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Sample records for hwang woo suk

  1. Oversight framework over oocyte procurement for somatic cell nuclear transfer: comparative analysis of the Hwang Woo Suk case under South Korean bioethics law and U.S. guidelines for human embryonic stem cell research.

    Science.gov (United States)

    Kim, Mi-Kyung

    2009-01-01

    We examine whether the current regulatory regime instituted in South Korea and the United States would have prevented Hwang's potential transgressions in oocyte procurement for somatic cell nuclear transfer, we compare the general aspects and oversight framework of the Bioethics and Biosafety Act in South Korea and the US National Academies' Guidelines for Human Embryonic Stem Cell Research, and apply the relevant provisions and recommendations to each transgression. We conclude that the Act would institute centralized oversight under governmental auspices while the Guidelines recommend politically-independent, decentralized oversight bodies including a special review body for human embryonic stem cell research at an institutional level and that the Guidelines would have provided more vigorous protection for the women who had undergone oocyte procurement for Hwang's research than the Act. We also suggest additional regulations to protect those who provide oocytes for research in South Korea.

  2. Stem-cell spin: Covering the Hwang-affair in Science and Nature

    DEFF Research Database (Denmark)

    Kjærgaard, Rikke Schmidt

    2011-01-01

    In 2006 the South Korean cloning expert Woo Suk Hwang was found guilty of fraud and scientific misconduct. The scandal was reaching far beyond Hwang’s own laboratory encompassing national pride, geopolitics and regional discussions of stem-cell research. But the HIn 2006 the South Korean cloning...... expert Woo Suk Hwang was found guilty of fraud and scientific misconduct. The scandal reached far beyond Hwang’s own laboratory, encompassing national pride, geopolitics and global discussions of stem-cell research. But the Hwang affair was also a case of fierce competition between two of the world...

  3. WooCommerce cookbook

    CERN Document Server

    Rauland, Patrick

    2015-01-01

    If you have ever built or managed a WordPress site and want to add e-commerce functionality into your site, WooCommerce and this book are perfect for you. Learning how to use WooCommerce through this series of recipes will give you a solid platform to add any future e-commerce needs.

  4. An interview with Hyeon-Shik Hwang

    Directory of Open Access Journals (Sweden)

    Guilherme Thiesen

    2016-02-01

    Full Text Available It gives me great pleasure to interview Dr. Hyeon-Shik Hwang, an innovative orthodontist who has developed many creative techniques over his career. Dr. Hwang was born in Korea and received his DDS and PhD degrees from Yonsei University in Seoul. He is professor and chairman of the Department of Orthodontics at Chonnam National University School of Dentistry, Gwangju, Korea. Dr. Hwang, as a faculty at the university hospital, has maintained a successful clinical practice for more than 25 years. He has treated many adult patients focusing on esthetics and periodontal health and has developed many clinical techniques to improve the effectiveness and efficiency of treatment to the benefit of both the patient and practitioner. Dr. Hwang is also interested in the evaluation of facial asymmetry two- and three-dimensionally. As one of the early adopters of cone-beam volume imaging, he has given special emphasis on the management of surgical cases. He is married to Jung-Un Park with whom he has two sons. His favorite hobbies are photography and listening to music. When I was presented to him in a congress, it was a great pleasure meeting someone who I already admired for his singular work. Later on, his humbleness and knowledge made me marvel at him even more. I hope that all readers of Dental Press Journal of Orthodontics also enjoy the teachings from this brilliant Korean orthodontist! Guilherme Thiesen - interview coordinator

  5. An interview with Hyeon-Shik Hwang.

    Science.gov (United States)

    Hwang, Hyeon-Shik; Thiesen, Guilherme; Araújo, Telma Martins de; Freitas, Maria Perpétua Mota; Motta, Alexandre Trindade Simões da

    2016-01-01

    It gives me great pleasure to interview Dr. Hyeon-Shik Hwang, an innovative orthodontist who has developed many creative techniques over his career. Dr. Hwang was born in Korea and received his DDS and PhD degrees from Yonsei University in Seoul. He is professor and chairman of the Department of Orthodontics at Chonnam National University School of Dentistry, Gwangju, Korea. Dr. Hwang, as a faculty at the university hospital, has maintained a successful clinical practice for more than 25 years. He has treated many adult patients focusing on esthetics and periodontal health and has developed many clinical techniques to improve the effectiveness and efficiency of treatment to the benefit of both the patient and practitioner. Dr. Hwang is also interested in the evaluation of facial asymmetry two- and three-dimensionally. As one of the early adopters of cone-beam volume imaging, he has given special emphasis on the management of surgical cases. He is married to Jung-Un Park with whom he has two sons. His favorite hobbies are photography and listening to music. When I was presented to him in a congress, it was a great pleasure meeting someone who I already admired for his singular work. Later on, his humbleness and knowledge made me marvel at him even more. I hope that all readers of Dental Press Journal of Orthodontics also enjoy the teachings from this brilliant Korean orthodontist! Guilherme Thiesen - interview coordinator.

  6. Kloonimiskuningas osutus tüssajaks / Arko Olesk

    Index Scriptorium Estoniae

    Olesk, Arko, 1981-

    2006-01-01

    Lõuna-Korea teadlane Hwang Woo-Suk astus möödunud aasta lõpus pettuses süüdistatuna tagasi Souli ülikooli professori kohalt, olles varem alusetult väitnud, et on saavutanud läbimurde geenitehnoloogias ning suudab tõhusalt tüvirakke luua

  7. Kolm Armastust ja Anarhiat. Nekrofiil, drellimõrvar ja John Woo Tallinnas / Jaan Ruus

    Index Scriptorium Estoniae

    Ruus, Jaan, 1938-2017

    2009-01-01

    Helsingi filmifestivali "Armastus ja Anarhia" mitme seansi toimumisest Eestis 1993.a. septembris : Abel Ferrara "Drellimõrvar" ("Driller Killer", 1979), sakslase Jörg Buttgereiti "Nekromantik" (1987) ja "Nekromantik 2" (1991), John Woo "Hard Boiled" (1993). Buttgereit ja Woo olid ka ise kohal

  8. Improving the security of the Hwang-Su protocol for mobile networks

    African Journals Online (AJOL)

    user

    Improving the security of the Hwang-Su protocol for mobile networks. Miloud Ait ... But, it is threatened by weak ... Wireless networks (IEEE standard 802.11 1996, Gast 2005) have allowed computer systems to exchange data without cable.

  9. Ethical modernization: research misconduct and research ethics reforms in Korea following the Hwang affair.

    Science.gov (United States)

    Kim, Jongyoung; Park, Kibeom

    2013-06-01

    The Hwang affair, a dramatic and far reaching instance of scientific fraud, shocked the world. This collective national failure prompted various organizations in Korea, including universities, regulatory agencies, and research associations, to engage in self-criticism and research ethics reforms. This paper aims, first, to document and review research misconduct perpetrated by Hwang and members of his research team, with particular attention to the agencies that failed to regulate and then supervise Hwang's research. The paper then examines the research ethics reforms introduced in the wake of this international scandal. After reviewing American and European research governance structures and policies, policy makers developed a mixed model mindful of its Korean context. The third part of the paper examines how research ethics reform is proactive (a response to shocking scientific misconduct and ensuing external criticism from the press and society) as well as reactive (identification of and adherence to national or international ethics standards). The last part deals with Korean society's response to the Hwang affair, which had the effect of a moral atomic bomb and has led to broad ethical reform in Korean society. We conceptualize this change as ethical modernization, through which the Korean public corrects the failures of a growth-oriented economic model for social progress, and attempts to create a more trustworthy and ethical society.

  10. Improving the security of the Hwang-Su protocol for mobile networks

    African Journals Online (AJOL)

    user

    Improving the security of the Hwang-Su protocol for mobile networks. Miloud Ait Hemad, My ... Furthermore, the wireless data channel is low data rate. These restrictions have an ..... Research in Security and Privacy. Wu T. Y. and Tsen Y. M., ...

  11. Justification and Persuasion about Cloning: Arguments in Hwang's Paper and Journalistic Reported Versions

    Science.gov (United States)

    Jimenez-Aleixandre, Maria Pilar; Federico-Agraso, Marta

    2009-01-01

    We examine the argumentative structure of Hwang et al.'s (2004) paper about human somatic cell nuclear transfer (SCNT, or "therapeutic cloning"), contrasted with four Journalistic Reported Versions (JRV) of it, and with students' summaries of one JRV. As the evaluation of evidence is one of the critical features of argumentation…

  12. Improving the security of the Hwang-Su protocol for mobile networks ...

    African Journals Online (AJOL)

    The mobile networks are experiencing a growing success. This success is mainly due to the fact that these networks providing the mobility of users, the transmission of data through open air and the requirement of low power. But, it is threatened by weak security, especially at the level of authentication. Hwang and Su have ...

  13. Bioactive compounds fractionated from endophyte Streptomyces SUK 08 with promising ex-vivo antimalarial activity

    Directory of Open Access Journals (Sweden)

    Noraziah Mohamad Zin

    2017-12-01

    Full Text Available Objective: To determine ex vivo antimalarial activity and cytotoxicity of endophytic Streptomyces SUK 08 as well as the main core structure fractionated from its crude extract. Methods: The activities of SUK 08 crude extract were evaluated by using the Plasmodium lactate dehydrogenase assay and synchronization test against rodent malaria parasite Plasmodium berghei, instead of human malarial parasite Plasmodium falciparum. The cytotoxicity of the crude extract was determined by MTT assay. The crude extract was analyzed by thin-layer chromatography and gas chromatography–mass spectrophotometry. Results: The ethyl acetate crude extract showed very promising antimalarial activity with IC50 of 1.25 mg/mL. The synchronization tests showed that ethyl acetate extraction could inhibit all stages of the Plasmodium life cycle, but it was most effective at the Plasmodium ring stage. On the basis of a MTT assay on Chang Liver cells, ethyl acetate and ethanol demonstrated IC50 values of >1.0 mg/mL. The IC50 of parasitemia at 5% and 30% for this extract was lower than chloroquine. Thin-layer chromatography, with 1: 9 ratio of ethyl acetate: hexane, was used to isolate several distinct compounds. Based on gas chromatography–mass spectrophotometry analysis, three core structures were identified as cyclohexane, butyl propyl ester, and 2,3-heptanedione. Structurally, these compounds were similar to currently available antimalarial drugs. Conclusions: The results suggest that compounds isolated from Streptomyces SUK 08 are viable antimalarial drug candidates that require further investigations. Keywords: Butyl–propyl–ester, Cyclohexane, 2,3-Heptanedione, Endophyte, Streptomyces, Antimalarial

  14. Hexavalent chromate reduction during growth and by immobilized cells of arthrobacter sp. suk 1205

    International Nuclear Information System (INIS)

    Dey, S.; Paul, A.K.

    2017-01-01

    The chromate reducing actinomycetes, Arthrobacter sp. SUK 1205, isolated from chromite mine overburden of Odisha, India exhibited significant chromate reduction during growth with characteristic formation of pale green insoluble precipitate. Reduction of chromate increased with increase in inoculum density but the reduction potential declined as and when Cr(VI) concentration in the medium was increased. Chromate reducing efficiency was promoted when glycerol and glucose were used as electron donors and pH and temperature were maintained at 7.0 and 35 degree C, respectively. The reduction process was inhibited by several metal ions and metabolic inhibitors but not by Cu(II), Mn(II) and DNP. Among the matrices tested for whole cell immobilization, Ca-alginate immobilized whole cells were found to be most effective and were comparable with non-immobilized cells. Minimal salts (MS) medium was the most effective base for Cr(VI) reduction studies with immobilized cells. Under such conditions, the immobilized cells retained their enzymatic activity at least for 4 consecutive cycles indicating the potential of Arthrobacter sp. SUK 1205 in bioremediation of environmental chromium pollution. (author)

  15. Isolation, Purification, and Characterization of Five Active Diketopiperazine Derivatives from Endophytic Streptomyces SUK 25 with Antimicrobial and Cytotoxic Activities.

    Science.gov (United States)

    Alshaibani, Muhanna; Zin, Noraziah; Jalil, Juriyati; Sidik, Nik; Ahmad, Siti Junaidah; Kamal, Nurkhalida; Edrada-Ebel, Ruangelie

    2017-07-28

    In our search for new sources of bioactive secondary metabolites from Streptomyces sp., the ethyl acetate extracts from endophytic Streptomyces SUK 25 afforded five active diketopiperazine (DKP) compounds. The aim of this study was to characterize the bioactive compounds isolated from endophytic Streptomyces SUK 25 and evaluate their bioactivity against multiple drug resistance (MDR) bacteria such as Enterococcus raffinosus, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and Enterobacter spp., and their cytotoxic activities against the human hepatoma (HepaRG) cell line. The production of secondary metabolites by this strain was optimized through Thornton's medium. Isolation, purification, and identification of the bioactive compounds were carried out using high-performance liquid chromatography, high-resolution mass liquid chromatography-mass spectrometry, Fourier transform infrared spectroscopy, and nuclear magnetic resonance, and cryopreserved HepaRG cells were selected to test the cytotoxicity. The results showed that endophytic Streptomyces SUK 25 produces four active DKP compounds and an acetamide derivative, which were elucidated as cyclo -( L -Val- L -Pro), cyclo -( L -Leu- L -Pro), cyclo -( L -Phe- L -Pro), cyclo -( L -Val- L -Phe), and N -(7-hydroxy-6-methyl-octyl)-acetamide. These active compounds exhibited activity against methicillin-resistant S. aureus ATCC 43300 and Enterococcus raffinosus , with low toxicity against human hepatoma HepaRG cells. Endophytic Streptomyces SUK 25 has the ability to produce DKP derivatives biologically active against some MDR bacteria with relatively low toxicity against HepaRG cells line.

  16. Perceptions on climate change and its impact on livelihoods in Hwange district, Zimbabwe

    OpenAIRE

    Charles Nhemachena; Reneth Mano; Shakespear Mudombi; Virginia Muwanigwa

    2014-01-01

    This study investigated perceptions of rural communities on climate change and its impacts on livelihoods. The research was conducted in the semi-arid Hwange district in Matebelel and North province of Zimbabwe. The perceptions were compared with empirical evidence from climatic studies on trends on temperature and rainfall, and impacts on livelihoods in the country and region. The findings from the current study are generally in agreement with those of other studies that indicate changes in ...

  17. Optimization of cultural conditions for growth associated chromate reduction by Arthrobacter sp. SUK 1201 isolated from chromite mine overburden

    Energy Technology Data Exchange (ETDEWEB)

    Dey, Satarupa, E-mail: dey1919@gmail.com [Microbiology Laboratory, Department of Botany, University of Calcutta, Kolkata 700019 (India); Paul, A.K., E-mail: amalk_paul@yahoo.co.in [Microbiology Laboratory, Department of Botany, University of Calcutta, Kolkata 700019 (India)

    2012-04-30

    Highlights: Black-Right-Pointing-Pointer Isolation of a potent Cr(VI) resistant and reducing Arthrobacter SUK 1201 from chromite mine overburdens of Orissa, India. Black-Right-Pointing-Pointer Phylogenetically (16S rDNA analysis), Arthrobacter SUK 1201 showed 99% nucleotide base pair similarity with Arthrobacter GZK-1. Black-Right-Pointing-Pointer Production of insoluble chromium precipitates during chromate reduction under batch culture by the isolate SUK 1201. Black-Right-Pointing-Pointer Confirmation of formation of insoluble chromium precipitate during reduction studies by EDX analysis. Black-Right-Pointing-Pointer Optimization of cultural conditions for Cr(VI) reduction under batch culture leading to complete reduction of 2 mM of Cr(VI). - Abstract: Arthrobacter sp. SUK 1201, a chromium resistant and reducing bacterium having 99% sequence homology of 16S rDNA with Arthrobacter sp. GZK-1 was isolated from chromite mine overburden dumps of Orissa, India. The objective of the present study was to optimize the cultural conditions for chromate reduction by Arthrobacter sp. SUK 1201. The strain showed 67% reduction of 2 mM chromate in 7 days and was associated with the formation of green insoluble precipitate, which showed characteristic peak of chromium in to energy dispersive X-ray analysis. However, Fourier transform infrared spectra have failed to detect any complexation of end products of Cr(VI) reduction with the cell mass. Reduction of chromate increased with increased cell density and was maximum at 10{sup 10} cells/ml, but the reduction potential decreased with increase in Cr(VI) concentration. Chromate reducing efficiency was promoted when glycerol and glucose was used as electron donors. Optimum pH and temperature of Cr(VI) reduction was 7.0 and 35 Degree-Sign C respectively. The reduction process was inhibited by several metal ions and metabolic inhibitors but not by Cu(II) and DNP. These findings suggest that Arthrobacter sp. SUK 1201 has great promise

  18. Draft genome sequence of an endophytic bacterium, Paenibacillus tyrfis strain SUK123, isolated from Santiria apiculata stem

    Directory of Open Access Journals (Sweden)

    Emmanuel Haruna

    2017-12-01

    Full Text Available Here we report the draft genome sequence of an endophytic Paenibacillus tyrfis strain isolated from the Universiti Kebangsaan Malaysia reserve forest, Malaysia. The genome size was approximately 8.04 Mb, and the assembly consisted of 107 scaffolds with 168 contigs, and had a G + C content of 53%. Phylogenetic analysis of strain SUK123 using the 16S rRNA gene revealed that it belonged to the family Paenibacillaceae with the highest similarity to Paenibacillus elgii SDT (99%. Whole genome comparison of SUK123 with related species using average nucleotide identity (ANI analysis revealed a similarity of 98% to Paenibacillus tyrfis Mst1T, 94% to Paenibacillus elgii B69T, 91% to Paenibacillus ehimensis A2T, 68% to Paenibacillus polymyxa SC2T and 69% to Paenibacillus alvei DMS29T. The draft genome was deposited at the European Nucleotide Archive (PRJEB21373.

  19. Penerapan Strategi Pemasaran Pada UMKM Melalui Metode Analisis SWOT (Studi Pada Toko Pakaian Sukli Fashion di Pasar Petisah Medan)

    OpenAIRE

    Freddy

    2016-01-01

    Each business unit aims to maintain its viability and to develop, by maintaining and increasing the profit. These objectives can be achieved through marketing, by implementing marketing strategies by analyzing the internal and external factors of the company. The research was conducted at Sukli Fashion Clothing Store. Phenomenon is the slow progress of this shop business when business efforts have been made. The purpose of this study is to analyze the internal and external factors of comp...

  20. Wooing-Scenes in “Richard III”: A Parody of Courtliness?

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    Agnieszka Stępkowska

    2009-11-01

    Full Text Available In the famous opening soliloquy of Shakespeare’s Richard III, Richard mightily voices his repugnance to “fair well-spoken days” and their “idle pleasures”. He realizes his physical deformity and believes that it sets him apart from others. He openly admits that he is “not shaped for sportive tricks, nor made to court an amorous looking-glass”. Yet, his monstrosity constitutes more perhaps of his aggressive masculine exceptionality rather than of his deformity. Richard’s bullying masculinity manifests itself in his contempt for women. In the wooing scenes we clearly see his pugnacious pursuit of power over effeminate contentment by reducing women to mere objects. Additionally, those scenes are interesting from a psychological viewpoint as they brim over with conflicting emotions. Therefore, the paper explores two wooing encounters of the play, which belong the best examples of effective persuasion and also something we may refer to as ‘the power of eloquence’.

  1. Sedimentology, Sequence Stratigraphy and Reservoir Characterization of Samana Suk Formation Exposed in Namal Gorge Section, Salt Range, Mianwali, Punjab, Pakistan

    Directory of Open Access Journals (Sweden)

    Muhammad Hayat

    2016-06-01

    Full Text Available Samana Suk Formation of Bathonian-callovain age, exposed in Nammal Gorge Salt Range, has been studied for microfacies and sequence stratigraphic investigation. The formation is mainly composed of limestone, with minor beds of sandstone and marl. The limestone is grey, yellowish and purple in color. Limestone is fine grained, thin to medium bedded and inter-bedded with algal laminations. The sandstone is light yellowish brown, brick red in color, calcareous and quartzose. Within Samana Suk Formation one 2ndorder sequence and two 3rdorder sequences have been identified. Their regional correlation through fine-tuned dating helped to develop basin fill model and to understand facies dynamics. A facie belt comprising a wide belt of carbonate facies characterized by Peloidal Packstone microfacies represents inner ramp setting and Pelletal/ Peloidal Wackstone, Mud-Wackstone and Mudstone microfacies represent the low energy lagoonal environment. The sandstone lithofacies represents high energy beach environment which indicates aggrading to pro-grading pattern. The porosity analysis has been done on different samples of limestone and sandstone. For the porosity analysis the Image J software is used. In limestone the porosity ranges up to 6% while in sandstone the porosity ranging up to 18%. From the field and porosity analysis it is concluded that Samana Suk Formation in study area is good reservoir.

  2. Justification and Persuasion about Cloning: Arguments in Hwang's Paper and Journalistic Reported Versions

    Science.gov (United States)

    Jiménez-Aleixandre, María Pilar; Federico-Agraso, Marta

    2009-05-01

    We examine the argumentative structure of Hwang et al.’s (2004) paper about human somatic cell nuclear transfer (SCNT, or ‘therapeutic cloning’), contrasted with four Journalistic Reported Versions (JRV) of it, and with students’ summaries of one JRV. As the evaluation of evidence is one of the critical features of argumentation (Jiménez-Aleixandre 2008), the analysis focuses on the use of evidence, drawing from instruments to analyze written argumentation (Kelly et al. 2008) and from studies about the structure of empirical research reports (Swales 2001). The objectives are: 1) To examine the use of evidence and the argumentative structure of Hwang et al.’s Science, 303: 1669-1674 (2004) original paper in terms of the criteria: a) pertinence of the evidence presented to the claims; b) sufficiency of the evidence for the purpose of supporting the claims; and c) coordination of the evidence across epistemic levels. 2) To explore how the structure of Hwang’s paper translates into the JRV and into university students’ perceptions about the evidence supporting the claims. The argumentative structure of Hwang’s paper is such that its apparently ostensible main claim about NT constitutes a justification for a second claim about its therapeutic applications, for which no evidence is offered. However, this second claim receives prominent treatment in the JRV and in the students’ summaries. Implications for promoting critical reading in the classroom are discussed.

  3. Research ethics and lessons from Hwanggate: what can we learn from the Korean cloning fraud?

    Science.gov (United States)

    Saunders, R; Savulescu, J

    2008-03-01

    In this review of the Korean cloning scandal involving Woo-Suk Hwang, the nature of the disaster is documented and reasons why it occurred are suggested. The general problems it raises for scientific research are highlighted and six possible ways of improving practice are offered in the light of this case: (1) better education of science students; (2) independent monitoring and validation; (3) guidelines for tissue donation for research; (4) fostering of debate about ethically contentious research in science journals; (5) development of an international code of ethical research practice; (6) fostering of public involvement in ethical review and debate through the web.

  4. Research Misconduct—Definitions, Manifestations and Extent

    Directory of Open Access Journals (Sweden)

    Lutz Bornmann

    2013-10-01

    Full Text Available In recent years, the international scientific community has been rocked by a number of serious cases of research misconduct. In one of these, Woo Suk Hwang, a Korean stem cell researcher published two articles on research with ground-breaking results in Science in 2004 and 2005. Both articles were later revealed to be fakes. This paper provides an overview of what research misconduct is generally understood to be, its manifestations and the extent to which they are thought to exist.

  5. Spotted hyaenas Crocuta crocuta prey on new-born elephant calves in Hwange National Park, Zimbabwe

    Directory of Open Access Journals (Sweden)

    Julia Salnicki

    2001-07-01

    Full Text Available Spotted hyaena Crocuta crocuta are known to be opportunists and to have a varied diet including mammals, reptiles and birds. Prey most often hunted are medium sized ungulates but spotted hyaenas will on occasion take larger species such as giraffe Giraffa camelopardalis and zebra Equus burchellii. They are also known to hunt whichever species are most abundant and will vary their prey seasonally. In this study spotted hyaenas were observed to take an unusual prey species in the form of elephant calves (Loxodonta africana. On a number of occasions hyaenas were observed feeding on or killing newborn and very young elephant calves. These observations were made whilst the authors were conducting research on spotted hyaena ecology in the woodlands of Hwange National Park, Zimbabwe and were made during the dry season between September and November 1999.

  6. Effect of Herbal Acupuncture with Sang-hwang(Phellinus linteus on High Fat Diet-induced Obesity in Rats

    Directory of Open Access Journals (Sweden)

    Ji Hyun Kim

    2004-02-01

    Full Text Available Acupuncture has fairly good weight-reducing effect in treating simple obesity due to the neuroendocrine regulation. In this study, the anti-obesity effects of herbal acupuncture (HA with Sang-hwang (Phellinus linteus at Fuai (SP16 were investigated in the rat fed on high-fat (HF diet. Sang-hwang mushroom has been proven to have anti-carcinogenic effects and Sang-hwang extracts are highly effective in treatment and preventive treatment of AIDS, diabetes and high blood-pressure. To determine whether the Sang-hwang herbal acupuncture may have the anti-obesity effect, male Sprague-Dawley (4-wk-old rats were fed a HF diet for 5 wk, which produced significant weight gain compared to rats were fed a normal diet, and then herbal acupuncture were treated for 3 wk in HF diet group. The body weight, food consumption, food effeciency ratio (FER, body fat mass, plasma nitric oxide (NO were investigated in rats fed on normal diet, HF diet, and HF diet with HA (HF-diet-HA groups. NO has been proposed to be involved in the regulation of food intake. In addition, the expression of appetite peptides such as orexigenic peptide neuropeptide Y (NPY and the anorectic peptide cholecystokinin (CCK were observed in the hypothalamus. HF-HA group reduced body weight gain, FER, body fat contents and NO concentration compared to HF diet group. The expression of NPY was reduced in arcuate nucleus (ARC, and CCK was increased in the paraventricular nucleus (PVN after treatment of HA. In conclusion, Sang-hwang HA reduced adipocity, plasma NO and hypothalamic NPY, but increased CCK expression in the HF diet-induced obesity rat, therefore HA may have anti-obesity action through regulating body weight and appetite peptide of the central nervous system.

  7. Ecofriendly biodegradation and detoxification of Reactive Red 2 textile dye by newly isolated Pseudomonas sp. SUK1

    International Nuclear Information System (INIS)

    Kalyani, D.C.; Telke, A.A.; Dhanve, R.S.; Jadhav, J.P.

    2009-01-01

    The aim of this work is to evaluate textile dyes degradation by novel bacterial strain isolated from the waste disposal sites of local textile industries. Detailed taxonomic studies identified the organisms as Pseudomonas species and designated as strain Pseudomonas sp. SUK1. The isolate was able to decolorize sulfonated azo dye (Reactive Red 2) in a wide range (up to 5 g l -1 ), at temperature 30 deg. C, and pH range 6.2-7.5 in static condition. This isolate also showed decolorization of the media containing a mixture of dyes. Measurements of COD were done at regular intervals to have an idea of mineralization, showing 52% reduction in the COD within 24 h. Induction in the activity of lignin peroxidase and azoreductase was observed during decolorization of Reactive Red 2 in the batch culture, which represented their role in degradation. The biodegradation was monitored by UV-vis, IR spectroscopy, HPLC. The final product, 2-naphthol was characterized by GC-mass spectroscopy. The phytotoxicity study revealed the degradation of Reactive Red 2 into non-toxic product by Pseudomonas sp. SUK1

  8. Art as a Political Act: Expression of Cultural Identity, Self-Identity, and Gender by Suk Nam Yun and Yong Soon Min

    Science.gov (United States)

    Caruso, Hwa Young Choi

    2005-01-01

    This cross-cultural study explored the lives of two contemporary Korean/Korean American women artists--Suk Nam Yun and Yong Soon Min--who live in Seoul, South Korea, and Los Angeles, California. The author's research focused on the artists' identity formation, artistic expression, professional achievements, and the role of art as a political act.…

  9. Current meter components and other data from FIXED PLATFORMS from Yellow Sea (Hwang Hai) from 10 January 1986 to 30 June 1986 (NODC Accession 8800190)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Current meter components data were collected from FIXED PLATFORMS in the Yellow Sea (Hwang Hai) from 10 January 1986 to 30 June 1986. Data were collected by Florida...

  10. Perceptions on climate change and its impact on livelihoods in Hwange district, Zimbabwe

    Directory of Open Access Journals (Sweden)

    Charles Nhemachena

    2014-12-01

    Full Text Available This study investigated perceptions of rural communities on climate change and its impacts on livelihoods. The research was conducted in the semi-arid Hwange district in Matebelel and North province of Zimbabwe. The perceptions were compared with empirical evidence from climatic studies on trends on temperature and rainfall, and impacts on livelihoods in the country and region. The findings from the current study are generally in agreement with those of other studies that indicate changes in the climate, especially in terms of rainfall. This largely applies to short-term periods; however, for long-term periods it is difficult to accurately relate rural community perceptions to changes in rainfall over time. Despite perceived changes and impacts of climate change on local livelihood activities, mainly agriculture, there are multiple stressors that the communities face which also affect their livelihoods. Further evidence-based research is required to disentangle climate change impacts on livelihoods, including livelihood impacts arising from interactions of climate and non-climatic factors.

  11. For love or money? The saga of Korean women who provided eggs for embryonic stem cell research.

    Science.gov (United States)

    Baylis, Françoise

    2009-01-01

    In 2004 and 2005, Woo-Suk Hwang achieved international stardom with publications in Science reporting on successful research involving the creation of stem cells from cloned human embryos. The wonder and success all began to unravel, however, when serious ethical concerns were raised about the source of the eggs for this research. When the egg scandal had completely unfolded, it turned out that many of the women who provided eggs for stem cell research had not provided valid consents and that nearly 75% of the women egg providers had received cash or in-kind payments. Among those who did not receive direct benefits, some cited patriotism as their reason for participating in embryonic stem cell research, hence the question "for love or money?"--namely, patriotism versus payment. This paper summarizes the Hwang debacle with particular attention to the egg scandal and ends with some preliminary thoughts on patriotism as a motive for research participation.

  12. Isolation and characterization of cyclo-(tryptophanyl-prolyl and chloramphenicol from Streptomyces sp. SUK 25 with antimethicillin-resistant Staphylococcus aureus activity

    Directory of Open Access Journals (Sweden)

    Alshaibani MM

    2016-05-01

    Full Text Available Muhanna M Alshaibani,1 Juriyati Jalil,2 Nik M Sidik,3 Ruangelie Edrada-Ebel,4 Noraziah M Zin1 1Programme of Biomedical Science, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, 2Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, 3School of Bioscience and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Malaysia; 4Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland Background: Zingiber spectabile, commonly known as Beehive Ginger, is used as an ethnobotanical plant in many countries as an appetizer or to treat stomachache, toothache, muscle sprain, and as a cure for swelling, sores and cuts. This is the first report of isolation of Streptomyces strain from the root of this plant. Strain Universiti Kebangsaan 25 (SUK 25 has a very high activity to produce secondary metabolites against methicillin-resistant Staphylococcus aureus (MRSA, which is associated with high morbidity and mortality rates due to acquired multidrug resistance genes and causes medication failure in some clinical cases worldwide. Phylogenetic analysis based on the 16S ribosomal RNA gene sequence exhibited that the most closely related strain was Streptomyces omiyaensis NBRC 13449T (99.0% similarity. Aim: This study was conducted to carry out the extraction, identification, and biological evaluation of active metabolites isolated from SUK 25 against three MRSA strains, namely, MRSA ATCC 43300, MRSA ATCC 33591, and MRSA ATCC 49476. Materials and methods: The production of secondary metabolites by this strain was optimized through Thronton’s media. Isolation, purification, and identification of the bioactive compounds were carried out using reversed-phase high-performance liquid chromatography, high-resolution mass spectrometry, Fourier transform infrared, and one-dimensional and two-dimensional nuclear magnetic

  13. Wooing patients with technology.

    Science.gov (United States)

    Myers, Michael

    2013-04-01

    Technologies that can give healthcare organizations a marketing advantage with patients include: Registration kiosks that request payment automatically, in a more comfortable environment for both patients and registration staff. Emails that enable patients to schedule initial visits and follow-up care. Secure online messaging platforms that enable patients to obtain timely answers to questions they have for their providers both before and after receiving services.

  14. Temporal Vulnerability and the Post-Disaster ‘Window of Opportunity to Woo' : A Case Study of an African-American Floodplain Neighborhood after Hurricane Floyd in North Carolina

    NARCIS (Netherlands)

    de Vries, D.H.

    After major flooding associated with Hurricane Floyd (1999) in North Carolina, mitigation managers seized upon the “window of opportunity” to woo residents to accept residential buyout offers despite sizable community resistance. I present a theoretical explanation of how post-crisis periods turn

  15. Temporal Vulnerability and the Post-Disaster 'Window of Opportunity to Woo:' a Case Study of an African-American Floodplain Neighborhood after Hurricane Floyd in North Carolina.

    Science.gov (United States)

    de Vries, Daniel H

    2017-01-01

    After major flooding associated with Hurricane Floyd (1999) in North Carolina, mitigation managers seized upon the "window of opportunity" to woo residents to accept residential buyout offers despite sizable community resistance. I present a theoretical explanation of how post-crisis periods turn into "opportunities" based on a temporal referential theory that complements alternative explanations based on temporal coincidence, panarchy, and shock-doctrine theories. Results from fieldwork conducted from 2002 to 2004 illustrate how several temporal influences compromised collective calibration of "normalcy" in local cultural models, leading to an especially heightened vulnerability to collective surprise. Four factors particularly influenced this temporal vulnerability: 1) epistemological uncertainty of floodplain dynamics due to colonization; 2) cultural practices that maintained a casual amnesia; 3) meaning attributed to stochastic timing of floods; and 4) competitive impact of referential flood baseline attractors.

  16. The effect of Ga-mee-gwui-ryong-tang and Yuk-mee ji-hwang-tang Herbal-acupuncture on the growth of mice

    Directory of Open Access Journals (Sweden)

    Min-jung Kim

    2006-12-01

    Full Text Available Objectives : To investigate the effect of Ga-mee-Gwui-ryong-tang herbal acupuncture (GR-HA at GB39 and ST36 and the effect of Yuk-mee ji-hwang-tang herbal acupuncture (YM-HA at GB39 and KI10 on growth in mice. Methods : Mice were divided into 7 groups(n=10 ; saline-ST36, saline-GB39, saline-KI10, GR-HA-ST36 group treated with GR-HA at right ST36, GR-HA-GB39 group treated with GR-HA at right GB39, YM-HA-GB39 group treated with YM-HA at right GB39, YM-HA-KI10 group treated with YM-HA at right KI10. Saline-ST36 group, saline-GB39 group and saline-KI10 group were injected with saline at right ST36, GB39, KI10 respectively. Saline injection and HA were performed 3 times a week for 18 days. The length(total height, body length and tail length, weight and the protein efficiency ratio were measured as well as IGF-1 level in serum. Results : 1. GR-HA at GB39 and GR-HA at ST36 promoted growth in weight, tail length and total height but there was no statistical significance. 2. GR-HA at GB39 significantly promoted protein efficiency on the 14th day and GR-HA at ST36 on the 3rd day. 3. GR-HA at GB39 significantly increased serum IGF-1. GR-HA at ST36 increased IGF-1 slightly but with no statistical significance. 4. YM-HA at GB39 and YM-HA at KI10 promoted growth in weight, height, tail length and total height but there was no statistical relevance. 5. YM-HA at GB39 and YM-HA at KI10 significantly promoted protein efficiency on the 14th day. 6. YM-HA at GB39 and YM-HA at KI10 significantly increased serum IGF-1. Serum IGF-1 level of YM-HA-KI10 group was significantly higher than that of YM-HA-GB39 group. 7. Serum IGF-1 level of GR-HA-GB39 group was significantly higher than that of YM-HA-GB39 group. Conclusions : GR-HA and YM-HA both may promote growth. This study suggests that herbal acupuncture at GB39 is more effective with Gwui-ryong-tang than Yuk-mee ji-hwang-tang to promote growth. It also suggests that Yuk-mee ji-hwang-tang herbal acupuncture is more

  17. An Ecological Paradox: The African Wild Dog (Lycaon Pictus Is Not Attracted to Water Points When Water Is Scarce in Hwange National Park, Zimbabwe.

    Directory of Open Access Journals (Sweden)

    Henry Ndaimani

    Full Text Available In dry biomes, spatio-temporal variation in surface water resource stocks is pervasive, with unknown effects on the ranging behaviour of large predators. This study assessed the effect of spatial variation in surface water resources on the ranging behaviour of the African wild dog (Lycaon pictus. We analyzed data for 1992 (dry year with 20 water points and 2000 (wet year with 30 water points against presence-only data for five packs of L. pictus in a part of Hwange National Park and adjacent smallholder communal farming areas in western Zimbabwe. Modelling the potential habitat for L. pictus using Maxent with distance from water points (Dw and Normalized Difference Vegetation Index (NDVI as predictor variables was successful for 2000 (AUC = 0.793 but not successful for 1992 (AUC = 0.423, with L. pictus probability of occurrence near water points being more for year 2000 than for year 1992. The predicted L. pictus range was wider in 1992 (~13888.1 km2 than in 2000 (~958.4 km2 (Test of Proportions, χ2 = 124.52, df = 1, P = 0.00. Using the 2nd order Multitype Nearest Neighbour Distance Function (Gcross, we also observed significant attraction between L. pictus and water points within only ~1km radius for 1992 but up to ~8km radius for 2000. Our study reinforced the notion that surface water resources attract wild dogs in the savannahs but paradoxically less so when water resources are scarce. In particular, our study furthers current understanding of the effects of changing water availability regimes on the endangered L. pictus, providing evidence that the endangered predator's home range encroaches into potential ecological traps (i.e., smallholder communal farming areas when water resources are scarce.

  18. Overseas airlines woo Chinese tourists

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> A well-known ancient Chinese poet, Su Shi (1037-1101), used to describe the natural scene in April as: "Two or three sprays of peach behind bamboo; When spring warms the river the ducks are the first to know."As for the potential of China’s tourism industry, airline companies from other countries seem to be the "ducks" who have very good foresight about passenger loads as more Chinese travellers prefer overseas destinations as their first choice for holidays, especially the three week-long holidays, Spring Festival, May Day and National Day.As the May Day holiday approaches,

  19. Four Novel Cellulose Synthase (CESA Genes from Birch (Betula platyphylla Suk. Involved in Primary and Secondary Cell Wall Biosynthesis

    Directory of Open Access Journals (Sweden)

    Xuemei Liu

    2012-09-01

    Full Text Available Cellulose synthase (CESA, which is an essential catalyst for the generation of plant cell wall biomass, is mainly encoded by the CesA gene family that contains ten or more members. In this study; four full-length cDNAs encoding CESA were isolated from Betula platyphylla Suk., which is an important timber species, using RT-PCR combined with the RACE method and were named as BplCesA3, −4, −7 and −8. These deduced CESAs contained the same typical domains and regions as their Arabidopsis homologs. The cDNA lengths differed among these four genes, as did the locations of the various protein domains inferred from the deduced amino acid sequences, which shared amino acid sequence identities ranging from only 63.8% to 70.5%. Real-time RT-PCR showed that all four BplCesAs were expressed at different levels in diverse tissues. Results indicated that BplCESA8 might be involved in secondary cell wall biosynthesis and floral development. BplCESA3 appeared in a unique expression pattern and was possibly involved in primary cell wall biosynthesis and seed development; it might also be related to the homogalacturonan synthesis. BplCESA7 and BplCESA4 may be related to the formation of a cellulose synthase complex and participate mainly in secondary cell wall biosynthesis. The extremely low expression abundance of the four BplCESAs in mature pollen suggested very little involvement of them in mature pollen formation in Betula. The distinct expression pattern of the four BplCesAs suggested they might participate in developments of various tissues and that they are possibly controlled by distinct mechanisms in Betula.

  20. U Suk! Participatory Media and Youth Experiences with Political Discourse

    Science.gov (United States)

    Middaugh, Ellen; Bowyer, Benjamin; Kahne, Joseph

    2017-01-01

    In light of evidence that the Internet, participatory media, and online communities are increasingly central to civic and political life, this article investigates online political discourse as a context of youth civic development. Drawing on a national survey of 2,519 youth, ages 15 to 24, we find that exposure to conflict in online discourse is…

  1. Expression of bgt gene in transgenic birch (Betula platyphylla Suk ...

    African Journals Online (AJOL)

    Study on the characteristics of integration and expression is the basis of genetic stability of foreign genes in transgenic trees. To obtain insight into the relationship of transgene copy number and expression level, we screened 22 transgenic birch lines. Southern blot analysis of the transgenic birch plants indicated that the ...

  2. Expression of bgt gene in transgenic birch (Betula platyphylla Suk.)

    African Journals Online (AJOL)

    STORAGESEVER

    2009-08-04

    Aug 4, 2009 ... Study on the characteristics of integration and expression is the basis of genetic stability of foreign genes in transgenic trees. To obtain insight into the relationship of transgene copy number and expression level, we screened 22 transgenic birch lines. Southern blot analysis of the transgenic birch.

  3. Mandando bocas: Woo and Sex among Sampadjudu Young Men

    Directory of Open Access Journals (Sweden)

    Francisco Miguel

    2016-11-01

    Full Text Available In this paper I deal with a Cape Verdean phenomenon: the mandar bocas (“to send mouths”. Specifically, I analyse the action of “mandar bocas” made by men in the town of Mindelo. At a first glance, this phenomenon could be quickly classified as “homophobic” slurs. I argue, however, that this is not the only possible interpretation of the phenomenon as “mandar bocas” is often a phase of a homoerotic courtship between young men in Cabo Verde, though permeated by masculinist signs.

  4. A spirited response: Malaysia's AIDS activists woo Muslim clerics.

    Science.gov (United States)

    Oorjitham, S

    1999-11-05

    Islamic clerics, scholars, activists, and other authorities in Malaysia decided to lay in education for everyone as a solution to the AIDS epidemic in their country. In addition, they called on the community to be caring towards sufferers, which they believe is the way of Islam. This resolution was agreed upon during a meeting wherein religious officials recognized their role in AIDS prevention by equipping people with spiritual values and teaching everyone compassion. The resolution, however, has challenged the orthodoxy in some Islamic circles where AIDS is regarded as a "manifestation of God's punishment" which has consequently scared off many Muslim sufferers from approaching religious bodies. Religious advisers also admits that their call for full information about prevention, from urging abstinence and marital fidelity to promoting the use of condoms, still needs to be supported by individual state authorities. Among the AIDS council's future plans are to set up an information booth at a Kuala Lumpur mosque and to raise awareness in state religious departments through a booklet entitled AIDS Education Through Imams.

  5. Chandra Observations of Tycho's Supernova Remnant U. Hwang , R ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    runaway thermal instabilities in a white dwarf. It was observed for 50 ks with the superb 0.5 resolution mirror on the Chandra X-ray .... emission that comes from ejecta that have propagated to the forward shock. Such a spectrum, taken from a portion of the west rim of the remnant, is shown in the right panel of Fig. 2. The fitted ...

  6. [Life and Works of Heo Yeng-suk, the First Female Medical Practitioner in Modern Korea].

    Science.gov (United States)

    Shin, Dong Won

    2012-04-30

    Heo Yongsuk (1897-1975) was the second female medical doctor to study Western medicine in a foreign country, the second female journalist, and the one of the representative 'new modern woman' in Korea. She is unfamiliar, however, to Korean people. Few historians of medicine and few researchers of the history of literature recall her for her own achievements, instead remembering her as a wife who saved her husband, Yi Gwangsu (1892~1950), the great novelist, from his dreadful tuberculosis. Removing her from the shadow of Yi Gwangsu, this paper tries to uncover her life and her contribution to Korean society during the Japanese colonial period. As a pioneer, she went to Japan to study medicine in 1914 for the purpose of breaking down the long-established custom of female patients, who abhorred showing their bodies to male doctors. After acquiring her license, she opened in Korea for women and children, though this clinic had a brief span of only two years owing to her devotion to caring for her husband as his disease worsened. She became a reporter in place of her husband for about two years. However, with her efforts, she gave women a considerable amount of useful medical information. She wrote many enlightening articles to awaken Korean women's 'nationalistic spirit' against Japanese colonial oppression. She is worthy of a favorable evaluation as the second female reporter and the first who specialized in medicine in the history of newspapers in Korea. As a 'new modern woman,' she presented her own thinking about the best role model for married females, by saying, "Be good mother and good wife in the family household, it is the best way to strengthen Korean race." When she became pregnant, she resigned her job as a reporter. She exerted herself by bringing up her children and nursing her sick husband, gaining fame as the representative of the conservative women's movement. Medical knowledge was always behind her various activities. She can be evaluated successfully as a medical doctor; after studying newly developed medical theory and skills for about two years in Japan, she established first the specialized hospital for delivery in 1937 and had great success. As a successful female doctor, she projected a positive image of a new modern woman who was loyal to her family household, unlike many famous modern females who pursued women's liberation during the Japanese colonial period.

  7. Playing Roles (A Reading of Virginia Wooľf's Novel To the Lighthouse)

    OpenAIRE

    Petrić-Bajlo, Estella

    1997-01-01

    Reading Virginia Woolf's novel To the Lighthouse in the light of the generally known understanding of art as subjective reflection of objective reality, we might conclude that this novel interrogates not only the subjectivity of that reflection but the objectivity of reality as well. A prevailing sense of seemingness stems especially from Lily Briscoe°s doing a painting which metonymically corresponds to the narrating of the story (Grgas 1988). The closing sentence of the novel, »I have...

  8. Vendors woo South Africa as a potential new 'powerhouse' for nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear24, London (United Kingdom)

    2014-04-15

    South Africa is a country which is increasingly seen as a potential new nuclear market that promises to give one or more of the world's major nuclear vendors an important foothold on the continent. South Africa has two pressurised water reactors operating at the Koeberg nuclear plant. The 930-megawatt (MW) first unit entered commercial operation in July 1984, followed by the second (900 MW) unit in November 1985. These are the only commercial nuclear power plants on the continent of Africa. South Africa's updated draft integrated resources plan (IRP) for electricity for 2010-30, for which a public consultation period ended in February of this year, included revised projections. that suggested no new nuclear baseload capacity would be needed 'until after 2025'. A capacity 'at least 6,600 MW less' is required in terms of reliable overall generating capacity in 2030. However great South Africa's demand for a clean, affordable and reliable supply of nuclear-generated electricity, coupled with the economic benefits such developments will bring, investors also understand the potential for nuclear growth in this part of the world. (orig.)

  9. Listening to Hyun-woo: What Can We Learn from a Korean American English Learner?

    Science.gov (United States)

    Han, Keonghee Tao; Scull, W. Reed

    2012-01-01

    English learners (ELs) from Confucian heritage culture (CHC) are often perceived to be reserved and conforming to the authority of the classroom. But a careful look at struggles between a CHC student and the mainstream teacher reveals that the teacher's views and pedagogical approaches shape academic and social hierarchy in the classroom.…

  10. Vendors woo South Africa as a potential new 'powerhouse' for nuclear

    International Nuclear Information System (INIS)

    Shepherd, John

    2014-01-01

    South Africa is a country which is increasingly seen as a potential new nuclear market that promises to give one or more of the world's major nuclear vendors an important foothold on the continent. South Africa has two pressurised water reactors operating at the Koeberg nuclear plant. The 930-megawatt (MW) first unit entered commercial operation in July 1984, followed by the second (900 MW) unit in November 1985. These are the only commercial nuclear power plants on the continent of Africa. South Africa's updated draft integrated resources plan (IRP) for electricity for 2010-30, for which a public consultation period ended in February of this year, included revised projections. that suggested no new nuclear baseload capacity would be needed 'until after 2025'. A capacity 'at least 6,600 MW less' is required in terms of reliable overall generating capacity in 2030. However great South Africa's demand for a clean, affordable and reliable supply of nuclear-generated electricity, coupled with the economic benefits such developments will bring, investors also understand the potential for nuclear growth in this part of the world. (orig.)

  11. Insights for integrated conservation from attitudes of people toward protected areas near Hwange National Park, Zimbabwe.

    Science.gov (United States)

    Guerbois, Chloe; Dufour, Anne-Beatrice; Mtare, Godfrey; Fritz, Herve

    2013-08-01

    Increase in human settlements at the edge of protected areas (PAs) is perceived as a major threat to conservation of biodiversity. Although it is crucial to integrate the interests of surrounding communities into PA management, key drivers of changes in local populations and the effects of conservation on local livelihoods and perceptions remain poorly understood. We assessed population changes from 1990 to 2010 in 9 villages located between 2 PAs with different management policies (access to natural resources or not). We conducted semi-directive interviews at the household level (n =217) to document reasons for settlement in the area and villager's attitudes toward the PAs. We examined drivers of these attitudes relative to household typology, feelings about conservation, and concerns for the future with mixed linear models. Population increased by 61% from 2000 to 2010, a period of political and economic crisis in Zimbabwe. Forty-seven percent of immigrants were attracted by the area; others had been resettled from other villages or were returning to family lands. Attitudes toward PAs were generally positive, but immigrants attracted by the area and who used resources within the PA with fewer restrictions expressed more negative attitudes toward PAs. Household location, losses due to wild animals, and restrictions on access to natural resources were the main drivers of this negative attitude. Profit-seeking migrants did not expect these constraints and were particularly concerned with local overpopulation and access to natural resources. To avoid socio-ecological traps near PAs (i.e., unforeseen reduced adaptive capacity) integrated conservation should address mismatches between management policy and local expectations. This requires accounting for endogenous processes, for example, local socio-ecological dynamics and values that shape the coexistence between humans and wildlife. © 2013 Society for Conservation Biology.

  12. In the Shadows of a Diva: Committing Homosexuality in David Henry Hwang's "M. Butterfly."

    Science.gov (United States)

    Eng, David L.

    1994-01-01

    Discusses racism, sexism, and sexual orientation through an analysis of the play "M. Butterfly." Focusing on the French diplomat, Gallimard, the essay discusses sexual orientation, explores Gallimard's racist investments in his orientalized vision of Song, and discusses his attempt to explain his love affair as heterosexual love gone…

  13. Vidutinių sumų mokėjimo sistemos sukūrimas ir tyrimas

    OpenAIRE

    Zenkus, Irmantas

    2011-01-01

    Traditional models of electronic money, usually used for electronic payment systems are not adap- ted for small amounts of high-volume transactions. When the product is very low value, such as music, art, transport tickets, traditional schemes are far from ideal. Payments must be made very quickly, wi- thout requiring significant system resources. As we know the system resources cost money, and some low-value goods would become cheaper than the transaction costs. In this work i...

  14. Wooing the Dark Continent: U.S. and China Engagement Strategy in Africa, is it Complimentary or Competition

    Science.gov (United States)

    2008-05-01

    put it directly in conflict with Tokyo in the South China Sea . China has been successful in using its “soft power” to reduce the leverage of the West...59Ibid., 20. 60Gill and Reilly, 43. 30 The Two China’s as well as the Mutually Parasitic Economies (US/China...environment for all parties involved. African Perspectives “Panda Hug or Dragon Bite?” “Until the lion has his or her own storyteller, the hunter will

  15. Stem-cell spin: Covering the Hwang-affair in Science and Nature

    DEFF Research Database (Denmark)

    Kjærgaard, Rikke Schmidt

    2011-01-01

    and framed as a cynical director of a cloning factory. Media studies of science and technology tend to focus almost exclusively on how this framing process works in the mass media and ignore that this process is already well under way in scientific journals that then feed into mass media news stories. Thus...

  16. To Twitter to Woo: Harnessing the power of social media (SoMe) in nurse education to enhance the student's experience.

    Science.gov (United States)

    Sinclair, Wendy; McLoughlin, Moira; Warne, Tony

    2015-11-01

    This paper explores some of the difficulties, challenges and rewards for student nurses and nurse academics when harnessing social media (SoMe) as part of the overall learning experience. The paper draws upon data in the form of student voices, captured through an online planned Twitter chat. This data analysis provides the basis of a case study on the student experience in practice placements. A planned 1 h Twitter chat took place in June 2013, specifically aimed at student nurses. What transpired was an illuminating debate, eliciting responses from around the globe about learning in practice, mentors, and student support that lasted over 3 h. More importantly, the Twitter chat also included qualified nurses and mentors, listening and responding in real time, offering thoughts and solutions to how support and mentoring could be improved. This was in contrast to how students, locally, currently use a paper based questionnaire to give feedback in isolation. The authenticity of this feedback is often compromised by university link lecturers' who often provide a more sanitised version of this feedback to clinical placement. This paper explores whether it is possible to facilitate a realignment and capture the zeitgeist in order to provide the opportunity for enhancing learning in practice. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Is the Use of Video Conferencing and Supporting Technologies a Feasible and Viable Way to Woo Farmers Back into Farmer Education?

    Science.gov (United States)

    Brown, Margaret; Fraser, Tom

    2011-01-01

    North Dakota State University (USA) have been using video conferencing as a delivery mode for farmer education for about twenty years and report that their farmers find this delivery method both practical and worthwhile. With the number of New Zealand farmers attending learning events decreasing, due mainly to time and cost, maybe it is time to…

  18. The Effect of Hominis Placenta Herbal Acupuncture on Bell's palsy

    Directory of Open Access Journals (Sweden)

    Yun Jeong-hun

    2000-07-01

    Full Text Available This report was done to observe the effect of Hominis placenta herbal acupuncture on Bell's palsy. The study group comprised 16 patients who arrived at Woo-suk university oriental hospital from January, 1999 till January, 2000 for Bell's palsy. All patients were divided into two group. One was herbal acupunture group, and the other was control group. Acupunture group was done herbal acupuncture therapy on the facial acupuncture points. Followings are achievement and a term of each group. In herbal acupuncture group, 100% motor recovery was 7 case, 75% was 1 case, and 25% motor recovery term was 7.38±5.21 days, 50% was 11.00±6.16 days, 75% was 15.13±9.55 days, 100% was 23.14±7.97 days. In control group, 100% motor recovery was 4 case, 75% was 2 case, 25% below was 2 case and 25% motor recovery term was 11.17±4.96days, 50% was 18.17±6.82 days, 75% was 29.50±6.95 days, 100% was 44.00±11.49 days. The above results indicate that Hominis placenta herbal acupuncture is a useful effect on Bell's palsy. thus, continuous herbal acupunture study will be needed for more clinical application on Bell' palsy.

  19. Quantitative measurements of C-reactive protein using silicon nanowire arrays

    Directory of Open Access Journals (Sweden)

    Min-Ho Lee

    2008-03-01

    Full Text Available Min-Ho Lee, Kuk-Nyung Lee, Suk-Won Jung, Won-Hyo Kim, Kyu-Sik Shin, Woo-Kyeong SeongKorea Electronics Technology Institute, Gyeonggi, KoreaAbstract: A silicon nanowire-based sensor for biological application showed highly desirable electrical responses to either pH changes or receptor-ligand interactions such as protein disease markers, viruses, and DNA hybridization. Furthermore, because the silicon nanowire can display results in real-time, it may possess superior characteristics for biosensing than those demonstrated in previously studied methods. However, despite its promising potential and advantages, certain process-related limitations of the device, due to its size and material characteristics, need to be addressed. In this article, we suggest possible solutions. We fabricated silicon nanowire using a top-down and low cost micromachining method, and evaluate the sensing of molecules after transfer and surface modifications. Our newly designed method can be used to attach highly ordered nanowires to various substrates, to form a nanowire array device, which needs to follow a series of repetitive steps in conventional fabrication technology based on a vapor-liquid-solid (VLS method. For evaluation, we demonstrated that our newly fabricated silicon nanowire arrays could detect pH changes as well as streptavidin-biotin binding events. As well as the initial proof-of-principle studies, C-reactive protein binding was measured: electrical signals were changed in a linear fashion with the concentration (1 fM to 1 nM in PBS containing 1.37 mM of salts. Finally, to address the effects of Debye length, silicon nanowires coupled with antigen proteins underwent electrical signal changes as the salt concentration changed.Keywords: silicon nanowire array, C-reactive protein, vapor-liquid-solid method

  20. Recent advances in elasticity, viscoelasticity and inelasticity

    CERN Document Server

    Rajagopal, KR

    1995-01-01

    This is a collection of papers dedicated to Prof T C Woo to mark his 70th birthday. The papers focus on recent advances in elasticity, viscoelasticity and inelasticity, which are related to Prof Woo's work. Prof Woo's recent work concentrates on the viscoelastic and viscoplastic response of metals and plastics when thermal effects are significant, and the papers here address open questions in these and related areas.

  1. Geopressured-geothermal aquifers. Final contract report

    Energy Technology Data Exchange (ETDEWEB)

    1983-08-01

    Task 1 is to provide petrophysical and reservoir analysis of wells drilled into geopressured-geothermal aquifers containing dissolved methane. The list of Design Wells and Wells of Opportunity analyzed: Fairfax Foster Sutter No. 2 (WOO), Pleasant Bayou No. 2 (Design), Amoco Fee No. 1 (Design), G.M. Koelemay No. 1 (WOO), Gladys McCall No. 1 (Design), P.R. Girouard No. 1 (WOO), and Crown Zellerbach No. 2 (WOO). Petrophysical and reservoir analysis of the above wells were performed based on availability of data. The analysis performed on each well, the assumptions made during simulation, and conclusions reached.

  2. A semi-automatic system for labelling seafood products and ...

    African Journals Online (AJOL)

    STORAGESEVER

    2010-05-10

    May 10, 2010 ... oleanolic acid) may be produced in B. platyphylla Suk. cell culture, but their ..... Yeast extract and methyl jasmonate-induced silymarin production in ... alternata 102: Antagonistic effect of salicylic acid and methyl jasmonate on ...

  3. Design Copyright: The Latest Judicial Hint

    OpenAIRE

    Scott Hemphill; Jeannie Suk

    2013-01-01

    The most intriguing aspect of the debate over fashion copyright is the occasion it presents for rethinking the expansive copyright law we currently have. C. Scott Hemphill (Columbia Law) & Jeannie Suk (Harvard Law)

  4. Digital Review of Asia Pacific 2009–2010 | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2009-06-02

    Jun 2, 2009 ... Hyeun-Suk Rhee (Director, Asian and Pacific Training Centre for ... for the policymakers, government leaders, and public sector managers. ... Call for new OWSD Fellowships for Early Career Women Scientists now open.

  5. Duality relations between SU(N)k and SU(k)NWZW models and their braid matrices

    International Nuclear Information System (INIS)

    Naculich, S.G.; Schnitzer, H.J.

    1990-01-01

    Dual relations are found between the primary fields, correlators, and conformal blocks of SU(N) k and SU(k) N WZW models, which in turn imply dual relations between the braid matrices of the two theories. These results are a consequence of the fact that the spaces of conformal blocks of SU(N) k and SU(k) N correlation functions are dual. (orig.)

  6. A System for Controlled Presentation of the Arden Contrast Sensitivity Test.

    Science.gov (United States)

    1985-12-01

    and Woo,1978); I.?glaucoma (Atkin, et al,1979); amblyopia (Hess,1979); retinal degeneration (Woo and Long,1979); multiple sclerosis (Regan, et al...decrease, contrast sensitivity diminishes, and imaging L shifts to an area covering 12 -15 of the peripheral macula . The theoretical threshold grid

  7. The rectilinear Steiner ratio

    Directory of Open Access Journals (Sweden)

    PO de Wet

    2005-06-01

    Full Text Available The rectilinear Steiner ratio was shown to be 3/2 by Hwang [Hwang FK, 1976, On Steiner minimal trees with rectilinear distance, SIAM Journal on Applied Mathematics, 30, pp. 104– 114.]. We use continuity and introduce restricted point sets to obtain an alternative, short and self-contained proof of this result.

  8. The rectilinear Steiner ratio | de Wet | ORiON

    African Journals Online (AJOL)

    The rectilinear Steiner ratio was shown to be 3/2 by Hwang [Hwang FK, 1976, On Steiner minimal trees with rectilinear distance, SIAM Journal on Applied Mathematics, 30, pp. 104–114.]. We use continuity and introduce restricted point sets to obtain an alternative, short and self-contained proof of this result. Key words: ...

  9. Luteoloside Inhibits Proliferation of Human Chronic Myeloid ...

    African Journals Online (AJOL)

    Purpose: To investigate the effects of luteoloside on the proliferation of human chronic ..... Zhang N, Wang D, Zhu Y, Wang J, Lin H. Inhibition ... Han X. Protection of Luteolin-7-O-Glucoside Against ... Hwang YJ, Lee EJ, Kim HR, Hwang KA.

  10. Committees

    Science.gov (United States)

    2012-11-01

    Leadership Team of the IAHR Committee for Hydraulic Machinery and Systems Eduard EGUSQUIZA, UPC Barcelona, Spain, Chair François AVELLAN, EPFL-LMH, Switzerland, Past Chair Richard K FISHER, Voith Hydro Inc., USA, Past Chair Fidel ARZOLA, Edelca, Venezuela Michel COUSTON, Alstom Hydro, France Niklas DAHLBÄCKCK, Vatenfall, Sweden Normand DESY, Andritz VA TECH Hydro Ltd., Canada Chisachi KATO, University of Tokyo, Japan Andrei LIPEJ, Turboinstitut, Slovenija Torbjørn NIELSEN, NTNU, Norway Romeo SUSAN-RESIGA, 'Politehnica' University Timisoara, Romania Stefan RIEDELBAUCH, Stuggart University, Germany Albert RUPRECHT, Stuttgart University, Germany Qing-Hua SHI, Dong Fang Electrical Machinery Co., China Geraldo TIAGO, Universidade Federal de Itajubá, Brazil International Advisory Committee Shouqi YUAN (principal) Jiangsu University China QingHua SHI (principal) Dong Fang Electrical Machinery Co. China Fidel ARZOLA EDELCA Venezuela Thomas ASCHENBRENNER Voith Hydro GmbH & Co. KG Germany Anton BERGANT Litostroj Power doo Slovenia B C BHAOYAL Research & Technology Centre India Hermod BREKKE NTNU Norway Stuart COULSON Voith Hydro Inc. USA Paul COOPER Fluid Machinery Research Inc USA V A DEMIANOV Power Machines OJSC Russia Bart van ESCH Technische Universiteit Eindhoven Netherland Arno GEHRER Andritz Hydro Graz Austria Akira GOTO Ebara Corporation Japan Adiel GUINZBURG The Boeing Company USA D-H HELLMANN KSB AG Germany Ashvin HOSANGADI Combustion Research and Flow Technology USA Byung-Sun HWANG Korea Institute of Material Science Korea Toshiaki KANEMOTO Kyushu Institute of Technology Japan Mann-Eung KIM Korean Register of Shipping Korea Jiri KOUTNIK Voith Hydro GmbH & Co. KG Germany Jinkook LEE Eaton Corporation USA Young-Ho LEE Korea Maritime University Korea Woo-Seop LIM Hyosung Goodsprings Inc Korea Jun MATSUI Yokohama National University Japan Kazuyoshi Mitsubishi H I Ltd, Japan MIYAGAWA Christophe NICOLET Power Vision Engineering Srl Switzerland Maryse PAGE Hydro

  11. Piezoelectric Nanogenerators for Self-Powered Nanosystems and Nanosensors

    Science.gov (United States)

    2013-05-15

    researchers 1. Sangmin Lee, Sung-Hwan Bae, Long Lin, Seunghyun Ahn, Chan Park, Seung Nam Cha, Young Jun Park, Hyuk Chang, Sang-Woo Kim and...Sohn, Seung Nam Cha, Dukhyun Choi * Zhong Lin Wang * Sang-Woo Kim * “ P-Type Polymer–Hybridized High-Performance Piezoelectric Nanogenerators”, Nano...Yoon Lee, † Sang-Woo Kim , *,$ Jae-Young Choi, *,† Jong Min Kim , † and Zhong Lin Wang *, “Flexible Hybrid Multi-Type Energy Scavenger”, Energy

  12. Some relevant properties of SO(n) representations for Grand unified theories

    International Nuclear Information System (INIS)

    Girardi, G.; Sorba, P.; Sciarrino, A.

    1980-05-01

    General properties of the SO(n) groups are examined, with emphasis on the usefulness of the Gel'fand-Zetlin basis for explicit calculations. The SO(n) representations containing a vector stabilized by subgroups of the type S[O(n-p) x O(p)], SU(k) x U(1) or SU(k) if n=2k, are characterized in view of selecting Higgs representations in SO(n) gauge models. Some useful properties of the SU(n) Gel'fand-Zetlin basis are given in the appendices

  13. Download this PDF file

    African Journals Online (AJOL)

    ... is an acquired skill of expressing a particular culture so that the message conveyed to the .... are beyond the control of a small-scale processor. Perhaps some .... Champman and Hall. Hardter, R., Woo ... Experience. London: Edward Arnold.

  14. Stalkerid sisekujundusmaastikul / Jan Joonas Graps, Ken-Kristjan Ruut ; intervjueerinud Aale Kask

    Index Scriptorium Estoniae

    Graps, Jan Joonas, 1972-

    2008-01-01

    Sisearhitektide Jan Joonas Grapsi ja Ken-Kristjan Ruudu loomingust, tehtud tööde loetelu. Sarjast WooDoo. Pelgulinnas Kaera 22 asuva korteri (arhitekt Harry Klaar) ja Murastes asuva eramu (arhitekt Mart Kadarik) sisekujundusest

  15. The Global Reach of Chinese Soft Power: China's Rise and America's Decline?

    National Research Council Canada - National Science Library

    Hoey, James H

    2007-01-01

    ...." Emerging from a shell of defensive diplomacy dating back decades, China suddenly has engaged the world, wooing friends with a subtle, softer approach to make gains as America's popularity has plummeted...

  16. Kes kardab Park Chan-Wooki? / Karlo Funk

    Index Scriptorium Estoniae

    Funk, Karlo, 1971-

    2007-01-01

    Vägivalla ajendite teemadel. USA meedia süüdistas peale Virginia koolitulistamist filmikunsti. Seoseid ja/või põhjusi otsiti korealase Park Chan-Wooki filmist "Vana poiss" ("Old Boy") ja John Woo filmidest

  17. Growth of mycotal species on the eggs of Cyprinus carpio in ...

    African Journals Online (AJOL)

    aghomotsegin

    2015-02-11

    Feb 11, 2015 ... Key words: Cyprinus carpio, common carp, eggs, mycotal species, infections, ..... Woo PTK, Bruno DW (Eds.) Fish Diseases and Disorders. Viral, ... like organism developing on the eggs of pink salmon Oncorhynchus.

  18. Eto vam ne Dzheims Bond / Vincent Vega

    Index Scriptorium Estoniae

    Vega, Vincent

    2000-01-01

    Actionfilmi "Võimatu missioon" ("Mission : Impossible") järg "Võimatu Missioon 2 ("Mission : Impossible II") : režissöör John Woo : peaosaline ja produtsent Tom Cruise : Ameerika Ühendriigid 2000

  19. African Journal of Biotechnology - Vol 12, No 20 (2013)

    African Journals Online (AJOL)

    Rubisco activity and gene expression of tropical tree species under light stress · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Keum-Ah Lee, Seong Han Lee, Su Young Woo ...

  20. Review Cyclic AMP response element binding protein and brain ...

    Indian Academy of Sciences (India)

    Madhu

    Several types of adult-onset stressors, including physical and psychosocial stressors ... stress-induced atrophy with antidepressant therapy in animal models (Watanabe et ..... (Strauss et al 2005) and geriatric depression (Hwang et al. 2005).

  1. SELES

    DEFF Research Database (Denmark)

    Garcia-Zamora, Claudia; Rodriguez-Henriquez, Francisco; Ortiz-Arroyo, Daniel

    2005-01-01

    In this paper we present an improved e-voting protocol for online elections based on the scheme proposed by Lin--Hwang--Chang. We show that Lin--Hwang--Chang's scheme has two important weaknesses. We describe in detail our findings and propose a new scheme to overcome these weaknesses effectively....... To test our protocol, we implemented a distributed e-voting system. Finally we evaluate and compare our protocol with other previously proposed schemes....

  2. Assessment of Phospohrene Field Effect Transistors

    Science.gov (United States)

    2018-01-28

    majoring in electrical engineering were trained through the project. During the project period, one graduated with an MS degree, while another one...34Phosphorene FETs-Promising Transistors Based on a few Layers of Phosphorus Atoms," Chinese Academy of Engineering , Chengdu, China, Jul. 2015. J.C. M. Hwang... Nanotechnology , Arlington, VA, Oct.2015. J. C. M. Hwang, "Surface Passivation and RF Characterization of Phosphorene FETs," Air Force Research Lab, Dayton

  3. The stability of transgene expression and effect of DNA methylation ...

    African Journals Online (AJOL)

    In this paper, we selected transgenic birch (Betula platyphylla Suk) plants, which included nonsilencing plants, transcriptional silence plants including TP96, TP74, TP73 and the post-transcriptional silence ones (TP67 and TP72). The transcription of the bgt gene in different tissues and organs were significantly different.

  4. Aitab pillamisest, Ameerika / Kenneth Rogoff

    Index Scriptorium Estoniae

    Rogoff, Kenneth

    2006-01-01

    Hoolimata sellest, et USA paiskab atmosfääri umbes 25% kogu inimtegevuse tagajärjel tekkinud süsinikust, ei kavatse ameeriklased oma tarbimist vähendada. Majandusteadlased peavad väljapääsuks ühtlast globaalset süsinikuheidetele kehtestatud maksu

  5. Korean Affairs Report, No. 315.

    Science.gov (United States)

    1983-10-24

    SHOW—The Korea-Soviet friendship society held a film showing on 11 May at the Nagwon Cinema on the occasion of the 38th anniversary of Soviet victory... PERUVIAN COMMUNIST ARRIVES—The following greeted the 23 May arrival of the General Secretary of the Peruvian Communist Party: Ho Chong-suk secretary

  6. Estimating carbon emissions from forest fires during 1980 to 1999 in ...

    African Journals Online (AJOL)

    white birch (Betula platyphylla Suk.), mixed broadleaved-conifer (L. gmelinii & B. platyphylla) and Mongolian oak (Quercus mongolica Fish.) forests were 437 947, 20 939, 142 527, 168 532 and 1 375 hm2 during 1980 to 1999 period, respectively. The fuel consumed based on these forests were 29.0 to 46.5, 16.7 to 26.5, ...

  7. The effects of growth time on the quality of graphene synthesized by ...

    Indian Academy of Sciences (India)

    by LPCVD. A JAFARI, R ALIPOUR∗ and M GHORANNEVISS ..... Li T, Hass J, Marchenkoy A N, Conrad E H, First P N and de ... Ni Z H, Chen W, Fan X F, Kuo J L, Yu T, Wee A T S ... Chen S, Cai W, Piner R D, Suk J W, Wu Y, Ren Y, Kang Y.

  8. Med Kingo på dybt vand

    DEFF Research Database (Denmark)

    Arndal, Lars Stubbe

    2014-01-01

    Tag med digteren Thomas Kingo ud på dybt vand i selskab med lektor og mag.art. Lars Arndal, der kaster nye perspektiver på Kingos forlisdigt Hierte-Suk. Arndal kommer hermed også med et bud på, hvordan man som lærer kan invitere eleverne med på opdagelse i digtet...

  9. South Asia | Page 113 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    As such, it is a tremendously valuable resource for the policymakers, government leaders, and public sector managers. — Hyeun-Suk Rhee (Director, Asian and Pacific Training Centre for Information and Communication Technology for Development, Incheon, Republic of Korea). Read more about Digital Review of Asia ...

  10. South Asia | Page 112 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    As such, it is a tremendously valuable resource for the policymakers, government leaders, and public sector managers. — Hyeun-Suk Rhee (Director, Asian and Pacific Training Centre for Information and Communication Technology for Development, Incheon, Republic of Korea). Read more about Digital Review of Asia ...

  11. Far East Asia | Page 187 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Hyeun-Suk Rhee (Director, Asian and Pacific Training Centre for Information and Communication Technology for Development, Incheon, Republic of Korea). Read more about Digital Review of Asia Pacific 2009–2010. Language English. Les exemples présentés dans Success Stories in Asian Aquaculture illustrent la ...

  12. Kunst rahvani ehk Kwangju biennaal / Siram

    Index Scriptorium Estoniae

    Siram, pseud., 1968-

    2004-01-01

    Biennaal "Tolmutera, veetilk" Lõuna-Koreas, avatud kuni 13. XI 2004. Kuraatorid Yongwoo Lee (New York, Soul), Kerry Brougher (Washington-distrikt), Suk-won Chang (Kwangju). City Light Award - Watercio Caldas (Brasiilia), Korea fondi preemia - Jennifer Allora ja Guillermo Calzadilla (Kuuba) jt. Johann Köleri nim. Positivistlik Kunsttööstuskool osales biennaali performance'iprogrammis

  13. Mõtisklus kivirannal : Visby rahvusvaheline heliloojate keskus kui loominguline pelgupaik / Mirjam Tally

    Index Scriptorium Estoniae

    Tally, Mirjam, 1976-

    2008-01-01

    Gotlandi saarel asuvast heliloojate keskusest. Lühiintervjuu hiljuti keskuses töötanud kahe heliloojaga - Lõuna-Koreast pärit, ent Floridas elava Suk-Jun Kim'i ja Lõuna-Aafrikast vabariigist pärit Clare Loveday'ga

  14. EDITORIAL: Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010) Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010)

    Science.gov (United States)

    Takahashi, M.; Saito, H.

    2011-02-01

    overseas. The programme involved 4 plenary talks, 37 invited talks, 85 contributed talks and 352 posters. All submitted papers were reviewed in order to meet the standards of Journal of Physics D: Applied Physics and Journal of Physics: Conference Series. We are grateful to all participants for their valuable contributions and active discussions. We gratefully acknowledge the financial support of 17 Japanese companies and 7 Japanese foundations. Invited papers from ISAMMA 2010 Contents Current status and recent topics of rare-earth permanent magnets S Sugimoto Alloying effect on the magnetic properties of RFeB-type bulk magnets H W Chang, C C Hsieh, J Y Gan, Y T Cheng, M F Shih and W C Chang Coercivity distributions in Nd-Fe-B sintered magnets produced by the grain boundary diffusion process H Nakamura, K Hirota, T Ohashi and T Minowa Recent progress in high Bs Fe-based nanocrystalline soft magnetic alloys M Ohta and Y Yoshizawa Electric-field effects on magnetic anisotropy in Pd/Fe/Pd(0 0 1) surface Shinya Haraguchi, Masahito Tsujikawa, Junpei Gotou and Tatsuki Oda Gate modulation of spin precession in a semiconductor channel Hyun Cheol Koo, Jae Hyun Kwon, Jonghwa Eom, Joonyeon Chang, Suk Hee Han and Mark Johnson Ferromagnetic resonance of epitaxial Fe nanodots grown on MgO measured using coplanar waveguides M Mizuguchi and K Takanashi Switching phase diagrams of current-induced magnetization switching in asymmetric MgO-based magnetic tunnel junctions Seung-Young Park, Jae-Ho Han, Se-Chung Oh, Jang-Eun Lee, Kyung-Tae Nam, Hyun-Woo Lee, Younghun Jo and Kyung-Jin Lee Temperature dependence of spin-dependent transport properties of Co2MnSi-based current-perpendicular-to-plane magnetoresistive devices Y Sakuraba, K Izumi, S Bosu, K Saito and K Takanashi Adsorbate-induced spin-polarization enhancement of Fe3O4(0 0 1) A Pratt, M Kurahashi, X Sun and Y Yamauchi Antiferromagnetic coupling between spinel ferrite and α-Fe layers in Fe3-δO4/MgO/Fe(0 0 1) epitaxial films Hideto

  15. Prime Contract Awards by State or Country, Place and Contractor. Part 13 (New London, Ohio - Westerly, Rhode Island), FY1991

    Science.gov (United States)

    1991-01-01

    C .4uO > NMX jInI n-4 r- -4 >0a0 0a 0 X 11 M -4 it 000C000 00 000C>-4 0. on n0000 - -1 4D to "c0200 00O c > : Q 10 1(0 -4 I1 r- -q a)on Coo -4 r𔃼m00...o004 inn = In0 N -a 1 a (-4 gao LCao Wo LA4 0*v 0 Z2o0o000 ix N N. " 0 I (a0-4 N t I0) C.0C -JOC) Woo 4 -444 q0 0 1- Nr EU a (04 N aJO WOO 0.4 woo

  16. Resurfacing hemiarthroplasty compared to stemmed hemiarthroplasty for glenohumeral osteoarthritis

    DEFF Research Database (Denmark)

    Rasmussen, Jeppe V; Olsen, Bo S; Sorensen, Anne Kathrine

    2015-01-01

    PURPOSE: The aim of this study was to conduct a randomised, clinical trial comparing stemmed hemiarthroplasty and resurfacing hemiarthroplasty in the treatment of glenohumeral osteoarthritis. METHODS: A total of 40 shoulders (35 patients) were randomised to stemmed hemiarthroplasty or resurfacing...... hemiarthroplasty and evaluated three and 12 months postoperatively using the Constant-Murley score (CMS) and Western Ontario Osteoarthritis of the Shoulder (WOOS) index. RESULTS: There were no statistically significant differences in age, gender or pre-operative scores except for WOOS at baseline. Two patients...

  17. POSTERS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Natural Toxins   S01 Susceptibility of Edible Bihalves to Paralytic Shellfish Poisons and Their Donor   Ya-Hui Li* , Deng-Fwu Hwang, Jou-Fang Deng, Taibei, China      S02 Food Safety of Grass Carp Bile Juice   Deng-Fwu Hwang* , Yen-Hung Yeh, Jou-Feng Deng, Taibei, China      S03 Differentiation of Muscular Proteins from Toxic and Non Toxic Puffers   Tai-Yuan Chen* , Deng-Fwu Hwang, Taibei, China      S04 Radiation Resistance of Paralytic Shellfish Poison (PSP) Toxins   Terestia P Acevedo, Philippines

  18. On the Security of a Simple Three-Party Key Exchange Protocol without Server’s Public Keys

    Directory of Open Access Journals (Sweden)

    Junghyun Nam

    2014-01-01

    Full Text Available Authenticated key exchange protocols are of fundamental importance in securing communications and are now extensively deployed for use in various real-world network applications. In this work, we reveal major previously unpublished security vulnerabilities in the password-based authenticated three-party key exchange protocol according to Lee and Hwang (2010: (1 the Lee-Hwang protocol is susceptible to a man-in-the-middle attack and thus fails to achieve implicit key authentication; (2 the protocol cannot protect clients’ passwords against an offline dictionary attack; and (3 the indistinguishability-based security of the protocol can be easily broken even in the presence of a passive adversary. We also propose an improved password-based authenticated three-party key exchange protocol that addresses the security vulnerabilities identified in the Lee-Hwang protocol.

  19. Discovery of FDA-Approved Drugs that Promote Retinal Cell Survival or Regeneration

    Science.gov (United States)

    2015-10-01

    disturbing agent against microorganisms Y Secondary ARQiv screens are ongoing whereby the three most effective concentrations will be re-tested at a...91,976 Preparation/Characterization of Bioabsorbable, antibiotic-eluting sutures Our goal is to develop biodegradable , polymeric sutures of the...vehicle. R01HL127413 (Hanes/Suk) 04/01/15 – 02/28/19 0.6 calendar NIH/NHLBI $263,000 Biodegradable Mucus Penetrating DNA Nanoparticle for

  20. Efficacy and safety of fixed-combination bimatoprost/timolol ophthalmic solution

    OpenAIRE

    Moon, Suk Bae; Han, Sang Beom

    2017-01-01

    Suk Bae Moon,1 Sang Beom Han21Department of Surgery, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, Korea, 2Department of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, KoreaWe read, with interest, the article by Sun et al1 entitled “Patient satisfaction with fixed-combination bimatoprost/timolol ophthalmic solution: a survey study in patients with gla...

  1. Trans World Tidal Gravity Profile.

    Science.gov (United States)

    1984-12-31

    SUL COMPOSANTE VEPTICALE ERESIL 29 40 17S 53 49 22W H 700M P 2M 0 330KM DEPOTS SEDIMENTAIRES SUk BASALTE DEPT* DE INGENIERIA RURAL-UNIV. FED. DE SANTA...AMERICA STATION VICOSA STATION 7308 VICOSA MINAS GERAIS COMPOSANTE VERTICALE BRESIL 20 45 20S 42 52 04W H .650M P OH C 400100, DEPT. DE ENC. CIVIL

  2. Rotation invariants from Gaussian-Hermite moments of color images

    Czech Academy of Sciences Publication Activity Database

    Yang, B.; Suk, Tomáš; Flusser, Jan; Shi, Z.; Chen, X.

    2018-01-01

    Roč. 143, č. 1 (2018), s. 282-291 ISSN 0165-1684 R&D Projects: GA ČR GA15-16928S Institutional support: RVO:67985556 Keywords : Color images * Object recognition * Rotation invariants * Gaussian–Hermite moments * Joint invariants Subject RIV: JD - Computer Applications, Robotics Impact factor: 3.110, year: 2016 http://library.utia.cas.cz/separaty/2017/ZOI/suk-0479748.pdf

  3. Development of a Novel Synthetic Drug for Osteoporosis and Fracture Healing

    Science.gov (United States)

    2015-11-01

    Salubrinal is reported to reduce orofacial inflammatory pain [32], and it alleviates colitis through suppression of proinflammatory cytokines [33...828-835. 32. Yang ES, Bae JY, Kim TH, Kim YS, Suk K, Bae YC: Involvement of endoplasmic reticulum stress response in orofacial inflammatory pain ...LPS)-stimulated inflammatory responses in macrophages (14), reduce orofacial inflammatory pain (30), and alleviates colitis through suppression of pro

  4. Leaf Recognition of Woody Species in Central Europe

    Czech Academy of Sciences Publication Activity Database

    Novotný, P.; Suk, Tomáš

    2013-01-01

    Roč. 115, č. 4 (2013), s. 444-452 ISSN 1537-5110 R&D Projects: GA ČR GAP103/11/1552 Grant - others:GA UK(CZ) 524512/2012 Keywords : leaf recognition * image moment * Fourier descriptor * automated plant determination Subject RIV: IN - Informatics, Computer Science Impact factor: 1.367, year: 2013 http://library.utia.cas.cz/separaty/2013/ZOI/suk-0394324.pdf

  5. Recognition of Symmetric 3D Bodies

    Czech Academy of Sciences Publication Activity Database

    Suk, Tomáš; Flusser, Jan

    2014-01-01

    Roč. 6, č. 3 (2014), s. 722-757 ISSN 2073-8994 R&D Projects: GA ČR GAP103/11/1552 Institutional support: RVO:67985556 Keywords : rotation symmetry * reflection symmetry * 3D complex moments * 3D rotation invariants Subject RIV: JD - Computer Applications, Robotics Impact factor: 0.826, year: 2014 http://library.utia.cas.cz/separaty/2014/ZOI/suk-0431156.pdf

  6. Calculations of Energy Shift of the Conduction Band-Edge in Doped and Compensated GaP

    OpenAIRE

    Endo, Tamio; Itoh, Nobuhiko; Okino, Yasushi; 遠藤, 民生; 伊藤, 伸彦; 沖野, 祥[他

    1989-01-01

    The energy shifts of the parabolic conduction band-edge at 77 and 300K with doping the Te-donor in GaP were calculated in the nondegenerate system for the two cases ; unintentional and intentional compensations, using the two models proposed by Hwang abd by Mahan. The total parabolic shift △EM(△EH), and the contributions of the exchangeinteraction △μex(△Ee) and of the Coulomb interaction △μed(△Ec) calculated by the Mahan's model (Hwang's model), increase with increasing donor concentration in...

  7. Seasonal Variation in Trypanosomosis Rates in Small Ruminants at ...

    African Journals Online (AJOL)

    Rev Dr Olaleye

    blood. The blood samples were kept cool by placing them in cold boxes containing ice packs after collection. Parasitological examination was done in the Laboratory using the haematocrit centrifugation technique, HCT (Woo, 1971), buffy coat method (BCM) (Murry et. al; 1977) and. Giemsa stained thin films made after BCM.

  8. A Framework for Interaction and Cognitive Engagement in Connectivist Learning Contexts

    Science.gov (United States)

    Wang, Zhijun; Chen, Li; Anderson, Terry

    2014-01-01

    Interaction has always been highly valued in education, especially in distance education (Moore, 1989; Anderson, 2003; Chen, 2004a; Woo & Reeves, 2007; Wang, 2013; Conrad, in press). It has been associated with motivation (Mahle, 2011; Wen-chi, et al., 2011), persistence (Tello, 2007; Joo, Lim, & Kim, 2011), deep learning (Offir, et al.,…

  9. NeighbourWoods for Better Cities

    DEFF Research Database (Denmark)

    Konijnendijk, Cecil Cornelis; Schipperijn, Jasper Jan

    This publication aims to contribute to the development af NeighbourWoods through socially-inclusive planning, design and management. It presents experiences from an international project supported by the European Commission which evaluated and developed approaches and tools to assist NeighbourWoo...

  10. An Exploration of Multiple Channel Evaluations in Attributions of Deception.

    Science.gov (United States)

    1980-11-24

    woo Id lit with11011 t lit’ d It ted i In Add flt lotia dcl In t foli! tidclt (le on loi it Ithioulgh socialit ivdl lv dit treit appear to dgrct, wi lIi...Specifically, a survey was designed for this purpose (Appendix B). The survey consisted of 12 statements, mostly political in nature, and allowed each

  11. Muusikauudiseid maailmast / Ia Remmel

    Index Scriptorium Estoniae

    Remmel, Ia, 1965-

    2016-01-01

    Lühisõnumeid maailmast: Suri Einojuhani Rautavaara. ECHO Klassiku 2017. aasta preemia saajad selgunud. Bachi haruldane käsikiri oksjonil. "Operalia 2016" võitjad on Keon-Woo Kim ja Elsa Dreisig. Shakespeare'i Globe asutas oma plaadimärgi. Sydney konkursi vitis vene pianist Andrei Gugnin. Noorel rootsi viiuldajal leping Deutsche Grammophoniga

  12. Anisotropic optical properties of ZnS thin films with zigzag structure

    Indian Academy of Sciences (India)

    2017-08-18

    Aug 18, 2017 ... shapes can be produced. In the earliest efforts .... Figure 2. (a) XRD patterns of ZnS films under different conditions .... are presented in figure 6a–c. In figure 6 ..... [13] Woo S-H and Hwangbo C K 2006 J. Korean Phys. Soc. 48.

  13. Studies of Giardia lamblia

    Science.gov (United States)

    1994-10-05

    isoenzyme analysis of 19 axenic strains isolated from symptomatic and asymptomatic patients in Mexico . Trans. R. Soc. Trop. Med. Hyg. 83 : 644-646...antibody studies with agents of Varicella and Herpes Zoster propagated in vitro. Proe. Soc. Exptl. BioI. Med . 86 :7 89-794. Woo, P. and G.S. Panayi

  14. Artificial intelligence expert systems with neural network machine learning may assist decision-making for extractions in orthodontic treatment planning.

    Science.gov (United States)

    Takada, Kenji

    2016-09-01

    New approach for the diagnosis of extractions with neural network machine learning. Seok-Ki Jung and Tae-Woo Kim. Am J Orthod Dentofacial Orthop 2016;149:127-33. Not reported. Mathematical modeling. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Sounds Exaggerate Visual Shape

    Science.gov (United States)

    Sweeny, Timothy D.; Guzman-Martinez, Emmanuel; Ortega, Laura; Grabowecky, Marcia; Suzuki, Satoru

    2012-01-01

    While perceiving speech, people see mouth shapes that are systematically associated with sounds. In particular, a vertically stretched mouth produces a /woo/ sound, whereas a horizontally stretched mouth produces a /wee/ sound. We demonstrate that hearing these speech sounds alters how we see aspect ratio, a basic visual feature that contributes…

  16. Higher Education and Entrepreneurial Citizenship in Singapore

    Science.gov (United States)

    Christensen, Soren

    2012-01-01

    Focusing on Singapore's "Global Schoolhouse" project, this article discusses how efforts to transform Singapore into a "world class" knowledge economy entail changes to the status of citizenship in Singapore. The project of wooing top foreign universities to Singapore is permeated with an entrepreneurial ideal of Singapore as…

  17. Academic Degradation and the Retreat of the Editors: Academic Irregularities and the Spreading of Academic Corruption from an Editor's Perspective

    Science.gov (United States)

    Xun, Gong

    2007-01-01

    Against the backdrop of the grave academic crisis in China, editors have become the objects of wooing, favor-currying, connections-seeking, and collusions; they have been targeted for attacks, plots, extortions, and encroachments. Editing and publishing have become avenues for academic irregularities and academic corruption. Editors have the power…

  18. Plants' responses to drought and shade environments

    African Journals Online (AJOL)

    전병기

    Among them, drought is widely known as the main factor that limits plants' growth, productivity and development (Reddy et al., 2004; Shao et al., 2008; Li et al., 2009). Recently, drought occured frequently all over the globe due to climate changes (Khaine and Woo, 2015). Light and shade are very important environements ...

  19. Neural Development in tsc2-Deficient Zebrafish

    Science.gov (United States)

    2011-10-01

    the cells in this region normally give rise to forebrain and retina (Woo and Fraser, 1995). Analyses of chimeric embryos at 7.5 dpf revealed that...white matter. Green color is tissue autofluorescence ; blue is DAPI staining. P, pallium; Po, preoptic region; Sd, dorsal division of subpallium; Tve

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Soo-Dong Woo1 Jae Young Choi2 Yeon Ho Je2 Byung Rae Jin3. Department of Plant Medicine, College of Agriculture, Life and Environment Sciences, Chungbuk National University, Cheongju 361-763, Korea; School of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul ...

  1. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 32; Issue 4. Molecular cloning and expression of the C-terminus of spider flagelliform silk protein from Araneus ventricosus. Kwang Sik Lee Bo Yeon Kim Yeon Ho Je Soo Dong Woo Hung Dae Sohn Byung Rae Jin. Articles Volume 32 Issue 4 June 2007 pp 705-712 ...

  2. Molecular mechanism of methionine differentiation in high and low ...

    African Journals Online (AJOL)

    User

    2011-05-09

    May 9, 2011 ... Key words: Maize, methionine, zein, storage protein, amino acid, real time PCR. INTRODUCTION ... programs should be started with main objectives to increase and ... (Woo et al., 2001), while beta zein have interaction with delta zein ... sion analysis of 27 kDa gamma zein and 16 kDa gamma zein, 22 kDa ...

  3. Brassia campestris L. ssp. chinensis L.var. utilis Tsen et Lee

    African Journals Online (AJOL)

    omodibo

    2012-12-31

    Dec 31, 2012 ... On the basis of morphological and cultural features, the pathogen ... Alternaria isolate from Purple-Caitai showed 99% identity with other ITS sequences of .... Cho KH, Park SH, Kim KT, Kim S, Kim JS, Park BS, Woo JG, Lee HJ.

  4. Expression of porcine myosin heavy chain 1 gene in Berkshire loins ...

    African Journals Online (AJOL)

    Expression of porcine myosin heavy chain 1 gene in Berkshire loins with a high pH24 value. Jin Hun Kang, Woo Young Bang, Eun Jung Kwon, Yong Hwa Lee, Da Hye Park, Eun Seok Cho, Min Ji Kim, Jong-Soon Choi, Hwa Chun Park, Beom Young Park, Chul Wook Kim ...

  5. Identification and chromosomal localization of repeat sequences ...

    Indian Academy of Sciences (India)

    Unknown

    woo BAC library containing a total of 150,000 clones with an average size of ... generate linkage maps of human and cattle as well as for other mammalian ..... gram, Rural Development Administration, Republic of Korea. We thank all our ...

  6. Public understanding: can we make an atom of difference?

    International Nuclear Information System (INIS)

    Harding, C.

    1990-01-01

    The Chairman of British Nuclear Fuels Limited proposes a fresh marketing approach for the image of nuclear power generation in the United Kingdom, in an attempt to woo public opinion. Openness and honesty are essential, and environmental issues, while important, should not be cynically exploited. The Visitors' Centre at Sellafield is cited as a good example of how this might be achieved. (UK)

  7. Outcome of Revision Shoulder Arthroplasty After Resurfacing Hemiarthroplasty in Patients with Glenohumeral Osteoarthritis

    DEFF Research Database (Denmark)

    Rasmussen, Jeppe V; Olsen, Bo S; Al-Hamdani, Ali

    2016-01-01

    hemiarthroplasty was 62 points (interquartile range, 40 to 88 points). Of the 80 cases that had follow-up, 33 (41%) had an unacceptable outcome, defined as a WOOS of ≤50 points. Of the 107 cases that required a revision surgical procedure, 11 arthroplasties (10%) required a further revision surgical procedure...

  8. Research

    African Journals Online (AJOL)

    ebutamanya

    2016-04-06

    Apr 6, 2016 ... areas of North America have a low prevalence (<2%). .... statistically significant relationship (p=0.046) between occupation of .... Polish perspectives. Annals of Agricultural and Environmental. Medicine. 2012;19(3):523-527. PubMed | Google Scholar. 5. Tong M, Hwang S. Hepatitis B virus infection in Asian.

  9. Oxygen transfer rates and requirements in oxidative biocatalysis

    DEFF Research Database (Denmark)

    Pedersen, Asbjørn Toftgaard; Rehn, Gustav; Woodley, John

    2015-01-01

    Biocatalytic oxidation reactions offer several important benefits such as regio- and stereoselectivity, avoiding the use of toxic metal based catalysts and replacing oxidizing reagents by allowing the use of oxygen. However, the development of biocatalytic oxidation processes is a complex task......-up is relatively straight forward (Gabelman and Hwang, 1999), and membrane contactors are implemented for various industrial applications (Klaassen et al., 2005)....

  10. An Integrated Decision Model for Evaluating Educational Web Sites from the Fuzzy Subjective and Objective Perspectives

    Science.gov (United States)

    Huang, Tony Cheng-Kui; Huang, Chih-Hong

    2010-01-01

    With advances in information and network technologies, lots of data have been digitized to reveal information for users by the construction of Web sites. Unfortunately, they are both overloading and overlapping in Internet so that users cannot distinguish their quality. To address this issue in education, Hwang, Huang, and Tseng proposed a group…

  11. Asia Beyond the Border: Physical Geography - Central and Northeastern Asia -

    Science.gov (United States)

    1961-03-21

    Shan: the kiang species ( Equus hemionus kiang). Forest hoofed animals are characteristic only for the western and northern mountain groups which are...severe winter olinate or its hot suremers» ’ „ ,, . •The Hwang Ho has a bread a»4>in S»*** a low vamy «»«»S tee sand and alluvial desert

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Eul-Won Hwang1 Kyung-A Kim1 Soo-Chul Park2 Mi-Jeong Jeong2 Myung-Ok Byun2 Hawk-Bin Kwon1. Division of Applied Biological Sciences, Sunmoon University, Asan, 336-708, Korea; Abiotic and Biotic Stress Team, National Institute of Agricultural Biotechnology, Suwon 441-707, Korea ...

  13. A Study of GaAsSb Nanowires by Molecular Beam Epitaxy for Near IR Applications

    Science.gov (United States)

    2015-09-18

    Mosca, S. Franchi , P. Frigeri, E. Gombia, A. Carnera, M. Peroni, Mater. Science and Eng. B 80, 32 (2001). 1 Appendix C Pavan...Hossain N, Hild K, Jin S R, Sweeney S J, Yu S Q, Johnson S R, Ding D and Zhang Y H 2010 Photonics Global Conference IEEE 1 14 [3] Hwang J S, Tsai J T, Su

  14. Anti-inflammatory Effects of Magnolia sieboldii Extract in ...

    African Journals Online (AJOL)

    Hao Li4 and Kang-Duk Choi1*. 1Genomic ... Methods: The whole plant of M. sieboldii was extracted with methanol at room temperature. The in vitro ... action of M. sieboldii in inflammation. Magnolia ..... Shih HC, Hwang TL, Chen HC, Kuo PC, Lee EJ, Lee. KH, Wu TS. ... Fu JY, Masferrer JL, Seibert K, Raz A, Needleman P.

  15. Hydrophilic Cucurbit[7]uril-Pseudorotaxane-Anchored-Monolayer-Protected Gold Nanorods

    Science.gov (United States)

    2013-03-20

    FULL PAPER DOI:10.1002/ejic.201300010 Hydrophilic Cucurbit[7]uril-Pseudorotaxane-Anchored- Monolayer-Protected Gold Nanorods Xiang Ma,[a] Yuhua Xue... Cao , Q. Wang, H. Tian, Chem. Commun. 2011, 47, 3559–3561. [8] a) I. Hwang, K. Baek, M. Jung, Y. Kim, K. M. Park, D. W. Lee, N. Selvapalam, K. Kim, J. Am

  16. Reconstituting the Social: Transforming Institutions and Emerging Forms of Knowledge-Making in Korea, Late Nineteenth Century to 1945

    Directory of Open Access Journals (Sweden)

    John DiMoia

    2016-09-01

    Full Text Available Kyung Moon Hwang, Rationalizing Korea: The Rise of the Modern State, 1894-1945. University of California Press, 2015. 416 pp. $75 (cloth; $35 (paper/e-book. Theodore Jun Yoo, It's Madness: The Politics of Mental Health in Colonial Korea. University of California Press, 2016. 248 pp. $65 (cloth/e-book.

  17. Beyond Authoritarian Personality: The Culture-Inclusive Theory of Chinese Authoritarian Orientation.

    Science.gov (United States)

    Chien, Chin-Lung

    2016-01-01

    In a dyad interaction, respecting and obeying those with high status (authority) is highly valued in Chinese societies. Regarding explicit behaviors, Chinese people usually show respect to and obey authority, which we call authoritarian orientation. Previous literature has indicated that Chinese people have a high degree of authoritarian personality, which was considered a national character. However, under Confucian relationalism (Hwang, 2012a), authoritarian orientation is basically an ethical issue, and thus, should not be reduced to the contention of authoritarian personality. Based on Yang's (1993) indigenous conceptualization, Chien (2013) took an emic bottom-up approach to construct an indigenous model of Chinese authoritarian orientation; it represents a "culture-inclusive theory." However, Chien's model lacks the role of agency or intentionality. To resolve this issue and to achieve the epistemological goal of indigenous psychology (that is, "one mind, many mentalities"), this paper took the "cultural system approach" (Hwang, 2015b) to construct a culture-inclusive theory of authoritarian orientation in order to represent the universal mind of human beings as well as the mentalities of people in a particular culture. Two theories that reflect the universal mind, the "Face and Favor model" (Hwang, 1987) and the "Mandala Model of Self" (Hwang, 2011a,c), were used as analytical frameworks for interpreting Chien's original model. The process of constructing the culture-inclusive theory of authoritarian orientation may represent a paradigm for the construction of indigenous culture-inclusive theories while inspiring further development. Some future research directions are proposed herein.

  18. Rediscovering Paideia and the Meaning of a Scholarly Career: Rejoinder to "Identifying Research Topic Development in Business and Management Education Research Using Legitimation Code Theory"

    Science.gov (United States)

    Antonacopoulou, Elena P.

    2016-01-01

    In "Identifying Research Topic Development in Business and Management Education Research Using Legitimation Code Theory," authors J.B. Arbaugh, Charles J. Fornaciari, and Alvin Hwang ("Journal of Management Education," December 2016 vol. 40 no. 6 p654-691, see EJ1118407) used citation analysis to track the development of…

  19. Ask the Business School Ranking Media to Walk Their Talk: Rejoinder to "Identifying Research Topic Development in Business and Management Education Research Using Legitimation Code Theory"

    Science.gov (United States)

    Pearce, Jone L.

    2016-01-01

    Arbaugh, Fornaciari, and Hwang (2016) are to be commended for undertaking two worthy tasks: demonstrating the value of citation counts in the business and management education (BME) field and attracting new scholars to the field by drawing on rigorous citation analyses. In this commentary, Jone Pearce first addresses the use of citation counts in…

  20. Economic Education within the BME Research Community: Rejoinder to "Identifying Research Topic Development in Business and Management Education Research Using Legitimation Code Theory"

    Science.gov (United States)

    Asarta, Carlos J.

    2016-01-01

    Carlos Asarta comments here that Arbaugh, Fornaciari, and Hwang (2016) are to be commended for their work ("Identifying Research Topic Development in Business and Management Education Research Using Legitimation Code Theory" "Journal of Management Education," Dec 2016, see EJ1118407). Asarta says that they make several…

  1. Structural, magnetic and magnetotransport properties of La0⋅7 ...

    Indian Academy of Sciences (India)

    Unknown

    Carvajal 1993 Physica B192 55. 11. Randaelli P G, Marezio M, Hwang H Y and Cheong. S-W 1996 J. Solid State Chem. 122 444. 12. Barnabé A, Millange F, Maignan A, Hervieu M,. Raveau B, Van Tendeloo G and Laffez P 1998 Chem. Mater.

  2. Synthesis of exfoliated PA66 nanocomposites via interfacial ...

    Indian Academy of Sciences (India)

    [24] Kang M, Myung S J and Jin H J 2006 Polymer 47 3961. [25] Haggenmueller R ... [32] Shirali H, Rafizadeh M and Taromi F A 2014 J. Compos. Mater. 48 301 ... [37] Hwang S Y, Khaydarov A A, Park J Y, Yoo E S and Im S S. 2011 Macromol.

  3. Fermentation characteristics of Korean pear (Pyrus pyrifolia Nakai ...

    African Journals Online (AJOL)

    USER

    2010-08-30

    Aug 30, 2010 ... Dong Chung Kim1, Hee Jeong Chae2,3 and Man-Jin In1*. 1Department of Human ... 0.3% proteins and 0.2% lipids (Hwang and Park, 2006). It is primarily consumed as ..... Khan SH, Ansari FA (2007). Probiotics – the friendly ...

  4. Catalytic wet peroxide oxidation of formic acid in wastewater with ...

    African Journals Online (AJOL)

    2016-07-03

    Jul 3, 2016 ... The reaction was monitored by ATR FTIR by following the disappearance of the O-H ..... of hydrogen peroxide than other iron ions such as FeCl2, FeCl3, ..... HWANG D-S, LEE E-H, KIM K-W, LEE K-I and PARK S-J (1999).

  5. Field implementation of fiber-reinforced polymer (FRP) deck panels.

    Science.gov (United States)

    2017-06-01

    Jeffery S. Volz, S.E., P.E., Ph.D., Kamal H. Khayat, PhD, P.Eng. http://orcid.org/0000-0003-1431-0715, Soo Duck Hwang, Ph.D. http://orcid.org/0000-0003-2178-1531, Hesham Tuwair, Ph.D., Jonathan T. Drury, Amy S. Crone : Although still in their infancy...

  6. 76 FR 41258 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-07-13

    ... Individual), Gediminas Garmus, Member/Manager. Application Type: New OFF License. World Logistics USA, Inc... at (202) 523-5843 or by e-mail at [email protected] . 3 Plus Logistics Co. dba Touchdown Freight Co. (NVO... Logistics, Inc. (NVO), 3120 Via Mondo, Rancho Dominguez, CA 90220. Officer: Simon Hwang, President/CEO...

  7. The Relative Effectiveness of Digital Game-Based Learning Types in English as a Foreign Language Setting: A Meta-Analysis

    Science.gov (United States)

    Chiu, Yi-hui; Kao, Chian-wen; Reynolds, Barry Lee

    2012-01-01

    During the past 10 years, the number of digital game-based learning (DGBL) studies has significantly increased (Hwang & Wu, 2012). DGBL is generally found to be positive over traditional instruction (Liao, 2010) and it has had great impact on education (Prensky, 2001). The DGBL effectiveness, however, might vary according to subjects taught or…

  8. Genetic diversity and germplasm resource research on tung tree ...

    African Journals Online (AJOL)

    SERVER

    2008-04-17

    Apr 17, 2008 ... a 2720 Thermal Cycler under the following cycle profile: 5 min at. 94oC ; followed by 45 cycles of 45 s at 94oC , 1 min at annealing temperature (Ta, depend on primers used, Table 2), .... chrome b5 to Either Endoplasmic Reticulum or Mitochondria. Plant. Cell. 16: 3002-3019. Henderson MP, Hwang YT, ...

  9. YY1 Control of AID Dependent Lymphomagenesis

    Science.gov (United States)

    2016-09-01

    Molecular Devices). Immunohistochemistry Spleens from NP-CGG immunized mice were collected on day 14 and immersed in O.C.T. (Tissue Tek), flash frozen using...70. Yildirim E, et al. (2013) Xist RNA is a potent suppressor of hematologic cancer in mice. Cell 152(4):727–742. 71. Hwang SH, et al. (2012) B cell

  10. Life or death? A Physiogenomic Approach to Understand Individual Variation in Responses to Hemorrhagic Shock

    Science.gov (United States)

    2011-01-01

    2009, 234, 1503-1510. [34] Fang, J. F.; Shih, L. Y.; Yuan, K. C.; Fang, K. Y.; Hwang, T. L.; Hsieh, S. Y. Proteomic analysis of post-hemorrhagic...resistant and susceptible barley lines during interaction with the powdery mildew fungus . Plant Mol. Biol., 2001, 47, 739-748. [96] Harris, N. S

  11. 他尊感情と自尊感情が自己表現に与える影響

    OpenAIRE

    石川, 満佐育; 石隈, 利紀; 濱口, 佳和

    2005-01-01

    This study was conducted to investigate the effects of other-esteem and self-esteem on self-expression. Study 1, drawing on the concept of other-esteem advocated by Hwang (2000), developed a scale of other-esteem consists ...

  12. Complete Genome Sequence of Alkaliphilus metalliredigens Strain QYMF, an Alkaliphilic and Metal-Reducing Bacterium Isolated from Borax-Contaminated Leachate Ponds.

    Science.gov (United States)

    Hwang, C; Copeland, A; Lucas, S; Lapidus, A; Barry, K; Detter, J C; Glavina Del Rio, T; Hammon, N; Israni, S; Dalin, E; Tice, H; Pitluck, S; Chertkov, O; Brettin, T; Bruce, D; Han, C; Schmutz, J; Larimer, F; Land, M L; Hauser, L; Kyrpides, N; Mikhailova, N; Ye, Q; Zhou, J; Richardson, P; Fields, M W

    2016-11-03

    Alkaliphilus metalliredigens strain QYMF is an anaerobic, alkaliphilic, and metal-reducing bacterium associated with phylum Firmicutes QYMF was isolated from alkaline borax leachate ponds. The genome sequence will help elucidate the role of metal-reducing microorganisms under alkaline environments, a capability that is not commonly observed in metal respiring-microorganisms. Copyright © 2016 Hwang et al.

  13. Arhitektuurimuuseum vaatab Aasiasse / Kim Sung Hong ; intervjueerinud Karin Hallas-Murula

    Index Scriptorium Estoniae

    Kim Sung Hong

    2009-01-01

    Näituse kuraatori Kim Sung Hongiga 21. aprillini Eesti Arhitektuurimuuseumis avatud Lõuna-Korea kaasaegse arhitektuuri näitusest "Megacity network" ("Megalinna võrgustik"), Korea arhitektuurist, arhitektidest, muinsuskaitsest ja avalikust ruumist. Näituse kujundas Hwang Doo Jin

  14. Silver-Doping Effects and Photostructural Transformation in Evaporated AS2S3 Thin Films.

    Science.gov (United States)

    1982-02-16

    of evaporated silver halide films. The details of the preparation of evaporated films of silver halides are reported by Junod at. al. (41 ) The...1980). 40. M.S. Chang, N.D. Hwang, J.T. Chen, Extended Abstr. Electrochem. Soc., 80-1, 692, (1980). 41. P. Junod , N. MHediger, B. Kilchoy. R. Steiger

  15. A Theory of the Origin of the State

    Science.gov (United States)

    Carneiro, Robert L.

    1970-01-01

    Suggests that states evolve in response to ecological or social circumscription, or resource concentration. When dense populations develop, fighting over land forces loser into political subordination or incorporation. This modification of coercive theories explain lack of state in Amazon basin and origin of Inca, Maya, Hwang Valley states.…

  16. Duality between SU(N)k and SU(k)N WZW models

    International Nuclear Information System (INIS)

    Naculich, S.G.; Schnitzer, H.J.

    1990-01-01

    We exhibit a duality of the SU(N) k WZW model under interchange of the group parameter N and the level k. The primary fields of SU(N) k and SU(k) N are related by transposition of their associated Young tableaux. The holomorphic blocks of the four-point functions of the primary fields are in one-to-one correspondence, and satisfy orthogonality and completeness relations with respect to one another. We derive these relations through a path integral realization of the SU(N) k WZW model in terms of a theory of constrained Dirac fermions. (orig.)

  17. Little strings, quasi-topological sigma model on loop group, and toroidal Lie algebras

    Directory of Open Access Journals (Sweden)

    Meer Ashwinkumar

    2018-03-01

    Full Text Available We study the ground states and left-excited states of the Ak−1 N=(2,0 little string theory. Via a theorem by Atiyah [1], these sectors can be captured by a supersymmetric nonlinear sigma model on CP1 with target space the based loop group of SU(k. The ground states, described by L2-cohomology classes, form modules over an affine Lie algebra, while the left-excited states, described by chiral differential operators, form modules over a toroidal Lie algebra. We also apply our results to analyze the 1/2 and 1/4 BPS sectors of the M5-brane worldvolume theory.

  18. Journal Of The Korean Hydrogen Energy Society 2

    International Nuclear Information System (INIS)

    2001-11-01

    This book deals with studies such as new ball-milled metal hydride electrode for rechargeable batteries by Noh, Haki; Park, Chung Nyeon, hydrogen absorption by laves phase related BCC solid solution alloys by Etsuo Akiba. The hydrogen absorption kinetics in very thin pd film by Cho, Young Sin; Lee, Jong Suk; Kim, Chang Won. The effect of the ceramic precipitates on the hydrogen solubility in pd alloys by Koh, Je Mann; Lee, Kil Hong; Bada, Seung Nam; Noh, Hak, and AC impedance study of the electrochemical behavior of hydrogen, Oxygen gas mixture at nafion, catalyst electrode interface by Song, S. M and Lee, W. M.

  19. Marketing strategies oh the companies delivering internet services

    OpenAIRE

    Egidė-Patašienė, Ilona

    2009-01-01

    Pirmoje darbo dalyje buvo įvertinta ir nagrinėta įmonės strateginė orientacija, strateginio planavimo ir valdymo esmė, apibrėžta marketingo strategijos samprata, pateikti pagrindiniai marketingo strategijų tipai, priklausomai nuo įmonės užimamos pozicijos rinkoje, konkurentų ir kt. veiksnių bei nusakytas teorinis marketingo strategijos įmonėje sukūrimo modelis. Antroje darbo dalyje, remiantis moksliniais straipsniais bei rastais pavyzdžiais mokslinėje marketingo literatūroje, buvo įvertinti m...

  20. Modelling of the impact of advertising source on advertising effectiveness : theoretical insights

    OpenAIRE

    Pilelienė, Lina; Grigaliūnaitė, Viktorija

    2015-01-01

    Straipsnyje analizuojami reklaminės žinutės šaltinio įtakos reklamos efektyvumui teoriniai aspektai. Reklama yra viena dažniausių marketingo komunikacijos priemonių, todėl reklamos efektyvumo didinimas tampa siektinu daugelio organizacijų tikslu, padedančiu įgyvendinti marketingo komunikacijos tikslus. Kadangi reklaminės žinutės šaltinis yra vienas svarbiausių reklamos elementų, straipsnio tikslu tapo teorinio reklaminės žinutės šaltinio įtakos reklamos efektyvumui modelio sukūrimas. Siekiant...

  1. Bagatellid : maailm / Nele-Eva Steinfeld, Ivo Heinloo

    Index Scriptorium Estoniae

    Steinfeld, Nele-Eva

    2011-01-01

    Muusikasõnumeid maailmast: 14. Tšaikovski nimelisest konkursist. Daniel Barenboim tõstetakse rüütliseisusesse. Orkestrist I, Culture Orchestra. Charles Dutoit plaanib luua Lõuna- ja Põhja-Koread ühendava orkestri. Lahkus Josef Suk. Seiji Ozawa pälvis Praemium Imperiale auhinna. Cardiffi lauljate konkursi võitis Valentina Nafornita. Lahkus Nikolai Petrov. Venetsueelas lööb laineid noor dirigent Jose Omar Davila. "Jazzkaare" täht Brass Jaw sai Suurbritannias suure tunnustuse osaliseks. Põhjamaade Nõukogu muusikaauhinna teenis Mats Gustafsson. Black Eyed Peas paneb pillid kotti. Kuuba kitarrist Manuel Galban surnud. Eesti on Tšehhi jazziraadio fookuses

  2. Multifunctional Poly(2,5-benzimidazole)/Carbon Nanotube Composite Films

    Science.gov (United States)

    2010-01-01

    Multifunctional Poly(2,5- benzimidazole )/Carbon Nanotube Composite Films JI-YE KANG,1 SOO-MI EO,1 IN-YUP JEON,1 YEONG SUK CHOI,2 LOON-SENG TAN,3 JONG...molecular-weight poly(2,5- benzimidazole ) (ABPBI). ABPBI/carbon nanotube (CNT) compo- sites were prepared via in situ polymerization of the AB-monomer in the...polymerization; multiwalled carbon nanotube (MWCNT); nano- composites; poly(2,5- benzimidazole ); (ABPBI); polycondensa- tion; poly(phosphoric acid); single-walled

  3. Development and Application of Decision Aid for Tactical Control of Battlefield Operations: Bibliographic Sort of the Decision Aiding Literature

    Science.gov (United States)

    1973-12-01

    IN~CI MURRAY A IL1QEINFU PROC RILEVANT TI) MILl CUMMAND SukVIY bIb E.SDTDR 63 349 2 1 MILLIH L n juDu.E VALUE JV1,GMT bASIL . TCTC CUMMAND !.Yb ORG BLH...DEC MAp. INTLRREL AND Aba =AS BLH bC! 61 6 23 1 UkAVL5 8 L. AND DEC MAW. VAR= INTERREL 61MM PLRb D15 Ab 60O 20 41291 tjA(6LIARDI ON MAN COMP RELs

  4. The application of coronal scattering measurements to solar radio bursts

    International Nuclear Information System (INIS)

    Bradford, H.M.

    1980-01-01

    The interpretation of ground based observations of solar 'plasma frequency' radio bursts has been hampered in the past by an insufficient knowledge of coronal scattering by density inhomogeneities close to the Sun. Calculations based on measuurements of the angular broadening of natural radio sources, and Woo's 1975 measurement of the angular broadening of the telemetry carrier by Helios I near occultation (Woo, 1978), indicate that plasma frequency solar bursts should undergo considerable scattering, at least near the maximum of the sunspot cycle. The calculated displacements of the apparent positions of the bursts are about equal to the observed displacements which have been attributed to the bursts occurring in dense streamers. In order to obtain more scattering data close to the Sun, interferometer measurements of the angular broadening of spacecraft signals are planned, and the important contribution which could be made with large dishes is discussed. (Auth.)

  5. Patient-reported outcome and risk of revision after shoulder replacement for osteoarthritis

    DEFF Research Database (Denmark)

    Rasmussen, Jeppe V; Polk, Anne; Brorson, Stig

    2014-01-01

    PURPOSE: We used patient-reported outcome and risk of revision to compare hemiarthroplasty (HA) with total shoulder arthroplasty (TSA) and stemmed hemiarthroplasty (SHA) with resurfacing hemiarthroplasty (RHA) in patients with glenohumeral osteoarthritis. PATIENTS AND METHODS: We included all...... of presentation, the raw scores were converted to a percentage of the maximum score. Revision rates were calculated by checking reported revisions to the DSR until December 2011. WOOS and risk of revision were adjusted for age, sex, previous surgery, and type of osteoarthritis. RESULTS: There were 113 TSAs...... and 1096 HAs (837 RHAs and 259 SHAs). Patients treated with TSA generally had a better WOOS, exceeding the predefined minimal clinically important difference, at 1 year (mean difference 10, p

  6. Outcome, revision rate and indication for revision following resurfacing hemiarthroplasty for osteoarthritis of the shoulder

    DEFF Research Database (Denmark)

    Rasmussen, J V; Polk, A; Sorensen, A K

    2014-01-01

    In this study, we evaluated patient-reported outcomes, the rate of revision and the indications for revision following resurfacing hemiarthroplasty of the shoulder in patients with osteoarthritis. All patients with osteoarthritis who underwent primary resurfacing hemiarthroplasty and reported...... to the Danish Shoulder Arthroplasty Registry (DSR), between January 2006 and December 2010 were included. There were 772 patients (837 arthroplasties) in the study. The Western Ontario Osteoarthritis of the Shoulder (WOOS) index was used to evaluate patient-reported outcome 12 months (10 to 14) post......-operatively. The rates of revision were calculated from the revisions reported to the DSR up to December 2011 and by checking deaths with the Danish National Register of Persons. A complete questionnaire was returned by 688 patients (82.2%). The mean WOOS was 67 (0 to 100). A total of 63 hemiarthroplasties (7...

  7. The Danish Shoulder Arthroplasty Registry: clinical outcome and short-term survival of 2,137 primary shoulder replacements

    DEFF Research Database (Denmark)

    Rasmussen, Jeppe; Jakobsen, John; Brorson, Stig

    2012-01-01

    The Danish Shoulder Arthroplasty Registry (DSR) was established in 2004. Data are reported electronically by the surgeons. Patient-reported outcome is collected 10-14 months postoperatively using the Western Ontario osteoarthritis of the shoulder index (WOOS). 2,137 primary shoulder arthroplasties...... (70% women) were reported to the registry between January 2006 and December 2008. Mean age at surgery was 69 years (SD 12). The most common indications were a displaced proximal humeral fracture (54%) or osteoarthritis (30%). 61% were stemmed hemiarthroplasties, 28% resurfacing hemiarthroplasties, 8......% reverse shoulder arthroplasties, and 3% total arthroplasties. Median WOOS was 59% (IQR: 37-82). 5% had been revised by the end of June 2010. The most frequent indications for revision were dislocation or glenoid attrition....

  8. Army Profession: How Effective Leadership Reinforces an Ethos of Trust

    Science.gov (United States)

    2016-06-10

    34 Won-Woo Park and Sangyun Kim, “The Need of Leader-Subordinate Reciprocal Dyadic Trust to Build the Subordinate’s Trust in the...Behavior: Communication and Understanding in Relationships, eds. A. G. Athos and J. J. Gabarro (Englewood Cliffs, NJ: Prentice-Hall, 1978), 290-303...the trust recommendations were senior Army leader strategic communication programs, trust development in doctrine, and making trust a topic for all

  9. BCP selector valves and limit switches

    International Nuclear Information System (INIS)

    Rippy, G.L.

    1995-01-01

    This Acceptance Test Procedure (ATP) has been prepared to demonstrate that the Electrical/Instrumentation systems for the BCP stream function as required by project criteria. Specifically, the test will verify the operation of the solenoid valves and associated limit switches installed for the BCP portion of W-OO7H. This equipment is part of the B-Plant Process Condensate Treatment Facility

  10. A Continuum Mechanical Approach to Geodesics in Shape Space

    Science.gov (United States)

    2010-01-01

    mean curvature flow equation. Calc. Var., 3:253–271, 1995. [30] Siddharth Manay, Daniel Cremers , Byung-Woo Hong, Anthony J. Yezzi, and Stefano Soatto...P. W. Michor and D. Mumford. Riemannian geometries on spaces of plane curves. J. Eur. Math. Soc., 8:1–48, 2006. 37 [33] Peter W. Michor, David ... Cremers . Shape matching by variational computation of geodesics on a manifold. In Pattern Recognition, LNCS 4174, pages 142–151, 2006. [38] P

  11. Nonequilibrium Phase Transitions Associated with DNA Replication

    Science.gov (United States)

    2011-02-11

    polymerases) catalyzing the growth of a DNA primer strand (the nascent chain of nucleotides complementary to the template strand) based on the Watson ...the fraction (error rate) of monomers for which y, where y is the correct Watson - Crick complementary base of , can be obtained by ¼ X...Nonequilibrium Phase Transitions Associated with DNA Replication Hyung-June Woo* and Anders Wallqvist Biotechnology High Performance Computing

  12. Improving Protection against Viral Aerosols Through Development of Novel Decontamination Methods and Characterization of Viral Aerosol

    Science.gov (United States)

    2012-04-01

    mixing DAS (Granular form, Sigma–Aldrich, P9265) with deionized (DI) water and then cooked at 95 o C for 2 hrs, as described in Song et al. (2009...from sneezing or coughing. Details of the recipe for artificial saliva are reported in Woo et al. (2010). Experimental Method A schematic diagram of...microwave. ** Polyacrylonitrile ( PAN ) and cross-linked PAN nanofiber filter were tested and the

  13. Index of Submarine Medical Officer’s Qualification Theses 1944-1974

    Science.gov (United States)

    1976-04-01

    USING HYPOTHERMIA AND HYPERBARIC CXYGENATI 1972-3011 0 A CASE REPO+ HYPOBARIC HYPOXIA ABOARD A SUBMERGED SUBMARINE 1972-0014 THE EFFECTS OF ACUTE HYPOXIA...G009 LEVEL. VENTILATORY DYNAMICS UNDER HYPERBARIC STATES.= SUBMARINE MEDICAL QUALIFICATION THESES U. So NAVAL SJBMARINE MEDICAL CENTER SUBMARINE BASE...CONNECTICUT. 23 OCT 62 StJRL ____________ 1962-0019 WOO3D W.- - ____ VENTILATORY DYNAMICS UNDER HYPERBARIC STATES.= SUBMARINE MEDICAL QUALIFICATION THESES

  14. Omega-3 fatty acid supplementation can improve both symptoms and signs of dry eye disease

    OpenAIRE

    Kwon,Jae-Woo; Han,Sang Beom

    2017-01-01

    Jae-Woo Kwon,1 Sang Beom Han2 1Department of Internal Medicine, 2Department of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, South Korea We read with great interest the article by Gatell-Tortajada1 entitled “Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prosp...

  15. DARPA Quantum Network Testbed

    Science.gov (United States)

    2007-07-01

    Antonio Bovino, Pietro Varisco, Anna Maria Colla, Giuseppe Castagnoli, Giovanni Di Giuseppe and Alexander V. Sergienko “Effective Fiber-Coupling of...Giovanni Di Giuseppe Brian Imhausen Harvard University Teammate John Myers Tai Wu Leo Donnelly NIST Teammate Sae Woo Nam Bob Schwall Robert...A. M. Colla, G. Castagnoli, G. Di Giuseppe, and A. V. Sergienko, “Practical Quantum Key Distribution Using Polarization Entangled States

  16. Microwave-Irradiation-Assisted HVAC Filtration for Inactivation of Viral Aerosols (Postprint)

    Science.gov (United States)

    2012-02-01

    Baggiani, A. and Senesi, S. (2004). Effect of Microwave Radiation on Bacillus subtilis Spores . J. Appl. Microbiol. 97: 1220–1227. Damit, B., Lee, C.N...AFRL-RX-TY-TP-2012-0020 MICROWAVE-IRRADIATION-ASSISTED HVAC FILTRATION FOR INACTIVATION OF VIRAL AEROSOLS POSTPRINT Myung-Heui Woo and...12-APR-2011 -- 11-DEC-2011 Microwave Irradiation-Assisted HVAC Filtration for Inactivation of Viral Aerosols (POSTPRINT) FA8650-06-C-5913 0602102F

  17. Boomers versus Millennials: Online Media Influence on Media Performance and Candidate Evaluations

    OpenAIRE

    Terri Towner; Caroline Lego Munoz

    2016-01-01

    Facebook posts, YouTube videos, tweets and wooing political bloggers have become standard practice in marketing political campaigns. Research has demonstrated the effect of new media on a host of politically-related behavior, including political participation, knowledge acquisition, group formation and self-efficacy. Yet, issues related to media trust, media performance and candidate evaluations have not been fully explored. In addition, much of the political marketing research looks exclusiv...

  18. A General Explanation-Based Learning Mechanism and Its Application to Narrative Understanding.

    Science.gov (United States)

    1987-12-01

    Forbus. and Alan Frisch for also serving on my inal committee and providing helpful comments. . .- Woo- Kyoung Ahn for being a great cognitive science...up the Michelin guide and got in her car. When the system processes the action that Willa has picked up the Michelin guide. it considers that tae next...following is the new Kveah narrative written by one subject in the instance group. Bill. Kim . John and Marv were all business associates. Bill wanted

  19. JPRS Report, Near East & South Asia, India

    Science.gov (United States)

    1991-09-04

    short-term gains. It would sustained minor injuries . One of the ULFA militants was call for quite a change in attitude on the part of Indian also injured...central committee who assist the politburo. They are Mr woo him into the cabinet since his mentor Vasantdada Prakash Karat and Mr Sitaram Yachuri from Delhi...The market share of the Indian yarn was too low for it REP licence system. Success in eliminating quantity to cause material injury . restrictions will

  20. Operation CROSSROADS-1946

    Science.gov (United States)

    1984-05-01

    uate and reduce nonradiological hazards to boarding parties. Hazards thdt had to be addressed included falling objects, slippery decks, weak ladders...8217., Woo a 001401 0 *#fgay It, 1 At 1 11-101-46 1, 11I...’ WO, Wal.l g’".l Will I I IL) A’e , elm ..l O f i -o S itlitim 1 t)aIII’) 11- 11.0m 11r tl ai f If

  1. The woollen system- development and basic principles

    CSIR Research Space (South Africa)

    Van der Merwe, JP

    1984-03-01

    Full Text Available .................. ..................... 4.9 Fibre transfer between swift and doffer ..................................... 4.10 WooUencondensing ............................ 4.10.1 Ring doffer condensers 4.10.2 Tape condensers.... For the dusting or shaking process a double-cylinder opening machine is often used, as shown in Figure 2. Sand, dirt and dust are removed by the rotating spiked beaters which heat the wool against the screens at the bottom of the machine. Fig. 2 - Doubk...

  2. Navy Carrier Battle Groups: The Structure and Affordability of the Future Force

    Science.gov (United States)

    1993-02-01

    Embassy, Tokyo, Japan U.S. Embassy, Kuala Lumpur, Malaysia U.S. Embassy, Singapore U.S. Embassy, Bangkok, Thailand U.S. Embassy, Ankara, Turkey U.S...Ministry of Foreign Affairs Malaysia Institute of Strategic and International Studies, Kuala Lumpur University of Malaysia , Kuala Lumpur Singapore...1591 1992 Calendar year Mediterraniean Sao - Western Pacific Ocean " Nestl Indian 0asan/Arabian Seam WOO I Total Note: Because theso deployment levels

  3. A Study on the Armillary Spheres of the Confucianists in Joseon Dynasty

    Science.gov (United States)

    Lee, Yong Sam; Kim, Sang Hyuk; Lee, Min Soo; Jeong, Jang Hae

    2010-12-01

    Armillary sphere, generally known as, not only astronomical instrument for observing astronomical phenomena but also symbolizes the royal authority and royal political ideology which is based on Confucianism. Among the well-reputed Confucian scholars were built their own armillary spheres. However, these armillary spheres which exist are damaged and most of parts of its have been lost. We analyzed and measured the remnants of armillary spheres which were made by Toegye Lee Hwang, Uam Song Si-Yeol and Goedam Bae Sang-Yeol who were well-reputed Confucian scholars in Joseon Dynasty, and have been executed the restorations of Toegye Lee Hwang and Song Si-Yeols armillary sphere based on the drawings which were drawn as the original form by analysis and measurement of its remnants.

  4. A Study on the Armillary Spheres of the Confucianists in Joseon Dynasty

    Directory of Open Access Journals (Sweden)

    Yong Sam Lee

    2010-12-01

    Full Text Available Armillary sphere, generally known as, not only astronomical instrument for observing astronomical phenomena but also symbolizes the royal authority and royal political ideology which is based on Confucianism. Among the well-reputed Confucian scholars were built their own armillary spheres. However, these armillary spheres which exist are damaged and most of parts of its have been lost. We analyzed and measured the remnants of armillary spheres which were made by Toegye Lee Hwang, Uam Song Si-Yeol and Goedam Bae Sang-Yeol who were well-reputed Confucian scholars in Joseon Dynasty, and have been executed the restorations of Toegye Lee Hwang and Song Si-Yeols armillary sphere based on the drawings which were drawn as the original form by analysis and measurement of its remnants.

  5. Estimation of parameters of interior permanent magnet synchronous motors

    International Nuclear Information System (INIS)

    Hwang, C.C.; Chang, S.M.; Pan, C.T.; Chang, T.Y.

    2002-01-01

    This paper presents a magnetic circuit model to the estimation of machine parameters of an interior permanent magnet synchronous machine. It extends the earlier work of Hwang and Cho that focused mainly on the magnetic aspects of motor design. The proposed model used to calculate EMF, d- and q-axis reactances. These calculations are compared to those from finite element analysis and measurement with good agreement

  6. X-Integrationism for Chinese Indigenous Management Research

    DEFF Research Database (Denmark)

    Li, Xin

    2015-01-01

    Regarding philosophical foundation of Chinese indigenous management research, Prof. Kwang Kuo Hwang of Taiwan University and Prof. Peter P. Li of Copenhagen Business School have contradictory judgments. Their opinions represent two opposite poles. This paper tries to offer a middle route between ...... rooted in China and the West, such as, Chinese Yin Yang thinking, Daoism, Confucianism, Bohr’s complementarity principle, and Hegel’s dialectic logic, this paper tries to construct the daoliology, epistemology and methodology of Chinese indigenous management research....

  7. Escape and transmission probabilities in cylindrical geometry

    International Nuclear Information System (INIS)

    Bjerke, M.A.

    1980-01-01

    An improved technique for the generation of escape and transmission probabilities in cylindrical geometry was applied to the existing resonance cross section processing code ROLAIDS. The algorithm of Hwang and Toppel, [ANL-FRA-TM-118] (with modifications) was employed. The probabilities generated were found to be as accurate as those given by the method previously applied in ROLAIDS, while requiring much less computer core storage and CPU time

  8. High Efficiency Flexible Battery Based on Graphene-carbon Nanotube Hybrid Structure

    Science.gov (United States)

    2015-02-26

    Choi, Carbon 77 1065(2014) 2. Hierarchical NiCo2O4@nickel-sulfide nanoplate arrays for high-performance supercapacitors , Chu Q, Wang W, Wang X...Graphene:Synthesis and Applications, CRC Press ISBN-10: 1439861870 | ISBN-13: 978-1439861875 | Publication Date: October 11, 2011 Handbook of Nanomaterials ...Properties, Carbon Nanomaterials : a review, Nitin Choudhary, Sookhyun Hwang, Wonbong Choi, Springer (2013) 15. Santanu Das and Wonbong Choi, Graphene

  9. Fulltext PDF

    Indian Academy of Sciences (India)

    2017-09-09

    Sep 9, 2017 ... 102 134105-1. [15] Scott J C and Bozano L D 2007 Adv. Mater. 19 1452. [16] Yang Y C, Pan F, Liu Q, Liu M and Zeng F 2009 Nano Lett. 9. 1636. [17] Lee D, Choi H J, Sim H J, Choi D, Hwang H, Lee M J et al. 2005 IEEE Electron Dev. Lett. 26 719. [18] Guan W H, Long S B, Jia R and Liu M 2007 Appl. Phys.

  10. Multifunctional Nanotechnology Research

    Science.gov (United States)

    2016-03-01

    MULTIFUNCTIONAL NANOTECHNOLOGY RESEARCH MARCH 2016 INTERIM TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED STINFO COPY AIR...REPORT 3. DATES COVERED (From - To) JAN 2015 – JAN 2016 4. TITLE AND SUBTITLE MULTIFUNCTIONAL NANOTECHNOLOGY RESEARCH 5a. CONTRACT NUMBER IN-HOUSE...H. Yoon, and C. S. Hwang, “Electrically configurable electroforming and bipolar resistive switching in Pt/TiO2/Pt structures.,” Nanotechnology , vol

  11. Understanding Social Media Entrepreneurship to promote innovation within SMEs

    OpenAIRE

    Beckinsale, M. J. J.; Romano, S.

    2017-01-01

    TOPIC Social media has transformed the delivery, structure and availability of information, putting the once capital-intensive role of broadcasting (Simmons et al., 2011) within the reach of individuals. New interactions are generated by social media technologies (Hanse et al., 2010); connectivity is enhanced by human networks (Hwang and Kim, 2015). Blackshaw & Nazaro (2006, cited in Xiang and Gretzel 2010) define Social Media as Internet-based applications that carry consumer-generated co...

  12. Protocol for a between-group experimental study examining cultural differences in emotion processing between Malay and Caucasian adults with and without major depressive disorder

    OpenAIRE

    Mohan, S N; Mukhtar, F; Jobson, L

    2016-01-01

    Introduction Depression is a mood disorder that affects a significant proportion of the population worldwide. In Malaysia and Australia, the number of people diagnosed with depression is on the rise. It has been found that impairments in emotion processing and emotion regulation play a role in the development and maintenance of depression. This study is based on Matsumoto and Hwang's biocultural model of emotion and Triandis' Subjective Culture model. It aims to investigate the influence of c...

  13. Nonlinear Photonic Systems for V- and W-Band Antenna Remoting Applications

    Science.gov (United States)

    2016-10-22

    AFRL-AFOSR-JP-TR-2016-0088 Nonlinear Photonic Systems for V- and W-Band Antenna Remoting Applications Sheng-Kwang Hwang NATIONAL CHENG KUNG...2016 2. REPORT TYPE Final 3. DATES COVERED (From - To) 26 May 2015 to 25 May 2016 4. TITLE AND SUBTITLE Nonlinear Photonic Systems for V- and W-Band...TERMS nonlinear, photonic , antenna, remote, microwave, amplification, bandwith, modulation 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT SAR

  14. Gauge-invariant gravitational wave modes in pre-big bang cosmology

    International Nuclear Information System (INIS)

    Faraoni, Valerio

    2010-01-01

    The t<0 branch of pre-big bang cosmological scenarios is subject to a gravitational wave instability. The unstable behaviour of tensor perturbations is derived in a very simple way in Hwang's covariant and gauge-invariant formalism developed for extended theories of gravity. A simple interpretation of this instability as the effect of an ''antifriction'' is given, and it is argued that a universe must eventually enter the expanding phase. (orig.)

  15. Analysis of Free-Space Coupling to Photonic Lanterns in the Presence of Tilt Errors

    Science.gov (United States)

    2017-05-01

    lantern-based coherent lidar system,” Opt. Express, vol. 23, no. 4, pp. 5312–5316, Feb 2015. [5] J. Montoya , C. Aleshire, C. Hwang, N. K. Fontaine, A...Velázquez- Benı́tez, D. H . Martz, T. Fan, and D. Ripin, “Photonic lantern adaptive spatial mode control in lma fiber amplifiers,” Opt. Express, vol

  16. Modulation of T-Cell Activation in an Experimental Model of Mammary Carcinoma

    Science.gov (United States)

    1999-07-01

    nitrosourea (MNU) mutagenesis system suggested that rejection of SM1 might protect against subsequent mutagenic treatment. However, those studies suffered...R.C., R.C. Osborn, S.M. Swanson, R. Sakthivel, S.I. Hwang, S. Miyamoto, and S. Nandi. 1992. Incidence of c-Ki-ras activation in N-methyl-N- nitrosourea ...against melanocyte antigens (36, 37). Genes encod- Our previous studies have revealed that tumor rejection ing proteins associated with pigment synthesis

  17. Unmanned Three-Environment Vehicle (U3V)

    Science.gov (United States)

    2014-08-01

    College London (UCL) was used [3]. In addition, the conceptual sizing processes described by Raymer [4] and Corning [5] provided some early assistance...underwater operation. As a result of the UAV survey, a basic aircraft sizing iteration using Raymer [4] could be conducted. This is detailed in Appendix B... Robert Deon (Canadian Navy Officer – CISD) attended appraisal reviews and provided technical insight throughout. Young Hwang (Structures and Composites

  18. Mineralization of TNT, RDX, and By-Products in an Anaerobic Granular Activated Carbon-Fluidized Bed Reactor

    Science.gov (United States)

    2003-04-01

    pipe fitters and safety personnel who constructed and installed the system. CERL personnel include Don Cropek, Pat Kemme, Neil Adrian and Clint Arnett...al. (2000), demonstrated the sequential conversion of the nitro-groups to amino-groups in TNT degradation, and Adrian and Sutherland , 1998...dinitrotoluene extended the research to TNT, RDX and pinkwater (Adrian and Sutherland , 1998, VanderLoop et al., 1998 and Hwang et al., 2000). Initial pilot

  19. Estimation of parameters of interior permanent magnet synchronous motors

    CERN Document Server

    Hwang, C C; Pan, C T; Chang, T Y

    2002-01-01

    This paper presents a magnetic circuit model to the estimation of machine parameters of an interior permanent magnet synchronous machine. It extends the earlier work of Hwang and Cho that focused mainly on the magnetic aspects of motor design. The proposed model used to calculate EMF, d- and q-axis reactances. These calculations are compared to those from finite element analysis and measurement with good agreement.

  20. Spain in South Ukraine NPP

    International Nuclear Information System (INIS)

    Ibanez, M.

    1994-01-01

    A Technical Assistance Protocol was signed between the Governments of the GIS and the Commission of the European Union (CEU) on August 2, 1991 and this was the starting point of the TACIS program. In this article, the activities described are those related to the TACIS-92/93/94 on site technical assistance to South Ukraine NPP (SUK NPP). Within the scope of the TACIS 92 Program the CEU and the Ukrainian Authorities agreed a list of projects to be implemented at South Ukraine NPP with the aim to improve the operational safety of the plant. This part of the program is called TACIS 92 on-site activities. The total budget allocated to these projects is a MECU. The European Union ''utility'' selected to lead this program at South Ukraine NPP was UNESA and the first contract to cover our activities was signed in July 1993 between the CEU (Mr. Pablo Benavides) and UNESA (Mr. Pedro Rivero). The projects will be implemented at SUK NPP but according to the contract UNESA is ''The Consultant'' and GOSKOMATON (The Ukrainian Sate Committee on Nuclear Power Utilization) is the ''Recipient Institution''. (Author)

  1. Versenyképesség a szakirodalomban – A fogalmi megközelítések összegzése és elemzése (I. rész)

    OpenAIRE

    Somogyi, Márta

    2009-01-01

    A szerző jelen tanulmányában a versenyképesség fogalma körül kialakult megközelítéseket veszi sorra és hasonlítja össze. A versenyképességi fogalmakat, értelmezéseket – a lehetőségekhez képest – időbeli kialakulásuk, megfogalmazásuk sorrendjében mutatja be; ez a megközelítés ugyanis lehetőséget biztosít arra, hogy a fogalom időbeli alakulását (fejlődését, bővülését) is nyomon követhesse. Teszi mindezt azzal a szándékkal, hogy a megismert fogalmak, megközelítési módok és értelmezés...

  2. Post-death cloning of endangered Jeju black cattle (Korean native cattle): fertility and serum chemistry in a cloned bull and cow and their offspring.

    Science.gov (United States)

    Kim, Eun Young; Song, Dong Hwan; Park, Min Jee; Park, Hyo Young; Lee, Seung Eun; Choi, Hyun Yong; Moon, Jeremiah Jiman; Kim, Young Hoon; Mun, Seong Ho; Oh, Chang Eon; Ko, Moon Suck; Lee, Dong Sun; Riu, Key Zung; Park, Se Pill

    2013-12-17

    To preserve Jeju black cattle (JBC; endangered native Korean cattle), a pair of cattle, namely a post-death cloned JBC bull and cow, were produced by somatic cell nuclear transfer (SCNT) in a previous study. In the present study, we examined the in vitro fertilization and reproductive potentials of these post-death cloned animals. Sperm motility, in vitro fertilization and developmental capacity were examined in a post-death cloned bull (Heuk Oll Dolee) and an extinct nuclear donor bull (BK94-13). We assessed reproductive ability in another post-death cloned cow (Heuk Woo Sunee) using cloned sperm for artificial insemination (AI). There were no differences in sperm motility or developmental potential of in vitro fertilized embryos between the post-death cloned bull and its extinct nuclear donor bull; however, the embryo development ratio was slightly higher in the cloned sperm group than in the nuclear donor sperm group. After one attempt at AI, the post-death cloned JBC cow became pregnant, and gestation proceeded normally until day 287. From this post-death cloned sire and dam, a JBC male calf (Heuk Woo Dolee) was delivered naturally (weight, 25 kg). The genetic paternity/maternity of the cloned JBC bull and cow with regard to their offspring was confirmed using International Society for Animal Genetics standard microsatellite markers. Presently, Heuk Woo Dolee is 5 months of age and growing normally. In addition, there were no significant differences in blood chemistry among the post-death cloned JBC bull, the cow, their offspring and cattle bred by AI. This is the first report showing that a pair of cattle, namely, a post-death cloned JBC bull and cow, had normal fertility. Therefore, SCNT can be used effectively to increase the population of endangered JBC.

  3. The use of wood waste for energy production

    International Nuclear Information System (INIS)

    Karlopoulos, E.; Pavloudakis, F.

    1999-01-01

    The paper presents some technical aspects and management issues of wood waste reuse end disposal. It refers to the Greek and European legislation which determines the framework for rational and environmental friendly practices for woos waste management. It refers also to the wood waste classification systems and the currently applied methods of wood waste disposal and reuse. Emphasis is given to the wood waste-to-energy conversion system, particularly to the pretreatment requirements, the combustion techniques, and the environmental constrains. Finally, the decision making process for the investments in the wood waste firing thermal units is discussed

  4. JPRS Report, Near East & South Asia, Israel

    Science.gov (United States)

    1991-08-26

    parties it tried to woo into a coalition last Kohen didn’t care about the brand name. She had just year. In the end, the Likud’s offers won the day, so...is actually being Therefore, his depiction as a martyr, a victim, and an conducted among the Arabs themselves, and its peak underdog is nonsense...the army and The group was housed in buildings in an abandoned one of them was a combat officer in the Armoured military camp from the period of the

  5. Advanced Technology for Ultra-Low Power System-on-Chip (SoC)

    Science.gov (United States)

    2017-06-01

    was proposed for lower power applications with Ioff=10pA/μm and VDD=0.5V. In this project, the optimized structure shows great potential in both Lg...AFRL-RY-WP-TR-2017-0115 ADVANCED TECHNOLOGY FOR ULTRA-LOW POWER SYSTEM-ON-CHIP (SoC) Jason Woo, Weicong Li, and Peng Lu University of California...September 2015 – 31 March 2017 4. TITLE AND SUBTITLE ADVANCED TECHNOLOGY FOR ULTRA-LOW POWER SYSTEM-ON- CHIP (SoC) 5a. CONTRACT NUMBER FA8650-15-1-7574 5b

  6. Biological age as a health index for mortality and major age-related disease incidence in Koreans: National Health Insurance Service – Health screening 11-year follow-up study

    OpenAIRE

    Kang,Young Gon; Suh,Eunkyung; Lee,Jae-woo; Kim,Dong Wook; Cho,Kyung Hee; Bae,Chul-Young

    2018-01-01

    Young Gon Kang,1 Eunkyung Suh,2 Jae-woo Lee,3 Dong Wook Kim,4 Kyung Hee Cho,5 Chul-Young Bae1 1Department of R&D, MediAge Research Center, Seongnam, Republic of South Korea; 2Department of Family Medicine, College of Medicine, CHA University, Chaum, Seoul, Republic of South Korea; 3Department of Family Medicine, College of Medicine, Chungbuk National University, Cheongju, Republic of South Korea; 4Department of Policy Research Affairs, National Health Insurance Service Ilsan Hospital...

  7. Needs Assessment to Define the Training Requirements for a Basic Skills Education Program (BSEP) Curriculum Development. Revision.

    Science.gov (United States)

    1984-04-01

    MW1 zm~woo 0 /4 ==W a.. w Z 3 OU. 3 C M p. i 40..U - w W -- l2 L ccU= 1 0.-- r U)_.O I- ~ I-1 ZI 4 C :x U z WX-L U ZZ 4 0Z LL - ac z3 _ uj.- 0 ~ f3 LU D...opeC/cdswoeap e to the TPA-2 form and remort,-a:c 70- :o -e 7P,-3 and Knowledge Analysis formns and reports. To acca -%-- Ce :ns cn’-r’ge, task anal’,s

  8. Linkage relationship between semi-dwarfing gene sd-1 and gene for grain shattering in rice

    International Nuclear Information System (INIS)

    Oba, S.; Kikuchi, F.

    1990-01-01

    Full text: Most semidwarf rice cultivars carry the same gene sd-1. We observed an association between semi-dwarfness and grain shattering in isogenic lines carrying sd-1 from different sources in the background of the Japanese tall cultivar 'Norin 28'. The shattering was found to be caused by a single recessive gene, sh-2, linked to the sd-1 locus. The shattering gene seems to have been transmitted to many semi-dwarf cultivars together with sd-1, not only from 'Dee-geo-woo-gen' but also from the indica-cultivar 'Ai-jio-nan-te' and the japonica cultivar 'Shiranui'. (author)

  9. Seks ja töö / Andres Maimik

    Index Scriptorium Estoniae

    Maimik, Andres, 1970-

    2000-01-01

    Filmifestivalil "Armastus ja Anarhia" ("Rakkautta & Anarkiaa") 21.09.- 01.10. nähtud filmidest : Rosa von Praudheimi eluloofilm "Einstein of Sex", Julien Temple dokumentaalfilm "The Filth and the Fury", Virginie Despentes ja Coralie Trinh Thi "Baise moi!" ("Vägista mind!"), Catherine Breillat "Une vraie Jeune Fille" ("Päris noor tüdruk"), Francois Ozoni Rainer Werner Fassbinderi näidendi järgi tehtud film "Gouttes d'eau sur pierres brulantes" ("Veetilgad põlevatel kividel"), Jang Sun Woo "Gojimal" ("Valed") ja Laurent Cantet' "Ressources humaines" ("Inimressursid")

  10. Ospreys Use Bald Eagle Nests in Chesapeake Bay Area

    OpenAIRE

    Therres, Glenn D.; Chandler, Sheri K.

    1993-01-01

    Ospreys (Pandion haliaetus) and Bald Eagles (Haliaeetus leucocephalus) share similar breeding habitat in the Chesapeake Bay area and elsewhere. The nests of these species are similar in size and appearance. Ospreys typically build large stick nests in dead trees or on man-made structures (C.J. Henny et al. 1974, Chesapeake Sci. 15:125-133; A.F. Poole 1989, Ospreys: a natural and unnatural history, Cambridge Univ. Press, NY), while Bald Eagles usually build larger nests in live trees (P.B. Woo...

  11. Pink electrons, anyone?

    International Nuclear Information System (INIS)

    McCaughey, John.

    1997-01-01

    The deregulated electric power industry in the United States is undergoing a radical change in marketing emphasis more familiar to consumers of branded products such as soft drinks. In attempts to woo customers from other companies, utilities are beginning to market a ''company image'' offering lower prices, better products (i.e. other household services such as telephone and cable television) and improved provision levels of customer services. The price of the product, in this case electric power, has been shown to be much more likely to persuade a consumer to shift supplier than any existing level of customer satisfaction. (UK)

  12. Electronic Materials and Applications 2014 (Abstracts)

    Science.gov (United States)

    2015-04-02

    electric fatigue at TU Darmstadt (SFB595) . In Germany he served the Deutsche Forschungsgemeinschaft (DFG) a four-year term as speaker of the review...epitaxial La-doped PZT films at low concentrations of La-doping M. Hordagoda*, D. Mukherjee, University of South Florida, USA; D. Ghosh, J. Jones...S1-P001-2014) Effect of viscosity and thickness in PZT - PZNN tape casting process for energy harvesting system D. Song*, M. Woo, D. Cho, T. Sung

  13. Korean Reunification: The Implications for Regional Security

    Science.gov (United States)

    1994-06-01

    But this conflict was caused by external factors. In reality it is a combined internal and external problem. 10 Ibid., pp. 208-209, King Sejong and...was Ancient Chosen which was led by the legendary founder King Tan’gun- Wanggom. He established a tribal country called Kochoson in 4 Han, Woo-Keun...During the Warring period in China, between the 6th century and 221 B.C., Kochoson confronted several ancient Chinese states, such as Yen( King Chao 312-279

  14. Pain: a distributed brain information network?

    Directory of Open Access Journals (Sweden)

    Hiroaki Mano

    2015-01-01

    Full Text Available Understanding how pain is processed in the brain has been an enduring puzzle, because there doesn't appear to be a single "pain cortex" that directly codes the subjective perception of pain. An emerging concept is that, instead, pain might emerge from the coordinated activity of an integrated brain network. In support of this view, Woo and colleagues present evidence that distinct brain networks support the subjective changes in pain that result from nociceptive input and self-directed cognitive modulation. This evidence for the sensitivity of distinct neural subsystems to different aspects of pain opens up the way to more formal computational network theories of pain.

  15. Fatigue life of automotive rubber jounce bumper

    International Nuclear Information System (INIS)

    Sidhu, R S; Ali, Aidy

    2010-01-01

    It is evident that most rubber components in the automotive industry are subjected to repetitive loading. Vigorous research is needed towards improving the safety and reliability of the components. The study was done on an automotive rubber jounce bumper with a rubber hardness of 60 IRHD. The test was conducted in displacement-controlled environment under compressive load. The existing models by Kim, Harbour, Woo and Li were adopted to predict the fatigue life. The experimental results show strong similarities with the predicted models.

  16. Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects

    OpenAIRE

    Kang,Woo Youl; Seong,Sook Jin; Ohk,Boram; Gwon,Mi-Ri; Kim,Bo Kyung; La,Sookie; Kim,Hyun-Ju; Cho,Seungil; Yoon,Young-Ran; Yang,Dong Heon; Lee,Hae Won

    2018-01-01

    Woo Youl Kang,1,2,* Sook Jin Seong,1,* Boram Ohk,1,2 Mi-Ri Gwon,1,3 Bo Kyung Kim,1,2 Sookie La,4 Hyun-Ju Kim,3 Seungil Cho,1 Young-Ran Yoon,1,2 Dong Heon Yang,5 Hae Won Lee1 1Clinical Trial Center, Kyungpook National University Hospital, Daegu, Republic of Korea; 2Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Kyungpook National University Graduate School, Daegu, Republic of Korea; 3Department of Molecular Medicine, Cell and Matrix Resear...

  17. Electric Power Research in 1991

    International Nuclear Information System (INIS)

    1991-05-01

    This book of contents are a study of desalination by Kim, Young Bu, a study on efficiency test for nuclear power security by Jo, Sung Je; Ann, Nam Sung; Kim, Ho Gi, augmentation of EMS and RYU by Jung, Tae Hoe; Shin, Young Chuel, research on application for electric cars by Yu, Ann Gue, practical use oft robot for nuclear industry by Woo, He Gone; Shin, Hen Beom, a study on the characteristics of coolant structure in generator by Choi, Beng Hwan; Song, Young Chel; Kim, Jong Hark, and research of penetration rate of appliances by Park, Hong Ho; Kim, Beng Cheal; Kim, Dong Hwen.

  18. X-Ray Absorption Spectroscopy of Uranium Dioxide

    Energy Technology Data Exchange (ETDEWEB)

    Tobin, J G

    2010-12-10

    After the CMMD Seminar by Sung Woo Yu on the subject of the x-ray spectroscopy of UO2, there arose some questions concerning the XAS of UO2. These questions can be distilled down to these three issues: (1) The validity of the data; (2) The monchromator energy calibration; and (3) The validity of XAS component of the figure shown. The following will be shown: (1) The data is valid; (2) It is possible to calibrate the monchromator; and (3) The XAS component of the above picture is correct. The remainder of this document is in three sections, corresponding to these three issues.

  19. Modulation of Estrogen-Depurinating DNA Adducts by Sulforaphane for Breast Cancer

    Science.gov (United States)

    2014-12-01

    system in cancers: stress response and anabolic metabolism. Front. Oncol., 2, 200. doi: 10.3389/ fonc.2012.00200. 20. Agyeman,S.A. et  al. (2012...to science education and young scientists. We look forward to working with you. Sincerely, Chuck  37 From: "Gary A. Lorigan...Drosophila," by Ki Moon Seong, Mira Yu, Kyu-Sun Lee, Young Woo Jin and Kyung J. Min, and for taking the time and effort to review this manuscript. Best

  20. Effects of adding nano-clay (montmorillonite) on performance of polyvinyl acetate (PVAc) and urea-formaldehyde (UF) adhesives in Carapa guianensis, a tropical species

    OpenAIRE

    Rodríguez-Zúñiga, Ana; Vega-Baudrit, José; Alvarez, Vera; Moya-Roque, Roger

    2015-01-01

    http://www.scopus.com/inward/record.url?eid=2-s2.0-84923601829&partnerID=40&md5=5c91a6df9afec4f33b7be09b86735a75 The aim of this study was to improve the bond strength resistance of polyvinyl acetate (PVAc) and urea-formaldehyde (UF) adhesives modified with nano-clay (montmorillonite) with a tropical species of wood known to exhibit adhesion related problems. These adhesives were evaluated with 1.0 and 1.5 wt% nano-clay concentrations with lap shear strength (SS), and the percentage of woo...

  1. Characterization of Si(100) homoepitaxy grown in the STM at low temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Grube, H. (Holger); Brown, G. W. (Geoffrey W.); Pomeroy, J. M. (Joshua M.); Hawley, M. E. (Marilyn E.)

    2002-01-01

    We explore the growth of low-temperature bulk-like Si(100) homoepitaxy with regard to microscopic surface roughness and defects We characterize films grown at different temperatures up to 500K in-situ by means of an effusion cell added to our UHVSTM. The development of novel architectures for future generation computers calls for high-quality homoepitaxial (WOO) grown at low temperature. Even though Si(100) can be grown crystalline up to a limited thickness: the microstructure reveals significant small-scale surface roughness and defects specific to low-temperature growth. Both can he detrimental to fabrication and operation of small-scale electronic devices.

  2. In case of criminal bankruptcy, should criminal actions of the perpetrator be additionally qualified as fraud against creditors?

    OpenAIRE

    Rimdžiūtė, Gita

    2017-01-01

    Magistro baigiamojo darbo tema – ar nusikalstamo bankroto atveju kaltininko veiksmai turi būti papildomai kvalifikuojami kaip sukčavimas kreditorių atžvilgiu? Ši tema šiai dienai aktuali, nes Lietuvoje pastebima, kaip daugėja nusikalstamų bankrotų, kurių siekiai būna ne tiksukelti bankrotą, bet kartu pasipelnyti bei išvengti susikaupusių skolų išieškojimo. Oatsiradusteismų praktikoje tokiai problemai pastebėtina, jog nėra vieningos nuomonės sprendžiant šiuos klausimus. Nusikalstamo bankro...

  3. SUSY WT identity in a lattice formulation of 2D N=(2,2) SYM

    International Nuclear Information System (INIS)

    Kadoh, Daisuke; Suzuki, Hiroshi

    2010-01-01

    We address some issues relating to a supersymmetric (SUSY) Ward-Takahashi (WT) identity in Sugino's lattice formulation of two-dimensional (2D) N=(2,2)SU(k) supersymmetric Yang-Mills theory (SYM). A perturbative argument shows that the SUSY WT identity in the continuum theory is reproduced in the continuum limit without any operator renormalization/mixing and tuning of lattice parameters. As application of the lattice SUSY WT identity, we show that a prescription for the Hamiltonian density in this lattice formulation, proposed by Kanamori, Sugino and Suzuki, is justified also from a perspective of an operator algebra among correctly-normalized supercurrents. We explicitly confirm the SUSY WT identity in the continuum limit to the first nontrivial order in a semi-perturbative expansion.

  4. Variation of Drying Strains between Tangential and Radial Directions in Asian White Birch

    Directory of Open Access Journals (Sweden)

    Zongying Fu

    2016-03-01

    Full Text Available In this study, wood disks of 30 mm in thickness cut from white birch (Betula platyphylla Suk logs were dried at a constant temperature (40 °C. The drying strains including practical shrinkage strain, elastic strain, viscoelastic creep strain and mechano-sorptive creep were measured both tangentially and radially. The effects of moisture content and radial position on each strain were also discussed qualitatively. Overall, the difference of the practical shrinkage strain between the tangential and radial directions was proportional to the distance from the pith. The tangential elastic strain and viscoelastic creep strain were higher than these strains in a radial direction, and they all decreased with the decrease of moisture content. Additionally, there were opposite mechano-sorptive creep between tangential and radial directions.

  5. The Role of Fatty Acid Metabolism in Estrogen Receptor Negative Breast Cancer

    Science.gov (United States)

    2015-11-01

    of a novel variant of isoform 6. Biochemistry 44 (5), 1635–1642. [31] Mashima T, Sato S, Okabe S, Miyata S, Matsuura M, Sugimoto Y, et al. (2009). Acyl... AMP and p38 mitogen-activated protein kinase.World J Gastroenterol 11, 2557–2563. [50] Sung KY, Hwang SY, Park MK, Bae HI, Kim WH, Kim JC, et al. (2003...Recombinant Long-Chain Rat Acyl-CoA Synthetase Isoforms 3 and 6: Identification of a Novel Variant of Isoform 6. Biochemistry 44: 1635-1642. doi:10.1021

  6. Cryptanalysis of quantum secret sharing based on GHZ states

    International Nuclear Information System (INIS)

    Liu Xiaofen; Pan Rijing

    2011-01-01

    In a recent paper (Hwang et al 2011 Phys. Scr. 83 045004), a subtle quantum secret sharing (QSS) protocol was proposed. One major advantage of this protocol is its high efficiency; that is, it is more efficient than other QSS protocols using the Greenberger-Horne-Zeilinger states. However, we analyzed the security of this protocol and found that it is insecure for one agent who may deduce half of the information about the deal's secret directly just by his/her piece of secret. Finally, a feasible improvement of this QSS protocol is put forward.

  7. Competition is not necessarily a barrier to community mobilisation among sex workers: an intervention planning assessment from Zimbabwe.

    Science.gov (United States)

    Mtetwa, Sibongile; Busza, Joanna; Davey, Calum; Wong-Gruenwald, Ramona; Cowan, Frances

    2015-08-16

    Community mobilization among female sex workers (SWs) is recognized as an effective strategy to empower SWs and increase their uptake of health services. Activities focus on increasing social cohesion between SWs by building trust, strengthening networks, and encouraging shared efforts for mutual gain. Several studies, however, suggest that high levels of interpersonal competition between SWs can pose a barrier to collective action and support. We conducted a study to examine levels of perceived competition between SWs in Mutare, Hwange and Victoria Falls in Zimbabwe in order to inform development of a community-based intervention for HIV prevention and treatment. This paper focuses on our qualitative findings and their implications for the design of HIV programming in the Zimbabwean context. Following a respondent driven sampling (RDS) survey, we explored issues related to social cohesion amongst SWs in Mutare, Hwange and Victoria Falls through in-depth interviews conducted with 22 SWs. Interviews examined dynamics of SWs' relationships and extent of social support, and were analyzed using thematic content analysis using the constant comparative method. Findings are contextualised against descriptive data extracted from the survey, which was analysed using Stata 12, adjusting for RDS. Across all sites, women described protecting each other at night, advising each other about violent or non-paying clients, and paying fines for each other following arrest. In Mutare, women gave additional examples, including physically attacking problem clients, treatment adherence support and shared saving schemes. However, interviews also highlighted fierce competition between women and deep mistrust. This reflects the reported mix of competition and support from the survey of 836 women (Mutare n = 370, Hwange n = 237, Victoria Falls n = 229). In Mutare, 92.8 % of SWs agreed there was a lot of competition; 87.9 % reported that SWs support each other. This contrasted

  8. Cloud Computing: Virtual Clusters, Data Security, and Disaster Recovery

    Science.gov (United States)

    Hwang, Kai

    Dr. Kai Hwang is a Professor of Electrical Engineering and Computer Science and Director of Internet and Cloud Computing Lab at the Univ. of Southern California (USC). He received the Ph.D. in Electrical Engineering and Computer Science from the Univ. of California, Berkeley. Prior to joining USC, he has taught at Purdue Univ. for many years. He has also served as a visiting Chair Professor at Minnesota, Hong Kong Univ., Zhejiang Univ., and Tsinghua Univ. He has published 8 books and over 210 scientific papers in computer science/engineering.

  9. [The amazing story of the fraudulent cloned embryos and what it tells us about science, technology, and the media].

    Science.gov (United States)

    Souza, Iara Maria de Almeida; Caitité, Amanda Muniz Logeto

    2010-06-01

    Based on news reports from Brazilian papers, the article examines the case of scientific fraud involving cloned embryos, committed by South Korean scientist Hwang. The media generally focus on the intellectual process of science, its discoveries, and the new possibilities it promises. In this case, however, science is shown the other way around, revealing a web that interweaves elements of a radically disparate nature, like the Korean government, researchers, tools, research funds, human eggs and funguses, scientific journals, among others. These ties are what make up science in practice, yet they only become visible in the media when there is tension between them and, in this case, when something illicit happens.

  10. Mode-Selective Amplification in a Large Mode Area Yb-Doped Fiber Using a Photonic Lantern

    Science.gov (United States)

    2016-05-15

    Montoya , C. Aleshire, C. Hwang, N. K. Fontaine, A. Velázquez- Benítez, D. H . Martz, T. Y. Fan, and D. Ripin, Opt. Express 24, 3405 (2016). 23. A. M...Stutzki, F. Jansen, H . J. Otto, O. Schmidt, T. Schreiber, J. Limpert, and A. Tünnermann, Opt. Express 19, 13218 (2011). 6. C. Jauregui, H . J. Otto, F...Express 21, 1944 (2013). 8. A. Smith and J. Smith, Opt. Express 19, 10180 (2011). 9. H . J. Otto, C. Jauregui, F. Stutzki, F. Jansen, J. Limpert, and A

  11. The rearrangement process in a two-stage broadcast switching network

    DEFF Research Database (Denmark)

    Jacobsen, Søren B.

    1988-01-01

    The rearrangement process in the two-stage broadcast switching network presented by F.K. Hwang and G.W. Richards (ibid., vol.COM-33, no.10, p.1025-1035, Oct. 1985) is considered. By defining a certain function it is possible to calculate an upper bound on the number of connections to be moved...... during a rearrangement. When each inlet channel appears twice, the maximum number of connections to be moved is found. For a special class of inlet assignment patterns in the case of which each inlet channel appears three times, the maximum number of connections to be moved is also found. In the general...

  12. Trapped Atoms in One-Dimensional Photonic Crystals

    Science.gov (United States)

    2013-08-09

    2002 J. Opt. Soc. Am. B 19 2052 [39] Koenderink A F, Kafesaki M, Soukoulis C M and Sandoghdar V 2006 J. Opt. Soc. Am. B 23 1196 [40] Manga Rao V S C...032509 [55] Hwang J K, Ryu H Y and Lee Y H 1999 Phys. Rev. B 60 4688–95 [56] Yao P, Manga Rao V S C and Hughes S 2010 Laser Photon. Rev. 4 499–516 New Journal of Physics 15 (2013) 083026 (http://www.njp.org/)

  13. Physico-chemical and antioxidant properties of four mango (Mangifera indica L.) cultivars in China.

    Science.gov (United States)

    Liu, Feng-Xia; Fu, Shu-Fang; Bi, Xiu-Fang; Chen, Fang; Liao, Xiao-Jun; Hu, Xiao-Song; Wu, Ji-Hong

    2013-05-01

    Four principal mango cultivars (Tainong No.1, Irwin, JinHwang and Keitt) grown in southern China were selected, and their physico-chemical and antioxidant properties were characterized and compared. Of all the four cultivars, Tainong No.1 had highest content of total phenols, ρ-coumaric acid, sinapic acid, quercetin, titratable acidity, citric acid, malic acid, fructose, higher antioxidant activities (DPPH, FRAP) and L(*), lower pH, PPO activity and individual weight. Keitt mangoes showed significantly (pmangoes exhibited significantly (pmango cultivars to be differentiated clearly based on all these physico-chemical and antioxidant properties determined in the study. Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. Cryptanalysis of quantum secret sharing based on GHZ states

    Energy Technology Data Exchange (ETDEWEB)

    Liu Xiaofen; Pan Rijing, E-mail: liuxiaofen23@fjnu.edu.cn [School of Mathematics and Computer Science, Fujian Normal University, Fuzhou 350007 (China); Key Laboratory of Network Security and Cryptography, Fujian Normal University, Fuzhou 350007 (China)

    2011-10-15

    In a recent paper (Hwang et al 2011 Phys. Scr. 83 045004), a subtle quantum secret sharing (QSS) protocol was proposed. One major advantage of this protocol is its high efficiency; that is, it is more efficient than other QSS protocols using the Greenberger-Horne-Zeilinger states. However, we analyzed the security of this protocol and found that it is insecure for one agent who may deduce half of the information about the deal's secret directly just by his/her piece of secret. Finally, a feasible improvement of this QSS protocol is put forward.

  15. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 7. Fairlane Gear, Incorporated-General Fiberglass Fabricators.

    Science.gov (United States)

    1987-01-01

    n " L(140(00 0 ( -00 (D -0 -i- F- C") (.1 I-- (0(0LJ I jInI x I.( < .41 000000000 0000 -100000 -10000 woo0 (0 00 000 0L j0 0000 I( < 4 InO 0000000...44 0 NO "(00-40-4_-4 MD -t ONj I4 NI" 000 ZO 0CD00) 00 (0 woo w0-4000000 F-0 GAO 0-14 (𔃾 00 0 0Cm) z1- 4 < Cm) I -in inin -0 01-(0 (00 01 rC- Cm) IC...I I at % - * 0- 1 02-lZ I Lw c4 r 4 4 jIN CJI-4 JINNNinN -tr(jJNM JINI #NI NINN -JIACINjNN NC\\N--INNN NN-4NN INIJ--N(, >WI -,I - - - - - nC lI MIIr)" l

  16. Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 12 (McFadden Jimmy, Portugal - NCR Japan LTD, Japan), FY1991

    Science.gov (United States)

    1991-01-01

    co0 Z1--.-0) ) Mm𔄁’ -4-4 0- HM. I 0O-4 H 0r- 01r- 01r- 01-, 0 000Cl0 C 1 -4 xo)0) -I qt4 od w -4 HO 00 0~ .0 00 Wix wOC L44 WJOU WM WOO IL H I0-4 H1...1 1000U -JO -JO -j 0CO4O .-. *O 2 2 0 0 0 Uf C 13 (N if wOO cW c.0OOL . O WO W’-- Lj4 L1.000 WeB $- wi - 3-0 - W0 U a 03 ILN (L 0.- CL- CL In0h...0 0 0 0 0 0 -400c -40 -40 m"- r.00 4N10 .4. 1 ge4 63 1I I 3 I I I 1- 3 60 000 0 00 0* W2 0 In 10 6 LUi I WIX >0 6 .- i.4 4 4 4 .4-4_ 4 ._4-IN -iN -IN

  17. Web-of-Objects (WoO)-based context aware emergency fire management systems for the Internet of Things.

    Science.gov (United States)

    Shamszaman, Zia Ush; Ara, Safina Showkat; Chong, Ilyoung; Jeong, Youn Kwae

    2014-02-13

    Recent advancements in the Internet of Things (IoT) and the Web of Things (WoT) accompany a smart life where real world objects, including sensing devices, are interconnected with each other. The Web representation of smart objects empowers innovative applications and services for various domains. To accelerate this approach, Web of Objects (WoO) focuses on the implementation aspects of bringing the assorted real world objects to the Web applications. In this paper; we propose an emergency fire management system in the WoO infrastructure. Consequently, we integrate the formation and management of Virtual Objects (ViO) which are derived from real world physical objects and are virtually connected with each other into the semantic ontology model. The charm of using the semantic ontology is that it allows information reusability, extensibility and interoperability, which enable ViOs to uphold orchestration, federation, collaboration and harmonization. Our system is context aware, as it receives contextual environmental information from distributed sensors and detects emergency situations. To handle a fire emergency, we present a decision support tool for the emergency fire management team. The previous fire incident log is the basis of the decision support system. A log repository collects all the emergency fire incident logs from ViOs and stores them in a repository.

  18. Web-of-Objects (WoO-Based Context Aware Emergency Fire Management Systems for the Internet of Things

    Directory of Open Access Journals (Sweden)

    Zia Ush Shamszaman

    2014-02-01

    Full Text Available Recent advancements in the Internet of Things (IoT and the Web of Things (WoT accompany a smart life where real world objects, including sensing devices, are interconnected with each other. The Web representation of smart objects empowers innovative applications and services for various domains. To accelerate this approach, Web of Objects (WoO focuses on the implementation aspects of bringing the assorted real world objects to the Web applications. In this paper; we propose an emergency fire management system in the WoO infrastructure. Consequently, we integrate the formation and management of Virtual Objects (ViO which are derived from real world physical objects and are virtually connected with each other into the semantic ontology model. The charm of using the semantic ontology is that it allows information reusability, extensibility and interoperability, which enable ViOs to uphold orchestration, federation, collaboration and harmonization. Our system is context aware, as it receives contextual environmental information from distributed sensors and detects emergency situations. To handle a fire emergency, we present a decision support tool for the emergency fire management team. The previous fire incident log is the basis of the decision support system. A log repository collects all the emergency fire incident logs from ViOs and stores them in a repository.

  19. Web-of-Objects (WoO)-Based Context Aware Emergency Fire Management Systems for the Internet of Things

    Science.gov (United States)

    Shamszaman, Zia Ush; Ara, Safina Showkat; Chong, Ilyoung; Jeong, Youn Kwae

    2014-01-01

    Recent advancements in the Internet of Things (IoT) and the Web of Things (WoT) accompany a smart life where real world objects, including sensing devices, are interconnected with each other. The Web representation of smart objects empowers innovative applications and services for various domains. To accelerate this approach, Web of Objects (WoO) focuses on the implementation aspects of bringing the assorted real world objects to the Web applications. In this paper; we propose an emergency fire management system in the WoO infrastructure. Consequently, we integrate the formation and management of Virtual Objects (ViO) which are derived from real world physical objects and are virtually connected with each other into the semantic ontology model. The charm of using the semantic ontology is that it allows information reusability, extensibility and interoperability, which enable ViOs to uphold orchestration, federation, collaboration and harmonization. Our system is context aware, as it receives contextual environmental information from distributed sensors and detects emergency situations. To handle a fire emergency, we present a decision support tool for the emergency fire management team. The previous fire incident log is the basis of the decision support system. A log repository collects all the emergency fire incident logs from ViOs and stores them in a repository. PMID:24531299

  20. Effect of self-interstitial diffusion anisotropy in electron-irradiated zirconium: A cluster dynamics modeling

    International Nuclear Information System (INIS)

    Christien, F.; Barbu, A.

    2005-01-01

    A model based on the cluster dynamics approach was proposed in [A. Hardouin Duparc, C. Moingeon, N. Smetniansky-de-Grande, A. Barbu, J. Nucl. Mater. 302 (2002) 143] to describe point defect agglomeration in metals under irradiation. This model is restricted to materials where point defect diffusion is isotropic and is thus not applicable to anisotropic metals such as zirconium. Following the approach proposed by Woo [C.H. Woo, J. Nucl. Mater. 159 (1988) 237], we extended in this work the model to the case where self-interstitial atoms (SIA) diffusion is anisotropic. The model was then applied to the loop microstructure evolution of a zirconium thin foil irradiated with electrons in a high-voltage microscope. First, the inputs were validated by comparing the numerical results with Hellio et al. experimental results [C. Hellio, C.H. de Novion, L. Boulanger, J. Nucl. Mater. 159 (1988) 368]. Further calculations were made to evidence the effect of the thin foil orientation on the dislocation loop microstructure under irradiation. The result is that it is possible to reproduce for certain orientations the 'unexpected' vacancy loop growth experimentally observed in electron-irradiated zirconium [M. Griffiths, M.H. Loretto, R.E. Sallmann, J. Nucl. Mater. 115 (1983) 313; J. Nucl. Mater. 115 (1983) 323; Philos. Mag. A 49 (1984) 613]. This effect is directly linked to SIA diffusion anisotropy

  1. The Process of Self-Cultivation and the Mandala Model of the Self.

    Science.gov (United States)

    Wu, Meiyao

    2017-01-01

    In his Mandala model of the self, Taiwanese scholar Kwang-Kuo Hwang sees each human being as a combination or intersection of private individual and social person, and also of knowledge and action. To further elaborate the model-with a particular emphasis on teaching/learning, the development of the ideal self and spiritual transcendence-this article will explore the psychological process of self-cultivation in the light of traditional Confucian thinking, which means keeping a balance between inner/outer and self/other. The Neo-Confucian thinker Zhongsha Mou's theories of "the awareness of unexpected developments" and his meditation/cognitive thinking opposition will also be discussed. The analyzed sources will include the traditional Confucian classics (the Four Books and Liji, or Classic of Rites ) and especially the " Lessons for Learning ( Xue-Ji )" in the Classic of Rites ( Liji ), along with the relevant textual research. Based upon a cultural-semantic analysis of these classics as well as of Hwang's central ideas, the author attempts to further conceptualize the process of cultivating the ideal self in Confucian education.

  2. Efficient multiparty quantum-secret-sharing schemes

    International Nuclear Information System (INIS)

    Xiao Li; Deng Fuguo; Long Guilu; Pan Jianwei

    2004-01-01

    In this work, we generalize the quantum-secret-sharing scheme of Hillery, Buzek, and Berthiaume [Phys. Rev. A 59, 1829 (1999)] into arbitrary multiparties. Explicit expressions for the shared secret bit is given. It is shown that in the Hillery-Buzek-Berthiaume quantum-secret-sharing scheme the secret information is shared in the parity of binary strings formed by the measured outcomes of the participants. In addition, we have increased the efficiency of the quantum-secret-sharing scheme by generalizing two techniques from quantum key distribution. The favored-measuring-basis quantum-secret-sharing scheme is developed from the Lo-Chau-Ardehali technique [H. K. Lo, H. F. Chau, and M. Ardehali, e-print quant-ph/0011056] where all the participants choose their measuring-basis asymmetrically, and the measuring-basis-encrypted quantum-secret-sharing scheme is developed from the Hwang-Koh-Han technique [W. Y. Hwang, I. G. Koh, and Y. D. Han, Phys. Lett. A 244, 489 (1998)] where all participants choose their measuring basis according to a control key. Both schemes are asymptotically 100% in efficiency, hence nearly all the Greenberger-Horne-Zeilinger states in a quantum-secret-sharing process are used to generate shared secret information

  3. Default Spread dan Term Spread sebagai Variabel Proxy Siklus Bisnis pada Model Fama-French

    Directory of Open Access Journals (Sweden)

    Edwin Hendra

    2015-08-01

    Full Text Available This research aims to apply the Fama-French models and test the effect of alternative variable of bond yield spread, default spread (RBBB – RAAA and RAAA – RF, and the term spread (RSUN10-RSUN1, as proxy variables of the business cycle, in IDX stock data during 2005-2010. Four types of asset pricing models tested are Sharpe-Lintner CAPM, Fama-French models, Hwang et al.model, and hybrid model. The results showed that the size effect and value effect has an impact on excess stock returns. Slopes of market beta, SMB, and HML are more sensitive to stock big size and high B / M. Default spreads and term spreads in Hwang et al. model can explain the value effect, and weakly explain the size effect, meanwhile the power of explanation disappeared on Hybrid models. Based on the assessment adjusted R2 and the frequency of rejection of non-zero alpha, is found that the hybrid model is the most suitable model.  

  4. Revision of Eucorydia Hebard, 1929 from China, with notes on the genus and species worldwide (Blattodea, Corydioidea, Corydiidae)

    Science.gov (United States)

    Qiu, Lu; Che, Yan-Li; Wang, Zong-Qing

    2017-01-01

    Abstract The cockroach genus Eucorydia from China is revised. Five new species are described and illustrated: Eucorydia linglong sp. n., Eucorydia pilosa sp. n., Eucorydia splendida sp. n., Eucorydia guilinensis sp. n., and Eucorydia tangi sp. n.. Corydia purpuralis Kirby, 1903 and Eucorydia paucipilosa Woo, Guo & Feng, 1986 are confirmed to be junior synonyms of Eucorydia dasytoides (Walker, 1868). Eucorydia hilaris (Kirby, 1903) is newly recorded from China. This genus and currently known species from around the world are discussed. The status of Eucorydia maxwelli (Hanitsch, 1915) is revived. Corydia plagiata Walker, 1868 is confirmed to be a junior synonym of Eucorydia ornata (Saussure, 1864). A checklist, key, and photographs of members of this genus are provided. PMID:29187785

  5. Nanobiomaterials development and applications

    CERN Document Server

    Papaefthymiou-Davis, Georgia C

    2013-01-01

    Nanomaterials in Nanobiotechnologies: Preparation, Characterization, and ApplicationsBio-Inspired Magnetic NanoparticlesGeorgia C. Papaefthymiou and Eamonn DevlinNanoparticles for BioimagingHye Sun Park and Yong Taik LimBiomedical Applications of Dendrimer Porphyrin or PhthalocyanineWoo-Dong Jang and Won-Gun KohPolymeric Nanoparticles in Cancer TherapyHeebeom Koo, Ji Young Yhee, Ick Chan Kwon, Kwangmeyung Kim, and Ramesh SubbiahCarbon Nanotube BioconjugatesMonica Samal, Dong Kee Yi, and Shashadhar SamalBiocatalytic NanosystemsJaehong Lim and Su Seong LeeMagnetically Induced Hyperthermia for Biomedical ApplicationsMichael Fardis, Ioannis Rabias, Georgios Diamantopoulos, Eleni Karakosta, Danai Tsitrouli, Vassilios Tzitzios, and Georgios PapavassiliouSoft Block Nanobuilding: New Preparation Routes of Soft Nanomaterials Using BiomoleculesEngineered Biomolecules as NanomaterialsYun Jung Lee and Ki Tae NamNanomaterials and Bio-MEMS: Nano- and Microscale Hybridization of Materials and ApplicationsMicrofluidic-Based ...

  6. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1985. Part 10 (Hi Plains Supply - International Cnslt Eng Inc).

    Science.gov (United States)

    1985-01-01

    cccC’-4.4 J-4-4 0,30----44.4f. w I(0 .41 -0)0000000 (00000 0)0 0)0)00000000 0ɘ (0(0c, f6 (0 .4ICCCCC ACC 1 ococo w w Wc co 0 000 000 n o00000 0 o...W00O00000000 woo0 INNC 1(0 .41200000000 200000 zoo 200000000000 2000 2WW F.- Im "W ww ww 11C(UCAAAA -4U)nCh cnAA(A 0-4IACA C ACCA ACCWj IC(nC (n -4<< o󈧎

  7. All Prime Contract Awards by State or Country, Place, and Contractor, FY 85. Part 15 (Altus, Oklahoma - Zelienople, Pennsylvania).

    Science.gov (United States)

    1985-01-01

    Iso CM I m -4 0N 4 MNNNNNN"N-4-4 aN ION w O 40 UNNN liN 40.4 4 OR 60 4 14 .-4 -4 ..4 -4f -4 I-’ 1 0 0 0 0 0 0 0 0 0 -i aJC 0 4 1 4 i q--4-4--4 -- 4...4 azo azo ixN 0 .0 woo 000 0zo 01( C’) -I .4 0i~o x-0 0 4 N - ((0 04 03(0 ()I 1 -0 -4 0~00 x -0 0 04 " .(A 0 04 0.0 .4 0’( 4C I m i 41013 ə 3tr irn

  8. Progress in the exploitation of new dwarfing genes in Chinese rice breeding

    International Nuclear Information System (INIS)

    Zhu, L.H.; Xie, Z.Q.

    1990-01-01

    Full text: Use of dwarfing genes in rice breeding in China began in the late 1950's. Since then, the major source of dwarfism has been 'Ai-zi-Zhan' with a gene allelic to sd-1 from 'Dee-Geo-Woo-Gen'. Since the 1970's, Chinese rice breeders paid attention to exploring new dwarfing gene sources and these efforts resulted in at least 7 sources non-allelic to sd-1. The late indica variety 'Gui-Yang-Ai No. 1' possessing gene dg(t) or sdg[t) proved to be most promising. The new sources include mutants induced by irradiation in 'Nanjing 11' and 'Nanjing 15'. The new genes are integrated in breeding to further improve plant type and adaptability. (author)

  9. All Prime Contract Awards by State or Country, Place, and Contractor. Part 21 (Stafford Virginia-Yellowstone Park)

    Science.gov (United States)

    1990-01-01

    m a 04 R mca 40000~ woo moo" 00000 00M 4c00 Wix 40 40 ( .J 1 0.4 H Can -. 0w0M0 -if-. -.1O IT- ooo KA 21mAc) A 0 zo A Ian C. t- * 0.4 V .-. 4-4 oo...U0QO 04 a 0-4 .20 .. 0 Wa 0.40 M0 "on~ 00 >0 40 00D 200 60 web am UM 9 -460 04 o O U 0 Wal O 90 0 40a00 2 "- coW 04,-4 0. 0.4" M.’ M p orn coM U) ’ (A M

  10. Trypanosoma vivax infection dynamics in a cattle herd maintained in a transition area between Pantanal lowlands and highlands of Mato Grosso do Sul, Brazil Dinâmica de infecção de Trypanosoma vivax em rebanho bovino mantido numa área de transição entre o Pantanal e o planalto de Mato Grosso do Sul

    Directory of Open Access Journals (Sweden)

    Charles F. Martins

    2008-01-01

    Full Text Available Trypanosoma vivax outbreaks in beef cattle in the Pantanal region of Mato Grosso do Sul state, Brazil, causes relevant economical impact due to weight loss, abortion and mortality. Cattle moved from the Pantanal to adjacent areas of this ecosystem for breeding and fattening is a common feature. Therefore an epidemiological study on breeding cows in the transition area between Pantanal lowland and adjacent highlands of Mato Grosso do Sul was performed to determine the T. vivax infection dynamics and outbreak risk. Three experimental groups were formed: Group 1 consisted of cows parasitologically negative by the Woo test and in the enzyme-linked immunosorbent assay for T. vivax antibody detection (Tv-ELISA-Ab; Group 2 parasitologically negative and positive in the Tv-ELISA-Ab; and in Group 3 cows were parasitologically positive and with positive reactions in the Tv-ELISA-Ab. During 24 months, the cows' dislodgment between the above established groups was monitored by Woo test and Tv-ELISA-Ab exams. The tabanid population was also monitored and the highest number occurred during the rainy season. Although parasitemias were detected only in the first four samplings of the experimental period, the cows could be considered as trypanotolerant, because no clinical signs were observed. Despite the higher T. vivax incidence during the dry season, no disease symptoms were seen. Even though T. vivax epidemiological situation in the herd was characterized as endemic with seasonal variation, the probability of outbreaks was null within the conditions of the study.Surtos de Trypanosoma vivax em bovinos de corte do Pantanal foram responsáveis por relevante impacto econômico, devido a perda de peso, abortos e mortalidade. Um manejo comum é o deslocamento de bovinos do Pantanal baixo para áreas adjacentes desse ecosistema para reprodução e engorda. Por essa razão, foi efetuado um estudo epidemiológico em rebanho de vacas movidas para uma área de transi

  11. The Atacama Cosmology Telescope: The Receiver and Instrumentation

    Science.gov (United States)

    Swetz, D. S.; Ade, P. A. R.; Amiri, M.; Appel, J. W.; Burger, B.; Devlin, M. J.; Dicker, S. R.; Doriese, W. B.; Essinger-Hileman, T.; Fisher, R. P.; hide

    2010-01-01

    The Atacama Cosmology Telescope was designed to measure small-scale anisotropies in the Cosmic Microwave Background and detect galaxy clusters through the Sunyaev-Zel'dovich effect. The instrument is located on Cerro Taco in the Atacama Desert, at an altitude of 5190 meters. A six-met.er off-axis Gregorian telescope feeds a new type of cryogenic receiver, the Millimeter Bolometer Array Camera. The receiver features three WOO-element arrays of transition-edge sensor bolometers for observations at 148 GHz, 218 GHz, and 277 GHz. Each detector array is fed by free space mm-wave optics. Each frequency band has a field of view of approximately 22' x 26'. The telescope was commissioned in 2007 and has completed its third year of operations. We discuss the major components of the telescope, camera, and related systems, and summarize the instrument performance.

  12. Engineering design and economic evaluation of a family-sized biogas project in Nigeria

    International Nuclear Information System (INIS)

    Adeoti, O.; Ilori, M.O.; Oyebisi, T.O.; Adekoya, L.O.

    2000-01-01

    To woo householders into harnessing the cooking energy potential of biogas in order to solve the perennial cooking energy problems at household level in Nigeria, this paper carried out the engineering design requirement, and used the discounted cash flow micro-economic assessments to evaluate the 6.0 m 3 family-sized biogas project in Nigeria. The project has an initial investment cost of 41,088 Naira, annual expenditure of 5909 Naira and an annual benefit of 13,347 Naira. The NPV, IRR, B/C and payback period of financial analysis are 0.050 million Naira, 17.52%, 2.26 and 6.6 years respectively. This shows that the 6.0 m 3 family-sized biogas project using cattle dung as substrate in Nigeria has a good economic potential. (author)

  13. Development of a high-pressure compaction system for non-combustible solid waste

    International Nuclear Information System (INIS)

    Yogo, S.; Hata, T.; Torita, K.; Yamamoto, K.; Karita, Y.

    1989-01-01

    In recent years, nuclear power plants in Japan have been in search of a means to reduce the volume of non-combustible solid wastes and therefore the application of a high-pressure compaction system has been in demand. Most non-combustible solid wastes have been packed in 200-litre drums for storage and the situation requires a high-pressure compaction system designed exclusively for 200-litre drums. The authors have developed a high-pressure compaction system which compresses 200-litre drums filled with non-combustible solid wastes and packs them into new woo-litre drums efficiently. This paper reports the outline of this high-pressure compaction system and the results of the full-scale verification tests

  14. An Elastic-Plastic Finite Element Analysis of Notched Aluminum Panels.

    Science.gov (United States)

    1981-03-01

    ZL. 0j W 0 WOO0 U w~ZZ%"*Q’c-- aIIUX(>-’j...W * 4%eweJW W *CI W. 4 * Q ~7.j W I~7 b-.~ i i t~e W W 00I 20 ~ ~ ~ ~ ~ t 2: aZ2a... Zaw Z Nctl-l*Z.J ’Z...34 Q"-Z=LU. LLZZoUZO 000 uzm3- LCWIn 40 Wi 0 %no* 0-4 004 to O*tt) -0 *0a -Or (* 0 . tuN * *010 ("~o 0-t a%* n Inl *0 101o 0- W* *4 -d .. *..i -4.4 144

  15. THE WEDDING CEREMONY IN THE TRADITIONAL VILLAGES OF OLTENIA. PRELIMINARY RITES

    Directory of Open Access Journals (Sweden)

    Anca CEAUŞESCU

    2016-10-01

    Full Text Available Marriage is the second most significant moment from a man’s life, an event that gives the opportunity of a rich display of folkloric manifestations. The ceremonial complex of the wedding mark, in a festive manner, the passing to another social statute. In Oltenia, it generally has a unitary structure, with small individualising elements, from one village to the other. The nuptial ceremony also presents in its development the three categories of rites, specific to the passing rites, such are: preliminary, liminary, post-liminary. Therefore, the nuptial scenario includes the existence of new rules and a logical succession in the development of the sequences. In the present material, we are going to stop on the customs from the stage that precedes the nuptial ceremony (wooing, discussing the dowry of the girl, the engagement, trying to point towards few dominant element of the phenomenon.

  16. Spectral broadening of planetary radar signals by the solar wind

    International Nuclear Information System (INIS)

    Harmon, J.K.; Coles, W.A.

    1983-01-01

    The microturbulence spectrum of the solar wind is estimated using the spectral broadening of planetary radar signals. Observations were made with the two radars (12.6 cm and 70 cm) at Arecibo Observatory during the 1979 and 1981 superior conjunctions of Venus. These observations, which span the solar distance range of 5.4 to 25.5 R/sub sun/, are the first of their type to be reported. The data are consistent with earlier observations where comparisons can be made. The flattening of the high-frequency portion of the spectrum near the Sun reported by Woo and Armstrong is confirmed. In one case clear evidence for an inner scale in the vicinity of 2 km is found. Two transients, 1979 August 15 and 1981 April 24-25, with rather different characteristics were observed

  17. Official Guard and Reserve Manpower Strengths and Statistics: FY 1989 Summary

    Science.gov (United States)

    1989-01-01

    S0- 5.8 co It0. 0 m a* t7 N 𔃾 in o𔃾 t N o - n-K, 0 mI- IZ 0 N m i an N 0o cm a, . KZK UK 14i N~’ 47 𔃾 N 0’ 0 D- 0 00a, c KlS K K I NNN 7n 𔃾 𔃾 No...W C, 00C0F)a*P m 00 on 0..0.....P00Mlso0 do w .P- 638%1 P 1 KZK ~ ~ P)goMK II- .8 4N i 40. 8 4 I.5M!.4M0󈧣U . * . P) woo- 3. 30 K 30A- N C4 in4C i K

  18. High risk for revision after shoulder arthroplasty for failed osteosynthesis of proximal humeral fractures

    DEFF Research Database (Denmark)

    Kristensen, Marc Randall; Rasmussen, Jeppe Vejlgaard; Elmengaard, Brian

    2018-01-01

    Background and purpose - It is unclear whether previous osteosynthesis is a risk factor for inferior outcome following shoulder arthroplasty for a proximal humeral fracture. We used data from the Danish Shoulder Arthroplasty Registry (DSR) to examine this question. Patients and methods - All 285...... patients treated with a shoulder arthroplasty after failed osteosynthesis of a proximal humeral fracture reported to DSR from 2006 to 2013 were included. Each case was matched with 2 controls (570) treated with a primary shoulder arthroplasty for an acute proximal humeral fracture. Patient reported outcome...... for a shoulder arthroplasty after failed osteosynthesis was 2 with a primary arthroplasty for fracture as reference. In a separate analysis of patients treated by locking plate the mean WOOS was 46 (24), with a relative risk of revision at 1.5 with a primary arthroplasty as reference. Interpretation - Compared...

  19. Shock wave science and technology reference library

    CERN Document Server

    2009-01-01

    This book is the second of several volumes on solids in the Shock Wave Science and Technology Reference Library. These volumes are primarily concerned with high-pressure shock waves in solid media, including detonation and high-velocity impact and penetration events. Of the four extensive chapters in this volume, the first two describe the reactive behavior of condensed phase explosives, - Condensed-Phase Explosives: Shock Initiation and Detonation Phenomena (SA Sheffield and R Engelke) - First Principles Molecular Simulations of Energetic Materials at High-Pressures (F Zhang, S Alavi, and TK Woo), and the remaining two discuss the inert, mechanical response of solid materials. - Combined Compression and Shear Plane Waves (ZP Tang and JB Aidun), and - Dynamic Fragmentation of Solids (D Grady). All chapters are each self-contained, and can be read independently of each other. They offer a timely reference, for beginners as well as professional scientists and engineers, on the foundations of detonation phenomen...

  20. Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems

    Directory of Open Access Journals (Sweden)

    Jalani G

    2014-05-01

    Full Text Available Ghulam Jalani,* Chan Woo Jung,* Jae Sang Lee, Dong Woo Lim Department of Bionano Engineering, College of Engineering Sciences, Hanyang University, Education Research Industry Cluster at Ansan Campus, Ansan, South Korea*These authors contributed equally to this workAbstract: Stimuli-responsive, polymer-based nanostructures with anisotropic compartments are of great interest as advanced materials because they are capable of switching their shape via environmentally-triggered conformational changes, while maintaining discrete compartments. In this study, a new class of stimuli-responsive, anisotropic nanofiber scaffolds with physically and chemically distinct compartments was prepared via electrohydrodynamic cojetting with side-by-side needle geometry. These nanofibers have a thermally responsive, physically-crosslinked compartment, and a chemically-crosslinked compartment at the nanoscale. The thermally responsive compartment is composed of physically crosslinkable poly(N-isopropylacrylamide poly(NIPAM copolymers, and poly(NIPAM-co-stearyl acrylate poly(NIPAM-co-SA, while the thermally-unresponsive compartment is composed of polyethylene glycol dimethacrylates. The two distinct compartments were physically crosslinked by the hydrophobic interaction of the stearyl chains of poly(NIPAM-co-SA or chemically stabilized via ultraviolet irradiation, and were swollen in physiologically relevant buffers due to their hydrophilic polymer networks. Bicompartmental nanofibers with the physically-crosslinked network of the poly(NIPAM-co-SA compartment showed a thermally-triggered shape change due to thermally-induced aggregation of poly(NIPAM-co-SA. Furthermore, when bovine serum albumin and dexamethasone phosphate were separately loaded into each compartment, the bicompartmental nanofibers with anisotropic actuation exhibited decoupled, controlled release profiles of both drugs in response to a temperature. A new class of multicompartmental nanofibers could be

  1. Distress risk and leverage puzzles: Evidence from Taiwan

    Directory of Open Access Journals (Sweden)

    Kung-Cheng Ho

    2016-05-01

    Full Text Available Financial distress has been invoked in the asset pricing literature to explain the anomalous patterns in the cross-section of stock returns. The risk of financial distress can be measured using indexes. George and Hwang (2010 suggest that leverage can explain the distress risk puzzle and that firms with high costs choose low leverage to reduce distress intensities and earn high returns. This study investigates whether this relationship exists in the Taiwan market. When examined separately, distress intensity is found to be negatively related to stock returns, but leverage is found to not be significantly related to stock returns. The results are the same when distress intensity and leverage are examined simultaneously. After assessing the robustness by using O-scores, distress risk puzzle is found to exist in the Taiwan market, but the leverage puzzle is not

  2. Origin of the violation of the Gottfried sum rule

    International Nuclear Information System (INIS)

    Hwang, W.P.; Speth, J.

    1992-01-01

    Using generalized Sullivan processes to generate sea-quark distributions of a nucleon at Q 2 =4 GeV 2 , we find that the recent finding by the New Muon Collaboration on the violation of the Gottfried sum rule can be understood quantitatively, including the shape of F 2 p (x)-F 2 n (x) as a function of x. The agreement may be seen as a clear evidence toward the validity of a recent suggestion of Hwang, Speth, and Brown that the sea distributions of a hadron, at low and moderate Q 2 (at least up to a few GeV 2 ), may be attributed primarily to generalized Sullivan processes

  3. Whistleblowing Environment in Indonesian Financial Institutions

    Directory of Open Access Journals (Sweden)

    Jennifer Erwin

    2015-12-01

    Full Text Available This study investigates the whistleblowing environment in Indonesian financial institutions from Indonesian employees’ perspective. Using primary data extracted from questionnaires this study to address two issues: investigate and explore the factor that encourages and discourages Indonesian employees to whistleblower in the Indonesian financial industry; and investigate and explore the Indonesian financial company’s environment that affects whistleblowing activity. Results were consistent with previous research by Martens and Kelleher (2004, Curtis (2006, Hwang, Staley, Chen and Lan (2008, Dandekar (1991 and Worth (2013 in their relative domains. The Indonesian employees and financial institutions are less influenced by confusion culture (guanxi which provides some variations in findings from prior research. Generally in Indonesia Financial Institutions there is a positive sign towards whistleblowing activity, “where” companies create a positive environment to support the activity although more could be done by government to regulate and enforce compliance to encourage trust in protecting employees when whistleblowing.

  4. Femtosecond laser ablation of silver foil with single and double pulses

    CSIR Research Space (South Africa)

    Roberts, DE

    2009-01-01

    Full Text Available . Tan, B.K.A. Ngoi, Opt. Laser Technol. 34 (2002) 199–202. [5] M. Hashida, A.F. Semerok, O. Gobert, G. Petite, Y. Izawa, J.F. Wagner, Appl. Surf. Sci. 197–198 (2002) 862–867. [6] P.T. Mannion, J. Magee, E. Coyne, G.M. O’Connor, Proc. SPIE 4876 (2003.... Nicolas, D. Anglos, Spectrochim. Acta B 63 (2008) 1006– 1010. [25] S. Singha, Z. Hu, R.J. Gordon, J. Appl. Phys. 104 (2008) 113520. [26] T.Y. Choi, D.J. Hwang, C.P. Girgoropoulos, Appl. Surf. Sci. (2002) 720–725. [27] A. Semerok, C. Dutouquet, Thin...

  5. Shor-Preskill-type security proof for quantum key distribution without public announcement of bases

    International Nuclear Information System (INIS)

    Hwang, Won-Young; Wang Xiangbin; Matsumoto, Keiji; Kim, Jaewan; Lee, Hai-Woong

    2003-01-01

    We give a Shor-Preskill-type security proof to quantum key distribution without public announcement of bases [W.Y. Hwang et al., Phys. Lett. A 244, 489 (1998)]. First, we modify the Lo-Chau protocol once more so that it finally reduces to the quantum key distribution without public announcement of bases. Then we show how we can estimate the error rate in the code bits based on that in the checked bits in the proposed protocol, which is the central point of the proof. We discuss the problem of imperfect sources and that of large deviation in the error rate distributions. We discuss when the bases sequence must be discarded

  6. Integrated model of Korean spent fuel and high level waste disposal options - 16091

    International Nuclear Information System (INIS)

    Hwang, Yongsoo; Miller, Ian

    2009-01-01

    This paper describes an integrated model developed by the Korean Atomic Energy Research Institute (KAERI) to simulate options for disposal of spent nuclear fuel (SNF) and reprocessing products in South Korea. A companion paper (Hwang and Miller, 2009) describes a systems-level model of Korean options for spent nuclear fuel (SNF) management in the 21. century. The model addresses alternative design concepts for disposal of SNF of different types (Candu, PWR), high level waste, and fission products arising from a variety of alternative fuel cycle back ends. It uses the GoldSim software to simulate the engineered system, near-field and far-field geosphere, and biosphere, resulting in long-term dose predictions for a variety of receptor groups. The model's results allow direct comparison of alternative repository design concepts, and identification of key parameter uncertainties and contributors to receptor doses. (authors)

  7. Development of the ENVI simulator to estimate Korean SNF flow and its cost - 16060

    International Nuclear Information System (INIS)

    Hwang, Yongsoo; Miller, Ian

    2009-01-01

    This paper describes an integrated model developed by the Korean Atomic Energy Research Institute (KAERI) to simulate options for managing spent nuclear fuel (SNF) in South Korea. A companion paper (Hwang and Miller, 2009) describes a performance assessment model to address the long-term safety of alternative geological disposal options for different waste streams. The model addresses alternative concepts for storage, transportation, and processing of SNF of different types (Candu, PWR), leading up to permanent disposal in geological repositories. It uses the GoldSim software to simulate the logistics of the associated activities, including the associated capital and operating costs. The model's results allow direct comparison of alternative waste management concepts, and predict the sizes and timings of different facilities required. Future versions of the model will also address the uncertainties associated with the different system components in order to provide risk-based assessments. (authors)

  8. Fatigue testing of wood composites for aerogenerator blades. Pt. 11: Assessment of fatigue damage accumulation using a fatigue modulus approach

    Energy Technology Data Exchange (ETDEWEB)

    Hacker, C L; Ansell, M P [Bath Univ. (United Kingdom)

    1996-12-31

    Stress-strain hysteresis loops have been captured during fatigue tests performed at R=10 (compression-compression) and R=0.1 (tension-tension) on Khaya epoxy wood composites. A fatigue modulus approach, proposed by Hwang and Han in 1989, has been applied to the data and a relationship established between the initial change in fatigue modulus and fatigue life. By following changes in fatigue modulus during the first 100 test cycles it is possible to predict the life of the sample allowing rapid evaluation of the fatigue performance of wood composites. Fatigue modulus values have also been calculated for hysteresis loops captured during complex load - time history tests. Similar trends in change in fatigue modulus suggest that this approach could be used in complex loading conditions to evaluate fatigue damage accumulation and predict fatigue life. (Author)

  9. Cryptanalysis on the improved multiparty quantum secret sharing protocol based on the GHZ state

    International Nuclear Information System (INIS)

    Chen Xiubo; Yang Shuai; Su Yuan; Yang Yixian

    2012-01-01

    Recently, Liu et al (2011 Phys. Scr. 84045015) pointed out that the multiparty quantum secret sharing (MQSS) protocol based on the GHZ state (Hwang et al 2011 Phys. Scr. 83045004) is insecure. They found that an inside participant can deduce half of the sender's secret information directly just by his piece of the secret. In order to resist this attack, an improvement was put forward. However, in this paper, we find that Liu et al's improved protocol is still insecure. We give details of three attack strategies to steal the secret information. It is shown that the eavesdropper can steal half or all of the secret information. Furthermore, a simple and ingenious MQSS protocol is proposed. We perform explicit cryptanalysis to prove that our improved protocol can resist the attacks from both the outside attackers and the inside participants, even the collusion attack.

  10. Foliation theory in algebraic geometry

    CERN Document Server

    McKernan, James; Pereira, Jorge

    2016-01-01

    Featuring a blend of original research papers and comprehensive surveys from an international team of leading researchers in the thriving fields of foliation theory, holomorphic foliations, and birational geometry, this book presents the proceedings of the conference "Foliation Theory in Algebraic Geometry," hosted by the Simons Foundation in New York City in September 2013.  Topics covered include: Fano and del Pezzo foliations; the cone theorem and rank one foliations; the structure of symmetric differentials on a smooth complex surface and a local structure theorem for closed symmetric differentials of rank two; an overview of lifting symmetric differentials from varieties with canonical singularities and the applications to the classification of AT bundles on singular varieties; an overview of the powerful theory of the variety of minimal rational tangents introduced by Hwang and Mok; recent examples of varieties which are hyperbolic and yet the Green-Griffiths locus is the whole of X; and a classificati...

  11. Writing about an experience of illness in medical students

    Directory of Open Access Journals (Sweden)

    Hwang K

    2013-08-01

    Full Text Available Kun Hwang,1 Huan Fan,1 Se Won Hwang2 1Department of Plastic Surgery, Inha University School of Medicine, Incheon, Korea; 2Peninsula Medical School, Exeter, UK Abstract: Pathography is defined as “historical biography from a medical, psychological, and psychiatric viewpoint.” We thought that writing about an experience of illness might help students understand patients’ experience and in turn grow in terms of self-understanding. Participants included 151 medical students. Students wrote about their own experience of illness and were asked to answer questions from the Likert scale. Most students wrote about themselves (79.2%; however, some students (20.8% wrote about the illness of others. Among the 149 pathographies, ecopathography was most frequent (30.9%, followed by testimonial pathography (25.5%; angry pathography (13.4% and alternative pathography (12.1% were relatively less frequent. Eighty-eight pathographies (59.1% showed 120 expressions of family relationship. Among the 120 cases, worrying about family members was most frequent (47.5%, followed by reliance on a family member (32.5%. All students wrote about the enlightenment experienced on returning to daily life. The sense of belonging together was most frequent (38.3%, followed by gratitude for living (20.8%, resolution to be a good doctor (18.1%, and a will to live and be healthy (12.1%. Answers on the Likert scale (total 5 for pathography beneficence were very high in understanding desirable doctor image (4.46, attaining morals and personality as a health care professional (4.49, and understanding basic communication skills (4.46. Writing about an experience of illness allows students to better understand patients’ experience and to grow in self-understanding. Keywords: writing, disease, patients, narration, pathography

  12. Electricity from bagasse in Zimbabwe

    International Nuclear Information System (INIS)

    Mbohwa, C.; Fukuda, S.

    2003-01-01

    Zimbabwe has suffered electrical power shortages resulting in electrical energy imports rising to between 40% and 50% of total energy needs. Electricity generation capacity has stagnated at around 2000 Megawatts (MW e ) since 1985, when two thermal units totaling 440 MW e were completed at Hwange. The effective capacity is 1.75 GW e . The current plan is to increase capacity by installing 600 MW e at Hwange at a cost of at least US $ 600 million. Raising this level of capital is difficult hence over the last 15 years there has been a failure to increase capacity. This article is based on a study of bagasse cogeneration in Zimbabwe and Mauritius conducted over a two-year period. It discusses technology improvements that can be made in the sugar sector to improve process and energy efficiency for the purposes of becoming an independent power producer that supplies power to the grid continuously throughout the year. Power plant investment in the sugar industry offers a bridging and realizable alternative for electricity generation in Zimbabwe. Investment in a 35 MW e bagasse (moisturized fiber left when sugar has been extracted from sugarcane) system would require a capital of about US$ 35 million using modern technology based on experiences in Mauritius and Reunion. A technical and economic evaluation and analysis reveals that bagasse power development is technically and economically feasible if electricity is priced at the long-term marginal cost. At current import prices, financial assistance from the global environment facility and/or the clean development mechanism of the Kyoto protocol would be necessary. The solving of the current political and economic problems in the country would pave the way for attracting a technical partner and development, of bagasse power using domestic and international financing

  13. The tree-species-specific effect of forest bathing on perceived anxiety alleviation of young-adults in urban forests

    Directory of Open Access Journals (Sweden)

    Haoming Guan

    2017-12-01

    Full Text Available Forest bathing, i.e. spending time in a forest to walk, view and breathe in a forest, can alleviate the mental depression of visitors, but the tree-species-specific effect of this function by the urban forest is unknown. In this study, sixty-nine university students (aged 19-22, male ratio: 38% were recruited as participants to visit urban forests dominated by birch (Betula platyphylla Suk., maple (Acer triflorum Komarov and oak (Quercus mongolica Fisch. ex Ledeb trees in a park at the center of Changchun City, Northeast China. In the maple forest only the anxiety from study interest was decreased, while the anxiety from employment pressure was alleviated to the most extent in the birch forest. Participants perceived more anxiety from lesson declined in the oak forest than in the birch forest. Body parameters of weight and age were correlated with the anti-anxiety scores. In the oak forest, female participants can perceive more anxiety alleviation than male participants. For university students, forest bathing in our study can promote their study interest. Forest bathing can be more effective to alleviate the anxiety of young adults with greater weight. The birch forest was recommended to be visited by students to alleviate the pressure of employment worry, and the oak forest was recommended to be visited by girls.

  14. Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors

    Directory of Open Access Journals (Sweden)

    Chur Chin

    2010-04-01

    Full Text Available Chur Chin1, In Kyeom Kim2, Dong Yoon Lim3, Ki Suk Kim4, Hyang Ae Lee4, Eun Joo Kim41Department of Pediatrics, Fatima Hospital, Daegu, Korea; 2Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Korea; 3Department of Pharmacology, School of Medicine, Chosun University, Gwangju, Korea; 4Korea Institute of Toxicology, Daejeon, KoreaAbstract: We identified a novel class of direct ion-channel blockers of ligand-gated ion channels called the gold nanoparticle–choline complex. Negatively charged gold nanoparticles (1.4 nm block ion pores by binding to the sulfur group of the cysteine loop of nicotinic acetylcholine receptors (nAChRs, and currents evoked by acetylcholine (Ach can break these bonds. The current evoked by ACh in nAChRs was blocked directly in ion pores by the gold nanoparticle–choline complex. In adrenal-gland perfusion studies, the complex also blocked nAChRs by diminishing catecholamine release by about 75%. An in vivo study showed muscle relaxation in rats after injection of the complex. These results will foster the application of gold nanoparticles as a direct ion-channel blocker. Keywords: negatively charged gold nanoparticle, choline, gold–sulfur bond, nicotinic acetylcholine receptor, direct ion-channel blocker

  15. [Clinical application of stand-alone MC+PEEK cage in the anterior cervical fusion].

    Science.gov (United States)

    Jiang, Bing; Cao, Yan-Qing; Pan, Hong; Zhu, Cheng-Run; Zhang, Xiao-Jun; Tao, Yue-Feng; Liu, Zhen

    2015-04-01

    To explore the effect of clinical application of stand-alone MC+PEEK cage in anterior cervical fusion. From January 2011 to January 2014,50 patients were treated with the MC+PEEK cage filled with autogenous cancellous illic-bone graft after anterior cervical discectomy. There were 22 patients with cervical spondylosis,26 patients with traumatic cervical disc herniation, 2 patients with cervical instability in these patients. There were 32 males and 18 females, aged from 30 to 79 years old with an average of 53.30 years old. There were 32 patients with single segment, 15 patients with double segments and 3 patients with three segments. Cervical AP and lateral and the flexion-extension X-rays were regularly taken in order to assess the cervical physiological curvature, the graft fusion and internal fixation related complications. Nerve function, clinical effect and bone fusion were respectively evaluated according to Japan Orthopedic Association (JOA), Otani grade and Suk method. All patients were followed up from 6 to 36 months with an average of 20 months. No correlated surgical complications were found and all patients obtained bony fusion with an average time of 4.30 months. JOA score had significantly improvement after surgery (P cervical fusion can obtain satisfactory clinical effect with less operation injury and reduce the complications. It is a better fusion method in anterior cervical fusion.

  16. Low-cost flexible supercapacitors with high-energy density based on nanostructured MnO2 and Fe2O3 thin films directly fabricated onto stainless steel

    Science.gov (United States)

    Gund, Girish S.; Dubal, Deepak P.; Chodankar, Nilesh R.; Cho, Jun Y.; Gomez-Romero, Pedro; Park, Chan; Lokhande, Chandrakant D.

    2015-07-01

    The facile and economical electrochemical and successive ionic layer adsorption and reaction (SILAR) methods have been employed in order to prepare manganese oxide (MnO2) and iron oxide (Fe2O3) thin films, respectively with the fine optimized nanostructures on highly flexible stainless steel sheet. The symmetric and asymmetric flexible-solid-state supercapacitors (FSS-SCs) of nanostructured (nanosheets for MnO2 and nanoparticles for Fe2O3) electrodes with Na2SO4/Carboxymethyl cellulose (CMC) gel as a separator and electrolyte were assembled. MnO2 as positive and negative electrodes were used to fabricate symmetric SC, while the asymmetric SC was assembled by employing MnO2 as positive and Fe2O3 as negative electrode. Furthermore, the electrochemical features of symmetric and asymmetric SCs are systematically investigated. The results verify that the fabricated symmetric and asymmetric FSS-SCs present excellent reversibility (within the voltage window of 0-1 V and 0-2 V, respectively) and good cycling stability (83 and 91%, respectively for 3000 of CV cycles). Additionally, the asymmetric SC shows maximum specific capacitance of 92 Fg-1, about 2-fold of higher energy density (41.8 Wh kg-1) than symmetric SC and excellent mechanical flexibility. Furthermore, the “real-life” demonstration of fabricated SCs to the panel of SUK confirms that asymmetric SC has 2-fold higher energy density compare to symmetric SC.

  17. Low-cost flexible supercapacitors with high-energy density based on nanostructured MnO2 and Fe2O3 thin films directly fabricated onto stainless steel

    Science.gov (United States)

    Gund, Girish S.; Dubal, Deepak P.; Chodankar, Nilesh R.; Cho, Jun Y.; Gomez-Romero, Pedro; Park, Chan; Lokhande, Chandrakant D.

    2015-01-01

    The facile and economical electrochemical and successive ionic layer adsorption and reaction (SILAR) methods have been employed in order to prepare manganese oxide (MnO2) and iron oxide (Fe2O3) thin films, respectively with the fine optimized nanostructures on highly flexible stainless steel sheet. The symmetric and asymmetric flexible-solid-state supercapacitors (FSS-SCs) of nanostructured (nanosheets for MnO2 and nanoparticles for Fe2O3) electrodes with Na2SO4/Carboxymethyl cellulose (CMC) gel as a separator and electrolyte were assembled. MnO2 as positive and negative electrodes were used to fabricate symmetric SC, while the asymmetric SC was assembled by employing MnO2 as positive and Fe2O3 as negative electrode. Furthermore, the electrochemical features of symmetric and asymmetric SCs are systematically investigated. The results verify that the fabricated symmetric and asymmetric FSS-SCs present excellent reversibility (within the voltage window of 0–1 V and 0–2 V, respectively) and good cycling stability (83 and 91%, respectively for 3000 of CV cycles). Additionally, the asymmetric SC shows maximum specific capacitance of 92 Fg−1, about 2-fold of higher energy density (41.8 Wh kg−1) than symmetric SC and excellent mechanical flexibility. Furthermore, the “real-life” demonstration of fabricated SCs to the panel of SUK confirms that asymmetric SC has 2-fold higher energy density compare to symmetric SC. PMID:26208144

  18. Topics in 2 + 1 and 3 + 1 dimensional physics

    International Nuclear Information System (INIS)

    Camperi, M.F.

    1994-01-01

    This thesis is concerned with the study of two different topics pertaining to two different dimensionalities in Field Theory. First, the issues Chern-Simons Gauge Field Theory in 2 + 1 dimensions, mainly as a field theoretic description of knots and links in three euclidean dimensions is addressed. The author provides both a non-perturbative and a perturbative approach, relating them in the large-N limit. A non-perturbative duality was found between the SU(N) k Chern-Simons theory and the SU(k) N one, providing a possible physical consequences of these constructions, notably the case of Fractional Statistics. Second, this thesis addresses the study of the so-called open-quotes vector modelclose quotes, written in the language of Chiral Perturbation Theory in the physical (3 + 1)-dimensional space time. This model was introduced as a possible way to study the physics of vector and pseudoscalar mesons and is based on the assumption that there is a limit of QCD where the vector mesons become massless. The author relates this model to the Hidden Symmetry Scheme, a model sharing the motivation with the previous one, but based on different assumptions. Considering only well established physical results as vector meson dominance, The thesis concludes that the vector model does not appear to be a good candidate for the effective description of vector mesons

  19. Entangled spin chain

    Science.gov (United States)

    Salberger, Olof; Korepin, Vladimir

    We introduce a new model of interacting spin 1/2. It describes interactions of three nearest neighbors. The Hamiltonian can be expressed in terms of Fredkin gates. The Fredkin gate (also known as the controlled swap gate) is a computational circuit suitable for reversible computing. Our construction generalizes the model presented by Peter Shor and Ramis Movassagh to half-integer spins. Our model can be solved by means of Catalan combinatorics in the form of random walks on the upper half plane of a square lattice (Dyck walks). Each Dyck path can be mapped on a wave function of spins. The ground state is an equally weighted superposition of Dyck walks (instead of Motzkin walks). We can also express it as a matrix product state. We further construct a model of interacting spins 3/2 and greater half-integer spins. The models with higher spins require coloring of Dyck walks. We construct a SU(k) symmetric model (where k is the number of colors). The leading term of the entanglement entropy is then proportional to the square root of the length of the lattice (like in the Shor-Movassagh model). The gap closes as a high power of the length of the lattice [5, 11].

  20. Microfacies and Diagenetic Fabric of the Lockhart Limestone, Kotal Pass Section, Northeast of Kohat, Pakistan

    Directory of Open Access Journals (Sweden)

    Muhammad Waseem Khan

    2016-06-01

    Full Text Available The present study is intended to describe the carbonate microfacies of the Paleocene Lockhart Limestone in area northeast of the Kohat City. The analyzed limestone in the area is 65m thick and predominantly medium to thick bedded, nodular to brecciated and richly fossiliferous. Thin interbeds of marl are observed in the main lithological unit. The lower contact of the Lockhart Limestone is faulted with the Samana Suk Formation of the Jurassic age while conformably overlain by the Patala Formation of Paleocene to Eocene age. The major lithological unit is comprised of predominant assemblage of larger benthic and smaller planktonic foraminifers with accretion of ostracods, dasycladacean algae, echinoderms, gastropods and corals. On the basis of field and laboratory observations, two distinct types of microfacies have been identified as i Dasyclad-Miliolid Foram Wacke-Packstone microfacies of the inner shelf, sub tidal lagoon, ii Larger Foram Packstone microfacies of the middle shelf. The Limestone represents a carbonate cyclic sequence marked by three, transgressive, deepening up cycles representing a gradual sea level rise compensated by vertical accumulation of microfacies. The commencement of each cycle is clearly marked by the input of land-derived siliciclastic sediments and near shore restricted marine faunal/floral assemblage in the inner shelf microfacies gradually thinning up section where the microfacies become deeper offshore. The diagenetic modifications are observed in the shape of compactional framework, dolomitization, aragonite to calcite alteration and spar filled fractures in the main lithological unit of the Lockhart Limestone.

  1. Robots could assist scientists working in Greenland

    Science.gov (United States)

    Showstack, Randy

    2011-07-01

    GREENLAND—Tom Lane and Suk Joon Lee, recent graduates of Dartmouth University's Thayer School of Engineering, in Hanover, N. H., are standing outside in the frigid cold testing an autonomous robot that could help with scientific research and logistics in harsh polar environments. This summer, Lane, Lee, and others are at Summit Station, a U.S. National Science Foundation (NSF)-sponsored scientific research station in Greenland, fine-tuning a battery-powered Yeti robot as part of a team working on the NSF-funded Cool Robot project. The station, also known as Summit Camp, is located on the highest point of the Greenland Ice Sheet (72°N, 38°W, 3200 meters above sea level) near the middle of the island. It is a proving ground this season for putting the approximately 68-kilogram, 1-cubic-meter robot through its paces, including improving Yeti's mobility capabilities and field-testing the robot. (See the electronic supplement to this Eos issue for a video of Yeti in action (http://www.agu.org/eos_elec/).) During field-testing, plans call for the robot to collect data on elevation and snow surface characteristics, including accumulation. In addition, the robot will collect black carbon and elemental carbon particulate matter air samples around Summit Camp's power generator to help study carbon dispersion over snow.

  2. Heterotrimeric Kinesin II Is the Microtubule Motor Protein Responsible for Pigment Dispersion in Xenopus Melanophores

    Science.gov (United States)

    Tuma, M. Carolina; Zill, Andrew; Le Bot, Nathalie; Vernos, Isabelle; Gelfand, Vladimir

    1998-01-01

    Melanophores move pigment organelles (melanosomes) from the cell center to the periphery and vice-versa. These bidirectional movements require cytoplasmic microtubules and microfilaments and depend on the function of microtubule motors and a myosin. Earlier we found that melanosomes purified from Xenopus melanophores contain the plus end microtubule motor kinesin II, indicating that it may be involved in dispersion (Rogers, S.L., I.S. Tint, P.C. Fanapour, and V.I. Gelfand. 1997. Proc. Natl. Acad. Sci. USA. 94: 3720–3725). Here, we generated a dominant-negative construct encoding green fluorescent protein fused to the stalk-tail region of Xenopus kinesin-like protein 3 (Xklp3), the 95-kD motor subunit of Xenopus kinesin II, and introduced it into melanophores. Overexpression of the fusion protein inhibited pigment dispersion but had no effect on aggregation. To control for the specificity of this effect, we studied the kinesin-dependent movement of lysosomes. Neither dispersion of lysosomes in acidic conditions nor their clustering under alkaline conditions was affected by the mutant Xklp3. Furthermore, microinjection of melanophores with SUK4, a function-blocking kinesin antibody, inhibited dispersion of lysosomes but had no effect on melanosome transport. We conclude that melanosome dispersion is powered by kinesin II and not by conventional kinesin. This paper demonstrates that kinesin II moves membrane-bound organelles. PMID:9852150

  3. Whiteness and the Blackening of Italy: La guerra cafona, Extracommunitari and Provisional Street Justice

    Directory of Open Access Journals (Sweden)

    Joseph Pugliese

    2008-12-01

    Full Text Available In this essay, I briefly revisit the historical moment of Italian unification, drawing attention to its violent colonial dimensions and the twenty years of insurgent southern brigandage that erupted immediately after unification, in order to begin to trace the survival of this southern insurrectionary and anti-nationalist movement in the contemporary Italian context. In the process of focusing on the manner in which a statue of the Italian national poet, Dante, has been graffitied by southern youth in a square in Naples, I transpose the historical tradition of southern brigandage, returning the term back to its insurgent political roots, in order to begin to establish lines of connection between seemingly disparate politico-cultural practices and genealogies; in particular, I examine contemporary southern hip hop culture, including graffiti and rap, in relation to the history of southern anti-unification and counter-nationalist movements, marking the transmediterranean-atlantic politico-cultural flows that inscribe southern hip hop culture. I conclude by bringing into contemporary focus this northern history of anti-southern discrimination and exploitation by drawing attention to the plight of recent immigrants from the Global South that constitute the underbelly of contemporary Italy’s economic prosperity. My focus here is on mapping points of polico-cultural connection between immigrants of the Global South and meridionali through the instantiation of such tactical cultural practices as establishing suks and transitory markets in Italy’s civic squares.

  4. Effect of hydroxyapatite-containing microspheres embedded into three-dimensional magnesium phosphate scaffolds on the controlled release of lysozyme and in vitro biodegradation

    Directory of Open Access Journals (Sweden)

    Lee JM

    2014-09-01

    Full Text Available Jongman Lee, Hui-suk YunPowder and Ceramics Division, Korea Institute of Materials Science, Changwon, Republic of KoreaAbstract: The functionality of porous three-dimensional (3D magnesium phosphate (MgP scaffold was investigated for the development of a novel protein delivery system and biomimetic bone tissue engineering scaffold. This enhancement can be achieved by incorporation of hydroxyapatite (HA-containing polymeric microspheres (MSs into a bulk MgP matrix, and a paste-extruding deposition (PED system. In this work, the amount of MS and HA was precisely controlled when manufacturing MS-embedded MgP (MS/MgP composite scaffolds. The main influence was researched in terms of in vitro lysozyme-release, in vitro biodegradation, mechanical properties, and in vitro calcification. The controlled release of lysozyme was indicated, while showing graded release patterns according to HA content. The composite scaffolds degraded gradually with MS content and degradation time. Due to the effect of HA inclusion, the higher HA-containing MS/MgP scaffolds could, not only delay the biodegradation process but also, compensate for the possible loss of mechanical properties. In this regard, it is reasonable to confirm the inverse relationship between biodegradation and corresponding compressive properties. In order to encourage bioactivity and osteoconductivity, the MS/MgP composite scaffolds were subjected to simulated body fluid treatment. Calcium deposition was, in turn, improved with increasing MS and HA content over time. This quantitative result was also proved using morphological and elemental analysis. In summary, a significant transformation of a monolithic MgP scaffold was directed toward a multifunctional bone tissue engineering scaffold equipped with controlled protein delivery, biodegradability, and bioactivity.Keywords: protein delivery, bone tissue engineering

  5. The effect of neutral-surface iron oxide nanoparticles on cellular uptake and signaling pathways

    Directory of Open Access Journals (Sweden)

    Kim E

    2016-09-01

    Full Text Available Eunjoo Kim,1 Joon Mee Kim,2 Lucia Kim,2 Suk Jin Choi,2 In Suh Park,2 Jee Young Han,2 Young Chae Chu,2 Eun Sook Choi,1 Kun Na,3 Soon-Sun Hong4 1Division of Nano and Energy Convergence Research, Daegu Gyeongbuk Institute of Science and Technology (DGIST, Daegu, 2Department of Pathology, Inha University College of Medicine, Incheon, 3Department of Biotechnology, Catholic University of Korea, Bucheon, 4Department of Biomedical Sciences, Inha University College of Medicine, Incheon, South Korea Abstract: In recent years, iron oxide nanoparticles (IONPs have been applied widely to biomedical fields. However, the relationship between the physicochemical properties of IONPs and their biological behavior is not fully understood yet. We prepared 3-methacryloxypropyl­trimethoxysilane (MPS-coated IONPs, which have a neutral hydrophobic surface, and compared their biological behavior to that of Resovist (ferucarbotran, a commercialized IONP formulation modified with carboxymethyl dextran. The rate of MPS-IONP uptake by human aortic endothelial cells (HAoECs was higher than ferucarbotran uptake, indicating that the neutral hydrophobic nature of MPS-IONPs allowed them to be absorbed more readily through the plasma membrane. However, the signaling pathways activated by MPS-IONPs and ferucarbotran were comparable, suggesting that surface charge is not a key factor for inducing changes in HAoECs. In vivo fate analysis showed that MPS-IONPs accumulated for longer periods in tissues than hydrophilic ferucarbotran. These findings could enlarge our understanding of NP behavior for advanced applications in the biomedical field. Keywords: iron oxide nanoparticles, neutral hydrophobic surface, signaling pathway, uptake, accumulation, reactive oxygen species (ROS

  6. Nitrogen requirements of cassava in selected soils of Thailand

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    Jakchaiwat Kaweewong

    2013-08-01

    Full Text Available Cassava (Manihot esculenta is one of the most important export crops in Thailand, yet the nitrogen requirement is unknown and not considered by growers and producers. Cassava requirements for N were determined in field experiments during a period of four years and four sites on the Satuk (Suk, Don Chedi (Dc, Pak Chong (Pc,and Ban Beung (BBg soil series in Lopburi, Supanburi, Nakhon Ratchasima, and Chonburi sites, respectively. The fertilizer treatment structure comprised 0, 62.5, 125, 187.5, 250 and 312.5 kg N ha^(-1 as urea. At each site cassava was harvested at nine months and yield parameters and the minimum datasets were taken. The fertilizer rate which resulted in maximum yield ranged from 187.5 kg N ha^(-1 in Supanburi and Chonburi (fresh weight yield of 47,500 and 30,000 kg ha^(-1 respectively to 250 kg N ha^(-1 in Lopburi and Nakhon Ratchasima (fresh weight yield of 64,100 and 46,700 kg ha^(-1 respectively. Yield appeared to decrease at the higher, 312 kg ha^(-1, at Supanburi and Lopburi, and 250 kg ha^(-1 (Chonburi fertilizer N rates. Net revenue was 70.4 and 72.9 % higher than where no N was appliedLopburi and Nakhon Ratchasima sites. Net revenue at the Supanburi and Chonburi sites were 53.8 and 211.0 % higher than that where no N was applied. This study suggests that at all sites improved cassava production and net revenue could be obtained with the judicious application of higher quantities of N. The results provide needed guidance to nitrogen fertilization of the important industrial crop cassava in Thailand.

  7. Measuring negative symptoms in patients with schizophrenia: reliability and validity of the Korean version of the Motivation and Pleasure Scale-Self-Report

    Directory of Open Access Journals (Sweden)

    Kim JS

    2016-05-01

    Full Text Available Ji-Sun Kim,1 Seon-Kyeong Jang,1 Seon-Cheol Park,2 Jung-Seo Yi,3 Joong-Kyu Park,4 Jung Suk Lee,5 Kee-Hong Choi,6 Seung-Hwan Lee1,7 1Clinical Emotion and Cognition Research Laboratory, Goyang, 2Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, 3Department of Psychiatry, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, 4Department of Rehabilitation Psychology, Daegu University, Daegu, 5Department of Psychiatry, National Health Insurance Service Ilsan Hospital, Goyang, 6Department of Psychology, Korea University, Seoul, 7Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea Background: The Clinical Assessment Interview for Negative Symptoms (CAINS is one of the validated interview measures of negative symptoms in psychotic disorders. The Motivation and Pleasure Scale-Self-Report (MPSR is a self-report measure that assesses the motivation and pleasure domains of negative symptoms based on the CAINS. This study evaluated the reliability and validity of a Korean version of the MPSR.Methods: A total of 139 patients with schizophrenia completed the MPSR, CAINS, Scale for the Assessment of Negative Symptoms (SANS, Brief Psychiatric Rating Scales, Calgary Depression Scale for Schizophrenia, and other measures of trait and cognitive function.Results: The 15-item MPSR showed good internal consistency. In addition, it also had a good convergent validity with the Motivation and Pleasure subscale of the CAINS and the anhedonia/avolition subscale of the SANS. The scale was not associated with psychotic symptoms, agitation/mania, and depression/anxiety, and it showed good discriminant validity. MPSR scores were significantly correlated with Behavioral Activation System total score for trait measure.Conclusion: The Korean version of the MPSR is a notable self-report method for examining the severity of negative symptoms in schizophrenia. Keywords: Korean

  8. IAEA Technical Co-operation activities: Asia and the Pacific. Workshop on training nuclear laboratory technicians

    International Nuclear Information System (INIS)

    Roeed, S.S.

    1976-01-01

    The workshop was held to exchange information on existing facilities and programmes in Asia and the Pacific for training nuclear laboratory technicians, to identify future training needs and to assess the need for IAEA's involvement in this field. As the participants outlined the requirements for nuclear laboratory technician training and the facilities available in their respective countries, it became evident that, in addition to the training of radioisotope laboratory technicians, they also wished to review the need for technician training for the operation of nuclear power plants and industrial application of atomic energy. The terms of reference of the workshop were extended accordingly. The opening address by Chang Suk Lee, the Korean Vice Minister of Science and Technology, noted the valuable contribution to quality control and other industrial uses that nuclear techniques have made in his country. He also reviewed the application of nuclear techniques in Korean agriculture and medicine. The participants explored various forms of co-operation that could be established between countries of the region. Exchange programmes, not only for students but also for expert teachers, and the exchange or loan of equipment were suggested. It was felt that some generalized training courses could be organized on a regional basis, and two countries advocated the setting up of a regional training centre. One suggestion was to arrange regional training courses in special fields that would move from one country to another. The need was felt for periodic regional meetings on training methods, course content and other questions relating to training of laboratory technicians. The IAEA was requested to act as a clearinghouse for information on available training facilities in the region and to advise on the curricula for technician training courses. The Agency was also asked to organize short courses for the training of instructors of technicians in the various fields of atomic

  9. Early results of pediatric appendicitis after adoption of diagnosis-related group-based payment system in South Korea

    Directory of Open Access Journals (Sweden)

    Moon SB

    2015-11-01

    Full Text Available Suk-Bae MoonDepartment of Surgery, Kangwon National University Hospital, Kangwon National School of Medicine, Kangwon National University, Chuncheon, South KoreaPurpose: As an alternative to the existing fee-for-service (FFS system, a diagnosis-related group (DRG-based payment system has been suggested. The aim of this study was to investigate the early results of pediatric appendicitis treatment under the DRG system, focusing on health care expenditure and quality of health care services.Patients and methods: The medical records of 60 patients, 30 patients before (FFS group, and 30 patients after adoption of the DRG system (DRG, were reviewed retrospectively.Results: Mean hospital stay was shortened, but the complication and readmission rates did not worsen in the DRG. Overall health care expenditure and self-payment decreased from Korean Won (KRW 2,499,935 and KRW 985,540, respectively, in the FFS group to KRW 2,386,552 and KRW 492,920, respectively, in the DRG. The insurer’s payment increased from KRW 1,514,395 in the FFS group to KRW 1,893,632 in the DRG. For patients in the DRG, calculation by the DRG system yielded greater overall expenditure (KRW 2,020,209 vs KRW 2,386,552 but lower self-payment (KRW 577,803 vs KRW 492,920 than calculation by the FFS system.Conclusion: The DRG system worked well in pediatric patients with acute appendicitis in terms of cost-effectiveness over the short term. The gradual burden on the national health insurance fund should be taken into consideration.Keywords: appendicitis, child, fee-for-service plans, diagnosis-related groups, quality of health care, health care expenditures

  10. [The early medical textbooks in Korea: medical textbooks published at Je Joong Won-Severance Hospital Medical School].

    Science.gov (United States)

    Park, H W

    1998-01-01

    Kwang Hye Won(Je Joong Won), the first western hospital in Korea, was founded in 1885. The first western Medical School in Korea was open in 1886 under the hospital management. Dr. O. R. Avison, who came to Korea in 1893, resumed the medical education there, which was interrupted for some time before his arrival in Korea. He inaugurated translating and publishing medical textbooks with the help of Kim Pil Soon who later became one of the first seven graduates in Severance Hospital Medical School. The first western medical textbook translated into Korean was Henry Gray's Anatomy. However, these twice-translated manuscripts were never to be published on account of being lost and burnt down. The existing early anatomy textbooks, the editions of 1906 and 1909, are not the translation of Gray's Anatomy, but that of Japanese anatomy textbook of Gonda. The remaining oldest medical textbook in Korean is Inorganic Materia Medica published in 1905. This book is unique among its kind that O. R. Avison is the only translator of the book and it contains the prefaces of O. R. Avison and Kim Pil Soon. The publication of medical textbook was animated by the participation of other medical students, such as Hong Suk Hoo and Hong Jong Eun. The list of medical textbooks published includes almost all the field of medicine. The medical textbooks in actual existence are as follows: Inorganic Materia Medica (1905), Inorganic Chemistry (1906), Anatomy I (1906), Physiology (1906), Diagnostics I (1906), Diagnostics II (1907), Obstetrics (1908), Organic Chemistry (1909), Anatomy (1909), and Surgery (1910).

  11. Use of Machine Learning Classifiers and Sensor Data to Detect Neurological Deficit in Stroke Patients.

    Science.gov (United States)

    Park, Eunjeong; Chang, Hyuk-Jae; Nam, Hyo Suk

    2017-04-18

    The pronator drift test (PDT), a neurological examination, is widely used in clinics to measure motor weakness of stroke patients. The aim of this study was to develop a PDT tool with machine learning classifiers to detect stroke symptoms based on quantification of proximal arm weakness using inertial sensors and signal processing. We extracted features of drift and pronation from accelerometer signals of wearable devices on the inner wrists of 16 stroke patients and 10 healthy controls. Signal processing and feature selection approach were applied to discriminate PDT features used to classify stroke patients. A series of machine learning techniques, namely support vector machine (SVM), radial basis function network (RBFN), and random forest (RF), were implemented to discriminate stroke patients from controls with leave-one-out cross-validation. Signal processing by the PDT tool extracted a total of 12 PDT features from sensors. Feature selection abstracted the major attributes from the 12 PDT features to elucidate the dominant characteristics of proximal weakness of stroke patients using machine learning classification. Our proposed PDT classifiers had an area under the receiver operating characteristic curve (AUC) of .806 (SVM), .769 (RBFN), and .900 (RF) without feature selection, and feature selection improves the AUCs to .913 (SVM), .956 (RBFN), and .975 (RF), representing an average performance enhancement of 15.3%. Sensors and machine learning methods can reliably detect stroke signs and quantify proximal arm weakness. Our proposed solution will facilitate pervasive monitoring of stroke patients. ©Eunjeong Park, Hyuk-Jae Chang, Hyo Suk Nam. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 18.04.2017.

  12. Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration

    Directory of Open Access Journals (Sweden)

    La WG

    2014-05-01

    Full Text Available Wan-Geun La,1 Min Jin,1 Saibom Park,1,2 Hee-Hun Yoon,1 Gun-Jae Jeong,1 Suk Ho Bhang,1 Hoyoung Park,1,2 Kookheon Char,1,2 Byung-Soo Kim1,31School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea; 2The National Creative Research Initiative Center for Intelligent Hybrids, Seoul National University, Seoul, Republic of Korea; 3Institute of Bioengineering, Institute of Chemical Processes, Engineering Research Institute, Seoul National University, Seoul, Republic of KoreaAbstract: In this study, we demonstrate that graphene oxide (GO can be used for the delivery of bone morphogenetic protein-2 (BMP-2 and substance P (SP, and that this delivery promotes bone formation on titanium (Ti implants that are coated with GO. GO coating on Ti substrate enabled a sustained release of BMP-2. BMP-2 delivery using GO-coated Ti exhibited a higher alkaline phosphatase activity in bone-forming cells in vitro compared with bare Ti. SP, which is known to recruit mesenchymal stem cells (MSCs, was co-delivered using Ti or GO-coated Ti to further promote bone formation. SP induced the migration of MSCs in vitro. The dual delivery of BMP-2 and SP using GO-coated Ti showed the greatest new bone formation on Ti implanted in the mouse calvaria compared with other groups. This approach may be useful to improve osteointegration of Ti in dental or orthopedic implants.Keywords: bone morphogenetic protein-2, bone regeneration, graphene oxides, stem cell recruitment, substance P

  13. Propriedades termofísicas de soluções modelo similares a sucos - Parte I Thermophysical properties of model solutions similar to juice - Part I

    Directory of Open Access Journals (Sweden)

    Silvia Cristina Sobottka Rolim de Moura

    2003-04-01

    Full Text Available Propriedades termofísicas, difusividade térmica e calor específico, de soluções modelo similares a sucos, foram determinadas experimentalmente e ajustadas a modelos matemáticos (STATISTICA 6.0, em função da sua composição química. Para definição das soluções modelo foi realizado um planejamento estrela mantendo-se fixa a quantidade de ácido (1,5% e variando-se a água (82-98,5%, o carboidrato (0-15% e a gordura (0-1,5%. A determinação do calor específico foi realizada através do método de Hwang & Hayakawa e a difusividade térmica com base no método de Dickerson. Os resultados de cada propriedade foram analisados através de superfícies de respostas. Foram encontrados resultados significativos para as propriedades, mostrando que os modelos encontrados representam significativamente as mudanças das propriedades térmicas dos sucos, com alterações na composição e na temperatura.Thermophysical properties, thermal diffusivity and specific heat of model solutions similar to juices were experimentally determined and the values obtained compared to those predicted by mathematical models (STATISTIC 6.0 and to values mentioned in the literature, according to the chemical composition. It was adopted a star planning to define the composition of the model solutions fixing the acid amount in 1.5% and varying water (82-98.5%, carboydrate (0-15% and fat (0-1.5%. The specific heat was determined by Hwang & Hayakawa method and the thermal diffusivity was determined by Dickerson method. The results of each property were analysed by the response surface method. The results were significative, indicating that the models represented considerably the changes of thermal properties of juices according to their composition and temperature variations.

  14. Incorporation of international virtual teams as a complementary component to the traditional educational model Incorporación de virtual teams internacionales como componente complementario al modelo educativo tradicional

    Directory of Open Access Journals (Sweden)

    Carlos Fernando Arbeláez

    2012-08-01

    Full Text Available The model of virtual teams in higher education is being increasingly recognized as a phenomenon of great value to students about learning environments in the real world (Hsieh, Jang, Hwang, & Chen, 2011. Meanwhile, today’s environment requires from educational institutions dedicated to instruction undergraduate and graduate students, a rapid evolution of their models of teaching in order to conform to the same speed with which all fields transform in knowledge. This paper discusses the inclusion of virtual teams in the top-level educational models, meaning that incorporation as an option applies to all educational institutions, and above all, to their learning traditional structures. In this sense, the document includes analysis of relevant academic literature and data collected through interviews, conducted at six higher education faculty, who work in virtual teams schemes globally.El modelo de virtual teams en la educación superior está siendo reconocido cada vez máscomo un fenómeno de gran valor que acerca a los estudiantes a ambientes de aprendizajeen el mundo real (Hsieh, Jang, Hwang, & Chen, 2011. Por su parte, el entorno de hoyexige a las instituciones educativas dedicadas a la formación profesional en pregrado y posgrado, una rápida evolución de sus modelos de enseñanza a fin de ajustarlos a la mismavelocidad con la que se transforman todos los campos relacionados con el conocimiento.Este documento analiza la inclusión de virtual teams en los modelos educativos denivel superior, entendiendo dicha incorporación como una opción aplicable a todas lasinstituciones educativas, y sobre todo, a sus estructuras tradicionales de aprendizaje.En ese sentido, el documento incluye análisis de publicaciones académicas relevantes ydatos recopilados a través de entrevistas en profundidad, realizadas a seis profesores deeducación superior, quienes trabajan en esquemas de virtual teams a nivel global.

  15. Day-to-Day Dynamics of Commensal Escherichia coli in Zimbabwean Cows Evidence Temporal Fluctuations within a Host-Specific Population Structure.

    Science.gov (United States)

    Massot, Méril; Couffignal, Camille; Clermont, Olivier; D'Humières, Camille; Chatel, Jérémie; Plault, Nicolas; Andremont, Antoine; Caron, Alexandre; Mentré, France; Denamur, Erick

    2017-07-01

    To get insights into the temporal pattern of commensal Escherichia coli populations, we sampled the feces of four healthy cows from the same herd in the Hwange District of Zimbabwe daily over 25 days. The cows had not received antibiotic treatment during the previous 3 months. We performed viable E. coli counts and characterized the 326 isolates originating from the 98 stool samples at a clonal level, screened them for stx and eae genes, and tested them for their antibiotic susceptibilities. We observed that E. coli counts and dominant clones were different among cows, and very few clones were shared. No clone was shared by three or four cows. Clone richness and evenness were not different between cows. Within each host, the variability in the E. coli count was evidenced between days, and no clone was found to be dominant during the entire sampling period, suggesting the existence of clonal interference. Dominant clones tended to persist longer than subdominant ones and were mainly from phylogenetic groups A and B1. Five E. coli clones were found to contain both the stx 1 and stx 2 genes, representing 6.3% of the studied isolates. All cows harbored at least one Shiga toxin-producing E. coli (STEC) strain. Resistance to tetracycline, penicillins, trimethoprim, and sulfonamides was rare and observed in three clones that were shed at low levels in two cows. This study highlights the fact that the commensal E. coli population, including the STEC population, is host specific, is highly dynamic over a short time frame, and rarely carries antibiotic resistance determinants in the absence of antibiotic treatment. IMPORTANCE The literature about the dynamics of commensal Escherichia coli populations is very scarce. Over 25 days, we followed the total E. coli counts daily and characterized the sampled clones in the feces of four cows from the same herd living in the Hwange District of Zimbabwe. This study deals with the day-to-day dynamics of both quantitative and

  16. The Subtitling of Indigenous Values in the Film Seediq Bale

    Directory of Open Access Journals (Sweden)

    Tzu-yi Elaine Lee

    2016-02-01

    Full Text Available The movie Seediq Bale, directed by Wei Te-Sheng and produced by John Woo, is a Taiwanese historical drama epic film based on the Wushe Incident in 1930. The story depicts the Wushe Incident, which happened in central Taiwan while it was under Japanese rule. Mona Rudao, a then chief of Seediq indigenous village Mahebu, led warriors against Japanese authorities due to the long-term colonial oppression. In response, the Japanese mounted a relentless counter-attack, killing over three hundred Seediq people. Often compared by the media in Taiwan to the films Braveheart and The Last of the Mohicans, the film, released in 2011, is so far the most expensive production in Taiwan cinema history. Different language registers are present in the movie, including Mandarin, Japanese, and the Seediq language; this can be a great challenge for the translator when translating the subtitles into English. Nonetheless, it is believed that ideologies can be manifested in language use. So, the study attempts to disclose the translator¡¦s hidden indigenous ideologies in the English subtitles s/he provided. Moreover, as subtitling translation involves a multiplicity of verbal and non-verbal semiotic modes, those visual and audio elements could also contribute to the final product of subtitle translations. Hence, the study, in addition to the translator¡¦s indigenous ideologies and handling of ethnic issues in translation, also looks at how the translator worked with semiotic modes in designing the subtitles for the target context.

  17. Boomers versus Millennials: Online Media Influence on Media Performance and Candidate Evaluations

    Directory of Open Access Journals (Sweden)

    Terri Towner

    2016-09-01

    Full Text Available Facebook posts, YouTube videos, tweets and wooing political bloggers have become standard practice in marketing political campaigns. Research has demonstrated the effect of new media on a host of politically-related behavior, including political participation, knowledge acquisition, group formation and self-efficacy. Yet, issues related to media trust, media performance and candidate evaluations have not been fully explored. In addition, much of the political marketing research looks exclusively at the Millennial age cohort, ignoring other age groups, particularly Baby Boomers. This case study addresses whether attention to traditional (i.e., television, hard-copy newspapers and radio and online media sources (i.e., political candidate websites, television network websites, online newspapers, Facebook, Twitter, YouTube, Tumblr and political blogs about the 2012 U.S. presidential campaign influences Millennials and Baby Boomers’ media trust and performance ratings, as well as candidate evaluations. Panel surveys were completed by both age cohorts, Millennials (n = 431 and Baby Boomers (n = 360, during the last two weeks of the presidential election. Findings indicate that traditional sources, specifically television, rather than online sources are significantly linked to media trust and performance ratings among both Boomers and Millennials. Attention to traditional media for campaign information predicts Boomers’ candidate evaluations, whereas Millennials’ candidate evaluations are influenced by online sources, such as Facebook and candidate websites.

  18. Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery

    Directory of Open Access Journals (Sweden)

    Kim MS

    2016-12-01

    Full Text Available Min Soo Kim,1,* Dong Woo Yeom,1,* Sung Rae Kim,1 Ho Yub Yoon,1 Chang Hyun Kim,1 Ho Yong Son,1 Jin Han Kim,1 Sangkil Lee,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2College of Pharmacy, Keimyung University, Daegu, South Korea *These authors contributed equally to this work Abstract: A double layer-coated colon-specific drug delivery system (DL-CDDS was developed, which consisted of chitosan (CTN based polymeric subcoating of the core tablet containing citric acid for microclimate acidification, followed by an enteric coating. The polymeric composition ratio of Eudragit E100 and ethyl cellulose and amount of subcoating were optimized using a two-level factorial design method. Drug-release characteristics in terms of dissolution efficiency and controlled-release duration were evaluated in various dissolution media, such as simulated colonic fluid in the presence or absence of CTNase. Microflora activation and a stepwise mechanism for drug release were postulated. Consequently, the optimized DL-CDDS showed drug release in a controlled manner by inhibiting drug release in the stomach and intestine, but releasing the drug gradually in the colon (approximately 40% at 10 hours and 92% at 24 hours in CTNase-supplemented simulated colonic fluid, indicating its feasibility as a novel platform for CDD. Keywords: chitosan, colon-specific delivery, acidification, microflora, factorial design, controlled release

  19. The beneficial effects of honeybee-venom serum on facial wrinkles in humans

    Directory of Open Access Journals (Sweden)

    Han SM

    2015-10-01

    Full Text Available Sang Mi Han,1 In Phyo Hong,1 Soon Ok Woo,1 Sung Nam Chun,2 Kwan Kyu Park,3 Young Mee Nicholls,4 Sok Cheon Pak5 1Department of Agricultural Biology, National Academy of Agricultural Science, Wanju, 2Dong Sung Pharmaceuticals Co Ltd, Seoul, 3Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu, South Korea; 4Manuka Doctor Ltd, Auckland, New Zealand; 5School of Biomedical Sciences, Charles Sturt University, Bathurst, NSW, Australia Abstract: Facial wrinkles are an undesirable outcome caused by extrinsic photodamage and intrinsic aging processes. Currently, no effective strategies are known to prevent facial wrinkles. We assessed the beneficial effects of bee-venom serum on the clinical signs of aging skin. Our results show that bee-venom serum treatment clinically improved facial wrinkles by decreasing total wrinkle area, total wrinkle count, and average wrinkle depth. Therefore, bee-venom serum may be effective for the improvement of skin wrinkles. Keywords: bee venom, wrinkle, area, count, depth

  20. Genetic analysis of plant height in induced mutants of aromatic rice

    International Nuclear Information System (INIS)

    Kole, P.C.

    2005-01-01

    Inheritance of plant height in five gamma-ray induced mutants of aromatic rice cultivar Gobindabhog was studied through 6 x 6 diallel cross and segregation analyses. Diallel analysis revealed presence of additive and non-additive gene action with the preponderance of the latter. Proportion of dominant and recessive alleles was distributed unequally among the parents. The direction of dominance was towards tallness. The number of groups of genes was found to be three. The segregation analysis indicated the role of a single major recessive gene for height reduction in three mutants and, in another mutant, a single major recessive gene with negative modifiers. The other semi-dwarf mutant had two major recessive genes with almost equal effect in height reduction. The mutant allele(s) of the latter two mutants were non-allelic to sd sub(1) gene, which could be used as an alternative source of Dee Gee Woo Gen to widen the genetic diversity in semi-dwarfism [it

  1. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Nanticoke Maryland - Garden City Michigan)

    Science.gov (United States)

    1993-01-01

    If 000" F- I M 0 N It 2 0 , COO" , C3 F- #.- -. 1 l- z (K of I MON 110 Ix < ý- 111 4) 1 Ma" 11 de 0 IX M oc z a E 1 00 a Cj if 0 (L 0 0 z 0 (A all M...occoo* W(DO 00040 OCý (4 N 0 In NOOLnoo OOCý Wo= 000 In 1- 00) Sol M in (0 (a qt 0) UIM "Mol"COCO in -4.4 In cacao WOO .0) In 0) 40.* in In In M M #A 0 in...1U000 l Q1001) In to In0) UIDDB1 onC240N (a1 BiO on1 wmt w"n( q 10,1tod)BAU K 0 0 Z 000 Z0) 1-. x -- I4 14 0c f 40) Z N Z -4 - NIB MCc B 0000 1", In

  2. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Norwich Vermont - Melrose Virginia)

    Science.gov (United States)

    1993-01-01

    4 11 0.:000000000 wo~ 0.000u Woo0 1,000 0 - 0 -j ifw IWcO-I4 1 -4 -4 co 00 co00 NNNN " ( NIB -I."-< ൴ 44< < <(o0(D0(to(D0(o(D0(0 សNC"" is C3 -4 (7...a 0 0 C), CD, a a a 0 0 0 0 a a C. C> (n) C, 10 C> a C> a .0 U) III m I mclco< 11 C.)MMM C,) M C1) M I mc>co<:: Cacao co C43 Coa c Q 0 0 0 10 C. Q Q 0...i LA1)0)0 (-mir-- (c)4c LAA) o a ( De 400 M t-.) --.?-- 1 --4 of a < CON ma 00 o(0 0100 ()a )01C)0m)0000oo0 ;4100 40 <D 004 44 14 0V)CI0000 -4I mm. 1

  3. Use of PROMIS for Patients Undergoing Primary Total Shoulder Arthroplasty.

    Science.gov (United States)

    Dowdle, S Blake; Glass, Natalie; Anthony, Chris A; Hettrich, Carolyn M

    2017-09-01

    The Patient-Reported Outcomes Measurement Information System (PROMIS) consists of question banks for health domains through computer adaptive testing (CAT). For patients with glenohumeral arthritis, (1) there would be high correlation between traditional patient-reported outcome (PRO) measures and the PROMIS upper extremity item bank (PROMIS UE) and PROMIS physical function CAT (PROMIS PF CAT), and (2) PROMIS PF CAT would not demonstrate ceiling effects. Cohort study (diagnosis); Level of evidence, 3. Sixty-one patients with glenohumeral osteoarthritis were included. Each patient completed the American Shoulder and Elbow Surgeons (ASES) assessment form, Marx Shoulder Activity Scale, Short Form-36 physical function scale (SF-36 PF), EuroQol 5 Dimensions (EQ-5D) questionnaire, Western Ontario Osteoarthritis Shoulder (WOOS) index, PROMIS PF CAT, and the PROMIS UE. Correlation was defined as high (>0.7), moderate (0.4-0.6), or weak (0.2-0.3). Significant floor and ceiling effects were present if more than 15% of individuals scored the lowest or highest possible total score on any PRO. The PROMIS PF demonstrated excellent correlation with the SF-36 PF ( r = 0.81, P ceiling or floor effects observed. The mean number of items administered by the PROMIS PRO was 4. These data suggest that for a patient population with operative shoulder osteoarthritis, PROMIS UE and PROMIS PF CAT may be valid alternative PROs. Additionally, PROMIS PF CAT offers a decreased question burden with no ceiling effects.

  4. A Single Recessive Mutated Gene (Sd237-1) Controlling Semi-Dwarf Plant Stature of Rice

    International Nuclear Information System (INIS)

    Sobrizal

    2009-01-01

    Dwarfism is a valuable trait in crop breeding, because it increases lodging resistance and decreases damages due to wind and rain. During the course of this study, a semi-dwarf mutant was successfully induced through 200 Gy gamma ray irradiated KI 237 seeds. KI 237 is a pure line with high yield potency, developed through an Indica-Japonica cross of IR36 / Koshihikari. The selected semi-dwarf plant reached 60 - 62 % of plant height of original plant KI 237 at the mature stage. The length of inter nodes, panicle, and seed were also compared between these two plants. The retardation of the 1 st (uppermost) inter nodes was 24 %, moreover, the retardation of panicle and seed length were only 10 % and 2 %, respectively. The elongation pattern of the inter nodes in this mutant was almost the same as sd1 (Dee-geo-woo-gen), the original parent of the first release modern rice variety, but their performances were different. Based on the segregation analysis in M 2 and M 3 generation it was concluded that this mutant was controlled by a single recessive mutated gene. This gene was designated as sd 237-1 . This mutant should be useful as a genetic resource for the improvement of KI 237 line through back-cross breeding as well as be developed further in breeding program directly to be a new high yielding mutant variety. (author)

  5. Omega-3 fatty acid supplementation can improve both symptoms and signs of dry eye disease

    Directory of Open Access Journals (Sweden)

    Kwon J

    2017-03-01

    Full Text Available Jae-Woo Kwon,1 Sang Beom Han2 1Department of Internal Medicine, 2Department of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, South Korea We read with great interest the article by Gatell-Tortajada1 entitled “Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study”. The prospective large-scale study was undoubtedly well designed and conducted, and the authors should be congratulated for successfully demonstrating that oral omega-3 fatty acid supplementation can be an effective treatment for dry eye symptoms.1The authors showed that supplementation of omega-3 fatty acids improved dry eye signs, such as corneal erosion, tear film breakup time, and conjunctival hyperemia, suggesting that they can reduce ocular surface inflammation and also alleviate dry eye symptoms.1 Rashid et al2 also demonstrated that topical application of omega-3 fatty acids led to a decrease in dry eye signs and inflammatory changes at both cellular and molecular levels.  View original paper by Gatell-Tortajada

  6. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (San Juan California - Yale New Haven Conn)

    Science.gov (United States)

    1993-01-01

    414 -4-- - - 4 4 4 4 N Ř I-. I 00(0 if w0 Coto (0(0(0(000woo 0D0(((000(((0000((000(c(DW-I (0 M of4 0001 0 acca " 00 0 0 0 0 00 0 0 00 0 0 0 0 00 - 0...w l" I"r---0 InNC- (00C -.1~00oC I,-0C 0)00> f7 )(NNN,14NNNN( 1I0 o(0-4 tig>- LL- 000o - Nt ý <U- (0 in -J >(0o In4. 0y) 44 xaCp000000 CL if I(00-4...007 W10 M 1 )-4 -TM f7 - -400 "d N"t, -If N 4 40( N -4NC .4 -4040)0N0040- -ION N l 4-4 in 0 -4 ൏ NIO it xo - 0 NI0 I 0. 1 0 00 -4-4 NOCIA0 -4o N-I -4N

  7. Enhanced therapeutic efficacy of budesonide in experimental colitis with enzyme/pH dual-sensitive polymeric nanoparticles

    Directory of Open Access Journals (Sweden)

    Naeem M

    2015-07-01

    Full Text Available Muhammad Naeem, Jiafu Cao, Moonjeong Choi, Woo Seong Kim, Hyung Ryong Moon, Bok Luel Lee, Min-Soo Kim, Yunjin Jung, Jin-Wook Yoo College of Pharmacy, Pusan National University, Busan, South Korea Abstract: Current colon-targeted drug-delivery approaches for colitis therapy often utilize single pH-triggered systems, which are less reliable due to the variation of gut pH in individuals and in disease conditions. Herein, we prepared budesonide-loaded dual-sensitive nanoparticles using enzyme-sensitive azo-polyurethane and pH-sensitive methacrylate copolymer for the treatment of colitis. The therapeutic potential of the enzyme/pH dual-sensitive nanoparticles was evaluated using a rat colitis model and compared to single pH-triggered nanoparticles. Clinical activity scores, colon/body weight ratios, myeloperoxidase activity, and proinflammatory cytokine levels were markedly decreased by dual-sensitive nanoparticles compared to single pH-triggered nanoparticles and budesonide solution. Moreover, dual-sensitive nanoparticles accumulated selectively in inflamed segments of the colon. In addition, dual-sensitive nanoparticle plasma concentrations were lower than single pH-triggered nanoparticles, and no noticeable in vitro or in vivo toxicity was observed. Our results demonstrate that enzyme/pH dual-sensitive nanoparticles are an effective and safe colon-targeted delivery system for colitis therapy. Keywords: azo-polyurethane, methacrylate copolymer, budesonide, colon-targeted nanoparticles, colitis

  8. Two Wooers and their Sonnets: On Poetic Forms in Romeo and Juliet

    Directory of Open Access Journals (Sweden)

    Elena V. Haltrin-Khalturina

    2017-09-01

    Full Text Available The article looks at the semiotics of the sonnet form used by Shakespeare in his tragedy Romeo and Juliet. Particular attention is paid to two sonnets, of Paris and of Romeo, in which different manners of courting are played out. The poetic “gift” from Romeo to Juliet, their shared sonnets, one complete and one interrupted (Act 1, Sc. 5, ls. 92–109, is a notorious and much discussed piece of Shakespeare’s dramatic poetry. However, the other wooing sonnet representing desires of Paris and mouthed by Lady Capulet (Act 1, Sc. 3, ls. 80–95, seems to lack that kind of attention. Our essay juxtaposes the two sonnets in question, which are built around extended metaphors (conceits. Romeo’s sonneteering is endowed with dramatic power that quickens the debate and inspires accord between the title’s heroes. The semantic charge of this shared sonnet resonates in the heroes’ scenic gestures, prompting the play’s outcome. By contrast, the rather inert sonnet of Paris is like a dead letter of bookish instruction, which neither inspires amorous response, nor moves Juliet. The article also places Romeo’s and Paris’s pieces against Shakespeare’s sonnets 128 and 126 of the 1609 edition.

  9. Predictors of premature discontinuation of outpatient treatment after discharge of patients with posttraumatic stress disorder

    Directory of Open Access Journals (Sweden)

    Wang HR

    2015-03-01

    Full Text Available Hee Ryung Wang, Young Sup Woo, Tae-Youn Jun, Won-Myong Bahk Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea Objective: This study aimed to examine the sociodemographic and disease-related variables associated with the premature discontinuation of psychiatric outpatient treatment after discharge among patients with noncombat-related posttraumatic stress disorder. Methods: We retrospectively reviewed the medical records of patients who were discharged with a diagnosis of posttraumatic stress disorder. Results: Fifty-five percent of subjects (57/104 prematurely discontinued outpatient treatment within 6 months of discharge. Comparing sociodemographic variables between the 6-month non-follow-up group and 6-month follow-up group, there were no variables that differed between the two groups. However, comparing disease-related variables, the 6-month follow-up group showed a longer hospitalization duration and higher Global Assessment of Function score at discharge. The logistic regression analysis showed that a shorter duration of hospitalization predicted premature discontinuation of outpatient treatment within 6 months of discharge. Conclusion: The duration of psychiatric hospitalization for posttraumatic stress disorder appeared to influence the premature discontinuation of outpatient treatment after discharge. Keywords: posttraumatic stress disorder, discontinuation, compliance, predictor

  10. An expanding sexual economy along National Route 3 in Luang Namtha Province, Lao PDR.

    Science.gov (United States)

    Doussantousse, Serge; Sakounnavong, Bounchanh; Patterson, Ian

    2011-12-01

    With some of the lowest development indicators in Southeast Asia, remote upland areas of the Lao People's Democratic Republic are among the poorest in the region. The advent of improved transport and communication links, along with opportunities for wage employment, have accelerated the growth of a cash economy in traditionally isolated farming communities of Luang Namtha Province. Interviews and focus group discussions with young people, women in the sexual service business and health workers indicate that the lure of the new economy is wooing villagers away from their agrarian roots. Motorbikes and mobile phones have expanded the sexual territory of indigenous youth at a time when international commerce and a cash economy along improved highways are bringing new people into the region. Among the concerns for their health and safety are at-risk behaviours involving alcohol and sexual practices, especially HIV and sexually transmitted infections. Of particular concern is the sexual trade in the province with a predominance of young, poorly educated Khmou women providing sexual services in a growing number of entertainment places.

  11. Multiple cues on the physiochemical, mesenchymal, and intracellular trafficking interactions with nanocarriers to maximize tumor target efficiency

    Directory of Open Access Journals (Sweden)

    Kim SW

    2015-06-01

    Full Text Available Sang-Woo Kim, Dongwoo Khang Nanomedicine Laboratory, Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, South Korea Abstract: Over the past 60 years, numerous medical strategies have been employed to overcome neoplasms. In fact, with the exception of lung, bronchial, and pancreatic cancers, the 5-year survival rate of most cancers currently exceeds 70%. However, the quality of life of patients during chemotherapy remains unsatisfactory despite the increase in survival rate. The side effects of current chemotherapies stem from poor target efficiency at tumor sites due to the uncontrolled biodistribution of anticancer agents (ie, conventional or current approved nanodrugs. This review discusses the effective physiochemical factors for determining biodistribution of nanocarriers and, ultimately, increasing tumor-targeting probability by avoiding the reticuloendothelial system. Second, stem cell-conjugated nanotherapeutics was addressed to maximize the tumor searching ability and to inhibit tumor growth. Lastly, physicochemical material properties of anticancer nanodrugs were discussed for targeting cellular organelles with modulation of drug-release time. A better understanding of suggested topics will increase the tumor-targeting ability of anticancer drugs and, ultimately, promote the quality of life of cancer patients during chemotherapy. Keywords: cancer, anticancer nanodrugs, mesenchymal stem cell, intracellular trafficking

  12. Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

    KAUST Repository

    Woo, Yong

    2015-07-15

    The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis, free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellular proteins, components of a motility apparatus, and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus, supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga. © Woo et al.

  13. SIMULATION OF COOLING TOWER AND INFLUENCE OF AERODYNAMIC ELEMENTS ON ITS WORK UNDER CONDITIONS OF WIND

    Directory of Open Access Journals (Sweden)

    K. V. Dobrego

    2014-01-01

    Full Text Available Modern Cooling Towers (CT may utilize different aerodynamic elements (deflectors, windbreak walls etc. aimed to improvement of its heat performance especially at the windy conditions. In this paper the effect of flow rotation in overshower zone of CT and windbreak walls on a capacity of tower evaporating unit in the windy condition is studied numerically. Geometry of the model corresponds to real Woo-Jin Power station, China. Analogy of heat and mass transfer was used that allowed to consider aerodynamic of one-dimension flow and carried out detailed 3D calculations applying modern PC. Heat transfer coefficient of irrigator and its hydrodynamic resistance were established according to experimental data on total air rate in cooling tower. Numerical model is tested and verified with experimental data.Nonlinear dependence of CT thermal performance on wind velocity is demonstrated with the minimum (critical wind velocity at ucr ~ 8 m/s for simulated system. Application of windbreak walls does not change the value of the critical wind velocity, but may improves performance of cooling unit at moderate and strong wind conditions. Simultaneous usage of windbreak walls and overshower deflectors may increase efficiency up to 20–30 % for the deflectors angle a = 60o. Simulation let one analyze aerodynamic patterns, induced inside cooling tower and homogeneity of velocities’ field in irrigator’s area.Presented results may be helpful for the CT aerodynamic design optimization, particularly, for perspective hybrid type CTs.

  14. Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Claude Ralph - Day Francis O Co. Inc.)

    Science.gov (United States)

    1994-03-01

    4LLAA ( LU AC x 0 m LA (LA 0 x1 (1A)LALLCA(A( AcCA L A 0 ( tALALA01upIc (00.- U1 C(0 (D0 (0’.CD(0 (D (D (D (DW 00 0 (m (m (0CD(D0(m0w(0(20 (D0w Lo(1(0...COVcII N 44444444444 4444444444 N c04 II 44 4444 N 0041 caoacao acca 0i 0o cn I’ ID6 OOCNY 2 N4NrJNNNNNN0 NNNNNNNNNN C3 cO-4 11 L) U0 0 0 0 0 0c 0 0 0 0...0.4 .. 14൰*o0oo 00 0 0 - .4 N 4j H 4 I0cc WOO 004 INN C 10 10 100N04144443(300 t0 I0.4 ffM MN 14 100 N 0YMIn C 0 0 (1 H ma I (fl>( IIO N N NN N 0 4

  15. Anti-nuclear activities and critics concerning nuclear power plant sites

    International Nuclear Information System (INIS)

    Rhee, We-Beg

    2000-01-01

    Korea has dynamic nuclear power expansion programs, operating 16 nuclear units producing 13710 MW in total located on 4 different sites. Last year, nuclear power supplied over 40 % of national total electricity demands. In 1998, Korean government initiated re-designation work investigating circumstance changes to rule out the unnecessary sites in consideration of a long-term power supply. Korean government has determined to expand the Ulchin site and to designate one point of Woolju county as a new candidate site, and ruled out the rest candidate sites at the end of 1998. About such a governmental measure, the two areas show different reactions. Ulchin where nuclear power plant has been operated safely for about 10 years was likely to accept the governmental determination in spite of some opposition and called for several financial supports for local development. WooIju county, however, showed a strong opposition among local environmental groups and autonomous politicians, and they presented a variety of anti-nuclear activities including demonstrations mainly at the neighbouring metropolis, Ulsan city

  16. Exploring the link between depression and accelerated cellular aging: telomeres hold the key

    Directory of Open Access Journals (Sweden)

    Yu R

    2015-12-01

    Full Text Available Ruby Yu, Jean Woo Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, SAR, China Abstract: Accumulating evidence suggests that telomeres may be a marker for biological aging and telomere length may be affected by multifactorial influences, including cumulative exposure to depression. Associations with telomere length have been reported for major depressive disorder, lifetime duration of depression, higher depression severity, and history of depression. The exact underling mechanisms for these associations have yet to be fully elucidated; however, oxidative stress, chronic inflammation, dysregulated hypothalamus-pituitary-adrenal axis, and altered cortisol levels may be important biochemical mediators. These mediators could also be influenced by psychological stress, unhealthy lifestyle behaviors, or other potential factors, such as childhood abuse, post-traumatic stress disorder, and anxiety that are commonly associated with depression. As such, stress reduction and lifestyle interventions that may affect the telomere maintenance system should be considered for individuals with depression.Keywords: depression, telomere length, biomarkers, cellular ageing

  17. Gold nanoparticles promote osteogenic differentiation in human adipose-derived mesenchymal stem cells through the Wnt/β-catenin signaling pathway

    Directory of Open Access Journals (Sweden)

    Choi SY

    2015-07-01

    Full Text Available Seon Young Choi,1 Min Seok Song,1 Pan Dong Ryu,1 Anh Thu Ngoc Lam,2 Sang-Woo Joo,2 So Yeong Lee1 1Laboratory of Veterinary Pharmacology, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, 2Department of Chemistry, Soongsil University, Seoul, South Korea Abstract: Gold nanoparticles (AuNPs are attractive materials for use in biomedicine due to their physical properties. Increasing evidence suggests that several nanoparticles induce the differentiation of human mesenchymal stem cells into osteoblasts and adipocytes. In this study, we hypothesized that chitosan-conjugated AuNPs promote the osteogenic differentiation of human adipose-derived mesenchymal stem cells. For the evaluation of osteogenic differentiation, alizarin red staining, an alamarBlue® assay, and a quantitative real-time polymerase chain reaction analysis were performed. In order to examine specific signaling pathways, immunofluorescence and a western blotting assay were performed. Our results demonstrate that chitosan-conjugated AuNPs increase the deposition of calcium content and the expression of marker genes related to osteogenic differentiation in human adipose-derived mesenchymal stem cells at nontoxic concentrations. These results indicate that chitosan-conjugated AuNPs promote osteogenesis through the Wnt/β-catenin signaling pathway. Therefore, chitosan-conjugated AuNPs can be used as a reagent for promoting bone formation. Keywords: chitosan-conjugated gold nanoparticle, mineralization, nonphosphorylated beta-catenin

  18. Russian and Chinese Policies of Soft Power in the Central Asia (the Case of Kazakhstan

    Directory of Open Access Journals (Sweden)

    Guangzhen Wang

    2015-12-01

    Full Text Available The policy of “soft power” has lost some of its power in the Russian foreign policy, but continues to dominate in the minds of researchers. There are a lot of scientific and journalistic articles on this subject. The notion has already become a kind of trend, not only in the field of international relations and in the field of political science. The key criterion for determining the impact of “soft power” is “attraction”, that is how the subject can woo the object in order to have some influence on it. Both Russia and China have a set of instruments of “soft power”, which in varying degrees, allow them to influence the objects, including the countries of Central Asia, especially Kazakhstan. Due to the fact that the KR unofficially became the leader of the region, its example can be most clearly trace the desire of Russia and China to become the most attractive partner for Kazakhstan. The study is based on the Comparative Approach, which allows not only to identify the characteristics of the “soft power” of Russia and China, but to compare their effectiveness. The activities of the two countries is analyzed through the prism of tools used in the region of “soft power”, including investment, educational, scientific and cultural programs.

  19. Hearing Mouth Shapes: Sound Symbolism and the Reverse McGurk Effect

    Directory of Open Access Journals (Sweden)

    Charles Spence

    2012-09-01

    Full Text Available In their recent article, Sweeny, Guzman-Martinez, Ortega, Grabowecky, and Suzuki (2012 demonstrate that heard speech sounds modulate the perceived shape of briefly presented visual stimuli. Ovals, whose aspect ratio (relating width to height varied on a trial-by-trial basis, were rated as looking wider when a /woo/ sound was presented, and as taller when a /wee/ sound was presented instead. On the one hand, these findings add to a growing body of evidence demonstrating that audiovisual correspondences can have perceptual (as well as decisional effects. On the other hand, they prompt a question concerning their origin. Although the currently popular view is that crossmodal correspondences are based on the internalization of the natural multisensory statistics of the environment (see Spence, 2011, these new results suggest instead that certain correspondences may actually be based on the sensorimotor responses associated with human vocalizations. As such, the findings of Sweeny et al. help to breathe new life into Sapir's (1929 once-popular “embodied” explanation of sound symbolism. Furthermore, they pose a challenge for those psychologists wanting to determine which among a number of plausible accounts best explains the available data on crossmodal correspondences.

  20. 'Blue Whale Challenge': A Game or Crime?

    Science.gov (United States)

    Mukhra, Richa; Baryah, Neha; Krishan, Kewal; Kanchan, Tanuj

    2017-11-11

    A bewildering range of games are emerging every other day with newer elements of fun and entertainment to woo youngsters. Games are meant to reduce stress and enhance the cognitive development of children as well as adults. Teenagers are always curious to indulge in newer games; and e-gaming is one such platform providing an easy access and quicker means of entertainment. The particular game challenge which has taken the world by storm is the dangerous "Blue Whale Challenge" often involving vulnerable teenagers. The Blue Whale Challenge is neither an application nor internet based game but the users get a link through social media chat groups to enter this "deadly" challenge game. This probably is the only game where the participant has to end his/her life to complete the game. The innocent teenagers are being targeted based on their depressed psychology and are coercively isolated from their social milieux on the pretext of keeping the challenges confidential. To add to the woes, no option is offered to quit the challenge even if the contender is unable to complete the challenge. Blue Whale Challenge in its sheer form could be seen as an illegal, unethical and inhumane endeavor in our present society. The present communication discusses the severe effects of the game on teenagers, the ethical concerns involved and the preventive measures necessary to curb it.

  1. UNRAVELING THE FUNCTIONS OF THE MACROALGAL MICROBIOME

    Directory of Open Access Journals (Sweden)

    Ravindra Pal Singh

    2016-01-01

    Full Text Available Macroalgae are a diverse group of photosynthetic eukaryotic lower organisms and offer indispensable ecosystem services towards sustainable productivity of rocky coastal areas. The earlier studies have mainly focused on elucidation of the roles of the epiphytic bacterial communities in the ecophysiology of the host macroalga. However, mutualistic interactions have become topic of current interest. It is evident from recent studies that a fraction of epiphytic bacterial communities can be categorized as core microbial species, suggesting an obligate association. Epiphytic bacterial communities have also been reported to protect macroalgal surfaces from biofouling microorganisms through production of biologically active metabolites. Because of their intrinsic roles in the host life cycle, the host in turn may provide necessary organic nutrients in order to woo pelagic microbial communities to settle on the host surfaces. However, the precise composition of microbiomes and their functional partnership with hosts are hardly understood. In contrast, the microbial studies associated with human skin and gut and plants have significantly advanced our knowledge on microbiome and their functional interactions with the host. This has led to manipulation of the microbial flora of the human gut and of agricultural plants for improving health and performance. Therefore, it is highly imperative to investigate the functional microbiome that is closely involved in the life cycles of the host macroalgae using high-throughput techniques (metagenomics and metatranscriptomics. The findings from such investigations would help in promoting health and productivity in macroalgal species through regulation of functionally active microbiome.

  2. Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

    KAUST Repository

    Woo, Yong; Ansari, Hifzur Rahman; Otto, Thomas D.; Linger, Christen M K; Olisko, Martin K.; Michá lek, Jan; Saxena, Alka; Shanmugam, Dhanasekaran; Tayyrov, Annageldi; Veluchamy, Alaguraj; Ali, Shahjahan; Bernal, Axel; Del Campo, Javier; Cihlá ř, Jaromí r; Flegontov, Pavel; Gornik, Sebastian G.; Hajdušková , Eva; Horá k, Aleš; Janouškovec, Jan; Katris, Nicholas J.; Mast, Fred D.; Miranda-Saavedra, Diego; Mourier, Tobias; Naeem, Raeece; Nair, Mridul; Panigrahi, Aswini Kumar; Rawlings, Neil D.; Padron Regalado, Eriko; Ramaprasad, Abhinay; Samad, Nadira; Tomčala, Aleš; Wilkes, Jon; Neafsey, Daniel E.; Doerig, Christian; Bowler, Chris; Keeling, Patrick J.; Roos, David S.; Dacks, Joel B.; Templeton, Thomas J.; Waller, Ross F.; Lukeš, Julius; Oborní k, Miroslav; Pain, Arnab

    2015-01-01

    The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis, free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellular proteins, components of a motility apparatus, and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus, supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga. © Woo et al.

  3. All Prime Contract Awards by State or Country, Place, and Contractor. Part 23 (Iceland-TRW INC Classified Location)

    Science.gov (United States)

    1990-01-01

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  4. From crops to products for crops: preserving the ecosystem through the use of bio-based molecules

    Directory of Open Access Journals (Sweden)

    Godard Anaïs

    2016-09-01

    Full Text Available In a context of dwindling oil reserves and environmental pressures, the chemical industry needs to innovate by developing new processes for producing bioproducts from raw plant materials. Unsaturated fatty acids from vegetable oils constitute a highly promising renewable resource that can be used to diversify productions, decreasing reliance on petroleum. A starting material rich in oleic acid has been obtained through the selection of high-oleic sunflower varieties and enzymatic hydrolysis of the oil they produce. The double bonds of this unsaturated raw material have been cleaved in green oxidizing conditions involving a biphasic lipophilic-aqueous system including hydrogen peroxide as an oxidant and a peroxo-tungsten complex Q3 {PO2[WO(O22]4} as a phase-transfer catalyst (PTC and co-oxidant. This PTC efficiently transferred oxygen to the substrate in the lipophilic phase. A mono-acid (pelargonic acid and a di-acid (azelaic acid, with shorter, unusual hydrocarbon chains not present in the natural state, were synthesized and purified through an intensive process. Pelargonic acid was then formulated as an environmentally friendly biocontrol agent for weeds. We extended this green process of oxidative scission to other fatty acids and derivatives, to obtain other short-chain acids with diverse potential applications. This production chain (crops, reaction and purification processes, products, applications is based on a sustainable development strategy.

  5. Candidate genes for COPD: current evidence and research

    Directory of Open Access Journals (Sweden)

    Kim WJ

    2015-10-01

    Full Text Available Woo Jin Kim,1 Sang Do Lee2 1Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon, 2Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea Abstract: COPD is a common complex disease characterized by progressive airflow limitation. Several genome-wide association studies (GWASs have discovered genes that are associated with COPD. Recently, candidate genes for COPD identified by GWASs include CHRNA3/5 (cholinergic nicotine receptor alpha 3/5, IREB2 (iron regulatory binding protein 2, HHIP (hedgehog-interacting protein, FAM13A (family with sequence similarity 13, member A, and AGER (advanced glycosylation end product–specific receptor. Their association with COPD susceptibility has been replicated in multiple populations. Since these candidate genes have not been considered in COPD, their pathological roles are still largely unknown. Herein, we review some evidences that they can be effective drug targets or serve as biomarkers for diagnosis or subtyping. However, more study is required to understand the functional roles of these candidate genes. Future research is needed to characterize the effect of genetic variants, validate gene function in humans and model systems, and elucidate the genes’ transcriptional and posttranscriptional regulatory mechanisms. Keywords: chronic obstructive pulmonary disease, genetics, genome-wide association study

  6. Strategies for changing negative public attitudes toward organ donation in the People's Republic of China

    Directory of Open Access Journals (Sweden)

    Shumin X

    2013-12-01

    Full Text Available Xie Shumin,1 Stephanie Mu-Lian Woo,2 Zhang Lei3 1Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital of Central South University, Changsha, People's Republic of China; 2Harvard University, Cambridge, Massachusetts, USA; 3Department of Thoracic Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China Abstract: In recent decades, the demand for organ transplantation has risen rapidly worldwide, due to an increased incidence of vital organ failure. However, the scarcity of organs appropriate for transplantation has led to an organ shortage crisis. This article retrospectively reviews strategies to change negative public attitudes toward organ donation in the People's Republic of China. We strongly believe that efforts to publicize knowledge of organ donation, promote family discussions, train medical staff and students, establish incentive systems, and implement regulatory oversight may combat unfavorable Chinese public opinion toward organ donation and transplantation, thus potentially increasing the organ donation rate in the People's Republic of China. Keywords: influencing factors, attitudes, organ transplantation, organ failure

  7. Use of PROMIS for Patients Undergoing Primary Total Shoulder Arthroplasty

    Science.gov (United States)

    Dowdle, S. Blake; Glass, Natalie; Anthony, Chris A.; Hettrich, Carolyn M.

    2017-01-01

    Background: The Patient-Reported Outcomes Measurement Information System (PROMIS) consists of question banks for health domains through computer adaptive testing (CAT). Hypothesis: For patients with glenohumeral arthritis, (1) there would be high correlation between traditional patient-reported outcome (PRO) measures and the PROMIS upper extremity item bank (PROMIS UE) and PROMIS physical function CAT (PROMIS PF CAT), and (2) PROMIS PF CAT would not demonstrate ceiling effects. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: Sixty-one patients with glenohumeral osteoarthritis were included. Each patient completed the American Shoulder and Elbow Surgeons (ASES) assessment form, Marx Shoulder Activity Scale, Short Form–36 physical function scale (SF-36 PF), EuroQol 5 Dimensions (EQ-5D) questionnaire, Western Ontario Osteoarthritis Shoulder (WOOS) index, PROMIS PF CAT, and the PROMIS UE. Correlation was defined as high (>0.7), moderate (0.4-0.6), or weak (0.2-0.3). Significant floor and ceiling effects were present if more than 15% of individuals scored the lowest or highest possible total score on any PRO. Results: The PROMIS PF demonstrated excellent correlation with the SF-36 PF (r = 0.81, P ceiling or floor effects observed. The mean number of items administered by the PROMIS PRO was 4. Conclusion: These data suggest that for a patient population with operative shoulder osteoarthritis, PROMIS UE and PROMIS PF CAT may be valid alternative PROs. Additionally, PROMIS PF CAT offers a decreased question burden with no ceiling effects. PMID:28944248

  8. Epidemiology of brucellosis among cattle in Korea from 2001 to 2011

    Science.gov (United States)

    Moon, Oun-Kyong; Lee, Soo-Han; Lee, Won-Chang; Her, Moon; Jeong, Wooseog; Jung, Suk-Chan; Kim, Do-Soon

    2014-01-01

    In the present study, the outbreak patterns of bovine brucellosis in Korea from 2000 to 2011 were analyzed to understand the epidemiological evolution of this disease in the country. A total of 85,521 brucella reactor animals were identified during 14,215 outbreaks over the 12-year study period. The number of bovine brucellosis cases increased after 2003 and peaked in 2006 before decreasing thereafter. The majority of the bovine brucellosis cases were Korean native cattle, Han Woo. The numbers of human brucellosis cases and cattle outbreaks increased and decreased in the same pattern. The correlation coefficient for human and bovine cases per year was 0.96 (95% confidence interval = 0.86~0.99; p brucellosis appeared to be affected by the intensity of eradication programs that mainly involved a test-and-slaughter policy. Findings from the present study were based on freely available statistics from web pages maintained by government agencies. This unlimited access to information demonstrates the usefulness of government statistics for continually monitoring the health of animal populations. PMID:25234321

  9. Biomimetics: forecasting the future of science, engineering, and medicine

    Directory of Open Access Journals (Sweden)

    Hwang J

    2015-09-01

    Full Text Available Jangsun Hwang,1 Yoon Jeong,1,2 Jeong Min Park,3 Kwan Hong Lee,1,2,4 Jong Wook Hong,1,2 Jonghoon Choi1,2 1Department of Bionano Technology, Graduate School, Hanyang University, Seoul, 2Department of Bionano Engineering, Hanyang University ERICA, Ansan, Korea; 3Department of Biomedical Engineering, Boston University, 4OpenView Venture Partners, Boston, MA, USA Abstract: Biomimetics is the study of nature and natural phenomena to understand the principles of underlying mechanisms, to obtain ideas from nature, and to apply concepts that may benefit science, engineering, and medicine. Examples of biomimetic studies include fluid-drag reduction swimsuits inspired by the structure of shark’s skin, velcro fasteners modeled on burrs, shape of airplanes developed from the look of birds, and stable building structures copied from the backbone of turban shells. In this article, we focus on the current research topics in biomimetics and discuss the potential of biomimetics in science, engineering, and medicine. Our report proposes to become a blueprint for accomplishments that can stem from biomimetics in the next 5 years as well as providing insight into their unseen limitations. Keywords: biomimicry, tissue engineering, biomaterials, nature, nanotechnology, nanomedicine

  10. Food Safety Program in Asian Countries.

    Science.gov (United States)

    Yamaguchi, Ryuji; Hwang, Lucy Sun

    2015-01-01

    By using the ILSI network in Asia, we are holding a session focused on food safety programs in several Asian areas. In view of the external environment, it is expected to impact the global food system in the near future, including the rapid increase in food demand and in public health services due to population growth, as well as the threats to biosecurity and food safety due to the rapid globalization of the food trade. Facilitating effective information sharing holds promise for the activation of the food industry. At this session, Prof. Hwang shares the current situation of Food Safety and Sanitation Regulations in Taiwan. Dr. Liu provides a talk on the role of risk assessment in food regulatory control focused on aluminum-containing food additives in China. After the JECFA evaluation of aluminum-containing food additives in 2011, each country has carried out risk assessment based on dietary intake surveys. Ms. Chan reports on the activities of a working group on Food Standards Harmonization in ASEAN. She also explains that the ILSI Southeast Asia Region has actively supported the various ASEAN Working Groups in utilizing science to harmonize food standards. Prof. Park provides current research activities in Korea focused on the effect of climate change on food safety. Climate change is generally seen as having a negative impact on food security, particularly in developing countries. We use these four presentations as a springboard to vigorous discussion on issues related to Food Safety in Asia.

  11. Mobile Authoring of Open Educational Resources as Reusable Learning Objects

    Directory of Open Access Journals (Sweden)

    Dr Kinshuk

    2013-06-01

    Full Text Available E-learning technologies have allowed authoring and playback of standardized reusable learning objects (RLO for several years. Effective mobile learning requires similar functionality at both design time and runtime. Mobile devices can play RLO using applications like SMILE, mobile access to a learning management system (LMS, or other systems which deploy content to mobile learners (Castillo & Ayala, 2008; Chu, Hwang, & Tseng, 2010; Hsu & Chen, 2010; Nakabayashi, 2009; Zualkernan, Nikkhah, & Al-Sabah, 2009. However, implementations which author content in a mobile context do not typically permit reuse across multiple contexts due to a lack of standardization. Standards based (IMS and SCORM authoring implementations exist for non-mobile platforms (Gonzalez-Barbone & Anido-Rifon, 2008; Griffiths, Beauvoir, Liber, & Barrett-Baxendale, 2009; Téllez, 2010; Yang, Chiu, Tsai, & Wu, 2004. However, this paradigm precludes capturing learning where and when it occurs. Consequently, RLO authored for e-learning lack learner generated content, especially with timely, relevant, and location aware examples.

  12. Properties of soya milk and tofu prepared with gamma-irradiated soya beans

    International Nuclear Information System (INIS)

    Byun, M.W.; Kang, I.J.

    1995-01-01

    Soya beans (Glycine max) 'hwang keum' were gamma-irradiated at dose levels of 0, 2 5, 5, 10 and 20 kGy and the effects of the irradiated soya beans on soya milk and tofu properties were studied. An irradiation dose of 5 kGy caused an increase in yield of soya milk and tofu while having very little effect on their quality. The properties of tofu prepared with the soya beans irradiated at 2.5-5 kGy showed no significant difference from the non-irradiated control. However, at higher doses (10-20 kGy), decreases in yield, water holding capacity and sag value of tofu were observed. Compared with the non-irradiated control, hardness and fracturability in the texture of tofu were both significantly increased when the soya bean had been irradiated at 10-20 kGy, while cohesiveness and adhesiveness decreased. The changes in color values of soya milk and tofu were pronounced at 20 kGy

  13. A view of the tip of the iceberg: revisiting conceptual continuities and their implications for science learning

    Science.gov (United States)

    Brown, Bryan A.; Kloser, Matt

    2009-12-01

    We respond to Hwang and Kim and Yeo's critiques of the conceptual continuity framework in science education. First, we address the criticism that their analysis fails to recognize the situated perspective of learning by denying the dichotomy of the formal and informal knowledge as a starting point in the learning process. Second, we address the critique that students' descriptions fail to meet the "gold standard" of science education—alignment with an authoritative source and generalizability—by highlighting some student-expert congruence that could serve as the foundation for future learning. Third, we address the critique that a conceptual continuity framework could lead to less rigorous science education goals by arguing that the ultimate goals do not change, but rather that if the pathways that lead to the goals' achievement could recognize existing lexical continuities' science teaching may become more efficient. In sum, we argue that a conceptual continuities framework provides an asset, not deficit lexical perspective from which science teacher educators and science educators can begin to address and build complete science understandings.

  14. The importance of HIV prevention messaging for orphaned youth in Zimbabwe.

    Science.gov (United States)

    Haney, Erica; Singh, Kavita

    2012-01-01

    The AIDS epidemic has contributed to a drastic increase in the number of orphans in Zimbabwe. Female adolescent orphans are particularly in jeopardy of contracting HIV due to disadvantages including extreme poverty, low education, and the absent of parental oversight which can lead to higher risk-taking sexual behaviors. By understanding where girls receive education about HIV and who they rely on for information, organizations can effectively modify existing programs to better target this at-risk population. For this study a household survey was conducted which included 216 orphans and 324 non-orphans (n=540), aged 12-17 years, in the resource-poor setting of Hwange District, Zimbabwe. The aims of this article were to examine the differences between orphans and non-orphans in HIV prevention message exposure, level of motivation for learning about HIV, and communication with caregivers about safe sex. The household survey revealed that younger orphans, aged 12-15 years, were more motivated to learn about HIV and had greater HIV messaging exposure in school than non-orphans. These exposure and differences in the levels of motivation between groups dissipated at older ages. Our research also discovered less caregiver communication among orphans than non-orphans. Our findings suggest that HIV programs targeting orphans need to do a better job at keeping older orphans interested in HIV prevention at a time when it matters most. Furthermore, intervention strategies that provide caregiver support are instrumental in effectively delivering prevention messages to girls at home.

  15. Adaptive memory: the survival scenario enhances item-specific processing relative to a moving scenario.

    Science.gov (United States)

    Burns, Daniel J; Hart, Joshua; Griffith, Samantha E; Burns, Amy D

    2013-01-01

    Nairne, Thompson, and Pandeirada (2007) found that retention of words rated for their relevance to survival is superior to that of words encoded under numerous other deep processing conditions. They suggested that our memory systems might have evolved to confer an advantage for survival-relevant information. Burns, Burns, and Hwang (2011) suggested a two-process explanation of the proximate mechanisms responsible for the survival advantage. Whereas most control tasks encourage only one type of processing, the survival task encourages both item-specific and relational processing. They found that when control tasks encouraged both types of processing, the survival processing advantage was eliminated. However, none of their control conditions included non-survival scenarios (e.g., moving, vacation, etc.), so it is not clear how this two-process explanation would explain the survival advantage when scenarios are used as control conditions. The present experiments replicated the finding that the survival scenario improves recall relative to a moving scenario in both a between-lists and within-list design and also provided evidence that this difference was accompanied by an item-specific processing difference, not a difference in relational processing. The implications of these results for several existing accounts of the survival processing effect are discussed.

  16. Influence of prey dispersion on territory and group size of African lions: a test of the resource dispersion hypothesis.

    Science.gov (United States)

    Valeix, Marion; Loveridge, Andrew J; MacDonald, David W

    2012-11-01

    Empirical tests of the resource dispersion hypothesis (RDH), a theory to explain group living based on resource heterogeneity, have been complicated by the fact that resource patch dispersion and richness have proved difficult to define and measure in natural systems. Here, we studied the ecology of African lions Panthera leo in Hwange National Park, Zimbabwe, where waterholes are prey hotspots, and where dispersion of water sources and abundance of prey at these water sources are quantifiable. We combined a 10-year data set from GPS-collared lions for which information of group composition was available concurrently with data for herbivore abundance at waterholes. The distance between two neighboring waterholes was a strong determinant of lion home range size, which provides strong support for the RDH prediction that territory size increases as resource patches are more dispersed in the landscape. The mean number of herbivore herds using a waterhole, a good proxy of patch richness, determined the maximum lion group biomass an area can support. This finding suggests that patch richness sets a maximum ceiling on lion group size. This study demonstrates that landscape ecology is a major driver of ranging behavior and suggests that aspects of resource dispersion limit group sizes.

  17. Behavioral adjustments of African herbivores to predation risk by lions: spatiotemporal variations influence habitat use.

    Science.gov (United States)

    Valeix, M; Loveridge, A J; Chamaillé-Jammes, S; Davidson, Z; Murindagomo, F; Fritz, H; Macdonald, D W

    2009-01-01

    Predators may influence their prey populations not only through direct lethal effects, but also through indirect behavioral changes. Here, we combined spatiotemporal fine-scale data from GPS radio collars on lions with habitat use information on 11 African herbivores in Hwange National Park (Zimbabwe) to test whether the risk of predation by lions influenced the distribution of herbivores in the landscape. Effects of long-term risk of predation (likelihood of lion presence calculated over four months) and short-term risk of predation (actual presence of lions in the vicinity in the preceding 24 hours) were contrasted. The long-term risk of predation by lions appeared to influence the distributions of all browsers across the landscape, but not of grazers. This result strongly suggests that browsers and grazers, which face different ecological constraints, are influenced at different spatial and temporal scales in the variation of the risk of predation by lions. The results also show that all herbivores tend to use more open habitats preferentially when lions are in their vicinity, probably an effective anti-predator behavior against such an ambush predator. Behaviorally induced effects of lions may therefore contribute significantly to structuring African herbivore communities, and hence possibly their effects on savanna ecosystems.

  18. Systematic Failure in a Stem Cell Fraud Case by a Poor Quality Culture

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Hyuk Il; Lee, Young Gun; Lim, Nam Jin [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2006-07-01

    In the years 2004 and 2005, Korea became a prospective nation noteworthy in the world through the epochal development of genetic engineering in our country. Obstinate or incurable diseases were expected to be healed in a few years by a Korean geneticist. So many worldwide patients of obstinate or incurable diseases took notice of the research outcomes and organized an aid association to collect supporting funds. World renowned journals such as 'Nature' and 'Science' published Dr. Hwang's theses. A long and distant way remedy to obstinate diseases seemed to be closer at hand so early. However, a stem cell fraud case emerged throughout the world in late 2005, the pride of the Korean people was destroyed. With this as a momentum, voices of self reflection by scientific circles were raised. The purpose of this study is not in finding the truth of the stem cell research but to propose an effective management and control measures for the future in planning, implementing, monitoring and evaluating large scale national R and D projects in order to prevent a recurrence of this kind of failure.

  19. Systematic Failure in a Stem Cell Fraud Case by a Poor Quality Culture

    International Nuclear Information System (INIS)

    Kwon, Hyuk Il; Lee, Young Gun; Lim, Nam Jin

    2006-01-01

    In the years 2004 and 2005, Korea became a prospective nation noteworthy in the world through the epochal development of genetic engineering in our country. Obstinate or incurable diseases were expected to be healed in a few years by a Korean geneticist. So many worldwide patients of obstinate or incurable diseases took notice of the research outcomes and organized an aid association to collect supporting funds. World renowned journals such as 'Nature' and 'Science' published Dr. Hwang's theses. A long and distant way remedy to obstinate diseases seemed to be closer at hand so early. However, a stem cell fraud case emerged throughout the world in late 2005, the pride of the Korean people was destroyed. With this as a momentum, voices of self reflection by scientific circles were raised. The purpose of this study is not in finding the truth of the stem cell research but to propose an effective management and control measures for the future in planning, implementing, monitoring and evaluating large scale national R and D projects in order to prevent a recurrence of this kind of failure

  20. A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells

    Directory of Open Access Journals (Sweden)

    Choi J

    2014-05-01

    Full Text Available Jonghoon Choi,1,2 Mintai P Hwang,3 Jong-Wook Lee,3 Kwan Hyi Lee3,41Institute of Research Strategy and Development (IRSD, Seoul, Republic of Korea; 2Department of Bionano Engineering, Hanyang University, Ansan, Republic of Korea; 3Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea; 4Department of Biomedical Engineering, University of Science and Technology, Seoul, Republic of KoreaAbstract: Mesenchymal stem cells (MSCs have been thought to hold potential as a mode of therapy for immuno-related pathologies, particularly for autoimmune diseases. Despite their potential, the interaction between MSCs and T cells, key players in the pathophysiology of autoimmune diseases, is not yet well understood, thereby preventing further clinical progress. A major obstacle is the highly heterogeneous nature of MSCs in vitro. Unfortunately, bulk assays do not provide information with regard to cell–cell contributions that may play a critical role in the overall cellular response. To address these issues, we investigated the interaction between smaller subsets of MSCs and CD4 T cells in a microwell array. We demonstrate that MSCs appear capable of modulating the T cell proliferation rate in response to persistent cell–cell interactions, and we anticipate the use of our microwell array in the classification of subpopulations within MSCs, ultimately leading to specific therapeutic interventions.Keywords: mesenchymal stem cell, T cell, microwell array

  1. Corneal biomechanical properties after laser-assisted in situ keratomileusis and photorefractive keratectomy

    Directory of Open Access Journals (Sweden)

    Hwang ES

    2017-10-01

    Full Text Available Eileen S Hwang,1 Brian C Stagg,1 Russell Swan,1 Carlton R Fenzl,1 Molly McFadden,2 Valliammai Muthappan,1 Luis Santiago-Caban,1 Mark D Mifflin,1 Majid Moshirfar1,3 1Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, 2Department of Internal Medicine, University of Utah, Salt Lake City, 3HDR Research Center, Hoopes Vision, Draper, UT, USA Background: The purpose of this study was to evaluate the effects of laser-assisted in situ keratomileusis (LASIK and photorefractive keratectomy (PRK on corneal biomechanical properties.Methods: We used the ocular response analyzer to measure corneal hysteresis (CH and corneal resistance factor (CRF before and after refractive surgery.Results: In all, 230 eyes underwent LASIK and 115 eyes underwent PRK without mitomycin C (MMC. Both procedures decreased CH and CRF from baseline. When MMC was used after PRK in 20 eyes, it resulted in lower corneal biomechanical properties at 3 months when compared to the other procedures, but all three procedures had similar values at 12 months.Conclusion: Significant but similar decreases in corneal biomechanical properties after LASIK, PRK without MMC, and PRK with MMC were noted. Keywords: corneal biomechanics, photorefractive keratectomy, laser-assisted in situ keratomileusis, corneal hysteresis, corneal resistance factor, mitomycin C

  2. Converting point-wise nuclear cross sections to pole representation using regularized vector fitting

    Science.gov (United States)

    Peng, Xingjie; Ducru, Pablo; Liu, Shichang; Forget, Benoit; Liang, Jingang; Smith, Kord

    2018-03-01

    Direct Doppler broadening of nuclear cross sections in Monte Carlo codes has been widely sought for coupled reactor simulations. One recent approach proposed analytical broadening using a pole representation of the commonly used resonance models and the introduction of a local windowing scheme to improve performance (Hwang, 1987; Forget et al., 2014; Josey et al., 2015, 2016). This pole representation has been achieved in the past by converting resonance parameters in the evaluation nuclear data library into poles and residues. However, cross sections of some isotopes are only provided as point-wise data in ENDF/B-VII.1 library. To convert these isotopes to pole representation, a recent approach has been proposed using the relaxed vector fitting (RVF) algorithm (Gustavsen and Semlyen, 1999; Gustavsen, 2006; Liu et al., 2018). This approach however needs to specify ahead of time the number of poles. This article addresses this issue by adding a poles and residues filtering step to the RVF procedure. This regularized VF (ReV-Fit) algorithm is shown to efficiently converge the poles close to the physical ones, eliminating most of the superfluous poles, and thus enabling the conversion of point-wise nuclear cross sections.

  3. Diet quality in a wild grazer declines under the threat of an ambush predator.

    Science.gov (United States)

    Barnier, Florian; Valeix, Marion; Duncan, Patrick; Chamaillé-Jammes, Simon; Barre, Philippe; Loveridge, Andrew J; Macdonald, David W; Fritz, Hervé

    2014-06-22

    Predators influence prey populations not only through predation itself, but also indirectly through prompting changes in prey behaviour. The behavioural adjustments of prey to predation risk may carry nutritional costs, but this has seldom been studied in the wild in large mammals. Here, we studied the effects of an ambush predator, the African lion (Panthera leo), on the diet quality of plains zebras (Equus quagga) in Hwange National Park, Zimbabwe. We combined information on movements of both prey and predators, using GPS data, and measurements of faecal crude protein, an index of diet quality in the prey. Zebras which had been in close proximity to lions had a lower quality diet, showing that adjustments in behaviour when lions are within short distance carry nutritional costs. The ultimate fitness cost will depend on the frequency of predator-prey encounters and on whether bottom-up or top-down forces are more important in the prey population. Our finding is the first attempt to our knowledge to assess nutritionally mediated risk effects in a large mammalian prey species under the threat of an ambush predator, and brings support to the hypothesis that the behavioural effects of predation induce important risk effects on prey populations.

  4. A Visual Cryptography Based Watermark Technology for Individual and Group Images

    Directory of Open Access Journals (Sweden)

    Azzam Sleit

    2007-04-01

    Full Text Available The ease by which digital information can be duplicated and distributed has led to the need for effective copyright protection tools. Various techniques including watermarking have been introduced in attempt to address these growing concerns. Most watermarking algorithms call for a piece of information to be hidden directly in media content, in such a way that it is imperceptible to a human observer, but detectable by a computer. This paper presents an improved cryptographic watermark method based on Hwang and Naor-Shamir [1, 2] approaches. The technique does not require that the watermark pattern to be embedded in to the original digital image. Verification information is generated and used to validate the ownership of the image or a group of images. The watermark pattern can be any bitmap image. Experimental results show that the proposed method can recover the watermark pattern from the marked image (or group of images even if major changes are reflected on the original digital image or any member of the image group such as rotation, scaling and distortion.

  5. Penyusunan Tata Kelola Teknologi Informasi Bagi Pemerintah Daerah Menggunakan Framework Cobit 5 (Studi Kasus: Kabupaten Cilacap

    Directory of Open Access Journals (Sweden)

    Annas Wahyu Purwanto

    2013-12-01

    ABSTRACT The failure of the e -government implementation in Indonesia according to Junseok Hwang and Irfan Syamsudin, who were doing research in South Sulawesi, are from the government, not from the people.  Meanwhile in Cilacap District,  Long Term Development Plan for the period 2005-2025 mentioned that e-government in Cilacap already implemented but not optimal yet. Cole methodology used in this study consists of 4 (four stages: problem identification , intervention , evaluation and reflection and learning. Conduct a gap analysis and risk analysis to determine the priorities that need to be carried out in Cilacap Kabupaten. To pursue a level of capability gaps that occur and mitigate the risks that may arise, Cilacap necessary to establish an organizational structure of information technology (IT, convey the purpose and management direction to stakeholders, understanding the direction of government development, develop a vision of the IT architecture governance, maintain the availability of the IT staff, identify IT personnel key, maintain the skills and competency of IT personnel, evaluate the performance achievement of IT personnel and also planning  and mapping of IT human resources .

  6. Development of a new magnetic circuit for slim microspeakers

    Science.gov (United States)

    Lee, Chang-Min; Kwon, Joong-Hak; Hwang, Gun-Yong; Hwang, Sang-Moon

    2009-04-01

    In the minimultimedia market, functional diversity, high performance, and design are given top priority. Lightweight mobile phones of unique design especially attract customer interest and are usually considered to be highly competitive items in the marketplace. Therefore, mobile phones need wider and thinner liquid crystal displays and smaller microspeakers with high acoustic performance. There are two main directions for development of slim microspeakers. One is reducing the thickness, and the other is reducing the width. In the case of reducing the width, the total magnet volume is maintained through extending the length of the magnet circuit [S. M. Hwang et al., IEEE Trans. Magn. 39, 2003 (2003)]. In contrast, reducing the thickness results in a reduction in total magnet volume unless width is increased, which causes many difficulties in the manufacturing process. In this paper, we introduce a new magnetic circuit for slim microspeakers. This new magnetic circuit, which excludes the top plate, makes it possible to manufacture slimmer microspeakers more cost-effectively without any loss of acoustic performance.

  7. Dielectric-filled radiofrequency linacs

    Energy Technology Data Exchange (ETDEWEB)

    Faehl, R J; Keinigs, R K; Pogue, E W [Los Alamos National Lab., NM (United States)

    1997-12-31

    High current, high brightness electron beam accelerators promise to open up dramatic new applications. Linear induction accelerators are currently viewed as the appropriate technology for these applications. A concept by Humphries and Hwang may permit radiofrequency accelerators to fulfill the same functions with greater simplicity and enhanced flexibility. This concept involves the replacement of vacuum rf cavities with dielectric filled ones. Simple analysis indicates that the resonant frequencies are reduced by a factor of ({epsilon}{sub 0}/{epsilon}){sup 1/2} while the stored energy is increased by {epsilon}/{epsilon}{sub 0}. For a high dielectric constant like water, this factor can approach 80. A series of numerical calculations of simple pill-box cavities was performed. Eigenfunctions and resonant frequencies for a full system configuration, including dielectric material, vacuum beamline, and a ceramic window separating the two have been computed. These calculations are compared with the results of a small experimental cavity which have been constructed and operated. Low power tests show excellent agreement. (author). 4 figs., 8 refs.

  8. From bad to worse: when lung cancer complicates idiopathic pulmonary fibrosis.

    Science.gov (United States)

    Strock, Stephen B; Alder, Jonathan K; Kass, Daniel J

    2018-04-01

    Patients with idiopathic pulmonary fibrosis have a significantly increased risk for the development of lung cancer. The morbidity and mortality of this disease combination are substantial, and, unfortunately, there are currently few data to help guide clinicians in its diagnosis and treatment. In a recent issue of this journal, Hwang et al presented one of the first studies to evaluate lung cancer in patients with idiopathic pulmonary fibrosis at the molecular level. They demonstrate variants in regulators of the cell cycle, which are known to be important in malignant transformation and may also be important in the pathogenesis of idiopathic pulmonary fibrosis. Further understanding of the pathogenic overlap between lung cancer and idiopathic pulmonary fibrosis could help point the direction to specific diagnostic modalities and targeted treatment of both conditions in the future. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  9. Improved estimation of the noncentrality parameter distribution from a large number of t-statistics, with applications to false discovery rate estimation in microarray data analysis.

    Science.gov (United States)

    Qu, Long; Nettleton, Dan; Dekkers, Jack C M

    2012-12-01

    Given a large number of t-statistics, we consider the problem of approximating the distribution of noncentrality parameters (NCPs) by a continuous density. This problem is closely related to the control of false discovery rates (FDR) in massive hypothesis testing applications, e.g., microarray gene expression analysis. Our methodology is similar to, but improves upon, the existing approach by Ruppert, Nettleton, and Hwang (2007, Biometrics, 63, 483-495). We provide parametric, nonparametric, and semiparametric estimators for the distribution of NCPs, as well as estimates of the FDR and local FDR. In the parametric situation, we assume that the NCPs follow a distribution that leads to an analytically available marginal distribution for the test statistics. In the nonparametric situation, we use convex combinations of basis density functions to estimate the density of the NCPs. A sequential quadratic programming procedure is developed to maximize the penalized likelihood. The smoothing parameter is selected with the approximate network information criterion. A semiparametric estimator is also developed to combine both parametric and nonparametric fits. Simulations show that, under a variety of situations, our density estimates are closer to the underlying truth and our FDR estimates are improved compared with alternative methods. Data-based simulations and the analyses of two microarray datasets are used to evaluate the performance in realistic situations. © 2012, The International Biometric Society.

  10. Elastocaloric cooling materials and systems

    Science.gov (United States)

    Takeuchi, Ichiro

    2015-03-01

    We are actively pursuing applications of thermoelastic (elastocaloric) cooling using shape memory alloys. Latent heat associated with martensitic transformation of shape memory alloys can be used to run cooling cycles with stress-inducing mechanical drives. The coefficient of performance of thermoelastic cooling materials can be as high as 11 with the directly measured DT of around 17 °C. Depending on the stress application mode, the number of cycles to fatigue can be as large as of the order of 105. Efforts to design and develop thermoelastic alloys with long fatigue life will be discussed. The current project at the University of Maryland is focused on development of building air-conditioners, and at Maryland Energy and Sensor Technologies, smaller scale commercial applications are being pursued. This work is carried out in collaboration with Jun Cui, Yiming Wu, Suxin Qian, Yunho Hwang, Jan Muehlbauer, and Reinhard Radermacher, and it is funded by the ARPA-E BEETIT program and the State of Maryland.

  11. The tensor structure on the representation category of the Wp triplet algebra

    International Nuclear Information System (INIS)

    Tsuchiya, Akihiro; Wood, Simon

    2013-01-01

    We study the braided monoidal structure that the fusion product induces on the Abelian category W p -mod, the category of representations of the triplet W-algebra W p . The W p -algebras are a family of vertex operator algebras that form the simplest known examples of symmetry algebras of logarithmic conformal field theories. We formalize the methods for computing fusion products, developed by Nahm, Gaberdiel and Kausch, that are widely used in the physics literature and illustrate a systematic approach to calculating fusion products in non-semi-simple representation categories. We apply these methods to the braided monoidal structure of W p -mod, previously constructed by Huang, Lepowsky and Zhang, to prove that this braided monoidal structure is rigid. The rigidity of W p -mod allows us to prove explicit formulae for the fusion product on the set of all simple and all projective W p -modules, which were first conjectured by Fuchs, Hwang, Semikhatov and Tipunin; and Gaberdiel and Runkel. (paper)

  12. Onset condition of the off take from the stratified region to the branch with arbitrary direction

    International Nuclear Information System (INIS)

    Lee, Jae Young; Choo, Kyo Seong; Kim, Man Woong

    2004-01-01

    Two phase discharge from a stratified region through single or multiple branches has been studied considerably in the past two decades. The flow distribution in the header-feeder system of CANDU(Canada Deuterium and Uranium) reactors during accident scenario is one of good examples of these applications. Recently, the passive safety feature for PWR(Pressurized Water Reactor) introduce the concept of DVI(Direct Vessel Injection) for the emergency core make up. The expected water sweep out phenomena needs careful models including the curvature effect of down comer shell and the multi branches. It has been generally accepted that the onset condition of the off take follows the 2.5 power law, but recently, Lee et al. discussed that the experimental data produced large scattering to the 2.5 power law. Also, the effect of branch angle on the onset point of off take remains still as an unsolved problem. Hwang et al produced the CANDU specific branch angles of 0, +-90, +-36, +-72. The experimental results showed severe deviation from the 2.5 power law and needs mechanistic understanding on these phenomena. In the present paper, we try to develop a general model of onset point including the branch orientation

  13. Comparison of COPD Assessment Test and Clinical COPD Questionnaire to predict the risk of exacerbation

    Directory of Open Access Journals (Sweden)

    Jo YS

    2017-12-01

    Full Text Available Yong Suk Jo,1 Ho Il Yoon,2 Deog Kyeom Kim,3 Chul-Gyu Yoo,1 Chang-Hoon Lee1 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, 3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea Background and objective: Guidelines recommend the use of simple but comprehensive tools such as COPD Assessment Test (CAT and Clinical COPD Questionnaire (CCQ to assess health status in COPD patients. We aimed to compare the ability of CAT and CCQ to predict exacerbation in COPD patients. Methods: We organized a multicenter prospective cohort study that included COPD patients. The relationships between CAT, CCQ, and other clinical measurements were analyzed by correlation analysis, and the impact of CAT and CCQ scores on exacerbation was analyzed by logistic regression analyses and receiver operating characteristic curve. Results: Among 121 COPD patients, CAT and CCQ score correlated with other symptom measures, lung function and exercise capacity as well. Compared with patients who did not experience exacerbation, those who experienced exacerbation (n=45; 38.2% exhibited more severe airflow limitation, were more likely to have a history of exacerbation in the year prior to enrollment, and demonstrated higher CAT scores. CCQ scores were not significantly associated with exacerbations. A CAT score of ≥15 was an independent risk factor for exacerbation (adjusted odds ratio [aOR], 2.40; 95% CI, 1.03–6.50; P=0.04. Furthermore, CAT scores of ≥15 demonstrated an increased predictive ability for exacerbation compared with currently accepted guidelines for the use of CAT (≥10 and CCQ (≥1 in the assessment of COPD

  14. Enzyme-responsive doxorubicin release from dendrimer nanoparticles for anticancer drug delivery

    Directory of Open Access Journals (Sweden)

    Lee SJ

    2015-08-01

    Full Text Available Sang Joon Lee,1,* Young-Il Jeong,2,* Hyung-Kyu Park,3 Dae Hwan Kang,2,4 Jong-Suk Oh,3 Sam-Gyu Lee,5 Hyun Chul Lee31Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju, 2Biomedical Research Institute, Pusan National University Hospital, Busan, 3Department of Microbiology, Chonnam National University Medical School, Gwangju, 4Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Gyeongnam, 5Department of Physical and Rehabilitation Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea*These authors contributed equally to this workBackground: Since cancer cells are normally over-expressed cathepsin B, we synthesized dendrimer-methoxy poly(ethylene glycol (MPEG-doxorubicin (DOX conjugates using a cathepsin B-cleavable peptide for anticancer drug targeting.Methods: Gly-Phe-Leu-Gly peptide was conjugated with the carboxylic acid end groups of a dendrimer, which was then conjugated with MPEG amine and doxorubicin by aid of carbodiimide chemistry (abbreviated as DendGDP. Dendrimer-MPEG-DOX conjugates without Gly-Phe-Leu-Gly peptide linkage was also synthesized for comparison (DendDP. Nanoparticles were then prepared using a dialysis procedure.Results: The synthesized DendGDP was confirmed with 1H nuclear magnetic resonance spectroscopy. The DendDP and DendGDP nanoparticles had a small particle size of less than 200 nm and had a spherical morphology. DendGDP had cathepsin B-sensitive drug release properties while DendDP did not show cathepsin B sensitivity. Further, DendGDP had improved anticancer activity when compared with doxorubicin or DendDP in an in vivo CT26 tumor xenograft model, ie, the volume of the CT26 tumor xenograft was significantly inhibited when compared with xenografts treated with doxorubicin or DendDP nanoparticles. The DendGDP nanoparticles were found to be relatively concentrated in the tumor tissue and

  15. Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes

    Directory of Open Access Journals (Sweden)

    Cho YY

    2014-11-01

    Full Text Available Yong-Yeon Cho,1 Hyeon-Uk Jeong,1 Jeong-Han Kim,2 Hye Suk Lee1 1College of Pharmacy, The Catholic University of Korea, Bucheon, Korea; 2Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea Abstract: Honokiol, 2-(4-hydroxy-3-prop-2-enyl-phenyl-4-prop-2-enyl-phenol, an active component of Magnolia officinalis and Magnolia grandiflora, exerts various pharmacological activities such as antitumorigenic, antioxidative, anti-inflammatory, neurotrophic, and antithrombotic effects. To investigate whether honokiol acts as a perpetrator in drug interactions, messenger ribonucleic acid (mRNA levels of phase I and II drug-metabolizing enzymes, including cytochrome P450 (CYP, UDP-glucuronosyltransferase (UGT, and sulfotransferase 2A1 (SULT2A1, were analyzed by real-time reverse transcription polymerase chain reaction following 48-hour honokiol exposure in three independent cryopreserved human hepatocyte cultures. Honokiol treatment at the highest concentration tested (50 µM increased the CYP2B6 mRNA level and CYP2B6-catalyzed bupropion hydroxylase activity more than two-fold in three different hepatocyte cultures, indicating that honokiol induces CYP2B6 at higher concentrations. However, honokiol treatment (0.5–50 µM did not significantly alter the mRNA levels of phase I enzymes (CYP1A2, CYP3A4, CYP2C8, CYP2C9, and CYP2C19 or phase II enzymes (UGT1A1, UGT1A4, UGT1A9, UGT2B7, and SULT2A1 in cryopreserved human hepatocyte cultures. CYP1A2-catalyzed phenacetin O-deethylase and CYP3A4-catalyzed midazolam 1'-hydroxylase activities were not affected by 48-hour honokiol treatment in cryopreserved human hepatocytes. These results indicate that honokiol is a weak CYP2B6 inducer and is unlikely to increase the metabolism of concomitant CYP2B6 substrates and cause pharmacokinetic-based drug interactions in humans. Keywords: honokiol, human hepatocytes, drug interactions, cytochrome P450, UDP-glucuronosyltransferases

  16. Nano-graphene oxide composite for in vivo imaging

    Directory of Open Access Journals (Sweden)

    Jang SC

    2018-01-01

    Full Text Available Sung-Chan Jang,1,2,* Sung-Min Kang,1,* Jun Young Lee,3,* Seo Yeong Oh,1 AT Ezhil Vilian,4 Ilsong Lee,1,2 Young-Kyu Han,4 Jeong Hoon Park,3 Wan-Seob Cho,5,* Changhyun Roh,2,6 Yun Suk Huh1 1Department of Biological Engineering, Biohybrid Systems Research Center (BSRC, Inha University, Incheon, 2Biotechnology Research Division, 3Radiation Instrumentation Research Division, Advanced Radiation Technology Institute (ARTI, Korea Atomic Energy Research Institute (KAERI, Jeongeup, 4Department of Energy and Materials Engineering, Dongguk University, Seoul, 5Laboratory of Toxicology, Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan, 6Radiation Biotechnology and Applied Radioisotope Science, University of Science and Technology (UST, Daejeon, Republic of Korea *These authors contributed equally to this work Introduction: Positron emission tomography (PET tracers has the potential to revolutionize cancer imaging and diagnosis. PET tracers offer non-invasive quantitative imaging in biotechnology and biomedical applications, but it requires radioisotopes as radioactive imaging tracers or radiopharmaceuticals. Method: This paper reports the synthesis of 18F-nGO-PEG by covalently functionalizing PEG with nano-graphene oxide, and its excellent stability in physiological solutions. Using a green synthesis route, nGO is then functionalized with a biocompatible PEG polymer to acquire high stability in PBS and DMEM. Results and discussion: The radiochemical safety of 18F-nGO-PEG was measured by a reactive oxygen species and cell viability test. The biodistribution of 18F-nGO-PEG could be observed easily by PET, which suggested the significantly high sensitivity tumor uptake of 18F-nGO-PEG and in a tumor bearing CT-26 mouse compared to the control. 18F-nGO-PEG was applied successfully as an efficient radiotracer or drug agent in vivo using PET imaging. This article is expected to assist many researchers in the fabrication of

  17. Music and the Nature: Input of the Czech Composers

    Science.gov (United States)

    Nemec, Vaclav; Nemcova, Lidmila

    2014-05-01

    Slovak mountains. Josef Suk (1874 - 1935): Pohádka léta (A Summer's Tale) - a work for orchestra remembering a relax and consolation in beauties of the Nature. Bohuslav Martinů (1890 - 1959): Otvírání studánek (The Opening of the Springs) - cantata for soli, female chorus and instrumental accompaniment remembering old local customs of purifying water in the wells when spring comes.

  18. Cinema, paesaggio e turismo “andaluzadas”: la Spagna andalusizzata, patrimonio retroproiettato / Cinema, landscape and “andaluzadas” tourism: the Andalusian Spain, a rear-projected heritage

    Directory of Open Access Journals (Sweden)

    Rocío Liáñez Andrades

    2016-05-01

    Full Text Available La Spagna si è proiettata cinematograficamente al turismo internazionale attraverso la sua immagine più pittoresca e singolare: l’Andalusia. In questo modo, anche nelle produzioni realizzate in altre regioni spagnole (Galizia, Madrid, Castiglia-La Mancia, Catalogna compare lo stereotipo più vincolato alla sua immagine romantica secolare.Questa sineddoche identitaria dell'essere spagnolo è stata agevolata dalle istituzioni turistiche, coscienti della loro capacità di attrazione sul turista straniero, e anche dagli stessi spagnoli, che hanno presentato una visione satirica di questo fenomeno di furto di identità nazionale.Per documentare la nostra ipotesi è stata eseguita l’analisi cinematografica (semiotica e di contenuto di una lista di film proposti, produzioni spagnole e coproduzioni con partecipazione o supporto nazionale. Si tratta di produzioni che non esitano a immergersi negli stereotipi più radicati dell’immaginario andaluso, riconoscendoli e riconoscendosi in questi. Ne emerge in questo modo sia la vocazione etnografica e folkloristica delle produzioni destinate alla proiezione internazionale, sia l’impoverimento della suddetta immagine per l’utente nazionale.Quest’articolo percorre le produzioni sopra citate ed espone l’eventuale collegamento di questi “film pasticcio” con film di recente uscita, come Mission: Impossible 2 (John Woo, 2000, Knight and day (James Mangold, 2010 o Zindagi na milegi dobara (Zoya Akhtar, 2012. Spain presented itself in films in order to promote international tourism through its picturesque and unique image: Andalusia. In this way, including in productions that took place in other regions (Galicia, Madrid, Castile-La Mancha, Catalonia, the basic and most cliché Andalusian appears in its romantic and secular image. This identifying synecdoche of “Spanish Identity” was seen as favored by touristic institutions. Aware of their power of attraction over foreign touristic consumers

  19. Association of blood eosinophils and plasma periostin with FEV1 response after 3-month inhaled corticosteroid and long-acting beta2-agonist treatment in stable COPD patients

    Directory of Open Access Journals (Sweden)

    Park HY

    2015-12-01

    Full Text Available Hye Yun Park,1 Hyun Lee,1 Won-Jung Koh,1 Seonwoo Kim,2 Ina Jeong,3 Hyeon-Kyoung Koo,4 Tae-Hyung Kim,5 Jin Woo Kim,6 Woo Jin Kim,7 Yeon-Mok Oh,8 Don D Sin,9 Seong Yong Lim,10,* Sang-Do Lee8,* On behalf of the KOLD Study Group 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 2Biostatistics Team, Samsung Biomedical Research Institute, Seoul, Korea; 3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul, Korea; 4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea; 5Division of Pulmonary and Critical Care Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Gyeonggi-do, Korea; 6Division of Pulmonology, Department of Internal Medicine, Uijeongbu St Mary’s Hospital, Gyunggi-do, Korea; 7Department of Internal Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Korea; 8Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 9Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; 10Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea *These authors contributed equally to this work Background: COPD patients with increased airway eosinophilic inflammation show a favorable response to inhaled corticosteroids (ICS in combination with a long-acting bronchodilator. Recent studies have demonstrated a significant correlation of sputum eosinophilia with blood eosinophils and periostin. We investigated whether high blood eosinophils and plasma periostin were associated

  20. Alpha-synuclein in cutaneous small nerve fibers

    Directory of Open Access Journals (Sweden)

    Siepmann T

    2016-10-01

    Full Text Available Timo Siepmann,1 Ben Min-Woo Illigens,2 Kristian Barlinn1 1Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; 2Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Abstract: Despite progression in the development of pharmacological therapy, treatment of alpha synucleinopathies, such as Parkinson’s disease (PD and some atypical parkinsonism syndromes, is still challenging. To date, our knowledge of the mechanisms whereby the pathological form of alpha-synuclein causes structural and functional damage to the nervous system is limited and, consequently, there is a lack of specific diagnostic tools to evaluate pathology in these patients and differentiate PD from other neurodegenerative proteinopathies. Recent studies indicated that alpha-synuclein deposition in cutaneous small nerve fibers assessed by skin biopsies might be a valid disease marker of PD and facilitate early differentiation of PD from atypical parkinsonism syndromes. This observation is relevant since early diagnosis may enable timely treatment and improve quality of life. However, challenges include the necessity of standardizing immunohistochemical analysis techniques and the identification of potential distinct patterns of intraneural alpha-synuclein deposition among synucleinopathies. In this perspective, we explore the scientific and clinical opportunities arising from alpha-synuclein assessment using skin biopsies. These include elucidation of the peripheral nervous system pathology of PD and other synucleinopathies, identification of novel targets to study response to neuroprotective treatment, and improvement of clinical management. Furthermore, we discuss future challenges in exploring the diagnostic value of skin biopsy assessment for alpha-synuclein deposition and implementing the technique in clinical practice. Keywords: Parkinson’s disease, diagnosis, skin

  1. Prevalence of colorectal adenomatous polyps in patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Chun EM

    2015-05-01

    Full Text Available Eun Mi Chun, Seo Woo Kim, So Yeon Lim Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of Korea Background: Colorectal adenomatous polyps are precancerous lesions of colorectal cancer. The aim of this study was to assess the prevalence of colorectal adenomatous polyps in chronic obstructive pulmonary disease (COPD patients and determine whether COPD is associated with colorectal malignant potential.Methods: Subjects who had undergone post-bronchodilator spirometry and colonoscopy and were 40 years or older were selected from the hospital database. COPD was defined as a spirometry in which the ratio of forced expiratory volume in 1 second (FEV1 and forced vital capacity (FVC is <0.7 in post-bronchodilator spirometry. The non-COPD group was matched for both age and sex, and were defined as having an FEV1, FVC, and FEV1/FVC ≥0.7 in spirometry. Finally, 333 patients were retrospectively reviewed; of this group, 82 patients had COPD.Results: Among the subjects, 201 patients (60% were nonsmokers, while 78 (23% were current smokers. The prevalence of colorectal adenomatous polyps was 39% (98/251 in the non-COPD group and 66% (54/82 in the COPD group. Among 54 patients with adenomatous polyps in the COPD group, 47 had tubular adenoma and seven had villous adenoma. Multiple logistic regression analyses revealed that only COPD patients whom matched to the criteria of COPD by pulmonary function test (odds ratio 2.1, 95% confidence interval: 1.1–3.8; P=0.019 were independently associated with colorectal malignant potential.Conclusion: The risk of colorectal malignant potential in the COPD group was higher than in the non-COPD group. We may suggest that COPD patients should consider regular colonoscopic evaluation to screen for premalignant colon polyps regardless of smoking. Keywords: COPD, colorectal adenomatous polyp, smoking, chronic obstructive pulmonary

  2. Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution

    Directory of Open Access Journals (Sweden)

    Kotagiri N

    2014-05-01

    Full Text Available Nalinikanth Kotagiri,1–4 Jin-Woo Kim1–31Bio/Nano Technology Laboratory, Institute for Nanoscience and Engineering, 2Department of Biological and Agricultural Engineering, 3Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, AR, USA; 4Optical Radiology Laboratory, Department of Radiology, Washington University School of Medicine, St Louis, MO, USAAbstract: Carbon nanotubes (CNTs have recently been in the limelight for their potential role in disease diagnostics and therapeutics, as well as in tissue engineering. Before these medical applications can be realized, there is a need to address issues like opsonization, phagocytosis by macrophages, and sequestration to the liver and spleen for eventual elimination from the body; along with equally important issues such as aqueous solubility, dispersion, biocompatibility, and biofunctionalization. CNTs have not been shown to be able to evade such biological obstacles, which include their nonspecific attachments to cells and other biological components in the bloodstream, before reaching target tissues and cells in vivo. This will eventually determine their longevity in circulation and clearance rate from the body. This review article discusses the current status, challenges, practical strategies, and implementations of coating CNTs with biocompatible and opsonin-resistant moieties, rendering CNTs transparent to opsonins and deceiving the innate immune response to make believe that the CNTs are not foreign. A holistic approach to the development of such "stealth" CNTs is presented, which encompasses not only several biophysicochemical factors that are not limited to surface treatment of CNTs, but also extraneous biological factors such as the protein corona formation that inevitably controls the in vivo fate of the particles. This review also discusses the present and potential applications, along with the future directions, of CNTs and their hybrid

  3. High coronary calcium score and post-procedural CK-MB are noninvasive predictors of coronary stent restenosis

    Directory of Open Access Journals (Sweden)

    Lee JB

    2017-02-01

    Full Text Available Jae-Beom Lee,1 Yun-Seok Choi,2 Woo-Baek Chung,2 Ami Kwon,2 Chul-Soo Park,2 Man-Young Lee2 1Anyang Sam Hospital, 2Division of Cardiology, Department of Internal Medicine, Youido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Purpose: High coronary calcium score (CCS and post-procedural cardiac enzyme may be related with poor outcomes in patients with coronary stent implantation. Methods: A total of 1,072 patients (63.2% male, mean age: 61.7±10.3 years who underwent coronary multi-detect computed tomography at index procedure and follow-up coronary angiography (CAG after drug-eluting stent (DES were divided into two groups: those with and without target lesion revascularization (TLR; >50% reduction in luminal stent diameter or angina symptoms on follow-up CAG. The CCSs for predicting stent revascularization were elucidated. Results: There were no significant differences between the two groups with regard to risk factors. The initial CCS was significantly higher in the TLR group (1,102.4±743.7 vs 345.8±51.05, P=0.04. After adjustment of significant factors for TLR, only CCS and post-procedural creatine kinase MB form (CK-MB elevation were significant predictors of coronary artery TLR. Receiver operation curve revealed that >800 in CCS had 69% in sensitivity and 88% in specificity about predicting the TLR. Conclusion: High CCS with post-procedural CK-MB might be the useful predictors for TLR after DES implantation. Keywords: coronary restenosis, drug-eluting stents, calcium, creatine kinase

  4. The 2002 HBR list. Breakthrough ideas for today's business agenda.

    Science.gov (United States)

    2002-03-01

    In the last year, war broke out, the economy took a nosedive, and an alarming number of businesses went belly up. Thus it is with some urgency that we bring you this year's list of the seven best new business ideas to help you find your way through these complex times. History Returns. Many thought that the fall of the Berlin Wall marked the beginning of a new world order, one in which history didn't matter. But September 11, 2001, put an end to that theory. And it raised serious questions about globalization, security, and strategy. Enter the Everyday Leader--at Last. CEOs are used to getting all the glory, but leaders outside the limelight--middle managers and tempered radicals--are beginning to receive the attention they deserve. The Internet Is Not About You. The real value of the Internet may lie less in connecting individuals than in connecting databases, servers, and devices--a web not of people but of machines. Mind Your Behavior. Behavioral scientists are beginning to be able to accurately predict the ways individuals and crowds will respond to stimuli, and the implications for business are profound. Don't Delight Your Customers Away. Companies have wooed and coddled customers for too long. The truth is, people delight in being teased and are repelled by those who try too hard to befriend them. Games Are for Losers. Financial game playing and verbal politicking are seriously damaging businesses. Honesty is more than an admirable virtue; it's the foundation of every lasting enterprise. Three Cheers for Creativity (Sometimes). Creativity and best-practice replication are fundamentally different undertakings. Managers who mix the two achieve creativity that is merely incremental and replication that is sadly inept.

  5. Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system

    Directory of Open Access Journals (Sweden)

    Yeom DW

    2017-05-01

    Full Text Available Dong Woo Yeom,1,* Bo Ram Chae,2,* Ho Yong Son,1 Jin Han Kim,1 Jun Soo Chae,1 Seh Hyon Song,2 Dongho Oh,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2Daewon Pharm. Co., Ltd, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST, a poorly water-soluble drug, while reducing the total quantity for administration. Poloxamer 407 is a selectable, supersaturating agent for VST-containing SMEDDS composed of 10% Capmul® MCM, 45% Tween® 20, and 45% Transcutol® P. The amounts of SMEDDS and Poloxamer 407 were chosen as formulation variables for a 3-level factorial design. Further optimization was established by weighting different levels of importance on response variables for dissolution and total quantity, resulting in an optimal S-SMEDDS in large quantity (S-SMEDDS_LQ; 352 mg in total and S-SMEDDS in reduced quantity (S-SMEDDS_RQ; 144.6 mg in total. Good agreement was observed between predicted and experimental values for response variables. Consequently, compared with VST powder or suspension and SMEDDS, both S-SMEDDS_LQ and S-SMEDDS_RQ showed excellent in vitro dissolution and in vivo oral bioavailability in rats. The magnitude of dissolution and absorption-enhancing capacities using quantity-based comparisons was in the order S-SMEDDS_RQ > S-SMEDDS_LQ > SMEDDS > VST powder or suspension. Thus, we concluded that, in terms of developing an effective SMEDDS preparation with minimal total quantity, S-SMEDDS_RQ is a promising candidate. Keywords: valsartan, SMEDDS, supersaturation, factorial design, optimization, bio­availability 

  6. Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint

    Directory of Open Access Journals (Sweden)

    Kim SR

    2015-08-01

    Full Text Available Sung Rae Kim,1 Myoung Jin Ho,2 Eugene Lee,3 Joon Woo Lee,3 Young Wook Choi,1 Myung Joo Kang21College of Pharmacy, Chung-Ang University, Dongjak-gu, Seoul, 2College of Pharmacy, Dankook University, Dongnam-gu, Cheonan, Chungnam, 3Department of Radiology, Seoul National University Bundang Hospital, Bundang-gu, Seongnam, Gyeonggi-do, South KoreaAbstract: Positively surface-charged poly(lactide-co-glycolide (PLGA/Eudragit RL nanoparticles (NPs were designed to increase retention time and sustain release profile in joints after intra-articular injection, by forming micrometer-sized electrostatic aggregates with hyaluronic acid, an endogenous anionic polysaccharide found in high amounts in synovial fluid. The cationic NPs consisting of PLGA, Eudragit RL, and polyvinyl alcohol were fabricated by solvent evaporation technique. The NPs were 170.1 nm in size, with a zeta potential of 21.3 mV in phosphate-buffered saline. Hyperspectral imaging (CytoViva® revealed the formation of the micrometer-sized filamentous aggregates upon admixing, due to electrostatic interaction between NPs and the polysaccharides. NPs loaded with a fluorescent probe (1,1'-dioctadecyl-3,3,3',3' tetramethylindotricarbocyanine iodide, DiR displayed a significantly improved retention time in the knee joint, with over 50% preservation of the fluorescent signal 28 days after injection. When DiR solution was injected intra-articularly, the fluorescence levels rapidly decreased to 30% of the initial concentration within 3 days in mice. From these findings, we suggest that PLGA-based cationic NPs could be a promising tool for prolonged delivery of therapeutic agents in joints selectively.Keywords: PLGA, Eudragit RL, hyaluronic acid, cationic nanoparticles, intra-articular injection, electrostatic interaction

  7. E-Cigarette Social Media Messages: A Text Mining Analysis of Marketing and Consumer Conversations on Twitter.

    Science.gov (United States)

    Lazard, Allison J; Saffer, Adam J; Wilcox, Gary B; Chung, Arnold DongWoo; Mackert, Michael S; Bernhardt, Jay M

    2016-12-12

    As the use of electronic cigarettes (e-cigarettes) rises, social media likely influences public awareness and perception of this emerging tobacco product. This study examined the public conversation on Twitter to determine overarching themes and insights for trending topics from commercial and consumer users. Text mining uncovered key patterns and important topics for e-cigarettes on Twitter. SAS Text Miner 12.1 software (SAS Institute Inc) was used for descriptive text mining to reveal the primary topics from tweets collected from March 24, 2015, to July 3, 2015, using a Python script in conjunction with Twitter's streaming application programming interface. A total of 18 keywords related to e-cigarettes were used and resulted in a total of 872,544 tweets that were sorted into overarching themes through a text topic node for tweets (126,127) and retweets (114,451) that represented more than 1% of the conversation. While some of the final themes were marketing-focused, many topics represented diverse proponent and user conversations that included discussion of policies, personal experiences, and the differentiation of e-cigarettes from traditional tobacco, often by pointing to the lack of evidence for the harm or risks of e-cigarettes or taking the position that e-cigarettes should be promoted as smoking cessation devices. These findings reveal that unique, large-scale public conversations are occurring on Twitter alongside e-cigarette advertising and promotion. Proponents and users are turning to social media to share knowledge, experience, and questions about e-cigarette use. Future research should focus on these unique conversations to understand how they influence attitudes towards and use of e-cigarettes. ©Allison J Lazard, Adam J Saffer, Gary B Wilcox, Arnold DongWoo Chung, Michael S Mackert, Jay M Bernhardt. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 12.12.2016.

  8. Variable Mixed Orbital Character in the Photoelectron Angular Distribution of NO_{2}

    Science.gov (United States)

    Laws, Benjamin A.; Cavanagh, Steven J.; Lewis, Brenton R.; Gibson, Stephen T.

    2017-06-01

    NO_{2} a key component of photochemical smog and an important species in the Earth's atmosphere, is an example of a molecule which exhibits significant mixed orbital character in the HOMO. In photoelectron experiments the geometric properties of the parent anion orbital are reflected in the photoelectron angular distribution (PAD), an area of research that has benefited largely from the ability of velocity-map imaging (VMI) to simultaneously record both the energetic and angular information, with 100% collection efficiency. Photoelectron spectra of NO_{2}^{-}, taken over a range of wavelengths (355nm-520nm) with the ANU's VMI spectrometer, reveal an anomalous jump in the anisotropy parameter near threshold. Consequently, the orbital behavior of NO_{2}^{-} appears to be quite different near threshold compared to detachment at higher photon energies. This surprising effect is due to the Wigner Threshold law, which causes p orbital character to dominate the photodetachment cross-section near threshold, before the mixed s/d orbital character becomes significant at higher electron kinetic energies. By extending recent work on binary character models to form a more general expression, the variable mixed orbital character of NO_{2}^{-} is able to be described. This study provides the first multi-wavelength NO_{2} anisotropy data, which is shown to be in decent agreement with much earlier zero-core model predictions of the anisotropy parameter. K. J. Reed, A. H. Zimmerman, H. C. Andersen, and J. I. Brauman, J. Chem. Phys. 64, 1368, (1976). doi:10.1063/1.432404 D. Khuseynov, C. C. Blackstone, L. M. Culberson, and A. Sanov, J. Chem. Phys. 141, 124312, (2014). doi:10.1063/1.4896241 W. B. Clodius, R. M. Stehman, and S. B. Woo, Phys. Rev. A. 28, 760, (1983). doi:10.1103/PhysRevA.28.760 Research supported by the Australian Research Council Discovery Project Grant DP160102585

  9. Application of linear scheduling method (LSM) for nuclear power plant (NPP) construction

    International Nuclear Information System (INIS)

    Kim, Woojoong; Ryu, Dongsoo; Jung, Youngsoo

    2014-01-01

    Highlights: • Mixed use of linear scheduling method with traditional CPM is suggested for NPP. • A methodology for selecting promising areas for LSM application is proposed. • A case-study is conducted to validate the proposed LSM selection methodology. • A case-study of reducing NPP construction duration by using LSM is introduced. - Abstract: According to a forecast, global energy demand is expected to increase by 56% from 2010 to 2040 (EIA, 2013). The nuclear power plant construction market is also growing with sharper competition. In nuclear power plant construction, scheduling is one of the most important functions due to its large size and complexity. Therefore, it is crucial to incorporate the ‘distinct characteristics of construction commodities and the complex characteristics of scheduling techniques’ (Jung and Woo, 2004) when selecting appropriate schedule control methods for nuclear power plant construction. However, among various types of construction scheduling techniques, the traditional critical path method (CPM) has been used most frequently in real-world practice. In this context, the purpose of this paper is to examine the viability and effectiveness of linear scheduling method (LSM) applications for specific areas in nuclear power plant construction. In order to identify the criteria for selecting scheduling techniques, the characteristics of CPM and LSM were compared and analyzed first through a literature review. Distinct characteristics of nuclear power plant construction were then explored by using a case project in order to develop a methodology to select effective areas of LSM application to nuclear power plant construction. Finally, promising areas for actual LSM application are suggested based on the proposed evaluation criteria and the case project. Findings and practical implications are discussed for further implementation

  10. Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Lee JH

    2016-08-01

    Full Text Available Ji Han Lee,1 Won Sang Jung,2 Woo Hee Choi,3 Hyun Kook Lim4 1Washington University in St Louis, St Louis, MO, USA; 2Department of Radiology, 3Department of Nuclear Medicine, 4Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea Objective: Among patients with Alzheimer’s disease (AD, sleep disturbances are common and serious noncognitive symptoms. Previous studies of AD patients have identified deformations in the brain stem, which may play an important role in the regulation of sleep. The aim of this study was to further investigate the relationship between sleep disturbances and alterations in brain stem morphology in AD.Materials and methods: In 44 patients with AD and 40 healthy elderly controls, sleep disturbances were measured using the Neuropsychiatry Inventory sleep subscale. We employed magnetic resonance imaging-based automated segmentation tools to examine the relationship between sleep disturbances and changes in brain stem morphology.Results: Analyses of the data from AD subjects revealed significant correlations between the Neuropsychiatry Inventory sleep-subscale scores and structural alterations in the left posterior lateral region of the brain stem, as well as normalized brain stem volumes. In addition, significant group differences in posterior brain stem morphology were observed between the AD group and the control group.Conclusion: This study is the first to analyze an association between sleep disturbances and brain stem morphology in AD. In line with previous findings, this study lends support to the possibility that brain stem structural abnormalities might be important neurobiological mechanisms underlying sleep disturbances associated with AD. Further longitudinal research is needed to confirm these findings. Keywords: Alzheimer’s disease, sleep, brain stem, MRI, shape analysis

  11. What is a free customer worth? Armchair calculations of nonpaying customers' value can lead to flawed strategies.

    Science.gov (United States)

    Gupta, Sunil; Mela, Carl F

    2008-11-01

    Free customers who are subsidized by paying customers are essential to a vast array of businesses, such as media companies, employment services, and even IT providers. But because they generate revenue only indirectly, figuring out the true value of those customers--and how much attention to devote them--has always been a challenge. Traditional customer-valuation models don't help; they focus exclusively on paying customers and largely ignore network effects, or how customers help draw other customers to a business. Now a new model, devised by professors Gupta, of Harvard Business School, and Mela, of Fuqua School of Business, takes into account not only direct network effects (where buyers attract more buyers or sellers more sellers) but also indirect network effects (where buyers attract more sellers or vice versa) . The model calculates the precise long-term impact of each additional free customer on a company's profits, factoring in the degree to which he or she brings in other customers--whether free or paying--and the ripple effect of those customers. The model helped an online auction house make several critical decisions. The business made its money on fees charged to sellers but recognized that its free customers--its buyers--were valuable, too. As competition heated up, the company worried that it wasn't wooing enough buyers. Using the model, the business discovered that the network effects of buyers were indeed large and that those customers were worth over $1,000 each--much more than had been assumed. Armed with that information, the firm increased its research on buyers, invested more in targeting them with ads, and improved their experience. The model also helped the company identify the effects of various pricing strategies on sellers, showing that they became less price-sensitive over time. As a result, the company raised the fees it charged them as well.

  12. PCI resistant light water reactor fuel cladding

    International Nuclear Information System (INIS)

    Foster, J.P.; Sabol, G.P.

    1988-01-01

    A tubular nuclear fuel element cladding tube is described, the fuel element cladding tube forming the entire fuel element cladding and consisting of: a single continuous wall, the single continuous wall consisting of a single alloy selected from the group consisting of zirconium base alloys, A, B, C, D, and E; the single continuous wall characterized by a cold worked and stress relieved microstructure throughout; wherein the zirconium base alloy A contains 0.2 - 0.6 w/o Sn, 0.03 - 0.11 w/o sum of Fe and Cr, section 600 ppm O and section 1500 ppm total impurities; the zirconium base alloy B contains 0.1 - 0.6 w/oo Sn, 0.04 - 0.24 w/o Fe, 0.05 - 0.15 w/o Cr, section 0.08 w/o Ni, section 600 ppm O and section 1500 ppm total impurities; the zirconium base alloy C contains 1.2 - 1.7 w/o Sn, 0.04 - 0.24 w/o Fe, 0.05 - 0.15 w/o Cr, section 0.08 w/o Ni, section 600 ppm O, and section 1500 ppm total impurities; the zirconium base alloy D contains 0.15 - 0.6 w/o Sn, 0.15 - 0.5 w/o Fe, section 600 ppm O, and section 1500 ppm total impurities; and the zirconium base alloy E contains 0.4 - 0.6 w/o Sn, 0.1 - 0.3 w/o Fe, 0.03 - 0.07 w/o Ni, section 600 ppm O, and section 1500 ppm total impurities

  13. The response and recovery of the Arabidopsis thaliana transcriptome to phosphate starvation

    KAUST Repository

    Woo, Jongchan

    2012-05-03

    Background: Over application of phosphate fertilizers in modern agriculture contaminates waterways and disrupts natural ecosystems. Nevertheless, this is a common practice among farmers, especially in developing countries as abundant fertilizers are believed to boost crop yields. The study of plant phosphate metabolism and its underlying genetic pathways is key to discovering methods of efficient fertilizer usage. The work presented here describes a genome-wide resource on the molecular dynamics underpinning the response and recovery in roots and shoots of Arabidopsis thaliana to phosphate-starvation.Results: Genome-wide profiling by micro- and tiling-arrays (accessible from GEO: GSE34004) revealed minimal overlap between root and shoot transcriptomes suggesting two independent phosphate-starvation regulons. Novel gene expression patterns were detected for over 1000 candidates and were classified as either initial, persistent, or latent responders. Comparative analysis to AtGenExpress identified cohorts of genes co-regulated across multiple stimuli. The hormone ABA displayed a dominant role in regulating many phosphate-responsive candidates. Analysis of co-regulation enabled the determination of specific versus generic members of closely related gene families with respect to phosphate-starvation. Thus, among others, we showed that PHR1-regulated members of closely related phosphate-responsive families (PHT1;1, PHT1;7-9, SPX1-3, and PHO1;H1) display greater specificity to phosphate-starvation than their more generic counterparts. Conclusion: Our results uncover much larger, staged responses to phosphate-starvation than previously described. To our knowledge, this work describes the most complete genome-wide data on plant nutrient stress to-date. 2012 Woo et al.; licensee BioMed Central Ltd.

  14. Summary of the 1. Asian Workshop on the Ethical Dimensions of the Radiological Protection System

    International Nuclear Information System (INIS)

    Cho, Kun-Woo

    2013-01-01

    Kun-Woo Cho gave a panorama of the 1. Asian Workshop held in Daejeon on 27-28 August 2013 and he focused mainly on the results of the discussions carried out within the three Working Groups. In each group the discussion initially addressed on two questions: What issues of radiation protection refer to ethics? What are the ethical values (explicit and implicit), which underlie the system of radiological protection? WG 1 focused on the fact that the RP system includes judgments that refer to ethical values, but they are implicitly and un-clearly presented in the ICRP recommendations; on the dialogues about the foundation, objectives and rationality of RP system, which should be pushed to facilitate the understanding of the system for RP specialists and stakeholders; and on RP culture and wise behaviours vis-a-vis radiation, which should be promoted in the society. WG 2 discussed the need of ethical consideration in the system of radiological protection; the need to revisit whether individual rights to happiness or justice had been respected; the need to provide more rationales to support important judgments in the RP system, and the need to refine the term 'members of the public' to distinguish informed individuals with certain benefit in return. WG 3 noted that strong parallels between bio-ethics and RP ethics exist. It has also agreed that simplicity, education and communication efforts are required in the RP system to overcome public misunderstanding and to enhance acceptability. With respect to the values of RP ethics attention was given to tolerance of people's views, human dignity, justice, respect for persons, beneficence, prudence, understanding/simplicity and well-being. The presentation reported a view of the conclusions obtained from the 1. Asian Workshop focused on communication, well-being, tolerability and acceptability of risk as the main issues addressed

  15. Quasi-linear viscoelastic properties of the human medial patello-femoral ligament.

    Science.gov (United States)

    Criscenti, G; De Maria, C; Sebastiani, E; Tei, M; Placella, G; Speziali, A; Vozzi, G; Cerulli, G

    2015-12-16

    The evaluation of viscoelastic properties of human medial patello-femoral ligament is fundamental to understand its physiological function and contribution as stabilizer for the selection of the methods of repair and reconstruction and for the development of scaffolds with adequate mechanical properties. In this work, 12 human specimens were tested to evaluate the time- and history-dependent non linear viscoelastic properties of human medial patello-femoral ligament using the quasi-linear viscoelastic (QLV) theory formulated by Fung et al. (1972) and modified by Abramowitch and Woo (2004). The five constant of the QLV theory, used to describe the instantaneous elastic response and the reduced relaxation function on stress relaxation experiments, were successfully evaluated. It was found that the constant A was 1.21±0.96MPa and the dimensionless constant B was 26.03±4.16. The magnitude of viscous response, the constant C, was 0.11±0.02 and the initial and late relaxation time constants τ1 and τ2 were 6.32±1.76s and 903.47±504.73s respectively. The total stress relaxation was 32.7±4.7%. To validate our results, the obtained constants were used to evaluate peak stresses from a cyclic stress relaxation test on three different specimens. The theoretically predicted values fit the experimental ones demonstrating that the QLV theory could be used to evaluate the viscoelastic properties of the human medial patello-femoral ligament. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Forensic aspects of sexual harassment.

    Science.gov (United States)

    Rosman, J P; McDonald, J J

    1999-03-01

    Sexual harassment law presents a complex set of issues not only for lawyers but also for psychiatrists in their roles both as evaluators and clinicians. Judge Reinhardt of the US Court of Appeals for the 9th Circuit, summed up these complexities: "We tend these days, far more than in earlier times, to find our friends, lovers, and even mates in the workplace. We ... often discover that our interests and values are closer to those of our colleagues or fellow employees than to those of people we meet in connection with other activities. In short, increased proximity breeds increased volitional sexual activity." On the other hand, he notes that Title VII "entitles individuals to a workplace that is free from the evil of sexual intimidation or repression. It is frequently difficult to reconcile the two competing values." He goes on to ask, "When does a healthy constructive interest in romance become sexual harassment? To what extent is pursuit of a co-worker proper but of a subordinate forbidden? Is wooing or courting a thing of the past? Must a suitor cease his attentions at the first sign of disinterest or resistance? Must there be an express agreement before the person seeking romance may even hold the hand of the subject of his affection? Is it now verboten to steal a kiss? In the workplace? Everywhere? Under all circumstances or only some? Has the art of romantic persuasion lost its charm? Questions relating to love and sex are among the most difficult for society to answer." The US Supreme Court has stressed the need for common sense in evaluating cases of sexual harassment. Perhaps psychiatrists can play a sobering role in developing answers to these questions.

  17. Model study on acidifying wet deposition in East Asia during wintertime

    Science.gov (United States)

    Han, Zhiwei; Ueda, Hiromasa; Sakurai, Tatsuya

    A regional air quality model (RAQM) has been developed and applied together with an aerosol model to investigate the states and characteristics of wet deposition in East Asia in December 2001. Model simulation is performed with monthly based emission inventory [Streets, D.G., Bond, T.C., Carmichael, G.R., Fernandes, S.D., Fu, Q., He, D., Klimont, Z., Nelson, S. M., Tsai, N.Y., Wang, M.Q., Woo, J.-H., Yarber, K.F., 2003. An inventory of gaseous and primary emissions in Asia in the year 2000. Journal of Geophysical Research 108(D21), 8809] and meteorological fields derived from MM5. Model results are compared with extensive monitoring data including relevant gaseous species and ions in precipitation. The validation demonstrates that this model system is able to represent most of the major physical and chemical processes involved in acid deposition and reproduces concentrations reasonably well, within a factor of 2 of observations in general. The study shows that the regions with pH less than 4.5 are mainly located in southwestern China, parts of the Yangtze Delta, the Yellow Sea and the Korean peninsula, indicating wide regions of acid precipitation in East Asia in wintertime. Japan islands mainly exhibit pH values of 4.5-5.0, whereas over wide areas of northern China, pH values are relatively high (⩾5.0) due to neutralization by alkaline materials such as calcium-laden particles and ammonia, which are more abundant in northern China than that in southern China. While acid rain over most of China is still characterized by sulfur-induced type, considerable areas of eastern China and the western Pacific Rim are found to be more affected by nitric acid than sulfuric acid in acidification of precipitation, which is supposed to result from a combined effect of variations in photochemistry and emission, suggesting the increasing importance of NO x emission in these regions.

  18. Application of linear scheduling method (LSM) for nuclear power plant (NPP) construction

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Woojoong, E-mail: minidung@nate.com [Central Research Institute, Korea Hydro and Nuclear Power Co., Ltd, Daejeon 305-343 (Korea, Republic of); Ryu, Dongsoo, E-mail: energyboy@khnp.co.kr [Central Research Institute, Korea Hydro and Nuclear Power Co., Ltd, Daejeon 305-343 (Korea, Republic of); Jung, Youngsoo, E-mail: yjung97@mju.ac.kr [College of Architecture, Myongji University, Yongin 449-728 (Korea, Republic of)

    2014-04-01

    Highlights: • Mixed use of linear scheduling method with traditional CPM is suggested for NPP. • A methodology for selecting promising areas for LSM application is proposed. • A case-study is conducted to validate the proposed LSM selection methodology. • A case-study of reducing NPP construction duration by using LSM is introduced. - Abstract: According to a forecast, global energy demand is expected to increase by 56% from 2010 to 2040 (EIA, 2013). The nuclear power plant construction market is also growing with sharper competition. In nuclear power plant construction, scheduling is one of the most important functions due to its large size and complexity. Therefore, it is crucial to incorporate the ‘distinct characteristics of construction commodities and the complex characteristics of scheduling techniques’ (Jung and Woo, 2004) when selecting appropriate schedule control methods for nuclear power plant construction. However, among various types of construction scheduling techniques, the traditional critical path method (CPM) has been used most frequently in real-world practice. In this context, the purpose of this paper is to examine the viability and effectiveness of linear scheduling method (LSM) applications for specific areas in nuclear power plant construction. In order to identify the criteria for selecting scheduling techniques, the characteristics of CPM and LSM were compared and analyzed first through a literature review. Distinct characteristics of nuclear power plant construction were then explored by using a case project in order to develop a methodology to select effective areas of LSM application to nuclear power plant construction. Finally, promising areas for actual LSM application are suggested based on the proposed evaluation criteria and the case project. Findings and practical implications are discussed for further implementation.

  19. Estimation of health state utilities in breast cancer

    Directory of Open Access Journals (Sweden)

    Kim SH

    2017-03-01

    Full Text Available Seon-Ha Kim,1 Min-Woo Jo,2 Minsu Ock,2 Hyeon-Jeong Lee,2 Jong-Won Lee3,4 1Department of Nursing, College of Nursing, Dankook University, Cheonan, 2Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, 3Department of Breast and Endocrine Surgery, Asan Medical Center, Seoul, 4Department of Surgery, University of Ulsan College of Medicine, Seoul, South Korea Purpose: The aim of this study is to determine the utility of breast cancer health states using the standard gamble (SG and visual analog scale (VAS methods in the Korean general population.Materials and methods: Eight hypothetical breast cancer health states were developed based on patient education material and previous publications. Data from 509 individuals from the Korean general population were used to evaluate breast cancer health states using the VAS and the SG methods, which were obtained via computer-assisted personal interviews. Mean utility values were calculated for each human papillomavirus (HPV-related health state.Results: The rank of health states was identical between two valuation methods. SG values were higher than VAS values in all health states. The utility values derived from SG were 0.801 (noninvasive breast cancer with mastectomy and followed by reconstruction, 0.790 (noninvasive breast cancer with mastectomy only, 0.779 (noninvasive breast cancer with breast-conserving surgery and radiation therapy, 0.731 (invasive breast cancer with surgery, radiation therapy, and/or chemotherapy, 0.610 (locally advanced breast cancer with radical mastectomy with radiation therapy, 0.587 (inoperable locally advanced breast cancer, 0.496 (loco-regional recurrent breast cancer, and 0.352 (metastatic breast cancer.Conclusion: Our findings might be useful for economic evaluation of breast cancer screening and interventions in general populations. Keywords: breast neoplasm, Korea, quality-adjusted life years, quality of life

  20. Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications

    Directory of Open Access Journals (Sweden)

    Amna T

    2014-02-01

    Full Text Available Touseef Amna,1 M Shamshi Hassan,2 Jieun Yang,1 Myung-Seob Khil,2 Ki-Duk Song,3 Jae-Don Oh,3 Inho Hwang1 1Department of Animal Sciences and Biotechnology, 2Department of Organic Materials and Fiber Engineering, Chonbuk National University, Jeonju, South Korea; 3Genomic Informatics Center, Hankyong National University, Anseong, South Korea Abstract: Recently, substantial interest has been generated in using electrospun biomimetic nanofibers of hybrids, particularly organic/inorganic, to engineer different tissues. The present work, for the first time, introduced a unique natural and synthetic hybrid micronanofiber wound dressing, composed of virgin olive oil/copper oxide nanocrystals and polyurethane (PU, developed via facile electrospinning. The as-spun organic/inorganic hybrid micronanofibers were characterized by scanning electron microscopy (SEM, energy dispersive X-ray analysis, X-ray diffraction, electron probe microanalysis, and transmission electron microscopy. The interaction of cells with scaffold was studied by culturing NIH 3T3 fibroblasts on an as-spun hybrid micronanofibrous mat, and viability, proliferation, and growth were assessed. The 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide assay results and SEM observation showed that the hybrid micronanofibrous scaffold was noncytotoxic to fibroblast cell culture and was found to benefit cell attachment and proliferation. Hence our results suggest the potential utilization of as-spun micronanoscaffolds for tissue engineering. Copper oxide–olive oil/PU wound dressing may exert its positive beneficial effects at every stage during wound-healing progression, and these micronanofibers may serve diverse biomedical applications, such as tissue regeneration, damaged skin treatment, wound healing applications, etc. Conclusively, the fabricated olive oil–copper oxide/PU micronanofibers combine the benefits of virgin olive oil and copper oxide, and therefore hold great promise for

  1. An assessment of heat transfer models of water flow in helically coiled tubes based on selected experimental datasets

    International Nuclear Information System (INIS)

    Gou, Junli; Ma, Haifu; Yang, Zijiang; Shan, Jianqiang

    2017-01-01

    Highlights: •A review of heat transfer characteristics for water flow in helically coiled tubes are conducted. •An assessment of heat transfer models under different heat transfer modes in helically coiled tubes are performed. •This work could provide references for the use of the correlations and for further studies. -- Abstract: This paper presents an assessment of the heat transfer models under different heat transfer modes for water flow in helically coiled tubes based on the compiled datasets from the reviewed literatures. For single phase flow, most of the correlations of the heat transfer coefficient can fit well to the experiments. The correlations of Xin-Ebadian, Dravid and Kalb-Seader for laminar flow and those of Seban-McLaughlim, Mori-Nakayama, Xin-Ebadian, Hardik, Rogers-Mayhew, Mikaila-Poskas and El-Genk-Schriener for turbulent flow are recommended. For flow boiling heat transfer, Steiner-Taborek correlation could be utilized to predict the boiling heat transfer coefficients in helically coiled tubes for a relatively wide range of parameters. For dryout quality, the correlations of Hwang et al. and Santini et al. give relatively better predictions than others. However, more accurate correlations for flow boiling heat transfer coefficient and dryout quality need to be developed based on further investigations with wider parameter ranges in the future. The present work could provide references for the investigators for future uses of those correlations and for performing further investigations on the heat transfer characteristics of water flow in helically coiled tubes.

  2. Teaching efficacy of nurses in clinical practice education: A cross-sectional study.

    Science.gov (United States)

    Kim, Eun-Kyeung; Shin, Sujin

    2017-07-01

    Clinical nurses play a vital role in clinical practice education; thus, it is necessary to help clinical nurses have teaching efficacy through the development and application of systematic education programs. To identify nurses' teaching efficacy for clinical education and analyze the influencing factors of teaching efficacy. The study used a cross-sectional design. We used a convenience sample of 263 nurses from two hospitals. Teaching efficacy, general characteristics, and perception of clinical practice education were collected via self-reported questionnaires. Teaching efficacy was measured using Hwang's (2006) questionnaire, while perception of clinical practice education was measured using the Clinical Nurse Teacher Survey developed by Nishioka et al. (2014). Participants completed the questionnaire directly. The collected data were then analyzed using descriptive statistics, t-tests, ANOVAs, and multiple regression analysis with PASW Statistics 18.0. The mean total score of teaching efficacy was 72.5 (range 21-105). The leadership for students subscale had the highest score (3.56±0.59). The factors influencing teaching efficacy were length of clinical career (β=0.26, pteaching efficacy in nurses. Based on these results, nursing educators might need to develop greater confidence in their knowledge and enhance control of their teaching strategies. Nursing schools and hospitals might need to provide greater support and educational opportunities to nurse clinical practice instructors. Furthermore, constructing a system of cooperation between these colleges and educational hospitals, developing programs to enhance teaching efficacy, and identifying the clinical instructor's role are all necessary to promote clinical practice education. Copyright © 2017. Published by Elsevier Ltd.

  3. Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice

    Directory of Open Access Journals (Sweden)

    Lee B

    2017-03-01

    Full Text Available Byunghyuk Lee,1 Eunhee Ko,1 Jiyeon Lee,2 Yuna Jo,1 Hyunju Hwang,1 Tae Sik Goh,1,3 Myungsoo Joo,2 Changwan Hong1 1Department of Anatomy and Cell Biology, Pusan National University School of Medicine, 2Division of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan, 3Department of Orthopedic Surgery, Medical Research Institute, Pusan National University School of Medicine, Busan, South Korea Abstract: Cigarette smoking (CS is a major cause of considerable morbidity and mortality by inducing lung cancer and COPD. COPD, a smoking-related disorder, is closely related to the alteration of immune system and inflammatory processes that are specifically mediated by T cells. Soluble common gamma chain (sγc has recently been identified as a critical regulator of the development and differentiation of T cells. We examined the effects of sγc in a cigarette smoke extract (CSE mouse model. The sγc level in CSE mice serum is significantly downregulated, and the cellularity of lymph node (LN is systemically reduced in the CSE group. Overexpression of sγc enhances the cellularity and IFNγ production of CD8 T cells in LN and also enhances Th1 and Th17 differentiation of CD4 T cells in the respiratory tract. Mechanistically, the downregulation of sγc expression mediated by CSE is required to prevent excessive inflammatory T cell responses. Therefore, our data suggest that sγc may be one of the target molecules for the control of immunopathogenic progresses in COPD. Keywords: COPD, T cell, soluble common gamma chain, cytokine

  4. Seasonal diet and prey preference of the African lion in a waterhole-driven semi-arid savanna.

    Science.gov (United States)

    Davidson, Zeke; Valeix, Marion; Van Kesteren, Freya; Loveridge, Andrew J; Hunt, Jane E; Murindagomo, Felix; Macdonald, David W

    2013-01-01

    Large carnivores inhabiting ecosystems with heterogeneously distributed environmental resources with strong seasonal variations frequently employ opportunistic foraging strategies, often typified by seasonal switches in diet. In semi-arid ecosystems, herbivore distribution is generally more homogeneous in the wet season, when surface water is abundant, than in the dry season when only permanent sources remain. Here, we investigate the seasonal contribution of the different herbivore species, prey preference and distribution of kills (i.e. feeding locations) of African lions in Hwange National Park, Zimbabwe, a semi-arid African savanna structured by artificial waterholes. We used data from 245 kills and 74 faecal samples. Buffalo consistently emerged as the most frequently utilised prey in all seasons by both male (56%) and female (33%) lions, contributing the most to lion dietary biomass. Jacobs' index also revealed that buffalo was the most intensively selected species throughout the year. For female lions, kudu and to a lesser extent the group "medium Bovidae" are the most important secondary prey. This study revealed seasonal patterns in secondary prey consumption by female lions partly based on prey ecology with browsers, such as giraffe and kudu, mainly consumed in the early dry season, and grazers, such as zebra and suids, contributing more to female diet in the late dry season. Further, it revealed the opportunistic hunting behaviour of lions for prey as diverse as elephants and mice, with elephants taken mostly as juveniles at the end of the dry season during droughts. Jacobs' index finally revealed a very strong preference for kills within 2 km from a waterhole for all prey species, except small antelopes, in all seasons. This suggested that surface-water resources form passive traps and contribute to the structuring of lion foraging behaviour.

  5. Improving the Accuracy of a Heliocentric Potential (HCP Prediction Model for the Aviation Radiation Dose

    Directory of Open Access Journals (Sweden)

    Junga Hwang

    2016-12-01

    Full Text Available The space radiation dose over air routes including polar routes should be carefully considered, especially when space weather shows sudden disturbances such as coronal mass ejections (CMEs, flares, and accompanying solar energetic particle events. We recently established a heliocentric potential (HCP prediction model for real-time operation of the CARI-6 and CARI-6M programs. Specifically, the HCP value is used as a critical input value in the CARI-6/6M programs, which estimate the aviation route dose based on the effective dose rate. The CARI-6/6M approach is the most widely used technique, and the programs can be obtained from the U.S. Federal Aviation Administration (FAA. However, HCP values are given at a one month delay on the FAA official webpage, which makes it difficult to obtain real-time information on the aviation route dose. In order to overcome this critical limitation regarding the time delay for space weather customers, we developed a HCP prediction model based on sunspot number variations (Hwang et al. 2015. In this paper, we focus on improvements to our HCP prediction model and update it with neutron monitoring data. We found that the most accurate method to derive the HCP value involves (1 real-time daily sunspot assessments, (2 predictions of the daily HCP by our prediction algorithm, and (3 calculations of the resultant daily effective dose rate. Additionally, we also derived the HCP prediction algorithm in this paper by using ground neutron counts. With the compensation stemming from the use of ground neutron count data, the newly developed HCP prediction model was improved.

  6. Genetic Modification in Human Pluripotent Stem Cells by Homologous Recombination and CRISPR/Cas9 System.

    Science.gov (United States)

    Xue, Haipeng; Wu, Jianbo; Li, Shenglan; Rao, Mahendra S; Liu, Ying

    2016-01-01

    Genetic modification is an indispensable tool to study gene function in normal development and disease. The recent breakthrough of creating human induced pluripotent stem cells (iPSCs) by defined factors (Takahashi et al., Cell 131:861-872, 2007) provides a renewable source of patient autologous cells that not only retain identical genetic information but also give rise to many cell types of the body including neurons and glia. Meanwhile, the rapid advancement of genome modification tools such as gene targeting by homologous recombination (Capecchi, Nat Rev Genet 6:507-512, 2005) and genome editing tools such as CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas (CRISPR-associated) system, TALENs (Transcription activator-like effector nucleases), and ZFNs (Zinc finger nucleases) (Wang et al., Cell 153:910-918, 2013; Mali et al., Science 339:823-826, 2013; Hwang et al., Nat Biotechnol 31:227-229, 2013; Friedland et al., Nat Methods 10(8):741-743, 2013; DiCarlo et al., Nucleic Acids Res 41:4336-4343, 2013; Cong et al., Science 339:819-823, 2013) has greatly accelerated the development of human genome manipulation at the molecular level. This chapter describes the protocols for making neural lineage reporter lines using homologous recombination and the CRISPR/Cas system-mediated genome editing, including construction of targeting vectors, guide RNAs, transfection into hPSCs, and selection and verification of successfully targeted clones. This method can be applied to various needs of hPSC genetic engineering at high efficiency and high reliability.

  7. Qualitative Study to improve integrity of NET : Perspectives of Peer review and Authorship in research ethics

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Hyuk; Min, Byung Joo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2007-10-15

    After Dr. Hwang's Human embryonic stem cell scandal, research ethics stood out as the hot issue in both Korean scientific circles and general public. Science Publishing Group referred the limitation of peer review system and the absence of responsibility of author to one of the causes for the scandal. In order to prevent a similar fraud, Ministry of Science and Technology(MOST) established guidelines for research ethics and integrity in 2006. The guidelines included fabrication, falsification, and plagiarism(FFP) and unfair authorship. MOST committed the authority of administration and supervision to the society and the institutes of research to preserve the research integrity. The society and institute are charged with overseeing the implementation of enacted ethics guidelines. SCI(Scientific Citation Index) holds the guideline of research ethics and canon of the society which were crafted in order to guaranty the integrity and quality of the research. The publication policy pertains submission of articles, authorship and responsibilities of a reviewer. Societies pay attention to the peer review policy because the quality of articles is strongly dependent on the peer review. Nuclear Engineering and Technology (NET) is the journal of Korea Nuclear Society(KNS). NET is registered with SCIE(Science Citation Index Expanded), recently. In addition to the growth in external circulation, the improvement of quality requires the effort of the society to establish a strict peer review system and a fair authorship. The qualitative study on peer review and authorship of NET was put into force to improve the quality of NET. Based on studies and suggestions, the policy focuses on research ethics to improve the integrity of NET.

  8. Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process

    Directory of Open Access Journals (Sweden)

    Kim MS

    2011-11-01

    Full Text Available Min-Soo Kim1, Jeong-Soo Kim1, Hee Jun Park1, Won Kyung Cho1,3, Kwang-Ho Cha1,3, Sung-Joo Hwang2,31College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea, 2College of Pharmacy, 3Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of KoreaBackground: The aim of this study was to improve the physicochemical properties and bioavailability of poorly water-soluble sirolimus via preparation of a solid dispersion of nanoparticles using a supercritical antisolvent (SAS process.Methods: First, excipients for enhancing the stability and solubility of sirolimus were screened. Second, using the SAS process, solid dispersions of sirolimus-polyvinylpyrrolidone (PVP K30 nanoparticles were prepared with or without surfactants such as sodium lauryl sulfate (SLS, tocopheryl propylene glycol succinate, Sucroester 15, Gelucire 50/13, and Myrj 52. A mean particle size of approximately 250 nm was obtained for PVP K30-sirolimus nanoparticles. Solid state characterization, kinetic solubility, powder dissolution, stability, and pharmacokinetics were analyzed in rats.Results: X-ray diffraction, differential scanning calorimetry, and high-pressure liquid chromatography indicated that sirolimus existed in an anhydrous amorphous form within a solid dispersion of nanoparticles and that no degradation occurred after SAS processing. The improved supersaturation and dissolution of sirolimus as a solid dispersion of nanoparticles appeared to be well correlated with enhanced bioavailability of oral sirolimus in rats. With oral administration of a solid dispersion of PVP K30-SLS-sirolimus nanoparticles, the peak concentration and AUC0→12h of sirolimus were increased by approximately 18.3-fold and 15.2-fold, respectively.Conclusion: The results of this study suggest that preparation of PVP K30-sirolimus-surfactant nanoparticles using the SAS process may be a promising approach for improving the bioavailability of sirolimus

  9. Seasonal diet and prey preference of the African lion in a waterhole-driven semi-arid savanna.

    Directory of Open Access Journals (Sweden)

    Zeke Davidson

    Full Text Available Large carnivores inhabiting ecosystems with heterogeneously distributed environmental resources with strong seasonal variations frequently employ opportunistic foraging strategies, often typified by seasonal switches in diet. In semi-arid ecosystems, herbivore distribution is generally more homogeneous in the wet season, when surface water is abundant, than in the dry season when only permanent sources remain. Here, we investigate the seasonal contribution of the different herbivore species, prey preference and distribution of kills (i.e. feeding locations of African lions in Hwange National Park, Zimbabwe, a semi-arid African savanna structured by artificial waterholes. We used data from 245 kills and 74 faecal samples. Buffalo consistently emerged as the most frequently utilised prey in all seasons by both male (56% and female (33% lions, contributing the most to lion dietary biomass. Jacobs' index also revealed that buffalo was the most intensively selected species throughout the year. For female lions, kudu and to a lesser extent the group "medium Bovidae" are the most important secondary prey. This study revealed seasonal patterns in secondary prey consumption by female lions partly based on prey ecology with browsers, such as giraffe and kudu, mainly consumed in the early dry season, and grazers, such as zebra and suids, contributing more to female diet in the late dry season. Further, it revealed the opportunistic hunting behaviour of lions for prey as diverse as elephants and mice, with elephants taken mostly as juveniles at the end of the dry season during droughts. Jacobs' index finally revealed a very strong preference for kills within 2 km from a waterhole for all prey species, except small antelopes, in all seasons. This suggested that surface-water resources form passive traps and contribute to the structuring of lion foraging behaviour.

  10. High performance communication by people with paralysis using an intracortical brain-computer interface

    Science.gov (United States)

    Pandarinath, Chethan; Nuyujukian, Paul; Blabe, Christine H; Sorice, Brittany L; Saab, Jad; Willett, Francis R; Hochberg, Leigh R

    2017-01-01

    Brain-computer interfaces (BCIs) have the potential to restore communication for people with tetraplegia and anarthria by translating neural activity into control signals for assistive communication devices. While previous pre-clinical and clinical studies have demonstrated promising proofs-of-concept (Serruya et al., 2002; Simeral et al., 2011; Bacher et al., 2015; Nuyujukian et al., 2015; Aflalo et al., 2015; Gilja et al., 2015; Jarosiewicz et al., 2015; Wolpaw et al., 1998; Hwang et al., 2012; Spüler et al., 2012; Leuthardt et al., 2004; Taylor et al., 2002; Schalk et al., 2008; Moran, 2010; Brunner et al., 2011; Wang et al., 2013; Townsend and Platsko, 2016; Vansteensel et al., 2016; Nuyujukian et al., 2016; Carmena et al., 2003; Musallam et al., 2004; Santhanam et al., 2006; Hochberg et al., 2006; Ganguly et al., 2011; O’Doherty et al., 2011; Gilja et al., 2012), the performance of human clinical BCI systems is not yet high enough to support widespread adoption by people with physical limitations of speech. Here we report a high-performance intracortical BCI (iBCI) for communication, which was tested by three clinical trial participants with paralysis. The system leveraged advances in decoder design developed in prior pre-clinical and clinical studies (Gilja et al., 2015; Kao et al., 2016; Gilja et al., 2012). For all three participants, performance exceeded previous iBCIs (Bacher et al., 2015; Jarosiewicz et al., 2015) as measured by typing rate (by a factor of 1.4–4.2) and information throughput (by a factor of 2.2–4.0). This high level of performance demonstrates the potential utility of iBCIs as powerful assistive communication devices for people with limited motor function. Clinical Trial No: NCT00912041 DOI: http://dx.doi.org/10.7554/eLife.18554.001 PMID:28220753

  11. A study on making a Honsang using the star catalogue from 『Seong Gyeong』

    Science.gov (United States)

    Ham, Seon Young; Kim, Sang Hyuk; Lee, Yong Sam

    2016-01-01

    The first record of Honsang (Celestial globe) was found in 『Sejong Sillok』 in Korea. Since then, there were records that Honsang was restored during the reign of King Jungjong and King Myungjong, and then restored again in the reign of King Seonjo. The only existing Honsang was made by Yi Hwang (1501-1570) in the 16th century for education of his followers. After then, Hong Dae Yong's (1731-1783) Honsangui, which was made in 18th century, had been passed down only through the literature. The constellations in Honsang and the scale system of each ring changed after 17th century when Western science began to affect Joseon dynasty. Since that time, the constellations, realized on Honsang globe, changed from constellations in the old method to ones in the new method. Furthermore, the scale system of rings on Honsang was changed from 365.25 Do, Jucheondo (Celestial globe circumference), to 360°. In this study, Honsang with constellations in the new method was made using star catalogue from 『Seong Gyeong』 published in 1861, which represented the constellations in the new method of Joseon dynasty. In order to realized the constellations from the star catalogue in 『Seong Gyeong』 on Honsang globe, the plane star chart and circular star chart of the area near the South and North Poles were drawn using spherical trigonometry. Using these star charts, the constellations in whole sky including stars near the South Pole were realized on Honsang globe. Also, equatorial coordinates and ecliptic coordinates were realized on Honsang globe simultaneously, and scales of Honsang's rings were marked as 360°.

  12. Atrial Fibrillation Screening in Nonmetropolitan Areas Using a Telehealth Surveillance System With an Embedded Cloud-Computing Algorithm: Prospective Pilot Study.

    Science.gov (United States)

    Chen, Ying-Hsien; Hung, Chi-Sheng; Huang, Ching-Chang; Hung, Yu-Chien; Hwang, Juey-Jen; Ho, Yi-Lwun

    2017-09-26

    Atrial fibrillation (AF) is a common form of arrhythmia that is associated with increased risk of stroke and mortality. Detecting AF before the first complication occurs is a recognized priority. No previous studies have examined the feasibility of undertaking AF screening using a telehealth surveillance system with an embedded cloud-computing algorithm; we address this issue in this study. The objective of this study was to evaluate the feasibility of AF screening in nonmetropolitan areas using a telehealth surveillance system with an embedded cloud-computing algorithm. We conducted a prospective AF screening study in a nonmetropolitan area using a single-lead electrocardiogram (ECG) recorder. All ECG measurements were reviewed on the telehealth surveillance system and interpreted by the cloud-computing algorithm and a cardiologist. The process of AF screening was evaluated with a satisfaction questionnaire. Between March 11, 2016 and August 31, 2016, 967 ECGs were recorded from 922 residents in nonmetropolitan areas. A total of 22 (2.4%, 22/922) residents with AF were identified by the physician's ECG interpretation, and only 0.2% (2/967) of ECGs contained significant artifacts. The novel cloud-computing algorithm for AF detection had a sensitivity of 95.5% (95% CI 77.2%-99.9%) and specificity of 97.7% (95% CI 96.5%-98.5%). The overall satisfaction score for the process of AF screening was 92.1%. AF screening in nonmetropolitan areas using a telehealth surveillance system with an embedded cloud-computing algorithm is feasible. ©Ying-Hsien Chen, Chi-Sheng Hung, Ching-Chang Huang, Yu-Chien Hung, Juey-Jen Hwang, Yi-Lwun Ho. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 26.09.2017.

  13. Protocol for a between-group experimental study examining cultural differences in emotion processing between Malay and Caucasian adults with and without major depressive disorder.

    Science.gov (United States)

    Mohan, S N; Mukhtar, F; Jobson, L

    2016-10-21

    Depression is a mood disorder that affects a significant proportion of the population worldwide. In Malaysia and Australia, the number of people diagnosed with depression is on the rise. It has been found that impairments in emotion processing and emotion regulation play a role in the development and maintenance of depression. This study is based on Matsumoto and Hwang's biocultural model of emotion and Triandis' Subjective Culture model. It aims to investigate the influence of culture on emotion processing among Malaysians and Australians with and without major depressive disorder (MDD). This study will adopt a between-group design. Participants will include Malaysian Malays and Caucasian Australians with and without MDD (N=320). There will be four tasks involved in this study, namely: (1) the facial emotion recognition task, (2) the biological motion task, (3) the subjective experience task and (4) the emotion meaning task. It is hypothesised that there will be cultural differences in how participants with and without MDD respond to these emotion tasks and that, pan-culturally, MDD will influence accuracy rates in the facial emotion recognition task and the biological motion task. This study is approved by the Universiti Putra Malaysia Research Ethics Committee (JKEUPM) and the Monash University Human Research Ethics Committee (MUHREC). Permission to conduct the study has also been obtained from the National Medical Research Register (NMRR; NMRR-15-2314-26919). On completion of the study, data will be kept by Universiti Putra Malaysia for a specific period of time before they are destroyed. Data will be published in a collective manner in the form of journal articles with no reference to a specific individual. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  14. Protocol for a between-group experimental study examining cultural differences in emotion processing between Malay and Caucasian adults with and without major depressive disorder

    Science.gov (United States)

    Mohan, S N; Mukhtar, F; Jobson, L

    2016-01-01

    Introduction Depression is a mood disorder that affects a significant proportion of the population worldwide. In Malaysia and Australia, the number of people diagnosed with depression is on the rise. It has been found that impairments in emotion processing and emotion regulation play a role in the development and maintenance of depression. This study is based on Matsumoto and Hwang's biocultural model of emotion and Triandis' Subjective Culture model. It aims to investigate the influence of culture on emotion processing among Malaysians and Australians with and without major depressive disorder (MDD). Methods and analysis This study will adopt a between-group design. Participants will include Malaysian Malays and Caucasian Australians with and without MDD (N=320). There will be four tasks involved in this study, namely: (1) the facial emotion recognition task, (2) the biological motion task, (3) the subjective experience task and (4) the emotion meaning task. It is hypothesised that there will be cultural differences in how participants with and without MDD respond to these emotion tasks and that, pan-culturally, MDD will influence accuracy rates in the facial emotion recognition task and the biological motion task. Ethics and dissemination This study is approved by the Universiti Putra Malaysia Research Ethics Committee (JKEUPM) and the Monash University Human Research Ethics Committee (MUHREC). Permission to conduct the study has also been obtained from the National Medical Research Register (NMRR; NMRR-15-2314-26919). On completion of the study, data will be kept by Universiti Putra Malaysia for a specific period of time before they are destroyed. Data will be published in a collective manner in the form of journal articles with no reference to a specific individual. PMID:27798019

  15. Interspecific interference competition at the resource patch scale: do large herbivores spatially avoid elephants while accessing water?

    Science.gov (United States)

    Ferry, Nicolas; Dray, Stéphane; Fritz, Hervé; Valeix, Marion

    2016-11-01

    Animals may anticipate and try to avoid, at some costs, physical encounters with other competitors. This may ultimately impact their foraging distribution and intake rates. Such cryptic interference competition is difficult to measure in the field, and extremely little is known at the interspecific level. We tested the hypothesis that smaller species avoid larger ones because of potential costs of interference competition and hence expected them to segregate from larger competitors at the scale of a resource patch. We assessed fine-scale spatial segregation patterns between three African herbivore species (zebra Equus quagga, kudu Tragelaphus strepsiceros and giraffe Giraffa camelopardalis) and a megaherbivore, the African elephant Loxodonta africana, at the scale of water resource patches in the semi-arid ecosystem of Hwange National Park, Zimbabwe. Nine waterholes were monitored every two weeks during the dry season of a drought year, and observational scans of the spatial distribution of all herbivores were performed every 15 min. We developed a methodological approach to analyse such fine-scale spatial data. Elephants increasingly used waterholes as the dry season progressed, as did the probability of co-occurrence and agonistic interaction with elephants for the three study species. All three species segregated from elephants at the beginning of the dry season, suggesting a spatial avoidance of elephants and the existence of costs of being close to them. However, contrarily to our expectations, herbivores did not segregate from elephants the rest of the dry season but tended to increasingly aggregate with elephants as the dry season progressed. We discuss these surprising results and the existence of a trade-off between avoidance of interspecific interference competition and other potential factors such as access to quality water, which may have relative associated costs that change with the time of the year. © 2016 The Authors. Journal of Animal Ecology

  16. Isolated granulocytic sarcoma of the nasopharynx: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Vishnu P

    2013-12-01

    Full Text Available Prakash Vishnu,1 Ravindra Reddy Chuda,2 Dick G Hwang,3 David M Aboulafia1,4 1Floyd and Delores Jones Cancer Institute at Virginia Mason Medical Center, Seattle, WA, USA; 2Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA; 3Department of Pathology, Virginia Mason Medical Center, 4Division of Hematology, University of Washington, Seattle, WA, USA Abstract: Granulocytic sarcoma (GS is a rare extramedullary manifestation of acute myeloid leukemia (AML. It may also represent blastic transformation of myelodysplastic syndromes or myeloproliferative neoplasms. Although usually seen in the context of advanced and poorly controlled disease, it may also present as the first manifestation of illness, without concurrent bone marrow or blood involvement. In the medical literature, chloroma and GS are terms that have been used interchangeably with myeloid sarcoma. GS usually manifests as soft tissue or bony masses in several extracranial sites, such as bone, periosteum, and lymph nodes; involvement of the head and neck region is uncommon. We report a case of a woman with insidious onset of progressive nasal congestion and diminished hearing who was diagnosed with an isolated GS of the nasopharynx. With involved field radiotherapy, she achieved a complete remission of 12-months duration before being diagnosed with overt AML. She has remained disease-free for greater than 18 months following induction and consolidation chemotherapy. Through a MEDLINE®/PubMed® search we identified an additional 13 cases of nasopharyngeal GS. The median age was 37 years (range 1 to 81 years. The cases were equally distributed among the sexes. The most common presenting symptoms were conductive hearing loss and sinonasal congestion. Isolated GS was identified in six cases, and the median time from diagnosis of GS to AML was 12 months (range 3 to 48 months. The treatment varied, but responses were seen in all the patients who received

  17. Qualitative Study to improve integrity of NET : Perspectives of Peer review and Authorship in research ethics

    International Nuclear Information System (INIS)

    Kwon, Hyuk; Min, Byung Joo

    2007-01-01

    After Dr. Hwang's Human embryonic stem cell scandal, research ethics stood out as the hot issue in both Korean scientific circles and general public. Science Publishing Group referred the limitation of peer review system and the absence of responsibility of author to one of the causes for the scandal. In order to prevent a similar fraud, Ministry of Science and Technology(MOST) established guidelines for research ethics and integrity in 2006. The guidelines included fabrication, falsification, and plagiarism(FFP) and unfair authorship. MOST committed the authority of administration and supervision to the society and the institutes of research to preserve the research integrity. The society and institute are charged with overseeing the implementation of enacted ethics guidelines. SCI(Scientific Citation Index) holds the guideline of research ethics and canon of the society which were crafted in order to guaranty the integrity and quality of the research. The publication policy pertains submission of articles, authorship and responsibilities of a reviewer. Societies pay attention to the peer review policy because the quality of articles is strongly dependent on the peer review. Nuclear Engineering and Technology (NET) is the journal of Korea Nuclear Society(KNS). NET is registered with SCIE(Science Citation Index Expanded), recently. In addition to the growth in external circulation, the improvement of quality requires the effort of the society to establish a strict peer review system and a fair authorship. The qualitative study on peer review and authorship of NET was put into force to improve the quality of NET. Based on studies and suggestions, the policy focuses on research ethics to improve the integrity of NET

  18. Asymptotics of bivariate generating functions with algebraic singularities

    Science.gov (United States)

    Greenwood, Torin

    Flajolet and Odlyzko (1990) derived asymptotic formulae the coefficients of a class of uni- variate generating functions with algebraic singularities. Gao and Richmond (1992) and Hwang (1996, 1998) extended these results to classes of multivariate generating functions, in both cases by reducing to the univariate case. Pemantle and Wilson (2013) outlined new multivariate ana- lytic techniques and used them to analyze the coefficients of rational generating functions. After overviewing these methods, we use them to find asymptotic formulae for the coefficients of a broad class of bivariate generating functions with algebraic singularities. Beginning with the Cauchy integral formula, we explicity deform the contour of integration so that it hugs a set of critical points. The asymptotic contribution to the integral comes from analyzing the integrand near these points, leading to explicit asymptotic formulae. Next, we use this formula to analyze an example from current research. In the following chapter, we apply multivariate analytic techniques to quan- tum walks. Bressler and Pemantle (2007) found a (d + 1)-dimensional rational generating function whose coefficients described the amplitude of a particle at a position in the integer lattice after n steps. Here, the minimal critical points form a curve on the (d + 1)-dimensional unit torus. We find asymptotic formulae for the amplitude of a particle in a given position, normalized by the number of steps n, as n approaches infinity. Each critical point contributes to the asymptotics for a specific normalized position. Using Groebner bases in Maple again, we compute the explicit locations of peak amplitudes. In a scaling window of size the square root of n near the peaks, each amplitude is asymptotic to an Airy function.

  19. Engagement with HIV prevention treatment and care among female sex workers in Zimbabwe: a respondent driven sampling survey.

    Science.gov (United States)

    Cowan, Frances M; Mtetwa, Sibongile; Davey, Calum; Fearon, Elizabeth; Dirawo, Jeffrey; Wong-Gruenwald, Ramona; Ndikudze, Theresa; Chidiya, Samson; Benedikt, Clemens; Busza, Joanna; Hargreaves, James R

    2013-01-01

    To determine the HIV prevalence and extent of engagement with HIV prevention and care among a representative sample of Zimbabwean sex workers working in Victoria Falls, Hwange and Mutare. Respondent driven sampling (RDS) surveys conducted at each site. Sex workers were recruited using respondent driven sampling with each respondent limited to recruiting 2 peers. Participants completed an interviewer-administered questionnaire and provided a finger prick blood sample for HIV antibody testing. Statistical analysis took account of sampling method. 870 women were recruited from the three sites. HIV prevalence was between 50 and 70%. Around half of those confirmed HIV positive were aware of their HIV status and of those 50-70% reported being enrolled in HIV care programmes. Overall only 25-35% of those with laboratory-confirmed HIV were accessing antiretroviral therapy. Among those reporting they were HIV negative, 21-28% reported having an HIV test in the last 6 months. Of those tested HIV negative, most (65-82%) were unaware of their status. Around two-thirds of sex workers reported consistent condom use with their clients. As in other settings, sex workers reported high rates of gender based violence and police harassment. This survey suggests that prevalence of HIV is high among sex workers in Zimbabwe and that their engagement with prevention, treatment and care is sub-optimal. Intensifying prevention and care interventions for sex workers has the potential to markedly reduce HIV and social risks for sex workers, their clients and the general population in Zimbabwe and elsewhere in the region.

  20. Escherichia coli Population Structure and Antibiotic Resistance at a Buffalo/Cattle Interface in Southern Africa.

    Science.gov (United States)

    Mercat, Mathilde; Clermont, Olivier; Massot, Méril; Ruppe, Etienne; de Garine-Wichatitsky, Michel; Miguel, Eve; Valls Fox, Hugo; Cornelis, Daniel; Andremont, Antoine; Denamur, Erick; Caron, Alexandre

    2015-12-28

    At a human/livestock/wildlife interface, Escherichia coli populations were used to assess the risk of bacterial and antibiotic resistance dissemination between hosts. We used phenotypic and genotypic characterization techniques to describe the structure and the level of antibiotic resistance of E. coli commensal populations and the resistant Enterobacteriaceae carriage of sympatric African buffalo (Syncerus caffer caffer) and cattle populations characterized by their contact patterns in the southern part of Hwange ecosystem in Zimbabwe. Our results (i) confirmed our assumption that buffalo and cattle share similar phylogroup profiles, dominated by B1 (44.5%) and E (29.0%) phylogroups, with some variability in A phylogroup presence (from 1.9 to 12%); (ii) identified a significant gradient of antibiotic resistance from isolated buffalo to buffalo in contact with cattle and cattle populations expressed as the Murray score among Enterobacteriaceae (0.146, 0.258, and 0.340, respectively) and as the presence of tetracycline-, trimethoprim-, and amoxicillin-resistant subdominant E. coli strains (0, 5.7, and 38%, respectively); (iii) evidenced the dissemination of tetracycline, trimethoprim, and amoxicillin resistance genes (tet, dfrA, and blaTEM-1) in 26 isolated subdominant E. coli strains between nearby buffalo and cattle populations, that led us (iv) to hypothesize the role of the human/animal interface in the dissemination of genetic material from human to cattle and toward wildlife. The study of antibiotic resistance dissemination in multihost systems and at anthropized/natural interface is necessary to better understand and mitigate its multiple threats. These results also contribute to attempts aiming at using E. coli as a tool for the identification of pathogen transmission pathway in multihost systems. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  1. A COMPETIÇÃO DO MERCADO, IMPACTO NOS COMPONENTES DO LUCRO CONTÁBIL E NO RETORNO DAS AÇÕES

    Directory of Open Access Journals (Sweden)

    William Brasil Rodrigues Sobrinho

    2014-08-01

    Full Text Available A competição do mercado possui um efeito disciplinador para as firmas, podendo contribuir para melhoria da governança corporativa e redução dos custos de contratos. Em razão do aumento do fluxo das informações e possibilidade de uma maior comparação entre as firmas do mesmo setor, a competição pode limitar a discricionariedade do gestor, inclusive tendo impacto direto na qualidade da informação contábil. Partindo desse pressuposto o presente trabalho investiga a relação existente entre o ambiente competitivo, no qual a firma encontra-se inserida, e a persistência dos lucros e seus componentes (accruals e fluxo de caixa, na obtenção dos lucros e retornos das firmas em períodos seguintes. Foram utilizados como base, o modelo de Dechow (1994, Sloan (1996 e o modelo adaptado de Ali; Hwang; Trombley (2000. Como proxy para a competição foi utilizado o índice de Herfindahl-Hirschman. A amostra contempla as empresas de capital aberto listadas na BM&FBovespa durante o período compreendido entre 2006 e 2012. Os resultados de um modo geral indicam que para a amostra analisada a estrutura de mercado (nível de competição altera a relevância do fluxo de caixa e em setores mais concentrados (menos competitivos os lucros e retornos são superiores.

  2. Mechanisms of herb-induced nephrotoxicity.

    Science.gov (United States)

    Allard, T; Wenner, T; Greten, H J; Efferth, T

    2013-01-01

    Herbal therapies gained much popularity among the general public, but compared to therapies approved by official authorities, toxicological studies are frequently not available for them. Hence, there may be inherent risks and the kidneys may be especially vulnerable to toxic effects. Herbs may induce nephrotoxicity by induction of apoptosis. High oxalate contents in Star fruit (Averrhoa carambola L.) may induce acute nephropathy. Triptolide from Thunder God Vine (Triperygium wilfordii Hook) is a diterpenoid epoxide with induces reactive oxygen species and nephrotubular apoptosis. Cranberry juice is discussed as promoter of kidney stone formation (nephrolithiasis). Abuse of guaifenesin from Roughbark (Guaicum officinale L.) increases stone formation. Aristolochia acids from Aristolochia fangchi Y.C.Wu ex L.D. Chow & S.M. Hwang causes the well-known aristolochic acid nephropathy and carcinogenesis by DNA adduct formation. Carboxyatractyloside from Impila (Callilepsis laureola DC.) inhibits mitochondrial ATP synthesis. Acute allergic interstitial nephritis was diagnosed after intake of Peruvian Cat's claw (Uncaria tomentosa Willd. DC.). Whether or not Willow Bark (Salix alba L.) induces analgesic nephropathwy is a matter of discussion. Other herbal therapies are considered to affect the rennin-angiotensisn-aldosterone (RAA) system Ephedra sinica Stapf with its ingredient ephedrine. Devil's Claw (Harpagophytum procumbens DC. Ex Meisn.) and licorice (Glycyrrhiza glabra L.) may inhibit major renal transport processes needed for filtration, secretion, and absorption. Strategies to minimize nephrotoxicity include (1) quality control and standardization of herbal products, (2) research on the molecular modes of action to better understand pathophysiological mechanisms of herbal products as well as (3) clinical trials to demonstrate efficacy and safety.

  3. Technical and Physical Activities of Small-Sided Games in Young Korean Soccer Players.

    Science.gov (United States)

    Joo, Chang H; Hwang-Bo, Kwan; Jee, Haemi

    2016-08-01

    Joo, CH, Hwang-Bo, K, and Jee, H. Technical and physical activities of small-sided games in young Korean soccer players. J Strength Cond Res 30(8): 2164-2173, 2016-The aim of this study was to examine the technical aspects and physical demands during small-sided games (SSGs) with different sized pitches in young Korean soccer players. Participants were randomly selected during a nationally held youth competition. Three different game formats were used: SSG8 (8 vs. 8 played on a small-sized field [68 × 47 m]), RSG8 (8 vs. 8 played on a regular-sized field [75 × 47 m]), and RSG11 (11 vs. 11 played on a regular-sized field). Eleven technical (ball touches, passes, and shots) and 6 physical demand variables (exercise frequency by intensity) were observed and analyzed. Same variables were also analyzed for the goalkeepers. As a result, SSG8 and RSG8 showed significantly greater numbers of technical plays in 5 and 4 variables in comparison to RSG11, respectively. In addition, although the exercise intensities increased slightly in both SSG formats, the amount was within the similar range as previous reports. In conclusion, the SSGs with reduced number of players may be referred in young players to effectively train them in technical aspects of the game by allowing greater ball exposure time without excessive physical demands. Various confounding factors such as pitch dimension should be carefully considered for training specific technical and physical variables in young Korean players.

  4. Evaluating Dermatology Residency Program Websites.

    Science.gov (United States)

    Ashack, Kurt A; Burton, Kyle A; Soh, Jonathan M; Lanoue, Julien; Boyd, Anne H; Milford, Emily E; Dunnick, Cory; Dellavalle, Robert P

    2016-03-16

    Internet resources play an important role in how medical students access information related to residency programs.Evaluating program websites is necessary in order to provide accurate information for applicants and provide information regarding areas of website improvement for programs. To date, dermatology residency websites (D  WS) have not been evaluated.This paper evaluates dermatology residency websites based on availability of predefined measures. Using the FREIDA (Fellowship and Residency Electronic Interactive Database) Online database, authors searched forall accredited dermatology program websites. Eligible programs were identified through the FREIDA Online database and had a functioning website. Two authors independently extracted data with consensus or third researcher resolution of differences. This data was accessed and archived from July 15th to July 17th, 2015.Primary outcomes measured were presence of content on education, resident and faculty information, program environment, applicant recruitment, schedule, salary, and website quality evaluated using an online tool (WooRank.com). Out of 117 accredited dermatology residencies, 115 had functioning webpages. Of these, 76.5% (75) had direct links found on the FRIEDA Online database. Most programs contained information on education, faculty, program environment, and applicant recruitment. However, website quality and marketing effectiveness were highly variable; most programs were deemed to need improvements in the functioning of their webpages. Also, additional information on current residents and about potential away rotations were lacking from most websites with only 52.2% (60) and 41.7% (48) of programs providing this content, respectively. A majority of dermatology residency websites contained adequate information on many of the factors we evaluated. However, many were lacking in areas that matter to applicants. We hope this report will encourage dermatology residencyprograms

  5. PLGA nanofiber membranes loaded with epigallocatechin-3-O-gallate are beneficial to prevention of postsurgical adhesions

    Directory of Open Access Journals (Sweden)

    Shin YC

    2014-08-01

    Full Text Available Yong Cheol Shin,1,* Won Jun Yang,1,* Jong Ho Lee,1 Jin-Woo Oh,2 Tai Wan Kim,3 Jong-Chul Park,4 Suong-Hyu Hyon,5 Dong-Wook Han1 1Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, Republic of Korea; 2Department of Nanomaterials Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan, Republic of Korea; 3Department of Design, College of Arts, Pusan National University, Busan, Republic of Korea; 4Department of Medical Engineering, Yonsei University College of Medicine, Seoul, Republic of Korea; 5Center for Fiber and Textile Science, Kyoto Institute of Technology, Kyoto, Japan *These authors contributed equally to this work Abstract: This study concentrates on the development of biodegradable nanofiber membranes with controlled drug release to ensure reduced tissue adhesion and accelerated healing. Nanofibers of poly(lactic-co-glycolic acid (PLGA loaded with epigallocatechin-3-O-gallate (EGCG, the most bioactive polyphenolic compound in green tea, were electrospun. The physicochemical and biomechanical properties of EGCG-releasing PLGA (E-PLGA nanofiber membranes were characterized by atomic force microscopy, EGCG release and degradation profiles, and tensile testing. In vitro antioxidant activity and hemocompatibility were evaluated by measuring scavenged reactive oxygen species levels and activated partial thromboplastin time, respectively. In vivo antiadhesion efficacy was examined on the rat peritonea with a surgical incision. The average fiber diameter of E-PLGA membranes was approximately 300–500 nm, which was almost similar to that of pure PLGA equivalents. E-PLGA membranes showed sustained EGCG release mediated by controlled diffusion and PLGA degradation over 28 days. EGCG did not adversely affect the tensile strength of PLGA membranes, whereas it significantly decreased the elastic modulus and increased the strain at break. E-PLGA membranes were significantly effective in

  6. Postoperative pain and patient-controlled epidural analgesia-related adverse effects in young and elderly patients: a retrospective analysis of 2,435 patients

    Directory of Open Access Journals (Sweden)

    Koh JC

    2017-04-01

    Full Text Available Jae Chul Koh, Young Song, So Yeon Kim, Sooyeun Park, Seo Hee Ko, Dong Woo Han Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, South Korea Abstract: In this retrospective study, data of 2,435 patients who received fentanyl and ropivacaine-based patient-controlled epidural analgesia (PCEA for pain relief after elective surgery under general or spinal anesthesia were reviewed. Differences in postoperative pain, incidence of patient-controlled analgesia (PCA-related adverse effects, and risk factors for the need for rescue analgesics for 48 hours postsurgery in young (age 20–39 years and elderly (age ≥70 years patients were evaluated. Although there were no significant differences in postoperative pain intensity between the two groups until 6 hours postsurgery, younger patients experienced greater postoperative pain intensity compared with older patients 6–48 hours postsurgery. While younger patients exhibited greater incidence of numbness, motor weakness, and discontinuation of PCA postsurgery, elderly patients exhibited greater incidence of hypotension, nausea/vomiting, rescue analgesia, and antiemetic administration. Upon multivariate analysis, low fentanyl dosage and history of smoking were found to be associated with an increased need for rescue analgesia among younger patients, while physical status classification III/IV and thoracic surgery were associated with a decreased need for rescue analgesia among the elderly. Discontinuation of PCA was more frequent among younger patients than the elderly (18.5% vs 13.5%, P=0.001. Reasons for discontinuation of PCA among young and elderly patients, respectively, were nausea and vomiting (6.8% vs 26.6%, numbness or motor weakness (67.8% vs 11.5%, urinary retention (7.4% vs 8.7%, dizziness (2.2% vs 5.2%, and hypotension (3.1% vs 20.3%. In conclusion, PCEA was more frequently associated with numbness, motor

  7. Effectiveness of elastic band-type ankle–foot orthoses on postural control in poststroke elderly patients as determined using combined measurement of the stability index and body weight-bearing ratio

    Directory of Open Access Journals (Sweden)

    Kim JH

    2015-11-01

    Full Text Available Jong Hyun Kim, Woo Sang Sim, Byeong Hee Won Usability Evaluation Technology Center, Advanced Biomedical and Welfare R&D Group, Korea Institute of Industrial Technology, Cheonan-si, Chungcheongnam-do, South Korea Purpose: Poor recovery of postural stability poststroke is the primary cause of impairment in activities and social participation in elderly stroke survivors. The purpose of our study was to experimentally evaluate the effectiveness of our new elastic ankle–foot orthosis (AFO, compared to a traditional AFO fabricated with hard plastic, in improving postural stability in elderly chronic stroke survivors. Patients and methods: Postural stability was evaluated in ten chronic stroke patients, 55.7±8.43 years old. Postural stability was evaluated using the standardized methods of the Biodex Balance System combined with a foot pressure system, under three experimental conditions, no AFO, rigid plastic AFO, and elastic AFO (E-AFO. The following dependent variables of postural stability were analyzed: plantar pressure under the paretic and nonparetic foot, area of the center of balance (COB and % time spent in each location, distance traveled by the COB away from the body center, distance traveled by the center of pressure, and calculated index of overall stability, as well as indices anterior–posterior and medial–lateral stability. Results: Both AFO designs improved all indices of postural stability. Compared to the rigid plastic AFO, the E-AFO produced additional positive effects in controlling anterior–posterior body sway, equalizing weight bearing through the paretic and nonparetic limbs, and restraining the displacement of the center of pressure and of the COB. Conclusion: Based on our outcomes, we recommend the prescription of E-AFOs as part of a physiotherapy rehabilitation program to promote recovery of postural stability poststroke. When possible, therapeutic outcomes should be documented using the Biodex Balance System and

  8. Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation

    Directory of Open Access Journals (Sweden)

    Yoon TH

    2012-03-01

    Full Text Available Ki-Chun Yoo1, Chang-Hwan Yoon1, Dongwook Kwon2, Kyung-Hwan Hyun1, Soo Jung Woo1, Rae-Kwon Kim1, Eun-Jung Lim1, Yongjoon Suh1, Min-Jung Kim1, Tae Hyun Yoon2, Su-Jae Lee11Laboratory of Molecular Biochemistry, 2Laboratory of Nanoscale Characterization and Environmental Chemistry, Department of Chemistry, Hanyang University, Seoul, Republic of KoreaBackground: Titanium dioxide (TiO2 has been widely used in many areas, including biomedicine, cosmetics, and environmental engineering. Recently, it has become evident that some TiO2 particles have a considerable cytotoxic effect in normal human cells. However, the molecular basis for the cytotoxicity of TiO2 has yet to be defined.Methods and results: In this study, we demonstrated that combined treatment with TiO2 nanoparticles sized less than 100 nm and ultraviolet A irradiation induces apoptotic cell death through reactive oxygen species-dependent upregulation of Fas and conformational activation of Bax in normal human cells. Treatment with P25 TiO2 nanoparticles with a hydrodynamic size distribution centered around 70 nm (TiO2P25–70 together with ultraviolet A irradiation-induced caspase-dependent apoptotic cell death, accompanied by transcriptional upregulation of the death receptor, Fas, and conformational activation of Bax. In line with these results, knockdown of either Fas or Bax with specific siRNA significantly inhibited TiO2-induced apoptotic cell death. Moreover, inhibition of reactive oxygen species with an antioxidant, N-acetyl-L-cysteine, clearly suppressed upregulation of Fas, conformational activation of Bax, and subsequent apoptotic cell death in response to combination treatment using TiO2P25–70 and ultraviolet A irradiation.Conclusion: These results indicate that sub-100 nm sized TiO2 treatment under ultraviolet A irradiation induces apoptotic cell death through reactive oxygen species-mediated upregulation of the death receptor, Fas, and activation of the preapoptotic protein

  9. Agricultural Fragility Estimates Subjected to Volcanic Ash Fall Hazards

    Science.gov (United States)

    Ham, H. J.; Lee, S.; Choi, S. H.; Yun, W. S.

    2015-12-01

    Agricultural Fragility Estimates Subjected to Volcanic Ash Fall Hazards Hee Jung Ham1, Seung-Hun Choi1, Woo-Seok Yun1, Sungsu Lee2 1Department of Architectural Engineering, Kangwon National University, Korea 2Division of Civil Engineering, Chungbuk National University, Korea ABSTRACT In this study, fragility functions are developed to estimate expected volcanic ash damages of the agricultural sector in Korea. The fragility functions are derived from two approaches: 1) empirical approach based on field observations of impacts to agriculture from the 2006 eruption of Merapi volcano in Indonesia and 2) the FOSM (first-order second-moment) analytical approach based on distribution and thickness of volcanic ash observed from the 1980 eruption of Mt. Saint Helens and agricultural facility specifications in Korea. Fragility function to each agricultural commodity class is presented by a cumulative distribution function of the generalized extreme value distribution. Different functions are developed to estimate production losses from outdoor and greenhouse farming. Seasonal climate influences vulnerability of each agricultural crop and is found to be a crucial component in determining fragility of agricultural commodities to an ash fall. In the study, the seasonality coefficient is established as a multiplier of fragility function to consider the seasonal vulnerability. Yields of the different agricultural commodities are obtained from Korean Statistical Information Service to create a baseline for future agricultural volcanic loss estimation. Numerically simulated examples of scenario ash fall events at Mt. Baekdu volcano are utilized to illustrate the application of the developed fragility functions. Acknowledgements This research was supported by a grant 'Development of Advanced Volcanic Disaster Response System considering Potential Volcanic Risk around Korea' [MPSS-NH-2015-81] from the Natural Hazard Mitigation Research Group, Ministry of Public Safety and Security of

  10. A Chinese Chan-based mind–body intervention improves psychological well-being and physical health of community-dwelling elderly: a pilot study

    Directory of Open Access Journals (Sweden)

    Yu R

    2014-04-01

    Full Text Available Ruby Yu,1 Jean Woo,1 Agnes S Chan,2–4 Sophia L Sze2,3 1Department of Medicine and Therapeutics, 2Department of Psychology, 3Chanwuyi Research Center for Neuropsychological Well-Being, The Chinese University of Hong Kong, New Territories, Hong Kong; 4Henan Songshan Research Institute for Chanwuyi, Henan, People's Republic of China Background: The aim of this study was to explore the potential benefits of the Dejian mind–body intervention (DMBI for psychological and physical health in older Chinese adults. Methods: After confirmation of eligibility, the subjects were invited to receive DMBI once a week for 12 weeks. The intervention involved components of learning self-awareness and self-control, practicing mind–body exercises, and adopting a special vegetarian diet. Intervention-related changes were measured using the Perceived Stress Scale, Geriatric Depression Scale, Pittsburgh Sleep Quality Index, Chinese Constipation Questionnaire, and self-report ratings of health. Indicators of metabolic syndrome and walking speed were also measured. Results: Of the 44 subjects recruited, 42 (54.8% men completed the study, giving an adherence rate of 95%. There was a significant reduction in perceived stress (P<0.05. A significant improvement was also found in systolic blood pressure among those who had abnormally high blood pressure at baseline (P<0.05. Physical fitness as reflected by walking speed was also significantly increased after the intervention (P<0.05. Sleep disturbances were reduced (P<0.01. Self-rated health was significantly enhanced, with the percentage rating very good health increasing from 14.3% at baseline to 42.8% after the intervention (P<0.001. No intervention effect was found for waist circumference, lipids and fasting blood glucose levels, Pittsburgh Sleep Quality Index global score, and constipation measures. Conclusion: The DMBI was feasible and acceptable, and subjects showed some improvements in psychological and physical

  11. The effect of dietary antioxidant on the COPD risk: the community-based KoGES (Ansan–Anseong cohort

    Directory of Open Access Journals (Sweden)

    Joshi P

    2015-10-01

    Full Text Available Pankaj Joshi,1,2 Woo Jin Kim,3,4 Sang-Ah Lee1–3 1Department of Preventive Medicine, 2BIT Medical Convergence Graduate Program, 3Department of Internal Medicine, 4Environmental Health Center, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea Background: Dietary antioxidants have been suggested to have protective role against chronic obstructive pulmonary disease (COPD, but few prospective studies examined this relationship. The prospective study was conducted to evaluate the effect of dietary antioxidants on COPD risk and lung function in the Korean population.Methods: The data were collected from the community-based Korean Genome Epidemiology Study (KoGES cohort. To diagnose COPD, forced expiratory volume (FEV1 and forced vital capacity (FVC were measured by spirometry. The dietary intake of antioxidant vitamins was estimated from validated Food-Frequency Questionnaire. For the analysis, 325 COPD patients and 6,781 at risk subjects were selected from the cohort of 10,038 subjects. Multiple logistic regression models were used to examine the odds ratio (OR after adjusting for age, sex, marital status, income, history of asthma, history of tuberculosis, and smoking.Results: The risk of COPD was positively associated with aging, low education, low household income, lower body mass index, and cigarette smoking. The risk of COPD decreased with increase in the dietary vitamin C (ORQ1 vs Q5=0.66, Ptrend=0.03 and vitamin E (ORQ1 vs Q5=0.56, Ptrend=0.05 intake, predominantly, in men (Ptrend=0.01 and 0.05 for vitamins C and E, respectively. In addition, the lung function was significantly improved with increase in vitamins C (FEV1, P=0.04; FVC, P=0.03 and E (FEV1, P=0.03; FVC, P=0.04 intake. No statistically significant interactions were observed between smoking and vitamin C or E intake in relation to COPD risk among men.Conclusion: Our results suggest the independent beneficial effect of antioxidants, particularly

  12. Effect of Recruitment Methods on Response Rate in a Web-Based Study for Primary Care Physicians: Factorial Randomized Controlled Trial.

    Science.gov (United States)

    So, Ryuhei; Shinohara, Kiyomi; Aoki, Takuya; Tsujimoto, Yasushi; Suganuma, Aya M; Furukawa, Toshi A

    2018-02-08

    Medical Information Network Clinical Trials Registry UMIN000025317; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000029121 (Archived by WebCite at http://www.webcitation. org/6wOo1jl9t). ©Ryuhei So, Kiyomi Shinohara, Takuya Aoki, Yasushi Tsujimoto, Aya M Suganuma, Toshi A Furukawa. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 08.02.2018.

  13. Highlights of Astronomy, Vol. 15

    Science.gov (United States)

    Corbett, Ian

    2010-11-01

    Preface; Part I. Gruber Cosmology Prize Lecture; Part II. Invited Discourses; Part III. Joint Discussions: 1. Dark matter in early-type galaxies Léon V. E. Koopmans and Tommaso Treu; 2. Diffuse light in galaxy clusters Magda Arnaboldi and Ortwin Gerhard; 3. Neutron stars - timing in extreme environments Tomaso Belloni, Mariano Méndez and Chengmin Zhang; 4. Progress in understanding the physics of Ap and related stars Margarida Cunha; 5. Modelling the Milky Way in the age of Gaia Annie C. Robin; 6. Time and astronomy Pascale Defraigne; 7. Astrophysical outflows and associated accretion phenomena Elisabete M. de Gouveia Dal Pino and Alex C. Raga; 8. Hot interstellar matter in elliptical galaxies Dong-Woo Kim and Silvia Pellegrini; 9. Are the fundamental constants varying with time? Paolo Molaro and Elisabeth Vangioni; 10. 3D views on cool stellar atmospheres - theory meets observation K. N. Nagendra, P. Bonifacio and H. G. Ludwig; 11. New advances in helio- and astero-seismology; 12. The first galaxies - theoretical predictions and observational clues; 13. Eta Carinae in the context of the most massive stars Theodore R. Gull and Augusto Damineli; 14. The ISM of galaxies in the far-infrared and sub-millimetre; 15. Magnetic fields in diffuse media Elisabete M. de Gouveia Dal Pino and Alex Lazarian; 16. IHY global campaign - whole heliosphere interval; Part IV. Special Sessions: SpS 1. IR and sub-mm spectroscopy - a new tool for studying stellar evolution Glenn Wahlgren, Hans Käufl and Florian Kerber; SpS 2. The international year of astronomy Pedro Russo, Catherine Cesarsky and Lars Lindberg Christensen; SpS 3. Astronomy in Antarctica in 2009 Michael G. Burton; SpS 4. Astronomy education between past and future J. P. De Greve; SpS 5. Accelerating the rate of astronomical discovery Ray P. Norris; SpS 6. Planetary systems as potential sites for life Régis Courtin, Alan Boss and Michel Mayor; SpS 7. Young stars, brown dwarfs, and protoplanetary disks Jane Gregorio

  14. Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD

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    Kim SW

    2015-09-01

    Full Text Available Sei Won Kim,1 Jong Min Lee,1 Jick Hwan Ha,1 Hyeon Hui Kang,1 Chin Kook Rhee,1 Jin Woo Kim,1 Hwa Sik Moon,1 Ki Hyun Baek,2 Sang Haak Lee1 1Division of Pulmonology, Critical Care and Sleep Medicine, 2Division of Endocrinology and Metabolism, Department of Internal Medicine, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Background: Patients with COPD are at an increased risk of osteoporosis. Although many studies have addressed the relationship between the vitamin D receptor (VDR polymorphisms and bone health, this relationship has not been fully investigated in patients with COPD. In this study, we investigated the association of VDR polymorphisms with bone mineral density (BMD and other clinical parameters in patients with COPD. Patients and methods: In total, 200 patients with COPD were included in this study. The VDR polymorphisms rs1544410 (A/G-BsmI, rs7975232 (A/C-ApaI, rs731236 (C/T-TaqI, and rs10735810 (C/T-FokI were determined by Sanger sequencing using blood DNA samples. BMD of the lumbar vertebra and the femoral neck was measured by dual-energy X-ray absorptiometry. Other clinical parameters were also evaluated. Haplotype and multivariate analyses were also performed. Results: Sex, body mass index, steroid use, percentage of forced expiratory volume in 1 second (FEV1, alkaline phosphatase, and 25-hydroxyvitamin D significantly influenced the risk of osteoporosis. Patients with osteoporosis were more likely to carry the rs7975232 C allele compared to normal patients with BMD. Haplotypes GCT and GAT were related to osteoporosis. Patients without the haplotype GAT allele showed a significantly lower T-score at the femoral neck and an increased risk of osteoporosis (odds ratio [OR]= 2.78, 95% confidence interval [CI]= 1.20–6.48, P=0.018 compared with carriers in the dominant model. Conclusion: Genetic variations in VDR are significantly associated with osteoporosis among patients with COPD

  15. EFFECT OF THE FILL VENTILATION WINDOW ON PERFORMANCE OF A NATURAL DRAFT COOLING TOWER SUBJECTED TO CROSS-WINDS

    Directory of Open Access Journals (Sweden)

    K. V. Dobrego

    2016-01-01

    Full Text Available Various aerodynamic design elements and technics (wind deflectors, wind walls, etc. are utilized for improvement of the thermal efficiency of the natural draft cooling towers, particularly in conditions of cross wind. One of the technical methods, proposed by engineers of Belarus Academy of Sciences, is installation of the ventilation window in the center of the fill. This method is substantiated by the fact that the flow of cooling gas obtains maximum temperature and humidity near the center of the under-fill space of cooling tower and, as a consequence, performs minimal heat exchange. The influence of the fill ventilation window and wind deflectors in the inlet windows of the cooling tower on its thermal performance in condition of cross-wind is investigated in the paper numerically. The cooling tower of the “Woo-Jin” power plant (China 150 m of the height and 114 m of the base diameter was taken as a prototype. The analogy (equivalence between the heat and mass transfer was taken into consideration, which enabled us to consider single-phase flow and perform complicated 3D simulation by using modern personal computers. Heat transfer coefficient for the fill and its hydrodynamic resistance were defined by using actual data on total flow rate in the cooling tower. The numerical model and computational methods were tested and verified in numerous previous works. The non-linear dependence of the thermal performance of the cooling tower on wind velocity (with the minimum in vicinity of Ucr ~ 8 m/s for the simulated system was demonstrated. Calculations show that in the condition of the average wind speed the fill ventilation window doesn’t improve, but slightly decrease (by 3–7 % performance of the cooling tower. Situation changes in the condition of strong winds Ucw > 12 m/s, which are not typical for Belarus. Utilization of airflow deflectors at the inlet windows of cooling tower, conversely, increases thermal performance of the

  16. Proteinaceous Resin and Hydrophilic Encapsulation: A Self-Healing-Related Study

    Science.gov (United States)

    Zheng, Ting

    .g. hydrophilic agent encapsulation, was addressed through the development of novel polyurethane-Poly(melamine-formaldehyde) (PU-PMF) dual-component capsules. Remarkably, the external PU insulation layer was fabricated through interfacial polymerization based on a water-in-oil-in-oil (W/O/O) emulsion template. Surface tension was identified as the main driving factor for the formation of the external oil phase. The internal PMF layer was observed to strongly influence the internal morphology of the capsule. A protocol was developed, and a typical capsule with dense and neat shell morphology with a shell/capsule diameter (around 3 %) was fabricated. This study provides solutions for the two aforementioned obstacles related to the development of the healing system for the protein-based materials.

  17. Presence of sarcopenia in asthma–COPD overlap syndrome may be a risk factor for decreased bone-mineral density, unlike asthma: Korean National Health and Nutrition Examination Survey (KNHANES IV and V (2008–2011

    Directory of Open Access Journals (Sweden)

    Lee DW

    2017-08-01

    Full Text Available Dong-Won Lee,1 Hyun-Jung Jin,2 Kyeong-Cheol Shin,2 Jin-Hong Chung,2 Hyoung-Woo Lee,3 Kwan-Ho Lee2 1Division of Pulmonology, Department of Internal Medicine, Andong Sungso Hospital, Andong, 2Division of Pulmonology and Allergy, 3Division of Endocrinology, Department of Internal Medicine, Yeungnam University Hospital, Daegu, South Korea Background: Sarcopenia and decreased bone-mineral density (BMD are common in elderly people, and are major comorbidities of obstructive airway disease (OAD. However, the relationship between sarcopenia and BMD in each OAD phenotype, especially asthma–COPD overlap syndrome (ACOS, is not yet clear. We aimed to evaluate differences in BMD according to the presence of sarcopenia in each OAD phenotype. Materials and methods: Among the research subjects in KNHANES IV and V (2008–2011, 5,562 were ≥50 years old and underwent qualified spirometry and dual-energy X-ray absorptiometry. A total of 947 subjects were included in the study: 89 had asthma, 748 COPD, and 110 ACOS. Results: In the COPD and ACOS phenotypes, T-scores were lower in the sarcopenia group than the nonsarcopenia group. Prevalence rates of osteopenia and osteoporosis were higher in the sarcopenia group than the nonsarcopenia group. (P<0.001 and P=0.017, respectively. The sarcopenia group had higher risks of developing osteopenia, osteoporosis, and low BMD than the nonsarcopenia group in the ACOS phenotype (OR 6.620, 95% CI 1.129–38.828 [P=0.036], OR 9.611, 95% CI 1.133–81.544 [P=0.038], and OR 6.935, 95% CI 1.194–40.272 [P=0.031], respectively. However, in the asthma phenotype, the sarcopenia group showed no increased risk compared with the nonsarcopenia group. Conclusion: In the ACOS phenotype, individuals with sarcopenia had a higher prevalence rate and higher risks of osteopenia and osteoporosis than those without sarcopenia among all OAD phenotypes. Keywords: asthma, chronic obstructive pulmonary disease, asthma–COPD overlap syndrome

  18. RETRACTED: The Mediating Effect of Social Capital on the Relationship Between Public Health Managers' Transformational Leadership and Public Health Nurses' Organizational Empowerment in Korea Public Health

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    Soo Young Jun, MPH, RN

    2017-12-01

    Full Text Available This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal.The Editor-in-Chief and ANR editorial board have decided to retract this article because the scientific integrity of the content cannot be guaranteed. The article shows evidence of redundant publication and falsification of instruments.This article was a duplicate of a paper that had already been published in Journal of the Korean Data & Information Science Society Vol 29, No. 3, May 2017. doi 10.7465/jkdi.2017.28.3.585 The identical data collection period, study sample, variables, and instruments between these two papers show strong evidence of plagiarism. One of the conditions of submission of a paper for publication is that authors declare explicitly that their work is original and has not appeared in a publication elsewhere. Re-use of any data should be appropriately cited.This article is published based on a master’s thesis (Kim YE. The effects of the transformational leadership of managers perceived by public health nurses and their social capital on empowerment [master’s thesis]. Dague (Korea: Kyungpook National University; 2016. p. 1-57. and the author of this dissertation is deleted. Inappropriate use of master’s thesis without appropriate disclosure and/or citation was made.The instruments [Multifactor leadership questionnaire (Kim DW. The relationship between transformational leadership and quality of nurses' care Service with nurses' organization citizenship behavior as a moderator. Health Soc Welf Rev. 2011;31(2:206e36. Korean, social capital (Han JW, Woo HY, Ju ES, Lim SH, Han SS. Effects of nurses' social capital on turnover intention: focused on the mediating effects organizational commitment and organizational cynicism. J Korean Acad Nurs. 2013;43(4:517e25. https://doi.org/10.4040/jkan.2013.43.4.517. Korean, and Organizational empowerment (Oh EH, Chung BY. The effect of

  19. Analysis of Factors Controlling Cell Cycle that Can Be Synchronized Nondestructively During Root Cap Development

    Energy Technology Data Exchange (ETDEWEB)

    Hawes, Martha

    2011-02-04

    Publications and presentations during the final funding period, including progress in defining the substrate specificity, the primary goal of the project, are listed below. Both short-term and long-term responses mediated by PsUGT1 have been characterized in transgenic or mutant pea, alfalfa, and Arabidopsis with altered expression of PsUGT1. Additional progress includes evaluation of the relationship between control of the cell cycle by PsUGT1 and other glycosyltransferase and glycosidase enzymes that are co-regulated in the legume root cap during the onset of mitosis and differentiation. Transcriptional profiling and multidimensional protein identification technology ('MudPIT') have been used to establish the broader molecular context for the mechanism by which PsUGT1 controls cell cycle in response to environmental signals. A collaborative study with the Norwegian Forest Research Institute (who provided $10,000.00 in supplies and travel funds for collaborator Dr. Toril Eldhuset to travel to Arizona and Dr. H. H. Woo to travel to Norway) made it possible to establish that the inducible root cap system for studying carbohydrate synthesis and solubilization is expressed in gymnosperm as well as angiosperm species. This discovery provides an important tool to amplify the potential applications of the research in defining conserved cell cycle machinery across a very broad range of plant species and habitats. The final work, published during 2009, revealed an additional surprising parallel with mammalian immune responses: The cells whose production is controlled by PsUGT1 appear to function in a manner which is analogous to that of white blood cells, by trapping and killing in an extracellular manner. This may explain why mutation within the coding region of PsUGT1 and its homolog in humans (UGT1) is lethal to plants and animals. The work has been the subject of invited reviews. A postdoctoral fellow, eight undergraduate students, four M.S. students and

  20. Nuclear employers meeting their employees' motives

    International Nuclear Information System (INIS)

    Heininen-Ojanperae, Marke

    1998-01-01

    Full text: In modem Western societies the employees' motivational issues are no more only their employers' concern. The pioneering, older generations in the nuclear field may share a sense of common depression. The 'emulator' generation with to 15 years of work experience may find they cannot see clear or similar career paths due to construction recession. Their skills may be harnessed in future decommissioning, only. Finally, the young people entering professional education with these signs around may opt for other competing trades already during their first years in college and university, although their capacity would be crucial in case of any new wave arising. However, nuclear generation is a trade as any, even the safety concern can be seen as a facet of quality of the nuclear companies' service, which can be drawn in any situation from the customers or stake holders. All businesses have life-cycles and only a few of us can ride the rising wave - the majority of us are either lagging behind or too early. This is not to deny the general responsibility of those wooing new people to the trade or having made earlier decisions. The motivational solution, if any, is to be found in celebrating the richness of the individual and local working situations. With this idea in mind, we may summarise a set of constructive approaches for motivation: - The complexity of the work and technical condition at nuclear plants; - Certain exclusiveness of the work; - Heritage of good working conditions and quality philosophy; - Large risks that can actually be managed at everyday work; - Certain general environmental benefits; - Heritage of global aspects in networking; - The promise and new learning of new user-countries; - Scientific emphasis; - Waning Big Science approach; - Many nuclear plants are situated in impressive settings of nature. Finally, there is also a set of de-constructive, motivational factors: - The quest of high, total availability as basic load power excludes a

  1. Biological age as a health index for mortality and major age-related disease incidence in Koreans: National Health Insurance Service – Health screening 11-year follow-up study

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    Kang YG

    2018-03-01

    Full Text Available Young Gon Kang,1 Eunkyung Suh,2 Jae-woo Lee,3 Dong Wook Kim,4 Kyung Hee Cho,5 Chul-Young Bae1 1Department of R&D, MediAge Research Center, Seongnam, Republic of South Korea; 2Department of Family Medicine, College of Medicine, CHA University, Chaum, Seoul, Republic of South Korea; 3Department of Family Medicine, College of Medicine, Chungbuk National University, Cheongju, Republic of South Korea; 4Department of Policy Research Affairs, National Health Insurance Service Ilsan Hospital, Goyang, Republic of South Korea; 5Department of Family Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Republic of South KoreaPurpose: A comprehensive health index is needed to measure an individual’s overall health and aging status and predict the risk of death and age-related disease incidence, and evaluate the effect of a health management program. The purpose of this study is to demonstrate the validity of estimated biological age (BA in relation to all-cause mortality and age-related disease incidence based on National Sample Cohort database.Patients and methods: This study was based on National Sample Cohort database of the National Health Insurance Service – Eligibility database and the National Health Insurance Service – Medical and Health Examination database of the year 2002 through 2013. BA model was developed based on the National Health Insurance Service – National Sample Cohort (NHIS – NSC database and Cox proportional hazard analysis was done for mortality and major age-related disease incidence.Results: For every 1 year increase of the calculated BA and chronological age difference, the hazard ratio for mortality significantly increased by 1.6% (1.5% in men and 2.0% in women and also for hypertension, diabetes mellitus, heart disease, stroke, and cancer incidence by 2.5%, 4.2%, 1.3%, 1.6%, and 0.4%, respectively (p<0.001.Conclusion: Estimated BA by the developed BA model based on NHIS – NSC database is expected to be

  2. More efficient evolutionary strategies for model calibration with watershed model for demonstration

    Science.gov (United States)

    Baggett, J. S.; Skahill, B. E.

    2008-12-01

    distribution algorithms. pp. 75-102, Springer Kern, S., N. Hansen and P. Koumoutsakos (2006). Local Meta-Models for Optimization Using Evolution Strategies. In Ninth International Conference on Parallel Problem Solving from Nature PPSN IX, Proceedings, pp.939-948, Berlin: Springer. Tahk, M., Woo, H., and Park. M, (2007). A hybrid optimization of evolutionary and gradient search. Engineering Optimization, (39), 87-104.

  3. Risk factors for chronic obstructive pulmonary disease among never-smokers in Korea

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    Lee SJ

    2015-03-01

    Full Text Available Seok Jeong Lee,1 Seo Woo Kim,1 Kyoung Ae Kong,2 Yon Ju Ryu,1 Jin Hwa Lee,1 Jung Hyun Chang1 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 2Department of Clinical Trial Center, School of Medicine, Ewha Womans University, Seoul, Republic of Korea Background: Chronic obstructive pulmonary disease (COPD patients include those who have never smoked. However, risk factors other than smoking in never-smokers have not been elucidated sufficiently. This study investigated the risk factors for COPD among never-smokers in Korea using population-based data. Methods: The data were retrieved from the Korean National Health and Nutrition Survey IV conducted from 2007 to 2009. Among subjects aged 40 years or older who underwent appropriate pulmonary function tests, never-smokers not diagnosed with asthma and not showing a restrictive pattern on pulmonary function tests were enrolled. Risk factors of COPD in never-smokers were analyzed using logistic regression models. Results: Among 24,871 participants in the representative Korean cohort, 3,473 never-smokers were enrolled. COPD patients accounted for 7.6% of the never-smokers. In the logistic regression analysis, low education status (odds ratio [OR]: 2.0; 95% confidence interval [CI]: 1.2–3.2, occupational exposure (OR: 2.6; 95% CI: 1.3–5.3, a history of tuberculosis (OR: 4.5; 95% CI: 2.3–8.7, bronchiectasis (OR: 6.0; 95% CI: 1.4–25.4, male sex (OR: 4.2; 95% CI: 2.6–6.7, advanced age (60–69 years vs 40–49 years; OR: 3.8; 95% CI: 2.0–7.0, and being underweight (body mass index <18.5 vs 18.0–24.9 kg/m2; OR: 3.1; 95% CI: 1.0–9.4 were associated with the development of COPD. Conclusion: Low education status, manual labor, a history of tuberculosis and bronchiectasis, as well as male sex, advanced age and being underweight were risk factors for COPD in Korean never-smokers. Keywords: socioeconomic status, chronic obstructive pulmonary disease, never-smoker

  4. Testing geopressured geothermal reservoirs in existing wells: Detailed completion prognosis for geopressured-geothermal well of opportunity, prospect #7

    Energy Technology Data Exchange (ETDEWEB)

    Godchaux, Frank A.

    1981-06-01

    This book is a detailed prognosis covering the acquisition, completion, drilling, testing and abandonment of the Frank A. Godchaux, III, Well No. 1 under the Wells of Opportunity Program. The well is located approximately 12 miles southeast of the city of Abbeville, Louisiana. Eaton Operating Company proposes to test a section of the Planulina sand at a depth ranging from 15,584 to 15,692 feet. The reservoir pressure is estimated to be 14,480 psi and the temperature of the formation water is expected to be 298 F. The water salinity is calculated to be 75,000 ppm. The well is expected to produce 20,000 barrels of water per day with a gas content of 44 standard cubic feet pre barrel. The well was acquired from C and K Petroleu, Inc. on March 20, 1981. C and K abandoned the well at a total depth of 16,000 feet. The well has a 7-5/8 inches liner set at 13,387 feet. Eaton proposes to set 5-1/2 inch casing at 16,000 feet and produce the well through the casing using a 2-3/8 inch tubing string for wireline protection and for pressure control. A 4,600 foot saltwater disposal well will be drilled on the site and testing will be conducted similar to previous Eaton tests. The total estimated cost to perform the work is $2,959,000. An optional test from 14,905 to 15,006 feet may be performed after the original test and will require a workover with a rig on location to perform the plugback. The surface production equipment utilized on previous Eaton WOO tests will be utilized on this test. This equipment has worked satisfactorily and all parties involved in the testing are familiar with its operation. The Institute of Gas Technology and Mr. Don Clark will handle the sampling and testing and reservoir evaluation, respectively, as on the previous Eaton tests.

  5. Comorbidities in obstructive lung disease in Korea: data from the fourth and fifth Korean National Health and Nutrition Examination Survey

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    Park HJ

    2015-08-01

    Full Text Available Hee Jin Park, Ah Young Leem, Sang Hoon Lee, Ju Han Song, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Kyung Soo Chung Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Institute of Chest Disease, Yonsei University College of Medicine, Seoul, South Korea Background: Comorbidities can occur frequently in patients with chronic obstructive pulmonary disease (COPD and can influence mortality and morbidity independently. It is increasingly recognized that many patients with COPD have comorbidities that have a major impact on their quality of life and survival. Therefore, we investigated the prevalence of comorbidities in Korean COPD populations. Methods: We used data obtained in the 6 years of the fourth and fifth Korean National Health and Nutrition Examination Survey (KNHANES IV and V. Among 50,405 subjects, 16,151 subjects aged ≥40 years who performed spirometry adequately were included in this study. Airway obstruction was defined as forced expiratory volume in 1 second/forced vital capacity <0.7, and the Global Initiative For Chronic Obstructive Lung Disease stage was used to evaluate the severity of airway obstruction. Statistical analyses were performed using SAS 9.2. Results: Among the 16,151 subjects (43.2% male, 56.8% female; mean age: 57.1 years for men and 57.2 years for women, 13.1% had obstructive lung function; 11.3%, restrictive lung function; and 75.6%, normal lung function. Among individuals with obstructive lung function, 45.3%, 49.4%, and 5.3% had mild, moderate, and severe and very severe airflow limitation. The prevalence of hypertension, diabetes mellitus (DM, underweight, and hypertriglyceridemia was higher in the obstructive lung function group than in the normal lung function group (49.6% vs 35.2%; 16.8% vs 10.5%; 3.3% vs 1.3%; 19.7% vs 17.0%. According to the severity of airway obstruction, hypertension and underweight were more common as severity increased

  6. Cut-off value of FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction in a Korean population

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    Chung KS

    2016-08-01

    Full Text Available Kyung Soo Chung,1,2 Ji Ye Jung,1,2 Moo Suk Park,1,2 Young Sam Kim,1,2 Se Kyu Kim,1,2 Joon Chang,1,2 Joo Han Song1,2 1Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; 2Institute of Chest Disease, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea Background: Forced expiratory volume in 1 second (FEV1/forced expiratory volume in 6 seconds (FEV6 has been proposed as an alternative to FEV1/forced vital capacity (FVC for detecting airway obstruction. A fixed cut-off value for FEV1/FEV6 in a Korean population is lacking. We investigated a fixed cut-off for FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction.Materials and methods: We used data obtained in the 5 years of the Fifth and Sixth Korean National Health and Nutrition Examination Survey. A total of 14,978 participants aged ≥40 years who underwent spirometry adequately were the study cohort. “Airway obstruction” was a fixed cut-off FEV1/FVC <70% according to the Global Initiative for Chronic Obstructive Lung Disease guidelines. We also used European Respiratory Society/Global Lung Initiative 2012 equations for the FEV1/FVC lower limit of normal.Results: Among the 14,978 participants (43.5% male, 56.5% female; mean age: 56.9 years for men and 57.0 years for women, 14.0% had obstructive lung function according to a fixed cut-off FEV1/FVC <70%. Optimal FEV1/FEV6 cut-off for predicting FEV1/FVC <70% was 75% using receiver operating characteristic curve analyses (area under receiver operating characteristic curve =0.989, 95% confidence interval 0.987–0.990. This fixed cut-off of FEV1/FEV6 showed 93.8% sensitivity, 94.8% specificity, 74.7% positive predictive value, 98.9% negative predictive value, and 0.8 Cohen’s kappa coefficient. When compared with FEV1/FVC < lower limit of normal, FEV1/FEV6 <75% tended to over-diagnose airflow limitation (just like a fixed cut

  7. [Dentistry in Korean during the Japanese occupation].

    Science.gov (United States)

    Shin, Jae-Eu

    2004-12-01

    The Japanese introduction of dentistry into Korea was for treating the Japanese residing in Korea Noda-Oji was the first Japanese dentist for Japanese people in Korea in 1893, and Narajaki doyoyo, an invited dentist was posted in the Korean headquarter of Japanese army in September, 1905. The imperialist Japan licensed the dental technicians (yipchisa) without limit and controlled them generously so they could practice dentistry freely. This measure was contrary to that in Japan. (In Japan no new dental technician was licensed.) Komori, a dental technician opened his laboratory at Chungmuro in 1902. The dental technician had outnumbered by 1920. In 1907, the first Korean dental technician Sung-Ryong Choi practiced dentistry in Jongno. The imperialist Japan made the regulations for dental technicians to set a limit to the advertisement and medical practice of dental technicians. The first Korean dentists Suk-Tae Ham was register No. 1 in the dentist license. The Kyungsung dental school was established by Nagira Dasoni for the purpose of educating some Korean people that contributed to Japanese colonization. It made progress with the help of Japan, it was was given the approval of the establishment of the professional school in January the 25th, 1929. It was intended to produce Korean dentists in the first place but became the school for Japanese students later on. The association of Chosun dentist, which had been founded by Narajaki doyoyo, was managed by Japanese dentists in favor of the colonial ruling. The Hansung Association of Dentists established in 1925 was the organization made by the necessity of the association for Koreans only. The Japanese forcefully annexed the Association of Hansung Dentists (Koreans only) to the Association of Kyungsung Dentists to avoid collective actions of Korean dentists in the name of 'Naesunilche' -- 'Japan and Korea and one'. Their invading intention was shown in the event of 'decayed tooth preventive day'. Japanese controlled

  8. Dentistry in Korea during the Japanese Occupation

    Directory of Open Access Journals (Sweden)

    SHIN Jae-Eu

    2004-12-01

    Full Text Available The Japanese introduction of dentistry into Korea was for treating the Japanese residing in Korea Noda-Oji was the first Japanese dentist for Japanese people in Korea in 1893. and Narajaki doyoyo, an invited dentist was posted in the Korean headquarter of Japanese army in september, 1905. The imperialist Japan licensed the dental technicians(yipchisa without limit and controled them generously so they could practice dentistry freely. This measure was contrary to that in Japan. (In Japan no new dental technician was licensed. Komori, a dental technician opened his laboratory at Chungmuro in 1902. The dental technician had outnumerbered by 1920. In 1907, the first Korean dental technician Sung-Ryong Choi practiced dentistry in Jongno. The imperialist Japan made the regulation for dental technicians to set a limit to the advertisement and medical practice of dental technicians. The first Korean dentist Suk-Tae Ham was registered No. 1 in the dentist license. The Kyungsung dental school was established by Nagira Dasoni for the purpose of educating some korean people that contributed to Japanese colonization. It made progress with the help of Japan. it was given the approval of the establishment of the professional school in January the 25th, 1929. it was intended to produce Korean dentists in the first place but became the school for Japanese students later on. The association of Chosun dentist, which had been founded by Narajaki doyoyo, was managed by Japanese dentists in favor of the colonial ruling. The Hansung Association of Dentists established in 1925 was the organization made by the necessity of the association for Koreans only. the Japanese forcefully annexed the Association of Hansung Dentists (Koreans only to the Association of Kyungsung Dentists to avoid collective actions of Korean dentists in the name of 'Naesunilche'--'Japan and Korea are one'. Their invading intention was shown in the event of 'decayed tooth preventive day'. Japanese

  9. A composer’s inner biography a sketch for the study of influences in Ljubica Marić’s oeuvre

    Directory of Open Access Journals (Sweden)

    Melita Milin

    2004-01-01

    Full Text Available Attempting to investigate works of music through frank examination of possible influences is a delicate thing, sometimes maybe dangerous - as has been suggested by Jonathan Cross in his book, The Stravinsky Legacy. While the originality of a composer may appear to be threatened with such types of critique, for musicologists it is important to draw upon a deeper appreciation for how a composer searched for his/her own creative voice. The music of Ljubica Marić (1909-2003, one of the most important Serbian composers of the 20th century, has been chosen to demonstrate how composers need different influences during different phases of their maturation and how they deeply integrate them in order to create an individual utterance. Ljubica Marić first studied composition with Josip Slavenski at the Belgrade Music School (1925-29, and continued her studies with Josef Suk at the Master School of the Prague Conservatory (1929-32 where she obtained her diploma. Finally, she took Alois Hába’s course in quarter-tone music at the same institution from 1936 to 1937. The works she composed during the 1930’s were characterized by a radical will to break ties with traditional, mainly romantic music, so she chose to be influenced by the free atonal pre-dodecaphonic works of Arnold Schoenberg. Following World War II, she introduced some changes of expression that were more in keeping with links from the past. Her music became tonally stabilized, and thematic-motivational developments were rediscovered, resulting in an expression that became milder. But the changes need not necessarily be linked exclusively to the post-war climate of socialist realism. Rather, the previous style may have met up with some type of impasse - the sort that confounds or ultimately transforms an artist. For Ljubica Marić, however, it appears she was never truly satisfied with her first post-war works (1945-1950. What is certain is that she composed nothing during the several years

  10. Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide

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    Jeong HU

    2015-01-01

    Full Text Available Hyeon-Uk Jeong,1 Mihwa Kwon,2 Yongnam Lee,3 Ji Seok Yoo,3 Dae Hee Shin,3 Im-Sook Song,2 Hye Suk Lee1 1College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea; 2College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 702-701, Korea; 3Central R&D Institute, Yungjin Pharm Co., Ltd., Suwon 443-270, Korea Abstract: We investigated the in vitro transport characteristics of catalposide in HEK293 cells overexpressing organic anion transporter 1 (OAT1, OAT3, organic anion transporting polypeptide 1B1 (OATP1B1, OATP1B3, organic cation transporter 1 (OCT1, OCT2, P-glycoprotein (P-gp, and breast cancer resistance protein (BCRP. The transport mechanism of catalposide was investigated in HEK293 and LLC-PK1 cells overexpressing the relevant transporters. The uptake of catalposide was 319-, 13.6-, and 9.3-fold greater in HEK293 cells overexpressing OAT3, OATP1B1, and OATP1B3 transporters, respectively, than in HEK293 control cells. The increased uptake of catalposide via the OAT3, OATP1B1, and OATP1B3 transporters was decreased to basal levels in the presence of representative inhibitors such as probenecid, furosemide, and cimetidine (for OAT3 and cyclosporin A, gemfibrozil, and rifampin (for OATP1B1 and OATP1B3. The concentration-dependent OAT3-mediated uptake of catalposide revealed the following kinetic parameters: Michaelis constant (Km =41.5 µM, maximum uptake rate (Vmax =46.2 pmol/minute, and intrinsic clearance (CLint =1.11 µL/minute. OATP1B1- and OATP1B3-mediated catalposide uptake also showed concentration dependency, with low CLint values of 0.035 and 0.034 µL/minute, respectively. However, the OCT1, OCT2, OAT1, P-gp, and BCRP transporters were apparently not involved in the uptake of catalposide into cells. In addition, catalposide inhibited the transport activities of OAT3, OATP1B1, and OATP1B3 with half-maximal inhibitory concentration values of 83, 200, and 235 µ

  11. PEMETAAN KOMPETENSI, SIKAP, TANGGUNG JAWAB, DAN JUMLAH JAM GURU BERSERTIFIKAT PENDIDIK DALAM MENGELOLA PEMBELAJARAN DI SMK

    Directory of Open Access Journals (Sweden)

    Hari Amanto

    2014-05-01

    Full Text Available Competency, Attitude, Responsibility, and Number of Hours of Educator Cer­­­­t­i­­fied Teachers on Managing Learning in SMK.The objective of this research is to des­cribe the competency, attitude, responsibility, and number of hours of educator cer­­tified teachers on managing learning in public vocational high school in Malang. This research employs a descriptive-quantitative approach. The research sub­jects are the educator certified teachers in SMKN Malang area. The instruments used to collect data are observation sheet, questionnaire, and documentation. Data is analyzed using per­cen­tag­e. The re­sults of this research show that: (1 the profiles of pedagogical com­pe­tency, attitude, so­­cial, and pro­fessional variables are categorized as competent, (2 the profiles of cog­nitive, and conative attitude are categorized as good, (3 affective attitude is ca­te­go­ri­z­­ed as ve­ry good, (4 the responsibility on applying the curriculum development is categorized as very high, (5 the performance of learning process is categorized as very high, (6 the process of conceling students ca­te­go­ry ve­­ry high, and (7 the total number of managing learn­­ing ho­urs is ca­t­egorized as qualified.   Tujuan penelitian ini un­tuk mendeskripsikan kompetensi, sikap, tang­gung jawab, dan jumlah jam guru bersertifikat pendidik dalam me­nge­lola pembelajaran pada SMK Negeri se-Malang Raya. Pe­nelitian ini menggunakan rancangan penelitian des­krip­­tif kuantitatif, dengan subjek pe­ne­litian guru bersertifikat pendidik SMKN se-Ma­lang Raya. Instrumen penelitian yang digunakan adalah lembar pengamatan, angket dan dokumentasi. Data di­ana­lisis dengan persentase. Hasil penelitian me­nun­juk­­­­kan bahwa: (1 kompetensi pe­da­­gogik, kepribadian, sosial, dan profesional ma­suk kate­­­gori kompeten, (2 sikap kog­ni­tif, konatif kategori baik, (3 sikap afektif kategori sangat baik, (4 tanggung jawab

  12. The comparative immunotoxicity of mesoporous silica nanoparticles and colloidal silica nanoparticles in mice

    Directory of Open Access Journals (Sweden)

    Lee S

    2013-01-01

    Full Text Available Soyoung Lee,1,* Mi-Sun Kim,1,* Dakeun Lee,2 Taeg Kyu Kwon,3 Dongwoo Khang,4 Hui-Suk Yun,5 Sang-Hyun Kim11CMRI, Laboratory of Immunotoxicology, Department of Pharmacology,School of Medicine, Kyungpook National University, Daegu, Republic of Korea; 2Department of Pathology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; 3Department of Immunology, School of Medicine, Keimyung University, Daegu, Republic of Korea; 4School of Nano and Advanced Materials Science and Engineering, Gyeongsang National University, Jinju, Republic of Korea; 5Engineering Ceramics Department, Powder and Ceramics Division, Korea Institute of Materials Science, Changwon, Republic of Korea*These authors contributed equally to this workBackground: Mesoporous silica (MPS nanoparticles (NPs, which have a unique pore structure and extremely large surface area and pore volume, have received much attention because of their biomedical application potential. Using MPS NPs for biomedical devices requires the verification of their biocompatibility because the surface area of NPs is one of the most important determinants of toxicity, including the cellular uptake and immune response. We have previously reported that the cytotoxicity and inflammation potential of MPS NPs have been shown to be lower than those of general amorphous colloidal silica (Col NPs in macrophages, but the low cytotoxicity does not guarantee high biocompatibility in vivo. In this study, we compared the in vivo immunotoxicity of MPS and Col NPs in the mouse model to define the effects of pore structural conditions of silica NPs.Materials and methods: Both MPS and Col NPs (2, 20, and 50 mg/kg/day were intraperitoneally administered in female BALB/c mice for 4 weeks, and clinical toxicity, lymphocyte population, serum IgG/IgM levels, and histological changes were examined.Results: There was no overt sign of clinical toxicity in either MPS- or Col-treated mice. However, MPS NPs led to

  13. Eyebrow Shapes of Chinese Empresses of the Ming and Qing Dynasties.

    Science.gov (United States)

    Hwang, Kun; Yoo, Seong Kyung

    2018-03-14

    The aim of this study was to analyze eyebrow shapes in portraits of Chinese empresses of Ming and Qing dynasties.The frontal portraits of 20 Ming empresses and 24 of Qing in which the eye and eyebrows were identifiable were measured and analyzed. The arch shape did not differ significantly (P > 0.05) between Ming and Qing. The head-up type (66.6%) was significantly more common (P Qing empresses were classified as 5 arch types: L (Lamas), A (Anastasia), H (Hwang), M (Empress Ma), and D (Empress Du). In Ming, type-H (45.0%) was the most frequent, followed by type-D (25.0%). In Qing, type-L (45.8%) was the most frequent, followed by type-H (16.7%) and type-D (16.7%). The relative eyebrow width (REW) of Ming and Qing was 1.59 ± 0.28. The REW of Qing (1.63 ± 0.30) and Ming (1.55 ± 0.26) did not differ significantly. The relative medial height (RMH, 1.05 ± 0.20) and relative lateral height (RLH; 1.05 ± 0.21) were the same, and greater than the relative mid-pupillary height (RPH; 0.84 ± 0.19; P Qing (1.02 ± 0.16) did not differ significantly. The RLH likewise did not differ significantly between Ming (1.01 ± 0.21) and Qing (1.08 ± 0.22). However, the RPH of Ming (0.91 ± 0.21) was significantly (P = 0.042) greater than Qing (0.79 ± 0.17). The relative brow thickness (RBT) of Qing (0.13 ± 0.06) was significantly (p = 0.033) greater than Ming (0.17 ± 0.06). The RBT of Ming and Qing was 0.15 ± 0.06 and increased with time (P = 0.023).The results of this study may be useful for brow lift or the tattooing.

  14. Enhancement of the dissolution rate and bioavailability of fenofibrate by a melt-adsorption method using supercritical carbon dioxide

    Directory of Open Access Journals (Sweden)

    Cha KH

    2012-10-01

    Full Text Available Kwang-Ho Cha,1,3 Kyung-Jin Cho,3 Min-Soo Kim,4 Jeong-Soo Kim,3 Hee Jun Park,1,3 Junsung Park,1,3 Wonkyung Cho,1,3 Jeong-Sook Park,3 Sung-Joo Hwang1,21Yonsei Institute of Pharmaceutical Sciences, 2College of Pharmacy, Yonsei University, Incheon, Republic of Korea; 3College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea; 4Department of Pharmaceutical Engineering, Inje University, Gimhae, Republic of KoreaBackground: The aim of this study was to enhance the bioavailability of fenofibrate, a poorly water-soluble drug, using a melt-adsorption method with supercritical CO2.Methods: Fenofibrate was loaded onto Neusilin® UFL2 at different weight ratios of fenofibrate to Neusilin UFL2 by melt-adsorption using supercritical CO2. For comparison, fenofibrate-loaded Neusilin UFL2 was prepared by solvent evaporation and hot melt-adsorption methods. The fenofibrate formulations prepared were characterized by differential scanning calorimetry, powder x-ray diffractometry, specific surface area, pore size distribution, scanning electron microscopy, and energy-dispersive x-ray spectrometry. In vitro dissolution and in vivo bioavailability were also investigated.Results: Fenofibrate was distributed into the pores of Neusilin UFL2 and showed reduced crystal formation following adsorption. Supercritical CO2 facilitated the introduction of fenofibrate into the pores of Neusilin UFL2. Compared with raw fenofibrate, fenofibrate from the prepared powders showed a significantly increased dissolution rate and better bioavailability. In particular, the area under the drug concentration-time curve and maximal serum concentration of the powders prepared using supercritical CO2 were 4.62-fold and 4.52-fold greater than the corresponding values for raw fenofibrate.Conclusion: The results of this study highlight the usefulness of the melt-adsorption method using supercritical CO2 for improving the bioavailability of fenofibrate.Keywords: fenofibrate

  15. Natural course of early COPD

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    Rhee CK

    2017-02-01

    Full Text Available Chin Kook Rhee,1 Kyungjoo Kim,1 Hyoung Kyu Yoon,2 Jee-Ae Kim,3 Sang Hyun Kim,4 Sang Haak Lee,5 Yong Bum Park,6 Ki-Suck Jung,7 Kwang Ha Yoo,8 Yong Il Hwang7 1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 3Pharmaceutical Policy Evaluation Research Team, Research Institution, 4Big Data Division, Health Insurance Review and Assessment Service, Wonju, 5Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, 6Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, 7Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, 8Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea Background and objective: Few studies have examined the natural course of early COPD. The aim of this study was to observe the natural course of early COPD patients. We also aimed to analyze medical utilization and costs for early COPD during a 6-year period. Methods: Patients with early COPD were selected from Korean National Health and Nutrition Examination Survey (KNHANES data. We linked the KNHANES data of patients with early COPD to National Health Insurance data. Results: A total of 2,397 patients were enrolled between 2007 and 2012. The mean forced expiratory volume in 1 second (FEV1 was 78.6%, and the EuroQol five dimensions questionnaire (EQ-5D index value was 0.9. In total, 110 patients utilized health

  16. Lifetime risks, loss of life expectancy, and health care expenditures for 19 types of cancer in Taiwan

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    Wu TY

    2018-05-01

    Full Text Available Tzu-Yi Wu,1 Chia-Hua Chung,2 Chia-Ni Lin,3 Jing-Shiang Hwang,2 Jung-Der Wang3,4 1Institute of Economics, Academia Sinica, Taipei, Taiwan; 2Institute of Statistical Science, Academia Sinica, Taipei, Taiwan; 3Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 4Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Background: The mortality rates for different cancers are no longer an efficient tool for making national policy. The purpose of this study were to quantify the lifetime risks, life expectancies (LEs after diagnosis, expected years of life lost (EYLL, and lifetime health care expenditures for 19 major cancers in Taiwan. Methods: A total of 831,314 patients with 19 pathologically proven cancers were abstracted from the Taiwan Cancer Registry from 1998 to 2012. They were linked to the National Mortality Registry (1998–2014 and National Health Insurance reimbursement database (1998–2013 for survival and health care costs. We estimated the cumulative incidence rate for ages 0–79 years and the lifetime survival function for patients with different cancer sites. The EYLL was calculated by subtracting the LE of each cancer cohort from that of the age- and sex-matched referents simulated from national life tables. The estimated lifetime cost was calculated by adding up the product of survival probability and mean cost at the corresponding duration-to-date after adjustment for the inflation to the year of 2013. Results: There were 5 cancers with a lifetime risk exceeding 4%: colorectal, liver, lung, and prostate in males, and breast and colorectal in females. Cancers with EYLL of >10 years were: esophageal, intrahepatic bile ducts, liver, pancreas, oral, nasopharyngeal, leukemia, lung, and gallbladder, extrahepatic bile ducts and biliary tract in males, and intrahepatic bile ducts

  17. Molecular modelling and radiopharmaceutical design

    International Nuclear Information System (INIS)

    Neves, M.; Gano, L.; Costa, M.C.; Raminhos, H.; Rosado, M.; Fausto, R.

    2002-01-01

    Aim: Among several headings for radiopharmaceuticals (RPs) design, molecular modelling (MM) could be used for the prediction of ligands and metal-complexes structures. Using MM it is also possible to simulate molecular interactions between predicted structures and specific biomolecules. Bisphosphonates (BPs) are ligands that are able to coordinate radioactive metals, such as 153 Sm, 166 Ho, 186 Re, etc., but they are all polymeric complexes difficult to characterize. It is reported that the bone uptake does not depend on the nature of metal center, but is primarily driven by the nature of the ligand, as in the case of HEDP-M (M= 99m Tc, 186 Re, 113 Sn). So, it would be interesting to estimate the relevant molecular properties of BPs by MM, simulate their interaction with hydroxyapatite (HAP) the main bone component, and then correlate the predicted molecular parameters with experimental data obtained from HAP binding and biodistribution studies of BPs carrying radioactive metals. Materials and Methods: The molecular structures and preferred conformations of BPs differing in the length of the aliphatic chain attached to their substituted amine groups (pami-dronate, olpadronate and ibandronate) were obtained using the second-generation CVFF 950 (version 1.01) force field of Hwang et al. Simulation of the interactions between the studied BPs and HAP were performed using a Cerius-2 system of programs running on a Silicon Graphics O2 workstation. BPs- 153 Sm complexes were synthesized and characterized by ITLC. Their binding to HAP and in vivo biodistribution studies were carried out as usual described in literature. Results: A direct correlation could be established between in vitro BPs affinity towards HAP and their corresponding energies from the Coulomb interactions involving the N and P atoms of the studied BPs bound to the HAP (0,0,1) surface and the nearest Ca atoms of HAP. The BPs- 153 Sm showing the highest binding to HAP and skeletal uptake are those which

  18. Environmental change on tidal flat induced by anthropogenic effect around west coast of Korean Peninsula

    Science.gov (United States)

    Lee, Yoon-Kyung; Choi, Jong-Kuk; Ryu, Joo-Hyung; Eom, Jinah

    2014-05-01

    Tidal flats are valuable ecosystem by a productive flora and fauna which support large populations of birds, form nursery and feeding areas for coastal fisheries, provide intrinsic values such as aesthetics and education (Costanza et al., 1997; Goodwin et al., 2001). The half of the world's coastal wetlands will submerge during this century in response to sea level rise although salt marsh has a capacity to adjust to sea level rise change. However, tidal flats have been changed because of several coastal construction projects that had not been considered sustainable over the last 30 years in Korean Peninsula. The total area of tidal flats decreased from approximately 2,800 km2 in 1990 to 2,393 km2 in 2005 due to the land reclamations and dredging in South Korea. Many researchers investigated topography, sedimentation changes and local hydrodynamics for this area in the early 1990s. However, they are limited to the temporal and spatial scale because field surveys in the tidal flats are restricted due to the difficulties in accessing. The aim of this study was to examine environmental change in tidal flat in a large scale for long-term based on the remotely sensed data as well as in situ measurements. This study focused on the tidal flat that not only had been affected by reclamations on a large scale such as Ganghwa and Saemangeum but also had been indirectly affected by reclamations such as Hwang-do and Gomso-bay. In this study, changes in morphology and sedimentary facies in tidal flats were estimated. Digital elevation models (DEMs) in early 2000 and 2010 were generated based on the Landsat TM/ETM+ images using a waterline method. Morphological change was estimated based on the differences of DEMs and sedimentary facies was investigated based on the calculation of image-derived PCA coefficient. Results of the morphological change in tidal flats interestingly showed that large amount of areas had been deposited whereas the other areas were eroded. Area with

  19. The development of radioimmunoassay systems for the human pituitary gland

    International Nuclear Information System (INIS)

    Simionescu, L.

    1983-11-01

    The aim of the study was the preparation of 1. Human Growth Hormone (HGH), 2. The glycoprotein hormones: Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH) and Thyroid Stimulating Hormone (TSH), 3. The Prolactin. 1. A standardised procedure for the preparation of HGH ''clinical grade'' was developed. This HGH can be applied for the treatment of children diagnosed as hypophyseal dwarfism; the preliminary results are encouraging. The final ethanol-soluble fraction is used also for the prolactin preparation. As shown by exclusion chromatography, the lyophilized HGH ''clinical grade'' contains mainly its monomeric form. The purified HGH obtained by processing of frozen glands is suitable as antigen for the preparation of antisera in rabbits. Large quantities of purified HGH were prepared, used as preparation for radioiodination, and proposed as a national reference preparation for immunoassay. The double antibody HGH-RIA system using author's procedure seems to be adequate for the HGH measurements in biological fluids. 2. Using two chromatographic steps (Sephadex G-150, DEAE-cellulose) followed by a preparative electrophoresis (P-PAGE) purified LH was obtained. The measurement of the β-TSH in the P-PAGE eluates showed concentrations lower than the sensitivity limit of the β-TSH RIA system (5microU/ml). The three chromatographic steps (Sephadex G-150, DEAE-cellulose and Sephadex G-100) allowed to separate the FSH from TSH during the third step, FSH being eluted faster than TSH, as resulted from the RIA measurements of the FSH and of β-TSH: Some overlapping of the concentrations of these hormones was observed only in eluates on the descending arm of the FSH peak. 3. The procedure for the isolation and purification of prolactin was developed according to Hwang's method. The extraction procedure started with the discarded step during the HSH ''clinical grade'' preparation and included three chromatographic steps for purification. However, the final product

  20. Estimating Source Duration for Moderate and Large Earthquakes in Taiwan

    Science.gov (United States)

    Chang, Wen-Yen; Hwang, Ruey-Der; Ho, Chien-Yin; Lin, Tzu-Wei

    2017-04-01

    Estimating Source Duration for Moderate and Large Earthquakes in Taiwan Wen-Yen Chang1, Ruey-Der Hwang2, Chien-Yin Ho3 and Tzu-Wei Lin4 1 Department of Natural Resources and Environmental Studies, National Dong Hwa University, Hualien, Taiwan, ROC 2Department of Geology, Chinese Culture University, Taipei, Taiwan, ROC 3Department of Earth Sciences, National Cheng Kung University, Tainan, Taiwan, ROC 4Seismology Center, Central Weather Bureau, Taipei, Taiwan, ROC ABSTRACT To construct a relationship between seismic moment (M0) and source duration (t) was important for seismic hazard in Taiwan, where earthquakes were quite active. In this study, we used a proposed inversion process using teleseismic P-waves to derive the M0-t relationship in the Taiwan region for the first time. Fifteen earthquakes with MW 5.5-7.1 and focal depths of less than 40 km were adopted. The inversion process could simultaneously determine source duration, focal depth, and pseudo radiation patterns of direct P-wave and two depth phases, by which M0 and fault plane solutions were estimated. Results showed that the estimated t ranging from 2.7 to 24.9 sec varied with one-third power of M0. That is, M0 is proportional to t**3, and then the relationship between both of them was M0=0.76*10**23(t)**3 , where M0 in dyne-cm and t in second. The M0-t relationship derived from this study was very close to those determined from global moderate to large earthquakes. For further understanding the validity in the derived relationship, through the constructed relationship of M0-, we inferred the source duration of the 1999 Chi-Chi (Taiwan) earthquake with M0=2-5*10**27 dyne-cm (corresponding to Mw = 7.5-7.7) to be approximately 29-40 sec, in agreement with many previous studies for source duration (28-42 sec).

  1. Chronic depression treated successfully with novel taping therapy: a new approach to the treatment of depression

    Directory of Open Access Journals (Sweden)

    Han CH

    2016-06-01

    Full Text Available Chang Hyun Han,1,* Hwa Soo Hwang,2,* Young Joon Lee,3 Sang Nam Lee,4 Jane J Abanes,5 Bong Hyo Lee6 1Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon, 2Chims-Saengvit Oriental Medicine Clinic, Seoul, 3Department of Preventive Korean Medicine, 4Department of Qigong, College of Korean Medicine, Daegu Haany University, Gyeongsangbuk-do, South Korea; 5Daniel K Inouye Graduate School of Nursing, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; 6Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu, South Korea *These authors contributed equally to this work Introduction: Despite improved research in the treatment, depression remains difficult to treat. Till date, successful treatment of depression using taping therapy has not been known yet. We report cases where patients with severe depressive symptoms were successfully treated by taping therapy, a new approach.Methods: In case 1, a patient was taking several psychiatric medications for 10 years and admitted often to the psychiatric hospital with a leaning head, flexible legs, and nearly closed eyes; in case 2, a patient after a hysterectomy complained with heart palpitations, depressive- and anxiety-like behaviors, insomnia, and gastrointestinal problems; and in case 3, a patient with complaints of adverse effects from antidepressant medications had suicidal thoughts frequently. The medical tapes were placed on acupoints, trigger points, and pain points found by finger pressing examination in the chest, sides, and upper back of the patients.Results: In case 1, the patient started weeping immediately after the first treatment. He discontinued psychiatric drugs and returned to baseline functioning after 2 months. In case 2, the patient felt at ease showing decreased palpitation immediately after the first treatment, and after 1 week, she quit medications. In case 3, the patient experienced a

  2. α-Methylprednisolone conjugated cyclodextrin polymer-based nanoparticles for rheumatoid arthritis therapy

    Directory of Open Access Journals (Sweden)

    Jungyeon Hwang

    2008-10-01

    Full Text Available Jungyeon Hwang1, Kathleen Rodgers2, James C Oliver3, Thomas Schluep11Insert Therapeutics, Inc., Pasadena, CA, USA; 2Livingston Research Institute, Los Angeles, CA, USA; James C Oliver, Peptagen, Inc., Raleigh, NC USAAbstract: A glycinate derivative of α-methylprednisolone (MP was prepared and conjugated to a linear cyclodextrin polymer (CDP with a loading of 12.4% w/w. The polymer conjugate (CDP-MP self-assembled into nanoparticles with a size of 27 nm. Release kinetics of MP from the polymer conjugate showed a half-life (t1/2 of 50 h in phosphate buffer solution (PBS and 19 h in human plasma. In vitro, the proliferation of human lymphocytes was suppressed to a similar extent but with a delayed effect when CDP-MP was compared with free MP. In vivo, CDP-MP was administered intravenously to mice with collagen-induced arthritis and compared with free MP. CDP-MP was administered weekly for six weeks (0.07, 0.7, and 7 mg/kg/week and MP was administered daily for six weeks (0.01, 0.1, and 1 mg/kg/day. Body weight changes were minimal in all animals. After 28 days, a significant decrease in arthritis score was observed in animals treated weekly with an intermediate or high dose of CDP-MP. Additionally, dorsoplantar swelling was reduced to baseline in animals treated with CDP-MP at the intermediate and high dose level. Histological evaluation showed a reduction in synovitis, pannus formation and disruption of architecture at the highest dose level of CDP-MP. MP administered daily at equivalent cumulative doses showed minimal efficacy in this model. This study demonstrates that conjugation of MP to a cyclodextrin-polymer may improve its efficacy, leading to lower doses and less frequent administration for a safer and more convenient management of rheumatoid arthritis.Keywords: α-methylprednisolone (MP, cyclodextrin polymer (CDP, polymer conjugate (CDP-MP, rheumatoid arthritis (RA, enhanced permeability and retention effect (EPR

  3. Material Removal and Specific Energy in the Dynamic Scratching of Gamma Titanium Aluminides

    Energy Technology Data Exchange (ETDEWEB)

    Wang, H.; Lin, H.-T.; Wereszczak, A.A.

    2006-11-30

    Mechanical responses of three gamma titanium aluminides (TiAls) (denoted as Alloy A, Alloy B and Alloy C) subjected to dynamic scratching were studied by using a single-grit pendulum (rotating) scratch tester. The maximum depth of groove was {approx} 0.07 mm, and the scratch velocity was {approx} 1.0 m/s. Normal and tangential forces were monitored. The material removal mechanisms were examined using a scanning electron microscope (SEM) and the scratches were measured by using a laser profilometer. The mechanical properties of the tested TiAls were characterized by the instantaneous specific energy, scratch resistance and scratch hardness as related to the groove depth. Extensive thermal softening was observed in the dynamic scratch test of the TiAls, which facilitated both the detachment of developing chips and pile-up of material on side ridges. Sizable fractures were observed in the transverse direction in the tested TiAls; these fractures tended to participate in the chip formation, depending on the microstructure of the TiAl and the size of the scratch groove. Specific energy and scratch hardness are depth-dependent to various degrees for the TiAls tested. The material removal might be subjected to different mechanisms, but the overall material response can be effectively characterized by the HEM (Hwang, Evans and Malkin) model and the PSR (proportional specimen resistance) model. The depth-independent specific energy and scratch hardness can be used to screen candidate materials for the applications that are scratch-dominated versus impact-dominated. Among the three tested TiAls, the TiAl with larger colony or grain size exhibits a stronger capability of energy dissipation during material removal (higher depth-independent specific energy), while the TiAl with smaller colony size shows a higher resistance to indentation (higher depth-independent scratch hardness). The observations and conclusions in this study can serve as a base line for the further

  4. Material Removal and Specific Energy in the Dynamic Scratching of Gamma Titanium Aluminides

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Hong [ORNL; Lin, Hua-Tay [ORNL; Wereszczak, Andrew A [ORNL

    2006-11-01

    Mechanical responses of three gamma titanium aluminides (TiAls) (denoted as Alloy A, Alloy B and Alloy C) subjected to dynamic scratching were studied by using a single-grit pendulum (rotating) scratch tester. The maximum depth of groove was ~ 0.07 mm, and the scratch velocity used was ~ 1.0 m/s. Normal and tangential forces were monitored. The material removal mechanisms were examined using a scanning electron microscope (SEM) and the scratches were measured by using a laser profilometer. The mechanical properties of the tested TiAls were characterized by the instantaneous specific energy, scratch resistance and scratch hardness as related to the depth of groove. Extensive thermal softening was observed in the dynamic scratch of the tested TiAls, which facilitated both the detachments of developing chips and the pile-ups of materials on side ridges. Sizable fractures were observed in the transverse direction on the tested TiAls; these fractures tended to participate in the chip formation, depending on the microstructure of the TiAl and the size of the scratch groove. Specific energy and scratch hardness are depth-dependent to various degrees for the tested TiAls. The materiel removal might be subjected to different mechanisms, but the overall response of materials can be effectively characterized by the HEM (Hwang, Evans and Malkin) model and the PSR (proportional specimen resistance) model. The obtained depth-independent specific energy and scratch hardness can be used to screen the candidate materials for the specific purpose depending on whether the application is scratch-dominant or impact-dominant. Among the three tested TiAls, the TiAl with larger colony or grain size exhibits a stronger capability of energy dissipation in the material loss or material removal (higher depth-independent specific energy), while the TiAl with smaller colony size show a higher resistance against the indentation (higher depth-independent scratch hardness). The observations and

  5. Satellite Remote Sensing of Ocean Winds, Surface Waves and Surface Currents during the Hurricanes

    Science.gov (United States)

    Zhang, G.; Perrie, W. A.; Liu, G.; Zhang, L.

    2017-12-01

    Hurricanes over the ocean have been observed by spaceborne aperture radar (SAR) since the first SAR images were available in 1978. SAR has high spatial resolution (about 1 km), relatively large coverage and capability for observations during almost all-weather, day-and-night conditions. In this study, seven C-band RADARSAT-2 dual-polarized (VV and VH) ScanSAR wide images from the Canadian Space Agency (CSA) Hurricane Watch Program in 2017 are collected over five hurricanes: Harvey, Irma, Maria, Nate, and Ophelia. We retrieve the ocean winds by applying our C-band Cross-Polarization Coupled-Parameters Ocean (C-3PO) wind retrieval model [Zhang et al., 2017, IEEE TGRS] to the SAR images. Ocean waves are estimated by applying a relationship based on the fetch- and duration-limited nature of wave growth inside hurricanes [Hwang et al., 2016; 2017, J. Phys. Ocean.]. We estimate the ocean surface currents using the Doppler Shift extracted from VV-polarized SAR images [Kang et al., 2016, IEEE TGRS]. C-3PO model is based on theoretical analysis of ocean surface waves and SAR microwave backscatter. Based on the retrieved ocean winds, we estimate the hurricane center locations, maxima wind speeds, and radii of the five hurricanes by adopting the SHEW model (Symmetric Hurricane Estimates for Wind) by Zhang et al. [2017, IEEE TGRS]. Thus, we investigate possible relations between hurricane structures and intensities, and especially some possible effects of the asymmetrical characteristics on changes in the hurricane intensities, such as the eyewall replacement cycle. The three SAR images of Ophelia include the north coast of Ireland and east coast of Scotland allowing study of ocean surface currents respond to the hurricane. A system of methods capable of observing marine winds, surface waves, and surface currents from satellites is of value, even if these data are only available in near real-time or from SAR-related satellite images. Insight into high resolution ocean winds

  6. The association between whole body sagittal balance and risk of falls among elderly patients seeking treatment for back pain.

    Science.gov (United States)

    Kim, J; Hwang, J Y; Oh, J K; Park, M S; Kim, S W; Chang, H; Kim, T-H

    2017-05-01

    The objective of this study was to assess the association between whole body sagittal balance and risk of falls in elderly patients who have sought treatment for back pain. Balanced spinal sagittal alignment is known to be important for the prevention of falls. However, spinal sagittal imbalance can be markedly compensated by the lower extremities, and whole body sagittal balance including the lower extremities should be assessed to evaluate actual imbalances related to falls. Patients over 70 years old who visited an outpatient clinic for back pain treatment and underwent a standing whole-body radiograph were enrolled. Falls were prospectively assessed for 12 months using a monthly fall diary, and patients were divided into fallers and non-fallers according to the history of falls. Radiological parameters from whole-body radiographs and clinical data were compared between the two groups. A total of 144 patients (120 female patients and 24 male patients) completed a 12-month follow-up for assessing falls. A total of 31 patients (21.5%) reported at least one fall within the 12-month follow-up. In univariate logistic regression analysis, the risk of falls was significantly increased in older patients and those with more medical comorbidities, decreased lumbar lordosis, increased sagittal vertical axis, and increased horizontal distance between the C7 plumb line and the centre of the ankle (C7A). Increased C7A was significantly associated with increased risk of falls even after multivariate adjustment. Whole body sagittal balance, measured by the horizontal distance between the C7 plumb line and the centre of the ankle, was significantly associated with risk of falls among elderly patients with back pain. Cite this article : J. Kim, J. Y. Hwang, J. K. Oh, M. S. Park, S. W. Kim, H. Chang, T-H. Kim. The association between whole body sagittal balance and risk of falls among elderly patients seeking treatment for back pain. Bone Joint Res 2017;6:-344. DOI: 10

  7. Precipitation of Oriented Rutile and Ilmenite Needles in Garnet, Northeastern Connecticut, USA: Evidence for Extreme Metamorphic Conditions?

    Science.gov (United States)

    Ague, J. J.; Eckert, J. O.

    2011-12-01

    We report the discovery of oriented needles of rutile and, less commonly, ilmenite in the cores of garnets from northeastern CT, USA. The rocks preserve granulite facies mineral assemblages, form part of the Merrimack Synclinorium, and underwent metamorphism and deformation during the Acadian orogeny. The needles appear identical to those reported from a number of extreme P-T environments worldwide, including UHP metamorphic rocks, high-P granulites, and garnet peridotites. The needles are predominantly oriented along directions in garnet. The long axes of the rutile needles commonly do not go extinct parallel to the cross hairs under cross-polarized light (e.g., Griffin et al., 1971). This anomalous extinction indicates that the needles do not preserve a specific crystallographic relationship with their garnet hosts (e.g., Hwang et al., 2007). The needles range from a few hundred nm to a few um in diameter, and can be mm-scale in length. Micrometer-scale plates of rutile, srilankite and crichtonite have also been observed in some garnets together with the Fe-Ti oxide needles. Several origins for the needles have been proposed in the literature; we investigate the hypothesis that they precipitated in situ from originally Ti-rich garnet. Chemical profiles across garnets indicate that some retain Ti zoning, with elevated-Ti concentrations in the cores dropping to low values in the rims. For these zoned garnets, high-resolution, 2-D chemical mapping using the JEOL JXA-8530F field emission gun electron microprobe at Yale University reveals that the needles are surrounded by well-defined Ti-depletion halos. Chemical profiles also document strong depletions of Cr (which is present in both rutile and ilmenite) directly adjacent to needles. The observed Ti-depletions demonstrate that the needles precipitated from Ti-bearing garnet, probably during cooling and/or decompression associated with exhumation. The rutile precipitates must be largely incoherent with respect to the

  8. Field study on behaviors and adaptation of elderly people and their thermal comfort requirements in residential environments.

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    Hwang, R-L; Chen, C-P

    2010-06-01

    This study investigated the thermal sensation of elderly people in Taiwan, older than 60 years, in indoor microclimate at home, and their requirements for establishing thermal comfort. The study was conducted using both a thermal sensation questionnaire and measurement of indoor climatic parameters underlying the thermal environment. Survey results were compared with those reported by Cheng and Hwang (2008, J. Tongji Univ., 38, 817-822) for non-elders to study the variation between different age groups in requirements of indoor thermal comfort. The results show that the predominant strategy of thermal adaptation for elders was window-opening in the summer and clothing adjustment in the winter. The temperature of thermal neutrality was 25.2 degrees C and 23.2 degrees C for the summer and the winter, respectively. Logistically regressed probit modeling on percentage of predicted dissatisfied (PPD) against mean thermal sensation vote revealed that the sensation votes corresponding to a PPD of 20% were +/- 0.75 for elders, about +/- 0.10 less than the levels projected by ISO 7730 model. The range of operative temperature for 80% thermal acceptability for elders in the summer was 23.2-27.1 degrees C, narrower than the range of 23.0-28.6 degrees C reported for non-elders. This is likely a result of a difference in the selection of adaptive strategies. Taiwan in the last decade has seen a rapid growth in the elderly population in its societal structure, and as such the quality of indoor thermal comfort increasingly concerns the elderly people. This study presents the results from field-surveying elders residing in major geographical areas of Taiwan, and discusses the requirements of these elders for indoor thermal comfort in different seasons. Through a comparison with the requirements by non-elders, this study demonstrates the unique sensitivity of elders toward indoor thermal quality and the selection of adaptive strategies that need to be considered when a thermal

  9. The egg-sharing model for human therapeutic cloning research: managing donor selection criteria, the proportion of shared oocytes allocated to research, and amount of financial subsidy given to the donor.

    Science.gov (United States)

    Heng, Boon Chin; Tong, Guo Qing; Stojkovic, Miodrag

    2006-01-01

    Recent advances in human therapeutic cloning made by Hwang and colleagues have opened up new avenues of therapy for various human diseases. However, the major bottleneck of this new technology is the severe shortage of human donor oocytes. Egg-sharing in return for subsidized fertility treatment has been suggested as an ethically justifiable and practical solution to overcome the shortage of donor oocytes for therapeutic cloning. Because the utilization of shared oocytes in therapeutic cloning research does not result in any therapeutic benefit to a second party, this would necessitate a different management strategy compared to their use for the assisted conception of infertile women who are unable to produce any oocytes of their own. It is proposed that the pool of prospective egg-sharers in therapeutic cloning research be limited only to younger women (below 30 years of age) with indications for either male partner sub-fertility or tubal blockage. With regards to the proportion of the shared gametes being allocated to research, a threshold number of retrieved oocytes should be set that if not exceeded, would result in the patient being automatically removed from the egg-sharing scheme. Any excess supernumerary oocyte above this threshold number can be contributed to science, and allocation should be done in a randomized manner. Perhaps, a total of 10 retrieved oocytes from the patient may be considered a suitable threshold, since the chances of conception are unlikely to be impaired. With regards to the amount of subsidy being given to the patient, it is suggested that the proportion of financial subsidy should be equal to the proportion of the patient's oocytes being allocated to research. No doubt, the promise of future therapeutic benefit may be offered to the patient instead of financial subsidy. However, this is ethically controversial because therapeutic cloning has not yet been demonstrated to be a viable model of clinical therapy and any promises made to

  10. Circulating hematopoietic progenitors and CD34+ cells predicted successful hematopoietic stem cell harvest in myeloma and lymphoma patients: experiences from a single institution

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    Yu JT

    2016-02-01

    Full Text Available Jui-Ting Yu,1,2,* Shao-Bin Cheng,3,* Youngsen Yang,1 Kuang-Hsi Chang,4 Wen-Li Hwang,1 Chieh-Lin Jerry Teng,1,5,6 1Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, 2Division of Hematology/Medical Oncology, Tungs' Taichung MetroHarbor Hospital, 3Division of General Surgery, Department of Surgery, 4Department of Medical Research and Education, Taichung Veterans General Hospital, 5Department of Life Science, Tunghai University, 6School of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China *These authors contributed equally to this work Background: Previous studies have shown that the numbers of both circulating hematopoietic progenitor cell (HPC and CD34+ cell are positively correlated with CD34+ cell harvest yield. However, the minimal numbers of both circulating HPCs and CD34+ cells required for performing an efficient hematopoietic stem cell (HSC harvest in lymphoma and myeloma patients have not been defined in our institution. Patients and methods: Medical records of 50 lymphoma and myeloma patients undergoing peripheral blood HSC harvest in our institution were retrospectively reviewed. The minimal and optimal HSC harvest yield required for the treatment was considered to be ≥2×106 CD34+ cells/kg and ≥5×106 CD34+ cells/kg, respectively. Results: The minimally required or optimal HSC yield obtained was not influenced by age (≥60 years, sex, underlying malignancies, disease status, multiple rounds of chemotherapy, or history of radiotherapy. The numbers of both circulating HPC and CD34+ cell were higher in patients with minimally required HSC yields (P=0.000 for HPC and P=0.000 for CD34+ cell and also in patients with optimal HSC yields (P=0.011 for HPC and P=0.006 for CD34+ cell. The cell count cutoff for obtaining minimally required HSC harvest was determined to be 20/mm3 for HPCs and 10/mm3 for CD34+ cells. Furthermore, the cell count cutoff for obtaining

  11. Schisandrae fructus enhances myogenic differentiation and inhibits atrophy through protein synthesis in human myotubes

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    Kim CH

    2016-05-01

    Full Text Available Cy Hyun Kim,1,2,* Jin-Hong Shin,1,3,* Sung Jun Hwang,1,2 Yung Hyun Choi,4 Dae-Seong Kim,1,3 Cheol Min Kim2,51Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, 2Center for Anti-Aging Industry, Pusan National University, Busan, 3Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, 4Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan, 5Department of Biomedical Informatics, Pusan National University School of Medicine, Yangsan, Republic of Korea*These authors contributed equally to this work Abstract: Schisandrae fructus (SF has recently been reported to increase skeletal muscle mass and inhibit atrophy in mice. We investigated the effect of SF extract on human myotube differentiation and its acting pathway. Various concentrations (0.1–10 µg/mL of SF extract were applied on human skeletal muscle cells in vitro. Myotube area and fusion index were measured to quantify myotube differentiation. The maximum effect was observed at 0.5 µg/mL of SF extract, enhancing differentiation up to 1.4-fold in fusion index and 1.6-fold in myotube area at 8 days after induction of differentiation compared to control. Phosphorylation of eukaryotic translation initiation factor 4E-binding protein 1 and 70 kDa ribosomal protein S6 kinase, which initiate translation as downstream of mammalian target of rapamycin pathway, was upregulated in early phases of differentiation after SF treatment. SF also attenuated dexamethasone-induced atrophy. In conclusion, we show that SF augments myogenic differentiation and attenuates atrophy by increasing protein synthesis through mammalian target of rapamycin/70 kDa ribosomal protein S6 kinase and eukaryotic translation initiation factor 4E-binding protein 1 signaling pathway in human myotubes. SF can be a useful natural dietary supplement in increasing skeletal muscle mass, especially in the aged

  12. Optimized formulation of solid self-microemulsifying sirolimus delivery systems

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    Cho W

    2013-04-01

    Full Text Available Wonkyung Cho,1,2 Min-Soo Kim,3 Jeong-Soo Kim,2 Junsung Park,1,2 Hee Jun Park,1,2 Kwang-Ho Cha,1,2 Jeong-Sook Park,2 Sung-Joo Hwang1,4 1Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea; 2College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea; 3Department of Pharmaceutical Engineering, Inje University, Gimhae, Republic of Korea; 4College of Pharmacy, Yonsei University, Incheon, Republic of Korea Background: The aim of this study was to develop an optimized solid self-microemulsifying drug delivery system (SMEDDS formulation for sirolimus to enhance its solubility, stability, and bioavailability. Methods: Excipients used for enhancing the solubility and stability of sirolimus were screened. A phase-separation test, visual observation for emulsifying efficiency, and droplet size analysis were performed. Ternary phase diagrams were constructed to optimize the liquid SMEDDS formulation. The selected liquid SMEDDS formulations were prepared into solid form. The dissolution profiles and pharmacokinetic profiles in rats were analyzed. Results: In the results of the oil and cosolvent screening studies, Capryol™ Propylene glycol monocaprylate (PGMC and glycofurol exhibited the highest solubility of all oils and cosolvents, respectively. In the surfactant screening test, D-α-tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS was determined to be the most effective stabilizer of sirolimus in pH 1.2 simulated gastric fluids. The optimal formulation determined by the construction of ternary phase diagrams was the T32 (Capryol™ PGMC:glycofurol:vitamin E TPGS = 30:30:40 weight ratio formulation with a mean droplet size of 108.2 ± 11.4 nm. The solid SMEDDS formulations were prepared with Sucroester 15 and mannitol. The droplet size of the reconstituted solid SMEDDS showed no significant difference compared with the liquid SMEDDS. In the dissolution study, the release amounts of

  13. Characterization of two forms of mouse salivary androgen-binding protein (ABP): implications for evolutionary relationships and ligand-binding function.

    Science.gov (United States)

    Karn, Robert C; Laukaitis, Christina M

    2003-06-17

    Mouse salivary androgen-binding protein (ABP) is a member of the secretoglobin family produced in the submaxillary glands of house mice (Mus musculus). We report the cDNA sequences and amino acid sequences of the beta and gamma subunits of ABP from a mouse cDNA library, identifying the two subunits by their pIs and molecular weights. An anomalously high molecular weight of the alpha subunit is likely due to glycosylation at a single site. A phylogenetic comparison of the three subunits of ABP with the chains of other mammalian secretoglobins shows that ABP is most closely related to mouse lachrymal protein and to the major cat allergen Fel dI. An evaluation of the most conserved residues in ABP and the other secretoglobins, in light of structural data reported by others [Callebaut, I., Poupon, A., Bally, R., Demaret, J.-P., Housset, D., Delettre, J., Hossenlopp, P., and Mornon, J.-P. (2000) Ann. N.Y. Acad. Sci. 923, 90-112; Pattabiraman, N., Matthews, J., Ward, K., Mantile-Selvaggi, G., Miele, L., and Mukherjee, A. (2000) Ann. N.Y. Acad. Sci. 923, 113-127], allows us to draw conclusions about the critical residues important in ligand binding by the two different ABP dimers and to assess the importance of ligand binding in the function of the molecule. In addition to the cDNAs, which represent those of the musculus subspecies of Mus musculus, we also report the coding regions of the beta and gamma subunit cDNAs from two other mouse inbred strains which represent the other two subspecies: M. musculus domesticus and M. musculus castaneus. The high nonsynonymous/synonymous substitution rate ratios (K(a)/K(s)) for both the beta and gamma subunits suggest that these two proteins are evolving under strong directional selection, as has been reported for the alpha subunit [Hwang, J., Hofstetter, J., Bonhomme, F., and Karn, R. (1997) J. Hered. 88, 93-97; Karn, R., and Clements, M. (1999) Biochem. Genet. 37, 187-199].

  14. Impact of an Electronic Health Record-Integrated Personal Health Record on Patient Participation in Health Care: Development and Randomized Controlled Trial of MyHealthKeeper.

    Science.gov (United States)

    Ryu, Borim; Kim, Nari; Heo, Eunyoung; Yoo, Sooyoung; Lee, Keehyuck; Hwang, Hee; Kim, Jeong-Whun; Kim, Yoojung; Lee, Joongseek; Jung, Se Young

    2017-12-07

    ://www.webcitation.org/6v01HaCdd). ©Borim Ryu, Nari Kim, Eunyoung Heo, Sooyoung Yoo, Keehyuck Lee, Hee Hwang, Jeong-Whun Kim, Yoojung Kim, Joongseek Lee, Se Young Jung. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 07.12.2017.

  15. Decoy State Quantum Key Distribution

    Science.gov (United States)

    Lo, Hoi-Kwong

    2005-10-01

    Quantum key distribution (QKD) allows two parties to communicate in absolute security based on the fundamental laws of physics. Up till now, it is widely believed that unconditionally secure QKD based on standard Bennett-Brassard (BB84) protocol is limited in both key generation rate and distance because of imperfect devices. Here, we solve these two problems directly by presenting new protocols that are feasible with only current technology. Surprisingly, our new protocols can make fiber-based QKD unconditionally secure at distances over 100km (for some experiments, such as GYS) and increase the key generation rate from O(η2) in prior art to O(η) where η is the overall transmittance. Our method is to develop the decoy state idea (first proposed by W.-Y. Hwang in "Quantum Key Distribution with High Loss: Toward Global Secure Communication", Phys. Rev. Lett. 91, 057901 (2003)) and consider simple extensions of the BB84 protocol. This part of work is published in "Decoy State Quantum Key Distribution", . We present a general theory of the decoy state protocol and propose a decoy method based on only one signal state and two decoy states. We perform optimization on the choice of intensities of the signal state and the two decoy states. Our result shows that a decoy state protocol with only two types of decoy states--a vacuum and a weak decoy state--asymptotically approaches the theoretical limit of the most general type of decoy state protocols (with an infinite number of decoy states). We also present a one-decoy-state protocol as a special case of Vacuum+Weak decoy method. Moreover, we provide estimations on the effects of statistical fluctuations and suggest that, even for long distance (larger than 100km) QKD, our two-decoy-state protocol can be implemented with only a few hours of experimental data. In conclusion, decoy state quantum key distribution is highly practical. This part of work is published in "Practical Decoy State for Quantum Key Distribution

  16. Malignant gliomas: current perspectives in diagnosis, treatment, and early response assessment using advanced quantitative imaging methods

    Directory of Open Access Journals (Sweden)

    Ahmed R

    2014-03-01

    Full Text Available Rafay Ahmed,1 Matthew J Oborski,2 Misun Hwang,1 Frank S Lieberman,3 James M Mountz11Department of Radiology, 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; 3Department of Neurology and Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAAbstract: Malignant gliomas consist of glioblastomas, anaplastic astrocytomas, anaplastic oligodendrogliomas and anaplastic oligoastrocytomas, and some less common tumors such as anaplastic ependymomas and anaplastic gangliogliomas. Malignant gliomas have high morbidity and mortality. Even with optimal treatment, median survival is only 12–15 months for glioblastomas and 2–5 years for anaplastic gliomas. However, recent advances in imaging and quantitative analysis of image data have led to earlier diagnosis of tumors and tumor response to therapy, providing oncologists with a greater time window for therapy management. In addition, improved understanding of tumor biology, genetics, and resistance mechanisms has enhanced surgical techniques, chemotherapy methods, and radiotherapy administration. After proper diagnosis and institution of appropriate therapy, there is now a vital need for quantitative methods that can sensitively detect malignant glioma response to therapy at early follow-up times, when changes in management of nonresponders can have its greatest effect. Currently, response is largely evaluated by measuring magnetic resonance contrast and size change, but this approach does not take into account the key biologic steps that precede tumor size reduction. Molecular imaging is ideally suited to measuring early response by quantifying cellular metabolism, proliferation, and apoptosis, activities altered early in treatment. We expect that successful integration of quantitative imaging biomarker assessment into the early phase of clinical trials could provide a novel approach for testing new therapies

  17. Biodistribution of newly synthesized PHEA-based polymer-coated SPION in Sprague Dawley rats as magnetic resonance contrast agent

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    Park J

    2013-10-01

    Full Text Available Junsung Park,1,2,* Wonkyung Cho,1,2,* Hee Jun Park,1,2 Kwang-Ho Cha,1,2 Dae-Chul Ha,2,5 Youn-Woong Choi,5 Ha-Young Lee,3 Sun-Hang Cho,5 Sung-Joo Hwang1,4 1Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea; 2College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea; 3Biomaterials Laboratory, Korea Research Institutes of Chemical Technology, Daejeon, Republic of Korea; 4College of Pharmacy, Yonsei University, Incheon, Republic of Korea; 5Korea United Pharm Inc, Seoul, Republic of Korea *These authors contributed equally to this work Objectives: The purpose of this study was to observe the pharmacokinetic behavior of newly synthesized biocompatible polymers based on polyhydroxyethylaspartamide (PHEA to be used to coat an iron oxide core to make superparamagnetic iron oxide nanoparticles (SPION. Materials and methods: The isotopes [14C] and [59Fe] were used to label the polymer backbone (CLS and iron oxide core (FLS, respectively. In addition, unradiolabeled cold superparamagnetic iron oxide nanoparticles (SPION/ULS were synthesized to characterize particle size by dynamic light scattering, morphology by transmission electron microscopy, and in vivo magnetic resonance imaging (MRI. CLS and FLS were used separately to investigate the behavior of both the synthesized polymer and [Fe] in Sprague Dawley (SD rats, respectively. Because radioactivity of the isotopes was different by β for CLS and γ for FLS, synthesis of the samples had to be separately prepared. Results: The mean particle size of the ULS was 66.1 nm, and the biodistribution of CLS concentrations in various organs, in rank order of magnitude, was liver > kidney > small intestine > other. The biodistribution of FLS concentrations was liver > spleen > lung > other. These rank orders show that synthesized SPION mainly accumulates in the liver. The differences in the distribution were caused by the SPION metabolism. Radiolabeled

  18. Characterization and stability studies of a novel liposomal cyclosporin A prepared using the supercritical fluid method: comparison with the modified conventional Bangham method

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    Karn PR

    2013-01-01

    Full Text Available Pankaj Ranjan Karn,1,3 Wonkyung Cho,1,3 Hee-Jun Park,1,3 Jeong-Sook Park,3 Sung-Joo Hwang1,21Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Yeonsu-gu, Incheon, Republic of Korea; 2College of Pharmacy, Yonsei University, Yeonsu-gu, Incheon, Republic of Korea; 3College of Pharmacy, Chungnam National University, Yuseong-gu, Daejeon, Republic of KoreaAbstract: A novel method to prepare cyclosporin A encapsulated liposomes was introduced using supercritical fluid of carbon dioxide (SCF-CO2 as an antisolvent. To investigate the strength of the newly developed SCF-CO2 method compared with the modified conventional Bangham method, particle size, zeta potential, and polydispersity index (PDI of both liposomal formulations were characterized and compared. In addition, entrapment efficiency (EE and drug loading (DL characteristics were analyzed by reversed-phase high-performance liquid chromatography. Significantly larger particle size and PDI were revealed from the conventional method, while EE (% and DL (% did not exhibit any significant differences. The SCF-CO2 liposomes were found to be relatively smaller, multilamellar, and spherical with a smoother surface as determined by transmission electron microscopy. SCF-CO2 liposomes showed no significant differences in their particle size and PDI after more than 3 months, whereas conventional liposomes exhibited significant changes in their particle size. The initial yield (%, EE (%, and DL (% of SCF-CO2 liposomes and conventional liposomes were 90.98 ± 2.94, 92.20 ± 1.36, 20.99 ± 0.84 and 90.72 ± 2.83, 90.24 ± 1.37, 20.47 ± 0.94, respectively, which changed after 14 weeks to 86.65 ± 0.30, 87.63 ± 0.72, 18.98 ± 0.22 and 75.04 ± 8.80, 84.59 ± 5.13, 15.94 ± 2.80, respectively. Therefore, the newly developed SCF-CO2 method could be a better alternative compared with the conventional method and may provide a promising approach for large-scale production of liposomes

  19. Presenting a mapping method based on fuzzy Logic and TOPSIS multi criteria decision-making methods to detect promising porphyry copper mineralization areas in the east of the Sarcheshmeh copper metallogenic district

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    Shokouh Riahi

    2017-11-01

    through applying the multi-criteria decision-making method. Finally, the selected favorable areas in the metallogenic strip located at the south to the south-east of the Sarcheshmeh porphyry copper deposit are prioritized and introduced for further follow up ground exploration operations. Methodology In order to solve complex decision-making problems like the problem of mapping favorable porphyry copper mineralization zones under great uncertainties, the TOPSIS method is considered as an appropriate approach offering significant simplicity, flexibility and capability (Ataei., 2010. The TOPSIS method is considered to be an efficient method due to having very high accuracy, speed, sensitivity as well as being easy to implement and interpret the outputted results (Hwang and Yoon, 1981. It has found many applications in important areas of mining industry where there is a need to make decisions under risky conditions and data uncertainties. One basic issue in applying decision-making methods in the field of mineral exploration is to rank and propose the best possible candidates among all potentially favorable areas for the next stage of mineral exploration. In this regard, the best favorable areas are selected based on exploratory data layers including favorable lithologies, alterations, structures plus geochemical and geophysical anomalies (Pazand et al., 2012. Results and discussion In the first step, the area located south to the southeast of one the largest porphyry copper deposits in Iran known as Sarcheshmeh was investigated for favorable areas using all available exploratory data as mentioned in the previous section using fuzzy logic integration approach in the GIS environment. Evaluating the highly favorable areas presented by the fuzzy logic approach showed great consistency with the already known copper mineralization prospects. Next, the first 20 priorities obtained from the fuzzy logic approach were chosen as the best candidates to be ranked using the TOPSIS multi

  20. Effectiveness of professional oral health care intervention on the oral health of residents with dementia in residential aged care facilities: a systematic review protocol.

    Science.gov (United States)

    Yi Mohammadi, Joanna Jin; Franks, Kay; Hines, Sonia

    2015-10-01

    aged care facilities, with the model of care involving dental hygienists/oral health therapists having merit.The concept of professional oral care involves an oral health professional such as a dental hygienist or oral health therapist supervising or assisting residents with their oral care. Oral care involves the mechanical removal of plaque and food debris using a toothbrush, interproximal brush and floss.In 2014, Morino et al. explored the efficacy of short term professional oral care from dental hygienists once a week after breakfast for one month. In this study, the dental hygienists did not perform dental scaling but brushed subjects' teeth using a toothbrush and interdental brush. Dental plaque scores decreased significantly (Fisher's two-tailed tests, peffects of this short term intervention were sustained for the following three months (Wilcoxon test, pfacility using the Oral Health Assessment Tool (OHAT) and Geriatric Oral Health Assessment Index (GOHAI) scores to measure oral health. The results from this study showed improvements in three measured areas (tongue health, denture status and oral cleanliness) in the dental hygiene champion group. These findings suggest that the presence of a dental hygiene champion in long term care facilities may positively impact the oral health of residents requiring assistance with their oral care. However, the authors noted further research in this concept is required.Van Der Putten GJ et al. explored the effectiveness of a supervised implementation of an oral health care guideline in care homes. In each ward of the care homes, a nurse who acted as the ward oral health care organiser (WOO) was appointed. The dental hygienist and an investigator would attend the RACFs every six weeks to support them. The dental hygienist would train the WOO, and the WOO would train the ward nurses and nurse assistants. Participants were allocated into an intervention or a control group. The intervention group received supervised oral care

  1. Characteristics of stable chronic obstructive pulmonary disease patients in the pulmonology clinics of seven Asian cities

    Directory of Open Access Journals (Sweden)

    Oh YM

    2013-01-01

    Full Text Available Yeon-Mok Oh,1 Arvind B Bhome,2 Watchara Boonsawat,3 Kirthi Dias Gunasekera,4 Dushantha Madegedara,5 Luisito Idolor,6 Camilo Roa,6 Woo Jin Kim,7 Han-Pin Kuo,8 Chun-Hua Wang,8 Le Thi Tuyet Lan,9 Li-Cher Loh,10 Choo-Khoon Ong,10 Alan Ng,11 Masaharu Nishimura,12 Hironi Makita,12 Edwin K Silverman,13 Jae Seung Lee,1 Ting Yang,14 Yingxiang Lin,14 Chen Wang,14 Sang-Do Lee1  1Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 2Department of Pulmonary and Critical Care, "Friends of the Breathless" Foundation, Pune, India; 3Department of Medicine, Khon Kaen University, Khon Kaen, Thailand; 4Central Chest Clinic, Colombo and National Hospital of Sri Lanka; 5Respiratory Disease Treatment Unit and Teaching Hospital Kandy, Sri Lanka; 6Section of Respiratory Services and Physical Therapy and Rehabilitation Lung Center of the Philippines, Quezon City, Philippines; 7Department of Internal Medicine, Kangwon National University, Kang Won, Korea; 8Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan; 9Respiratory Care Center, University Medical Center Ho Chi Minh City, Vietnam; 10Department of Medicine, Penang Medical College, Penang, Malaysia; 11Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore; 12Division of Respiratory Medicine, Department of Internal Medicine, Hokkaido University Hospital, Sapporo, Japan; 13Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; 14Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaAll authors made an equal contribution to this studyBackground and objectives: Chronic obstructive pulmonary disease (COPD is responsible for significant morbidity and mortality worldwide. We evaluated the characteristics of stable COPD patients in

  2. SOHO-Ulysses Coordinated Studies During the Two Extended Quadratures and the Alignment of 2007-2008

    Science.gov (United States)

    Suess, S. T.; Poletto, G.

    2007-01-01

    us to study the variation of element abundances across streamer borders in the corona and,correspondingly, "in situ". Also, observing plasma over prolonged time intervals and at different latitudes, we may examine the latitude variation of the fractionation effect (e.g. Yon Steiger, 2002) and its dependence on time (e.g. Woo, 2004). For instance, if the FIP bias is dictated by the duration of plasma confinement in solar loops, its value in streamers should depend on the streamer age. Analogous variations should be found in the abundances of "in situ" plasma released by the streamer. All Ulysses and SOHO data is in the public domain and accessible so different objectives could be addressed by others. The winter 2008 quadrature will be well into the next sunspot cycle and there might be significant high mid-latitude activity. Ulysses will be up to 80 degrees in the northern hemisphere at this time and able to detect the resulting ICMEs and ejecta, allowing us to study the physical parameters of the propagating CME bubble/core/front, and/or to study the coronal and "in situ" characteristics of the current sheet associated with the event (e.g. Bemporad et al. 2005), so far still vaguely defined.

  3. Comparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet

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    Park SI

    2018-04-01

    Full Text Available Sang-In Park,1,* Su-Hak Heo,2,3,* Gihwan Kim,2 Seokhoon Chang,2 Keon-Hyoung Song,3 Min-Gul Kim,4 Eun-Heui Jin,5 JaeWoo Kim,5 SeungHwan Lee,1 Jang Hee Hong5,6 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea; 2R&D Center, C.L. Pharm Co., Ltd, Seoul, Republic of Korea; 3Department of Pharmaceutical Engineering, College of Medical Science, Soonchunhyang University, Asan, Republic of Korea; 4Department of Pharmacology, School of Medicine, Chonbuk National University, Jeonju, Republic of Korea; 5Clinical Trials Center, Chungnam National University Hospital, Daejeon, Republic of Korea; 6Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea *These authors contributed equally to this work Background: An orodispersible film (ODF of tadalafil may provide increased convenience for erectile dysfunction (ED patients as compared to conventional tablet formulations. In this study, we aimed to compare the pharmacokinetic, safety, and tolerability profiles of a newly developed ODF formulation of tadalafil to those of a film-coated tablet (FCT of tadalafil.Materials and methods: This study was conducted in healthy male subjects using an open-label, randomized sequence, two-period, two-formulation, single-dose, crossover design. The subjects were randomly assigned to one of two sequences of the two formulations: both the test drug (ODF and the reference drug (FCT contained 20 mg of tadalafil. Blood samples were collected up to 72 h after administration. Plasma concentrations of tadalafil were analyzed using liquid chromatography–tandem mass spectrometry. Geometric mean ratios (GMRs of the ODF to FCT formulations and their 90% CIs for the pharmacokinetic parameters were estimated. Safety and tolerability were assessed throughout the study.Results: Forty healthy male subjects were enrolled, and 36 of these completed the

  4. A 90-day study of sub-chronic oral toxicity of 20 nm positively charged zinc oxide nanoparticles in Sprague Dawley rats

    Directory of Open Access Journals (Sweden)

    Park HS

    2014-12-01

    Full Text Available Hark-Soo Park,1 Seon-Ju Kim,1 Taek-Jin Lee,1 Geon-Yong Kim,1 EunHo Meang,1 Jeong-Sup Hong,1 Su-Hyon Kim,1 Sang-Bum Koh,1 Seung-Guk Hong,1 Yle-Shik Sun,1 Jin Seok Kang,2 Yu-Ri Kim,3 Meyoung-Kon Kim,3 Jayoung Jeong,4 Jong-Kwon Lee,4 Woo-Chan Son,5 Jae-Hak Park61General Toxicology Team, Korea Testing and Research Institute, Seoul, 2Department of Biomedical Laboratory Science, Namseoul University, Cheonan, 3Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, 4National Institute of Food and Drug Safety Evaluation, Seoul, 5Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 6Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, KoreaPurpose: The study reported here was conducted to determine the systemic oral toxicity and to find the no-observed-adverse-effect level of 20 nm positively charged zinc oxide (ZnOSM,20(+ nanoparticles in Sprague Dawley rats for 90 days.Methods: For the 90-day toxicity study, the high dose was set as 500 mg per kg of body weight (mg/kg and the middle and low dose were set to 250 mg/kg and 125 mg/kg, respectively. The rats were held for a 14-day recovery period after the last administration, to observe for the persistence or reduction of any toxic effects. A distributional study was also carried out for the systemic distribution of ZnOSM,20(+ NPs.Results: No rats died during the test period. There were no significant clinical changes due to the test article during the experimental period in functional assessment, body weight, food and water consumption, ophthalmological testing, urine analysis, necropsy findings, or organ weights, but salivation was observed immediately after administration in both sexes. The total red blood cell count was increased, and hematocrit, albumin, mean cell volume, mean cell hemoglobin, and mean cell hemoglobin concentration were decreased significantly compared with

  5. Predicting treatable traits for long-acting bronchodilators in patients with stable COPD

    Directory of Open Access Journals (Sweden)

    Kang J

    2017-12-01

    Full Text Available Jieun Kang,1,* Ki Tae Kim,2,* Ji-Hyun Lee,3 Eun Kyung Kim,3 Tae-Hyung Kim,4 Kwang Ha Yoo,5 Jae Seung Lee,1 Woo Jin Kim,6 Ju Han Kim,2 Yeon-Mok Oh1 1Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 2Seoul National University Biomedical Informatics and Systems Biomedical Informatics Research Center, Division of Biomedical Informatics, Seoul National University College of Medicine, Seoul, 3Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, 4Division of Pulmonology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, 5Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine, Seoul, 6Department of Internal Medicine and Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea *These authors contributed equally to this work Purpose: There is currently no measure to predict a treatability of long-acting β-2 agonist (LABA or long-acting muscarinic antagonist (LAMA in patients with chronic obstructive pulmonary disease (COPD. We aimed to build prediction models for the treatment response to these bronchodilators, in order to determine the most responsive medication for patients with COPD.Methods: We performed a prospective open-label crossover study, in which each long-acting bronchodilator was given in a random order to 65 patients with stable COPD for 4 weeks, with a 4-week washout period in between. We analyzed 14 baseline clinical traits, expression profiles of 31,426 gene transcripts, and damaged-gene scores of 6,464 genes acquired from leukocytes. The gene expression profiles were measured by RNA microarray and the damaged-gene scores were obtained after DNA exome sequencing. Linear regression analyses were performed to build prediction models after using

  6. Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828 formulation and coadministered telmisartan and S-amlodipine in healthy subjects

    Directory of Open Access Journals (Sweden)

    Kang WY

    2018-03-01

    Full Text Available Woo Youl Kang,1,2,* Sook Jin Seong,1,* Boram Ohk,1,2 Mi-Ri Gwon,1,3 Bo Kyung Kim,1,2 Sookie La,4 Hyun-Ju Kim,3 Seungil Cho,1 Young-Ran Yoon,1,2 Dong Heon Yang,5 Hae Won Lee1 1Clinical Trial Center, Kyungpook National University Hospital, Daegu, Republic of Korea; 2Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Kyungpook National University Graduate School, Daegu, Republic of Korea; 3Department of Molecular Medicine, Cell and Matrix Research Institute, Kyungpook National University School of Medicine, Daegu, Republic of Korea; 4Analytical Research Division, Biocore Co Ltd, Seoul, Republic of Korea; 5Division of Cardiology, Department of Internal Medicine, Kyungpook National University School of Medicine & Hospital, Daegu, Republic of Korea *These authors contributed equally to this work Purpose: A new fixed-dose combination (FDC formulation of telmisartan 80 mg and S-amlodipine 5 mg (CKD-828 has been developed to increase convenience (as only one tablet is required per day and improve treatment compliance.Methods: The pharmacokinetic characteristics and tolerability of an FDC of telmisartan and S-amlodipine were compared to those after coadministration of the individual agents in this randomized, open-label, single-dose, two-way, four-period, crossover study. To analyze the telmisartan and S-amlodipine plasma concentrations using a validated liquid chromatography–tandem mass spectrometry method, serial blood samples were collected up to 48 hours post-dose for telmisartan and 144 hours post-dose for S-amlodipine, in each period.Results: Forty-eight healthy subjects were enrolled, and 43 completed the study. The mean peak plasma concentration (Cmax and the area under the plasma concentration–time curve from time 0 to the last measurement (AUC0–t values of telmisartan were 522.29 ng/mL and 2,475.16 ng⋅h/mL for the FDC, and 540.45 ng/mL and 2,559.57 ng⋅h/mL for the individual agents

  7. Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells

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    Kim YW

    2014-02-01

    Full Text Available Yong-Wan Kim,1 Eun Young Kim,1 Doin Jeon,1 Juinn-Lin Liu,2 Helena Suhyun Kim,3 Jin Woo Choi,4 Woong Shick Ahn5 1Cancer Research Institute of Medical Science, The Catholic University of Korea, Seoul, Republic of Korea; 2Brain Tumor Center, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, TX, USA; 3Cancer Rehab Laboratory, RH Healthcare Systems Inc, TX, USA; 4Harvard Medical School and Wellman Center for Photomedicine, Cambridge, MA, USA; 5Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Republic of Korea Abstract: Paclitaxel (Taxol resistance remains a major obstacle for the successful treatment of ovarian cancer. MicroRNAs (miRNAs have oncogenic and tumor suppressor activity and are associated with poor prognosis phenotypes. miRNA screenings for this drug resistance are needed to estimate the prognosis of the disease and find better drug targets. miRNAs that were differentially expressed in Taxol-resistant ovarian cancer cells, compared with Taxol-sensitive cells, were screened by Illumina Human MicroRNA Expression BeadChips. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR was used to identify target genes of selected miRNAs. Kaplan–Meier survival analysis was applied to identify dysregulated miRNAs in ovarian cancer patients using data from The Cancer Genome Atlas. A total of 82 miRNAs were identified in ovarian carcinoma cells compared to normal ovarian cells. miR-141, miR-106a, miR-200c, miR-96, and miR-378 were overexpressed, and miR-411, miR-432, miR-494, miR-409-3p, and miR-655 were underexpressed in ovarian cancer cells. Seventeen miRNAs were overexpressed in Taxol-resistant cells, including miR-663, miR-622, and HS_188. Underexpressed miRNAs in Taxol-sensitive cells included miR-497, miR-187, miR-195, and miR-107. We further showed miR-663 and miR-622 as significant prognosis markers of the chemo-resistant patient group. In particular, the

  8. Investigation and analysis of oncologists' knowledge of morphine usage in cancer pain treatment

    Directory of Open Access Journals (Sweden)

    Liu W

    2014-05-01

    Full Text Available Weiran Liu,1,* Shumin Xie,2,* Lin Yue,3,* Jiahao Liu,2 Stephanie Mu-Lian Woo,4 Weilin Liu,2 Adam R Miller,5 Jing Zhang,6 Lijun Huang,7 Lei Zhang8,*1Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Anesthesia, Tianjin, People's Republic of China; 2The Xiangya Medical School of Central-South University, Changsha, People's Republic of China; 3Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Outpatient Service, Tianjin, People's Republic of China; 4Harvard University, Cambridge, MA, USA; 5Indiana University School of Medicine, Indianapolis, IN, USA; 6Tianjin Medical University, Tianjin, People's Republic of China; 7Hunan Provincial Tumor Hospital, Department of Lymphoma and Hematology, Changsha, People's Republic of China; 8Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Department of Thoracic Surgery, Tianjin, People's Republic of China *These authors contributed equally to this paperPurpose: To examine oncologists' knowledge of cancer pain and morphine's clinical application in the People's Republic of China. In addition, this study analyzes and discusses the negative factors that currently affect the clinical application of morphine.Patients and methods: A questionnaire survey was given to a random sample of 150 oncologists from Tianjin Medical University Cancer Institute and Hospital. The statistical results were analyzed and processed using SPSS version 21.0 and Matlab version 2012a statistical software. Single-factor analysis of variance, Kruskal–Wallis nonparametric test, and independent samples t-test were adopted to analyze the difference in knowledge scores of morphine usage. The study

  9. Korean Medication Algorithm Project for Bipolar Disorder: third revision

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    Woo YS

    2015-02-01

    Full Text Available Young Sup Woo,1 Jung Goo Lee,2,3 Jong-Hyun Jeong,1 Moon-Doo Kim,4 Inki Sohn,5 Se-Hoon Shim,6 Duk-In Jon,7 Jeong Seok Seo,8 Young-Chul Shin,9 Kyung Joon Min,10 Bo-Hyun Yoon,11 Won-Myong Bahk1 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 2Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, South Korea;3Paik Institute for Clinical Research, Inje Univeristy, Busan, South Korea; 4Department of Psychiatry, Jeju National University Hospital, Jeju, South Korea; 5Department of Psychiatry, Keyo Hospital, Keyo Medical Foundation, Uiwang, South Korea; 6Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Soonchunhyang University, Cheonan, South Korea; 7Department of Psychiatry, Sacred Heart Hospital, Hallym University, Anyang, South Korea; 8Department of Psychiatry, School of Medicine, Konkuk University, Chungju, South Korea; 9Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, South Korea; 10Department of Psychiatry, College of Medicine, Chung-Ang University, Seoul, South Korea; 11Department of Psychiatry, Naju National Hospital, Naju, South Korea Objective: To constitute the third revision of the guidelines for the treatment of bipolar disorder issued by the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP 2014. Methods: A 56-item questionnaire was used to obtain the consensus of experts regarding pharmacological treatment strategies for the various phases of bipolar disorder and for special populations. The review committee included 110 Korean psychiatrists and 38 experts for child and adolescent psychiatry. Of the committee members, 64 general psychiatrists and 23 child and adolescent psychiatrists responded to the survey. Results: The treatment of choice (TOC for euphoric, mixed, and psychotic mania was the combination of a mood stabilizer (MS and an atypical antipsychotic (AAP; the TOC for

  10. Biological test methods for the ecotoxicological characterization of wastes. Final report; Biologische Testerverfahren zur oekotoxikologischen Charakterisierung von Abfaellen. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Roland [Bundesanstalt fuer Materialforschung, Berlin (Germany); Donnevert, Gerhild [Fachhochschule Giessen-Friedberg (Germany). FB MNI; Roembke, Joerg [ECT Oekotoxikologie GmbH, Floersheim am Main (Germany)

    2007-11-15

    battery the acceptance rate varied between 74.1% (Algae test) and 92.6% (Daphnia test). Methodologically, no problems occurred but further guidance on moisture determination in the terrestrial tests as well as details concerning reference testing and data evaluation for several tests are needed. Independently which test system is considered, SOI always caused the lowest effects and WOO was most toxic, while the EC50 values of INC show an intermediate toxicity. Among the aquatic tests, daphnids and one algal species were the most sensitive ones, while plants were always more sensitive than earthworms in the solid waste samples. Based on the test results from additional tests proposals for the modification of the existing basic test battery could be made. For example, the earthworm acute test could be replaced by another soil invertebrate test with higher sensitivity. Further work performed in parallel to the ring test improves waste testing considerably (e.g. the use of artificial soil as control substrate). A comparison of the ring test results with literature data published so far revealed a good agreement. The results of this ring test support confirm that a combination of a battery of biological tests and chemical residue analysis is needed for an ecotoxicological characterization of wastes. With small modifications proposed in this report the basic test battery is considered to be well suitable for the hazard and risk assessment of wastes. Further, probably multi-variate evaluation of the ring test results will improve the identification of those tests most qualified for the ecotoxicological characterization of wastes. Finally, the experiences made in the ring test support also the proposals made in CEN guideline 14735 (2005) concerning the performance of such tests. (orig.)

  11. Volcanic risk metrics at Mt Ruapehu, New Zealand: some background to a probabilistic eruption forecasting scheme and a cost/benefit analysis at an open conduit volcano

    Science.gov (United States)

    Jolly, Gill; Sandri, Laura; Lindsay, Jan; Scott, Brad; Sherburn, Steve; Jolly, Art; Fournier, Nico; Keys, Harry; Marzocchi, Warner

    2010-05-01

    setting up BET_EF for Mt Ruapehu we are forced to define quantitatively what the background activity is. This will result in a quantitative evaluation of what changes in long time monitored parameters may influence the probability of future eruptions. The slopes of Mt Ruapehu host the largest ski area in North Island, New Zealand. Lahars have been generated as a result of several eruptions in the last 50 years, and some of these have reached the ski runs in a very short time frame (around 90 seconds from the beginning of the eruption). In the light of these potentially hazardous lahars, we use the output probabilities provided by BET_EF in a practical and rational decision scheme recently proposed by Marzocchi and Woo (2009) based on a cost/benefit analysis (CBA). In such scheme, a C/L ratio is computed, based on the costs (C) of practical mitigation actions to reduce risk (e.g., a public warning scheme and other means of raising awareness, and a call for a temporary and/or partial closure of the ski area) and on the potential loss (L) if no mitigation action is taken and an eruption occurs causing lahars down the ski fields. By comparing the probability of eruption-driven lahars and the C/L ratio, it is possible to define the most rational mitigation actions that can be taken to reduce the risk to skiers, snowboarders and staff on skifield. As BET_EF probability of eruption changes dynamically as updated monitoring data are received, the authorities can decide, at any specific point in time, what is the best action according to the current monitoring of the volcano. In this respect, CBA represents a bridge linking scientific output (probabilities) and Decision Makers (practical mitigation actions).

  12. The NDH diplomacy

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    Trifković Srđa

    2016-01-01

    Full Text Available The Belgrade coup of 27 March 1941 forced Hitler to improvize the post-Yugoslav political arrangements, as in the preceding years he had sought to woo, rather than destroy, the Kingdom. For his part, just before the Axis attack Mussolini reactivated the leader of ustaša émigrés Ante Pavelić and obtained his reaffirmation of earlier commitments to cede Dalmatia to Italy. Hitler accepted the ustaša 'solution,' whereby his strategy was to let the Italians make enemies of Croats by annexationist policy, and at the same time to encourage Pavelić to terrorize the Serbs. His stratagem resulted in the chronic weakness of the occupation system. Italy did not secure longterm control over the Independent State of Croatia (NDH. Latent antra-Axis tensions provided Pavelić with the room to maneuver between Rome and Berlin and to secure a degree of autonomous action for himself - primarily in his radical attempt to solve the 'Serb question' and in the economic sphere. The NDH diplomatic apparatus reflected the ustaša power structure and the character of the state. Reports from missions abroad were sent mostly ad hoc and they were devoid of attempts to draw analytical conclusions from the news. They were invariably imbued with ungrounded optimism until the very end, likely because of the reluctance to present inferences which the political leaders would not be pleased to hear. Available archives do not indicate how the decisions affecting the NDH foreign relations were formulated; they were probably made by Pavelić and verbally conveyed to the minister. The areas of activity of the foreign ministry were twofold: consular work and the maintenance of routine relations with the Axis powers and their satellites. The consulates in the Reich were mainly dealing with the workers from the NDH in Germany, and they were actively discriminating against the Serbs who were issued one-way travel passes which prevented their return to Germany. After the fall of Italy

  13. A new inventory for two-wheel vehicle emissions in West Africa for 2002

    Science.gov (United States)

    Assamoi, Eric-Michel; Liousse, Catherine

    2010-10-01

    Rather surprisingly, urban atmospheric particulate levels in West Africa compare with measured concentrations in Europe and Asia megacities (Liousse, C., Galy-Lacaux, C., Assamoi, E.-M., Ndiaye, A., Diop, B., Cachier, H., Doumbia, T., Gueye, P., Yoboue, V., Lacaux, J.-P., Guinot, B., Guillaume, B., Rosset, R., Castera, P., Gardrat, E., Zouiten, C., Jambert, C., Diouf, A., Koita, O., Baeza, A., Annesi-Maesano, I., Didier, A., Audry, S., Konare, A., 2009. Integrated Focus on West African Cities (Cotonou, Bamako, Dakar, Ouagadougou, Abidjan, Niamey): Emissions, Air Quality and Health Impacts of Gases and Aerosols. Third International AMMA Conference on Predictability of the West African Moosoon Weather, Climate and Impacts. Ouagadougou, Burkina Faso. July 20-24). This pollution mainly derives from road traffic emissions with, in some capitals (e.g. Cotonou), the strong contribution of two-wheel vehicles. Two key questions arise: are presently available emission inventories (e.g. Junker, C., Liousse, C., 2008. A global emission inventory of carbonaceous aerosol from historic records of fossil fuel and biofuel consumption for the period 1860-1997. Atmospheric Chemistry Physics, 8, 1-13; Bond, T.C., Streets, D.G., Yarber, K.F., Nelson, S.M., Woo, J.H., Klimont, Z., 2004. A technology-based global inventory of black and organic carbon emissions from combustion. Journal of Geophysical Research, 1009, D14203, DOI:10.1029/2003JD003697) able to account for these emissions? And, if not, how can we remedy this? The aim of this paper is to develop a methodology to estimate emissions produced by two-wheel vehicles in West Africa for 2002 in a context where reliable information is hardly available. Fuel consumption ratios between two-wheel engines (in this work) and all vehicles issued from UN database ( http://data.un.org/Data.aspx?d=EDATA&f=cmID%3aMO%3btrID%3a1221) are as high as 169%, 264% and 628%, for Burkina Faso, Mali and Chad respectively, indicating that this global

  14. Combining probabilistic hazard assessment with cost-benefit analysis to support decision making in a volcanic crisis from the Auckland Volcanic Field, New Zealand

    Science.gov (United States)

    Sandri, Laura; Jolly, Gill; Lindsay, Jan; Howe, Tracy; Marzocchi, Warner

    2010-05-01

    One of the main challenges of modern volcanology is to provide the public with robust and useful information for decision-making in land-use planning and in emergency management. From the scientific point of view, this translates into reliable and quantitative long- and short-term volcanic hazard assessment and eruption forecasting. Because of the complexity in characterizing volcanic events, and of the natural variability of volcanic processes, a probabilistic approach is more suitable than deterministic modeling. In recent years, two probabilistic codes have been developed for quantitative short- and long-term eruption forecasting (BET_EF) and volcanic hazard assessment (BET_VH). Both of them are based on a Bayesian Event Tree, in which volcanic events are seen as a chain of logical steps of increasing detail. At each node of the tree, the probability is computed by taking into account different sources of information, such as geological and volcanological models, past occurrences, expert opinion and numerical modeling of volcanic phenomena. Since it is a Bayesian tool, the output probability is not a single number, but a probability distribution accounting for aleatory and epistemic uncertainty. In this study, we apply BET_VH in order to quantify the long-term volcanic hazard due to base surge invasion in the region around Auckland, New Zealand's most populous city. Here, small basaltic eruptions from monogenetic cones pose a considerable risk to the city in case of phreatomagmatic activity: evidence for base surges are not uncommon in deposits from past events. Currently, we are particularly focussing on the scenario simulated during Exercise Ruaumoko, a national disaster exercise based on the build-up to an eruption in the Auckland Volcanic Field. Based on recent papers by Marzocchi and Woo, we suggest a possible quantitative strategy to link probabilistic scientific output and Boolean decision making. It is based on cost-benefit analysis, in which all costs

  15. Hydrochemical Characteristics of Groundwater in an Agricultural Area in South Korea

    Science.gov (United States)

    Kim, N.; Hamm, S.; An, J.; Lee, J.; Jang, S.

    2008-12-01

    The study area, Sacheon-Hadong area, is located in the southern part of the Korean peninsula, which is bounded by the South Sea and surrounded by the Seomjin River in the west. The study area utilized for agricultural work for a long time. That resulted in vulnerable situation of groundwater due to contamination by fertilizer, insecticide and other human activities. In addition, groundwater is in the risk of seawater intrusion because of the study area's location nearby the South Sea. In Sacheon and Hadong area, the EC values were higher in alluvial aquifer than bedrock aquifer. The higher EC values in the alluvial groundwater than the bedrock groundwater were influenced by agricultural activity in near-surface. Water types of two groundwaters belong to Ca-Cl and Na-Cl types due to saline-water influence. EC values are raised, becoming close to the coast. The correlation analysis showed that EC had positive relationship with Na+, Ca2+, Mg2+, Fe2+, Mn2+, SO42-, and Cl-, indicating mixing with seawater. In Sacheon area, nitrogen isotope ratios in the alluvial groundwater ranged between -0.40 and 12.80‰, with 0.05~2.49 mg/l of NO3-N concentration; the range of nitrogen isotopes in the bedrock groundwater was between 3.30 and 17.60‰, with 0.12~2.14 mg/l of NO3-N concentration. Nitrogen was originated from organic source in soils, manures, and domestic wastes (Mueller and Helsel, 1996; Kim and Woo, 2003). In Hadong area, the nitrogen isotopes in the alluvial groundwater ranged from -0.50 to 19.10‰, and NO3-N concentration was between 0.63 and 6.68 mg/l. And these may be originated from anthropogenic pollutants (Mueller and Helsel, 1996). In Sacheon area, average δ18O and δD in alluvial groundwater were analyzed as - 6.77‰ and -47.50‰; average isotope ratios in bedrock groundwater were -7.73‰ and - 53.46‰. In Hadong area, average δ18O and δD in the alluvial groundwater were - 7.32‰ and -49.80‰; average isotope ratios in the bedrock groundwater

  16. Comparison of World Health Organization and Asia-Pacific body mass index classifications in COPD patients

    Directory of Open Access Journals (Sweden)

    Lim JU

    2017-08-01

    Full Text Available Jeong Uk Lim,1 Jae Ha Lee,2 Ju Sang Kim,3 Yong Il Hwang,4 Tae-Hyung Kim,5 Seong Yong Lim,6 Kwang Ha Yoo,7 Ki-Suck Jung,4 Young Kyoon Kim,8 Chin Kook Rhee8 1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, 2Division of Pulmonology, Department of Internal Medicine, Inje University College of Medicine, Haeundae Paik Hospital, Busan, 3Division of Pulmonary Medicine, Department of Internal Medicine, Incheon St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, 4Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, 5Division of Pulmonary and Critical Care Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, 6Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 7Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, 8Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea Introduction: A low body mass index (BMI is associated with increased mortality and low health-related quality of life in patients with COPD. The Asia-Pacific classification of BMI has a lower cutoff for overweight and obese categories compared to the World Health Organization (WHO classification. The present study assessed patients with COPD among different BMI categories according to two BMI classification systems: WHO and Asia-Pacific. Patients and methods: Patients with COPD aged 40 years or older from the Korean COPD Subtype Study cohort were selected for evaluation

  17. Social Media Impact of the Food and Drug Administration's Drug Safety Communication Messaging About Zolpidem: Mixed-Methods Analysis.

    Science.gov (United States)

    Sinha, Michael S; Freifeld, Clark C; Brownstein, John S; Donneyong, Macarius M; Rausch, Paula; Lappin, Brian M; Zhou, Esther H; Dal Pan, Gerald J; Pawar, Ajinkya M; Hwang, Thomas J; Avorn, Jerry; Kesselheim, Aaron S

    2018-01-05

    first DSC. ITS analyses demonstrated variability but pointed to an increase in interest around the first DSC. Chow tests were significant (PSocial media offers challenges and opportunities for dissemination of the DSC messages. The FDA could consider strategies for more actively disseminating DSC safety information through social media platforms, particularly when announcements require updating. The FDA may also benefit from directly contributing content to websites like Wikipedia that are frequently accessed for drug-related information. ©Michael S Sinha, Clark C Freifeld, John S Brownstein, Macarius M Donneyong, Paula Rausch, Brian M Lappin, Esther H Zhou, Gerald J Dal Pan, Ajinkya M Pawar, Thomas J Hwang, Jerry Avorn, Aaron S Kesselheim. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 05.01.2018.

  18. A Web-Based Graphical Food Frequency Assessment System: Design, Development and Usability Metrics.

    Science.gov (United States)

    Franco, Rodrigo Zenun; Alawadhi, Balqees; Fallaize, Rosalind; Lovegrove, Julie A; Hwang, Faustina

    2017-05-08

    score (n=141) was 75.0 (interquartile range [IQR] 12.5), and 84% of the participants who completed the SUS classified the system either "good" (n=50) or "excellent" (n=69). Considering only participants using smartphones or tablets (n=80), the median score was 72.5 (IQR 12.5), slightly below the SUS median for desktops and laptops (n=58), which was 75.0 (IQR 12.5). No significant differences were found between genders or age groups (below and above the median) for the SUS or completion time. Taking into account all the requirements, the deployment used professional cloud computing at no cost, and the resulting system had good user acceptance. The results for smartphones/tablets were comparable with desktops/laptops. This work has potential to promote wider uptake of online tools that can assess dietary intake at scale. ©Rodrigo Zenun Franco, Balqees Alawadhi, Rosalind Fallaize, Julie A Lovegrove, Faustina Hwang. Originally published in JMIR Human Factors (http://humanfactors.jmir.org), 08.05.2017.

  19. Combination therapy of inhaled steroids and long-acting beta2-agonists in asthma–COPD overlap syndrome

    Directory of Open Access Journals (Sweden)

    Lee SY

    2016-11-01

    Full Text Available Suh-Young Lee,1,* Hye Yun Park,2,* Eun Kyung Kim,3 Seong Yong Lim,4 Chin Kook Rhee,5 Yong Il Hwang,6 Yeon-Mok Oh,7 Sang Do Lee,7 Yong Bum Park1 On behalf of the KOLD Study Group 1Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 3Department of Internal Medicine, Bundang CHA Medical Center, CHA University College of Medicine, Seongnam, 4Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 5Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 6Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University Medical School, Gyeonggido, 7Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Ulsan, Republic of Korea *These authors contributed equally to this work Background: The efficacy of inhaled corticosteroids (ICSs/long-acting beta2-agonist (LABA treatment in patients with asthma–chronic obstructive pulmonary disease (COPD overlap syndrome (ACOS compared to patients with COPD alone has rarely been examined. This study aimed to evaluate the clinical efficacy for the improvement of lung function after ICS/LABA treatment in patients with ACOS compared to COPD alone patients. Methods: Patients with stable COPD were selected from the Korean Obstructive Lung Disease (KOLD cohort. Subjects began a 3-month ICS/LABA treatment after a washout period. ACOS was defined when the patients had 1 a personal history of asthma, irrespective of age, and wheezing in the last 12 months in a self-reported survey

  20. A novel HVSR approach on structural heath monitoring for structural vulnerability assesement

    Science.gov (United States)

    Pentaris, Fragkiskos P.; Papadopoulos, Ilias

    2014-05-01

    of Education of Greece and the European Union in the framework of the project entitled «Interdisciplinary Multi-Scale Research of Earthquake Physics and Seismotectonics at the front of the Hellenic Arc (IMPACT-ARC) ». References [1] F. P. Pentaris, J. Stonham, and J. P. Makris, "A review of the state-of-the-art of wireless SHM systems and an experimental set-up towards an improved design," presented at the EUROCON, 2013 IEEE, Zagreb, 2013. [2] R. Ditommaso, M. Mucciarelli, S. Parolai, and M. Picozzi, "Monitoring the structural dynamic response of a masonry tower: Comparing classical and time-frequency analyses," Bulletin of Earthquake Engineering, vol. 10, pp. 1221-1235, 2012. [3] Sungkono, D. D. Warnana, Triwulan, and W. Utama, "Evaluation of Buildings Strength from Microtremor Analyses " International Journal of Civil & Environmental Engineering IJCEE-IJENS, vol. 11, 2011. [4] L.-L. Hong and W.-L. Hwang, "Empirical formula for fundamental vibration periods of reinforced concrete buildings in Taiwan," Earthquake Engineering & Structural Dynamics, vol. 29, pp. 327-337, 2000.

  1. Use of blood biomarkers to screen for obstructive sleep apnea

    Directory of Open Access Journals (Sweden)

    Fleming WE

    2018-06-01

    Full Text Available Wesley Elon Fleming,1 Jon-Erik C Holty,2 Richard K Bogan,3 Dennis Hwang,4 Aliya S Ferouz-Colborn,4 Rohit Budhiraja,5 Susan Redline,5 Edith Mensah-Osman,6 Nadir Ishag Osman,6 Qing Li,7 Armaghan Azad,1 Susann Podolak,1 Michael K Samoszuk,8 Amabelle B Cruz,8 Yang Bai,8 Jiuliu Lu,8 John S Riley,8 Paula C Southwick8 1Sleep Center Orange County, Irvine, CA, USA; 2Stanford Medical School, VA Palo Alto Health Care System, Pulmonary, Critical Care and Sleep Medicine Section, Palo Alto, CA, USA; 3SleepMed Inc., Bogan Sleep Consultants, LLC, Columbia, SC, USA; 4Sleep Medicine Department, Southern California Permanente Medical Group, Kaiser Permanente, Fontana Medical Center, Fontana, CA, USA; 5Division of Sleep Medicine, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA; 6EENA Comprehensive Neurology and Sleep Center, Boynton Beach, FL, USA; 7South Bend Medical Foundation, New Technology and Test Development, South Bend, IN, USA; 8Clinical Research Department, Beckman Coulter, Inc., Brea, CA, USAPurpose: Obstructive sleep apnea (OSA is a highly prevalent disorder associated with increased risk for cardiovascular disease, diabetes, and other chronic conditions. Unfortunately, up to 90% of individuals with OSA remain without a diagnosis or therapy. We assess the relationship between OSA and blood biomarkers, and test the hypothesis that combinations of markers provide a characteristic OSA signature with diagnostic screening value. This validation study was conducted in an independent cohort in order to replicate findings from a prior feasibility study.Patients and methods: This multicenter prospective study consecutively enrolled adult male subjects with clinically suspected OSA. All subjects underwent overnight sleep studies. An asymptomatic control group was also obtained. Five biomarkers were tested: glycated hemoglobin (HbA1c, C-reactive protein (CRP, uric acid, erythropoietin (EPO, and interleukin-6 (IL-6.Results: The study

  2. Boron diffusion in strained and strain-relaxed SiGe

    International Nuclear Information System (INIS)

    Wang, C.C.; Sheu, Y.M.; Liu, Sally; Duffy, R.; Heringa, A.; Cowern, N.E.B.; Griffin, P.B.

    2005-01-01

    SiGe has been utilized for aggressive CMOS technologies development recently and there are many references [M. Shima, T. Ueno, T. Kumise, H. Shido, Y. Sakuma, S. Nakamura, Symposium on VLSI Technology Technical Digest, 2002, pp. 94-95; T. Ghani, M. Armstrong, C. Auth, M. Bost, P. Charvat, G. Glass, T. Hoffmann, K. Johnson, C. Kenyon, J. Klaus, B. McIntyre, K. Mistry, A. Murthy, J. Sandford, M. Silberstein, S. Sivakumar, P. Smith, K. Zawadzki, S. Thompson, M. Bohr, International Electron Devices Meeting Technical Digest, December 2003, pp. 978-980; P. Bai, C. Auth, S. Balakrishnan, M. Bost, R. Brain, V. Chikarmane, R. Heussner, M. Hussein, J. Hwang, D. Ingerly, R. James, J. Jeong, C. Kenyon, E. Lee, S. Lee, N. Lindert, M. Liu, Z. Ma, T. Marieb, A. Murthy, R. Nagisetty, S. Natarajan, J. Neirynck, A. Ott, C. Parker, J. Sebastian, R. Shaheed, S. Sivakumar, J. Steigerwald, S. Tyagi, C. Weber, B. Woolery, A. Yeoh, K. Zhang, M. Bohr, International Electron Devices Meeting Technical Digest, December 2004, pp. 657-660] presenting the advantages brought by it. A better understanding regarding the boron diffusion behavior within and in the vicinity of SiGe is necessary to optimize the extension and the source/drain in pMOSFET. In order to achieve the goal, both effects from mechanical strain and Ge doping on boron diffusion have been investigated. However, only a few publications discuss the impacts of both. Furthermore, most researches investigate these two effects under the conditions of low boron concentration [P. Kuo, J.L. Hoyt, J.F. Gibbons, J.E. Turner, D. Lefforge, Appl. Phys. Lett. 66 (January (5)) (1995) 580-582; N.R. Zangenberg, J. Fage-Pedersen, J. Lundsgaard Hansen, A. Nylandsted Larsen, J. Appl. Phys. 94 (September (6)) (2003) 3883-3890] and high thermal budget anneal [P. Kuo, J.L. Hoyt, J.F. Gibbons, J.E. Turner, D. Lefforge, Appl. Phys. Lett. 66 (January (5)) (1995) 580-582; N.R. Zangenberg, J. Fage-Pedersen, J. Lundsgaard Hansen, A. Nylandsted Larsen, J. Appl

  3. Development and Validation of a Multidisciplinary Mobile Care System for Patients With Advanced Gastrointestinal Cancer: Interventional Observation Study.

    Science.gov (United States)

    Soh, Ji Yeong; Cha, Won Chul; Chang, Dong Kyung; Hwang, Ji Hye; Kim, Kihyung; Rha, Miyong; Kwon, Hee

    2018-05-07

    dropped out, the most common reason was the change of patient's clinical condition (51.9%). During the study period, subjects received multiple health education sessions. For the gastric cancer group, the "general gastric cancer education" was most frequently viewed (322 times), and for the colon cancer group, the "warming-up exercise" was most viewed (340 times). Of 13 measurements taken from subjects, 9 were taken offline (response rate: 52.0% to 90.1%), and 3 were taken online (response rate: 17.6% to 57.4%). The overall satisfaction rate among subjects was favorable and ranged from 3.93 (SD 0.88) to 4.01 (SD 0.87) on the 5-point Likert scale. A multidisciplinary mobile care system for patients with advanced gastrointestinal cancer was developed with clinically oriented measures. A prospective study was performed for its evaluation, which showed favorable satisfaction. ©Ji Yeong Soh, Won Chul Cha, Dong Kyung Chang, Ji Hye Hwang, Kihyung Kim, Miyong Rha, Hee Kwon. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 07.05.2018.

  4. Profound vision loss impairs psychological well-being in young and middle-aged individuals

    Directory of Open Access Journals (Sweden)

    Garcia GA

    2017-02-01

    Full Text Available Giancarlo A Garcia,1,2 Matin Khoshnevis,1,3 Jesse Gale,1,4 Starleen E Frousiakis,1,5 Tiffany J Hwang,1,6 Lissa Poincenot,1 Rustum Karanjia,1,7–9 David Baron,6 Alfredo A Sadun1,7 1Doheny Eye Institute, Los Angeles, CA, USA; 2University of California, Irvine School of Medicine, Irvine, CA, USA; 3Department of Ophthalmology, Temple University, Philadelphia, PA, USA; 4Wellington School of Medicine and Health Sciences, University of Otago, Wellington, NZ; 5Department of Ophthalmology, New York Medical College, Valhalla, NY, USA; 6Department of Psychiatry & The Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; 7Doheny Eye Centers, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles California, CA, USA; 8Department of Ophthalmology, University of Ottawa, Ottawa, ON, Canada; 9Ottawa Hospital Health Research Institute, Ottawa, ON, Canada Purpose: The aim of this study was to evaluate the effects of profound vision loss on psychological well-being in adolescents, young adults, and middle-aged adults with regard to mood, interpersonal interactions, and career-related goals. In addition, we assessed the significance of the resources that may be used to enhance psychological well-being in cases of profound vision loss, and in particular, examined the utility of low vision aids and the role of the ophthalmologist as a provider of emotional support.Methods: A questionnaire was issued to individuals aged 13–65 years with profound vision loss resulting from Leber’s hereditary optic neuropathy (LHON. Depression prevalence was evaluated with questions regarding major depressive disorder symptomatology. Participants appraised the effects of vision loss on their interpersonal interactions and career goals by providing an impact rating (IR on a 21-point psychometric scale from −10 to +10. Social well-being index was defined as the average of interpersonal IR and career IR

  5. No gynecologist in town: the gynecological care of women in rural Taiwan

    Directory of Open Access Journals (Sweden)

    Lai LJ

    2015-07-01

    Full Text Available Li-Jung Lai,1 Chia-Lin Chou,2 H Irene Su,3 Tzeng-Ji Chen,1,4 Li-Fang Chou,5 Yueh-Ching Chou,2,6,7 Shinn-Jang Hwang,1,8 Hann-Chin Yu9,10 1Department of Family Medicine, 2Department of Pharmacy, Taipei Veterans General Hospital, Taipei, Taiwan; 3Department of Reproductive Medicine, University of California, San Diego, CA, USA; 4Institute of Hospital and Health Care Administration, School of Medicine, National Yang-Ming University, 5Department of Public Finance, National Chengchi University, 6Department and Institute of Pharmacology, National Yang-Ming University, 7College of Pharmacy, Taipei Medical University, 8Department of Family Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 9Taipei Veterans General Hospital Hsinchu Branch, Hsinchu County, Taiwan; 10Department of Healthcare Management, Yuanpei University, Hsinchu, Taiwan Background: A shortage of gynecologists exists in many countries. Even within an affluent country, gynecological clinics might not be evenly distributed. The purpose of the study was to investigate the disparity in gynecological care between adult women living in towns with and without gynecologists in Taiwan.Methods: Data sources were the cohort datasets of the National Health Insurance Research Database, with claims data of 1 million beneficiaries in 2010. A woman’s residency was operationally inferred from the locations where she had most frequently visited physicians’ clinics or local community hospitals within the year.Results: In Taiwan, 145 (39.4% of 368 towns had no practicing gynecologist. Of 382,167 women with health care use in the datasets, 21,794 (5.7% lived in towns without a gynecologist. The overwhelming majority of these towns lay in sparsely populated, rural areas. During the year, 132,702 women (34.7% had sought medical help for gynecological diseases and 113,698 (29.8% had visited gynecologists for gynecological diseases. Women in towns without a gynecologist were less

  6. The complete mitochondrial sequence of the"living fossil" Tricholepidion gertschi: structure, phylogenetic implications, and the description of a novel A/T asymmetrical bias

    Energy Technology Data Exchange (ETDEWEB)

    Nardi, F.; Frati, F.; Carapelli, A.; Dallai, R.; Boore, J.

    2002-06-23

    mitochondrial genome sequences to study the evolution and differentiation of the most basal hexapod groups, including Tricholepidion. Mitochondrial genomics, that is analysis of various features of the mitochondrial genome such as gene order and the analysis of the concatenated sequence of its genes, has proved to be a very powerful tool for the study of ancient phylogenetic relationships (Boore, 2000; Boore and Brown, 1995; Boore and Brown, 1998; Garcia-Machado et al., 1999; Hwang et al., 2001; Nardi et al., 2001), and its application seems to be appropriate for the problem under study ((Nardi et al., 2001), this study). In addition, complete mitochondrial sequences, with the advent of automatic sequencing tools, are accumulating rapidly, but there is a strong bias towards the better known or economically important groups, while only two sequences have been produced for the more basal, and evolutionarily more intriguing, hexapod orders. The complete sequence of the mitochondrial genome of Tricholepidion gertschi is the second among apterygotans, following the collembolan T.bielanensis (Nardi et al., 2001).

  7. Comparative study on medical utilization and costs of chronic obstructive pulmonary disease with good lung function

    Directory of Open Access Journals (Sweden)

    Lim JU

    2017-09-01

    Full Text Available Jeong Uk Lim,1 Kyungjoo Kim,2 Sang Hyun Kim,3 Myung Goo Lee,4 Sang Yeub Lee,5 Kwang Ha Yoo,6 Sang Haak Lee,1 Ki-Suck Jung,7 Chin Kook Rhee,2 Yong Il Hwang7 1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, St Paul’s Hospital, 2Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 3Big Data Division, Health Insurance Review and Assessment Service, Wonju, 4Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, 5Department of Internal Medicine, Korea University, Anam Hospital, 6Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, 7Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, Republic of Korea Introduction: Patients with mild to moderate chronic obstructive pulmonary disease (COPD are underdiagnosed and undertreated due to the asymptomatic nature of the disease. Previous studies on patients with mild COPD have focused on symptomatic patients. Therefore, in this study, we evaluated the treatment status of patients with early COPD in Korea.Materials and methods: We compared hospital visits, medical costs per person, and COPD medication use by patients with COPD screened from the general population and COPD cohort patients. Patients with COPD aged ≥40 years with the value of forced expiratory volume in 1 s (FEV1 ≥60% were selected from the 2007 to 2012 Korea National Health and Nutrition Examination Survey (KNHANES data. Data including the number of outpatient clinic visits, admission to hospitals, COPD-related medications, and medical

  8. Inference of directed climate networks: role of instability of causality estimation methods

    Science.gov (United States)

    Hlinka, Jaroslav; Hartman, David; Vejmelka, Martin; Paluš, Milan

    2013-04-01

    weights in the networks is ~ 0.6. The networks constructed using nonlinear measures were in general less stable both in real data and stationarized surrogates. Interestingly, when the nonlinear method parameters are optimized with respect to temporal stability of the networks, the networks seem to converge close to those detected by linear Granger causality. This provides further evidence for the hypothesis of overall sparsity and weakness of nonlinear coupling in climate networks on this spatial and temporal scale [3] and sufficient support for the use of linear methods in this context, unless specific clearly detectable nonlinear phenomena are targeted. Acknowledgement: This study is supported by the Czech Science Foundation, Project No. P103/11/J068. [1] Boccaletti, S.; Latora, V.; Moreno, Y.; Chavez, M. & Hwang, D. U.: Complex networks: Structure and dynamics, Physics Reports, 2006, 424, 175-308 [2] Barnett, L.; Barrett, A. B. & Seth, A. K.: Granger Causality and Transfer Entropy Are Equivalent for Gaussian Variables, Physical Review Letters, 2009, 103, 238701 [3] Hlinka, J.; Hartman, D.; Vejmelka, M.; Novotná, D.; Paluš, M.: Non-linear dependence and teleconnections in climate data: sources, relevance, nonstationarity, submitted preprint (http://arxiv.org/abs/1211.6688)

  9. Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells

    Directory of Open Access Journals (Sweden)

    Lin JF

    2017-05-01

    Full Text Available Ji-Fan Lin,1 Yi-Chia Lin,2 Te-Fu Tsai,2,3 Hung-En Chen,2 Kuang-Yu Chou,2,3 Thomas I-Sheng Hwang2–4 1Central Laboratory, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, 2Division of Urology, School of Medicine, Fu-Jen Catholic University, New Taipei, 3Division of Urology, Department of Surgery, Shin Kong Wu Ho-Su Memorial Hospital, 4Department of Urology, Taipei Medical University, Taipei, Taiwan Purpose: Cisplatin-based chemotherapy is the first line treatment for several cancers including bladder cancer (BC. Autophagy induction has been implied to contribute to cisplatin resistance in ovarian cancer; and a high basal level of autophagy has been demonstrated in human bladder tumors. Therefore, it is reasonable to speculate that autophagy may account for the failure of cisplatin single treatment in BC. This study investigated whether cisplatin induces autophagy and the mechanism involved using human BC cell lines.Materials and methods: Human BC cells (5637 and T24 were used in this study. Cell viability was detected using water soluble tetrazolium-8 reagents. Autophagy induction was detected by monitoring the levels of light chain 3 (LC3-II and p62 by Western blot, LC3-positive puncta formation by immunofluorescence, and direct observation of the autophagolysosome (AL formation by transmission electron microscopy. Inhibitors including bafilomycin A1 (Baf A1, chloroquine (CQ, and shRNA-based lentivirus against autophagy-related genes (ATG7 and ATG12 were utilized. Apoptosis level was detected by caspase 3/7 activity and DNA fragmentation.Results: Cisplatin decreased cell viability and induced apoptosis of 5637 and T24 cells in a dose- and time-dependent manner. The increased LC3-II accumulation, p62 clearance, the number of LC3-positive puncta, and ALs in cisplatin-treated cells suggested that cisplatin indeed induces autophagy. Inhibition of cisplatin-induced autophagy using Baf A1, CQ, or ATG7/ATG12 shRNAs significantly enhanced cytotoxicity of

  10. Mapping the entangled ontology of science teachers' lived experience

    Science.gov (United States)

    Daugbjerg, Peer S.; de Freitas, Elizabeth; Valero, Paola

    2015-09-01

    In this paper we investigate how the bodily activity of teaching, along with the embodied aspect of lived experience, relates to science teachers' ways of dealing with bodies as living organisms which are both the subject matter as well as the site or vehicle of learning. More precisely, the following questions are pursued: (1) In what ways do primary science teachers refer to the lived and living body in teaching and learning? (2) In what ways do primary science teachers tap into past experiences in which the body figured prominently in order to teach students about living organisms? We draw on the relational ontology and intra-action of Karen Barad (J Women Cult Soc 28(3): 801, 2003) as she argues for a "relational ontology" that sees a relation as a dynamic flowing entanglement of a matter and meaning. We combine this with the materialist phenomenological studies of embodiment by SungWon Hwang and Wolff-Michael Roth (Scientific and mathematical bodies, Sense Publishers, Rotterdam, 2011), as they address how the teachers and students are present in the classroom with/in their "living and lived bodies". Our aim is to use theoretical insights from these two different but complementary approaches to map the embodiment of teachers' experiences and actions. We build our understanding of experience on the work of John Dewey (Experience and education, Simon & Schuster, New York, 1938) and also Jean Clandinin and Michael Connelly (Handbook of qualitative research, Sage Publications, California, 2000), leading us to propose three dimensions: settings, relations and continuity. This means that bodies and settings are mutually entailed in the present relation, and furthermore that the past as well as the present of these bodies and settings—their continuity—is also part of the present relation. We analyse the entanglement of lived experience and embodied teaching using these three proposed dimensions of experience. Analysing interviews and observations of three Danish

  11. Turbulence modeling for mass transfer enhancement by separation and reattachment with two-equation eddy-viscosity models

    International Nuclear Information System (INIS)

    Xiong Jinbiao; Koshizuka, Seiichi; Sakai, Mikio

    2011-01-01

    Highlights: → We selected and evaluated five two-equation eddy-viscosity turbulence models for modeling the separated and reattaching flow. → The behavior of the models in the simple flow is not consistent with that in the separated and reattaching flow. → The Abe-Kondoh-Nagano model is the best one among the selected model. → Application of the stress limiter and the Kato-Launder modification in the Abe-Kondoh-Nagano model helps to improve prediction of the peak mass transfer coefficient in the orifice flow. → The value of turbulent Schmidt number is investigated. - Abstract: The prediction of mass transfer rate is one of the key elements for estimation of the flow accelerated corrosion (FAC) rate. Three low Reynolds number (LRN) k-ε models (Lam-Bremhorst (LB), Abe-Kondoh-Nagano (AKN) and Hwang-Lin (HL)), one LRN k-ω (Wilcox, WX) model and the k-ω SST model are tested for the computation of the high Schmidt number mass transfer, especially in the flow through an orifice. The models are tested in the computation of three types of flow: (1) the fully developed pipe flow, (2) the flow over a backward facing step, (3) the flow through an orifice. The HL model shows a good performance in predicting mass transfer in the fully developed pipe flow but fails to give reliable prediction in the flow through an orifice. The WX model and the k-ω SST model underpredict the mass transfer rate in the flow types 1 and 3. The LB model underestimates the mass transfer in the flow type 1, but shows abnormal behavior at the reattaching point in type 3. Synthetically evaluating all the models in all the computed case, the AKN model is the best one; however, the prediction is still not satisfactory. In the evaluation in the flow over a backward facing step shows k-ω SST model shows superior performance. This is interpreted as an implication that the combination of the k-ε model and the stress limiter can improve the model behavior in the recirculation bubble. Both the

  12. EDITORIAL: Synaptic electronics Synaptic electronics

    Science.gov (United States)

    Demming, Anna; Gimzewski, James K.; Vuillaume, Dominique

    2013-09-01

    integrated memristors Nanotechnology 24 384011 [7] Timm C and Di Ventra M 2013 Molecular neuron based on the Franck-Condon blockade Nanotechnology 24 384001 [8] Sillin H O, Aguilera R, Shieh H-H, Avizienis A V, Aono M, Stieg A Z and Gimzewski J K 2013 A theoretical and experimental study of neuromorphic atomic switch networks for reservoir computing Nanotechnology 24 384004 [9] Linn E, Menzel S, Ferch S and Waser R 2013 Compact modeling of CRS devices based on ECM cells for memory, logic and neuromorphic applications Nanotechnology 24 384008 [10] Konkoli Z and Wendin G 2013 A generic simulator for large networks of memristive elements Nanotechnology 24 384007 [11] Gacem K, Retrouvey J-M, Chabi D, Filoramo A, Zhao W, Klein J-O and Derycke V 2013 Neuromorphic function learning with carbon nanotube-based synapses Nanotechnology 24 384013 [12] Lim H, Kim I, Kim J-S, Hwang C S and Jeong D S 2013 Short-term memory of TiO2-based electrochemical capacitors: empirical analysis with adoption of a sliding threshold Nanotechnology 24 384005 [13] Park S, Noh J, Choo M-L, Sheri A M, Chang M, Kim Y-B, Kim C J, Jeon M, Lee B-G, Lee B H and Hwang H 2013 Nanoscale RRAM-based synaptic electronics: toward a neuromorphic computing device Nanotechnology 24 384009 [14] Yang R, Terabe K, Yao Y, Tsuruoka T, Hasegawa T, Gimzewski J K and Aono M 2013 Synaptic plasticity and memory functions achieved in WO3-x-based nanoionics device by using principle of atomic switch operation Nanotechnology 24 384002 [15] Ambrogio S, Balatti S, Nardi F, Facchinetti S and Ielmini D 2013 Spike-timing dependent plasticity in a transistor-selected resistive switching memory Nanotechnology 24 384012 [16] Indiveria G, Linares-Barranco B, Legenstein R, Deligeorgis G and Prodromakise T 2013 Integration of nanoscale memristor synapses in neuromorphic computing architectures Nanotechnology 24 384010 [17] Hino T, Hasegawa T, Tanaka H, Tsuruoka T, Terabe K, Ogawa T and Aono M 2013 Volatile and nonvolatile selective switching of

  13. News from Online: A Spectrum of Color

    Science.gov (United States)

    Sweeney Judd, Carolyn

    1999-06-01

    an experiment that is suitable for older students, Circles of Light--The Mathematics of Rainbows at http://www.geom.umn.edu/education/calc-init/rainbow/. Frederick J. Wicklin and Paul Edelman of the University of Minnesota note that this comprehensive lab is based on a module developed by Steven Janke. Go back to About Rainbows to link to a Java applet, allowing you to change the incident angle and color of light striking a water droplet. This great teaching device is from Fu-Kwun Hwang of the National Taiwan Normal University at http://science.kongju.ac.kr/phys/shin/experiment/ntnujava /Rainbow/rainbow.html. And while you are here in this site (choose English or Chinese), look at the more than 30 Java applets created by F.-K. Hwang at http://science.kongju.ac.kr/phys/shin/experiment/ntnujava/index.html. The interactive applet on Shadow/Image and Color is great fun, (http://science.kongju.ac.kr/phys/shin/experiment/ntnujava/shadow /shadow.html). From mixing colors, we can go to Thomas Chasteen's fine work at http://www.shsu.edu/~chm_tgc/sounds/sound.html for an animation (and movie also) of how to separate colors using a tuneable monochromator ( http://www.shsu.edu/~chemistry/monochromator/mono.gif). This colorful graphic, showing incoming parallel white light, is clipped from that monochromator animation. While you are here at this site at Sam Houston State University, look at the other great animations and movies, including a movie showing solution-phase chemiluminescence at http://www.shsu.edu/~chm_tgc/chemilumdir/movie.html. So now that we have explored the breaking down of light into its component colors, we need to also look at another process--polarizing light. Let's go to Science Media's comprehensive site ( http://www.scimedia.com/index.html#scimedia) to examine polarized light ( http://www.scimedia.com/chem-ed/spec/molec/polarim.htm). Of course, most sunglasses polarize light--bringing us back to the question of the rainbow again. Explore here for a while

  14. Šaukėnų šnektos veiksmažodžio asmenavimo sistema (vientisinės formos

    Directory of Open Access Journals (Sweden)

    Albertas Rosinas

    2011-12-01

    -stem verbs constitute a highly productive and stable class while in the subdialect there have remained only four i̯a (former i - stem verbs: tí·l̑ : ti·líeti, gál̑ : galíeti, mí·l̑ : mi·líeti  and gúl̑ : gulíeti. The verbs of the 2nd conjugation (or a-stem are also rather productive.The Šaukėnai subdialect has preserved some remnants of athematic conjugation. Some verbs are impersonal, e.g. per̃št, the others possess all personal forms derived from underlying form stems, e.g. mĩ·i̯ktu, etc.The categories in the Šaukėnai subdialect indicate a variety of symbolization.The categories of person and number are usually represented by grammatical morphemes, or endings (i.e. the morphological markers of the categories: /-u/, /-a·u/symbolize the categories of person and number, i.e.  the 1st person and the singular, /-i/, /-a· /, /-e· / -- the 2nd person and the singular /-am/, /-uom/, /-iem/, /-ma/--  the 1st person and the plural, /-at/, /-uot/, /-iet/, /-te/-- the 2nd person and the plural. The ending forms of the 3rd person represent the category of person, i.e. the 3rd person only.The article rejects the opinion, which dominates in Lithuanian linguistic literature, as if the verbal form endings could also represent the category of tense. It is complete misunderstanding, cf. sak-á·u (present and suk-á·u (past, mùš-ù (present and mùš-ù (future, etc. As evidenced by the data from the Šaukėnai subdialect, the tense can be expressed by syntactic category markers, phonological means, cf. mat-á·u and mač̑-ǽ·u, various formants (infixes, such as –n-, -st-, -s-, cf. añk and ãka, ki̲m̃b and kì̲ba, ti̲r̃pst  and ti̲r̃pa, dí̲́rbu and dí̲́rpsu, suffixes, cf. dí̲́rb-a·u and dí̲́rb-dav-a·u as well as vowel gradation, cf. ker̃t and ki̲r̃ta, etc. However, only the simple form endings of the indicative and subjunctive moods can express the mood.The forms of the subjunctive mood, alongside their specific

  15. Lithuanian Cluster of Sea Economics – Instrument of Sustainable Regional Development Lietuvos jūrų ūkio klasteris – darnios regiono plėtros instrumentas

    Directory of Open Access Journals (Sweden)

    Violeta Grublienė

    2011-02-01

    ;">Pasaulio ir Lietuvos ekonomikoje vyksta gilūs ir fundamentalūs pokyčiai, iš esmės keičiantys nusistovėjusias tarptautinės konkurencijos žaidimo taisykles. Klasterių reiškinys nagrinėjamas, klasteriai sąmoningai formuojami jau beveik du dešimtmečius. Todėl pagrindinis klasterių politikos objektas yra ne pavienės įmonės, bet visos regiono pramonės sistemos, palaikančios produktyvius veikėjų ryšius, sukūrimas. Pasaulinė patirtis rodo, kad klasterių požiūriu grindžiama politika atspindi besikeičiantį valstybės vaidmenį pramonės politikoje iš tiesioginės intervencijos į netiesioginę įtaką. Tokios šalys kaip Lietuva, įgyvendindamos klasterių politiką, susiduria su papildomomis problemomis. Klasterių politika reikalauja visiškai kitokios viešojo administravimo kompetencijos kokybės nei buvo įprasta pastaraisiais 50 metų. Klasterizacijos svarbą lemia pati ekonominės veiklos ir bendrųjų pramonės ir verslo raidos tendencijų logika. Lietuvoje šiuo metu egzistuojanti ūkio struktūra lemia tai, kad įmonėms neišvengiamai teks suderinti dvi kokybes: gebėjimą konkuruoti žemesne kaina ir novatoriškumą. Šiuo metu Lietuvos ūkis yra tokiame raidos etape, kuriame sėkmę visų pirma lemia efektyvumas ir valdymo kokybė. Straipsnio tikslas aptarti Lietuvos jūrų žuvininkystės sektoriaus būklę, įvertinti klasterio suformavimo galimybę darnios regiono plėtros kontekste.

  16. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2003-07-01

    , Glenford D. Howe ,The empowering impulse: The nationalist tradition of Barbados. Kingston: Canoe Press, 2001. xiii + 354 pp., Don D. Marshall (eds -Jean Stubbs, Alejandro de la Fuente, A Nation for All: Race, Inequality, and Politics in Twentieth-Century Cuba. Chapel Hill: University of North Carolina Press, 2001. xiv + 449 pp. -Sheryl L. Lutjens, Susan Kaufman Purcell ,Cuba: The contours of Change. Boulder CO: Lynne Rienner, 2000. ix + 155 pp., David J. Rothkopf (eds -Jean-Germain Gros, Robert Fatton Jr., Haiti's predatory republic: The unending transition to democracy. Boulder CO: Lynn Rienner, 2002. xvi + 237 pp. -Elizabeth McAlister, Beverly Bell, Walking on fire: Haitian Women's Stories of Survival and Resistance. Ithaca NY: Cornell University Press, 2001. xx + 253 pp. -Gérard Collomb, Peter Hulme, Remnants of conquest: The island Caribs and their visitors, 1877-1998. Oxford: Oxford University Press, 2000. 371 pp. -Chris Bongie, Jeannie Suk, Postcolonial paradoxes in French Caribbean Writing: Césaire, Glissant, Condé. New York: Oxford University Press, 2001. 216 pp. -Marie-Hélène Laforest, Caroline Rody, The Daughter's return: African-American and Caribbean Women's fictions of history. New York: Oxford University Press, 2001. x + 267 pp. -Marie-Hélène Laforest, Isabel Hoving, In praise of new travelers: Reading Caribbean migrant women's writing. Stanford CA: Stanford University Press, 2001. ix + 374 pp. -Catherine Benoît, Franck Degoul, Le commerce diabolique: Une exploration de l'imaginaire du pacte maléfique en Martinique. Petit-Bourg, Guadeloupe: Ibis Rouge, 2000. 207 pp. -Catherine Benoît, Margarite Fernández Olmos ,Healing cultures: Art and religion as curative practices in the Caribbean and its diaspora. New York: Palgrave, 2001. xxi + 236 pp., Lizabeth Paravisini-Gebert (eds -Jorge Pérez Rolón, Charley Gerard, Music from Cuba: Mongo Santamaría, Chocolate Armenteros and Cuban musicians in the United States. Westport CT: Praeger, 2001. xi + 155 pp

  17. 16th International Conference on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2016)

    International Nuclear Information System (INIS)

    2016-01-01

    , JAPAN Reza Ghodssi - University of Maryland Einar Halvorsen - Grenoble Alpes Université, FRANCE Hiroki Kuwano-Tohoku University, JAPAN Jeff Lang - Massachusetts Institute of Technology, USA Carol Livermore - Northeastern University, USA Ryutaro Maeda - National Institute of Advanced Industrial Science and Technology, JAPAN Kazusuke Maenaka - University of Hyogo, JAPAN Paul Mitcheson - Imperial College London, UK Yuji Suzuki - University of Tokyo, JAPAN Shuji Tanaka -Tohoku University, JAPAN Luis Velásquez-García - Massachusetts Institute of Technology, USA Peter Woias - University Freiburg-IMTEK, GERMANY Eric Yeatman - Imperial College London, UK Technical Program Committee Mahmoud Almasri, University of Missouri, USA David Arnold, University of Florida, USA Mustafa Beyaz, Antalya International University, TURKEY Danick Briand, EPFL, SWITZERLAND Stephen Burrow, Univesrity of Bristol, UK Francesco Cottone, University of Perugia, ITALY Alper Erturk, Georgia Institute of Technology, USA Luis Fonseca, IMB-CNM (CSIC)Micro-Nanosytems, SPAIN Takayuki Fujita, University of Hyogo, JAPAN Dimitri Galayko, UPMC-Sorbonne, FRANCE Tzeno Galchev, Analog Devices Inc., USA Gideon Gouws, Victoria University of Wellington, NEW ZEALAND Andrew Holmes, Imperial College London, UK Yoshihiro Kawahara, The University of Tokyo, JAPAN Sang-Woo Kim, Sungkyunkwan University, SOUTH KOREA Jeffrey Lang, Massachusetts Institute of Technology, USA Janet Ledesma-García, Universidad Autónoma de Querétaro, MEXICO Carol Livermore, Northeastern University, USA Yiannos Manoli, University of Freiburg, GERMANY Jianmin Miao, Nanyang Technological University, SINGAPORE Paul Mitcheson, Imperial College London, UK Koji Miyazaki, Kyushu Institute of Technology, JAPAN Jaeyeong Park, Kwangwoon University, KOREA Michael Renaud, Holst Centre-lmec NL, NETHERLANDS Paul Ronney, University of Southern California, USA Shad Roundy, University of Utah, USA Tomonori Seki, OMRON Corporation, JAPAN Yuji Suzuki, The

  18. INTRODUCTION Introduction to the conference proceeding of the Workshop on Electromagnetic Inverse ProblemsThe University of Manchester, UK, 15-18 June, 2009

    Science.gov (United States)

    Dorn, Oliver; Lionheart, Bill

    2010-11-01

    This proceeding combines selected contributions from participants of the Workshop on Electromagnetic Inverse Problems which was hosted by the University of Manchester in June 2009. The workshop was organized by the two guest editors of this conference proceeding and ran in parallel to the 10th International Conference on Electrical Impedance Tomography, which was guided by Bill Lionheart, Richard Bayford, and Eung Je Woo. Both events shared plenary talks and several selected sessions. One reason for combining these two events was the goal of bringing together scientists from various related disciplines who normally might not attend the same conferences, and to enhance discussions between these different groups. So, for example, one day of the workshop was dedicated to the broader area of geophysical inverse problems (including inverse problems in petroleum engineering), where participants from the EIT community and from the medical imaging community were also encouraged to participate, with great success. Other sessions concentrated on microwave medical imaging, on inverse scattering, or on eddy current imaging, with active feedback also from geophysically oriented scientists. Furthermore, several talks addressed such diverse topics as optical tomography, photoacoustic tomography, time reversal, or electrosensing fish. As a result of the workshop, speakers were invited to contribute extended papers to this conference proceeding. All submissions were thoroughly reviewed and, after a thoughtful revision by the authors, combined in this proceeding. The resulting set of six papers presenting the work of in total 22 authors from 5 different countries provides a very interesting overview of several of the themes which were represented at the workshop. These can be divided into two important categories, namely (i) modelling and (ii) data inversion. The first three papers of this selection, as outlined below, focus more on modelling aspects, being an essential component of

  19. How Often do Giant Black Holes Become Hyperactive?

    Science.gov (United States)

    2010-12-01

    for field galaxies -- as some results have hinted -- but then decreased more rapidly, at some point the cluster fraction would be about equal to the field fraction. This may explain what is being seen in the local Universe. The Milky Way contains a supermassive black hole known as Sagittarius A* (Sgr A*, for short). Even though astronomers have witnessed some activity from Sgr A* using Chandra and other telescopes over the years, it has been at a very low level. If the Milky Way follows the trends seen in the ChaMP survey, Sgr A* should be about a billion times brighter in X-rays for roughly 1% of the remaining lifetime of the Sun. Such activity is likely to have been much more common in the distant past. If Sgr A* did become an AGN it wouldn't be a threat to life here on Earth, but it would give a spectacular show at X-ray and radio wavelengths. However, any planets that are much closer to the center of the Galaxy, or directly in the line of fire, would receive large and potentially damaging amounts of radiation. These results were published in the November 10th issue of the Astrophysical Journal. Other co-authors on the paper were Scott Anderson of the University of Washington, Anca Constantin from James Madison University, Tom Aldcroft and Dong-Woo Kim from Harvard-Smithsonian Center for Astrophysics and Wayne Barkhouse from the University of North Dakota. NASA's Marshall Space Flight Center in Huntsville, Ala., manages the Chandra program for NASA's Science Mission Directorate in Washington. The Smithsonian Astrophysical Observatory controls Chandra's science and flight operations from Cambridge, Mass. More information, including images and other multimedia, can be found at: http://chandra.harvard.edu and http://chandra.nasa.gov

  20. Granulated wood ash to forest soils. Effects on microorganisms, phosphorus availability, and spatial relationships in the humus layer

    International Nuclear Information System (INIS)

    Clarholm, Marianne

    1999-01-01

    according to the principal of cautiousness. Returning the increasing amounts of woo d ash coming from increased bioenergy use to the forest is also a better long term alternative than storage in a deposit with unknown future problems with leakage e.g. with heavy metals