; Ghosh, Anarta; Biehl, Michael; Verleysen, Michel

    2008-01-01

    We study Winner-Takes-All and rank based Vector Quantization along the lines of the statistical physics of off-line learning. Typical behavior of the system is obtained within a model where high-dimensional training data are drawn from a mixture of Gaussians. The analysis becomes exact in the simpli

  19. Portfolio Analysis for Vector Calculus

    Science.gov (United States)

    Kaplan, Samuel R.

    2015-01-01

    Classic stock portfolio analysis provides an applied context for Lagrange multipliers that undergraduate students appreciate. Although modern methods of portfolio analysis are beyond the scope of vector calculus, classic methods reinforce the utility of this material. This paper discusses how to introduce classic stock portfolio analysis in a…

  20. SCALAR AND VECTOR IN COMPULATION

    Directory of Open Access Journals (Sweden)

    Valery F. Ochkov

    2013-01-01

    Full Text Available The article deals with two fundamental data types – scalar and vector (array, without the ability of working with them one cannot solve using computer school or university tasks in mathematics, physics, chemistry and other technical training courses. Some fundamentals of teaching computer science at school and university are covered as well. 

  1. Vector-valued fuzzy multifunctions

    Directory of Open Access Journals (Sweden)

    Ismat Beg

    2001-01-01

    Full Text Available Some of the properties of vector-valued fuzzy multifunctions are studied. The notion of sum fuzzy multifunction, convex hull fuzzy multifunction, close convex hull fuzzy multifunction, and upper demicontinuous are given, and some of the properties of these fuzzy multifunctions are investigated.

  2. Scalar Calibration of Vector Magnetometers

    DEFF Research Database (Denmark)

    Merayo, José M.G.; Brauer, Peter; Primdahl, Fritz;

    2000-01-01

    The calibration parameters of a vector magnetometer are estimated only by the use of a scalar reference magnetometer. The method presented in this paper differs from those previously reported in its linearized parametrization. This allows the determination of three offsets or signals in the absence...

  3. Biosafety features of lentiviral vectors.

    Science.gov (United States)

    Schambach, Axel; Zychlinski, Daniela; Ehrnstroem, Birgitta; Baum, Christopher

    2013-02-01

    Over the past decades, lentiviral vectors have evolved as a benchmark tool for stable gene transfer into cells with a high replicative potential. Their relatively flexible genome and ability to transduce many forms of nondividing cells, combined with the potential for cell-specific pseudotyping, provides a rich resource for numerous applications in experimental platforms and therapeutic settings. Here, we give an overview of important biosafety features of lentiviral vectors, with detailed discussion of (i) the principles of the lentiviral split-genome design used for the construction of packaging cells; (ii) the relevance of modifications introduced into the lentiviral long terminal repeat (deletion of enhancer/promoter sequences and introduction of insulators); (iii) the basic features of mRNA processing, including the Rev/Rev-responsive element (RRE) interaction and the modifications of the 3' untranslated region of lentiviral vectors with various post-transcriptional regulatory elements affecting transcriptional termination, polyadenylation, and differentiation-specific degradation of mRNA; and (iv) the characteristic integration pattern with the associated risk of transcriptional interference with cellular genes. We conclude with considerations regarding the importance of cell targeting via envelope modifications. Along this course, we address canonical biosafety issues encountered with any type of viral vector: the risks of shedding, mobilization, germline transmission, immunogenicity, and insertional mutagenesis.

  4. Vector ecology of equine piroplasmosis

    Science.gov (United States)

    Equine piroplasmosis (EP) is a disease of equidae including horses, donkeys, mules and zebras caused by either of two protozoan parasites, Theileria equi or Babesia caballi. These parasites are biologically transmitted between hosts via tick-vectors and although they have inherent differences, they ...

  5. Vector Bundles over Elliptic Fibrations

    CERN Document Server

    Friedman, R; Witten, Edward; Friedman, Robert; Morgan, John W.; Witten, Edward

    1997-01-01

    This paper gives various methods for constructing vector bundles over elliptic curves and more generally over families of elliptic curves. We construct universal families over generalized elliptic curves via spectral cover methods and also by extensions, and then give a relative version of the construction in families. We give various examples and make Chern class computations.

  6. Large N Expansion. Vector Models

    CERN Document Server

    Nissimov, E; Nissimov, Emil; Pacheva, Svetlana

    2006-01-01

    Preliminary version of a contribution to the "Quantum Field Theory. Non-Perturbative QFT" topical area of "Modern Encyclopedia of Mathematical Physics" (SELECTA), eds. Aref'eva I, and Sternheimer D, Springer (2007). Consists of two parts - "main article" (Large N Expansion. Vector Models) and a "brief article" (BPHZL Renormalization).

  7. Marine Fish Hybridization

    KAUST Repository

    He, Song

    2017-04-01

    Natural hybridization is reproduction (without artificial influence) between two or more species/populations which are distinguishable from each other by heritable characters. Natural hybridizations among marine fishes were highly underappreciated due to limited research effort; it seems that this phenomenon occurs more often than is commonly recognized. As hybridization plays an important role in biodiversity processes in the marine environment, detecting hybridization events and investigating hybridization is important to understand and protect biodiversity. The first chapter sets the framework for this disseration study. The Cohesion Species Concept was selected as the working definition of a species for this study as it can handle marine fish hybridization events. The concept does not require restrictive species boundaries. A general history and background of natural hybridization in marine fishes is reviewed during in chapter as well. Four marine fish hybridization cases were examed and documented in Chapters 2 to 5. In each case study, at least one diagnostic nuclear marker, screened from among ~14 candidate markers, was found to discriminate the putative hybridizing parent species. To further investigate genetic evidence to support the hybrid status for each hybrid offspring in each case, haploweb analysis on diagnostic markers (nuclear and/or mitochondrial) and the DAPC/PCA analysis on microsatellite data were used. By combining the genetic evidences, morphological traits, and ecological observations together, the potential reasons that triggered each hybridization events and the potential genetic/ecology effects could be discussed. In the last chapter, sequences from 82 pairs of hybridizing parents species (for which COI barcoding sequences were available either on GenBank or in our lab) were collected. By comparing the COI fragment p-distance between each hybridizing parent species, some general questions about marine fish hybridization were discussed: Is

  8. Spoken Language Identification Using Hybrid Feature Extraction Methods

    CERN Document Server

    Kumar, Pawan; Mishra, A N; Chandra, Mahesh

    2010-01-01

    This paper introduces and motivates the use of hybrid robust feature extraction technique for spoken language identification (LID) system. The speech recognizers use a parametric form of a signal to get the most important distinguishable features of speech signal for recognition task. In this paper Mel-frequency cepstral coefficients (MFCC), Perceptual linear prediction coefficients (PLP) along with two hybrid features are used for language Identification. Two hybrid features, Bark Frequency Cepstral Coefficients (BFCC) and Revised Perceptual Linear Prediction Coefficients (RPLP) were obtained from combination of MFCC and PLP. Two different classifiers, Vector Quantization (VQ) with Dynamic Time Warping (DTW) and Gaussian Mixture Model (GMM) were used for classification. The experiment shows better identification rate using hybrid feature extraction techniques compared to conventional feature extraction methods.BFCC has shown better performance than MFCC with both classifiers. RPLP along with GMM has shown be...

  9. Exact Verification of Hybrid Systems Based on Bilinear SOS Representation

    CERN Document Server

    Yang, Zhengfeng; Lin, Wang

    2012-01-01

    In this paper, we address the problem of safety verification of nonlinear hybrid systems and stability analysis of nonlinear autonomous systems. A hybrid symbolic-numeric method is presented to compute exact inequality invariants of hybrid systems and exact estimates of regions of attraction of autonomous systems efficiently. Some numerical invariants of a hybrid system or an estimate of region of attraction can be obtained by solving a bilinear SOS program via PENBMI solver or iterative method, then the modified Newton refinement and rational vector recovery techniques are applied to obtain exact polynomial invariants and estimates of regions of attraction with rational coefficients. Experiments on some benchmarks are given to illustrate the efficiency of our algorithm.

  10. Lyapunov exponents computation for hybrid neurons.

    Science.gov (United States)

    Bizzarri, Federico; Brambilla, Angelo; Gajani, Giancarlo Storti

    2013-10-01

    Lyapunov exponents are a basic and powerful tool to characterise the long-term behaviour of dynamical systems. The computation of Lyapunov exponents for continuous time dynamical systems is straightforward whenever they are ruled by vector fields that are sufficiently smooth to admit a variational model. Hybrid neurons do not belong to this wide class of systems since they are intrinsically non-smooth owing to the impact and sometimes switching model used to describe the integrate-and-fire (I&F) mechanism. In this paper we show how a variational model can be defined also for this class of neurons by resorting to saltation matrices. This extension allows the computation of Lyapunov exponent spectrum of hybrid neurons and of networks made up of them through a standard numerical approach even in the case of neurons firing synchronously.

  11. Controlling motion prediction errors in radiotherapy with relevance vector machines.

    Science.gov (United States)

    Dürichen, Robert; Wissel, Tobias; Schweikard, Achim

    2015-04-01

    Robotic radiotherapy can precisely ablate moving tumors when time latencies have been compensated. Recently, relevance vector machines (RVM), a probabilistic regression technique, outperformed six other prediction algorithms for respiratory compensation. The method has the distinct advantage that each predicted point is assumed to be drawn from a normal distribution. Second-order statistics, the predicted variance, were used to control RVM prediction error during a treatment and to construct hybrid prediction algorithms. First, the duty cycle and the precision were correlated to the variance by interrupting the treatment if the variance exceeds a threshold. Second, two hybrid algorithms based on the variance were developed, one consisting of multiple RVMs (HYB(RVM)) and the other of a combination between a wavelet-based least mean square algorithm (wLMS) and a RVM (HYB(wLMS-RVM)). The variance for different motion traces was analyzed to reveal a characteristic variance pattern which gives insight in what kind of prediction errors can be controlled by the variance. Limiting the variance by a threshold resulted in an increased precision with a decreased duty cycle. All hybrid algorithms showed an increased prediction accuracy compared to using only their individual algorithms. The best hybrid algorithm, HYB(RVM), can decrease the mean RMSE over all 304 motion traces from 0.18 mm for a linear RVM to 0.17 mm. The predicted variance was shown to be an efficient metric to control prediction errors, resulting in a more robust radiotherapy treatment. The hybrid algorithm HYB(RVM) could be translated to clinical practice. It does not require further parameters, can be completely parallelised and easily further extended.

  12. A very low bit rate video coder based on vector quantization.

    Science.gov (United States)

    Corte-Real, L; Alves, A P

    1996-01-01

    Describes a video coder based on a hybrid DPCM-vector quantization algorithm that is suited for bit rates ranging from 8-16 kb/s. The proposed approach involves segmenting difference images into variable-size and variable-shape blocks and performing segmentation and motion compensation simultaneously. The purpose of obtaining motion vectors for variable-size and variable-shape blocks is to improve the quality of motion estimation, particularly in those areas where the edges of moving objects are situated. For the larger blocks, decimation takes place in order to simplify vector quantization. For very active blocks, which are always of small dimension, a specific vector quantizer has been applied, the fuzzy classified vector quantizer (FCVQ). The coding algorithm described displays good performance in the compression of test sequences at the rates of 8 and 16 kb/s; the signal-to-noise ratios obtained are good in both cases. The complexity of the coder implementation is comparable to that of conventional hybrid coders, while the decoder is much simpler in this proposal.

  13. Vector variational inequalities and their relations with vector optimization

    Directory of Open Access Journals (Sweden)

    Surjeet Kaur Suneja

    2014-01-01

    Full Text Available In this paper, K- quasiconvex, K- pseudoconvex and other related functions have been introduced in terms of their Clarke subdifferentials, where is an arbitrary closed convex, pointed cone with nonempty interior. The (strict, weakly -pseudomonotonicity, (strict K- naturally quasimonotonicity and K- quasimonotonicity of Clarke subdifferential maps have also been defined. Further, we introduce Minty weak (MVVIP and Stampacchia weak (SVVIP vector variational inequalities over arbitrary cones. Under regularity assumption, we have proved that a weak minimum solution of vector optimization problem (VOP is a solution of (SVVIP and under the condition of K- pseudoconvexity we have obtained the converse for MVVIP (SVVIP. In the end we study the interrelations between these with the help of strict K-naturally quasimonotonicity of Clarke subdifferential map.

  14. Optimized support vector regression for drilling rate of penetration estimation

    Science.gov (United States)

    Bodaghi, Asadollah; Ansari, Hamid Reza; Gholami, Mahsa

    2015-12-01

    In the petroleum industry, drilling optimization involves the selection of operating conditions for achieving the desired depth with the minimum expenditure while requirements of personal safety, environment protection, adequate information of penetrated formations and productivity are fulfilled. Since drilling optimization is highly dependent on the rate of penetration (ROP), estimation of this parameter is of great importance during well planning. In this research, a novel approach called `optimized support vector regression' is employed for making a formulation between input variables and ROP. Algorithms used for optimizing the support vector regression are the genetic algorithm (GA) and the cuckoo search algorithm (CS). Optimization implementation improved the support vector regression performance by virtue of selecting proper values for its parameters. In order to evaluate the ability of optimization algorithms in enhancing SVR performance, their results were compared to the hybrid of pattern search and grid search (HPG) which is conventionally employed for optimizing SVR. The results demonstrated that the CS algorithm achieved further improvement on prediction accuracy of SVR compared to the GA and HPG as well. Moreover, the predictive model derived from back propagation neural network (BPNN), which is the traditional approach for estimating ROP, is selected for comparisons with CSSVR. The comparative results revealed the superiority of CSSVR. This study inferred that CSSVR is a viable option for precise estimation of ROP.

  15. Model Checking Vector Addition Systems with one zero-test

    CERN Document Server

    Bonet, Rémi; Leroux, Jérôme; Zeitoun, Marc

    2012-01-01

    We design a variation of the Karp-Miller algorithm to compute, in a forward manner, a finite representation of the cover (i.e., the downward closure of the reachability set) of a vector addition system with one zero-test. This algorithm yields decision procedures for several problems for these systems, open until now, such as place-boundedness or LTL model-checking. The proof techniques to handle the zero-test are based on two new notions of cover: the refined and the filtered cover. The refined cover is a hybrid between the reachability set and the classical cover. It inherits properties of the reachability set: equality of two refined covers is undecidable, even for usual Vector Addition Systems (with no zero-test), but the refined cover of a Vector Addition System is a recursive set. The second notion of cover, called the filtered cover, is the central tool of our algorithms. It inherits properties of the classical cover, and in particular, one can effectively compute a finite representation of this set, e...

  16. Using vector divisions in solving linear complementarity problem

    CERN Document Server

    Elfoutayeni, Youssef

    2010-01-01

    The linear complementarity problem is to find vector $z$ in $\\mathrm{IR}^{n}$ satisfying $z^{T}(Mz+q)=0$, $Mz+q\\geqslant0,$ $z\\geqslant0$, where $M$ as a matrix and $q$ as a vector, are given data; this problem becomes in present the subject of much important research because it arises in many areas and it includes important fields, we cite for example the linear and nonlinear programming, the convex quadratic programming and the variational inequalities problems, ... It is known that the linear complementarity problem is completely equivalent to solving nonlinear equation $F(x)=0$ with $F$ is a function from $\\mathrm{IR}^{n}$ into itself defined by $F(x)=(M+I)x+(M-I)|x|+q$. In this paper we propose a globally convergent hybrid algorithm for solving this equation; this method is based on an algorithm given by Shi \\cite{Y. Shi}, he uses vector divisions with the secant method; but for using this method we must have a function continuous with partial derivatives on an open set of $\\mathrm{IR}^{n}$; so we built ...

  17. Support Vector Regression Algorithms in the Forecasting of Daily Maximums of Tropospheric Ozone Concentration in Madrid

    Science.gov (United States)

    Ortiz-García, E. G.; Salcedo-Sanz, S.; Pérez-Bellido, A. M.; Gascón-Moreno, J.; Portilla-Figueras, A.

    In this paper we present the application of a support vector regression algorithm to a real problem of maximum daily tropospheric ozone forecast. The support vector regression approach proposed is hybridized with an heuristic for optimal selection of hyper-parameters. The prediction of maximum daily ozone is carried out in all the station of the air quality monitoring network of Madrid. In the paper we analyze how the ozone prediction depends on meteorological variables such as solar radiation and temperature, and also we perform a comparison against the results obtained using a multi-layer perceptron neural network in the same prediction problem.

  18. Vector-Boson Fusion and Vector-Boson Scattering

    CERN Document Server

    Rauch, Michael

    2016-01-01

    Vector-boson fusion and vector-boson scattering are an important class of processes for the Large Hadron Collider at CERN. It is characterized by two high-energetic jets in the forward regions of the detector and reduced jet activity in the central region. The higher center-of-mass energy during the current and subsequent runs strongly boosts the sensitivity in these processes and allows to test the predictions of the Standard Model to a high precision. In this review, we first present the main phenomenological features of vector-boson fusion and scattering processes. Then we discuss the effects of higher-order corrections, which are available at NLO QCD for all processes and up to N3LO QCD and NLO electro-weak for VBF-H production. An additional refinement is the addition of parton-shower effects, where recently a lot of progress has been made. The appearance of triple and quartic gauge vertices in the production processes enables us to probe anomalous gauge couplings. We introduce and compare the different ...

  19. Symbolic Vector Analysis in Plasma Physics

    Energy Technology Data Exchange (ETDEWEB)

    Qin, H.; Tang, W.M.; Rewoldt, G.

    1997-10-09

    Many problems in plasma physics involve substantial amounts of analytical vector calculation. The complexity usually originates from both the vector operations themselves and the choice of underlying coordinate system. A computer algebra package for symbolic vector analysis in general coordinate systems, General Vector Analysis (GVA), is developed using Mathematica. The modern viewpoint for 3D vector calculus, differential forms on 3-manifolds, is adopted to unify and systematize the vector calculus operations in general coordinate systems. This package will benefit physicists and applied mathematicians in their research where complicated vector analysis is required. It will not only save a huge amount of human brain-power and dramatically improve accuracy, but this package will also be an intelligent tool to assist researchers in finding the right approaches to their problems. Several applications of this symbolic vector analysis package to plasma physics are also given.

  20. Symbolic Vector Analysis in Plasma Physics

    Energy Technology Data Exchange (ETDEWEB)

    Qin, H.; Rewoldt, G.; Tang, W.M.

    1997-10-01

    Many problems in plasma physics involve substantial amounts of analytical vector calculation. The complexity usually originates from both the vector operations themselves and the choice of underlying coordinate system. A computer algebra package for symbolic vector analysis in general coordinate systems, GeneralVectorAnalysis (GVA), is developed using Mathematica. The modern viewpoint for 3D vector calculus, differential forms on 3-manifolds, is adopted to unify and systematize the vector calculus operations in general coordinate systems. This package will benefit physicists and applied mathematicians in their research where complicated vector analysis is required. It will not only save a huge amount of human brain-power and dramatically improve accuracy, but this package will also be an intelligent tool to assist researchers in finding the right approaches to their problems. Several applications of this symbolic vector analysis package to plasma physics are also given.

  1. On third order integrable vector Hamiltonian equations

    Science.gov (United States)

    Meshkov, A. G.; Sokolov, V. V.

    2017-03-01

    A complete list of third order vector Hamiltonian equations with the Hamiltonian operator Dx having an infinite series of higher conservation laws is presented. A new vector integrable equation on the sphere is found.

  2. SYSTEM OF GENERALIZED VECTOR VARIATIONAL INEQUALITIES

    Institute of Scientific and Technical Information of China (English)

    Fang Yaping; Huang Nanjing

    2005-01-01

    In this paper, the authors introduce and study system of generalized vector variational inequalities. Under suitable conditions, the existence of solutions for system of generalized vector variational inequalities is presented by Kakutani-Fan-Glicksberg fixed point theorem.

  3. Henkin and Hybrid Logic

    DEFF Research Database (Denmark)

    Blackburn, Patrick Rowan; Huertas, Antonia; Manzano, Maria;

    2014-01-01

    Leon Henkin was not a modal logician, but there is a branch of modal logic that has been deeply influenced by his work. That branch is hybrid logic, a family of logics that extend orthodox modal logic with special proposition symbols (called nominals) that name worlds. This paper explains why...... Henkin’s techniques are so important in hybrid logic. We do so by proving a completeness result for a hybrid type theory called HTT, probably the strongest hybrid logic that has yet been explored. Our completeness result builds on earlier work with a system called BHTT, or basic hybrid type theory...... is due to the first-order perspective, which lies at the heart of Henin’s best known work and hybrid logic....

  4. BSA Hybrid Synthesized Polymer

    Institute of Scientific and Technical Information of China (English)

    Zong Bin LIU; Xiao Pei DENG; Chang Sheng ZHAO

    2006-01-01

    Bovine serum albumin (BSA), a naturally occurring biopolymer, was regarded as a polymeric material to graft to an acrylic acid (AA)-N-vinyl pyrrolidone (NVP) copolymer to form a biomacromolecular hybrid polymer. The hybrid polymer can be blended with polyethersulfone (PES) to increase the hydrophilicity of the PES membrane, which suggested that the hybrid polymer might have a wide application in the modification of biomaterials.

  5. Hybrid Action Systems

    DEFF Research Database (Denmark)

    Ronkko, Mauno; Ravn, Anders P.

    1997-01-01

    a differential action, which allows differential equations as primitive actions. The extension allows us to model hybrid systems with both continuous and discrete behaviour. The main result of this paper is an extension of such a hybrid action system with parallel composition. The extension does not change...... the original meaning of the parallel composition, and therefore also the ordinary action systems can be composed in parallel with the hybrid action systems....

  6. HYBRID VEHICLE CONTROL SYSTEM

    Directory of Open Access Journals (Sweden)

    V. Dvadnenko

    2016-06-01

    Full Text Available The hybrid vehicle control system includes a start–stop system for an internal combustion engine. The system works in a hybrid mode and normal vehicle operation. To simplify the start–stop system, there were user new possibilities of a hybrid car, which appeared after the conversion. Results of the circuit design of the proposed system of basic blocks are analyzed.

  7. Nanoscale Organic Hybrid Electrolytes

    KAUST Repository

    Nugent, Jennifer L.

    2010-08-20

    Nanoscale organic hybrid electrolytes are composed of organic-inorganic hybrid nanostructures, each with a metal oxide or metallic nanoparticle core densely grafted with an ion-conducting polyethylene glycol corona - doped with lithium salt. These materials form novel solvent-free hybrid electrolytes that are particle-rich, soft glasses at room temperature; yet manifest high ionic conductivity and good electrochemical stability above 5V. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Hybrid radiator cooling system

    Science.gov (United States)

    France, David M.; Smith, David S.; Yu, Wenhua; Routbort, Jules L.

    2016-03-15

    A method and hybrid radiator-cooling apparatus for implementing enhanced radiator-cooling are provided. The hybrid radiator-cooling apparatus includes an air-side finned surface for air cooling; an elongated vertically extending surface extending outwardly from the air-side finned surface on a downstream air-side of the hybrid radiator; and a water supply for selectively providing evaporative cooling with water flow by gravity on the elongated vertically extending surface.

  9. NEVILLE-TYPE VECTOR VALUED RATIONAL INTERPOLANTS

    Institute of Scientific and Technical Information of China (English)

    陈之兵; 顾传青; 徐晨

    2004-01-01

    A new kind of vector valued rational interpolants is established by means of Samelson inverse, with scalar numerator and vector valued denominator. It is essen tially different from that of Graves-Morris(1983), where the interpolants are constructed by Thiele-type continued fractions with vector valued numerator and scalar denominator. The new approach is more suitable to calculate the value of a vector valued function for a given point. And an error formula is also given and proven.

  10. Vectors and translations in mathematics and physics

    OpenAIRE

    Dorier, Jean-Luc

    2016-01-01

    In mathematics, students learn about vectors and translation, in physics they model forces, speed, acceleration, etc. with vectors and study movements of translation. Do they make the connection between these concepts introduced in different disciplines or do they put things in separate boxes? In this paper we will start with some partial considerations on the history of vectors and we will give some references. Then we will show some examples of naïve illustrations of vectors from physics in...

  11. Diffractive Leptoproduction of Vector Mesons in QCD

    OpenAIRE

    Brodsky, Stanley J.; Frankfurt, L.; Gunion, J. F.; Mueller, A.H.; Strikman, M.

    1994-01-01

    We demonstrate that the distinctive features of the forward differential cross section of diffractive leptoproduction of a vector meson can be legitimately calculated in perturbative QCD in terms of the light-cone $q \\bar q$ wave function of the vector meson and the gluon distribution of the target. In particular, we calculate the $Q^2$ and nuclear dependence of the diffractive leptoproduction of vector mesons and estimate the cross section. The production of longitudinally polarized vector m...

  12. Medium Modification of Vector Mesons

    Energy Technology Data Exchange (ETDEWEB)

    Chaden Djalali, Michael Paolone, Dennis Weygand, Michael H. Wood, Rakhsha Nasseripour

    2011-03-01

    The theory of the strong interaction, Quantum Chromodynamics (QCD), has been remarkably successful in describing high-energy and short-distance-scale experiments involving quarks and gluons. However, applying QCD to low energy and large-distance scale experiments has been a major challenge. Various QCD-inspired models predict a partial restoration of chiral symmetry in nuclear matter with modifications of the properties of hadrons from their free-space values. Measurable changes such as a shift in mass and/or a change of width are predicted at normal nuclear density. Photoproduction of vector mesons off nuclei have been performed at different laboratories. The properties of the ρ, ω and φ mesons are investigated either directly by measuring their mass spectra or indirectly through transparency ratios. The latest results regarding medium modifications of the vector mesons in the nuclear medium will be discussed.

  13. Lentiviral vectors in cancer immunotherapy.

    Science.gov (United States)

    Oldham, Robyn Aa; Berinstein, Elliot M; Medin, Jeffrey A

    2015-01-01

    Basic science advances in cancer immunotherapy have resulted in various treatments that have recently shown success in the clinic. Many of these therapies require the insertion of genes into cells to directly kill them or to redirect the host's cells to induce potent immune responses. Other analogous therapies work by modifying effector cells for improved targeting and enhanced killing of tumor cells. Initial studies done using γ-retroviruses were promising, but safety concerns centered on the potential for insertional mutagenesis have highlighted the desire to develop other options for gene delivery. Lentiviral vectors (LVs) have been identified as potentially more effective and safer alternative delivery vehicles. LVs are now in use in clinical trials for many different types of inherited and acquired disorders, including cancer. This review will discuss current knowledge of LVs and the applications of this viral vector-based delivery vehicle to cancer immunotherapy.

  14. Clinical applications of power vectors.

    Science.gov (United States)

    Miller, Joseph M

    2009-06-01

    The study of infant vision is closely coupled to the study of the refraction, change in refraction over time, and the effect of spectacle correction on visual development. Frequently, reports are limited to descriptions of spherical equivalent or cylinder power without regard to axis, as data are frequently collected in the clinical format of sphere, cylinder, and axis (S, C, A). Conversion from clinical notation to a power vector representation of refraction allows unambiguous description of how refractions change over time and differ between repeated measurements. This article presents a series of examples of Microsoft Excel spreadsheet formulas that make the conversion from clinical notation to power vector format, and provides examples of useful applications of these methods.

  15. Gene targeting with retroviral vectors

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, J.; Bernstein, A. (Toronto Univ., ON (Canada))

    1989-04-01

    The authors have designed and constructed integration-defective retroviral vectors to explore their potential for gene targeting in mammalian cells. Two nonoverlapping deletion mutants of the bacterial neomycin resistance (neo) gene were used to detect homologous recombination events between viral and chromosomal sequences. Stable neo gene correction events were selected at a frequency of approximately 1 G418/sup r/ cell per 3 x 10/sup 6/ infected cells. Analysis of the functional neo gene in independent targeted cell clones indicated that unintegrated retroviral linear DNA recombined with the target by gene conversion for variable distances into regions of nonhomology. In addition, transient neo gene correction events which were associated with the complete loss of the chromosomal target sequences were observed. These results demonstrated that retroviral vectors can recombine with homologous chromosomal sequences in rodent and human cells.

  16. ELVIS - ELectromagnetic Vector Information Sensor

    CERN Document Server

    Bergman, J E S; Thidé, B; Ananthakrishnan, S; Wahlund, J E; Karlsson, R L; Puccio, W; Carozzi, T D; Kale, P

    2005-01-01

    The ELVIS instrument was recently proposed by the authors for the Indian Chandrayaan-1 mission to the Moon and is presently under consideration by the Indian Space Research Organisation (ISRO). The scientific objective of ELVIS is to explore the electromagnetic environment of the moon. ELVIS samples the full three-dimensional (3D) electric field vector, E(x,t), up to 18 MHz, with selective Nyqvist frequency bandwidths down to 5 kHz, and one component of the magnetic field vector, B(x,t), from a few Hz up to 100 kHz.As a transient detector, ELVIS is capable of detecting pulses with a minimum pulse width of 5 ns. The instrument comprises three orthogonal electric dipole antennas, one magnetic search coil antenna and a four-channel digital sampling system, utilising flexible digital down conversion and filtering together with state-of-the-art onboard digital signal processing.

  17. Hybrid Unifying Variable Supernetwork Model

    Institute of Scientific and Technical Information of China (English)

    LIU; Qiang; FANG; Jin-qing; LI; Yong

    2015-01-01

    In order to compare new phenomenon of topology change,evolution,hybrid ratio and network characteristics of unified hybrid network theoretical model with unified hybrid supernetwork model,this paper constructed unified hybrid variable supernetwork model(HUVSM).The first layer introduces a hybrid ratio dr,the

  18. Large Unifying Hybrid Supernetwork Model

    Institute of Scientific and Technical Information of China (English)

    LIU; Qiang; FANG; Jin-qing; LI; Yong

    2015-01-01

    For depicting multi-hybrid process,large unifying hybrid network model(so called LUHNM)has two sub-hybrid ratios except dr.They are deterministic hybrid ratio(so called fd)and random hybrid ratio(so called gr),respectively.

  19. GAPS IN SUPPORT VECTOR OPTIMIZATION

    Energy Technology Data Exchange (ETDEWEB)

    STEINWART, INGO [Los Alamos National Laboratory; HUSH, DON [Los Alamos National Laboratory; SCOVEL, CLINT [Los Alamos National Laboratory; LIST, NICOLAS [Los Alamos National Laboratory

    2007-01-29

    We show that the stopping criteria used in many support vector machine (SVM) algorithms working on the dual can be interpreted as primal optimality bounds which in turn are known to be important for the statistical analysis of SVMs. To this end we revisit the duality theory underlying the derivation of the dual and show that in many interesting cases primal optimality bounds are the same as known dual optimality bounds.

  20. Ultrasonic Dynamic Vector Stress Sensor

    Science.gov (United States)

    Heyman, Joseph S.; Froggatt, Mark

    1992-01-01

    Stress inferred from measurements in specimens rather than in bonded gauges. Ultrasonic dynamic vector stress sensor (UDVSS) measures changes in dynamic directional stress occurring in material or structure at location touched by device when material or structure put under cyclic load. Includes phase-locked loop, synchronous amplifier, and contact probe. Useful among manufacturers of aerospace and automotive structures for stress testing and evaluation of designs.

  1. A ocean bottom vector magnetometer

    Science.gov (United States)

    Wang, Xiaomei; Teng, Yuntian; Wang, Chen; Ma, Jiemei

    2017-04-01

    The new development instrument with a compact spherical coil system and Overhauser magnetometer for measuring the total strength of the magnetic field and the vectors of strength, Delta inclination - Delta declination, meanwhile we also use a triaxial fluxgate instrument of the traditional instrument for geomagnetic vector filed measurement. The advantages of this method are be calibrated by each other and get good performances with automatic operation, good stability and high resolution. Firstly, a brief description of the instrument measurement principles and the key technologies are given. The instrument used a spherical coil system with 34 coils to product the homogeneous volume inside the coils which is large enough to accommodate the sensor of Overhauser total field sensor; the rest of the footlocker-sized ocean-bottom vector magnetometer consists of equipment to run the sensors and records its data (batteries and a data logger), weight to sink it to the sea floor, a remote-controlled acoustic release and flotation to bring the instrument back to the surface. Finally, the accuracy of the instrument was tested in the Geomagnetic station, and the measurement accuracies of total strength and components were better than 0.2nT and 1nT respectively. The figure 1 shows the development instrument structure. it includes six thick glass spheres which protect the sensor, data logger and batteries from the pressures of the deep sea, meanwhile they also provide recycling positive buoyancy; To cushion the glass, the spheres then go inside yellow plastic "hardhats". The triaxial fluxgate is inside No.1 glass spheres, data logger and batteries are inside No.2 glass spheres, the new vector sensor is inside No.3 glass spheres, acoustic communication unit is inside No.4 glass spheres, No.5 and No.6 glass spheres are empty which only provide recycling positive buoyancy. The figure 2 shows the development instrument Physical photo.

  2. Biological rhythms and vector insects

    Directory of Open Access Journals (Sweden)

    Mirian David Marques

    2013-01-01

    Full Text Available The adjustment of all species, animals and plants, to the Earth’s cyclic environments is ensured by their temporal organisation. The relationships between parasites, vectors and hosts rely greatly upon the synchronisation of their biological rhythms, especially circadian rhythms. In this short note, parasitic infections by Protozoa and by microfilariae have been chosen as examples of the dependence of successful transmission mechanisms on temporal components.

  3. Mathematical Modeling of Hybrid Electrical Engineering Systems

    Directory of Open Access Journals (Sweden)

    A. A. Lobaty

    2016-01-01

    Full Text Available A large class of systems that have found application in various industries and households, electrified transportation facilities and energy sector has been classified as electrical engineering systems. Their characteristic feature is a combination of continuous and discontinuous modes of operation, which is reflected in the appearance of a relatively new term “hybrid systems”. A wide class of hybrid systems is pulsed DC converters operating in a pulse width modulation, which are non-linear systems with variable structure. Using various methods for linearization it is possible to obtain linear mathematical models that rather accurately simulate behavior of such systems. However, the presence in the mathematical models of exponential nonlinearities creates considerable difficulties in the implementation of digital hardware. The solution can be found while using an approximation of exponential functions by polynomials of the first order, that, however, violates the rigor accordance of the analytical model with characteristics of a real object. There are two practical approaches to synthesize algorithms for control of hybrid systems. The first approach is based on the representation of the whole system by a discrete model which is described by difference equations that makes it possible to synthesize discrete algorithms. The second approach is based on description of the system by differential equations. The equations describe synthesis of continuous algorithms and their further implementation in a digital computer included in the control loop system. The paper considers modeling of a hybrid electrical engineering system using differential equations. Neglecting the pulse duration, it has been proposed to describe behavior of vector components in phase coordinates of the hybrid system by stochastic differential equations containing generally non-linear differentiable random functions. A stochastic vector-matrix equation describing dynamics of the

  4. Hybrid Rocket Technology

    National Research Council Canada - National Science Library

    Sankaran Venugopal; K K Rajesh; V Ramanujachari

    2011-01-01

    With their unique operational characteristics, hybrid rockets can potentially provide safer, lower-cost avenues for spacecraft and missiles than the current solid propellant and liquid propellant systems...

  5. Hybrid FOSS Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Armstrong researchers are continuing their efforts to further develop FOSS technologies. A hybrid FOSS technique (HyFOSS) employs conventional continuous grating...

  6. Vector Fields and Flows on Differentiable Stacks

    DEFF Research Database (Denmark)

    A. Hepworth, Richard

    2009-01-01

    This paper introduces the notions of vector field and flow on a general differentiable stack. Our main theorem states that the flow of a vector field on a compact proper differentiable stack exists and is unique up to a uniquely determined 2-cell. This extends the usual result on the existence...... of vector fields....

  7. Project Physics Programmed Instruction, Vectors 3.

    Science.gov (United States)

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    This is the third of a series of three programmed instruction booklets on vectors developed by Harvard Project Physics. Separating vectors into components and obtaining a vector from its components are the topics covered. For other booklets in this series, see SE 015 549 and SE 015 550. (DT)

  8. Vector and tensor analysis with applications

    CERN Document Server

    Borisenko, A I; Silverman, Richard A

    1979-01-01

    Concise and readable, this text ranges from definition of vectors and discussion of algebraic operations on vectors to the concept of tensor and algebraic operations on tensors. It also includes a systematic study of the differential and integral calculus of vector and tensor functions of space and time. Worked-out problems and solutions. 1968 edition.

  9. Some Remarks on a Generalized Vector Product

    CERN Document Server

    Acosta-Humánez, Primitivo B; Núñez, Reinaldo

    2011-01-01

    In this paper we use a generalized vector product to construct an exterior form $\\wedge :(\\mathbb{R}^{n}) ^{k}\\to \\mathbb{R}^{\\binom{n}{k}}$, where $\\binom{n}{k}=\\frac{n!}{(n-k)!k!}$, $k\\leq n$. Finally, for $n=k-1$ we introduce the reversing operation to study this generalized vector product over palindromic and antipalindromic vectors.

  10. From hybrid swarms to swarms of hybrids

    Science.gov (United States)

    Stohlgren, Thomas J.; Szalanski, Allen L; Gaskin, John F.; Young, Nicholas E.; West, Amanda; Jarnevich, Catherine S.; Tripodi, Amber

    2015-01-01

    Science has shown that the introgression or hybridization of modern humans (Homo sapiens) with Neanderthals up to 40,000 YBP may have led to the swarm of modern humans on earth. However, there is little doubt that modern trade and transportation in support of the humans has continued to introduce additional species, genotypes, and hybrids to every country on the globe. We assessed the utility of species distributions modeling of genotypes to assess the risk of current and future invaders. We evaluated 93 locations of the genus Tamarix for which genetic data were available. Maxent models of habitat suitability showed that the hybrid, T. ramosissima x T. chinensis, was slightly greater than the parent taxa (AUCs > 0.83). General linear models of Africanized honey bees, a hybrid cross of Tanzanian Apis mellifera scutellata and a variety of European honey bee including A. m. ligustica, showed that the Africanized bees (AUC = 0.81) may be displacing European honey bees (AUC > 0.76) over large areas of the southwestern U.S. More important, Maxent modeling of sub-populations (A1 and A26 mitotypes based on mDNA) could be accurately modeled (AUC > 0.9), and they responded differently to environmental drivers. This suggests that rapid evolutionary change may be underway in the Africanized bees, allowing the bees to spread into new areas and extending their total range. Protecting native species and ecosystems may benefit from risk maps of harmful invasive species, hybrids, and genotypes.

  11. On the Distribution of Norm of Vector Projection and Rejection of Two Complex Normal Random Vectors

    Directory of Open Access Journals (Sweden)

    Mehdi Maleki

    2015-01-01

    Full Text Available Vector projection and vector rejection are highly common and useful operations in mathematics, information theory, and signal processing. In this paper, we find the distribution of the norm of projection and rejection vectors when the original vectors are standard complex normally distributed.

  12. Vectors and Rotations in 3-Dimensions: Vector Algebra for the C++ Programmer

    Science.gov (United States)

    2016-12-01

    ARL-TR-7894•DEC 2016 US Army Research Laboratory Vectors and Rotations in 3-Dimensions:Vector Algebra for the C++ Programmer by Richard Saucier...Army Research Laboratory Vectors and Rotations in 3-Dimensions:Vector Algebra for the C++ Programmer by Richard Saucier Survivability/Lethality...

  13. Hybrid model based on Genetic Algorithms and SVM applied to variable selection within fruit juice classification.

    Science.gov (United States)

    Fernandez-Lozano, C; Canto, C; Gestal, M; Andrade-Garda, J M; Rabuñal, J R; Dorado, J; Pazos, A

    2013-01-01

    Given the background of the use of Neural Networks in problems of apple juice classification, this paper aim at implementing a newly developed method in the field of machine learning: the Support Vector Machines (SVM). Therefore, a hybrid model that combines genetic algorithms and support vector machines is suggested in such a way that, when using SVM as a fitness function of the Genetic Algorithm (GA), the most representative variables for a specific classification problem can be selected.

  14. Problems and worked solutions in vector analysis

    CERN Document Server

    Shorter, LR

    2014-01-01

    ""A handy book like this,"" noted The Mathematical Gazette, ""will fill a great want."" Devoted to fully worked out examples, this unique text constitutes a self-contained introductory course in vector analysis for undergraduate and graduate students of applied mathematics.Opening chapters define vector addition and subtraction, show how to resolve and determine the direction of two or more vectors, and explain systems of coordinates, vector equations of a plane and straight line, relative velocity and acceleration, and infinitely small vectors. The following chapters deal with scalar and vect

  15. pORE: a modular binary vector series suited for both monocot and dicot plant transformation.

    Science.gov (United States)

    Coutu, Catherine; Brandle, James; Brown, Dan; Brown, Kirk; Miki, Brian; Simmonds, John; Hegedus, Dwayne D

    2007-12-01

    We present a series of 14 binary vectors suitable for Agrobacterium-mediated transformation of dicotyledonous plants and adaptable for biolistic transformation of monocotyledonous plants. The vector size has been minimized by eliminating all non-essential elements from the vector backbone and T-DNA regions while maintaining the ability to replicate independently. The smallest of the vector series is 6.3 kb and possesses an extensive multiple cloning site with 21 unique restriction endonuclease sites that are compatible with common cloning, protein expression, yeast two-hybrid and other binary vectors. The T-DNA region was engineered using a synthetic designer oligonucleotide resulting in an entirely modular system whereby any vector element can be independently exchanged. The high copy number ColE1 origin of replication has been included to enhance plasmid yield in Escherichia coli. FRT recombination sites flank the selectable marker cassette regions and allow for in planta excision by FLP recombinase. The pORE series consists of three basic types; an 'open' set for general plant transformation, a 'reporter' set for promoter analysis and an 'expression' set for constitutive expression of transgenes. The sets comprise various combinations of promoters (P (HPL), P (ENTCUP2) and P (TAPADH)), selectable markers (nptII and pat) and reporter genes (gusA and smgfp).

  16. Cardiac hybrid imaging

    Energy Technology Data Exchange (ETDEWEB)

    Gaemperli, Oliver [University Hospital Zurich, Cardiac Imaging, Zurich (Switzerland); University Hospital Zurich, Nuclear Cardiology, Cardiovascular Center, Zurich (Switzerland); Kaufmann, Philipp A. [University Hospital Zurich, Cardiac Imaging, Zurich (Switzerland); Alkadhi, Hatem [University Hospital Zurich, Institute of Diagnostic and Interventional Radiology, Zurich (Switzerland)

    2014-05-15

    Hybrid cardiac single photon emission computed tomography (SPECT)/CT imaging allows combined assessment of anatomical and functional aspects of cardiac disease. In coronary artery disease (CAD), hybrid SPECT/CT imaging allows detection of coronary artery stenosis and myocardial perfusion abnormalities. The clinical value of hybrid imaging has been documented in several subsets of patients. In selected groups of patients, hybrid imaging improves the diagnostic accuracy to detect CAD compared to the single imaging techniques. Additionally, this approach facilitates functional interrogation of coronary stenoses and guidance with regard to revascularization procedures. Moreover, the anatomical information obtained from CT coronary angiography or coronary artery calcium scores (CACS) adds prognostic information over perfusion data from SPECT. The use of cardiac hybrid imaging has been favoured by the dissemination of dedicated hybrid systems and the release of dedicated image fusion software, which allow simple patient throughput for hybrid SPECT/CT studies. Further technological improvements such as more efficient detector technology to allow for low-radiation protocols, ultra-fast image acquisition and improved low-noise image reconstruction algorithms will be instrumental to further promote hybrid SPECT/CT in research and clinical practice. (orig.)

  17. Hybrid intelligent engineering systems

    CERN Document Server

    Jain, L C; Adelaide, Australia University of

    1997-01-01

    This book on hybrid intelligent engineering systems is unique, in the sense that it presents the integration of expert systems, neural networks, fuzzy systems, genetic algorithms, and chaos engineering. It shows that these new techniques enhance the capabilities of one another. A number of hybrid systems for solving engineering problems are presented.

  18. A Hybrid Imagination

    DEFF Research Database (Denmark)

    Jamison, Andrew; Christensen, Steen Hyldgaard; Botin, Lars

    contexts, or sites, for mixing scientific knowledge and technical skills from different fields and social domains into new combinations, thus fostering what the authors term a “hybrid imagination”. Such a hybrid imagination is especially important today, as a way to counter the competitive and commercial...

  19. Hybrid trajectory spaces

    NARCIS (Netherlands)

    Collins, P.J.

    2005-01-01

    In this paper, we present a general framework for describing and studying hybrid systems. We represent the trajectories of the system as functions on a hybrid time domain, and the system itself by its trajectory space, which is the set of all possible trajectories. The trajectory space is given a na

  20. Editorial: Hybrid Systems

    DEFF Research Database (Denmark)

    Olderog, Ernst-Rüdiger; Ravn, Anders Peter

    2007-01-01

    An introduction to three papers in a special issue on Hybrid Systems. These paper were first presented at an IFIP WG 2.2 meeting in Skagen 2005.......An introduction to three papers in a special issue on Hybrid Systems. These paper were first presented at an IFIP WG 2.2 meeting in Skagen 2005....

  1. Hybrid Coding of Image Sequences by Using Wavelet Transform

    Directory of Open Access Journals (Sweden)

    M. Surin

    2000-04-01

    Full Text Available In this paper, a new method of hybrid coding of image sequences byusing wavelet transform is proposed. The basic MPEG scheme with DCT hasbeen modificated in sense of replacement DCT by wavelet transform. Inthe proposed method, the motion estimation and compensation are usedfor motion vectors calculation and different frame between currentframe and compensated frame is coded by using wavelet transform. Someexperimental results of image sequences coding by using a new methodare presented.

  2. DBSC-Based Grayscale Line Image Vectorization

    Institute of Scientific and Technical Information of China (English)

    Konstantin Melikhov; Feng Tian; Jie Qiu; Quan Chen; Hock Soon Seah

    2006-01-01

    Vector graphics plays an important role in computer animation and imaging technologies. However present techniques and tools cannot fully replace traditional pencil and paper. Additionally, vector representation of an image is not always available. There is not yet a good solution for vectorizing a picture drawn on a paper. This work attempts to solve the problem of vectorizing grayscale line drawings. The solution proposed uses Disk B-Spline curves to represent strokes of an image in vector form. The algorithm builds a vector representation from a grayscale raster image, which can be a scanned picture for instance. The proposed method uses a Gaussian sliding window to calculate skeleton and perceptive width of a stroke. As a result of vectorization, the given image is represented by a set of Disk B-Spline curves.

  3. Transversals of Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    , an important step was proving that the transversals possessed a certain characteristic. Understanding transversals might be the key to proving other polynomial vector fields are generic, and they are important in understanding bifurcations of polynomial vector fields in general. We consider two important......Vector fields in the complex plane are defined by assigning the vector determined by the value P(z) to each point z in the complex plane, where P is a polynomial of one complex variable. We consider special families of so-called rotated vector fields that are determined by a polynomial multiplied...... a concrete polynomial, it seems to take quite a bit of work to prove that it is generic, i.e. structurally stable. This has been done for a special class of degree d polynomial vector fields having simple equilibrium points at the d roots of unity, d odd. In proving that such vector fields are generic...

  4. Transversals of Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    by rotational constants. Transversals are a certain class of curves for such a family of vector fields that represent the bifurcation states for this family of vector fields. More specifically, transversals are curves that coincide with a homoclinic separatrix for some rotation of the vector field. Given......Vector fields in the complex plane are defined by assigning the vector determined by the value P(z) to each point z in the complex plane, where P is a polynomial of one complex variable. We consider special families of so-called rotated vector fields that are determined by a polynomial multiplied...... examples of rotated families to argue this. There will be discussed several open questions concerning the number of transversals that can appear for a certain degree d of a polynomial vector field, and furthermore how transversals are analyzed with respect to bifurcations around multiple equilibrium points....

  5. The vector algebra war: A historical perspective

    CERN Document Server

    Chappell, James M; Hartnett, John G; Abbott, Derek

    2015-01-01

    There are a wide variety of different vector formalisms currently utilized in science. For example, Gibbs three-vectors, spacetime four-vectors, complex spinors for quantum mechanics, quaternions used for rigid body rotations and Clifford multivectors. With such a range of vector formalisms in use, it thus appears that there is as yet no general agreement on a vector formalism suitable for the whole of science. This surprising situation exists today, despite the fact that one of the main goals of nineteenth century science was to correctly describe vectors and the algebra of three-dimensional space. This situation has also had the unfortunate consequence of fragmenting knowledge across many disciplines and requiring a very significant amount of time and effort in learning the different formalisms. We thus review historically the development of our various vector systems and conclude that the Clifford algebra multivector fulfills the goal of correctly describing vectorial quantities in three dimensions.

  6. Hybrid reactors. [Fuel cycle

    Energy Technology Data Exchange (ETDEWEB)

    Moir, R.W.

    1980-09-09

    The rationale for hybrid fusion-fission reactors is the production of fissile fuel for fission reactors. A new class of reactor, the fission-suppressed hybrid promises unusually good safety features as well as the ability to support 25 light-water reactors of the same nuclear power rating, or even more high-conversion-ratio reactors such as the heavy-water type. One 4000-MW nuclear hybrid can produce 7200 kg of /sup 233/U per year. To obtain good economics, injector efficiency times plasma gain (eta/sub i/Q) should be greater than 2, the wall load should be greater than 1 MW.m/sup -2/, and the hybrid should cost less than 6 times the cost of a light-water reactor. Introduction rates for the fission-suppressed hybrid are usually rapid.

  7. Hybrid propulsion technology program

    Science.gov (United States)

    1990-01-01

    Technology was identified which will enable application of hybrid propulsion to manned and unmanned space launch vehicles. Two design concepts are proposed. The first is a hybrid propulsion system using the classical method of regression (classical hybrid) resulting from the flow of oxidizer across a fuel grain surface. The second system uses a self-sustaining gas generator (gas generator hybrid) to produce a fuel rich exhaust that was mixed with oxidizer in a separate combustor. Both systems offer cost and reliability improvement over the existing solid rocket booster and proposed liquid boosters. The designs were evaluated using life cycle cost and reliability. The program consisted of: (1) identification and evaluation of candidate oxidizers and fuels; (2) preliminary evaluation of booster design concepts; (3) preparation of a detailed point design including life cycle costs and reliability analyses; (4) identification of those hybrid specific technologies needing improvement; and (5) preperation of a technology acquisition plan and large scale demonstration plan.

  8. Simulation of Liquid Injection Thrust Vector Control for Mars Ascent Vehicle

    Science.gov (United States)

    Gudenkauf, Jared

    2017-01-01

    The Jet Propulsion Laboratory is currently in the initial design phase for a potential Mars Ascent Vehicle; which will be landed on Mars, stay on the surface for period of time, collect samples from the Mars 2020 rover, and then lift these samples into orbit around Mars. The engineers at JPL have down selected to a hybrid wax-based fuel rocket using a liquid oxidizer based on nitrogen tetroxide, or a Mixed Oxide of Nitrogen. To lower the gross lift-off mass of the vehicle the thrust vector control system will use liquid injection of the oxidizer to deflect the thrust of the main nozzle instead of using a gimbaled nozzle. The disadvantage of going with the liquid injection system is the low technology readiness level with a hybrid rocket. Presented in this paper is an effort to simulate the Mars Ascent Vehicle hybrid rocket nozzle and liquid injection thrust vector control system using the computational fluid dynamic flow solver Loci/Chem. This effort also includes determining the sensitivity of the thrust vector control system to a number of different design variables for the injection ports; including axial location, number of adjacent ports, injection angle, and distance between the ports.

  9. Some theoretical comparisons of refined Ritz vectors and Ritz vectors

    Institute of Scientific and Technical Information of China (English)

    JIA Zhongxiao

    2004-01-01

    Refined projection methods proposed by the author have received attention internationally. We are concerned with a conventional projection method and its refined counterpart for computing approximations to a simple eigenpair (λ,x)of a large matrix A. Given a subspace w that contains anapproximation to x, these two methods compute approximations(μ(x~)) and (μ(x^)) to (λ,x),respectively. We establish three results. First, the refinedeigenvector approximation or simply the refined Ritz vector (x^) is unique as the deviation of x from w approaches zero if λ is simple. Second, interms of residual norm of the refined approximate eigenpair (μ,(x^)), we derive lower and upper bounds for the sine of the angle betweenthe Ritz vector (x~) and the refined eigenvector approximation (x^), and we prove that (x~)≠(x^) unless (x^)=x. Third, we establish relationships between theresidual norm ‖A(x~)-μ(x^)‖ of the conventionalmethods and the residual norm ‖A(x^)-μ(x^)‖ of therefined methods, and we show that the latter is always smallerthan the former if (μ,(x^)) is not an exact eigenpair ofA, indicating that the refined projection method is superiorto the corresponding conventional counterpart.

  10. Some theoretical comparisons of refined Ritz vectors and Ritz vectors

    Institute of Scientific and Technical Information of China (English)

    JIA; Zhongxiao

    2004-01-01

    Refined projection methods proposed by the author have received attention internationally. We are concerned with a conventional projection method and its refined counterpart for computing approximations to a simple eigenpair (λ,x)of a large matrix A. Given a subspace w that contains anapproximation to x, these two methods compute approximations(μ(x~)) and (μ(x)) to (λ,x),respectively. We establish three results. First, the refinedeigenvector approximation or simply the refined Ritz vector (x) is unique as the deviation of x from w approaches zero if λ is simple. Second, interms of residual norm of the refined approximate eigenpair (μ,(x)), we derive lower and upper bounds for the sine of the angle betweenthe Ritz vector (x~) and the refined eigenvector approximation (x), and we prove that (x~)≠(x) unless (x)=x. Third, we establish relationships between theresidual norm ‖A(x~)-μ(x)‖ of the conventionalmethods and the residual norm ‖A(x)-μ(x)‖ of therefined methods, and we show that the latter is always smallerthan the former if (μ,(x)) is not an exact eigenpair ofA, indicating that the refined projection method is superiorto the corresponding conventional counterpart.

  11. Vector meson electroproduction in QCD

    Institute of Scientific and Technical Information of China (English)

    LU Juan; CAI Xian-Hao; ZHOU Li-Juan

    2012-01-01

    Based on the generalized QCD vector meson dominance model,we study the electroproduction of a vector meson off a proton in the QCD inspired eikonalized model.Numerical calculations for the total cross section σtot and differential cross section dσ/dt are performed for p,ω and φ meson electroproduction in this paper.Since gluons interact among themselves (self-interaction),two gluons can form a glueball with quantum numbers IG,JPC =0+,2++,decay width Γt ≈ 100 MeV,and mass of mG=2.23 GeV.The three gluons can form a three-gluon colorless bound state with charge conjugation quantum number C =-1,called the Odderon.The mediators of interactions between projectiles (the quark and antiquark pair fluctuated from the virtual photon) and the proton target (a three-quark system) are the tensor glueball and the Odderon.Our calculated results in the tensor glueball and Odderon exchange model fit to the existing data successfully,which evidently shows that our present QCD mechanism is a good description of meson electroproduction off a proton.It should be emphasized that our mechanism is different from the theoretical framework of Block et al.We also believe that the present study and its success are important for the investigation of other vector meson electro- and photoproduction at high energies,as well as for searching for new particles such as tensor glueballs and Odderons,which have been predicted by QCD and the color glass condensate model (CGC).Therefore,in return,it can test the validity of QCD and the CGC model.

  12. Vector meson electroproduction in QCD

    Science.gov (United States)

    Lu, Juan; Cai, Xian-Hao; Zhou, Li-Juan

    2012-08-01

    Based on the generalized QCD vector meson dominance model, we study the electroproduction of a vector meson off a proton in the QCD inspired eikonalized model. Numerical calculations for the total cross section σtot and differential cross section dσ/dt are performed for ρ, ω and varphi meson electroproduction in this paper. Since gluons interact among themselves (self-interaction), two gluons can form a glueball with quantum numbers IG, JPC = 0+,2++, decay width Γt ≈ 100 MeV, and mass of mG = 2.23 GeV. The three gluons can form a three-gluon colorless bound state with charge conjugation quantum number C = -1, called the Odderon. The mediators of interactions between projectiles (the quark and antiquark pair fluctuated from the virtual photon) and the proton target (a three-quark system) are the tensor glueball and the Odderon. Our calculated results in the tensor glueball and Odderon exchange model fit to the existing data successfully, which evidently shows that our present QCD mechanism is a good description of meson electroproduction off a proton. It should be emphasized that our mechanism is different from the theoretical framework of Block et al. We also believe that the present study and its success are important for the investigation of other vector meson electro- and photoproduction at high energies, as well as for searching for new particles such as tensor glueballs and Odderons, which have been predicted by QCD and the color glass condensate model (CGC). Therefore, in return, it can test the validity of QCD and the CGC model.

  13. Nonviral Vectors for Gene Delivery

    Science.gov (United States)

    Baoum, Abdulgader Ahmed

    2011-12-01

    The development of nonviral vectors for safe and efficient gene delivery has been gaining considerable attention recently. An ideal nonviral vector must protect the gene against degradation by nuclease in the extracellular matrix, internalize the plasma membrane, escape from the endosomal compartment, unpackage the gene at some point and have no detrimental effects. In comparison to viruses, nonviral vectors are relatively easy to synthesize, less immunogenic, low in cost, and have no limitation in the size of a gene that can be delivered. Significant progress has been made in the basic science and applications of various nonviral gene delivery vectors; however, the majority of nonviral approaches are still inefficient and often toxic. To this end, two nonviral gene delivery systems using either biodegradable poly(D,L-lactide- co-glycolide) (PLG) nanoparticles or cell penetrating peptide (CPP) complexes have been designed and studied using A549 human lung epithelial cells. PLG nanoparticles were optimized for gene delivery by varying particle surface chemistry using different coating materials that adsorb to the particle surface during formation. A variety of cationic coating materials were studied and compared to more conventional surfactants used for PLG nanoparticle fabrication. Nanoparticles (˜200 nm) efficiently encapsulated plasmids encoding for luciferase (80-90%) and slowly released the same for two weeks. After a delay, moderate levels of gene expression appeared at day 5 for certain positively charged PLG particles and gene expression was maintained for at least two weeks. In contrast, gene expression mediated by polyethyleneimine (PEI) ended at day 5. PLG particles were also significantly less cytotoxic than PEI suggesting the use of these vehicles for localized, sustained gene delivery to the pulmonary epithelium. On the other hand, a more simple method to synthesize 50-200 nm complexes capable of high transfection efficiency or high gene knockdown was

  14. On Weighted Support Vector Regression

    DEFF Research Database (Denmark)

    Han, Xixuan; Clemmensen, Line Katrine Harder

    2014-01-01

    We propose a new type of weighted support vector regression (SVR), motivated by modeling local dependencies in time and space in prediction of house prices. The classic weights of the weighted SVR are added to the slack variables in the objective function (OF‐weights). This procedure directly...... the differences and similarities of the two types of weights by demonstrating the connection between the Least Absolute Shrinkage and Selection Operator (LASSO) and the SVR. We show that an SVR problem can be transformed to a LASSO problem plus a linear constraint and a box constraint. We demonstrate...

  15. Probability Ranking in Vector Spaces

    CERN Document Server

    Melucci, Massimo

    2011-01-01

    The Probability Ranking Principle states that the document set with the highest values of probability of relevance optimizes information retrieval effectiveness given the probabilities are estimated as accurately as possible. The key point of the principle is the separation of the document set into two subsets with a given level of fallout and with the highest recall. The paper introduces the separation between two vector subspaces and shows that the separation yields a more effective performance than the optimal separation into subsets with the same available evidence, the performance being measured with recall and fallout. The result is proved mathematically and exemplified experimentally.

  16. A Hybrid Prognostic Approach for Remaining Useful Life Prediction of Lithium-Ion Batteries

    Directory of Open Access Journals (Sweden)

    Wen-An Yang

    2016-01-01

    Full Text Available Lithium-ion battery is a core component of many systems such as satellite, spacecraft, and electric vehicles and its failure can lead to reduced capability, downtime, and even catastrophic breakdowns. Remaining useful life (RUL prediction of lithium-ion batteries before the future failure event is extremely crucial for proactive maintenance/safety actions. This study proposes a hybrid prognostic approach that can predict the RUL of degraded lithium-ion batteries using physical laws and data-driven modeling simultaneously. In this hybrid prognostic approach, the relevant vectors obtained with the selective kernel ensemble-based relevance vector machine (RVM learning algorithm are fitted to the physical degradation model, which is then extrapolated to failure threshold for estimating the RUL of the lithium-ion battery of interest. The experimental results indicated that the proposed hybrid prognostic approach can accurately predict the RUL of degraded lithium-ion batteries. Empirical comparisons show that the proposed hybrid prognostic approach using the selective kernel ensemble-based RVM learning algorithm performs better than the hybrid prognostic approaches using the popular learning algorithms of feedforward artificial neural networks (ANNs like the conventional backpropagation (BP algorithm and support vector machines (SVMs. In addition, an investigation is also conducted to identify the effects of RVM learning algorithm on the proposed hybrid prognostic approach.

  17. Weyl gauge-vector and complex dilaton scalar for conformal symmetry and its breaking

    Science.gov (United States)

    Ohanian, Hans C.

    2016-03-01

    Instead of the scalar "dilaton" field that is usually adopted to construct conformally invariant Lagrangians for gravitation, we here propose a hybrid construction, involving both a complex dilaton scalar and a Weyl gauge-vector, in accord with Weyl's original concept of a non-Riemannian conformal geometry with a transport law for length and time intervals, for which this gauge vector is required. Such a hybrid construction permits us to avoid the wrong sign of the dilaton kinetic term (the ghost problem) that afflicts the usual construction. The introduction of a Weyl gauge-vector and its interaction with the dilaton also has the collateral benefit of providing an explicit mechanism for spontaneous breaking of the conformal symmetry, whereby the dilaton and the Weyl gauge-vector acquire masses somewhat smaller than {m}_{P} by the Coleman-Weinberg mechanism. Conformal symmetry breaking is assumed to precede inflation, which occurs later by a separate GUT or electroweak symmetry breaking, as in inflationary models based on the Higgs boson.

  18. Vector-tensor and vector-vector decay amplitude analysis of B0-->phiK*0.

    Science.gov (United States)

    Aubert, B; Bona, M; Boutigny, D; Couderc, F; Karyotakis, Y; Lees, J P; Poireau, V; Tisserand, V; Zghiche, A; Grauges, E; Palano, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Gill, M S; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Pegna, D Lopes; Lynch, G; Mir, L M; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Wenzel, W A; Sanchez, P del Amo; Barrett, M; Ford, K E; Harrison, T J; Hart, A J; Hawkes, C M; Watson, A T; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schroeder, T; Steinke, M; Boyd, J T; Burke, J P; Cottingham, W N; Walker, D; Asgeirsson, D J; Cuhadar-Donszelmann, T; Fulsom, B G; Hearty, C; Knecht, N S; Mattison, T S; McKenna, J A; Khan, A; Kyberd, P; Saleem, M; Sherwood, D J; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Best, D S; Bondioli, M; Bruinsma, M; Chao, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M; Roethel, W; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Long, O; Shen, B C; Wang, K; Zhang, L; Hadavand, H K; Hill, E J; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Nesom, G; Schalk, T; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Cheng, C H; Dvoretskii, A; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Ruddick, W O; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Chen, A; Eckhart, E A; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Zeng, Q; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Merkel, J; Petzold, A; Spaan, B; Brandt, T; Klose, V; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Thiebaux, Ch; Verderi, M; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Contri, R; Vetere, M Lo; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Brandenburg, G; Chaisanguanthum, K S; Lee, C L; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Flack, R L; Nash, J A; Nikolich, M B; Vazquez, W Panduro; Behera, P K; Chai, X; Charles, M J; Mallik, U; Meyer, N T; Ziegler, V; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gao, Y; Gritsan, A V; Guo, Z J; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Davier, M; Grosdidier, G; Höcker, A; Lepeltier, V; Diberder, F Le; Lutz, A M; Oyanguren, A; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Serrano, J; Stocchi, A; Wang, W F; Wormser, G; Lange, D J; Wright, D M; Chavez, C A; Forster, I J; Fry, J R; Gabathuler, E; Gamet, R; George, K A; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; Clarke, C K; Lodovico, F Di; Menges, W; Sacco, R; Cowan, G; Flaecher, H U; Hopkins, D A; Jackson, P S; McMahon, T R; Salvatore, F; Wren, A C; Brown, D N; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; Naisbit, M T; Williams, J C; Yi, J I; Chen, C; Hulsbergen, W D; Jawahery, A; Lae, C K; Roberts, D A; Simi, G; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Saremi, S; Staengle, H; Cowan, R; Sciolla, G; Sekula, S J; Spitznagel, M; Taylor, F; Yamamoto, R K; Kim, H; McLachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; Cavallo, N; Nardo, G De; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; Losecco, J M; Benelli, G; Corwin, L A; Gan, K K; Honscheid, K; Hufnagel, D; Jackson, P D; Kagan, H; Kass, R; Rahimi, A M; Regensburger, J J; Ter-Antonyan, R; Wong, Q K; Blount, N L; Brau, J; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Potter, C T; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; Buono, L Del; de la Vaissière, Ch; Hamon, O; Hartfiel, B L; Leruste, Ph; Malclès, J; Ocariz, J; Roos, L; Therin, G; Gladney, L; Biasini, M; Covarelli, R; Angelini, C; Batignani, G; Bettarini, S; Bucci, F; Calderini, G; Carpinelli, M; Cenci, R; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Haire, M; Judd, D; Wagoner, D E; Biesiada, J; Danielson, N; Elmer, P; Lau, Y P; Lu, C; Olsen, J; Smith, A J S; Telnov, A V; Bellini, F; Cavoto, G; D'Orazio, A; del Re, D; Marco, E Di; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Gioi, L Li; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Tehrani, F Safai; Voena, C; Ebert, M; Schröder, H; Waldi, R; Adye, T; Franek, B; Olaiya, E O; Ricciardi, S; Wilson, F F; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; de Monchenault, G Hamel; Kozanecki, W; Legendre, M; Vasseur, G; Yèche, Ch; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Berger, N; Claus, R; Coleman, J P; Convery, M R; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Grenier, P; Halyo, V; Hast, C; Hryn'ova, T; Innes, W R; Kelsey, M H; Kim, P; Leith, D W G S; Li, S; Luitz, S; Luth, V; Lynch, H L; Macfarlane, D B; Marsiske, H; Messner, R; Muller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Va'vra, J; van Bakel, N; Wagner, A P; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wittgen, M; Wright, D H; Wulsin, H W; Yarritu, A K; Yi, K; Young, C C; Burchat, P R; Edwards, A J; Majewski, S A; Petersen, B A; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Ritchie, J L; Satpathy, A; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Ricca, G Della; Dittongo, S; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martinez-Vidal, F; Banerjee, Sw; Bhuyan, B; Brown, C M; Fortin, D; Hamano, K; Kowalewski, R; Nugent, I M; Roney, J M; Sobie, R J; Back, J J; Harrison, P F; Latham, T E; Mohanty, G B; Pappagallo, M; Band, H R; Chen, X; Cheng, B; Dasu, S; Datta, M; Flood, K T; Hollar, J J; Kutter, P E; Mellado, B; Mihalyi, A; Pan, Y; Pierini, M; Prepost, R; Wu, S L; Yu, Z; Neal, H

    2007-02-02

    We perform an amplitude analysis of the decays B(0)-->phiK*(2)(1430)(0), phiK*(892)(0), and phi(Kpi)(0)(S-wave) with a sample of about 384x10(6) BB[over ] pairs recorded with the BABAR detector. The fractions of longitudinal polarization f(L) of the vector-tensor and vector-vector decay modes are measured to be 0.853(-0.069+0.061)+/-0.036 and 0.506+/-0.040+/-0.015, respectively. Overall, twelve parameters are measured for the vector-vector decay and seven parameters for the vector-tensor decay, including the branching fractions and parameters sensitive to CP violation.

  19. Current progress of polymeric gene vectors

    Institute of Scientific and Technical Information of China (English)

    ZENG Xuan; SUN YunXia; ZHUO RenXi; ZHANG XianZheng

    2011-01-01

    After over 40 years ot progress,gene therapy provides great opportunities for treating diseases from various genetic disorders,infections and cancers.The success of gene therapy largely depends on the availability of suitable gene vectors.As an attractive alternative to virus-based gene therapy,non-viral gene delivery system has been developed and investigated due to their merits including low immunogenecity,convenient operability,and large-scale manufacturability [1].Because polycations can condense with DNA as a result of electrostatic interactions,form nanosize polyplexes,and protect DNA from degradation by DNase,cationic polymer becomes a major type of non-viral gene delivery vectors (Figure 1) [2].A wide range of polymeric vectors have been developed and investigated in the past decade,such as polyethylenimine (PEI)-based vectors,poly(L-lysine) (PLL)-based vectors,dendrimer-based vectors,polypeptide-based vectors,and chitosan-based vectors [3].However,unlike viral vectors that have the ability to infect host cells and overcome cellular barriers through the course of evolution,nonviral gene vectors exhibit Significantly reduced transfection efficiency as they are obstructed by various extra- and intracellular barriers,including serum proteins in blood stream,cell membrane,endosomal compartment and nuclear membrane [4].

  20. Therapeutic and prophylactic applications of alphavirus vectors.

    Science.gov (United States)

    Atkins, Gregory J; Fleeton, Marina N; Sheahan, Brian J

    2008-11-11

    Alphavirus vectors are high-level, transient expression vectors for therapeutic and prophylactic use. These positive-stranded RNA vectors, derived from Semliki Forest virus, Sindbis virus and Venezuelan equine encephalitis virus, multiply and are expressed in the cytoplasm of most vertebrate cells, including human cells. Part of the genome encoding the structural protein genes, which is amplified during a normal infection, is replaced by a transgene. Three types of vector have been developed: virus-like particles, layered DNA-RNA vectors and replication-competent vectors. Virus-like particles contain replicon RNA that is defective since it contains a cloned gene in place of the structural protein genes, and thus are able to undergo only one cycle of expression. They are produced by transfection of vector RNA, and helper RNAs encoding the structural proteins. Layered DNA-RNA vectors express the Semliki Forest virus replicon from a cDNA copy via a cytomegalovirus promoter. Replication-competent vectors contain a transgene in addition to the structural protein genes. Alphavirus vectors are used for three main applications: vaccine construction, therapy of central nervous system disease, and cancer therapy.

  1. Vector-Resonance-Multimode Instability

    Science.gov (United States)

    Sergeyev, S. V.; Kbashi, H.; Tarasov, N.; Loiko, Yu.; Kolpakov, S. A.

    2017-01-01

    The modulation and multimode instabilities are the main mechanisms which drive spontaneous spatial and temporal pattern formation in a vast number of nonlinear systems ranging from biology to laser physics. Using an Er-doped fiber laser as a test bed, here for the first time we demonstrate both experimentally and theoretically a new type of a low-threshold vector-resonance-multimode instability which inherits features of multimode and modulation instabilities. The same as for the multimode instability, a large number of longitudinal modes can be excited without mode synchronization. To enable modulation instability, we modulate the state of polarization of the lasing signal with the period of the beat length by an adjustment of the in-cavity birefringence and the state of polarization of the pump wave. As a result, we show the regime's tunability from complex oscillatory to periodic with longitudinal mode synchronization in the case of resonance matching between the beat and cavity lengths. Apart from the interest in laser physics for unlocking the tunability and stability of dynamic regimes, the proposed mechanism of the vector-resonance-multimode instability can be of fundamental interest for the nonlinear dynamics of various distributed systems.

  2. The vector BPS Skyrme model

    CERN Document Server

    Adam, C; Sanchez-Guillen, J; Wereszczynski, A

    2012-01-01

    We analyze the vector meson formulation of the BPS Skyrme model in (3+1) dimensions, where the term of sixth power in first derivatives characteristic for the original, integrable BPS Skyrme model (the topological or baryon current squared) is replaced by a coupling between the vector meson $\\omega_\\mu$ and the baryon current. We find that the model remains integrable in the sense of generalized integrability and almost solvable (reducible to a set of two first order ODEs) for any value of the baryon charge. Further, we analyze the appearance of topological solitons for two one-parameter families of one vacuum potentials: the old Skyrme potentials and the so-called BPS potentials. Depending on the value of the parameters we find several qualitatively different possibilities. In the massless case we have a parameter region with no skyrmions, a unique compact skyrmion with a discontinuous first derivative at the boundary (equivalently, with a source term located at the boundary, which screens the topological ch...

  3. A concurrent vector-based steering framework for particle transport

    CERN Document Server

    Apostolakis, John; Carminati, Federico; Gheata, Andrei; Wenzel, Sandro

    2014-01-01

    High Energy Physics has traditionally been a technology - limited science that has pushed the boundaries of both the detectors collecting the information about the particles and the computing infrastructure processing this information. However, since a few years the increase in computing power comes in the form of increased parallelism at all levels, and High Energy Physics has now to optimise its code to take advantage of the new architectures, including GPUs and hybrid systems. One of the primary targets for optimisation is the particle transport code used to simulate the detector response, as it is largely experiment independent and one of the most demanding applications in terms of CPU resources . The Geant Vector Prototype project aims to explore innovative designs in particle transport aimed at obtaining maximal performance on the new architectures. This paper describes the current status of the project and its future perspectives. In particular we describe how the present design tries to expose the par...

  4. Hybrid electric vehicles TOPTEC

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-06-21

    This one-day TOPTEC session began with an overview of hybrid electric vehicle technology. Updates were given on alternative types of energy storage, APU control for low emissions, simulation programs, and industry and government activities. The keynote speech was about battery technology, a key element to the success of hybrids. The TOPEC concluded with a panel discussion on the mission of hybrid electric vehicles, with a perspective from industry and government experts from United States and Canada on their view of the role of this technology.

  5. Hybrid systems with constraints

    CERN Document Server

    Daafouz, Jamal; Sigalotti, Mario

    2013-01-01

    Control theory is the main subject of this title, in particular analysis and control design for hybrid dynamic systems.The notion of hybrid systems offers a strong theoretical and unified framework to cope with the modeling, analysis and control design of systems where both continuous and discrete dynamics interact. The theory of hybrid systems has been the subject of intensive research over the last decade and a large number of diverse and challenging problems have been investigated. Nevertheless, many important mathematical problems remain open.This book is dedicated mainly to

  6. Hybrid Bloch Brane

    CERN Document Server

    Bazeia, D; Losano, L

    2016-01-01

    This work reports on models described by two real scalar fields coupled with gravity in the five-dimensional spacetime, with a warped geometry involving one infinite extra dimension. Through a mechanism that smoothly changes a thick brane into a hybrid brane, one investigates the appearance of hybrid branes hosting internal structure, characterized by the splitting on the energy density and the volcano potential, induced by the parameter which controls interactions between the two scalar fields. In particular, we investigate distinct symmetric and asymmetric hybrid brane scenarios.

  7. Hybrid Bloch brane

    Energy Technology Data Exchange (ETDEWEB)

    Bazeia, D.; Lima, Elisama E.M.; Losano, L. [Universidade Federal da Paraiba, Departamento de Fisica, Joao Pessoa, PB (Brazil)

    2017-02-15

    This work reports on models described by two real scalar fields coupled with gravity in the five-dimensional spacetime, with a warped geometry involving one infinite extra dimension. Through a mechanism that smoothly changes a thick brane into a hybrid brane, one investigates the appearance of hybrid branes hosting internal structure, characterized by the splitting on the energy density and the volcano potential, induced by the parameter which controls interactions between the two scalar fields. In particular, we investigate distinct symmetric and asymmetric hybrid brane scenarios. (orig.)

  8. Hybrid silicon evanescent devices

    Directory of Open Access Journals (Sweden)

    Alexander W. Fang

    2007-07-01

    Full Text Available Si photonics as an integration platform has recently been a focus of optoelectronics research because of the promise of low-cost manufacturing based on the ubiquitous electronics fabrication infrastructure. The key challenge for Si photonic systems is the realization of compact, electrically driven optical gain elements. We review our recent developments in hybrid Si evanescent devices. We have demonstrated electrically pumped lasers, amplifiers, and photodetectors that can provide a low-cost, scalable solution for hybrid integration on a Si platform by using a novel hybrid waveguide architecture, consisting of III-V quantum wells bonded to Si waveguides.

  9. A hybrid structure for the storage and manipulation of very large spatial data sets

    Science.gov (United States)

    Peuquet, Donna J.

    1982-01-01

    The map data input and output problem for geographic information systems is rapidly diminishing with the increasing availability of mass digitizing, direct spatial data capture and graphics hardware based on raster technology. Although a large number of efficient raster-based algorithms exist for performing a wide variety of common tasks on these data, there are a number of procedures which are more efficiently performed in vector mode or for which raster mode equivalents of current vector-based techniques have not yet been developed. This paper presents a hybrid spatial data structure, named the ?vaster' structure, which can utilize the advantages of both raster and vector structures while potentially eliminating, or greatly reducing, the need for raster-to-vector and vector-to-raster conversion. Other advantages of the vaster structure are also discussed.

  10. A Modified Moist Ageostrophic Q Vector

    Institute of Scientific and Technical Information of China (English)

    YUE Caijun; SHOU Shaowen

    2008-01-01

    The quasi-geostrophic Q vector is an important diagnostic tool for studying development of surface rainfall associated with large-scale weather systems and is calculated using data at single vertical level. When ageostrophic Q vector was introduced, it required data at two vertical levels. In this study, moist ageostrophic Q vector is modified so that it can be calculated using data at a single vertical level. The comparison study between the original and modified moist ageostrophic Q vectors is conducted using the data from 5 to 6 July 1991 during the torrential rainfall event associated with the Changjiang-Huaihe mei-yu front in China. The results reveal that divergences of original and modified moist ageostrophic Q vectors have similar horizontal distributions and their centers are almost located in the precipitation centers. This indicates that modified moist ageostrophic Q vector can be used to diagnose convective development with reasonable accuracy.

  11. Vector assembly of colloids on monolayer substrates

    Science.gov (United States)

    Jiang, Lingxiang; Yang, Shenyu; Tsang, Boyce; Tu, Mei; Granick, Steve

    2017-06-01

    The key to spontaneous and directed assembly is to encode the desired assembly information to building blocks in a programmable and efficient way. In computer graphics, raster graphics encodes images on a single-pixel level, conferring fine details at the expense of large file sizes, whereas vector graphics encrypts shape information into vectors that allow small file sizes and operational transformations. Here, we adapt this raster/vector concept to a 2D colloidal system and realize `vector assembly' by manipulating particles on a colloidal monolayer substrate with optical tweezers. In contrast to raster assembly that assigns optical tweezers to each particle, vector assembly requires a minimal number of optical tweezers that allow operations like chain elongation and shortening. This vector approach enables simple uniform particles to form a vast collection of colloidal arenes and colloidenes, the spontaneous dissociation of which is achieved with precision and stage-by-stage complexity by simply removing the optical tweezers.

  12. Chaotic mixer improves microarray hybridization.

    Science.gov (United States)

    McQuain, Mark K; Seale, Kevin; Peek, Joel; Fisher, Timothy S; Levy, Shawn; Stremler, Mark A; Haselton, Frederick R

    2004-02-15

    Hybridization is an important aspect of microarray experimental design which influences array signal levels and the repeatability of data within an array and across different arrays. Current methods typically require 24h and use target inefficiently. In these studies, we compare hybridization signals obtained in conventional static hybridization, which depends on diffusional target delivery, with signals obtained in a dynamic hybridization chamber, which employs a fluid mixer based on chaotic advection theory to deliver targets across a conventional glass slide array. Microarrays were printed with a pattern of 102 identical probe spots containing a 65-mer oligonucleotide capture probe. Hybridization of a 725-bp fluorescently labeled target was used to measure average target hybridization levels, local signal-to-noise ratios, and array hybridization uniformity. Dynamic hybridization for 1h with 1 or 10ng of target DNA increased hybridization signal intensities approximately threefold over a 24-h static hybridization. Similarly, a 10- or 60-min dynamic hybridization of 10ng of target DNA increased hybridization signal intensities fourfold over a 24h static hybridization. In time course studies, static hybridization reached a maximum within 8 to 12h using either 1 or 10ng of target. In time course studies using the dynamic hybridization chamber, hybridization using 1ng of target increased to a maximum at 4h and that using 10ng of target did not vary over the time points tested. In comparison to static hybridization, dynamic hybridization reduced the signal-to-noise ratios threefold and reduced spot-to-spot variation twofold. Therefore, we conclude that dynamic hybridization based on a chaotic mixer design improves both the speed of hybridization and the maximum level of hybridization while increasing signal-to-noise ratios and reducing spot-to-spot variation.

  13. Integrated epidemiology for vector-borne zoonoses

    OpenAIRE

    2016-01-01

    The development and application of interventions for the control of vector-borne zoonoses requires broad understanding of epidemiological linkages between vector, animal infection and human infection. However, there are significant gaps in our understanding of these linkages and a lack of appropriate data poses a considerable barrier to addressing this issue. A move towards strengthened surveillance of vectors and disease in both animal and human hosts, in combination with linked human-animal...

  14. Higgs Decays and Brane Gravi-vectors

    OpenAIRE

    Clark, T. E.; Liu, B. Y.; Love, S. T.; Xiong, C.; ter Veldhuis, T.

    2008-01-01

    Higgs boson decays in flexible brane world models with stable, massive gravi-vectors are considered. Such vectors couple bilinearly to the Standard Model fields through either the Standard Model energy-momentum tensor, the weak hypercharge field strength or the Higgs scalar. The role of the coupling involving the extrinsic curvature is highlighted. It is found that within the presently allowed parameter space, the decay rate of the Higgs into two gravi-vectors (which would appear as an invisi...

  15. [Research progress on malaria vector control].

    Science.gov (United States)

    Zhu, Guo-Ding; Cao, Jun; Zhou, Hua-Yun; Gao, Qi

    2013-06-01

    Vector control plays a crucial role in the stages of malaria control and elimination. Currently, it mainly relies on the chemical control methods for adult mosquitoes in malaria endemic areas, however, it is undergoing the serious threat by insecticide resistance. In recent years, the transgenic technologies of malaria vectors have made a great progress in the laboratory. This paper reviews the challenges of the traditional methods and the rapid developed genetic modified technology in the application of vector control.

  16. Construction of shRNA lentiviral vector

    Directory of Open Access Journals (Sweden)

    Hong Song

    2010-12-01

    Full Text Available Lentiviruses have been adapted as gene delivery vehicles. This article summarized shRNA lentiviral vector methods generally used in research laboratories. The main procedures of shRNA lentiviral vector include that (1 Target sequences screening and shRNA oligonucleotides designing, (2 insert designed oligonucleotides into lentiviral vectors, (3 using packaging cells to produce shRNA lentivirus, and (4 transducing target cells with shRNA lentivirus.

  17. Genetic manipulation of endosymbionts to control vector and vector borne diseases

    Directory of Open Access Journals (Sweden)

    Jay Prakash Gupta

    Full Text Available Vector borne diseases (VBD are on the rise because of failure of the existing methods of control of vector and vector borne diseases and the climate change. A steep rise of VBDs are due to several factors like selection of insecticide resistant vector population, drug resistant parasite population and lack of effective vaccines against the VBDs. Environmental pollution, public health hazard and insecticide resistant vector population indicate that the insecticides are no longer a sustainable control method of vector and vector-borne diseases. Amongst the various alternative control strategies, symbiont based approach utilizing endosymbionts of arthropod vectors could be explored to control the vector and vector borne diseases. The endosymbiont population of arthropod vectors could be exploited in different ways viz., as a chemotherapeutic target, vaccine target for the control of vectors. Expression of molecules with antiparasitic activity by genetically transformed symbiotic bacteria of disease-transmitting arthropods may serve as a powerful approach to control certain arthropod-borne diseases. Genetic transformation of symbiotic bacteria of the arthropod vector to alter the vector’s ability to transmit pathogen is an alternative means of blocking the transmission of VBDs. In Indian scenario, where dengue, chikungunya, malaria and filariosis are prevalent, paratransgenic based approach can be used effectively. [Vet World 2012; 5(9.000: 571-576

  18. Hybrid polymer microspheres

    Science.gov (United States)

    Rembaum, A.

    1980-01-01

    Techniques have been successfully tested for bonding polymeric spheres, typically 0.1 micron in diameter, to spheres with diameter up to 100 microns. Hybrids are being developed as improved packing material for ion-exchange columns, filters, and separators.

  19. Hybrid adsorptive membrane reactor

    Science.gov (United States)

    Tsotsis, Theodore T. (Inventor); Sahimi, Muhammad (Inventor); Fayyaz-Najafi, Babak (Inventor); Harale, Aadesh (Inventor); Park, Byoung-Gi (Inventor); Liu, Paul K. T. (Inventor)

    2011-01-01

    A hybrid adsorbent-membrane reactor in which the chemical reaction, membrane separation, and product adsorption are coupled. Also disclosed are a dual-reactor apparatus and a process using the reactor or the apparatus.

  20. Hybrid photon detectors

    CERN Document Server

    D'Ambrosio, C

    2003-01-01

    Hybrid photon detectors detect light via vacuum photocathodes and accelerate the emitted photoelectrons by an electric field towards inversely polarized silicon anodes, where they are absorbed, thus producing electron-hole pairs. These, in turn, are collected and generate electronic signals on their ohmic contacts. This review first describes the characteristic properties of the main components of hybrid photon detectors: light entrance windows, photocathodes, and silicon anodes. Then, essential relations describing the trajectories of photoelectrons in electric and magnetic fields and their backscattering from the silicon anodes are derived. Depending on their anode configurations, three families of hybrid photon detectors are presented: hybrid photomultiplier tubes with single anodes for photon counting with high sensitivity and for gamma spectroscopy; multi-anode photon detector tubes with anodes subdivided into square or hexagonal pads for position-sensitive photon detection; imaging silicon pixel array t...

  1. Functional hybrid materials

    National Research Council Canada - National Science Library

    Fahmi, Amir; Pietsch, Torsten; Mendoza, Cesar; Cheval, Nicolas

    2009-01-01

    .... This paper describes our group's achievements towards the development of multifunctional nanostructures via self-assembly of hybrid systems based on the block copolymer PS-b-P4VP and inorganic nanoparticles (NPs...

  2. Hybrid Rocket Technology

    Directory of Open Access Journals (Sweden)

    Sankaran Venugopal

    2011-04-01

    Full Text Available With their unique operational characteristics, hybrid rockets can potentially provide safer, lower-cost avenues for spacecraft and missiles than the current solid propellant and liquid propellant systems. Classical hybrids can be throttled for thrust tailoring, perform in-flight motor shutdown and restart. In classical hybrids, the fuel is stored in the form of a solid grain, requiring only half the feed system hardware of liquid bipropellant engines. The commonly used fuels are benign, nontoxic, and not hazardous to store and transport. Solid fuel grains are not highly susceptible to cracks, imperfections, and environmental temperature and are therefore safer to manufacture, store, transport, and use for launch. The status of development based on the experience of the last few decades indicating the maturity of the hybrid rocket technology is given in brief.Defence Science Journal, 2011, 61(3, pp.193-200, DOI:http://dx.doi.org/10.14429/dsj.61.518

  3. Nitrous Paraffin Hybrid Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Nitrous Oxide Paraffin Hybrid engine (N2OP) is a proposed technology designed to provide small launch vehicles with high specific impulse, indefinitely storable...

  4. Hybrid adsorptive membrane reactor

    Science.gov (United States)

    Tsotsis, Theodore T.; Sahimi, Muhammad; Fayyaz-Najafi, Babak; Harale, Aadesh; Park, Byoung-Gi; Liu, Paul K. T.

    2011-03-01

    A hybrid adsorbent-membrane reactor in which the chemical reaction, membrane separation, and product adsorption are coupled. Also disclosed are a dual-reactor apparatus and a process using the reactor or the apparatus.

  5. Pro jective vector fields on Finsler manifolds

    Institute of Scientific and Technical Information of China (English)

    TIAN Huang-jia

    2014-01-01

    In this paper, we give the equation that characterizes projective vector fields on a Finsler manifold by the local coordinate. Moreover, we obtain a feature of the projective fields on the compact Finsler manifold with non-positive flag curvature and the non-existence of projective vector fields on the compact Finsler manifold with negative flag curvature. Furthermore, we deduce some expectable, but non-trivial relationships between geometric vector fields such as projective, affine, conformal, homothetic and Killing vector fields on a Finsler manifold.

  6. A New Incremental Support Vector Machine Algorithm

    Directory of Open Access Journals (Sweden)

    Wenjuan Zhao

    2012-10-01

    Full Text Available Support vector machine is a popular method in machine learning. Incremental support vector machine algorithm is ideal selection in the face of large learning data set. In this paper a new incremental support vector machine learning algorithm is proposed to improve efficiency of large scale data processing. The model of this incremental learning algorithm is similar to the standard support vector machine. The goal concept is updated by incremental learning. Each training procedure only includes new training data. The time complexity is independent of whole training set. Compared with the other incremental version, the training speed of this approach is improved and the change of hyperplane is reduced.

  7. Vector perturbations of galaxy number counts

    Science.gov (United States)

    Durrer, Ruth; Tansella, Vittorio

    2016-07-01

    We derive the contribution to relativistic galaxy number count fluctuations from vector and tensor perturbations within linear perturbation theory. Our result is consistent with the the relativistic corrections to number counts due to scalar perturbation, where the Bardeen potentials are replaced with line-of-sight projection of vector and tensor quantities. Since vector and tensor perturbations do not lead to density fluctuations the standard density term in the number counts is absent. We apply our results to vector perturbations which are induced from scalar perturbations at second order and give numerical estimates of their contributions to the power spectrum of relativistic galaxy number counts.

  8. Vector perturbations of galaxy number counts

    CERN Document Server

    Durrer, Ruth

    2016-01-01

    We derive the contribution to relativistic galaxy number count fluctuations from vector and tensor perturbations within linear perturbation theory. Our result is consistent with the the relativistic corrections to number counts due to scalar perturbation, where the Bardeen potentials are replaced with line-of-sight projection of vector and tensor quantities. Since vector and tensor perturbations do not lead to density fluctuations the standard density term in the number counts is absent. We apply our results to vector perturbations which are induced from scalar perturbations at second order and give numerical estimates of their contributions to the power spectrum of relativistic galaxy number counts.

  9. Vector interaction enhanced bag model for astrophysical applications

    CERN Document Server

    Klahn, Thomas

    2015-01-01

    For quark matter studies in astrophysics the thermodynamic bag model (tdBAG) has been widely used. Despite its success it fails to account for various phenomena expected from Quantum-Chromo-Dynamics (QCD). We suggest a straightforward extension of tdBAG in order to take the dynamical breaking of chiral symmetry and the influence of vector interactions explicitly into account. As for tdBAG the model mimics confinement in a phenomenological approach. It is based on an analysis of the Nambu--Jona-Lasinio (NJL) model at finite density. Furthermore, we demonstrate how NJL and bag models in this regime follow from the more general and QCD based framework of Dyson-Schwinger (DS) equations in medium by assuming a simple gluon contact interaction. Based on our simple and novel model, we construct quark hadron hybrid equations of state (EoS) and study systematically chiral and deconfinement phase transitions, the appearance of $s$-quarks and the role of vector interaction. We further study these aspects for matter in b...

  10. Application of modified vector fitting to grounding system modeling

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez, D.; Camargo, M.; Herrera, J.; Torres, H. [National University of Colombia (Colombia). Research Program on Acquisition and Analysis of Signals - PAAS], Emails: dyjimeneza@unal.edu.co, mpcamargom@unal.edu.co; Vargas, M. [Siemens S.A. - Power Transmission and Distribution - Energy Services (Colombia)

    2007-07-01

    The transient behavior of grounding systems (GS) influences greatly the performance of electrical networks under fault conditions. This fact has led the authors to present an application of the Modified Vector Fitting (MVF)1 methodology based upon the frequency response of the system, in order to find a rational function approximation and an equivalent electrical network whose transient behavior is similar to the original one of the GS. The obtained network can be introduced into the EMTP/ATP program for simulating the transient behavior of the GS. The MVF technique, which is a modification of the Vector Fitting (VF) technique, allows identifying state space models from the Frequency Domain Response for both single and multiple input-output systems. In this work, the methodology is used to fit the frequency response of a grounding grid, which is computed by means of the Hybrid Electromagnetic Model (HEM), finding the relation between voltages and input currents in two points of the grid in frequency domain. The model obtained with the MVF shows a good agreement with the frequency response of the GS. Besides, the model is tested in EMTP/ATP finding a good fitting with the calculated data, which demonstrates the validity and usefulness of the MVF. (author)

  11. An elusive vector dark matter

    Directory of Open Access Journals (Sweden)

    Chuan-Ren Chen

    2015-02-01

    Full Text Available Even though the sensitivity of direct dark matter search experiments reaches the level of about 10−45 cm2, no confident signal of dark matter has been observed. We point out that, if dark matter is a vector boson, the null result in direct dark matter search experiments may be due to the destructive effects in dark-matter–nucleon elastic scattering. We illustrate the scenario using a modified Higgs portal model that includes exotic quarks. The significant cancellation can occur for a certain mass gap between new heavy quark and dark matter. As a result, the spin-independent dark-matter–nucleon elastic scattering is so suppressed that the future direct search experiments will hardly observe the signal of dark matter.

  12. Synthetic Aperture Vector Flow Imaging

    DEFF Research Database (Denmark)

    Villagómez Hoyos, Carlos Armando

    The main objective of this project was to continue the development of a synthetic aperture vector flow estimator. This type of estimator is capable of overcoming two of the major limitations in conventional ultrasound systems: 1) the inability to scan large region of interest with high temporal...... resolutions; 2) the lack of capability in detecting flow other than the one along the direction of the beam. Addressing these technical limitations would translate in the clinic as a gain in valuable clinical information and a removal of operator-dependant sources of error, which would improve the diagnosis....... The main contribution of this work was the development of an angle estimator which features high accuracy and low standard deviation over the full 360◦ range. The estimator demonstrated its capability of operating at high frame rates (> 1000 Hz), and simultaneously detecting a large range of flow...

  13. Differentially Private Support Vector Machines

    CERN Document Server

    Sarwate, Anand; Monteleoni, Claire

    2009-01-01

    This paper addresses the problem of practical privacy-preserving machine learning: how to detect patterns in massive, real-world databases of sensitive personal information, while maintaining the privacy of individuals. Chaudhuri and Monteleoni (2008) recently provided privacy-preserving techniques for learning linear separators via regularized logistic regression. With the goal of handling large databases that may not be linearly separable, we provide privacy-preserving support vector machine algorithms. We address general challenges left open by past work, such as how to release a kernel classifier without releasing any of the training data, and how to tune algorithm parameters in a privacy-preserving manner. We provide general, efficient algorithms for linear and nonlinear kernel SVMs, which guarantee $\\epsilon$-differential privacy, a very strong privacy definition due to Dwork et al. (2006). We also provide learning generalization guarantees. Empirical evaluations reveal promising performance on real and...

  14. Hybridity in Disgrace

    Institute of Scientific and Technical Information of China (English)

    刘建平

    2015-01-01

    John Maxwell Coetzee's masterpiece-Disgrace is the representative work about post colonialism.The novel describes a series of disgraceful events happened between the white and the black in the post apartheid South Africa.The famous literature theory-hybridity of Homi K.Bhabha is the very key theory to analyze the work.In post apartheid South Africa,hybridity is the only way for the white and the black to coexist.

  15. Hybrid Baryon Signatures

    CERN Document Server

    Page, P R

    2000-01-01

    We discuss whether a low-lying hybrid baryon should be defined as a three quark - gluon bound state or as three quarks moving on an excited adiabatic potential. We show that the latter definition becomes exact, not only for very heavy quarks, but also for specific dynamics. We review the literature on the signatures of hybrid baryons, with specific reference to strong hadronic decays, electromagnetic couplings, diffractive production and production in psi decay.

  16. Hybrid vertical cavity laser

    DEFF Research Database (Denmark)

    Chung, Il-Sug; Mørk, Jesper

    2010-01-01

    A new hybrid vertical cavity laser structure for silicon photonics is suggested and numerically investigated. It incorporates a silicon subwavelength grating as a mirror and a lateral output coupler to a silicon ridge waveguide.......A new hybrid vertical cavity laser structure for silicon photonics is suggested and numerically investigated. It incorporates a silicon subwavelength grating as a mirror and a lateral output coupler to a silicon ridge waveguide....

  17. Requirements for Hybrid Cosimulation

    Science.gov (United States)

    2014-08-16

    hybrid cosimulation version of the Functional Mockup Interface (FMI) standard. A cosimulation standard de nes interfaces that enable diverse simulation...cosimulation standards, and specifically provides guidance for development of a hybrid cosimulation version of the Functional Mockup Interface (FMI) standard...V. Peetz, and S. Wolf. The functional mockup interface for tool independent exchange of simulation models. In Proc. of the 8-th International

  18. Introduction to Vector Field Visualization

    Science.gov (United States)

    Kao, David; Shen, Han-Wei

    2010-01-01

    Vector field visualization techniques are essential to help us understand the complex dynamics of flow fields. These can be found in a wide range of applications such as study of flows around an aircraft, the blood flow in our heart chambers, ocean circulation models, and severe weather predictions. The vector fields from these various applications can be visually depicted using a number of techniques such as particle traces and advecting textures. In this tutorial, we present several fundamental algorithms in flow visualization including particle integration, particle tracking in time-dependent flows, and seeding strategies. For flows near surfaces, a wide variety of synthetic texture-based algorithms have been developed to depict near-body flow features. The most common approach is based on the Line Integral Convolution (LIC) algorithm. There also exist extensions of LIC to support more flexible texture generations for 3D flow data. This tutorial reviews these algorithms. Tensor fields are found in several real-world applications and also require the aid of visualization to help users understand their data sets. Examples where one can find tensor fields include mechanics to see how material respond to external forces, civil engineering and geomechanics of roads and bridges, and the study of neural pathway via diffusion tensor imaging. This tutorial will provide an overview of the different tensor field visualization techniques, discuss basic tensor decompositions, and go into detail on glyph based methods, deformation based methods, and streamline based methods. Practical examples will be used when presenting the methods; and applications from some case studies will be used as part of the motivation.

  19. Streamline Integration using MPI-Hybrid Parallelism on a Large Multi-Core Architecture

    Energy Technology Data Exchange (ETDEWEB)

    Camp, David; Garth, Christoph; Childs, Hank; Pugmire, Dave; Joy, Kenneth I.

    2010-11-01

    Streamline computation in a very large vector field data set represents a significant challenge due to the non-local and datadependentnature of streamline integration. In this paper, we conduct a study of the performance characteristics of hybrid parallel programmingand execution as applied to streamline integration on a large, multicore platform. With multi-core processors now prevalent in clustersand supercomputers, there is a need to understand the impact of these hybrid systems in order to make the best implementation choice.We use two MPI-based distribution approaches based on established parallelization paradigms, parallelize-over-seeds and parallelize-overblocks,and present a novel MPI-hybrid algorithm for each approach to compute streamlines. Our findings indicate that the work sharing betweencores in the proposed MPI-hybrid parallel implementation results in much improved performance and consumes less communication andI/O bandwidth than a traditional, non-hybrid distributed implementation.

  20. Vector optimization set-valued and variational analysis

    CERN Document Server

    Chen, Guang-ya; Yang, Xiaogi

    2005-01-01

    This book is devoted to vector or multiple criteria approaches in optimization. Topics covered include: vector optimization, vector variational inequalities, vector variational principles, vector minmax inequalities and vector equilibrium problems. In particular, problems with variable ordering relations and set-valued mappings are treated. The nonlinear scalarization method is extensively used throughout the book to deal with various vector-related problems. The results presented are original and should be interesting to researchers and graduates in applied mathematics and operations research

  1. Wavelet neural networks initialization using hybridized clustering and harmony search algorithm: Application in epileptic seizure detection

    Science.gov (United States)

    Zainuddin, Zarita; Lai, Kee Huong; Ong, Pauline

    2013-04-01

    Artificial neural networks (ANNs) are powerful mathematical models that are used to solve complex real world problems. Wavelet neural networks (WNNs), which were developed based on the wavelet theory, are a variant of ANNs. During the training phase of WNNs, several parameters need to be initialized; including the type of wavelet activation functions, translation vectors, and dilation parameter. The conventional k-means and fuzzy c-means clustering algorithms have been used to select the translation vectors. However, the solution vectors might get trapped at local minima. In this regard, the evolutionary harmony search algorithm, which is capable of searching for near-optimum solution vectors, both locally and globally, is introduced to circumvent this problem. In this paper, the conventional k-means and fuzzy c-means clustering algorithms were hybridized with the metaheuristic harmony search algorithm. In addition to obtaining the estimation of the global minima accurately, these hybridized algorithms also offer more than one solution to a particular problem, since many possible solution vectors can be generated and stored in the harmony memory. To validate the robustness of the proposed WNNs, the real world problem of epileptic seizure detection was presented. The overall classification accuracy from the simulation showed that the hybridized metaheuristic algorithms outperformed the standard k-means and fuzzy c-means clustering algorithms.

  2. Vector Competence of Argentine Mosquitoes (Diptera: Culicidae) for West Nile virus (Flaviviridae: Flavivirus)

    Science.gov (United States)

    MICIELI, MARÍA V.; MATACCHIERO, AMY C.; MUTTIS, EVANGELINA; FONSECA, DINA M.; ALIOTA, MATTHEW T.; KRAMER, LAURA D.

    2014-01-01

    We examined the ability of Culex pipiens L. complex mosquitoes from Argentina to vector West Nile virus (WNV) to assess their role in the transmission of WNV in South America. Several egg rafts of Culex spp. were collected from different breeding sites in the suburbs of the city of La Plata, Argentina, and a subset of each progeny was scored with morphological and genetic species indicators. Surprisingly, we did not find Cx. pipiens form pipiens, but found evidence of genetic hybrids of Culex quinquefasciatus and Cx. pipiens f. molestus. We then used morphological traits to create two colonies predominantly composed of one of these two taxa, although some hybrids are likely to have been included in both. These colonies were used in vector competence studies using NY99 and WN02 genotype strains of WNV obtained in New York State. As controls, we also tested colonies of U.S. Cx. quinquefasciatus and Cx. pipiens f. molestus. Additional Culex larvae from three drainage ditches near the cities of La Plata and Berisso, Argentina, were identified by morphological and high-resolution molecular markers (microsatellites) as Cx. quinquefasciatus Say, Cx. pipiens form molestus, and hybrids. Results indicate that Argentinian Culex are competent but only moderately efficient vectors of WNV and are less susceptible to this virus than comparable U.S. mosquito strains. Studies of vertical transmission of NY99 virus by Cx. pipiens f. molestus hybrids from Argentina yielded a minimal filial infection rate of 1.19 from females feeding during their second and later bloodmeals. PMID:23926785

  3. Predicting invasion patterns in coastal ecosystems : relationship between vector strength and vector tempo

    NARCIS (Netherlands)

    Haydar, Deniz; Wolff, Wim J.

    2011-01-01

    Oyster transports are among the leading anthropogenic vectors of coastwise introduction of non-indigenous species. Using the oyster industry of the Netherlands as a model system, we investigated the relationship between vector strength (number of invasions) and vector tempo (magnitude and frequency

  4. CLASSIFICATION OF CUBIC PARAMETERIZED HOMOGENEOUS VECTOR FIELDS

    Institute of Scientific and Technical Information of China (English)

    Karnal H.Yasir; TANG Yun

    2002-01-01

    In this paper the cubic homogeneous parameterized vector fields are studied.The classification of the phase portrait near the critical point is presented. This classification is an extension of the result given by Takens to the cubic homogeneous parameterized vector fields with six parameters.

  5. CLASSIFICATION OF CUBIC PARAMETERIZED HOMOGENEOUS VECTOR FIELDS

    Institute of Scientific and Technical Information of China (English)

    KamalH.Yasir; TNAGYun

    2002-01-01

    In this paper the cubic homogeneous parameterized vector fields are studied.The classification of the phase portrait near the critical point is presented.This classification is an extension of the result given by takens to the cubic homogeneous parameterized vector fields with six parameters.

  6. 40 CFR 240.206 - Vectors.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Vectors. 240.206 Section 240.206 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.206 Vectors....

  7. A Survey on Distance Vector Routing Protocols

    CERN Document Server

    Tang, Linpeng

    2011-01-01

    In this paper we give a brief introduction to five different distance vector routing protocols (RIP, AODV, EIGRP, RIP-MTI and Babel) and give some of our thoughts on how to solve the count to infinity problem. Our focus is how distance vector routing protocols, based on limited information, can prevent routing loops and the count to infinity problem.

  8. Nonlinear dynamics of a vectored thrust aircraft

    DEFF Research Database (Denmark)

    Sørensen, C.B; Mosekilde, Erik

    1996-01-01

    With realistic relations for the aerodynamic coefficients, numerical simulations are applied to study the longitudional dynamics of a thrust vectored aircraft. As function of the thrust magnitude and the thrust vectoring angle the equilibrium state exhibits two saddle-node bifurcations and three...

  9. Chiral Corrections to Vector Meson Decay Constants

    CERN Document Server

    Bijnens, J; Talavera, P; Bijnens, Johan; Gosdzinsky, Peter; Talavera, Pere

    1998-01-01

    We calculate the leading quark mass corrections of order $m_q\\log(m_q)$, $m_q$ and $m_q^{3/2}$ to the vector meson decay constants within Heavy Vector Meson Chiral Perturbation Theory. We discuss the issue of electromagnetic gauge invariance and the heavy mass expansion. Reasonably good fits to the observed decay constants are obtained.

  10. Nonlinear dynamics of a vectored thrust aircraft

    DEFF Research Database (Denmark)

    Sørensen, C.B; Mosekilde, Erik

    1996-01-01

    With realistic relations for the aerodynamic coefficients, numerical simulations are applied to study the longitudional dynamics of a thrust vectored aircraft. As function of the thrust magnitude and the thrust vectoring angle the equilibrium state exhibits two saddle-node bifurcations and three ...

  11. Deep Support Vector Machines for Regression Problems

    NARCIS (Netherlands)

    Wiering, Marco; Schutten, Marten; Millea, Adrian; Meijster, Arnold; Schomaker, Lambertus

    2013-01-01

    In this paper we describe a novel extension of the support vector machine, called the deep support vector machine (DSVM). The original SVM has a single layer with kernel functions and is therefore a shallow model. The DSVM can use an arbitrary number of layers, in which lower-level layers contain su

  12. Application of Vectors to Relative Velocity

    Science.gov (United States)

    Tin-Lam, Toh

    2004-01-01

    The topic 'relative velocity' has recently been introduced into the Cambridge Ordinary Level Additional Mathematics syllabus under the application of Vectors. In this note, the results of relative velocity and the 'reduction to rest' technique of teaching relative velocity are derived mathematically from vector algebra, in the hope of providing…

  13. Articulated Multimedia Physics, Lesson 4, Vectors.

    Science.gov (United States)

    New York Inst. of Tech., Old Westbury.

    As the fourth lesson of the Articulated Multimedia Physics Course, instructional materials are presented in this study guide. The subject matter is concerned with displacements, speeds, scalers, vector sum, and vector analysis.The content is arranged in scrambled form, and the use of matrix transparencies is required for students to control their…

  14. Vector-Quantization using Information Theoretic Concepts

    DEFF Research Database (Denmark)

    Lehn-Schiøler, Tue; Hegde, Anant; Erdogmus, Deniz

    2005-01-01

    The process of representing a large data set with a smaller number of vectors in the best possible way, also known as vector quantization, has been intensively studied in the recent years. Very efficient algorithms like the Kohonen Self Organizing Map (SOM) and the Linde Buzo Gray (LBG) algorithm...

  15. Clustering Categories in Support Vector Machines

    DEFF Research Database (Denmark)

    Carrizosa, Emilio; Nogales-Gómez, Amaya; Morales, Dolores Romero

    2017-01-01

    The support vector machine (SVM) is a state-of-the-art method in supervised classification. In this paper the Cluster Support Vector Machine (CLSVM) methodology is proposed with the aim to increase the sparsity of the SVM classifier in the presence of categorical features, leading to a gain in in...

  16. Increasing the Efficacy of Oncolytic Adenovirus Vectors

    Directory of Open Access Journals (Sweden)

    William S. M. Wold

    2010-08-01

    Full Text Available Oncolytic adenovirus (Ad vectors present a new modality to treat cancer. These vectors attack tumors via replicating in and killing cancer cells. Upon completion of the vector replication cycle, the infected tumor cell lyses and releases progeny virions that are capable of infecting neighboring tumor cells. Repeated cycles of vector replication and cell lysis can destroy the tumor. Numerous Ad vectors have been generated and tested, some of them reaching human clinical trials. In 2005, the first oncolytic Ad was approved for the treatment of head-and-neck cancer by the Chinese FDA. Oncolytic Ads have been proven to be safe, with no serious adverse effects reported even when high doses of the vector were injected intravenously. The vectors demonstrated modest anti-tumor effect when applied as a single agent; their efficacy improved when they were combined with another modality. The efficacy of oncolytic Ads can be improved using various approaches, including vector design, delivery techniques, and ancillary treatment, which will be discussed in this review.

  17. Vector Spaces of Non-measurable Functions

    Institute of Scientific and Technical Information of China (English)

    Francisco J. GARC(I)A-PACHECO; Juan B. SEOANE-SEP(U)LVEDA

    2006-01-01

    We show that there exists an infinite dimensional vector space every non-zero element of which is a non-measurable function. Moreover, this vector space can be chosen to be closed and to have dimensionβ for any cardinalityβ. Some techniques involving measure theory and density characters of Banach spaces are used.

  18. Diffeomorphism Invariant Theories and Vector Supersymmetry

    CERN Document Server

    Piguet, O

    2000-01-01

    Einstein gravity in the Palatini first order formalism is shown to possess a vector supersymmetry of the type encountered in the topological gauge theories. A peculiar feature of the gravitationel theory is the link of this vector supersymmetry with the field equation of motion of the Faddeev-Popov ghost associated to diffeomorphism invariance.

  19. Deep Support Vector Machines for Regression Problems

    NARCIS (Netherlands)

    Wiering, Marco; Schutten, Marten; Millea, Adrian; Meijster, Arnold; Schomaker, Lambertus

    2013-01-01

    In this paper we describe a novel extension of the support vector machine, called the deep support vector machine (DSVM). The original SVM has a single layer with kernel functions and is therefore a shallow model. The DSVM can use an arbitrary number of layers, in which lower-level layers contain

  20. Clifford Fourier transform on vector fields.

    Science.gov (United States)

    Ebling, Julia; Scheuermann, Gerik

    2005-01-01

    Image processing and computer vision have robust methods for feature extraction and the computation of derivatives of scalar fields. Furthermore, interpolation and the effects of applying a filter can be analyzed in detail and can be advantages when applying these methods to vector fields to obtain a solid theoretical basis for feature extraction. We recently introduced the Clifford convolution, which is an extension of the classical convolution on scalar fields and provides a unified notation for the convolution of scalar and vector fields. It has attractive geometric properties that allow pattern matching on vector fields. In image processing, the convolution and the Fourier transform operators are closely related by the convolution theorem and, in this paper, we extend the Fourier transform to include general elements of Clifford Algebra, called multivectors, including scalars and vectors. The resulting convolution and derivative theorems are extensions of those for convolution and the Fourier transform on scalar fields. The Clifford Fourier transform allows a frequency analysis of vector fields and the behavior of vector-valued filters. In frequency space, vectors are transformed into general multivectors of the Clifford Algebra. Many basic vector-valued patterns, such as source, sink, saddle points, and potential vortices, can be described by a few multivectors in frequency space.

  1. Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells.

    Science.gov (United States)

    Maeda, Mitsuko; Kida, Shinya; Hojo, Keiko; Eto, Yusuke; Gaob, Jian-Qing; Kurachi, Shinnosuke; Sekiguchi, Fumiko; Mizuguchi, Hiroyuki; Hayakawa, Takao; Mayumi, Tadanori; Nakagawa, Shinsaku; Kawasaki, Koichi

    2005-02-01

    The adenovirus vector is a promising carrier for the efficient transfer of genes into cells via the coxackie-adenovirus receptor (CAR) and integrins (alphavbeta3 and alphavbeta5). The clinical use of the adenovirus vector remains problematic however. Successful administration of this vector is associated with side effects because antibodies to this vector are commonly found throughout the human body. To make the adenovirus vector practicable for clinical use, it is necessary to design an auxiliary transporter. The present study describes the use of Arg-Gly-Asp(RGD)-related peptide, a peptide that binds to integrins, as an auxiliary transporter to aid efficient transport of adenovirus vector. Furthermore, poly(ethylene glycol) (PEG) was also used as a tool to modify the adenovirus such that the risk of side effects incurred during clinical application was reduced. The present study describes the design, preparation and use of (acetyl-Tyr-Gly-Gly-Arg-Gly-Asp-Thr-Pro-(beta)Ala)(2)Lys-PEG-(beta)Ala-Cys-NH(2)[(Ac-YGGRGDTP(beta)A)(2)K-PEG-(beta)AC] as an efficient peptide-PEG transporter tool for carrying adenovirus vector into cells. (Ac-YGGRGDTP(beta)A)(2)K-PEG-(beta)AC was coupled with 6-maleimidohexanoic acid N-hydroxysuccinimide ester and the resulting 6-[(Ac-YGGRGDTP(beta)A)(2)K-PEG-(beta)AC-succinimido]hexanoic acid N-hydroxysuccinimide ester reacted with adenovirus. The modified adenovirus with the peptide-PEG hybrid exhibited high gene expression even in a CAR-negative cell line, DC2.4.

  2. Combinatorial Hybrid Systems

    DEFF Research Database (Denmark)

    Larsen, Jesper Abildgaard; Wisniewski, Rafal; Grunnet, Jacob Deleuran

    2008-01-01

    As initially suggested by E. Sontag, it is possible to approximate an arbitrary nonlinear system by a set of piecewise linear systems. In this work we concentrate on how to control a system given by a set of piecewise linear systems defined on simplices. By using the results of L. Habets and J. van...... Schuppen, it is possible to find a controller for the system on each of the simplices thus guaranteeing that the system flow on the simplex only will leave the simplex through a subset of its faces. Motivated by R. Forman, on the triangulated state space we define a combinatorial vector field, which...... indicates for a given face the future simplex. In the suggested definition we allow nondeterminacy in form of splitting and merging of solution trajectories. The combinatorial vector field gives rise to combinatorial counterparts of most concepts from dynamical systems, such as duals to vector fields, flow...

  3. A Hybrid Security Situation Prediction Model for Information Network Based on Support Vector Machine and Particle Swarm Optimization%基于支持向量机和粒子群算法的信息网络安全态势复合预测模型

    Institute of Scientific and Technical Information of China (English)

    高昆仑; 刘建明; 徐茹枝; 王宇飞; 李怡康

    2011-01-01

    提出一种基于支持向量机和粒子群算法的网络态势复合预测模型.模型使用滑动窗口方法将各原始离散时间监测点的安全态势值构造成部分线性相关的连续时间序列,以其作为安全态势数据样本集对支持向量机加以训练,生成预测模型.在支持向量机训练过程中,利用粒子群算法搜寻支持向量机的最优训练参数,以降低支持向量机参数选择的盲目性,提高预测精度.最后通过基于大量电力企业信息网络现场安全监测数据的实验,验证了复合预测模型的有效性.%A security situation prediction model for information network based on support vector machine (SVM) and particle swarm optimization (PSO) is proposed. By use of sliding window, in the proposed model a continuous time series that is partially linearly dependent is constructed by security situation values sampled from original discrete time monitoring points, and taking the time series as the sample set of security situation data the SVM is trained to generate a prediction model. During the training of SVM, the PSO algorithm is used to search for the optimal training parameters of SVM to reduce the blindness in the selection of SVM parameters and improve precision of prediction.Through the experiments based on on-site installation and monitoring data of a lot of power enterprise information networks, the effectiveness of the proposed security situation prediction model is verified.

  4. Cascade Support Vector Machines with Dimensionality Reduction

    Directory of Open Access Journals (Sweden)

    Oliver Kramer

    2015-01-01

    Full Text Available Cascade support vector machines have been introduced as extension of classic support vector machines that allow a fast training on large data sets. In this work, we combine cascade support vector machines with dimensionality reduction based preprocessing. The cascade principle allows fast learning based on the division of the training set into subsets and the union of cascade learning results based on support vectors in each cascade level. The combination with dimensionality reduction as preprocessing results in a significant speedup, often without loss of classifier accuracies, while considering the high-dimensional pendants of the low-dimensional support vectors in each new cascade level. We analyze and compare various instantiations of dimensionality reduction preprocessing and cascade SVMs with principal component analysis, locally linear embedding, and isometric mapping. The experimental analysis on various artificial and real-world benchmark problems includes various cascade specific parameters like intermediate training set sizes and dimensionalities.

  5. Low-amplitude vector screening solitons

    Institute of Scientific and Technical Information of China (English)

    Keqing Lu(卢克清); Xiangping Zhu(朱香平); Wei Zhao(赵卫); Yanlong Yang(杨延龙); Jinping Li(李金萍); Yanpeng Zhang(张彦鹏); Junchang Zhang(张君昌)

    2004-01-01

    We show self-coupled and cross-coupled vector beam evolution equations in the low-amplitude regime for screening solitons,which can exhibit the analytical solutions of bright-bright and dark-dark vector solitons.Our analysis indicates that these self-coupled vector solitons are obtained irrespective of the intensities of the two optical beams,whereas these cross-coupled vector solitons can be established when the intensities of the two optical beams are equal.Relevant examples are provided where the photorefractive crystal is lithium niobate(LiNbO3).The stability properties of these vector solitons have been investigated numerically and it has been found that they are stable.

  6. Vector Diffusion Maps and the Connection Laplacian

    CERN Document Server

    Singer, Amit

    2011-01-01

    We introduce {\\em vector diffusion maps} (VDM), a new mathematical framework for organizing and analyzing massive high dimensional data sets, images and shapes. VDM is a mathematical and algorithmic generalization of diffusion maps and other non-linear dimensionality reduction methods, such as LLE, ISOMAP and Laplacian eigenmaps. While existing methods are either directly or indirectly related to the heat kernel for functions over the data, VDM is based on the heat kernel for vector fields. VDM provides tools for organizing complex data sets, embedding them in a low dimensional space, and interpolating and regressing vector fields over the data. In particular, it equips the data with a metric, which we refer to as the {\\em vector diffusion distance}. In the manifold learning setup, where the data set is distributed on (or near) a low dimensional manifold $\\MM^d$ embedded in $\\RR^{p}$, we prove the relation between VDM and the connection-Laplacian operator for vector fields over the manifold.

  7. Alphavirus vectors for cancer gene therapy (review).

    Science.gov (United States)

    Yamanaka, Ryuya

    2004-04-01

    Alphaviruses have several characteristics that make them attractive as gene therapy vectors such as transient and high-level expression of a heterologous gene. Alphavirus vectors, Semliki Forest virus (SFV), Sindbis virus (SIN) and Venezuelan equine encephalitis virus (VEE) have been developed as gene expression vectors. Alphaviruses are positive-strand RNA viruses that can mediate efficient cytoplasmic gene expression in mammalian cells. The alphavirus RNA replication machinery has been engineered for high level heterologous gene expression. Since an RNA virus vector cannot integrate into chromosomal DNA, concerns about cell transformation are reduced. Alphavirus vectors demonstrate promise for the safe tumor-killing and tumor-specific immune responses. Recombinant alphavirus RNA replicons may facilitate gene therapy of cancer.

  8. Axial Vector $Z'$ and Anomaly Cancellation

    CERN Document Server

    Ismail, Ahmed; Tsao, Kuo-Hsing; Unwin, James

    2016-01-01

    Whilst the prospect of new $Z'$ gauge bosons with only axial couplings to the Standard Model (SM) fermions is widely discussed, examples of anomaly-free renormalisable models are lacking in the literature. We look to remedy this by constructing several motivated examples. Specifically, we consider axial vectors which couple universally to all SM fermions, as well as those which are generation-specific, leptophilic, and leptophobic. Anomaly cancellation typically requires the presence of new coloured and charged chiral fermions, and we argue that the masses of these new states must generally be comparable to that of the axial vector. Finally, an axial vector mediator could provide a portal between SM and hidden sector states, and we also consider the possibility that the axial vector couples to dark matter. If the dark matter relic density is set due to freeze-out via the axial vector, this strongly constrains the parameter space.

  9. Axial vector Z‧ and anomaly cancellation

    Science.gov (United States)

    Ismail, Ahmed; Keung, Wai-Yee; Tsao, Kuo-Hsing; Unwin, James

    2017-05-01

    Whilst the prospect of new Z‧ gauge bosons with only axial couplings to the Standard Model (SM) fermions is widely discussed, examples of anomaly-free renormalisable models are lacking in the literature. We look to remedy this by constructing several motivated examples. Specifically, we consider axial vectors which couple universally to all SM fermions, as well as those which are generation-specific, leptophilic, and leptophobic. Anomaly cancellation typically requires the presence of new coloured and charged chiral fermions, and we argue that in a large class of models masses of these new states are expected to be comparable to that of the axial vector. Finally, an axial vector mediator could provide a portal between SM and hidden sector states, and we also consider the possibility that the axial vector couples to dark matter. If the dark matter relic density is set due to freeze-out via the axial vector, this strongly constrains the parameter space.

  10. Gauge vectors and double beta decay

    Science.gov (United States)

    Fonseca, Renato M.; Hirsch, Martin

    2017-02-01

    We discuss contributions to neutrinoless double beta (0 ν β β ) decay involving vector bosons. The starting point is a list of all possible vector representations that may contribute to 0 ν β β decay via d =9 or d =11 operators at tree level. We then identify gauge groups which contain these vectors in the adjoint representation. Even though the complete list of vector fields that can contribute to 0 ν β β up to d =11 is large (a total of 46 vectors), only a few of them can be gauge bosons of phenomenologically realistic groups. These latter cases are discussed in some more detail, and lower (upper) limits on gauge boson masses (mixing angles) are derived from the absence of 0 ν β β decay.

  11. Two-solar-mass hybrid stars: a two model description with the Nambu-Jona-Lasinio quark model

    CERN Document Server

    Pereira, Renan Câmara; Providência, Constança

    2016-01-01

    Hybrid stars with a quark phase described by the Nambu$-$Jona-Lasinio model are studied. The hadron-quark model used to determine the stellar matter equation of state favors the appearance of quark matter: the coincidence of the deconfinement and chiral transitions and a low vacuum constituent quark mass. These two properties are essential to build equations of state that predict pure quark matter in the center of neutron stars. The effect of vector-isoscalar and vector-isovector terms is discussed, and it is shown that the vector-isoscalar terms are necessary to describe 2$M_\\odot$ hybrid stars, and the vector-isovector terms result in larger quark cores and a smaller deconfinement density.

  12. Geoacoustic inversion using the vector field

    Science.gov (United States)

    Crocker, Steven E.

    The main goal of this project was to study the use of the acoustic vector field, separately or in combination with the scalar field, to estimate the depth dependent geoacoustic properties of the seafloor via non-linear inversion. The study was performed in the context of the Sediment Acoustics Experiment 2004 (SAX04) conducted in the Northern Gulf of Mexico (GOM) where a small number of acoustic vector sensors were deployed in close proximity to the seafloor. A variety of acoustic waveforms were transmitted into the seafloor at normal incidence. The acoustic vector sensors were located both above and beneath the seafloor interface where they measured the acoustic pressure and the acoustic particle acceleration. Motion data provided by the buried vector sensors were affected by a suspension response that was sensitive to the mass properties of the sensor, the sediment density and sediment elasticity (e.g., shear wave speed). The suspension response for the buried vector sensors included a resonance within the analysis band of 0.4 to 2.0 kHz. The suspension resonance represented an unknown complex transfer function between the acoustic vector field in the seabed and data representing that field. Therefore, inverse methods developed for this study were required to 1) estimate dynamic properties of the sensor suspension resonance and 2) account for the associated corruption of vector field data. A method to account for the vector sensor suspense response function was integrated directly into the inversion methods such that vector channel data corruption was reduced and an estimate of the shear wave speed in the sediment was returned. Inversions of real and synthetic data sets indicated that information about sediment shear wave speed was carried by the suspension response of the buried sensors, as opposed to being contained inherently within the acoustic vector field.

  13. The Hybrids of Postmodernism

    Directory of Open Access Journals (Sweden)

    Dana BĂDULESCU

    2014-09-01

    Full Text Available Hybridization is a fundamental characteristic of postmodernism, included by Ihab Hassan in his “catena” of features. This paper looks into the hybrids of postmodernism, which are the result of migration, displacement and uprooting, the re-visitation of myths, folklore and legends, or projections of their author’s imagination. The hybrids used as examples here are drawn from several novels written by Salman Rushdie, especially The Satanic Verses, two short stories, one by Márquez and the other by Donald Barthelme, Borges’s Book of Imaginary Beings, Cărtărescu’s Encyclopaedia of Dragons and Michelle Cliff’s No Telephone to Heaven. Diverse as they may be, these hybrids emphasize a defining characteristic of postmodernism, which is its pluralism. I conclude that the hybrids of postmodernism are aesthetically or politically subversive. Besides, what makes them difficult to grasp is their unfixed and protean nature. They ask for high leaps of the imagination, a total suspension of disbelief and a complete surrender to the powerful seduction of imagination on the reader’s part.

  14. Bottleneck Accumulation of Hybrid Magnetoelastic Bosons

    Science.gov (United States)

    Bozhko, Dmytro A.; Clausen, Peter; Melkov, Gennadii A.; L'vov, Victor S.; Pomyalov, Anna; Vasyuchka, Vitaliy I.; Chumak, Andrii V.; Hillebrands, Burkard; Serga, Alexander A.

    2017-06-01

    An ensemble of magnons, quanta of spin waves, can be prepared as a Bose gas of weakly interacting quasiparticles. Furthermore, the thermalization of the overpopulated magnon gas through magnon-magnon scattering processes, which conserve the number of particles, can lead to the formation of a Bose-Einstein condensate at the bottom of a spin-wave spectrum. However, magnon-phonon scattering can significantly modify this scenario and new quasiparticles are formed—magnetoelastic bosons. Our observations of a parametrically populated magnon gas in a single-crystal film of yttrium iron garnet by means of wave-vector-resolved Brillouin light scattering spectroscopy evidence a novel condensation phenomenon: A spontaneous accumulation of hybrid magnetoelastic bosonic quasiparticles at the intersection of the lowest magnon mode and a transversal acoustic wave.

  15. Active-flux based motion sensorless vector control of biaxial excitation generator/motor for automobiles (BEGA)

    DEFF Research Database (Denmark)

    Coroban-Schramel, Vasile; Boldea, Ion; Andreescu, Gheorghe-Daniel

    2009-01-01

    This paper proposes a novel, active-flux based, motion-sensorless vector control structure for biaxial excitation generator for automobiles (BEGA) for wide speed range operation. BEGA is a hybrid excited synchronous machine having permanent magnets on q-axis and a dc excitation on daxis. Using...... the active-flux concept the estimated rotor position is given by the sum of the active flux angle and torque angle. The active flux is calculated by subtracting the term Lq i s from the estimated stator flux vector. The experimental results validate the active flux-principle and show good performance...

  16. Research on Hybrid Vehicle Drivetrain

    Science.gov (United States)

    Xie, Zhongzhi

    Hybrid cars as a solution to energy saving, emission reduction measures, have received widespread attention. Motor drive system as an important part of the hybrid vehicles as an important object of study. Based on the hybrid electric vehicle powertrain control system for permanent magnet synchronous motor as the object of study. Can be applied to hybrid car compares the characteristics of traction motors, chose permanent magnet synchronous Motors as drive motors for hybrid vehicles. Building applications in hybrid cars in MATLAB/Simulink simulation model of permanent-magnet synchronous motor speed control system and analysis of simulation results.

  17. Hybrid Disease Diagnosis Using Multiobjective Optimization with Evolutionary Parameter Optimization

    Directory of Open Access Journals (Sweden)

    MadhuSudana Rao Nalluri

    2017-01-01

    Full Text Available With the widespread adoption of e-Healthcare and telemedicine applications, accurate, intelligent disease diagnosis systems have been profoundly coveted. In recent years, numerous individual machine learning-based classifiers have been proposed and tested, and the fact that a single classifier cannot effectively classify and diagnose all diseases has been almost accorded with. This has seen a number of recent research attempts to arrive at a consensus using ensemble classification techniques. In this paper, a hybrid system is proposed to diagnose ailments using optimizing individual classifier parameters for two classifier techniques, namely, support vector machine (SVM and multilayer perceptron (MLP technique. We employ three recent evolutionary algorithms to optimize the parameters of the classifiers above, leading to six alternative hybrid disease diagnosis systems, also referred to as hybrid intelligent systems (HISs. Multiple objectives, namely, prediction accuracy, sensitivity, and specificity, have been considered to assess the efficacy of the proposed hybrid systems with existing ones. The proposed model is evaluated on 11 benchmark datasets, and the obtained results demonstrate that our proposed hybrid diagnosis systems perform better in terms of disease prediction accuracy, sensitivity, and specificity. Pertinent statistical tests were carried out to substantiate the efficacy of the obtained results.

  18. Image Coding Based on Address Vector Quantization.

    Science.gov (United States)

    Feng, Yushu

    Image coding is finding increased application in teleconferencing, archiving, and remote sensing. This thesis investigates the potential of Vector Quantization (VQ), a relatively new source coding technique, for compression of monochromatic and color images. Extensions of the Vector Quantization technique to the Address Vector Quantization method have been investigated. In Vector Quantization, the image data to be encoded are first processed to yield a set of vectors. A codeword from the codebook which best matches the input image vector is then selected. Compression is achieved by replacing the image vector with the index of the code-word which produced the best match, the index is sent to the channel. Reconstruction of the image is done by using a table lookup technique, where the label is simply used as an address for a table containing the representative vectors. A code-book of representative vectors (codewords) is generated using an iterative clustering algorithm such as K-means, or the generalized Lloyd algorithm. A review of different Vector Quantization techniques are given in chapter 1. Chapter 2 gives an overview of codebook design methods including the Kohonen neural network to design codebook. During the encoding process, the correlation of the address is considered and Address Vector Quantization is developed for color image and monochrome image coding. Address VQ which includes static and dynamic processes is introduced in chapter 3. In order to overcome the problems in Hierarchical VQ, Multi-layer Address Vector Quantization is proposed in chapter 4. This approach gives the same performance as that of the normal VQ scheme but the bit rate is about 1/2 to 1/3 as that of the normal VQ method. In chapter 5, a Dynamic Finite State VQ based on a probability transition matrix to select the best subcodebook to encode the image is developed. In chapter 6, a new adaptive vector quantization scheme, suitable for color video coding, called "A Self -Organizing

  19. Fitness consequences of Anopheles gambiae population hybridization

    Directory of Open Access Journals (Sweden)

    Beier John C

    2005-09-01

    Full Text Available Abstract Background The use of transgenic mosquitoes with parasite inhibiting genes has been proposed as an integral strategy to control malaria transmission. However, release of exotic transgenic mosquitoes will bring in novel alleles along with parasite-inhibiting genes that may have unknown effects on native populations. Thus it is necessary to study the effects and dynamics of fitness traits in native mosquito populations in response to the introduction of novel genes. This study was designed to evaluate the dynamics of fitness traits in a simulation of introduction of novel alleles under laboratory conditions using two strains of Anopheles gambiae: Mbita strain from western Kenya and Ifakara strain from Tanzania. Methods The dynamics of fitness traits were evaluated under laboratory conditions using the two An. gambiae strains. These two geographically different strains were cross-bred and monitored for 20 generations to score fecundity, body size, blood-meal size, larval survival, and adult longevity, all of which are important determinants of the vector's potential in malaria transmission. Traits were analysed using pair-wise analysis of variance (ANOVA for fecundity, body size, and blood-meal size while survival analysis was performed for larval survival and adult longevity. Results Fecundity and body size were significantly higher in the progeny up to the 20th generation compared to founder strains. Adult longevity had a significantly higher mean up to the 10th generation and average blood-meal size was significantly larger up to the 5th generation, indicating that hybrids fitness is enhanced over that of the founder strains. Conclusion Hybridization of the two mosquito populations used in this study led to increased performance in the fitness traits studied. Given that the studied traits are important determinants of the vector's potential to transmit malaria, these results suggest the need to release genetically modified mosquitoes

  20. for hybrid dynamical systems

    Directory of Open Access Journals (Sweden)

    Wassim M. Haddad

    2001-01-01

    Full Text Available In this paper we develop a unified dynamical systems framework for a general class of systems possessing left-continuous flows; that is, left-continuous dynamical systems. These systems are shown to generalize virtually all existing notions of dynamical systems and include hybrid, impulsive, and switching dynamical systems as special cases. Furthermore, we generalize dissipativity, passivity, and nonexpansivity theory to left-continuous dynamical systems. Specifically, the classical concepts of system storage functions and supply rates are extended to left-continuous dynamical systems providing a generalized hybrid system energy interpretation in terms of stored energy, dissipated energy over the continuous-time dynamics, and dissipated energy over the resetting events. Finally, the generalized dissipativity notions are used to develop general stability criteria for feedback interconnections of left-continuous dynamical systems. These results generalize the positivity and small gain theorems to the case of left-continuous, hybrid, and impulsive dynamical systems.

  1. Hybrid Action Systems

    DEFF Research Database (Denmark)

    Rönnkö, M.; Ravn, Anders Peter; Sere, K.

    2003-01-01

    In this paper we investigate the use of action systems with differential actions in the specifcation of hybrid systems. As the main contribution we generalize the definition of a differential action, allowing the use of arbitrary relations over model variables and their time-derivatives in modell......In this paper we investigate the use of action systems with differential actions in the specifcation of hybrid systems. As the main contribution we generalize the definition of a differential action, allowing the use of arbitrary relations over model variables and their time...... parallel composition. Moreover, as the strength of the action system formalism is the support for stepwise development by refinement, we investigate refinement involving a differential action. We show that, due to the predicate transformer semantics, standard action refinement techniques apply also...... to the differential action, thus, allowing stepwise development of hybrid systems Udgivelsesdato: JAN 1...

  2. Conditional Hybrid Nonclassicality

    Science.gov (United States)

    Agudelo, E.; Sperling, J.; Costanzo, L. S.; Bellini, M.; Zavatta, A.; Vogel, W.

    2017-09-01

    We derive and implement a general method to characterize the nonclassicality in compound discrete- and continuous-variable systems. For this purpose, we introduce the operational notion of conditional hybrid nonclassicality which relates to the ability to produce a nonclassical continuous-variable state by projecting onto a general superposition of discrete-variable subsystem. We discuss the importance of this form of quantumness in connection with interfaces for quantum communication. To verify the conditional hybrid nonclassicality, a matrix version of a nonclassicality quasiprobability is derived and its sampling approach is formulated. We experimentally generate an entangled, hybrid Schrödinger cat state, using a coherent photon-addition process acting on two temporal modes, and we directly sample its nonclassicality quasiprobability matrix. The introduced conditional quantum effects are certified with high statistical significance.

  3. Porosity in hybrid materials

    Energy Technology Data Exchange (ETDEWEB)

    Schaefer, D.W.; Beaucage, G.; Loy, D. [Sandia National Labs., Albuquerque, NM (United States)

    1995-12-31

    Multicomponent, or hybrid composites are emerging as precursors to porous materials. Sacrifice of an ephemeral phase can be used to generate porosity, the nature of which depends on precursor structure. Retention of an organic constituent, on the other hand, can add desirable toughness to an otherwise brittle ceramic. We use small-angle x-ray and neutron scattering to examine porosity in both simple and hybrid materials. We find that microphase separation controls porosity in almost all systems studied. Pore distributions are controlled by the detailed bonding within and between phases as well as the flexibility of polymeric constituents. Thus hybridization opens new regions of pore distributions not available in simple systems. We look at several sacrificial concepts and show that it is possible to generate multimodal pore size distributions due to the complicated phase structure in the precursor.

  4. Photoproduction of Hybrid Mesons

    CERN Document Server

    Barnes, T

    1998-01-01

    In this contribution I discuss prospects for photoproducing hybrid mesons at CEBAF, based on recent model results and experimental indications of possible hybrids. One excellent opportunity appears to be a search for the I=1, JPC=2+-, neutral "(b2)o" hybrid in (a2 pi)o through diffractive photoproduction. Other notable possibilities accessible through pi+ or pio exchange photoproduction are I=1, JPC=1-+, charged "pi1+" in f1 pi+, (b1 pi)+ and (rho pi)+; piJ(1770)+ in f2 pi+ and (b1 pi)+; pi(1800)+ in f0 pi+, f2 pi+, omega rho+ and (rho pi)+; a1 in f1 pi+ and f2 pi+; and omega in (rho pi)o, omega eta and (K1 K)o.

  5. Smart hybrid rotary damper

    Science.gov (United States)

    Yang, C. S. Walter; DesRoches, Reginald

    2014-03-01

    This paper develops a smart hybrid rotary damper using a re-centering smart shape memory alloy (SMA) material as well as conventional energy-dissipating metallic plates that are easy to be replaced. The ends of the SMA and steel plates are inserted in the hinge. When the damper rotates, all the plates bend, providing energy dissipating and recentering characteristics. Such smart hybrid rotary dampers can be installed in structures to mitigate structural responses and to re-center automatically. The damaged energy-dissipating plates can be easily replaced promptly after an external excitation, reducing repair time and costs. An OpenSEES model of a smart hybrid rotary was established and calibrated to reproduce the realistic behavior measured from a full-scale experimental test. Furthermore, the seismic performance of a 3-story moment resisting model building with smart hybrid rotary dampers designed for downtown Los Angeles was also evaluated in the OpenSEES structural analysis software. Such a smart moment resisting frame exhibits perfect residual roof displacement, 0.006", extremely smaller than 18.04" for the conventional moment resisting frame subjected to a 2500 year return period ground motion for the downtown LA area (an amplified factor of 1.15 on Kobe earthquake). The smart hybrid rotary dampers are also applied into an eccentric braced steel frame, which combines a moment frame system and a bracing system. The results illustrate that adding smart hybrid rotaries in this braced system not only completely restores the building after an external excitation, but also significantly reduces peak interstory drifts.

  6. Analog and hybrid computing

    CERN Document Server

    Hyndman, D E

    2013-01-01

    Analog and Hybrid Computing focuses on the operations of analog and hybrid computers. The book first outlines the history of computing devices that influenced the creation of analog and digital computers. The types of problems to be solved on computers, computing systems, and digital computers are discussed. The text looks at the theory and operation of electronic analog computers, including linear and non-linear computing units and use of analog computers as operational amplifiers. The monograph examines the preparation of problems to be deciphered on computers. Flow diagrams, methods of ampl

  7. Hybrid Weyl semimetal

    Science.gov (United States)

    Li, Fei-Ye; Luo, Xi; Dai, Xi; Yu, Yue; Zhang, Fan; Chen, Gang

    2016-09-01

    We construct a tight-binding model realizing one pair of Weyl nodes and three distinct Weyl semimetals. In the type-I (type-II) Weyl semimetal, both nodes belong to type-I (type-II) Weyl nodes. In addition, there exists a third type, previously undiscovered and dubbed "hybrid Weyl semimetal", in which one Weyl node is of type I while the other is of type II. For the hybrid Weyl semimetal, we further demonstrate the bulk Fermi surfaces and the topologically protected surface states, analyze the unique Landau-level structure and quantum oscillation, and discuss the conditions for possible material realization.

  8. Toyota hybrid synergy drive

    Energy Technology Data Exchange (ETDEWEB)

    Gautschi, H.

    2008-07-01

    This presentation made at the Swiss 2008 research conference on traffic by Hannes Gautschi, director of service and training at the Toyota company in Switzerland, takes a look at Toyota's hybrid drive vehicles. The construction of the vehicles and their combined combustion engines and electric generators and drives is presented and the combined operation of these components is described. Braking and energy recovery are discussed. Figures on the performance, fuel consumption and CO{sub 2} output of the hybrid vehicles are compared with those of conventional vehicles.

  9. Toyota hybrid synergy drive

    Energy Technology Data Exchange (ETDEWEB)

    Gautschi, H.

    2008-07-01

    This presentation made at the Swiss 2008 research conference on traffic by Hannes Gautschi, director of service and training at the Toyota company in Switzerland, takes a look at Toyota's hybrid drive vehicles. The construction of the vehicles and their combined combustion engines and electric generators and drives is presented and the combined operation of these components is described. Braking and energy recovery are discussed. Figures on the performance, fuel consumption and CO{sub 2} output of the hybrid vehicles are compared with those of conventional vehicles.

  10. THERMALLY CLEAVABLE HYBRID MATERIALS

    Directory of Open Access Journals (Sweden)

    Constantin Gaina

    2011-12-01

    Full Text Available Thermally cleavable hybrid materials were prepared by the Diels-Alder cycloaddition reaction of poly(vinyl furfural to N phenylmaleimido-N’-(triethoxysilylpropylurea followed by the sol-gel condensation reaction of trietoxysilyl groups with water and acetic acid. Thermal and dynamic mechanical analysis, dielectric and FTIR spectroscopy were used to characterize the structure and properties of the composites. The size of the inorganic silica particles in the hybrid material varied dependent on the silica content. The DSC study of the prepared materials revealed that the cleavage process of the formed cycloadducts takes place at temperatures varying between 143-165°C and is an endothermic process.

  11. The hybrid BCI

    Directory of Open Access Journals (Sweden)

    Gert Pfurtscheller

    2010-04-01

    Full Text Available Nowadays, everybody knows what a hybrid car is. A hybrid car normally has 2 engines, its main purpose being to enhance energy efficiency and reduce CO2 output. Similarly, a typical hybrid brain-computer interface (BCI is also composed of 2 BCIs or at least one BCI and another system. Such a hybrid BCI, like any BCI, must fulfil the following four criteria: (i the device must rely on signals recorded directly from the brain; (ii there must be at least one recordable brain signal that the user can intentionally modulate to effect goal-directed behaviour; (iii real time processing; and (iv the user must obtain feedback. This paper introduces some hybrid BCIs which have already been published or are currently in development or validation, and some concepts for future work. The BCIs described classify 2 EEG patterns: One is the event-related (desynchronisation (ERD, ERS of sensorimotor rhythms, and the other is the steady-state visual evoked potential (SSVEP. The hybrid BCI can either have more than one input whereby the inputs are typically processed simultaneously or operate 2 systems sequentially, whereby the first system can act as a “brain switch”. In the case of self-paced operation of a SSVEP-based hand orthosis control with an motor imagery-based switch it was possible to reduce the rate of false positives during resting periods by about 50% compared to the SSVEP BCI alone. It is shown that such a brain switch can also rely on hemodynamic changes measured through near-infrared spectroscopy (NIRS. Another interesting approach is a hybrid BCI with simultaneous operations of ERD- and SSVEP-based BCIs. Here it is important to prove the existing promising offline simulation results with online experiments. Hybrid BCIs can also use one brain signal and another input. Such an additional input can be a physiological signal like the heart rate but also a signal from an external device like, an eye gaze control system.

  12. Retroviral Vector Biosafety: Lessons from Sheep

    Directory of Open Access Journals (Sweden)

    Van den Broeke Anne

    2003-01-01

    Full Text Available The safety of retroviral-based systems and the possible transmission of replication-competent virus to patients is a major concern associated with using retroviral vectors for gene therapy. While much effort has been put into the design of safe retroviral production methods and effective in vitro monitoring assays, there is little data evaluating the risks resulting from retroviral vector instability at post-transduction stages especially following in vivo gene delivery. Here, we briefly describe and discuss our observations in an in vivo experimental model based on the inoculation of retroviral vector-transduced tumor cells in sheep. Our data indicates that the in vivo generation of mosaic viruses is a dynamic process and that virus variants, generated by retroviral vector-mediated recombination, may be stored and persist in infected individuals prior to selection at the level of replication. Recombination may not only restore essential viral functions or provide selective advantages in a changing environment but also reestablish or enhance the pathogenic potential of the particular virus undergoing recombination. These observations in sheep break new ground in our understanding of how retroviral vectors may have an impact on the course of a preestablished disease or reactivate dormant or endogenous viruses. The in vivo aspects of vector stability raise important biosafety issues for the future development of safe retroviral vector-based gene therapy.

  13. The Representation of a Broadband Vector Field

    Institute of Scientific and Technical Information of China (English)

    Qunyan Ren; Jean Pierre Hermand; Shengchun Piao

    2011-01-01

    Compared to a scalar pressure sensor,a vector sensor can provide a higher signal-to-noise ratio (SNR)signal and more detailed information on the sound field.Study on vector sensors and their applications have become a hot topic.Research on the representation of a vector field is highly relevant for extending the scope of vector sensor technology.This paper discusses the range-frequency distribution of the vector field due to a broadband acoustic source moving in a shallow-water waveguide as the self noise of a surface ship,and the vector extension of the waveguide impulse response measured over a limited frequency range using an active source of known waveform.From theory analysis and numerical simulation,the range-frequency representation of a vector field exhibits an interference structure qualitatively similar to that of the corresponding pressure field but,being quantitatively different,provides additional information on the waveguide,especially through the vertical component.For the range-frequency representation,physical quantities that can better exhibit the interference characteristics of the waveguide are the products of pressure and particle velocity and of the pressure and pressure gradient.An image processing method to effectively detect and isolate the individual striations from an interference structure was reviewed briefly.The representation of the vector impulse response was discussed according to two different measurement systems,also known as particle velocity and pressure gradient.The vector impulse response representation can not only provide additional information from pressure only but even more than that of the range-frequency representation.

  14. Efficient than a Nonlentiviral Vector

    Directory of Open Access Journals (Sweden)

    Tao Yang

    2010-01-01

    Full Text Available Background. Lentiviral constructs reportedly can integrate into the genome of non-dividing, terminally differentiated cells and dividing cells, for long-term gene expression. This investigation tested whether a third generation lentiviral-mediated small interfering RNA (siRNA delivered into renal epithelial and fibroblast cells against type II transforming growth factor-beta receptor (siRNA-TBRII could better attenuate renal fibrogenesis in comparison with a non-lentiviral construct. Methods. HIV-derived lentiviral and non-lentiviral constructs were used to transfect cells with siRNA-TBRII or siRNA-EGFP control. Human embryonic kidney (HEK-293T, renal epithelial cells (NRK-52E and renal fibroblasts (NRK-49F were transfected and gene silencing quantified (fluorescence microscopy, Western blotting, fluorescence-activated cell sorting. Renal fibrogenesis was assessed using extracellular matrix protein synthesis (fibronectin and collagen-III; Western immunoblot, and α-smooth muscle actin (α-SMA was analysed as a marker of fibroblast activation and epithelial-to-mesenchymal transdifferentiation (EMT. Results. Lentiviral-mediated siRNA-TBRII significantly suppressed TBRII expression in all cell lines, and also significantly suppressed renal fibrogenesis. In comparison with the non-lentiviral construct, lentiviral-mediated siRNA-TBRII produced stronger and more persistent inhibition of collagen-III in NRK-49F cells, fibronectin in all renal cell lines, and α-SMA in renal epithelial cells. Conclusions. Lentiviral vector systems against TBRII can be delivered into renal cells to efficiently limit renal fibrogenesis by sequence-specific gene silencing.

  15. New Anomaly of the Axial-Vector Current

    Institute of Scientific and Technical Information of China (English)

    HE Han-Xin

    2001-01-01

    By computing the axial-vector current operator equation, we find the anomalous axial-vector curl equation besides the well-known anomalous axial-vector divergence equation (the Adler-Bell-Jackiw anomaly) and discuss its implication.``

  16. 600-GHz Electronically Tunable Vector Measurement System

    Science.gov (United States)

    Dengler, Robert; Maiwald, Frank; Siegel, Peter

    2007-01-01

    A compact, high-dynamic-range, electronically tunable vector measurement system that operates in the frequency range from approximately 560 to approximately 635 GHz has been developed as a prototype of vector measurement systems that would be suitable for use in nearly-real-time active submillimeter-wave imaging. As used here, 'vector measurement system" signifies an instrumentation system that applies a radio-frequency (RF) excitation to an object of interest and measures the resulting amplitude and phase response, relative to either the applied excitatory signal or another reference signal related in a known way to applied excitatory signal.

  17. Robust Pseudo-Hierarchical Support Vector Clustering

    DEFF Research Database (Denmark)

    Hansen, Michael Sass; Sjöstrand, Karl; Olafsdóttir, Hildur

    2007-01-01

    Support vector clustering (SVC) has proven an efficient algorithm for clustering of noisy and high-dimensional data sets, with applications within many fields of research. An inherent problem, however, has been setting the parameters of the SVC algorithm. Using the recent emergence of a method...... for calculating the entire regularization path of the support vector domain description, we propose a fast method for robust pseudo-hierarchical support vector clustering (HSVC). The method is demonstrated to work well on generated data, as well as for detecting ischemic segments from multidimensional myocardial...

  18. Nonlinear singular vectors and nonlinear singular values

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A novel concept of nonlinear singular vector and nonlinear singular value is introduced, which is a natural generalization of the classical linear singular vector and linear singular value to the nonlinear category. The optimization problem related to the determination of nonlinear singular vectors and singular values is formulated. The general idea of this approach is demonstrated by a simple two-dimensional quasigeostrophic model in the atmospheric and oceanic sciences. The advantage and its applications of the new method to the predictability, ensemble forecast and finite-time nonlinear instability are discussed. This paper makes a necessary preparation for further theoretical and numerical investigations.

  19. A NEW HYPERSPHERE SUPPORT VECTOR MACHINE ALGORITHM

    Institute of Scientific and Technical Information of China (English)

    Zhang Xinfeng; Shen Lansun

    2006-01-01

    The hypersphere support vector machine is a new algorithm in pattern recognition. By studying three kinds ofhypersphere support vector machines, it is found that their solutions are identical and the margin between two classes of samples is zero or is not unique. In this letter, a new kind ofhypersphere support vector machine is proposed. By introducing a parameter n(n>l), a unique solution of the margin can be obtained.Theoretical analysis and experimental results show that the proposed algorithm can achieve better generalization performance.

  20. Application of Genomics for Understanding Plant Virus-Insect Vector Interactions and Insect Vector Control.

    Science.gov (United States)

    Kaur, Navneet; Hasegawa, Daniel K; Ling, Kai-Shu; Wintermantel, William M

    2016-10-01

    The relationships between plant viruses and their vectors have evolved over the millennia, and yet, studies on viruses began virus and vector interactions even more recently. The advent of next generation sequencing, including rapid genome and transcriptome analysis, methods for evaluation of small RNAs, and the related disciplines of proteomics and metabolomics offer a significant shift in the ability to elucidate molecular mechanisms involved in virus infection and transmission by insect vectors. Genomic technologies offer an unprecedented opportunity to examine the response of insect vectors to the presence of ingested viruses through gene expression changes and altered biochemical pathways. This review focuses on the interactions between viruses and their whitefly or thrips vectors and on potential applications of genomics-driven control of the insect vectors. Recent studies have evaluated gene expression in vectors during feeding on plants infected with begomoviruses, criniviruses, and tospoviruses, which exhibit very different types of virus-vector interactions. These studies demonstrate the advantages of genomics and the potential complementary studies that rapidly advance our understanding of the biology of virus transmission by insect vectors and offer additional opportunities to design novel genetic strategies to manage insect vectors and the viruses they transmit.

  1. Mosquito vectors of dog heartworm in the United States: vector status and factors influencing transmission efficiency.

    Science.gov (United States)

    Ledesma, Nicholas; Harrington, Laura

    2011-11-01

    Dog heartworm (Dirofilaria immitis) is dependent on mosquito vectors for its maintenance and transmission among vertebrate hosts. Consequently, D. immitis abundance and distribution are closely linked with mosquito vector biology and ecology. Information on the important dog heartworm vectors in the United States is limited and no comprehensive surveillance of dog heartworm in US mosquitoes has been undertaken to date. Here, we review information gleaned from a number of field surveys documenting heartworm presence in wild mosquito populations as well as laboratory assessments of mosquito vector capacity. Various biological and ecological factors likely contribute to the relative importance of different vector species. We describe some of these factors, rank the leading criteria for efficient vectors, and present the most likely vector species found across the United States. Considering the recent emergence of drug resistance among D. immitis strains, practical knowledge of heartworm vector biology and control should be incorporated into heartworm disease management programs. We conclude by proposing that heartworm control would benefit by targeting mosquito vectors, and we suggest ways in which veterinarians can incorporate the recognition of vector importance into heartworm prevention recommendations imparted to clients. Copyright © 2011 Elsevier Inc. All rights reserved.

  2. Hybrid Ventilation Air Flow Process

    DEFF Research Database (Denmark)

    Heiselberg, Per Kvols

    The scope of this annex is therefore to obtain better knowledge of the use of hybrid ventilation technologies. The annex focus on development of control strategies for hybrid ventilation, on development of methods to predict hybrid ventilation performance in office buildings and on implementation...

  3. (Hybrid) Baryons Symmetries and Masses

    CERN Document Server

    Page, P R

    1999-01-01

    We construct (hybrid) baryons in the flux-tube model of Isgur and Paton. In the limit of adiabatic quark motion, we build proper eigenstates of orbital angular momentum and construct the flavour, spin and J^P of hybrid baryons from the symmetries of the system. The lowest mass hybrid baryon is estimated at approximately 2 GeV.

  4. Improved hybrid rocket fuel

    Science.gov (United States)

    Dean, David L.

    1995-01-01

    McDonnell Douglas Aerospace, as part of its Independent R&D, has initiated development of a clean burning, high performance hybrid fuel for consideration as an alternative to the solid rocket thrust augmentation currently utilized by American space launch systems including Atlas, Delta, Pegasus, Space Shuttle, and Titan. It could also be used in single stage to orbit or as the only propulsion system in a new launch vehicle. Compared to solid propellants based on aluminum and ammonium perchlorate, this fuel is more environmentally benign in that it totally eliminates hydrogen chloride and aluminum oxide by products, producing only water, hydrogen, nitrogen, carbon oxides, and trace amounts of nitrogen oxides. Compared to other hybrid fuel formulations under development, this fuel is cheaper, denser, and faster burning. The specific impulse of this fuel is comparable to other hybrid fuels and is between that of solids and liquids. The fuel also requires less oxygen than similar hybrid fuels to produce maximum specific impulse, thus reducing oxygen delivery system requirements.

  5. Workshop on hybrid rice

    Institute of Scientific and Technical Information of China (English)

    TANZhijun

    1994-01-01

    FAO, in collaboration with FEDEARROZ in Colombia and EMBRAPA / CNPAF in Brail, organized a workshop on the Establishment of a Coorperative Research Network on Hybrid Rice in Latin America and the Caribbean held from Mar 16 to 18, 1994 at EMBRAPA/CNPAF in Brazil. Dr MAO Changxiang,

  6. Teelt van hybride wintertarwerassen

    NARCIS (Netherlands)

    Timmer, R.D.; Paauw, J.G.M.

    2003-01-01

    Om de mogelijkheden van de teelt van hybride wintertarwerassen onder Nederlandse omstandigheden in beeld te brengen zijn er van 2000-2002 proeven uitgevoerd op het PPO-proefbedrijf te Lelystad. In deze proeven zijn een 4-tal hybriderassen (Hybnos, Hyno-braba, Hyno-esta, Mercury) vergeleken met een s

  7. Organics go hybrid

    Science.gov (United States)

    Lanzani, Guglielmo; Petrozza, Annamaria; Caironi, Mario

    2017-01-01

    From displays to solar cells, the field of organic optoelectronics has come a long way over the past 50 years, but the realization of an electrically pumped organic laser remains elusive. The answer may lie with hybrid organic-inorganic materials called perovskites.

  8. Hybrid-secure MPC 

    DEFF Research Database (Denmark)

    Lucas, Christoph; Raub, Dominik; Maurer, Ueli

    2010-01-01

    Most protocols for distributed, fault-tolerant computation, or multi-party computation (MPC), provide security guarantees in an all-or-nothing fashion. In contrast, a hybrid-secure protocol provides different security guarantees depending on the set of corrupted parties and the computational powe...

  9. Indexical Hybrid Tense Logic

    DEFF Research Database (Denmark)

    Blackburn, Patrick Rowan; Jørgensen, Klaus Frovin

    2012-01-01

    In this paper we explore the logic of now, yesterday, today and tomorrow by combining the semantic approach to indexicality pioneered by Hans Kamp [9] and refined by David Kaplan [10] with hybrid tense logic. We first introduce a special now nominal (our @now corresponds to Kamp’s original now...

  10. Nuclear hybrid energy infrastructure

    Energy Technology Data Exchange (ETDEWEB)

    Agarwal, Vivek; Tawfik, Magdy S.

    2015-02-01

    The nuclear hybrid energy concept is becoming a reality for the US energy infrastructure where combinations of the various potential energy sources (nuclear, wind, solar, biomass, and so on) are integrated in a hybrid energy system. This paper focuses on challenges facing a hybrid system with a Small Modular Reactor at its core. The core of the paper will discuss efforts required to develop supervisory control center that collects data, supports decision-making, and serves as an information hub for supervisory control center. Such a center will also be a model for integrating future technologies and controls. In addition, advanced operations research, thermal cycle analysis, energy conversion analysis, control engineering, and human factors engineering will be part of the supervisory control center. Nuclear hybrid energy infrastructure would allow operators to optimize the cost of energy production by providing appropriate means of integrating different energy sources. The data needs to be stored, processed, analyzed, trended, and projected at right time to right operator to integrate different energy sources.

  11. Hybrid printed electronics

    NARCIS (Netherlands)

    Koetse, M.; Smits, E.; Rubingh, E.; Teunissen, P.; Kusters, R.; Abbel, R.; Brand, J. van den

    2016-01-01

    Although many electronic functionalities can be realized by printed or organic electronics, short-term marketable products often require robust, reproducible, and nondisturbing technologies. In this chapter we show how hybrid electronics, a combination of printed circuitry, thin-film electronics,

  12. Hybrid keyword search auctions

    KAUST Repository

    Goel, Ashish

    2009-01-01

    Search auctions have become a dominant source of revenue generation on the Internet. Such auctions have typically used per-click bidding and pricing. We propose the use of hybrid auctions where an advertiser can make a per-impression as well as a per-click bid, and the auctioneer then chooses one of the two as the pricing mechanism. We assume that the advertiser and the auctioneer both have separate beliefs (called priors) on the click-probability of an advertisement. We first prove that the hybrid auction is truthful, assuming that the advertisers are risk-neutral. We then show that this auction is superior to the existing per-click auction in multiple ways: 1. We show that risk-seeking advertisers will choose only a per-impression bid whereas risk-averse advertisers will choose only a per-click bid, and argue that both kind of advertisers arise naturally. Hence, the ability to bid in a hybrid fashion is important to account for the risk characteristics of the advertisers. 2. For obscure keywords, the auctioneer is unlikely to have a very sharp prior on the click-probabilities. In such situations, we show that having the extra information from the advertisers in the form of a per-impression bid can result in significantly higher revenue. 3. An advertiser who believes that its click-probability is much higher than the auctioneer\\'s estimate can use per-impression bids to correct the auctioneer\\'s prior without incurring any extra cost. 4. The hybrid auction can allow the advertiser and auctioneer to implement complex dynamic programming strategies to deal with the uncertainty in the click-probability using the same basic auction. The per-click and per-impression bidding schemes can only be used to implement two extreme cases of these strategies. As Internet commerce matures, we need more sophisticated pricing models to exploit all the information held by each of the participants. We believe that hybrid auctions could be an important step in this direction. The

  13. Delivering Transgenic DNA Exceeding the Carrying Capacity of AAV Vectors.

    Science.gov (United States)

    Hirsch, Matthew L; Wolf, Sonya J; Samulski, R J

    2016-01-01

    Gene delivery using recombinant adeno-associated virus (rAAV) has emerged to the forefront demonstrating safe and effective phenotypic correction of diverse diseases including hemophilia B and Leber's congenital amaurosis. In addition to rAAV's high efficiency of transduction and the capacity for long-term transgene expression, the safety profile of rAAV remains unsoiled in humans with no deleterious vector-related consequences observed thus far. Despite these favorable attributes, rAAV vectors have a major disadvantage preventing widespread therapeutic applications; as the AAV capsid is the smallest described to date, it cannot package "large" genomes. Currently, the packaging capacity of rAAV has yet to be definitively defined but is approximately 5 kb, which has served as a limitation for large gene transfer. There are two main approaches that have been developed to overcome this limitation, split AAV vectors, and fragment AAV (fAAV) genome reassembly (Hirsch et al., Mol Ther 18(1):6-8, 2010). Split rAAV vector applications were developed based upon the finding that rAAV genomes naturally concatemerize in the cell post-transduction and are substrates for enhanced homologous recombination (HR) (Hirsch et al., Mol Ther 18(1):6-8, 2010; Duan et al., J Virol 73(1):161-169, 1999; Duan et al., J Virol 72(11):8568-8577, 1998; Duan et al., Mol Ther 4(4):383-391, 2001; Halbert et al., Nat Biotechnol 20(7):697-701, 2002). This method involves "splitting" the large transgene into two separate vectors and upon co-transduction, intracellular large gene reconstruction via vector genome concatemerization occurs via HR or nonhomologous end joining (NHEJ). Within the split rAAV approaches there currently exist three strategies: overlapping, trans-splicing, and hybrid trans-splicing (Duan et al., Mol Ther 4(4):383-391, 2001; Halbert et al., Nat Biotechnol 20(7):697-701, 2002; Ghosh et al., Mol Ther 16(1):124-130, 2008; Ghosh et al., Mol Ther 15(4):750-755, 2007). The other major

  14. Viruses vector control proposal: genus Aedes emphasis

    Directory of Open Access Journals (Sweden)

    Nelson Nogueira Reis

    Full Text Available Abstract The dengue fever is a major public health problem in the world. In Brazil, in 2015, there were 1,534,932 cases, being 20,320 cases of severe form, and 811 deaths related to this disease. The distribution of Aedes aegypti, the vector, is extensive. Recently, Zika and Chikungunya viruses had arisen, sharing the same vector as dengue and became a huge public health issue. Without specific treatment, it is urgently required as an effective vector control. This article is focused on reviewing vector control strategies, their effectiveness, viability and economical impact. Among all, the Sterile Insect Technique is highlighted as the best option to be adopted in Brazil, once it is largely effectively used in the USA and Mexico for plagues related to agribusiness.

  15. Weaving knotted vector fields with tunable helicity

    CERN Document Server

    Kedia, Hridesh; Dennis, Mark R; Irvine, William T M

    2016-01-01

    We present a general construction of divergence-free knotted vector fields from complex scalar fields, whose closed field lines encode many kinds of knots and links, including torus knots, their cables, the figure-8 knot and its generalizations. As finite-energy physical fields they represent initial states for fields such as the magnetic field in a plasma, or the vorticity field in a fluid. We give a systematic procedure for calculating the vector potential, starting from complex scalar functions with knotted zero filaments, thus enabling an explicit computation of the helicity of these knotted fields. The construction can be used to generate isolated knotted flux tubes, filled by knots encoded in the lines of the vector field. Lastly we give examples of manifestly knotted vector fields with vanishing helicity. Our results provide building blocks for analytical models and simulations alike.

  16. Low Power, Self Calibrated Vector Magnetometer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I SBIR project investigates a novel approach to vector magnetometry based on high precision measurements of the total magnetic field. The calibration is...

  17. Integrated epidemiology for vector-borne zoonoses.

    Science.gov (United States)

    Wardrop, Nicola A

    2016-02-01

    The development and application of interventions for the control of vector-borne zoonoses requires broad understanding of epidemiological linkages between vector, animal infection and human infection. However, there are significant gaps in our understanding of these linkages and a lack of appropriate data poses a considerable barrier to addressing this issue. A move towards strengthened surveillance of vectors and disease in both animal and human hosts, in combination with linked human-animal surveys, could form the backbone for epidemiological integration, enabling explicit assessment of the animal-human (and vector) interface, and subsequent implications for spill-over to human populations. Currently available data on the spatial distribution of human African trypanosomiasis allow an illustrative example.

  18. Sensorless vector and direct torque control

    CERN Document Server

    Vas, Peter

    1998-01-01

    This is the first comprehensive book on sensorless high performance a.c. drives. It is essential reading for anyone interested in acquiring a solid background on sensorless torque-controlled drives. It presents a detailed and unified treatment of sensorless vector-controlled and direct-torque controlled drive systems. It also discusses the applications of artificial intelligence to drives. Where possible, space vector theory is used and emphasis is laid on detailed mathematical and physical analysis. Sensorless drive schemes for different types of permanent magnet synchronous motors, synchronous reluctance motors, and induction motors are also presented. These include more than twenty vector drives e.g. five types of MRAS-based vector drives, and eleven types of direct-torque-controlled (DTC) drives, e.g. the ABB DTC drive. However, torque-controlled switched reluctance motor drives are also discussed due to their emerging importance. The book also covers various drive applications using artificial intellige...

  19. Generalized Stokes vector for three photon process

    CERN Document Server

    Shaji, Chitra; Satyanarayana, SVM; Sharan, Alok

    2015-01-01

    Stokes Muller formalism is important to understand the optical properties of materials by measuring the change in the polarization state of light upon scattering. The formalism can be extended to nonlinear scattering processes involving two and three photon processes. In this work, we derive a triple Stokes vector analytically using operator approach used in quantum theory of light. A three photon polarization state can be described by Stokes vector that has sixteen components involving cubes of intensities. The response of a material for the scattering of light in a three photon process is described by 4 x 16 Muller matrix. Polarization in Polarization out (PIPO) experiments can be carried out to determine the elements of Muller matrix. For that we identify 16 independent points in Poincare sphere and construct triple Stokes vector for each point. Four measurements to find the linear Stokes vector of the scattered light for incident light in each of the sixteen three photon states determine the Muller matrix...

  20. Gamow Vectors Explain the Shock "Batman" Profile

    CERN Document Server

    Braidotti, Maria Chiara; Conti, Claudio

    2016-01-01

    The description of shock waves beyond the shock point is a challenge in nonlinear physics. Finding solutions to the global dynamics of dispersive shock waves is not always possible due to the lack of integrability. Here we propose a new method based on the eigenstates (Gamow vectors) of a reversed harmonic oscillator in a rigged Hilbert space. These vectors allow analytical formulation for the development of undular bores of shock waves in a nonlinear nonlocal medium. Experiments by a photothermal induced nonlinearity confirm theoretical predictions: as the undulation period as a function of power and the characteristic quantized decays of Gamow vectors. Our results demonstrate that Gamow vector are a novel and effective paradigm for describing extreme nonlinear phenomena.