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Sample records for hwan kim jong

  1. Dramaturgi Citra Pemimpin Korea Utara Kim Jong Un dalam Film The Interview Produksi Columbia Pictures

    OpenAIRE

    2016-01-01

    This study titled “Dramaturgy of the image of North Korean leader Kim Jong Un in the film The Interview”. The duration of The Interview film is 112 minutes told a story about the murder plan North Korean leader Kim Jong Un by intelligence services, the United States 'CIA' through two media workers that Dave Skylark and Aaron Rapoport, which is a host and producer of the program infotainment show in United States named Skylark Tonight. This study uses analysis of Erving Goffman Dramaturgy pers...

  2. Kim Jong IL and North Korea: The Leader and the System

    Science.gov (United States)

    2006-03-01

    bo rn d = di ed (f) = fe m al e Fi gu re 4 . T he K im F am ily . n o TE : C om pi le d by a ut ho r. 17 • Song Hye Rim: mother of Kim Jong...Madeleine Albright with Bill Woodward, Madam Secretary, New York: Miramax Books, 2003, p. 465. 20. Cited in Oh and Hassig, North Korea, p. 91. 21. Some...12. 28. Albright, with Woodward, Madam Secretary, pp. 462, 467. 29. For a more detailed analysis of North Korean intentions, see Andrew Scobell

  3. North Korean Leadership Dynamics and Decision-making under Kim Jong-un: A First Year Assessment

    Science.gov (United States)

    2013-09-01

    nuclear deterrent” up for discussion unless it is in the context of Korean Peninsula-wide denuclearization —code for securing a peace treaty with the...achieve denuclearization on the Korean Peninsula. This latter point of describ- ing its nuclear capability as necessary to achieve denuclearization is an...ar- gument that Pyongyang never made under Kim Jong-il. Instead, North Korea claimed it would need a nuclear deterrent until denuclearization had

  4. De jonge consument

    NARCIS (Netherlands)

    Buijzen, M.A.; Rozendaal, E.

    2012-01-01

    Kinderen vormen een steeds aantrekkelijkere doelgroep voor marketeers, adverteerders en voorlichters. Maar behalve een aantrekkelijke doelgroep is het ook een bijzondere: kinderen zijn immers nog in ontwikkeling en hebben daardoor specifieke kenmerken en gevoeligheden. Bij het benaderen van de jonge

  5. Lõuna-Korea teatel võib Kim peagi surra / Evelyn Kaldoja

    Index Scriptorium Estoniae

    Kaldoja, Evelyn, 1980-

    2009-01-01

    Viidates Lõuna-Korea ja Hiina luureandmetele, väidab Lõuna-Korea meedia, et Põhja-Korea liidril Kim Jong-ilil on kõhunäärmevähk ja talle pole antud elada rohkem kui 5 aastat. Põhja-Korea valitsejadünastia

  6. Lõuna-Korea teatel võib Kim peagi surra / Evelyn Kaldoja

    Index Scriptorium Estoniae

    Kaldoja, Evelyn, 1980-

    2009-01-01

    Viidates Lõuna-Korea ja Hiina luureandmetele, väidab Lõuna-Korea meedia, et Põhja-Korea liidril Kim Jong-ilil on kõhunäärmevähk ja talle pole antud elada rohkem kui 5 aastat. Põhja-Korea valitsejadünastia

  7. Voerbeperking op jonge leeftijd bij slachtkuikens

    NARCIS (Netherlands)

    Meijerhof, R.

    1990-01-01

    Uit onderzoek in het buitenland is gebleken dat voerbeperking op jonge leeftijd bij slachtkuikens onder andere leidt tot een verminderde vetaanzet. Eerste resultaten van het proefbedrijf in Maarheeze wijzen op een duidelijke achterstand in groei.

  8. Vlees van jonge stieren (baby-beef)

    NARCIS (Netherlands)

    Harmsen, H.E.; Seignette, A.

    1985-01-01

    In 1983 werd door het PR, Wolff-Vlees B.V. en Denkavit B.V. een aantal proeven uitgevoerd om meer inzicht te krijgen in de technische en economische aspecten van de vleesproductie met jonge stieren. De proeven werden uitgevoerd met zwartbonte stierkalveren met een mestperiode van 40 tot 58 weken.

  9. Vlees van jonge stieren (baby-beef)

    NARCIS (Netherlands)

    Harmsen, H.E.; Seignette, A.

    1985-01-01

    In 1983 werd door het PR, Wolff-Vlees B.V. en Denkavit B.V. een aantal proeven uitgevoerd om meer inzicht te krijgen in de technische en economische aspecten van de vleesproductie met jonge stieren. De proeven werden uitgevoerd met zwartbonte stierkalveren met een mestperiode van 40 tot 58 weken.

  10. The New North Korean Problem: History and Responsibilities in the Age of Kim Jong Un

    Science.gov (United States)

    2012-03-29

    goes back to the Korean War. The Soviets assisted the North with creating a research facility in 1952.19 While Soviet, 8 Chinese, and US...fire, North Korea immediately resumed the nuclear testing and operations at its facilities that it had previously suspended.31 Since the world...be the successor, however, his loyalty to his father and the regime became suspect when he attempted to enter Tokyo to go to Tokyo Disney on a fake

  11. North Korea’s Provocation and Escalation Calculus: Dealing with the Kim Jong-un Regime

    Science.gov (United States)

    2015-08-01

    level” provocations while minimizing risks of potential rapid conflict escalation remains a central dilemma as was demonstrated in the reaction to North...Korean summit because of Seoul’s attempts to “depolitize” the event by keeping it purely at “the artistic, athletic, and cultural ” level. This was

  12. The Ten Thousand Kims

    CERN Document Server

    Baek, Seung Ki; Kim, Beom Jun; 10.1088/1367-2630/13/7/073036

    2011-01-01

    In the Korean culture the family members are recorded in special family books. This makes it possible to follow the distribution of Korean family names far back in history. It is here shown that these name distributions are well described by a simple null model, the random group formation (RGF) model. This model makes it possible to predict how the name distributions change and these predictions are shown to be borne out. In particular, the RGF model predicts that, for married women entering a collection of family books in a certain year, the occurrence of the most common family name "Kim" should be directly proportional the total number of married women with the same proportionality constant for all the years. This prediction is also borne out to high degree. We speculate that it reflects some inherent social stability in the Korean culture. In addition, we obtain an estimate of the total population of the Korean culture down to year 500 AD, based on the RGF model and find about ten thousand Kims.

  13. The ten thousand Kims

    Science.gov (United States)

    Baek, Seung Ki; Minnhagen, Petter; Kim, Beom Jun

    2011-07-01

    In Korean culture, the names of family members are recorded in special family books. This makes it possible to follow the distribution of Korean family names far back in history. It is shown here that these name distributions are well described by a simple null model, the random group formation (RGF) model. This model makes it possible to predict how the name distributions change and these predictions are shown to be borne out. In particular, the RGF model predicts that for married women entering a collection of family books in a certain year, the occurrence of the most common family name 'Kim' should be directly proportional to the total number of married women with the same proportionality constant for all the years. This prediction is also borne out to a high degree. We speculate that it reflects some inherent social stability in the Korean culture. In addition, we obtain an estimate of the total population of the Korean culture down to the year 500 AD, based on the RGF model, and find about ten thousand Kims.

  14. Loe de Jong 1914-2005: historicus met een missie

    NARCIS (Netherlands)

    Smits, Boudewijn

    2014-01-01

    A self-willed man, unswayed by criticism. A man with a definite mission. This is the picture painted by the biography of historian Loe de Jong, for which Boudewijn Smits will be awarded a PhD by the University of Groningen on 24 April, to coincide with what would have been De Jong’s one hundredth

  15. North Korean Leadership Dynamics and Decision-making under Kim Jong-un: A Second Year Assessment

    Science.gov (United States)

    2014-03-01

    Suryong is an impeccable brain of the living body, the masses can be endowed with their life in exchange for their loyalty to him, and the Party is the...rarely used in North Korean mass media. It later became personified as Nodong Sinmun increasingly cited the “Party Center” (tang chungang) as the brains ... teens , were

  16. Religious Franks. Religion and power in the Frankish Kingdoms. Studies in honour of Mayke de Jong

    NARCIS (Netherlands)

    Meens, R.M.J.; Espelo, D.B. van; Hoven van Genderen, B.; Raaijmakers, J.; Renswoude, I. van; Rhijn, C. van

    2016-01-01

    This volume in honour of Mayke De Jong offers twenty-five essays focused upon the importance of religion to Frankish politics, a discourse to which De Jong herself has contributed greatly in her academic career. The prominent and internationally renowned contributors offer fresh perspectives on vari

  17. Veel haring, maar vrijwel geen jonge kabeljauw: International Bottom Trawl Survey 2003

    NARCIS (Netherlands)

    Heessen, H.J.L.

    2003-01-01

    Onderzoeksvaartuigen hebben de jaarlijkse International Bottom Trawl Survey (IBTS) uitgevoerd om een indruk te krijgen van de jongste jaarklassen van jonge haring, sprot en rondvis. Overzicht van de bestanden van kabeljauw, schelvis, wijting en haring 1978-2002

  18. Prof. Il-Hoi Kim: a tribute.

    Science.gov (United States)

    Huys, Rony

    2016-10-11

    Prof. Il-Hoi Kim was born during the Korean War on 28 February 1952 in Buan, North Jeolla Province (South Korea), near the coast of the Yellow Sea whose tidal flats would become one of his favourite sampling grounds during his scientific career. From an early age he developed an intense interest in natural history in general and marine biology in particular. He obtained his B.Sc. in 1974 at the Department of Biology Education, Gongju National College of Education. Between 1974 and 1976 he was conscripted into the South Korean military during which he progressed to the rank of lieutenant of artillery in the Reserve Officers' Training Corps (ROTC). After his graduation in 1980 at the Department of Zoology, Seoul National University, Il-Hoi Kim moved to the Department of Biology, Gangneung-Wonju National University on the East Sea coast where he was first appointed lecturer (1981) before taking up the position of assistant professor (1983), associate professor (1987) and full professor (1993). In 1985 he had previously completed his Ph.D. dissertation on Korean barnacles at Seoul National University under the supervision of the late Prof. Hoon Soo Kim, a pioneer in marine invertebrate taxonomy and renowned as the father of carcinology in Korea.

  19. Effects of Gyejibongnyeong-hwan on dysmenorrhea caused by blood stagnation: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Park Jeong-Su

    2012-01-01

    Full Text Available Abstract Background Gyejibongnyeong-hwan (GJBNH is one of the most popular Korean medicine formulas for menstrual pain of dysmenorrhea. The concept of blood stagnation in Korean medicine is considered the main factor of causing abdominal pain, or cramps, during menstrual periods. To treat the symptoms, GJBNH is used to fluidify the stagnated blood and induce the blood flow to be smooth, reducing pain as the result. The purpose of this trial is to identify the efficacy of GJBNH in dysmenorrhea caused by blood stagnation. Methods This study is a multi-centre, randomised, double-blind, controlled trial with two parallel arms: the group taking GJBNH and the group taking placebo. 100 patients (women from age 18 to 35 will be enrolled to the trial. Through randomization 50 patients will be in experiment arm, and the other 50 patients will be in control arm. At the second visit (baseline, all participants who were already screened that they fulfil both the inclusion and the exclusion criteria will be randomised into two groups. Each group will take the intervention three times per day during two menstrual cycles. After the treatment for two cycles, each patient will be followed up during their 3rd, 4th and 5th menstrual cycles. From the screening (Visit 1 through the second follow-up (Visit 6 the entire process will take 25 weeks. Discussion This trial will provide evidence for the effectiveness of GJBNH in treating periodical pain due to dysmenorrhea that is caused by blood stagnation. The primary outcome between the two groups will be measured by changes in the Visual Analogue Score (VAS of pain. The secondary outcome will be measured by the Blood Stagnation Scale, the Short-form McGill questionnaire and the COX menstrual symptom scale. Analysis of covariance (ANCOVA and repeated measured ANOVA will be used to analyze the data analysis. Trial registration Current Controlled Trials: ISRCTN30426947

  20. Factor structure of the De Jong Gierveld loneliness scale in Spanish elderly adults

    Directory of Open Access Journals (Sweden)

    José Buz

    2014-05-01

    Full Text Available Loneliness is an important component in the measurement of subjective well-being of elderly adults. The most influential instrument in Europe is the 11-item de Jong Gierveld loneliness scale (DJGLS; de Jong Gierveld and Kamphuis, 1985. The aim of this study was to examine, throughout factorial techniques, the internal structure the Spanish version of the DJGLS. Data were gathered from 328 community-dwelling elderly adults (M = 75.53, Range: 60-99 years. The factor analysis techniques revealed that the scale was essentially unidimensional (RMR = .088, AGFI = .970, NFI = .966. Reliability was .91. Neither substantive nor statistical reasons were found to consider the existence of a second factor. Our findings also revealed some psychometric problems in the measurement of the social and emotional aspects of loneliness. Emphasis is placed on the need to improve the scale and bear in mind the differences between collectivist and individualist cultures in the use of scales measuring well-being.

  1. Practice makes perfect: the neural substrates of tactile discrimination by Mah-Jong experts include the primary visual cortex

    Directory of Open Access Journals (Sweden)

    Honda Manabu

    2006-12-01

    Full Text Available Abstract Background It has yet to be determined whether visual-tactile cross-modal plasticity due to visual deprivation, particularly in the primary visual cortex (V1, is solely due to visual deprivation or if it is a result of long-term tactile training. Here we conducted an fMRI study with normally-sighted participants who had undergone long-term training on the tactile shape discrimination of the two dimensional (2D shapes on Mah-Jong tiles (Mah-Jong experts. Eight Mah-Jong experts and twelve healthy volunteers who were naïve to Mah-Jong performed a tactile shape matching task using Mah-Jong tiles with no visual input. Furthermore, seven out of eight experts performed a tactile shape matching task with unfamiliar 2D Braille characters. Results When participants performed tactile discrimination of Mah-Jong tiles, the left lateral occipital cortex (LO and V1 were activated in the well-trained subjects. In the naïve subjects, the LO was activated but V1 was not activated. Both the LO and V1 of the well-trained subjects were activated during Braille tactile discrimination tasks. Conclusion The activation of V1 in subjects trained in tactile discrimination may represent altered cross-modal responses as a result of long-term training.

  2. Kim Dotcomi kättemaks / Andy Greenberg

    Index Scriptorium Estoniae

    Greenberg, Andy

    2013-01-01

    Skandaalne Internetimagnaat Kim Schmitz, rohkem tuntud kui Kim Dotcom, on veendunud, et tema loodud failivahetusprogrammi Megauploadi mahavõtmisega ja autoriõiguste rikkumise süüdistusega tehti talle liiga ning ta on asunud raevukalt vastulöögile USA valitsuse vastu

  3. Kim Dotcomi kättemaks / Andy Greenberg

    Index Scriptorium Estoniae

    Greenberg, Andy

    2013-01-01

    Skandaalne Internetimagnaat Kim Schmitz, rohkem tuntud kui Kim Dotcom, on veendunud, et tema loodud failivahetusprogrammi Megauploadi mahavõtmisega ja autoriõiguste rikkumise süüdistusega tehti talle liiga ning ta on asunud raevukalt vastulöögile USA valitsuse vastu

  4. Tumor initiation inhibition through inhibition COX-1 activity of a traditional Korean herbal prescription, Geiji-Bokryung-Hwan, in human hepatocarcinoma cells.

    Science.gov (United States)

    Park, Won-Hwan; Lee, Soo-Kyung; Oh, Hoon-Kyu; Bae, Jong-Yub; Kim, Cheorl-Ho

    2005-01-01

    Some Korean and oriental herbal prescriptions used for a syndrome expressed as chest paralysis and heartache are thought to be effective for angina pectoris. We investigated the effects of an oriental medicinal prescription, Geiji-Bokryung-Hwan (GBH) consisting of herbs of Cinnamomi Ramulus, Poria Cocos Hoelen (Pachymae Fungus), Moutan Cortex Radicis, Paeoniae Radix, and Persicae Semen, on growth-inhibitory activity and cancer chemopreventive activity in assays representing three major stages of carcinogenesis. The GBH was found to act as an potent inhibitor of cyclooxygenase (COX)-1 only but not as COX-2 inhibitor. Furthermore, the extract mediated anti-inflammatory effects and inhibited COX-associated hydroperoxidase functions (anti-promotion activity). Inhibitory effect of the GBH on the growth of cancer cell lines such as HepG2 cell and Hep3B cell was shown. These data suggest that GBH extracts merit investigation as a potential cancer chemopreventive agent in humans, especially in hepatological cancers.

  5. Insoo Kim Berg and Solution-Focused Therapy.

    Science.gov (United States)

    West, John D.; Bubenzer, Donald L.; Smith, Jeffrey M.; Hamm, Terri L.

    1997-01-01

    Interview with Insoo Kim Berg, a leading theoretician in solution-based therapy. She is joined by Steve de Shazer, a colleague. They discuss the evolution of her work and its application to various populations. (MKA)

  6. Groen mbo niet nodig voor groene carrière : onderzoekers in kritisch essay (interview met W. de Jong)

    NARCIS (Netherlands)

    Boetzkes, P.; Jong, de L.W.

    2011-01-01

    Het groen mbo heeft in zijn huidige vorm onvoldoende meerwaarde voor de arbeidsmarkt in de tuinbouw, agro & food. Vooral waar het uitvoerend werk betreft. Daarom kan de overheid het extra geld dat ze erin steekt beter anders investeren. Dat stelt onderzoeker Wim de Jong.

  7. Coenite seiklused ja Kim Ki-duki huumor / Merit Kask

    Index Scriptorium Estoniae

    Kask, Merit

    2007-01-01

    60-nda Cannes'i filmifestivali filme : Ethan ja Joel Coen'i "Pole maad vanadele meestele" ("No Country for Old Men" ; Ameerika Ühendriigid), Kim Ki-duki "Hingetõmme" ("Soom"/"Breath" ; Lõuna-Korea) ja Raphael Nadjari "Tehilim" (Prantsusmaa - Iisrael - Ameerika Ühendriigid)

  8. Prikljutshenija Koenov i jumor Kim Ki-duka / Merit Kask

    Index Scriptorium Estoniae

    Kask, Merit

    2007-01-01

    60-nda Cannes'i filmifestivali filme : Ethan ja Joel Coen'i "Pole maad vanadele meestele" ("No Country for Old Men" ; Ameerika Ühendriigid), Kim Ki-duki "Hingetõmme" ("Soom"/"Breath" ; Lõuna-Korea) ja Raphael Nadjari "Tehilim" (Prantsusmaa - Iisrael - Ameerika Ühendriigid)

  9. Coenite seiklused ja Kim Ki-duki huumor / Merit Kask

    Index Scriptorium Estoniae

    Kask, Merit

    2007-01-01

    60-nda Cannes'i filmifestivali filme : Ethan ja Joel Coen'i "Pole maad vanadele meestele" ("No Country for Old Men" ; Ameerika Ühendriigid), Kim Ki-duki "Hingetõmme" ("Soom"/"Breath" ; Lõuna-Korea) ja Raphael Nadjari "Tehilim" (Prantsusmaa - Iisrael - Ameerika Ühendriigid)

  10. Prikljutshenija Koenov i jumor Kim Ki-duka / Merit Kask

    Index Scriptorium Estoniae

    Kask, Merit

    2007-01-01

    60-nda Cannes'i filmifestivali filme : Ethan ja Joel Coen'i "Pole maad vanadele meestele" ("No Country for Old Men" ; Ameerika Ühendriigid), Kim Ki-duki "Hingetõmme" ("Soom"/"Breath" ; Lõuna-Korea) ja Raphael Nadjari "Tehilim" (Prantsusmaa - Iisrael - Ameerika Ühendriigid)

  11. The antiplatelet activity of Geiji-Bokryung-Hwan, Korean traditional formulation, is mediated through inhibition of phospholipase C and inhibition of TxB(2) synthetase activity.

    Science.gov (United States)

    Park, Won-Hwan; Kim, Kyoung-Sook; Kim, Kyung-Ho; Kim, Dong-Soo; Kim, Cheorl-Ho

    2003-07-01

    Geiji-Bokryung-Hwan (GBH), consisting of herbes of Cinnamomi ramulus (Geiji), Poria cocos (Bokryun), Mountan cortex radicis (Mokdanpi), Paeoniae radix (Jakyak), and Persicae semen (Doin), on antiplatelet activity in human platelet suspensions was studied. The mechanism involved in the antiplatelet activity of GBH in human platelet suspensions was investigated. GBH did not significantly affect the thromboxane synthetase activity of aspirin-treated platelet microsomes and GBH (15 and 30 microg/ml) significantly inhibited [3H]arachidonic acid released in collagen-activated platelets but not in unactivated-platelets. Nitric oxide (NO) production in human platelets was measured by a chemiluminesence detection method in this study. GBH did not significantly affect nitrate production in collagen (10 microg/ml)-induced human platelet aggregation. Various concentrations of GBH (0, 5, 10, 15, and 30 microg/ml) dose-dependently inhibited [3H]inositol monophosphate formation stimulated by collagen (10 microg/ml) in [3H]myoinositol-loaded platelets at different incubation times (1, 2, 3, and 5 min). These results indicated that the antiplatelet activity of GBH may possibly be due to the inhibition of phospholipase C (PLC) activity, leading to reduce phosphoinositide breakdown, followed by the inhibition of thromboxane A(2) formation, and then inhibition of [Ca(2+)](i) mobilization of platelet aggregation stimulated by agonists. In conclusion, GBH suppressed PLC in a dose-dependent manner, and may have pharmaceutical applications. These data suggest that GBH extracts merit investigation as a potential anti-atherosclerogenic agent in humans.

  12. High-throughput screening of inhibitory effects of Bo-yang-hwan-o-tang on human cytochrome P450 isoforms in vitro using UPLC/MS/MS.

    Science.gov (United States)

    Lee, Miran; Park, Jeonghyeon; Lim, Mi-sun; Seong, Sook Jin; Lee, Joomi; Seo, Jeong Ju; Park, Yong-Ki; Lee, Hae Won; Yoon, Young-Ran

    2012-01-01

    Bo-yang-hwan-o-tang (BHT) is an oriental herbal medicine for treating brain disorders such as cerebral ischemia. The objective of this study was to develop an economically feasible and time-saving high-throughput screening method to monitor the potential inhibitory effects of BHT on human cytochrome P450 (CYP) enzymes in vitro. Two cocktail sets were used for incubation of human liver microsomes: Cocktail A: 6 probe substrates for CYP1A2, CYP2A6, CYP2C8, CYP2C19, CYP2D6, CYP3A4; Cocktail B: 3 for CYP2B6, CYP2C9, CYP2E1. The concentrations of the substrate metabolites were simultaneously analyzed using UPLC/MS/MS. The BHT extract had almost negligible inhibitory effects on the nine human CYP isoforms tested, with the half-maximal inhibitory concentration value ranged from 3624.99 to 45412.44 μg/ml. The results suggest that BHT extract has no inhibitory effects on CYP isoforms within the clinically recommended dosage range. We conclude that BHT might be free of drug-herb interactions when co-administered with other medicines. However, more in vivo human studies are needed to confirm these results. The high-throughput screening method can be a useful tool for drug discovery and for understanding drug interactions.

  13. Loe de Jong, of de professionele strategieën van een publieke intellectueel in Koude Oorlogstijd

    Directory of Open Access Journals (Sweden)

    Pieter Lagrou

    2015-09-01

    Full Text Available Loe de Jong or the Professional Strategies of a Public Intellectual in the Cold War PeriodBoudewijn Smits’ biography of Loe de Jong tells four stories – the life of the author of the 16,600 pages long standard history of the Netherlands during the Second World War, that of the son of an Amsterdam milkman who lost his entire family in the Holocaust but then went on to become a celebrated national symbol, one of the most prominent media figures in the post-war Netherlands, in the printed press, radio and television, and finally that of the director and personification of a most peculiar Dutch institution, the State Institute for War Documentation. Smits offers an insightful analysis of how these four lives intertwined in the person of Loe de Jong and thus portrays in an original way the making of a Cold War public intellectual.Boudewijn Smits’ biografie van Loe de Jong vertelt vier levens: dat van de gevierde historicus, auteur van de 16.600 bladzijden tellende Het Koninkrijk der Nederlanden in de Tweede Wereldoorlog; dat van de zoon van een Joodse melkboer in Amsterdam die zijn hele familie verloor in de Jodenvervolging, maar na 1945 een gevierd nationaal symbool werd; dat van een van de prominentste mediafiguren in naoorlogs Nederland, in de geschreven pers, radio en televisie en dat van de directeur en verpersoonlijking van een wel erg bijzondere instelling, het Rijksinstituut voor Oorlogsdocumentatie. De manier waarop die vier levens zich in de persoon van De Jong verstrengelen wordt op boeiende manier ontleed en portretteert de unieke figuur van een publieke intellectueel in Koude Oorlogstijd.

  14. Semantic Annotation Framework For Intelligent Information Retrieval Using KIM Architecture

    Directory of Open Access Journals (Sweden)

    Sanjay Kumar Malik

    2010-11-01

    Full Text Available Due to the explosion of information/knowledge on the web and wide use of search engines for desiredinformation,the role of knowledge management(KM is becoming more significant in an organization.Knowledge Management in an Organization is used to create ,capture, store, share, retrieve and manageinformation efficiently. The semantic web, an intelligent and meaningful web, tend to provide a promisingplatform for knowledge management systems and vice versa, since they have the potential to give eachother the real substance for machine-understandable web resources which in turn will lead to anintelligent, meaningful and efficient information retrieval on web. Today,the challenge for web communityis to integrate the distributed heterogeneous resources on web with an objective of an intelligent webenvironment focusing on data semantics and user requirements. Semantic Annotation(SA is being widelyused which is about assigning to the entities in the text and links to their semantic descriptions. Varioustools like KIM, Amaya etc may be used for semantic Annotation.In this paper, we introduce semantic annotation as one of the key technology in an intelligent webenvironment , then revisit and review, discuss and explore about Knowledge Management and SemanticAnnotation. A Knowledge Management Framework and a Framework for Semantic Annotation andSemantic Search with Knowledge Base(GATE and Ontology have been presented. Then KIM Annotationplatform architecture including KIM Ontology(KIMO, KIM Knowledge Base and KIM front ends havebeen highlighted. Finally, intelligent pattern search and concerned GATE framework with a KIMAnnotation Example have been illiustrated towards an intelligent information retrieval

  15. Water Quality Characteristics of Jonge Telaga (Doline Pond as Water Resources for the People of Semanu District Gunungkidul Regency

    Directory of Open Access Journals (Sweden)

    M. Widyastuti

    2017-01-01

    Full Text Available Abstract Doline ponds (telaga have an important role as one of water resources in karst areas, especially during dry seasons in Gunungkidul. Recently, the doline ponds are facing various environmental problems, i.e. steadily decreasing water storage, water loss, and degrading water quality. The research aims to determine the characteristics of Jonge Telaga which include the continuity of flow, utilization, pollution sources, physical water quality (temperature, EC,TDS, TSS, and turbidity, chemical water quality (pH , NO2, NO3, NH4, PO4, BOD , COD, and detergent, and biological water quality (total coliform. In order to determine the characteristics of Jonge Telaga, the research was conducted using a survey method, i.e., observing the continuity of flow and measuring physical, chemical, and biological water quality. Initially, the water was sampled purposively based on the area and the depth of this doline pond. The qualitative description of the results shows that Jonge Telaga is a closed perennial doline pond, whose main pollution source comes from domestic activities, such as bathing and washing. According to the Governor Regulation of the Special Region of Yogyakarta Number 20 Year 2008 on Water Quality Standards, Jonge Telaga meets all of the water quality criteria, except the temperature and detergent, for a Class II water. Abstrak Telaga mempunyai peran penting sebagai salah satu sumberdaya air di daerah karst, khususnya pada musim kemarau di Kabupaten Gunungkidul. Pada saat ini telaga menghadapi berbagai permasalahan lingkungan yaitu simpanan air yang terus berkurang, air yang cepat hilang, dan penurunan kualitas air. Tujuan penelitian adalah untuk mengetahui karakteristik telaga yang meliputi kontiyuitas aliran, pemanfaatan, sumber pencemar, kualitas fisik air telaga (TDS, TSS, suhu, kekeruhan, DHL, kimia air (pH, NH4, PO4, NO2, NO3, BOD, COD, deterjen dan biologi air (coliform total.  Penelitian ini dilaksanakan berdasarkan metode

  16. Status of the KIMS-NaI experiment

    CERN Document Server

    Kim, Kyungwon

    2015-01-01

    KIMS-NaI is a direct detection experiment searching for Weakly Interacting Massive Particles (WIMP) via their scattering off of nuclei in a NaI(Tl) crystal. The KIMS-NaI collaboration has carried out tests of six crystals in the Yangyang underground laboratory in order to develope low-background NaI(Tl) crystals. Studies of internal backgrounds crystals have been performed with the goal of reducing backgrounds levels to 1 dru at 2 keV. Pulse shape discrimination (PSD) capabilities were also investigated for distinguishing between WIMP nuclear recoil signals and electron recoil backgrounds. The PSD analysis was applied to underground data with one low background NaI(Tl) detector and the evaluation of WIMP mass limit is ongoing.

  17. Verification of tropical cyclone using the KIAPS Integration Model (KIM)

    Science.gov (United States)

    Lim, S.; Seol, K. H.

    2015-12-01

    The Korea Institute of Atmospheric Prediction Systems (KIAPS) is a government funded non-profit research and development institute located in Seoul, South Korea. KIAPS is developing the Global Model, a backbone for the next-generation operational global numerical weather prediction (NWP) system with three-phase plans; Establishment and R&D Planning (2011-2013), Test Model Development (2014-2016), and Operational Model Development (2017-2019). As a second-phase, we have beta version of KIAPS Integration Model (KIM) that can produce reasonable global forecasting. Using the KIM model, we are evaluating the tropical cyclone forecast in the global model. To objectively provide a best estimate of the storm's central position, we use the Geophysical Fluid Dynamics Laboratory (GFDL) vortex tracker, widely used in tracker algorithms. It gives the track and intensity of the storm throughout the duration of the forecast based on its algorithm. As a verification tool, we use the Model Evaluation Tool - Tropical Cyclone (MET-TC), which produces statistical evaluation. We expect these results give the statue of ability for the tropical cyclone forecast with KIM model.

  18. Perspektif Kim Knott tentang Insider-Outsider dalam Studi Agama

    Directory of Open Access Journals (Sweden)

    Sujiat Zubaidi Saleh

    2016-03-01

    Full Text Available Contemporary discourse of religious studies indicates many fields of study in understanding religion. Religious spectrum not only relates with credo, faith, worldview, theology and etcetera but expanding in various aspect (cultural and historical side. The cultural and historical aspects in a certain point give some problems in academic field. Kim Knott based on those matters tries to give a new shot in analyzing religion based on the issued aspects. Looking at how complicated is it Kim Knott maps it into two religious approaches. First is the hardship situation to make such a clear gap between religious and not-religious territory and second is the complicated problem in relation with religion as tradition and religion as faith. This article elucidates a viewpoint of Kim Knott as a “new outline” on religious studies. Knott attempts to eliminate the subjective intentions by using two basic perspectives of methodology: insider and outsider. He has classified the concept of inter-connection between social and religious role into four elements: pure participant, researcher as participant, participant as researcher and pure researcher. However, this concept remains an important problem concerning to standard of objectivity. Knott’s approach tries to place researcher on the margin of appreciation as a border line between insider-outsider.

  19. Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B.

    Science.gov (United States)

    Park, Won-Hwan; Joo, Shin-Tak; Park, Kwan-Kyu; Chang, Young-Chae; Kim, Cheorl-Ho

    2004-02-01

    We investigated the effects of a Korean traditional prescription, Geiji-Bokryung-Hwan (GBH) consisting of five herbs of Cinnamomi Ramulus (Korean name Geiji), Poria cocos (Bokryung), Moutan Cortex Radicis (Modanpi). Paeoniae Radix (Jakyak) and Persicae Semen (Doin) on tumor growth-inhibitory activity and cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Effects of the GBH extracts on carrageenan-induced edema inflammation using female (C57BL/6XC3H) F1 (B6C3F1) mice and tumorigenesis were examined. Finally, cyclooxygenase metabolites were determined after extracts treatment. These data suggest that GBH extracts merits investigation as a potential cancer chemopreventive agent in humans.

  20. Anmeldelse af Kim Wind Andersen: Overblik over selskabers underskudsfremførsel

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2011-01-01

    Artiklen anmelder Kim Wind Andersen: Overblik over selskabers underskudsfremførsel (Thomson Reuters Professional, 2010)......Artiklen anmelder Kim Wind Andersen: Overblik over selskabers underskudsfremførsel (Thomson Reuters Professional, 2010)...

  1. Chang Sei Kim's Activities on Public Health in Colonial Korea

    Directory of Open Access Journals (Sweden)

    Park Yunjae

    2006-12-01

    Full Text Available After graduating from Severance Medical College in 1916, Chang Sei Kim went to Shanghai to work as a missionary in a adventist hospital. The establishment of the Korean Provisional Government led him to participate in the independence movement. Educating nurses to assist the forthcoming war for independence, he seemed to realize the fact that the health of Koreans would be a key factor for achieving independence. He left for the U.S. to conduct comprehensive research on medicine. Chang Sei Kim was the first Korean to receive a Ph. D. degree of Public Health, graduating from the Johns Hopkins School of Hygiene and Public Health in 1925. He then gained an opportunity to work for Korea as a professor at Severance Medical College. His objective was the 'Reconstruction of the Korean People In Terms of Physical Constitution.' He pointed out that Koreans' weak state of health was a major reason for Korea's colonization. To gain independence, he emphasized that the Korean people should receive education on public health in order to improve the primitive conditions of sanitation. There is little doubt that Chang Sei Kim's ideas developed Heungsadan's views on medicine in terms of its stress on cultivation of ability, especially considering the fact that he was a member of the organization. As a member of the colonized who could not participate in the developing official policy, Chang Sei Kim was not able to implement his ideas fully, because an individual or a private organization could not carry out policy on public health as large a scale as the government did. Never giving up his hopes for Korean independence, he rejected requests to assume official posts in the Government-General. That was why he was particularly interested in the Self-Governing Movement in 1920s Korea. If the movement had attained its goal, he might have worked for the enhancement of sanitary environment as a director of Sanitary Department. His application for funding to establish

  2. Tubular kidney injury molecule-1 (KIM-1) in human renal disease

    NARCIS (Netherlands)

    van Timmeren, M. M.; van den Heuvel, M. C.; Bailly, V.; Bakker, S. J. L.; van Goor, H.; Stegeman, C. A.

    2007-01-01

    KIM-1, a transmembrane tubular protein with unknown function, is undetectable in normal kidneys, but is markedly induced in experimental renal injury. The KIM-1 ectodomain is cleaved, detectable in urine, and reflects renal damage. KIM-1 expression in human renal biopsies and its correlation with ur

  3. Kim C. Sturgess. Shakespeare and the American Nation.

    Directory of Open Access Journals (Sweden)

    Jean‑Louis Claret

    2006-04-01

    Full Text Available The front page of Kim C Sturgess’s recent book entitled Shakespeare and the American Nation is particularly mind‑teasing insofar as it represents the famous Droeshout engraving of the bard (it illustrated the front‑page of the 1623 edition of Shakespeare’s works standing out against a background that superimposes the head of the Statue of Liberty on the spangled banner. The starting point of Sturgess’s 234‑page demonstration endorsed by Cambridge University Press is a paradox that the Britis...

  4. A water-extract of the Korean traditional formulation Geiji-Bokryung-Hwan reduces atherosclerosis and hypercholesteremia in cholesterol-fed rabbits.

    Science.gov (United States)

    Kim, Beob-Jin; Kim, Yeon-Kye; Park, Won-Hwan; Ko, Jeong-Heon; Lee, Young-Choon; Kim, Cheorl-Ho

    2003-05-01

    Geiji-Bokryung-Hwan (GBH), a drug preparation consisting of five herbs of Cinnamomi Ramulus (Geiji), Poria Cocos (Bokryun), Mountan Cortex Radicis (Mokdanpi), Paeoniae Radix (Jakyak) and Persicae Semen (Doin), is a traditional Korean herbal medicine that is widely used in the treatment of atherosclerosis-related disorders. A water extract of GBH was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and inhibit low-density lipoprotein (LDL) oxidation more effectively than probucol, a well-known commercially available antioxidant. In order to evaluate the anti-atherogenic potential of this medication, New Zealand White (NZW) rabbits were fed a normal diet for 12 weeks, a high cholesterol diet, a high cholesterol diet containing 1% probucol or a high cholesterol diet containing 5% water-soluble extract of GBH. Both GBH and probucol reduced plasma cholesterol levels. LDLs from the GBH-treated group were more resistant to Cu(2+)-induced oxidation and contained more vitamin E than LDLs from the high cholesterol diet group. Endothelial damage, determined at week 6, was reduced by 55% in the GBH group (P<0.01). GBH treatment reduced an atherosclerotic area in the abdominal aorta by 58% (P<0.05) and cholesterol deposition in the thoracic aorta by 55% (P<0.05). The severity of atherosclerosis in the GBH group was significantly reduced after an adjustment using cholesterol exposure as an index of the cholesterol-lowering effect. On the other hand, diet-induced hyperlipidemic rabbits were given water extract of GBH in doses of 50 (Group B) and 200 mg/kg (Group C) and compared with controls (Group A). At 40 days after intervention in groups A, B and C, total and LDL cholesterol levels were significantly lowered (P<0.01). LDL/high density lipoprotein (HDL) ratio was also significantly decreased (P<0.01). This study concludes that the reduction in atherosclerosis by GBH relies not only on its cholesterol-lowering effect but also more heavily on its antioxidant

  5. Sexualidad violenta en el cine de Kim Ki-duk

    Directory of Open Access Journals (Sweden)

    Daniel Muñoz Ruiz

    2011-07-01

    Full Text Available En sus más de 110 años de vida el cine ha representado la sexualidad humana en todas sus modalidades y desde los más variados puntos de vista. El cine de Kim Ki-duk ha sorprendido y escandalizado al público por su crudeza y, a veces, excesiva violencia. El director surcoreano ha explorado a lo largo de su filmografía el tema del sexo siempre desde puntos de vista dramáticos y hasta truculentos. En sus películas la mayoría de las relaciones sexuales carecen de amor y afecto. Nunca son placenteras. La violación, la prostitución, la violencia de género y las frustraciones sexuales son temas recurrentes en su cine.

  6. Global Policing and the Case of Kim Dotcom

    Directory of Open Access Journals (Sweden)

    Darren Palmer

    2013-11-01

    Full Text Available In early 2012, 76 heavily armed police conducted a raid on a house in Auckland, New Zealand. The targets were Kim Dotcom, a German national with a NZ residency visa, and several colleagues affiliated with Megaupload, an online subscription-based peer-to-peer (P2P file sharing facility. The alleged offences involved facilitating unlawful file sharing and United States federal criminal copyright violations. Following the raid, several court cases provide valuable insights into emerging ‘global policing’ practices (Bowling and Sheptycki 2012 based on communications between sovereign enforcement agencies.  This article uses these cases to explore the growth of ‘extraterritorial’ police powers that operate ‘across borders’ (Nadelmann 1993 as part of several broader transformations of global policing in the digital age.

  7. Prediction of Potential Distribution of Quadrastichus erythrinae Kim in China

    Institute of Scientific and Technical Information of China (English)

    Zhang; Junzhong; Liu; Jianhong; Yang; Liying; Dan; Wenli

    2014-01-01

    Based on Maxent niche model and combined with ArcGIS,the suitable area range for Quadrastichus erythrinae Kim in China was predicted in the paper.The results showed that high suitable area for Q. erythrinae in China included most northeast coastal areas of Hainan Island,partial southern coastal area of Guangdong Province,partial northwestern coastal area and partial southeast coastal area of Taiwan Island; moderate suitable area included partial area of Hainan,some contiguous areas of Guangxi and Guangdong,most areas of Guangdong,partial area of Fujian and Taiwan; low suitable area included partial area from northwestern coast to inland of Hainan Island,west coastal area of Taiwan Island,most area in Guangxi,partial areas in Guangdong,Fujian and Yunnan.

  8. Izvori o riječkim povijesnim novinama 1813. - 1918.

    Directory of Open Access Journals (Sweden)

    Lea Lazzarich

    2009-11-01

    Full Text Available Nedostatak cjelovitog pregleda riječkih povijesnih novina u razdoblju od početaka novinskog tiska u Rijeci 1813. do 1918. godine prouzročio je brojne probleme u istraživanju riječke povijesti, i to kako pojedinih događaja tako i općih okolnosti. Takvo je stanje rezultiralo potrebom komparativnog analiziranja raspoloživih izvora o riječkim povijesnim novinama i, slijedom toga, izrade sustavnog pregleda svih objavljenih naslova u navedenom razdoblju. Tijekom stvaranja takvog pregleda izvori (pod tim se pojmom ovdje podrazumijevaju radovi, ponajprije bibliografije, koji se bave riječkim povijesnim novinama su sustavno i komparativno analizirani te su provjereni podaci o svakom naslovu, ali i sami naslovi koji nisu transparentno navedeni u svim izvorima, s ciljem stvaranja popisa novina prema definiciji i obilježjima. Time je osigurana platforma za daljnji rad i riješen barem dio nedoumica u istraživanju riječkih povijesnih novina. Doprinos istraživanja su novi, dopunjeni i često izmijenjeni podaci o naslovu, impresumu ili periodičnosti pojedinih novina (uz napomenu da se periodičnost nerijetko mijenjala tijekom godina, koji su od ključne važnosti kako u knjižničarskom tako i u povijesnoistraživačkom smislu. Ne prejudicira se da je istraživanje konačno i zatvoreno, već se naglašava nužnost daljnjeg propitivanja podataka o pojedinim povijesnim novinama, uzimajući pritom u obzir činjenicu da je posljednje sustavno istraživanje provođeno prije pedesetak godina.

  9. A Multi-Agent Mah Jong Playing System: Towards Real-Time Recognition of Graphic Units in Graphic Representations

    Directory of Open Access Journals (Sweden)

    H. Achten

    2003-01-01

    Full Text Available In architectural design, sketching is an important means to explore the first conceptual developments in the design process. It is necessary to understand the conventions of depiction and encoding in sketches and drawings if we want to support the architect in the sketching activity. The theory of graphic units provides a comprehensive list of conventions of depiction and encoding that are widely used among architects. These graphic units form useful building blocks to understand design drawings. We investigate whether it is possible to build a system that can recognize graphic units. The technology we are looking at is multi-agent systems. It was chosen for the following reasons: agents can specialize in graphic units, a multi-agent system can deal with ambiguity through negotiation and conflict resolution, and multi-agent systems function in dynamically changing environments. Currently there is no general approach or technology available for multi-agent systems. Therefore, in our research we first set out to make such a multi-agent system. In order to keep the complexity low, we first aim to make a system that can do something simple: playing Mah Jong solitary. The Mah Jong solitary system shares the following important features with a multi-agent system that can recognize graphic units: (1 specialized agents for moves; (2 negotiation between agents to establish the best move; (3 a dynamically changing environment; and (4 search activity for more advanced strategies. The paper presents the theoretical basis of graphic units and multi-agents systems, followed by a description of the multi-agent framework and its implementation. A number of systems that can play Mah Jong at various degrees of competence and accordingly degrees of complexity of multi-agent system, are distinguished. Finally, the paper demonstrates how the findings are informative for a system that can recognize graphic units.

  10. An Efficient Image Encryption Scheme Based on a Peter De Jong Chaotic Map and a RC4 Stream Cipher

    Science.gov (United States)

    Hanchinamani, Gururaj; Kulkarni, Linganagouda

    2015-09-01

    Security is a vital issue in communication and storage of the images and encryption is one of the ways to ensure the security. This paper proposes an efficient image encryption scheme based on a Peter De Jong chaotic map and a RC4 stream cipher. A Peter De Jong map is employed to determine the initial keys for the RC4 stream generator and also during permutation stage. The RC4 stream generator is utilized to generate the pseudo random numbers for the pixel value rotation and diffusion operations. Each encryption round is comprised of three stages: permutation, pixel value rotation and diffusion. The permutation is based on scrambling the rows and columns, in addition, circular rotations of the rows and columns in alternate orientations. The second stage circularly rotates each and every pixel value by utilizing M × N pseudo random numbers. The last stage carries out the diffusion twice by scanning the image in two different ways. Each of the two diffusions accomplishes the diffusion in two orientations (forward and backward) with two previously diffused pixels and two pseudo random numbers. The security and performance of the proposed method is assessed thoroughly by using key space, statistical, differential, entropy and performance analysis. Moreover, two rounds of the call to the encrypt function provide the sufficient security. The experimental results show that the proposed encryption scheme is computationally fast with high security.

  11. Een nieuwe kijk op het werk en de loopbaan van jonge werknemers [A new perspective on the work and career of young employees

    NARCIS (Netherlands)

    Akkermans, J.; Brenninkmeijer, V.; Blonk, R.W.B.

    2015-01-01

    In dit artikel geven we een overzicht van ons onderzoek naar het welzijn en de loop‐baanontwikkeling van jonge werknemers die de transitie naar de arbeidsmarkt gaan maken of recent gemaakt hebben. We bespreken onze bevindingen op het gebied van werkkenmerken die belangrijk zijn voor jongeren om hen

  12. Konrad Ottenheym and Krista De Jonge (eds., The Low Countries at the Crossroads. Netherlandish Architecture as an Export Product in Early Modern Europe (1480-1680

    Directory of Open Access Journals (Sweden)

    Oliver Kik

    2015-12-01

    Full Text Available Book review of: Konrad Ottenheym & Krista De Jonge (eds., The Low Countries at the Crossroads. Netherlandish Architecture as an Export Product in Early Modern Europe (1480-1680, (Architectura Moderna, vol. VIII. Turnhout, Brepols, 2013. 514 pp. ISBN 978-2-503-54333-8. € 130,00.

  13. On some results of Bump-Choie and Choie-Kim

    CERN Document Server

    Hundley, Joseph

    2011-01-01

    This paper is motivated by a 2001 paper of Choie and Kim and a 2006 paper of Bump and Choie. The paper of Choie and Kim extends an earlier result of Bol for elliptic modular forms to the setting of Siegel and Jacobi forms. The paper of Bump and Choie provides a representation theoretic interpretation of the phenomenon, and shows how a natural generalization of Choie and Kim's result on Siegel modular forms follows from a natural conjecture regarding (g,K)-modules. In this paper, it is shown that the conjecture of Bump and Choie follows from work of Boe. A second proof which is along the lines of the proof given by Bump and Choie in the genus 2 case is also included, as is a similar treatment of the result of Choie and Kim on Jacobi forms.

  14. His Excellency Mr Ian de Jong, Ambassador, Permanent Representative of the Kingdom of the Netherlands to the United Nations Office in Geneva

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Visit of His Excellency Mr Ian de Jong, Ambassador, Permanent Representative of the Kingdom of the Netherlands to the United Nations Office in Geneva, June 2003. From left to right: Dr Albert Ijspeert, Deputy Leader, Magnet and electrical systems Group, Accelerator Technology Division; Mr Maarten Wilbers, Legal Service; Prof. Cecilia Jarlskog, Adviser to the Director-General for Member State Relations; Mr Jan van der Boon, Director of Administration; His Excellency Mr Ian de Jong, Ambassador, Permanent Representative of the Kingdom of the Netherlands to the United Nations Office in Geneva; Prof. Frank Linde, NIKHEF; Dr Lucie Linssen Experimental Physics Division, Technical Assistance Group and Mr C. J. van Riel, Ministry of Education, Culture and Science, Netherlands, Dutch Delegate to Council and Finance Committee.

  15. Using the De Jong Gierveld Loneliness Scale With Early Adolescents: Factor Structure, Reliability, Stability, and External Validity.

    Science.gov (United States)

    Grygiel, Paweł; Humenny, Grzegorz; Rębisz, Sławomir

    2016-12-08

    The present investigation is the first examination of the factor structures, reliability, external validity, longitudinal invariance, and stability of the De Jong Gierveld Loneliness Scale (DJGLS), as used with early adolescents. It is based on a two-wave, large, representative sample of Polish primary school pupils. The results demonstrate that the model most reflective of the factor structure of the DJGLS is the bifactor model, which assumes the occurrence of one, highly reliable, general factor (overall sense of loneliness) and two, relatively irrelevant, subfactors. Essential unidimensionality (the general factor accounting for three fourth of the common variance) suggest that the interpretation of the subfactors over and above the general factor is inappropriate. The longitudinal confirmatory factor analysis indicated that the bifactor structure of the DJGLS is invariant over time. Correlations with self-rated loneliness, sociometric acceptance/rejection, social self-efficacy, identification with class group, family structure, and gender provide support for the validity of the DJGLS. This implies that it could be used as a measure of loneliness in adolescence, which does not involve references to the school context, making it possible to conduct studies that go beyond school period and compare the intensity of the feeling of loneliness in that group with other age groups.

  16. Kim model for flux-pinning-induced stress in a long cylindrical superconductor

    Science.gov (United States)

    Zeng, Jun; Wang, Xiaogui; Wu, Huaping; Xue, Feng; Zhu, Jun

    2016-07-01

    In this work, the flux-pinning-induced stress distribution in a circular cylinder of high-temperature superconductors is studied by adopting the Kim critical state model to describe the relationship between the magnetic flux density and induced current. Based on the plane strain approach, the analytic expressions of the radial and hoop stress in the cylinder are derived for the zero-field cooling and field cooling magnetization processes. It is shown that the stress distributions depend on the activation processes and the values of the dimensionless parameter p in the Kim model, and the overall maximums of the stresses appear at or near the center of the cylinder where cracking may be most likely initiated. In addition, the Kim model has wider applicability than the Bean model, and the influence of p on the stress depends on the activation process. Generally speaking, these results may be useful for understanding the magnetoelastic problem in practical application of bulk superconductors.

  17. [The medical treatment of Kim Phúc at the BG Unfallklinik Ludwigshafen].

    Science.gov (United States)

    Kiefer, J; Daigeler, A; Lehnhardt, M

    2012-08-01

    The Vietnam War was a military conflict in Vietnam during the Cold War that followed the First Indochina War. This war was fought between North Vietnam, supported by its communist allies, and the government of South Vietnam, supported by the USA and other anti-communist countries. Kim Phúc is the child depicted in the Pulitzer Prize winning photograph taken on June 8, 1972 by AP photographer Nick Út. The iconic photo shows her at about nine years of age running naked on a road amid the chaos after being severely burned by a napalm attack. After 14 months of hospital stay and 17 surgical procedures Kim Phúc was able to return home. Since then, she was used as a propaganda symbol by the communist government of Vietnam. To continue her studies, Kim was granted permission to move to Cuba where she met her future husband. However, the sequelae of her burn wounds affected her everyday life enormously. In 1984, with the support of the international aid organization "terre des hommes" and the German magazine "STERN", Kim Phúc got the opportunity to meet and get treated by Professor Zellner. Professor Peter Rudolph Zellner was the first chief of the Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, and one of the founder members of the German Society of Plastic Surgeons. The reconstructive surgeries provide Kim Phúc an almost normal life. Later on, she was involved in international aid organizations; she was named a UNESCO Goodwill Ambassador and she was awarded several honorary Doctorates of Law. Kim Phúc became a Canadian citizen. Today, she lives with her husband and two children in Ontario, Canada. © Georg Thieme Verlag KG Stuttgart · New York.

  18. Lessons learned from 15 years of KIMS and 5 years of ACROSTUDY

    DEFF Research Database (Denmark)

    Luger, Anton; Feldt-Rasmussen, Ulla; Abs, Roger;

    2011-01-01

    BACKGROUND: Pharmacoepidemiological surveys provide a valuable contribution to the continued monitoring of drug-related effects in patients with rare disorders. One of the earliest examples of this type of survey is KIGS (Pfizer International Growth Study Database), which has monitored the safety...... and effectiveness of growth hormone (GH) therapy in GH-deficient children since its inception in 1987. Following closely in the footsteps of KIGS is KIMS (Pfizer International Metabolic Database). As of 2009, KIMS has been collecting data on the long-term safety and clinical outcomes of GH replacement in GH...

  19. Urinary KIM-1 and AQP-1 in patients with clear renal cell carcinoma: Potential noninvasive biomarkers

    Directory of Open Access Journals (Sweden)

    Mijušković Mirjana

    2016-01-01

    Full Text Available Background/Aim. Kidney injury molecule-1 (KIM-1 and aquaporin-1 (AQP-1 are potential early urinary biomarkers of clear renal cell carcinoma (cRCC. The aim of this study was to ascertain relationship between the urine concentrations KIM-1 and AQP-1 with tumor size, grade, pT stage and type of operation (radical or partial nephrectomy in patients with cRCC. Methods. Urinary concentrations of urinary KIM-1 (uKIM-1 and urinary AQP-1 (uAQP-1 were determined by commercially available ELISA kits. The analysis included 40 patients undergoing partial or radical nephrectomy for cRCC and 40 age- and sex-matched healthy adult volunteers. Results. The median preoperative concentrations of KIM-1 in the cRCC group [0.724 ± 1.120 ng/mg urinary creatinine (Ucr] were significantly greater compared with controls (healthy volunteers (0.210 ± 0.082 ng/mgUcr (p = 0.0227. Postoperatively, uKIM-1 concentration decreased significantly to control values (0.177 ± 0.099 ng/mgUcr vs 0.210 ± 0.082 ng/mgUcr, respectively. The size, grade and stage of tumor were correlated positively with preoperative uKIM-1 concentrations. Contrary to these results, concentrations of uAQP-1 in the cRCC group were significantly lower (0.111 ± 0.092 ng/mgUcr compared with the control group (0.202 ± 0.078 ng/mgUcr (p = 0.0014. Postoperatively, the concentrations of uAQP-1 increased progressively up to control values, approximately. We find no significant correlation between preoperative uAQP-1 concentrations and tumor size, grade and stage. Conclusion. uKIM-1 was found to be a reliable diagnostic marker of cRCC, based on its significantly increased values before and decreased values after the nephrectomy. [Projekat Ministarstva nauke Republike Srbije, br. III41018

  20. PREVALENCE OF NEURAL TUBE DEFECTS IN KIMS KARAD, 2012-2013 EFFECTIVENESS AND IMPACT OF PRENATAL DIAGNOSIS

    Directory of Open Access Journals (Sweden)

    Sanjaykumar

    2014-11-01

    Full Text Available : OBJECTIVE: To determine Prevalence of NEURAL TUBE DEFECT in tertiary care center (KIMS Karad during July 2012-July 2013. MATERIAL AND METHODS: Patients referred to KIMS as NTD, Booked Patients diagnosed in KIMS as having neural tube defect based on ultrasound findings. RESULTS: Total prevalence of neural tube defect in KIMS from July 2012-July 2013 was 8.2/1000 births. Prevalence of different types of NTD-Anencephaly was 2.8 and spina bifida was 7.4. CONCLUSION: Aim of this study is to create awareness of NTD in order to prevent NTD by measures like periconceptional folic acid supplementation.

  1. Arhitektuurimuuseum vaatab Aasiasse / Kim Sung Hong ; intervjueerinud Karin Hallas-Murula

    Index Scriptorium Estoniae

    Kim Sung Hong

    2009-01-01

    Näituse kuraatori Kim Sung Hongiga 21. aprillini Eesti Arhitektuurimuuseumis avatud Lõuna-Korea kaasaegse arhitektuuri näitusest "Megacity network" ("Megalinna võrgustik"), Korea arhitektuurist, arhitektidest, muinsuskaitsest ja avalikust ruumist. Näituse kujundas Hwang Doo Jin

  2. Kim 3: an Ultra-faint Star Cluster in the Constellation of Centaurus

    CERN Document Server

    Kim, Dongwon; Mackey, Dougal; Da Costa, Gary S; Milone, Antonino P

    2015-01-01

    We report the discovery of an ultra-faint star cluster in the constellation of Centaurus. This new stellar system, Kim 3, features a half light radius of $r_{h}=2.29^{+1.28}_{-0.52}$ pc and a total luminosity of $M_{V}=+0.7\\pm0.3$. Approximately 26 stars are identified as candidate member stars down to four magnitudes below the main-sequence turn-off, which makes Kim 3 the least luminous star cluster known to date. The compact physical size and extreme low luminosity place it close to faint star clusters in the size-luminosity plane. The stellar population of Kim 3 appears to be relatively young ($9.5^{+3.0}_{-1.7}$ Gyr) and metal-poor ([Fe/H]$=-1.6^{+0.45}_{-0.30}$) at a heliocentric distance of $15.14^{+1.00}_{-0.28}$ kpc. The cluster lacks a well-defined center and a small but prominent group of stars consistent with the Kim 3 isochrone is present approximately 9.7 pc in projection south of the cluster center. Both are signs of the cluster being in the final stage of tidal disruption.

  3. Ever Searching for Better Living——Tan Sri Lee Kim Yew and his CHHB Group

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Visionary Entrepreneur There have been many spectacular feats and achievements by Malaysians in the last two decade,but none as uneXpected and hard-fought as the rise of Tan Sri Lee Kim Yew,Group Managing Director and Founder of CHHB.

  4. A Misleading Review of Response Bias: Comment on McGrath, Mitchell, Kim, and Hough (2010)

    Science.gov (United States)

    Rohling, Martin L.; Larrabee, Glenn J.; Greiffenstein, Manfred F.; Ben-Porath, Yossef S.; Lees-Haley, Paul; Green, Paul; Greve, Kevin W.

    2011-01-01

    In the May 2010 issue of "Psychological Bulletin," R. E. McGrath, M. Mitchell, B. H. Kim, and L. Hough published an article entitled "Evidence for Response Bias as a Source of Error Variance in Applied Assessment" (pp. 450-470). They argued that response bias indicators used in a variety of settings typically have insufficient data to support such…

  5. Dlaczego Korea?czycy z P??nocy akceptuj? w?adz? Kim?w?

    OpenAIRE

    Zdenkowska, Marcelina

    2016-01-01

    Celem artyku?u jest przedstawienie dw?ch popularnych teorii dotycz?cych problemu w?adzy w Korei P??nocnej. Analizie zostan? poddane tezy: konfucjanistyczna i nacjonalistyczna. Podj?te tu rozwa?ania maj? na celu odpowiedzie? na pytanie dlaczego Korea?czycy z P??nocy akceptuj? w?adz? Kim?w? Marcelina Zdenkowska

  6. KIM 3: An Ultra-faint Star Cluster in the Constellation of Centaurus

    Science.gov (United States)

    Kim, Dongwon; Jerjen, Helmut; Mackey, Dougal; Da Costa, Gary S.; Milone, Antonino P.

    2016-04-01

    We report the discovery of an ultra-faint star cluster in the constellation of Centaurus. This new stellar system, Kim 3, features a half-light radius of {r}h={2.29}-0.52+1.28 pc and a total luminosity of MV = +0.7 ± 0.3. Approximately 26 stars are identified as candidate member stars down to four magnitudes below the main-sequence turn-off, which makes Kim 3 the least luminous star cluster known to date. The compact physical size and extreme low luminosity place it close to faint star clusters in the size-luminosity plane. The stellar population of Kim 3 appears to be relatively young ({9.5}-1.7+3.0 Gyr) and metal-poor ([Fe/H]\\quad =\\quad -{1.6}-0.30+0.45) at a heliocentric distance of {15.14}-0.28+1.00 kpc. The cluster lacks a well-defined center, and a small but prominent group of stars consistent with the Kim 3 isochrone is present approximately 9.7 pc in projection south of the cluster center. Both are signs of the cluster being in the final stage of tidal disruption.

  7. Arhitektuurimuuseum vaatab Aasiasse / Kim Sung Hong ; intervjueerinud Karin Hallas-Murula

    Index Scriptorium Estoniae

    Kim Sung Hong

    2009-01-01

    Näituse kuraatori Kim Sung Hongiga 21. aprillini Eesti Arhitektuurimuuseumis avatud Lõuna-Korea kaasaegse arhitektuuri näitusest "Megacity network" ("Megalinna võrgustik"), Korea arhitektuurist, arhitektidest, muinsuskaitsest ja avalikust ruumist. Näituse kujundas Hwang Doo Jin

  8. Migrant Writing in Quebec : Female Mobility in Kim Thúy’s Ru

    NARCIS (Netherlands)

    den Toonder, Jeanette; Averis, Kate; Hollis-Touré, Isabel

    2016-01-01

    This chapter presents the experience of mobility as one of duality, an experience of both rupture and continuity as expressed in the poetic prose of Kim Thúy, resident in Quebec since her departure from her native Vietnam at ten years of age. Describing an experience of fragmented simultaneity that

  9. From isolated GH deficiency to multiple pituitary hormone deficiency: an evolving continuum - a KIMS analysis

    DEFF Research Database (Denmark)

    Klose, M.; Jonsson, B.; Abs, R.;

    2009-01-01

    with organic AO-GHD, who were GH naive prior to entry into the Pfizer International Metabolic Database (KIMS; 283 (7%) IGHD, 3827 MPHD). The effect of GH replacement after 2 years was assessed in those with available follow-up data (133 IGHD, 2207 MPHD), and development of new deficiencies in those...

  10. The first clinical treatment with kilovoltage intrafraction monitoring (KIM): A real-time image guidance method

    Energy Technology Data Exchange (ETDEWEB)

    Keall, Paul J., E-mail: paul.keall@sydney.edu.au; O’Brien, Ricky; Huang, Chen-Yu [Radiation Physics Laboratory, Sydney Medical School, University of Sydney, Camperdown, New South Wales 2006 (Australia); Aun Ng, Jin [Radiation Physics Laboratory, Sydney Medical School, University of Sydney, Camperdown, New South Wales 2006, Australia and School of Physics, University of Sydney, Camperdown, New South Wales 2006 (Australia); Colvill, Emma [Radiation Physics Laboratory, Sydney Medical School, University of Sydney, Camperdown, New South Wales 2006, Australia and Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales 2065 (Australia); Rugaard Poulsen, Per; Fledelius, Walther [Department of Oncology, Aarhus University Hospital, 8000 Aarhus C, Denmark and Institute of Clinical Medicine, Aarhus University, 8000 Aarhus C (Denmark); Juneja, Prabhjot; Booth, Jeremy T. [School of Physics, University of Sydney, Camperdown, New South Wales 2006, Australia and Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales 2065 (Australia); Simpson, Emma; Bell, Linda; Alfieri, Florencia; Eade, Thomas; Kneebone, Andrew [Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales 2065 (Australia)

    2015-01-15

    Purpose: Kilovoltage intrafraction monitoring (KIM) is a real-time image guidance method that uses widely available radiotherapy technology, i.e., a gantry-mounted x-ray imager. The authors report on the geometric and dosimetric results of the first patient treatment using KIM which occurred on September 16, 2014. Methods: KIM uses current and prior 2D x-ray images to estimate the 3D target position during cancer radiotherapy treatment delivery. KIM software was written to process kilovoltage (kV) images streamed from a standard C-arm linear accelerator with a gantry-mounted kV x-ray imaging system. A 120° pretreatment kV imaging arc was acquired to build the patient-specific 2D to 3D motion correlation. The kV imager was activated during the megavoltage (MV) treatment, a dual arc VMAT prostate treatment, to estimate the 3D prostate position in real-time. All necessary ethics, legal, and regulatory requirements were met for this clinical study. The quality assurance processes were completed and peer reviewed. Results: During treatment, a prostate position offset of nearly 3 mm in the posterior direction was observed with KIM. This position offset did not trigger a gating event. After the treatment, the prostate motion was independently measured using kV/MV triangulation, resulting in a mean difference of less than 0.6 mm and standard deviation of less than 0.6 mm in each direction. The accuracy of the marker segmentation was visually assessed during and after treatment and found to be performing well. During treatment, there were no interruptions due to performance of the KIM software. Conclusions: For the first time, KIM has been used for real-time image guidance during cancer radiotherapy. The measured accuracy and precision were both submillimeter for the first treatment fraction. This clinical translational research milestone paves the way for the broad implementation of real-time image guidance to facilitate the detection and correction of geometric and

  11. Urinary Kidney Injury Molecule-1 (KIM-1 in Early Diagnosis of Acute Kidney Injury in Pediatric Critically Ill

    Directory of Open Access Journals (Sweden)

    Irma Lestari Paramastuty

    2016-04-01

    Full Text Available Acute kidney injury (AKI often associated with a high hospital morbi-mortality rate in the intensive care unit patients. Kidney injury molecule-1 (KIM-1, has many characteristics of ideal biomarker for kidney injury. The aim of this study was to compared the temporal pattern of elevation urinary KIM-1 level following critically ill children with SCr as standart biomarker of AKI. Prospective analytic observational study was conducted during October to March 2014 in the Saiful Anwar General Hospital and Physiology Laboratory Brawijaya University. There were 13 critically ill as subjects. SCr and KIM-1 levels from all subjects were measured three times ( at admission, after 1st and 6th hour. Subjects were devided into AKI - non-AKI groups by SCr level and survivor - non survivor group at the and of the observations. Results showed that there were significantly increased levels of KIM-1 in the AKI and non-AKI and survivor-non survivor group at time point. However, we found that delta KIM-1 at time point increased significant in non AKI group and survivor group. KIM-1 at admission can diagnosed AKI in critically ill children. We conclude that urinary KIM-1 is a sensitive non-invasive biomarker to diagnosed acute kidney injury in critically ill children. Increase level of KIM-1 by time shows protective and good outcome in critically ill children.

  12. Contactdag Jonge vorsers overzee

    Directory of Open Access Journals (Sweden)

    Royal Academy for Overseas Sciences

    2014-01-01

    Full Text Available Afin d'identifier les principaux aliments d'origine animale consommés par les populations vivant dans la concession 039/11 de la Société de Développement Forestier (SODEFOR, République Démocratique du Congo et de spécifier les déterminants de la consommation, 120 ménages répartis dans 3 villages (Taketa, Ikala 1 et Mombele et la base-vie de Nteno ont été enquêtés pendant 30 jours. Les résultats montrent que la viande de brousse représente 72,00% du nombre de repas, suivi du poisson (24,00% et enfin des produits d'élevage (3,10%. Au total, 30 espèces animales dont 4 légalement interdites de chasse ont été identifiées, pour une biomasse totale de 1235 kg. Les mammifères constituent 97,00% des animaux consommés avec une dominance des artiodactyles (71,60%, des primates (15,40% et des rongeurs (9,10%. Les céphalophes, les cercopithèques et l'athérure sont les plus représentés. Les actes de consommation sont guidés par la disponibilité du produit, le goût et les habitudes alimentaires. La majorité des ménages s'approvisionne auprès d'intermédiaires essentiellement sous forme de morceaux d'animaux. Cette étude suggère un suivi à long terme de la chasse assorti d'une évaluation de l'abondance des espèces animales afin de guider la SODEFOR dans la prise des décisions.

  13. Experimental study for Yuen-Kim protocol of quantum key distribution with unconditional secure

    OpenAIRE

    Hirota, O.; Kato, K; Sohma, M.

    2002-01-01

    In this report, we simulate practical feature of Yuen-Kim protocol for quantum key distribution with unconditional secure. In order to demonstrate them experimentally by intensity modulation/direct detection(IMDD) optical fiber communication system, we use simplified encoding scheme to guarantee security for key information(1 or 0). That is, pairwise M-ary intensity modulation scheme is employed. Furthermore, we give an experimental implementation of YK protocol based on IMDD.

  14. Kimi mantlipärija sai mõjukatele ametipostidele / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2010-01-01

    Põhja-Korea pealinnas toimunud Tööliste Partei kongressil määrati riigi liidri Kim Jong-ili noorim poeg Kim Jong-un kesksõjakomisjoni aseesimeheks ja keskkomitee liikmeks. Poliitbüroosse määrati alternatiivliikmena Kim Jong-ili õe abikaasa Chang Song-taek

  15. Kimi mantlipärija sai mõjukatele ametipostidele / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2010-01-01

    Põhja-Korea pealinnas toimunud Tööliste Partei kongressil määrati riigi liidri Kim Jong-ili noorim poeg Kim Jong-un kesksõjakomisjoni aseesimeheks ja keskkomitee liikmeks. Poliitbüroosse määrati alternatiivliikmena Kim Jong-ili õe abikaasa Chang Song-taek

  16. Un esempio di 'decodifica iperbolica'. La ricontestualizzazione narrativa di una scena di simposio greco nel romanzo Il salto di Saffo di Erica Jong

    Directory of Open Access Journals (Sweden)

    Gloria Larini

    2012-12-01

    Full Text Available Lo studio sonda l'unica scena di simposio greco presente nel romanzo Il salto di Saffo di Erica Jong. Si intendono scoprire i rapporti tra la resa linguistica dei frammenti saffici e alcaici operata dalla scrittrice ed il testo originale. Si è effettuata una comparazione con metodo linguistico-filologico tra i testi antichi e il romanzo, sondando preliminarmente, attraverso una analisi semantica intratestuale, i riferimenti classici ivi contenuti. Lo studio individua tre principali direzioni di decodifica attivate dalla Jong: riduzioni e/o aggiunte, variazioni linguistiche rispetto ai frammenti greci;  invenzioni storico-biografiche sui personaggi che ne 'mistificano' il senso;  adattamento della storia alle informazioni dei frammenti attraverso una loro lettura inferenziale.  L'articolo 'scopre' una nuova forma di decodifica da testo letterario a testo letterario che ho definito 'iperbolica', con un neologismo che mette in evidenza la complessità del passaggio sincrono, non frequente, dall'antico al moderno e da un genere all'altro, mettendo in evidenza contaminazioni e pastiche di un procedimento non proprio politically correct, sebbene dimostri l'attualità dei temi della letteratura greca antica. AbstractTitle: “An example of ‘hyperbolic decoding’. Reframing the narrative of a greek symposium scene in the Erica Jong’s novel Sappho’s Leap”. The study is about the only greek symposium scene in the Erica Jong’s novel Sappho’s Leap. We intend to explore the relationship between linguistic rendering of greek fragments by the author and the original texts. We compare, through a linguistic-philological method, the ancient greek text and the novel through a semantic analysis intratextual and intertextual. The study identifies three main directions of decoding activated by Jong: linguistic reductions and / or additions in greek fragments; historical and biographical inventions about the characters, that ‘mistify’ the

  17. Phenotypic characterization of OmpX, an Ail homologue of Yersinia pestis KIM.

    Science.gov (United States)

    Kolodziejek, Anna M; Sinclair, Dylan J; Seo, Keun S; Schnider, Darren R; Deobald, Claudia F; Rohde, Harold N; Viall, Austin K; Minnich, Scott S; Hovde, Carolyn J; Minnich, Scott A; Bohach, Gregory A

    2007-09-01

    The goal of this study was to characterize the Yersinia pestis KIM OmpX protein. Yersinia spp. provide a model for studying several virulence processes including attachment to, and internalization by, host cells. For Yersinia enterocolitica and Yersinia pseudotuberculosis, Ail, YadA and Inv, have been implicated in these processes. In Y. pestis, YadA and Inv are inactivated. Genomic analysis of two Y. pestis strains revealed four loci with sequence homology to Ail. One of these genes, designated y1324 in the Y. pestis KIM database, encodes a protein designated OmpX. The mature protein has a predicted molecular mass of 17.47 kDa, shares approximately 70 % sequence identity with Y. enterocolitica Ail, and has an identical homologue, designated Ail, in the Y. pestis CO92 database. The present study compared the Y. pestis KIM6(+) parental strain with a mutant derivative having an engineered disruption of the OmpX structural gene. The parental strain (and a merodiploid control strain) expressed OmpX at 28 and 37 degrees C, and the protein was detectable throughout all phases of growth. OmpX was required for efficient adherence to, and internalization by, cultured HEp-2 cell monolayers and conferred resistance to the bactericidal effect of human serum. Deletion of ompX resulted in a significantly reduced autoaggregation phenotype and loss of pellicle formation in vitro. These results suggest that Y. pestis OmpX shares functional homology with Y. enterocolitica Ail in adherence, internalization into epithelial cells and serum resistance.

  18. Kim e a literatura colonial de língua inglesa

    Directory of Open Access Journals (Sweden)

    Vanderlei J. Zacchi

    2016-01-01

    Full Text Available Kim é não apenas um dos livros mais importantes de Rudyard Kipling, mas ocupa também posição de destaque na literatura de língua inglesa. Foi lançado em 1901, quando a Índia, onde se passa o romance, era ainda uma possessão britânica e doze anos após Kipling, tendo nascido na Índia, haver migrado para a Inglaterra. As relações entre os personagens orientais e britânicos no romance sugerem uma visão estereotipada das diferenças raciais e culturais. A aná- lise dessas relações será feita, em primeiro lugar, a partir de uma contextualização da literatura colonial de língua inglesa. Kim se insere numa segunda etapa dessa literatura, na qual predominava um ponto de vista predominantemente britânico e que buscava afirmar a legitimidade do império. E, em segundo lugar, a partir do conceito de orientalismo, conforme desenvolvido por Edward Said (1995. Esse conceito demonstra como os ocidentais fazem uso de sínteses e estereótipos para descrever o Oriente e conceber visões autorizadas sobre ele. Palavras-chave: Rudyard Kipling; literatura colonial; orientalismo

  19. Lessons learned from 15 years of KIMS and 5 years of ACROSTUDY

    DEFF Research Database (Denmark)

    Luger, Anton; Feldt-Rasmussen, Ulla; Abs, Roger

    2011-01-01

    BACKGROUND: Pharmacoepidemiological surveys provide a valuable contribution to the continued monitoring of drug-related effects in patients with rare disorders. One of the earliest examples of this type of survey is KIGS (Pfizer International Growth Study Database), which has monitored the safety......, pharmacoepidemiological surveys such as KIMS and ACROSTUDY provide valuable information on the safety and effectiveness of treatment with GH replacement and pegvisomant in the real world.......-deficient adults for 15 years. Approximately 5 years ago, the ACROSTUDY database was established to monitor the long-term safety and effectiveness of pegvisomant in patients with acromegaly. CONCLUSIONS: By collecting data on the treatment of relatively rare conditions in routine clinical practice...

  20. Vapor-liquid phase equilibria of water modelled by a Kim-Gordon potential

    Energy Technology Data Exchange (ETDEWEB)

    Maerzke, K A; McGrath, M J; Kuo, I W; Tabacchi, G; Siepmann, J I; Mundy, C J

    2009-03-16

    Gibbs ensemble Monte Carlo simulations were carried out to investigate the properties of a frozen-electron-density (or Kim-Gordon, KG) model of water along the vapor-liquid coexistence curve. Because of its theoretical basis, such a KG model provides for seamless coupling to Kohn-Sham density functional theory for use in mixed quantum mechanics/molecular mechanics (QM/MM) implementations. The Gibbs ensemble simulations indicate rather limited transferability of such a simple KG model to other state points. Specifically, a KG model that was parameterized by Barker and Sprik to the properties of liquid water at 300 K, yields saturated vapor pressures and a critical temperature that are significantly under- and over-estimated, respectively.

  1. Lengua, escritura y arraigo en la obra de Kim Thúy

    Directory of Open Access Journals (Sweden)

    Lidia González Menéndez

    2014-04-01

    Full Text Available The writing of Kim Thúy, Quebec au thor originally from Vietnam, represents a place of attachment against exile. The protagonist in Ru(2009, her first work, rebuilds herself and builds her relationship with others in an autobiographical story where the tragic journey of the boat people articulates an almost intimate personal chronicle, which does not focus on exile but on rebirth and reconciliation. À toi(2011, which was written in tandem with Pascal Janovjak, author of Swiss nationality and French-Slovakian descent, is a hybrid work mixing epistolary novel and correspondence between writers across an ocean and six time zones. Even while staging the nomadism and exile of the co-authors, this work highlights the roots and represents writing as a celebration of words.

  2. KIM-1、CC16在急性肾/肺损伤临床诊断中的意义%The significance of KIM-1 、CC16 in acute kidney injury and acute lung injure

    Institute of Scientific and Technical Information of China (English)

    申晓丽; 周巧玲; 王祺

    2014-01-01

    目的 观察肾损伤分子-1(kidney injury molecule 1,KIM-1)与Clara细胞分泌蛋白(Clara cell secretionprotein,CCSP/CC16)在急性肾损伤(Acute Kidney Injury,AKI)合并急性肺损伤(Acute Lung Injury,ALI)患者体内的变化,探讨其在急性肾/肺损伤临床诊断中的意义.方法 入选本院确诊为AKI的患者纳入AKI组(25例),确诊为ALI的患者纳入ALI组(15例),确诊为AKI合并ALI的患者纳入AKI+ALI组(25例),与之年龄、性别、民族相匹配的非吸烟健康志愿者作为正常对照组(23例),采用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测尿液KIM-1、尿液CC16和血浆KIM-1、血浆CC16的水平,用比色法检测尿N-乙酰-β-D-氨基葡萄糖苷酶(N-acetyl-beta-D-glucosaminidase,NAG),整理四组所有研究资料利用统计学方法进行综合分析.结果 与正常非吸烟对照组相比,AKI组的尿NAG酶、尿KIM-1、血浆KIM-1和血浆CC16水平均显著升高,差异有统计学意义(P<0.05);ALI组的尿CC16和血浆CC16水平均显著升高,差异有统计学意义(P <0.05);AKI+ALI组的尿NAG酶、尿KIM-1、血浆KIM-1、尿CC16和血浆CC16水平均显著升高,差异有统计学意义(P<0.05).直线相关分析显示:AKI患者的尿KIM-1水平与尿NAG呈显著正相关关系(r=0.493,P<0.01),血浆KIM-1水平与尿NAG无直线相关关系(r =0.276,P>0.05).ALI患者的尿CC16、血浆CC16与氧合指数均呈显著负相关关系(r=0.460,P<0.01;r=0.468,P<0.01).AKI合并ALI患者的尿KIM-1、血浆KIM-1与尿CC16、血浆CC16均呈显著正相关关系(P<0.05).ROC曲线分析提示:在AKI诊断中,尿KIM-1曲线下面积为0.781(95% CI:0.688 ~0.875,P<0.01);血浆KIM-1曲线下面积为0.988(95% CI:0.000~1.000,P<0.01);尿NAG酶曲线下面积为0.798 (95%CI:0.708~0.888,P<0.01).在ALI诊断中,尿CC16曲线下面积为1.000(95% CI:1.000 ~1.000,P<0.01);血浆CC16曲线面积为0.849(95% CI:0.764~0.935,P<0.01).结论 AKI时尿NAG、尿KIM

  3. Logistički kontroling u savremenim logističkim sistemima / Logistic controlling in modern logistic systems

    Directory of Open Access Journals (Sweden)

    Aleksandar Cakić

    2003-01-01

    Full Text Available U raduje data definicija logističkog kontrolinga u logističkim sistemima Prikazane su njegove osnovne funkcije, kao i mesto i uloga u upravljanju savremenim logističkim sistemima. Pregledno je prikazano kako pojedini autori definišu pojam i funkcije logističkog kontrolinga u savremenim logističkim sistemima. / In this paper a definition of logistic controlling in logistic systems has been given. The basic functions of logistic controlling are shown as well as its place and role in managing modern logistic systems. It is clearly shown how some other authors define the notion and the functions of logistic controlling in modern logistic systems.

  4. Implementation of Genetic Algorithm for Solving De Jong Test Function on Cloud Environment and Compare Its Performance with Local Host Environment

    Directory of Open Access Journals (Sweden)

    Syed Tauhid Zuhori

    2012-02-01

    Full Text Available In this day, Cloud Computing has gained large attention not only from IT specialists but also from many clients. It is global network (internet-based computing, where shared resources, software and information are provided to computers and other devices on-demand, like the electricity bill. Firstly Cost can be reduced and the technology is also known as green saver or power technology. Secondly, the dynamic and flexible scalability of cloud computing. The third is that cloud computing is platform independent means any internet supported system can be used to access cloud environment. In our paper, we will discuss the utility of the cloud computing for scientific computing. Google App Engine (GAE is adopted because it is open source or free and good software development Kit is available. Simple Genetic Algorithm are implemented on the GAE for solving the minimization of De Jong Test Function and for measuring the performance of cloud for showing that how cloud is the better choice than desktop

  5. Question Utilization in Solution-Focused Brief Therapy: A Recursive Frame Analysis of Insoo Kim Berg's Solution Talk

    Science.gov (United States)

    Cotton, Jeffrey

    2010-01-01

    Recursive frame analysis (RFA) was used to conduct a single case investigation of Insoo Kim Berg's question utilization talk in a solution-focused brief therapy (SFBT) session. Due to the lack of process research that explores how SFBT questions facilitate change, the author investigated how Berg's solution language influenced a client to respond…

  6. Language and Family Dispersion: North Korean Linguist Kim Su-gyŏng and the Korean War

    Directory of Open Access Journals (Sweden)

    Ryuta Itagaki

    2017-03-01

    Full Text Available This article analyzes the unpublished memoir of Kim Su-gyŏng (1918–2000, a linguist who was active in North Korea from the mid-1940s until the late 1960s, and situates his account of his experience of the Korean War within the context of his linguistic essays and correspondence. In doing so, the article considers the role that the personal and the social play in language, utilizing Saussure’s theoretical framework, with which Kim himself was well versed. Kim wrote his memoirs in the 1990s to his family, from whom he had become separated during the Korean War and who now lived in Toronto. In this text, he writes in “personal” language that reveals his uncertainty and his feelings for his family, but then immediately negates these feelings through the use of “social” language, which resonates with his interpretation of the linguistic thesis that Josef Stalin developed during the Korean War on language and national identity. For Kim, the relationship between language and nation was not at all self-evident, but something that he idealized in response to the dispersal of his family. By offering a reflexive reading of a memoir written by a North Korean linguist, this article makes a breakthrough in the investigation of North Korean wartime academic history, which has not risen above the level of analyzing articles in the field of linguistics that were published at the time.

  7. General characteristics of causes of urban flood damage and flood forecasting/warning system in Seoul, Korea Young-Il Moon1, 2, Jong-Suk Kim1, 2 1 Department of Civil Engineering, University of Seoul, Seoul 130-743, South Korea 2 Urban Flood Research Inst

    Science.gov (United States)

    Moon, Young-Il; Kim, Jong-Suk

    2015-04-01

    Due to rapid urbanization and climate change, the frequency of concentrated heavy rainfall has increased, causing urban floods that result in casualties and property damage. As a consequence of natural disasters that occur annually, the cost of damage in Korea is estimated to be over two billion US dollars per year. As interest in natural disasters increase, demands for a safe national territory and efficient emergency plans are on the rise. In addition to this, as a part of the measures to cope with the increase of inland flood damage, it is necessary to build a systematic city flood prevention system that uses technology to quantify flood risk as well as flood forecast based on both rivers and inland water bodies. Despite the investment and efforts to prevent landside flood damage, research and studies of landside-river combined hydro-system is at its initial stage in Korea. Therefore, the purpose of this research introduces the causes of flood damage in Seoul and shows a flood forecasting and warning system in urban streams of Seoul. This urban flood forecasting and warning system conducts prediction on flash rain or short-term rainfall by using radar and satellite information and performs prompt and accurate prediction on the inland flooded area and also supports synthetic decision-making for prevention through real-time monitoring. Although we cannot prevent damage from typhoons or localized heavy rain, we can minimize that damage with accurate and timely forecast and a prevention system. To this end, we developed a flood forecasting and warning system, so in case of an emergency there is enough time for evacuation and disaster control. Keywords: urban flooding, flood risk, inland-river system, Korea Acknowledgments This research was supported by a grant (13AWMP-B066744-01) from Advanced Water Management Research Program (AWMP) funded by Ministry of Land, Infrastructure and Transport of Korean government.

  8. SCREENING OF PRESCHOOL CHILDREN FOR BLOOD LEAD LEVELS AT KIMS HOSPITAL

    Directory of Open Access Journals (Sweden)

    Chandrakala

    2014-03-01

    Full Text Available OBJECTIVE: to screen preschool children for blood lead level with an objective to estimate ZPP levels among preschool children attending OPD and admitted to wards and to confirm blood lead levels in children whose ZPP is>_35ugm/dl. METHODS: hospital based descriptive study conducted at KIMS, BANGALORE from 1st July 2007 to 31st July 2008. 100 preschool children aged between 1 to 6 years who came to OPD and were admitted, were chosen randomly. Data was collected in a simple questionnaire which included demographic, clinical, investigations. Venous blood, 2 ml was drawn and estimated for ZPP. If ZPP >_ 35ugm/dl, then blood samples were estimated for blood lead levels. The data collected in this study was analyzed statistically using chi square test and standard normal variate (Z test for proportions. RESULTS: Out of 100 children, 37% of them had ZPP > 35 ugm/dl .Among these 20% had blood level more >10ugm/dl. Socio economic status affects lead exposure with poor socio economic status group being most prone for lead absorption. Among the 20% who had blood lead levels >10 ugm/dl, 15% of them belonged to urban area and 5% belonged to rural area. Location of the house of children in this study was observed that in industrial area were 85%, mechanic factory were 7%, battery factory were 3%, automobile and cottage industry were 2% . Among 100 children, 57 had hemoglobin % of > 10 gm and 43 were anemic having hemoglobin <10 gm%. CONCLUSION: As lead poisoning patients can be asymptomatic or symptomatic with only vague presentations, screening of blood lead levels should be made as a routine investigation. Awareness should be created regarding the sources of lead, its exposure and potential health effects

  9. Surgical technique for single-port laparoscopy in huge ovarian tumors: SW Kim's technique and comparison to laparotomy.

    Science.gov (United States)

    Kim, Jeong Sook; Lee, In Ok; Eoh, Kyung Jin; Chung, Young Shin; Lee, Inha; Lee, Jung-Yun; Nam, Eun Ji; Kim, Sunghoon; Kim, Young Tae; Kim, Sang Wun

    2017-03-01

    This study aimed to introduce a method to remove huge ovarian tumors (≥15 cm) intact with single-port laparoscopic surgery (SPLS) using SW Kim's technique and to compare the surgical outcomes with those of laparotomy. Medical records were retrospectively reviewed for patients who underwent either SPLS (n=21) with SW Kim's technique using a specially designed 30×30-cm(2)-sized 3XL LapBag or laparotomy (n=22) for a huge ovarian tumor from December 2008 to May 2016. Perioperative surgical outcomes were compared. In 19/21 (90.5%) patients, SPLS was successfully performed without any tumor spillage or conversion to multi-port laparoscopy or laparotomy. There was no significant difference in patient characteristics, including tumor diameter and total operation time, between both groups. The postoperative hospital stay was significantly shorter for the SPLS group than for the laparotomy group (median, 2 [1 to 5] vs. 4 [3 to 17] days; Phuge ovarian tumors.

  10. A KIM-compliant potfit for fitting sloppy interatomic potentials: Application to the EDIP model for silicon

    CERN Document Server

    Wen, Mingjian; Brommer, Peter; Elliott, Ryan S; Sethna, James P; Tadmor, Ellad B

    2016-01-01

    Fitted interatomic potentials are widely used in atomistic simulations thanks to their ability to compute the energy and forces on atoms quickly. However, the simulation results crucially depend on the quality of the potential being used. Force matching is a method aimed at constructing reliable and transferable interatomic potentials by matching the forces computed by the potential as closely as possible, with those obtained from first principles calculations. The potfit program is an implementation of the force-matching method that optimizes the potential parameters using a global minimization algorithm followed by a local minimization polish. We extended potfit in two ways. First, we adapted the code to be compliant with the KIM Application Programming Interface (API) standard (part of the Knowledgebase of Interatomic Models Project). This makes it possible to use potfit to fit many KIM potential models, not just those prebuilt into the potfit code. Second, we incorporated the geodesic Levenberg--Marquardt...

  11. A KIM-compliant potfit for fitting sloppy interatomic potentials: application to the EDIP model for silicon

    Science.gov (United States)

    Wen, Mingjian; Li, Junhao; Brommer, Peter; Elliott, Ryan S.; Sethna, James P.; Tadmor, Ellad B.

    2017-01-01

    Fitted interatomic potentials are widely used in atomistic simulations thanks to their ability to compute the energy and forces on atoms quickly. However, the simulation results crucially depend on the quality of the potential being used. Force matching is a method aimed at constructing reliable and transferable interatomic potentials by matching the forces computed by the potential as closely as possible, with those obtained from first principles calculations. The potfit program is an implementation of the force-matching method that optimizes the potential parameters using a global minimization algorithm followed by a local minimization polish. We extended potfit in two ways. First, we adapted the code to be compliant with the KIM Application Programming Interface (API) standard (part of the Knowledgebase of Interatomic Models project). This makes it possible to use potfit to fit many KIM potential models, not just those prebuilt into the potfit code. Second, we incorporated the geodesic Levenberg-Marquardt (LM) minimization algorithm into potfit as a new local minimization algorithm. The extended potfit was tested by generating a training set using the KIM environment-dependent interatomic potential (EDIP) model for silicon and using potfit to recover the potential parameters from different initial guesses. The results show that EDIP is a ‘sloppy model’ in the sense that its predictions are insensitive to some of its parameters, which makes fitting more difficult. We find that the geodesic LM algorithm is particularly efficient for this case. The extended potfit code is the first step in developing a KIM-based fitting framework for interatomic potentials for bulk and two-dimensional materials. The code is available for download via https://www.potfit.net.

  12. Evaluation of medium-range weather forecasts about Korea Institute of Atmospheric Prediction Systems (KIAPS) Integrated Model System (KIM)

    Science.gov (United States)

    Lee, J.; Seol, K. H.

    2015-12-01

    The Korea Institute of Atmospheric Prediction Systems (KIAPS) is a government funded non-profit research and development institute located in Seoul, South Korea. KIAPS was established in 2011 by the Korea Meteorological Administration, KIAPS' primary sponsor. KIAPS is developing the KIAPS Integrated Model System (KIM), a backbone for the next-generation operational global numerical weather prediction (NWP) system. The KIM will be a unified model that can be used for global modeling as well as local areas, particularly optimized to topographic and meteorological features of the Korean Peninsula. We have been completed developing major model components based on KIAPS own research and release the KIAPS beta version model on September 2014. We evaluated the results of KIM by using verification system developed KIAPS, it is composed of standard verification score based on WMO report. The system consists of four parts: verification against analysis, observations, vertical verification and quantitative precipitation forecasts. The results of verification against analysis, we found that increase of error for temperature under 700 hPa. In case of MSLP, poor performance except for tropical region is represented, and the increase of error for geopotential height is shown in tropical region. For verification against observations, positive bias is represented for upper level geopotential height, for low level wind speed in tropical region in summer, for all level wind speed in Northern Hemisphere in winter, and for specific humidity in Northern Hemisphere in summer. As previously stated about the result against analysis, cold bias for low level temperature is shown in Northern Hemisphere in summer. In case of verification for rain about KIM, the model value is underestimated in heavy rain category in summer, on the contrary, that is overestimated in heavy rain category in winter. Overall, there is overestimation in ocean for all models. Our findings indicate that continuing

  13. A new record of Cleantioides emarginata Kwon & Kim,1992 (Crustacea, Isopoda, Valvifera) from Changjiang River estuary, China

    Institute of Scientific and Technical Information of China (English)

    LIU Wenliang; Gary C.B.POORE

    2013-01-01

    At present,descriptions of Cleantioides emarginata Kwon & Kim,1992 have been limited to the type locality of Pusan,Korea.In this study,we discovered this species in the Changjiang (Yangtze) River estuary,China.This represents an extension of the known geographical range of C.emarginata.In addition,we present information of a colour pattern not previously described,along with details on the estuarine habitat of the species.

  14. Lactobacillus curvatus WiKim38 isolated from kimchi induces IL-10 production in dendritic cells and alleviates DSS-induced colitis in mice.

    Science.gov (United States)

    Jo, Sung-Gang; Noh, Eui-Jeong; Lee, Jun-Young; Kim, Green; Choi, Joo-Hee; Lee, Mo-Eun; Song, Jung-Hee; Chang, Ji-Yoon; Park, Jong-Hwan

    2016-07-01

    Probiotics such as lactobacilli and bifidobacteria have healthpromoting effects by immune modulation. In the present study, we examined the immunomodulatory properties of Lactobacillus curvatus WiKim38, which was newly isolated from baechu (Chinese cabbage) kimchi. The ability of L. curvatus WiKim38 to induce cytokine production in bone marrow-derived dendritic cells (BMDCs) was determined by enzyme-linked immunosorbent assay. To evaluate the molecular mechanisms underlying L. curvatus Wikim38-mediated IL-10 production, Western blot analyses and inhibitor assays were performed. Moreover, the in vivo anti-inflammatory effects of L. curvatus WiKim38 were examined in a dextran sodium sulfate (DSS)-induced colitis mouse model. L. curvatus WiKim38 induced significantly higher levels of IL-10 in BMDCs compared with that induced by LPS. NF-κB and ERK were activated by L. curvatus WiKim38, and an inhibitor assay revealed that these pathways were required for L. curvatus WiKim38-induced production of IL-10 in BMDCs. An in vivo experiment showed that oral administration of L. curvatus WiKim38 increased the survival rate of mice with DSS-induced colitis and improved clinical signs and histopathological severity in colon tissues. Taken together, these results indicate that L. curvatus Wikim38 may have health-promoting effects via immune modulation, and may thus be applicable for therapy of various inflammatory diseases.

  15. Drug screening in urine by cloned enzyme donor immunoassay (CEDIA) and kinetic interaction of microparticles in solution (KIMS): a comparative study.

    Science.gov (United States)

    Schwettmann, Lutz; Külpmann, Wolf-Rüdiger; Vidal, Christian

    2006-01-01

    Two commercially available drug-screening assays were evaluated: the Roche kinetic interaction of microparticles in solution (KIMS) assay and the Microgenics cloned enzyme donor immunoassay (CEDIA). Urine samples from known drug-abuse patients were analyzed for amphetamines, barbiturates, benzodiazepines, benzoylecgonine, cannabinoids, LSD, methadone and opiates. Samples with discordant findings for the two assays were analyzed by gas chromatography/mass spectrometry (GC/MS) or gas chromatography/electron capture detection (GC/ECD). Amphetamines showed 96.0% concordant results, with two false positive findings by CEDIA, three by KIMS and a further two false negatives by KIMS. Barbiturates showed 99.4% concordant results, with one false negative by KIMS. Benzodiazepines showed 97.4% concordant results, with two false negatives by KIMS (cutoff 100 microg/L, CEDIA cutoff 300 microg/L). Benzoylecgonine showed 17.8% concordant positive and 82.2% concordant negative results and no false finding by either assay. Cannabinoids showed 99.3% concordant results, with one sample negative by KIMS at a cutoff of 50 microg/L and positive by CEDIA (cutoff 25 microg/L). For LSD, 6.7% of findings were not in agreement. Methadone showed 97.5% concordant results, with two false positives by CEDIA, and one false positive and one false negative by KIMS. Opiates showed 96.9% concordant results, with no false KIMS results, but four false positives by CEDIA. The results indicate that the agreement of the CEDIA and KIMS results for the eight drugs is rather good (93.3-100%).

  16. 06 Henk de Jong Finalx

    African Journals Online (AJOL)

    abel

    considered relevant for future warfare in Europe. They almost completely .... inequality, exploitation and disregard for self-determination and national rights, and even military ...... Writing a wider war: Rethinking gender, race and identity in the ...

  17. Muusikauudised : Lu : k ja Jäääär koos laval. Britney Spears tegutseb. Lenny Kravitz ja Mick Jagger. Kim Wilde

    Index Scriptorium Estoniae

    2001-01-01

    Tartus Sõbra majas toimunud kontserdist. Videost "Britney: The video". Heliplaatidest: "Britney", "The Best of Pink Floyd", "Lenny", Mick Jagger "Goddess In The Doorway", "The Very Best Of Kim Wilde"

  18. Muusikauudised : Lu : k ja Jäääär koos laval. Britney Spears tegutseb. Lenny Kravitz ja Mick Jagger. Kim Wilde

    Index Scriptorium Estoniae

    2001-01-01

    Tartus Sõbra majas toimunud kontserdist. Videost "Britney: The video". Heliplaatidest: "Britney", "The Best of Pink Floyd", "Lenny", Mick Jagger "Goddess In The Doorway", "The Very Best Of Kim Wilde"

  19. The Key Indicator Method for Manual Handling Operations (KIM-MHO - evaluation of a new method for the assessment of working conditions within a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Gebhardt Hansjürgen

    2010-11-01

    Full Text Available Abstract Background Upper extremity musculoskeletal symptoms and disorders are common in the working population. The economic and social impact of such disorders is considerable. Long-time, dynamic repetitive exposure of the hand-arm system during manual handling operations (MHO alone or in combination with static and postural effort are recognised as causes of musculoskeletal symptoms and disorders. The assessment of these manual work tasks is crucial to estimate health risks of exposed employees. For these work tasks, a new method for the assessment of the working conditions was developed by the Federal Institute for Occupational Safety and Health (BAuA and released as a draft in the year 2007. The draft of the so-called Key Indicator Method for Manual Handling Operations (KIM-MHO was developed in analogy with the existing KIM for Lifting/Holding/Carrying (KIM-LHC and Pulling/Pushing (KIM-PP of loads. The KIM-MHO is designed to fill the gap existing in risk assessment of manual work processes, since the existing KIMs deal only with manual handling of loads. This research project focused on the following: - Examination of the validity of workplace assessment with the KIM-MHO comparing expert ratings with the results of the observations. - Examination of the objectivity of workplace assessment with the KIM-MHO applied by different examiners. - Examination of the criterion validity of the risk assessment provided by KIM-MHO with respect to the association between exposure and the occurrence and prevalence of health related outcomes. Methods/Design To determine the objectivity and validity of workplace assessment, the KIM-MHO is applied by occupational health and safety officers at different workplaces involving manual handling operations. To determine the criterion validity of risk assessment, a survey of employees at different workplaces takes place with standardised questionnaires and interviews about symptoms in the neck and upper extremities

  20. A STUDY ON BACTERIAL CONTAMINATION OF CELL PHONES OF HEALTH CARE WORKERS (HCW AT KIMS HOSPITAL, AMALAPURAM

    Directory of Open Access Journals (Sweden)

    Padmaja

    2014-04-01

    Full Text Available A random 100 samples of cell phones of HCWs workers and Doctors working in various wards, OPDs and laboratories, Blood Bank, Causality, ICU of KIMS Hospital were subjected to bacterial analysis by conventional methods to know about the Bacterial contamination of the cell phones from July 2011 to December 2011. The commonest organism isolated from the contaminated cell phone is MRSA - 20%, followed by MSSA - 5%, CONS - 10 %, Micrococcus - 15 %. The obvious observation is none of the doctors’ cell phones are contaminated. In the present study, the contamination rate is compared to the controlled group consisting patients, relatives attending in OPD’s and not working in health care setting.

  1. New Nordic Exceptionalism: Jeuno JE Kim and Ewa Einhorn's The United Nations of Norden and other realist utopias

    Directory of Open Access Journals (Sweden)

    Mathias Danbolt

    2016-11-01

    Full Text Available At the 2009 Nordic Culture Forum summit in Berlin that centered on the profiling and branding of the Nordic region in a globalized world, one presenter stood out from the crowd. The lobbyist Annika Sigurdardottir delivered a speech that called for the establishment of “The United Nations of Norden”: A Nordic union that would gather the nations and restore Norden's role as the “moral superpower of the world.” Sigurdardottir's presentation generated such a heated debate that the organizers had to intervene and reveal that the speech was a performance made by the artists Jeuno JE Kim and Ewa Einhorn. This article takes Kim and Einhorn's intervention as a starting point for a critical discussion of the history and politics of Nordic image-building. The article suggests that the reason Kim and Einhorn's speech passed as a serious proposal was due to its meticulous mimicking of two discursive formations that have been central to the debates on the branding of Nordicity over the last decades: on the one hand, the discourse of “Nordic exceptionalism,” that since the 1960s has been central to the promotion of a Nordic political, socio-economic, and internationalist “third way” model, and, on the other hand, the discourse on the “New Nordic,” that emerged out of the New Nordic Food-movement in the early 2000s, and which has given art and culture a privileged role in the international re-fashioning of the Nordic brand. Through an analysis of Kim and Einhorn's United Nations of Norden (UNN-performance, the article examines the historical development and ideological underpinnings of the image of Nordic unity at play in the discourses of Nordic exceptionalism and the New Nordic. By focusing on how the UNN-project puts pressure on the role of utopian imaginaries in the construction of Nordic self-images, the article describes the emergence of a discursive framework of New Nordic Exceptionalism.

  2. Report on visit from Prof. Kim Lutzen: Friday, 6 November 1998, Korolinska Institute (dept of nursing Stockholm, Sweden

    Directory of Open Access Journals (Sweden)

    Kim Lutzen

    1999-01-01

    Full Text Available Prof. Kim Lutzen contacted the Department of Advanced Nursing Sciences, Unisa, via the Department's Web Page. Prof. Lutzen is the Chair of the Department of Nursing, which offers undergraduate, master and doctoral programmes. This Department of Nursing is situated within the Karolinska Institute, which comprises 29 Departments of Health Sciences, including a number of Medical Departments, Dentistry, Occupational Therapy, Physiotherapy, and Nursing. Prof. Lutzen emphasised that there is no Swedish phrase similar to "nursing science", consequently this t e n seems to be somewhat unfamiliar to the Swedish nurses. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

  3. Analiza parametra translucencije staklokeramike izrađene različitim tehnološkim postupcima

    OpenAIRE

    Ledić, Karla; Majnarić, Igor; MILARDOVIĆ ORTOLAN, Slađana; Špalj, Stjepan; Štefančić, Sanja; Mehulić, Ketij

    2015-01-01

    Svrha: Analizirati parametar translucencije (TP vrijednosti) staklokeramika izrađenih različitim tehnološkim postupcima te ispitati kako na TP vrijednosti utječu korozivna sredstva. Materijali i metode: Izrađena su po tri uzorka IPS e.max keramike (Ivoclar Vivadent, Schaan, Lihtenštajn) u trima bojama (A2, C2 i B3) s trima različitim tehnologijama izrade (slojevanje – e.max Ceram Dentin; toplo-tlačna tehnika – e.max Press; strojno – e.max CAD). Uzorci su bili u obliku pločica dimenzija 10 mm ...

  4. A Density Functional Approach to Polarizable Models: A Kim-Gordon-Response Density Interaction Potential for Molecular Simulations

    Energy Technology Data Exchange (ETDEWEB)

    Tabacchi, G; Hutter, J; Mundy, C

    2005-04-07

    A combined linear response--frozen electron density model has been implemented in a molecular dynamics scheme derived from an extended Lagrangian formalism. This approach is based on a partition of the electronic charge distribution into a frozen region described by Kim-Gordon theory, and a response contribution determined by the instaneous ionic configuration of the system. The method is free from empirical pair-potentials and the parameterization protocol involves only calculations on properly chosen subsystems. They apply this method to a series of alkali halides in different physical phases and are able to reproduce experimental structural and thermodynamic properties with an accuracy comparable to Kohn-Sham density functional calculations.

  5. Helen Kim as New Woman and Collaborator: A Comprehensive Assessment of Korean Collaboration under Japanese Colonial Rule

    Directory of Open Access Journals (Sweden)

    AhRan Ellie Bae

    2017-02-01

    Full Text Available Although almost seventy years has passed since Korea's liberation from Japanese rule, the issue of collaboration still haunts Korea today. Attempts to resolve this issue have tended to focus attention on the traitorous actions of "collaborators" without considering the gray areas that surround their actions such as the circumstances that influenced the accused to commit their alleged traitorous acts and the intentions that drove their decisions. Helen Kim, as a "new woman" and an educator, valued the necessity of providing education for women. Yet, her efforts to realize this goal, to the contrary, forced her into actions that would later be used to construct a reputation as a Japanese collaborator. Korea's nationalist historiography has a tendency to polarize this issue by categorizing a "collaborator" as either a traitor or a patriot. However, when we take a closer look at these collaborators' lives, we discover that most collaboration happened in gray areas where it is often difficult to clearly draw a line between treason and collaboration. Helen Kim's case suggests that the issue of collaboration cannot be fully explained by nationalist historiography's framework and we must give attention to these gray areas. Through her story I hope to complicate the issue of collaboration by raising questions that address the gray areas that surround the actions of "collaborators." In doing so, I hope to challenge the nationalist historiography's propensity to oversimplify this issue and present a more nuanced understanding of it.

  6. Recovery from a Financial Meltdown: The Political Economy of Crisis Management under the Kim Dae-Jung Administration

    Directory of Open Access Journals (Sweden)

    Shalendra D. Sharma

    2002-12-01

    Full Text Available In Korea, the IMF-supported program, approved in late 1997, focused on financial sector restructuring, corporate governance, capital account liberalization, labor market reforms and trade liberalization. As in Thailand, it soon became clear that the IMF program underestimated the severity and deIn Korea, the IMF-supported program, approved in late 1997, focused on financial sector restructuring, corporate governance, capital account liberalization, labor market reforms and trade liberalization. As in Thailand, it soon became clear that the IMF program underestimated the severity and depth of the crisis. It fell upon the newly-elected government of Kim Dae-Jung to deal with both the crisis and the IMF. This paper illustrates how the Kim Dae-Jung administration deftly dealt with the grave challenges it faced. Korea's remarkable economic recovery, is in large measure, due to the government's prudent handling of the numerous economic challenges it faced. This paper examines the Korean government's management of the crisis-documenting both its achievements and the challenges ahead.

  7. Pyongyangi leedi Macbeth tõmbab niite Põhja-Koreas / Yuriko Koike

    Index Scriptorium Estoniae

    Koike, Yuriko

    2010-01-01

    Põhja-Korea liidri Kim Jong-il'i õest Kim Kyong-hui'st. Autori, Jaapani endise kaitseministri väitel on hakatud uskuma, et Kim Jong-il võib igal hetkel määrata just Kim Kyong-hui üleminekuaja valitsejaks, kes peab korraldama tema surma järel kolmanda põlvkonna Kimi võimuletuleku, kuid Kim Kyong-hui võib ise ihata saada Kim Jong-ili mantlipärijaks

  8. Pyongyangi leedi Macbeth tõmbab niite Põhja-Koreas / Yuriko Koike

    Index Scriptorium Estoniae

    Koike, Yuriko

    2010-01-01

    Põhja-Korea liidri Kim Jong-il'i õest Kim Kyong-hui'st. Autori, Jaapani endise kaitseministri väitel on hakatud uskuma, et Kim Jong-il võib igal hetkel määrata just Kim Kyong-hui üleminekuaja valitsejaks, kes peab korraldama tema surma järel kolmanda põlvkonna Kimi võimuletuleku, kuid Kim Kyong-hui võib ise ihata saada Kim Jong-ili mantlipärijaks

  9. Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography.

    Science.gov (United States)

    Torregrosa, Isidro; Montoliu, Carmina; Urios, Amparo; Andrés-Costa, María Jesús; Giménez-Garzó, Carla; Juan, Isabel; Puchades, María Jesús; Blasco, María Luisa; Carratalá, Arturo; Sanjuán, Rafael; Miguel, Alfonso

    2015-11-01

    Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type fatty acid-binding protein (uL-FABP) for early detection of AKI in these patients, comparing their performance with another group of cardiac surgery patients. Biomarkers were measured in 193 patients, 12 h after intervention. In the ROC analysis, AUC for KIM-1, NGAL and L-FABP was 0.713, 0.958 and 0.642, respectively, in the coronary angiography group, and 0.716, 0.916 and 0.743 in the cardiac surgery group. Urinary KIM-1 12 h after intervention is predictive of AKI in adult patients undergoing coronary angiography, but NGAL shows higher sensitivity and specificity. L-FABP provides inferior discrimination for AKI than KIM-1 or NGAL in contrast to its performance after cardiac surgery. This is the first study showing the predictive capacity of KIM-1 for AKI after coronary angiography. Further studies are still needed to answer relevant questions about the clinical utility of biomarkers for AKI in different clinical settings.

  10. New Nordic Exceptionalism: Jeuno JE Kim and Ewa Einhorn’s 'The United Nations of Norden' and Other Realist Utopias

    DEFF Research Database (Denmark)

    Danbolt, Mathias

    2016-01-01

    that have been central to the debates on the branding of Nordicity over the last decades: on the one hand, the discourse of “Nordic exceptionalism,” that since the 1960s has been central to the promotion of a Nordic political, socio-economic, and internationalist “third way” model, and, on the other hand......, the discourse on the “New Nordic,” that emerged out of the New Nordic Food-movement in the early 2000s, and which has given art and culture a privileged role in the international re-fashioning of the Nordic brand. Through an analysis of Kim and Einhorn’s United Nations of Norden (UNN)-performance, the article...

  11. Understanding internal backgrounds in NaI(Tl) crystals toward a 200 kg array for the KIMS-NaI experiment

    Energy Technology Data Exchange (ETDEWEB)

    Adhikari, P.; Adhikari, G.; Oh, S.Y. [Sejong University, Department of Physics, Seoul (Korea, Republic of); Choi, S.; Joo, H.W.; Kim, K.W.; Kim, S.K. [Seoul National University, Department of Physics and Astronomy, Seoul (Korea, Republic of); Ha, C.; Jeon, E.J.; Kang, W.G.; Kim, H.O.; Kim, N.Y.; Lee, H.S.; Lee, J.H.; Lee, M.H.; Leonard, D.S.; Li, J.; Olsen, S.L.; Park, H.K.; Park, K.S.; So, J.H.; Yoon, Y.S. [Institute for Basic Science, Center for Underground Physics, Daejeon (Korea, Republic of); Hahn, I.S. [Ewha Womans University, Department of Science Education, Seoul (Korea, Republic of); Kim, H.J. [Kyungpook National University, Department of Physics, Daegu (Korea, Republic of); Kim, Y.D. [Sejong University, Department of Physics, Seoul (Korea, Republic of); Institute for Basic Science, Center for Underground Physics, Daejeon (Korea, Republic of); Kim, Y.H. [Institute for Basic Science, Center for Underground Physics, Daejeon (Korea, Republic of); Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of); Park, H.S. [Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of)

    2016-04-15

    The Korea Invisible Mass Search (KIMS) collaboration has developed low-background NaI(Tl) crystals that are suitable for the direct detection of WIMP dark matter. Building on experience accumulated during the KIMS-CsI programs, the KIMS-NaI experiment will consist of a 200 kg NaI(Tl) crystal array surrounded by layers of shielding structures and will be operated at the Yangyang underground laboratory. The goal is to provide an unambiguous test of the DAMA/LIBRA annual modulation signature. Measurements of six prototype crystals show progress in the reduction of internal contamination from radioisotopes. Based on our understanding of these measurements, we expect to achieve a background level in the final detector configuration that is less than 1 count/day/keV/kg for recoil energies around 2 keV. The annual modulation sensitivity for the KIMS-NaI experiment shows that an unambiguous 7σ test of the DAMA/LIBRA signature would be possible with a 600 kg year exposure with this system. (orig.)

  12. Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM1) in patients with diabetic nephropathy: a cross-sectional study and the effects of lisinopril

    DEFF Research Database (Denmark)

    Nielsen, S E; Schjoedt, K J; Astrup, A S

    2010-01-01

    Our aim was to evaluate the markers of tubulointerstitial damage, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule1 (KIM1) in Type 1 diabetic patients with different levels of albuminuria and in control subjects. In addition, the effect of renoprotective treatment...... on urinary NGAL was evaluated in diabetic nephropathy....

  13. Social Status Construction of the Kim Families ’ in Xiuning County%休宁金氏宗族社会地位构建

    Institute of Scientific and Technical Information of China (English)

    朱玉荣

    2014-01-01

    徽州是典型的宗族社会,等级门第观念较严格,社会地位高低是宗族能否立足的重要凭证,因此,提高宗族的社会地位是宗族赋予族众的使命。休宁金氏宗族传承千年,世代以忠孝显名。通过对《休宁金氏族谱》进行研究可知,金氏宗族构建社会地位的方式主要有进行宗族管理、获得社会认同和官府认同等三方面。%Huizhou was a typical clan society .obsession of hierarchy here was stricter .So ,it was important to improve the clan’s social status ,which was the families’ mission .The Kim families in Xiuning County had been inherited for more than one thousand years .They were famous for their loyalty and filial piety .To build social status ,the Kim families made unre-mitting efforts .According to The Kim Families’ documents ,we can know that the Kim families built their social status by clan managing ,obtaining social identity and official recognition .

  14. Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time

    NARCIS (Netherlands)

    Kramer, Andrea B.; van Timmeren, Mirjan M.; Schuurs, Theo A.; Vaidya, Vishal S.; Bonventre, Joseph V.; van Goor, Harry; Navis, Gerjan

    2009-01-01

    Kramer AB, van Timmeren MM, Schuurs TA, Vaidya VS, Bonventre JV, van Goor H, Navis G. Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time. Am J Physiol Renal Physiol 296: F1136-F1145, 2009. First published February

  15. Understanding internal backgrounds of NaI(Tl) crystals toward a 200~kg array for the KIMS-NaI experiment

    CERN Document Server

    Adhikari, P; Choi, S; Ha, C; Hahn, I S; Jeon, E J; Joo, H W; Kang, W G; Kim, H J; Kim, H O; Kim, K W; Kim, N Y; Kim, S K; Kim, Y D; Kim, Y H; Lee, H S; Lee, J H; Lee, M H; Leonard, D S; Li, J; Oh, S Y; Olsen, S L; Park, H K; Park, H S; Park, K S; So, J H; Yoon, Y S

    2015-01-01

    The Korea Invisible Mass Search (KIMS) collaboration has developed low-background NaI(Tl) crystals that are suitable for the direct detection of WIMP dark matter. With experience built on the KIMS-CsI programs, the KIMS-NaI experiment will consist of a 200~kg NaI(Tl) crystal array surrounded by layers of shielding structures and will be operated at the Yangyang underground laboratory. The goal is to provide an unambiguous test of the DAMA/LIBRA's annual modulation signature. Measurements of six prototype crystals show progress in the reduction of internal contaminations of radioisotopes. Based on our understanding of these measurements, we expect to achieve a background level in the final detector configuration that is less than 1~count/day/keV/kg for recoil energies around 2~keV. The annual modulation sensitivity for the KIMS-NaI experiment shows that an unambiguous 7$\\sigma$ test of the DAMA/LIBRA signature would be possible with a 600~kg$\\cdot$year exposure with this system.

  16. VALIDATION OF COOKING TIMES AND TEMPERATURES FOR THERMAL INACTIVATION OF YERSINIA PESTIS STRAINS KIM5 AND CDC-A1112 IN GROUND BEEF

    Science.gov (United States)

    The thermal stability of Yersinia pestis inoculated into retail ground beef (25 per cent fat) and heated in a temperature-controlled water bath or cooked on commercial grills was evaluated. Irradiated ground beef (3-g portions) was inoculated with ca. 6.7 log10 CFU/g of Y. pestis strain KIM5 and hea...

  17. VizieR Online Data Catalog: Spitzer/IRS survey of Class II objects in Orion A. I. (Kim+, 2016)

    Science.gov (United States)

    Kim, K. H.; Watson, D. M.; Manoj, P.; Forrest, W. J.; Furlan, E.; Najita, J.; Sargent, B.; Hernandez, J.; Calvet, N.; Adame, L.; Espaillat, C.; Megeath, S. T.; Muzerolle, J.; McClure, M. K.

    2016-10-01

    We present 319 Class II disks observed with Spitzer/IRS in the Orion A star-forming region. We described the Spitzer/IRS and IRTF/SpeX observations and data reduction process in Kim+ (2013, J/ApJ/769/149). The Orion A objects in this paper were selected based on the identification of young stars with disks by IRAC/Two Micron All Sky Survey (2MASS) color-color diagrams (Megeath+ 2012, J/AJ/144/192). We observed them using Spitzer/IRS during campaigns 36, 39, 40, and 44 between 2006 November and 2007 October. To this group we added 16 additional objects (5 in the ONC; 11 in L1641) that were reclassified as Class II from Class 0/I sources observed in the Orion A protostar survey by C. Poteet et al. (2016, in preparation); 14 of these 16 were observed during campaigns 39 and 40, but 2 sources were observed in campaign 56 (see table 1). Of our IRS targets observed in both SL and LL modules in Orion A with Spitzer/IRS, we observed 120 at near-IR (0.8-2.4um) wavelengths with the medium-resolution spectrograph SpeX, on the NASA IRTF on Mauna Kea during the 2010A, 2011A, and 2011B semesters (see table 3). (9 data files).

  18. The influence of bile salt on the chemotherapeutic response of docetaxel-loaded thermosensitive nanomicelles

    Directory of Open Access Journals (Sweden)

    Kim DW

    2014-08-01

    Full Text Available Dong Wuk Kim,1,* Thiruganesh Ramasamy,2,* Ju Yeon Choi,2 Jeong Hwan Kim,2 Chul Soon Yong,2 Jong Oh Kim,2 Han-Gon Choi1 1College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, South Korea; 2College of Pharmacy, Yeungnam University, Gyongsan, South Korea *These two authors contributed equally to this work Abstract: The primary aim of this work was to investigate the potential of bile salt, sodium taurocholate (NaTC, in improving the bioavailability and anti-tumor efficacy of docetaxel (DCT upon rectal administration. Poloxamer-based nanomicelles with thermosensitive and mucoadhesive properties were prepared using the cold method. The optimized nanomicellar formulation was evaluated in terms of physicochemical and viscoelastic parameters. Nanomicelles containing bile salt maintained sufficient gelation strength (234×102 mPa·s and mucoadhesive force (17.3×102 dyne/cm2 to be retained in the upper part of the rectum. They significantly enhanced the DCT internalization across the rectal mucosa and showed a high plasma level during the first 4 hours of the study period, compared to nanomicelles with no bile salt. As a result, a slightly higher rectal bioavailability of ~33% was observed in nanomicelles containing bile salt, compared to ~28% from the latter system. The higher pharmacokinetic parameters for rectally administered DCT/P407/P188/Tween 80/NaTC (0.25%/11%/15%/10%/0.1% by weight, respectively resulted in significant anti-tumor efficacy. However, the tumor regression rate for the NaTC group was not statistically different from that for nanomicelles without NaTC. Therefore, overall results suggest that thermosensitive nanomicelles could be a potential dosage form for improvement of the bioavailability and chemotherapeutic profile of DCT. Keywords: anti-cancer efficiency, bioavailability, docetaxel, liquid suppository, rectal delivery, thermosensitive

  19. Kim Scott’s Fiction within Western Australian Life-Writing: Voicing the Violence of Removal and Displacement

    Directory of Open Access Journals (Sweden)

    Cornelis Martin Renes

    2013-01-01

    Full Text Available It is nowadays evident that the West’s civilising, eugenic zeal have had a devastating impact on all aspects of the Indigenous-Australian community tissue, not least the lasting trauma of the Stolen Generations. The latter was the result of the institutionalisation, adoption, fostering, virtual slavery and sexual abuse of thousands of mixed-descent children, who were separated at great physical and emotional distances from their Indigenous kin, often never to see them again. The object of State and Federal policies of removal and mainstream absorption and assimilation between 1930 and 1970, these lost children only saw their plight officially recognised in 1997, when the Bringing Them Home report was published by the Federal government. The victims of forced separation and migration, they have suffered serious trans-generational problems of adaptation and alienation in Australian society, which have been not only documented from the outside in the aforementioned report but also given shape from the inside of and to Indigenous-Australian literature over the last three decades. The following addresses four Indigenous Western-Australian writers within the context of the Stolen Generations, and deals particularly with the semi-biographical fiction by the Nyoongar author Kim Scott, which shows how a very liminal hybrid identity can be firmly written in place yet. Un-writing past policies of physical and ‘epistemic’ violence on the Indigenous Australian population, his fiction addresses a way of approaching Australianness from an Indigenous perspective as inclusive, embracing transculturality within the nation-space.

  20. Concept development of "compassion fatigue" in clinical nurses: Application of Schwartz-Barcott and Kim's hybrid model

    Directory of Open Access Journals (Sweden)

    Mahdieh Sabery

    2017-06-01

    Full Text Available Compassion fatigue is not a new concept in nursing; yet, it is not well known and there is no fixed clear definition of the term. The ambiguity surrounding how to define compassion fatigue has challenged its measurement and evaluation. Thus, any attempt to determine attributes of this underdeveloped concept and studying it in a new socio-cultural context requires concept development. The purpose of this study is to clarify the concept of compassion fatigue through concept development and to produce a vivid and tentative definition of this concept in clinical practice. Concept development was conducted using a three-step hybrid concept analysis including theoretical, fieldwork, and final analysis phases according to Schwartz-Barcott and Kim's method. We reviewed and analyzed 48 articles that met the inclusion criteria. Following, the first author conducted 13 interviews with clinical nurses followed by an inductive content analysis. Finally, a comprehensive definition of compassion fatigue in nurses was attained. Compassion fatigue in nurses can be explained as a cumulative and progressive process of absorption of the patient’s pain and suffering formed from the sympathetic and caring interactions with the patients and their families. The physical, emotional, intellectual, spiritual, social, and organizational consequences of compassion fatigue are so extensive that they threaten the existential integrity of the nurse. Context-based variables (culture, family, and community such as personality features like devotion behaviors and commitment towards the patient, exposure to multiple stressors, organizational challenges, and lack of self-care are factors associated with an increased risk of compassion fatigue. Concept development of compassion fatigue is the first step in the protection of nurses against the destructive consequences of compassion fatigue and to improve quality of care.

  1. Commentary on "Otolaryngology-head and neck surgery physician workforce issues an analysis for future specialty planning" by Kim, Cooper, and Kennedy.

    Science.gov (United States)

    Pryor, Shannon P; Brodsky, Linda; Chandrasekhar, Sujana S; Zaretsky, Lauren; Taylor, Duane J; Yaremchuk, Kathleen L; Pillsbury, Harold C

    2012-02-01

    An impending physician shortage has been projected. The article by Kim, Cooper, and Kennedy, titled "Otolaryngology-Head and Neck Surgery Physician Workforce Issues: An Analysis for Future Specialty Planning," is an attempt to evaluate and address this potential shortage as it applies to otolaryngology. The authors of this comment have concerns about the article's assumptions, design, and recommendations. Kim et al attempt to extrapolate data from other specialties and other countries to the US otolaryngology workforce, use that data in modeling methods without demonstrated validity, and based on their analysis, they recommend drastic changes to otolaryngologic training and practice in the United States. Particularly troublesome are (1) the emphasis placed on gender and part-time work and (2) the measurement of productivity defined as hours worked per week. Before redefining our specialty, more thorough and systematic data acquisition and review are necessary to meet the needs of our patients now and in the future.

  2. Seventy Years' Dance-Life of Kim Chun-heung(Abstract)%金千兴《心韶金千兴舞乐七十年》节选

    Institute of Scientific and Technical Information of China (English)

    金千兴; 奚治茹

    2011-01-01

    This paper,through retrospection of Kim Chun-heung's career as Korean traditional musical dance master,introduces the establishment of Korean National Music since the founding of South Korea,Kim Chun-heung Classical Dance Institute as well as Korean Masks%本文通过韩国著名传统乐舞大师金千兴先生艺术生涯的回顾,介绍了韩国建国后其大韩国乐的创建以及金千兴古典舞蹈研究所、韩国假面具保存会的开设,并通过金千兴先生恢复韩国传统宫中舞的经历介绍了韩国传统舞蹈及其保护的情况。

  3. Evaluation of objectivity, reliability and criterion validity of the key indicator method for manual handling operations (KIM-MHO), draft 2007.

    Science.gov (United States)

    Klußmann, André; Gebhardt, Hansjürgen; Rieger, Monika; Liebers, Falk; Steinberg, Ulf

    2012-01-01

    Upper extremity musculoskeletal symptoms and disorders are common in the working population. The economic and social impact of such disorders is considerable. Long-time, dynamic repetitive exposure of the hand-arm system during manual handling operations (MHO) alone or in combination with static and postural effort are recognised as causes of musculoskeletal symptoms and disorders. The assessment of these manual work tasks is crucial to estimate health risks of exposed employees. For these work tasks, a new method for the assessment of the working conditions was developed and a validation study was performed. The results suggest satisfying criterion validity and moderate objectivity of the KIM-MHO draft 2007. The method was modified and evaluated again. It is planned to release a new version of KIM-MHO in spring 2012.

  4. Urinary Biomarkers KIM-1 and NGAL for Detection of Chronic Kidney Disease of Uncertain Etiology (CKDu) among Agricultural Communities in Sri Lanka.

    Science.gov (United States)

    De Silva, Pallagae Mangala C S; Mohammed Abdul, Khaja Shameem; Eakanayake, Eakanayake M D V; Jayasinghe, Sudheera Sammanthi; Jayasumana, Channa; Asanthi, Hewa Bandulage; Perera, Hettiarachigae S D; Chaminda, Gamage G Tushara; Chandana, Ediriweera P S; Siribaddana, Sisira H

    2016-09-01

    Chronic Kidney Disease of uncertain etiology (CKDu) is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that CKDu is a tubulointerstitial disease. Urine albumin or albumin-creatinine ratio is still being used as a traditional diagnostic tool to identify CKDu, but accuracy and prevalence data generated are questionable. Urinary biomarkers have been used in similar nephropathy and are widely recognised for their sensitivity, specificity and accuracy in determining CKDu and early renal injury. However, these biomarkers have never been used in diagnosing CKDu in Sri Lanka. Male farmers (n = 1734) were recruited from 4 regions in Sri Lanka i.e. Matara and Nuwara Eliya (farming locations with no CKDu prevalence) and two CKDu emerging locations from Hambantota District in Southern Sri Lanka; Angunakolapelessa (EL1) and Bandagiriya (EL2). Albuminuria (ACR ≥ 30mg/g); serum creatinine based estimation of glomerular filtration rate (eGFR); creatinine normalized urinary kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were measured. Fourteen new CKDu cases (18%) from EL1 and nine CKDu cases (9%) from EL2 were recognized for the first time from EL1, EL2 locations, which were previously considered as non-endemic of the disease and associated with persistent albuminuria (ACR ≥ 30mg/g Cr). No CKDu cases were identified in non-endemic study locations in Matara (CM) and Nuwara Eliya (CN). Analysis of urinary biomarkers showed urinary KIM-1 and NGAL were significantly higher in new CKDu cases in EL1 and EL2. However, we also reported significantly higher KIM-1 and NGAL in apparently healthy farmers in EL 1 and EL 2 with comparison to both control groups. These observations may indicate possible early renal damage in absence of persistent albuminuria and potential capabilities of urinary KIM-1 and NGAL in early detection of renal injury

  5. Can You Anchor a Shimmering Nation State via Regional Indigenous Roots? Kim Scott talks to Anne Brewster about That Deadman Dance

    Directory of Open Access Journals (Sweden)

    Anne Brewster

    2011-10-01

    Full Text Available This interview focuses mainly on Kim Scott’s new novel That Deadman Dance which won the regional Commonwealth Writers Prize (Southeast Asian and Pacific region and the Miles Franklin Award. The topics of conversation include Scott’s involvement in the Noongar language project (and the relationship of this project to the novel, the novel itself, the challenges of writing in English, the resistance paradigm and indigenous sovereignty and nationalism.

  6. Beaudrie, Sara, Ducar, Cynthia, & Potowski, Kim (2014). Heritage language teaching: Research and practice. New York State, New York: McGraw Hill.

    OpenAIRE

    Florencia Henshaw

    2015-01-01

    This review introduces readers to Heritage language teaching: Research and practice, by Sara Beaudrie, Cynthia Ducar, and Kim Potowski, which is part of the “Directions in Second Language Learning” series. This handbook offers a comprehensive overview of key concepts, research findings, and pedagogical strategies to better meet the needs of heritage learners, and it underscores the importance of sociolinguistic issues and phenomena in heritage language instruction.

  7. Beaudrie, Sara, Ducar, Cynthia, & Potowski, Kim (2014. Heritage language teaching: Research and practice. New York State, New York: McGraw Hill.

    Directory of Open Access Journals (Sweden)

    Florencia Henshaw

    2015-12-01

    Full Text Available This review introduces readers to Heritage language teaching: Research and practice, by Sara Beaudrie, Cynthia Ducar, and Kim Potowski, which is part of the “Directions in Second Language Learning” series. This handbook offers a comprehensive overview of key concepts, research findings, and pedagogical strategies to better meet the needs of heritage learners, and it underscores the importance of sociolinguistic issues and phenomena in heritage language instruction.

  8. KIMS, CEDIA, and HS-CEDIA immunoassays are inadequately sensitive for detection of benzodiazepines in urine from patients treated for chronic pain.

    Science.gov (United States)

    Darragh, Alicia; Snyder, Marion L; Ptolemy, Adam S; Melanson, Stacy

    2014-01-01

    Patients treated for chronic pain may frequently undergo urine drug testing to monitor medication compliance and detect undisclosed prescribed or illicit drug use. Due to the increasing use and abuse of benzodiazepines, this class of medications is often included in drug screening panels. However, immunoassay-based methods lack the requisite sensitivity for detecting benzodiazepine use in this population primarily due to their poor cross-reactivity with several major urinary benzodiazepine metabolites. A High Sensitivity Cloned Enzyme Donor Immunoassay (HS-CEDIA), in which beta-glucuronidase is added to the reagent, has been shown to perform better than traditional assays, but its performance in patients treated for chronic pain is not well characterized. To determine the diagnostic accuracy of HS-CEDIA, as compared to the Cloned Enzyme Donor Immunoassay (CEDIA) and Kinetic Interaction of Microparticles in Solution (KIMS) screening immunoassays and liquid chromatography-tandem mass spectrometry (LC-MS/MS), for monitoring benzodiazepine use in patients treated for chronic pain. A study of the diagnostic accuracy of urine benzodiazepine immunoassays. The study was conducted at an academic tertiary care hospital with a clinical laboratory that performs urine drug testing for monitoring medication compliance in pain management. A total of 299 urine specimens from patients treated for chronic pain were screened for the presence of benzodiazepines using the HS-CEDIA, CEDIA, and KIMS assays. The sensitivity and specificity of the screening assays were determined using the LC-MS/MS results as the reference method. Of the 299 urine specimens tested, 141 (47%) confirmed positive for one or more of the benzodiazepines/metabolites by LC-MS/MS. All 3 screens were 100% specific with no false-positive results. The CEDIA and KIMS sensitivities were 55% (78/141) and 47% (66/141), respectively. Despite the relatively higher sensitivity of the HS-CEDIA screening assay (78%; 110

  9. Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation

    OpenAIRE

    Yoon TH; Kim MJ; Suh YJ; Lim EJ; Kim RK; Woo SJ; Hyun KH; Kwon DW; Yoon CH; Yoo KC; Lee SJ

    2012-01-01

    Ki-Chun Yoo1, Chang-Hwan Yoon1, Dongwook Kwon2, Kyung-Hwan Hyun1, Soo Jung Woo1, Rae-Kwon Kim1, Eun-Jung Lim1, Yongjoon Suh1, Min-Jung Kim1, Tae Hyun Yoon2, Su-Jae Lee11Laboratory of Molecular Biochemistry, 2Laboratory of Nanoscale Characterization and Environmental Chemistry, Department of Chemistry, Hanyang University, Seoul, Republic of KoreaBackground: Titanium dioxide (TiO2) has been widely used in many areas, including biomedicine, cosmetics, and environmental engineering. Recently, it ...

  10. Urinary Biomarkers KIM-1 and NGAL for Detection of Chronic Kidney Disease of Uncertain Etiology (CKDu among Agricultural Communities in Sri Lanka.

    Directory of Open Access Journals (Sweden)

    Pallagae Mangala C S De Silva

    2016-09-01

    Full Text Available Chronic Kidney Disease of uncertain etiology (CKDu is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that CKDu is a tubulointerstitial disease. Urine albumin or albumin-creatinine ratio is still being used as a traditional diagnostic tool to identify CKDu, but accuracy and prevalence data generated are questionable. Urinary biomarkers have been used in similar nephropathy and are widely recognised for their sensitivity, specificity and accuracy in determining CKDu and early renal injury. However, these biomarkers have never been used in diagnosing CKDu in Sri Lanka. Male farmers (n = 1734 were recruited from 4 regions in Sri Lanka i.e. Matara and Nuwara Eliya (farming locations with no CKDu prevalence and two CKDu emerging locations from Hambantota District in Southern Sri Lanka; Angunakolapelessa (EL1 and Bandagiriya (EL2. Albuminuria (ACR ≥ 30mg/g; serum creatinine based estimation of glomerular filtration rate (eGFR; creatinine normalized urinary kidney injury molecule (KIM-1 and neutrophil gelatinase-associated lipocalin (NGAL were measured. Fourteen new CKDu cases (18% from EL1 and nine CKDu cases (9% from EL2 were recognized for the first time from EL1, EL2 locations, which were previously considered as non-endemic of the disease and associated with persistent albuminuria (ACR ≥ 30mg/g Cr. No CKDu cases were identified in non-endemic study locations in Matara (CM and Nuwara Eliya (CN. Analysis of urinary biomarkers showed urinary KIM-1 and NGAL were significantly higher in new CKDu cases in EL1 and EL2. However, we also reported significantly higher KIM-1 and NGAL in apparently healthy farmers in EL 1 and EL 2 with comparison to both control groups. These observations may indicate possible early renal damage in absence of persistent albuminuria and potential capabilities of urinary KIM-1 and NGAL in early detection of renal

  11. Appendicitis acuta bij zeer jonge kinderen

    NARCIS (Netherlands)

    Kamphuis, S.J.; Tan, E.C.T.H.; Kleizen, K.; Aronson, D.C.; Blaauw, I. de

    2010-01-01

    Two girls, aged 8 months and 3 years respectively, presented with dehydration, vomiting and fever. The youngest girl was diagnosed first with gastroenteritis and was treated accordingly. Her condition deteriorated however, and she showed symptoms of a high bowel obstruction. Laparotomy revealed a pe

  12. Eosinofiele oesofagitis bij jonge mannen met voedselpassageklachten

    NARCIS (Netherlands)

    Thijs, W J; Koornstra, J J; Karrenbeld, A; Limburg, A J

    2005-01-01

    Three men, aged 20, 24 and 42 years, reported difficulties in passing food through the oesophagus. The diagnosis of eosinophilic oesophagitis was made after endoscopic investigation, laboratory tests and histological tests. In all three patients the symptoms disappeared: respectively spontaneously,

  13. Coeliakie: orale manifestaties op jonge leeftijd

    NARCIS (Netherlands)

    Brand, H.S.

    2015-01-01

    De gemiddelde Nederlandse tandarts heeft in de praktijk zo’n tien patiënten met coeliakie, en de meerderheid van deze patiënten weet zelf niet eens dat ze deze aandoening hebben. Coeliakie (glutengevoelige spruw) is een aandoening die klinisch tot expressie komt als de darm wordt blootgesteld aan

  14. Opnieuw sterfte van jonge bomen door woelmuizen

    NARCIS (Netherlands)

    Moraal, L.G.

    2002-01-01

    In het begin van de jaren negentig trad er behoorlijk veel schade op bij bosaanleg in het kader van de Randstadgroenstructuur en de set-aside regelingen in Groningen en Drenthe. De boompjes waren geplant op voormalige landbouwgrond. Door snelle verruiging van de vegetatie, ontstaat er voor woelmuize

  15. Appendicitis acuta bij zeer jonge kinderen

    NARCIS (Netherlands)

    Kamphuis, S.J.; Tan, E.C.T.H.; Kleizen, K.; Aronson, D.C.; Blaauw, I. de

    2010-01-01

    Two girls, aged 8 months and 3 years respectively, presented with dehydration, vomiting and fever. The youngest girl was diagnosed first with gastroenteritis and was treated accordingly. Her condition deteriorated however, and she showed symptoms of a high bowel obstruction. Laparotomy revealed a

  16. Experimental study for Yuen-Kim protocol of quantum key distribution with unconditional secure Bell's Theorem Without Inequalities for two Maximally Entangled Particles

    CERN Document Server

    Hirota, O; Sohma, M; Li Ming Wei; Tang, Z L; Liao, C C

    2002-01-01

    In this report, we simulate practical feature of Yuen-Kim protocol for quantum key distribution with unconditional secure. In order to demonstrate them experimentally by intensity modulation/direct detection(IMDD) optical fiber communication system, we use simplified encoding scheme to guarantee security for key information(1 or 0). That is, pairwise M-ary intensity modulation scheme is employed. Furthermore, we give an experimental implementation of YK protocol based on IMDD. A proof of Bell's theorem without inequalities for two maximally entangled particles is proposed using the technique of quantum teleportation. It follows Hardy's arguments for a non-maximally entangled state with the help of two auxiliary particles without correlation. The present proof can be tested by measurements with 100% probability.

  17. Changes of urinary L-FABP, KIM-1, NGAL and serum cystatin C in diabetic nephropathy and its clinical value%尿L-FABP、KIM-1、NGAL和血清cystatin C在糖尿病肾病中的变化及意义

    Institute of Scientific and Technical Information of China (English)

    梁雅灵; 杨茂君; 李衍辉; 黎秋晗; 黄炜; 徐勇

    2016-01-01

    Objective To investigate the changes of urinary liver-type fatty acid binding protein (L-FABP),kidney injury molecule-1 (KIM-1),neutrophil gelatinase-associated lipocalin (NGAL) and serum cystatin C in diabetic nephropathy and its clinical value.Methods A total of 118 patients diagnosed with type 2 diabetes in the Department of Endocrinology of Affiliated Hospital of Sichuan Medical University from October 2011 to October 2012 were recruited in this study.According to their urinary albumin-to-creatinine ratio(UACR),patients were divided into normal albuminuria group(n =45),microalbuminuria group (n =42),and macroalbuminuria group (n =43).A total of 41 healthy subjects were enrolled as normal control group(n =41).Enzyme-linked immunosorbent assays were used to measure the levels of urinary L-FABP,KIM-1 and NGAL.Turbidimetric inhibition immuno-assay was used to measure the expression of serum cystatin C.All the urinary indicators were adjusted by the level of urine creatinine.Changes of biomarkers in each group and their crrelations between UACR,eGFR were also compared.Results Compared with normal control group,urinary L-FABP and serum cystatin C were significantly increased in diabetic groups (x2 =77.959,104.003,all P < 0.05);urinary KIM-1 was also significantly increased (x2 =29.711,P < 0.05).Urinary NGAL was increased in microalbuminuria group and macroalbuminuria group compared with normal control group and normal albuminuria group(x2 =23.833,P < 0.05),but there were no significant difference between normal albuminuria group and normal control group.Urinary L-FABP,KIM-1,NGAL and serum cystatin C were positively correlated with UACR (r =0.719,0.427,0.327,0.726,all P < 0.01);while L-FABP and serum cystatin C were negatively correlated with eGFR (r =-0.301,-0.791,all P < 0.01).Conclusion Urinary L-FABP,KIM-1,NGAL and serum cystatin C are increased in early diabetic nephropathy,while urinary L-FABP and serum cystatin C may be the better biomarkers to

  18. The prevalence of musculoskeletal disorders and occupational risk factors in Kashan SAIPA automobile industry workers by key indicator method (KIM, 1390

    Directory of Open Access Journals (Sweden)

    2012-05-01

    Full Text Available Introduction: work related musculoskeletal disorders are the most wide spread type of occupational diseases among workers. Awkward body postures during work and manual material handling are among the most important risk factors of musculoskeletal disorders in different jobs. Due to importance of recognizing these factors prevalence and risk factor of work related musculoskeletal disorders, this research was aimed to study the among employees of Kashan City’s Saipa automobile industry in 2011. .Material and Method: This study is a descriptive-cross sectional study conducted among workers with manual material handling 37 activities and 84 work duties. To recognize musculoskeletal disorders, body map questionnaire was applied and occupational risk factors were evaluated using Key Index Method (KIM. Data was analyzed using SPSS and Excel software. .Result: Highest prevalence of musculoskeletal disorders was in low and upper back region (%92. Based on the results from KIM, workers in the installing the tire, shuttle-aided fitting of seat, and engine work station had higher risk level with the scores of 66, 52 and 52, respectively. Risk level among three individuals (%3.6 was at 1, 40 (%47.6 at 2, 38 (%45.2 risk level 3, and 3 (%3.6 at 4. .Conclusion: Awkward body posture, improper twisting and flexion of low back were major risk factor among worker doing manual material handling tasks. Regarding the high prevalence of musculoskeletal disorders, appropriate ergonomic interventions such as engineering and organization interactions can reduce this risk factors (posture, heavy load, duration, workplace conditions as much as the risk level reach to an acceptable level.

  19. THE ENTROPY OF A KIM BLACK HOLE AND THE NERNST THEOREM%Kim黑洞熵与能斯特定理

    Institute of Scientific and Technical Information of China (English)

    赵仁; 张丽春

    2001-01-01

    We start with Klein-Gordon equation on the background of the Kim black hole and calculate the free energy and entropy of a scalar field by the brick-wall method. It is shown that the entropy is not only related to the area of an outer horizon but also is a function of inner horizon's area. Taking some appr oximation, we can obtain that the entropy only is proportional to the area of an outer horizon. Further more, the entropy expressed by location parameter of the outer and inner horizon approaches zero, when the radiation temperature of a black hole approaches zero. This satisfies the Nernst theorem. It can be taken as Planck absolute entropy of a black hole.%从Kim 时空背景下的 Klein-Gordon 方程出发,利用 brick-wall 方法计算标量场的自由能和熵.得到标量场的熵不仅与黑洞的外视界面积有关,而且也是内视界面积的函数.所得结论,当取某种近似时,可得到熵只与外视界面积成正比的关系.并且表明,用内外视界位置参量表达的熵,在黑洞辐射温度趋于绝对零度时,黑洞的熵也趋于零,它满足能斯特定理,可视为黑洞的普朗克绝对熵.

  20. Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI-to-CKD transition.

    Science.gov (United States)

    Ko, Gang Jee; Grigoryev, Dmitry N; Linfert, Douglas; Jang, Hye Ryoun; Watkins, Tonya; Cheadle, Chris; Racusen, Lorraine; Rabb, Hamid

    2010-06-01

    Acute kidney injury (AKI) is being increasingly shown to be a risk factor for chronic kidney disease (CKD), but little is known about the possible mechanistic links. We hypothesized that analysis of the genomic signature in the repair stage after AKI would reveal pathways that could link AKI and CKD. Unilateral renal pedicle clamping for 45 min was performed in male C57BL/6J mice. Mice were euthanized at 3, 10, and 28 days after ischemia-reperfusion injury (IRI). Total RNA was isolated from kidney and analyzed using an Illumina mouse array. Among 24,600 tested genes, 242, 146, and 46 genes were upregulated at days 3, 10, and 28 after IRI, and 85, 35, and 0 genes were downregulated, respectively. Gene ontology analysis showed that gene expression changes were primarily related to immune and inflammatory pathways both early and late after AKI. The most highly upregulated genes late after AKI were hepatitis A virus cellular receptor 1 (Havcr1) and lipocalin 2 (Lcn2), which code for kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL), respectively. This was unexpected since they are both primarily potential biomarkers of the early stage of AKI. Furthermore, increases observed in gene expression in amiloride binding protein 1, vascular cell adhesion molecule-1, and endothelin 1 could explain the salt-sensitive hypertension that can follow AKI. These data suggested that 1) persistent inflammation and immune responses late after AKI could contribute to the pathogenesis of CKD, 2) late upregulation of KIM-1 and NGAL could be a useful marker for sustained renal injury after AKI, and 3) hypertension-related gene changes could underlie mechanisms for persistent renal and vascular injury after AKI.

  1. "The Day All of the Different Parts of Me Can Come Along": Intersectionality and U.S. Third World Feminism in the Poetry of Pat Parker and Willyce Kim.

    Science.gov (United States)

    Van Ausdall, Mimi Iimuro

    2015-01-01

    This article brings to light the poetry of Pat Parker and Willyce Kim, two key figures within the 1970s and '80s women in print movement. While Parker and Kim have been rightly placed within African-American and Asian-American histories, respectively, and working-class and lesbian-feminist literary histories, their work is most fully understood within the context of U.S. Third World Feminism. Through close readings of poetic form and content in addition to engagement with current debates about intersectionality as a methodology, the article links Kim and Parker's works to central contributions of U.S. Third World Feminism such as intersectionality and power across and within difference that continue to influence feminist theory today.

  2. 尿NGAL、KIM-1、L-FABP水平在脓毒症急性肾损伤早期诊断中的临床意义

    Institute of Scientific and Technical Information of China (English)

    许建宁; 徐玉辉; 蓝海兵

    2015-01-01

    目的 探讨尿NGAL、KIM-1、L-FABP水平在脓毒症急性肾损伤(AKI)早期诊断中的临床意义.方法 前瞻性的收集综合ICU的脓毒症患者91例,其中38例合并AKI,通过检测患者尿NGAL、KIM-1、L-FABP水平及血肌酐及尿素氨水平变化,对尿NGAL、KIM-1、L-FABP水平与血肌酐及尿素氮进行相关性分析,通过绘制受试者工作特征曲线(ROC),计算尿NGAL、KIM-1、L-FABP水平在早期诊断脓毒症合并AKI中的敏感性及特异性.结果 观察组患者与对照组相比,尿NGAL、L-FABP水平在诊断前48 h即出现显著升高(P<0.05),尿KIM-1水平在在诊断前24 h即出现显著升高(P<0.05);尿NGAL、KIM-1、L-FABP水平与血肌酐、尿素氮呈正相关性;ROC曲线分析发现,诊断前24h,尿NGAL、L-FABP水平在诊断脓毒症合并AKI时具有较高的敏感性及特异性,诊断前0h,尿KIM-1水平在诊断脓毒症合并AKI时具有较高的敏感性及特异性.结论 尿NGAL、KIM-1、L-FABP水平均在脓毒症早期出现显著升高,可以作为脓毒症AKI早期诊断的指标.

  3. Why Stochastic Modeling is Essential in Analyzing Interdicted Transportation Network Performance

    Science.gov (United States)

    1989-06-01

    Guro -Gu, Si-Heung 1 Dong, HanYang Apt. 5-1107 Seoul, Korea 11. CPT. Kim, Suk Hwan SMC 2318 Naval Postgraduate School Monterey, alifornia 93943-5000 12. Library 130-02 Korea Military Academy Gong-Reung Dong, 556-21 Seoul, Korea 61

  4. 尿KIM-1对心脏术后急性肾损伤的早期诊断价值

    Institute of Scientific and Technical Information of China (English)

    余春俊; 龚明辉; 谭劲淘; 涂星强; 王涛; 邹小明

    2014-01-01

    目的:评估尿肾损伤分子1(KIM-1)在心脏术后急性肾损伤(AKI)早期诊断中的应用价值。方法通过计算机检索Medline、Cochrane图书馆、EMBASE、Web of Science Database、Elsevier Science Direct Database、 CNKI、VIP数据库、万方数据库,查阅KIM-1早期诊断心脏术后AKI的临床试验,采用诊断精确性研究的质量评估方法(QUADAS)评价文献质量,Stata12.0和Meta-Disc1.4软件进行数据分析。结果共纳入9篇符合标准的诊断性研究,QUADAS得分均﹥9分,Spearman异质性检验r=0.622、 P=0.074,发表偏倚Egger线性回归法定量分析P=0.001;敏感性分析的合并敏感度为0.87(95%CI为0.81~0.92)、P=0.5776、I2=0,特异度为0.78(95%CI为0.74~0.81)、P=0.000、I2=87.1%,阳性似然比为4.07(95%CI为2.70~7.12)、P=0.000、I2=78.2%,阴性似然比为0.19(95%CI为0.13~0.28)、P=0.7303、I2=0.0%,诊断比值比为28.03(95%CI为15.95~49.27)、P=0.8640、I2=0,汇总受试者工作曲线下面积(AUC)为0.9155。结论尿KIM-1在心脏术后(6~12h)诊断AKI的准确性较高。

  5. Urinary Vitamin D Binding Protein and KIM-1 Are Potent New Biomarkers of Major Adverse Renal Events in Patients Undergoing Coronary Angiography.

    Directory of Open Access Journals (Sweden)

    Lyubov Chaykovska

    Full Text Available Vitamin-D-binding protein (VDBP is a low molecular weight protein that is filtered through the glomerulus as a 25-(OH vitamin D 3/VDBP complex. In the normal kidney VDBP is reabsorbed and catabolized by proximal tubule epithelial cells reducing the urinary excretion to trace amounts. Acute tubular injury is expected to result in urinary VDBP loss. The purpose of our study was to explore the potential role of urinary VDBP as a biomarker of an acute renal damage.We included 314 patients with diabetes mellitus or mild renal impairment undergoing coronary angiography and collected blood and urine before and 24 hours after the CM application. Patients were followed for 90 days for the composite endpoint major adverse renal events (MARE: need for dialysis, doubling of serum creatinine after 90 days, unplanned emergency rehospitalization or death.Increased urine VDBP concentration 24 hours after contrast media exposure was predictive for dialysis need (no dialysis: 113.06 ± 299.61 ng/ml, n = 303; need for dialysis: 613.07 ± 700.45 ng/ml, n = 11, Mean ± SD, p<0.001, death (no death during follow-up: 121.41 ± 324.45 ng/ml, n = 306; death during follow-up: 522.01 ± 521.86 ng/ml, n = 8; Mean ± SD, p<0.003 and MARE (no MARE: 112.08 ± 302.00 ng/ml, n = 298; MARE: 506.16 ± 624.61 ng/ml, n = 16, Mean ± SD, p<0.001 during the follow-up of 90 days after contrast media exposure. Correction of urine VDBP concentrations for creatinine excretion confirmed its predictive value and was consistent with increased levels of urinary Kidney Injury Molecule-1 (KIM-1 and baseline plasma creatinine in patients with above mentioned complications. The impact of urinary VDBP and KIM-1 on MARE was independent of known CIN risk factors such as anemia, preexisting renal failure, preexisting heart failure, and diabetes.Urinary VDBP is a promising novel biomarker of major contrast induced nephropathy-associated events 90 days after contrast media exposure.

  6. Study on the Muon Background in the Underground Laboratory of KIMS%KIMS地下实验中μ子本底的研究

    Institute of Scientific and Technical Information of China (English)

    朱敬军; S.S.Myung; M.J.Lee; S.C.Kim; S.K.Kim; J.I.Lee; Y.D.Kim; M.J.Hwang; Y.J.Kwon; I.S.Hahn; H.J.Kim; 康克军; 李元景; 李金; J.W.Kwak; H.Bhang; S.Y.Kim; H.S.Lee; J.Lee

    2005-01-01

    KIMS是寻找和研究暗物质WIMP的实验组.在WIMP寻找实验中,μ子是十分重要的一种本底.我们对地下700m深的Yangyang实验室内的μ子通量进行了测量.介绍了μ子探测器的结构和性能测试.描述了对μ子入射位置和角度分布的分析,并进行了蒙特卡罗模拟.实验室内的μ子通量测量值为(7.0±0.4)×10-8/s/cm2/sr.%KIMS is a group aiming at the search for WIMP. In WIMP search experiment, the muon is one important background. We measure the muon flux in Yangyang laboratory where is located at 700m underground. The structure and performance test of muon detector is described. The analysis on muon hit position and angle distribution has been performed. The simulations of muon flux have been done. The muon flux in the laboratory is found to be about (7.0±0.4)×10-8/s/cm2/sr.

  7. Evaluation of KIMS immunoassays on a cobas c 501 analyzer for drugs of abuse and ethyl glucuronide testing in urine for forensic abstinence control.

    Science.gov (United States)

    Neukamm, Merja A; Bahrami, Arsham; Auwärter, Volker; Mehne, Felix M P; Höss, Eva

    2016-12-26

    For the medico-psychological assessment (MPA) during driving licence re-granting in Germany, abstinence control including urine samples is required. In these programmes, even small amounts of markers for drug or alcohol abuse have to be detected. Thus, the concentrations of the target compounds are very low, and, in consequence, the sensitivity of the applied screening method has to be much higher than for clinical use. Modified drugs of abuse and ethyl glucuronide immunoassays on a Roche cobas c 501 analyzer were evaluated for precision, accuracy, onboard calibration stability, cross reactivity, sensitivity, and specificity using authentic urine samples. Precision (intra-day and inter-day relative standard deviation (RSD) and accuracy (bias) at three concentrations were 12% or lower for all parameters. The calibrations remained stable (deviations amphetamines (21 days). Satisfactory cross reactivity was determined for the relevant analytes and also for several new psychoactive substances (NPS). The sensitivity was 100% for all parameters except methadone metabolite EDDP (92%) and fully met the sensitivity criteria for MPA urine testing. The presented kinetic interaction of microparticles in a solution (KIMS) immunoassays on a cobas c 501 thus provide a new method to reliably detect drug or alcohol consumption in abstinence control programmes requiring high sensitivity. Copyright © 2016 John Wiley & Sons, Ltd.

  8. Nam obeshtshajut peregrev / Kim Kosmatshov

    Index Scriptorium Estoniae

    Kosmatshov, Kim

    2006-01-01

    Ajakirjas The Economist ilmunud artiklist, milles käsitletakse Eesti ja Läti majandusedu ning viidatakse võimalikele ohtudele tulevikus. Peamiseks probleemiks nimetatakse mõlema riigi puhul inflatsiooni kasvu

  9. Nam obeshtshajut peregrev / Kim Kosmatshov

    Index Scriptorium Estoniae

    Kosmatshov, Kim

    2006-01-01

    Ajakirjas The Economist ilmunud artiklist, milles käsitletakse Eesti ja Läti majandusedu ning viidatakse võimalikele ohtudele tulevikus. Peamiseks probleemiks nimetatakse mõlema riigi puhul inflatsiooni kasvu

  10. New Impetus

    Institute of Scientific and Technical Information of China (English)

    YAN WEI

    2010-01-01

    @@ North Korean leader Kim Jong Ⅱ's recent visit to China gave new impetus to the two countries' bilateral relations, while helping strengthen their consensus on addressing the Korean Peninsula nuclear issue through the six-party talks.

  11. Mis toimub Põhja-Koreas? / Aadu Hiietamm

    Index Scriptorium Estoniae

    Hiietamm, Aadu, 1954-

    2004-01-01

    Infoagentuuri UPI teatel võib Põhja-Korea liider Kim Jong-il olla surnud, avalikest kohtadest on hakatud maha võtma tema portreesid. Põhja-Korea infoagentuur eitab seda. Ekspertide versioonidest Põhja-Koreas toimuva kohta

  12. Photophysical Properties of Aromatic and Antiaromatic Porphyrinoids

    Science.gov (United States)

    2011-04-14

    Chem. B, 2007, 111, 2138. 18 List of Publications 1. Large Porphyrin Squares from the Self-Assembly of meso- Triazole -Appended L-Shaped meso–meso...Linked ZnII–Triporphyrins: Synthesis and Efficient Energy Transfer  Chihiro Maeda, Pyosang Kim, Sung Cho, Jong Kang Park, Jong Min Lim, Dongho Kim...Characterization of Tri(Cyclopentaphenanthrene)-Derived Nanoparticles: A Template Free Synthesis of Hollow Colloidosomes.  Shanmugam Easwaramoorthi, Pyosang

  13. Fabrication Procedure for Rugged and Breathable Forms of Stretchable Electronics with Adherent and Composite Substrates

    OpenAIRE

    2014-01-01

    Authors: Kyung-In Jang, Sang Youn Han, Sheng Xu, Kyle E. Mathewson, Yihui Zhang, Jae-Woong Jeong, Gwang-Tae Kim, R. Chad Webb, Jung Woo Lee, Thomas J. Dawidczyk, Rak Hwan Kim, Young Min Song, Woon-Hong Yeo, Stanley Kim, Huanyu Cheng, Sang Il Rhee, Jeahoon Chung, Byunggik Kim, Ha Uk Chung, Dongjun Lee, Yiyuan Yang, Moongee Cho, John G. Gaspar, Ronald Carbonari, Monica Fabiani et al. ### Abstract We introduce materials and composite designs for thin, breathable, soft electronics that ca...

  14. The Protective Effect of the Ethanol Leaf Extract of Andrographis Paniculata on Cisplatin-Induced Acute Kidney Injury in Rats Through nrf2/KIM-1 Signalling Pathway.

    Science.gov (United States)

    Adeoye, Bisi Olajumoke; Asenuga, Ebunoluwa Racheal; Oyagbemi, Ademola Adetokunbo; Omobowale, Temidayo Olutayo; Adedapo, Adeolu A

    2017-09-12

    The ethanol leaf extract of Andrographis paniculata was used to ameliorate the renal toxicity induced by cisplatin in 28 rats divided into four groups of seven rats per group. Group A received normal saline for the duration of the experiment. Group B animals were treated with cisplatin (10 mg/kg i.p) on day 1 and 3 days after received normal saline for the next 7 days while groups C and D animals also received 10 mg/kg dose of cisplatin on day 1 but after 3 days were then respectively treated with 200 and 400 mg/kg doses of the extract of Andrographis paniculata for the remaining 7 days through oral administration. Serum chemistry was used for the determination of markers of oxidative stress, anti-oxidant enzymes, serum biomarkers etc. Histopathology and immunohistochemistry were also carried out. Results showed that all oxidative stress markers assayed were significantly increased in group B animals but reverse is the case for groups C and D. On the other hand, antioxidant enzymes assayed experienced significant increase for groups C and D while these parameters experienced significant decrease for group B animals. Histopathology showed severe infiltration of inflammatory cells into renal tissues of group B animals whereas for groups C and D animals, only moderate glomerular degeneration was noted. In immunohistochemistry, while there is higher expression of KIM-1 for group B, there was a lower expression in groups C and D. Again, there was lower expression of Nrf2 for group B but higher expressions in groups C and D animals. © Georg Thieme Verlag KG Stuttgart · New York.

  15. Dextran-b-poly(L-histidine copolymer nanoparticles for pH-responsive drug delivery to tumor cells

    Directory of Open Access Journals (Sweden)

    Hwang JH

    2013-08-01

    Full Text Available Jong-Ho Hwang,1,2 Cheol Woong Choi,1 Hyung-Wook Kim,1 Do Hyung Kim,3 Tae Won Kwak,3 Hye Myeong Lee,3 Cy Hyun Kim,3 Chung Wook Chung,3 Young-Il Jeong,3 Dae Hwan Kang1,3 1Department of Internal Medicine, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea; 2Department of Internal Medicine, Busan Medical Center, Yeonje-gu, Busan, Republic of Korea; 3National Research and Development Center for Hepatobiliary Disease, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea Purpose: Nanoparticles based on stimuli-sensitive drug delivery have been extensively investigated for tumor targeting. Among them, pH-responsive drug targeting using pH-sensitive polymers has attracted attention because solid tumors have an acidic environment. A dextran-b-poly(L-histidine (DexPHS copolymer was synthesized and pH-responsive nanoparticles were fabricated for drug targeting. Methods and results: A DexPHS block copolymer was synthesized by attaching the reductive end of dextran to the amine groups of poly(L-histidine. pH-responsive nanoparticles incorporating doxorubicin were fabricated and studied in HuCC-T1 cholangiocarcinoma cells. Synthesis of DexPHS was confirmed by 1H nuclear magnetic resonance spectroscopy, with specific peaks of dextran and PHS observed at 2–5 ppm and 7.4–9.0 ppm, respectively. DexPHS nanoparticles showed changes in particle size with pH sensitivity, ie, the size of the nanoparticles increased at an acidic pH and decreased at a basic pH. DexPHS block copolymer nanoparticles incorporating doxorubicin were prepared using the nanoprecipitation dialysis method. The doxorubicin release rate was increased at acidic pH compared with basic pH, indicating that DexPHS nanoparticles have pH-sensitive properties and that drug release can be controlled by variations in pH. The antitumor activity of DexPHS nanoparticles incorporating doxorubicin were studied using HuCC-T1

  16. Kant en los problemas de filosofía de la mente contemporánea entre D. Davidson y J. Kim: un argumento a favor del Monismo Anómalo

    OpenAIRE

    Martínez Gómez, José Nicolás

    2016-01-01

    El Monismo Anómalo que Donald Davidson postuló como posible derrotero a propósito de los problemas latentes en filosofía de la mente contemporánea ha sido víctima de serias críticas, en especial aquellas planteadas por Jaegwon Kim. Sin embargo, una lectura que incluya las referencia que Davidson hizo del proyecto que Kant desarrolló en la Tercera Antinomia de la Razón Pura puede servir para ofrecer una lectura a favor de su proyecto.

  17. Kim Brandt, Kingdom of Beauty: Mingei and the Politics of Folk Art in Imperial Japan (Le royaume de la beauté : le Mingei et la politique de l’art populaire dans le Japon impérial

    OpenAIRE

    Sablé-Denans, Nadia

    2014-01-01

    L’exposition proposée par le Musée du quai Branly en 2008-2009 sur les objets et l’esthétique mingei a donné l’occasion de parcourir les derniers ouvrages parus sur le sujet. La monographie de Kim Brandt, professeure associée en histoire japonaise à l’Université Columbia, mérite sa place parmi ces lectures. Chronologiquement organisé, Kingdom of Beauty expose l’histoire du mouvement pour les Arts populaires de ses origines, dans les années 1920, à la fin de la Seconde Guerre mondiale, en lien...

  18. Comparative toxicity and biodistribution of copper nanoparticles and cupric ions in rats

    Directory of Open Access Journals (Sweden)

    Lee IC

    2016-06-01

    Full Text Available In-Chul Lee,1 Je-Won Ko,1 Sung-Hyeuk Park,1 Je-Oh Lim,1 In-Sik Shin,1 Changjong Moon,1 Sung-Hwan Kim,2 Jeong-Doo Heo,3 Jong-Choon Kim1 1College of Veterinary Medicine BK21 Plus Project Team, Chonnam National University, Gwangju, 2Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeongeup, 3Gyeongnam Department of Environment and Toxicology, Korea Institute of Toxicology, Gyeongnam, Republic of Korea Abstract: Despite widespread use and prospective biomedical applications of copper nanoparticles (Cu NPs, their biosafety issues and kinetics remain unclear. Thus, the aim of this study was to compare the detailed in vivo toxicity of Cu NPs and cupric ions (CuCl2; Cu ions after a single oral dose. We determined the physicochemical characteristics of Cu NPs, including morphology, hydrodynamic size, zeta potential, and dissolution in gastric (pH 1.5, vehicle (pH 6.5, and intestinal (pH 7.8 conditions. We also evaluated the kinetics of Cu following a single equivalent dose (500 mg/kg of Cu NPs and Cu ions. Cu NPs had highest dissolution (84.5% only in gastric conditions when compared with complete dissolution of Cu ions under various physiological milieus. Kinetic analysis revealed that highest Cu levels in blood and tested organs of Cu NP-treated rats were 15%–25% lower than that of Cu ions. Similar to the case of Cu ions, Cu levels in the tested organs (especially liver, kidney, and spleen of Cu NP-treated rats increased significantly when compared with the vehicle control. However, delay in reaching the highest level and biopersistence of Cu were observed in the blood and tested organs of Cu NP-treated rats compared with Cu ions. Extremely high levels of Cu in feces indicated that unabsorbed Cu NPs or absorbed Cu ions were predominantly eliminated through liver/feces. Cu NPs exerted apparent toxicological effects at higher dose levels compared with Cu ions and showed sex-dependent differences in mortality, biochemistry, and

  19. Korean Affairs Report No. 299

    Science.gov (United States)

    2007-11-02

    a special research institute in the Pyongyang area, staffed by approximately 50 highly-trained experts in microbiology . These researchers have...Myong-ku h$ The delegation of Ecuador : Kim Hwan comrade Yu Yong-kol " The delegation of Zaire: Ch’oe Chae-u comrade Pang Ch’ol-kap functionary of a...NODONG SINMUN 24 Apr 82 p 4] KIM MEETS DELEGATIONS—The following were present on 24 April when Kim Il-song met the Ecuador Committee to support the

  20. On Films Directed by Ki-duk Kim and Dual Cultural Context in Criticism%金基德电影及批评的二元文化语境

    Institute of Scientific and Technical Information of China (English)

    裴媛媛

    2015-01-01

    By adopting symbolic signs in his independent films, Ki-duk Kim combines mysteries in Eastern culture and rational reflection in Western culture. He aims at the western European market, and attempts to impose Eastern cultural elements to the Westerners, causing a wide range of criticism made by criticizers in his own country. By an analysis of the films directed by Ki-duk Kim, it is proposed that the dual cultural context makes it possible that people can expect the co-existence of multi-cultural elements.%金基德的独立电影通常采用符号化的象征手法,将东方文化的神性感知与西方文化的理性反思融合在一起。他立足于西欧市场,试图把东方文化元素贩卖到西方去,这看似一种国际视野,却惹来本土批论家的一片唏嘘。综观金基德的电影创作及批评接受,二元文化语境的双重叙事,为实现多元文化的通约共存,提供了一种理论预设和期待可能性。

  1. A Significant Visit

    Institute of Scientific and Technical Information of China (English)

    SHI YONGMING

    2010-01-01

    @@ North Korean leader KimJong Ⅱ paid a visit to China from May 3-7. The trip was on the agenda as early as last January, when Wang Jiarui, head of the International Department of the Communist Party of China Central Committee visited North Korea and delivered Chinese President Hu Jintao's invitation to Kim.

  2. Pyongyang's Choice

    Institute of Scientific and Technical Information of China (English)

    SHI YONGMING

    2010-01-01

    @@ The recent leadership adjustment in the Democratic People's Republic of Korea(DPRK)was one of the world's most attention-grabbing affairs.A conference for the ruling Workers' Party of Korea(WPK)was successfully held on September 28.A day before the conference,Kim Jong II,the DPRK's top leader,issued an order that promoted a group of military officers.Kim's youngest son Kim Jong Un was appointed a general.These activities prove the DPRK has established its new leadership.

  3. Abielu, perekonna ja õnnistuse tähendus / Chung Hwan Kwak

    Index Scriptorium Estoniae

    Kwak, Chung Hwan

    2002-01-01

    Ettekanne Rahvusvahelise ja Relgioonidevahelise Föderatsiooni Maailmarahu eest (IIFWP) Tallinnas peetud seminaril "Riigi uuendamine: perekondi tugevdavate, meie noori kasvatavate ja ühiskonda taasehitavate printsiipide ja praktikate uurimine" : lühendatult

  4. Abielu, perekonna ja õnnistuse tähendus / Chung Hwan Kwak

    Index Scriptorium Estoniae

    Kwak, Chung Hwan

    2002-01-01

    Ettekanne Rahvusvahelise ja Relgioonidevahelise Föderatsiooni Maailmarahu eest (IIFWP) Tallinnas peetud seminaril "Riigi uuendamine: perekondi tugevdavate, meie noori kasvatavate ja ühiskonda taasehitavate printsiipide ja praktikate uurimine" : lühendatult

  5. The significance of urine microscopy and urinary kidney injury molecular 1 and neutrophil gelatinase associated lipocalin in patients with primary kidney disease complicated with acute tubular interstitial lesion%尿沉渣联合尿KIM-1、NGAL在诊断原发性肾脏病合并急性肾小管间质病变中的意义

    Institute of Scientific and Technical Information of China (English)

    刘亚红; 苑丽华

    2015-01-01

    目的 观察原发性慢性肾脏病(CKD)合并急性肾小管间质病变(ATIL)时尿沉渣积分情况和尿肾损伤因子1(KIM-1)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平的变化,以期早期、准确发现ATIL.方法 经临床和病理确诊为CKD并发ATIL病例52例,对照组为无急性肾损伤(AKI)的原发性CKD患者33例,15例健康人为正常对照组.比较三组尿KIM-1、NGAL水平与尿沉渣积分的不同.结果 ①三组的尿KIM-1、NGAL水平和尿沉渣积分相比较,原发性CKD并发ATIL患者均高于其他两组(P<0.05),无AKI的CKD患者高于健康对照组(P<0.05);②尿KIM-1、NGAL水平与尿沉渣评分呈正相关(r=0.711,0.683,P<0.05),三者又均与CKD患者的ATIL严重程度呈正相关(r=0.892,0.735,0.745,P<0.05);③N-乙酰-β-D-氨基葡萄糖苷酶(NAG)、视黄醇结合蛋白(RBP)和α1-微球蛋白(α1-MG)尚在正常范围的患者尿KIM-1、NGAL水平已有升高,肾脏组织病理证实存在不同程度的ATIL;④尿KIM-1、NGAL、光抑素C(CysC)、NAG诊断ATIL的ROC曲线下面积大于尿RBP、α1-MG.尿沉渣诊断ATIL的受试者工作(ROC)曲线下面积为84%.尿KIM-1、NGAL联合尿沉渣积分诊断ATIL的准确性达100%.结论 尿沉渣联合尿KIM-1、NGAL可作为诊断原发性CKD并发ATIL的早期、无创、敏感的指标.%Objectives We explored urinary sediment scoring on the basis of the number of renal tubular epithelial cells and granular casts and the urinary level of KIM-1 and NGAL in patients with primary and chronic kidney disease (CKD) complicated with acute tubular interstitial lesion(ATIL),in order to find tubular interstitial injury early and accurately.Methods Data of 52 cases of primary CKD with ATIL and of 33 cases of CKD without acute kidney injury (AKI)admitted to Second Affiliated Hospital of Xingtai Medical College from February 2012 to February 2013 were analyzed.Urinary sediment scoring on the basis of the number of renal tubular epithelial

  6. Jonge kalveren: uiterst gevoelig voor para-tbc besmetting

    NARCIS (Netherlands)

    Boxem, Tj.

    1997-01-01

    Para-tuberculose is een bacterieziekte die zich bij koeien pas op latere leeftijd, zo tussen het derde en zesde levensjaar, manifesteert. Het uitbreken van deze zeer besmettelijke ziekte (ontsteking darmwand) gaat gepaard met een niet of nauwelijks testoppen diarree. Minder melk en een toenemende ve

  7. Jong lesers se identifisering met karakters: skryfteorie en -praktyk

    OpenAIRE

    F. Greyling

    2005-01-01

    Young readers’ identification with characters: the theory and practice of creative writing It is generally acknowledged that reader identification with characters contributes to readers’ involvement in the text and the subsequent pleasure derived from reading stories. It seems that establishing a relationship with the implied reader of the text comes naturally for successful authors. There is, however, a lack of coherent theory on reader identification with characters which can be used in the...

  8. Behoefte aan opvoedingsondersteuning van ouders van jonge kinderen

    NARCIS (Netherlands)

    Asscher, Jessica; Hermanns, Jo; Dekovic, M.

    2008-01-01

    The present study examines the role of similarity in music preferences in the formation and discontinuation of friendships over a one-year period. Questionnaire data were gathered from 283 Dutch same-sex mutual best friends (Mean age = 12.97) in two waves with a one-year interval. Results show consi

  9. Jonge kalveren: uiterst gevoelig voor para-tbc besmetting

    NARCIS (Netherlands)

    Boxem, Tj.

    1997-01-01

    Para-tuberculose is een bacterieziekte die zich bij koeien pas op latere leeftijd, zo tussen het derde en zesde levensjaar, manifesteert. Het uitbreken van deze zeer besmettelijke ziekte (ontsteking darmwand) gaat gepaard met een niet of nauwelijks testoppen diarree. Minder melk en een toenemende

  10. De uitstroom van jonge fiscalisten uit het hoger onderwijs

    NARCIS (Netherlands)

    de Graaf, D.; Berkhout, P.H.G.

    2006-01-01

    In 1998 was de arbeidsmarkt van fiscalisten krap. De Nederlandse Orde van Belastingadviseurs (NOB) wilde daarom beter zicht op de arbeidsmarkt van hoog opgeleide fiscalisten die pas het hoger onderwijs hadden verlaten. SEO Economisch Onderzoek heeft destijds die arbeidsmarkt geschetst. De opzet van

  11. Achtergronden van taalachterstanden bij jonge kinderen in Oost-Groningen

    NARCIS (Netherlands)

    Poolman, B.G.; Minnaert, A.E.M.G.; Leseman, P.P.M.; Doornenbal, J.M.

    2015-01-01

    The Eastern part of Groningen is a rural area in the Netherlands with traditionally a large number of children with language delays. Recent review research confirmed this. Although the knowledge about backgrounds of language delays in children in socially deprived areas is enormous, pupils in this a

  12. Achtergronden van taalachterstanden bij jonge kinderen in Oost-Groningen

    NARCIS (Netherlands)

    Poolman, B.G.; Minnaert, A.E.M.G.; Leseman, P.P.M.; Doornenbal, J.M.

    2015-01-01

    The Eastern part of Groningen is a rural area in the Netherlands with traditionally a large number of children with language delays. Recent review research confirmed this. Although the knowledge about backgrounds of language delays in children in socially deprived areas is enormous, pupils in this a

  13. Oude verhalen voor jonge lezers : Over bewerkingen van literaire klassiekers

    NARCIS (Netherlands)

    Parlevliet, Sanne

    2011-01-01

    Het hertalen en bewerken van literaire meesterwerken is een oude traditie. Zo wordt het literaire erfgoed doorgegeven aan volgende generaties. De redenen die hedendaagse hertalers geven voor het bewerken van klassieke teksten komen overeen met de redenen die daar meer dan een eeuw geleden voor

  14. Jong lesers se identifisering met karakters: skryfteorie en -praktyk

    Directory of Open Access Journals (Sweden)

    F. Greyling

    2005-07-01

    Full Text Available Young readers’ identification with characters: the theory and practice of creative writing It is generally acknowledged that reader identification with characters contributes to readers’ involvement in the text and the subsequent pleasure derived from reading stories. It seems that establishing a relationship with the implied reader of the text comes naturally for successful authors. There is, however, a lack of coherent theory on reader identification with characters which can be used in the teaching of creative writing. This article combines insights gained from various disciplines in order to develop a coherent theory of the phenomenon of reader identification. Of special interest are the results of reader-response research regarding the relation between individuals’ development phase and identification with characters. Some of the possibilities which the writer can utilise to establish a relationship with the reader and influence the nature of reader identification with characters are the choice of characters and their depiction in the text, the narrative strategy and the use of viewpoint.

  15. Inname aan zware metalen en nitraat door jonge kinderen

    NARCIS (Netherlands)

    Asselt, van E.D.; Mul, de A.; Traag, W.A.; Klaveren, van J.D.

    2008-01-01

    Innameberekeningen zijn uitgevoerd voor zware metalen, nitraat en zout op basis van metingen uit een duplicaat voedingsstudie bij baby's en deze zijn vergeleken met innameberekeningen op basis van monitoringsdata uit de KAP-databank. Voor de duplicaat voedingen is gebruik gemaakt van data verzameld

  16. De bijdrage van leefstijl aan gewichtsstijging bij jong volwassenen

    NARCIS (Netherlands)

    Wendel-Vos GCW; Nooyens ACJ; Schuit AJ; PZO

    2004-01-01

    In this report, the contribution of lifestyle to weight gain in young adults is addressed. Aspects of lifestyle factors associated with weight gain differ between men and women. For example, among men consumption of savoury snacks seemed to be associated with weight gain, whereas among women

  17. Oude verhalen voor jonge lezers : Over bewerkingen van literaire klassiekers

    NARCIS (Netherlands)

    Parlevliet, Sanne

    2011-01-01

    Het hertalen en bewerken van literaire meesterwerken is een oude traditie. Zo wordt het literaire erfgoed doorgegeven aan volgende generaties. De redenen die hedendaagse hertalers geven voor het bewerken van klassieke teksten komen overeen met de redenen die daar meer dan een eeuw geleden voor werde

  18. Vriendschappen tussen jong en oud in 25 Europese landen

    NARCIS (Netherlands)

    P.A. Dykstra (Pearl); M. Fleischmann (Maria)

    2016-01-01

    markdownabstractSummary Cross-age friendships in 25 European countries This paper focuses on individual and country-level circumstances shaping friendships between young and old to gain insight into conditions for intergenerational solidarity. Using European Social Survey data, findings show that

  19. De bijdrage van leefstijl aan gewichtsstijging bij jong volwassenen

    NARCIS (Netherlands)

    Wendel-Vos GCW; Nooyens ACJ; Schuit AJ; PZO

    2004-01-01

    In this report, the contribution of lifestyle to weight gain in young adults is addressed. Aspects of lifestyle factors associated with weight gain differ between men and women. For example, among men consumption of savoury snacks seemed to be associated with weight gain, whereas among women consump

  20. Ajateenistusest, ausalt! / Kim Järvepõld

    Index Scriptorium Estoniae

    Järvepõld, Kim

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke, 9. apr. 2007, lk. 7. Autor leiab, et põhiseaduslik nõue, mille järgi on kõik Eesti kodanikud kohustatud osa võtma riigikaitsest, pole vastavuses tegeliku olukorraga, ning arvab, et kohustuslik ajateenistus tuleb kaotada või viia kooskõlla põhiseadusega

  1. Ajateenistusest, ausalt! / Kim Järvepõld

    Index Scriptorium Estoniae

    Järvepõld, Kim

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke, 9. apr. 2007, lk. 7. Autor leiab, et põhiseaduslik nõue, mille järgi on kõik Eesti kodanikud kohustatud osa võtma riigikaitsest, pole vastavuses tegeliku olukorraga, ning arvab, et kohustuslik ajateenistus tuleb kaotada või viia kooskõlla põhiseadusega

  2. Retarderi na teškim vozilima

    Directory of Open Access Journals (Sweden)

    Joško Rapanić

    2012-10-01

    Full Text Available The objective of all the braking systems fitted in vehicles isto reduce the speed, as well as to keep them at a standstill. Inorder to increase the active road traffic safety, the experts inthe leading vehicle manufacturer companies are trying from day to day to find a more efficient solution of the highest possiblequality. Braking problems, i.e. problems of stopping the vehiclesare closely related to time, forces, momentum, mass andother physical quantities. This is best seen in the braking ofheavy duty vehicles, trucks, buses, where the braking efficacyis questionable due to high inertia forces caused by heavyweight and more recently relatively high speeds. Such vehiclesare fitted with system of brakes that operate on compressed airor combination of pneumatics and hydraulics, since the driverhas not got enough power to achieve appropriate braking effect.However, the biggest problems occur by trucks runningdownhill, when the braking system is operated continuously fora longer period of time. This causes heating and overheating ofthe system elements ("fading", thus reducing the braking effect.In extreme cases, particularly if the system is poorly maintained,it can eventually fail completely.Because of the mentioned reasons for difficulties in brakingof trucks, such vehicles have been recently fitted with anauxiliary slow-down system. This system is completely independentfromthe main one on the wheels and is used exclusivelyfor slowing down or for maintaining of speed.

  3. MICROBIOLOGICAL STUDY OF CSOM AT KIMS - AMALAPURAM

    Directory of Open Access Journals (Sweden)

    Nagaraja

    2016-01-01

    Full Text Available BACKGROUND In India, Chronic Suppurative Otitis Media (CSOM is a major public-health problem with a high-prevalence rate. Several organisms have been implicated in the causation of CSOM, posing a challenge to the management. This is further complicated by the problem of emerging antibiotic-resistant bacterial strains. OBJECTIVE We undertook the present study to identify the causative organisms in CSOM and their susceptibility patterns to antibiotics in a rural teaching hospital in South India. METHODS A total number of 100 ear swabs were bacteriologically investigated for the present study. All the swabs collected from patients with clinical diagnosis of CSOM visiting the ENT outpatient department of a rural teaching hospital from December 2014 to May 2015. All these are new patients who did not have recent treatment with antibiotics either locally or systemically. Another group of 30 ear swabs were collected from healthy individuals with no history of ear discharged for control study. RESULTS Of the 100 patients, 45 were males. Out of 100 swabs cultured, 95% were culture positive and 5% were culture negative. Of the culture positive cases, 70% were aerobes, 25% were anaerobes and 5% sterile. Further, of the 99% culture positive cases, gram positive isolates were 22(31.42% and gram negative isolates were 48(68.57%. The isolated organisms were Pseudomonas aeruginosa (n=26; 37.15%, Staphylococcus aureus (n=15; 21.43%, Klebsiella pneumonia (n=12; 17.15%, Proteus spp. (n=6; 8.57%, Escherichia coli (n=4; 5.72%, Coagulase Negative Staphylococcus (n=5; 7.14%, Streptococcus pyogenes (n=1; 1%, Streptococcus pneumoniae (n=1; 1%, Bacteroides (n=13; 52%, peptostreptococcus (n=11; 44% and Fusobacterium (n=1; 4%. When antibiotic susceptibility was assessed, organisms were most susceptible to amikacin, followed by g the Antibiotics tested for sensitivity of the Isolates Amikacin stands first followed by Gentamicin and Ciprofloxacin. CONCLUSION CSOM is a serious condition, which is the most common cause of hearing loss, especially in the developing world. In our study, Pseudomonas aeruginosa was the most common causative organism, and amikacin seemed to be the most effective antibiotic with low resistance rates.

  4. Factors associated with group bullying and psychopathology in elementary school students using child-welfare facilities

    OpenAIRE

    Kim JW; Lee K; YS; Lee; Han DH; Min KJ; Song SH; Park GN; Lee JY; Kim JO

    2015-01-01

    Jun Won Kim,1,2 KounSeok Lee,3 Young Sik Lee,4 Doug Hyun Han,4 Kyung Joon Min,4 Sung Hwan Song,5 Ga Na Park,6 Ju Young Lee,1 Jae Ock Kim5 1Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, College of Medicine, Seoul National University, Seoul, South Korea; 2Department of Psychiatry, Graduate School, Chung-Ang University, Seoul, South Korea; 3Department of Psychiatry, Samsung Medical Center, Seoul, South Korea; 4Department of Psychiatry, Chung-Ang University, College...

  5. Korean Affairs Report.

    Science.gov (United States)

    2007-11-02

    93 Kim Chaek Iron Workers Discuss Kim Il-song Teachings (KCNA, 3 Jun 85) 95 Daily Marks Children’s Union Founding Day (KCNA, 6 Jun 85) 96...to traitor Chon Tu-hwan. At the same time, it was none other than the U.S. imperialists who ordered the attack on peaceful residents with iron fists...reunification of Korea, it notes. It demands the South Korean National Assembly to send a positive reply regarding this Tonsil to the DPRK Supreme

  6. A Level-headed Interpretation of Northeast Asia's New Developments

    Institute of Scientific and Technical Information of China (English)

    Wu Zhicheng

    2012-01-01

    The year 2011 kept the world very busy with one crisis after another. At the end of the year, North Korean leader Kim Jong-il passed away,focusing the world's attention on the problematic Korean Peninsula. North Korea is located at a strategic point in Northeast Asia and it has very complex political, economic and social problems. Where is North Korea heading under the new leader Kim Jong-un? It's an important question because it has bearing not only on the security and stability of Northeast Asia but also, perhaps, the whole Asia-Pacific region.

  7. Effects of BmKIM on sodium current of isolated cardiomyocytes, transmembrane action potential and aconitine induced arrhythmia in vivo in rabbits%东亚钳蝎毒素多肽对家兔心室肌细胞钠电流和在体动作电位的影响以及抗心律失常作用研究

    Institute of Scientific and Technical Information of China (English)

    王腾; 黄从新; 江洪; 唐其柱; 杨波; 李庚山

    2009-01-01

    目的 探讨基因表达得到重组的东亚钳蝎毒素多肽(BmKXM)对家兔单个心室肌细胞钠电流(INa)和在体动作电位的影响,以及对抗乌头碱诱发的心律失常电活动的作用.方法 用酶解法分离家兔心室肌细胞,全细胞膜片钳技术记录所需INa.采用浮置式玻璃微电极记录在体心肌细胞跨膜动作电位,并监测体表心电图.结果 (1)BmKIM 能明显抑制心肌细胞INa,使INa的电流-电压(I-V)曲线显著上移,但I-V曲线的形态没有发生改变.BmKIM使失活曲线显著左移,50%的INa失活电压分别由用药前的(-70.8±2.6)mV变为(-84.84±3.5)mV(P<0.05).在BmKIM作用下,心肌细胞INa失活后恢复时间明显延长,用药前快、慢恢复时间常数(Tf和Ts)分别是(28.9±6.1)ms和(107±21.6)me,给予BmKIM后,τf和τs分别是(54.2±7.9)ms(P<0.05)和(211.1±34.6)ms(P<0.01).(2)BmKIM 能明显改变记录在体心肌细胞跨膜动作电位时程(APD)和幅度(APA)以及最大上升速率(Vmax),使APD50和APD90都明显缩短,APA和Vmax显著减小.心电图上表现为QT间期缩短,心率明显加快.(3)乌头碱能明显触发后除极,诱发室件心动过速(室速),动作电位上表现为早期后除极和(或)延迟后除极.相对心电图上表现为插入性室性早搏或尖端扭转型室速(发生率为77.8%).BmKIM能明显降低乌头碱诱发的心律失常发生率(22.2%,P<0.01),更不能触发室速.结论 BmKIM对兔的心室肌细胞,INa有明显的抑制作用,这种抑制作用是通过与失活态的钠通道结合而发挥生理学效应,BmKIM 可抑制形成动作电位的钠离子内流,对抗乌头碱所致的心律失常发生,为开发具有选择性直接针对钠通道的阻滞剂BmKIM的应用前景打下基础.%Objective To investigate the effects of recombinant BmKIM (poly-peptide derived from Asian Scorpion Buthus martensi Karsch) on the sodium current (INa) of isolated ventricular myocytes,transmembrane action potential and aconitine induced

  8. 丁宁对阵韩国削球选手金景娥的技战术效果研究%Study on Technical and Tactical Effect of DING Ning While Fighting with KIM Kyungah

    Institute of Scientific and Technical Information of China (English)

    郭德兵

    2012-01-01

    运用文献资料法、数理统计法、专家访谈法、录像观察法、乒乓球技战术三段指标评估等方法,对我国优秀乒乓球运动员丁宁对阵韩国削球选手金景娥的比赛录像视频进行了技战术效果的统计分析。结果显示:丁宁在发球抢和接发球抢攻段中技战术运用效果欠佳,主要表现在三、五板和二、四板球的衔接不够流畅;在相持段中整体的技战术运用的较为灵活、多样,并取得了良好的效果,但在处理对搓的过渡球及多回合的相持球上耐心和信心都有待提高。%By using the method of literature review, mathematical statistics, expert interview, video observation and the table tennis three sections of index evaluation, this paper studies the Chinese excellent table tennis player DING Ning's technical and tactical effect of chopping technique when against Kim Kyungah. The result shows that DING Ning' s spiral, placement and the treatment of neutral ball in serves snatches and receive -attack seg- ment are unconscionable. The changes of DING Ning' s loops ( spin speed ) in rally part gain control over the game and the effect is good. However, the psychological compressive capacity needs to be improved.

  9. Urinary tubular protein-based biomarkers in the rodent model of cisplatin nephrotoxicity: a comparative analysis of serum creatinine, renal histology, and urinary KIM-1, NGAL, and NAG in the initiation, maintenance, and recovery phases of acute kidney injury.

    Science.gov (United States)

    Sinha, Vikash; Vence, Luis M; Salahudeen, Abdulla K

    2013-03-01

    Several biomarkers are becoming available for the early detection of acute kidney injury (AKI), but few have been directly compared. To compare urinary kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and N-acetyl glucosaminidase (NAG) against serum creatinine and renal histological score in the initiation, maintenance, and recovery phases of cisplatin (CP)-induced AKI. Sprague-Dawley rats (300-350 g) were injected once through their tail veins with CP (CP group) at 5.5 mg/kg or with same volume of normal saline vehicle (Control group). Rats were euthanized at 2, 4, 6, 12, and 24 hours, and on days 2, 3, 6, and 10 (n = 12 in the CP group and n = 6 in the Control group at each time point), and urine, blood, and kidney samples were analyzed. A significant increase in serum creatinine was noted by day 3 in the CP group versus Control group [1.46 (0.12) vs 0.28 (0.03) mg/dL; mean (SE); P CP group. Urinary kidney injury molecule-1 levels were significantly higher at 24 hours in the CP group than in the Control group [48.26 (13.13) vs 8.21 (3.31) pg/mg creatinine; P CP than in the Control group [NAG, 8.19 (0.82) vs 3.48 (0.40) pg/mg creatinine, P G 0.05; NGAL, 2911.80 (368.10) vs 1412.60 (250.20) pg/mg creatinine, P CP to discern the time course and pattern of expression.

  10. Comment on ''Fabrication methods for low-Pt-loading electrocatalysts in proton exchange membrane fuel cell systems'' [J.-H. Wee, K.-Y. Lee, S.H. Kim, J. Power Sources 165 (2007) 667-677

    Energy Technology Data Exchange (ETDEWEB)

    Gruber, D. [Department of Micro Systems Technology, Hamburg University of Technology, D-21071 Hamburg (Germany)

    2007-11-08

    Glow discharge sputter deposition of metals like Pt or other materials is around for decades. One of the many advantages of this process is - certain prerequisites given - the good adhesion of the sputtered layers due to the physical assisted deposition. Sputter deposition is attributed poor adherence by Wee et al. [Jung-Ho Wee, Kwan-Young Lee, Sung Hyun Kim, J. Power Sources 165 (2007) 667-677], which asks for some comments. (author)

  11. Fatma Barbarosoğlu’nun Hikâyelerine Yansıyan Kadın Kimliği The Women Identity Which Is Reflected In The Stories Of Fatma Barbarosoğlu

    Directory of Open Access Journals (Sweden)

    Alpay Doğan YILDIZ

    2012-12-01

    Full Text Available Fatma Barbarosoğlu has a different personality with writer herself. She has sociologist, storyteller, novelist, essayist, andcolumnist in newspaperwithwriterherself. Her sociologist personality’s firstbook is a Moda ve Zihniyet. She published this book in 1995. Shewroteanotherbookwith her personality. Her second book’s the Acı ve Deniz is a storybook and published in 1996. Mrs. Barbarosoğlupublished Acı Deniz with her 5 book inside of 10 years: Acı Deniz (1996, Gün Akşamsızdır (2000, Senin Hikâyen (2001, Ahir Zaman Gülüşleri (2002, İki Kişilik Rüyalar (2005. Shetakecognizanceofessay during these years.Fatma Barbarosoğlupublished 4essaybookmore of withintheseyear. Shebegansowrite a novelafter 2005.Aftershewrote of firstbook is Hiçbiryer her threenovelbecomefamous…Fatma Barbarosoğlu is one of theconsiderableauthors ofTurkishshortstoryafter 1990. Theauthorpublishedfiveshortstorybooksbetween the years 1996 and 2005. Thecharacters of FatmaBarbarosoğluliveduringtheyearstheshortstoriesarewritten, inotherwords, mostly in post-1990 period of Turkey.Thetopicslikepeople’sneed of narrating, lack of communication, lostmoral values, imagecentered life perception, author-reader-societyrelationship arediscussed. However, one of themostnotableissue is“woman”. Fatma Barbarosoğluconsidersthewoman inthesocietywithvariouskinds of identitieslikewife, mother,workingwoman, friendandstudent. Inthisarticle, thewomanidentities intheshortstories of theauthorwill be consideredcomprehensively. Fatma Barbarosoğlu, yazar olarak değişik kimliklere sahiptir. 0; sosyolog, hikâyeci, romancı, deneme yazarı, gazetede köşe yazarı… kimliklerine sahiptir. 1995’te yayımladığı ilk kitabı Moda ve Zihniyet sosyolog kimliğinin ürünüdür. Bu kimlikle başka kitaplar da yazmıştır. Yazarın ikinci eseri olan Acı Deniz bir hikâye kitabıdır ve 1996 yılında yayımlanır. Barbarosoğlu, sonraki yaklaşık on yıllık sürede Ac

  12. Семья Ким сохранит власть в КНДР / Юрген Тамме

    Index Scriptorium Estoniae

    Тамме, Юрген

    2011-01-01

    Põhja-Korea võimukorralduses toimuvat ümbritseb salapära. Kim jong-uni nooruse ja kogenematuse tõttu arvatakse, et lähiaastail juhib Põhja- Koread nõunikkond, kes aitab Kimil end eliidi seas kehtestada. Võimuvõitlus Põhja-Koreas

  13. Kimid hoiavad diktaatoritooli / Jürgen Tamme

    Index Scriptorium Estoniae

    Tamme, Jürgen

    2011-01-01

    Põhja-Korea võimukorralduses toimuvat ümbritseb salapära. Kim jong-uni nooruse ja kogenematuse tõttu arvatakse, et lähiaastail juhib Põhja- Koread nõunikkond, kes aitab Kimil end eliidi seas kehtestada. Võimuvõitlus Põhja-Koreas

  14. Airman Scholar Journal. Volume 19, Spring 2013

    Science.gov (United States)

    2013-01-01

    We Know Memes ” <http:// weknowmemes.com/2012/12/latest- north-korean-rocket-launch/>. 34. “North Korea Memes : Kim Jong Un Ballistic Rockets”<http...memeblender.com/tag/north-korea- memes />. 35. Strategy for Peace Conference 1998 : Warrenton, Va., Stanley Founda- tion, “Emerging from Conflict

  15. North Korea, Nuclear Weapons, and No Good Options?

    DEFF Research Database (Denmark)

    Cohen, Michael David

    2013-01-01

    How would Pyongyang’s development of the capability to target the United States with nuclear weapons influence North Korea’s foreign policy? I argue that it would cause more dangerous crises than those of the last decade, and predict that these crises would eventually cause Kim Jong Un and his se...

  16. The Care and Feeding of Warlords

    Science.gov (United States)

    2009-11-04

    take brides from the Uzbek and Tajik villages, deepening relations which continue to today through an inter-village council in the region.28 In...waters through the capture of international ships. In 2009, instability in Mexico , the ill-health of Kim Jong Il in North Korea, and separatist

  17. Kahe Korea liidrid võtsid vahelduseks jälle rahukursi / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2007-01-01

    Kohtusid Põhja- ja Lõuna-Korea juhid Kim Jong-il ja Roh Moo-hyun. Vastuvõetud deklaratsioonis ei puudutata tuumarelvaküsimust ega käsitleta sõjavange, kes jäid Põhja-Korea surmalaagritesse. Lisa: Lubadusi antakse ohtralt, täitma neid ei kiirustata

  18. В Южной Корее вновь пишут о болезни Ким Чен Ира / Эвелин Калдоя

    Index Scriptorium Estoniae

    Калдоя, Эвелин, 1980-

    2009-01-01

    Viidates Lõuna-Korea ja Hiina luureandmetele, väidab Lõuna-Korea meedia, et Põhja-Korea liidril Kim Jong-ilil on kõhunäärmevähk ja talle pole antud elada rohkem kui 5 aastat. Põhja-Korea valitsejadünastia

  19. Lõunakorealased pagesid taas varjendisse

    Index Scriptorium Estoniae

    2010-01-01

    Lõuna- ja Põhja-Korea pingestuvatest suhetest. Lõuna-Korea kaitseministeerium kutsus rünnaku alla sattunud Yeonpyeongi saarel viibivaid ajakirjanikke sealt lahkuma, USA staabiülemate ühendkomitee juht admiral Mike Mulleni hinnangul ei ole Põhja-Korea liider Kim Jong-Il kontrollitav

  20. Семья Ким сохранит власть в КНДР / Юрген Тамме

    Index Scriptorium Estoniae

    Тамме, Юрген

    2011-01-01

    Põhja-Korea võimukorralduses toimuvat ümbritseb salapära. Kim jong-uni nooruse ja kogenematuse tõttu arvatakse, et lähiaastail juhib Põhja- Koread nõunikkond, kes aitab Kimil end eliidi seas kehtestada. Võimuvõitlus Põhja-Koreas

  1. Regional Overview: Continuity Prevails for Better and for Worse

    National Research Council Canada - National Science Library

    Ralph A Cossa; Brad Glosserman

    2013-01-01

    ... on the Kim Jong Un regime than it was when his father ruled to roost. Meanwhile, new Secretary of State John Kerry made his first visit to Asia to underscore the second Obama administration's - and his own personal - commitment to America's rebalance to Asia. His major policy address while in Japan also tried to underscore a consistent - if still not w...

  2. Kimid hoiavad diktaatoritooli / Jürgen Tamme

    Index Scriptorium Estoniae

    Tamme, Jürgen

    2011-01-01

    Põhja-Korea võimukorralduses toimuvat ümbritseb salapära. Kim jong-uni nooruse ja kogenematuse tõttu arvatakse, et lähiaastail juhib Põhja- Koread nõunikkond, kes aitab Kimil end eliidi seas kehtestada. Võimuvõitlus Põhja-Koreas

  3. Usmirenije Severnoi Korei / Joseph S. Nye ; tõlk. Nikolai Zhdanovitsh

    Index Scriptorium Estoniae

    Nye, Joseph S.

    2006-01-01

    USA president George Bush lootis, et tal õnnestub Põhja-Korea tuumaprobleemi lahendada režiimi vahetamisega. Arvestati, et isolatsioon ja sanktsioonid viivad Kim Jong Il'i diktatuuri kukutamiseni. Kuna režiim osutus vastupidavaks, nõustuti kuuepoolsete läbirääkimistega Hiina, Venemaa, Jaapani ja mõlema Koreaga

  4. Usmirenije Severnoi Korei / Joseph S. Nye ; tõlk. Nikolai Zhdanovitsh

    Index Scriptorium Estoniae

    Nye, Joseph S.

    2006-01-01

    USA president George Bush lootis, et tal õnnestub Põhja-Korea tuumaprobleemi lahendada režiimi vahetamisega. Arvestati, et isolatsioon ja sanktsioonid viivad Kim Jong Il'i diktatuuri kukutamiseni. Kuna režiim osutus vastupidavaks, nõustuti kuuepoolsete läbirääkimistega Hiina, Venemaa, Jaapani ja mõlema Koreaga

  5. Planning for Stability

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Chinese and North Korean leaders agree to move forward together C hina and the Democratic People’s Republic of Korea(DPRK) should enhance cooperation on various fronts,while maintaining close coordination on issues in the region,Chinese President Hu Jintao said during a meeting with visiting DPRK top leader Kim Jong Il on August 27.

  6. Planning for Stability

    Institute of Scientific and Technical Information of China (English)

    DING YING

    2010-01-01

    @@ China and the Democratic People's Republic of Korea (DPRK) should enhance cooperation on various fronts, while maintaining close coor-dination on issues in the region, Chinese President Hu Jintao said during a meeting with visiting DPRK top leader Kim Jong Ⅱ on August 27.

  7. Prospective Study of Lipoprotein(a) as a Risk Factor for Deteriorating Renal Function in Type 2 Diabetic Patients With Overt Proteinuria

    National Research Council Canada - National Science Library

    Ki-Ho Song; Seung Hyun Ko; Hyung-Wook Kim; Yu-Bae Ahn; Jong-Min Lee; Hyun-Shik Son; Kun-Ho Yoon; Bong-Yun Cha; Kwang-Woo Lee; Ho-Young Son

    2005-01-01

    Prospective Study of Lipoprotein(a) as a Risk Factor for Deteriorating Renal Function in Type 2 Diabetic Patients With Overt Proteinuria Ki-Ho Song , MD , Seung Hyun Ko , MD , Hyung-Wook Kim , MD , Yu-Bae Ahn , MD , Jong-Min Lee , MD...

  8. Kahe Korea liidrid võtsid vahelduseks jälle rahukursi / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2007-01-01

    Kohtusid Põhja- ja Lõuna-Korea juhid Kim Jong-il ja Roh Moo-hyun. Vastuvõetud deklaratsioonis ei puudutata tuumarelvaküsimust ega käsitleta sõjavange, kes jäid Põhja-Korea surmalaagritesse. Lisa: Lubadusi antakse ohtralt, täitma neid ei kiirustata

  9. В Южной Корее вновь пишут о болезни Ким Чен Ира / Эвелин Калдоя

    Index Scriptorium Estoniae

    Калдоя, Эвелин, 1980-

    2009-01-01

    Viidates Lõuna-Korea ja Hiina luureandmetele, väidab Lõuna-Korea meedia, et Põhja-Korea liidril Kim Jong-ilil on kõhunäärmevähk ja talle pole antud elada rohkem kui 5 aastat. Põhja-Korea valitsejadünastia

  10. North Korean Policy Elites

    Science.gov (United States)

    2004-06-01

    credibility, and mass appeal, and become fluid, porous, malleable, and transient. Incumbent gods and demi-gods enter the twilight zone as the rising...Fairclough, Gordon, “Pyongyang Place: The Family Saga of Kim Jong Il,” The Wall Street Journal, p. A1, October 10, 2003; “Japanese Weekly Examines

  11. L’enfant et l’Empire. Poétiques de l’Inde coloniale dans Kim de Kipling (1901 et Swami and friends de R.K. Narayan (1935, ou la littérature par l’enfance

    Directory of Open Access Journals (Sweden)

    Claudine Le Blanc

    2012-01-01

    Full Text Available Si l’enfant dans la littérature coloniale vient en général servir l’orientation idéologique de celle-ci, il peut aussi subtilement la perturber, comme en témoigne le célèbre roman de Kipling, Kim (1901 mais aussi bien une œuvre de la littérature indo-anglaise qui évoque la lutte pour l’Indépendance : Swami and Friends (1935 de R. K. Narayan. Dans l’un et l’autre roman, l’enfant vient saper le dispositif idéologique et assure le triomphe d’une littérature non pas tant pour l’enfance que par l’enfance : l’Inde dans Kim apparaît comme une spatialisation enchantée du temps de l’enfance d’où l’univers du colonat, très présent dans les Plain Tales of the Hills, s’évanouit, tandis que le protagoniste enfantin de Swami and Friends permet à R.K. Narayan de développer l’écriture distanciée, tout en ironie et suggestion, qui deviendra son style.

  12. The value of urinary KIM-1,serum cystatin C in predicting the early diabetic nephropathy%尿肾损伤分子-1与血胱蛋白酶抑制剂 C对早期糖尿病肾病诊断价值对比研究

    Institute of Scientific and Technical Information of China (English)

    袁朝伟; 杨茂君; 周雪琴; 黄炜; 徐勇

    2013-01-01

    Objective To measure the levels of urinary KIM-1 and serum cystatin C in type 2 diabetic patients(DM) with different degree of albuminuria and to evaluate the value of these biomarkers in predicting the early diabetic nephropathy ( DN) .Methods One hundred and eighteen subjects with type 2 diabetes mellitus and 41 control subjects were recruited;In the diabetic patients ,44 were normoalbuminuric ,41 were microalbuminuric ,and 33 were macroalbuminuric ,according to their urine albumin/creatinine ratio ( UACR) .Collecting fresh morning urine and plasma samples to detect the levels of KIM-1 and Cystatin C .Results The levels of urinary KIM-1 ( UKIM-1 ) were significantly higher in the DM group than in the control group ,but no significantly difference between DM groups .The levels of serum cystatin C were significantly higher in the DM group than in the control group , which increased corresponding with UACR .UKIM-1 and serum Cystatin C were positively related with UACR ( r=0.427 ,0.726 ,both P<0.001 ) and negatively related with eGFR ( improved simplified MDRD formula ) ( r =-0.008 , -0.791 , for Cystatin C P<0.05 ) .Conclusion Our study indicates that UKIM-1 may be useful to assess early kidney injury prior to microalbuminuria ,and serum Cystatin C can predict the severity of all stages of DN .%目的本研究主要探讨尿肾损伤分子-1(KIM-1)及血胱蛋白酶抑制剂C(Cystatin C)对早期糖尿病肾病的诊断价值及糖尿病肾病发展的预测价值。方法选取我院内分泌科住院2型糖尿病患者118例,依据尿微量白蛋白/肌酐比值( UACR)将糖尿病患者分为糖尿病对照组、糖尿病微量白蛋白尿组以及糖尿病大量蛋白尿组,同期健康体检者41例作为正常对照组。收集各组清晨清洁中段尿,应用酶联免疫吸附法检测各组中尿KIM-1浓度。血清中Cystatin C浓度采用乳胶增强免疫比浊法进行检测。结果尿KIM-1在糖尿病各组中浓度

  13. Guiding role of KIM-1 in the using of different types of diuretics in patients with cardiorenal syndrome%KIM-1在心肾综合征不同利尿剂合用中的指导价值

    Institute of Scientific and Technical Information of China (English)

    陈春莲; 李志樑; 傅强

    2016-01-01

    目的:探讨肾脏损伤分子1(KIM-1)在指导心肾综合征患者袢利尿剂与噻嗪类利尿剂合用是否有利于增强利尿效果和保护肾功能。方法将75例心肾综合征患者随机分为两组,对照组35例依据体重+NYHA 心功能分级进行用药,实验组40例依据尿液KIM-1水平指导用药,测量连续最低药量维持1个月后血清肌酐、胱抑素C和中性粒细胞明胶酶相关脂质运载蛋白(NGAL)和尿液KIM-1的变化,并比较两组并发症发生率。结果使用利尿剂前至开始使用最低药量维持时,两组血清肌酐、胱抑素C、NGAL和尿液KIM-1水平均有所下降,其中实验组上述指标下降程度尤为明显,与对照组比较差异有统计学意义(P<0.05),连续最低药量维持1个月后,指导组血清肌酐、胱抑素C、NGAL和尿液KIM-1均明显下降,且均明显低于对照组,差异有统计学意义(P<0.05);实验组低血钾和脱水发生率低于对照组,但差异无统计学意义(P>0.05)。结论根据KIM-1水平调整袢利尿剂与噻嗪类利尿剂合用剂量有利于增强心肾综合征患者的利尿效果,更有利于患者肾功能的保护。%Objective To explore the guiding role of kidney injury molecule 1 (KIM-1) for using of loop diuretics combined with thiazide diuretics in patients with cardiorenal syndrome, and evaluate the diuretic and renal protection effects. Methods 75 cases of cardiorenal syndrome patients in our hospital were randomly divided into two groups;the treatment for the control group was based on the weight + NYHA heart function classification to guide medication; treatment for experimental group was based on the urine KIM-1 level to guide medication.Serum creatinine,cystatin C, NGAL and KIM-1 levels in two groups after using the lowestdose and retained for 1 month were compared, and the complications were also compared too. Results The serum creatinine

  14. Modulation of Acetylation: Creating a Pro-survival and Anti-Inflammatory Phenotype in Lethal Hemorrhagic and Septic Shock

    Science.gov (United States)

    2011-01-01

    no. 1-2, pp. 73–76, 1999. [84] H. S. Park , S. G. Cho, C. K. Kim et al., “Heat shock protein Hsp72 is a negative regulator of apoptosis signal...1, pp. 474–481, 2010. [98] A. R. Kochenek, E. Y. Fukudome, J. S. Eleanor et al., “Phar- macological resuscitation attenuates MAP kinase pathway...inhibitors,” Journal of Neurochemistry, vol. 87, no. 2, pp. 407–416, 2003. [131] Y. Choi, S. K. Park , M. K. Hwan et al., “Histone deacetylase inhibitor

  15. Reference: 710 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 710 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18162593i Jung Choonkyun et al. 2008 Fe...ic stress tolerance of transgenic Arabidopsis overexpressing AtMYB44 was conferred by reduced expression of ...naling. Overexpression of AtMYB44 enhances stomatal closure to confer abiotic stress tolerance in transgenic... Arabidopsis. 2 623-35 18162593 2008 Feb Plant physiology Cheong Jong-Joo|Choi Yang Do|Han Sang Won|Jung Choonkyun|Kim Chung Ho|Koo Yeon Jong|Nahm Baek Hie|Seo Jun Sung|Song Sang Ik

  16. Jonge vrouwen werken aan hun toekomst. De invloed van de kwaliteit van de arbeid op de loopbaanontwikkeling van laaggeschoolde jonge vrouwen

    NARCIS (Netherlands)

    Jorna, Anna Elisabeth; Offers, Ellen Harriët

    1994-01-01

    Since the 1960s, the traditional division of labour between the sexes had started to change. The male role of breadwinner and the female role of mother and housewife were no longer taken for granted and both women and men became more options to shape their own lives. In the same period the rise of t

  17. 民族叙事与女性话语——越南阮攸的创作及《金云翘传》的经典%National Narration and Women's Discourse-Nguyen Du and His Classic of Tyuen Kim Vien Kieu

    Institute of Scientific and Technical Information of China (English)

    黄玲

    2011-01-01

    《金云翘传》作为越南民族的文学经典,是诗人阮攸对中国青心才人所著同名章回小说的移植和改创。在《金云翘传》中,凝结了作家主体精神对越南民族的文化传统与历史命运的思考与探求,整个叙事是民族叙事与女性话语的有机融合。翠翘形象是越南民族母道信仰和女神原型的再现,蕴藉着牺牲与救赎的深度模式。《金云翘传》的经典化及其在民间社会广为传播,使得这一作品已经内化为越南民族的审美意识,彰显出越南文学民族化的独特轨迹。%As a literary classic of the Vietnamese nation,Tyuen Kim Vien Kieu,created by Nguyen Du,was a duplicate of the namesake novel by Qingxin Cairen in the Qing Dynasty.Tyuen Kim Vien Kieu epitomizes the author's subjectivity in his reflections upon the cultural traditions of the Vietnamese nation and historical fate,and integrates national narration and women's discourse in an organic way.The image of Cuiqiao turned out to be a representation of the nation's love for Mother and the prototype of the country's goddess,demonstrating the nation's pattern of sacrifice and redemption in an in-depth way.The canonization,popularization and dissemination of the work in civil society have rendered itself internalized into the national aesthetic tradition of the Vietnamese,revealing the unique way of the nationalization of the Vietnamese literature.

  18. Belarus - a unique case in the European context? / Kim Lausten

    Index Scriptorium Estoniae

    Lausten, Kim

    2003-01-01

    Valgevene presidendi Aleksander Lukashenko autoritaarsest režiimist, sellega seonduvatest võimalikest ohtudest Valgevene naaberriikide julgeolekule. Autor analüüsib Lukashenko režiimi institutsioonilisi ning sotsiaalpoliitilisi tagamaid

  19. [Recent books on international law] / Yoonie Kim, Paul R Williams

    Index Scriptorium Estoniae

    Kim, Yoonie

    2005-01-01

    Arvustus: Lauri Mälksoo. Illegal Annexation and State Continuity : The Case of the Incorporation of the Baltic States by the USSR. Study of the Tension between Normativity and Power in International Law. Leiden ; Boston, 2003

  20. INCIDENCE AND CLINICAL FEATURES OF SNAKEBITE CELLULITIS AT KIMS, HUBLI

    Directory of Open Access Journals (Sweden)

    Chetan

    2014-12-01

    Full Text Available BACKGROUND: A single centre study was planned to asses the incidence and clinical feature of snake bite cellulitis in order to find out the nature and burden of the disease. OBJECTIVES: To assess incidence and clinical features of snake bite cellulitis. METHODOLOGY: This present one year prospective study was conducted in the Department of Surgery, Karnataka Institute of Medical Sciences, Hubli. Out of 520 total cases of snake bites 66 patients with cellulitis changes were studied. STATISTICAL ANALYSIS: The data obtained was coded and entered in Microsoft Excel Spreadsheet. The categorical data was expressed as rates, ratios and percentages. RESULTS: Out of 520 total snake bite cases, 66 patients developed signs of cellulitis. In patients with cellulitis 49(74.24% were males and 17(25.75% were females. In patients with cellulitis, most were aged between 31 to 45 years (36.36% and 19 to 30 years (34.84.The mean age of the study population was 32.43 ± 13.75 years. Majority of the patients (74.24% had snake bite on lower limbs. Most common symptom complex noted was pain + swelling in 30(39.39% of the patients followed by pain in 9(13.6%, swelling in 6(9%, pain+swelling+fever in 4(6%, pain + discolouration in 2(3% and pain + fever in 1(1.5% of the patients. CONCLUSIONS: The present study shows high incidence of cellulitis in patients with snake bite and most common clinical feature is cellulitis is pain + swelling. So in any case of snake of snake bite we should take the proper precautionary measures to prevent cellulitis. If cellulitis has already formed, then it should be treated without delay in order to prevent limb loss, compartment syndrome, other morbidities and even death.

  1. [Recent books on international law] / Yoonie Kim, Paul R Williams

    Index Scriptorium Estoniae

    Kim, Yoonie

    2005-01-01

    Arvustus: Lauri Mälksoo. Illegal Annexation and State Continuity : The Case of the Incorporation of the Baltic States by the USSR. Study of the Tension between Normativity and Power in International Law. Leiden ; Boston, 2003

  2. Seši u Plitvičkim jezerima

    OpenAIRE

    Pasarić, Miroslava; Slaviček, Lasta

    2016-01-01

    Poduzeta su visokofrekventna mjerenja razine vode u dva najveća plitvička jezera, u Prošću i u Kozjaku, kako bi se istražili seši. Mjerenja su rađena s intervalom uzorkovanja od 1 minute tijekom perioda od 46 dana i to na dva suprotna kraja u svakom jezeru, što je dalo informaciju i o međusobnom odnosu faza. Izračunati su spektri snage kako bi se odredili periodi vlastitih modova. Opaženi maksimimi su interpretirani uz pomoć teorijskih rezultata, dobivenih jednostavnom numeričkom metodom Defa...

  3. Application of Hosaka and DJ Kim Whatmann paper protocols for ...

    African Journals Online (AJOL)

    PRECIOUS

    2009-12-01

    Dec 1, 2009 ... selection (MAS) for breeding for striga resistance in cowpea to be able to handle large number of ... The application of marker assisted selection in cowpea .... extraction of DNA from tomato and other herbaceous plants. Plant.

  4. Social-Economic Foundation for Smooth Changes in Korea

    Institute of Scientific and Technical Information of China (English)

    Wang Zaibang

    2012-01-01

    Chairman Kim Jong-il's death has sparked worldwide interest in the 'future direction of the D.P.R.K. political, economic, social and diplomatic policies. After all, as the youngest national leader in the world, Kim Jong-un has little experience, especially as he has been involved in national governance for such a very short time. Whether he earl unite all the high-level leaders of the ruling party, government and military and achieve a smooth transition in national political, economic and social life will affect the well-being of all Korean people, and the security and stability in the whole of Northeast Asia. However, a dispassionate analysis of North Korea's recent economic and social development may show that North Korea's future prospects may not be as gloomy as some people predict.

  5. Predictie van groei vanaf jonge leeftijd: ‘curve matching’ met de TNO groeivoorspeller

    NARCIS (Netherlands)

    van Buuren, Stef; Bezemer, RA; Reijneveld, Sijmen; L'Hoir, MP

    2015-01-01

    Curve matching is a new big data technique to predict an outcome given earlier measurements. Here we apply curve matching to predict the future growth of a specific child, the target child. The method searches in large datasets of longitudinal growth data for other children who are similar to the ta

  6. Zoeken naar zuiverheid. Religieuze purificatie onder jonge new-agers, evangelicalen en moslims

    NARCIS (Netherlands)

    Koning, M.J.M. de; Roeland, J.; Aupers, S.; Houtman, D.; Noomen, I.

    2010-01-01

    This article addresses New Age spirituality, evangelicalism and Salafism, three vital forms of religion among contemporary Dutch youth. Despite the obvious differences between these religions there is a crucial similarity: it is demonstrated that young people adhering to these groups formulate stron

  7. Motieven voor jonge autobestuurders om de autogordels niet (altijd) te gebruiken : een belevingsstudie.

    NARCIS (Netherlands)

    Wittink, R.D.

    1993-01-01

    A qualitative study has been conducted among a small group of young male motorists who do not always wear a seat belt. This study took place in the Dutch province of Gelderland and was commissioned by the regional board of Gelderland. The study provides a very clear picture of feelings, experiences,

  8. Asthma Symptoms in Early Childhood: A public health perspective [Astmasymptomen bij jonge kinderen: een volksgezondheids perspectief

    NARCIS (Netherlands)

    Hafkam-de Groen, E.

    2014-01-01

    This thesis focuses on asthma symptoms in early childhood. From a public health perspective, we aim to improve health and health-related quality of life through the prevention of asthma symptoms and by signaling, counselling or management of children who are at a high risk of developing asthma. The

  9. Overgewicht bij jonge kinderen en volwassenen: kwantificeren van de kloof tussen energie-inneming en energieverbruik

    NARCIS (Netherlands)

    Berg SW van den; Scholtens S; Wijga AH; Verschuren WMM; Boer JMA; CVG; PZO

    2006-01-01

    For the first time in the Netherlands the gap between energy intake and energy expenditure has been quantified for children and adults. Small daily changes in energy balance may, in the long term, make the difference between becoming overweight or not. Ten per cent of two-year olds either develop ov

  10. Expertmeeting `Fietshelmgebruik door jonge kinderen in Nederland', gehouden op 7 november 2002.

    NARCIS (Netherlands)

    Vriend, I. Hertog, P.C. den Stam, C. Goldenbeld, C. Schaalma, H. Volkstedt, I. & Eck, S. van

    2003-01-01

    This report gives an account of an expert meeting held in the Netherlands on 7th November 2002. The purpose of this meeting was to develop recommendations for activities aimed at promoting bicycle helmet use by children, and to achieve a very strong support for these recommendations. The expert meet

  11. Antenne 2010: trends in alcohol, tabak en drugs bij jonge Amsterdammers

    NARCIS (Netherlands)

    A. Benschop; T. Nabben; D.J. Korf

    2011-01-01

    Since 1993, Amsterdam Antenna has been documenting and analysing trends in nightlife and substance use among Amsterdam young adults and adolescents. Our panel study traces the latest developments every year by holding individual, semi-annual interviews with a panel of avid nightlifers and profession

  12. Zoeken naar zuiverheid. Religieuze purificatie onder jonge new-agers, evangelicalen en moslims

    NARCIS (Netherlands)

    Koning, M.J.M. de; Roeland, J.; Aupers, S.; Houtman, D.; Noomen, I.

    2010-01-01

    This article addresses New Age spirituality, evangelicalism and Salafism, three vital forms of religion among contemporary Dutch youth. Despite the obvious differences between these religions there is a crucial similarity: it is demonstrated that young people adhering to these groups formulate stron

  13. Overgewicht bij jonge kinderen en volwassenen: kwantificeren van de kloof tussen energie-inneming en energieverbruik

    NARCIS (Netherlands)

    Berg SW van den; Scholtens S; Wijga AH; Verschuren WMM; Boer JMA; CVG; PZO

    2006-01-01

    For the first time in the Netherlands the gap between energy intake and energy expenditure has been quantified for children and adults. Small daily changes in energy balance may, in the long term, make the difference between becoming overweight or not. Ten per cent of two-year olds either develop ov

  14. The Hughes Court and Radical Dissent: The Case of Dirk De Jonge and Angelo Herndon

    OpenAIRE

    Tushnet, Mark V.

    2012-01-01

    Scattered Supreme Court decisions in the early twentieth century dealt with the Constitution’s protection of freedom of speech. Radical dissent over United States participation in World War I and the nation’s intervention against the Bolshevik revolution in Russia led the Court to its first sustained engagement with free speech cases. By the time Chief Justice Hughes took the center chair, the national government largely had abandoned its pursuit of radical dissenters, some of whom played la...

  15. Making Democracy Safe for the World: A Game Theory Analysis of the Impact of Elites on the Democratization Process

    Science.gov (United States)

    2008-12-01

    p. 590). Social capital can serve as an antidote. It helps temper the spread of egoism , and upholds the protection of civil liberties. Most...demonstrates how elite behavior can show evidence of multiple desires. In this case , the unique blend of desires exhibited by Kim Jong Il...the group attempting to inaugurate democracy in the target nation. In recent cases , transitioners have not been native to the target nation

  16. North Korea -- Still an Intelligence Problem

    OpenAIRE

    2014-01-01

    A few years after Kim Jong Un came into office, North Korea is still attracting controversy in the headlines, and political sanctions are still in operation. Despite the harsh measures in place to isolate Pyongyang from sources of money and luxury, the rulers are able to get what they want using front companies or the help of other states. The reasons for this are deeply rooted in the North Korean political structure. A network of high ranking officials, their children, and political minions ...

  17. United States’ Engagement Strategy for North Korea

    Science.gov (United States)

    2007-06-01

    counter view supports economic engagement with North Korea, like South Korea’s now defunct “ Sunshine Policy.” Economic engagement strategies are...Korean territorial waters in August 2003. Both governments dismissed these incidents and continued on the sunshine path. In 2003, North Korea...as General Secretary of the Korean Workers Party. The post of President was eternal , but Kim Jong-il also became the Chairman of the National

  18. North Korea and Support to Terrorism: An Evolving History

    Directory of Open Access Journals (Sweden)

    Bruce E. Bechtol, Jr.

    2010-01-01

    Full Text Available The DPRK's (Democratic People's Republic of Korea or North Korea support for terrorism began as an ideologically-based policy financed by the Soviet Union that eventually led to a policy designed to put money into the coffers of the elite in Pyongyang—in short, a "proliferation for hire" policy. This article articulates a brief history of the North Korean regime, the rise to power of Kim Il-sung and his son, Kim Jong-il, and North Korea's persistent support to terrorist groups around the globe.

  19. Planning for a Peaceful Korea

    Science.gov (United States)

    2001-03-01

    Korea caused the “Cold War structure” in that part of East Asia. He says the United States must see to it that its “Cold War syndromes ” are ended...and his son Kim Jong Il) are Romanized in accordance with the McCune -Reischauer system, less diacritical marks. 2. The term “Kim family regime” is...Secretary of State Madeleine Albright , address to troops in Korea’s DMZ, February 22, 1997, as released by the Office of the State Department spokesman

  20. Samiha Ayverdi’nin “Batmayan Gün” Romanında Kadın Kimliği Üzerine Bir İnceleme A Research on Woman Identity in Samiha Ayverdi’s Novel “Unsunken Day”

    Directory of Open Access Journals (Sweden)

    Mustafa Sıddık KARAGÖZ

    2012-09-01

    ören Ayverdi, bu tutumundan hiçbir zaman vazgeçmemiştir. O, kadın romancılarda aşk rüzgârlarının popülerliğini koruduğu zamanlarda bile, bu rüzgârlara kapılmamış, memleket meselelerini, gençliğin, toplumun sorunlarını ve bunlarla ilgili yapılması gerekenleri ele alma farklılığını göstermiştir. Yazar, bütün bu meseleler için çıkış yolu ararken çoğu zaman, kadını çözümün merkezinde görmüştür. Milletin terakki edebilmesi için kadının yüklenmesi gereken vazifelerle ilgili, okuyucularına tavsiyelerde bulunan Samiha Ayverdi yeni nesli yetiştirecek olan kadının öncelikle manevi hayatının sağlamlaştırılmasının gerekliliğine dikkat çekmiştir. Ayverdi’de tasavvuf, onun hayatının her alanını kuşatacak kadar büyük yer teşkil eder. Ümm-i Ken’an Dergahının Şeyhi Kenan Rıfâî ile tanıştıktan sonra, hayatına Rıfailik’in öğretileri doğrultusunda yön veren Ayverdi’nin manevi dünyasındaki bu değişim eserlerine de yansımıştır. “Batmayan Gün”, onun tasavvuf anlayışını ortaya koyan ilk romanlarından olması bakımından önemlidir. Tasavvufun bir kadın kahramanın “arayış” serencamı üzerinden ele alınması ise eseri “kadın kimliği” bakımından incelemeyi değerli kılmaktadır. “Batmayan Gün”de kadın; “entelektüel, mutasavvıf, sade dümdüz, temiz, zavallı, gösteriş düşkünü” gibi tanımlamalarla okuyucu karşısına çıkarılmaktadır. Yazar, kadının söz konusu bu kimliklerinden özellikle “mutasavvıf kadın”ı öne çıkarmış, ona entelektüel nitelikler de yükleyerek, okuyucusuna bir bakıma bu kadın kimliğini benimsemesi telkininde bulunmuştur. Bu telkine, Cumhuriyet’in yeni neslinin yetiştirilmesi adına, Ayverdi tarafından Cumhuriyet rejimine sunulmuş önemli bir öneri olarak da bakılabilir.

  1. “Şimdi Ben Öğretmen mi Oldum?” Öğretmenlik Kimliğinin Oluşmasında Etkili Olan Etkenlere Yönelik Öğretmen Adaylarının Görüşleri “Have I Become A Teacher?” The Perspectives Of Preservice Teachers About Factors That Are Effective On The Formation Of The Teacher Identity

    Directory of Open Access Journals (Sweden)

    Mustafa YAŞAR

    2013-09-01

    Full Text Available The teacher identity is important in terms of determination of thetype of teaching that the teachers will use and their probable attitudestowards changes in the field of education. Therefore, in this study, itwas aimed to determine the factors which have roles in pre-schoolpreservice teachers’ formation of teacher identity and how preserviceteachers comment on these factors. This research is a qualitative study,carried out in the 2009-2010 academic year. The sample of the researchconsisted of 90 participants, 65 of which were senior students studyingat Çukurova University, Faculty of Education Pre-school TeachingDepartment and 25 of which were teachers who graduated from thesame department in 2009 and who just started teaching in Adana andin surrounding cities. The data was collected through the Survey ofDetermining the Factors which form the Teacher Identity (SDTI thatwas developed by the researchers. This survey consists of two parts.There were items about personal information in the first part and therewere items about the factors which are effective in the formation ofteacher identity in the second part. The levels of preservice teachers’agreeing with these items were designed in the five-point Likert scale (Icompletely agree=5, I don’t agree at all=1. The data was analyzed bydescriptive data analysis method, the answers which were given to theopen-ended questions were coded by content analysis and then, theywere categorized. The results of the research showed that the factorswhich are effective in the formation of teacher identity were personalitytraits, willingness to teach, the education which were received atuniversity, social environment and the teaching practice. Another resultof the research revealed that the preservice teachers feel themselves asteachers beginning from the third grade. Öğretmenlik kimliği, öğretmenlerin nasıl bir öğretim yapacağını ve eğitim alanındaki değişikliklere karşı ne tür tutumlar tak

  2. Gunstige invloed van een standaardeliminatiedieet op het gedrag van jonge kinderen met aandachtstekorthyperactiviteitsstoornis (ADHD), een verkennend onderzoek.

    NARCIS (Netherlands)

    Pelsser, L.M.J.

    2002-01-01

    OBJECTIVE: To determine whether a standard elimination diet can decrease the ADHD-symptoms in a heterogeneous group of young children with ADHD. DESIGN: Open, descriptive. METHOD: 40 children, 36 boys and 4 girls, aged 3-7 (average 4.8 years), who met the DSM-IV-criteria for ADHD, followed their usu

  3. Jonge brom- en snorfietsers: kan hun ongevalskans sterk omlaag? : effecten van maatregelen en draagvlak daarvoor onder jongeren en organisaties.

    NARCIS (Netherlands)

    Schoon, C.C. & Goldenbeld, C.

    2004-01-01

    In the report of late 2001 Safe, What is Safe?, SWOV indicated how the annual number of traffic casualties could be reduced considerably. These proposals were to be regarded as an addition to the proposals as were developed in the then National Traffic and Transport Plan of the Ministry of Transport

  4. De invloed van geïdealiseerde mediabeelden op het zelfbeeld van jonge meisjes: Het positieve effect van mediabewustzijn.

    NARCIS (Netherlands)

    Deen, van der F.S.; Schwinghammer, S.A.; Verkooijen, K.T.

    2011-01-01

    This study examines the influence of idealised (extremely attractive) models appearing in beauty advertisements on the self-image of 10-13 year-old girls and investigates the possible protective role of media awareness. Model attractiveness (idealised vs. normally attractive) and media awareness (in

  5. Ziet men een tegenstelling tussen jong en oud? Een studie naar de invloed van sociale identificatie, competitie en contact

    NARCIS (Netherlands)

    Pauw, Rodinde; Maas, Ineke

    2015-01-01

    In this study we ask to what extent the Dutch population perceives a conflict between the young and old and how we can explain this. We use Social Identification Theory, Realistic Conflict Theory, and Contact Theory to derive hypotheses. These are tested with newly collected data on a representative

  6. Written Corrective Feedback Studies: Approximate Replication of Bitchener & Knoch (2010a) and Van Beuningen, De Jong & Kuiken (2012)

    Science.gov (United States)

    Bitchener, John; Knoch, Ute

    2015-01-01

    The question of whether written corrective feedback (CF) has a role to play in second language (L2) development has been controversial since Truscott (1996) published an article in "Language Learning" calling for the abandonment of the practice on theoretical, empirical and pedagogical grounds. As a result of his claims, an on-going…

  7. VizieR Online Data Catalog: KiDS-ESO-DR2 multi-band source catalog (de Jong+, 2015)

    NARCIS (Netherlands)

    de Jong, J. T. A.; Verdoes Kleijn, G. A.; Boxhoorn, D. R.; Buddelmeijer, H.; Capaccioli, M.; Getman, F.; Grado, A.; Helmich, E.; Huang, Z.; Irisarri, N.; Kuijken, K.; La Barbera, F.; McFarland, J. P.; Napolitano, N. R.; Radovich, M.; Sikkema, G.; Valentijn, E. A.; Begeman, K. G.; Brescia, M.; Cavuoti, S.; Choi, A.; Cordes, O.-M.; Covone, G.; Dall'Ora, M.; Hildebrandt, H.; Longo, G.; Nakajima, R.; Paolillo, M.; Puddu, E.; Rifatto, A.; Tortora, C.; van Uitert, E.; Buddendiek, A.; Harnois-Deraps, J.; Erben, T.; Eriksen, M. B.; Heymans, C.; Hoekstra, H.; Joachimi, B.; Kitching, T. D.; Klaes, D.; Koopmans, L. V. E.; Koehlinger, F.; Roy, N.; Sifon, C.; Schneider, P.; Sutherland, W. J.; Viola, M.; Vriend, W.-J.

    2017-01-01

    KiDS data releases consist of ~1 square degree tiles that have been successfully observed in all four survey filters (u,g,r,i). The second data release (KiDS-ESO-DR2) was available in February 2015 and contains imaging data, masks and single-band source lists for all tiles observed in all four

  8. VizieR Online Data Catalog: KiDS-ESO-DR3 multi-band source catalog (de Jong+, 2017)

    NARCIS (Netherlands)

    de Jong, J. T. A.; Verdoes Kleijn, G. A.; Erben, T.; Hildebrandt, H.; Kuijken, K.; Sikkema, G.; Brescia, M.; Bilicki, M.; Napolitano, N. R.; Amaro, V.; Begeman, K. G.; Boxhoorn, D. R.; Buddelmeijer, H.; Cavuoti, S.; Getman, F.; Grado, A.; Helmich, E.; Huang, Z.; Irisarri, N.; La Barbera, F.; Longo, G.; McFarland, J. P.; Nakajima, R.; Paolillo, M.; Puddu, E.; Radovich, M.; Rifatto, A.; Tortora, C; Valentijn, E. A.; Vellucci, C.; Vriend, W-J.; Amon, A.; Blake, C.; Choi, A.; Fenech Conti, I.; Herbonnet, R.; Heymans, C.; Hoekstra, H.; Klaes, D.; Merten, J.; Miller, L.; Schneider, P.; Viola, M.

    2017-01-01

    KiDS-ESO-DR3 contains a multi-band source catalogue encompassing all publicly released tiles, a total of 440 survey tiles including the coadded images, weight maps, masks and source lists of 292 survey tiles of KiDS-ESO-DR3, adding to the 148 tiles released previously (50 in KiDS-ESO-DR1 and 98 in

  9. Van kind tot jong volwassene: Die ontwikkeling van die hoofkarakter in De koperen tuin van Simon Vestdijk

    Directory of Open Access Journals (Sweden)

    B. van der Westhuizen

    2001-08-01

    Full Text Available From child to young adult: The development of the main character in De koperen tuin (The garden where the brass band played by Simon Vestdijk From an intertextual study it emerges that the postulated view of reality in the psychological-philosophical text De toekomst der religie (The future of religion (1947 is transposed in narrative form in the text-internal vision of reality in the novel De koperen tuin (The garden where the brass band played (1950. In both these texts the religious point of departure of the meaning of existence is reflected upon. Existential aspects especially highlighted, include the following: the I, the relationship with others, being involved in the situation, freedom, responsibility, guilt, angst, death, that which is “too-late”. Furthermore the extension of the moment, the directedness at a personal passion, and the individual’s courage to be and to keep “becoming” are also highlighted. All these aspects emphasizing existentialism are portrayed in the development of the main character, Nol Rieske, from little boy to young adult.

  10. Toetsen en trainen van gevaarherkenning : onderzoek naar de toetsbaarheid en trainbaarheid van gevaarherkenning bij jonge beginnende automobilisten in 2007.

    NARCIS (Netherlands)

    Vlakveld, W.P.

    2008-01-01

    Hazard perception is considered to be an essential part of the driving task. In young novice drivers, however, hazard perception still is poorly developed. In its research programme for the period 2007-2010, SWOV therefore wishes to investigate the possibilities to measure and train hazard perceptio

  11. Gunstige invloed van een standaardeliminatiedieet op het gedrag van jonge kinderen met aandachtstekorthyperactiviteitsstoornis (ADHD), een verkennend onderzoek.

    NARCIS (Netherlands)

    Pelsser, L.M.J.

    2002-01-01

    OBJECTIVE: To determine whether a standard elimination diet can decrease the ADHD-symptoms in a heterogeneous group of young children with ADHD. DESIGN: Open, descriptive. METHOD: 40 children, 36 boys and 4 girls, aged 3-7 (average 4.8 years), who met the DSM-IV-criteria for ADHD, followed their usu

  12. Toetsen en trainen van gevaarherkenning : onderzoek naar de toetsbaarheid en trainbaarheid van gevaarherkenning bij jonge beginnende automobilisten in 2007.

    NARCIS (Netherlands)

    Vlakveld, W.P.

    2008-01-01

    Hazard perception is considered to be an essential part of the driving task. In young novice drivers, however, hazard perception still is poorly developed. In its research programme for the period 2007-2010, SWOV therefore wishes to investigate the possibilities to measure and train hazard

  13. Transcending borders. Arabs, Politics, Trade and Islam in Southeast Asia, Huub de Jonge & Nico Kaptein (éds

    Directory of Open Access Journals (Sweden)

    Rémy Madinier

    2013-01-01

    Full Text Available Délaissée près d’un siècle durant par les spécialistes, la communauté arabe d’Asie du sud-est est depuis quelques années l’objet d’un renouveau d’intérêt, dans lequel s’inscrit cet ouvrage collectif. Tiré d’un atelier intitulé « les Arabes en Asie du Sud-Est » tenu à Leyde en décembre 1997, le volume rassemble neuf contributions, précédées d’une utile introduction générale. Les différents articles ne sont pas regroupés en fonction d’un plan d’ensemble, ce que l’on peut regretter, d’autant qu’...

  14. De invloed van geïdealiseerde mediabeelden op het zelfbeeld van jonge meisjes: Het positieve effect van mediabewustzijn.

    NARCIS (Netherlands)

    Deen, van der F.S.; Schwinghammer, S.A.; Verkooijen, K.T.

    2011-01-01

    This study examines the influence of idealised (extremely attractive) models appearing in beauty advertisements on the self-image of 10-13 year-old girls and investigates the possible protective role of media awareness. Model attractiveness (idealised vs. normally attractive) and media awareness

  15. VizieR Online Data Catalog: KiDS-ESO-DR2 multi-band source catalog (de Jong+, 2015)

    NARCIS (Netherlands)

    de Jong, J. T. A.; Verdoes Kleijn, G. A.; Boxhoorn, D. R.; Buddelmeijer, H.; Capaccioli, M.; Getman, F.; Grado, A.; Helmich, E.; Huang, Z.; Irisarri, N.; Kuijken, K.; La Barbera, F.; McFarland, J. P.; Napolitano, N. R.; Radovich, M.; Sikkema, G.; Valentijn, E. A.; Begeman, K. G.; Brescia, M.; Cavuoti, S.; Choi, A.; Cordes, O.-M.; Covone, G.; Dall'Ora, M.; Hildebrandt, H.; Longo, G.; Nakajima, R.; Paolillo, M.; Puddu, E.; Rifatto, A.; Tortora, C.; van Uitert, E.; Buddendiek, A.; Harnois-Deraps, J.; Erben, T.; Eriksen, M. B.; Heymans, C.; Hoekstra, H.; Joachimi, B.; Kitching, T. D.; Klaes, D.; Koopmans, L. V. E.; Koehlinger, F.; Roy, N.; Sifon, C.; Schneider, P.; Sutherland, W. J.; Viola, M.; Vriend, W.-J.

    2017-01-01

    KiDS data releases consist of ~1 square degree tiles that have been successfully observed in all four survey filters (u,g,r,i). The second data release (KiDS-ESO-DR2) was available in February 2015 and contains imaging data, masks and single-band source lists for all tiles observed in all four filte

  16. North Korea -- Still an Intelligence Problem

    Directory of Open Access Journals (Sweden)

    Stephan Blancke

    2014-06-01

    Full Text Available A few years after Kim Jong Un came into office, North Korea is still attracting controversy in the headlines, and political sanctions are still in operation. Despite the harsh measures in place to isolate Pyongyang from sources of money and luxury, the rulers are able to get what they want using front companies or the help of other states. The reasons for this are deeply rooted in the North Korean political structure. A network of high ranking officials, their children, and political minions are grappling for power and wealth. Beside the powerful Kim clan there exist other families in North Korea whose loyalty must be secured with bribes. If the loyalty of the influential families is eroded, the power base of Kim Jong Un is likely to soon diminish. As a result, the North Korean government is searching for sources of money. Illicit drugs may be one solution the ruling regime find attractive to this problem, but there appears to be a twist: struggling ordinary citizens are showing signs that they too are taking part in this illegal enterprise. This is manifested by their willingness to become involved in crime in the same way as the corrupt regime.

  17. Terveisiä erakkovaltiosta : Pohjois-Korea suomalaisessa uutisdiskurssissa

    OpenAIRE

    Vähäaho, Sanna

    2016-01-01

    Tässä opinnäytetyössä pyrin selvittämään, miten Korean demokraattisesta kansantasavallasta (Pohjois-Korea) puhutaan Ilta-Sanomissa ja Helsingin Sanomissa. Haluan selvittää miten Pohjois-Koreaa kuvaillaan valtiona, sen kansaa ihmisinä ja Kim Jong-unia johtajana. Lähestyn aihepiiriä diskurssianalyysin keinoin. Ilta-Sanomat ja Helsingin Sanomat ovat osa Sanoma-konsernia ja muodostavat siksi mielenkiintoisen vertailuparin. Molemmat ilmestyvät päivittäin ja niitä luetaan ympäri Suomen. Ilta-Sa...

  18. North Korea, Nuclear Weapons, and No Good Options?

    DEFF Research Database (Denmark)

    Cohen, Michael David

    2013-01-01

    How would Pyongyang’s development of the capability to target the United States with nuclear weapons influence North Korea’s foreign policy? I argue that it would cause more dangerous crises than those of the last decade, and predict that these crises would eventually cause Kim Jong Un and his...... senior military associates to experience fear of imminent nuclear war or conventional regime change. I show that the effect of such fear would depend on whether or not Kim believes that he has control over the occurrence of these events. I argue that if he experiences fear and believes that he has some...... control over whether these extreme events actually happen, he will moderate his nuclear threats and behave more like other experienced nuclear powers. But if he experiences fear and believes that he has no control, he will likely pursue policies that could cause nuclear war. I use this insight...

  19. Type 2-diabetes--en heterogen sygdom med kim i fostertilstanden

    DEFF Research Database (Denmark)

    Vaag, Allan

    2012-01-01

    environment may take centre stage in the global propagation of T2D. Impaired expandability of subcutaneous adipose tissue in persons with low birthweight may cause T2D due to lipotoxicity in non-adipose organs. Future implications include a stronger focus on individualized treatments in T2D patients...

  20. Koo Yuen Kim, D.P.T.J, J.P

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ The grandfather of Koo was living in the closed and undeveloped China during the early ages of last century. As not to tolerate with the suffering days of hungry and poverty, he began his new life in far region of South China Sea. Relying on the bare industrious hands, Koo's grandfather managed to lead out the hard life. Later, Koo's father,the second generation of Malaysian Chinese was bom on the land of Malaya during the years of the turbulent period of history. Koo's father worked extremely hard as expecting for one day of returning ancestral hometown.

  1. Systemically applied insecticides for treatment of erythrina gall wasp, quadrastichus erythrinae kim hymenoptera: Eulophidae

    Science.gov (United States)

    Doccola, J.J.; Smith, S.L.; Strom, B.L.; Medeiros, A.C.; Von Allmen, E.

    2009-01-01

    Abstract The erythrina gall wasp (EGW), believed native to Africa, is a recently described species and now serious invasive pest of Erythrina (coral trees) in tropical and subtropical locales. Erythrina are favored ornamental and landscape trees, as well as native members of threatened ecosystems. The EGW is a tiny, highly mobile, highly invasive wasp that deforms (galls) host trees causing severe defoliation and tree death. The first detection of EGW in the United States was in O'ahu, Hawai'i in April 2005. It quickly spread through the Hawai'ian island chain (U.S.) killing ornamental and native Erythrina in as little as two years. At risk are endemic populations of Erythrinaas well as ornamental landscape species in the same genus, the latter of which have already been killed and removed from O'ahu at a cost of more than USD $1 million. Because EGW are so small and spread so quickly, host injury is usually detected before adult wasps are observed, making prophylactic treatments less likely than therapeutic ones. This study evaluates two stem-injected insecticides, imidacloprid (IMA-jet??) and emamectin benzoate, delivered through Arborjet Tree I.V.?? equipment, for their ability to affect E. sandwicensis (wiliwili) canopy demise under severe EGW exposure. IMA-jet, applied at a rate of 0.16 g AI/cm basal diameter (0.4 g AI/in. dia.), was the only effective treatment for maintaining canopy condition of wiliwili trees. Emamectin benzoate, applied at a rate of -0.1 g AI/cm basal diameter (-0.25 g AI/in. dia.), was not effective in this application, although it was intermediate in effect between IMA-jet and untreated trees. The relatively high concentrations of imidacloprid in leaves, and its durability for at least 13 months in native wiliwili growing on a natural, dryland site, suggest that treatment applications against EGW can impact canopy recovery even under suboptimal site and tree conditions. ?? 2009 International Society of Arboriculture.

  2. VizieR Online Data Catalog: NIR sources in the northeastern part of LMC (Kim+, 2016)

    Science.gov (United States)

    Kim, J.; Jeong, W.-S.; Pak, S.; Park, W.-K.; Tamura, M.

    2016-02-01

    We observed the northeastern regions of the LMC using the infrared camera SIRIUS and the polarimeter SIRPOL at the Infrared Survey Facility (IRSF) 1.4m telescope at the South African Astronomical Observatory (SAAO) on 2008 December 25-30 and 2011 December 2-11; in the J (1.25um), H (1.63um), and Ks (2.14um) bands. (1 data file).

  3. VizieR Online Data Catalog: Properties of asteroids in comet-like orbits (Kim+, 2014)

    Science.gov (United States)

    Kim, Y.; Ishiguro, M.; Usui, F.

    2017-03-01

    We used infrared asteroid databases compiled from three infrared all-sky surveyors, the IRAS (Neugebauer et al. 1984ApJ...278L..83N), AKARI (Murakami et al. 2007PASJ...59S.369M), and the Wide-field Infrared Survey Explorer (WISE; Wright et al. 2010AJ....140.1868W). Usui et al. (2014, J/PASJ/63/1117) compared these three infrared asteroid catalogs with valid sizes and albedos and merged them into a single catalog (I-A-W). They archived 138,285 asteroids with sizes and albedos, detected with either IRAS, AKARI, or WISE in I-A-W. A number of asteroids were detected by two or three satellites: 1993 asteroids by all three satellites, 2812 asteroids by AKARI and WISE, and 312 asteroids by IRAS and WISE. In such cases, Usui et al. (2014, J/PASJ/63/1117) selected data from AKARI as the highest priority, WISE as the second, and IRAS as the third priority, although there are no remarkable differences in the sizes and albedos among these catalogs. AKARI data were given highest priority because its data have less uncertainty than WISE in the sizes and albedos for the largest asteroids. We used the I-A-W catalog in the analysis of ACOs. (1 data file).

  4. North Korea after Kim Chong-il: Leadership Dynamics and Potential Crisis Scenarios

    Science.gov (United States)

    2011-11-01

    were increased, in order to get rid of enforced artificial pricing and bring commerce (on such commodities as rice ) into line with market prices...See “Brother-in-Law Seen as Having Gained Real Power in DPRK,” AERA, 20 April 2009; and “Morning Star General to Turn Water into Wine ,” The Daily...Far East, Japan , and South Korea, with little indication of government attempts to intervene80  Widespread movement of population within country in

  5. The first clinical treatment with kilovoltage intrafraction monitoring (KIM): A real-time image guidance method

    DEFF Research Database (Denmark)

    Keall, Paul J.; Aun Ng, Jin; O'Brien, Ricky;

    2015-01-01

    system. A 120° pretreatment kV imaging arc was acquired to build the patient-specific 2D to 3D motion correlation. The kV imager was activated during the megavoltage (MV) treatment, a dual arc VMAT prostate treatment, to estimate the 3D prostate position in real-time. All necessary ethics, legal...

  6. Concept Development of “Nursing Presence”: Application of Schwartz-Barcott and Kim's Hybrid Model

    Directory of Open Access Journals (Sweden)

    Fatemeh Mohammadipour, PhD

    2017-03-01

    Conclusion: Co-constructed interaction underscored the value of the nursing presence as an integral component of caring with humanistic and patient-centered approaches. The findings could help clinical nurses have a better understanding of the nursing presence. Findings also can improve educators' and managers' knowledge for developing and conducting appropriate education strategies and caring activities to facilitate the promotion of nursing presence.

  7. Production of Recombinant Injectosome and Outer Membrane Proteins from Yersinia Pestis KIM5

    Science.gov (United States)

    2009-06-01

    undergraduate research facilities and local public heath offices, include fermenters , autoclaves, centrifuges, and incubators (Shea 2004). These...glycerol fermentation and nitrate 16 reduction abilities and geographic location. These phenotypic variations have been assumed to represent...White colonies, representing clones with inserts, were picked and used to inoculate 3 mL LB broth [50 ug/mL KAN] at 37°C at 225 RPM overnight

  8. Dr Jung Hyun KIM Vice Minister for Education, Science and Technology MEST Republic of Korea

    CERN Multimedia

    Jean-Claude Gadmer

    2010-01-01

    He learnt about CERN's LHC computing grid project from Frédéric Hemmer, head of the information technology department. In addition, the vice-minister toured the ATLAS visitor centre, the CMS control centre, the ALICE experiment's exhibition and control room, and he met Korean scientists at CERN.

  9. Type 2-diabetes--en heterogen sygdom med kim i fostertilstanden

    DEFF Research Database (Denmark)

    Vaag, Allan

    2012-01-01

    Type 2 diabetes (T2D) is a heterogeneous disease with a multifactorial aetiology involving defects in the pancreatic beta cells, liver, muscles, adipose tissue, guts, brain, kidneys and heart. While genetics may only explain a minor proportion of T2D, the contribution of an adverse intrauterine...... environment may take centre stage in the global propagation of T2D. Impaired expandability of subcutaneous adipose tissue in persons with low birthweight may cause T2D due to lipotoxicity in non-adipose organs. Future implications include a stronger focus on individualized treatments in T2D patients...

  10. Seroprevalence of HIV in women attending antenatal clinic at KIMS hospital, Narketpally

    Directory of Open Access Journals (Sweden)

    Venna Guru Prasad

    2012-12-01

    Full Text Available Background: To assess seroprevalence of HIV among antenatal women and the extent of utilization of therapeutic interventions to minimize the risk of mother to child transmission. Methods: Pregnant women attending antenatal clinic of a medical college in a rural area of Nalgonda district of Andhra Pradesh, India from August 2006 to July 2009 were tested for HIV by Rapid Test which included pre and post test counseling. Antiretroviral prophylaxis with nevirapine was given to seropositive mother-baby pairs during delivery. Results: Of the 5809 new antenatal booking visits 4848 attended pretest counseling and 4698 accepted HIV testing. Fifty three women were found to be seropositive. Sero-prevalence rate of HIV infection was 1.12%. Ten had opted for pregnancy termination. Out of forty three deliveries four were intrauterine deaths. All the newborns received nevirapine prophylaxis. Conclusions: The seroprevalence of HIV infection among antenatal women is 1.12% which was high as the institute is located in Andhra Pradesh which is a known high prevalence state. Thirty one babies tested after 18 months of age were negative. Nine babies died before they reached 18 months of age. [Int J Reprod Contracept Obstet Gynecol 2012; 1(1.000: 17-21

  11. TUBERCULIN RESPONSIVENESS AS A PROGNOSTIC INDICATOR IN HIV POSITIVE PULMONARY TUBERCULOSIS, KIMS, AMALAPURUM

    Directory of Open Access Journals (Sweden)

    Nagaraja

    2014-11-01

    Full Text Available With the emergence of HIV pandemic there is an alarming increase in both HIV and Tuberculosis cases cause’s major health problems due to poor socio-economic status in developing and resource poor countries. HIV and Tuberculosis infection hand in hand kills more population than all other infections combined. Both HIV and Tuberculosis is a major health problem. So the present study is under taken to know present scenario of HIV and TB in the rural set up, Amalapuram, East Godavari District, Andhra Pradesh. Out of 100 suspected cases with HIV and Tuberculosis with malnutrition, 10 samples were found to be HIV positive by rapid and ELISA. Among 10 positive HIV cases 6 cases were found to be positive for AFB by ZN stain indicating both HIV and Tuberculosis go hand in hand.

  12. Primena GIS-a u hidrološkim istraživanjima - primer reke Lepenice

    Directory of Open Access Journals (Sweden)

    Milanović Ana

    2007-01-01

    Full Text Available The basic component of GIS technology (Geographical Information Systems is the base of graphical data, which can be used for geographical definition of spaces elements- entities. As a new, modern, technology, it has more application in different hydrological researches. In GIS creation Lepenica river basin, it was applied softwares: Micro Station, GeoMedia, Surfer 7. Map and AutoCAD. After data base creation, it was enabled for users to get different information of Lepenica river basin on the simple way. Getting data are used for creation of three thematic maps (altitude zones map, hydrographical net map and precipitation isoline map.

  13. MYCOLOGICAL PROFILE OF DERMATOPHYTES ISOLATED FROM CLINICAL SAMPLES IN KIMS HOSPITAL, BANGALORE

    Directory of Open Access Journals (Sweden)

    Anjana

    2015-01-01

    Full Text Available The dermatophytoses constitute a group of superficial fungal infections of keratinised tissue - epidermis, hair and nails, caused by a closely related group of filamentous fungi, the dermatophytes. OBJECTIVES: Isolation and speciation of dermatophytes by culture and to determine its prevalence. METHODOLOGY: The study was conducted from January 2012 - December 2013 at Kempegowda institute of medical sciences, Bangalore. All clinically suspected cases coming to the microbiology department where subjected to mycological work - up. Specimens like skin scraping, hair, and nail were collected and microscopically examined using 10%, 20% and 40% KOH respectively for fungal filaments. Culture was carried out using Sabouraud dextrose agar medium with and without cycloheximide. The growth in the culture tube was speciated based on the macroscopic and microscopic findings (with Lactophenol cotton blue staining. RESULTS: Total cases in the two year period were 609. The infection was found to be common in adults aged 20 - 30 years, the male to female ratio is 1.2:1. The KOH positives were 491(80%, and culture positives were 471(77%. Of the positive cultures Trichophyton rubrum (35% was the common isolate followed by Trichophyton mentagrophytes (17%, and Epidermophyton floccosum (6%. CONCLUSION : In the present study the most common clinical presentation is Tinea corporis followed by Tinea unguium and Tinea cruris and the common isolate was T.rubrum. The present study was undertaken to determine the clinical pattern of dermatophytosis and the common species that was prevalent here.

  14. Rak izletshim u 80 iz 100 zabolevshihh detei / Lev Durnov ; interv. Kim Smirnov

    Index Scriptorium Estoniae

    Durnov, Lev

    1999-01-01

    Intervjuu Venemaa N. Blohhini nimelise Onkoloogia Teadusliku Keskuse peadirektori asetäitja Lev Durnoviga keskuseLaste Onkoloogia ja Hematoloogia Teadusliku Uurimise Instituudi tööst laste vähktõve ravimisel

  15. Rak izletshim u 80 iz 100 zabolevshihh detei / Lev Durnov ; interv. Kim Smirnov

    Index Scriptorium Estoniae

    Durnov, Lev

    1999-01-01

    Intervjuu Venemaa N. Blohhini nimelise Onkoloogia Teadusliku Keskuse peadirektori asetäitja Lev Durnoviga keskuseLaste Onkoloogia ja Hematoloogia Teadusliku Uurimise Instituudi tööst laste vähktõve ravimisel

  16. A Grand Challenge: Immortal Information and Through-Life Knowledge Management (KIM

    Directory of Open Access Journals (Sweden)

    Alexander Ball

    2006-11-01

    Full Text Available ‘Immortal information and through-life knowledge management: strategies and tools for the emerging product-service business paradigm’, is a Grand Challenge project involving eleven different UK universities and incorporating substantial industry collaboration. It is investigating a range of issues associated with the move towards a product-service paradigm in the engineering sector, in particular the long-term curation of digital data, learning from production and use, and appropriate governance and management techniques.

  17. 艺木家:金坶·克劳斯(Kim Krause)

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    金姆·克劳斯2007年创作了一组名为“时间/变化”的画作,这些画里,缎带、旗帜、纸环人、色盘、号角、碎花纸以及其他聚会用的个人装备色彩明亮地缠结在一起,从帆布的顶端悬垂下来,飘荡到一个色彩丰富的空间。

  18. Matematika u vojnotehničkim dostignućima / Mathematics in military-technical achievements

    Directory of Open Access Journals (Sweden)

    Natalija B. Jelenković

    2010-10-01

    Full Text Available Matematika se definiše kao vrsta filozofije ili pogleda na svet, sredstvo za razvijanje apstraktnog mišljenja, a služi i za pojednostavljenje prirodnih nauka. Prilično je specijalna - izučava količinu i poredak; uopšteno, to je nauka o formalnim strukturama. Ona je i kombinacija slobode kreativne misli i strogih logičkih pravila, ali i deduktivna nauka koja daje pravila i zakone pomoću kojih baratamo brojevima i prostorom. Kao takva, matematika je i savremeni alat za vojnotehnička dostignuća modernog doba, kao što su: sve vrste radio i radio-relejnih veza, radarska sredstva, sredstva za upravljanje, navigaciju, televizijska, optoelektronska, hidro- akustična sredstva, sredstva za protivelektronsku borbu, kao i mnoga elektronska tehnička sredstava, naoružanje i vojna oprema Kopnene vojske, Vazduhoplovstva i protiv-vazduhoplovne odbrane, Ratne mornarice. Prethodno istaknute definicije matematike su korišćene kao osnova za uopšteno sistematizovano izlaganje metodom uporednog opisivanja, nabrajanjem činjenica, definisanjem pojmova. Cilj članka je da se na osnovu nabrojanja postojećih primena matematike i proširivanjem znanja može dalje napredovati u istraživanju mnogih vojnih oblasti. Pored toga, članak ima i pedagoški cilj, a to je da kroz opise i karakteristike sredstava ratne tehnike zainteresuje i afirmiše značaj i lepotu vojnog poziva. Rezultati razvoja informacionih tehnologija su, pored ostalog, i savršenija vojnotehnička dostignuća, a predstavljaju i inspiraciju za mnoge inovacije i uspehe. / In this article, mathematics is dealt with as a science necessary for the design, development and implementation of certain military-technical achievements such as many electronic devices, smart missiles, miniature antennas, camouflage military clothing and other military equipment. Some areas of applied, discrete and continuous mathematics are underlined in particular. Application of mathematics The importance of mathematics for military-technical achievements is reflected in the fact that mathematics allowed the existence and development of military disciplines such as: fortifications, military statistics, military economics, cryptography, military psychology, air force, military-technical and military information science. There are also many applications using mathematical models and linear programming. Mathematics is thus necessary and indispensable as a tool, a way of expression and communication, as well as the basic creation of further progress. This article reveals the connection of mathematics and certain military areas that are important for the development of the armed forces and war materiel. The application of mathematics in military- technical achievements is entailed in the connection of mathematics with military disciplines. Information technology - Basic concepts Some identified problems occurring in military purposes are mentioned through some basic concepts and benefits related to information technology. Comparative description and listing of characteristic traits resulting in the noticed and given advantages and disadvantages highlighted the creation of information technologies, first by using conventional programs and programming and then by using artificial intelligence and expert systems.

  19. Leadership Change in North Korean Politics: The Succession to Kim Il Sung

    Science.gov (United States)

    1988-10-01

    became a "guiding star" as early as 1973. In 1977, he was depicted as the "future sun" and the "blessed sunshine ." He has not yet been called the "sun...34 but "future sun" and "blessed sunshine " indicate that he is the future leader, following his father. In recent years, the father and the son have been...image to be destroyed after his death. Rather, he is eager to eternalize the leader-father image through generations. It is therefore prudent to

  20. Sinise ookeani strateegia : konkurentsi vältimise kunst / W. Chan Kim, Renee Mauborgne

    Index Scriptorium Estoniae

    Kim, W. Chan, 1952-

    2006-01-01

    Sinise ookeani strateegia õpetab, kuidas tegutseda konkurentidest vabal turul. Kommenteerib Hansapanga juhatuse esimees Erkki Raasuke. Lisad: Sinine ookean Tartus; Punane ookean versus sinine ookean. Tabel: Sinise ookeani loomise ajaloost

  1. The role of relA and spoT in Yersinia pestis KIM5 pathogenicity.

    Directory of Open Access Journals (Sweden)

    Wei Sun

    Full Text Available The ppGpp molecule is part of a highly conserved regulatory system for mediating the growth response to various environmental conditions. This mechanism may represent a common strategy whereby pathogens such as Yersinia pestis, the causative agent of plague, regulate the virulence gene programs required for invasion, survival and persistence within host cells to match the capacity for growth. The products of the relA and spoT genes carry out ppGpp synthesis. To investigate the role of ppGpp on growth, protein synthesis, gene expression and virulence, we constructed a Delta relA Delta spoT Y. pestis mutant. The mutant was no longer able to synthesize ppGpp in response to amino acid or carbon starvation, as expected. We also found that it exhibited several novel phenotypes, including a reduced growth rate and autoaggregation at 26 degrees C. In addition, there was a reduction in the level of secretion of key virulence proteins and the mutant was > 1,000-fold less virulent than its wild-type parent strain. Mice vaccinated subcutaneously (s.c. with 2.5x10(4 CFU of the Delta relA Delta spoT mutant developed high anti-Y. pestis serum IgG titers, were completely protected against s.c. challenge with 1.5x10(5 CFU of virulent Y. pestis and partially protected (60% survival against pulmonary challenge with 2.0x10(4 CFU of virulent Y. pestis. Our results indicate that ppGpp represents an important virulence determinant in Y. pestis and the Delta relA Delta spoT mutant strain is a promising vaccine candidate to provide protection against plague.

  2. A live attenuated strain of Yersinia pestis KIM as a vaccine against plague.

    Science.gov (United States)

    Sun, Wei; Six, David; Kuang, Xiaoying; Roland, Kenneth L; Raetz, Christian R H; Curtiss, Roy

    2011-04-01

    Yersinia pestis, the causative agent of plague, is a potential weapon of bioterrorism. Y. pestis evades the innate immune system by synthesizing tetra-acylated lipid A with poor Toll-like receptor 4 (TLR4)-stimulating activity at 37°C, whereas hexa-acylated lipid A, a potent TLR4 agonist, is made at lower temperatures. Synthesis of Escherichia coli LpxL, which transfers the secondary laurate chain to the 2'-position of lipid A, in Y. pestis results in production of hexa-acylated lipid A at 37°C, leading to significant attenuation of virulence. Previously, we described a Y. pestis vaccine strain in which crp expression is under the control of the arabinose-regulated araC P(BAD) promoter, resulting in a 4-5 log reduction in virulence. To reduce the virulence of the crp promoter mutant further, we introduced E. coli lpxL into the Y. pestis chromosome. The χ10030(pCD1Ap) (ΔlpxP32::P(lpxL)lpxL ΔP(crp21)::TT araC P(BAD)crp) construct likewise produced hexa-acylated lipid A at 37°C and was significantly more attenuated than strains harboring each individual mutation. The LD(50) of the mutant in mice, when administered subcutaneously or intranasally was >10(7)-times and >10(4)-times greater than wild type, respectively. Mice immunized subcutaneously with a single dose of the mutant were completely protected against a subcutaneous challenge of 3.6×10(7) wild-type Y. pestis and significantly protected (80% survival) against a pulmonary challenge of 1.2×10(4) live cells. Intranasal immunization also provided significant protection against challenges by both routes. This mutant is an immunogenic, highly attenuated live Y. pestis construct that merits further development as a vaccine candidate.

  3. Korea(n) divided : Third space existence in Kim Ki Duk's Wild Animals

    OpenAIRE

    Hübinette, Tobias

    2004-01-01

    International adoption from Korea constitutes the background to this study. The forced migration of Korean children has by now continued for over half a century, resulting in a diaspora of more than 150,000 adopted Koreans dispersed among 15 main host countries on the continents of Europe, North America and Oceania. Both the demographic scope, the time span and the geographic spread are absolutely unique in a comparative historical child migratory perspective, and still over 2,000 children le...

  4. Sinise ookeani strateegia : konkurentsi vältimise kunst / W. Chan Kim, Renee Mauborgne

    Index Scriptorium Estoniae

    Kim, W. Chan, 1952-

    2006-01-01

    Sinise ookeani strateegia õpetab, kuidas tegutseda konkurentidest vabal turul. Kommenteerib Hansapanga juhatuse esimees Erkki Raasuke. Lisad: Sinine ookean Tartus; Punane ookean versus sinine ookean. Tabel: Sinise ookeani loomise ajaloost

  5. Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation

    Directory of Open Access Journals (Sweden)

    Yoon TH

    2012-03-01

    Full Text Available Ki-Chun Yoo1, Chang-Hwan Yoon1, Dongwook Kwon2, Kyung-Hwan Hyun1, Soo Jung Woo1, Rae-Kwon Kim1, Eun-Jung Lim1, Yongjoon Suh1, Min-Jung Kim1, Tae Hyun Yoon2, Su-Jae Lee11Laboratory of Molecular Biochemistry, 2Laboratory of Nanoscale Characterization and Environmental Chemistry, Department of Chemistry, Hanyang University, Seoul, Republic of KoreaBackground: Titanium dioxide (TiO2 has been widely used in many areas, including biomedicine, cosmetics, and environmental engineering. Recently, it has become evident that some TiO2 particles have a considerable cytotoxic effect in normal human cells. However, the molecular basis for the cytotoxicity of TiO2 has yet to be defined.Methods and results: In this study, we demonstrated that combined treatment with TiO2 nanoparticles sized less than 100 nm and ultraviolet A irradiation induces apoptotic cell death through reactive oxygen species-dependent upregulation of Fas and conformational activation of Bax in normal human cells. Treatment with P25 TiO2 nanoparticles with a hydrodynamic size distribution centered around 70 nm (TiO2P25–70 together with ultraviolet A irradiation-induced caspase-dependent apoptotic cell death, accompanied by transcriptional upregulation of the death receptor, Fas, and conformational activation of Bax. In line with these results, knockdown of either Fas or Bax with specific siRNA significantly inhibited TiO2-induced apoptotic cell death. Moreover, inhibition of reactive oxygen species with an antioxidant, N-acetyl-L-cysteine, clearly suppressed upregulation of Fas, conformational activation of Bax, and subsequent apoptotic cell death in response to combination treatment using TiO2P25–70 and ultraviolet A irradiation.Conclusion: These results indicate that sub-100 nm sized TiO2 treatment under ultraviolet A irradiation induces apoptotic cell death through reactive oxygen species-mediated upregulation of the death receptor, Fas, and activation of the preapoptotic protein

  6. Jong en anders. Onderzoek naar de aandacht voor lesbische, homo, bi-jongeren, transgenderjongeren en jongeren met een intersekse conditie in de jeugdsector

    Directory of Open Access Journals (Sweden)

    Michelle Emmen

    2015-09-01

    Full Text Available Young and different. Research on the attention paid to lesbian, gay, bisexual and transgender youth and young people with an intersex condition in the youth field  Because young LGBT people tend to have worse mental health and become suicidal more often (Kuyper, 2015; Van Bergen & Van Lisdonk, 2010; Kuyper 2015; Collier, Bos & Sandfort 2013; Van Beusekom, Collier, Bos & Sandfort, 2014; Keuzenkamp, 2012, it is to be expected that they are in touch with professionals in the field of youth care more regularly. Hitherto, no research has been conducted into the question of whether LGBT individuals are overrepresented in the field of youth care, so it is unclear whether this is indeed the case. It is also unknown how many individuals with an intersex condition are treated through youth care channels. We do know, however, that there are issues with regard to this target group that are relevant for youth care. These young people are not always registered as such by professionals (Abdallah, De Boer, Bouwens & Bos, 2007; De Boer, Sonneveld, Abdallah, Manesh & Bos, 2009; Felten & Boote, 2012, LGBTi feelings or identity are rarely discussed (Van Denzel, Van Driel & Vondel, 2014, and few professionals take action in the sense of providing for the specific needs, questions and problems on the part of LGBT young people. At the same time, professionals do have questions and learning needs with regard to discussing LGBT issues with individual young people and in groups (Abdallah et al., 2007; JoU, 2013. In 2014, research first took place in the Netherlands into the extent to which professionals working with young people are aware of the existence of, and the specific risks, needs and problems associated with LGBT young people and young people with an intersex condition (Rossenberg, 2013; Van Lisdonk, 2014, and the nature of this awareness. This took the form of a descriptive questionnaire study among 421 professionals, in addition to qualitative input from an expert meeting. The questionnaire was divided into separate questions about lesbian, gay and bisexual young people, questions on transgender youth, and questions on young people with an intersex condition. The questions about the first two groups of young people concern the four themes: registration, discussion, action and learning needs and questions. The questions regarding young people with an intersex condition focus exclusively on registration, since it was expected that professionals do not distinguish between these young people and may even be unaware of the existence of an intersex condition. In the analysis, a chi-squared test was used to look for indications that respondents with specific characteristics would respond differently to the questions. The group of respondents who consider themselves as heterosexual, and the group who indicated that they are gay, lesbian, bisexual, queer, transgender or different, showed significant[1] differences in their responses to parts of the questionnaire. This study shows that professionals’ awareness of and sensitivity to the sexual preferences and gender identity of young people in the youth field is not self-evident. There is a lack of knowledge about these young people: professionals do register LGBT feelings, but do so less often than may be assumed on the basis of figures on the number of LGBTi young people[2]. Nine percent of respondents have never consciously met an LGB young person and 47% have never registered transgender feelings. None of the respondents are familiar with young people with an intersex condition. Some 60% of professionals do not or only rarely discuss assumptions of LGB feelings, while for transgender young people the figure is 71%. Only a minority of professionals act on the LGBT identity of the young person, for instance by focusing on specific LGBT objectives or by referring to specialist care, and 70% never do so with transgender young people. Professionals do not connect LGBT feelings with the other mental and social problems these young people may have: “I find it unnecessary (to discuss LGBT feelings if it’s not a problem”. They do not see LGBT feelings as something special and do not consider that they have a role in supporting young people in discovering and learning to deal with their LGBT feelings. The lack of information on the difficulties experienced by LGBT young people, in combination with an inability to provide adequate support and a lack of direction, cause LGBT young people in the youth field to be overlooked. However, most professionals, 81%, do have questions in this area and need to learn more about the field of LGBTi issues. The fact that professionals see no role for themselves in supporting LGBT young people may be related to the fact that they see an LGBT orientation as “nothing special”. Professionals do not realize that the young people themselves do find it special to discover their own LGB feelings. Usually it takes them a few years before they dare to discuss it with someone else (Kuyper, 2015a; Van Lisdonk & Van Bergen, 2010. It is the same for transgender young people, whose physical gender is not in line with the gender they identify with: that is indeed something special. Professionals tend to reason on the basis of their own tolerant adult perspective and avoid discussing LGBT orientations as something special. This study shows that LGBTi young people very often do not receive the right kind of support. We would like their care to include an acknowledgement of their “being different” and of their specific needs, wishes and problems. This leads us to recommendations on three levels: to municipalities, to organizations in the youth field and to professionals. At the municipal level, it is important to incorporate LGBTi in local policy and in the requirements for calls for tender. Organizations in the field of youth care should include the theme of LGBTi in their diversity policies, and operationalize the issue into suggestions for questions concerning sexual and gender diversity in the intake. At the level of professionals, further research would be useful: action research to determine what kinds of specific competences are needed to support LGBTi young people. Incorporating these competences into the curriculums of universities of applied science will ensure that future professionals know how to support LGBTi young people. SAMENVATTINGJong en anders. Onderzoek naar de aandacht voor lesbische, homo, bi-jongeren, transgenderjongeren en jongeren met een intersekse conditie in de jeugdsectorOmdat LHBT-jongeren een slechtere psychische gezondheid hebben en vaker suïcidaal zijn (Kuyper, 2015; Van Bergen & Van Lisdonk, 2010; Kuyper 2015; Collier, Bos & Sandfort, 2013; Van Beusekom, Collier, Bos & Sandfort, 2014; Keuzenkamp, 2012 ligt het voor de hand dat zij vaker in aanraking komen met professionals in de jeugdsector. In 2014 is voor het eerst in Nederland een onderzoek uitgevoerd naar de mate waarin en op welke manier er onder professionals die werken met jongeren aandacht is voor het bestaan, de specifieke risico’s, behoeften en problemen van LHBT-jongeren en jongeren met een intersekse conditie (Rossenberg, 2013; Van Lisdonk, 2014. Het gaat om een beschrijvend vragenlijstonderzoek onder 421 professionals, aangevuld met kwalitatieve input uit een expertmeeting. Uit de resultaten blijkt dat aandacht van professionals voor seksuele voorkeur en genderidentiteit niet vanzelfsprekend is. Er is sprake van een gebrek aan kennis over deze jongeren: 41% weet niet hoe te signaleren dat een jongere worstelt met LHB-gevoelens en voor transgenderjongeren is dat 64%. Geen van de respondenten ontmoette ooit bewust een jongere met een intersekse conditie. Professionals brengen LHBT-gevoelens niet in verband met andere psychische en sociale problemen die deze jongeren hebben. Zij ervaren LHBT-gevoelens zelf niet als iets bijzonders en zien geen rol voor zichzelf in het ondersteunen van de betreffende jongeren. De combinatie van een gebrek aan kennis van de moeilijkheden die LHBTi-jongeren ervaren en het bestaan van handelingsverlegenheid en een gebrek aan handelingsperspectief zorgt ervoor dat aandacht voor LHBTi-jongeren in de jeugdsector niet vanzelfsprekend is.

  7. De invloed van etniciteit van jonge verdachten op beslissingen van het Openbaar Ministerie = The impact of young suspects' ethnicity on prosecutorial deciscion

    NARCIS (Netherlands)

    Weenink, D.

    2007-01-01

    In de vs bestaat er een traditie van sociologisch onderzoek naar de ongelijke behandeling van etnische minderheden in het justitieel systeem. Het zwaartepunt ligt daarbij op analyses van beslissingen door de rechterlijke macht. Uit het gros van de studies blijkt dat etnische minderheden zwaarder wor

  8. Jong en anders. Onderzoek naar de aandacht voor lesbische, homo, bi-jongeren, transgenderjongeren en jongeren met een intersekse conditie in de jeugdsector

    National Research Council Canada - National Science Library

    Michelle Emmen; Hanneke Felten; Anne Addink; Pieter Paul Bakker; Maurits Boote; Saskia Keuzenkamp

    2015-01-01

    Young and different. Research on the attention paid to lesbian, gay, bisexual and transgender youth and young people with an intersex condition in the youth field Because young LGBT people tend to have worse mental...

  9. The De Jong Gierveld short scales for emotional and social loneliness: Tested on data from seven countries in the UN Generations and Gender Surveys

    NARCIS (Netherlands)

    Jong-Gierveld, de J.; Tilburg, van T.G.

    2010-01-01

    Loneliness concerns the subjective evaluation of the situation individuals are involved in, characterized either by a number of relationships with friends and colleagues which is smaller than is considered desirable (social loneliness), as well as situations where the intimacy in confidant

  10. The De Jong Gierveld short scales for emotional and social loneliness: tested on data from 7 countries in the UN Generations and Gender Surveys

    NARCIS (Netherlands)

    de Jong Gierveld, J.; van Tilburg, T.

    2010-01-01

    Loneliness concerns the subjective evaluation of the situation individuals are involved in, characterized either by a number of relationships with friends and colleagues which is smaller than is considered desirable (social loneliness), as well as situations where the intimacy in confidant relations

  11. The De Jong Gierveld short scales for emotional and social loneliness: Tested on data from seven countries in the UN Generations and Gender Surveys

    NARCIS (Netherlands)

    Jong-Gierveld, de J.; Tilburg, van T.G.

    2010-01-01

    Loneliness concerns the subjective evaluation of the situation individuals are involved in, characterized either by a number of relationships with friends and colleagues which is smaller than is considered desirable (social loneliness), as well as situations where the intimacy in confidant relations

  12. 冷战格局下的朝鲜经济改革%North Korea’ s Economic Reform in Cold-War Structure

    Institute of Scientific and Technical Information of China (English)

    三村光弘; 王静(译)

    2014-01-01

    朝鲜经济改革始于1998年修宪。在金正日时代历经国有企业重组、改变经济规划方法、改变企业管理方法、调整工资和价格过程。金正恩时代的朝鲜经济政策继承了金正日时代经济改革措施的特点。朝鲜社会科学院( KASS)经济研究所教授李基松(音)2013年5月在接受日本记者采访时表示,朝鲜已实施“土地担当制”或土地承包责任制政策并给予农户对于超额农作物的处置权;朝鲜国有企业已实行新独立核算制度。朝鲜经济政策根本性变革已可见端倪。但朝鲜核问题使东北亚特别是朝鲜半岛地区冷战格局犹存。%An economic reform in North Korea started at the time when the Socialist Constitution was amended in 1998 .Economic reform in North Korea started in restructuring of state -owned enterprises , followed by changes in the economic planning method , changes in enterprise management methods , and review of salary and price in Kim Jong Il era .North Korean economic policy in Kim Jong Un era inherits characteristics from economic reform measures in Kim Jong Il era .Ri Ki Song , a professor of institute of economy , Korea Academy of Social Sciences (KASS) said in an interview to Japanese journalists in May 2013, that “pojeon tamdangjae” or a policy to assign three to five agricultural workers to one field continuously has been in force and granted power of disposition of the crop they produced more than the quota .He also said that the new self -supporting accounting system has been set force in state-owned enterprises .Essential change in North Korean economic policy could be bud flush .However , we should be aware that we have still Cold -War structure in Northeast Asia , especially here in Korean Peninsula , by the presence of North Korean nuclear problem .

  13. Reference: 154 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available nase in Arabidopsis. 5712 1111-3 15618487 2005 Feb Science (New York, N.Y.) Kwak Su-Hwan|Schiefelbein John|Shen Ronglai ... 154 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15618487i Kwak Su-Hwan et al. 2005 Fe

  14. Improving dissolution and oral bioavailability of pranlukast hemihydrate by particle surface modification with surfactants and homogenization

    Directory of Open Access Journals (Sweden)

    Ha ES

    2015-06-01

    Full Text Available Eun-Sol Ha,1 In-hwan Baek,2 Jin-Wook Yoo,1 Yunjin Jung,1 Min-Soo Kim1 1College of Pharmacy, Pusan National University, 2College of Pharmacy, Kyungsung University, Busan, Republic of Korea Abstract: The present study was carried out to develop an oral formulation of pranlukast hemihydrate with improved dissolution and oral bioavailability using a surface-modified microparticle. Based on solubility measurements, surface-modified pranlukast hemihydrate microparticles were manufactured using the spray-drying method with hydroxypropylmethyl cellulose, sucrose laurate, and water and without the use of an organic solvent. The hydrophilicity of the surface-modified pranlukast hemihydrate microparticle increased, leading to enhanced dissolution and oral bioavailability of pranlukast hemihydrate without a change in crystallinity. The surface-modified microparticles with an hydroxypropylmethyl cellulose/sucrose laurate ratio of 1:2 showed rapid dissolution of up to 85% within 30 minutes in dissolution medium (pH 6.8 and oral bioavailability higher than that of the commercial product, with approximately 2.5-fold and 3.9-fold increases in area under the curve (AUC0→12 h and peak plasma concentration, respectively. Therefore, the surface-modified microparticle is an effective oral drug delivery system for the poorly water-soluble therapeutic pranlukast hemihydrate. Keywords: solubility, wettability, sucrose laurate, cellulose

  15. Diatoms of the microphytobenthic community in a tropical intertidal sand flat influenced by monsoons: Spatial and temporal variations

    Digital Repository Service at National Institute of Oceanography (India)

    Mitbavkar, S.; Anil, A.C.

    and their asso- ciated microphytobenthos and consequently lower mic- roalgal biomass (Baillie and Welsh 1980; de Jonge and van den Bergs 1987; Delgado et al. 1991; de Jonge 1992; de Jonge and van Beusekom 1992, 1995). Gabrielson and Lukatelich (1985) and de Jonge...

  16. Psikografik Bir Pazar Bölümlendirme Değişkeni Olarak Cinsiyet Kimliği: Tüketim Araştirmalarinda Cinsiyet Kimliği Kavraminin İncelenmesi

    OpenAIRE

    ÇABUK, Prof.Dr. Serap; ARAÇ, Arş.Gör. Selin KÖKSAL

    2013-01-01

    Sex is an important variable of market segmentation to explain consumer behaviour and the effect of sex on attributes attitudes and behaviours of consumers is examined in many of the researches of marketing literature Sex that examined as a demographic variable in consumer behaviour researches means biological sex The other concept “consumer identity” that had appeared in psychology literature since 1930s and had taken effect on consumer researches since 1960s means psychological sex Psyc...

  17. STUDY OF ADOLESCENT ABNORMAL UTERINE BLEEDING (AUB AND ITS OUTCOME - IN TERTIARY CENTRE K.I.M.S. KARAD

    Directory of Open Access Journals (Sweden)

    Manisha M

    2015-08-01

    Full Text Available BACKGROUND/AIMS: Menstruation is a normal part of adolescence, but for girls with excessive uterine bleeding, it can be associated with significant morbidity . Menstrual disorders and abnormal uterine bleeding (AUB are among the most frequent gynaecological complaints of adolescents . AUB has been defined in the past by a variety of terms and there have been inconsistencies and lack of categorization of various potential causes of AUB. To have standard nomenclature internationally, palm coein Classification of AUB was introduced in 2011 by FIGO Menstrual disorder group for non - pregnant, reproductive age women. In the present study we ai med to evaluate cases of adolescent AUB by investigations and palm coein approach. METHOD S : The study was conducted prospectively on all adolescent girls attending OPD at Krishna institute of medical sciences Karad, Menstrual complaints were classified according to palm coein approach after a thorough history taking, examination and investigation s. RESULTS: Prevalence of menstrual disorders in adolescents was 64.5%, of which 86.90% were attributed to AUB. Palm coein approach was applied to AUB cases. Ovulatory disorders (AUB - 0 formed a major chunk of adolescent AUB (96.90%, of which 60.60% were due to immaturity of Hypothalamic Pituitary Ovarian axis, 27.87% due to polycystic ovarian syn drome and 8.48% due to Thyroid disorders. Contribution of coagulopathy to AUB was 2.42%. Polyps and leiomyoma were seen in 1.2% and 0.6% of cases respectively. A ll cases were classified when palm coein was applied. CONCLUSION: AUB in adolescents can also be classified by palm coein to standardize nomenclature and abandonment of terms like menorrhagia, metrorrhagia and dysfunc tional uterine bleeding and treated it successfully.

  18. VizieR Online Data Catalog: Low-resolution near-infrared stellar spectra from CIBER (Kim+, 2017)

    Science.gov (United States)

    Kim, M. G.; Lee, H. M.; Arai, T.; Bock, J.; Cooray, A.; Jeong, W.-S.; Kim, S. J.; Korngut, P.; Lanz, A.; Lee, D. H.; Lee, M. G.; Matsumoto, T.; Matsuura, S.; Nam, U. W.; Onishi, Y.; Shirahata, M.; Smidt, J.; Tsumura, K.; Yamamura, I.; Zemcov, M.

    2017-06-01

    We present flux-calibrated near-infrared spectra of 105 stars from 0.8{prism-dispersed spectrometer with five rectangular 5.35°*2.8' slits imaging a 5.8°*5.8° field of view. The detector has 256*256 pixels at a pixel scale of 1.36'*1.36'. CIBER has flown four times (2009 February, 2010 July, 2012 March, and 2013 June) with apogees and total exposure times of over 325km and ~240s, respectively, in the first three flights and of 550km and 335s in the final, non-recovered flight. Due to spurious signal contamination from thermal emission from the shock-heated rocket skin, we do not use the first flight data in this work. The star spectral types are determined by fitting known spectral templates to the measured LRS spectra. We use the Infrared Telescope Facility (IRTF) and Pickles 1998 (Cat. J/PASP/110/863) templates for the SED fitting. The SpeX instrument installed on the IRTF observed stars using a medium-resolution spectrograph (R=2000). The template library contains spectra for 210 cool stars (F to M type) with wavelength coverage from 0.8 to 2.5μm (Cushing 2005ApJ...623.1115C; Rayner 2009ApJS..185..289R). The Pickles library is a synthetic spectral library that combines spectral data from various observations to achieve wavelength coverage from the UV (0.115μm) to the near-infrared (2.5μm). It contains 131 spectral templates for all star types (i.e., O to M type) with a uniform sampling interval of 5Å. (6 data files).

  19. Savremene metode analize ulja u tehničkim sistemima / Modern methods of oil analysis in technical systems

    Directory of Open Access Journals (Sweden)

    Sreten R. Perić

    2010-01-01

    Full Text Available Analiza ulja na osnovu pravilno definisanog programa predstavlja veoma efikasan metod monitoringa stanja tehničkih sistema koji obezbeđuje rane upozoravajuće znake potencijalnih problema, koji vode ka otkazu i zastoju tehničkih sistema. Ova analiza je veoma efikasan alat programa za monitoring stanja tehničkih sistema. Mnogobrojni uređaji i testovi za analizu ulja omogućavaju kvalitetan monitoring i dijagnosticiranje problema koji nastaju u procesu podmazivanja. Korišćenjem programa za analizu motornih ulja: skraćuje se neplanirano vreme otkaza vozila, poboljšava pouzdanost vozila, produžava radni vek motora, optimizira interval zamene ulja i smanjuju troškovi održavanja vozila. / Different technical systems require an appropriate lubricant to be used at an appropriate place, at appropriate time and in appropriate quantity. Determination of technical systems condition has a very important role in the development of theory and practice of friction, wear and lubrication. Lubricant is, as a contact element of tribomechanical systems, a carrier of information about the state of the whole system, from the aspect of tribological and other ageing processes. The analysis of oils, based on a properly defined program, thus represents a very effective method for monitoring the condition of technical systems, which ensures early warning signals of potential problems that could lead to failure and break down of technical systems. Introduction It is not always simple to determine a type of lubricant, frequency of lubrication and the quantity of lubricant to be used. The optimal recommendation would be to follow specifications of technical system manufacturers, experience, lab research or professional recommendation of lubricant suppliers. Rational lubricant consumption can be obtained by timely oil replacement, which then enables a maximum possible period of use as well as high-quality lubrication. Since the primary role of lubricants is to reduce negative effects of tribological processes related to friction, wear and temperature increase in tribomechanical systems, all types of maintenance include lubrication as a very important part of the whole procedure. On the other hand, lubricant is, as a contact element of the system, a carrier of information about the condition of the whole system, from the aspect of tribological and other ageing processes. Therefore, an analysis of oils, based on a properly defined program, represents a very effective method for monitoring the condition of technical systems, which ensures early warning signals of potential problems that could lead to failure and break down of technical systems. Besides mechanical components in a system structure, the condition of lubricant itself is also affected, which leads to a loss of lubricating properties. Contamination and degradation of lubricating oils There are numerous opportunities for contamination and degradation of lubricating oils. Contamination and degradation of oil exploitation cannot be completely prevented, but can be significantly reduced, which is very important both for oil and for a technical system itself. The rate and degree of degradation of oil are proportional to the rate and extent of contamination. It is therefore important to prevent rapid contamination of oil, before and during use. The spectrum of oil contaminants is considerably wide. Any contaminant destructive impact on oil, reducing its physical-chemical and working properties, results in shortening its service life as well as the service life of the technical system in question. During oil exploitation, changes occur in: chemical compositions and properties of base oils, chemical compositions and properties of additives, and consequently chemical compositions of oils in general, as a result of contamination and degradation. The most significant oil contaminants are base oils degradation products, additives degradation products, metal particles as a result of wear processes, solid particles from the environment, water and products of fuel combustion. During the operation the following changes occur: contamination of oil by the products of its own degradation, by products of incomplete combustion of fuel and by contaminants of various origin. The main objectives of the analysis and monitoring of oil exploitation in vehicles The main objectives of the analysis and monitoring of oil exploitation in vehicles are: - analysis of system element wear processes, - analysis of lubricant contamination processes, - monitoring changes in the properties of lubricants in order to optimize the life of system functionality control (penetration of contaminants, temperature and pressure, filter efficiency, etc. and - determining the extent of damage and causes of failure. The analysis of the contents of different metals in lubricants is very important. Metal particles are abrasive, and act as catalysts in oil oxidation. In motor oils, they can originate from additives, wear processes, fuel, air and cooling liquid. Metals from additives may be Zn, Ca, Ba, or Mg and they indicate additive deterioration. Metals originating from wear are: Fe, Pb, Cu, Cr, Al, Mn, Ag, Sn, and they point to increased wear in these systems. The elements originating from cooling liquids are Na and B, and their increased content indicates the penetration of cooling liquid in the lubricant. The increased content of Si or Ca, which originate from the air, points to a malfunction of the air filter. Condition monitoring through oil analysis tests There are many different types of oil analysis tests that are used to evaluate lubricants. The tests must cover three areas: technical system condition, contamination condition, and lubricant condition. From the technical system condition aspect, attention should be paid to the presence of any metal particles in oil and the tendencies in their change. The second focus would be the lubricant condition, especially viscosity change, increase in oxidation, and signs of additive depletion. The third focus would be impurities, where the emphasis should be placed on particle number, water content and metal impurities. Theoretically, oil analyses are divided into three classes. In reality, all three condition-monitoring classes are interrelated and must be considered as a whole. For example, an increase in viscosity could be an indication that a lubricant is oxidizing. But oxidation could be an incorrect conclusion, if there is no indication of an increasing oxidation tendency obtained either by the acid number (AN values analysis or the Fourier Transform-Infrared (FT-IR analysis. Lubricant monitoring enables its refreshing or replacement before serious technical system damage occurs. If damage is noticed in the course of operation, and is caused by impurities or lubricant problems, the technical system condition can be monitored and the system may be shut down immediately to minimize damage. There are the two types of alarms, i.e. warning signs used in oil analysis: absolute and statistical alarms. An effective oil analysis relies on the combination of both types. The warning limit is the absolute alarm. The statistical tendency takes into account variability based on oil sampling and its contamination and represents the standard deviation. The deviation from the normal variability indicates serious problems, which is the first signal for taking action and dealing with the problem. As the deviation tendency approaches the warning limit, oil replacement, oil purification or a system inspection is required. Metal particles content and viscosity or some other parameters can be tested. The normal variability range takes into account minor variations caused by analytical accuracy, sample homogeneity, etc. Statistical alarms, which provide the earliest possible warning without false alarms, are difficult to achieve. The factors such as oil adding or changing, filter changes and a sampling technique can distort the results. The following tests are most frequently used in technical system condition monitoring: - Spectrometric Analysis, - Analytical Ferrography, - Rotrode Filter Spectroscopy (RFS, - Infrared Analysis (FT-IR, - Viscosity, - Total acid number (TAN, - Total Base Number (TBN - Water and Particle Count.

  20. PROMENE KRVNOG PRITISKA U TOKU TESTA FIZIČKIM OPTEREĆENJEM KOD NORMOTENZIVNIH I HIPERTENZIVNIH REKREATIVACA

    Directory of Open Access Journals (Sweden)

    Mirko Šaranović

    2008-08-01

    Full Text Available Background. Arterial hypertension is a leading cause of morbidity in developed countries. It often decreases functional capacities of the cardiovascular system. Changes of pressure during physical exercise are a very significant a prognostic factor. Aim. The aim of this investigation was to assess changes of blood pressure and heart rate during exercise in normotensive and hypertensive men involved in recreational physical activity. Methods. The study included 90 young men (aged 30-40 years involved in recreation (60 with hypertension, 30 with normal pressure. The bicycle ergometer test was performed after rest, the load increased gradually from 50 to 125W. Blood pressure and heart rate were measured at rest and during the exercise. Results. Systolic and diastolic pressure increased signifi cantly in both groups during the ergometry test, compared to the values at rest. This increase was higher among hypertensive men for every graduation of test load (p<0.05. Heart rate was similar in both groups at rest, but higher values were noted among hypertensive men (p<0.05.

  1. Uporaba abrazivnog vodenog mlaza za mjerenje zaostalih naprezanja u željezničkim kotačima

    OpenAIRE

    Hlaváček, Petr; Brumek, Jan; Horsák, Lukáš

    2012-01-01

    The paper provides a general introduction to methods of measurement of residual stresses on railway wheels. Determination of residual stress distribution is necessary for the prediction of wheel service life and possible catastrophic failure. Therefore experimental section is devoted to residual stress measurement using strain gauges according to standard EN 13262 + A1. During measurement, several segments of tested wheel were cut by abrasive water jet to detect changes of residual s...

  2. Growth of a plasmid-bearing (pYV) Yersinia pestis KIM5 in retail raw ground pork

    Science.gov (United States)

    Yersinia pestis can cause oro-pharyngeal plague as a result of consumption or handling of meat from infected animals. Thus, food naturally or intentionally contaminated can have a role in the dissemination of human plague. The growth of a conditionally virulent plasmid (pYV)-bearing rifampicin-res...

  3. CORRELATION OF OBESITY, INSULIN RE SI S TANCE AND LIPID PROFILE IN WOMEN WITH PCOS IN KIMS HOSPITAL BANGALORE

    Directory of Open Access Journals (Sweden)

    Shashikala H

    2015-03-01

    Full Text Available BACKGROUND : Polycystic ovary syndrome is a condition associated with chronic anovulation, insulin resistance and androgen excess. Dyslipidemia, diabetes, obesity are all potent cardiovascular risk factors that tend to cluster in women with PCOD. These cannot be explained by obesity alone. Thus the need arises to study the effect of insulin resistance on these factors. This will help in assessing the long term cardiovascular morbidity in PCOD patients and take necessary preventive steps. OBJECTIVES : To analyze the infuence of obesity on lipid profile of PCOS women. To analyze the influence of insulin resistance on lipid profile in PCOS women. MATERIALS AND METHODS : In this prospective study done from December 2013 to September 2014, 50 women with PCOS had their body mass index and waist to hip ratio calculated. GTT, fasting and post prandial insulin, lipid profile was also done for each case. Insulin resistance was defined by fasting glucose to insulin ratio of less than or equal to 4.5. The association of obesity markers and insulin resistance with lipid markers was then studied. Statistical analysis using Student t test and ANOVA was done as indicated. Significance is assessed at 5% level of significance. RESULTS : Insulin resistance was seen in 56 percent of the cases. There was no correlation between markers of obesity (BMI and Waist to Hip ratio and the various lipid parameters. But in PCOS women with insulin resistance the lipid profile was significantly different (high triglycerides and lower high density lipoprotein compared to the insulin sensitive women. The difference between the two groups for triglycerides and HDL was statistically significant but that for LDL and total cholesterol was not statistically significant. CONCLUSION : Insulin resistance is associated with dyslipidemia in women with PCOS, independent of obesity.

  4. Report on the Second KIMS-CNA Conference: The PLA Navys Build-Up and ROK-USN Cooperation

    Science.gov (United States)

    2009-02-01

    are located in the Asia-Pacific: the Southwest Asian Seas, with the Malacca and Lombok Straits among others and sea lanes of communication (SLOCs...or Southeast Asia. If these routes were no longer cheap or safe, ships would use other routes, such as the Straits of Lombok and Makassar, or even...35 The Malacca and Lombok /Makassar Straits in Southeast Asia are an especially heavily burdened area in

  5. Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients

    Directory of Open Access Journals (Sweden)

    Jeong S

    2016-07-01

    Full Text Available Sohyun Jeong,1 In-Wha Kim,1 Kook-Hwan Oh,2 Nayoung Han,1 Kwon Wook Joo,2 Hyo Jin Kim,2 Jung Mi Oh1 1College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, 2Department of Internal Medicine, Division of Nephrology, Seoul National University Hospital, Seoul, Korea Background: Secondary hyperparathyroidism (SHPT is one of the major risk factors of morbidity and mortality in end-stage renal disease. Cinacalcet effectively controls SHPT without causing hypercalcemia and hyperphosphatemia. However, there is significant inter-individual response variance to cinacalcet treatment. Therefore, we aimed to evaluate the genetic effects related with parathyroid hormone regulation as factors for cinacalcet response variance. Methods: Patients with a diagnosis of SHPT based on intact parathyroid hormone (iPTH >300 pg/mL on dialysis were included in this study. They were over 18 years and have been treated by cinacalcet for more than 3 months. Responders and nonresponders were grouped by the serum iPTH changes. Twenty-four single nucleotide polymorphisms of CASR, VDR, FGFR1, KL, ALPL, RGS14, NR4A2, and PTHLH genes were selected for the pharmacogenetic analysis. Results: After adjusting for age, sex, and calcium level, CASR rs1042636 (odds ratio [OR]: 0.066, P=0.027 and rs1802757 (OR: 10.532, P=0.042 were associated with cinacalcet response. The association of haplotypes of CASR rs1042636, rs10190, and rs1802757; GCC (OR: 0.355, P=0.015; and ATT (OR: 2.769, P=0.014 with cinacalcet response was also significant. Conclusion: We obtained supporting information of the associations between cinacalcet response and CASR polymorphisms. CASR single nucleotide polymorphisms (SNPs rs1802757, rs1042636, and haplotypes of rs1042636, rs10190, and rs1802757 were significantly associated with cinacalcet response variance. Keywords: CASR, calcium sensing receptor, SHPT, genetic polymorphisms, haplotype, single nucleotide polymorphisms

  6. Subsurface temperature estimation from climatology and satellite SST for the sea around Korean Peninsula 1Bong-Guk, Kim, 1Yang-Ki, Cho, 1Bong-Gwan, Kim, 1Young-Gi, Kim, 1Ji-Hoon, Jung 1School of Earth and Environmental Sciences, Seoul National University

    Science.gov (United States)

    Kim, Bong-Guk; Cho, Yang-Ki; Kim, Bong-Gwan; Kim, Young-Gi; Jung, Ji-Hoon

    2015-04-01

    Subsurface temperature plays an important role in determining heat contents in the upper ocean which are crucial in long-term and short-term weather systems. Furthermore, subsurface temperature affects significantly ocean ecology. In this study, a simple and practical algorithm has proposed. If we assume that subsurface temperature changes are proportional to surface heating or cooling, subsurface temperature at each depth (Sub_temp) can be estimated as follows PIC whereiis depth index, Clm_temp is temperature from climatology, dif0 is temperature difference between satellite and climatology in the surface, and ratio is ratio of temperature variability in each depth to surface temperature variability. Subsurface temperatures using this algorithm from climatology (WOA2013) and satellite SST (OSTIA) where calculated in the sea around Korean peninsula. Validation result with in-situ observation data show good agreement in the upper 50 m layer with RMSE (root mean square error) less than 2 K. The RMSE is smallest with less than 1 K in winter when surface mixed layer is thick, and largest with about 2~3 K in summer when surface mixed layer is shallow. The strong thermocline and large variability of the mixed layer depth might result in large RMSE in summer. Applying of mixed layer depth information for the algorithm may improve subsurface temperature estimation in summer. Spatial-temporal details on the improvement and its causes will be discussed.

  7. North Korea, Quo Vadis?

    Directory of Open Access Journals (Sweden)

    Karl H. Stingeder

    2014-03-01

    Full Text Available North Korean politics appears neither irrational nor unpredictable: the logic of its actions may at first seem opaque, but it nonetheless displays its own rationale and patterns. – North Korea: a ruthless political actor, now under the leadership of Kim Jong-Un who inherited the regime’s leadership from his father and "Supreme Leader", Kim Jong-Il, in 2011. The country’s policy is based on its ongoing political agenda of (nuclear brinkmanship, a true threat to the world – or at least that's how the Western hemisphere sees it. Yet our factual knowledge of this post-Leninist and totalitarian regime is extremely limited and relatively distorted; it is largely circumstantial evidence and judgmental speculation that accounts for our perception of this East Asian state. Northeast Asia (China, Japan, South and North Korea, Taiwan is a region dominated by the legacy of the Cold War. The North Korean leadership has indeed established its priorities, primarily its isolationist orientation, but in the long term the regime cannot survive without external stimulus. Most importantly, even in a long-term, non-violent and gradual transformation of North Korea considerable danger can ultimately result in the demise of the regime. Apart from few signs of a North Korean "civil society", currently only the army might have the resources to see through a regime change. In the meantime, the strategies of isolationism as well as tight control of the media remain as fundamental cornerstones of the regime. A close-knit network of social control has been established and access to the internet for the most part is limited to the regime’s entrusted cadre.

  8. Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet

    Directory of Open Access Journals (Sweden)

    Kim JY

    2014-01-01

    Full Text Available Joo-Yeon Kim,1,* Mak-Soon Lee,1,* Sunyoon Jung,1 Hyunjin Joo,1 Chong-Tai Kim,2 In-Hwan Kim,3 Sangjin Seo,1 Soojung Oh,1 Yangha Kim11Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Republic of Korea; 2Functional Materials Research Group, Korea Food Research Institute, Seongnam, Gyeonggi, Republic of Korea; 3Department of Food and Nutrition, Korea University, Seoul, Republic of Korea *These authors contributed equally to this workPurpose: This study determined the effects of oleoresin capsicum (OC and nanoemulsion OC (NOC on obesity in obese rats fed a high-fat diet.Methods: The rats were randomly separated into three groups: a high-fat (HF diet group, HF + OC diet group, and HF + NOC diet group. All groups were fed the diet and water ad libitum for 14 weeks.Results: NOC reduced the body weight and adipose tissue mass, whereas OC did not. OC and NOC reduced mRNA levels of adipogenic genes, including peroxisome proliferator-activated receptor (PPAR-γ, sterol regulatory element-binding protein-1c, and fatty acid-binding protein in white adipose tissue. The mRNA levels of genes related to β-oxidation or thermogenesis including PPAR-α, palmitoyltransferase-1α, and uncoupling protein-2 were increased by the OC and NOC relative to the HF group. Both OC and NOC clearly stimulated AMP-activated protein kinase (AMPK activity. In particular, PPAR-α, palmitoyltransferase-1α, uncoupling protein-2 expression, and AMPK activity were significantly increased in the NOC group compared to in the OC group. NOC decreased glycerol-3-phosphate dehydrogenase activity whereas OC did not.Conclusion: From these results, NOC could be suggested as a potential anti-obesity agent in obese rats fed a HF diet. The effects of the NOC on obesity were associated with changes of multiple gene expression, activation of AMPK, and inhibition of glycerol-3-phosphate dehydrogenase in white adipose tissue.Keywords: oleoresin capsicum

  9. Enzyme-responsive doxorubicin release from dendrimer nanoparticles for anticancer drug delivery

    Directory of Open Access Journals (Sweden)

    Lee SJ

    2015-08-01

    Full Text Available Sang Joon Lee,1,* Young-Il Jeong,2,* Hyung-Kyu Park,3 Dae Hwan Kang,2,4 Jong-Suk Oh,3 Sam-Gyu Lee,5 Hyun Chul Lee31Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju, 2Biomedical Research Institute, Pusan National University Hospital, Busan, 3Department of Microbiology, Chonnam National University Medical School, Gwangju, 4Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Gyeongnam, 5Department of Physical and Rehabilitation Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea*These authors contributed equally to this workBackground: Since cancer cells are normally over-expressed cathepsin B, we synthesized dendrimer-methoxy poly(ethylene glycol (MPEG-doxorubicin (DOX conjugates using a cathepsin B-cleavable peptide for anticancer drug targeting.Methods: Gly-Phe-Leu-Gly peptide was conjugated with the carboxylic acid end groups of a dendrimer, which was then conjugated with MPEG amine and doxorubicin by aid of carbodiimide chemistry (abbreviated as DendGDP. Dendrimer-MPEG-DOX conjugates without Gly-Phe-Leu-Gly peptide linkage was also synthesized for comparison (DendDP. Nanoparticles were then prepared using a dialysis procedure.Results: The synthesized DendGDP was confirmed with 1H nuclear magnetic resonance spectroscopy. The DendDP and DendGDP nanoparticles had a small particle size of less than 200 nm and had a spherical morphology. DendGDP had cathepsin B-sensitive drug release properties while DendDP did not show cathepsin B sensitivity. Further, DendGDP had improved anticancer activity when compared with doxorubicin or DendDP in an in vivo CT26 tumor xenograft model, ie, the volume of the CT26 tumor xenograft was significantly inhibited when compared with xenografts treated with doxorubicin or DendDP nanoparticles. The DendGDP nanoparticles were found to be relatively concentrated in the tumor tissue and

  10. Measuring negative symptoms in patients with schizophrenia: reliability and validity of the Korean version of the Motivation and Pleasure Scale-Self-Report

    Directory of Open Access Journals (Sweden)

    Kim JS

    2016-05-01

    Full Text Available Ji-Sun Kim,1 Seon-Kyeong Jang,1 Seon-Cheol Park,2 Jung-Seo Yi,3 Joong-Kyu Park,4 Jung Suk Lee,5 Kee-Hong Choi,6 Seung-Hwan Lee1,7 1Clinical Emotion and Cognition Research Laboratory, Goyang, 2Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, 3Department of Psychiatry, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, 4Department of Rehabilitation Psychology, Daegu University, Daegu, 5Department of Psychiatry, National Health Insurance Service Ilsan Hospital, Goyang, 6Department of Psychology, Korea University, Seoul, 7Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea Background: The Clinical Assessment Interview for Negative Symptoms (CAINS is one of the validated interview measures of negative symptoms in psychotic disorders. The Motivation and Pleasure Scale-Self-Report (MPSR is a self-report measure that assesses the motivation and pleasure domains of negative symptoms based on the CAINS. This study evaluated the reliability and validity of a Korean version of the MPSR.Methods: A total of 139 patients with schizophrenia completed the MPSR, CAINS, Scale for the Assessment of Negative Symptoms (SANS, Brief Psychiatric Rating Scales, Calgary Depression Scale for Schizophrenia, and other measures of trait and cognitive function.Results: The 15-item MPSR showed good internal consistency. In addition, it also had a good convergent validity with the Motivation and Pleasure subscale of the CAINS and the anhedonia/avolition subscale of the SANS. The scale was not associated with psychotic symptoms, agitation/mania, and depression/anxiety, and it showed good discriminant validity. MPSR scores were significantly correlated with Behavioral Activation System total score for trait measure.Conclusion: The Korean version of the MPSR is a notable self-report method for examining the severity of negative symptoms in schizophrenia. Keywords: Korean

  11. Analysis of zinc oxide nanoparticles binding proteins in rat blood and brain homogenate

    Directory of Open Access Journals (Sweden)

    Shim KH

    2014-12-01

    Full Text Available Kyu Hwan Shim,1 John Hulme,1 Eun Ho Maeng,2 Meyoung-Kon Kim,3 Seong Soo A An1 1Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Sungnam-si, Gyeonggi-do, South Korea; 2Department of Analysis, KTR, Kimpo, Gyeonggi-do, South Korea; 3Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea Abstract: Nanoparticles (NPs are currently used in chemical, cosmetic, pharmaceutical, and electronic products. Nevertheless, limited safety information is available for many NPs, especially in terms of their interactions with various binding proteins, leading to potential toxic effects. Zinc oxide (ZnO NPs are included in the formulation of new products, such as adhesives, batteries, ceramics, cosmetics, cement, glass, ointments, paints, pigments, and supplementary foods, resulting in increased human exposures to ZnO. Hence, we investigated the potential ZnO nanotoxic pathways by analyzing the adsorbed proteins, called protein corona, from blood and brain from four ZnO NPs, ZnOSM20(-, ZnOSM20(+, ZnOAE100(-, and ZnOAE100(+, in order to understand their potential mechanisms in vivo. Through this study, liquid chromatography–mass spectroscopy/mass spectroscopy technology was employed to identify all bound proteins. Totals of 52 and 58 plasma proteins were identified as being bound to ZnOSM20(- and ZnOSM20(+, respectively. For ZnOAE100(- and ZnOAE100(+, 58 and 44 proteins were bound, respectively. Similar numbers of proteins were adsorbed onto ZnO irrespective of size or surface charge of the nanoparticle. These proteins were further analyzed with ClueGO, a Cytoscape plugin, which provided gene ontology and the biological interaction processes of identified proteins. Interactions between diverse proteins and ZnO nanoparticles could result in an alteration of their functions, conformation, and clearance, eventually affecting many biological processes. Keywords: brain

  12. Fabrication and evaluation of valsartan–polymer–surfactant composite nanoparticles by using the supercritical antisolvent process

    Directory of Open Access Journals (Sweden)

    Kim MS

    2014-11-01

    Full Text Available Min-Soo Kim,1 In-hwan Baek21College of Pharmacy, Pusan National University, Geumjeong-gu, Busan, Republic of Korea; 2College of Pharmacy, Kyungsung University, Daeyeon-dong, Nam-gu, Busan, Republic of KoreaAbstract: The aim of this study was to fabricate valsartan composite nanoparticles by using the supercritical antisolvent (SAS process, and to evaluate the correlation between in vitro dissolution and in vivo pharmacokinetic parameters for the poorly water-soluble drug valsartan. Spherical composite nanoparticles with a mean size smaller than 400 nm, which contained valsartan, were successfully fabricated by using the SAS process. X-ray diffraction and thermal analyses indicated that valsartan was present in an amorphous form within the composite nanoparticles. The in vitro dissolution and oral bioavailability of valsartan were dramatically enhanced by the composite nanoparticles. Valsartan–hydroxypropyl methylcellulose–poloxamer 407 nanoparticles exhibited faster drug release (up to 90% within 10 minutes under all dissolution conditions and higher oral bioavailability than the raw material, with an approximately 7.2-fold higher maximum plasma concentration. In addition, there was a positive linear correlation between the pharmacokinetic parameters and the in vitro dissolution efficiency. Therefore, the preparation of composite nanoparticles with valsartan–hydroxypropyl methylcellulose and poloxamer 407 by using the SAS process could be an effective formulation strategy for the development of a new dosage form of valsartan with high oral bioavailability.Keywords: supersaturation, bioavailability, solid dispersion, dissolution, supercritical fluid

  13. 5-aminolevulinic acid-incorporated poly(vinyl alcohol nanofiber-coated metal stent for application in photodynamic therapy

    Directory of Open Access Journals (Sweden)

    Kang DH

    2012-05-01

    Full Text Available Jin Ju Yoo*, Chan Kim*, Chung-Wook Chung, Young-Il Jeong, Dae Hwan KangNational Research and Development Center for Hepatibiliary Disease, Pusan National University Yangsan Hospital, Gyeongnam 626-770, Korea *These authors contributed equally to this work.Background: The study investigated the use of combined photodynamic therapy (PDT and stent placement for the treatment of cholangiocarcinoma (CC. For this purpose, 5-aminolevulinic acid (ALA was incorporated into poly(vinyl alcohol (PVA nanofiber, and coated onto metal stents. Their efficacy was assessed in PDT towards HuCC-T1 CC cells.Methods: Fabrication of ALA-PVA nanofiber, and simultaneous coating onto metal stents, was performed through electrospinning. The dark-toxicity, generation of protoporphyrin IX (PpIX, and PDT effect of ALA and ALA-PVA nanofiber were studied in vitro, using HuCC-T1 CC cells.Results: The ALA-PVA nanofibers were coated onto metal stents less than 1000 nm in diameter. ALA-only displayed marginal cytotoxicity; ALA-PVA nanofiber showed less cytotoxicity. PpIX generation was not sigficantly different between ALA and ALA-PVA nanofiber treatments. PVA itself did not generate PpIX in tumor cells. ALA and ALA-PVA nanofiber displayed a similar PDT effect on tumor cells. Cell viability was decreased, dose-dependently, until ALA concentration reached 100 µg/mL. Necrosis and apoptosis of tumor cells occurred similarly for ALA and ALA- PVA nanofiber treatments.Conclusion: The ALA-PVA nanofiber-coated stent is a promising candidate for therapeutic use with cholangiocarcinoma.Keywords: nanofiber, photodynamic therapy, 5-aminolevulinic acid, poly(vinyl alcohol

  14. Entrapment of curcumin into monoolein-based liquid crystalline nanoparticle dispersion for enhancement of stability and anticancer activity

    Directory of Open Access Journals (Sweden)

    Baskaran R

    2014-06-01

    Full Text Available Rengarajan Baskaran,1 Thiagarajan Madheswaran,2 Pasupathi Sundaramoorthy,1 Hwan Mook Kim,1 Bong Kyu Yoo1 1College of Pharmacy, Gachon University, Incheon, South Korea; 2College of Pharmacy Yeungnam University, Gyeongsan, South Korea Abstract: Despite the promising anticancer potential of curcumin, its therapeutic application has been limited, owing to its poor solubility, bioavailability, and chemical fragility. Therefore, various formulation approaches have been attempted to address these problems. In this study, we entrapped curcumin into monoolein (MO-based liquid crystalline nanoparticles (LCNs and evaluated the physicochemical properties and anticancer activity of the LCN dispersion. The results revealed that particles in the curcumin-loaded LCN dispersion were discrete and monodispersed, and that the entrapment efficiency was almost 100%. The stability of curcumin in the dispersion was surprisingly enhanced (about 75% of the curcumin survived after 45 days of storage at 40°C, and the in vitro release of curcumin was sustained (10% or less over 15 days. Fluorescence-activated cell sorting (FACS analysis using a human colon cancer cell line (HCT116 exhibited 99.1% fluorescence gating for 5 µM curcumin-loaded LCN dispersion compared to 1.36% for the same concentration of the drug in dimethyl sulfoxide (DMSO, indicating markedly enhanced cellular uptake. Consistent with the enhanced cellular uptake of curcumin-loaded LCNs, anticancer activity and cell cycle studies demonstrated apoptosis induction when the cells were treated with the LCN dispersion; however, there was neither noticeable cell death nor significant changes in the cell cycle for the same concentration of the drug in DMSO. In conclusion, entrapping curcumin into MO-based LCNs may provide, in the future, a strategy for overcoming the hurdles associated with both the stability and cellular uptake issues of the drug in the treatment of various cancers. Keywords: liquid

  15. Moerasvogels op peil; deelrapport 1: peilen op riet; literatuurstudie naar de sturende processen en factoren voor de achteruitgang en herstel van jonge verlandingspopulaties van riet (Phragmites australis) in laagveenmoerassen en rivierkleigebieden

    NARCIS (Netherlands)

    Belgers, J.D.M.; Arts, G.H.P.

    2003-01-01

    Dit rapport beschrijft de resultaten van een literatuurstudie naar processen en factoren die een rol spelen bij de achteruitgang en het herstel van waterriet. In de literatuur bestaat consensus dat een niet-natuurlijk peilbeheer mede verantwoordelijk is voor het verdwijnen van waterriet. Tevens drag

  16. New leader, new hope for WHO Setting an agenda for Jong-Wook Lee%WHO的新领导和新希望为李钟郁制定一个工作纲领

    Institute of Scientific and Technical Information of China (English)

    Gavin Yamey; Kamran Abbasi

    2003-01-01

    @@ 90年代中期,世界卫生组织(WHO)似乎难以逃脱两种命运--陷入腐败和低效的官僚主义泥潭1或是走向死亡2.然而两者都没有发生.相反,1998年7月成为WHO总干事的布伦特兰(Gro Harlem Brundtland)重振了WHO在全球卫生领域的声望3.

  17. On Statuses of Platonic-Mencuis Theorem and Mr. Zhuo Jong's Theorem in Political Economics%论柏拉图-孟子定理和卓炯定理在政治经济学中的地位

    Institute of Scientific and Technical Information of China (English)

    杨永华

    2005-01-01

    在文化性和技术性的层面上,马克思主义经济学和西方经济学、古代经济思想有若干相同或者近似的研究方法和理论观点.如柏拉图-孟子定理、斯密定理和卓炯定理都是用分工来论证商品交换的必要性,都在分工的基础上构成自己的经济学理论体系.充分认识和理解分工理论的重要性,对于政治经济学建设有重要的理论意义.

  18. Leidlikud lahendused : uus elamuehitus Amsterdamis = Enforcing Ingenuity New Housing in Amsterdam / Hans Ibelings ; hollandi keelest tõlk. eesti keelde Katrin Laiapea ja inglise keelde Robyn de Jong-Dalziel

    Index Scriptorium Estoniae

    Ibelings, Hans

    2001-01-01

    Amsterdami kahe elamurajooni planeeringust. Borneo-Sporenburgi (1994-2001) planeeringu tegi Adriaan Geuze ja tema büroo West 8. Kolm hiigelelamut projekteerisid Koen van Velsen, Frits van Dongen ja Kees Christiaanse. Valmimisjärgus IJburgi planeeringu autorid Felix Claus, Frits van Dongen ja Ton Schaap. 13 ill

  19. Leidlikud lahendused : uus elamuehitus Amsterdamis = Enforcing Ingenuity New Housing in Amsterdam / Hans Ibelings ; hollandi keelest tõlk. eesti keelde Katrin Laiapea ja inglise keelde Robyn de Jong-Dalziel

    Index Scriptorium Estoniae

    Ibelings, Hans

    2001-01-01

    Amsterdami kahe elamurajooni planeeringust. Borneo-Sporenburgi (1994-2001) planeeringu tegi Adriaan Geuze ja tema büroo West 8. Kolm hiigelelamut projekteerisid Koen van Velsen, Frits van Dongen ja Kees Christiaanse. Valmimisjärgus IJburgi planeeringu autorid Felix Claus, Frits van Dongen ja Ton Schaap. 13 ill

  20. "Als het bedrijf er maar niet teveel last van heeft" : de invloed van het ouderschapsbeleid en de ouderschapscultuur van supermarkten en boekhandels op de combinatieproblemen van mannelijke en vrouwelijke werknemers met jonge kinderen

    NARCIS (Netherlands)

    Veenis, E.

    2001-01-01

    What impact do businesses have on the efforts of parents with young children who combine work and family, and what factors within the business play a role in this? This was the principal question in this comparative case study of two retailers, a large supermarket chain and a small group of booksell

  1. Urinary Biomarkers KIM-1 and NGAL for Detection of Chronic Kidney Disease of Uncertain Etiology (CKDu) among Agricultural Communities in Sri Lanka

    OpenAIRE

    De Silva, Pallagae Mangala C. S.; Khaja Shameem Mohammed Abdul; Eakanayake M D V Eakanayake; Sudheera Sammanthi Jayasinghe; Channa Jayasumana; Hewa Bandulage Asanthi; Perera, Hettiarachigae S. D.; Gamage G Tushara Chaminda; Ediriweera P S Chandana; Siribaddana, Sisira H.

    2016-01-01

    Chronic Kidney Disease of uncertain etiology (CKDu) is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that CKDu is a tubulointerstitial disease. Urine albumin or albumin-creatinine ratio is still being used as a traditional diagnostic tool to identify CKDu, but accuracy and prevalence data generated are questionable. Urinary biomarkers have been used in similar nephropathy and are ...

  2. VizieR Online Data Catalog: Very Low-Luminosity Objects (VeLLOs) from 1.25-850um (Kim+, 2016)

    Science.gov (United States)

    Kim, M.-R.; Lee, C. W.; Dunham, M. M.; Evans, N. J., II; Kim, G.; Allen, L. E.

    2016-10-01

    The Spitzer Gould Belt Survey (GBS) is a project to survey about 21 square degrees of 11 nearby molecular clouds at 3.6-160um to provide a census of star formation in nearby large clouds (P.I. L. Allen). Spitzer has mapped a total of 11 molecular clouds, CMC, Chamaeleon I, Chamaeleon III, Musca, Lupus V, Lupus VI, Ophiuchus North, Aquila, CrA, Cepheus, and IC 5146 with the IRAC and MIPS between 2004 March and 2008 October. We utilized the data provided by the c2d/GBS projects (Evans et al. 2009, J/ApJS/181/321; Dunham et al. 2015, J/ApJS/220/11). There are two cloud complexes which were not listed in the c2d/GBS projects, but observed by other projects, the Taurus molecular clouds and the Orion molecular clouds. The Taurus molecular clouds have been observed over an area of ~44 square degrees by one of the GTO programs (P.I. D. Padgett) with the IRAC and the MIPS instruments. The Orion molecular clouds have been surveyed in ~9°2 area by Spitzer (P.I. T. Megeath). See section 2.1 for further details. Complementary archive infrared data were retrieved from 2MASS and Herschel PACS and SPIRE and JCMT SCUBA-2; see section 2.2. We observed our sources with the N2H+(1-0) line with the Korean Very Long Baseline Interferometry Network (KVN) 21m radio telescopes from 2011 October to 2016 May for the northern hemisphere sources, and the Mopra 22m telescope in 2012 April for the southern hemisphere sources. See section 2.3 for further explanations. (8 data files).

  3. The prevalence of musculoskeletal disorders and occupational risk factors in Kashan SAIPA automobile industry workers by key indicator method (KIM), 1390

    National Research Council Canada - National Science Library

    2012-01-01

    ... City’s Saipa automobile industry in 2011. .Material and Method: This study is a descriptive-cross sectional study conducted among workers with manual material handling 37 activities and 84 work duties...

  4. Evaluation of ephedrine, pseudoephedrine and phenylpropanolamine concentrations in human urine samples and a comparison of the specificity of DRI amphetamines and Abuscreen online (KIMS) amphetamines screening immunoassays.

    Science.gov (United States)

    Stout, Peter R; Klette, Kevin L; Horn, Carl K

    2004-01-01

    The purpose of this study was to evaluate the ability of two amphetamine class screening reagents to exclude ephedrine (EPH), pseudoephedrine (PSEPH), and phenylpropanolamine (PPA) from falsely producing positive immunoassay screening results. The study also sought to characterize the prevalence and concentration distributions of EPH, PSEPH, and PPA in samples that produced positive amphetamine screening results. Approximately 27,400 randomly collected human urine samples from Navy and Marine Corps members were simultaneously screened for amphetamines using the DRI and Abuscreen online immunoassays at a cutoff concentration of 500 ng/mL. All samples that screened positive were confirmed for amphetamine (AMP), methamphetamine (MTH), 3,4-Methylenedioxyamphetamine (MDA), 3,4-Methylenedioxymethamphetamine (MDMA), EPH, PSEPH, and PPA by gas chromatography/mass spectrometry (GC/MS). The DRI AMP immunoassay identified 1,104 presumptive amphetamine positive samples, of which only 1.99% confirmed positive for the presence of AMP, MTH, MDA, or MDMA. In contrast, the online AMP reagent identified 317 presumptive amphetamine positives with a confirmation rate for AMP, MTH, MDA, or MDMA of 7.94%. The presence of EPH, PSEPH, or PPA was confirmed in 833 of the 1,104 samples that failed to confirm positive for AMP, MTH, MDA, or MDMA; all of the 833 samples contained PSEPH. When compared to the entire screened sample set, PSEPH was present in approximately 3%, EPH in 0.9%, and PPA in 0.8% of the samples. The results indicate that cross reactivities for EPH, PSEPH, and PPA are greater than reported by the manufacturer of these reagents. The distribution of concentrations indicates that very large concentrations of EPH, PSEPH, and PPA are common.

  5. RAZLIKE U NEKIM MOTORIČKIM SPOSOBNOSTIMA KOD UČENIKA OBUHVAĆENIM NASTAVNIM I VANNASTAVNIM AKTIVNOSTIMA IZ KOŠARKE

    Directory of Open Access Journals (Sweden)

    Miodrag Kocić

    2005-05-01

    Full Text Available The aim of this research was to determine the effects that the third class of physical education during one term had on the mobility of the students tested. 101 students, who were divided into two groups, took part in the research. The first group, which was the control group, was made up of 50 students and the second group was made up of the remaining 51 students who were members of the basketball section. The system for measuring mobility encompassed six different disciplines: the high jump, 20 meters high start race, pull-ups, press-ups, forward bend (and lifting the upper part of the body on the bench. All the results of the research were processed in a usual way giving the information on central and dispersion statistics for all disciplines. The differences between the groups were determined by discriminative analysis

  6. Review of the role of government in East Asian economic development, Clarendon Press, Oxford, 1997, Aoki, Kim and Okuno - Fujiwara (editors)

    OpenAIRE

    Singh, Ajit

    1998-01-01

    This is an important and ambitious book but its timing could not be more unfortunate. It is the result of a two year research project co-sponsored by the Economic Development Institute (EDI) at the World Bank and by the Center for Economic Policy Research at Stanford University. The contributors who are based in the US, Japan, Korea and Malaysia are all leading experts in the subject. The book was apparently completed in October 1995; it therefore predates the current acute economic and finan...

  7. First experience under the exemption regime of EC Regulation 1228/2003 on Conditions for Access to the Network of Cross-Border Exchanges in Electricity / Kim Talus

    Index Scriptorium Estoniae

    Talus, Kim

    2005-01-01

    23. aprillil 2005 Euroopa Komisjoni poolt vastu võetud otsusest anda roheline tuli Estlink'i projektile, mis tähendab koostööd Eesti ja Soome elektrivõrkude vahel ; Euroopa Komisjon võttis aluseks regulatsiooni nr. 1228/2003 artikli 7

  8. Myungshin Im, Won-Kee Park, Changsu Choi, Yiseul Jeon, Ji-Hoon Kim (CEOU/SNU), Giseon Baek, Young-Seok Oh, Soojong Pak (Kyunghee Univ.)

    Science.gov (United States)

    Im, Myungshin; Park, Won-Kee; Choi, Changsu; Jeon, Yiseul; Kim, Ji-Hoon; Baek, Giseon; Oh, Young-Seok; Pak, Soojong

    2011-08-01

    On August 30 02:05 UT, we started observations of SN2011fe=PTF11kly (ATel#3581) in grizY and is/iz-bands using CQUEAN on the 2.1m telescope at McDonald observatory, and in zYJHK-bands using UKIRT. SN2011fe is found to have J~11.58 and K~11.55 mag (error~0.05 mag), still brightening in NIR with respect to ATel#3605.

  9. Tipovi kapitalizma, ekspanzija neoliberalizma i socijalni učinci u baltičkim zemljama, Sloveniji i Hrvatskoj: komparativni pristup

    OpenAIRE

    Lučev, Josip; Babić, Zdenko

    2013-01-01

    Europa je u posljednjih 40 godina doživjela »okretanje« tržištu na dvije razine. Prva je globalna »migratorna tehnologija« neoliberalizma koja se razvija od 1970-ih. Druga je tranzicija u središnjoj i istočnoj Europi u posljednjih dvadesetak godina. Mogu li se prepoznati alternativni razvojni putovi i modeli unutar zajedničke orijentacije tržištu i tržišnoj ekonomiji u Europi? Autori najprije ispituju fenomen neoliberalizma te se bave razmjerom u kojem su neoliberalne reforme primijenjene u p...

  10. Final Report: Letter to Mr. Kim Abbott, DOE-OAK Cal/EPA-UC Berkeley Bioremediation Reference Laboratory, Report, September 15, 1996 - November 1, 1998

    Energy Technology Data Exchange (ETDEWEB)

    Fuhs, G. Wolfgang

    1999-03-15

    Letter-format report to Project Officer summarizing information on the establishment at the University of California Berkeley campus of a Bioremediation Reference Laboratory to provide independent reference services and testing as needed to assist the California Environmental Protection Agency in the evaluation of bioremediation technologies submitted for the certification/ verification of performance claims under California statute. The project resulted in the establishment of a technical capability not otherwise available to the Agency.

  11. U traganju za povijesnim, kulturnim i umjetničkim identitetom umjetnika Schiavona: crtice iz povijesti njihove recepcije u 16. i 17. stoljeću

    Directory of Open Access Journals (Sweden)

    Ivana Prijatelj Pavičić

    2014-12-01

    Full Text Available Autorica pokazuje kako su uz trojicu poznatih likovnih umjetnika Schiavona, Andreu Meldolu (Andriju Medulića, Nicolu dell'Arca i Julija Klovića, u historiografiji i književnosti XVI. i XVII. stoljeća bili povezivani neki od identitetskih stereotipa koji su se i inače tada u književnosti i historiografiji povezivali uz Slavene, Ilire, Dalmatince, Morlake i Hrvate. Primjerice, kvalifikativ „barbarski“ koji se u bolonjskoj historiografiji XVI. st. povezuje uz Nicolu dell'Arca, predstavlja jednu od takvih nekoć uvriježenih stereotipnih skjavonskih karakteristike. U prvom dijelu rada autorica se bavi interpretacijama hrvatskog i makedonskog identiteta (porijekla slavnoga minijaturiste Julija Klovića u XVI. st., u djelima Klovićevih suvremenika poput Giorgia Vasarija i Francisca de Holande, te tijekom XIX. i XX. st, u radovima Ivana Kukuljevića Sakcinskoga, Ivana Goluba i Milana Pelca. Posebna se pažnja posvećuje danas dominantnoj hipotezi da bi „makedonstvo“ Julija Klovića moglo biti izmišljeno s ciljem posvjedočenja njegove umjetničke i rodne ukorijenjenosti u antičko tlo. U drugom se dijelu obrađuju zapisi o Andrei Meldoli i Nicoli dell'Arca u djelima talijanskih historiografa Girolama Borsellija, Cherubina Cherardaccija, Carla Ridolfija i Marca Boschinija, koji su pokušavali stilske specifičnosti kod ove dvojice umjetnika tumačiti kao posljedicu njihovog genotipa i fenotipa. Autorica se posebice osvrće na pojavu ideologema o barbarskom karakteru Nicole dell'Arca u zapisima Girolama Borsellija (kraj XV. st. i Cherubina Cherardaccija (XVI. st..

  12. First experience under the exemption regime of EC Regulation 1228/2003 on Conditions for Access to the Network of Cross-Border Exchanges in Electricity / Kim Talus

    Index Scriptorium Estoniae

    Talus, Kim

    2005-01-01

    23. aprillil 2005 Euroopa Komisjoni poolt vastu võetud otsusest anda roheline tuli Estlink'i projektile, mis tähendab koostööd Eesti ja Soome elektrivõrkude vahel ; Euroopa Komisjon võttis aluseks regulatsiooni nr. 1228/2003 artikli 7

  13. Marine Nutraceuticals: Prospects and Perspectives. By Se-Kwon Kim, CRC Press, 2013; 464 Pages. Price £108.00, ISBN 978-1-4665-1351-8

    Directory of Open Access Journals (Sweden)

    Shu-Kun Lin

    2013-04-01

    Full Text Available The following paragraphs are reproduced from the publisher’s website [1]. There is a great deal of consumer interest in natural bioactive substances due to their health benefits. Offering the potential to provide valuable nutraceuticals and functional food ingredients, marine-derived compounds are an abundant source of nutritionally and pharmacologically active agents, with both chemical diversity and complexity. Functional ingredients derived from marine algae, invertebrates, vertebrates, and microorganisms can help fill the need for novel bioactives to treat chronic conditions such as cancer, microbial infections, and inflammatory processes.

  14. Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma

    Directory of Open Access Journals (Sweden)

    Kwak TW

    2015-04-01

    Full Text Available Tae Won Kwak,1,* Hee Jae Shin,2,* Young-Il Jeong,1 Myoung-Eun Han,3 Sae-Ock Oh,3 Hyun-Jung Kim,4 Do Hyung Kim,5 Dae Hwan Kang1 1Biomedical Research Institute, Pusan National University Hospital, Busan, 2Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Ansan, 3Department of Anatomy, School of Medicine, Pusan National University, Gyeongnam, 4Genewel Co Ltd. Gyeonggi-do, 5School of Medicine, Pusan National University, Yangsan, Gyeongnam, Republic of Korea *These authors contributed equally to this work Background: The aim of this study is to investigate the anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma. Methods: The anticancer activity of streptochlorin was evaluated in vitro in various cholangiocarcinoma cell lines for apoptosis, proliferation, invasiveness, and expression of various protein levels. A liver metastasis model was prepared by splenic injection of HuCC-T1 cholangiocarcinoma cells using a BALB/c nude mouse model to study the systemic antimetastatic efficacy of streptochlorin 5 mg/kg at 8 weeks. The antitumor efficacy of subcutaneously injected streptochlorin was also assessed using a solid tumor xenograft model of SNU478 cells for 22 days in the BALB/c nude mouse. Results: Streptochlorin inhibited growth and secretion of vascular endothelial growth factor by cholangiocarcinoma cells in a dose-dependent manner and induced apoptosis in vitro. In addition, streptochlorin effectively inhibited invasion and migration of cholangiocarcinoma cells. Secretion of vascular endothelial growth factor and activity of matrix metalloproteinase-9 in cholangiocarcinoma cells were also suppressed by treatment with streptochlorin. Streptochlorin effectively regulated metastasis of HuCC-T1 cells in a mouse model of liver metastasis. In a tumor xenograft study using SNU478 cells, streptochlorin significantly inhibited tumor growth without changes in body weight

  15. Factors associated with group bullying and psychopathology in elementary school students using child-welfare facilities

    Directory of Open Access Journals (Sweden)

    Kim JW

    2015-04-01

    Full Text Available Jun Won Kim,1,2 KounSeok Lee,3 Young Sik Lee,4 Doug Hyun Han,4 Kyung Joon Min,4 Sung Hwan Song,5 Ga Na Park,6 Ju Young Lee,1 Jae Ock Kim5 1Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, College of Medicine, Seoul National University, Seoul, South Korea; 2Department of Psychiatry, Graduate School, Chung-Ang University, Seoul, South Korea; 3Department of Psychiatry, Samsung Medical Center, Seoul, South Korea; 4Department of Psychiatry, Chung-Ang University, College of Medicine, Seoul, South Korea; 5Department of Psychiatry, Gongju National Hospital, Gongju, South Korea; 6Department of Special Education, Graduate School, Dankook University, Jukjeon, South Korea Purpose: Low socioeconomic status is an important risk factor for child psychiatric problems. Low socioeconomic status is also associated with psychiatric problems later in life. We investigated the effects of group bullying on clinical characteristics and psychopathology in elementary school students using child-welfare facilities.Methods: Three hundred and fifty-eight elementary school students using child-welfare facilities were recruited. The School Bullying Self Rating Questionnaire was used to assess group bullying. To evaluate related psychopathology, the Children’s Problem-Behavior Screening Questionnaire, the Children’s Depression Inventory, the Beck Anxiety Inventory, the Suicidal Ideation Questionnaire, Young’s Internet Addiction Scale, and Conners–Wells’ Adolescent Self-Report Scale were applied. Samples were classified according to school grade (lower or upper, and each group’s characteristics were compared as they related to bullying victims versus non-victims.Results: The prevalence rate of group bullying was 22% in the lower-grade group and 12% in the higher-grade group. Bullying victims in lower grades reported high somatization, depressive symptoms, Internet addiction, and attention deficit hyperactivity disorder tendencies, whereas

  16. Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process

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    Ha ES

    2015-08-01

    Full Text Available Eun-Sol Ha,1 Jeong-Soo Kim,2 In-hwan Baek,3 Jin-Wook Yoo,1 Yunjin Jung,1 Hyung Ryong Moon,1 Min-Soo Kim1 1College of Pharmacy, Pusan National University, 2Dong-A ST Co Ltd, Yongin, 3College of Pharmacy, Kyungsung University, Busan, South Korea Abstract: In the present study, solid dispersion nanoparticles with a hydrophilic polymer and surfactant were developed using the supercritical antisolvent (SAS process to improve the dissolution and oral absorption of megestrol acetate. The physicochemical properties of the megestrol acetate solid dispersion nanoparticles were characterized using scanning electron microscopy, differential scanning calorimetry, powder X-ray diffraction, and a particle-size analyzer. The dissolution and oral bioavailability of the nanoparticles were also evaluated in rats. The mean particle size of all solid dispersion nanoparticles that were prepared was <500 nm. Powder X-ray diffraction and differential scanning calorimetry measurements showed that megestrol acetate was present in an amorphous or molecular dispersion state within the solid dispersion nanoparticles. Hydroxypropylmethyl cellulose (HPMC solid dispersion nanoparticles significantly increased the maximum dissolution when compared with polyvinylpyrrolidone K30 solid dispersion nanoparticles. The extent and rate of dissolution of megestrol acetate increased after the addition of a surfactant into the HPMC solid dispersion nanoparticles. The most effective surfactant was Ryoto sugar ester L1695, followed by d-a-tocopheryl polyethylene glycol 1000 succinate. In this study, the solid dispersion nanoparticles with a drug:HPMC:Ryoto sugar ester L1695 ratio of 1:2:1 showed >95% rapid dissolution within 30 minutes, in addition to good oral bioavailability, with approximately 4.0- and 5.5-fold higher area under the curve (0–24 hours and maximum concentration, respectively, than raw megestrol acetate powder. These results suggest that the preparation of megestrol

  17. Association of serum ferritin levels with smoking and lung function in the Korean adult population: analysis of the fourth and fifth Korean National Health and Nutrition Examination Survey

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    Lee CH

    2016-11-01

    Full Text Available Chan Ho Lee, Eun Kyung Goag, Su Hwan Lee, Kyung Soo Chung, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Joo Han Song Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Institute of Chest Disease, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea Background: Iron-catalyzed oxidative stress contributes to lung injury after exposure to various toxins, including cigarette smoke. An oxidant/antioxidant imbalance is considered to play a critical role in the pathogenesis of COPD. Ferritin is a key protein in iron homeostasis, and its capacity to oxidize and sequester the metal preventing iron prooxidant activity implicates its possible role in the alteration of antioxidant imbalance. We investigated the relationship among cigarette smoking, lung function, and serum ferritin concentration in a large cohort representative of the Korean adult population. Materials and methods: Among 50,405 participants of the Korean National Health and Nutrition Examination Survey from 2010 to 2014, 15,239 adult subjects older than 40 years with serum ferritin levels and spirometric data were selected for this study. Results: The mean age was 56.5 years for men (43% and 56.9 years for women (57%. The prevalence of airway obstruction was 13.4%, which was significantly higher in men than in women, and increased in former or current smokers. The median levels of serum ferritin were highest in the airway obstruction group, followed by the restrictive pattern group, and lowest in the normal lung function group. The median ferritin levels were increased by smoking status and amounts in each spirometric subgroup. In multivariable regression analysis, serum ferritin was positively associated with forced expiratory volume in 1 second and forced expiratory volume in 1 second/forced vital capacity, whereas the smoking amount was negatively associated with the adjustment with age, sex, height

  18. Comparative study on solid self-nanoemulsifying drug delivery and solid dispersion system for enhanced solubility and bioavailability of ezetimibe

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    Rashid R

    2015-09-01

    Full Text Available Rehmana Rashid,1 Dong Wuk Kim,1 Abid Mehmood Yousaf,1 Omer Mustapha,1 Fakhar ud Din,1 Jong Hyuck Park,1 Chul Soon Yong,2 Yu-Kyoung Oh,3 Yu Seok Youn,4 Jong Oh Kim,2 Han-Gon Choi11College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, South Korea; 2College of Pharmacy, Yeungnam University, Gyeongsan, South Korea; 3College of Pharmacy, Seoul National University, Seoul, South Korea; 4School of Pharmacy, Sungkyunkwan University, Suwon, South KoreaBackground: The objective of this study was to compare the physicochemical characteristics, solubility, dissolution, and oral bioavailability of an ezetimibe-loaded solid self-nanoemulsifying drug delivery system (SNEDDS, surface modified solid dispersion (SMSD, and solvent evaporated solid dispersion (SESD to identify the best drug delivery system with the highest oral bioavailability.Methods: For the liquid SNEDDS formulation, Capryol 90, Cremophor EL, and Tween 80 were selected as the oil, surfactant, and cosurfactant, respectively. The nanoemulsion-forming region was sketched using a pseudoternary phase diagram on the basis of reduced emulsion size. The optimized liquid SNEDDS was converted to solid SNEDDS by spray drying with silicon dioxide. Furthermore, SMSDs were prepared using the spray drying technique with various amounts of hydroxypropylcellulose and Tween 80, optimized on the basis of their drug solubility. The SESD formulation was prepared with the same composition of optimized SMSD. The aqueous solubility, dissolution, physicochemical properties, and pharmacokinetics of all of the formulations were investigated and compared with the drug powder.Results: The drug existed in the crystalline form in SMSD, but was changed into an amorphous form in SNEDDS and SESD, giving particle sizes of approximately 24, 6, and 11 µm, respectively. All of these formulations significantly improved the aqueous solubility and dissolution in the order of solid

  19. Carbon nanotubes impregnated with subventricular zone neural progenitor cells promotes recovery from stroke

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    Moon SU

    2012-06-01

    Full Text Available Sung Ung Moon,1,* Jihee Kim,1,2,* Kiran Kumar Bokara,1,* Jong Youl Kim,1 Dongwoo Khang,3,4 Thomas J Webster,3,4 Jong Eun Lee1,21Department of Anatomy, 2Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea; 3School of Engineering, 4Department of Orthopedics, Brown University, Providence, RI, USA*These authors contributed equally to this workAbstract: The present in vivo study was conducted to evaluate whether hydrophilic (HL or hydrophobic (HP carbon nanotubes (CNTs impregnated with subventricular zone neural progenitor cells (SVZ NPCs could repair damaged neural tissue following stroke. For this purpose, stroke damaged rats were transplanted with HL CNT-SVZ NPCs, HP CNT-SVZ NPCs, or SVZ NPCs alone for 1, 3, 5, and 8 weeks. Results showed that the HP CNT-SVZ NPC transplants improved rat behavior and reduced infarct cyst volume and infarct cyst area compared with the experimental control and the HL CNT-SVZ NPC and SVZ NPCs alone groups. The transplantation groups showed an increase in the expression of nestin (cell stemness marker and proliferation which was evident with the increased number of doublecortin and bromodeoxyuridine double-stained immunopositive cells around the lesion site. But, these effects were more prominent in the HP CNT-SVZ NPC group compared with the other transplantation groups. The HP CNT-SVZ NPC and HL CNT-SVZ NPC transplants increased the number of microtubule-associated protein 2 (marker for neurons and decreased the number of glial fibrillary acidic protein (marker for astroglial cells positive cells within the injury epicenter. The majority of the transplanted HP CNT-SVZ NPCs collectively broadened around the ischemic injured region and the SVZ NPCs differentiated into mature neurons, attained the synapse morphology (TUJ1, synaptophysin, and decreased microglial activation (CD11b/c [OX-42]. For these reasons, this study provided the first evidence that CNTs can improve

  20. Toxicity of 100 nm zinc oxide nanoparticles: a report of 90-day repeated oral administration in Sprague Dawley rats

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    Kim YR

    2014-12-01

    Full Text Available Yu-Ri Kim,1,* Jong-Il Park,2,* Eun Jeong Lee,1 Sung Ha Park,3 Nak-won Seong,2 Jun-Ho Kim,2 Geon-Yong Kim,2 Eun-Ho Meang,2 Jeong-Sup Hong,2 Su-Hyon Kim,2 Sang-Bum Koh,2 Min-Seok Kim,2 Cheol-Su Kim,4 Soo-Ki Kim,4 Sang Wook Son,5 Young Rok Seo,6 Boo Hyon Kang,7 Beom Seok Han,8 Seong Soo A An,9 Hyo-In Yun,9 Meyoung-Kon Kim1 1Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, Korea; 2General Toxicology Team, Korea Testing and Research Institute, Seoul, Korea; 3Department of Biochemistry, University of Bath, Bath, UK; 4Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju-si, Gangwon, Korea; 5Department of Life Science, Institute of Environmental Medicine for Green Chemistry, Dongguk University, Seoul, Korea; 6Nonclinical Research Institute, Chemon Inc., Yongin, Gyeonggi, Korea; 7Toxicological Research Center, Hoseo University, Ansan, Chungnam, Korea; 8Department of Bionanotechnology, Gachon University, Seongnam, Gyeonggi, Korea; 9College of Veterinary Medicine, Chungnam National University, Daejon, Korea  *These authors contributed equally to this work Abstract: Nanoparticles (NPs are used commercially in health and fitness fields, but information about the toxicity and mechanisms underlying the toxic effects of NPs is still very limited. The aim of this study is to investigate the toxic effect(s of 100 nm negatively (ZnOAE100[-] or positively (ZnOAE100[+] charged zinc oxide (ZnO NPs administered by gavage in Sprague Dawley rats, to establish a no observed adverse effect level, and to identify target organ(s. After verification of the primary particle size, morphology, hydrodynamic size, and zeta potential of each test article, we performed a 90-day study according to Organisation for Economic Co-operation and Development test guideline 408. For the 90-day study, the high dose was set at 500 mg/kg and the middle and low doses were set at 125 mg/kg and 31.25 mg

  1. Novel electrosprayed nanospherules for enhanced aqueous solubility and oral bioavailability of poorly water-soluble fenofibrate

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    Yousaf AM

    2016-01-01

    Full Text Available Abid Mehmood Yousaf,1,2 Omer Mustapha,1 Dong Wuk Kim,1 Dong Shik Kim,1 Kyeong Soo Kim,1 Sung Giu Jin,1 Chul Soon Yong,3 Yu Seok Youn,4 Yu-Kyoung Oh,5 Jong Oh Kim,3 Han-Gon Choi1 1College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi, South Korea; 2Faculty of Pharmacy, University of Central Punjab, Johar, Lahore, Pakistan; 3College of Pharmacy, Yeungnam University, Gyongsan, North Gyeongsang, 4School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi, 5College of Pharmacy, Seoul National University, Seoul, South Korea Purpose: The purpose of the present research was to develop a novel electrosprayed nanospherule providing the most optimized aqueous solubility and oral bioavailability for poorly water-soluble fenofibrate.Methods: Numerous fenofibrate-loaded electrosprayed nanospherules were prepared with polyvinylpyrrolidone (PVP and Labrafil® M 2125 as carriers using the electrospray technique, and the effect of the carriers on drug solubility and solvation was assessed. The solid state characterization of an optimized formulation was conducted by scanning electron microscopy, powder X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopic analyses. Oral bioavailability in rats was also evaluated for the formulation of an optimized nanospherule in comparison with free drug and a conventional fenofibrate-loaded solid dispersion.Results: All of the electrosprayed nanospherule formulations had remarkably enhanced aqueous solubility and dissolution compared with free drug. Moreover, Labrafil M 2125, a surfactant, had a positive influence on the solubility and dissolution of the drug in the electrosprayed nanospherule. Increases were observed as the PVP/drug ratio increased to 4:1, but higher ratios gave no significant increases. In particular, an electrosprayed nanospherule composed of fenofibrate, PVP, and Labrafil M 2125 at the weight ratio of 1

  2. Three-dimensional culture and interaction of cancer cells and dendritic cells in an electrospun nano-submicron hybrid fibrous scaffold

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    Kim TE

    2016-03-01

    Full Text Available Tae-Eon Kim,1–3,* Chang Gun Kim,1–3,* Jin Soo Kim,4 Songwan Jin,4 Sik Yoon,5 Hae-Rahn Bae,6 Jeong-Hwa Kim,7,8 Young Hun Jeong,7,8 Jong-Young Kwak1–3 1Department of Pharmacology, School of Medicine, 2Department of Biomedical Sciences, The Graduate School, Ajou University, Suwon, South Korea; 3Immune Network Pioneer Research Center, Ajou University Medical Center, Suwon, South Korea; 4Department of Mechanical Engineering, Korea Polytechnic University, Gyeonggi, South Korea; 5Department of Anatomy, School of Medicine, Pusan National University, Yangsan, South Korea; 6Department of Physiology, College of Medicine, Dong-A University, Busan, South Korea; 7School of Mechanical Engineering, 8Department of Mechanical Engineering, Graduate School, Kyungpook National University, Daegu, South Korea *These authors contributed equally to this work Abstract: An artificial three-dimensional (3D culture system that mimics the tumor microenvironment in vitro is an essential tool for investigating the cross-talk between immune and cancer cells in tumors. In this study, we developed a 3D culture system using an electrospun poly(ε-caprolactone (PCL nanofibrous scaffold (NFS. A hybrid NFS containing an uninterrupted network of nano- and submicron-scale fibers (400 nm to 2 µm was generated by deposition onto a stainless steel mesh instead of an aluminum plate. The hybrid NFS contained multiplanar pores in a 3D structure. Surface-seeded mouse CT26 colon cancer cells and bone marrow-derived dendritic cells (BM-DCs were able to infiltrate the hybrid NFS within several hours. BM-DCs cultured on PCL nanofibers showed a baseline inactive form, and lipopolysaccharide (LPS-activated BM-DCs showed increased expression of CD86 and major histocompatibility complex Class II. Actin and phosphorylated FAK were enriched where unstimulated and LPS-stimulated BM-DCs contacted the fibers in the 3D hybrid NFS. When BM-DCs were cocultured with mitoxantrone-treated CT26 cells in

  3. Diminished autonomic neurocardiac function in patients with generalized anxiety disorder

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    Kim K

    2016-12-01

    Full Text Available Kyungwook Kim,1 Seul Lee,2 Jong-Hoon Kim1–3 1Gachon University School of Medicine, 2Department of Psychiatry, Gil Medical Center, Gachon University School of Medicine, Gachon University, 3Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea Background: Generalized anxiety disorder (GAD is a chronic and highly prevalent disorder that is characterized by a number of autonomic nervous system symptoms. The purpose of this study was to investigate the linear and nonlinear complexity measures of heart rate variability (HRV, measuring autonomic regulation, and to evaluate the relationship between HRV parameters and the severity of anxiety, in medication-free patients with GAD. Methods: Assessments of linear and nonlinear complexity measures of HRV were performed in 42 medication-free patients with GAD and 50 healthy control subjects. In addition, the severity of anxiety symptoms was assessed using the State-Trait Anxiety Inventory and Beck Anxiety Inventory. The values of the HRV measures of the groups were compared, and the correlations between the HRV measures and the severity of anxiety symptoms were assessed. Results: The GAD group showed significantly lower standard deviation of RR intervals and the square root of the mean squared differences of successive normal sinus intervals values compared to the control group (P<0.01. The approximate entropy value, which is a nonlinear complexity indicator, was also significantly lower in the patient group than in the control group (P<0.01. In correlation analysis, there were no significant correlations between HRV parameters and the severity of anxiety symptoms. Conclusion: The present study indicates that GAD is significantly associated with reduced HRV, suggesting that autonomic neurocardiac integrity is substantially impaired in patients with GAD. Future prospective studies are required to investigate the effects of pharmacological or non-pharmacological treatment on

  4. [The early medical textbooks in Korea: medical textbooks published at Je Joong Won-Severance Hospital Medical School].

    Science.gov (United States)

    Park, H W

    1998-01-01

    Kwang Hye Won(Je Joong Won), the first western hospital in Korea, was founded in 1885. The first western Medical School in Korea was open in 1886 under the hospital management. Dr. O. R. Avison, who came to Korea in 1893, resumed the medical education there, which was interrupted for some time before his arrival in Korea. He inaugurated translating and publishing medical textbooks with the help of Kim Pil Soon who later became one of the first seven graduates in Severance Hospital Medical School. The first western medical textbook translated into Korean was Henry Gray's Anatomy. However, these twice-translated manuscripts were never to be published on account of being lost and burnt down. The existing early anatomy textbooks, the editions of 1906 and 1909, are not the translation of Gray's Anatomy, but that of Japanese anatomy textbook of Gonda. The remaining oldest medical textbook in Korean is Inorganic Materia Medica published in 1905. This book is unique among its kind that O. R. Avison is the only translator of the book and it contains the prefaces of O. R. Avison and Kim Pil Soon. The publication of medical textbook was animated by the participation of other medical students, such as Hong Suk Hoo and Hong Jong Eun. The list of medical textbooks published includes almost all the field of medicine. The medical textbooks in actual existence are as follows: Inorganic Materia Medica (1905), Inorganic Chemistry (1906), Anatomy I (1906), Physiology (1906), Diagnostics I (1906), Diagnostics II (1907), Obstetrics (1908), Organic Chemistry (1909), Anatomy (1909), and Surgery (1910).

  5. Analysis of North Korea's Nuclear Tests under Prospect Theory

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Han Myung; Ryu, Jae Soo; Lee, Kwang Seok; Lee, Dong Hoon; Jun, Eunju; Kim, Mi Jin [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    North Korea has chosen nuclear weapons as the means to protect its sovereignty. Despite international society's endeavors and sanctions to encourage North Korea to abandon its nuclear ambition, North Korea has repeatedly conducted nuclear testing. In this paper, the reason for North Korea's addiction to a nuclear arsenal is addressed within the framework of cognitive psychology. The prospect theory addresses an epistemological approach usually overlooked in rational choice theories. It provides useful implications why North Korea, being under a crisis situation has thrown out a stable choice but taken on a risky one such as nuclear testing. Under the viewpoint of prospect theory, nuclear tests by North Korea can be understood as follows: The first nuclear test in 2006 is seen as a trial to escape from loss areas such as financial sanctions and regime threats; the second test in 2009 was interpreted as a consequence of the strategy to recover losses by making a direct confrontation against the United States; and the third test in 2013 was understood as an attempt to strengthen internal solidarity after Kim Jong-eun inherited the dynasty, as well as to enhance bargaining power against the United States. Thus, it can be summarized that Pyongyang repeated its nuclear tests to escape from a negative domain and to settle into a positive one. In addition, in the future, North Korea may not be willing to readily give up its nuclear capabilities to ensure the survival of its own regime.

  6. Iron oxide-based nanomagnets in nanomedicine: fabrication and applications

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    Meng Meng Lin

    2010-02-01

    Full Text Available Iron oxide-based nanomagnets have attracted a great deal of attention in nanomedicine over the past decade. Down to the nanoscale, superparamagnetic iron oxide nanoparticles can only be magnetized in the presence of an external magnetic field, which makes them capable of forming stable colloids in a physio-biological medium. Their superparamagnetic property, together with other intrinsic properties, such as low cytotoxicity, colloidal stability, and bioactive molecule conjugation capability, makes such nanomagnets ideal in both in-vitro and in-vivo biomedical applications. In this review, a chemical, physical, and biological synthetic approach to prepare iron oxide-based nanomagnets with different physicochemical properties was illustrated and compared. The growing interest in iron oxide-based nanomagnets with multifunctionalities was explored in cancer diagnostics and treatment, focusing on their combined roles in a magnetic resonance contrast agent, hyperthermia, and magnetic force assisted drug delivery. Iron oxides as magnetic carriers in gene therapy were reviewed with a focus on the sophisticated design and construction of magnetic vectors. Finally, the iron oxide-based nanomagnet also represents a very promising tool in particle/cell interfacing in controlling cellular functionalities, such as adhesion, proliferation, differentiation, and cell patterning, in stem cell therapy and tissue engineering applications. Meng Meng Lin received a BSc in biotechnology at the University of Hong Kong, China in 2004 and an MSc in biomedical nanotechnology at Newcastle University, UK, in 2005. She is currently working toward her PhD at the Institute of Science and Technology in Medicine, Keele University, UK. She was a visiting student at the Royal Institute of Technology, Sweden, in 2006. Her research interests include nanoparticles preparation, cell/nanomaterials interface, and cancer-oriented drug delivery. Hyung-Hwan Kim received an MSc degree in

  7. Optical imaging of absorption and distribution of RITC-SiO2 nanoparticles after oral administration

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    Lee CM

    2014-12-01

    Full Text Available Chang-Moon Lee,1 Tai Kyoung Lee,2–5 Dae-Ik Kim,1,6 Yu-Ri Kim,7 Meyoung-Kon Kim,7 Hwan-Jeong Jeong,2–5 Myung-Hee Sohn,2–5 Seok Tae Lim2–5 1Department of Biomedical Engineering, Chonnam National University, Yeosu, Jeollanam-Do, Republic of Korea; 2Department of Nuclear Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Jeollabuk-Do, Republic of Korea; 3Cyclotron Research Center, Chonbuk National University Medical School and Hospital, Jeonju, Jeollabuk-Do, Republic of Korea; 4Biomedical Research Institute, Chonbuk National University Medical School and Hospital, Jeonju, Jeollabuk-Do, Republic of Korea; 5Molecular Imaging and Therapeutic Medicine Research Center, Chonbuk National University Medical School and Hospital, Jeonju, Jeollabuk-Do, Republic of Korea; 6School of Electrical, Electronic Communication, and Computer Engineering, Chonnam National University, Yeosu, Jeollanam-Do, Republic of Korea; 7Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seounbuk-Gu, Seoul, Republic of Korea Purpose: In this study, we investigated the absorption and distribution of rhodamine B isothiocyanate (RITC-incorporated silica oxide nanoparticles(SiNPs (RITC-SiNPs after oral exposure, by conducting optical imaging, with a focus on tracking the movement of RITC-SiNPs of different particle size and surface charge. Methods: RITC-SiNPs (20 or 100 nm; positively or negatively charged were used to avoid the dissociation of a fluorescent dye from nanoparticles via spontaneous or enzyme-catalyzed reactions in vivo. The changes in the nanoparticle sizes and shapes were investigated in an HCl solution for 6 hours. RITC-SiNPs were orally administered to healthy nude mice at a dose of 100 mg/kg. Optical imaging studies were performed at 2, 4, and 6 hours after oral administration. The mice were sacrificed at 2, 4, 6, and 10 hours post-administration, and ex vivo imaging studies were performed

  8. Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers

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    Jang K

    2017-03-01

    Full Text Available Kyungho Jang,1,2,* Min-Kyoung Kim,3,4,* Jaeseong Oh,1 SeungHwan Lee,1 Joo-Youn Cho,1 Kyung-Sang Yu,1 Tai Kiu Choi,3 Sang-Hyuk Lee,3,4 Kyoung Soo Lim4 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, 2Center for Clinical Pharmacology and Biomedical Research Institute, Chonbuk National University Medical School, Jeonju, 3Department of Psychiatry, 4Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, Republic of Korea *These authors contributed equally to this work Purpose: Oseltamivir is widely used in the treatment and prophylaxis of influenza A and B viral infections. It is ingested as an oral prodrug that is rapidly metabolized by carboxylesterase 1 (CES1 to its active form, oseltamivir carboxylate. Dexamethasone is also used in the treatment of acute respiratory distress syndrome, a severe complication of influenza; however, its influence on the pharmacokinetics (PK of oseltamivir is controversial. The aim of this study was to investigate the effects of coadministering oseltamivir and dexamethasone on the PK of oseltamivir in healthy volunteers. Methods: An open-label, two-period, one-sequence, multiple-dose study was conducted in 19 healthy male volunteers. Oseltamivir (75 mg was orally administered on Day 1 and Day 8, and dexamethasone (1.5 mg was administered once daily from Day 3 to Day 8. Serial blood and urine samples were collected for PK analysis of oseltamivir and oseltamivir carboxylate on Day 1 and Day 8. Oseltamivir and oseltamivir carboxylate concentrations in plasma and urine were determined using liquid chromatography–tandem mass spectrometry. Results: Area under the plasma concentration–time curve (AUC of oseltamivir and oseltamivir carboxylate decreased after dexamethasone treatment for 6 days. The geometric mean ratio (90% confidence interval of the metabolic ratio

  9. Pharmacokinetic and pharmacodynamic interactions between metformin and a novel dipeptidyl peptidase-4 inhibitor, evogliptin, in healthy subjects

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    Rhee SJ

    2016-08-01

    Full Text Available Su-jin Rhee,1,* YoonJung Choi,1,* SeungHwan Lee,1,2 Jaeseong Oh,1 Sung-Jin Kim,3 Seo Hyun Yoon,1 Joo-Youn Cho,1 Kyung-Sang Yu1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea; 2Clinical Trials Center, Seoul National University Hospital, Seoul, Republic of Korea; 3Department of Clinical Development, Dong-A ST Co., Ltd., Seoul, Republic of Korea *These authors contributed equally to this work Abstract: Evogliptin is a newly developed dipeptidyl peptidase-4 (DPP-4 inhibitor, which is expected to be combined with metformin for treating type 2 diabetes mellitus. We investigated the potential pharmacokinetic and pharmacodynamic interactions between evogliptin and metformin. A randomized, open-label, multiple-dose, six-sequence, three-period crossover study was conducted in 36 healthy male subjects. All subjects received three treatments, separated by 7-day washout intervals: evogliptin, 5 mg od for 7 days (EVO; metformin IR, 1,000 mg bid for 7 days (MET; and the combination of EVO and MET (EVO + MET. After the last dose in a period, serial blood samples were collected for 24 hours for pharmacokinetic assessments. During steady state, serial blood samples were collected for 2 hours after an oral glucose tolerance test, and DPP-4, active glucagon-like peptide-1, glucose, glucagon, insulin, and C-peptide were measured to assess pharmacodynamic properties. EVO + MET and EVO showed similar steady state maximum concentration and area under the concentration–time curve at steady state values for evogliptin; the geometric mean ratios (90% confidence interval were 1.06 (1.01–1.12 and 1.02 (0.99–1.06, respectively. EVO + MET slightly reduced steady state maximum concentration and area under the concentration–time curve at steady state values for metformin compared to MET, with geometric mean ratios (90% confidence interval of 0.84 (0.79

  10. Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers

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    Yoon S

    2014-01-01

    Full Text Available Seonghae Yoon,1,* Howard Lee,2,* Tae-Eun Kim,1 SeungHwan Lee,1 Dong-Hyun Chee,3 Joo-Youn Cho,1 Kyung-Sang Yu,1 In-Jin Jang1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 2Clinical Trials Center, Seoul National University Hospital, 3AbbVie Ltd., Seoul, Republic of Korea *These authors contributed equally to this work Background: This study was conducted to compare the oral bioavailability of an itopride extended-release (ER formulation with that of the reference immediate-release (IR formulation in the fasting state. The effect of food on the bioavailability of itopride ER was also assessed. Methods: A single-center, open-label, randomized, multiple-dose, three-treatment, three-sequence, crossover study was performed in 24 healthy male subjects, aged 22–48 years, who randomly received one of the following treatments for 4 days in each period: itopride 150 mg ER once daily under fasting or fed conditions, or itopride 50 mg IR three times daily in the fasting state. Steady-state pharmacokinetic parameters of itopride, including peak plasma concentration (Cmax and area under the plasma concentration versus time curve over 24 hours after dosing (AUC0–24h, were determined by noncompartmental analysis. The geometric mean ratio of the pharmacokinetic parameters was derived using an analysis of variance model. Results: A total of 24 healthy Korean subjects participated, 23 of whom completed the study. The geometric mean ratio and its 90% confidence interval of once-daily ER itopride versus IR itopride three times a day for AUC0–24h were contained within the conventional bioequivalence range of 0.80–1.25 (0.94 [0.88–1.01], although Cmax was reached more slowly and was lower for itopride ER than for the IR formulation. Food delayed the time taken to reach Cmax for itopride ER, but AUC0–24h was not affected. There were no serious adverse events and both formulations were

  11. Hand grip strength and chronic obstructive pulmonary disease in Korea: an analysis in KNHANES VI

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    Lee SH

    2017-08-01

    Full Text Available Su Hwan Lee, Soo Jung Kim, Yeji Han, Yon Ju Ryu, Jin Hwa Lee, Jung Hyun Chang Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ewha Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Korea Background: Muscle mass is known to be associated with mortality in elderly adults. Because hand grip strength (HGS is known as a simple assessment tool for muscular strength, many researchers have studied the association between HGS and disease. However, empirical evidence for the relationship between chronic obstructive pulmonary disease (COPD and HGS is still controversial. The aim of this study was to evaluate the association between COPD and HGS, using Korean population data. Methods: This was a population-based cross-sectional study. Data were obtained from the sixth Korean National Health and Nutrition Examination Survey, which was conducted from 2013 to 2015. To reduce the effects of HGS-related factors and potential confounding factors, propensity score matching was used to match subjects with and without COPD. Results: Among 14,930 subjects, 832 were enrolled in each group (non-COPD and COPD after propensity score matching. COPD subjects did not have lower HGS than non-COPD subjects (non-COPD vs COPD, male, 38.0±7.0 vs 38.9±7.0 kg, P=0.044, female, 23.8±4.6 vs 24.2±4.9 kg, P=0.342. Lung function was classified by Global Initiative for Chronic Obstructive Lung Disease stages and was not significantly associated with HGS. For male COPD subjects, there was a significant correlation between HGS and the EuroQol Five-Dimension Questionnaire (EQ5D utility score index, which is an indicator of quality of life that adjusts for age and body mass index (r=0.201, P<0.001. The correlation was absent for female subjects (r=0.098, P=0.170. Conclusion: COPD subjects did not have lower HGS than non-COPD subjects. HGS did not associate with lung function. However, the HGS of male COPD subjects was

  12. Nanoparticulated docetaxel exerts enhanced anticancer efficacy and overcomes existing limitations of traditional drugs

    Directory of Open Access Journals (Sweden)

    Choi J

    2015-09-01

    Full Text Available Jinhyang Choi,1,2 Eunjung Ko,1 Hye-Kyung Chung,3 Jae Hee Lee,1 Eun Jin Ju,1 Hyun Kyung Lim,4 Intae Park,1 Kab-Sig Kim,5 Joo-Hwan Lee,5 Woo-Chan Son,6 Jung Shin Lee,1,7 Joohee Jung,1,4 Seong-Yun Jeong,1,2 Si Yeol Song,1,8 Eun Kyung Choi1,3,8 1Institute for Innovative Cancer Research, 2Asan Institute for Life Sciences, 3Center for Development and Commercialization of Anti-cancer Therapeutics, 4College of Pharmacy, Duksung Women’s University, 5Bio-Synectics, 6Department of Pathology, 7Department of Internal Medicine, 8Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea Abstract: Nanoparticulation of insoluble drugs improves dissolution rate, resulting in increased bioavailability that leads to increased stability, better efficacy, and reduced toxicity of drugs. Docetaxel (DTX, under the trade name Taxotere™, is one of the representative anticancer chemotherapeutic agents of this era. However, this highly lipophilic and insoluble drug has many adverse effects. Our novel and widely applicable nanoparticulation using fat and supercritical fluid (NUFS™ technology enabled successful nanoscale particulation of DTX (Nufs-DTX. Nufs-DTX showed enhanced dissolution rate and increased aqueous stability in water. After confirming the preserved mechanism of action of DTX, which targets microtubules, we showed that Nufs-DTX exhibited similar effects in proliferation and clonogenic assays using A549 cells. Interestingly, we observed that Nufs-DTX had a greater in vivo tumor growth delay effect on an A549 xenograft model than Taxotere™, which was in agreement with the improved drug accumulation in tumors according to the biodistribution result, and was caused by the enhanced permeability and retention (EPR effect. Although both Nufs-DTX and Taxotere™ showed negative results for our administration dose in the hematologic toxicity test, Nufs-DTX showed much less toxicity than Taxotere™ in

  13. Characteristics and Enlightenment of the Korean National Development after World WarⅡ%二战后朝鲜国家发展道路的特点与启示

    Institute of Scientific and Technical Information of China (English)

    高晴

    2013-01-01

    The Road North Korea's national development after World War II has its distinctive charactristic. Experience Kim Il-Sung, Kim Jong Il era era, Kim Jeong-eun era,North Korea developed its unique way of of its own. After the Korean War, the situation of workers and peasants "a thousand things wait to be done and the policy of"Military-first politics" make Korea difficult development. "Military-first politics"Triggered a multi-game issue, North Korea establishing a multilateral diplomacy breakthrough sanctions and blockade ofAmerican diplomatic and participate in regional cooperation. Information control of Korea Labor Party tight make Korea becomes the world's most secretive countries. These characteristics have strong two-way inspiration and reference for the political development of developing countries. Especially In the background of United States return to the Asia-Pacific strategic context, North Korea to should be concerned.%二战后朝鲜的国家发展道路有其鲜明的特点,经历金日成时代、金正日时代、金正恩时代,朝鲜以其独特的方式发展自身、走向世界。朝鲜战争后,百废待兴的局面和“工农为先”的政策使朝鲜艰难发展;“先军政治”---更是引发了朝核问题的多方博弈,外交领域朝鲜突破美国的制裁和封锁,建立多边外交、参加区域合作;朝鲜劳动党严密的信息控制使朝鲜成为世界上最神秘的国家。这些特点对于发展中国家的政治发展道路具有较强的双向的启示和借鉴作用。尤其在美国重返亚太的战略背景下,朝鲜的走向值得关注。

  14. Short- and long-term outcomes of laparoscopic surgery vs open surgery for transverse colon cancer: a retrospective multicenter study

    Directory of Open Access Journals (Sweden)

    Kim JW

    2016-04-01

    Full Text Available Jong Wan Kim,1 Jeong Yeon Kim,1 Byung Mo Kang,2 Bong Hwa Lee,3 Byung Chun Kim,4 Jun Ho Park5 1Department of Surgery, Dongtan Sacred Heart Hospital, College of Medicine, Hallym University, Hwaseong Si, 2Department of Surgery, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon Si, 3Department of Surgery, Hallym Sacred Heart Hospital, College of Medicine, Hallym University, Anyang Si, 4Department of Surgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, 5Department of Surgery, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Republic of Korea Purpose: The purpose of the present study was to compare the perioperative and oncologic outcomes between laparoscopic surgery and open surgery for transverse colon cancer.Patients and methods: We conducted a retrospective review of patients who underwent surgery for transverse colon cancer at six Hallym University-affiliated hospitals between January 2005 and June 2015. The perioperative outcomes and oncologic outcomes were compared between laparoscopic and open surgery.Results: Of 226 patients with transverse colon cancer, 103 underwent laparoscopic surgery and 123 underwent open surgery. There were no differences in the patient characteristics between the two groups. Regarding perioperative outcomes, the operation time was significantly longer in the laparoscopic group than in the open group (267.3 vs 172.7 minutes, P<0.001, but the time to soft food intake (6.0 vs 6.6 days, P=0.036 and the postoperative hospital stay (13.7 vs 15.7 days, P=0.018 were shorter in the laparoscopic group. The number of harvested lymph nodes was lower in the laparoscopic group than in the open group (20.3 vs 24.3, P<0.001. The 5-year overall survival (90.8% vs 88.6%, P=0.540 and disease-free survival (86.1% vs 78.9%, P=0.201 rates were similar in both groups.Conclusion: The present study showed that laparoscopic surgery is associated

  15. Tissue distribution and excretion kinetics of orally administered silica nanoparticles in rats

    Directory of Open Access Journals (Sweden)

    Lee JA

    2014-12-01

    Full Text Available Jeong-A Lee,1 Mi-Kyung Kim,1 Hee-Jeong Paek,1 Yu-Ri Kim,2 Meyoung-Kon Kim,2 Jong-Kwon Lee,3 Jayoung Jeong,3 Soo-Jin Choi1 1Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea; 2Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, Republic of Korea; 3Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungchungbuk–do, Republic of Korea Purpose: The effects of particle size on the tissue distribution and excretion kinetics of silica nanoparticles and their biological fates were investigated following a single oral administration to male and female rats. Methods: Silica nanoparticles of two different sizes (20 nm and 100 nm were orally administered to male and female rats, respectively. Tissue distribution kinetics, excretion profiles, and fates in tissues were analyzed using elemental analysis and transmission electron microscopy. Results: The differently sized silica nanoparticles mainly distributed to kidneys and liver for 3 days post-administration and, to some extent, to lungs and spleen for 2 days post-administration, regardless of particle size or sex. Transmission electron microscopy and energy dispersive spectroscopy studies in tissues demonstrated almost intact particles in liver, but partially decomposed particles with an irregular morphology were found in kidneys, especially in rats that had been administered 20 nm nanoparticles. Size-dependent excretion kinetics were apparent and the smaller 20 nm particles were found to be more rapidly eliminated than the larger 100 nm particles. Elimination profiles showed 7%–8% of silica nanoparticles were excreted via urine, but most nanoparticles were excreted via feces, regardless of particle size or sex. Conclusion: The kidneys, liver, lungs, and spleen were found to be the target organs of orally-administered silica nanoparticles in rats, and this organ

  16. PLGA nanofiber membranes loaded with epigallocatechin-3-O-gallate are beneficial to prevention of postsurgical adhesions

    Directory of Open Access Journals (Sweden)

    Shin YC

    2014-08-01

    Full Text Available Yong Cheol Shin,1,* Won Jun Yang,1,* Jong Ho Lee,1 Jin-Woo Oh,2 Tai Wan Kim,3 Jong-Chul Park,4 Suong-Hyu Hyon,5 Dong-Wook Han1 1Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, Republic of Korea; 2Department of Nanomaterials Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan, Republic of Korea; 3Department of Design, College of Arts, Pusan National University, Busan, Republic of Korea; 4Department of Medical Engineering, Yonsei University College of Medicine, Seoul, Republic of Korea; 5Center for Fiber and Textile Science, Kyoto Institute of Technology, Kyoto, Japan *These authors contributed equally to this work Abstract: This study concentrates on the development of biodegradable nanofiber membranes with controlled drug release to ensure reduced tissue adhesion and accelerated healing. Nanofibers of poly(lactic-co-glycolic acid (PLGA loaded with epigallocatechin-3-O-gallate (EGCG, the most bioactive polyphenolic compound in green tea, were electrospun. The physicochemical and biomechanical properties of EGCG-releasing PLGA (E-PLGA nanofiber membranes were characterized by atomic force microscopy, EGCG release and degradation profiles, and tensile testing. In vitro antioxidant activity and hemocompatibility were evaluated by measuring scavenged reactive oxygen species levels and activated partial thromboplastin time, respectively. In vivo antiadhesion efficacy was examined on the rat peritonea with a surgical incision. The average fiber diameter of E-PLGA membranes was approximately 300–500 nm, which was almost similar to that of pure PLGA equivalents. E-PLGA membranes showed sustained EGCG release mediated by controlled diffusion and PLGA degradation over 28 days. EGCG did not adversely affect the tensile strength of PLGA membranes, whereas it significantly decreased the elastic modulus and increased the strain at break. E-PLGA membranes were significantly effective in

  17. A Wind Tunnel Investigation of Joined Wing Scissor Morphing

    Science.gov (United States)

    2006-06-01

    wing stalls when the rear wing stalls [23]. While this improves efficiency it also decreases the wetted area while maintaining the same lifting...Analysis and Optimization on Joined-Wing Configurations. Dir. Dong-Hwan Lee and P. C. Chen. Slide Program. Zona Technology. 2. Bagwill, Tracy L., and

  18. Modernizing the North Korean System: Objectives, Method, and Application

    Science.gov (United States)

    2008-01-01

    Eberstadt, The End of North Korea, 1999; Kongdan Oh and Ralph Hassig, North Korea Through the Looking Glass , 2000; Chol-Hwan Kang and Pierre Rigoulot...The Two Koreas: A Contemporary History, revised and updated ed., New York: Basic Books, 2002. Oh, Kongdan, and Ralph C. Hassig, North Korea Through the Looking Glass , Washington

  19. The Goal of Motivation in the Military. Soldier Satisfaction or Soldier Performance

    Science.gov (United States)

    1978-06-09

    the employee motivation phenomenon is at least keeping pace vith the growing complexity of modern hardware tehnology. Now a look at motivation. The term...situation. Or~a n tjonal BehAvior and hwan Perfpouice, 1968, 3., 253-68. Lawler, dward E. Job design and employee motivation . Pmemw l Psycholom, 1969

  20. Evidence based healthcare design : building a safer, healthier and more efficient hospital

    NARCIS (Netherlands)

    Hulshof, C.

    2014-01-01

    ONDERZOEKERS TNO Jan Maarten Schraagen (PL), Sjoerd de Hoogh, Jacomien de Jong, Layla Lebesque, Eliane Schreuder, Selmar Smit STUURGROEP Jutta Hinterleitner (BNA), Eric Huijten (BNA), Roelof Gortemaker (dJGA), Jeroen Mennink (TNO) DEELNEMENDE ARCHITECTENBUREAUS Atelier PRO , EGM Architecten, de Jong

  1. The Inventiveness of a tradition : Structural anthropology in the Netherlands from an outsider’s perspective

    NARCIS (Netherlands)

    Berger, Peter

    2009-01-01

    Leiden structural anthropology achieved international renown through the work of J. P. B. and P. E. de Josselin de Jong and their colleagues and students. In the 1980s, especially after the retirement of P E. de Josselin de Jong in 1988, it grew quiet around this school. This article investigates th

  2. Diffusion tensor imaging in the early phase of schizophrenia

    NARCIS (Netherlands)

    Peters, B.D.

    2010-01-01

    Bart Peters gebruikte diffusie-MRI, een relatief nieuwe beeldvormende techniek, om de witte stof in de hersenen te onderzoeken bij twee groepen: jonge schizofreniepatiënten die net een eerste psychose hebben doorgemaakt, en jonge patiënten met lichte psychotische symptomen. Van deze laatste groep he

  3. Scheiden van dieren = Weaning of animals

    NARCIS (Netherlands)

    Dixhoorn, van I.D.E.; Dierendonck, van M.; Eerdenburg, van F.; Leengoed, van L.; Leenstra, F.R.; Schoemakers, N.; Vinke, C.

    2011-01-01

    Scheiden van jonge dieren van hun ouder(s) kan welzijnsproblemen veroorzaken, als dat op een onjuiste leeftijd of op een onjuiste wijze gebeurt. In dit rapport stellen we criteria op voor het scheiden van jonge dieren van hun ouders en geven we een indicatie bij welke diersoorten in de huidige prakt

  4. Levensloopbegeleiding bij autisme:hoe komen van droom naar daad?

    NARCIS (Netherlands)

    Teunisse, Jan-Pieter

    2011-01-01

    Roos is negentien jaar jong en heeft autisme. Zoals elke jonge vrouw droomt ze over haar toekomst. Die dromen zijn niet veel anders dan de dromen van haar leeftijdsgenoten zonder autisme. Maar waar voor ieder van hen daarbij de dichtregel van Willem Elsschot opgaat: ‘Tussen droom en daad staan wett

  5. Onderzoek naar de samenstelling van fabriekskaas

    OpenAIRE

    Sledsens, A.M.J.; Veen, van der, H.B.; Herstel, H.

    1985-01-01

    Van de Consumentenbond werden 50 monsters fabriekskaas ontvangen, te weten 18 monsters jonge Goudse kaas, 21 monsters jong belegen Goudse kaas, 2 monsters Amsterdammerkaas, 1 monster Maasdammer kaas en 8 monsters kaas aangeduid als Kollumer, Maasdammer, Texelaar, Beerendshoeve, IJsselkaas of Leerdammer. De monsters werden onderzocht op het gehalte aan vocht, vet, zout, nitraat en (gedeeltelijk) natamycine.

  6. Second-generation Turkish immigrant families in the Netherlands : parenting and toddler behavior problems

    NARCIS (Netherlands)

    Yaman, Ayse

    2009-01-01

    Er is nog relatief weinig bekend over de opvoeding en de ontwikkeling van gedragsproblemen bij jonge kinderen in tweede-generatie Turkse gezinnen in Nederland. In deze studie werden ruim 150 tweede-generatie Turkse moeders met jonge kinderen thuis bezocht en werden zij gefilmd tijdens verschillende

  7. ‘The’ pathway towards the elite level in Dutch basketball : A multidimensional and longitudinal study on the development of talented youth basketball players

    NARCIS (Netherlands)

    te Wierike, Sanne Cornelia Maria

    2016-01-01

    Veel jonge talentvolle basketballers hebben één doel voor ogen; de top halen in hun sport. Hoe de ontwikkeling van jonge speler tot aan volwassen basketballer verloopt, is onderzocht in het promotieonderzoek van Sanne te Wierike. Dit onderzoek is uitgevoerd bij Bewegingswetenschappen (UMCG, Rijksuni

  8. ‘The’ pathway towards the elite level in Dutch basketball : A multidimensional and longitudinal study on the development of talented youth basketball players

    NARCIS (Netherlands)

    te Wierike, Sanne Cornelia Maria

    2016-01-01

    Veel jonge talentvolle basketballers hebben één doel voor ogen; de top halen in hun sport. Hoe de ontwikkeling van jonge speler tot aan volwassen basketballer verloopt, is onderzocht in het promotieonderzoek van Sanne te Wierike. Dit onderzoek is uitgevoerd bij Bewegingswetenschappen (UMCG, Rijksuni

  9. Review: Margaret A. Morrison, Eric Haley, Kim Bartel Sheehan & Ronal E. Taylor (2002. Using Qualitative Research in Advertising: Strategies, Techniques, and Applications / Shay Sayre (2001. Qualitative Methods for Marketplace Research

    Directory of Open Access Journals (Sweden)

    Susanne Friese

    2004-01-01

    Full Text Available The review discusses two books, both covering very similar contents and addressing more or less the same audience. The book by SAYRE is about the use of qualitative method in marketplace research in general and is aimed at marketing students and practitioners; the book by MORRISON, HALEY, SHEEHAN and TAYLOR focuses more specifically on one area of mar­keting, namely advertising research. MORRISON et al. provide the more practical perspective, a fact that is also reflected in the writing style of the book. It is stimulating to read, even for readers fa­miliar with qualitative methods. It provides insights from the perspective of advertising agency plan­ners and demonstrates how qualitative methods are applied in a commercial context. SAYRE, in comparison, provides more details and builds her book around five theoretical perspectives. It is writ­ten by an academic for a largely academic audi­ence, containing all the basics that one needs to know when embarking on a qualitative research project. It differs from other qualitative method books in that the various steps along the way are illustrated by examples from the field of marketing. The book will, therefore, resonate well with mar­ket­ing students. Nonetheless, both books can be recommended as text books for qualitative method courses in marketing—SAYRE's book for market­ing students in general, and MORRISON et al.'s book for students specializing in the field of adver­tising. When used in a course where students conduct a small scale research project on their own, both books need to be supplemented by further readings or teacher input. Specifically, the sections on qualitative data analysis are too thin in MORRISON et al. and too broad in SAYRE in order to be useful to students without further explanation and training. Nonetheless, the two books are the best I have seen so far when it comes to selecting a book to be used in a qualitative method course for marketing students. URN: urn:nbn:de:0114-fqs0401258

  10. Anmeldelse af Ulrik Rammeskow Bang-Pedersen, Lasse Højlund Christensen, Kim Sommer Jensen, Christian Jul Madsen & Andreas Kærsgaard Mylin: Rekonstruktion – teori og praksis (2011)

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2011-01-01

    Artiklen anmelder det nævnte værk, som i detaljer behandler lov nr. 718 af 25. juni 2010, der indførte regler i konkursloven, som muliggør rekonstruktion af både fysiske og juridiske personer med henblik på virksomhedsoverdragelse og tvangsakkord, og således at skyldneren ikke selv kan standse re...

  11. Oral vaccination with LcrV from Yersinia pestis KIM delivered by live attenuated Salmonella enterica serovar Typhimurium elicits a protective immune response against challenge with Yersinia pseudotuberculosis and Yersinia enterocolitica.

    Science.gov (United States)

    Branger, Christine G; Torres-Escobar, Ascención; Sun, Wei; Perry, Robert; Fetherston, Jacqueline; Roland, Kenneth L; Curtiss, Roy

    2009-08-27

    The use of live recombinant attenuated Salmonella vaccines (RASV) synthesizing Yersinia proteins is a promising approach for controlling infection by Yersinia species. In this study, we constructed attenuated Salmonella strains which synthesize a truncated form of LcrV, LcrV196 and evaluated the immune response and protective efficacy elicited by these strains in mice against two other major species of Yersinia: Yersinia pseudotuberculosis and Yersinia enterocolitica. Surprisingly, we found that the RASV strain alone was sufficient to afford nearly full protection against challenge with Y. pseudotuberculosis, indicating the likelihood that Salmonella produces immunogenic cross-protective antigens. In contrast, lcrV196 expression was required for protection against challenge with Y. enterocolitica strain 8081, but was not sufficient to achieve significant protection against challenge with Y. enterocolitica strain WA, which expressed a divergent form of lcrV. Nevertheless, we are encouraged by these findings to continue pursuing our long-term goal of developing a single vaccine to protect against all three human pathogenic species of Yersinia.

  12. Report on the KIMS-CNA Conference (2nd): The PLA Navy’s Build-Up and ROK-USN Cooperation, Held in Seoul, Korea on 20 November 2008

    Science.gov (United States)

    2009-02-01

    Pacific: the Southwest Asian Seas, with the Malacca and Lombok Straits among others and sea lanes of communication (SLOCs) passing the Spratly...to East or Southeast Asia. If these routes were no longer cheap or safe, ships would use other routes, such as the Straits of Lombok and Makassar...Malacca and Lombok /Makassar Straits in Southeast Asia are an especially heavily burdened area in which a comprehensive system does not yet exist to

  13. Respiratory syncytial virus-like nanoparticle vaccination induces long-term protection without pulmonary disease by modulating cytokines and T-cells partially through alveolar macrophages

    Directory of Open Access Journals (Sweden)

    Lee YT

    2015-07-01

    Full Text Available Young-Tae Lee,1,* Eun-Ju Ko,1,2,* Hye Suk Hwang,1,2 Jong Seok Lee,1,3 Ki-Hye Kim,1 Young-Man Kwon,1 Sang-Moo Kang1,2 1Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, 2Department of Biology, Georgia State University, Atlanta, GA, USA; 3National Institute of Biological Resources, Incheon, South Korea *These authors contributed equally to this work Abstract: The mechanisms of protection against respiratory syncytial virus (RSV are poorly understood. Virus-like nanoparticles expressing RSV glycoproteins (eg, a combination of fusion and glycoprotein virus-like nanoparticles [FG VLPs] have been suggested to be a promising RSV vaccine candidate. To understand the roles of alveolar macrophages (AMs in inducing long-term protection, mice that were 12 months earlier vaccinated with formalin-inactivated RSV (FI-RSV or FG VLPs were treated with clodronate liposome prior to RSV infection. FI-RSV immune mice with clodronate liposome treatment showed increases in eosinophils, plasmacytoid dendritic cells, interleukin (IL-4+ T-cell infiltration, proinflammatory cytokines, chemokines, and, in particular, mucus production upon RSV infection. In contrast to FI-RSV immune mice with severe pulmonary histopathology, FG VLP immune mice showed no overt sign of histopathology and significantly lower levels of eosinophils, T-cell infiltration, and inflammatory cytokines, but higher levels of interferon-γ, which are correlated with protection against RSV disease. FG VLP immune mice with depletion of AMs showed increases in inflammatory cytokines and chemokines, as well as eosinophils. The results in this study suggest that FG nanoparticle vaccination induces long-term protection against RSV and that AMs play a role in the RSV protection by modulating eosinophilia, mucus production, inflammatory cytokines, and T-cell infiltration. Keywords: alveolar macrophage, nanoparticle vaccine, VLP, FI-RSV, RSV disease

  14. Estimation of health state utilities in breast cancer

    Directory of Open Access Journals (Sweden)

    Kim SH

    2017-03-01

    Full Text Available Seon-Ha Kim,1 Min-Woo Jo,2 Minsu Ock,2 Hyeon-Jeong Lee,2 Jong-Won Lee3,4 1Department of Nursing, College of Nursing, Dankook University, Cheonan, 2Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, 3Department of Breast and Endocrine Surgery, Asan Medical Center, Seoul, 4Department of Surgery, University of Ulsan College of Medicine, Seoul, South Korea Purpose: The aim of this study is to determine the utility of breast cancer health states using the standard gamble (SG and visual analog scale (VAS methods in the Korean general population.Materials and methods: Eight hypothetical breast cancer health states were developed based on patient education material and previous publications. Data from 509 individuals from the Korean general population were used to evaluate breast cancer health states using the VAS and the SG methods, which were obtained via computer-assisted personal interviews. Mean utility values were calculated for each human papillomavirus (HPV-related health state.Results: The rank of health states was identical between two valuation methods. SG values were higher than VAS values in all health states. The utility values derived from SG were 0.801 (noninvasive breast cancer with mastectomy and followed by reconstruction, 0.790 (noninvasive breast cancer with mastectomy only, 0.779 (noninvasive breast cancer with breast-conserving surgery and radiation therapy, 0.731 (invasive breast cancer with surgery, radiation therapy, and/or chemotherapy, 0.610 (locally advanced breast cancer with radical mastectomy with radiation therapy, 0.587 (inoperable locally advanced breast cancer, 0.496 (loco-regional recurrent breast cancer, and 0.352 (metastatic breast cancer.Conclusion: Our findings might be useful for economic evaluation of breast cancer screening and interventions in general populations. Keywords: breast neoplasm, Korea, quality-adjusted life years, quality of life

  15. Complications and outcomes of surgery for degenerative lumbar deformity in elderly patients

    Directory of Open Access Journals (Sweden)

    Kim HJ

    2013-12-01

    Full Text Available Hyo Jong Kim, Kyu Yeol Lee, Lih WangDepartment of Orthopaedic Surgery, College of Medicine, Dong-A University, Busan, KoreaBackground: The purpose of this study was to analyze the complications, clinical outcomes, and any correlative risk factors associated with degenerative lumbar deformity surgery in elderly patients.Methods: We reviewed 78 patients who underwent posterior decompression and posterolateral fusion requiring a minimum three-level fusion for degenerative lumbar deformity associated with spinal stenosis between May 2001 and May 2006, with at least a one-year follow-up period. We assessed and compared the postoperative complications and clinical outcomes for patients aged 65 years and over (group A and patients aged 50–64 years (group B. Risk factors that could influence complications and clinical outcome were evaluated and statistically analyzed.Results: The postoperative complication rate was not significantly different between the two age groups (53% in group A and 40% in group B; however, group A had a significantly higher frequency of minor complications than group B, especially for urinary retention and postoperative delirium. A statistical relationship between diabetes mellitus and deep wound infection, one of the major complications of degenerative lumbar deformity surgery, was observed in both group A and group B. Male sex was a risk factor for urinary retention and long operative time, and abundant blood loss was a significant risk factor for postoperative delirium in group A.Conclusion: There were no significant differences in results for degenerative lumbar deformity surgery between patients older and younger than 65 years. However, diabetes mellitus showed a significant correlation with deep wound infection, which is one of the major complications of degenerative lumbar deformity surgery, and with urinary retention and postoperative delirium, which occurred frequently in patients aged older than 65 years

  16. Hydrogen adsorption strength and sites in the metal organic framework MOF5: Comparing experiment and model calculations

    Science.gov (United States)

    Mulder, F. M.; Dingemans, T. J.; Schimmel, H. G.; Ramirez-Cuesta, A. J.; Kearley, G. J.

    2008-07-01

    Hydrogen adsorption in porous, high surface area, and stable metal organic frameworks (MOF's) appears a novel route towards hydrogen storage materials [N.L. Rosi, J. Eckert, M. Eddaoudi, D.T. Vodak, J. Kim, M. O'Keeffe, O.M. Yaghi, Science 300 (2003) 1127; J.L.C. Rowsell, A.R. Millward, K. Sung Park, O.M. Yaghi, J. Am. Chem. Soc. 126 (2004) 5666; G. Ferey, M. Latroche, C. Serre, F. Millange, T. Loiseau, A. Percheron-Guegan, Chem. Commun. (2003) 2976; T. Loiseau, C. Serre, C. Huguenard, G. Fink, F. Taulelle, M. Henry, T. Bataille, G. Férey, Chem. Eur. J. 10 (2004) 1373]. A prerequisite for such materials is sufficient adsorption interaction strength for hydrogen adsorbed on the adsorption sites of the material because this facilitates successful operation under moderate temperature and pressure conditions. Here we report detailed information on the geometry of the hydrogen adsorption sites, based on the analysis of inelastic neutron spectroscopy (INS). The adsorption energies for the metal organic framework MOF5 equal about 800 K for part of the different sites, which is significantly higher than for nanoporous carbon materials (˜550 K) [H.G. Schimmel, G.J. Kearley, M.G. Nijkamp, C.T. Visser, K.P. de Jong, F.M. Mulder, Chem. Eur. J. 9 (2003) 4764], and is in agreement with what is found in first principles calculations [T. Sagara, J. Klassen, E. Ganz, J. Chem. Phys. 121 (2004) 12543; F.M. Mulder, T.J. Dingemans, M. Wagemaker, G.J. Kearley, Chem. Phys. 317 (2005) 113]. Assignments of the INS spectra is realized using comparison with independently published model calculations [F.M. Mulder, T.J. Dingemans, M. Wagemaker, G.J. Kearley, Chem. Phys. 317 (2005) 113] and structural data [T. Yildirim, M.R. Hartman, Phys. Rev. Lett. 95 (2005) 215504].

  17. Still at Odds: The Japanese Abduction Issue and North Korea’s Circumvention

    Directory of Open Access Journals (Sweden)

    Anthony DiFilippo

    2013-05-01

    Full Text Available Durante las décadas de 1970 y 1980, Corea del Norte, o tal y como se la conoce oficialmente, la República Democrática Popular de Corea (RDPC, secuestró a una serie de ciudadanos japoneses. Este asunto, hoy por hoy todavía sin resolver, se ha politizado enormemente en Japón, en particular desde que el difunto Kim Jong-Il admitiese al anterior primer ministro japonés, Junichiro Koizumi que efectivamente la RDPC había secuestrado ciudadanos japoneses durante la Guerra Fría. Pyongyang sin embargo lleva desde hace un tiempo manteniendo que el asunto relativo a los secuestros quedó resuelto hace varios años, a la par que insiste en que Japón ha de pedir disculpas a la RDPC por la colonización de la Península de Corea. Por su parte, Tokio se mantiene firme en lo que respecta a la necesidad de resolver el problema de los secuestros, subrayando que es uno de los principales problemas que se oponen a la normalización de las relaciones Japón-Corea del Norte. En gran medida por la fuerte relación de seguridad que liga a Japón con los Estados Unidos, y que en los últimos años se ha tenido que enfrentar al desafío múltiple de los lanzamientos de misiles balísticos y los ensayos nucleares, este artículo también trata la cambiante postura de Washington en relación con el asunto de los secuestros.

  18. Relationship between cognitive insight and subjective quality of life in outpatients with schizophrenia

    Directory of Open Access Journals (Sweden)

    Kim JH

    2015-08-01

    Full Text Available Jong-Hoon Kim,1 Seul Lee,1 Ah-Young Han,1 Kyungwook Kim,2 Jinyoung Lee1 1Neuroscience Research Institute, Department of Psychiatry, Gil Medical Center, Gachon University School of Medicine, Gachon University, Incheon, Republic of Korea; 2Department of Medicine, Gachon University School of Medicine, Gachon University, Incheon, Republic of Korea Background: The concept of cognitive insight refers to the cognitive processes involved in patients’ re-evaluation of their anomalous experiences and of their misinterpretations. The purpose of the present study was to examine the relationship between cognitive insight and subjective quality of life in patients with schizophrenia to further shed light on the nature of cognitive insight and its functional correlates in schizophrenia.Methods: Seventy-one stable outpatients with schizophrenia were evaluated for cognitive insight and subjective quality of life using the Beck Cognitive Insight Scale (BCIS and the Schizophrenia Quality of Life Scale Revision 4 (SQLS-R4. The symptoms of schizophrenia were also assessed. Pearson’s correlation analysis and partial correlation analysis that controlled for the severity of symptoms were performed to adjust for the possible effects of symptoms.Results: The self-reflectiveness subscale score of the BCIS had significant positive correlations with the SQLS-R4 psychosocial domain and total SQLS-R4 scores, indicating that the higher the level of cognitive insight, the lower the subjective quality of life. In partial correlation analysis controlling for symptoms, the BCIS self-reflectiveness subscale score still had a significant correlation with the SQLS-R4 psychosocial domain score. The correlation coefficient between the BCIS self-reflectiveness and total SQLS-R4 scores was reduced to a nonsignificant statistical tendency.Conclusion: The results of our study suggest that cognitive insight, particularly the level of self-reflectiveness, is negatively associated with

  19. Development of paclitaxel-loaded liposomal nanocarrier stabilized by triglyceride incorporation

    Directory of Open Access Journals (Sweden)

    Hong SS

    2016-09-01

    Full Text Available Soon-Seok Hong,1 Ju Yeon Choi,2 Jong Oh Kim,2 Mi-Kyung Lee,3 So Hee Kim,4 Soo-Jeong Lim1 1Department of Bioscience and Bioengineering, Sejong University, Seoul, 2College of Pharmacy, Yeungnam University, Gyeongsan, 3College of Pharmacy, Woosuk University, Wanju-gun, Jeollabuk-do, 4College of Pharmacy and Research Institute of Pharmaceutical Science and Technology, Ajou University, Suwon, Republic of Korea Abstract: Studies have highlighted the challenge of developing injectable liposomes as a paclitaxel (PTX carrier, a challenge attributable to the limitations in liposomal stability caused by PTX loading. Poor stability of PTX-loaded liposomes is caused by PTX-triggered aggregation or fusion of liposomal membranes and is exacerbated in the presence of PEGylated lipid. In the present study, the effect of triglyceride incorporation on the stability of PTX-loaded/PEGylated liposomes was explored. Incorporation of a medium chain triglyceride Captex 300 into saturated phosphatidylcholine (PC-based liposomes (1,2-dimyristoyl-sn-glycero-3-phosphocholine [DMPC]:cholesterol [CHOL]:N-(Carbonyl-methoxypolyethyleneglycol 2000-1, 2-distearoyl-sn-glycero-3-phospho-ethanolamine [PE-PEG], produced a fine, homogeneous, and membrane-filterable PTX-loaded liposomes fulfilling the requirement of an injectable lipid formulation. Triglyceride incorporation also greatly inhibited the time-dependent leakage of PTX from saturated PC-based liposomes, which appears to be mediated by the inhibition of liposome fusion. In contrast, triglyceride incorporation induced the destabilization and PTX leakage of unsaturated PC-based liposomes, indicating the opposite effect of triglyceride depending on the fluidity status of PC constituting the liposomal membrane. PTX release profile and the in vitro and in vivo anticancer efficacy of triglyceride-incorporated DMPC:CHOL:PE-PEG liposomes were similar to Taxol® while the toxicity of liposomal PTX was significantly lower than that of

  20. Regarding the influence of sex and aging on dry eye disease

    Directory of Open Access Journals (Sweden)

    Han SB

    2017-09-01

    Full Text Available Sang Beom HanDepartment of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, Republic of KoreaI read with great interest the article by Ahn et al1 entitled “Sex differences in the effect of aging on dry eye disease”, in which the authors revealed the sex differences in the effect of aging on dry eye disease (DED in Korean adult population. They also showed the differences in patterns of DED following ocular surgery according to sex.1 The large population-based cross-sectional study was undoubtfully well designed and conducted, and suggests that matching of age and sex is recommended in further researches on DED.1However, I would like to point out that there exist controversies regarding the effect of aging and sex on DED. Our previous study showed that age had no significant association with the prevalence of DED in adults of 65 years or older, while female sex was significantly related to increased prevalence of DED.2 By contrast, studies in the US demonstrated that prevalence of DED increased with aging both in male and female populations.3,4 Moreover, there are differences in pathophysiology of DED according to age. Although dysfunction of lacrimal and meibomian glands may play an important role in the pathogenesis of DED in the elderly, DED associated with visual display terminal use or contact lens wear is more common in young and middle-aged patients.5 Therefore, I believe these differences in the pathogenesis should be considered in the evaluation of the effects of sex and aging on DED.Authors' replyJong Ho Ahn,1 Yoon-Hyeong Choi,2 Hae Jung Paik,1 Mee Kum Kim,3 Won Ryang Wee,3 Dong Hyun Kim11Department of Ophthalmology, Gachon University Gil Medical Center, 2Department of Preventive Medicine, Gachon University College of Medicine, Incheon, 3Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South KoreaWe thank the author for taking a

  1. Effect-site concentration of remifentanil for preventing cough during emergence in elderly patients undergoing nasal surgery: a comparison with adult patients

    Directory of Open Access Journals (Sweden)

    Yoo JY

    2016-09-01

    Full Text Available Ji Young Yoo,1 Jong Yeop Kim,1 Hyun Jeong Kwak,2 Dong Chul Lee,2 Go Wun Kim,1 Sook Young Lee,1 Yun Jeong Chae1 1Department of Anaesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, 2Department of Anaesthesiology and Pain Medicine, Gachon University, Gil Medical Center, Incheon, Korea Purpose: Prevention of cough during emergence after nasal surgery is important for avoiding surgical site bleeding. We investigated the remifentanil effect-site concentration in 50% (EC50 of the elderly patients undergoing nasal surgery for smooth emergence without cough and compared it with that of adult patients.Methods: Twenty-two elderly (aged 65–80 years and 25 adult patients (aged 20–60 years with an American Society of Anesthesiologists physical status I/II undergoing nasal surgery were enrolled. Anesthesia was maintained with sevoflurane and remifentanil. Remifentanil EC50 and EC95 for preventing cough were determined using the modified Dixon’s up-and-down method and isotonic regression with bootstrapping approach. Recovery profiles were also recorded.Results: With Dixon’s up-and-down method, the EC50 of remifentanil in elderly patients (2.40±0.25 ng/mL was not significantly different from that of adults (2.33±0.30 ng/mL (P=0.687. With isotonic regression, the EC95 of remifentanil in elderly patients (3.32 [95% confidence interval: 3.06–3.38] ng/mL was not significantly different from that of adults (3.30 [95% confidence interval: 2.96–3.37] ng/mL. However, eye opening time (14.1±3.8 vs 12.0±2.9 seconds, extubation time (17.2±4.1 vs 14.0±3.0 seconds, and postanesthesia care unit duration (44.5±7.6 vs 38.7±3.4 minutes in elderly patients were significantly longer than those in adults (P<0.05.Conclusion: Remifentanil EC50 for preventing cough after nasal surgery with sevoflurane anesthesia did not differ between elderly and adult patients. However, delayed awakening and respiratory adverse events may warrant attention

  2. Sex differences in the effect of aging on dry eye disease

    Directory of Open Access Journals (Sweden)

    Ahn JH

    2017-08-01

    Full Text Available Jong Ho Ahn,1 Yoon-Hyeong Choi,2 Hae Jung Paik,1 Mee Kum Kim,3 Won Ryang Wee,3 Dong Hyun Kim1 1Department of Ophthalmology, Gachon University Gil Medical Center, 2Department of Preventive Medicine, Gachon University College of Medicine, Incheon, 3Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea Purpose: Aging is a major risk factor in dry eye disease (DED, and understanding sexual differences is very important in biomedical research. However, there is little information about sex differences in the effect of aging on DED. We investigated sex differences in the effect of aging and other risk factors for DED.Methods: This study included data of 16,824 adults from the Korea National Health and Nutrition Examination Survey (2010–2012, which is a population-based cross-sectional survey. DED was defined as the presence of frequent ocular dryness or a previous diagnosis by an ophthalmologist. Basic sociodemographic factors and previously known risk factors for DED were included in the analyses. Linear regression modeling and multivariate logistic regression modeling were used to compare the sex differences in the effect of risk factors for DED; we additionally performed tests for interactions between sex and other risk factors for DED in logistic regression models.Results: In our linear regression models, the prevalence of DED symptoms in men increased with age (R=0.311, P=0.012; however, there was no association between aging and DED in women (P>0.05. Multivariate logistic regression analyses showed that aging in men was not associated with DED (DED symptoms/diagnosis: odds ratio [OR] =1.01/1.04, each P>0.05, while aging in women was protectively associated with DED (DED symptoms/diagnosis: OR =0.94/0.91, P=0.011/0.003. Previous ocular surgery was significantly associated with DED in both men and women (men/women: OR =2.45/1.77 [DED symptoms] and 3.17/2.05 [DED diagnosis], each P<0.001. Tests for

  3. Sleep and cognitive problems in patients with attention-deficit hyperactivity disorder

    Directory of Open Access Journals (Sweden)

    Lee HK

    2014-09-01

    Full Text Available Hae Kook Lee, Jong-Hyun Jeong, Na-Young Kim, Min-hyeon Park, Tae-Won Kim, Ho-Jun Seo, Hyun-Kook Lim, Seung-Chul Hong, Jin-Hee Han Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea Objectives: Attention-deficit hyperactivity disorder (ADHD is characterized by inattentive and impulsive behavior. Many ADHD patients reportedly have cognitive dysfunction and sleep problems, including longer sleep latency, lower sleep efficiency, and shorter total sleep time. The purpose of this study was to examine neurocognitive functions and nocturnal sleep parameters in patients with ADHD, using a cognitive function test and actigraphy.Methods: Subjects included 37 male patients with ADHD and 32 controls (7–12 years of age. For each participant, we determined intelligence quotient (IQ and administered the Matching Familiar Figures Test (MFFT and 72-hour actigraphy. The relationships between sleep parameters and cognitive functions were assessed.Results: ADHD patients significantly differed from controls in several cognitive functions and sleep variables. In the MFFT, response error rate (P<0.001 and error counts (P=0.003 were significantly increased in ADHD patients compared with control children. MFFT response latency was significantly shorter in ADHD patients than in controls (P<0.001. In addition, sleep latency (P=0.01, wake after sleep onset (WASO (P<0.001, and fragmentation index (P<0.001 were evaluated by actigraphy and found to be significantly increased in patients with ADHD compared with controls. However, no significant differences in total sleep time or sleep efficiency were observed. WASO and response error rates were positively correlated in patients with ADHD (rho =0.52, P=0.012. Furthermore, fragmentation index sleep variables were significantly positively correlated with response error (rho =0.44, P=0.008 and response latency rates (rho =0.4, P=0.018 in the MFFT. Reaction error rate was significantly

  4. Dose-dependent effects of cisplatin on the severity of testicular injury in Sprague Dawley rats: reactive oxygen species and endoplasmic reticulum stress

    Directory of Open Access Journals (Sweden)

    Soni KK

    2016-12-01

    Full Text Available Kiran Kumar Soni,1 Hye Kyung Kim,2 Bo Ram Choi,1 Keshab Kumar Karna,1 Jae Hyung You,1 Jai Seong Cha,1 Yu Seob Shin,1 Sung Won Lee,3 Chul Young Kim,4 Jong Kwan Park1 1Department of Urology, Institute for Medical Sciences, Chonbuk National University Medical School – Biomedical Research and Institute and Clinical Trial Center for Medical Devices, Chonbuk National University Hospital, Jeonju, 2College of Pharmacy, Kyungsung University, Busan, 3Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University Medical School, Seoul, 4College of Pharmacy, Hanyang University, Ansan, Republic of Korea Abstract: Cisplatin (CIS is used in the treatment of cancer, but its nonspecific systemic actions lead to toxic effects on other parts of the body. This study investigated the severity of CIS toxicity by increasing its dose over a constant time period. Sprague Dawley rats were divided into five treatment groups and control group with CIS (2, 4, 6, 8, and 10 mg/kg administered intraperitoneally for 5 days. The body and organs were weighed, epididymal sperm was counted, and sperm motility and sperm apoptosis were evaluated. Blood samples were evaluated for complete blood count, reactive oxygen and nitrogen species, malondialdehyde levels, and total testosterone. The testicular tissue was examined for steroidogenic acute regulatory protein and endoplasmic reticulum stress protein. Epididymal sperm was collected for CatSper Western blot. The toxic effects of different doses of CIS on the testis and kidney were compared histologically. The weights of body, testis, epididymis, prostate, seminal vesicle, and kidney; sperm count; sperm motility; steroidogenic acute regulatory protein level; and epididymal sperm count were significantly lower in the CIS-treated groups than in the control group. In contrast, sperm apoptosis, plasma reactive oxygen and nitrogen species, and malondialdehyde, testosterone, red blood cell

  5. The effect of dexamethasone/cell-penetrating peptide nanoparticles on gene delivery for inner ear therapy

    Directory of Open Access Journals (Sweden)

    Yoon JY

    2016-11-01

    Full Text Available Ji Young Yoon,1 Keum-Jin Yang,2 Shi-Nae Park,3 Dong-Kee Kim,3 Jong-Duk Kim1 1Department of Chemical and Biomolecular Engineering, BK 21 Plus Program, Korea Advanced Institute of Science and Technology, Guseong-Dong, Yuseong-Gu, Daejeon, 2Clinical Research Institute, St Mary’s Hospital, Daejeon, 3Department of Otolaryngology – Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea Abstract: Dexamethasone (Dex-loaded PHEA-g-C18-Arg8 (PCA nanoparticles (PCA/Dex were developed for the delivery of genes to determine the synergistic effect of Dex on gene expression. The cationic PCA nanoparticles were self-assembled to create cationic micelles containing an octadecylamine (C18 core with Dex and an arginine 8 (Arg8 peptide shell for electrostatic complexation with nucleic acids (connexin 26 [Cx26] siRNA, green fluorescent protein [GFP] DNA or brain-derived neurotrophic factor [BDNF] pDNA. The PCA/Dex nanoparticles conjugated with Arg8, a cell-penetrating peptide that enhances permeability through a round window membrane in the inner ear for gene delivery, exhibited high uptake efficiency in HEI-OC1 cells. This potential carrier co-delivering Dex and the gene into inner ear cells has a diameter of 120–140 nm and a zeta potential of 20–25 mV. Different types of genes were complexed with the Dex-loaded PCA nanoparticle (PCA/Dex/gene for gene expression to induce additional anti-inflammatory effects. PCA/Dex showed mildly increased expression of GFP and lower mRNA expression of inflammatory cytokines (IL1b, IL12, and INFr than did Dex-free PCA nanoparticles and Lipofectamine® reagent in HEI-OC1 cells. In addition, after loading Cx26 siRNA onto the surface of PCA/Dex, Cx26 gene expression was downregulated according to real-time polymerase chain reaction for 24 h, compared with that using Lipofectamine reagent. After loading BDNF DNA into PCA/Dex, increased expression of BDNF was observed for 30

  6. A genetic screen of the mutations in the Korean patients with early-onset Alzheimer’s disease

    Directory of Open Access Journals (Sweden)

    An SS

    2016-12-01

    Full Text Available Seong Soo An,1,* Sun Ah Park,2,* Eva Bagyinszky,1 Sun Oh Bae,1 Yoon-Jeong Kim,2 Ji Young Im,2 Kyung Won Park,3 Kee Hyung Park,4 Eun-Joo Kim,5 Jee Hyang Jeong,6 Jong Hun Kim,7 Hyun Jeong Han,8 Seong Hye Choi,9 SangYun Kim10 1Department of Bionano Technology, Gachon University, Seongnam-si, 2Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, 3Department of Neurology, Dong-A University College of Medicine and Institute of Convergence Bio-Health, Busan, 4Department of Neurology, Gachon University Gil Medical Center, Incheon, 5Department of Neurology, Pusan National University Hospital, Busan, 6Department of Neurology, Ewha Womans University Mokdong Hospital, Seoul, 7Department of Neurology, Ilsan Hospital, National Health Insurance Corporation, 8Department of Neurology, Myongii Hospital, Goyang, 9Department of Neurology, Inha University School of Medicine, Incheon, 10Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea *These authors contributed equally to this work Abstract: Early-onset Alzheimer’s disease (EOAD has distinct clinical characteristics in comparison to late-onset Alzheimer’s disease (LOAD. The genetic contribution is suggested to be more potent in EOAD. However, the frequency of causative mutations in EOAD could be variable depending on studies. Moreover, no mutation screening study has been performed yet employing large population in Korea. Previously, we reported that the rate of family history of dementia in EOAD patients was 18.7% in a nationwide hospital-based cohort study, the Clinical Research Center for Dementia of South Korea (CREDOS study. This rate is much lower than in other countries and is even comparable to the frequency of LOAD patients in our country. To understand the genetic characteristics of EOAD in Korea, we screened the common Alzheimer’s disease (AD

  7. 78 FR 68151 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Science.gov (United States)

    2013-11-13

    ... PHILIP STEPHEN KELLER TOBIAS PETER KEUNG JANICE YUN YEE KIM DAN NAMHYUNG KIM JOHN HOON KIM JOONGI KIM KYUNG KEUN KIM YOUNG KEUN KINDSCHI NADIA KING KATHERINE......... CLARE CONSTANCE KING WILLIAM KIRCHHOFF TILMAN LEANDER KISSMANN EDNA KLAWITTER KLAUS MICHAEL KLEIN WENDY TARLETON KLOSTER STEPHEN CLAIR...

  8. Silymarin-loaded solid nanoparticles provide excellent hepatic protection: physicochemical characterization and in vivo evaluation

    Directory of Open Access Journals (Sweden)

    Yang KY

    2013-08-01

    Full Text Available Kwan Yeol Yang,1,* Du Hyeong Hwang,1,* Abid Mehmood Yousaf,2 Dong Wuk Kim,2 Young-Jun Shin,2 Ok-Nam Bae,2 Yong-II Kim,1 Jong Oh Kim,1 Chul Soon Yong,1 Han-Gon Choi2 1College of Pharmacy, Yeungnam University, Dae-Dong, Gyongsan, 2College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Sangnok-gu, Ansan, South Korea *These authors contributed equally to this work Background: The purpose of this study was to develop a novel silymarin-loaded solid nanoparticle system with enhanced oral bioavailability and an ability to provide excellent hepatic protection for poorly water-soluble drugs using Shirasu porous glass (SPG membrane emulsification and a spray-drying technique. Methods: A silymarin-loaded liquid nanoemulsion was formulated by applying the SPG membrane emulsification technique. This was further converted into solid state nanosized particles by the spray-drying technique. The physicochemical characteristics of these nanoparticles were determined by scanning electron microscopy, differential scanning calorimetry, and powder X-ray diffraction. Their dissolution, bioavailability, and hepatoprotective activity in rats were assessed by comparison with a commercially available silymarin-loaded product. Results: Formulation of a silymarin-loaded nanoemulsion, comprising silymarin, castor oil, polyvinylpyrrolidone, Transcutol HP, Tween 80, and water at a weight ratio of 5/3/3/1.25/1.25/100 was accomplished using an SPG membrane emulsification technique at an agitator speed of 700 rpm, a feed pressure of 15 kPa, and a continuous phase temperature of 25°C. This resulted in generation of comparatively uniform emulsion globules with a narrow size distribution. Moreover, the silymarin-loaded solid nanoparticles, containing silymarin/castor oil/polyvinylpyrrolidone/Transcutol HP/Tween 80 at a weight ratio of 5/3/3/1.25/1.25, improved about 1,300-fold drug solubility and retained a mean size of about 210 nm

  9. The fate of calcium carbonate nanoparticles administered by oral route: absorption and their interaction with biological matrices

    Directory of Open Access Journals (Sweden)

    Lee JA

    2015-03-01

    Full Text Available Jeong-A Lee,1,* Mi-Kyung Kim,1,* Hyoung-Mi Kim,2,* Jong Kwon Lee,3 Jayoung Jeong,4 Young-Rok Kim,5 Jae-Min Oh,2 Soo-Jin Choi1 1Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea; 2Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Wonju, Republic of Korea; 3Hazard Substances Analysis Division, Gwangju Regional Food and Drug Administration, Ministry of Food and Drug Safety, Gwangju, Republic of Korea; 4Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungcheongbuk-do, Republic of Korea; 5Department of Food Science and Biotechnology, Kyung Hee University, Yongin, Republic of Korea *These authors contributed equally to this work Background: Orally administered particles rapidly interact with biological fluids containing proteins, enzymes, electrolytes, and other biomolecules to eventually form particles covered by a corona, and this corona potentially affects particle uptake, fate, absorption, distribution, and elimination in vivo. This study explored relationships between the biological interactions of calcium carbonate particles and their biokinetics.Methods: We examined the effects of food grade calcium carbonates of different particle size (nano [N-Cal] and bulk [B-Cal]: specific surface areas of 15.8 and 0.83 m2/g, respectively on biological interactions in in vitro simulated physiological fluids, ex vivo biofluids, and in vivo in gastrointestinal fluid. Moreover, absorption and tissue distribution of calcium carbonates were evaluated following a single dose oral administration to rats.Results: N-Cal interacted more with biomatrices than bulk materials in vitro and ex vivo, as evidenced by high fluorescence quenching ratios, but it did not interact more actively with biomatrices in vivo. Analysis of coronas revealed that immunoglobulin, apolipoprotein, thrombin, and fibrinogen

  10. Organization of research team for nano-associated safety assessment in effort to study nanotoxicology of zinc oxide and silica nanoparticles

    Directory of Open Access Journals (Sweden)

    Kim YR

    2014-12-01

    Full Text Available Yu-Ri Kim,1,* Sung Ha Park,2,* Jong-Kwon Lee,3 Jayoung Jeong,3 Ja Hei Kim,4 Eun-Ho Meang,5 Tae Hyun Yoon,6 Seok Tae Lim,7 Jae-Min Oh,8 Seong Soo A An,9 Meyoung-Kon Kim1 1Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea; 2Department of Biochemistry, University of Bath, Bath, UK; 3Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungchungbuk-do, 4Consumers Korea, Chongro-ku, 5General toxicology team, Korea Testing and Research Institute, 6Laboratory of Nanoscale Characterization and Environmental Chemistry, Department of Chemistry, College of Natural Sciences, Hanyang University, Seoul, 7Department of Nuclear Medicine, Chonbuk National University Medical School, Jeonju, Jellabuk-Do, 8Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Gangwon-do, 9Department of Bionanotechnology, Gachon Medical Research Institute, Gachon University, Seongnam, South Korea *Authors contributed equally to this work Abstract: Currently, products made with nanomaterials are used widely, especially in biology, biotechnologies, and medical areas. However, limited investigations on potential toxicities of nanomaterials are available. Hence, diverse and systemic toxicological data with new methods for nanomaterials are needed. In order to investigate the nanotoxicology of nanoparticles (NPs, the Research Team for Nano-Associated Safety Assessment (RT-NASA was organized in three parts and launched. Each part focused on different contents of research directions: investigators in part I were responsible for the efficient management and international cooperation on nano-safety studies; investigators in part II performed the toxicity evaluations on target organs such as assessment of genotoxicity, immunotoxicity, or skin penetration; and investigators in part III evaluated the toxicokinetics of NPs with newly developed

  11. Efficacy and safety of fixed-dose combination therapy with olmesartan medoxomil and rosuvastatin in Korean patients with mild to moderate hypertension and dyslipidemia: an 8-week, multicenter, randomized, double-blind, factorial-design study (OLSTA-D RCT: OLmesartan rosuvaSTAtin from Daewoong

    Directory of Open Access Journals (Sweden)

    Park JS

    2016-08-01

    Full Text Available Jin-Sun Park,1,* Joon-Han Shin,1,* Taek-Jong Hong,2 Hong-Seog Seo,3 Wan-Joo Shim,4 Sang-Hong Baek,5 Jin-Ok Jeong,6 Youngkeun Ahn,7 Woong-Chol Kang,8 Young-Hak Kim,9 Sang-Hyun Kim,10 Min-Su Hyon,11 Dong-Hoon Choi,12 Chang-Wook Nam,13 Tae-Ho Park,14 Sang-Chol Lee,15 Hyo-Soo Kim16 1Department of Cardiology, Ajou University School of Medicine, Suwon, 2Division of Cardiology, Pusan National University Hospital, Busan, 3Division of Cardiology, Korea University Guro Hospital, Korea University College of Medicine, 4Division of Cardiology, Korea University Anam Hospital, 5Cardiovascular Division, Catholic University of Korea, Seoul St Mary’s Hospital, Seoul, 6Division of Cardiology, Chungnam National University Hospital, Daejeon, 7Division of Cardiology, Chonnam National University Hospital, Gwangju, 8Division of Cardiology, Gachon University Gil Hospital, Incheon, 9Division of Cardiology, Asan Medical Center, College of Medicine, University of Ulsan, 10Division of Cardiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, 11Division of Cardiology, Soonchunhyang University Hospital, 12Division of Cardiology, Yonsei University Severance Hospital, Seoul, 13Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, 14Division of Cardiology, Dong-A University Hospital, Busan, 15Cardiovascular Imaging Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 16Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, Korea *These authors contributed equally to this work Abstract: The pill burden of patients with hypertension and dyslipidemia can result in poor medication compliance. This study aimed to evaluate the efficacy and safety of fixed-dose combination (FDC therapy with olmesartan medoxomil (40 mg and rosuvastatin (20 mg in Korean patients with mild to moderate hypertension and dyslipidemia. This multicenter, randomized, double

  12. Traditsioonist ja uuendusest korea modernkunstis / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2005-01-01

    Souli galeriides ja muuseumides valitseb eeldatud kõrgtehnoloogilise kunsti asemel maalikunst. Pikemalt naiskunstnik Wook-kyung Choi (1940-1985) ja Jong-gu Lee näitustest ning soo- ja naisuuringute kongressist "Women's World 2005"

  13. Literatuuronderzoek naar gegevens betreffende de betekenis van een aantal verwekkers van zoonosen in verband met de vleesconsumptie. VI: Yersinia enterocolitica

    NARCIS (Netherlands)

    Bos; J.M.; Engel; H.W.B.; Groothuis; D.G.; Knapen; F.van; Oosterom; J.; Weiss; J.W.

    1985-01-01

    Yersinia enterocolitica kan bij de mens aanleiding geven tot verschillende ziektebeelden. Het meest wordt de acute enterocolitis beschreven, vooral bij zeer jonge kinderen, maar daarnaast zijn ook de acute mesenteriale lymfadenitis en terminale ileitis (pseudoappendicitis) bekend. Dragerschap zo

  14. Context based games for mobile learning

    NARCIS (Netherlands)

    Ternier, Stefaan; De Jong, Tim; Kelle, Sebastian

    2009-01-01

    Ternier, S., De Jong, T., & Kelle, S. (2009). Context based games for mobile learning. Presentation given at Symposium Mobile Learning in Context. September, 11, 2009, Heerlen, The Netherlands: Open University of the Netherlands.

  15. Context based games for mobile learning

    NARCIS (Netherlands)

    Ternier, Stefaan; De Jong, Tim; Kelle, Sebastian

    2009-01-01

    Ternier, S., De Jong, T., & Kelle, S. (2009). Context based games for mobile learning. Presentation given at Symposium Mobile Learning in Context. September, 11, 2009, Heerlen, The Netherlands: Open University of the Netherlands.

  16. Film coating van boomzaden met fungiciden tegen kiemplantenziekte

    NARCIS (Netherlands)

    Derkx, M.P.M.; Brouwer, J.

    2008-01-01

    Pasgekiemde zaden of jonge planten van bos- en haagplantsoengewassen en rozenonderstammen vallen regelmatig weg door kiemplantenziekte. Bodemschimmels zoals Botrytis, Fusarium Pythium en Rhizoctonia zijn de boosdoeners. Deze schimmels slaan vooral toe onder natte omstandigheden. Ook in andere landbo

  17. Raamaturappija / Karl Martin Sinijärv

    Index Scriptorium Estoniae

    Sinijärv, Karl Martin, 1971-

    1997-01-01

    Jong, Erica. Hirm viiekümnenda eluaasta ees; Tiigi, Liia. Pühadelaud; Talvet, Jüri. Eesti eleegia ja teisi luuletusi; Tolkien, John Ronald Reuel. Sõrmuse vennaskond. Sõrmuste isand; Masing, Uku. Mälestusi taimedest

  18. Prevalence of suicidal ideation and attempt: associations with ...

    African Journals Online (AJOL)

    ... Muyinda H, Kagee A, Wandiembe P, Mpugu SK, Vancampfort D, Kinyanda E. Prevalence of suicidal ideation and attempt: .... lent in Northern Uganda during active conflict (Roberts ..... de Jong JT, Komproe IH, Van Ommeren M: Com-.

  19. Functional foods: the case for closer evaluation.

    NARCIS (Netherlands)

    Jong, Nynke de; Klungel, Olaf H; Verhagen, Hans; Wolfs, Marion C J; Ocké, Marga C; Leufkens, Hubert G M

    2007-01-01

    Current regulations focus on the mandatory safety evaluation of functional foods before they come to market, but Nynke de Jong and colleagues argue that the effects of such foods should also be evaluated after they have been launched

  20. Traditsioonist ja uuendusest korea modernkunstis / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2005-01-01

    Souli galeriides ja muuseumides valitseb eeldatud kõrgtehnoloogilise kunsti asemel maalikunst. Pikemalt naiskunstnik Wook-kyung Choi (1940-1985) ja Jong-gu Lee näitustest ning soo- ja naisuuringute kongressist "Women's World 2005"

  1. A Reference Model for Mobile Social Software for Learning

    NARCIS (Netherlands)

    De Jong, Tim; Specht, Marcus; Koper, Rob

    2007-01-01

    De Jong, T., Specht, M., & Koper, R. (2008). A reference model for mobile social software for learning. International Journal of Continuing Engineering Education and Life-Long Learning, 18(1), 118-138.

  2. A reference model and technical framework for mobile social software for learning

    NARCIS (Netherlands)

    De Jong, Tim; Specht, Marcus; Koper, Rob

    2008-01-01

    De Jong, T., Specht, M., & Koper, R. (2008). A reference model and technical framework for mobile social software for learning. Presented at the IADIS m-learning 2008 Conference. April, 11-13, 2008, Carvoeiro, Portugal.

  3. Raamaturappija / Karl Martin Sinijärv

    Index Scriptorium Estoniae

    Sinijärv, Karl Martin, 1971-

    1997-01-01

    Jong, Erica. Hirm viiekümnenda eluaasta ees; Tiigi, Liia. Pühadelaud; Talvet, Jüri. Eesti eleegia ja teisi luuletusi; Tolkien, John Ronald Reuel. Sõrmuse vennaskond. Sõrmuste isand; Masing, Uku. Mälestusi taimedest

  4. Contextualised Mobile Media for Learning

    NARCIS (Netherlands)

    De Jong, Tim

    2011-01-01

    De Jong, T. (2011). Contextualised Mobile Media for Learning. June, 10, 2011, Heerlen, The Netherlands: Open University in the Netherlands, CELSTEC. SIKS Dissertation Series No. 2011-09. ISBN 978 90 79447 47 3

  5. The KGB in Eastern Europe during the Cold War: on agents and confidential contacts

    OpenAIRE

    2005-01-01

    Ben de Jong from the University of Amsterdam, Netherlands, discusses the ways in which the KGB collected information about political developments in Eastern Europe during the Cold War and tries to shed some light on the question whether Soviet intelligence services recruited full-fledged agents to acquire the necessary information in the same way as they did in the West. De Jong concentrates on Poland but also tries to grasp the bigger picture and focusses on the distinction between fully-fle...

  6. Anxiety in Patients with Cardiac Disease

    Science.gov (United States)

    2005-01-01

    1997;96:1835- 1842. 43. Tavazzi L, Zotti AM, Mazzuero G. Acute pulmonary edema provoked by psychologic stress: report of two cases. Cardiology. 1987;74...Circulation. 1997;96:1835- 1842. 43. Tavazzi L, Zotti AM, Mazzuero G. Acute pulmonary edema provoked by psychologic stress: report of two cases. Cardiology...De Jong MJ. Cardiogenic shock. Am JNurs. 1997;97(6):40-41. 1997 De Jong M.J, Morton PG. Control of vascular complications after cardiac catheterization

  7. ‘The’ pathway towards the elite level in Dutch basketball: A multidimensional and longitudinal study on the development of talented youth basketball players

    OpenAIRE

    te Wierike, Sanne Cornelia Maria

    2016-01-01

    Veel jonge talentvolle basketballers hebben één doel voor ogen; de top halen in hun sport. Hoe de ontwikkeling van jonge speler tot aan volwassen basketballer verloopt, is onderzocht in het promotieonderzoek van Sanne te Wierike. Dit onderzoek is uitgevoerd bij Bewegingswetenschappen (UMCG, Rijksuniversiteit Groningen). In samenwerking met het Regionaal Trainingscentrum Noord zijn 99 spelers (13 - 19 jaar) van deze jeugdopleiding vijf seizoenen lang gevolgd waarbij verschillende kenmerken zij...

  8. Tugevus ja nõrkus : loovus ja endised tööstusalad Hollandis = Strength and vulnerability : creativity and former indastrial sites in the Netherlands / Klaske Havik

    Index Scriptorium Estoniae

    Havik, Klaske, 1975-

    2005-01-01

    2003. a. septembris Amsterdamis toimunud konverentsist "Loovus ja linn" (peaesineja Richard Florida). Kasvulavade poliitikast. Westergasfabriek'i ümberkujundamisest (AB Mecanoo, Kathryn Gustafson), NDSM-i sadamakai kultuurikeskkonnaks kujundamisest (arhitektuuribürood loetletud) Amsterdamis, disainitehaseks renoveeritud Van Nelle tehasest (renoveerimist juhtis Wessel de Jonge, ruumikujundus: Claessens & Erdmann), ööklubist "Now & Wow" (arhitekt Marten de Jong, disainerid Robbert de Vrieze, Martijn van der Wiel), klubist "Las Palmas" Rotterdamis jm. Bibliograafia lk. 57

  9. Tugevus ja nõrkus : loovus ja endised tööstusalad Hollandis = Strength and vulnerability : creativity and former indastrial sites in the Netherlands / Klaske Havik

    Index Scriptorium Estoniae

    Havik, Klaske, 1975-

    2005-01-01

    2003. a. septembris Amsterdamis toimunud konverentsist "Loovus ja linn" (peaesineja Richard Florida). Kasvulavade poliitikast. Westergasfabriek'i ümberkujundamisest (AB Mecanoo, Kathryn Gustafson), NDSM-i sadamakai kultuurikeskkonnaks kujundamisest (arhitektuuribürood loetletud) Amsterdamis, disainitehaseks renoveeritud Van Nelle tehasest (renoveerimist juhtis Wessel de Jonge, ruumikujundus: Claessens & Erdmann), ööklubist "Now & Wow" (arhitekt Marten de Jong, disainerid Robbert de Vrieze, Martijn van der Wiel), klubist "Las Palmas" Rotterdamis jm. Bibliograafia lk. 57

  10. Twelve-week, prospective, open-label, randomized trial on the effects of an anticholinergic agent or antidiuretic agent as add-on therapy to an alpha-blocker for lower urinary tract symptoms

    Directory of Open Access Journals (Sweden)

    Shin YS

    2014-07-01

    Full Text Available Yu Seob Shin,1 Li Tao Zhang,1 Chen Zhao,2 Young Gon Kim,1 Jong Kwan Park1 1Department of Urology, Chonbuk National University Medical School, and Institute for Medical Sciences, Chonbuk National University and Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University Hospital, Jeonju, South Korea; 2Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, and Shanghai Institute of Andrology, Shanghai, People’s Republic of China Purpose: The effects of an anticholinergic or antidiuretic agent as add-on therapy to an ­alpha-blocker for lower urinary tract symptoms (LUTS according to a voiding diary in 3 days are unknown. We prospectively investigated the efficacy of an anticholinergic or antidiuretic agent as add-on therapy for nocturia in men previously treated with an alpha-blocker for LUTS.Subjects and methods: Patients were randomly subdivided into two groups. All patients had a 4-week washout. Group A had alpha-blocker for 4 weeks, then an alpha-blocker plus an anticholinergic agent for 4 weeks, and, finally, 4 weeks of an alpha-blocker plus an antidiuretic agent. Group B had an alpha-blocker for 4 weeks, then an alpha-blocker plus an antidiuretic agent for 4 weeks, and, finally, 4 weeks of an alpha-blocker plus an anticholinergic agent. In both groups, patients were subdivided into nocturnal polyuria, decreased nocturnal bladder capacity (NBC, or nocturia by both causes subgroups. A 3-day voiding diary, total International Prostate Symptom Score (IPSS, IPSS sub-scores, Overactive Bladder Symptom Score, uroflowmetry, and post-void residual urine volume, were assessed at baseline, and at 4, 8, and 12 weeks.Results: A total of 405 patients completed the study. During treatment, the changes from baseline in total IPSS and IPSS sub-scores were significantly decreased at 4 weeks and were maintained for 12 weeks. In the nocturnal polyuria subgroup of Groups A and B

  11. Effects of anti-vascular endothelial growth factor monoclonal antibody (bevacizumab on lens epithelial cells

    Directory of Open Access Journals (Sweden)

    Jun JH

    2016-06-01

    Full Text Available Jong Hwa Jun,1 Wern-Joo Sohn,2 Youngkyun Lee,2 Jae-Young Kim21Department of Ophthalmology, School of Medicine, Dongsan Medical Center, Keimyung University, 2Department of Oral Biochemistry, School of Dentistry, IHBR, Kyungpook National University, Daegu, South KoreaAbstract: The molecular and cellular effects of anti-vascular endothelial growth factor monoclonal antibody (bevacizumab on lens epithelial cells (LECs were examined using both an immortalized human lens epithelial cell line and a porcine capsular bag model. After treatment with various concentrations of bevacizumab, cell viability and proliferation patterns were evaluated using the water-soluble tetrazolium salt assay and 5-bromo-2'-deoxyuridine enzyme-linked immunosorbent assay, respectively. The scratch assay and Western blot analysis were employed to validate the cell migration pattern and altered expression levels of signaling molecules related to the epithelial–mesenchymal transition (EMT. Application of bevacizumab induced a range of altered cellular events in a concentration-dependent manner. A 0.1–2 mg/mL concentration demonstrated dose-dependent increase in proliferation and viability of LECs. However, 4 mg/mL decreased cell proliferation and viability. Cell migrations displayed dose-dependent retardation from 0.1 mg/mL bevacizumab treatment. Transforming growth factor-β2 expression was markedly increased in a dose-dependent manner, and α-smooth muscle actin, matrix metalloproteinase-9, and vimentin expression levels showed dose-dependent changes in a B3 cell line. Microscopic observation of porcine capsular bag revealed changes in cellular morphology and a decline in cell density compared to the control after 2 mg/mL treatment. The central aspect of posterior capsule showed delayed confluence, and the factors related to EMT revealed similar expression patterns to those identified in the cell line. Based on these results, bevacizumab modulates the proliferation

  12. Self-microemulsifying drug-delivery system for improved oral bioavailability of pranlukast hemihydrate: preparation and evaluation

    Directory of Open Access Journals (Sweden)

    Baek MK

    2013-01-01

    Full Text Available Myoung-Ki Baek,1,* Jong-Hwa Lee,2,* Young-Ho Cho,3 Hak-Hyung Kim,4 Gye-Won Lee3 1Life Science R&D Park, SK Biopharmaceuticals Co, LTD, Daejeon, Republic of Korea; 2Toxicology Center, Korea Institute of Toxicology, Daejeon, Republic of Korea; 3Department of Pharmaceutical Engineering, Konyang University, Nonsan, Republic of Korea; 4R&D Center, Pharvis Korea Pharm, Ansan, Republic of Korea *These authors contributed equally to this workAbstract: The purpose of the present investigation was to develop and evaluate a self-microemulsifying drug delivery system (SMEDDS for improving the oral absorption of a pranlukast hemihydrate (PLH, a very poorly water-soluble drug. An efficient self-microemulsifying vehicle for PLH was selected and optimized using solubility testing and phase diagram construction. The formulations were characterized by assessing self-emulsification performance, droplet size analysis, in vitro drug release characteristics and formulation stability studies. Optimized formulations for in vitro dissolution and bioavailability assessment were Triethylcitrate (TEC; 10%, Tween 20 (50%, Span 20 (25%, triethanolamine (5%, and benzyl alcohol (10%. The SMEDDS readily released the lipid phase to form a fine oil-in-water microemulsion with a narrow distribution size. Saturated solubilities of PLH from SMEDDS in water, pH 4.0 and 6.8, were over 150 times greater than that of plain PLH. The release of 100% PLH from SMEDDS was considerably greater compared to only 1.12% in simulated intestinal fluid (pH 6.8 from plain PLH after 2 hours. The PLH suspension with 0.5% sodium carboxymethylcellulose or 3% PLH-loaded SMEDDS was administrated at a dose of 40 mg/kg as PLH to fasted rats. The absorption of PLH from SMEDDS resulted in about a threefold increase in bioavailability compared with plain PLH aqueous suspension. Our studies illustrated that the potential use of the new SMEDDS can be used as a possible alternative to oral delivery of a poorly

  13. Self-perceived cognitive deficits and their relationship with internalized stigma and quality of life in patients with schizophrenia

    Directory of Open Access Journals (Sweden)

    Shin YJ

    2016-06-01

    Full Text Available Yeon-Jeong Shin,1,2 Yo-Han Joo,1 Jong-Hoon Kim1–3 1Neuroscience Research Institute, 2Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences & Technology, 3Department of Psychiatry, Gil Medical Center, Gachon University School of Medicine, Gachon University, Incheon, Republic of Korea Background: We investigated self-perceived cognitive deficits and their relationship with internalized stigma and quality of life in patients with schizophrenia in order to shed light on the clinical correlates of subjective cognitive deficits in schizophrenia.Methods: Seventy outpatients with schizophrenia were evaluated. Patients’ self-perceived cognitive deficits, internalized stigma, and subjective quality of life were assessed using the Scale to Investigate Cognition in Schizophrenia (SSTICS, the Internalized Stigma of Mental Illness Scale (ISMI, and the Schizophrenia Quality of Life Scale Revision 4 (SQLS-R4, respectively. Correlation and regression analyses controlling for the severity of symptoms of schizophrenia were performed, and a mediation analysis was conducted to examine the hypothesis that internalized stigma mediates the relationship between self-perceived cognitive deficits and subjective quality of life.Results: Pearson’s partial correlation analysis showed significant correlations among the SSTICS, ISMI, and SQLS-R4 scores (P<0.01. Multiple regression analysis showed that the SSTICS and ISMI scores significantly predicted the SQLS-R4 score (P<0.01. Mediation analysis revealed that the strength of the association between the SSTICS and SQLS-R4 scores decreased from β=0.74 (P<0.01 to β=0.56 (P<0.01, when the ISMI score was statistically controlled. The Sobel test revealed that this difference was significant (P<0.01, indicating that internalized stigma partially mediated the relationship between self-perceived cognitive deficits and quality of life.Conclusion: The present study indicates that self

  14. Soluplus®/TPGS-based solid dispersions prepared by hot-melt extrusion equipped with twin-screw systems for enhancing oral bioavailability of valsartan

    Directory of Open Access Journals (Sweden)

    Lee JY

    2015-05-01

    Full Text Available Jae-Young Lee,1,* Wie-Soo Kang,2,* Jingpei Piao,2 In-Soo Yoon,3 Dae-Duk Kim,1 Hyun-Jong Cho4 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 2School of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 3College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam, 4College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea *These authors contributed equally to this work Background: Soluplus® (SP and ᴅ-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS–based solid dispersion (SD formulations were developed by hot-melt extrusion (HME to improve oral bioavailability of valsartan (VST. Methods: HME process with twin-screw configuration for generating a high shear stress was used to prepare VST SD formulations. The thermodynamic state of the drug and its dispersion in the polymers were evaluated by solid-state studies, including Fourier-transform infrared, X-ray diffraction, and differential scanning calorimetry. Drug release from the SD formulations was assessed at pH values of 1.2, 4.0, and 6.8. Pharmacokinetic study was performed in rats to estimate the oral absorption of VST. Results: HME with a high shear rate produced by the twin-screw system was successfully applied to prepare VST-loaded SD formulations. Drug amorphization and its molecular dispersion in the polymer matrix were verified by several solid-state studies. Drug release from SD formulations was improved, compared to the pure drug, particularly at pH 6.8. Oral absorption of drug in rats was also enhanced in SP and TPGS-based SD groups compared to that in the pure drug group. Conclusion: SP and TPGS-based SDs, prepared by the HME process, could be used to improve aqueous solubility, dissolution, and oral absorption of poorly water-soluble drugs. Keywords: hot-melt extrusion, oral bioavailability, solid dispersion, valsartan  

  15. Effectiveness of elastic band-type ankle–foot orthoses on postural control in poststroke elderly patients as determined using combined measurement of the stability index and body weight-bearing ratio

    Directory of Open Access Journals (Sweden)

    Kim JH

    2015-11-01

    Full Text Available Jong Hyun Kim, Woo Sang Sim, Byeong Hee Won Usability Evaluation Technology Center, Advanced Biomedical and Welfare R&D Group, Korea Institute of Industrial Technology, Cheonan-si, Chungcheongnam-do, South Korea Purpose: Poor recovery of postural stability poststroke is the primary cause of impairment in activities and social participation in elderly stroke survivors. The purpose of our study was to experimentally evaluate the effectiveness of our new elastic ankle–foot orthosis (AFO, compared to a traditional AFO fabricated with hard plastic, in improving postural stability in elderly chronic stroke survivors. Patients and methods: Postural stability was evaluated in ten chronic stroke patients, 55.7±8.43 years old. Postural stability was evaluated using the standardized methods of the Biodex Balance System combined with a foot pressure system, under three experimental conditions, no AFO, rigid plastic AFO, and elastic AFO (E-AFO. The following dependent variables of postural stability were analyzed: plantar pressure under the paretic and nonparetic foot, area of the center of balance (COB and % time spent in each location, distance traveled by the COB away from the body center, distance traveled by the center of pressure, and calculated index of overall stability, as well as indices anterior–posterior and medial–lateral stability. Results: Both AFO designs improved all indices of postural stability. Compared to the rigid plastic AFO, the E-AFO produced additional positive effects in controlling anterior–posterior body sway, equalizing weight bearing through the paretic and nonparetic limbs, and restraining the displacement of the center of pressure and of the COB. Conclusion: Based on our outcomes, we recommend the prescription of E-AFOs as part of a physiotherapy rehabilitation program to promote recovery of postural stability poststroke. When possible, therapeutic outcomes should be documented using the Biodex Balance System and

  16. Recent progress on technologies and applications of transgenic ...

    African Journals Online (AJOL)

    USER

    2010-06-14

    Jun 14, 2010 ... applications (Scott and Lois, 2005; van de Lavoir et al.,. 2006b ..... Kwon MS, Koo BC, Choi BR, Lee HT, Kim YH, Ryu WS, Shim H, Kim JH,. Kim NH, Kim .... Severino C, David FD, Shrikant D, Jennifer HD, Lynae G, Edward LH,.

  17. EDITORIAL: Focus on Plasma Medicine

    Science.gov (United States)

    Morfill, G. E.; Kong, M. G.; Zimmermann, J. L.

    2009-11-01

    -pressure microwave plasmas in an N2 and O2 gas mixture M K Singh, A Ogino and M Nagatsu Degradation of adhesion molecules of G361 melanoma cells by a non-thermal atmospheric pressure microplasma H J Lee, C H Shon, Y S Kim, S Kim, G C Kim and M G Kong The acidification of lipid film surfaces by non-thermal DBD at atmospheric pressure in air A Helmke, D Hoffmeister, N Mertens, S Emmert, J Schuette and W Vioel Reduction and degradation of amyloid aggregates by a pulsed radio-frequency cold atmospheric plasma jet D L Bayliss, J L Walsh, G Shama, F Iza and M G Kong The effect of low-temperature plasma on bacteria as observed by repeated AFM imaging René Pompl, Ferdinand Jamitzky, Tetsuji Shimizu, Bernd Steffes, Wolfram Bunk, Hans-Ulrich Schmidt, Matthias Georgi, Katrin Ramrath, Wilhelm Stolz, Robert W Stark, Takuya Urayama, Shuitsu Fujii and Gregor Eugen Morfill Removal and sterilization of biofilms and planktonic bacteria by microwave-induced argon plasma at atmospheric pressure Mi Hee Lee, Bong Joo Park, Soo Chang Jin, Dohyun Kim, Inho Han, Jungsung Kim, Soon O Hyun, Kie-Hyung Chung and Jong-Chul Park Cell permeabilization using a non-thermal plasma M Leduc, D Guay, R L Leask and S Coulombe Physical and biological mechanisms of direct plasma interaction with living tissue Danil Dobrynin, Gregory Fridman, Gary Friedman and Alexander Fridman Nosocomial infections-a new approach towards preventive medicine using plasmas G E Morfill, T Shimizu, B Steffes and H-U Schmidt Generation and transport mechanisms of chemical species by a post-discharge flow for inactivation of bacteria Takehiko Sato, Shiroh Ochiai and Takuya Urayama Low pressure plasma discharges for the sterilization and decontamination of surfaces F Rossi, O Kylián, H Rauscher, M Hasiwa and D Gilliland Contribution of a portable air plasma torch to rapid blood coagulation as a method of preventing bleeding S P Kuo, O Tarasenko, J Chang, S Popovic, C Y Chen, H W Fan, A Scott, M Lahiani, P Alusta, J D Drake and M Nikolic A two

  18. Efficacy of fimasartan/hydrochlorothiazide combination in hypertensive patients inadequately controlled by fimasartan monotherapy

    Directory of Open Access Journals (Sweden)

    Rhee MY

    2015-06-01

    Full Text Available Moo-Yong Rhee,1 Sang Hong Baek,2 Weon Kim,3 Chang Gyu Park,4 Seung Woo Park,5 Byung-Hee Oh,6 Sang-Hyun Kim,7 Jae-Joong Kim,8 Joon-Han Shin,9 Byung-Su Yoo,10 Se-Joong Rim,11 Jong-Won Ha,12 Joon Hyung Doh,13 Youngkeun Ahn,14 Jei Keon Chae,15 Jeong Bae Park,16 Soon-Kil Kim,17 Cheol Ho Kim18 1Cardiovascular Center, Dongguk University Ilsan Hospital, Goyang, 2Catholic University of Korea, Seoul St Mary’s Hospital, Seoul, 3Cardiovascular Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, 4Division of Cardiology, Guro Hospital, Korea University College of Medicine, Seoul, 5Division of Cardiology, Samsung Medical Center, Seoul, 6Department of Internal Medicine, Seoul National University Hospital, Seoul, 7Division of Cardiology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, 8Division of Cardiology, Asan Medical Center, Seoul, 9Division of Cardiology, Ajou University Hospital, Suwon, 10Division of Cardiology, Wonju Severance Christian Hospital, Wonju, 11Division of Cardiology, GangNam Severance Hospital, Seoul, 12Division of Cardiology, Severance Hospital, Seoul, 13Division of Cardiology, Inje University Ilsan Hospital, Goyang, 14Department of Cardiology, Chonnam National University Hospital, Gwangju, 15Chonbuk National University Hospital, Jeonju, 16Department of Cardiology, Cheil General Hospital, Dankook University College of Medicine, Seoul, 17Department of Cardiology, Hanyang University Guri Hospital, Guri, 18Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Background: The study reported here compared the blood pressure (BP-lowering efficacy of fimasartan alone with that of fimasartan/hydrochlorothiazide (HCTZ combination in patients whose BP goal was not achieved after 4 weeks of treatment with once-daily fimasartan 60 mg.Methods: Patients with sitting diastolic blood pressure (siDBP ≥90 mmHg with 4 weeks of once

  19. Enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems: physicochemical characterization and in vivo investigation

    Directory of Open Access Journals (Sweden)

    Yousaf AM

    2015-03-01

    Full Text Available Abid Mehmood Yousaf,1 Dong Wuk Kim,1 Yu-Kyoung Oh,2 Chul Soon Yong,3 Jong Oh Kim,3 Han-Gon Choi11College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 2College of Pharmacy, Seoul National University, Seoul, 3College of Pharmacy, Yeungnam University, Gyongsan, South KoreaBackground: The intention of this research was to prepare and compare various solubility-enhancing nanoparticulated systems in order to select a nanoparticulated formulation with the most improved oral bioavailability of poorly water-soluble fenofibrate.Methods: The most appropriate excipients for different nanoparticulated preparations were selected by determining the drug solubility in 1% (w/v aqueous solutions of each carrier. The polyvinylpyrrolidone (PVP nanospheres, hydroxypropyl-β-cyclodextrin (HP-β-CD nanocorpuscles, and gelatin nanocapsules were formulated as fenofibrate/PVP/sodium lauryl sulfate (SLS, fenofibrate/HP-β-CD, and fenofibrate/gelatin at the optimized weight ratios of 2.5:4.5:1, 1:4, and 1:8, respectively. The three solid-state products were achieved using the solvent-evaporation method through the spray-drying technique. The physicochemical characterization of these nanoparticles was accomplished by powder X-ray diffraction, differential scanning calorimetry, scanning electron microscopy, and Fourier-transform infrared spectroscopy. Their physicochemical properties, aqueous solubility, dissolution rate, and pharmacokinetics in rats were investigated in comparison with the drug powder.Results: Among the tested carriers, PVP, HP-β-CD, gelatin, and SLS showed better solubility and were selected as the most appropriate constituents for various nanoparticulated systems. All of the formulations significantly improved the aqueous solubility, dissolution rate, and oral bioavailability of fenofibrate compared to the drug powder. The drug was present in the amorphous form in HP-β-CD nanocorpuscles; however, in

  20. Polymer coated gold nanoparticles for tracing the mobility of engineered nanoparticles in the subsurface

    Science.gov (United States)

    Uthuppu, Basil; Sidelmann Fjordbøge, Annika; Caspersen, Eva; Broholm, Mette Martina; Havsteen Jakobsen, Mogens

    2014-05-01

    also show significant partitioning to organic phases such as tetrachloroethylene (PCE) and trichloroethylene (TCE), which are considered as potential ground water pollutants accumulated in the subsurface as DNAPLs (dense non-aqueous phase liquids). Being a noble metal, nanogold is to be detected by nondestructive optical methods at a concentration of at least 1000 fold lower than ENPs. Using conventional spectrophotometric technique equipped with liquid waveguide capillary cell (LWCC), nanogold is detected at very low concentration range (1 ppm - 62.5 ppb). Compared to uncoated particles, surface modified nanogold with polymers retains the plasmonic peaks at 520 nm when diluted with artificial ground water. Acknowledgement: The low level detection of nanogold using LWCC was done at the department of nuclear and quantum engineering, KAIST (Korea Advance Institute of Science and Technology), 291 Daehak-ro, (373-1, Guseong-dong), Yuseong-gu, Daejeon 305-701, Republic of KOREA. We acknowledge Prof. Woojin Lee, Prof. Jong-Il Yun, Kim A Young and Tae Hyeong Kim for the same.

  1. Fall proof: improving mobility and balance Elizabeth Best-Martini Fall proof: improving mobility and balance and Kim A Botenhagen-Di Genova Human Kinetics £24.50 0 73603 687 3 0736036873 Debra Rose Human Kinetics £38 0 73604 088 9 0736040889.

    Science.gov (United States)

    2003-09-01

    A structured balance and mobility-training programme specifically designed to reduce physical frailty and the rising incidence of falls among older people. This practical manual blends theory into practical applications and covers an introduction to the body systems, balance assessments and a discussion of contemporary motor learning principles. Tel: Customer Services 0113 255 5665. Email: hk@hkeurope.com.

  2. On the Legal Liability of Tort of Foreign Infectious Disease Spreaders---Taking the Case of Korean MERS Sufferer Kim for Example%外国人传播传染病所发生之侵权行为的法律责任--以韩国MERS患者金某案为例

    Institute of Scientific and Technical Information of China (English)

    金成华

    2016-01-01

    From May to June,2015, Middle East Respiratory Syndrome (MERS) broke out in South Korea. One MERS sufferer, a Korean man named Jin who came to China on business carrying this virus, became the first MERS patient in China. Because of him, China paid a high price. This event set off a public discussion on "how to pursue legal liability of foreign infectious disease spreaders" in China. On the question of how to bear legal responsibility, the law lay particular stress on the administrative and criminal liability in our country, but it still exists large legal blanks in the field of civil liability such as tort liability, etc.. So it is necessary to discuss the legal liability of tort of foreign infectious disease spreaders with emphasis from the perspective of tort liability law.%2015年5月至6月,韩国出现中东呼吸综合症(MERS)疫情,一位患上MERS的韩国人金某因带病毒出差到我国,成为我国发现的首例MERS患者,并使我国付出了昂贵的代价。此后,国内掀起“如何追究外国人传播传染病的法律责任”的大讨论,在事主如何承担法律责任问题上,我国法律偏重规定了行政和刑事责任,但在侵权责任等民事责任领域仍存在较大的法律空白。鉴此,有必要以侵权责任法为视角,探讨外国人因传播传染病而发生的侵权行为之法律责任的相关问题,在此基础上提出完善立法等法律解决途径。

  3. 浅析美国大众媒体对司法办案的影响--以“罗德尼•金案”为例%A Brief Analysis of the Influence of Mass Media on Court Judgment:With Special Reference to the Case of Rodney Kim

    Institute of Scientific and Technical Information of China (English)

    董明利

    2015-01-01

    Rodney King vs Los Angeles Police Station is one of the most controversial cases in American history. It should have been an irrefutable case if the public had not been misled by clipped videotape and distorted reports of the mass media. As a result, it triggered a devastating havoc and caused a series of negative influence and consequences. This not only fully reflected the impacts that mass media and public opinions may have on court judgment, but also displayed the complicated racial relations in American society, the multi-facets of its democratic system and increasingly serious class clashes.%“罗德尼·金案”是美国历史上最受争议的案件之一。原本证据确凿的案件却因大众媒体的介入,通过删减过的录像和偏离事实真相的报道误导民众,从而引发了一场前所未有的都市大暴乱,产生巨大的轰动效应和无法挽回的后果。这既充分显示出媒体和大众舆论对于司法审判的影响,又从侧面反映出美国社会中复杂的种族关系,多面的民主制度和日益突出的阶级问题。

  4. Informatics Observed [and] Agenda: A Tool for Agenda Setting Research [and] Telos Language Partner: Multimedia Language Learning, Authoring and Customisation [and] Towards a Consumer Perspective on Information Behaviour Research [and] The Digital Library as Access Management Facilitator [and] Knowledge and Information Management (KIM'21) [and] Perspectives of ICT in Professional Development and Education.

    Science.gov (United States)

    Cawkell, Tony; Kok, Yeong Haur; Goh, Angela; Holaday, Duncan; Hoffstaedter, Petra; Kohn, Kurt; Rowley, Jennifer; van Halm, Johan; Pye, Jo

    1999-01-01

    The following collection of articles reprinted from "CD ROM and Online Review" include "a new way of learning." Discuses research and development funding in educational technology and recommends to offer vast sums to investigate the best way of teaching a particular topic, and through that to fund the use of computers as an incidental part of the…

  5. 区域艺术发展势头强劲-ACAF NY 2008执行总监Cristal Kim访谈%Strong momentum of regional art development-Special interview of Cristal Kim,executive supervisor of ACAF NY 2008

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ ACAF是一个中型的艺术博览会,注重与本地对亚洲当代文化和艺术有兴趣的画廊、机构和企业的合作,同时致力于在纽约提升亚洲的当代文化和艺术.在ACAF2008即将举办之际,对ACAF NY 2008执行总监Cristal Kim进行了专访.

  6. Tracking Theory Building and Use Trends in Selected LIS Journals: More Research is Needed. A review of: Kim, Sung‐Jin, and Dong Y. Jeong. “An Analysis of the Development and Use of Theory in Library and Information Science Research Articles.” Library & Information Science Research 28.4 (Sept. 2006: 548‐62.

    Directory of Open Access Journals (Sweden)

    Carol Perryman

    2007-09-01

    Full Text Available Objective ‐ The authors measure theory incidents occurring in four LIS journals between 1984‐2003 in order to examine their number and quality and to analyze them by topic. A third objective, only identified later in the text of the study, was to compare theory development and use between Korean and international journals. Research questions asked include whether LIS has its own theoretical base as a discipline, and what characteristics the theoretical framework has.Design – Bibliometric study.Setting – Journal issues selected from four LIS journals for the time span from 1984 ‐ 2003.Subjects – Two international journals, Journal of the American Society for Information Science and Technology (JASIST and Library and Information Science Research (LISR were selected based on their high ranking in the Social Sciences Citation Index (SSCI impact factors. Two Korean journals, Journal of the Korean Society for Information Management (JKSIM and Journal of the Korean Society for Library and Information Science (JKSLIS were selected.Methods ‐ After having determined a definition of theory, and identifying different levels of theory, the authors set up rules for the identification of theory incidents, which are defined as “events in which the author contributed to the development or the use of theory in his/her own paper” (550. Content analysis of 1661 research articles was performed to measure theory incidents according to working definitions. Interrater reliability was ensured by conducting independent coding for “subfield classification, identification of theory incidents, and quality measurement” (555,using a sample of 199 articles (random selection not specified, achieving 94‐97% interrater reliability. Incidents, once identified, were evaluated for quality using Dubin’s “efficiency of law” criteria, involving measures of relatedness, directionality, co‐variation, rate of change, and “profundity,” defined as the depth to which theory is incorporated into the research study.Main Results ‐ 21.79% (n=362 of the articles contained theory incidents that were analyzed and evaluated. Trend measurement indicated an overall increase, although a slight decrease was shown in the year range 1993‐2003. International journals accounted for 61.33% of theory incidents, compared to 38.67% for the Korean journals. T‐testing showed that differences in means between Korean and international journals were not statistically significant. Topical theory areas were ranked by frequency. The top five areas were shown to be nearly identical between Korean and international journals. ANOVA was performed with significant results in the difference between efficiency ratings. Conclusion – The authors find that the overall proportion of theory incidents including both theory development and use increased through the 20‐year time span examined, and that LIS has established its own theoretical framework based upon the frequency of incidents.

  7. 数据丢失防护:无法回避的信息安全问题——访赛门铁克公司DLP解决方案全球高级主管Ken Kim%Defence of data loss: an inevitable problem in Information security

    Institute of Scientific and Technical Information of China (English)

    李勇

    2009-01-01

    2005年,美国花旗集团丢失了一张载有390万客户银行账号、历史支付数据以及社会保障卡号的计算机磁盘;2008年3月,英国汇丰银行丢失了一张重要的数据光盘,光盘内存有37万名寿险投保客户资料,包括客户姓名、生日和投保等级;此外,纽约银行梅隆公司最近宣布其所丢失的一盒备份磁带上保存着全国范围内未经加密的1200万客户的信息,

  8. Allostreptomyces psammosilenae gen. nov., sp. nov., an endophytic actinobacterium isolated from the roots of Psammosilene tunicoides and emended description of the family Streptomycetaceae [Waksman and Henrici (1943)AL] emend. Rainey et al. 1997, emend. Kim et al. 2003, emend. Zhi et al. 2009.

    Science.gov (United States)

    Huang, Mei-Juan; Rao, Manik Prabhu Narsing; Salam, Nimaichand; Xiao, Min; Huang, Hai-Quan; Li, Wen-Jun

    2017-02-01

    A Gram-stain-positive actinobacterium, designated strain YIM DR4008T, was isolated from the root sample of Psammosilene tunicoides collected from Lijiang, Yunnan, China. Strain YIM DR4008T could grow at temperatures ranging from 10 to 50 °C (optimum 28-30 °C), at pH 5.0-11.0 (optimum pH 7.0) and in the presence of up to 4 % (w/v) NaCl. Sequence analysis of the 16S ribosomal RNA gene revealed that strain YIM DR4008T shared highest similarity (95.0 %) with Streptomyces griseoplanus NBRC 12779T and 10 %) were anteiso-C15 : 0, C16 : 0, iso-C16 : 0, iso-C15 : 0 and anteiso-C17 : 0. The genomic DNA G+C content was determined to be 75.3 mol%. Based on the phenotypic, chemotaxonomic and molecular characteristics, strain YIM DR4008T is proposed to be recognized as a novel species of a new genus in the family Streptomycetaceae, with the name Allostreptomyces psammosilenae gen. nov., sp. nov. The type strain of the type species is YIM DR4008T (=DSM 42178T=CGMCC 4.7247T). An emended description of the family Streptomycetaceae is also provided.

  9. Informatics Observed [and] Agenda: A Tool for Agenda Setting Research [and] Telos Language Partner: Multimedia Language Learning, Authoring and Customisation [and] Towards a Consumer Perspective on Information Behaviour Research [and] The Digital Library as Access Management Facilitator [and] Knowledge and Information Management (KIM'21) [and] Perspectives of ICT in Professional Development and Education.

    Science.gov (United States)

    Cawkell, Tony; Kok, Yeong Haur; Goh, Angela; Holaday, Duncan; Hoffstaedter, Petra; Kohn, Kurt; Rowley, Jennifer; van Halm, Johan; Pye, Jo

    1999-01-01

    The following collection of articles reprinted from "CD ROM and Online Review" include "a new way of learning." Discuses research and development funding in educational technology and recommends to offer vast sums to investigate the best way of teaching a particular topic, and through that to fund the use of computers as an incidental part of the…

  10. Reklamların ve Cinsiyet Kimliği Rolünün Tüketicilerin Satın Alma Davranışları Üzerindeki Etkisi = The Effect of Advertisements and Gender Identity Role on Consumer Buying Behavior

    Directory of Open Access Journals (Sweden)

    Mehmet İsmail YAĞCI

    2010-01-01

    Full Text Available Gender is a segmentation criterion which has been used for a long time especially for the analyses of consumer behavior in traditional marketing. However an obligation has aroused to digress the traditional patterns in order to understand consumer behavior in our rapidly changing world. At this point, “gender identity role” concept which is frequently encountered in the literature reminded may help researchers in understanding complex consumer buying behavior. In this study, consumer’s gender identity’s impact on their response to advertisements and whether their socio-economic status levels’ effect their gender identities or not have been analyzed and some significant relations have been found.

  11. 不同土壤环境对地枫皮幼苗生长和生物量分配的影响%Effect of Different Soil Conditions on the Growth and Biomass Allocation of Illicium difengpi K.I.B.et K.I.M Seedlings

    Institute of Scientific and Technical Information of China (English)

    王满莲; 孔德鑫; 邹蓉; 柴胜丰; 陈宗游; 唐辉

    2013-01-01

    The seedlings of Illicium difengpi were planted in four soil conditions (soil nutrient availability sequence was lime soil,mixed soil,garden soil and fire soil).Then the effect of the soil conditions on the growth and biomass allocation of seedlings were investigated.The results showed that the growth and survival ratio of seedlings were affected significantly by soil nutrient.With the increase of nutrient content,the seedling height,basal diameter,crown width,and the fresh and dry weight of different plant parts increased significantly.Moreover,seedling developed stronger roots.Illicium difengpi could grow and develop in lime soil,mixed soil,garden soil and fire soil,and respond to heterogeneity soil nutrient availability by adjusting biomass partitioning to various organs.Under the low soil nutrient level,lllicium difengpi allocated more biomass to root,and its root mass ratio and root mass/crown mass were significantly increased.Under the high soil nutrient level,it allocated more biomass to leaf,and its leaf mass ratio was significantly increased.Illicium difengpi seedlings grew best in lime soil with higher survival ratio,and the highest survival ratio was obtained in fire soil.We conjectured that Illicium difengpi seedlings grow better in nutrient-rich fire soil with high ash content.As a result of high cost of lime soil,we recommend that people cultivate Illicium difengpi seedlings in nutrient-rich fire soil.%比较研究了4种土壤环境(养分含量高低依次为:石灰土>混合土>园土>火烧土)对地枫皮种子苗生长和生物量分配的影响.结果表明:不同土壤环境显著影响地枫皮幼苗的生长与成活率,随着土壤养分含量的增高,地枫皮幼苗的株高、基径和冠宽均显著增大,植株不同部位的干鲜重也均显著增大,地下根系更加粗壮发达.地枫皮幼苗可以通过调节生物量分配来适应养分环境的变化,养分水平低时,分配更多的生物量到根,根生物量比和根/冠比增大,养分水平高时,分配更多的生物量到叶,叶生物量比增加.石灰土栽培地枫皮幼苗能获得最好的生长和较高的成活率,火烧土栽培地枫皮幼苗的成活率最高,由于使用石灰土成本较高,建议采用灰分高的火烧土培育地枫皮幼苗.

  12. Power relations within the Situationist International

    DEFF Research Database (Denmark)

    Baumeister, Ruth

    2016-01-01

    This proposal presents the Dutch artist Jacqueline de Jong, (*1939, NL), and the French author/artist Michelle Bernstein, (*1932, F), two major of the very few women within the Situationist International movement. What both have in common is that as young women, they were related to the founding...... members and major actors of the group. Therefore, within the discourse of the Situationist International, de Jong is usually described as the muse of the 25 year older, at that point internationally acclaimed Danish artist. Bernstein, to the contrary, is pictured as the one who provided a living not only...... exhibition practise on the Situationist International contributes to this rather one -­‐sided reading of “de Jong, the muse” and “Bernstein the breadwinner” in order to reveal, to which extent this either conforms or opposes to the results of the analysis in the first part....

  13. Power relations within the Situationist International

    DEFF Research Database (Denmark)

    Baumeister, Ruth

    2016-01-01

    This proposal presents the Dutch artist Jacqueline de Jong, (*1939, NL), and the French author/artist Michelle Bernstein, (*1932, F), two major of the very few women within the Situationist International movement. What both have in common is that as young women, they were related to the founding...... members and major actors of the group. Therefore, within the discourse of the Situationist International, de Jong is usually described as the muse of the 25 year older, at that point internationally acclaimed Danish artist. Bernstein, to the contrary, is pictured as the one who provided a living not only...... exhibition practise on the Situationist International contributes to this rather one -­‐sided reading of “de Jong, the muse” and “Bernstein the breadwinner” in order to reveal, to which extent this either conforms or opposes to the results of the analysis in the first part....

  14. [Trends in research on the history of medicine in Korea before the modern era].

    Science.gov (United States)

    Shin, Dongwon

    2010-06-30

    Research on the history of medicine in Korea in the form of modern scholarship began with the publication in 1930 of Yi Neunghwa's "A History of the Development of Medicine in Korea." The purpose of the present study lies in surveying studies on the history of medicine in Korea in the past 80 years since the publication of Yi's paper. In terms of periodization, research on the history of medicine in Korea is bifurcated by the publication of two comprehensive histories-i. e., Miki Sakae's A History of Medicine and Disease in Korea (1963) and Kim Du-jong's The Complete History of Medicine in Korea (1966). Indeed, all earlier studies converged in these two books. Because Miki and Kim both had majored in Western medicine and conducted research based on similar perspectives, data, and methods, the two works overlap considerably, and Kim's book, as the later of the two, unfortunately lost the initiative to the former to a considerable extent. As a result of these two scholars' research, it became possible to trace the overall flow of the history of medicine in Korea. Following the publication of works by Miki and Kim and with the advent of the 1980's, research on the history of medicine in premodern Korea was renovated with the emergence of no fewer than some dozen new doctoral degree holders in the field. In fact, these young scholars went beyond surveying trends in each era to expand the scope of specific discussions and topics per era, to delve into the actual contents, and to elucidate the function of medicine in society. The fruits of studies conducted in the past 80 years on the history of medicine in premodern Korea can be summarized as follows. 1) before the 5th century AD: the existence of a comprehensive medical practice in regions inhabited by those considered to be the ancestors of the Korean people; and information on medication including ginseng. 2) 5th-10th centuries: the existence of professional medical posts; the management of medicine by the royal

  15. #Politics on Twitter goes beyond the left-right ideology divide

    OpenAIRE

    Bode, Leticia; Hanna, Alex; Yang, JungHwan; Shah, Dhavan V.

    2015-01-01

    In U.S. politics, the main narrative tends to manifest as left vs right, Democrat vs. Republican, but is this reflected in the social media sphere as well? In new research which maps how hashtags in political tweets were used in the lead up to the 2010 Congressional midterm elections, Leticia Bode, Alex Hanna, JungHwan Yang, and Dhavan V. Shah found that some hashtags occurred in discussion groups that were there ideological opposite. They write that this ‘hashjacking’ was a way in which cons...

  16. Prediction by data mining, of suicide attempts in Korean adolescents: a national study

    OpenAIRE

    Bae SM; Lee SA; Lee SH

    2015-01-01

    Sung Man Bae,1 Seung A Lee,2 Seung-Hwan Lee2,3 1Department of Counseling Psychology, The Cyber University of Korea, Seoul, South Korea; 2Clinical Emotion and Cognition Research Laboratory, Goyang, South Korea; 3Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, South Korea Objective: This study aimed to develop a prediction model for suicide attempts in Korean adolescents.Methods: We conducted a decision tree analysis of 2,754 middle and hig...

  17. Wrappers for Performance Enhancement and Oblivious Decision Graphs

    Science.gov (United States)

    1995-09-01

    Sklansky 1988), best- rst search (Xu, Yan & Chang 1989), and genetic algorithms (Vafai & De Jong 1992, Vafai & De Jong 1993). All the algorithms...worthwhile to introduce some diversity into the search, following the genetic algorithm and genetic programming approaches (Holland 1992, Goldberg 1989, Koza...h eav ily u sed b y C 4.5. A clo ser in sp ection sh ow s th at th e d iscretization algorith m d iscretized th is featu re in to on e in terval, th

  18. The state of research after 25 years of Nanotechnology

    Science.gov (United States)

    Demming, Anna

    2013-01-01

    In 1990 the transistor was big—not just hugely prevalent in day-to-day devices but literally large in size compared with present day counterparts. Still, as Christoph Gerber describes in our latest Nanotechnology Discussions podcast [1], with transistor footprints decreasing every two years as described in Moore's law, by 1990 the electronics industry saw itself broaching new territory: nanotechnology. Atoms had made their debut as real-world observables with the first scanning probe microscopes only a few years previously, prompted by efforts to understand how physical systems behave at this scale. And in this heady climate of burgeoning nanoscale innovations Nanotechnology published its first issue, the world's first academic journal dedicated to nanoscale science and technology. This year the journal publishes its 25th volume and to celebrate we have commissioned a special issue presenting a snapshot of developments leading some of the most active areas in the field today [2]. As nanotechnology has matured both device-focused and fundamental research have placed high demands on improving fabrication processes to generate structures cheaply, efficiently and reliably. Since its discovery graphene has been under close scrutiny for the potential to exploit its optical transparency, mechanical flexibility and high carrier mobility. 'However', point out Ho Cho, Jong-Hyun Ahn and colleagues in Korea, 'it is still significantly challenging to develop clean and simple fabrication procedures'. They demonstrate how photo-curable ion gel gate dielectrics can be used to produce self-aligned flexible graphene transistors and inverters [3] simply without extra graphene-patterning steps. Sang Ouk Kim and colleagues at the Korea Advanced Institute of Science and Technology demonstrate another method for avoiding complex fabrication techniques, creating highly aligned graphene nanoribbon with their mussel-inspired block copolymer lithography and directed self-assembly [4

  19. 76 FR 1431 - Public Water System Supervision Program Revision for the State of New Mexico

    Science.gov (United States)

    2011-01-10

    ... Avenue, Suite 1200, Dallas, Texas 75202. FOR FURTHER INFORMATION CONTACT: Bill Hurlbut or Dzung Kim Ngo...-8305/7158 (Hurlbut/Ngo Kidd), or by e-mail ( hurlbut.bill@epa.gov , ngo.kim@epa.gov )....

  20. The Philippine Response to Terrorism: The Abu Sayyaf Group

    Science.gov (United States)

    2004-12-01

    with a highly intolerant religious credo that calls for the deliberate and 106 Sidney Tarrow cited in Kim...Kumar, The New Terrorism: Anatomy, Trends and Counter-Strategies (Singapore: Eastern Universities Press, 2002). Tarrow , Sidney , cited in Kim Cragin

  1. Transitions and Time: Dissonance between Social and Political Aging in South Korea

    Directory of Open Access Journals (Sweden)

    Won Jee Cho

    2012-05-01

    Full Text Available This study explored multidimensional meanings related to “becoming old” for the young-old in South Korean society. Six persons aged 62 to 68 were interviewed in-depth. They chronologically, physically, and socially experienced the transition to old age at different times determined through “Hwan-Gap” (at age 60 and through current social policies that define entry into elderhood (at age 65. However, most did not psychologically accept their own aging as beginning at age 60 with “Hwan-Gap.” They reported that they were “forced” to become old at that time, even though they did not yet qualify for old age benefits provided by the South Korean government. In addition, they did not consider others’ perceptions of them as “old” as a psychological obstacle to defining themselves as young. Knowledge about young-old persons’ dissonance between their identities and sociopolitical views of entry into elderhood is important for understanding their experiences during the five-year gap between sociocultural entry into old age at age 60 and entry into the nationally defined elderhood at age 65.

  2. Time-and Space-Resolved Spectroscopic Investigation on pi-Conjugated Nanostructures

    Science.gov (United States)

    2014-07-30

    Bonding Interactions of meso-Imidazolyl Groups Hirotaka Mori, Young Mo Sung, Byung Sun Lee, Dongho Kim and Atsuhiro Osuka Angew . Chem. Int. Ed...Chi, Jun Ding, Juan Casado, Dongho Kim and Jishan Wu Angew . Chem. Int. Ed., 52(33), 8561-8565. August 12, 2013 13. S2 Fluorescence Dynamics of...meso-Aryl-substituted Subporphyrins Jooyoung Sung, Pyosang Kim, Shun Saga, Shin-ya Hayashi, Atsuhiro Osuka, and Dongho Kim Angew . Chem. Int. Ed., 52

  3. 77 FR 44310 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Science.gov (United States)

    2012-07-27

    ... KEEHOWAN KIM MI LIE KIM MYUNG OK KIM YEONG JUN KONDRATIEV MARIE NADEJDA KOO DOROTHEA GERALDINE KRAMER... LEE ANDREW HENRY LEE BONG LEE DENNIS JEE-WOO DEAN LEE TONY KWOK CHEN LEE VICTORIA KATIE LEE WENDY WAI... WOO TRACY YANG BESSIE SHIH-FUN YEN RICHARD TSAN KWONG YEUNG ANDREW YEUNG CARMEN YI HYON SUN YI...

  4. Tubular kidney injury molecule-1 in protein-overload nephropathy

    NARCIS (Netherlands)

    van Timmeren, Mirjan M.; Bakker, Stephan J. L.; Vaidya, Vishal S.; Bailly, Veronique; Schuurs, Theo A.; Damman, Jeffrey; Stegeman, Coen A.; Bonventre, Joseph V.; van Goor, Harry

    2006-01-01

    Kim-1, a recently discovered membrane protein, is undetectable in normal kidneys but markedly induced in proximal tubules after ischemic and toxic injury. The function of Kim-1 is unclear, but it is implicated in damage/repair processes. The Kim-1 ectodomain is cleaved by metalloproteinases and dete

  5. West European and East Asian Perspectives on Defense, Deterrence and Strategy. Volume 6. South Korean Perspectives on Defense, Deterrence and Strategy.

    Science.gov (United States)

    1984-04-11

    1975/76. 71. Kim C. I. Eugene , "Emergency, Development, and Human Rights: South Korea," Asian Survey, April 1978, pp. 363-378. 72. Kim Il, "Concerning...to Bellicose Stance," The Korea Herald, July 24, 1981. - 131. Dal Chooing Kim, "S-N Dialogue Depends on Pyongyang," The Korea Herald, July 24, 1981

  6. Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation

    NARCIS (Netherlands)

    Nijboer, W. N.; Schuurs, T. A.; Damman, J.; van Goor, H.; Vaidya, V. S.; van der Heide, J. J. Homan; Leuvenink, H. G. D.; Bonventre, J. V.; Ploeg, R. J.

    2009-01-01

    In rat kidney, real-time PCR revealed a 46-fold Kim-1 gene upregulation after 4 h of brain death. In situ hybridization showed proximal tubular Kim-1 localization, which was confirmed by immunohistochemistry. Also, Luminex assay showed a 6.6-fold Kim-1 rise in urine after 4 h of brain death. In huma

  7. Reference: ABREATCONSENSUS [PLACE

    Lifescience Database Archive (English)

    Full Text Available ABREATCONSENSUS Choi HI, Park HJ, Park JH, Kim S, Im MY, Seo HH, Kim YW, Hwang I, Kim SY.... of Abscisic Acid-Responsive Gene Expression, and Modulates Its Activity. Plant Physiol. 139: 1750-1761(2005) PubMed: 16299177 ...

  8. Producing a Documentary in the Third Grade: Reaching All Students through Movie Making

    Science.gov (United States)

    Fehn, Bruce; Heckart, Kimberly

    2013-01-01

    This article details the work of third grade teacher, co-author Kim Heckart, as she engaged her students in making historical documentaries: a project that succeeded in reaching all of her third-grade students. For the last five years, Kim has required students to make historical documentaries. As her students produced these works, Kim conversed…

  9. TRA LA MONDO

    Institute of Scientific and Technical Information of China (English)

    Nova; tragika; mistifiko

    2000-01-01

    Nova tragika mistifikoLa jusesinta milito en Jugoslavio estaskroma,nova pruvo kiel la tutmondaj,"opin-iokanaligantoj"(Kiel ilin difinas Rejna deJong)ankoraǔfoje sukcesis perforti la veron,mistifiki kaj kretenigi la homaron,por klopodikonvinkiin pri la justeco kaj neeviteblo de mili-

  10. Antropologische Ontmoetingen

    NARCIS (Netherlands)

    Rutten, M.

    2015-01-01

    In deze verzameling columns laat Mario Rutten zien hoe zijn opleiding tot antropoloog zijn relatie met mensen gevormd heeft én hoe hij zelf weer van elke ontmoeting leert. Hij verhaalt van mensen uit de deelstaat Gujarat in Noord-West India die hij als jonge onderzoeker leerde kennen. Die Gujarati’s

  11. Transmissie van Mycobacterium bovis tussen mens en dier

    NARCIS (Netherlands)

    Vries, de G.; Beer, de J.; Bakker, D.; Soolingen, D.

    2015-01-01

    Nederland is officieel vrij van rundertuberculose. Toch komt af en toe nog Mycobacterium bovis-tuberculose voor bij relatief jonge autochtone Nederlanders. Ook zijn er recent nog wel boviene-uitbraken geweest. Dat roept de vraag op of er ook nu nog transmissie is van M.bovis tussen mens en dier. Daa

  12. Teacher competencies for working with young talent : Part 2: Integration of arts disciplines

    NARCIS (Netherlands)

    Kors, Ninja; Rickels, Horst; Smilde, Rineke; Verkuil, Marinus

    2007-01-01

    Twenty sixteen year old fourth-graders of the School for Young Talent (School voor Jong Talent) in The Royal Academy of Fine Arts, Design, Music and Dance (Hogeschool van Beeldende Kunsten, Muziek en Dans) participated in a pilot project that combined music, dance and visual arts in a creative proce

  13. Teacher competencies for working with young talent

    NARCIS (Netherlands)

    Kors, Ninja; Mak, Peter; Smilde, Rineke; Verkuil, Marinus

    2007-01-01

    Twenty sixteen year old fourth-graders of the School for Young Talent (School voor Jong Talent) in The Royal Academy of Fine Arts, Design, Music and Dance (Hogeschool van Beeldende Kunsten, Muziek en Dans) participated in a pilot project that combined music, dance and visual arts in a creative proce

  14. The KGB in Eastern Europe during the Cold War: on agents and confidential contacts

    NARCIS (Netherlands)

    de Jong, B.

    2005-01-01

    Ben de Jong from the University of Amsterdam, Netherlands, discusses the ways in which the KGB collected information about political developments in Eastern Europe during the Cold War and tries to shed some light on the question whether Soviet intelligence services recruited full-fledged agents to a

  15. Grooming: over meerderjarigen die internet en jeugdigen misbruiken

    NARCIS (Netherlands)

    Lodder, A.R.

    2015-01-01

    Betoogd wordt dat de intentie van de dader bij grooming een nadrukkelijker rol zou moeten spelen dan thans het geval is. Het internet is voor jong en oud een plek waar veel tijd wordt doorgebracht. Zoals bekend beperken internetgebruikers zich niet tot goedaardige mensen, maar wordt cyberspace ook b

  16. Using Innovative Outliers to Detect Discrete Shifts in Dynamics in Group-Based State-Space Models

    Science.gov (United States)

    Chow, Sy-Miin; Hamaker, Ellen L.; Allaire, Jason C.

    2009-01-01

    Outliers are typically regarded as data anomalies that should be discarded. However, dynamic or "innovative" outliers can be appropriately utilized to capture unusual but substantively meaningful shifts in a system's dynamics. We extend De Jong and Penzer's 1998 approach for representing outliers in single-subject state-space models to a…

  17. Monitoring the entry of young people into labour market: the potential of the EU-LFS

    NARCIS (Netherlands)

    Berkhout, P.H.G.; Berkhout, E.E.; Biermans, M.L.; van der Valk, J.

    2006-01-01

    Om beter zicht te krijgen op de toetreding van jonge mensen op de arbeidsmarkt in de EU is er in de 'EU Labour Force Study 2000' een ad hoc module geïntroduceerd. Deze module, 'School-To-Work Transition', staat in 2009 opnieuw gepland. Vooruitlopend hierop is SEO Economisch Onderzoek door Eurostat g

  18. Aquacultuur in Mexico.

    NARCIS (Netherlands)

    García Ortega, A.; Leenstra, S.H.

    1997-01-01

    In Mexico is visteelt nog een jonge bedrijfstak. Pas in de tweede helft van deze eeuw werden de eerste commerciële viskwekerijen opgezet. Vanwege de economische voordelen van de visteelt werden veel extensieve visteeltprojecten opgezet als een alternatief voor de visserij. Vanaf de jaren '80 wordt m

  19. Democracy, globalization and ethnic violence

    NARCIS (Netherlands)

    Bezemer, D.J.; Jong-A-Pin, R.

    2013-01-01

    Bezemer, Dirk, and Jong-A-Pin, Richard Democracy, globalization and ethnic violence Do democratization and globalization processes combine to increase the incidence of violence in developing and emerging economies? The present paper examines this hypothesis by a study of internal violence in Sub-Sah

  20. On the molecular genetic etiology of osteosarcoma : gene expression in osteoblasts, osteosarcoma cell lines and osteosarcoma tumours

    NARCIS (Netherlands)

    Wilkens, Martje

    2006-01-01

    Een bottumor, een ‘osteosarcoom’, komt meestal voor bij jonge kinderen en tieners. Marga Wilkens wist in haar promotieonderzoek meer inzicht te krijgen in de achterliggende genetische afwijkingen die ten grondslag liggen aan de ontwikkeling van botkanker. Bij botkanker ondergaan de cellen die normaa

  1. Vergelijking van drie soja-eiwitten (Soycomil P, HP300 en LodeStar ProFa) in biggenvoeders

    NARCIS (Netherlands)

    Rodenburg, T.B.; Krimpen, van M.M.; Binnendijk, G.P.; Bruininx, E.M.A.M.; Mulder, A.

    2004-01-01

    Sojaschroot bevat bepaalde antinutritionele factoren (ANF's), waardoor men deze grondstof beperkt kan opnemen in voeders voor jonge biggen. Door ontvette sojaflakes een specifieke behandeling te geven is het mogelijk het ANF-gehalte te verlagen of de effecten van ANF's te verminderen, zodat een

  2. Changing Stereotype of Jewish Women in the Popular Culture.

    Science.gov (United States)

    Frankel, Judith; Mirsky, Norman

    The stereotype of the Jewish woman as presented in the media--either a female who controls through guilt and is overly concerned with food, or a woman who is an exotic, seductive individual torn between devotion to family and pursuit of private romantic goals--is discussed in this paper. Books by Norman Mailer, John Updike, Erica Jong and Philip…

  3. A Contextualised Multi-Platform Framework to Support Blended Learning Scenarios in Learning Networks

    NARCIS (Netherlands)

    De Jong, Tim; Fuertes, Alba; Schmeits, Tally; Specht, Marcus; Koper, Rob

    2008-01-01

    De Jong, T., Fuertes, A., Schmeits, T., Specht, M., & Koper, R. (2009). A Contextualised Multi-Platform Framework to Support Blended Learning Scenarios in Learning Networks. In D. Goh (Ed.), Multiplatform E-Learning Systems and Technologies: Mobile Devices for Ubiquitous ICT-Based Education (pp. 1-1

  4. A reference model and technical framework for mobile social software for learning

    NARCIS (Netherlands)

    De Jong, Tim; Specht, Marcus; Koper, Rob

    2008-01-01

    De Jong,T., Specht, M., & Koper, R. (2008). A reference model and technical framework for mobile social software for learning. In I. A. Sánchez & P. Isaías (Eds.), Proceedings of the IADIS Mobile Learning Conference 2008 (pp. 206-210). April, 11-13, 2008, Carvoeiro, Portugal.

  5. De brand in Waalre: crisis- en business continuity management

    NARCIS (Netherlands)

    Arts, Kees; Duin, Menno van; Son, Berry van

    2013-01-01

    Hoofdstuk 9 in 'Lessen uit crises en mini-crises 2012' van Duin, van M., Wijkhuijs, V. en Jong, W. (red.) (p. 139-149). In de nacht van dinsdag op woensdag 18 juli 2012 brandt het gemeentehuis van Waalre (gelegen in de buurt van Eindhoven) volledig uit na een opzettelijke brandstichting. Rond drie

  6. On the molecular genetic etiology of osteosarcoma : gene expression in osteoblasts, osteosarcoma cell lines and osteosarcoma tumours

    NARCIS (Netherlands)

    Wilkens, Martje

    2006-01-01

    Een bottumor, een ‘osteosarcoom’, komt meestal voor bij jonge kinderen en tieners. Marga Wilkens wist in haar promotieonderzoek meer inzicht te krijgen in de achterliggende genetische afwijkingen die ten grondslag liggen aan de ontwikkeling van botkanker. Bij botkanker ondergaan de cellen die

  7. Bestrijding van rouwmuggen en oevervliegen

    NARCIS (Netherlands)

    Pijnakker, J.; Leman, A.; Messelink, G.J.; Grosman, A.H.; Holstein, van R.

    2011-01-01

    Rouwmuggen zijn zeer algemeen in kassen, en meestal talrijker dan de typische plaag-insecten. De meeste soorten voeden zich met schimmels en met organisch materiaal, en zijn onschadelijke voor planten. Enkele soorten kunnen schadelijk zijn in zaaibedden, aan stekmateriaal en aan jonge planten. Veel

  8. Preclinical Studies of Induced Pluripotent Stem Cell-Derived Astrocyte Transplantation in ALS

    Science.gov (United States)

    2014-12-01

    de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH, Jr...lumbar safety outcomes. Neurosurgery 71:405-416; discussion 416. Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D

  9. Development of Repeated Sprint Ability in Talented Youth Basketball Players

    NARCIS (Netherlands)

    te Wierike, Sanne C. M.; de Jong, Mark C.; Tromp, Eveline J. Y.; Vuijk, Pieter J.; Lemmink, Koen A. P. M.; Malina, Robert M.; Elferink-Gemser, Marije T.; Visscher, Chris

    te Wierike, SCM, de Jong, MC, Tromp, EJY, Vuijk, PJ, Lemmink, KAPM, Malina, RM, Elferink-Gemser, MT, and Visscher, C. Development of repeated sprint ability in talented youth basketball players. J Strength Cond Res 28(4): 928-934, 2014-Factors affecting repeated sprint ability (RSA) were evaluated

  10. Cross-contamination in the kitchen: estimation of transfer rates for cutting boards, hands and knives

    NARCIS (Netherlands)

    Asselt, van E.D.; Jong, de A.E.I.; Jonge, de R.; Nauta, M.J.

    2008-01-01

    Aims: To quantify cross-contamination in the home from chicken to readyto-eat salad. Methods and Results: Based on laboratory scenarios performed by de Jong et al. (2008), transfer rates were estimated for Campylobacter jejuni and Lactobacillus casei as a tracer organism. This study showed that tran

  11. Identification and characterization of Brucella effector proteins

    NARCIS (Netherlands)

    de Jong, Maarten Frederik

    2012-01-01

    Brucella-bacteriën gebruiken de eiwitten VceB en VceC om het immuunsysteem van humane gastheercellen te omzeilen, blijkt uit het promotieonderzoek van Maarten de Jong. Dit biedt nieuwe aanknopingspunten voor de bestrijding van deze gevaarlijke bacterie. Brucellose is een wereldwijd voorkomende ziekt

  12. A Necessary Moment Condition for the Fractional Central Limit Theorem

    DEFF Research Database (Denmark)

    Johansen, Søren; Nielsen, Morten

    2012-01-01

    /2) moments are necessary for more general fractional processes. Davidson and de Jong (2000, Econometric Theory 16, 643-- 666) presented a fractional FCLT where onlyq>2 finite moments are assumed. As a corollary to our main theorem we show that their moment condition is not sufficient and hence...

  13. Educator Language Ideologies and a Top-Down Dual Language Program

    Science.gov (United States)

    Fitzsimmons-Doolan, Shannon; Palmer, Deborah; Henderson, Kathryn

    2017-01-01

    Dual language bilingual education (DLBE) programs are framed to reflect pluralist discourses (de Jong, E. [2013]. "Policy Discourses and U.S. Language in Education Policies." "Peabody Journal of Education" 88 (1): 98-111) and affiliated language ideologies. The continued expansion of DLBE programs not surprisingly brings to…

  14. Het geluid van de Beatles. Een muzieksociologische studie

    NARCIS (Netherlands)

    Tillekens, Gerardus Jacobus

    1998-01-01

    Het geluid van de Beatles. Er valt niet veel meer aan te doen. Met een soort emotionele superlijm zit het geluid van de Beatles en al die andere groepen van de Britse beatexplosie voor altijd verkleefd aan het beeld van de jaren zestig. Voor velen, zowel jong als oud kwam dat moment van culturele ve

  15. Genetica en beweging – De moeite waard om te leren

    NARCIS (Netherlands)

    Jong, de J.H.S.G.M.

    2012-01-01

    Het tiende boek in de NVON-reeks heeft als titel Genetica in beweging, de moeite waard om te leren. Op 25 april 2012 zal dit boek worden gepresenteerd tijdens een studiemiddag. Ter gelegenheid daarvan heeft prof. Hans de Jong het volgende artikel voor NVOX geschreven.

  16. De vrolijke planner

    NARCIS (Netherlands)

    Duineveld, M.; Ark, van R.G.H.; Assche, van K.A.M.

    2005-01-01

    Een groep jonge onderzoekers bij ruimtelijke planvorming (Wageningen Universiteit) vertolkte de afgelopen jaren een postmodern gedachtegoed. Met dit essay betogen zij dat er iets moet veranderen. Het artikel wil een aanzet tot kritisch denken zijn, dat vèrder gaat dan de inhoud van verplichte vakken

  17. Plant-maps for the Netherlands 1:3.000.000. Part I. Compiled by „The Institute for the Investigation of the Vegetation in the Netherlands” (I.V.O.N.)

    NARCIS (Netherlands)

    NN,

    1935-01-01

    This publication is a continuation of „Plantenkaartjes voor Nederland”, published by Dr. J. W. C. GOETHART and Dr. W. J. JONG MANS in the years 1902—1908. For both publications the same methods, differing in two respects from those usually adopted elsewhere, have been employed. As in the first place

  18. Always Becoming: (De-) (Re-)territorializing : A Social Studies Autoethnography as 'Minor Literature'

    NARCIS (Netherlands)

    Jong, J.B.M. de

    2014-01-01

    In Always Becoming: (De-) (Re-)territorializing, De Jong begins to construct her work from the premise that identity is relational, by which she means that she views processes of identity formation not as the fixed result of a subject acting upon an inert object, but rather as interactional and nego

  19. De Ratio van Corporate Governance

    NARCIS (Netherlands)

    A. de Jong (Abe)

    2006-01-01

    textabstractAbe de Jong (1970) is Professor in Corporate Finance and Corporate Governance at RSM Erasmus University. He obtained a PhD in finance at Tilburg University (1999). His research and teaching interests are in the area of empirical corporate finance and include capital structure choice,

  20. Effect van kruiden en kuikenkwaliteit op de respons van biologische leghenkuikens na een coccidiosebesmetting = Effect of herbal treatments and chick quality on the response of young organic layer poults after infection with coccidiosis

    NARCIS (Netherlands)

    Lourens, A.; Jongbloed, A.W.

    2008-01-01

    De effecten van kruiden en kuikenkwaliteit op de respons van jonge biologische opfokhennen op een coccidiose besmetting was onderzocht. Kruiden hadden geen effect op de laesie scores of op technische resultaten. Kuikenkwaliteit had ook geen effect op laesie scores, maar had wel een significant effec

  1. On the molecular genetic etiology of osteosarcoma : gene expression in osteoblasts, osteosarcoma cell lines and osteosarcoma tumours

    NARCIS (Netherlands)

    Wilkens, Martje

    2006-01-01

    Een bottumor, een ‘osteosarcoom’, komt meestal voor bij jonge kinderen en tieners. Marga Wilkens wist in haar promotieonderzoek meer inzicht te krijgen in de achterliggende genetische afwijkingen die ten grondslag liggen aan de ontwikkeling van botkanker. Bij botkanker ondergaan de cellen die normaa

  2. Young men in a colourful city: Masculinity, young men's sexual practices, and HIV/AIDS in Dhaka, Bangladesh

    NARCIS (Netherlands)

    Imtiaz, S.M.S.

    2012-01-01

    Saikh Imtiaz onderzocht de relatie tussen hiv/aids, mannelijke hegemonie en seksualiteit in Dhaka, Bangladesh. Deze in de ogen van jonge mannen 'kleurrijke' stad verschaft veel vrijheden, ook op seksueel gebied. Het heersende ideaalbeeld van de succesvolle man (sofol purush) representeert voor veel

  3. Topological Insulators and Superconductors for Innovative Devices

    Science.gov (United States)

    2015-03-20

    and Technology (OIST), Okinawa, May 14, 2014. 6. Yoichi Ando, “Superconducting Topological Insulators”, Theo Murphy International Scientific...D.; Hor, Y. S.; Cava, R. J.; Hasan, M. Z. Nat. Phys. 2009, 5, 398−402. (20) Dash, S. P.; Sharma, S.; Patel, R. S.; Jong, M. P.; Jansen , R. Nature

  4. Coping with stressors in late adolescence/young adulthood: a salutogenic perspective

    Directory of Open Access Journals (Sweden)

    Hester G Pretorius

    2007-03-01

    Full Text Available Literature indicates that globally young people are increasingly experiencing life as hopeless and meaningless. Opsomming Literatuur dui aan dat alhoemeer jong volwassenes hulle lewens as leeg en betekenloos ervaar. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

  5. Ethics in action: Approving and improving medical research with human subjects

    NARCIS (Netherlands)

    J.P. de Jong

    2013-01-01

    In this thesis, Jean Philippe de Jong presents a new understanding of ethical oversight on medical research with human subjects and proposes that two philosophies for ethical oversight exist: '(dis)approving' and 'improving'. Systems for ethical oversight on medical research have been in place for m

  6. Leeftijd van zelfstandig eten bij papegaaien : literatuur onderzoek = Weaning ages in parrot species

    NARCIS (Netherlands)

    Koene, P.

    2014-01-01

    Jonge papegaaien kunnen van hun ouders gescheiden worden, wanneer ze zelfstandig eten. De leeftijd waarop verschilt tussen soorten. Gebaseerd op geschreven bronnen is voor alle soorten papegaaien een lijst van deze leeftijden gemaakt.Young parrots can be separated safely from their parents when they

  7. The intake of acrylamide, nitrate and ochratoxin A in people aged 7 to 69 living in the Netherlands

    NARCIS (Netherlands)

    Geraets L; te Biesebeek JD; van Donkersgoed G; Koopman N; Boon PE; VVH; V& Z

    2014-01-01

    De voeding van kinderen (7-15 jaar) en (jong) volwassenen (16-69 jaar) in Nederland is veilig wat betreft de inname van nitraat, dat vooral in groenten zit. De hoeveelheid acrylamide waaraan beide leeftijdsgroepen worden blootgesteld via de voeding zou mogelijk schadelijk kunnen zijn voor de gezondh

  8. Riskant verkeersgedrag onder pubers.

    NARCIS (Netherlands)

    2012-01-01

    De adolescentie is de periode tussen kindertijd en volwassenheid. Vergeleken met oudere adolescenten (18-24 jaar) gedragen jonge adolescenten (pubers van 10-17 jaar) zich riskanter. Door hun lichamelijke en geestelijke ontwikkeling zijn pubers meer aangetrokken tot gevaarlijke uit-dagingen, gevoelig

  9. Verkeersmortaliteit en achtergronden van riskant verkeersgedrag in de vroege adolescentie.

    NARCIS (Netherlands)

    Twisk, D.

    2015-01-01

    Jonge adolescenten in de leeftijd 10 tot 17 jaar hebben nog geen rijbewijs B, mogen vanaf hun 16de het rijbewijs AM 1 halen en verplaatsen zich meestal als voetganger, fietser en autopassagier. Recent hersenonderzoek wijst uit dat - in vergelijking tot oudere adolescenten (18 tot 24 jaar) - de leeft

  10. Vocational education in the Netherlands: in search of a new identity

    NARCIS (Netherlands)

    Dr. Jan Geurts; dr. Frans Meijers

    2007-01-01

    When the Netherlands developed a national system of vocational education at the end of the 19th century, it was a direct answer to obvious shortcomings in the technical and trade professions (De Jonge, 1968). It concentrated on training craftsmen for the traditional, mainly agrarian economy, and

  11. Frogs and snakes from the island of Morotai (Moluccas)

    NARCIS (Netherlands)

    Brongersma, L.D.

    1948-01-01

    Van Kampen (1924, p. 284) mentions only two species of frogs from Morotai Island; the identification of one of these was considered to be doubtful. Of snakes De Jong (1928, p. 149) records five species from this island. The study of a small collection of frogs and snakes from Morotai, presented to t

  12. The Value of Story in Medicine and Medical Education: A Chance to Reflect

    Science.gov (United States)

    Clarke, Linda E.; de Jong, Jennifer D.

    2012-01-01

    While JJ was a medical student, the authors worked on a two-part study of the stories of "good death" as they were told by palliative care patients, caregivers, physicians and nurses. In this personal reflection, de Jong (JJ), now a family practitioner and Clarke (LC), an artist and educator in medicine and health care, consider the value of such…

  13. Identification and characterization of Brucella effector proteins

    NARCIS (Netherlands)

    de Jong, Maarten Frederik

    2012-01-01

    Brucella-bacteriën gebruiken de eiwitten VceB en VceC om het immuunsysteem van humane gastheercellen te omzeilen, blijkt uit het promotieonderzoek van Maarten de Jong. Dit biedt nieuwe aanknopingspunten voor de bestrijding van deze gevaarlijke bacterie. Brucellose is een wereldwijd voorkomende

  14. Written Corrective Feedback and Peer Review in the BYOD Classroom

    Science.gov (United States)

    Ferreira, Daniel

    2013-01-01

    Error correction in the English as a Foreign Language (EFL) writing curriculum is a practice both teachers and students agree is important for writing proficiency development (Ferris, 2004; Van Beuningen, De Jong, & Kuiken, 2012; Vyatkina, 2010, 2011). Research suggests student dependency on teacher corrective feedback yields few long-term…

  15. Inventarisatie afrasteringen tegen hazen

    NARCIS (Netherlands)

    Spruijt, J.; Uijthoven, W.; Wijk, van K.

    2007-01-01

    Wildschade vormt een groot probleem. De kosten van wildschade nemen ieder jaar aanzienlijk toe. Omdat schade in vollegrondsgroentenvooral bij jonge planten voorkomt is (tijdelijke) afrastering mogelijk een goedafweermiddel tegen hazen. Er zijn diverse soorten systemen van afrastering in de handel, w

  16. Cross-contamination in the kitchen: estimation of transfer rates for cutting boards, hands and knives

    NARCIS (Netherlands)

    Asselt, van E.D.; Jong, de A.E.I.; Jonge, de R.; Nauta, M.J.

    2008-01-01

    Aims: To quantify cross-contamination in the home from chicken to readyto-eat salad. Methods and Results: Based on laboratory scenarios performed by de Jong et al. (2008), transfer rates were estimated for Campylobacter jejuni and Lactobacillus casei as a tracer organism. This study showed that

  17. Development of Repeated Sprint Ability in Talented Youth Basketball Players

    NARCIS (Netherlands)

    te Wierike, Sanne C. M.; de Jong, Mark C.; Tromp, Eveline J. Y.; Vuijk, Pieter J.; Lemmink, Koen A. P. M.; Malina, Robert M.; Elferink-Gemser, Marije T.; Visscher, Chris

    2014-01-01

    te Wierike, SCM, de Jong, MC, Tromp, EJY, Vuijk, PJ, Lemmink, KAPM, Malina, RM, Elferink-Gemser, MT, and Visscher, C. Development of repeated sprint ability in talented youth basketball players. J Strength Cond Res 28(4): 928-934, 2014-Factors affecting repeated sprint ability (RSA) were evaluated i

  18. Bestrijden en voorkomen van de oculatieschimmel Black Mold in roos

    NARCIS (Netherlands)

    Werd, de H.A.E.; Breeuwsma, S.J.; Meijer, H.; Wijk, van D.; Pijpers, H.

    2008-01-01

    Black Mold veroorzaakt afsterving van jonge oculaties in de teelt van rozenstruiken. Middels een enquête onder telers, een korte literatuurstudie en infectieproeven is een inventariserend onderzoek gedaan naar de factoren die het optreden van Black Mold beïnvloeden. Op basis van de infectieproeven i

  19. Die bydrae van prof. J.A. van Rooy in kerk, koninkryk, sending en teologie

    OpenAIRE

    F. Buys

    1998-01-01

    Jacobus Albertus van Rooy is op 25 Julie 1932 te Ventersburg gebore as die seun van ds. en mev. Jacs van Rooy. Sy moeder is oorlede toe hy nog ’n jong seun was. Hy het skoolgegaan op Brits en Pietersburg en later aan die PU vir CHO sy tersiêre opleiding ondergaan, terwyl hy hom voorberei het om predikant te word.

  20. Every Word You Speak

    Science.gov (United States)

    Colburn, Alan; Nguyen, Huong Tran

    2012-01-01

    More than five million U.S. students are English language learners (ELLs), or 57% more than a decade ago. If that growth continues, sooner or later, all teachers will teach ELLs. But many teachers are unprepared for this challenge. They might presume that "good teaching" helps ELLs learn content (de Jong and Harper 2008) or that an English-only…