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Sample records for hw sw cpr

  1. The Importance of Interfaces: A HW/SW Codesign Case Study

    DEFF Research Database (Denmark)

    Jensen, Dan C. Raun; Madsen, Jan; Pedersen, Steen

    1997-01-01

    This paper presents a codesign case study in image analysis. The main objective is to stress the importance of handling HW/SW interfaces more precisely at the system level. In the presented case study, there is an intuitive and simple HW/SW interface, which is based upon the functional modules in...... in the application. However, it is found that this seemingly sound choice caused a number of practical problems and sub-optimal solutions during the implementation of the prototype system....

  2. Simulink-based HW/SW codesign of embedded neuro-fuzzy systems.

    Science.gov (United States)

    Reyneri, L M; Chiaberge, M; Lavagno, L

    2000-06-01

    We propose a semi-automatic HW/SW codesign flow for low-power and low-cost Neuro-Fuzzy embedded systems. Applications range from fast prototyping of embedded systems to high-speed simulation of Simulink models and rapid design of Neuro-Fuzzy devices. The proposed codesign flow works with different technologies and architectures (namely, software, digital and analog). We have used The Mathworks' Simulink environment for functional specification and for analysis of performance criteria such as timing (latency and throughput), power dissipation, size and cost. The proposed flow can exploit trade-offs between SW and HW as well as between digital and analog implementations, and it can generate, respectively, the C, VHDL and SKILL codes of the selected architectures.

  3. Gesture Recognition Using Neural Networks Based on HW/SW Cosimulation Platform

    Directory of Open Access Journals (Sweden)

    Priyanka Mekala

    2013-01-01

    Full Text Available Hardware/software (HW/SW cosimulation integrates software simulation and hardware simulation simultaneously. Usually, HW/SW co-simulation platform is used to ease debugging and verification for very large-scale integration (VLSI design. To accelerate the computation of the gesture recognition technique, an HW/SW implementation using field programmable gate array (FPGA technology is presented in this paper. The major contributions of this work are: (1 a novel design of memory controller in the Verilog Hardware Description Language (Verilog HDL to reduce memory consumption and load on the processor. (2 The testing part of the neural network algorithm is being hardwired to improve the speed and performance. The American Sign Language gesture recognition is chosen to verify the performance of the approach. Several experiments were carried out on four databases of the gestures (alphabet signs A to Z. (3 The major benefit of this design is that it takes only few milliseconds to recognize the hand gesture which makes it computationally more efficient.

  4. A HW-SW Co-Designed System for the Lunar Lander Hazard Detection and Avoidance Breadboarding

    Science.gov (United States)

    Palomo, Pedro; Latorre, Antonio; Valle, Carlos; Gomez de Aguero, Sergio; Hagenfeldt, Miguel; Parreira, Baltazar; Lindoso, Almudena; Portela, Marta; Garcia, Mario; San Millan, Enrique; Zharikov, Yuri; Entrena, Luis

    2014-08-01

    This paper presents the HW-SW co-design approach followed to tackle the design of the Hazard Detection and Avoidance (HDA) system breadboarding for the Lunar Lander ESA mission, undertaken given the fact that novel GNC technologies used to promote autonomous systems demand processing capabilities that current (and forthcoming) space processors are not able to satisfy. The paper shows how the current system design has been performed in a process in which the original HDA functionally validated design has been partitioned between SW (deemed for execution in a microprocessor) and HW algorithms (to be executed in an FPGA), considering the performance requirements and resorting to a deep analysis of the algorithms in view of their adequacy to HW or SW implementation.

  5. Use of Student Experiments for Teaching Embedded Software Development Including HW/SW Co-Design

    Science.gov (United States)

    Mitsui, H.; Kambe, H.; Koizumi, H.

    2009-01-01

    Embedded systems have been applied widely, not only to consumer products and industrial machines, but also to new applications such as ubiquitous or sensor networking. The increasing role of software (SW) in embedded system development has caused a great demand for embedded SW engineers, and university education for embedded SW engineering has…

  6. Four-colour photometry of eclipsing binaries. XLI uvby light curves for AD Bootis, HW Canis Majoris, SW Canis Majoris, V636 Centauri, VZ Hydrae, and WZ Ophiuchi

    CERN Document Server

    Clausen, J V; García, J M; Giménez, A; Helt, B E; Olsen, E H; Andersen, J

    2008-01-01

    CONTEXT: Accurate mass, radius, and abundance determinations from binaries provide important information on stellar evolution, fundamental to central fields in modern astrophysics and cosmology. AIMS: Within the long-term Copenhagen Binary Project, we aim to obtain high-quality light curves and standard photometry for double-lined detached eclipsing binaries with late A, F, and G type main-sequence components, needed for the determination of accurate absolute dimensions and abundances, and for detailed comparisons with results from recent stellar evolutionary models. METHODS: Between March 1985 and July 2007, we carried out photometric observations of AD Boo, HW CMA, SW CMa, V636 Cen, VZ Hya, and WZ Oph at the Str"omgren Automatic Telescope at ESO, La Silla. RESULTS: We obtained complete uvby light curves, ephemerides, and standard uvby\\beta indices for all six systems.For V636 Cen and HW CMa, we present the first modern light curves, whereas for AD Boo, SW CMa, VZ Hya, and WZ Oph, they are both more accurate...

  7. CPR - infant

    Science.gov (United States)

    ... breathing and chest compressions - infant; Resuscitation - cardiopulmonary - infant; Cardiopulmonary resuscitation - infant ... CPR is best done by someone trained in an accredited CPR course. The newest techniques emphasize compression ...

  8. GRT:a High-Performance Customizable HW/SW Open Platform for Underlying Wireless Networks%GRT:高性能可定制无线网络底层软硬件开放平台

    Institute of Scientific and Technical Information of China (English)

    吴浩洋; 王韬; 陈佳华; 龚健; 李晓光; 张高瀚; 吕松武

    2015-01-01

    随着无线技术的飞速发展,无线领域的研发者和特殊需求的使用者亟需一种高性能、可定制的无线网络底层软硬件平台。本文介绍了自主设计并实现的GRT平台,能够提供高性能、高可定制性、高兼容性与开放性的特征。作为示例,已经在GRT系统上实现了一套基于802.11a/g协议的软/硬件代码,性能超过了协议标准中对于物理层最大速率的要求,且能够与商用WiFi设备进行互通。%With the rapid development of wireless technology, wireless developers and users for special needs require a high-performance, customizable hardware/software(HW/SW) open platform for underlying wireless networks. This paper describes the design and implement of our proposed GRT platform, which can provide the features of high-performance, highly customizability, compatibility, and openness. As an example, we have implemented a set of SW/HW codes following 802.11a/g protocol. The system based on these codes exceeds the maximum data rate of the physical layer specified in the protocol, and can communicate with commodity WiFi devices.

  9. CPR Drilling.

    Science.gov (United States)

    Kittleson, Mark

    1980-01-01

    Problems encountered by cardiopulmonary resuscitation (CPR) instructors are discussed and some possible solutions to these problems are suggested. Management techniques for effective use of class size, time, and instructional materials are described. (JN)

  10. CPR: Infant

    Medline Plus

    Full Text Available Refresher Center Home FIRST AID, CPR and AED LIFEGUARDING Refresher Putting It All Together: CPR—Infant (1:52) Refresher videos only utilize this player QUICK LINKS Home ...

  11. CPR: Adult

    Medline Plus

    Full Text Available ... AID, CPR and AED LIFEGUARDING Refresher Putting It All Together: CPR—Adult (2:03) Refresher videos only ... Store Contact Us Privacy Policy Terms and Conditions All rights reserved. 2011 American National Red Cross.

  12. CPR: Infant

    Medline Plus

    Full Text Available ... AID, CPR and AED LIFEGUARDING Refresher Putting It All Together: CPR—Infant (1:52) Refresher videos only ... Store Contact Us Privacy Policy Terms and Conditions All rights reserved. 2011 American National Red Cross.

  13. SW/HW co-simulation system for USB2.0 master controller%USB2.0主控器软硬件协同仿真系统设计

    Institute of Scientific and Technical Information of China (English)

    李金亭; 刘卫东

    2012-01-01

    A SW/HW co-simulation platform was designed for the sufficient and rapid verification of USB2. 0 master controller. In this platform, an efficient SystemC model is adopted for CPU model instead of the instruction set based complex CPU model. Test cases are writen with the higher abstraction level C language, which performs the stimulus generation and response checking through calling the API provided by the simulation platform. The simulation result shows that this method can effectively reduce the occupation of simulation resource and the simulation time. Meanwhile, it enables the software designers to fulfil the software debugging in hardware verification phase, so as to shorten the integration time of hardware and software interfaces, and speed up the development of the project.%为了能够充分、快速验证USB 2.0主控器的功能,设计了一个软硬件协同仿真平台.其中,CPU模型部分采用一种高效的SystemC模型,而不使用基于指令集的复杂CPU模型.测试用例采用抽象层次更高的C语言编写,通过调用仿真平台对外提供的API完成激励生成与响应检查.结果表明,该方式能够有效降低对仿真资源的占用,减少仿真时间;同时使软件人员能在IP的硬件验证阶段就能完成软件的设计测试工作,缩短软硬件接口整合时间,加快开发进度.

  14. CPR (For Parents)

    Science.gov (United States)

    ... Your Child Natural Disasters: How Families Can Help CPR KidsHealth > For Parents > CPR Print A A A ... can be given by health care providers. About CPR CPR (or cardiopulmonary resuscitation ) is a combination of ...

  15. CPR: Infant

    Medline Plus

    Full Text Available Refresher Center Home FIRST AID, CPR and AED LIFEGUARDING Refresher Putting It All Together: CPR—Infant (1:52) Refresher videos only utilize this player QUICK LINKS Home RedCross.org Purchase Course Materials Shop Our Store ...

  16. CPR: Adult

    Medline Plus

    Full Text Available Refresher Center Home FIRST AID, CPR and AED LIFEGUARDING Refresher Putting It All Together: CPR—Adult (2:03) Refresher videos only utilize this player QUICK LINKS Home RedCross.org Purchase Course Materials Shop Our Store ...

  17. Combined HW/SW Reliability Models.

    Science.gov (United States)

    1982-04-01

    Stone, C. J. (1972). Introduction to Stochastic Processes . New York: Houghton Mifflin. Jelinski, Z. and Moranda, P. (1972). Software reliability...research. Statistical Computer Performance Evaluation, New York: Academic Press, 465-484. Kannan, D. (1979). An Introduction to Stochastic Processes . New

  18. International CPR guidelines - perspectives in CPR.

    Science.gov (United States)

    Nolan, Jerry P

    2013-09-01

    The International Liaison Committee on Resuscitation (ILCOR) co-ordinates regular reviews of cardiopulmonary resuscitation (CPR) science and publishes consensus on science statements and treatment recommendations. These outputs are used by international resuscitation organisations to generate clinical guidelines. This review will outline the history behind the development of international CPR guidelines and will provide a detailed description of the current guideline generating process. A perspective is provided on the future of this process and the prospects for completely unified international CPR guidelines.

  19. Potential Degradation of Swainsonine by Intracellular Enzymes of Arthrobacter sp. HW08

    Directory of Open Access Journals (Sweden)

    Haili Li

    2013-11-01

    Full Text Available Swainsonine (SW is a toxin produced by locoweeds and harmful to the livestock industry. Degrading SW by Arthrobacter sp. HW08 was demonstrated as a promising way to deal with SW poisoning. However, it is unknown which part of the subcellular enzymes in Arthrobacter sp. HW08 is responsible for biodegrading SW and whether the metabolites are atoxic. In this study, intracellular and extracellular enzymes of Arthrobacter sp. HW08 were isolated and their enzyme activity was evaluated. The metabolites were fed to mice, and physiological and histological properties of the treated mice were investigated. The results showed that only intracellular enzyme of Arthrobacter sp. HW08 (IEHW08 could degrade SW efficiently. Compared with mice in SW treatment group, mice in SW + IEHW08 treatment group (1 increased their body weights; (2 showed higher number of platelets and lower number of white blood cells; (3 decreased the levels of creatinine, urea nitrogen, alanine transaminase and aspartate aminotransferase in serum; (4 reduced the number of vacuolated cells in cerebellum, liver and kidney. All these data demonstrate that IEHW08 was potentially safe for mice, while keeping the capacity of degrading SW. This study indicates a possible application of IEHW08 as an additive in the livestock industry to protect animals from SW poisoning.

  20. CPR - adult - slideshow

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/presentations/100219.htm CPR - adult - series—Check for responsiveness To use the ... A.M. Editorial team. Related MedlinePlus Health Topics CPR A.D.A.M., Inc. is accredited by ...

  1. CPR - infant - slideshow

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/presentations/100216.htm CPR - infant - series—Check for responsiveness To use the ... yourself to call 911 until you have performed CPR for about 2 minutes. 3. Carefully place the ...

  2. CPR Facts and Stats

    Science.gov (United States)

    ... Implementation OSHA and AHA Alliance Be The Beat Recursos para hispanohablantes en EE UU CPR & AED Awareness ... Implementation OSHA and AHA Alliance Be The Beat Recursos para hispanohablantes en EE UU CPR & AED Awareness ...

  3. Hands-Only CPR

    Science.gov (United States)

    ... Implementation OSHA and AHA Alliance Be The Beat Recursos para hispanohablantes en EE UU CPR & AED Awareness ... Implementation OSHA and AHA Alliance Be The Beat Recursos para hispanohablantes en EE UU CPR & AED Awareness ...

  4. CPR: Key to Cardiac Consciousness?

    Science.gov (United States)

    Hyner, Gerald C.; Box, Colin E.

    1980-01-01

    Recommendations are made for improving certification standards for programs providing training in cardiopulmonary resuscitation (CPR). Training techniques, cost effectiveness, and teachers for CPR programs are discussed. (JD)

  5. NNLOPS accurate associated HW production

    CERN Document Server

    Astill, William; Re, Emanuele; Zanderighi, Giulia

    2016-01-01

    We present a next-to-next-to-leading order accurate description of associated HW production consistently matched to a parton shower. The method is based on reweighting events obtained with the HW plus one jet NLO accurate calculation implemented in POWHEG, extended with the MiNLO procedure, to reproduce NNLO accurate Born distributions. Since the Born kinematics is more complex than the cases treated before, we use a parametrization of the Collins-Soper angles to reduce the number of variables required for the reweighting. We present phenomenological results at 13 TeV, with cuts suggested by the Higgs Cross Section Working Group.

  6. Codesign Environment for Computer Vision Hw/Sw Systems

    Science.gov (United States)

    Toledo, Ana; Cuenca, Sergio; Suardíaz, Juan

    2006-10-01

    In this paper we present a novel codesign environment which is conceived especially for computer vision hybrid systems. This setting is based on Mathworks Simulink and Xilinx System Generator tools and is comprised of the following: an incremental codesign flow, diverse libraries of virtual components with three levels of description (high level, hardware and software), semi-automatic tools to help in the partition of the system and a methodology for building new library components. The use of high level libraries allows for the development of systems without the need of exhaustive knowledge of the actual architecture or special skills on hardware description languages. This enable a non-traumatic incorporation of the reconfigurable technologies in the image processing systems generally developed for engineers which are not very related to hardware design disciplines.

  7. Smart Camera Based on Embedded HW/SW Coprocessor

    Directory of Open Access Journals (Sweden)

    Dubois Julien

    2008-01-01

    Full Text Available Abstract This paper describes an image acquisition and a processing system based on a new coprocessor architecture designed for CMOS sensor imaging. The system exploits the full potential CMOS selective access imaging technology because the coprocessor unit is integrated into the image acquisition loop. The acquisition and coprocessing architecture are compatible with the majority of CMOS sensors. It enables the dynamic selection of a wide variety of acquisition modes as well as the reconfiguration and implementation of high-performance image preprocessing algorithms (calibration, filtering, denoising, binarization, pattern recognition. Furthermore, the processing and data transfer, from the CMOS sensor to the processor, can be operated simultaneously to increase achievable performances. The coprocessor architecture has been designed so as to obtain a unit that can be configured on the fly, in terms of type and number of chained processing stages (up to 8 successive predefined preprocessing stages, during the image acquisition process that can be defined by the user according to each specific application requirement. Examples of acquisition and processing performances are reported and compared to classical image acquisition systems based on standard modular PC platforms. The experimental results show a considerable increase of the achievable performances.

  8. CPR: A Real Lifesaver (For Kids)

    Science.gov (United States)

    ... Want to Know About Puberty Train Your Temper CPR: A Real Lifesaver KidsHealth > For Kids > CPR: A ... Let's find out how it works. What Is CPR? Cardio means "of the heart " and pulmonary means " ...

  9. Learn CPR You Can Do It!

    Science.gov (United States)

    Have a question about CPR? Click Here To Ask The Doctor Learn CPR is a free public service supported by the University of Washington School of Medicine . Learn the basics of CPR - cardiopulmonary resuscitation. The American Heart Association issued updated ...

  10. Analysis list: su(Hw) [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available su(Hw) Adult,Cell line,Embryo + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/...target/su(Hw).1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/su(Hw).5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/target/su(Hw).10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/su(Hw).Ad...ult.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/su(Hw).Cell_line.tsv,http://dbarchive.bioscien...cedbc.jp/kyushu-u/dm3/colo/su(Hw).Embryo.tsv http://dbarchive.biosciencedbc.jp/kyus

  11. Teaching CPR to Florida's Students.

    Science.gov (United States)

    Varnes, Jill W.; Crone, Ernest G.

    1980-01-01

    A program in cardiopulmonary resuscitation (CPR) instruction for Florida's school children is described. Program guidelines and support services are detailed for other schools wishing to implement such a program. (JN)

  12. Prediction of Recovery from Coma After CPR

    Science.gov (United States)

    ... THEIR FAMILIES PREDICTION OF RECOVERY FROM COMA AFTER CPR This summary will provide you with information about ... help doctors predict poor recovery from coma after CPR. In this case, poor recovery means death, continued ...

  13. Dispatcher instruction of chest compression-only CPR increases actual provision of bystander CPR.

    Science.gov (United States)

    Shimamoto, Tomonari; Iwami, Taku; Kitamura, Tetsuhisa; Nishiyama, Chika; Sakai, Tomohiko; Nishiuchi, Tatsuya; Hayashi, Yasuyuki; Kawamura, Takashi

    2015-11-01

    A preceding randomized controlled trial demonstrated that chest compression-only cardiopulmonary resuscitation (CPR) instruction by dispatcher was more effective to increase bystander CPR than conventional CPR instruction. However, the actual condition of implementation of each type of dispatcher instruction (chest compression-only CPR [CCCPR] or conventional CPR with rescue breathing) and provision of bystander CPR in real prehospital settings has not been sufficiently investigated. This registry prospectively enrolled patients aged =>18 years suffering an out-of-hospital cardiac arrest (OHCA) of non-traumatic causes before emergency-medical-service (EMS) arrival, who were considered as target subjects of dispatcher instruction, resuscitated by EMS personnel, and transported to medical institutions in Osaka, Japan from January 2005 through December 2012. The primary outcome measure was provision of CPR by a bystander. Multiple logistic regression analysis was used to assess factors that were potentially associated with provision of bystander CPR. Among 37,283 target subjects of dispatcher instruction, 5743 received CCCPR instruction and 13,926 received conventional CPR instruction. The proportion of CCCPR instruction increased from 5.7% in 2005 to 25.6% in 2012 (p for trend bystander CPR more frequently than conventional CPR instruction group (70.0% versus 62.1%, pbystander CPR compared with conventional CPR instruction (adjusted odds ratio 1.44, 95% CI 1.34-1.55). CCCPR dispatcher instruction among adult OHCA patients significantly increased the actual provision of bystander CPR. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  14. Analysis of the Capability Portfolio Review (CPR)

    Science.gov (United States)

    2014-06-01

    TRAC-M-TR-14-021 June 2014 Analysis of the Capability Portfolio Review ( CPR ) TRADOC Analysis Center 700...INTENTIONALLY LEFT BLANK TRAC-M-TR-14-021 June 2014 Analysis of the Capability Portfolio Review ( CPR ) Authors LTC Thomas Deveans...4. TITLE AND SUBTITLE Analysis of the Capability Portfolio Review ( CPR ) 5. PROJECT NUMBERS TRAC Project Code 060097 6. AUTHOR(S) LTC Deveans

  15. Evaluating Barriers to Bystander CPR among Laypersons before and after Compression-only CPR Training.

    Science.gov (United States)

    Bouland, Andrew J; Halliday, Megan H; Comer, Angela C; Levy, Matthew J; Seaman, Kevin G; Lawner, Benjamin J

    2017-01-01

    Bystander CPR is an essential part of out-of-hospital cardiac arrest (OHCA) survival. EMS and public safety jurisdictions have embraced initiatives to teach compression-only CPR to laypersons in order to increase rates of bystander CPR. We examined barriers to bystander CPR amongst laypersons participating in community compression-only CPR training and the ability of the training to alleviate these barriers. The barriers analyzed include fear of litigation, risk of disease transmission, fear of hurting someone as a result of doing CPR when unnecessary, and fear of hurting someone as a result of doing CPR incorrectly. Laypersons attending community compression-only CPR training were administered surveys before and after community CPR training. Data were analyzed via standard statistical analyses. A total of 238 surveys were collected and analyzed between September 2015 and January 2016. The most common reported motivation for attending CPR training was "to be prepared/just in case" followed by "infant or child at home." Respondents reported that they were significantly more likely to perform CPR on a family member than a stranger in both pre-and post-training responses. Nevertheless, reported self-confidence in and likelihood of doing CPR on both family and strangers increased from pre-training to post-training. There was a statistically significant decrease in reported likelihood of all four barriers to prevent respondents from performing bystander CPR when pre-training responses were compared to post-training responses. Previous CPR training and history of having witnessed a sudden cardiac arrest (SCA) were both associated with decreased barriers to CPR, but previous training had no effect on reported likelihood of or confidence in performing CPR. The training initiative studied significantly reduced the reported likelihood of all barriers studied to prevent respondents from performing bystander CPR and also increased the reported confidence in doing CPR and

  16. Interposed Abdominal Compression CPR for an Out-of-Hospital Cardiac Arrest Victim Failing Traditional CPR

    Directory of Open Access Journals (Sweden)

    Christian D. McClung

    2015-10-01

    Full Text Available Interposed abdominal compression cardiopulmonary resuscitation (IAC-CPR is an alternative technique to traditional cardiopulmonary resuscitation (CPR that can improve perfusion and lead to restoration of circulation in patients with chest wall deformity either acquired through vigorous CPR or co-morbidity such as chronic obstructive pulmonary disease. We report a case of out-of-hospital cardiac arrest where IAC-CPR allowed for restoration of spontaneous circulation and eventual full neurologic recovery when traditional CPR was failing to generate adequate pulses with chest compression alone.

  17. CPR - child (1 to 8 years old)

    Science.gov (United States)

    Rescue breathing and chest compressions - child; Resuscitation - cardiopulmonary - child; Cardiopulmonary resuscitation - child ... All parents and those who take care of children should learn infant and child CPR if they ...

  18. CPR Instruction in a Human Anatomy Class.

    Science.gov (United States)

    Lutton, Lewis M.

    1978-01-01

    Describes how cardiopulmonary resuscitation (CPR) instruction can be included in a college anatomy and physiology course. Equipment and instructors are provided locally by the Red Cross or American Heart Association. (MA)

  19. Constitutive disease resistance requires EDS1 in the Arabidopsis mutants cpr1 and cpr6 and is partially EDS1-dependent in cpr5.

    Science.gov (United States)

    Clarke, J D; Aarts, N; Feys, B J; Dong, X; Parker, J E

    2001-05-01

    The systemic acquired resistance (SAR) response in Arabidopsis is characterized by the accumulation of salicylic acid (SA), expression of the pathogenesis-related (PR) genes, and enhanced resistance to virulent bacterial and oomycete pathogens. The cpr (constitutive expressor of PR genes) mutants express all three SAR phenotypes. In addition, cpr5 and cpr6 induce expression of PDF1.2, a defense-related gene associated with activation of the jasmonate/ethylene-mediated resistance pathways. cpr5 also forms spontaneous lesions. In contrast, the eds1 (enhanced disease susceptibility) mutation abolishes race-specific resistance conferred by a major subclass of resistance (R) gene products in response to avirulent pathogens. eds1 plants also exhibit increased susceptibility to virulent pathogens. Epistasis experiments were designed to explore the relationship between the cpr- and EDS1-mediated resistance pathways. We found that a null eds1 mutation suppresses the disease resistance phenotypes of both cpr1 and cpr6. In contrast, eds1 only partially suppresses resistance in cpr5, leading us to conclude that cpr5 expresses both EDS1-dependent and EDS1-independent components of plant disease resistance. Although eds1 does not prevent lesion formation on cpr5 leaves, it alters their appearance and reduces their spread. This phenotypic difference is associated with increased pathogen colonization of cpr5 eds1 plants compared to cpr5. The data allow us to place EDS1 as a necessary downstream component of cpr1- and cpr6-mediated responses, but suggest a more complex relationship between EDS1 and cpr5 in plant defense.

  20. Regions With Low Rates of Bystander Cardiopulmonary Resuscitation (CPR) Have Lower Rates of CPR Training in Victoria, Australia.

    Science.gov (United States)

    Bray, Janet E; Straney, Lahn; Smith, Karen; Cartledge, Susie; Case, Rosalind; Bernard, Stephen; Finn, Judith

    2017-06-05

    Bystander cardiopulmonary resuscitation (CPR) more than doubles the chance of surviving an out-of-hospital cardiac arrest. Recent data have shown considerable regional variation in bystander CPR rates across the Australian state of Victoria. This study aims to determine whether there is associated regional variation in rates of CPR training and willingness to perform CPR in these communities. We categorized each Victorian postcode as either a low or high bystander CPR region using data on adult, bystander-witnessed, out-of-hospital cardiac arrests of presumed cardiac etiology (n=7175) from the Victorian Ambulance Cardiac Arrest Registry. We then surveyed adult Victorians (n=404) and compared CPR training data of the respondents from low and high bystander CPR regions. Of the 404 adults surveyed, 223 (55%) resided in regions with low bystander CPR. Compared with respondents from high bystander CPR regions, respondents residing in regions with low bystander CPR had lower rates of CPR training (62% versus 75%, P=0.009) and lower self-ratings for their overall knowledge of CPR (76% versus 84%, P=0.04). There were no differences between the regions in their reasons for not having undergone CPR training or in their willingness to perform CPR. Rates of survival for bystander-witnessed, out-of-hospital cardiac arrests were significantly lower in low bystander CPR regions (15.7% versus 17.0%, Pbystander CPR in Victoria, Australia. Targeting these regions with CPR training programs may improve bystander CPR rates and out-of-hospital cardiac arrest outcomes. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

  1. A Novel HW/SW Based NoC Router Self-Testing Methodology

    OpenAIRE

    Nazari, Masoom; Lighvan, Mina Zolfy; Koozekonani, Ziaeddin Daie; Sadeghi, Ali

    2016-01-01

    Network-on-Chip (NoC) architecture has been proposed to solve the global communication problem of complex Systems-on-Chips (SoCs). However, NoC testing is a main challenging problem yet. In this article, we propose novel test architecture for NoC router testing. The proposed test architecture uses both advantages of Software Based Self-Testing (SBST) and Built in Self-Testing (BIST) methodologies. In this methodology, we propose custom test instructions with regarding the ISA of NoC processor...

  2. An Adaptive Property-Aware HW/SW Framework for DDDAS

    Science.gov (United States)

    2014-10-21

    HRTSC) architecture for NIOS II processor was described in Varela et al. (2012), which could be configured to run any priority-based scheduling...systems’, Software, IEEE, Vol. 8, No. 3, pp.62–72. Varela , M., Cayssials, R., Ferro, E. and Boemo, E. (2012) ‘Real-time scheduling coprocessor for

  3. HW/SW Design Space Exploration on the Production Cell Setup

    NARCIS (Netherlands)

    Groothuis, M.A.; Welch, P.H.; Roebbers, H.; Broenink, Johannes F.; Barnes, F.R.M.

    This paper describes and compares five CSP based and two CSP related process-oriented motion control system implementations that are made for our Production Cell demonstration setup. Five implementations are software-based and two are FPGA hardware-based. All implementations were originally made

  4. Chances of Successful CPR Dwindle as Seniors Age

    Science.gov (United States)

    ... gov/news/fullstory_165865.html Chances of Successful CPR Dwindle as Seniors Age Study finds fewer older ... new study finds that older Americans have little CPR training, and they are less likely to get ...

  5. CPR - child 1 to 8 years old - slideshow

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/presentations/100215.htm CPR - child 1 to 8 years old - series—Check ... and retrieve an AED until you have performed CPR for about 2 minutes. 3. Carefully place the ...

  6. Reliability measures of a computer system with priority to PM over the H/W repair activities subject to MOT and MRT

    Directory of Open Access Journals (Sweden)

    Ashish Kumar

    2015-01-01

    Full Text Available This paper concentrates on the evaluation of reliability measures of a computer system of two-identical units having independent failure of h/w and s/w components. Initially one unit is operative and the other is kept as spare in cold standby. There is a single server visiting the system immediately whenever needed. The server conducts preventive maintenance of the unit after a maximum operation time. If server is unable to repair the h/w components in maximum repair time, then components in the unit are replaced immediately by new one. However, only replacement of the s/w components has been made at their failure. The priority is given to the preventive maintenance over repair activities of the h/w. The time to failure of the components follows negative exponential distribution whereas the distribution of preventive maintenance, repair and replacement time are taken as arbitrary. The expressions for some important reliability measures of system effectiveness have been derived using semi-Markov process and regenerative point technique. The graphical behavior of the results has also been shown for a particular case.

  7. [CPR education in Japan--past, present and future].

    Science.gov (United States)

    Tanaka, Hideharu; Nakao, Ami; Mizumoto, Hanako; Kinoshi, Tomoya; Nakayama, Yuki; Takahashi, Hiroyuki; Shimazaki, Shuji

    2011-04-01

    the last 7 years, more than 300,000 automated external defibrillators(AEDs) installed nationwide in Japan, and at least one AED has placed in 38,634 schools. Therefore, only 0.7% of bystanders used the AEDs(By-AED) in all OHCA cases with th 48 % of ROSC. In recent years, elementary and junior high school student has interested in AED results in each school has at least one AED. Therefore, introduction of CPR education starting from elementary school was extremely important. CPR education is not yet ubiquitous, and the promotion of AEDs and CPR education on a nationwide scale remains an urgent issue. Therefore, to solve this problem, we investigated the status of CPR education in schools teachers. We conducted surveys targeting for school teachers in Tokyo. Question; "What age do you think suitable for CPR training ?" Most of teachers answered"Suitable age for start CPR education from the upper grades of elementary school to a junior high school". Reason is, physically, continuous high quality chest compression could performed age of junior high. However, 'Importance of life' could teach from lower grade of elementary school because of child have a good long time memory. In this reason, CPR education is extremely important. Also teachers need 'more time', 'curriculum for CPR education and 'good CPR instruction tool for teaching'. The solution to teacher's request, we prepared follows. A 90 minutes hands only CPR curriculum should be introduced to elementary school CPR for basic CPR education. CPR +AED education should be started in lower grade of elementary school with AED trainer. In conclusion, school CPR programs are extremely important for awareness both in skill and knowledge of CPR among the entire school. Future research is warranted to improve the resuscitation rate by school CPR program.

  8. Improving the hemodynamics of CPR. AHA guidelines support timely and effective CPR.

    Science.gov (United States)

    Wesley, A Keith

    2006-03-01

    More research is needed to improve our understanding of what constitutes the most effective method of cardiopulmonary resuscitation; however, we know more now than ever in the history of medicine. We know that CPR is more than simply pushing on the chest and defibrillating the heart. We know that there exists an optimal physiologic condition to facilitate successful resuscitation that relies on quality coronary and cerebral artery perfusion and preparation of the heart before defibrillation. There are many questions yet to be answered, such as how long defibrillation should be delayed following CPR, which devices or techniques provide the most effective CPR, and what are the most effective ratios of compression and ventilation? The answer may lie within a combination of approaches using multiple devices and techniques simultaneously in an attempt to meet the goals for performing the most effective CPR. What is clear is that the science of cardiac arrest is maturing, and what began in the early ages as an act of faith and desperation has now become grounded in logical reason and understanding of the physiology of cardiac arrest and the hemodynamics of CPR.

  9. Zinc finger domain of Su(Hw) protein is required for the formation of functional Su(Hw)-dependent insulator complex.

    Science.gov (United States)

    Golovnin, A K; Molodina, V V; Georgiev, P G; Melnikova, L S

    2016-07-01

    This study is devoted to clarifying the role of Mod(mdg4)-67.2 and Su(Hw) proteins in the interaction between Su(Hw)-dependent insulator complexes and identifying the specific domains of the Su(Hw) protein required for insulation or mutual neutralization of insulators. Using genetic techniques and experiments in yeast two-hybrid system, we have demonstrated that the zinc finger domain of the Su(Hw) protein is involved in forming a functional insulator complex and cannot be replaced with the DNA-binding domain of the GAL4 protein.

  10. CPR in the nursing home: fool's errand or looming dilemma?

    LENUS (Irish Health Repository)

    Lyons, D

    2011-09-01

    The indications for CPR (cardiopulmonary resuscitation) have expanded greatly since the technique was introduced and theoretically it can be attempted on all prior to death. Policy initiatives (such as the British Medical Association\\/Royal College of Nursing guidelines) have attempted to provide a clinical rationale for the withholding of inappropriate CPR. Traditionally a care home was felt to be an inappropriate environment to attempt CPR but increased use of advance directives may bring the issue to the fore in this setting.

  11. Adult First Aid/CPR/AED Ready Reference

    Science.gov (United States)

    Adult First Aid/CPR/AED READY REFERENCE CHECKING AN INJURED OR ILL ADULT APPEARS TO BE UNCONSCIOUS TIP: Use disposable gloves and other ... Person must be on firm, flat surface. Remove CPR breathing barrier when giving chest compressions. LOOK FOR ...

  12. Guidelines for CPR Training in Louisiana Schools. Bulletin No. 1638.

    Science.gov (United States)

    Louisiana State Dept. of Education, Baton Rouge.

    Completion of a course in cardiopulmonary resuscitation (CPR) is required for graduation from high school in Louisiana. This bulletin presents the guidelines for a course in CPR and was prepared with the cooperation of the American Red Cross (ARC) and the American Heart Association (AHA). At the conclusion of the course, students will be prepared…

  13. Interviews with Students Enrolled in Academic CPR Workshops, Summer 2002.

    Science.gov (United States)

    Maple, Chelley

    This study focuses on students enrolled in academic CPR workshops in the summer of 2002. The goal of the study is to examine changes in the population of students with academic problems. The CPR workshops are a requirement for students that are subject to dismissal. The study was conducted in the summer of 2003 on the telephone with a random…

  14. CPR[TM]: Adopting an Out-of-Discipline Innovation

    Science.gov (United States)

    Strong, Kay E.

    2008-01-01

    Calibrated Peer Review[TM] (CPR) is a web-based instructional tool that encourages "writing gain for students" without adding "grading pain for the instructor!" The use of CPR provides students frequent opportunities to hone both writing as well as peer review skills in a guided environment. And once an assignment is authored, instructors have…

  15. Accurate methodology for channel bow impact on CPR

    Energy Technology Data Exchange (ETDEWEB)

    Bergmann, U.C. [Westinghouse Electric Sweden AB, Vaesteraas (Sweden)

    2012-11-01

    An overview is given of existing CPR design criteria and the methods used in BWR reload analysis to evaluate the impact of channel bow on CPR margins. Potential weaknesses in today's methodologies are discussed. Westinghouse in collaboration with KKL and Axpo - operator and owner of the Leibstadt NPP - has developed an enhanced CPR methodology based on a new criterion to protect against dryout during normal operation and with a more rigorous treatment of channel bow. The new steady-state criterion is expressed in terms of an upper limit of 0.01 for the dryout failure probability per year. This is considered a meaningful and appropriate criterion that can be directly related to the probabilistic criteria set-up for the analyses of Anticipated Operation Occurrences (AOOs) and accidents. In the Monte Carlo approach a statistical modeling of channel bow and an accurate evaluation of CPR response functions allow the associated CPR penalties to be included directly in the plant SLMCPR and OLMCPR in a best-estimate manner. In this way, the treatment of channel bow is equivalent to all other uncertainties affecting CPR. The enhanced CPR methodology has been implemented in the Westinghouse Monte Carlo code, McSLAP. The methodology improves the quality of dryout safety assessments by supplying more valuable information and better control of conservatisms in establishing operational limits for CPR. The methodology is demonstrated with application examples from the introduction at KKL. (orig.)

  16. A randomized controlled trial comparing traditional training in cardiopulmonary resuscitation (CPR) to self-directed CPR learning in first year medical students: The two-person CPR study.

    Science.gov (United States)

    Roppolo, Lynn P; Heymann, Rahm; Pepe, Paul; Wagner, James; Commons, Bradford; Miller, Ronna; Allen, Emilie; Horne, Leyla; Wainscott, Michael P; Idris, Ahamed H

    2011-03-01

    The primary purpose of this study was to compare two, shorter, self-directed methods of cardiopulmonary resuscitation (CPR) education for healthcare professionals (HCP) to traditional training with a focus on the trainee's ability to perform two-person CPR. First-year medical students with either no prior CPR for HCP experience or prior training greater than 5 years were randomized to complete one of three courses: 1) HeartCode BLS System, 2) BLS Anytime, or 3) Traditional training. Only data from the adult CPR skills testing station was reviewed via video recording by certified CPR instructors and the Laerdal PC Skill Reporter software program (Laerdal Medical, Stavanger, Norway). There were 180 first-year medical students who met inclusion criteria: 68 were HeartCode BLS System, 53 BLS Anytime group, and 59 traditional group Regarding two-person CPR, 57 (84%) of Heartcode BLS students and 43 (81%) of BLS Anytime students were able to initiate the switch compared to 39 (66%) of traditional course students (p = 0.04). There were no significant differences in the quality of chest compressions or ventilations between the three groups. There was a trend for a much higher CPR skills testing pass rate for the traditional course students. However, failure to "clear to analyze or shock" while using the AED was the most common reason for failure in all groups. The self-directed learning groups not only had a high level of success in initiating the "switch" to two-person CPR, but were not significantly different from students who completed traditional training. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  17. Data of evolutionary structure change: 1CMWA-2HW3A [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1CMWA-2HW3A 1CMW 2HW3 A A PKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFA...DRERLRAFLERLEFGSLLHEFGLLESPALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARG--GRVHRAPEPY---KA... 0 1CMW A 1CMWA...ex> 1CMW A 1CMWA GLG...ex> 1CMW A 1CMWA

  18. Cardiopulmonary resuscitation (CPR)-related posterior rib fractures in neonates and infants following recommended changes in CPR techniques.

    Science.gov (United States)

    Franke, I; Pingen, A; Schiffmann, H; Vogel, M; Vlajnic, D; Ganschow, R; Born, M

    2014-07-01

    Posterior rib fractures are highly indicative of non-accidental trauma (NAT) in infants. Since 2000, the "two-thumbs" technique for cardiopulmonary resuscitation (CPR) of newborns and infants has been recommended by the American Heart Association (AHA). This technique is similar to the grip on an infant's thorax while shaking. Is it possible that posterior rib fractures in newborns and infants could be caused by the "two-thumbs" technique? Using computerized databases from three German children's hospitals, we identified all infants less than 12 months old who underwent professional CPR within a 10-year period. We included all infants with anterior-posterior chest radiographs taken after CPR. Exclusion criteria were sternotomy, osteopenia, various other bone diseases and NAT. The radiographs were independently reviewed by the Chief of Pediatric Radiology (MB) and a Senior Pediatrician, Head of the local Child Protection Team (IF). Eighty infants with 546 chest radiographs were identified, and 50 of those infants underwent CPR immediately after birth. Data concerning the length of CPR was available for 41 infants. The mean length of CPR was 11min (range: 1-180min, median: 3min). On average, there were seven radiographs per infant. A total of 39 infants had a follow-up radiograph after at least 10 days. No rib fracture was visible on any chest X-ray. The results of this study suggest rib fracture after the use of the "two-thumbs" CPR technique is uncommon. Thus, there should be careful consideration of abuse when these fractures are identified, regardless of whether CPR was performed and what technique used. The discovery of rib fractures in an infant who has undergone CPR without underlying bone disease or major trauma warrants a full child protection investigation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. PyCPR - a python-based implementation of the Conjugate Peak Refinement (CPR) algorithm for finding transition state structures.

    Science.gov (United States)

    Gisdon, Florian J; Culka, Martin; Ullmann, G Matthias

    2016-10-01

    Conjugate peak refinement (CPR) is a powerful and robust method to search transition states on a molecular potential energy surface. Nevertheless, the method was to the best of our knowledge so far only implemented in CHARMM. In this paper, we present PyCPR, a new Python-based implementation of the CPR algorithm within the pDynamo framework. We provide a detailed description of the theory underlying our implementation and discuss the different parts of the implementation. The method is applied to two different problems. First, we illustrate the method by analyzing the gauche to anti-periplanar transition of butane using a semiempirical QM method. Second, we reanalyze the mechanism of a glycyl-radical enzyme, namely of 4-hydroxyphenylacetate decarboxylase (HPD) using QM/MM calculations. In the end, we suggest a strategy how to use our implementation of the CPR algorithm. The integration of PyCPR into the framework pDynamo allows the combination of CPR with the large variety of methods implemented in pDynamo. PyCPR can be used in combination with quantum mechanical and molecular mechanical methods (and hybrid methods) implemented directly in pDynamo, but also in combination with external programs such as ORCA using pDynamo as interface. PyCPR is distributed as free, open source software and can be downloaded from http://www.bisb.uni-bayreuth.de/index.php?page=downloads . Graphical Abstract PyCPR is a search tool for finding saddle points on the potential energy landscape of a molecular system.

  20. EarthCARE/CPR design results and PFM development status

    Science.gov (United States)

    Maruyama, Kenta; Tomita, Eiichi; Nakatsuka, Hirotaka; Aida, Yoshihisa; Seki, Yoshihiro; Okada, Kazuyuki; Ishii, Yasuyuki; Tomiyama, Nobuhiro; Takahashi, Nobuhiro; Ohno, Yuichi; Horie, Hiroaki; Sato, Kenji

    2015-10-01

    Earth Clouds, Aerosols and Radiation Explorer (EarthCARE) is a Japanese-European collaborative earth observation satellite mission aimed to deepen understanding of the interaction process between clouds and aerosols and their effects on the Earth's radiation. The outcome of this mission is expected to improve the accuracy of global climate change prediction. As one of instruments for EarthCARE, the Cloud Profiling Radar (CPR) is the world's first space-borne Doppler cloud radar jointly developed by the Japan Aerospace Exploration Agency (JAXA) and the National Institute of Information and Communications Technology (NICT). In Japan, the critical design review of the CPR has been completed in 2013, and CPR proto-flight model was manufactured and integrated until summer in 2015. Finally, the proto-flight test have been just started. This paper describes the design results and current status of CPR proto-flight test.

  1. CPR: Purposeful Action. Putting New Life into 4-H.

    Science.gov (United States)

    Jones, Deborah A.; Smith, William C.

    1988-01-01

    In Ohio, 4-H professionals found that it is necessary to conduct market research to have an effective program. Cardiopulmonary resuscitation (CPR) training has been successful in strengthening the 4-H position in the marketplace. (JOW)

  2. Pediatric First Aid/CPR/AED Ready Reference

    Science.gov (United States)

    Pediatric First Aid/CPR/AED READY REFERENCE CHECKING AN INJURED OR ILL CHILD OR INFANT APPEARS TO ... 55 POUNDS NO BREATHING TIP: When available, use pediatric settings or pads when caring for children and ...

  3. Bystander CPR Helps Save Brain Function After Near-Drowning

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_165984.html Bystander CPR Helps Save Brain Function After Near-Drowning ... likely to recover with good brain function if bystanders immediately begin chest compressions rather than wait for ...

  4. Timely bystander CPR improves outcomes despite longer EMS times.

    Science.gov (United States)

    Park, Gwan Jin; Song, Kyoung Jun; Shin, Sang Do; Lee, Kyung Won; Ahn, Ki Ok; Lee, Eui Jung; Hong, Ki Jeong; Ro, Young Sun

    2017-08-01

    This study aimed to determine the impact of bystander CPR on clinical outcomes in patients with increasing response time from collapse to EMS response. A population-based observational study was conducted in patients with witnessed out-of-hospital cardiac arrest (OHCA) of presumed cardiac etiology from 2012 to 2014. The time interval from collapse to CPR by EMS providers was categorized into quartile groups: fastest group (bystander CPR and the time interval from collapse to CPR by EMS providers. A total of 15,354 OHCAs were analyzed. Bystander CPR was performed in 8591 (56.0%). Survival to hospital discharge occurred in 1632 (10.6%) and favorable neurological outcome in 996 (6.5%). In an interaction model of bystander CPR, compared to the fastest group, adjusted odds ratios (AORs) (95% CIs) for survival to discharge were 0.89 (0.66-1.20) in the fast group, 0.76 (0.57-1.02) in the late group, and 0.52 (0.37-0.73) in the latest group. For favorable neurological outcome, AORs were 1.12 (0.77-1.62) in the fast group, 0.90 (0.62-1.30) in the late group, 0.59 (0.38-0.91) in the latest group. The survival from OHCA decreases as the ambulance response time increases. The increase in mortality and worsening neurologic outcomes appear to be mitigated in those patients who receive bystander CPR. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. SW21 Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Juarez, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-02-10

    Los Alamos and Lawrence Livermore National Laboratories hosted the tenth annual Strategic Weapons in the 21st Century Conference (SW21) on 21 January 2016 to reinforce the national commitment to leadership and institutional excellence for nuclear deterrence. The event has been successful over the years in drawing together a diverse, high-level group of policy makers and experts from multiple disciplines to engage in informed dialogue on topics related to strategic weapons in national and international security.

  6. The SW Sex enigma

    CERN Document Server

    Dhillon, V S; Marsh, T R

    2012-01-01

    The SW Sex stars are a class of cataclysmic variables, originally identified because they shared a number of enigmatic properties - most notably, single-peaked emission lines instead of the double-peaked lines one would expect from their high-inclination accretion discs. We present high time-resolution spectrophotometry of the eclipsing nova-like variables SW Sex and DW UMa, two of the founding members of the SW Sex class. Both systems show single-peaked Balmer and HeII 4686A emission lines that appear to originate from a region in the disc that lies close to, but downstream of, the bright spot. The emission-line light curves are consistent with the finding from X-ray and ultraviolet observations that we predominantly see the flared disc rim and the unobscured back portion of the disc in these systems. In DW UMa, the HeII 4686A emission line originates from close to the white dwarf and exhibits flaring. Such flares have been used to argue for magnetically-channelled accretion, as in the intermediate polars, b...

  7. Mechanical CPR devices compared to manual CPR during out-of-hospital cardiac arrest and ambulance transport: a systematic review

    Directory of Open Access Journals (Sweden)

    Ong Marcus

    2012-06-01

    Full Text Available Abstract Aims The aim of this paper was to conduct a systematic review of the published literature to address the question: “In pre-hospital adult cardiac arrest (asystole, pulseless electrical activity, pulseless Ventricular Tachycardia and Ventricular Fibrillation, does the use of mechanical Cardio-Pulmonary Resuscitation (CPR devices compared to manual CPR during Out-of-Hospital Cardiac Arrest and ambulance transport, improve outcomes (e.g. Quality of CPR, Return Of Spontaneous Circulation, Survival”. Methods Databases including PubMed, Cochrane Library (including Cochrane database for systematic reviews and Cochrane Central Register of Controlled Trials, Embase, and AHA EndNote Master Library were systematically searched. Further references were gathered from cross-references from articles and reviews as well as forward search using SCOPUS and Google scholar. The inclusion criteria for this review included manikin and human studies of adult cardiac arrest and anti-arrhythmic agents, peer-review. Excluded were review articles, case series and case reports. Results Out of 88 articles identified, only 10 studies met the inclusion criteria for further review. Of these 10 articles, 1 was Level of Evidence (LOE 1, 4 LOE 2, 3 LOE 3, 0 LOE 4, 2 LOE 5. 4 studies evaluated the quality of CPR in terms of compression adequacy while the remaining six studies evaluated on clinical outcomes in terms of return of spontaneous circulation (ROSC, survival to hospital admission, survival to discharge and Cerebral Performance Categories (CPC. 7 studies were supporting the clinical question, 1 neutral and 2 opposing. Conclusion In this review, we found insufficient evidence to support or refute the use of mechanical CPR devices in settings of out-of-hospital cardiac arrest and during ambulance transport. While there is some low quality evidence suggesting that mechanical CPR can improve consistency and reduce interruptions in chest compressions, there is no

  8. SIMULATION BASED PLANNING FOR DESIGN OF WASHING MACHINE USING H/W & S/W CO DESIGN

    Directory of Open Access Journals (Sweden)

    Rajesh Kumar Garg

    2010-11-01

    Full Text Available A simulator is designed and developed or helping embedded system development team to plan their time schedule, work flow etc. and distribute human resources and their efforts over various phasesof washing machine development. The simulator helps in identifying development phases of washing machine for successful operations of overall system. The development process of washing machine has beendone in a cost effective way by planning and managing and simulating the system. The simulator gives the results in form of critical and near-critical phases while considering the rest of phases as concurrent development activities. The simulator has been a handytool for engineers in developing the system in an optimal manner. Hardware/Software Codesign approach in which both hardware and software designers’ work together to develop a system is used inthis work.

  9. Golden-Finger and Back-Door: Two HW/SW Mechanisms for Accelerating Multicore Computer Systems

    Directory of Open Access Journals (Sweden)

    Slo-Li Chu

    2012-01-01

    Full Text Available Continuously requirements of high-performance computing make the computer system adopt more processors within a system to improve the parallelism and throughput. Although multiple processing cores are implemented in a computer system, the complicated hardware communication mechanism between processors will decrease the performance of overall system. Besides, the unsuitable process scheduling mechanism of conventional operating system can not fully utilize the computation power of additional processors. Accordingly, this paper provides two mechanisms to overcome the above challenges by using hardware and software mechanisms, respectively. In software aspect, we propose a tool, called Golden-Finger, to dynamically adjust the scheduling policy of the process scheduler in Linux. This software mechanism can improve the performance of the specified process by occupying a processor solely. In hardware aspect, we design an effective hardware mechanism, called Back-Door, to communicate two independent processors which can not be operated together, such as the dual PowerPC 405 cores in the Xilinx ML310 system. The experimental results reveal that the two mechanisms can obtain significant performance enhancements.

  10. Communication and protocol compliance and their relation to the quality of cardiopulmonary resuscitation (CPR): A mixed-methods study of simulated telephone-assisted CPR.

    Science.gov (United States)

    Nord-Ljungquist, Helena; Brännström, Margareta; Bohm, Katarina

    2015-07-01

    In the event of a cardiac arrest, emergency medical dispatchers (EMDs) play a critical role by providing telephone-assisted cardiopulmonary resuscitation (T-CPR) to laypersons. The aim of our investigation was to describe compliance with the T-CPR protocol, the performance of the laypersons in a simulated T-CPR situation, and the communication between laypersons and EMDs during these actions. We conducted a retrospective observational study by analysing 20 recorded video and audio files. In a simulation, EMDs provided laypersons with instructions following T-CPR protocols. These were then analysed using a mixed method with convergent parallel design. If the EMDs complied with the T-CPR protocol, the laypersons performed the correct procedures in 71% of the actions. The single most challenging instruction of the T-CPR protocol, for both EMDs and laypersons, was airway control. Mean values for compression depth and frequency did not reach established guideline goals for CPR. Proper application of T-CPR protocols by EMDs resulted in better performance by laypersons in CPR. The most problematic task for EMDs as well for laypersons was airway management. The study results did not establish that the quality of communication between EMDs and laypersons performing CPR in a cardiac arrest situation led to statistically different outcomes, as measured by the quality and effectiveness of the CPR delivered. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Improving cardiopulmonary resuscitation with a CPR feedback device and refresher simulations (CPR CARES Study): a randomized clinical trial.

    Science.gov (United States)

    Cheng, Adam; Brown, Linda L; Duff, Jonathan P; Davidson, Jennifer; Overly, Frank; Tofil, Nancy M; Peterson, Dawn T; White, Marjorie L; Bhanji, Farhan; Bank, Ilana; Gottesman, Ronald; Adler, Mark; Zhong, John; Grant, Vincent; Grant, David J; Sudikoff, Stephanie N; Marohn, Kimberly; Charnovich, Alex; Hunt, Elizabeth A; Kessler, David O; Wong, Hubert; Robertson, Nicola; Lin, Yiqun; Doan, Quynh; Duval-Arnould, Jordan M; Nadkarni, Vinay M

    2015-02-01

    The quality of cardiopulmonary resuscitation (CPR) affects hemodynamics, survival, and neurological outcomes following pediatric cardiopulmonary arrest (CPA). Most health care professionals fail to perform CPR within established American Heart Association guidelines. To determine whether "just-in-time" (JIT) CPR training with visual feedback (VisF) before CPA or real-time VisF during CPA improves the quality of chest compressions (CCs) during simulated CPA. Prospective, randomized, 2 × 2 factorial-design trial with explicit methods (July 1, 2012, to April 15, 2014) at 10 International Network for Simulation-Based Pediatric Innovation, Research, & Education (INSPIRE) institutions running a standardized simulated CPA scenario, including 324 CPR-certified health care professionals assigned to 3-person resuscitation teams (108 teams). Each team was randomized to 1 of 4 permutations, including JIT training vs no JIT training before CPA and real-time VisF vs no real-time VisF during simulated CPA. The proportion of CCs with depth exceeding 50 mm, the proportion of CPR time with a CC rate of 100 to 120 per minute, and CC fraction (percentage CPR time) during simulated CPA. The quality of CPR was poor in the control group, with 12.7% (95% CI, 5.2%-20.1%) mean depth compliance and 27.1% (95% CI, 14.2%-40.1%) mean rate compliance. JIT training compared with no JIT training improved depth compliance by 19.9% (95% CI, 11.1%-28.7%; P 89.0%) in all groups. Combining both interventions showed the highest compliance with American Heart Association guidelines but was not significantly better than either intervention in isolation. The quality of CPR provided by health care professionals is poor. Using novel and practical technology, JIT training before CPA or real-time VisF during CPA, alone or in combination, improves compliance with American Heart Association guidelines for CPR that are associated with better outcomes. clinicaltrials.gov Identifier: NCT02075450.

  12. Clinical Implication of Cough CPR in Cardiac Cath Lab

    Directory of Open Access Journals (Sweden)

    Monish S Rau

    2013-02-01

    Full Text Available A 60 year-old-male with inferoposterior ST-elevation myocardial infarction (STEMI was shifted to cardiac cath lab for primary percutaneous coronary intervention (PCI. Coronary angiography revealed right coronary artery (RCA dominance with complete occlusion of the RCA in mid vessel. During angioplasty, the patient developed reperfusion induced Bezold Jarisch Reflex (BJR with profound bradycardia along with decrease in systolic pressure. The patient was asked to cough. The use of cough-CPR maintained the consciousness as the patient was getting syncopal. This report focuses on BJR and cough-CPR specific to interventional cardiology practice within the catheterization laboratory. Awareness of the fact that BJR may develop due to successful restoration of flow which can be managed with cough CPR, atropine and fluids can avoid the administration of vasoconstrictors.

  13. 77 FR 74278 - Proposed Information Collection (Internet Student CPR Web Registration Application); Comment Request

    Science.gov (United States)

    2012-12-13

    ... AFFAIRS Proposed Information Collection (Internet Student CPR Web Registration Application); Comment... solicits comments on information needed to establish an online web registration application. DATES: Written... use of other forms of information technology. Title: Internet Student CPR Web Registration Application...

  14. More U.S. Airports Offer Hands-Only CPR Training

    Science.gov (United States)

    ... 167407.html More U.S. Airports Offer Hands-Only CPR Training Kiosks that provide 5-minute sessions are ... TUESDAY, July 25, 2017 (HealthDay News) -- Hands-only CPR training is now available at kiosks in three ...

  15. The Old English "Hw(ae)t" and the Old Chinese "Hua,话"——A Look into the Etymology%Hw(ae)t本义

    Institute of Scientific and Technical Information of China (English)

    杜彪

    2007-01-01

    Hw(ae)t为古英语史诗Beowulf的开篇语,此词在现代英语中没有准确的对应词.笔者认为:(1):Hw(ae)t代表着一个很古老的词根,本意为"话";它在印欧语系语言中派生出诸多的疑问代词,英语中几乎所有疑问代词都与之有关;(2)上古汉语中若干个与"说话"有关的词及疑问助词亦与此词根有关;(3)Hw(ae)t代表一种古老的口头文学的开篇形式.Beowulf与中国人口头文学(说书)的开篇形式完全一样,因此,为Hw(ae)t的本义为"话说".

  16. Effectiveness of Interactive Video to Teach CPR Theory and Skills.

    Science.gov (United States)

    Lyness, Ann L.

    This study investigated whether an interactive video system of instruction taught cardiopulmonary resuscitation (CPR) as effectively as traditional instruction. Using standards of the American Heart Association, the study was designed with two randomized groups to be taught either by live instruction or by interactive video. Subjects were 100…

  17. The use of CPR data in fisheries research

    NARCIS (Netherlands)

    Corten, A.A.H.M.; Lindley, J.A.

    2003-01-01

    The Continuous Plankton Recorder (CPR) survey was initiated partly to contribute to our understanding of the variability of fish stocks and as a potential method for predicting fish distributions from the abundance and composition of the plankton. The latter objective has been superseded by

  18. [Lay-rescuer cardiopulmonary resuscitation (CPR)--controversies in emergency medicine: lay-rescuer CPR with or without mouth-to-mouth ventilation].

    Science.gov (United States)

    Wolcke, Benno

    2013-09-01

    An analysis of literature results reveals differences concerning the need for rescue breathing in lay-rescuer cardiopulmonary-resuscitation (CPR). Observational studies on large registries have shown improved survival rates with standard CPR (chest compressions and rescue breathing) compared to continuous chest compressions (CCC). This applies especially for cardiac arrests of non-cardiac origin or prolonged EMS-arrival times. In contrast a public program for lay-rescuers focusing on CCC lead to improved success rates of bystander-CPR, followed by improved survival rates. The 2010 ERC guidelines have resolved this controversy by integrating both aspects. CCC is recommended for everyone. Trained bystanders should use standard-CPR as method of choice. For dispatcher-assisted CPR the results are clear. Giving instructions for mouth-to-mouth ventilation is too complicated and time consuming, thus impairing survival rates. Therefore CCC is recommended for dispatcher-assisted CPR. © Georg Thieme Verlag Stuttgart · New York.

  19. Performance of different support surfaces during experimental resuscitation (CPR

    Directory of Open Access Journals (Sweden)

    Esa Soppi

    2016-02-01

    Full Text Available The relationship between the efficacy of resuscitation and the mattresses and backboards used in acute care units, has been studied previously. However, few reports focus on the relative efficacy of resuscitation when using mattresses with different modes of function. This study examines the performance of different support surfaces during experimental cardiopulmonary resuscitation (CPR. The surfaces included a hard surface, a higher specification foam mattress, a dynamic, alternating pressure mattress, and a dynamic, reactive minimum pressure air mattress system. A pressure sensitive mat was placed between the mattresses and each surface and the efficacy of resuscitation measured using differences in compression frequency, compression depth and hands-on time. Our results suggest that the efficacy of resuscitation is dependent on the mode of action of the mattress, while adequate compression frequency and depth do not have a significant effect. In the open system alternating mattress, deflation of the mattress using the CPR function improved the stability of the resuscitation in our study, especially in situations where the height of the air mattress is greater than 20–25 centimeters. Using our experimental system, resuscitation on a closed air system mattress optimally combined stability and effort, while the CPR function converts the air system of the mattress to open, which impairs its functionality during resuscitation. These results indicate that resuscitation is dependent of the mode of action of the mattress and whether the mattress-specific CPR function was used or not. However, the interactions are complex and are dependent on the interaction between the body and the mattress, i.e. its immersion and envelopment properties. Furthermore, this study casts doubt on the necessity of the CPR function in air mattresses.

  20. Dissemination of CPR video self-instruction materials to secondary trainees: Results from a hospital-based CPR education trial.

    Science.gov (United States)

    Ikeda, Daniel J; Buckler, David G; Li, Jiaqi; Agarwal, Amit K; Di Taranti, Laura J; Kurtz, James; Reis, Ryan Dos; Leary, Marion; Abella, Benjamin S; Blewer, Audrey L

    2016-03-01

    Cardiopulmonary resuscitation (CPR) video self-instruction (VSI) materials have been promoted as a scalable approach to increase the prevalence of CPR skills among the lay public, in part due to the opportunity for secondary training (i.e., sharing of training materials). However, the motivations for, and barriers to, disseminating VSI materials to secondary trainees is poorly understood. This work represents an ancillary investigation of a prospective hospital-based CPR education trial in which family members of cardiac patients were trained using VSI. Mixed-methods surveys were administered to primary trainees six months after initial enrollment. Surveys were designed to capture motivations for, and barriers to, sharing VSI materials, the number of secondary trainees with whom materials were shared, and the settings, timing, and recipients of trainings. Between 07/2012 and 05/2015, 653 study participants completed a six-month follow-up interview. Of those, 345 reported sharing VSI materials with 1455 secondary trainees. Materials were shared most commonly with family members. In a logistic regression analysis, participants in the oldest quartile (age >63 years) were less likely to share materials compared to those in the youngest quartile (age ≤ 44 years, OR 0.58, CI 0.37-0.90, p=0.02). Among the 308 participants who did not share their materials, time constraints was the most commonly cited barrier for not sharing. VSI materials represent a strategy for secondary dissemination of CPR training, yet older individuals have a lower likelihood of sharing relative to younger individuals. Further work is warranted to remedy perceived barriers to CPR dissemination among the lay public using VSI approaches. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  1. Dissemination of CPR video self-instruction materials to secondary trainees: results from a hospital-based CPR education trial

    Science.gov (United States)

    Ikeda, Daniel J.; Buckler, David G.; Li, Jiaqi; Agarwal, Amit K.; Di Taranti, Laura J.; Kurtz, James; dos Reis, Ryan; Leary, Marion; Abella, Benjamin S.; Blewer, Audrey L.

    2016-01-01

    Background Cardiopulmonary resuscitation (CPR) video self-instruction (VSI) materials have been promoted as a scalable approach to increase the prevalence of CPR skills among the lay public, in part due to the opportunity for secondary training (i.e., sharing of training materials). However, the motivations for, and barriers to, disseminating VSI materials to secondary trainees is poorly understood. Methods This work represents an ancillary investigation of a prospective hospital-based CPR education trial in which family members of cardiac patients were trained using VSI. Mixed-methods surveys were administered to primary trainees six months after initial enrollment. Surveys were designed to capture motivations for, and barriers to, sharing VSI materials, the number of secondary trainees with whom materials were shared, and the settings, timing, and recipients of trainings. Results Between 07/2012–05/2015, 653 study participants completed a six-month follow-up interview. Of those, 345 reported sharing VSI materials with 1455 secondary trainees. Materials were shared most commonly with family members. In a logistic regression analysis, participants in the oldest quartile (age > 63 years) were less likely to share materials compared to those in the youngest quartile (age ≤ 44 years, OR 0.58, CI 0.37–0.90, p=0.02). Among the 308 participants who did not share their materials, time constraints was the most commonly cited barrier for not sharing. Conclusions VSI materials represent a strategy for secondary dissemination of CPR training, yet older individuals have a lower likelihood of sharing relative to younger individuals. Further work is warranted to remedy perceived barriers to CPR dissemination among the lay public using VSI approaches. PMID:26776900

  2. The study of the effectiveness of chest compressions using the CPR-plus.

    Science.gov (United States)

    Elding, C; Baskett, P; Hughes, A

    1998-03-01

    Effective cardiopulmonary resuscitation (CPR) requires a high level of skill from both healthcare professionals and the lay public. Inadequate chest compressions are a common cause of ineffective CPR. The CPR-plus is a non-invasive, hand-held, simple to use CPR adjunct designed to assist the rescuer to monitor and modify the compression technique during CPR, hopefully resulting in improved rescuer performance and more effective CPR. Forty qualified nurses were evaluated while they performed chest compressions on a training manikin. During simulated two-rescuer CPR (compression/ventilation ratio 5:1) the participants performed 150 compressions at a rate of 80-100 min. Compressions were performed with and without the CPR-plus and the results compared. The use of the CPR-plus was randomised with regard to whether the adjunct or the standard method was used first. The average number of correctly applied compressions was significantly better when the CPR-plus was used: 138.35/150 versus 110.70/150 (p = 0.0001). Improvements in techniques associated with the use of the CPR-plus also included a reduction in excessive application of pressure and incorrect hand position. The device provided reassurance of satisfactory compressions and an indication of impending fatigue in the rescuer.

  3. Marginally effective medical care: ethical analysis of issues in cardiopulmonary resuscitation (CPR)

    Science.gov (United States)

    Hilberman, M; Kutner, J; Parsons, D; Murphy, D J

    1997-12-01

    Outcomes from cardiopulmonary resuscitation (CPR) remain distressingly poor. Overuse of CPR is attributable to unrealistic expectations, unintended consequences of existing policies and failure to honour patient refusal of CPR. We analyzed the CPR outcomes literature using the bioethical principles of beneficence, non-maleficence, autonomy and justice and developed a proposal for selective use of CPR. Beneficence supports use of CPR when most effective. Non-maleficence argues against performing CPR when the outcomes are harmful or usage inappropriate. Additionally, policies which usurp good clinical judgment and moral responsibility, thereby contributing to inappropriate CPR usage, should be considered maleficent. Autonomy restricts CPR use when refused but cannot create a right to CPR. Justice requires that we define which medical interventions contribute sufficiently to health and happiness that they should be made universally available. This ordering is necessary whether one believes in the utilitarian standard or wishes medical care to be universally available on fairness grounds. Low-yield CPR fails justice criteria. Cardiopulmonary resuscitation should be performed when justified by the extensive outcomes literature; not performed when not desired by the patient or not indicated; and performed infrequently when relatively contraindicated.

  4. Improving workplace safety training using a self-directed CPR-AED learning program.

    Science.gov (United States)

    Mancini, Mary E; Cazzell, Mary; Kardong-Edgren, Suzan; Cason, Carolyn L

    2009-04-01

    Adequate training in cardiopulmonary resuscitation (CPR) and use of an automated external defibrillator (AED) is an important component of a workplace safety training program. Barriers to traditional in-classroom CPR-AED training programs include time away from work to complete training, logistics, learner discomfort over being in a classroom setting, and instructors who include information irrelevant to CPR. This study evaluated differences in CPR skills performance between employees who learned CPR using a self-directed learning (SDL) kit and employees who attended a traditional instructor-led course. The results suggest that the SDL kit yields learning outcomes comparable to those obtained with traditional instructor-led courses and is a more time-efficient tool for CPR-AED training. Furthermore, the SDL kit overcomes many of the barriers that keep individuals from learning CPR and appears to contribute to bystanders' confidently attempting resuscitation.

  5. Optimal control of CPR procedure using hemodynamic circulation model

    Science.gov (United States)

    Lenhart, Suzanne M.; Protopopescu, Vladimir A.; Jung, Eunok

    2007-12-25

    A method for determining a chest pressure profile for cardiopulmonary resuscitation (CPR) includes the steps of representing a hemodynamic circulation model based on a plurality of difference equations for a patient, applying an optimal control (OC) algorithm to the circulation model, and determining a chest pressure profile. The chest pressure profile defines a timing pattern of externally applied pressure to a chest of the patient to maximize blood flow through the patient. A CPR device includes a chest compressor, a controller communicably connected to the chest compressor, and a computer communicably connected to the controller. The computer determines the chest pressure profile by applying an OC algorithm to a hemodynamic circulation model based on the plurality of difference equations.

  6. Optimal control applied to a thoraco-abdominal CPR model.

    Science.gov (United States)

    Jung, Eunok; Lenhart, Suzanne; Protopopescu, Vladimir; Babbs, Charles

    2008-06-01

    The techniques of optimal control are applied to a validated blood circulation model of cardiopulmonary resuscitation (CPR), consisting of a system of seven difference equations. In this system, the non-homogeneous forcing terms are chest and abdominal pressures acting as the 'controls'. We seek to maximize the blood flow, as measured by the pressure difference between the thoracic aorta and the right atrium. By applying optimal control methods, we characterize the optimal waveforms for external chest and abdominal compression during cardiac arrest and CPR in terms of the solutions of the circulation model and of the corresponding adjoint system. Numerical results are given for various scenarios. The optimal waveforms confirm the previously discovered positive effects of active decompression and interposed abdominal compression. These waveforms can be implemented with manual (Lifestick-like) and mechanical (vest-like) devices to achieve levels of blood flow substantially higher than those provided by standard CPR, a technique which, despite its long history, is far from optimal.

  7. Performing CPR on a commercial diver inside the diving bell

    Directory of Open Access Journals (Sweden)

    Sourabh Bhutani

    2015-01-01

    Full Text Available CPR in a diving bell is difficult. It is taught by diving companies and training institutes but has not been subjected to the tenets of evidence based medicine. The diving bell lacks space as well as a flat hard surface to lay the patient on and therefore conventional methods of administering CPR are not possible. The diver is hung from a pulley tied to the diver's harness, and the bell flooded with water to reduce pooling of blood. Airway is established using a cervical collar to hyperextend the neck and inserting an appropriate oropharyngeal airway. Cardiac compressions are administered by the bellman using his head or the knee while holding the patient with his arms from behind. The bell can be recovered to surface only when spontaneous breathing and circulation have started. Diving bell offers a unique environment for management of unconscious casualties. Even though the method is at variance with the conventional method of administering CPR, it is the only method possible inside the bell. It is important that the method be scrutinized and refined so as to be more effective and efficacious inside the bell.

  8. A hemodynamic-directed approach to pediatric cardiopulmonary resuscitation (HD-CPR) improves survival.

    Science.gov (United States)

    Morgan, Ryan W; Kilbaugh, Todd J; Shoap, Wesley; Bratinov, George; Lin, Yuxi; Hsieh, Ting-Chang; Nadkarni, Vinay M; Berg, Robert A; Sutton, Robert M

    2017-02-01

    Most pediatric in-hospital cardiac arrests (IHCAs) occur in ICUs where invasive hemodynamic monitoring is frequently available. Titrating cardiopulmonary resuscitation (CPR) to the hemodynamic response of the individual improves survival in preclinical models of adult cardiac arrest. The objective of this study was to determine if titrating CPR to systolic blood pressure (SBP) and coronary perfusion pressure (CoPP) in a pediatric porcine model of asphyxia-associated ventricular fibrillation (VF) IHCA would improve survival as compared to traditional CPR. After 7min of asphyxia followed by VF, 4-week-old piglets received either hemodynamic-directed CPR (HD-CPR; compression depth titrated to SBP of 90mmHg and vasopressor administration to maintain CoPP ≥20mmHg); or Standard Care (compression depth 1/3 of the anterior-posterior chest diameter and epinephrine every 4min). All animals received CPR for 10min prior to the first defibrillation attempt. CPR was continued for a maximum of 20min. Protocolized intensive care was provided to all surviving animals for 4h. The primary outcome was 4-h survival. Survival rate was greater with HD-CPR (12/12) than Standard Care (6/10; p=0.03). CoPP during HD-CPR was higher compared to Standard Care (point estimate +8.1mmHg, CI95: 0.5-15.8mmHg; p=0.04). Chest compression depth was lower with HD-CPR than Standard Care (point estimate -14.0mm, CI95: -9.6 to -18.4mm; pCPR vs. Standard Care (median 5 vs. 2; pCPR improves short-term survival compared to standard depth-targeted CPR in a porcine model of pediatric asphyxia-associated VF IHCA. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  9. A hybrid approach EMD-HW for short-term forecasting of daily stock market time series data

    Science.gov (United States)

    Awajan, Ahmad Mohd; Ismail, Mohd Tahir

    2017-08-01

    Recently, forecasting time series has attracted considerable attention in the field of analyzing financial time series data, specifically within the stock market index. Moreover, stock market forecasting is a challenging area of financial time-series forecasting. In this study, a hybrid methodology between Empirical Mode Decomposition with the Holt-Winter method (EMD-HW) is used to improve forecasting performances in financial time series. The strength of this EMD-HW lies in its ability to forecast non-stationary and non-linear time series without a need to use any transformation method. Moreover, EMD-HW has a relatively high accuracy and offers a new forecasting method in time series. The daily stock market time series data of 11 countries is applied to show the forecasting performance of the proposed EMD-HW. Based on the three forecast accuracy measures, the results indicate that EMD-HW forecasting performance is superior to traditional Holt-Winter forecasting method.

  10. Special radio call signal, HW6SPS, used on the SPS Inauguration Day

    CERN Document Server

    Sagnell, Bengt

    1977-01-01

    CERN had been given a special French call sign for the occasion - HW6SPS - which was used over the weekend to contact a large number of amateur stations in Europe and world-wide to spread the happy message. The stations were manned by ~10 licensed amateur radio operators in SPS.

  11. Radar Shape Modeling Of 1996 HW1 Combined With Thermal Observations

    NARCIS (Netherlands)

    Howell, Ellen S.; Magri, C.; Nolan, M. C.; Taylor, P. A.; Vervack, R. J., Jr.; Fernandez, Y. R.; Mueller, M.; Benner, L. A. M.; Giorgini, J. D.; Scheeres, D. J.; Hicks, M. D.; Rhoades, H.; Somers, J. M.; Gaftonyuk, N. M.; Krugly, Y. N.; Kouprianov, V. V.; Molotov, I. E.; Benishek, V.; Protitch-Benishek, V.; Galad, A.; Higgins, D.; Kusnirak, P.; Pray, D.

    2010-01-01

    We observed near-Earth asteroid (8567) 1996 HW1 at the Arecibo Observatory on six dates in September 2008, obtaining radar images and spectra. By combining these data with an extensive set of new lightcurves taken during 2008-2009 and with previously published lightcurves from 2005, we were able to

  12. Context differences reveal insulator and activator functions of a Su(Hw binding region.

    Directory of Open Access Journals (Sweden)

    Alexey A Soshnev

    Full Text Available Insulators are DNA elements that divide chromosomes into independent transcriptional domains. The Drosophila genome contains hundreds of binding sites for the Suppressor of Hairy-wing [Su(Hw] insulator protein, corresponding to locations of the retroviral gypsy insulator and non-gypsy binding regions (BRs. The first non-gypsy BR identified, 1A-2, resides in cytological region 1A. Using a quantitative transgene system, we show that 1A-2 is a composite insulator containing enhancer blocking and facilitator elements. We discovered that 1A-2 separates the yellow (y gene from a previously unannotated, non-coding RNA gene, named yar for y-achaete (ac intergenic RNA. The role of 1A-2 was elucidated using homologous recombination to excise these sequences from the natural location, representing the first deletion of any Su(Hw BR in the genome. Loss of 1A-2 reduced yar RNA accumulation, without affecting mRNA levels from the neighboring y and ac genes. These data indicate that within the 1A region, 1A-2 acts an activator of yar transcription. Taken together, these studies reveal that the properties of 1A-2 are context-dependent, as this element has both insulator and enhancer activities. These findings imply that the function of non-gypsy Su(Hw BRs depends on the genomic environment, predicting that Su(Hw BRs represent a diverse collection of genomic regulatory elements.

  13. Thermophysical Modeling of Contact Binary Near-Earth Asteroid 1996 HW1

    NARCIS (Netherlands)

    Magri, C.; Howell, E. S.; Nolan, M. C.; Taylor, P. A.; Fernández, Y. R.; Mueller, M.; Rivkin, A. S.; Vervack, R. J., Jr.

    2011-01-01

    Near-Earth asteroid (8567) 1996 HW1 was observed spectroscopically at 1.9-4.0 microns during August- October 2008 using the SpeX instrument at NASA's Infrared Telescope Facility (IRTF). These spectra are being modeled using a new thermophysical program that accounts for the object's spin orientation

  14. Thermophysical Modeling of Contact Binary Near-Earth Asteroid 1996 HW1

    NARCIS (Netherlands)

    Magri, C.; Howell, E. S.; Nolan, M. C.; Taylor, P. A.; Fernández, Y. R.; Mueller, M.; Rivkin, A. S.; Vervack, R. J., Jr.

    2011-01-01

    Near-Earth asteroid (8567) 1996 HW1 was observed spectroscopically at 1.9-4.0 microns during August- October 2008 using the SpeX instrument at NASA's Infrared Telescope Facility (IRTF). These spectra are being modeled using a new thermophysical program that accounts for the object's spin orientation

  15. Beneficial effect of epinephrine infusion on cerebral and myocardial blood flows during CPR.

    Science.gov (United States)

    Koehler, R C; Michael, J R; Guerci, A D; Chandra, N; Schleien, C L; Dean, J M; Rogers, M C; Weisfeldt, M L; Traystman, R J

    1985-08-01

    It is hypothesized that epinephrine improves the ability to resuscitate the heart through a mechanism thought to be related to the increase in aortic pressure. Our results with epinephrine infusion during CPR are consistent with this hypothesis. Epinephrine selectively increased vascular resistance in noncerebral, noncoronary vascular beds, as indicated by a decrease in microsphere-determined blood flow in these areas. This increased vascular resistance raised aortic pressure during the chest compression phase and the relaxation phase of CPR. Because intracranial and right atrial pressures were only slightly higher with epinephrine, cerebral and myocardial perfusion pressures and blood flows were significantly improved. This beneficial effect (compared to no administration of a vasopressor) was more pronounced as CPR progressed beyond ten minutes. Enhanced cerebral and myocardial perfusion occurred with epinephrine when either the conventional or simultaneous compression and ventilation (SCV) mode of CPR was employed in dogs. Similar selective perfusion was sustained for 50 minutes of SCV-CPR with epinephrine, even when the onset of CPR was delayed five minutes. Regional brain blood flow differed in the delayed-CPR group in that cerebellum, brain stem, and thalamic regions initially had higher blood flows. In an infant animal model of CPR using conventional CPR in piglets, epinephrine also was found to increase cerebral and myocardial blood flows. These results show that administration of epinephrine benefits different age groups of different species with different modes of CPR; that benefits occur even with delayed onset of CPR which is associated with additional anoxia and acidosis; and that epinephrine administration is particularly effective in sustaining cerebral and coronary perfusion during prolonged CPR.

  16. The crystal structure of the Hsp90 co-chaperone Cpr7 from Saccharomyces cerevisiae.

    Science.gov (United States)

    Qiu, Yu; Ge, Qiangqiang; Wang, Mingxing; Lv, Hui; Ebrahimi, Mohammad; Niu, Liwen; Teng, Maikun; Li, Xu

    2017-02-09

    The versatility of Hsp90 can be attributed to the variety of co-chaperone proteins that modulate the role of Hsp90 in many cellular processes. As a co-chaperone of Hsp90, Cpr7 is essential for accelerating the cell growth in an Hsp90-containing trimeric complex. Here, we report the crystal structure of Cpr7 at a resolution of 1.8Å. It consists of an N-terminal PPI domain and a C-terminal TPR domain, and exhibits a U-shape conformation. Our studies revealed the aggregation state of Cpr7 in solution and the interaction properties between Cpr7 and the MEEVD sequence from the C-terminus of Hsp90. In addition, the structure and sequence analysis between Cpr7 and homologues revealed the structure basis both for the function differences between Cpr6 and Cpr7 and the functional complements between Cns1 and Cpr7. Our studies facilitate the understanding of Cpr7 and provide decent insights into the molecular mechanisms of the Hsp90 co-chaperone pathway.

  17. Viewing a brief chest-compression-only CPR video improves bystander CPR performance and responsiveness in high school students: A cluster randomized trial.

    Science.gov (United States)

    Beskind, Daniel L; Stolz, Uwe; Thiede, Rebecca; Hoyer, Riley; Burns, Whitney; Brown, Jeffrey; Ludgate, Melissa; Tiutan, Timothy; Shane, Romy; McMorrow, Deven; Pleasants, Michael; Panchal, Ashish R

    2016-07-01

    CPR training in schools is a public health initiative to improve out of hospital cardiac arrest (OHCA) survival. It is unclear whether brief video training in students improves CPR quality and responsiveness and skills retention. Determine if a brief video is as effective as classroom instruction for chest compression-only (CCO) CPR training in high school students. This was a prospective cluster-randomized controlled trial with three study arms: control (sham video), brief video (BV), and CCO-CPR class. Students were randomized and clustered based on their classrooms and evaluated using a standardized OHCA scenario measuring CPR quality (compression rate, depth, hands-off time) and responsiveness (calling 911, time to calling 911, starting compressions within 2min). Data was collected at baseline, post-intervention and 2 months. Generalized linear mixed models were used to analyze outcome data, accounting for repeated measures for each individual and clustering by class. 179 students (14-18 years) were consented in 7 classrooms (clusters). At post-intervention and 2 months, BV and CCO class students called 911 more frequently and sooner, started chest compressions earlier, and had improved chest compression rates and hands-off time compared to baseline. Chest compression depth improved significantly from baseline in the CCO class, but not in the BV group post-intervention and at 2 months. Brief CPR video training resulted in improved CPR quality and responsiveness in high school students. Compression depth only improved with traditional class training. This suggests brief educational interventions are beneficial to improve CPR responsiveness but psychomotor training is important for CPR quality. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  18. Barriers and Facilitators to Learning and Performing Cardiopulmonary Resuscitation (CPR) in Neighborhoods with Low Bystander CPR Prevalence and High Rates of Cardiac Arrest in Columbus, Ohio

    Science.gov (United States)

    Sasson, Comilla; Haukoos, Jason S.; Bond, Cindy; Rabe, Marilyn; Colbert, Susan H.; King, Renee; Sayre, Michael; Heisler, Michele

    2013-01-01

    Background Residents who live in neighborhoods that are primarily African-American, Latino, or poor are more likely to have an out-of-hospital cardiac arrest (OHCA), less likely to receive cardiopulmonary resuscitation (CPR), and less likely to survive. No prior studies have been conducted to understand the contributing factors that may decrease the likelihood of residents learning and performing CPR in these neighborhoods. The goal of this study was to identify barriers and facilitators to learning and performing CPR in three low-income, “high-risk” predominantly African American, neighborhoods in Columbus, Ohio. Methods and Results Community-Based Participatory Research (CBPR) approaches were used to develop and conduct six focus groups in conjunction with community partners in three target high-risk neighborhoods in Columbus, Ohio in January-February 2011. Snowball and purposeful sampling, done by community liaisons, was used to recruit participants. Three reviewers analyzed the data in an iterative process to identify recurrent and unifying themes. Three major barriers to learning CPR were identified and included financial, informational, and motivational factors. Four major barriers were identified for performing CPR and included fear of legal consequences, emotional issues, knowledge, and situational concerns. Participants suggested that family/self-preservation, emotional, and economic factors may serve as potential facilitators in increasing the provision of bystander CPR. Conclusion The financial cost of CPR training, lack of information, and the fear of risking one's own life must be addressed when designing a community-based CPR educational program. Using data from the community can facilitate improved design and implementation of CPR programs. PMID:24021699

  19. [CPR--guidelines 2000. New international guidelines for cardiopulmonary resuscitation].

    Science.gov (United States)

    Gervais, H W

    2001-03-01

    The "Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. An International Consensus an Science" are the first true international CPR guidelines in the history of resuscitation medicine. Experts from major international resuscitation organizations (International Liaison Committee on Resuscitation, ILCOR) achieved a consensus of recommendations which had to pass a rigorous review procedure applying the tools of evidence-based medicine: all proposed guidelines or guideline changes had to be based on critically appraised pieces of evidence which had to be integrated into a final class of recommendations. The most important changes compared to previous recommendations from either the European Resuscitation Council or the American Heart Association are presented and commented upon.

  20. Understanding and improving low bystander CPR rates: a systematic review of the literature.

    Science.gov (United States)

    Vaillancourt, Christian; Stiell, Ian G; Wells, George A

    2008-01-01

    Cardiopulmonary resuscitation (CPR) is a crucial yet weak link in the chain of survival for out-of-hospital cardiac arrest. We sought to understand the determinants of bystander CPR and the factors associated with successful training. For this systematic review, we searched 11 electronic databases, 1 trial registry and 9 scientific websites. We performed hand searches and contacted 6 content experts. We reviewed without restriction all communications pertaining to who should learn CPR, what should be taught, when to repeat training, where to give CPR instructions and why people lack the motivation to learn and perform CPR. We used standardized forms to review papers for inclusion, quality and data extraction. We grouped publications by category and classified recommendations using a standardized classification system that was based on level of evidence. We reviewed 2409 articles and selected 411 for complete evaluation. We included 252 of the 411 papers in this systematic review. Differences in their study design precluded a meta-analysis. We classified 22 recommendations; those with the highest scores were 1) 9-1-1 dispatch- assisted CPR instructions, 2) teaching CPR to family members of cardiac patients, 3) Braslow's self-training video, 4) maximizing time spent using manikins and 5) teaching the concepts of ambiguity and diffusion of responsibility. Recommendations not supported by evidence include mass training events, pulse taking prior to CPR by laymen and CPR using chest compressions alone. We evaluated and classified the potential impact of interventions that have been proposed to improve bystander CPR rates. Our results may help communities design interventions to improve their bystander CPR rates.

  1. Bioinformatics analysis for structure and function ofCPR ofPlasmodium falciparum

    Institute of Scientific and Technical Information of China (English)

    ZhigangFan; Lingmin Zhang; GuogangYan; QiangWu; XiufengGan; Saifeng Zhong; GuifenLin

    2011-01-01

    Objective:To analyse the structure and function ofNADPH-cytochrome p450 reductase(CYPOR orCPR) fromPlasmodium falciparum (Pf), and to predict its’ drug target and vaccine target. Methods: The structure, function, drug target and vaccine target ofCPR fromPlasmodium falciparum were analyzed and predicted by bioinformatics methods.Results:PfCPR, which was olderCPR, had close relationship with theCPR from otherPlasmodium species, but it was distant from its hosts, such asHomo sapiens andAnopheles.PfCPR was located in the cellular nucleus ofPlasmodium falciparum.335aa-352aa and591aa -608aa were inserted the interior side of the nuclear membrane, while151aa-265aa was located in the nucleolus organizer regions.PfCPR had40 function sites and44 protein-protein binding sites in amino acid sequence. The teriary structure of 1aa-700aa was forcep-shaped with wings.15 segments ofPfCPR had no homology withHomo sapien CPR and most were exposed on the surface of the protein. These segments had25 protein-protein binding sites. While13other segments all possessed function sites. Conclusions: The evolution or genesis ofPlasmodium falciparum is earlier than those ofHomo sapiens. PfCPR is a possible resistance site of antimalarial drug and may involve immune evasion, which is associated with parasite of sporozoite in hepatocytes.PfCPR is unsuitable as vaccine target, but it has at least 13 ideal drug targets.

  2. l978hw.m77t - MGD77 data file for Geophysical data from field activity L-9-78-HW in Hawaii from 10/12/1978 to 10/19/1978

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry, magnetics, and gravity data along with transit satellite navigation data was collected as part of field activity L-9-78-HW in Hawaii from...

  3. l978hw.m77t - MGD77 data file for Geophysical data from field activity L-9-78-HW in Hawaii from 10/12/1978 to 10/19/1978

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry, magnetics, and gravity data along with transit satellite navigation data was collected as part of field activity L-9-78-HW in Hawaii from...

  4. Application of Calibrated Peer Review (CPR) Writing Assignments to Enhance Experiments with an Environmental Chemistry Focus

    Science.gov (United States)

    Margerum, Lawrence D.; Gulsrud, Maren; Manlapez, Ronald; Rebong, Rachelle; Love, Austin

    2007-01-01

    The browser-based software program, Calibrated Peer Review (CPR) developed by the Molecular Science Project enables instructors to create structured writing assignments in which students learn by writing and reading for content. Though the CPR project covers only one experiment in general chemistry, it might provide lab instructors with a method…

  5. Manual and automated cardiopulmonary resuscitation (CPR): a comparison of associated injury patterns.

    Science.gov (United States)

    Pinto, Deborrah C; Haden-Pinneri, Kathryn; Love, Jennifer C

    2013-07-01

    The purpose of this study was to identify and compare patterns of trauma associated with AutoPulse(®) CPR and manual CPR. Finalized autopsy records from 175 decedents brought to the Harris County Institute of Forensic Sciences were reviewed, 87 received manual-only CPR, and 88 received AutoPulse(®) CPR (in combination with manual CPR as per standard protocol). The characteristic pattern observed in manual-only CPR use included a high frequency of anterior rib fractures, sternal fractures, and midline chest abrasions along the sternum. The characteristic pattern observed in AutoPulse(®) CPR use included a high frequency of posterior rib fractures, skin abrasions located along the anterolateral chest and shoulder, vertebral fractures, and a few cases of visceral injuries including liver lacerations, splenic lacerations, and hemoperitoneum. Knowledge of the AutoPulse(®) CPR injury pattern can help forensic pathologists differentiate therapeutic from inflicted injuries and therefore avoid an erroneous assessment of cause and manner of death. © 2013 American Academy of Forensic Sciences.

  6. An Analysis of Calibrated Peer Review (CPR) in a Science Lecture Classroom

    Science.gov (United States)

    Walvoord, Mark E.; Hoefnagels, Marielle H.; Gaffin, Douglas D.; Chumchal, Matthew M.; Long, David A.

    2008-01-01

    Calibrated Peer Review (CPR) is an online tool being used to integrate a writing component in classrooms. In an introductory zoology lecture class, the authors found that CPR-assigned scores were significantly higher than instructor-assigned scores on two of three essay assignments. They also found that neither students' technical-writing skills…

  7. Mouth-to-mouth ventilation reduces interruptions in chest compressions during lifeguard CPR: A randomized manikin study,

    DEFF Research Database (Denmark)

    Løfgren, Bo; Adelborg, Kasper; Dalgas, Christian

    Mouth-to-mouth ventilation reduces interruptions in chest compressions during lifeguard CPR: A randomized manikin study.......Mouth-to-mouth ventilation reduces interruptions in chest compressions during lifeguard CPR: A randomized manikin study....

  8. Quantitative XRD HW-IR plot for clay mineral domain size and lattice strain analyses

    Science.gov (United States)

    Wang, H. J.; Chen, D. Z.; Zhou, J.; Chen, T.; Wang, H.; Zhang, Z. Q.

    2003-04-01

    Based on integral-breadth method, the one of three basic XRD methods (Klug &Alexander, 1974), authors (2000) proposed a qualitative half width (HW)-intensity ratio (IR) plot for clay mineral domain size and lattice strain analyses. In this study, the quantitative HW-IR plot is further developed on the basis of i) the curve relation between the Voigt function and the Pearson VII function; ii) the relationship between the Kübler index and the Weaver index. By numerical simulating, it is derived a curve relation between shape indexes k of the Voigt function and u of the Pearson VII function. With this curve relation, k and u can be converted each other in an accuracy of ten thousandth and therefore the domain size and the lattice strain contributions can be precisely separated from an XRD peak according to Langford's (1978) formula. For micaceous minerals, the HW-IR plot requires only a pair of values of the Kübler index and the Weaver index from 1nm reflection. For other clay minerals, the plot needs a pair of values of the (00l) peak's half width and intensity ratio IR. IR is a ratio of peak maximum to the intensity at the position of maximum minus 0.422oΔ2Θ in CuKα radiation. This quantitative plot renders a mean dimension of clay particles perpendicular to the reflection plane (00l) and an approximate upper limit strain normal to d001. The accuracy for domain size analysis reaches one tenth of nanometre and that for the lattice strain analysis is in ten thousandth respectively. This plot method can be widely used with any digital X-ray diffractometer, whose XRD data can be converted into text format. Excel 5.0 or latter versions in both English and Chinese can well support the HW-IR plot. This study was supported by NNSFC (Grant No 40272022)

  9. The insulator protein SU(HW fine-tunes nuclear lamina interactions of the Drosophila genome.

    Directory of Open Access Journals (Sweden)

    Joke G van Bemmel

    Full Text Available Specific interactions of the genome with the nuclear lamina (NL are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression. High-resolution mapping has recently identified hundreds of large, sharply defined lamina-associated domains (LADs in the human genome, and suggested that the insulator protein CTCF may help to demarcate these domains. Here, we report the detailed structure of LADs in Drosophila cells, and investigate the putative roles of five insulator proteins in LAD organization. We found that the Drosophila genome is also organized in discrete LADs, which are about five times smaller than human LADs but contain on average a similar number of genes. Systematic comparison to new and published insulator binding maps shows that only SU(HW binds preferentially at LAD borders and at specific positions inside LADs, while GAF, CTCF, BEAF-32 and DWG are mostly absent from these regions. By knockdown and overexpression studies we demonstrate that SU(HW weakens genome - NL interactions through a local antagonistic effect, but we did not obtain evidence that it is essential for border formation. Our results provide insights into the evolution of LAD organization and identify SU(HW as a fine-tuner of genome - NL interactions.

  10. Continuing the Search for Short Period EEB's: The Analysis of HW Persei

    Science.gov (United States)

    McDermith, R. J.; Samec, R. G.; Carrigan, B. J.

    1996-05-01

    In our continuing campaign to obtain light and radial velocity curves of short period eccentric eclipsing binary (EEB) candidates, we have obtained complete UBV observations of the neglected system, HW Persei. They were taken at Lowell Observatory in January 1996. Three new epochs of minimum light have been determined. A preliminary period study, spanning some sixty years of timings (with a 24 year gap), result in the following improved linear ephemeris, 2450097.7836(70) + 0.6348285(4)d X E. A quadratic fit was also calculated. This gave a marginally significant quadratic term of 8(6)X10-11 which translates to a period increase of 5(4)X10-8 d/yr. The U, B, V light curves formed from the present precision observations show that HW Per is a near or shallow contact system. Contrary to earlier reports that HW Per has a displaced secondary eclipse, our secondary eclipse falls at phase 0.5. A complete analysis of the synthetic light curve is presented and discussed. This research was supported by funds from the National Science Foundation.

  11. Magnetic field regulated infall on the disc around the massive protostar Cepheus A HW2

    CERN Document Server

    Vlemmings, W H T; Torstensson, K J E; van Langevelde, H J

    2010-01-01

    We present polarization observations of the 6.7-GHz methanol masers around the massive protostar Cepheus A HW2 and its associated disc. The data were taken with the Multi-Element Radio Linked Interferometer Network. The maser polarization is used to determine the full three-dimensional magnetic field structure around Cepheus A HW2. The observations suggest that the masers probe the large scale magnetic field and not isolated pockets of a compressed field. We find that the magnetic field is predominantly aligned along the protostellar outflow and perpendicular to the molecular and dust disc. From the three-dimensional magnetic field orientation and measurements of the magnetic field strength along the line of sight, we are able to determine that the high density material, in which the masers occurs, is threaded by a large scale magnetic field of ~23 mG. This indicates that the protostellar environment at ~1000 AU from Cepheus A HW2 is slightly supercritical (lambda approximately 1.7) and the relation between d...

  12. A Dynamical Analysis of the Proposed Circumbinary HW Virginis Planetary System

    CERN Document Server

    Horner, J; Wittenmyer, R A; Marshall, J P; Tinney, C G

    2012-01-01

    In 2009, the discovery of two planets orbiting the evolved binary star system HW Virginis was announced, based on systematic variations in the timing of eclipses between the two stars. The planets invoked in that work were significantly more massive than Jupiter, and moved on orbits that were mutually crossing - an architecture which suggests that mutual encounters and strong gravitational interactions are almost guaranteed. In this work, we perform a highly detailed analysis of the proposed HW Vir planetary system. First, we consider the dynamical stability of the system as proposed in the discovery work. Through a mapping process involving 91,125 individual simulations, we find that the system is so unstable that the planets proposed simply cannot exist, due to mean lifetimes of less than a thousand years across the whole parameter space. We then present a detailed re-analysis of the observational data on HW Vir, deriving a new orbital solution that provides a very good fit to the observational data. Our ne...

  13. CPR evolution of kilometer-scale craters on the lunar mare

    Science.gov (United States)

    King, Isabel; Fassett, Caleb; Thomson, Bradley J.; Minton, David A.; Watters, Wesley A.

    2016-10-01

    This study analyzes the 12.6-cm radar signature of kilometer-scale craters using data from the Mini-RF instrument on the Lunar Reconnaissance Orbiter. We examine the circular polarization ratio (CPR), which is sensitive to rockiness and surface roughness at the decimeter scale, to determine if there is a relationship between CPR signature and age for craters on the lunar mare. The craters come from an existing dataset of >13,000 craters ranging 800 m to 5 km in diameter that have previously determined degradation states based on their topography. The locations of craters in the original data set were manually co-registered to Mini-RF level 2 observations from the PDS, and for each crater, radial CPR profiles were extracted. In total, there were 5,142 unique craters with Mini-RF observations; 914 craters had repeat measurements that were used to assess uncertainties in CPR profiles. To characterize the time evolution of CPR, the craters were analyzed by finding the median profiles for groups of craters sorted by age and diameter. The highest CPR values are found in the interiors of the craters, and for craters ≤2 km, the freshest craters have the highest CPR values. In the ejecta, fresh craters exhibit the highest CPR, and this decreases with time until an equilibrium is reached. As expected from theory, larger craters' profiles evolve less quickly, with only minor changes in CPR inside their rim and a slower decrease of CPR in their ejecta. In conjunction with other datasets like topography, optical maturity, and rockiness, these data are important for constraining models of regolith evolution and crater degradation on the Moon.

  14. Shrub expansion in SW Greenland

    DEFF Research Database (Denmark)

    Jørgensen, Rasmus Halfdan

    from more southerly habitats are better adapted to climatic conditions in a warmer Greenland compared with local provenances. To answer the first question historical photographs of vegetation in SW Greenland (1898–1974) were compiled. The photos were repeated in 2010 and 2011 and 64 photo pairs were...... cropped into 133 smaller units and classified by aspect, substrate stability, muskoxen grazing and human disturbance. The photo material was evaluated by 22 experts with respect to changes in shrub cover. The results revealed a general shrub cover increase in the whole dataset, but also in a subset...... of firewood collection. A delayed reaction to the ending of the little ice age cannot be excluded, but seems rather unlikely considering other studies from Greenland. Effects of global warming in SW Greenland must be studied over even longer time periods than the 120 years of the current study. To answer...

  15. Bystander-initiated CPR in an Asian metropolitan: Does the socioeconomic status matter?☆

    Science.gov (United States)

    Chiang, Wen-Chu; Ko, Patrick Chow-In; Chang, Anna Marie; Chen, Wei-Ting; Liu, Sot Shih-Hung; Huang, Yu-Sheng; Chen, Shey-Ying; Lin, Chien-Hao; Cheng, Ming-Tai; Chong, Kah-Meng; Wang, Hui-Chih; Yang, Chih-Wei; Liao, Mao-Wei; Wang, Chen-Hsiung; Chien, Yu-Chun; Lin, Chi-Hung; Liu, Yueh-Ping; Lee, Bin-Chou; Chien, Kuo-Long; Lai, Mei-Shu; Ma, Matthew Huei-Ming

    2014-01-01

    Objectives To determine the association of neighborhood socioeconomic status (SES) with bystander-initiated cardiopulmonary resuscitation (CPR) and patient outcomes of out of hospital cardiac arrests (OHCAs) in an Asian metropolitan area. Methods We performed a retrospective study in a prospectively collected cohort from the Utstein registry of adult non-traumatic OHCAs in Taipei, Taiwan. Average real estate value was assessed as the first proxy of SES. Twelve administrative districts in Taipei City were categorized into low versus high SES areas to test the association. The primary outcome was bystander-initiated CPR, and the secondary outcome was patient survival status. Factors associated with bystander-initiated CPR were adjusted for in multivariate analysis. The mean household income was assessed as the second proxy of SES to validate the association. Results From January 1, 2008 to December 30, 2009, 3573 OHCAs received prehospital resuscitation in the community. Among these, 617 (17.3%) cases received bystander CPR. The proportion of bystander CPR in low-SES vs. high-SES areas was 14.5% vs. 19.6% (p CPR in low-SES areas was 0.72 (95% confidence interval: [0.60–0.88]) after adjusting for age, gender, witnessed status, public collapse, and OHCA unrecognized by the online dispatcher. Survival to discharge rate was significantly lower in low-SES areas vs. high-SES areas (4.3% vs. 6.8%; p CPR, and demonstrated worse survival outcomes. PMID:24056397

  16. Experimental Verification of HW-Plan Treatment Planing System%HW-Plan放射治疗计划系统的实验验证

    Institute of Scientific and Technical Information of China (English)

    陈勇; 包尚联; 黄斐增; 袁克虹; 肖桂平

    2005-01-01

    本文采用辐射胶片结合指形电离室的测量方法,借鉴AAPM 51号报告的电离室测量方法和AAMP 55报告中对放射治疗计划系统验证的推荐标准,对本实验室新研发的HW-Plan放射治疗计划系统进行了实验验证,内容包括点剂量、轴向剂量分布曲线以及等剂量曲线的验证比较.实验采用方形水模和有机玻璃模体,通过CT扫描确定模体的电子密度和模拟靶点(测量位置),采用PTW电离室测量在三野交叉共面、等中心照射条件下等中心点和偏等中心点的照射剂量,采用Kodak EDR2辐射胶片测量该条件下靶区剂量场的相对分布,并与计划系统在相同照射条件下计算的剂量场进行了验证比较,实现了对HW-Plan放射治疗计划系统验证,为计划系统的市场准入和进入临床应用提供了可靠的依据.

  17. Coexpression of CPR from various origins enhances biotransformation activity of human CYPs in S. pombe.

    Science.gov (United States)

    Neunzig, Ina; Widjaja, Maria; Peters, Frank T; Maurer, Hans H; Hehn, Alain; Bourgaud, Frédéric; Bureik, Matthias

    2013-08-01

    Cytochrome P450 enzymes (CYPs or P450s) are the most important enzymes involved in the phase I metabolism of drugs (and other xenobiotics) in humans, and the corresponding drug metabolites are needed as reference substances for their structural confirmation and for pharmacological or toxicological characterization. We have previously shown that biotechnological synthesis of such metabolites is feasible by whole-cell biotransformation with human CYPs recombinantly expressed in the fission yeast Schizosaccharomyces pombe. It was the aim of this study to compare the activity of seven human microsomal CYPs (CYP2C9, CYP2D6, CYP3A4, CYP3A5, CYP3A7, CYP17, and CYP21) upon coexpression with NADPH-cytochrome P450 oxidoreductases (CPRs) from various origins, namely, human CPR (hCPR) and its homologues from fission yeast (ccr1) and the bishop's weed Ammi majus (AmCPR), respectively. For this purpose, 28 recombinant strains were needed, with five of them having been constructed previously and 23 strains being newly constructed. Bioconversion experiments showed that coexpression of a CPR does not only influence the reaction rate but, in some cases, also exerts an influence on the metabolite pattern. For CYP3A enzymes, coexpression of hCPR yielded the best results, while for another two, hCPR was equally helpful as ccr1 (both CYP17 and CYP21) or AmCPR (CYP17 only), respectively. Interestingly, CYP2D6 displayed its highest activity when coexpressed with ccr1 and CYP2C9 with AmCPR. These results corroborate the view of CPR as a well-suited bio-brick in synthetic biology for the construction of artificial enzyme complexes.

  18. Implementing Calibrated Peer Review (CPR) in a Large-lecture Science Course

    Science.gov (United States)

    Ward, A. S.; Bettis, E. A., III; Russell, J. E.; Van Horne, S.; Sipola, M.; Rocheford, M. K.; Colombo, M. R.

    2014-12-01

    Assessing writing assignments and providing students the opportunity to meaningfully revise the assignments are challenging for instructors of large enrollment science classes. We included two individual writing assignments and peer assessments as part of course assessment for a large Introduction to Environmental Science course. In order to facilitate the assessment, Calibrated Peer Review (CPR), a web-based application developed by UCLA that enables frequent writing assignments in any discipline and with any class size, was adopted. The CPR assignment process involved four steps: submitting a writing assignment, calibrating each student's review skills, reviewing peers' writing, and assessing one's own writing assignment (self-assessment). A rubric was provided to guide students through each writing assignment and the same rubric was used in calibration, review, and self-assessment scoring. Once the instructors uploaded the writing prompts, rubrics, sample writings and answer keys into the CPR system, the CPR software fully directed all student activity (writing assignment submission, calibrations, reviews, and self-assessment). Students were able to view their results within the CPR program, including their self-calibration scores, reviewing scores, peers' ratings and feedback, total earned scores, and self-assessment scores. Surveys independently administered at the conclusion of the CPR assignments indicated that sixty to seventy-five percent of the students perceived that CPR was helpful in their learning, improved their writing and evaluation skills, and that the process of reviewing other students' essays and their own essays was more helpful than the comments received from peers. These survey results are in agreement with the well-established educational research literature that shows the benefits of peer review and peer assessment to student learning. Our experience with CPR in a large enrollment science course indicates that thoughtful planning of the

  19. Study of survival rate after cardiopulmonary resuscitation (CPR) in hospitals of Kermanshah in 2013.

    Science.gov (United States)

    Goodarzi, Afshin; Jalali, Amir; Almasi, Afshin; Naderipour, Arsalan; Kalhorii, Reza Pourmirza; Khodadadi, Amineh

    2014-07-29

    After CPR, the follow-up of survival rate and caused complications are the most important practices of the medical group. This study was performed aimed at determining the follow-up results after CPR in patients of university hospitals in Kermanshah in 2014. In this prospective study, 320 samples were examined. A purposive sampling method was used, and data was collected using a researcher-made information form with content and face validity and reliability of r= 0.79. Data was analyzed with STATA9 software and statistical tests, including calculation of the success rate, relative risk (RR), chi-square and Fisher at significance level of P CPR procedure.

  20. Arabidopsis CPR5 independently regulates seed germination and postgermination arrest of development through LOX pathway and ABA signaling.

    Directory of Open Access Journals (Sweden)

    Guilan Gao

    Full Text Available The phytohormone abscisic acid (ABA and the lipoxygenases (LOXs pathway play important roles in seed germination and seedling growth and development. Here, we reported on the functional characterization of Arabidopsis CPR5 in the ABA signaling and LOX pathways. The cpr5 mutant was hypersensitive to ABA in the seed germination, cotyledon greening and root growth, whereas transgenic plants overexpressing CPR5 were insensitive. Genetic analysis demonstrated that CPR5 gene may be located downstream of the ABI1 in the ABA signaling pathway. However, the cpr5 mutant showed an ABA independent drought-resistant phenotype. It was also found that the cpr5 mutant was hypersensitive to NDGA and NDGA treatment aggravated the ABA-induced delay in the seed germination and cotyledon greening. Taken together, these results suggest that the CPR5 plays a regulatory role in the regulation of seed germination and early seedling growth through ABA and LOX pathways independently.

  1. Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest. The randomized CIRC trial

    NARCIS (Netherlands)

    Wik, L.; Olsen, J.A.; Persse, D.; Sterz, F.; Lozano Jr, M.; Brouwer, M.A.; Westfall, M.; Souders, C.M.; Malzer, R.; Grunsven, P.M. van; Travis, D.T.; Whitehead, A.; Herken, U.R.; Lerner, E.B.

    2014-01-01

    OBJECTIVE: To compare integrated automated load distributing band CPR (iA-CPR) with high-quality manual CPR (M-CPR) to determine equivalence, superiority, or inferiority in survival to hospital discharge. METHODS: Between March 5, 2009 and January 11, 2011 a randomized, unblinded, controlled group

  2. Between symbol and index. Notes on H.W. Diamond's psychiatric pictures

    Directory of Open Access Journals (Sweden)

    Silvia Di Marco

    2015-05-01

    Full Text Available This paper takes into examination the work of one of the pioneers of photographic portrait, the English psychiatrist H.W. Diamond, in the light of Sekula’s reflection on the role played by the physiognomic theory in shaping this photographic genre during the Victorian era, and resorting to Peirce’s classification of signs into indices, icons, and symbols. These conceptual tools help understanding the functioning of Diamond’s photographs as epistemic devices, while developing a wider analysis of the indexical, iconic and symbolic nature of photographic images and photographic archives.

  3. HW Vir's Companion: a M-type Dwarf, or maybe a giant rotating spherical Mirror?

    CERN Document Server

    Edelmann, Heinz

    2008-01-01

    From optical high-resolution spectra the nature of the unseen companion of HW Vir is determined without detection of any spectral features originating from the secondary itself. Using radial velocity measurements from the primary hot subdwarf B star and from weak additional absorption lines detected close to the secondary eclipse, probably caused by reflected light off the surface of the secondary, the mass and radius of the companion is determined. The values are consistent with those of a M type main sequence star.

  4. 内置GPS HPi PAQ hw6515智能手机

    Institute of Scientific and Technical Information of China (English)

    顾国林

    2006-01-01

    近日,HP发市全球首款内置GPS的智能手机:HP iPAQ hw6515。这款产品内置了GPS全球卫星导航系统,可搭配各地的地图资料和软件,用户只需输入目的地,系统就将自动选取最佳路线,进行语音自动导航。

  5. Gluon fusion and bb¯ corrections to HW+W−/HZZ production in the POWHEG-BOX

    Directory of Open Access Journals (Sweden)

    Julien Baglio

    2017-01-01

    Full Text Available The study of the Higgs boson properties is one of the most important tasks to be accomplished in the next years, at the Large Hadron Collider (LHC and at future colliders such as the Future Circular Collider in hadron–hadron mode (FCC-hh, the potential 100 TeV follow-up of the LHC machine. In this view the precise study of the Higgs couplings to weak gauge bosons is crucial and requires as much information as possible. After the recent calculation of the next-to-leading order QCD corrections to the production cross sections and differential distributions of a Standard Model Higgs boson in association with a pair of weak bosons, matched with parton shower in the POWHEG-BOX framework, we present the gluon fusion correction gg→HW+W−(HZZ to the process pp→HW+W−(HZZ. This correction can be sizeable and amounts to +3% (+10% in the HW+W− process and +5% (+18% in the HZZ process at the LHC (FCC-hh. We also present the first study of the impact of the bottom-quark initiated channels bb¯→HW+W−/HZZ and find that they induce a significant +18% correction in the HW+W− channel at the FCC-hh. We present results on total cross sections and distributions at the LHC and at the FCC-hh.

  6. Gluon fusion and b b bar corrections to HW+W-/HZZ production in the POWHEG-BOX

    Science.gov (United States)

    Baglio, Julien

    2017-01-01

    The study of the Higgs boson properties is one of the most important tasks to be accomplished in the next years, at the Large Hadron Collider (LHC) and at future colliders such as the Future Circular Collider in hadron-hadron mode (FCC-hh), the potential 100 TeV follow-up of the LHC machine. In this view the precise study of the Higgs couplings to weak gauge bosons is crucial and requires as much information as possible. After the recent calculation of the next-to-leading order QCD corrections to the production cross sections and differential distributions of a Standard Model Higgs boson in association with a pair of weak bosons, matched with parton shower in the POWHEG-BOX framework, we present the gluon fusion correction gg → HW+W- (HZZ) to the process pp → HW+W- (HZZ). This correction can be sizeable and amounts to + 3% (+ 10%) in the HW+W- process and + 5% (+ 18%) in the HZZ process at the LHC (FCC-hh). We also present the first study of the impact of the bottom-quark initiated channels b b bar → HW+W- / HZZ and find that they induce a significant + 18% correction in the HW+W- channel at the FCC-hh. We present results on total cross sections and distributions at the LHC and at the FCC-hh.

  7. Reliability of spatial and temporal patterns of C. finmarchicus inferred from the CPR survey

    Science.gov (United States)

    Hélaouët, Pierre; Beaugrand, Grégory; Reygondeau, Gabriel

    2016-01-01

    The Continuous Plankton Recorder (CPR) survey has collected plankton since 1958 in the North Atlantic Ocean and its adjacent seas. Among all species recorded by the CPR, Calanus finmarchicus has probably been the most investigated species because of its ecological importance for the temperate and subpolar regions of the North Atlantic Ocean. However, abundances of C. finmarchicus assessed from the CPR survey have been rarely compared to more traditional sampling methodologies. In this study, we examine and compare spatial (surface and vertical) and temporal (diel and seasonal) patterns in the abundance of C. finmarchicus with another sampling technique in the gulf of Maine. Our results provide evidence that the CPR survey not only gives internally consistent time series of C. finmarchicus, but also an accurate representation of both spatial (surface and vertical) and temporal (diel and seasonal) patterns.

  8. Effect of bystander CPR initiation prior to the emergency call on ROSC and 30day survival

    DEFF Research Database (Denmark)

    Viereck, Søren; Palsgaard Møller, Thea; Kjær Ersbøll, Annette

    2017-01-01

    BACKGROUND: This study aimed at evaluating if time for initiation of bystander cardiopulmonary resuscitation (CPR) - prior to the emergency call (CPRprior) versus during the emergency call following dispatcher-assisted CPR (CPRduring) - was associated with return of spontaneous circulation (ROSC...... and corresponding emergency calls were evaluated. Multivariable logistic regression analyses were applied to evaluate the association between time for initiation of bystander CPR, ROSC, and 30-day survival. Univariable logistic regression analyses were applied to identify predictors of CPRprior. RESULTS: The study...... included 548 emergency calls for OHCA patients receiving bystander CPR, 34.9% (n=191) in the CPRprior group and 65.1% (n=357) in the CPRduring group. Multivariable analyses showed no difference in ROSC (OR=0.88, 95% CI: 0.56-1.38) or 30-day survival (OR=1.14, 95% CI: 0.68-1.92) between CPRprior...

  9. Rescuer fatigue under the 2010 ERC guidelines, and its effect on cardiopulmonary resuscitation (CPR) performance.

    Science.gov (United States)

    McDonald, Catherine H; Heggie, James; Jones, Christopher M; Thorne, Christopher J; Hulme, Jonathan

    2013-08-01

    Updated life-support guidelines were published by the European Resuscitation Council (ERC) in 2010, increasing the required depth and rate of chest compression delivery. This study sought to determine the impact of these guidelines on rescuer fatigue and cardiopulmonary resuscitation (CPR) performance. 62 Health science students performed 5 min of conventional CPR in accordance with the 2010 ERC guidelines. A SkillReporter manikin was used to objectively assess temporal change in determinants of CPR quality. Participants subjectively reported their end-fatigue levels, using a visual analogue scale, and the point at which they believed fatigue was affecting CPR delivery. 49 (79%) participants reported that fatigue affected their CPR performance, at an average of 167 s. End fatigue averaged 49.5/100 (range 0-95). The proportion of chest compressions delivered correctly decreased from 52% in min 1 to 39% in min 5, approaching significance (p=0.071). A significant decline in chest compressions reaching the recommended depth occurred between the first (53%) and fifth (38%) min (p=0.012). Almost half this decline (6%) was between the first and second minutes of CPR. Neither chest compression rate, nor rescue breath volume, were affected by rescuer fatigue. Fatigue affects chest compression delivery within the second minute of CPR under the 2010 ERC guidelines, and is poorly judged by rescuers. Rescuers should, therefore, be encouraged to interchange after 2 min of CPR delivery. Team leaders should be advised to not rely on rescuers to self-report fatigue, and should, instead, monitor for its effects.

  10. Knowledge Representation and Communication: Imparting Current State Information Flow to CPR Stakeholders

    OpenAIRE

    de la Cruz, Norberto B.; Spiece, Leslie J.

    2000-01-01

    Understanding and communicating the who, what, where, when, why, and how of the clinics and services for which the computerized patient record (CPR) will be built is an integral part of the implementation process. Formal methodologies have been developed to diagram information flow -- flow charts, state-transition diagram (STDs), data flow diagrams (DFDs). For documentation of the processes at our ambulatory CPR pilot site, flowcharting was selected as the preferred method based upon its vers...

  11. CPR methodology with new steady-state criterion and more accurate statistical treatment of channel bow

    Energy Technology Data Exchange (ETDEWEB)

    Baumgartner, S. [Axpo AG, Parkstrasse 23, CH-5401 Baden (Switzerland); Bieli, R. [Kernkraftwerk Leibstadt AG, CH-5325 Leibstadt (Switzerland); Bergmann, U. C. [Westinghouse Electric Sweden AB, SE-721 63 Vaesteraas (Sweden)

    2012-07-01

    An overview is given of existing CPR design criteria and the methods used in BWR reload analysis to evaluate the impact of channel bow on CPR margins. Potential weaknesses in today's methodologies are discussed. Westinghouse in collaboration with KKL and Axpo - operator and owner of the Leibstadt NPP - has developed an optimized CPR methodology based on a new criterion to protect against dryout during normal operation and with a more rigorous treatment of channel bow. The new steady-state criterion is expressed in terms of an upper limit of 0.01 for the dryout failure probability per year. This is considered a meaningful and appropriate criterion that can be directly related to the probabilistic criteria set-up for the analyses of Anticipated Operation Occurrences (AOOs) and accidents. In the Monte Carlo approach a statistical modeling of channel bow and an accurate evaluation of CPR response functions allow the associated CPR penalties to be included directly in the plant SLMCPR and OLMCPR in a best-estimate manner. In this way, the treatment of channel bow is equivalent to all other uncertainties affecting CPR. Emphasis is put on quantifying the statistical distribution of channel bow throughout the core using measurement data. The optimized CPR methodology has been implemented in the Westinghouse Monte Carlo code, McSLAP. The methodology improves the quality of dryout safety assessments by supplying more valuable information and better control of conservatisms in establishing operational limits for CPR. The methodology is demonstrated with application examples from the introduction at KKL. (authors)

  12. Schoolchildren as BLS instructors for relatives and friends: Impact on attitude towards bystander CPR.

    Science.gov (United States)

    Stroobants, Jan; Monsieurs, Koenraad; Devriendt, Bart; Dreezen, Christa; Vets, Philippe; Mols, Pierre

    2014-12-01

    We investigated the impact of Cardio-Pulmonary Resuscitation (CPR) instruction by children on the attitude of people to perform bystander CPR. In 2012, children from primary and secondary school (age span 11–13 years) received a free individual CPR training package containing an inexpensive manikin and a training video. After a CPR training session by their class teacher, they were invited to teach their relatives and friends. After the training, the trainees of the children were invited to participate in a web survey, containing a test and questions about prior CPR training and about their attitude towards bystander CPR (BCPR) before and after the training. We measured the impact on the attitude to perform BCPR and the theoretical knowledge transfer by the children. A total of 4012 training packages were distributed to 72 schools of which 55 class teachers subscribed their students (n = 822) for the training programme for relatives and friends. After a validation procedure, 874 trainees of 290 children were included in the study. In comparison to trainees of secondary schoolchildren, trainees of primary schoolchildren scored better for the test as well as for a positive change of attitude towards future BCPR (P Instructing schoolchildren to teach their relatives and friends in Basic Life Support (BLS) led to a more positive attitude towards BCPR. The results were more positive with trainees from primary schoolchildren than with trainees from secondary schoolchildren.

  13. Successful Prolonged Mechanical CPR in a Severely Poisoned Hypothermic Patient: A Case Report

    Directory of Open Access Journals (Sweden)

    Alberto Piacentini

    2012-01-01

    Full Text Available Mechanical cardiopulmonary resuscitation (m-CPR devices are an alternative to manual CPR, but their efficacy has been subject to debate. We present a case of a patient with full-neurologic recovery after prolonged m-CPR. The patient presented with severe hypothermia (internal temperature 24°C and poisoning (sedatives/hypnotics. Hepatic perfusion and metabolism are considered keys to restore spontaneous circulation. During this period no problems related to the device or patient positioning were encountered. Delivery of high-quality CPR and prolonged resuscitation were achieved. We confirm that ventilations asynchronous with chest compressions can be a problem. Reduction in chest measurements can hamper lung ventilation. A synchronous mode of manual ventilation (30 : 2 seems to be the best solution. The patient had an initial period of manual CPR. No damage to any organ or structure was noted. This case is of further interest because our EMS helicopters can fly 24 hours a day and m-CPR devices could play an important role as a “bridge” in patients when active rewarming by cardiopulmonary bypass is indicated (CPB.

  14. Mechanical versus manual chest compression CPR under ground ambulance transport conditions.

    Science.gov (United States)

    Fox, Julia; Fiechter, René; Gerstl, Peter; Url, Alfons; Wagner, Heinz; Lüscher, Thomas F; Eriksson, Urs; Wyss, Christophe A

    2013-03-01

    Novel mechanical chest compression devices offer the possibility to transport cardiac arrest patients with ongoing CPR and might shorten significantly the time delay to post-resuscitation care. We simulated an eight-minute cardiac resuscitation situation during ambulance transport using CPR training manikins. We compared teams consisting of two experienced resuscitators with the performance of a mechanical chest compression device (LUCAS). CPR-performance by two experienced resuscitators demonstrated ambivalent results. Whereas mean compression rate was within the recommended range (103/min, 95% CI: 93-113/min), mean compression depth was closely below the actually recommended compression depth of >5 cm (49.7 mm, 95% CI: 46.1-53.3mm). Nevertheless, only a mean of two thirds (67%) of all compressions were classified as manually correct (defined as sternal compression depth >5 cm). In contrast, the LUCAS device showed a constant and reliable CPR performance (99.96% correctly applied chest compressions correctly applied within the device programmed parameters, P = 0.0162) with almost no variance between the different sequences. The LUCAS CPR device represents a reliable alternative to manual CPR in a moving ambulance vehicle during emergency evacuation. Furthermore, it needs less human resources and is safer for the EMS personnel.

  15. Even Four Minutes of Poor Quality of CPR Compromises Outcome in a Porcine Model of Prolonged Cardiac Arrest

    Science.gov (United States)

    Li, Heng; Zhang, Lei; Yang, Zhengfei; Huang, Zitong; Chen, Bihua; Li, Yongqin; Yu, Tao

    2013-01-01

    Objective. Untrained bystanders usually delivered suboptimal chest compression to victims who suffered from cardiac arrest in out-of-hospital settings. We therefore investigated the hemodynamics and resuscitation outcome of initial suboptimal quality of chest compressions compared to the optimal ones in a porcine model of cardiac arrest. Methods. Fourteen Yorkshire pigs weighted 30 ± 2 kg were randomized into good and poor cardiopulmonary resuscitation (CPR) groups. Ventricular fibrillation was electrically induced and untreated for 6 mins. In good CPR group, animals received high quality manual chest compressions according to the Guidelines (25% of animal's anterior-posterior thoracic diameter) during first two minutes of CPR compared with poor (70% of the optimal depth) compressions. After that, a 120-J biphasic shock was delivered. If the animal did not acquire return of spontaneous circulation, another 2 mins of CPR and shock followed. Four minutes later, both groups received optimal CPR until total 10 mins of CPR has been finished. Results. All seven animals in good CPR group were resuscitated compared with only two in poor CPR group (P CPR group. Conclusions. In a porcine model of prolonged cardiac arrest, even four minutes of initial poor quality of CPR compromises the hemodynamics and survival outcome. PMID:24364028

  16. The sdB+M Eclipsing System HW Virginis and its Circumbinary Planets

    CERN Document Server

    Lee, Jae Woo; Kim, Chun-Hwey; Koch, Robert H; Lee, Chung-Uk; Kim, Ho-Il; Park, Jang-Ho

    2008-01-01

    For the very short-period sdB eclipsing binary HW Vir, we present new CCD photometry made from 2000 through 2008. In order to obtain consistency of the binary parameters, our new light curves were analyzed simultaneously with previously published radial-velocity data. The secondary star parameters of $M_2$=0.14 M$_\\odot$, $R_2$=0.18 R$_\\odot$, and $T_2$=3,084 K are consistent with those of an M6-7 main sequence star. More than 250 times of minimum light, including our 41 timings and spanning more than 24 yrs, were used for a period study. From a detailed analysis of the $O$--$C$ diagram, it emerged that the orbital period of HW Vir has varied as a combination of a downward-opening parabola and two sinusoidal variations, with cycle lengths of $P_3$=15.8 yr and $P_4$=9.1 yr and semi-amplitudes of $K_3$=77 s and $K_4$=23 s, respectively. The continuous period decrease with a rate of $-8.28\\times10^{-9}$ d yr$^{-1}$ may be produced by angular momentum loss due to magnetic stellar wind braking but not by gravitati...

  17. Radar Shape Modeling Of (8567) 1996 HW1 Combined With Thermal Observations

    Science.gov (United States)

    Howell, Ellen S.; Magri, C.; Nolan, M. C.; Taylor, P. A.; Vervack, R. J., Jr.; Fernandez, Y. R.; Mueller, M.; Benner, L. A. M.; Giorgini, J. D.; Scheeres, D. J.; Hicks, M. D.; Rhoades, H.; Somers, J. M.; Gaftonyuk, N. M.; Krugly, Y. N.; Kouprianov, V. V.; Molotov, I. E.; Benishek, V.; Protitch-Benishek, V.; Galad, A.; Higgins, D.; Kusnirak, P.; Pray, D.

    2010-10-01

    We observed near-Earth asteroid (8567) 1996 HW1 at the Arecibo Observatory on six dates in September 2008, obtaining radar images and spectra. By combining these data with an extensive set of new lightcurves taken during 2008-2009 and with previously published lightcurves from 2005, we were able to reconstruct the object's shape and spin state. 1996 HW1 is an elongated, highly bifurcated object, and appears to be a contact binary. A convex shape model derived from the lightcurves alone produces a pole orientation that is consistent with the pole derived from the radar data. It is instructive to compare these two shape models. We have also obtained near-infrared spectra at the NASA IRTF using SpeX in both prism and LXD modes. The prism spectra show pyroxene and olivine bands. We obtained LXD spectra (2-4 microns) on 19 August, 1 September and 1 October 2008. Thermal modeling using the shape model and derived pole and rotation constrain the regolith properties. The radar shape model and results of the thermal modeling will be presented.

  18. HwPMI: An Extensible Performance Monitoring Infrastructure for Improving Hardware Design and Productivity on FPGAs

    Directory of Open Access Journals (Sweden)

    Andrew G. Schmidt

    2012-01-01

    Full Text Available Designing hardware cores for FPGAs can quickly become a complicated task, difficult even for experienced engineers. With the addition of more sophisticated development tools and maturing high-level language-to-gates techniques, designs can be rapidly assembled; however, when the design is evaluated on the FPGA, the performance may not be what was expected. Therefore, an engineer may need to augment the design to include performance monitors to better understand the bottlenecks in the system or to aid in the debugging of the design. Unfortunately, identifying what to monitor and adding the infrastructure to retrieve the monitored data can be a challenging and time-consuming task. Our work alleviates this effort. We present the Hardware Performance Monitoring Infrastructure (HwPMI, which includes a collection of software tools and hardware cores that can be used to profile the current design, recommend and insert performance monitors directly into the HDL or netlist, and retrieve the monitored data with minimal invasiveness to the design. Three applications are used to demonstrate and evaluate HwPMI’s capabilities. The results are highly encouraging as the infrastructure adds numerous capabilities while requiring minimal effort by the designer and low resource overhead to the existing design.

  19. CPR1000全厂断电事故瞬态特性分析%Transient Analyses of Station Blackout Accident for CPR1000

    Institute of Scientific and Technical Information of China (English)

    张亚培; 田文喜; 秋穗正; 苏光辉

    2011-01-01

    The primary loop of CPR1000 nuclear power plant was modeled using RELAP5/MOD3. 4 code, and the transient thermal hydraulic characteristics were analyzed under the condition of station blackout accident (SBO). The calculation results by RELAP5 code were compared with those of THEMIS code, and the results by RELAP5 code were consistent with those of THEMIS code. The results show that the RELAP5 model can accurately simulate the transient thermal hydraulic characteristics of CPR1000 under the condition of SBO.%用RELAP5/MOD3.4程序对CPR1000压水堆一回路系统进行整体建模,分析全厂断电事故下一回路主要参数的瞬态热工水力特性,并将RELAP5模型计算结果与THEMIS程序的计算结果进行对比,二者符合得较好.计算结果表明:该模型可较准确地模拟CPR1000在事故下的热工水力特性.

  20. Shrub expansion in SW Greenland

    DEFF Research Database (Denmark)

    Jørgensen, Rasmus Halfdan

    to increasing shrub cover. Despite this, there is only limited experimental evidence that growth of the species responds to warming. Plant populations in fragmented and isolated locations could face problems adapting to a warming climate due to limited genetic variation and restricted migration from southern...... of firewood collection. A delayed reaction to the ending of the little ice age cannot be excluded, but seems rather unlikely considering other studies from Greenland. Effects of global warming in SW Greenland must be studied over even longer time periods than the 120 years of the current study. To answer......Arctic regions have experienced higher temperatures in recent decades, and the warming trend is projected to continue in the coming years. Arctic ecosystems are considered to be particularly vulnerable to climate change. Expansion of shrubs has been observed widely in tundra areas across the Arctic...

  1. k181hw.m77t - MGD77 data file for Geophysical data from field activity K-1-81-HW in Hawaii from 01/26/1981 to 02/05/1981

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of field activity K-1-81-HW in Hawaii from 01/26/1981 to 02/05/1981,...

  2. k181hw.m77t - MGD77 data file for Geophysical data from field activity K-1-81-HW in Hawaii from 01/26/1981 to 02/05/1981

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of field activity K-1-81-HW in Hawaii from 01/26/1981 to 02/05/1981,...

  3. An efficient HW and SW design of H.264 video compression, storage and playback on FPGA devices for handheld thermal imaging systems

    Science.gov (United States)

    Gunay, Omer; Ozsarac, Ismail; Kamisli, Fatih

    2017-05-01

    Video recording is an essential property of new generation military imaging systems. Playback of the stored video on the same device is also desirable as it provides several operational benefits to end users. Two very important constraints for many military imaging systems, especially for hand-held devices and thermal weapon sights, are power consumption and size. To meet these constraints, it is essential to perform most of the processing applied to the video signal, such as preprocessing, compression, storing, decoding, playback and other system functions on a single programmable chip, such as FPGA, DSP, GPU or ASIC. In this work, H.264/AVC (Advanced Video Coding) compatible video compression, storage, decoding and playback blocks are efficiently designed and implemented on FPGA platforms using FPGA fabric and Altera NIOS II soft processor. Many subblocks that are used in video encoding are also used during video decoding in order to save FPGA resources and power. Computationally complex blocks are designed using FPGA fabric, while blocks such as SD card write/read, H.264 syntax decoding and CAVLC decoding are done using NIOS processor to benefit from software flexibility. In addition, to keep power consumption low, the system was designed to require limited external memory access. The design was tested using 640x480 25 fps thermal camera on CYCLONE V FPGA, which is the ALTERA's lowest power FPGA family, and consumes lower than 40% of CYCLONE V 5CEFA7 FPGA resources on average.

  4. 基于NSGA-II的嵌入式系统软硬件划分方法%Method of HW/SW partitioning based on NSGA-II

    Institute of Scientific and Technical Information of China (English)

    卢小张; 刘伟; 陶耀东

    2009-01-01

    软硬件划分是软硬件协同设计中的一个关键问题.针对单处理器嵌入式系统,提出将NSGA-II应用于软硬件划分中,该算法一次运行可以获得多个Pareto最优解,为各个目标函数之间权衡分析提供了有效的工具,提高了设计效率.结果表明,通过该划分方法,在满足系统性能要求下,可为复杂嵌入式系统提供多个设计目标的全局优化方案.

  5. CPR variability during ground ambulance transport of patients in cardiac arrest.

    Science.gov (United States)

    Roosa, Jason R; Vadeboncoeur, Tyler F; Dommer, Paul B; Panchal, Ashish R; Venuti, Mark; Smith, Gary; Silver, Annemarie; Mullins, Margaret; Spaite, Daniel; Bobrow, Bentley J

    2013-05-01

    High-quality CPR is associated with improved outcomes from out-of-hospital cardiac arrest (OHCA). The purpose of this investigation was to compare the quality of CPR provided at the prehospital scene, during ambulance transport, and during the early minutes in the emergency department (ED). A prospective observational review of consecutive adult patients with non-traumatic OHCA was conducted between September 2008 and February 2010. Patients with initiation of prehospital CPR were included as part of a statewide cardiac resuscitation quality improvement program. A monitor-defibrillator with accelerometer-based CPR measurement capability (E-series, ZOLL Medical) was utilized. CPR quality measures included variability in chest compression (CC) depth and rate, mean depth and rate, and the CC fraction. Variability of CC was defined as the mean of minute-to-minute standard deviation in CC depth or rate. CC fraction was defined as the percent of time that CPR was being performed when appropriate throughout resuscitation. Fifty-seven adult patients with OHCA had electronic CPR data recorded at the scene, in the ambulance, and upon arrival in the ED. Across time periods, there was increased variability in CC depth (scene: 0.20 in.; transport: 0.26 in.; ED: 0.31 in., P<0.01) and rate (scene: 18.2 CC min(-1); transport: 26.1 CC min(-1); ED: 26.3 CC min(-1), P<0.01). The mean CC depth, rate, and the CC fraction did not differ significantly between groups. There was increased CC variability from the prehospital scene to the ED though there was no difference in mean CC depth, rate, or in CC fraction. The clinical significance of CC variability remains to be determined. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  6. Improved chest recoil using an adhesive glove device for active compression-decompression CPR in a pediatric manikin model.

    Science.gov (United States)

    Udassi, Jai P; Udassi, Sharda; Lamb, Melissa A; Lamb, Kenneth E; Theriaque, Douglas W; Shuster, Jonathan J; Zaritsky, Arno L; Haque, Ikram U

    2009-10-01

    We developed an adhesive glove device (AGD) to perform ACD-CPR in pediatric manikins, hypothesizing that AGD-ACD-CPR provides better chest decompression compared to standard (S)-CPR. Split-plot design randomizing 16 subjects to test four manikin-technique models in a crossover fashion to AGD-ACD-CPR vs. S-CPR. Healthcare providers performed 5min of CPR with 30:2 compression:ventilation ratio in the four manikin models: (1) adolescent; (2) child two-hand; (3) child one-hand; and (4) infant two-thumb. Modified manikins recorded compression pressure (CP), compression depth (CD) and decompression depth (DD). The AGD consisted of a modified oven mitt with an adjustable strap; a Velcro patch was sewn to the palmer aspect. The counter Velcro patch was bonded to the anterior chest wall. For infant CPR, the thumbs of two oven mitts were stitched together with Velcro. Subjects were asked to actively pull up during decompression. Subjects' heart rate (HR), respiratory rate (RR) and recovery time (RT) for HR/RR to return to baseline were recorded. Subjects were blinded to data recordings. Data (mean+/-SEM) were analyzed using a two-tailed paired t-test. Significance was defined qualitatively as P< or =0.05. Mean decompression depth difference was significantly greater with AGD-ACD-CPR compared to S-CPR; 38-75% of subjects achieved chest decompression to or beyond baseline. AGD-ACD-CPR provided 6-12% fewer chest compressions/minute than S-CPR group. There was no significant difference in CD, CP, HR, RR and RT within each group comparing both techniques. A simple, inexpensive glove device for ACD-CPR improved chest decompression with emphasis on active pull in manikins without excessive rescuer fatigue. The clinical implication of fewer compressions/minute in the AGD group needs to be evaluated.

  7. A HIGHLY COLLIMATED WATER MASER BIPOLAR OUTFLOW IN THE CEPHEUS A HW3d MASSIVE YOUNG STELLAR OBJECT

    Energy Technology Data Exchange (ETDEWEB)

    Chibueze, James O.; Imai, Hiroshi; Tafoya, Daniel; Omodaka, Toshihiro; Chong, Sze-Ning [Department of Physics and Astronomy, Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065 (Japan); Kameya, Osamu; Hirota, Tomoya [Mizusawa VLBI Observatory, National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Torrelles, Jose M., E-mail: james@milkyway.sci.kagoshima-u.ac.jp [Instituto de Ciencias del Espacio (CSIC)-UB/IEEC, Facultat de Fisica, Universitat de Barcelona, Marti i Franques 1, E-08028 Barcelona (Spain)

    2012-04-01

    We present the results of multi-epoch very long baseline interferometry (VLBI) water (H{sub 2}O) maser observations carried out with the VLBI Exploration of Radio Astrometry toward the Cepheus A HW3d object. We measured for the first time relative proper motions of the H{sub 2}O maser features, whose spatio-kinematics traces a compact bipolar outflow. This outflow looks highly collimated and expanding through {approx}280 AU (400 mas) at a mean velocity of {approx}21 km s{sup -1} ({approx}6 mas yr{sup -1}) without taking into account the turbulent central maser cluster. The opening angle of the outflow is estimated to be {approx}30 Degree-Sign . The dynamical timescale of the outflow is estimated to be {approx}100 years. Our results provide strong support that HW3d harbors an internal massive young star, and the observed outflow could be tracing a very early phase of star formation. We also have analyzed Very Large Array archive data of 1.3 cm continuum emission obtained in 1995 and 2006 toward Cepheus A. The comparative result of the HW3d continuum emission suggests the possibility of the existence of distinct young stellar objects in HW3d and/or strong variability in one of their radio continuum emission components.

  8. Interior HW^{1,p} estimates for divergence degenerate elliptic systems in Carnot groups

    CERN Document Server

    Zhu, Maochun; Niu, Pengcheng

    2012-01-01

    Let X_1,...,X_q be the basis of the space of horizontal vector fields on a homogeneous Carnot group in R^n (qHW^{1,p} estimates (2

  9. Production and properties of biosurfactants from a newly isolated Pseudomonas fluorescens HW-6 growing on hexandecane

    Energy Technology Data Exchange (ETDEWEB)

    Vasileva-Tonkova, E.; Galabova, D. [Bulgarian Academy of Sciences, Dept. of Microbial Biochemistry, Sofia (Bulgaria); Stoimenova, E.; Lalchev, Z. [Dept. of Biochemistry, Sofia Univ. ' ' St. Kliment Ohridski' ' , Sofia (Bulgaria)

    2006-07-15

    The newly isolated from industrial wastewater Pseudomonas fluorescens strain HW-6 produced glycolipid biosurfactants at high concentrations (1.4-2.0 g 1{sup -1}) when grown on hexadecane as a sole carbon source. Biosurfactants decreased the surface tension of the air/water interface by 35 mN m{sup -1} and possessed a low critical micelle concentration value of 20 mg 1{sup -1}, which indicated high surface activity. They efficiently emulsified aromatic hydrocarbons, kerosene, n-paraffins and mineral oils. Biosurfactant production contributed to a significant increase in cell hydrophobicity correlated with an increased growth of the strain on hexadecane. The results suggested that the newly isolated strain of Ps. fluorescens and produced glycolipid biosurfactants with effective surface and emulsifying properties are very promising and could find application for bioremediation of hydrocarbon-polluted sites. (orig.)

  10. k194hw.m77t and k194hw.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-1-94-HW in Mamala Bay, Offshore Honolulu, Oahu, Hawaii from 05/10/1994 to 05/16/1994

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of the U.S. Geological Survey cruise K-1-94-HW. The cruise was conducted in Oahu,...

  11. k193hw.m77t and k193hw.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-1-93-HW in Oahu, Hawaii from 02/20/1993 to 02/26/1993

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of the U.S. Geological Survey cruise K-1-93-HW. The cruise was conducted in Oahu,...

  12. k293hw.m77t and k293hw.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-2-93-HW in Kauai, Hawaii from 02/27/1993 to 03/02/1993

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with GPS navigation data was collected as part of the U.S. Geological Survey cruise K-2-93-HW. The cruise was conducted in Kauai,...

  13. k195hw.m77t and k195hw.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-1-95-HW in in Hawaii from 06/14/1995 to 06/18/1995

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of the U.S. Geological Survey cruise K-1-95-HW. The cruise was conducted in Oahu,...

  14. k294hw.m77t and k294hw.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-2-94-HW in Mamala Bay, Offshore Honolulu, Oahu, Hawaii from 05/16/1994 to 05/23/1994

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of the U.S. Geological Survey cruise K-2-94-HW. The cruise was conducted in Mamala...

  15. k293hw.m77t and k293hw.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-2-93-HW in Kauai, Hawaii from 02/27/1993 to 03/02/1993

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with GPS navigation data was collected as part of the U.S. Geological Survey cruise K-2-93-HW. The cruise was conducted in Kauai,...

  16. k194hw.m77t and k194hw.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-1-94-HW in Mamala Bay, Offshore Honolulu, Oahu, Hawaii from 05/10/1994 to 05/16/1994

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of the U.S. Geological Survey cruise K-1-94-HW. The cruise was conducted in Oahu,...

  17. f786hw.m77t and f786hw.h77t: MGD77T data and header files for single-beam bathymetry data for field activity F-7-86-HW in in Hawaii from 11/28/1986 to 12/20/1986

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with GPS navigation data was collected as part of the U.S. Geological Survey cruise F-7-86-HW. The cruise was conducted in Hawaii...

  18. k294hw.m77t and k294hw.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-2-94-HW in Mamala Bay, Offshore Honolulu, Oahu, Hawaii from 05/16/1994 to 05/23/1994

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of the U.S. Geological Survey cruise K-2-94-HW. The cruise was conducted in Mamala...

  19. k195hw.m77t and k195hw.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-1-95-HW in in Hawaii from 06/14/1995 to 06/18/1995

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of the U.S. Geological Survey cruise K-1-95-HW. The cruise was conducted in Oahu,...

  20. k193hw.m77t and k193hw.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-1-93-HW in Oahu, Hawaii from 02/20/1993 to 02/26/1993

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of the U.S. Geological Survey cruise K-1-93-HW. The cruise was conducted in Oahu,...

  1. Metronome Use for Coordination of Breaths and Cardiac Compressions Delivered by Minimally-Trained Caregivers During Two-Person CPR

    Science.gov (United States)

    Hurst, Victor, IV; West, Sarah; Austin, Paul; Branson, Richard; Beck, George

    2005-01-01

    Astronaut crew medical officers (CMO) aboard the International Space Station (ISS) receive 40 hours of medical training over 18 months before each mission, including two-person cardiopulmonary resuscitation (2CPR) as recommended by the American Heart Association (AHA). Recent studies have concluded that the use of metronomic tones improves the coordination of 2CPR by trained clinicians. 2CPR performance data for minimally-trained caregivers has been limited. The goal of this study was to determine whether use of a metronome by minimally-trained caregivers (CMO analogues) would improve 2CPR performance. 20 pairs of minimally-trained caregivers certified in 2CPR via AHA guidelines performed 2CPR for 4 minutes on an instrumented manikin using 3 interventions: 1) Standard 2CPR without a metronome [NONE], 2) Standard 2CPR plus a metronome for coordinating compression rate only [MET], 3) Standard 2CPR plus a metronome for coordinating both the compression rate and ventilation rate [BOTH]. Caregivers were evaluated for their ability to meet the AHA guideline of 32 breaths-240 compressions in 4 minutes. All (100%) caregivers using the BOTH intervention provided the required number of ventilation breaths as compared with the NONE caregivers (10%) and MET caregivers (0%). For compressions, 97.5% of the BOTH caregivers were not successful in meeting the AHA compression guideline; however, an average of 238 compressions of the desired 240 were completed. None of the caregivers were successful in meeting the compression guideline using the NONE and MET interventions. This study demonstrates that use of metronomic tones by minimally-trained caregivers for coordinating both compressions and breaths improves 2CPR performance. Meeting the breath guideline is important to minimize air entering the stomach, thus decreasing the likelihood of gastric aspiration. These results suggest that manifesting a metronome for the ISS may augment the performance of 2CPR on orbit and thus may

  2. A Systematic Review and Pooled Analysis of CPR-Associated Cardiovascular and Thoracic Injuries

    Science.gov (United States)

    Miller, Andrew C.; Rosati, Shannon F.; Suffredini, Anthony F.; Schrump, David S.

    2014-01-01

    OBJECTIVE The incidence of thoracic injuries resulting from cardiopulmonary resuscitation (CPR) is not well characterized. We describe a case in which a CPR-associated atrial rupture was identified with ultrasound and successfully managed in the intensive care unit with a bedside thoracotomy and atrial repair. We then describe a systematic review with pooled data analysis of CPR-associated cardiovascular, pulmonary, pleural, and thoracic wall injuries. DATA SOURCES PubMed, Scopus, EMBASE, and Web of Science were searched to identify relevant published studies. Unpublished studies were identified by searching the Australian and New Zealand Clinical Trials Registry, World Health Organization International Clinical Trials Registry Platform, Cochrane Library, ClinicalTrials.gov, Current Controlled Trials, and Google. STUDY SELECTION Inclusion criteria for the pooled analysis were any clinical or autopsy study in which a) patients underwent cardiopulmonary resuscitation, b) chest compressions were administered either manually or with the assistance of active compression-decompression devices, and c) autopsy or dedicated imaging assessments were conducted to identify complications. Exclusion criteria for the pooled analysis were pre-clinical studies, case reports and abstracts. DATA EXTRACTION Nine-hundred twenty-eight potentially relevant references were identified. Twenty-seven references met inclusion criteria. DATA SYNTHESIS A systematic review of the literature is provided with pooled data analysis. CONCLUSIONS The incidence of reported CPR-associated cardiovascular and thoracic wall injuries varies widely. CPR with active compression-decompression devices has a higher reported incidence of cardiopulmonary injuries. Bedside ultrasound may be a useful adjunct to assess and risk-stratify patients to identify serious or life-threatening CPR-associated injuries. PMID:24525116

  3. Automated cardiopulmonary resuscitation using a load-distributing band external cardiac support device for in-hospital cardiac arrest: a single centre experience of AutoPulse-CPR.

    Science.gov (United States)

    Spiro, J R; White, S; Quinn, N; Gubran, C J; Ludman, P F; Townend, J N; Doshi, S N

    2015-02-01

    Poor quality cardiopulmonary resuscitation (CPR) predicts adverse outcome. During invasive cardiac procedures automated-CPR (A-CPR) may help maintain effective resuscitation. The use of A-CPR following in-hospital cardiac arrest (IHCA) remains poorly described. Firstly, we aimed to assess the efficiency of healthcare staff using A-CPR in a cardiac arrest scenario at baseline, following re-training and over time (Scenario-based training). Secondly, we studied our clinical experience of A-CPR at our institution over a 2-year period, with particular emphasis on the details of invasive cardiac procedures performed, problems encountered, resuscitation rates and in-hospital outcome (AutoPulse-CPR Registry). Scenario-based training: Forty healthcare professionals were assessed. At baseline, time-to-position device was slow (mean 59 (±24) s (range 15-96s)), with the majority (57%) unable to mode-switch. Following re-training time-to-position reduced (28 (±9) s, pCPR Registry: 285 patients suffered IHCA, 25 received A-CPR. Survival to hospital discharge following conventional CPR was 28/260 (11%) and 7/25 (28%) following A-CPR. A-CPR supported invasive procedures in 9 patients, 2 of whom had A-CPR dependant circulation during transfer to the catheter lab. A-CPR may provide excellent haemodynamic support and facilitate simultaneous invasive cardiac procedures. A significant learning curve exists when integrating A-CPR into clinical practice. Further studies are required to better define the role and effectiveness of A-CPR following IHCA. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  4. Correlation of Serum CPR to Plasma Glucose Ratio with Various Indices of Insulin Secretion and Diseases Duration in Type 2 Diabetes

    OpenAIRE

    2013-01-01

    Evaluating insulin secretion ability and sensitivity is essential to establish an appropriate treatment for patients with type 2 diabetes. The serum C-peptide response (CPR) level is used to evaluate the quantity of endogenous insulin secretion. However, the serum CPR level alone cannot indicate insulin-secretion ability or insulin sensitivity, because plasma glucose levels influence endogenous insulin secretion and vice versa.The CPR index, a ratio of serum CPR level to plasma glucose concen...

  5. Tribolium castaneum RR-1 cuticular protein TcCPR4 is required for formation of pore canals in rigid cuticle.

    Directory of Open Access Journals (Sweden)

    Mi Young Noh

    2015-02-01

    Full Text Available Insect cuticle is composed mainly of structural proteins and the polysaccharide chitin. The CPR family is the largest family of cuticle proteins (CPs, which can be further divided into three subgroups based on the presence of one of the three presumptive chitin-binding sequence motifs denoted as Rebers-Riddiford (R&R consensus sequence motifs RR-1, RR-2 and RR-3. The TcCPR27 protein containing the RR-2 motif is one of the most abundant CPs present both in the horizontal laminae and in vertical pore canals in the procuticle of rigid cuticle found in the elytron of the red flour beetle, Tribolium castaneum. Depletion of TcCPR27 by RNA interference (RNAi causes both unorganized laminae and pore canals, resulting in malformation and weakening of the elytron. In this study, we investigated the function(s of another CP, TcCPR4, which contains the RR-1 motif and is easily extractable from elytra after RNAi to deplete the level of TcCPR27. Transcript levels of the TcCPR4 gene are dramatically increased in 3 d-old pupae when adult cuticle synthesis begins. Immunohistochemical studies revealed that TcCPR4 protein is present in the rigid cuticles of the dorsal elytron, ventral abdomen and leg but not in the flexible cuticles of the hindwing and dorsal abdomen of adult T. castaneum. Immunogold labeling and transmission electron microscopic analyses revealed that TcCPR4 is predominantly localized in pore canals and regions around the apical plasma membrane protrusions into the procuticle of rigid adult cuticles. RNAi for TcCPR4 resulted in an abnormal shape of the pore canals with amorphous pore canal fibers (PCFs in their lumen. These results support the hypothesis that TcCPR4 is required for achieving proper morphology of the vertical pore canals and PCFs that contribute to the assembly of a cuticle that is both lightweight and rigid.

  6. Accident Analysis of Chinese CPR1000 in Response to Station Blackout

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Juyoul [FNC Technology Co., Yongin (Korea, Republic of); Cilliers, Anthonie [North-West University, Potchefstroom (South Africa)

    2016-10-15

    Stress tests required evaluation of the consequences of loss of safety functions from any initiating event (e.g., earthquake or flooding) causing loss of electrical power, including station blackout (SBO). The SBO scenario involves a loss of offsite power, failure of the redundant emergency diesel generators, failure of alternate current (AC) power restoration and the eventual degradation of the reactor coolant pump (RCP) seals resulting in a long term loss of coolant. Using PCTRAN/CPR1000, this study analyses the station blackout on a Chinese CPR1000 which is the most representative type reactor in terms of number of reactors, operating period, power capacity and geological distance from Korean Peninsula. Both the physical effects of the accidents as well as the releases of radioisotopes are calculated and discussed. Station blackout simulation was conducted in this study. The resulting effects seen are consistent with other stress test station blackout tests used utilizing licensed simulation codes. An exact comparison is however not possible as the plants on which the simulations was done vary greatly and the limitations of availability to Chinese FSAR. PCTRAN/CPR1000 is an extremely useful simulation package that provides engineers and scientists very accurate feedback to how a nuclear power plant would react as a whole under various plant conditions. It is able to do this extremely fast as well. As a training tool PCTRAN/CPR1000 provides hands-on experience with many of the primary plant operations and develops an intuitive understanding of the plant.

  7. Apps4CPR: A review study of mobile applications for cardiopulmonary resuscitation training and support

    OpenAIRE

    Kalz, Marco

    2013-01-01

    Kalz, M. (2013, 23 September). Apps4CPR: A review study of mobile applications for cardiopulmonary resuscitation training and support. Presentation given during the 6th World Congress on Social Media, Mobile Apps and Internet/Web 2.0 in Medicine, Health, and Biomedical Research, London, UK.

  8. Evaluation of a Brief Intervention Designed to Increase CPR Training among Pregnant Pool Owners

    Science.gov (United States)

    Girasek, Deborah C.

    2011-01-01

    This study evaluated whether a brief videotape could motivate pregnant pool owners to be trained in infant/child cardiopulmonary resuscitation (CPR). Women were recruited from prenatal classes in South Florida. Eligible volunteers were randomized to view a video or receive standard treatment, after completing a questionnaire. The video explained…

  9. Classroom versus Computer-Based CPR Training: A Comparison of the Effectiveness of Two Instructional Methods

    Science.gov (United States)

    Rehberg, Robb S.; Gazzillo Diaz, Linda; Middlemas, David A.

    2009-01-01

    Objective: The objective of this study was to determine whether computer-based CPR training is comparable to traditional classroom training. Design and Setting: This study was quantitative in design. Data was gathered from a standardized examination and skill performance evaluation which yielded numerical scores. Subjects: The subjects were 64…

  10. CPR in the Schools: Training Students to Save Heart Attack Victims.

    Science.gov (United States)

    Britton, Royce J.

    1978-01-01

    A community cardiac emergency medical plan should include training of family and co-workers of high risk patients, including teenage students. The American Heart Association lists ways to introduce cardiopulmonary resuscitation (CPR) into school curricula and describes the plan implemented in Pennsylvania. (MF)

  11. Evaluation of a Brief Intervention Designed to Increase CPR Training among Pregnant Pool Owners

    Science.gov (United States)

    Girasek, Deborah C.

    2011-01-01

    This study evaluated whether a brief videotape could motivate pregnant pool owners to be trained in infant/child cardiopulmonary resuscitation (CPR). Women were recruited from prenatal classes in South Florida. Eligible volunteers were randomized to view a video or receive standard treatment, after completing a questionnaire. The video explained…

  12. Neurologisches Outcome nach CPR bei schockresistentem Kammerflimmern unter Gabe von Sedacoron(R

    Directory of Open Access Journals (Sweden)

    Müller R

    2003-01-01

    Full Text Available Bei einer protrahierten CPR mit schockresistentem Kammerflimmern kann unter Gabe von Sedacoron(R ein zufriedenstellender internistischer Zustand erreicht werden. Neurologisch bleiben nach 6 Wochen geringe Defizite des Kurzzeitgedächtnisses. Der Autor regt mit dieser Kasuistik eine Fortsetzung der ARREST- und der ALIVE-Studie an, wobei das neurologische Outcome Beachtung finden sollte.

  13. Does use of the CPREzy involve more work than CPR without feedback?

    NARCIS (Netherlands)

    Berkom, P.F. van; Noordergraaf, G.J.; Scheffer, G.J.; Noordergraaf, A.

    2008-01-01

    AIM: Feedback during CPR may facilitate quality in chest compressions, but has also been associated with caregiver complaints such as stiff wrists, the need for more force and increased fatigue. This concern about extra work is, when using the CPREzy with its own spring-loaded surface, particularly

  14. Apps4CPR: A review study of mobile applications for cardiopulmonary resuscitation training and support

    NARCIS (Netherlands)

    Kalz, Marco

    2013-01-01

    Kalz, M. (2013, 23 September). Apps4CPR: A review study of mobile applications for cardiopulmonary resuscitation training and support. Presentation given during the 6th World Congress on Social Media, Mobile Apps and Internet/Web 2.0 in Medicine, Health, and Biomedical Research, London, UK.

  15. Does use of the CPREzy involve more work than CPR without feedback?

    NARCIS (Netherlands)

    Berkom, P.F. van; Noordergraaf, G.J.; Scheffer, G.J.; Noordergraaf, A.

    2008-01-01

    AIM: Feedback during CPR may facilitate quality in chest compressions, but has also been associated with caregiver complaints such as stiff wrists, the need for more force and increased fatigue. This concern about extra work is, when using the CPREzy with its own spring-loaded surface, particularly

  16. Emergency Victim Care. A Training Manual for Emergency Medical Technicians. Module 5. CPR, Oxygen Therapy. Revised.

    Science.gov (United States)

    Ohio State Dept. of Education, Columbus. Div. of Vocational Education.

    This student manual, the fifth in a set of 14 modules, is designed to train emergency medical technicians (EMTs) in Ohio. The module contains two sections covering the following course content; cardiopulmonary resuscitation (CPR) (including artificial ventilation, foreign body obstructions, adjunctive equipment and special techniques, artificial…

  17. Training and Confidence Level of Junior Anaesthetists in CPR- Experience in A Developing Country

    Directory of Open Access Journals (Sweden)

    Desalu Ibironke

    2008-01-01

    There is low confidence among junior anaesthetists in Nigeria in performance of CPR, poor knowledge of ECG interpretation of cardiac arrest rhythm and little practice in defibrillation. The establishment of a Resuscitation council would ensure adequate and frequent training which would improve knowledge, boost confidence and result in better patient care.

  18. Decarbonylated cyclophilin A Cpr1 protein protects Saccharomyces cerevisiae KNU5377Y when exposed to stress induced by menadione.

    Science.gov (United States)

    Kim, Il-Sup; Jin, Ingnyol; Yoon, Ho-Sung

    2011-01-01

    Cyclophilins are conserved cis-trans peptidyl-prolyl isomerase that are implicated in protein folding and function as molecular chaperones. The accumulation of Cpr1 protein to menadione in Saccharomyces cerevisiae KNU5377Y suggests a possibility that this protein may participate in the mechanism of stress tolerance. Stress response of S. cerevisiae KNU5377Y cpr1Δ mutant strain was investigated in the presence of menadione (MD). The growth ability of the strain was confirmed in an oxidant-supplemented medium, and a relationship was established between diminishing levels of cell rescue enzymes and MD sensitivity. The results demonstrate the significant effect of CPR1 disruption in the cellular growth rate, cell viability and morphology, and redox state in the presence of MD and suggest the possible role of Cpr1p in acquiring sensitivity to MD and its physiological role in cellular stress tolerance. The in vivo importance of Cpr1p for antioxidant-mediated reactive oxygen species (ROS) neutralization and chaperone-mediated protein folding was confirmed by analyzing the expression changes of a variety of cell rescue proteins in a CPR1-disrupted strain. The cpr1Δ to the exogenous MD showed reduced expression level of antioxidant enzymes, molecular chaperones, and metabolic enzymes such as nicotinamide adenine dinucleotide phosphate (NADPH)- or adenosine triphosphate (ATP)-generating systems. More importantly, it was shown that cpr1Δ mutant caused imbalance in the cellular redox homeostasis and increased ROS levels in the cytosol as well as mitochondria and elevated iron concentrations. As a result of excess ROS production, the cpr1Δ mutant provoked an increase in oxidative damage and a reduction in antioxidant activity and free radical scavenger ability. However, there was no difference in the stress responses between the wild-type and the cpr1Δ mutant strains derived from S. cerevisiae BY4741 as a control strain under the same stress. Unlike BY4741, KNU5377Y Cpr1

  19. Association between Prehospital CPR Quality and End-Tidal Carbon Dioxide Levels in Out-of-Hospital Cardiac Arrest.

    Science.gov (United States)

    Murphy, Ryan A; Bobrow, Bentley J; Spaite, Daniel W; Hu, Chengcheng; McDannold, Robyn; Vadeboncoeur, Tyler F

    2016-01-01

    International Guidelines recommend measurement of end-tidal carbon dioxide (EtCO2) to enhance cardiopulmonary resuscitation (CPR) quality and optimize blood flow during CPR. Numerous factors impact EtCO2 (e.g., ventilation, metabolism, cardiac output), yet few clinical studies have correlated CPR quality and EtCO2 during actual out-of-hospital cardiac arrest (OHCA) resuscitations. The purpose of this study was to describe the association between EtCO2 and CPR quality variables during OHCA. This is an observational study of prospectively collected CPR quality and capnography data from two EMS agencies participating in a statewide resuscitation quality improvement program. CPR quality and capnography data from adult (≥18 years) cardiac resuscitation attempts (10/2008-06/2013) were collected and analyzed on a minute-by-minute basis using RescueNet™ Code Review. Linear mixed effect models were used to evaluate the association between (log-transformed) EtCO2 level and CPR variables: chest compression (CC) depth, CC rate, CC release velocity (CCRV), ventilation rate. Among the 1217 adult OHCA cases of presumed cardiac etiology, 925 (76.0%) had a monitor-defibrillator file with CPR quality data, of which 296 (32.0%) cases had >1 minute of capnography data during CPR. After capnography quality review, 66 of these cases (22.3%) were excluded due to uninterpretable capnography, resulting in a final study sample of 230 subjects (mean age 68 years; 69.1% male), with a total of 1581 minutes of data. After adjustment for other CPR variables, a 10 mm increase in CC depth was associated with a 4.0% increase in EtCO2 (p < 0.0001), a 10 compression/minute increase in CC rate with a 1.7% increase in EtCO2 (p = 0.02), a 10 mm/second increase in CCRV with a 2.8% increase in EtCO2 (p = 0.03), and a 10 breath/minute increase in ventilation rate with a 17.4% decrease in EtCO2 (p < 0.0001). When controlling for known CPR quality variables, increases in CC depth, CC rate and CCRV

  20. Factors influencing performance of cardiopulmonary resuscitation (CPR) by Foundation Year 1 hospital doctors.

    Science.gov (United States)

    Sayee, Nicole; McCluskey, David

    2012-01-01

    Foundation Year One (FY1) doctors are often the first medical staff responders at in-hospital cardiac arrests. The study objectives were to assess the cardiopulmonary resuscitation (CPR) skills of FY1 doctors at a Belfast teaching hospital and to highlight factors that influence their performance. A group of FY1 doctors working in a Belfast teaching hospital were asked to participate in this study. These junior doctors were regularly on-call for acute medical emergencies including cardiac arrest. Participants were instructed to perform two, 3 minute sessions of CPR on a skills reporter manikin. Each session was separated by a 5 minute rest period, one session using a compression-to-ventilation ratio of 15:2 and the other using a ratio of 30:2. Performance was gauged both objectively, by measuring the depth of chest compressions, and subjectively by a panel of 5 Advanced Life Support (ALS) instructors who reviewed the tracings of each CPR session. Overall, 85% of medical FY1's working in the hospital participated in the study. Objective results determined that males performed significantly better than their female counterparts using both the 15:2 and 30:2 ratios. The male FY1 doctors performed equally well using both 15:2 and 30:2 ratios, in comparison to female doctors who were noted to be better using the 15:2 ratio. Individuals with a Body mass index (BMI) greater than the mean for the group, performed significantly better than those with a lower BMI when using the 30:2 ratio. BMI was an important factor and correlated with chest compression depth. Females with a low BMI performed less well when using a ratio of 30:2. Overall, expert opinion significantly favoured the 15:2 ratio for the FY1 doctor group. CPR performance can be influenced by factors such as gender and BMI, as such the individual rescuer should take these into account when determining which compression to ventilation ration to perform in order to maximise patient outcome. This study showed that

  1. Telephone CPR Instructions in Emergency Dispatch Systems: Qualitative Survey of 911 Call Centers

    Directory of Open Access Journals (Sweden)

    John Sutter

    2015-10-01

    Full Text Available Introduction: Out-of-hospital cardiac arrest (OHCA is a leading cause of death. The 2010 American Heart Association Emergency Cardiovascular Care (ECC Guidelines recognize emergency dispatch as an integral component of emergency medical service response to OHCA and call for all dispatchers to be trained to provide telephone cardiopulmonary resuscitation (T-CPR pre-arrival instructions. To begin to measure and improve this critical intervention, this study describes a nationwide survey of public safety answering points (PSAPs focusing on the current practices and resources available to provide T-CPR to callers with the overall goal of improving survival from OHCA. Methods: We conducted this survey in 2010, identifying 5,686 PSAPs; 3,555 had valid e-mail addresses and were contacted. Each received a preliminary e-mail announcing the survey, an e-mail with a link to the survey, and up to three follow-up e-mails for non-responders. The survey contained 23 primary questions with sub-questions depending on the response selected. Results: Of the 5,686 identified PSAPs in the United States, 3,555 (63% received the survey, with 1,924/3,555 (54% responding. Nearly all were public agencies (n=1,888, 98%. Eight hundred seventy-eight (46% responding agencies reported that they provide no instructions for medical emergencies, and 273 (14% reported that they are unable to transfer callers to another facility to provide T-CPR. Of the 1,924 respondents, 975 (51% reported that they provide pre-arrival instructions for OHCA: 67 (3% provide compression-only CPR instructions, 699 (36% reported traditional CPR instructions (chest compressions with rescue breathing, 166 (9% reported some other instructions incorporating ventilations and compressions, and 92 (5% did not specify the type of instructions provided. A validation follow up showed no substantial difference in the provision of instructions for OHCA by non-responders to the survey. Conclusion: This is the

  2. Nanomorph Silicon Thin Films Prepared by Using an HW-MWECR CVD System

    Institute of Scientific and Technical Information of China (English)

    HU Yue-Hui; MA Zhan-Jie; ZHOU Huai-En; ZHU Xiu-Hong; CHEN Guang-Hua; ZHOU Jian-Er; RONG Yan-Dong; LI Ying; SONG Xue-Mei; ZHANG Wen-Li; DING Yi; GAO Zhuo

    2005-01-01

    @@ We have prepared hydrogenated nano-amorph silicon (na-Si:H) films by using a hot-wire-assisted microwave electron-cyclotron-resonance (HW-MWECR) chemical vapour deposition (CVD) system. The films are deposited in two steps: in the first 9min, a hydrogenated amorphous silicon layer is deposited by using hydrogen-diluted silane with a concentration of SiH4/(SiH4+H2) = 20%, and then a nanocrystalline silicon (nc-Si) layer is deposited by using various highly hydrogen-diluted silane. The Raman TO-like mode peak of the films was found in the range 497-508 cm-1. When the silane concentration used for preparation of the nc-Si layer is 14.3%, the film has a large crystalline volume fraction of 65.4%, a wide optical band gap of 1.89eV and a low hydrogen content of 9.5at.%. Moreover, the na-Si:H films rather than nc-Si possess high photosensitivity of about 15.

  3. Design of the RINSE Trial: The Rapid Infusion of cold Normal Saline by paramedics during CPR

    Directory of Open Access Journals (Sweden)

    Jacobs Ian

    2011-10-01

    Full Text Available Abstract Background The International Liaison Committee on Resuscitation (ILCOR now recommends therapeutic hypothermia (TH (33°C for 12-24 hours as soon as possible for patients who remain comatose after resuscitation from shockable rhythm in out-of-hospital cardiac arrest and that it be considered for non shockable rhythms. The optimal timing of TH is still uncertain. Laboratory data have suggested that there is significantly decreased neurological injury if cooling is initiated during CPR. In addition, peri-arrest cooling may increase the rate of successful defibrillation. This study aims to determine whether paramedic cooling during CPR improves outcome compared standard treatment in patients who are being resuscitated from out-of-hospital cardiac arrest. Methods/Design This paper describes the methodology for a definitive multi-centre, randomised, controlled trial of paramedic cooling during CPR compared with standard treatment. Paramedic cooling during CPR will be achieved using a rapid infusion of large volume (20-40 mL/kg to a maximum of 2 litres ice-cold (4°C normal saline. The primary outcome measure is survival at hospital discharge. Secondary outcome measures are rates of return of spontaneous circulation, rate of survival to hospital admission, temperature on arrival at hospital, and 12 month quality of life of survivors. Discussion This trial will test the effect of the administration of ice cold saline during CPR on survival outcomes. If this simple treatment is found to improve outcomes, it will have generalisability to prehospital services globally. Trial Registration ClinicalTrials.gov: NCT01172678

  4. Progress Towards a Global Understanding of Plankton Dynamics: The Global Alliance of CPR Surveys (GACS)

    Science.gov (United States)

    Batten, S.; Richardson, A.; Melrose, C.; Muxagata, E.; Hosie, G.; Verheye, H.; Hall, J.; Edwards, M.; Koubbi, P.; Abu-Alhaija, R.; Chiba, S.; Wilson, W.; Nagappa, R.; Takahashi, K.

    2016-02-01

    The Continuous Plankton Recorder (CPR) was first used in 1931 to routinely sample plankton and its continued deployment now sustains the longest-running, and spatially most extensive marine biological sampling programme in the world. Towed behind, for the most part commercial, ships it collects plankton samples from the surface waters that are subsequently analysed to provide taxonomically-resolved abundance data on a broad range of planktonic organisms from the size of coccolithophores to euphausiids. Plankton appear to integrate changes in the physical environment and by underpinning most marine food-webs, pass on this variability to higher trophic levels which have societal value. CPRs are deployed increasingly around the globe in discrete regional surveys that until recently interacted in an informal way. In 2011 the Global Alliance of CPR Surveys (GACS) was launched to bring these surveys together to collaborate more productively and address issues such as: methodological standardization, data integration, capacity building, and data analysis. Early products include a combined global database and regularly-released global marine ecological status reports. There are, of course, limitations to the exploitation of CPR data as well as the current geographic coverage. A current focus of GACS is integration of the data with models to meaningfully extrapolate across time and space. In this way the output could be used to provide more robust synoptic representations of key plankton variables. Recent years have also seen the CPR used as a platform in itself with the inclusion of additional sensors and water samplers that can sample the microplankton. The archive of samples has already been used for some molecular investigations and curation of samples is maintained for future studies. Thus the CPR is a key element of any regional to global ocean observing system of biodiversity.

  5. A randomized trial on elderly laypersons' CPR performance in a realistic cardiac arrest simulation.

    Science.gov (United States)

    Neset, A; Birkenes, T S; Furunes, T; Myklebust, He; Mykletun, R J; Odegaard, S; Olasveengen, T M; Kramer-Johansen, J

    2012-01-01

    Bystander cardiopulmonary resuscitation (CPR) is important for survival after cardiac arrest. We hypothesized that elderly laypersons would perform CPR poorer in a realistic cardiac arrest simulation, compared to a traditional test. Sixty-four lay rescuers aged 50-75 were randomized to realistic or traditional test, both with ten minutes of telephone assisted CPR. Realistic simulation started suddenly without warning, leaving the test subject alone in a confined and noisy apartment. Traditional test was conducted in a spacious and calm classroom with a researcher present. CPR performance was recorded with a manikin with human like chest properties. Heart rate and self-reported exhaustion were registered. CPR quality was not different in the two groups: compression depth, 43 mm ± 7 versus 43 ± 4, P = 0.72; compressions rate, 97 min(-1) ± 11 versus 93 ± 15, P = 0.26; ventilation rate, 2.4 min(-1) ± 1.7 versus 2.8 ± 1.1, P = 0.35; and hands-off time 273 s ± 50 versus 270 ± 66, P = 0.82; in realistic (n = 31) and traditional (n = 33) groups, respectively. No fatigue was evident in the repeated measures analysis of variance. Work load was not different between the groups; attained percentage of age predicted maximum heart rate, 73% ± 9 and 76 ± 11, P = 0.37, reported exhaustion 43 ± 21 (scale: 0 to 100) and 37 ± 19, P = 0.24. Elderly lay people are capable of performing chest compressions with acceptable quality for ten minutes in a realistic cardiac arrest simulation. Ventilation quality and hands-off time were not adequate in either group. © 2011 The Authors Acta Anaesthesiologica Scandinavica © 2011 The Acta Anaesthesiologica Scandinavica Foundation.

  6. CPR PRO® device reduces rescuer fatigue during continuous chest compression cardiopulmonary resuscitation: a randomized crossover trial using a manikin model.

    Science.gov (United States)

    Kovic, Ivor; Lulic, Dinka; Lulic, Ileana

    2013-10-01

    The performance of high-quality chest compressions with minimal interruptions is one of the most important elements of the "Chain of Survival." To evaluate the impact of a novel CPR PRO(®) (CPRO) device for manual chest compression on rescuer fatigue, pain, and cardiopulmonary resuscitation (CPR) quality. Randomized crossover trial of 24 health care professionals performing continuous chest compression CPR for 10 min with a CPRO device and conventional manual CPR (MCPR). Data about chest compressions were recorded using a manikin. Rescuers' physiologic signs were recorded before and after each session, and heart rate (HR) data were tracked continuously. Fatigue was assessed with ratings of perceived exertion, and pain questionnaire. All subjects completed 10 min of CPR with both methods. Significantly more rest breaks were taken during MCPR sessions (1.7 ± 2 vs. 0.21 ± 0.72). Subjects' perceived exertion was higher after MCPR, as well as the average (120.7 ± 16.8 vs. 110.8 ± 17.6) and maximal HR (134.3 ± 18.5 vs. 123.42 ± 16.5) during testing. Subjects reported more pain in the hands, especially the wrist, after performing MCPR. Average depth of compressions was higher with the CPRO device (4.6 ± 7.0 vs. 4.3 ± 7.9) and declined more slowly over time. Other CPR quality parameters, such as the correct position and complete release of pressure, were also better for CPRO CPR. CPRO device reduces rescuer fatigue and pain during continuous chest compression CPR, which results in a higher quality of CPR in a simulation setting. Copyright © 2013 Elsevier Inc. All rights reserved.

  7. Effects of pre-training using serious game technology on CPR performance--an exploratory quasi-experimental transfer study

    National Research Council Canada - National Science Library

    Creutzfeldt, Johan; Hedman, Leif; Felländer-Tsai, Li

    2012-01-01

    .... This study aims to explore medical students' retention of knowledge and skills as well as their proficiency gain after pre-training using a MVW with avatars for cardio-pulmonary resuscitation (CPR) team training...

  8. Guidance for ambulance personnel on decisions and situations related to out-of-hospital CPR.

    Science.gov (United States)

    Ågård, Anders; Herlitz, Johan; Castrén, Maaret; Jonsson, Lars; Sandman, Lars

    2012-01-01

    Ethical guidelines on out-of-hospital cardio-pulmonary resuscitation (CPR) are designed to provide substantial guidance for the people who have to make decisions and deal with situations in the real world. The crucial question is whether it is possible to formulate practical guidelines that will make things somewhat easier for ambulance personnel. The aims of this article are to address the ethical aspects related to out-of-hospital CPR, primarily to decisions on not starting or terminating resuscitation attempts, using the views and experience of ambulance personnel as a starting point, and to summarise the key points in a practice guideline on the subject. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  9. Kinematics and dynamics analysis of a novel 2PC-CPR parallel mechanism

    Directory of Open Access Journals (Sweden)

    Sheng Lin

    2016-10-01

    Full Text Available A novel parallel mechanism of two translations and one rotation freedom degrees two-prismatic joint-cylindrical joint-one-cylindrical joint-prismatic joint-revolute joint (2PC-CPR is proposed. The mechanism can be applied to write Chinese characters and to classify productions with the appropriated control. In this article, the kinematics and dynamics analysis are systematically conducted with the following procedure. First of all, the 2PC-CPR parallel mechanism is designed by GF set and the freedom degree of the mechanism is calculated using screw theory. Then the formula for solving the inverse/forward displacement, velocity, and acceleration is derived based on the geometrical constraints. The dynamics model is established by using virtual work principle. Finally, kinematics SimMechanics model is created by the co-simulation of SolidWorks and MATLAB software, and its workspace is analyzed.

  10. CPR Induced Consciousness During Out-of-Hospital Cardiac Arrest: A Case Report on an Emerging Phenomenon.

    Science.gov (United States)

    Pound, Joshua; Verbeek, P Richard; Cheskes, Sheldon

    2017-01-01

    High quality cardiopulmonary resuscitation (CPR) has produced a relatively new phenomenon of consciousness in patients with vital signs absent. Further research is necessary to produce a viable treatment strategy during and post resuscitation. To provide a case study done by paramedics in the field illustrating the need for sedation in a patient whose presentation was consistent with CPR induced consciousness. Resuscitative challenges are provided as well as potential future treatment options to minimize harm to both patients and prehospital providers. A 52-year-old male presented as a witnessed out-of-hospital cardiac arrest (OHCA). During CPR the patient began to exhibit signs of life including severe agitation and thrashing of his limbs while CPR was ongoing for ventricular fibrillation prior to defibrillation. Resuscitation became considerably more complicated due to the violent and counterintuitive motions done by the patient during their own resuscitation. Despite the atypical presentation of cardiac arrest the patient was successfully resuscitated employing high quality CPR, standard advanced life support (ALS) care as well as two double sequential external defibrillation shocks. The patient underwent emergency percutaneous coronary intervention (PCI) for a 100% occlusion of his left anterior descending artery (LAD). The patient returned home 3 days later fully recovered with a Cerebral Performance Score of 1. CPR induced consciousness is emerging as a new phenomenon challenging providers of high quality CPR during cardiac arrest resuscitation. Our case report describes the manifestations of CPR induced consciousness as well as the resuscitative challenges which occur during resuscitation. Further research is required to determine the true frequency of this condition as well as treatment algorithms that would allow for appropriate and safe management for both the patient and EMS providers.

  11. Regions of High Out-Of-Hospital Cardiac Arrest Incidence and Low Bystander CPR Rates in Victoria, Australia

    Science.gov (United States)

    Straney, Lahn D.; Bray, Janet E.; Beck, Ben; Finn, Judith; Bernard, Stephen; Dyson, Kylie; Lijovic, Marijana; Smith, Karen

    2015-01-01

    Background Out-of-hospital cardiac arrest (OHCA) remains a major public health issue and research has shown that large regional variation in outcomes exists. Of the interventions associated with survival, the provision of bystander CPR is one of the most important modifiable factors. The aim of this study is to identify census areas with high incidence of OHCA and low rates of bystander CPR in Victoria, Australia Methods We conducted an observational study using prospectively collected population-based OHCA data from the state of Victoria in Australia. Using ArcGIS (ArcMap 10.0), we linked the location of the arrest using the dispatch coordinates (longitude and latitude) to Victorian Local Government Areas (LGAs). We used Bayesian hierarchical models with random effects on each LGA to provide shrunken estimates of the rates of bystander CPR and the incidence rates. Results Over the study period there were 31,019 adult OHCA attended, of which 21,436 (69.1%) cases were of presumed cardiac etiology. Significant variation in the incidence of OHCA among LGAs was observed. There was a 3 fold difference in the incidence rate between the lowest and highest LGAs, ranging from 38.5 to 115.1 cases per 100,000 person-years. The overall rate of bystander CPR for bystander witnessed OHCAs was 62.4%, with the rate increasing from 56.4% in 2008–2010 to 68.6% in 2010–2013. There was a 25.1% absolute difference in bystander CPR rates between the highest and lowest LGAs. Conclusion Significant regional variation in OHCA incidence and bystander CPR rates exists throughout Victoria. Regions with high incidence and low bystander CPR participation can be identified and would make suitable targets for interventions to improve CPR participation rates. PMID:26447844

  12. Regions of High Out-Of-Hospital Cardiac Arrest Incidence and Low Bystander CPR Rates in Victoria, Australia.

    Directory of Open Access Journals (Sweden)

    Lahn D Straney

    Full Text Available Out-of-hospital cardiac arrest (OHCA remains a major public health issue and research has shown that large regional variation in outcomes exists. Of the interventions associated with survival, the provision of bystander CPR is one of the most important modifiable factors. The aim of this study is to identify census areas with high incidence of OHCA and low rates of bystander CPR in Victoria, Australia.We conducted an observational study using prospectively collected population-based OHCA data from the state of Victoria in Australia. Using ArcGIS (ArcMap 10.0, we linked the location of the arrest using the dispatch coordinates (longitude and latitude to Victorian Local Government Areas (LGAs. We used Bayesian hierarchical models with random effects on each LGA to provide shrunken estimates of the rates of bystander CPR and the incidence rates.Over the study period there were 31,019 adult OHCA attended, of which 21,436 (69.1% cases were of presumed cardiac etiology. Significant variation in the incidence of OHCA among LGAs was observed. There was a 3 fold difference in the incidence rate between the lowest and highest LGAs, ranging from 38.5 to 115.1 cases per 100,000 person-years. The overall rate of bystander CPR for bystander witnessed OHCAs was 62.4%, with the rate increasing from 56.4% in 2008-2010 to 68.6% in 2010-2013. There was a 25.1% absolute difference in bystander CPR rates between the highest and lowest LGAs.Significant regional variation in OHCA incidence and bystander CPR rates exists throughout Victoria. Regions with high incidence and low bystander CPR participation can be identified and would make suitable targets for interventions to improve CPR participation rates.

  13. Decarbonylated cyclophilin A Cpr1 protein protects Saccharomyces cerevisiae KNU5377Y when exposed to stress induced by menadione

    OpenAIRE

    Kim, Il-Sup; Jin, Ingnyol; Yoon, Ho-Sung

    2010-01-01

    Cyclophilins are conserved cis–trans peptidyl-prolyl isomerase that are implicated in protein folding and function as molecular chaperones. The accumulation of Cpr1 protein to menadione in Saccharomyces cerevisiae KNU5377Y suggests a possibility that this protein may participate in the mechanism of stress tolerance. Stress response of S. cerevisiae KNU5377Y cpr1Δ mutant strain was investigated in the presence of menadione (MD). The growth ability of the strain was confirmed in an oxidant-supp...

  14. Regions of High Out-Of-Hospital Cardiac Arrest Incidence and Low Bystander CPR Rates in Victoria, Australia.

    Science.gov (United States)

    Straney, Lahn D; Bray, Janet E; Beck, Ben; Finn, Judith; Bernard, Stephen; Dyson, Kylie; Lijovic, Marijana; Smith, Karen

    2015-01-01

    Out-of-hospital cardiac arrest (OHCA) remains a major public health issue and research has shown that large regional variation in outcomes exists. Of the interventions associated with survival, the provision of bystander CPR is one of the most important modifiable factors. The aim of this study is to identify census areas with high incidence of OHCA and low rates of bystander CPR in Victoria, Australia. We conducted an observational study using prospectively collected population-based OHCA data from the state of Victoria in Australia. Using ArcGIS (ArcMap 10.0), we linked the location of the arrest using the dispatch coordinates (longitude and latitude) to Victorian Local Government Areas (LGAs). We used Bayesian hierarchical models with random effects on each LGA to provide shrunken estimates of the rates of bystander CPR and the incidence rates. Over the study period there were 31,019 adult OHCA attended, of which 21,436 (69.1%) cases were of presumed cardiac etiology. Significant variation in the incidence of OHCA among LGAs was observed. There was a 3 fold difference in the incidence rate between the lowest and highest LGAs, ranging from 38.5 to 115.1 cases per 100,000 person-years. The overall rate of bystander CPR for bystander witnessed OHCAs was 62.4%, with the rate increasing from 56.4% in 2008-2010 to 68.6% in 2010-2013. There was a 25.1% absolute difference in bystander CPR rates between the highest and lowest LGAs. Significant regional variation in OHCA incidence and bystander CPR rates exists throughout Victoria. Regions with high incidence and low bystander CPR participation can be identified and would make suitable targets for interventions to improve CPR participation rates.

  15. A Randomized Controlled Trial of a CPR Decision Support Video for Patients Admitted to the General Medicine Service.

    Science.gov (United States)

    Merino, Aimee M; Greiner, Ryan; Hartwig, Kristopher

    2017-09-01

    Patient preferences regarding cardiopulmonary resuscitation (CPR) are important, especially during hospitalization when a patient's health is changing. Yet many patients are not adequately informed or involved in the decision-making process. We examined the effect of an informational video about CPR on hospitalized patients' code status choices. This was a prospective, randomized trial conducted at the Minneapolis Veterans Affairs Health Care System in Minnesota. We enrolled 119 patients, hospitalized on the general medicine service, and at least 65 years old. The majority were men (97%) with a mean age of 75. A video described code status choices: full code (CPR and intubation if required), do not resuscitate (DNR), and do not resuscitate/do not intubate (DNR/DNI). Participants were randomized to watch the video (n = 59) or usual care (n = 60). The primary outcome was participants' code status preferences. Secondary outcomes included a questionnaire designed to evaluate participants' trust in their healthcare team and knowledge and perceptions about CPR. Participants who viewed the video were less likely to choose full code (37%) compared to participants in the usual care group (71%) and more likely to choose DNR/DNI (56% in the video group vs. 17% in the control group) ( < 0.00001). We did not see a difference in trust in their healthcare team or knowledge and perceptions about CPR as assessed by our questionnaire. Hospitalized patients who watched a video about CPR and code status choices were less likely to choose full code and more likely to choose DNR/DNI.

  16. Arabidopsis CPR5 is a senescence-regulatory gene with pleiotropic functions as predicted by the evolutionary theory of senescence.

    Science.gov (United States)

    Jing, Hai-Chun; Anderson, Lisa; Sturre, Marcel J G; Hille, Jacques; Dijkwel, Paul P

    2007-01-01

    Evolutionary theories of senescence predict that genes with pleiotropic functions are important for senescence regulation. In plants there is no direct molecular genetic test for the existence of such senescence-regulatory genes. Arabidopsis cpr5 mutants exhibit multiple phenotypes including hypersensitivity to various signalling molecules, constitutive expression of pathogen-related genes, abnormal trichome development, spontaneous lesion formation, and accelerated leaf senescence. These indicate that CPR5 is a beneficial gene which controls multiple facets of the Arabidopsis life cycle. Ectopic expression of CPR5 restored all the mutant phenotypes. However, in transgenic plants with increased CPR5 transcripts, accelerated leaf senescence was observed in detached leaves and at late development around 50 d after germination, as illustrated by the earlier onset of senescence-associated physiological and molecular markers. Thus, CPR5 has early-life beneficial effects by repressing cell death and insuring normal plant development, but late-life deleterious effects by promoting developmental senescence. As such, CPR5 appears to function as a typical senescence-regulatory gene as predicted by the evolutionary theories of senescence.

  17. Extensive gene amplification and concerted evolution within the CPR family of cuticular proteins in mosquitoes.

    Science.gov (United States)

    Cornman, R Scott; Willis, Judith H

    2008-06-01

    Annotation of the Anopheles gambiae genome has revealed a large increase in the number of genes encoding cuticular proteins with the Rebers and Riddiford Consensus (the CPR gene family) relative to Drosophila melanogaster. This increase reflects an expansion of the RR-2 group of CPR genes, particularly the amplification of sets of highly similar paralogs. Patterns of nucleotide variation indicate that extensive concerted evolution is occurring within these clusters. The pattern of concerted evolution is complex, however, as sequence similarity within clusters is uncorrelated with gene order and orientation, and no comparable clusters occur within similarly compact arrays of the RR-1 group in mosquitoes or in either group in D. melanogaster. The dearth of pseudogenes suggests that sequence clusters are maintained by selection for high gene-copy number, perhaps due to selection for high expression rates. This hypothesis is consistent with the apparently parallel evolution of compact gene architectures within sequence clusters relative to single-copy genes. We show that RR-2 proteins from sequence-cluster genes have complex repeats and extreme amino-acid compositions relative to single-copy CPR proteins in An. gambiae, and that the amino-acid composition of the N-terminal and C-terminal sequence flanking the chitin-binding consensus region evolves in a correlated fashion.

  18. Rescuer-limited cardiopulmonary resuscitation as an alternative to 2-min switched CPR in the setting of inhospital cardiac arrest: a randomised cross-over study.

    Science.gov (United States)

    Jo, Choong Hyun; Cho, Gyu Chong; Ahn, Jung Hwan; Park, Yoo Seok; Lee, Chang Hee

    2015-07-01

    The 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation (CPR) recommend that chest compression be rotated every 2 min to prevent rescuer fatigue. However, the quality of chest compression using 2-min switched CPR tends to decrease rapidly due to rescuer fatigue. We aimed to compare the effectiveness of use of 2-min switched CPR and rescuer-limited CPR (the person performing compressions is allowed to switch with another rescuer prior to 2 min if feeling fatigued) in the setting of inhospital cardiac arrest. Using a randomised cross-over trial design, 90 medical students were grouped into pairs to perform four cycles of 2-min switched CPR and rescuer-limited CPR (495 s per technique). During each trial, the total number of compressions performed, mean depth of compression and proportion of effective compressions performed (compression depth >5 mm) were recorded for identification of significant differences and changes in pulse rate and RR were measured to determine the extent of exhaustion. Compared with 2-min switched CPR, the mean compression was deeper (51 vs 47 mm, pCPR. Subgroup analysis by 30-s unit showed more consistent compression quality during rescuer-limited CPR. No significant differences in change in pulse rate and RR were found between the two techniques. Rescuer-limited CPR yields a greater number of effective compressions and more consistent quality of CPR than 2-min switched CPR. Rescuer-limited CPR might be a suitable alternative for treating inhospital cardiac arrest. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  19. l583hw.m77t - MGD77 data file for Geophysical data from field activity L-5-83-HW in Horizon Guyot, Necker Ridge, Hawaii, Johnston, Palmyra, Kingman Island from 10/29/1983 to 11/26/1983

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of field activity L-5-83-HW in Horizon Guyot, Necker Ridge, Hawaii, Johnston,...

  20. l583hw.m77t - MGD77 data file for Geophysical data from field activity L-5-83-HW in Horizon Guyot, Necker Ridge, Hawaii, Johnston, Palmyra, Kingman Island from 10/29/1983 to 11/26/1983

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of field activity L-5-83-HW in Horizon Guyot, Necker Ridge, Hawaii, Johnston,...

  1. RCRA Permit for a Hazardous Waste Management Facility, Permit Number NEV HW0101, Annual Summary/Waste Minimization Report

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, Patrick [NSTec

    2014-02-14

    This report summarizes the EPA identification number of each generator from which the Permittee received a waste stream, a description and quantity of each waste stream in tons and cubic feet received at the facility, the method of treatment, storage, and/or disposal for each waste stream, a description of the waste minimization efforts undertaken, a description of the changes in volume and toxicity of waste actually received, any unusual occurrences, and the results of tank integrity assessments. This Annual Summary/Waste Minimization Report is prepared in accordance with Section 2.13.3 of Permit Number NEV HW0101.

  2. Analysis of Secondary Emergency Passive Heat Sink's Ability to Relieve Accident of CPR1000%CPR1000二次侧非能动应急热阱设计与事故缓解能力分析

    Institute of Scientific and Technical Information of China (English)

    王明军; 张亚培; 田文喜; 苏光辉; 秋穗正

    2012-01-01

    The transient thermal hydraulic characteristics of CPR1000 were analyzed using RELAP5/MOD3. 4 to verify the capability of the adopting air-cooled heat exchanger's emergency passive heat sink (EPHS) for accident mitigation under the condition of feed-water line break (FLB). The calculation results show that the EPHS of CPR1000 can supply the water to steam generator immediately and remove the core residual heat after the FLB successfully. Therefore, it demonstrates that the design of the EPHS of CPR1000 is successful.%在主给水管道破裂事故下,利用RELAP5/MOD3.4程序对CPR1000压水堆一回路热工水力参数瞬态特性进行分析计算,验证采用空冷换热器的CPR1000二次侧非能动应急热阱对事故的缓解能力.计算结果表明:CPR1000在发生主给水管道破裂事故后,二次侧非能动应急热阱完全可及时向蒸汽发生器补水,同时导出堆芯余热,保证反应堆处于安全状态,从而验证了CPR1000二次侧非能动应急热阱的设计是成功的.

  3. High growth rate of a-SiC:H films using ethane carbon source by HW-CVD method

    Indian Academy of Sciences (India)

    Mahesh M Kamble; Vaishali S Waman; Sanjay S Ghosh; Azam Mayabadi; Vasant G Sathe; T Shripathi; Habib M Pathan; Sandesh R Jadkar

    2013-12-01

    Hydrogenated amorphous silicon carbide (a-SiC:H) thin films were prepared using pure silane (SiH4) and ethane (C2H6), a novel carbon source, without hydrogen dilution using hot wire chemical vapour deposition (HW-CVD) method at low substrate temperature (200 °C) and at reasonably higher deposition rate (19.5 Å/s < d < 35.2 Å/s). Formation of a-SiC:H films has been confirmed from FTIR, Raman and XPS analysis. Influence of deposition pressure on compositional, structural, optical and electrical properties has been investigated. FTIR spectroscopy analysis revealed that there is decrease in C–H and Si–H bond densities while, Si–C bond density increases with increase in deposition pressure. Total hydrogen content drops from 22.6 to 14.4 at.% when deposition pressure is increased. Raman spectra show increase in structural disorder with increase in deposition pressure. It also confirms the formation of nearly stoichiometric a-SiC:H films. Bandgap calculated using both Tauc’s formulation and absorption at 104 cm-1 shows decreasing trend with increase in deposition pressure. Decrease in refractive index and increase in Urbach energy suggests increase in structural disorder and microvoid density in the films. Finally, it has been concluded that C2H6 can be used as an effective carbon source in HW-CVD method to prepare stoichiometric a-SiC:H films.

  4. Effects of bystander CPR following out-of-hospital cardiac arrest on hospital costs and long-term survival.

    Science.gov (United States)

    Geri, Guillaume; Fahrenbruch, Carol; Meischke, Hendrika; Painter, Ian; White, Lindsay; Rea, Thomas D; Weaver, Marcia R

    2017-06-01

    Bystander cardiopulmonary resuscitation (CPR) is associated with a greater likelihood of survival to hospital discharge after out-of-hospital cardiac arrest (OHCA). However the long-term survival benefits in relationship to cost have not been well-studied. We evaluated bystander CPR, hospital-based costs, and long-term survival following OHCA in order to assess the potential cost-effectiveness of bystander CPR. We conducted a retrospective cohort study of consecutive EMS-treated OHCA patients >=12years who arrested prior to EMS arrival and outside a nursing facility between 2001 and 2010 in greater King County, WA. Utstein-style information was obtained from the EMS registry, including 5-year survival. Costs from the OHCA hospitalization were obtained from the Washington State Comprehensive Hospital Abstract Reporting System. Cost effectiveness was based on hospital costs divided by quality-adjusted life years (QALYs) for a 5-year follow-up window. Of the 4448 eligible patients, 18.5% (n=824) were discharged alive from hospital and 12.1% (n=539) were alive at 5 years. Five-year survival was higher in patients who received bystander CPR (14.3% vs. 8.7%, pbystander CPR. The average (SD) total cost of the initial acute care hospitalization was USD 19,961 (40,498) for all admitted patients and USD 75,175 (52,276) for patients alive at year 5. The incremental cost-effectiveness ratio associated with bystander CPR was USD 48,044 per QALY. Based on this population-based investigation, bystander CPR was positively associated with long-term survival and appears cost-effective. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. The Research of Safety DCS for CPR1000 Nuclear Power Plant%CPR1000核电厂安全级DCS研究

    Institute of Scientific and Technical Information of China (English)

    魏海峰

    2012-01-01

    目前在建CPR1000核电厂(红沿河、宁德、阳江、防城港等)仪控系统采用日本三菱电机和北京广利核联队提供的数字化仪控系统DCS,其中安全级DCS采用日本三菱电机的MLETAC系统,非安全级DCS采用和利时的HOLLAIS-N系统.安全级DCS系统设计遵循单一故障、多样性、独立性、冗余性等原则,本文将对安全级DCS进行介绍.

  6. Functions of standard CPR training on performance qualities of medical volunteers for Mt. Taishan International Mounting Festival.

    Science.gov (United States)

    Fanshan, Meng; Lin, Zhao; Wenqing, Liu; Chunlei, Lu; Yongqiang, Liu; Naiyi, Li

    2013-01-01

    Cardiopulmonary resuscitation (CPR) is a sudden emergency procedure that requires a rapid and efficient response, and personnel training in lifesaving procedures. Regular practice and training are necessary to improve resuscitation skills and reduce anxiety among the staff. As one of the most important skills mastered by medical volunteers serving for Mt. Taishan International Mounting Festival, we randomly selected some of them to evaluate the quality of CPR operation and compared the result with that of the untrained doctors and nurses. In order to evaluate the functions of repeating standard CPR training on performance qualities of medical volunteers for Mt. Taishan International Mounting Festival, their performance qualities of CPR were compared with those of the untrained medical workers working in emergency departments of hospitals in Taian. The CPR performance qualities of 52 medical volunteers (Standard Training Group), who had continually taken part in standard CPR technical training for six months, were tested at random and were compared with those of 68 medical workers (Compared Group) working in emergency departments of hospitals in Taian who hadn't attended CPR training within a year. The QCPR 3535 monitor (provided by Philips Company) was used to measure the standard degree of single simulated CPR performance, including the chest compression depth, frequency, released pressure between compressions and performance time of compression and ventilation, the results of which were recorded in the table and the number of practical compression per minute was calculated. The data were analyzed by x2 Test and t Test. The factors which would influence CPR performance, including gender, age, placement, hand skill, posture of compression and frequency of training, were classified and given parameters, and were put to Logistic repression analysis. The CPR performance qualities of volunteers were much higher than those of the compared group. The overall pass rates

  7. CPR in medical schools: learning by teaching BLS to sudden cardiac death survivors – a promising strategy for medical students?

    Directory of Open Access Journals (Sweden)

    Herkner Harald

    2006-04-01

    Full Text Available Abstract Background Cardiopulmonary resuscitation (CPR training is gaining more importance for medical students. There were many attempts to improve the basic life support (BLS skills in medical students, some being rather successful, some less. We developed a new problem based learning curriculum, where students had to teach CPR to cardiac arrest survivors in order to improve the knowledge about life support skills of trainers and trainees. Methods Medical students who enrolled in our curriculum had to pass a 2 semester problem based learning session about the principles of cardiac arrest, CPR, BLS and defibrillation (CPR-D. Then the students taught cardiac arrest survivors who were randomly chosen out of a cardiac arrest database of our emergency department. Both, the student and the Sudden Cardiac Death (SCD survivor were asked about their skills and knowledge via questionnaires immediately after the course. The questionnaires were then used to evaluate if this new teaching strategy is useful for learning CPR via a problem-based-learning course. The survey was grouped into three categories, namely "Use of AED", "CPR-D" and "Training". In addition, there was space for free answers where the participants could state their opinion in their own words, which provided some useful hints for upcoming programs. Results This new learning-by-teaching strategy was highly accepted by all participants, the students and the SCD survivors. Most SCD survivors would use their skills in case one of their relatives goes into cardiac arrest (96%. Furthermore, 86% of the trainees were able to deal with failures and/or disturbances by themselves. On the trainer's side, 96% of the students felt to be well prepared for the course and were considered to be competent by 96% of their trainees. Conclusion We could prove that learning by teaching CPR is possible and is highly accepted by the students. By offering a compelling appreciation of what CPR can achieve in using

  8. The impact of response time reliability on CPR incidence and resuscitation success: a benchmark study from the German Resuscitation Registry

    Science.gov (United States)

    2011-01-01

    Introduction Sudden cardiac arrest is one of the most frequent causes of death in the world. In highly qualified emergency medical service (EMS) systems, including well-trained emergency physicians, spontaneous circulation may be restored in up to 53% of patients at least until admission to hospital. Compared with these highly qualified EMS systems, markedly lower success rates are observed in other systems. These data clearly show that there are considerable differences between EMS systems concerning treatment success following cardiac arrest and resuscitation, although in all systems international guidelines for resuscitation are used. In this study, we investigated the impact of response time reliability (RTR) on cardiopulmonary resuscitation (CPR) incidence and resuscitation success by using the return of spontaneous circulation (ROSC) after cardiac arrest (RACA) scores and data from seven German EMS systems participating in the German Resuscitation Registry. Methods Anonymised patient data after out-of-hospital cardiac arrest gathered from seven EMS systems in Germany from 2006 to 2009 were analysed with regard to socioeconomic factors (population, area and EMS unit-hours), process quality (RTR, CPR incidence, special CPR measures and prehospital cooling), patient factors (age, gender, cause of cardiac arrest and bystander CPR). End points were defined as ROSC, admission to hospital, 24-hour survival and hospital discharge rate. χ2 tests, odds ratios and the Bonferroni correction were used for statistical analyses. Results Our present study comprised 2,330 prehospital CPR patients at seven centres. The incidence of sudden cardiac arrest ranged from 36.0 to 65.1/100,000 inhabitants/year. We identified two EMS systems (RTR 70%) reached patients within 8 minutes of the call to the dispatch centre 70.4% up to 95.5% of the time. EMS systems arriving relatively later at the patients side (RTR CPR less frequently and admit fewer patients alive to hospital

  9. Adaptive hepatic and intestinal alterations in mice after deletion of NADPH-cytochrome P450 Oxidoreductase (Cpr) in hepatocytes.

    Science.gov (United States)

    Cheng, Xingguo; Gu, Jun; Klaassen, Curtis D

    2014-11-01

    Cytochrome P450 enzymes (P450) play an important role in first-pass metabolism in both the intestine and liver. NADPH-cytochrome P450 oxidoreductase (Cpr) is an essential electron transfer protein required for microsomal P450 activity. Mice with conditional knockout of Cpr in hepatocytes develop normally and survive even with complete loss of liver microsomal P450 activity. Our current studies were performed to determine whether alternative drug-metabolizing pathways increase in an attempt to maintain whole-body homeostasis. In addition to the liver, Cpr is mainly expressed in tissues such as lung, kidney, and gastrointestinal tract. In livers of H-Cpr-null mice, there is a marked increase in mRNA expression of phase I enzymes (Aldh1a1, 1a7, 3a2; Ces1b2, 2a6, and 2a12), antioxidant enzymes (Ho-1, Nqo1, and epoxide hydrolase), phase II enzymes (Ugt1a9; Gsta1/2, m3, m4, m6, t1, and t3; and Sult1a1 and 1d1), and drug transporters (Oatp1a4, Oct3, Mate1, Mdr1a, and Mrp3 and 4). In addition, glucuronide-conjugated bilirubin concentrations are doubled in serum of H-Cpr-null mice. Both constitutive androstane receptor (CAR) and nuclear factor erythroid 2-related factor 2 (Nrf2) protein in nuclei are higher in the livers of H-Cpr-null mice, indicating that CAR and Nrf2 are activated. In the small intestine of H-Cpr-null mice, mRNA expression of Cyp3a11 and Mdr1a, two genes critical for intestinal first-pass metabolism, are markedly up-regulated. In addition, nutrient (Pept1) and cholesterol (Npc1l1) transporters are induced in the small intestine of H-Cpr-null mice. In conclusion, in H-Cpr-null mice, adaptive regulation of alternative detoxification genes in liver and small intestine appear to partially compensate for the loss of microsomal P450 function in liver.

  10. [Ventilation during cardiopulmonary resuscitation (CPR). A literature study and analysis of ventilation strategies].

    Science.gov (United States)

    Wenzel, V; Lindner, K H; Prengel, A W

    1997-02-01

    In a recently published German multicenter study, 25% of the patients with witnessed cardiac arrest outside the hospital were resuscitated successfully and discharged from the hospital. Approximately 100,000 people suffer a fatal cardiac arrest in Germany annually, which is approximately tenfold the number of deaths from motor vehicle accidents. Cardiopulmonary resuscitation (CPR) performed by bystanders is an important part of the chain of survival to minimize the time interval without artificial circulation and ventilation in a cardiac arrest victim. This is especially important in areas with long response times of the emergency medical service (EMS). Early examples of ventilation have been described throughout history. References to mouth-to-mouth ventilation (MTMV) are found in the Bible, in a description of the resuscitation of a coal miner in 1744, and in an experiment in 1796 demonstrating that exhaled gas was safe for breathing. In 1954, Elam and colleagues described artificial respiration with the exhaled gas of a rescuer using a mouth-to-mask ventilation method. The modern CPR era started with the combination of MTMV and chest compressions 35 years ago. However, the value of MTMV is currently under discussion because of a widespread fear of transmission of infectious diseases. Healthcare professionals have stated in several studies that they may withhold MTMV when confronted with a cardiac arrest in a stranger. Although an infection with Mycobacterium tuberculosis is more likely than one with HIV via MTMV, the fear of the public is understandable. An expert committee of the American Heart Association stated that MTMV may be omitted in the initial phase of cardiac arrest, and considered recommending chest compressions only if the EMS will arrive rapidly. In paralyzed volunteers, however, ventilation induced by chest compressions was not able to provide sufficient gas exchange, especially when the airway was not protected. Laboratory investigations studying

  11. Outcome of Prolonged Ventricular Fibrillation and CPR in a Rat Model of Chronic Ischemic Left Ventricular Dysfunction

    Directory of Open Access Journals (Sweden)

    Xiangshao Fang

    2013-01-01

    Full Text Available Patients with chronic left ventricular (LV dysfunction are assumed to have a lower chance of successful CPR and lower likelihood of ultimate survival. However, these assumptions have rarely been documented. Therefore, we investigated the outcome of prolonged ventricular fibrillation (VF and CPR in a rat model of chronic LV dysfunction. Sprague-Dawley rats were randomized to (1 chronic LV dysfunction: animals underwent left coronary artery ligation; and (2 sham control. Echocardiography was used to measure cardiac performance before surgery and 4 weeks after surgery. Four weeks after surgical intervention, 8 min of VF was induced and defibrillation was delivered after 8 min of CPR. LV dilation and low ejection fraction were observed 4 weeks after coronary ligation. With optimal chest compressions, coronary perfusion pressure values during CPR were well maintained and indistinguishable between groups. There were no differences in resuscitability and numbers of shock required for successful resuscitation between groups. Despite the significantly decreased cardiac index in LV dysfunction animals before induction of VF, no differences in cardiac index were observed between groups following resuscitation, which was associated with the insignificant difference in postresuscitation survival. In conclusion, the outcomes of CPR were not compromised by the preexisting chronic LV dysfunction.

  12. CPR1: a gene encoding a putative signal peptidase that functions in pathogenicity of Colletotrichum graminicola to maize.

    Science.gov (United States)

    Thon, M R; Nuckles, E M; Takach, J E; Vaillancourt, L J

    2002-02-01

    Colletotrichum graminicola causes anthracnose leaf blight and stalk rot of maize. We used restriction-enzyme mediated insertional (REMI) mutagenesis to identify a gene in this fungus that is required for pathogenicity to both stalks and leaves. The predicted polypeptide encoded by this gene, which we have named CPR1, is similar to a family of proteins that comprise one subunit of the eukaryotic microsomal signal peptidase. The nonpathogenic CPR1 REMI mutant contains a plasmid integration in the 3' untranslated region of the gene, 19 bp downstream from the stop codon. The result is a significant reduction in transcript levels in comparison to the wild type, perhaps as a result of increased transcript instability. We were unable to knock out the CPR1 gene, and it may be essential for viability. Microscopic examination of the REMI mutant on maize leaves revealed that it is fully capable of penetrating and colonizing host cells during the initial, biotrophic phases of the disease interaction but, unlike the wild type, it appears to be unable to switch to a necrotrophic mode of growth. We suggest that the CPR1 REMI mutant may be unable to secrete sufficient quantities of degradative enzymes to support that transition. The CPR1 REMI mutant provides us with a useful tool for future studies of the role of fungal protein transport in this important stalk rot disease of maize.

  13. CPR1000主控室可居留性设计改进

    Institute of Scientific and Technical Information of China (English)

    赵海; 刘晓爽

    2010-01-01

    文章参照RG1.196及NUREG—0800对主控室可居留性的要求,通过对CPR1000主控室可居留性系统的分析研究,针对其可居留区域范围过大、微正压无法平稳维持、应急通风系统不独立等问题,提出改进方案,确保在事故工况下主控室的可居留性。

  14. Evolution of Circular Polarization Ratio (CPR) Profiles of Kilometer-scale Craters on the Lunar Maria

    Science.gov (United States)

    King, I. R.; Fassett, C. I.; Thomson, B. J.; Minton, D. A.; Watters, W. A.

    2017-01-01

    When sufficiently large impact craters form on the Moon, rocks and unweathered materials are excavated from beneath the regolith and deposited into their blocky ejecta. This enhances the rockiness and roughness of the proximal ejecta surrounding fresh impact craters. The interior of fresh craters are typically also rough, due to blocks, breccia, and impact melt. Thus, both the interior and proximal ejecta of fresh craters are usually radar bright and have high circular polarization ratios (CPR). Beyond the proximal ejecta, radar-dark halos are observed around some fresh craters, suggesting that distal ejecta is finer-grained than background regolith. The radar signatures of craters fade with time as the regolith grows.

  15. Preliminary assessment of a combined passive safety system for typical 3-loop PWR CPR1000

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Zijiang; Shan, Jianqiang, E-mail: jqshan@mail.xjtu.edu.cn; Gou, Junli

    2017-03-15

    Highlights: • A combined passive safety system was placed on a typical 3-loop PWR CPR1000. • Three accident analyses show the three different accident mitigation methods of the passive safety system. • The three mitigation methods were proved to be useful. - Abstract: As the development of the nuclear industry, passive technology turns out to be a remarkable characteristic of advanced nuclear power plants. Since the 20th century, much effort has been given to the passive technology, and a number of evolutionary passive systems have developed. Thoughts have been given to upgrade the existing reactors with passive systems to meet stricter safety demands. In this paper, the CPR1000 plant, which is one kind of mature pressurized water reactor plants in China, is improved with some passive systems to enhance safety. The passive systems selected are as follows: (1) the reactor makeup tank (RMT); (2) the advanced accumulator (A-ACC); (3) the in-containment refueling water storage tank (IRWST); (4) the passive emergency feed water system (PEFS), which is installed on the secondary side of SGs; (5) the passive depressurization system (PDS). Although these passive components is based on the passive technology of some advanced reactors, their structural and trip designs are adjusted specifically so that it could be able to mitigate accidents of the CPR1000. Utilizing the RELAP5/MOD3.3 code, accident analyses (small break loss of coolant accident, large break loss of coolant accident, main feed water line break accident) of this improved CPR1000 plant were presented to demonstrate three different accident mitigation methods of the safety system and to test whether the passive safety system preformed its function well. In the SBLOCA, all components of the passive safety system were put into work sequentially, which prevented the core uncover. The LBLOCA analysis illustrates the contribution of the A-ACCs whose small-flow-rate injection can control the maximum cladding

  16. Increasing first responder CPR during resuscitation of out-of-hospital cardiac arrest using automated external defibrillators.

    Science.gov (United States)

    Shah, Sachita; Garcia, Michele; Rea, Thomas D

    2006-10-01

    Evidence supports that increasing the balance of "hands-on" CPR may improve survival in ventricular fibrillation out-of-hospital cardiac arrest (OHCA). We assessed whether training and/or AED reconfiguration was associated with an increase in the proportion of time during which CPR was performed between first and second stacks of shocks. The investigation was a cohort study of 291 persons who suffered ventricular fibrillation OHCA and were treated with at least two stacks of AED shocks by emergency medical services (EMS) first-tier responders. In January 2003, first-tier providers were retrained regarding the importance of CPR. In addition, a subset of AEDs was reconfigured to remove continuous fibrillation detection and its associated voice prompts as to be comparable with other AED models. The amount of time spent on CPR was assessed through review of AED electronic and audio recordings to compare the pre-intervention (n = 241) and post-intervention periods (n = 50). The proportion of time spent performing hands-on CPR between first and second stacks of shocks was 0.40 in the pre-intervention period compared to 0.51 in the post-intervention period (p = 0.001). The difference was greatest for AEDs where EMS was retrained and the AED reconfigured (0.33 versus 0.50, p = 0.01). No difference in survival was detected between the pre- and post-intervention periods (24.9% versus 28.0%, p = 0.65). An intervention consisting of retraining and AED reconfiguration was associated with an increase in the proportion of time spent performing CPR between first and second stacks of shocks by first-tier EMS. Whether this increase improves patient outcomes requires additional study.

  17. HELIX: A Versatile SW Composition Instrument

    Science.gov (United States)

    Sheldon, R.; Gallagher, D.; Adrian, M. L.

    2001-12-01

    Composition instruments have made themselves indispensable in the study of heliospheric plasmas, since only they are able to identify particle ``tracers" that reveal secrets of plasma origin and transport. However, future mission opportunities are likely to put severe constraints on present instrument designs, requiring a radical rethinking of mass spectrometry techniques. Time-of-flight methods currently give the highest mass resolution for the solar wind, but at the cost of limited dynamic range. Likewise magnetic deflection and quadrupole techniques have limitations that preclude their use for heliospheric studies. We present a novel SW mass spectrometer design that is capable of a breakthrough mass resolution M/Δ M>3000, in a 1 liter, 1 kg package with a huge geometric factor of 0.03cm2sr. Such capabilities enable new heliospheric science, such as the molecular identification of cometary or LISM constituents, the plasma composition of magnetic holes, or the triple isotopes of oxygen. Scaling this design down to more typical SW composition instrument abilities, we can achieve a mass resolution of M/Δ M=100 with a 5x10-4cm2sr in a 5 cm package weighing less than 100 grams. Such a miniature detector would be ideal for multiple space probes or a Pluto flyby. We will present the first preliminary data from a modulated ion beam demonstrating the mass resolution capabilities of this breakthrough design as well as some of the challenges in the implementation.

  18. Cardiopulmonary resuscitation (CPR) plus delayed defibrillation versus immediate defibrillation for out-of-hospital cardiac arrest.

    Science.gov (United States)

    Huang, Yu; He, Qing; Yang, Li J; Liu, Guan J; Jones, Alexander

    2014-09-12

    Sudden cardiac arrest (SCA) is a common health problem associated with high levels of mortality. Cardiac arrest is caused by three groups of dysrhythmias: ventricular fibrillation (VF) or pulseless ventricular tachycardia (VT), pulseless electric activity (PEA) and asystole. The most common dysrhythmia found in out-of-hospital cardiac arrest (OHCA) is VF. During VF or VT, cardiopulmonary resuscitation (CPR) provides perfusion and oxygenation to the tissues, whilst defibrillation restores a viable cardiac rhythm. Early successful defibrillation is known to improve outcomes in VF/VT. However, it has been hypothesized that a period of CPR before defibrillation creates a more conducive physiological environment, increasing the likelihood of successful defibrillation. The order of priority of CPR versus defibrillation therefore remains in contention. As previous studies have remained inconclusive, we conducted a systematic review of available evidence in an attempt to draw conclusions on whether CPR plus delayed defibrillation or immediate defibrillation resulted in better outcomes in OHCA. To examine whether an initial one and one-half to three minutes of CPR administered by paramedics before defibrillation versus immediate defibrillation on arrival influenced survival rates, neurological outcomes or rates of return of spontaneous circulation (ROSC) in OHCA. We searched the following databases: the Cochrane Central Register of Controlled trials (CENTRAL) (2013, Issue 6); MEDLINE (Ovid) (1948 to May 2013); EMBASE (1980 to May 2013); the Institute for Scientific Information (ISI) Web of Science (1980 to May 2013) and the China Academic Journal Network Publishing Database (China National Knowledge Infrastructure (CNKI), 1980 to May 2013). We included studies published in all languages. We also searched the Current Controlled Trials and Clinical Trials databases for ongoing trials. We screened the references lists of studies included in our review against the reference

  19. Emergency nurses' current practices and understanding of family presence during CPR.

    LENUS (Irish Health Repository)

    Madden, Eilis

    2012-02-03

    PURPOSE: To examine emergency nurses\\' current practices and understanding of family presence during CPR in the emergency department, Cork University Hospital, Republic of Ireland. METHOD: A quantitative descriptive design was used in the study. A questionnaire developed by ENA was distributed to emergency nurses working in a level I trauma emergency department at Cork University Hospital. The total sample number was 90, including all emergency nurses with at least 6 months\\' emergency nursing experience. RESULTS: Emergency nurses often took families to the bedside during resuscitation efforts (58.9%) or would do so if the opportunity arose (17.8%). A high percentage (74.4%) of respondents would prefer a written policy allowing the option of family presence during CPR. The most significant barrier to family witnessed resuscitation (FWR) was conflicts occurring within the emergency team. The most significant facilitator to FWR was a greater understanding of health care professionals on the benefits of FWR to patients and families, indicating the need for educational development. CONCLUSION: The findings of the study and previously published studies indicate the need for development of written polices and guidelines on the practice to meet the needs of patients, families, and staff by providing consistent, safe, and caring practices for all involved in the resuscitation process. Recommendations of the study include the development of a written policy and an educational programme on the safe implementation and practices of FWR.

  20. Importance of basic CPR techniques. A study in the Region of Murcia

    Directory of Open Access Journals (Sweden)

    J. Arturo Abraldes Valeiras

    2011-01-01

    Full Text Available Annually in Spain many people die from diseases related to heart. Heart attack is the main cause of such deaths. Know and control the basic techniques of basic Cardiopulmonary resuscitation (CPR are essential to help a person away from these features. This study examined 1 the importance of knowing these techniques in the general population, and 2 the perception of the difficulty of understanding and application of techniques. We used a questionnaire designed "ad hoc" as a tool for collecting information. The instrument was subjected to validation and reliability for the study. The questionnaire was completed by 235 volunteers aged between 10 and 65. We performed a descriptive analysis, based on gender and the variables importance of knowledge and learning / apply techniques. Among the most relevant results, we emphasize an interest of society to improve training in this type of knowledge. Training would be ideal in most age groups of people (teens to seniors. Likewise, CPR techniques are easy to understand and execute a lesser extent, relevant perception among people who acknowledge and application these techniques

  1. Comparative palynological analysis of Lygodium venustum Sw. and L. volubile Sw. (Lygodiaceae

    Directory of Open Access Journals (Sweden)

    JUAN P. RAMOS GIACOSA

    2013-06-01

    Full Text Available The genus Lygodium Sw. is one of the few climbing ferns in the world. The spores of L. venustum Sw. and L. volubile Sw. were studied using light, scanning, and transmission electron microscopy. This work is based on herbarium material. The spores are trilete, triangular, with straight to convex sides in polar view. The equatorial diameter is 72-104 µm, and the polar diameter is 64-84 µm. The ornamentation in L. venustum is verrucate-tuberculate while in L. volubile, it is verrucate-tuberculate in the proximal face but with a few ridges on the distal face, where a micro-ornamentation constituted by verrrucae and tubercles is observed. An equatorial ridge is also present. The exospore is two-layered; in L. venustum, it is smooth in contrast with the ornamented exospore of L. volubile. The perispore of the two species analyzed is similar. This wall is four-layered with particular elements arranged radially in the middle layer. On the spores surface of both species, few spheroids are observed. The results introduced in the current study may be useful for the systematics of the genus as well as for phylogenetic purposes.O gênero Lygodium Sw. é um das poucas samambaias trepadoras no mundo. Os esporos de L. venustum Sw. e L. volubile Sw. foi estudados com microscopias de luz e eletrônicas de transmissão e varredura. Este trabalho é baseado em material de herbário. Os esporos são trilete, triangular com lados retos para convexo em vista polar. O equatorial diâmetro é 72-104 µm e o diâmetro polar é 64-84 µm. O ornamentação em L. venustum é verrucose-tuberculoso enquanto em L. volubile é verrucose-tuberculoso no proximal cara e com poucos cume no distal cara, em que um micro-ornamentação constituída por verrugas e tubérculos é observado. Um cume equatorial também está presente. O exosporo é de dois camadas, em L. venustum é liso em contraste com o exosporo ornamentado de L. volubile. O perisporo é similar nas duas esp

  2. Effect of bystander CPR initiation prior to the emergency call on ROSC and 30day survival-An evaluation of 548 emergency calls.

    Science.gov (United States)

    Viereck, Søren; Palsgaard Møller, Thea; Kjær Ersbøll, Annette; Folke, Fredrik; Lippert, Freddy

    2017-02-01

    This study aimed at evaluating if time for initiation of bystander cardiopulmonary resuscitation (CPR) - prior to the emergency call (CPRprior) versus during the emergency call following dispatcher-assisted CPR (CPRduring) - was associated with return of spontaneous circulation (ROSC) and 30-day survival. The secondary aim was to identify predictors of CPRprior. This observational study evaluated out-of-hospital cardiac arrests (OHCA) occurring in the Capital Region of Denmark from 01.01.2013 to 31.12.2013. OHCAs were linked to emergency medical dispatch centre records and corresponding emergency calls were evaluated. Multivariable logistic regression analyses were applied to evaluate the association between time for initiation of bystander CPR, ROSC, and 30-day survival. Univariable logistic regression analyses were applied to identify predictors of CPRprior. The study included 548 emergency calls for OHCA patients receiving bystander CPR, 34.9% (n=191) in the CPRprior group and 65.1% (n=357) in the CPRduring group. Multivariable analyses showed no difference in ROSC (OR=0.88, 95% CI: 0.56-1.38) or 30-day survival (OR=1.14, 95% CI: 0.68-1.92) between CPRprior and CPRduring. Predictors positively associated with CPRprior included witnessed OHCA and healthcare professional bystanders. Predictors negatively associated with CPRprior included residential location, solitary bystanders, and bystanders related to the patient. The majority of bystander CPR (65%) was initiated during the emergency call, following dispatcher-assisted CPR instructions. Whether bystander CPR was initiated prior to emergency call versus during the emergency call following dispatcher-assisted CPR was not associated with ROSC or 30-day survival. Dispatcher-assisted CPR was especially beneficial for the initiation of bystander CPR in residential areas. Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  3. PRLs Promote Spreading, Adhesion, and Proliferation of Human SW480 and SW620 Cells

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Recent studies suggest that PRL-3 is involved in the metastasis of colorectal cancer, but the mechanism concerning that has not been well defined. This article expresses PRL-1, PRL-2, and PRL-3 and the catalytically inactive mutant forms of those enzymes in SW620 and SW480 cells, two human cell lines derived from non-metastatic cancer and metastatic colorectal cancer, respectively. While the expression of the native forms of PRLs promotes the spreading, adhesion, and proliferation of these cells, the expression of their mutant forms inhibits the earlier-mentioned processes. These data thus provide a cellular mechanism for the role of PRL-3 in tumor metastasis and suggest that all the three PRLs have similar functions.

  4. Planktonic foraminiferal biogeography in the Indian sector of the Southern Ocean: Contribution from CPR data

    Science.gov (United States)

    Meilland, Julie; Fabri-Ruiz, Salomé; Koubbi, Philippe; Monaco, Claire Lo; Cotte, Cédric; Hosie, Graham W.; Sanchez, Sophie; Howa, Hélène

    2016-04-01

    Within the framework of the Scientific Committee on Antarctic Research (SCAR) Southern Ocean-Continuous Plankton Recorder (SO-CPR) Survey, the oceanic regions around Crozet and Kerguelen Islands were investigated in February-March 2013. Living planktonic Foraminifera (LPF) were collected in the upper mixed layer with a CPR along a 2160 nautical mile sea transect that crossed main hydrological fronts in the Indian sector of the Southern Ocean. In the SO-CPR database, mean total abundances of Foraminifera occurring during late austral summer are highly variable at an inter-annual scale, from 10 to 250 ind.m-3, representing 10-40% of the total zooplankton abundance, respectively. In the Southern Ocean, major inter-annual changes in zooplankton community structure were already reported. In this study, we describe the large scale distributional pattern of individual planktonic foraminiferal species living in near-surface waters of the Indian sector of the Southern Ocean, and we attempt to explain why major spatial variability in relative species abundances occurs during a late austral summer. In February-March 2013, LPF total abundances recorded between 42.86°S and 56.42°S ranged from 0 to a maximum of 258 ind.m-3. In the Open Ocean Zone, the LPF community was composed of four major species (Globigerinita uvula, Neogloboquadrina pachyderma, Neogloboquadrina incompta, Globigerina bulloides). Generally, LPF total abundances are supposed to mirror primary production induced by hydrological fronts or induced by topography near Crozet and Kerguelen Islands. However, during late austral summer 2013, high foraminiferal abundances in the upper mixed layer did not always match the pattern of near-surface primary production (high Chl-a concentration areas delineated from satellite imagery). Low LPF standing stocks in late austral summer in the Southern Ocean contrasted with the presence of high densities of heavily silicified diatoms. This suggests that the late bloom

  5. The Campylobacter jejuni CprRS two-component regulatory system regulates aspects of the cell envelope

    Science.gov (United States)

    As a leading cause of foodborne bacterial gastroenteritis, Campylobacter jejuni is a significant human pathogen. C. jejuni lives commensally in the gastrointestinal tract of animals, but tolerates variable environments during transit to a susceptible host. A two-component regulatory system, CprRS, w...

  6. Conditions and procedures for in-hospital extracorporeal life support (ECLS) in cardiopulmonary resuscitation (CPR) of adult patients.

    Science.gov (United States)

    Swol, Justyna; Belohlávek, Jan; Haft, Jonathan W; Ichiba, Shingo; Lorusso, Roberto; Peek, Giles J

    2016-04-01

    The use of extracorporeal life support (ECLS) in cardiopulmonary resuscitation (CPR; ECPR) has been repeatedly published as non-randomized studies, mainly case series and case reports. The aim of this article is to support physicians, perfusionists, nurses and extracorporeal membrane oxygenation (ECMO) specialists who regularly perform ECPR or are willing to start an ECPR program by establishing standards for safe and efficient ECPR procedures. This article represents the experience and recommendations of physicians who provide ECPR routinely. Based on its survival and outcome rates, ECPR can be considered when determining the optimal treatment of patients who require CPR. The successful performance of ECLS cannulation during CPR is a life-saving measure and has been associated with improved outcome (including neurological outcome) after CPR. We summarize the general structure of an ECLS team and describe the cannulation procedure and the approaches for post-resuscitation care. The differences in hospital organizations and their regulations may result in variations of this model. © The Author(s) 2015.

  7. A Comparison of Internet-Based Learning and Traditional Classroom Lecture to Learn CPR for Continuing Medical Education

    Science.gov (United States)

    Hemmati, Nima; Omrani, Soghra; Hemmati, Naser

    2013-01-01

    The purpose of this study was to compare the satisfaction and effectiveness of Internet-based learning (IBL) and traditional classroom lecture (TCL) for continuing medical education (CME) programs by comparing final resuscitation exam results of physicians who received the newest cardiopulmonary resuscitation (CPR) curriculum guidelines training…

  8. Arabidopsis CPR5 is a senescence-regulatory gene with pleiotropic functions as predicted by the evolutionary theory of senescence

    NARCIS (Netherlands)

    Jing, Hai-Chun; Anderson, Lisa; Sturre, Marcel J. G.; Hille, Jacques; Dijkwel, Paul P.

    2007-01-01

    Arabidopsis CPR5 is a senescence-regulatory gene with pleiotropic functions as predicted by the evolutionary theory of senescence Hai-Chun Jing1,2, Lisa Anderson3, Marcel J.G. Sturre1, Jacques Hille1 and Paul P. Dijkwel1,* 1Molecular Biology of Plants, Groningen Biomolecular Sciences and Biotechnolo

  9. Arabidopsis CPR5 is a senescence-regulatory gene with pleiotropic functions as predicted by the evolutionary theory of senescence

    NARCIS (Netherlands)

    Jing, Hai-Chun; Anderson, Lisa; Sturre, Marcel J. G.; Hille, Jacques; Dijkwel, Paul P.

    2007-01-01

    Arabidopsis CPR5 is a senescence-regulatory gene with pleiotropic functions as predicted by the evolutionary theory of senescence Hai-Chun Jing1,2, Lisa Anderson3, Marcel J.G. Sturre1, Jacques Hille1 and Paul P. Dijkwel1,* 1Molecular Biology of Plants, Groningen Biomolecular Sciences and

  10. Introducing systematic dispatcher-assisted cardiopulmonary resuscitation (telephone-CPR) in a non-Advanced Medical Priority Dispatch System (AMPDS): implementation process and costs.

    Science.gov (United States)

    Dami, Fabrice; Fuchs, Vincent; Praz, Laurent; Vader, John-Paul

    2010-07-01

    In order to improve the quality of our Emergency Medical Services (EMS), to raise bystander cardiopulmonary resuscitation rates and thereby meet what is becoming a universal standard in terms of quality of emergency services, we decided to implement systematic dispatcher-assisted or telephone-CPR (T-CPR) in our medical dispatch center, a non-Advanced Medical Priority Dispatch System. The aim of this article is to describe the implementation process, costs and results following the introduction of this new "quality" procedure. This was a prospective study. Over an 8-week period, our EMS dispatchers were given new procedures to provide T-CPR. We then collected data on all non-traumatic cardiac arrests within our state (Vaud, Switzerland) for the following 12 months. For each event, the dispatchers had to record in writing the reason they either ruled out cardiac arrest (CA) or did not propose T-CPR in the event they did suspect CA. All emergency call recordings were reviewed by the medical director of the EMS. The analysis of the recordings and the dispatchers' written explanations were then compared. During the 12-month study period, a total of 497 patients (both adults and children) were identified as having a non-traumatic cardiac arrest. Out of this total, 203 cases were excluded and 294 cases were eligible for T-CPR. Out of these eligible cases, dispatchers proposed T-CPR on 202 occasions (or 69% of eligible cases). They also erroneously proposed T-CPR on 17 occasions when a CA was wrongly identified (false positive). This represents 7.8% of all T-CPR. No costs were incurred to implement our study protocol and procedures. This study demonstrates it is possible, using a brief campaign of sensitization but without any specific training, to implement systematic dispatcher-assisted cardiopulmonary resuscitation in a non-Advanced Medical Priority Dispatch System such as our EMS that had no prior experience with systematic T-CPR. The results in terms of T-CPR delivery

  11. A survey of attitudes and factors associated with successful cardiopulmonary resuscitation (CPR knowledge transfer in an older population most likely to witness cardiac arrest: design and methodology

    Directory of Open Access Journals (Sweden)

    Brehaut Jamie C

    2008-11-01

    Full Text Available Abstract Background Overall survival rates for out-of-hospital cardiac arrest rarely exceed 5%. While bystander cardiopulmonary resuscitation (CPR can increase survival for cardiac arrest victims by up to four times, bystander CPR rates remain low in Canada (15%. Most cardiac arrest victims are men in their sixties, they usually collapse in their own home (85% and the event is witnessed 50% of the time. These statistics would appear to support a strategy of targeted CPR training for an older population that is most likely to witness a cardiac arrest event. However, interest in CPR training appears to decrease with advancing age. Behaviour surrounding CPR training and performance has never been studied using well validated behavioural theories. Methods/Design The overall goal of this study is to conduct a survey to better understand the behavioural factors influencing CPR training and performance in men and women 55 years of age and older. The study will proceed in three phases. In phase one, semi-structured qualitative interviews will be conducted and recorded to identify common categories and themes regarding seeking CPR training and providing CPR to a cardiac arrest victim. The themes identified in the first phase will be used in phase two to develop, pilot-test, and refine a survey instrument based upon the Theory of Planned Behaviour. In the third phase of the project, the final survey will be administered to a sample of the study population over the telephone. Analyses will include measures of sampling bias, reliability of the measures, construct validity, as well as multiple regression analyses to identify constructs and beliefs most salient to seniors' decisions about whether to attend CPR classes or perform CPR on a cardiac arrest victim. Discussion The results of this survey will provide valuable insight into factors influencing the interest in CPR training and performance among a targeted group of individuals most susceptible to

  12. Evaluation of pediatric CPR course on knowledge of pediatric residents--before and after ACLS course.

    Science.gov (United States)

    Soltani, Alireza Ebrahim; Khan, Zahid Hussain; Arbabi, Shahriar; Hossini, Babak; Nahvi, Hedaiatollah; Agamohammadi, Asghar

    2009-02-01

    An evaluation was conducted on the knowledge gained by pediatric residents on CPR, before and after a PALS (Pediatric Advanced Cardiac Life Support) course. Following an examination of all pediatric residents at Tehran University of Medical Sciences, they were divided into two groups: non-trained (Group 1) and a group scheduled to undergone training (Group 2). A course on ACLS was conducted. Examination were performed before and after the ACLS course. The mean of the examination prior to the course in Group 1 and 2 was low, reflecting no significant differences between the Groups. Examination after the ACLS course showed a statistically significant improvement in Group 2 (P ACLS course and enhanced after the course.

  13. Extracorporeal Cardiopulmonary Resuscitation (E-CPR) During Pediatric In-Hospital Cardiopulmonary Arrest Is Associated With Improved Survival to Discharge: A Report from the American Heart Association's Get With The Guidelines-Resuscitation (GWTG-R) Registry.

    Science.gov (United States)

    Lasa, Javier J; Rogers, Rachel S; Localio, Russell; Shults, Justine; Raymond, Tia; Gaies, Michael; Thiagarajan, Ravi; Laussen, Peter C; Kilbaugh, Todd; Berg, Robert A; Nadkarni, Vinay; Topjian, Alexis

    2016-01-12

    Although extracorporeal cardiopulmonary resuscitation (E-CPR) can result in survival after failed conventional CPR (C-CPR), no large, systematic comparison of pediatric E-CPR and continued C-CPR has been reported. Consecutive patients CPR events ≥10 minutes in duration reported to the Get With the Guidelines-Resuscitation registry between January 2000 and December 2011 were identified. Hospitals were grouped by teaching status and location. Primary outcome was survival to discharge. Regression modeling was performed, conditioning on hospital groups. A secondary analysis was performed with the use of propensity score matching. Of 3756 evaluable patients, 591 (16%) received E-CPR and 3165 (84%) received C-CPR only. Survival to hospital discharge and survival with favorable neurological outcome (Pediatric Cerebral Performance Category score of 1-3 or unchanged from admission) were greater for E-CPR (40% [237 of 591] and 27% [133 of 496]) versus C-CPR patients (27% [862 of 3165] and 18% [512 of 2840]). Odds ratios (ORs) for survival to hospital discharge and survival with favorable neurological outcome were greater for E-CPR versus C-CPR. After adjustment for covariates, patients receiving E-CPR had higher odds of survival to discharge (OR, 2.80; 95% confidence interval, 2.13-3.69; PCPR. This association persisted when analyzed by propensity score-matched cohorts (OR, 1.70; 95% confidence interval, 1.33-2.18; PCPR of ≥10 minutes duration, E-CPR was associated with improved survival to hospital discharge and survival with favorable neurological outcome compared with C-CPR. © 2015 American Heart Association, Inc.

  14. Molecular population genetics of the NADPH cytochrome P450 reductase (CPR) gene in Anopheles minimus.

    Science.gov (United States)

    Srivastava, Hemlata; Huong, Ngo Thi; Arunyawat, Uraiwan; Das, Aparup

    2014-08-01

    Development of insecticide resistance (IR) in mosquito vectors is a primary huddle to malaria control program. Since IR has genetic basis, and genes constantly evolve with response to environment for adaptation to organisms, it is important to know evolutionary pattern of genes conferring IR in malaria vectors. The mosquito Anopheles minimus is a major malaria vector of the Southeast (SE) Asia and India and is susceptible to all insecticides, and thus of interest to know if natural selection has shaped variations in the gene conferring IR. If not, the DNA fragment of such a gene could be used to infer population structure and demography of this species of malaria vector. We have therefore sequenced a ~569 bp DNA segment of the NADPH cytochrome P450 reductase (CPR) gene (widely known to confer IR) in 123 individuals of An. minimus collected in 10 different locations (eight Indian, one Thai and one Vietnamese). Two Indian population samples were completely mono-morphic in the CPR gene. In general, low genetic diversity was found with no evidence of natural selection in this gene. The data were therefore analyzed to infer population structure and demography of this species. The 10 populations could be genetically differentiated into four different groups; the samples from Thailand and Vietnam contained high nucleotide diversity. All the 10 populations conform to demographic equilibrium model with signature of past population expansion in four populations. The results in general indicate that the An. minimus mosquitoes sampled in the two SE Asian localities contain several genetic characteristics of being parts of the ancestral population.

  15. Updated teaching techniques improve CPR performance measures: a cluster randomized, controlled trial.

    Science.gov (United States)

    Ettl, Florian; Testori, Christoph; Weiser, Christoph; Fleischhackl, Sabine; Mayer-Stickler, Monika; Herkner, Harald; Schreiber, Wolfgang; Fleischhackl, Roman

    2011-06-01

    The first-aid training necessary for obtaining a drivers license in Austria has a regulated and predefined curriculum but has been targeted for the implementation of a new course structure with less theoretical input, repetitive training in cardiopulmonary resuscitation (CPR) and structured presentations using innovative media. The standard and a new course design were compared with a prospective, participant- and observer-blinded, cluster-randomized controlled study. Six months after the initial training, we evaluated the confidence of the 66 participants in their skills, CPR effectiveness parameters and correctness of their actions. The median self-confidence was significantly higher in the interventional group [IG, visual analogue scale (VAS:"0" not-confident at all,"100" highly confident):57] than in the control group (CG, VAS:41). The mean chest compression rate in the IG (98/min) was closer to the recommended 100 bpm than in the CG (110/min). The time to the first chest compression (IG:25s, CG:36s) and time to first defibrillator shock (IG:86s, CG:92s) were significantly shorter in the IG. Furthermore, the IG participants were safer in their handling of the defibrillator and started with countermeasures against developing shock more often. The management of an unconscious person and of heavy bleeding did not show a difference between the two groups even after shortening the lecture time. Motivation and self-confidence as well as skill retention after six months were shown to be dependent on the teaching methods and the time for practical training. Courses may be reorganized and content rescheduled, even within predefined curricula, to improve course outcomes. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  16. Novel 2,4-Dichlorophenoxyacetic Acid Degradation Genes from Oligotrophic Bradyrhizobium sp. Strain HW13 Isolated from a Pristine Environment

    Science.gov (United States)

    Kitagawa, Wataru; Takami, Sachiko; Miyauchi, Keisuke; Masai, Eiji; Kamagata, Yoichi; Tiedje, James M.; Fukuda, Masao

    2002-01-01

    The tfd genes of Ralstonia eutropha JMP134 are the only well-characterized set of genes responsible for 2,4-dichlorophenoxyacetic acid (2,4-D) degradation among 2,4-D-degrading bacteria. A new family of 2,4-D degradation genes, cadRABKC, was cloned and characterized from Bradyrhizobium sp. strain HW13, a strain that was isolated from a buried Hawaiian soil that has never experienced anthropogenic chemicals. The cadR gene was inferred to encode an AraC/XylS type of transcriptional regulator from its deduced amino acid sequence. The cadABC genes were predicted to encode 2,4-D oxygenase subunits from their deduced amino acid sequences that showed 46, 44, and 37% identities with the TftA and TftB subunits of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) oxygenase of Burkholderia cepacia AC1100 and with a putative ferredoxin, ThcC, of Rhodococcus erythropolis NI86/21, respectively. They are thoroughly different from the 2,4-D dioxygenase gene, tfdA, of R. eutropha JMP134. The cadK gene was presumed to encode a 2,4-D transport protein from its deduced amino acid sequence that showed 60% identity with the 2,4-D transporter, TfdK, of strain JMP134. Sinorhizobium meliloti Rm1021 cells containing cadRABKC transformed several phenoxyacetic acids, including 2,4-D and 2,4,5-T, to corresponding phenol derivatives. Frameshift mutations indicated that each of the cadRABC genes was essential for 2,4-D conversion in strain Rm1021 but that cadK was not. Five 2,4-D degraders, including Bradyrhizobium and Sphingomonas strains, were found to have cadA gene homologs, suggesting that these 2,4-D degraders share 2,4-D degradation genes similar to those of strain HW13 cadABC. PMID:11751829

  17. DCS Cabinet Power Loss Analysis for CPR 1000 Nuclear Power Plant%CPR1000核电厂DCS机柜失电分析

    Institute of Scientific and Technical Information of China (English)

    周亮; 赵岩峰; 孙永滨

    2014-01-01

    The DCS overall structure of CRP1000 nuclear power plant was introduced . Based on the RPC ,the signal interface character and signal processing mechanism on the key root were analyzed .By the power loss analyzing of RPC ,the RPC loss power may lead reactor trip signal from anticipated transient without scram (ATWS) system .The results indicate that it is necessary to search DCS cabinet power loss analysis .Optimi‐zing and assigning the main waterflow signals can avoid trigger reactor trip signal by mistake .The DCS cabinet power loss analysis can optimize the I&C (instrumentation and control) design and increase the nuclear plant’s reliability .%介绍了CPR1000核电厂数字化控制系统(DCS)的总体结构,以反应堆保护机柜(RPC)为基础,分析RPC的信号接口特性和信号关键路径节点的信号处理机制。结合RPC Ⅳ保护通道失电造成未能停堆的预期瞬变(ATWS)系统误发停堆信号的原因进行分析及优化,结果表明:对DCS机柜失电分析的研究是必要的,通过对RPC Ⅳ的给水流量信息进行优化和合理分配,可避免误发停堆信号。失电分析可优化仪控的设计,提高核电厂的可靠性。

  18. Comparison between CPR Autopulse (zoll) Type of Instrument and Manual CPR Technique in Implementing Cardiopulmonary Resuscitation%Autopulse(zoll)型心肺复苏仪与人工心肺复苏效果比较

    Institute of Scientific and Technical Information of China (English)

    张玉莲; 张浩

    2011-01-01

    目的 比较使用Autopulse(zoll)型心肺复苏仪和人工心肺复苏的效果以评价Autopulse(zoll)型心肺复苏仪在临床应用的价值.方法 选择122例院内发生心跳呼吸骤停患者随机分为试验组和对照组,试验组使用Autopulse(zoll)型心肺复苏仪,对照组采用人工标准心肺复苏进行心肺复苏.比较两组患者的循环、呼吸恢复情况,复苏成功率及24 h存活率.结果 试验组患者平均动脉压和脉搏氧饱和度水平高于对照组,差异均有统计学意义(P<0.05);试验组自主循环恢复时间明显短于对照组[(6.1±1.8)min和(15.2±2.3)min,P<0.05];试验组复苏成功率高于对照组(70.8%和33.3%,P<0.01);试验组24 h存活率高于对照组,差异有统计学意义(35.4%和23.6%,P<0.05).结论 Autopulse(zoll)型心肺复苏仪在循环、呼吸恢复情况,复苏成功率及24 h存活率方面优于人工心肺复苏.%Objective Compare the use of Autopulse ( zoll ) type of cardiopulmonary resuscitation instrument with the manual standard CPR technique to evaluate the clinical effectiveness of Autopulse ( zoll) type CPR device. Methods 122 cardiopulmonary arrest patients occurred in hospital were carried out CPR with Autopulse ( zoll) type instrument ( named test group ) and with manual CPR technique ( named control group ) respectively. Compare the circulation, respiration, CPR success rate and 24h survival rate of the patients in the two groups. Results Mean arterial pressure and pulse oxygen saturation levels of the test group were higher than those of the control group, with statistical significance ( P < 0. 05 ); Spontaneous circulation recovery time in the test group was less than that of the control group [ ( 6. 1 ± 1. 8 ) minutes vs ( 15. 2 ± 2. 3 ) minutes, P < 0. 05 ]; CPR success rate of the test group was higher than that of the control group ( 70. 8% vs 33. 3% , P<0.0l); 24 h survival rate of the test group was higher than that of the control group, with

  19. SW radiative effect of aerosol in GRAPES_GFS

    Science.gov (United States)

    Chen, Qiying

    2017-04-01

    The aerosol particles can scatter and absorb solar radiation, and so change the shortwave radiation absorbed by the atmosphere, reached the surface and that reflected back to outer space at TOA. Since this process doesn't interact with other processes, it is called direct radiation effect. The clear sky downward SW and net SW fluxes at the surface in GRAPES_GFS of China Meteorological Administration are overestimated in Northern multitudes and Tropics. The main source of these errors is the absence of aerosol SW effect in GRAPES_GFS. The climatic aerosol mass concentration data, which include 13 kinds of aerosol and their 14 SW bands optical properties are considered in GRAPES_GFS. The calculated total optical depth, single scatter albedo and asymmetry factor are used as the input to radiation scheme. Compared with the satellite observation from MISER, the calculated total optical depth is in good consistent. The seasonal experiments show that, the summer averaged clear sky radiation fluxes at the surface are improved after including the SW effect of aerosol. The biases in the clear sky downward SW and net SW fluxes at the surface in Northern multitudes and Tropic reduced obviously. Furthermore, the weather forecast experiments also show that the skill scores in Northern hemisphere and East Asia also become better.

  20. Rationale, design, and implementation protocol of an electronic health record integrated clinical prediction rule (iCPR randomized trial in primary care

    Directory of Open Access Journals (Sweden)

    Wisnivesky Juan

    2011-09-01

    Full Text Available Abstract Background Clinical prediction rules (CPRs represent well-validated but underutilized evidence-based medicine tools at the point-of-care. To date, an inability to integrate these rules into an electronic health record (EHR has been a major limitation and we are not aware of a study demonstrating the use of CPR's in an ambulatory EHR setting. The integrated clinical prediction rule (iCPR trial integrates two CPR's in an EHR and assesses both the usability and the effect on evidence-based practice in the primary care setting. Methods A multi-disciplinary design team was assembled to develop a prototype iCPR for validated streptococcal pharyngitis and bacterial pneumonia CPRs. The iCPR tool was built as an active Clinical Decision Support (CDS tool that can be triggered by user action during typical workflow. Using the EHR CDS toolkit, the iCPR risk score calculator was linked to tailored ordered sets, documentation, and patient instructions. The team subsequently conducted two levels of 'real world' usability testing with eight providers per group. Usability data were used to refine and create a production tool. Participating primary care providers (n = 149 were randomized and intervention providers were trained in the use of the new iCPR tool. Rates of iCPR tool triggering in the intervention and control (simulated groups are monitored and subsequent use of the various components of the iCPR tool among intervention encounters is also tracked. The primary outcome is the difference in antibiotic prescribing rates (strep and pneumonia iCPR's encounters and chest x-rays (pneumonia iCPR only between intervention and control providers. Discussion Using iterative usability testing and development paired with provider training, the iCPR CDS tool leverages user-centered design principles to overcome pervasive underutilization of EBM and support evidence-based practice at the point-of-care. The ongoing trial will determine if this collaborative

  1. Drilling, completion, stimulation, and testing of Hardy HW{number_sign}1 well, Putnam County, West Virginia. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Overbey, W.K. Jr.; Carden, R.S.; Locke, C.D.; Salamy, S.P.

    1992-03-01

    This report discusses the detailed field operations in drilling, logging, casing, completing, stimulating and testing the Hardy HW No. l well located in Union District, Putnam County, West Virginia. The project was designed and managed by BDM in cooperation with Cabot Oil and Gas Corporation. The well was spudded on November 29, 1989 and was completed at a total measured depth of 6406 feet on December 29, 1989. The well was drilled on an average azimuth of 335 degrees with a total horizontal displacement of 2618 feet. Approximately 1035 feet of the well had an inclination higher than 86 degrees, while 2212 feet of the well had an inclination greater than 62 degrees. The well was partitioned into five zones for stimulation purposes. Four zones were stimulated during three stimulation operations (Zones 3 and 4 were stimulated together). Zone 1 stimulation was a successful foam frac while the stimulations on Zones 2, 3-4 were Partially successful. Initial gas production rates were 4.5 times greater than the natural production rate. After 21 months, gas produced from the BDM/Cabot well has declined at a rate about one-half that of a conventional vertical well in the area. This horizontal well is projected to produce 475 million cubic feet of gas over a 30-year period.

  2. Drilling, completion, stimulation, and testing of Hardy HW[number sign]1 well, Putnam County, West Virginia

    Energy Technology Data Exchange (ETDEWEB)

    Overbey, W.K. Jr.; Carden, R.S.; Locke, C.D.; Salamy, S.P.

    1992-03-01

    This report discusses the detailed field operations in drilling, logging, casing, completing, stimulating and testing the Hardy HW No. l well located in Union District, Putnam County, West Virginia. The project was designed and managed by BDM in cooperation with Cabot Oil and Gas Corporation. The well was spudded on November 29, 1989 and was completed at a total measured depth of 6406 feet on December 29, 1989. The well was drilled on an average azimuth of 335 degrees with a total horizontal displacement of 2618 feet. Approximately 1035 feet of the well had an inclination higher than 86 degrees, while 2212 feet of the well had an inclination greater than 62 degrees. The well was partitioned into five zones for stimulation purposes. Four zones were stimulated during three stimulation operations (Zones 3 and 4 were stimulated together). Zone 1 stimulation was a successful foam frac while the stimulations on Zones 2, 3-4 were Partially successful. Initial gas production rates were 4.5 times greater than the natural production rate. After 21 months, gas produced from the BDM/Cabot well has declined at a rate about one-half that of a conventional vertical well in the area. This horizontal well is projected to produce 475 million cubic feet of gas over a 30-year period.

  3. Degradation of Swainsonine by the NADP-Dependent Alcohol Dehydrogenase A1R6C3 in Arthrobacter sp. HW08

    Directory of Open Access Journals (Sweden)

    Yan Wang

    2016-05-01

    Full Text Available Swainsonine is an indolizidine alkaloid that has been found in locoweeds and some fungi. Our previous study demonstrated that Arthrobacter sp. HW08 or its crude enzyme extract could degrade swainsonie efficiently. However, the mechanism of swainsonine degradation in bacteria remains unclear. In this study, we used label-free quantitative proteomics method based on liquid chromatography-electrospray ionization-tandem mass spectrometry to dissect the mechanism of swainsonine biodegradation by Arthrobacter sp. HW08. The results showed that 129 differentially expressed proteins were relevant to swainsonine degradation. These differentially expressed proteins were mostly related to the biological process of metabolism and the molecular function of catalytic activity. Among the 129 differentially expressed proteins, putative sugar phosphate isomerase/epimerase A1R5X7, Acetyl-CoA acetyltransferase A0JZ95, and nicotinamide adenine dinucleotide phosphate (NADP-dependent alcohol dehydrogenase A1R6C3 were found to contribute to the swainsonine degradation. Notably, NADP-dependent alcohol dehyrodgenase A1R6C3 appeared to play a major role in degrading swainsonine, but not as much as Arthrobacter sp. HW08 did. Collectively, our findings here provide insights to understand the mechanism of swainsonine degradation in bacteria.

  4. Construction of Genomic Library for Marine Pseudomonas HW08 and Analysis of Its Sequence Function%海洋假单胞杆菌HW08基因组文库的构建及序列功能分析

    Institute of Scientific and Technical Information of China (English)

    郝建华; 刘均忠; 王芳; 纪晓峰; 孙谧

    2012-01-01

    A 1~2 kb DNA fragment of HW08 genome was obtained by ultrasonic treatment, and the genomic library of HW08 was constructed after connecting the pUC18 plasmid with the obtained fragment and transformation. The random selected 200 clones were sequenced and analyzed in order to quick analyze the genome of marine pseudomonas HW08. The results showed that a partial genomic library of HW08 was constructed, and the obtained 173 sequences have seven vector sequences and seven contigs, in which the longest contig is the fourth contig which contained Chemotaxis Protein, Hypothetical protein and Lad family transcription regulator. The third contig is DNA repair protein, and its maximum similarity is 83%. Among the 166 sequences, the enzyme occupied most of the part; meanwhile 37 new genes were also included.%通过超声波处理HW08基因组,将获得的1~2KB DNA片段与pUC18质粒进行连接后转化,构建文库.随机筛选200个克隆进行序列测定,快速分析了海洋假单胞杆茵HW08基因组.结果表明:构建了HW08菌株的基因组部分文库,获得序列173个,包含7个载体序列和7个重叠群,其中最长重叠群为重叠群4,包含3段基因序列,分别为Chemotaxis Protein、Hypothetical protein和LacI family transcription regulator.重叠群3为DNA修复蛋白,其最大相似性为83%.166个序列中酶类占绝大部分,同时也包含37个新基因.

  5. Improved Design of CPR1000 Nuclear Power Plant Reactor Protection and Control System%CPR1000核电站反应堆保护及控制系统的设计改进

    Institute of Scientific and Technical Information of China (English)

    乐可佳

    2016-01-01

    Ningde nuclear power plant is the most advanced CPR1000 digital nuclear power plant in China. It is the first nuclear power plant after the Fukushima nuclear accident. Reactor protection and control system during the production and construction of a significant design improvements, it is worth learning from other nuclear power plants.%宁德核电站是我国最先进的CPR1000数字化核电站,是福岛核事故后正式商运的第一台核电站。反应堆保护及控制系统在生产建设期间进行了重大的设计改进,值得其他核电站借鉴。

  6. Manual Cardiopulmonary Resuscitation Versus CPR Including a Mechanical Chest Compression Device in Out-of-Hospital Cardiac Arrest: A Comprehensive Meta-analysis From Randomized and Observational Studies

    NARCIS (Netherlands)

    Bonnes, J.L.; Brouwer, M.A.; Navarese, E.P.; Verhaert, D.V.; Verheugt, F.W.; Smeets, J.L.; Boer, M.J. de

    2016-01-01

    STUDY OBJECTIVE: Mechanical chest compression devices have been developed to facilitate continuous delivery of high-quality cardiopulmonary resuscitation (CPR). Despite promising hemodynamic data, evidence on clinical outcomes remains inconclusive. With the completion of 3 randomized controlled

  7. A ventilation technique for oxygenation and carbon dioxide elimination in CPR: Continuous insufflation of oxygen at three levels of pressure in a pig model

    NARCIS (Netherlands)

    Ordelman, S.C.; Aelen, P.; Woerlee, P.H.; Berkom, P.F. van; Scheffer, G.J.; Noordergraaf, G.J.

    2015-01-01

    AIM: Pulmonary ventilation remains an important part of cardiopulmonary resuscitation, affecting gas exchange and haemodynamics. We designed and studied an improved method of ventilation for CPR, constructed specifically to support both gas exchange and haemodynamics. This method uses continuous ins

  8. An evaluation of 9-1-1 calls to assess the effectiveness of dispatch-assisted cardiopulmonary resuscitation (CPR instructions: design and methodology

    Directory of Open Access Journals (Sweden)

    Stiell Ian G

    2008-11-01

    Full Text Available Abstract Background Cardiac arrest is the leading cause of mortality in Canada, and the overall survival rate for out-of-hospital cardiac arrest rarely exceeds 5%. Bystander cardiopulmonary resuscitation (CPR has been shown to increase survival for cardiac arrest victims. However, bystander CPR rates remain low in Canada, rarely exceeding 15%, despite various attempts to improve them. Dispatch-assisted CPR instructions have the potential to improve rates of bystander CPR and many Canadian urban communities now offer instructions to callers reporting a victim in cardiac arrest. Dispatch-assisted CPR instructions are recommended by the International Guidelines on Emergency Cardiovascular Care, but their ability to improve cardiac arrest survival remains unclear. Methods/Design The overall goal of this study is to better understand the factors leading to successful dispatch-assisted CPR instructions and to ultimately save the lives of more cardiac arrest patients. The study will utilize a before-after, prospective cohort design to specifically: 1 Determine the ability of 9-1-1 dispatchers to correctly diagnose cardiac arrest; 2 Quantify the frequency and impact of perceived agonal breathing on cardiac arrest diagnosis; 3 Measure the frequency with which dispatch-assisted CPR instructions can be successfully completed; and 4 Measure the impact of dispatch-assisted CPR instructions on bystander CPR and survival rates. The study will be conducted in 19 urban communities in Ontario, Canada. All 9-1-1 calls occurring in the study communities reporting out-of-hospital cardiac arrest in victims 16 years of age or older for which resuscitation was attempted will be eligible. Information will be obtained from 9-1-1 call recordings, paramedic patient care reports, base hospital records, fire medical records and hospital medical records. Victim, caller and system characteristics will be measured in the study communities before the introduction of dispatch

  9. A knockout strain of CPR1 induced during fermentation of Saccharomyces cerevisiae KNU5377 is susceptible to various types of stress.

    Science.gov (United States)

    Kim, Il-Sup; Yun, Hae-Sun; Park, In-Su; Sohn, Ho-Yong; Iwahashi, Hitoshi; Jin, Ing-Nyol

    2006-10-01

    To investigate the tolerance factor of Saccharomyces cerevisiae KNU5377 against various types of environmental stress during fermentation, we identified the protein that is upregulated at high temperatures. The highly upregulated protein was high-score-matched as a cytoplasmic peptidyl-prolyl cis-trans isomerase, cyclophilin (Cpr1p), by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF). We constructed a CPR1-deleted KNU5377 strain (KNU5377Y cpr1Delta) to determine the roles of the protein under fermentative or stress condition. The growth of the S. cerevisiae KNU5377Y cpr1Delta strain was completely inhibited under the following conditions: heat (40 degrees C), hydrogen peroxide (20-30 mM), menadione (0.3 mM), ethanol (16%), sulfuric acid (5 mm), and lactic acid (0.4-0.8%). However, the wild-type and cpr1Delta mutant of S. cerevisiae BY4741 as a positive control did not show differences in sensitivity to stress. It is interesting to note that the wild-type KNU5377Y and KNU5377Y cpr1Delta mutant showed high sensitivity against various stresses, particularly, acid stress such as in the presence of sulfuric and lactic acid. Although the alcohol fermentation rate of the KNU5377Y cpr1Delta mutant markedly decreased with an increase in temperature up to 40 degrees C, we observed no decrease in that of the wild-type strain under the same conditions. These results suggest that CPR1 contributes to the stress tolerance of KNU5377 against various types of environmental stress caused during fermentation, thus leading to the physiological role of maintaining an alcohol fermentation yield, even at high temperatures such as 40 degrees C.

  10. Optimizing Chest Compression to Rescue Ventilation Ratios During One-Rescuer CPR by Professionals and Lay Persons: Children are Not Just Little Adults

    OpenAIRE

    Babbs, Charles F.; Nadkarni, Vinay

    2003-01-01

    Objective: To estimate the optimum ratio of chest compressions to ventilations for onerescuer CPR that maximizes systemic oxygen delivery in children. Method: Equations describing oxygen delivery and blood flow during CPR as functions of the number of compressions and the number of ventilations delivered over time were adapted from the former work of Babbs and Kern. These equations were solved explicitly as a function of body weight, using scaling algorithms based upon principles of developme...

  11. Keep pushing! Limiting interruptions to CPR; bag-valve mask versus i-gel® airway ventilation

    Directory of Open Access Journals (Sweden)

    Craig Vincent-Lambert

    2016-12-01

    Conclusion: The use of the i-gel® airway resulted in a considerable decrease in the amount of time spent on ventilations and in more compressions being performed. The overall reduction in HOT was, however, offset by the time it took to secure the device. Further investigation into the use and securing of the i-gel® airway in single rescuer CPR is recommended.

  12. How to Improve Our Nosocomialsuccess Average of CPR%如何提高院内CPR成功率

    Institute of Scientific and Technical Information of China (English)

    李生浩

    2013-01-01

    Cardiopulmonary resuscitation,or CPR,had maken so many patients survive from sudden death,which experienced a lot of majorizations and changes during the latest decades.The newest standards of CPR were delivered by American Heart Association,or AHA,in 2010,and have heightened the survive rate so much.However, observing the developing history and the current situation of this technique,we can note that people are just training about CPR itself,yet it is not enough in the aspects of the team cooperation,the regularity of training,and the conscious initiative of medicallstaf .Success average of CPR can also be elevated a lot,immediately these ideas are accepted and learntcomprehensively.%心肺复苏术(CPR)无疑已经挽救了许多生命,历经数10年的优化和改进,2010年美国心脏协会(AHA)提出心肺复苏的新标准,进一步提高猝死患者的生存率,但从该技术的发展历程及现状来看,大多局限于对该技术本身的学习,然而对于团队协作、定期培训、医务人员的主观能动性等方面并未得到很好的推广,如果这些理念能得到广泛推广和认识,那么CPR成功率仍有提高的空间。

  13. Like Father, Like Son? A Comparison of the Foreign Policies of George H.W. Bush and George W. Bush

    Directory of Open Access Journals (Sweden)

    Marc J. O'Reilly

    2009-12-01

    Full Text Available Este artículo aplica aproximaciones cognitivas (por ejemplo, la del liderazgo y poliheurísticas a la toma de decisiones en política exterior para explicar las variaciones en las políticas de George H. W. Bush y George W. Bush. Yuxtaponer estos enfoques relacionados ilustra el cómo y el por qué del proceso  de toma de decisiones de los presidentes estadounidenses, proporcionando un sintético pero más trabajado, análisis en la comprensión de la política exterior, especialmente cuando ésta afecta a las presidencias. La sección inicial del artículo confronta las dos teorías. La siguiente sección examina decisiones importantes a través de estudios de caso (uno por cada administración. La sección final analiza las decisiones dentro del contexto teórico. Mientras que el artículo enfatiza el nivel individual de análisis, factores tanto estructurales como doméstico también serán tenidos en cuenta._______________________ABSTRACT:This article applies cognitive (i.e., leadership and poliheuristic approaches to foreign-policy decision making to explain variances in the policies of George H.W. Bush and George W. Bush. Juxtaposing these related approaches highlights the how and why of presidential decision making, providing a synthetic, though more cogent, understanding of foreign-policy analysis -- especially as it pertains to presidencies. The initial section of the article discusses the two theories. The following section examines important decisions via case studies – one for each administration. The final section analyzes the decisions in the context of the theories. While this article emphasizes the individual level of analysis, structural as well as domestic factors will also be discussed.

  14. Development of a smart backboard system for real-time feedback during CPR chest compression on a soft back support surface.

    Science.gov (United States)

    Gohier, Francis; Dellimore, Kiran; Scheffer, Cornie

    2013-01-01

    The quality of cardiopulmonary resuscitation (CPR) is often inconsistent and frequently fails to meet recommended guidelines. One promising approach to address this problem is for clinicians to use an active feedback device during CPR. However, one major deficiency of existing feedback systems is that they fail to account for the displacement of the back support surface during chest compression (CC), which can be important when CPR is performed on a soft surface. In this study we present the development of a real-time CPR feedback system based on an algorithm which uses force and dual-accelerometer measurements to provide accurate estimation of the CC depth on a soft surface, without assuming full chest decompression. Based on adult CPR manikin tests it was found that the accuracy of the estimated CC depth for a dual accelerometer feedback system is significantly better (7.3% vs. 24.4%) than for a single accelerometer system on soft back support surfaces, in the absence or presence of a backboard. In conclusion, the algorithm used was found to be suitable for a real-time, dual accelerometer CPR feedback application since it yielded reasonable accuracy in terms of CC depth estimation, even when used on a soft back support surface.

  15. CPR Appliance:Applications and Prospects%心肺复苏器的应用及展望

    Institute of Scientific and Technical Information of China (English)

    郭凯; 张源波; 周荣斌

    2014-01-01

    心肺复苏器是有望替代传统人工胸外按压的器材,正逐步应用于现场急救和临床抢救工作当中。本文介绍了胸外按压泵机制的理念沿袭、不同心肺复苏器设计的理论依据和国内外常见心肺复苏器的使用方法及特点;同时对心肺复苏器的发展趋势和改进方向进行了展望。以期为心肺复苏器更有效地应用于临床抢救中提供有益借鉴和推广。%Cardiopulmonary resuscitation appliance is a promising substitution for traditional artificial compression and it is gradual y applied in the fields of first aid and salvage.This paper introduces the conception of pump mechanism of chest compression,the theoretical basis of design in various CPR appliance and application procedure as wel as characteristics of common CPR appliance at home and abroad.Besides,the paper shows future outlook in development tendency and improvement direction of the apparatus.Al this can be made use for reference and promotion of CPR appliance in the application of clinical emergency treatment.

  16. Is there a place for CPR and sustained physiological support in brain-dead non-donors?

    Science.gov (United States)

    Brown, Stephen D

    2017-02-24

    This article addresses whether cardiopulmonary resuscitation (CPR) and sustained physiological support should ever be permitted in individuals who are diagnosed as brain dead and who had held previously expressed moral or religious objections to the currently accepted criteria for such a determination. It contrasts how requests for care would normally be treated in cases involving a brain-dead individual with previously expressed wishes to donate and a similarly diagnosed individual with previously expressed beliefs that did not conform to a brain-based conception of death. The paper first focuses narrowly on requests for CPR and then expands its scope to address extended physiological support. It describes how refusing the brain-dead non-donor's requests for either CPR or extended support would represent enduring harm to the antemortem or previously autonomous individual by negating their beliefs and self-identity. The paper subsequently discusses potential implications of policy that would allow greater accommodations to those with conscientious objections to currently accepted brain-based death criteria, such as for cost, insurance, higher brain formulations and bedside communication. The conclusion is that granting wider latitude to personal conceptions around the definition of death, rather than forcing a contested definition on those with valid moral and religious objections, would benefit both individuals and society.

  17. Aseismic safety analysis of a prestressed concrete containment vessel for CPR1000 nuclear power plant

    Science.gov (United States)

    Yi, Ping; Wang, Qingkang; Kong, Xianjing

    2017-01-01

    The containment vessel of a nuclear power plant is the last barrier to prevent nuclear reactor radiation. Aseismic safety analysis is the key to appropriate containment vessel design. A prestressed concrete containment vessel (PCCV) model with a semi-infinite elastic foundation and practical arrangement of tendons has been established to analyze the aseismic ability of the CPR1000 PCCV structure under seismic loads and internal pressure. A method to model the prestressing tendon and its interaction with concrete was proposed and the axial force of the prestressing tendons showed that the simulation was reasonable and accurate. The numerical results show that for the concrete structure, the location of the cylinder wall bottom around the equipment hatch and near the ring beam are critical locations with large principal stress. The concrete cracks occurred at the bottom of the PCCV cylinder wall under the peak earthquake motion of 0.50 g, however the PCCV was still basically in an elastic state. Furthermore, the concrete cracks occurred around the equipment hatch under the design internal pressure of 0.4MPa, but the steel liner was still in the elastic stage and its leak-proof function soundness was verified. The results provide the basis for analysis and design of containment vessels.

  18. Shadows of CPR black holes and tests of the Kerr metric

    CERN Document Server

    Ghasemi-Nodehi, Masoumeh; Bambi, Cosimo

    2015-01-01

    We study the shadow of the Cardoso-Pani-Rico (CPR) black hole for different values of the black hole spin $a_*$, the deformation parameters $\\epsilon_3^t$ and $\\epsilon_3^r$, and the viewing angle $i$. We find that the main impact of the deformation parameter $\\epsilon_3^t$ is the change of the size of the shadow, while the deformation parameter $\\epsilon_3^r$ affects the shape of its boundary. In general, it is impossible to test the Kerr metric, because the shadow of a Kerr black hole can be reproduced quite well by a black hole with non-vanishing $\\epsilon_3^t$ or $\\epsilon_3^r$. Deviations from the Kerr geometry could be constrained in the presence of high quality data and in the favorable case of a black hole with high values of $a_*$ and $i$. However, the shadows of some black holes with non-vanishing $\\epsilon_3^r$ present peculiar features and the possible detection of these shadows could unambiguously distinguish these objects from the standard Kerr black holes of general relativity.

  19. Comparison of Knowledge of Medical and Paramedical Intern about of CPR, 2015

    Directory of Open Access Journals (Sweden)

    Nastoor Bekhradian

    2016-09-01

    Full Text Available Every day a number of people from the heart stops beating for most of them that this early cessation of heartbeat. With operations of CPR in 4 to 6 minutes of cardiopulmonary arrest and before the onset of brain death can be established circulation and survival for patients with the death of 2 to 4 folds. The aim of this study was to Comparison of knowledge of medical and paramedical intern about of CPCR, 2015. This descriptive analytical and sampling method was census. Restore their data using a standard questionnaire with Cronbach's alpha coefficient was 0.82 .Spss20 data using statistical software analysis and descriptive statistics and Chi-square test was used. The mean score of 3/6 students that showed poor knowledge of students participating in the study. The lowest score of zero and the highest score was 12. Was found between gender and level of knowledge (p=0/05. Between education and the knowledge of the relationship was not statistically significant (p=0/764. The knowledge of medical and paramedical students groups scheduled for next semester as part of the treatment system personnel are working poor and require special attention in order to provide guidelines for planning authorities to increase the awareness of students.

  20. Institutional property rights structure, common pool resource (CPR), tragedy of the urban commons: A Review

    Science.gov (United States)

    Ling, G.; Ho, C. S.; Ali, H. M.

    2014-02-01

    There have been a plethora of researches on the significance of public open space (POS) in contributing to societies' sustainability. However, by virtue of identified maladaptive policy-based-property rights structure, such a shared good becomes vulnerable to tragedy of the urban commons (overexploitation) that subsequently leads to burgeoning number of mismanaged POS e.g., degraded and unkempt urban public spaces. By scrutinising the literatures within property rights domain and commons resources, an objective is highlighted in this paper which is to insightfully discourse institutional property rights structure pertaining to the mechanism, roles and interrelationship between property-rights regimes, bundle of property rights and resource domains; types of goods on how they act upon and tie in the POS with the social quandary. In summary, urban POS tragedy can potentially be triggered by the institutional structure especially if the ownership is left under open-access resource regime and ill-defined property rights which both successively constitute the natures of Common Pool Resource (CPR) within the commons, POS. Therefore, this paper sparks an idea to policy makers that property rights structure is a determinant in sustainably governing the POS in which adaptive assignment of property regimes and property rights are impelled.

  1. YOGA – MODULATING COLD PRESSURE RESPONSE (CPR IN MIDDLE-AGED MEN

    Directory of Open Access Journals (Sweden)

    Pramod P. Kadu

    2016-06-01

    Full Text Available This study was conducted to show effects of yoga on cold pressor response (sympathetic function in middle-aged men. Objective of study is to assess cold pressor response in study and control groups. We selected 90 healthy volunteers between age group 35 – 50 years and divided into 2 groups. (1 Study group – 45. (2 Control group – 45. Control group does not perform any yoga or exercise during one year period, whereas yoga group (study group performs yoga for one year under supervision of yoga expert in yoga centre. In both the groups, cold pressor response was recorded at 0, 6 and 12 months. In control group, cold pressor response shows no significant change whereas study group showed significant reduction in rise from 18.13±2.97 to 13.55 ± 2.00 at 6 months and 13.11 ± 1.76 at 12 months showing F value – 65.33 (P value<0.001 which is highly significant. Rise in DBP also decreased from 15.11± 2.97 to 11.15 ± 1.83 at 6 months and 11.11 ± 1.82 at 12 months showing F – value 45.75 (P<0.001 which is also highly significant in study group. In conclusion, yoga done regularly for longterm improves sympathetic functions (CPR.

  2. RCRA Permit for a Hazardous Waste Management Facility Permit Number NEV HW0101 Annual Summary/Waste Minimization Report - Calendar Year 2014

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, Patrick [NSTec

    2015-02-17

    This report summarizes the EPA identification number of each generator from which the Permittee received a waste stream, a description and quantity of each waste stream in tons and cubic feet received at the facility, the method of treatment, storage, and/or disposal for each waste stream, a description of the waste minimization efforts undertaken, a description of the changes in volume and toxicity of waste actually received, any unusual occurrences, and the results of tank integrity assessments. This Annual Summary/Waste Minimization Report is prepared in accordance with Section 2.13.3 of Permit Number NEV HW0101.

  3. RCRA Permit for a Hazardous Waste Management Facility Permit Number NEV HW0101 Annual Summary/Waste Minimization Report Calendar Year 2011

    Energy Technology Data Exchange (ETDEWEB)

    NSTec Environmental Restoration

    2012-02-16

    This report summarizes the U.S. Environmental Protection Agency (EPA) identification number of each generator from which the Permittee received a waste stream; a description and quantity of each waste stream in tons and cubic feet received at the facility; the method of treatment, storage, and/or disposal for each waste stream; a description of the waste minimization efforts undertaken; a description of the changes in volume and toxicity of waste actually received; any unusual occurrences; and the results of tank integrity assessments. This Annual Summary/Waste Minimization Report is prepared in accordance with Section 2.13.3 of Permit Number NEV HW0101.

  4. RCRA Permit for a Hazardous Waste Management Facility Permit Number NEV HW0101 Annual Summary/Waste Minimization Report Calendar Year 2012, Nevada National Security Site, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, P. M.

    2013-02-21

    This report summarizes the U.S. Environmental Protection Agency (EPA) identification number of each generator from which the Permittee received a waste stream, a description and quantity of each waste stream in tons and cubic feet received at the facility, the method of treatment, storage, and/or disposal for each waste stream, a description of the waste minimization efforts undertaken, a description of the changes in volume and toxicity of waste actually received, any unusual occurrences, and the results of tank integrity assessments. This Annual Summary/Waste Minimization Report is prepared in accordance with Section 2.13.3 of Permit Number NEV HW0101, issued 10/17/10.

  5. Are sociodemographic characteristics associated with spatial variation in the incidence of OHCA and bystander CPR rates? A population-based observational study in Victoria, Australia.

    Science.gov (United States)

    Straney, Lahn D; Bray, Janet E; Beck, Ben; Bernard, Stephen; Lijovic, Marijana; Smith, Karen

    2016-11-07

    Rates of out-of-hospital cardiac arrest (OHCA) and bystander cardiopulmonary resuscitation (CPR) have been shown to vary considerably in Victoria. We examined the extent to which this variation could be explained by the sociodemographic and population health characteristics of the region. Using the Victorian Ambulance Cardiac Arrest Registry, we extracted OHCA cases occurring between 2011 and 2013. We restricted the calculation of bystander CPR rates to those arrests that were witnessed by a bystander. To estimate the level of variation between Victorian local government areas (LGAs), we used a two-stage modelling approach using random-effects modelling. Between 2011 and 2013, there were 15 830 adult OHCA in Victoria. Incidence rates varied across the state between 41.9 to 104.0 cases/100 000 population. The proportion of the population over 65, socioeconomic status, smoking prevalence and education level were significant predictors of incidence in the multivariable model, explaining 93.9% of the variation in incidence among LGAs. Estimates of bystander CPR rates for bystander witnessed arrests varied from 62.7% to 73.2%. Only population density was a significant predictor of rates in a multivariable model, explaining 73% of the variation in the odds of receiving bystander CPR among LGAs. Our results show that the regional characteristics which underlie the variation seen in rates of bystander CPR may be region specific and may require study in smaller areas. However, characteristics associated with high incidence and low bystander CPR rates can be identified and will help to target regions and inform local interventions to increase bystander CPR rates. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  6. A comparison of the outcome of CPR according to AHA 2005 ACLS and AHA 2010 ACLS guidelines in cardiac arrest: multicenter study.

    Science.gov (United States)

    Ocal, Oktay; Ozucelik, Dogac Niyazi; Avci, Akkan; Yazicioglu, Mustafa; Aydin, Yilmaz; Ayvaci, Baris Murat; Dogan, Halil; Aciksari, Kurtulus; Cukurova, Zafer

    2015-01-01

    The aim of this study was to evaluate whether there is a difference in the return of spontaneous circulation (ROSC) and survival with sequel-free recovery rates between the patients who underwent cardiopulmonary resuscitation (CPR) according to 2005 and 2010 guidelines. This study was conducted in the Bakırköy Dr. Sadi Konuk and Kartal Lütfi Kırdar Training and Research Hospital between dates of October 2010 and 28 February 2011 after approval of Ethics Committee. In the first months of the study, CPR was performed according to AHA 2005 ACLS guidelines (Group-1), while CPR was performed according to AHA 2010 ACLS guidelines after November 2010 (Group-2). Patients were assessed for neurological deficit with Cerebral Performance Categories Scale. Mean age was found as 69.01±13.05 (minimum: 21, maximum: 92) in 86 patients included. Of the 33 patients underwent CPR in the Group 1, ROSC was achieved in 51.5%; and 6.1% of these patients were discharged. Of the 53 patients underwent CPR in the Group 2, ROSC was achieved in 37.7%; and 9.4% of these patients were discharged. Although the number of living patients in Group 2 was higher than Group 1, the difference was not found statistically significant (5 versus 2), (P>0.05). But, neurological outcomes were found better with 2010 compared to 2005 guidelines (3/7 versus 0/2 good cerebral performance). It was found that the 2005 CPR guidelines practices in ED were more successful than the 2010 CPR guidelines practices in ROSC, but less successful in the rate of discharge from hospital and neurological sequel-free discharge rate.

  7. Impaired bioavailability and antiplatelet effect of high-dose clopidogrel in patients after cardiopulmonary resuscitation (CPR).

    Science.gov (United States)

    Součková, L; Opatřilová, R; Suk, P; Čundrle, I; Pavlík, M; Zvoníček, V; Hlinomaz, O; Šrámek, V

    2013-03-01

    Bioavailability of clopidogrel in the form of crushed tablets administered via nasogastric tube (NGT) has not been established in patients after cardiopulmonary resuscitation. Therefore, we performed a study comparing pharmacokinetic and pharmacodynamic response to high loading dose of clopidogrel in critically ill patients after cardiopulmonary resuscitation (CPR) with patients scheduled for elective coronary angiography with stent implantation. In the NGT group (nine patients, after cardiopulmonary resuscitation, mechanically ventilated, therapeutic hypothermia), clopidogrel was administered in the form of crushed tablets via NGT. Ten patients undergoing elective coronary artery stenting took clopidogrel per os (po) in the form of intact tablets. Pharmacokinetics of clopidogrel was measured with high-performance liquid chromatography (HPLC) before and at 0.5, 1, 6, 12, 24 h after administration of a loading dose of 600 mg. In five patients in each group, antiplatelet effect was measured with thrombelastography (TEG; Platelet Mapping) before and 24 h after administration. The carboxylic acid metabolite of clopidogrel was detected in all patients in the po group. In eight patients, the maximum concentration was measured in the range of 0.5-1 h after the initial dose. In four patients in the of NGT group, the carboxylic acid metabolite of clopidogrel was undetectable and in the remaining patients was significantly delayed (peak values at 12 h). All patients in the po group reached clinically relevant (>50 %) inhibition of thrombocyte adenosine diphosphate (ADP) receptor after 24 h compared with only two in the NGT group (p = 0.012). There was a close correlation between peak of inactive clopidogrel metabolite plasmatic concentration and inhibition of the ADP receptor (r = 0.79; p < 0.001). The bioavailability of clopidogrel in critically ill patients after cardiopulmonary resuscitation is significantly impaired compared with stable patients. Therefore

  8. Three different CPR management models for riverine nitrogen polluters in Sweden

    Energy Technology Data Exchange (ETDEWEB)

    Arheimer, B.

    1997-12-31

    Sweden has failed in the environmental goal of reducing the nitrogen transport to the Baltic Sea by 50 per cent in ten years, mainly because of the large amounts of nitrogen still leaching from arable land. The riverine nitrogen problem can be formulated in terms of a CPR problem, as the property rights of the river water are undefined and it is possible to free-ride in the maintenance of the resource by polluting it for personal aim. Swedish water management at present is dominated by a command-and-control policy. However, to master the situation, various propositions of changed institutional arrangements for better management of water resources have been presented recently. This chapter describes and discusses three models that have been proposed for water management in the Swedish environmental policy debate: the community model, the negotiation model and the market model. To be economically efficient and ecologically sustainable, all of these models must be in accordance with local environmental, socio-economic and cultural conditions. According to the analysis, the proposed management models have about the same institutional requirements, although the sensitivity to various requirements may differ among the models. In the chapter it is argued that new policy implementation in Sweden should include regional water administration boards, where monitoring and problem analysis are kept within single catchments. Problem solution should be decentralized so that sub basins are managed according to the model most in accordance with local conditions. As long as the various requests for model success are met, different management models may be used in different parts of the same watershed. This may be possible since the overwhelming need of institutional arrangements is about the same for the three proposed management models and, consequently, they do not exclude each other 42 refs, 3 figs, 1 tab

  9. The validity and reliability of the handheld SW-100 autokeratometer

    Directory of Open Access Journals (Sweden)

    Eghosasere Iyamu

    2015-03-01

    Full Text Available Background: The agreement of new instruments or clinical tests with other instruments or tests defines the possibility of these being used interchangeably.Aim: To investigate the validity and reliability of the SW-100 autokeratometer using a Bausch & Lomb (B&L keratometer as the ‘gold standard’. Methods: Eighty subjects (80 right eyes aged between 21 and 38 years were recruited. For intra-test repeatability, two measurements of the corneal radius of curvature were taken with the SW-100 and B&L keratometers. Forty of the 80 subjects participated in the inter-test repeatability measurement.Results: Corneal radius of curvature was found to be statistically different between the two instruments (p < 0.001, with the SW-100 providing slightly flatter values of 0.11 mm and 0.05 mm for the horizontal and vertical meridians, respectively, than the B&L keratometer. The average corneal curvature was 0.07 mm flatter with the SW-100 autokeratometer than with the B&L device. Agreement between the SW-100 and B&L keratometers’ axes was 45% within ± 5°, 60.3% within ± 10°, 78.8% within ± 15°, 80.3% within ± 20°, and 88.7% within ± 40°. Intertest repeatability was better for the B&L device than the SW-100 and showed no significant difference between the two sessions. Both instruments demonstrated comparable intrasession repeatability. As such, both instruments were comparatively reliable (per coefficients of repeatability. The range of limits of agreement of ± 0.14 mm (horizontal meridian and ± 0.17 mm (vertical meridian between the SW-100 and B&L devices showed good agreement.Conclusion: The results suggest that the SW-100 autokeratometer is a reliable and objective instrument that, however, provides flatter radii of curvature measurements than the B&L keratometer. A compensating factor incorporated into the instrument could reduce the difference between the two instruments and make them more interchangeable. 

  10. Three-dimensional Steady State Thermal-hydraulic Analysis of Secondary Side for CPR1000 Steam Generator%CPR1000蒸汽发生器二次侧三维稳态热工水力分析

    Institute of Scientific and Technical Information of China (English)

    莫少嘉; 盛朝阳; 任红兵; 秦加明; 左超平

    2015-01-01

    A three‐dimensional steady state analysis software GENEPI was used to do the thermal‐hydraulic analysis of tube bundle region for secondary side of CPR1000 steam generator .The porous medium model and local pressure‐drop model were used in GENEPI to represent the tubes and pressure‐drop of the complex geometry .The flow and temperature fields of the tube bundle in secondary side were analyzed and the high‐est steam quality in the tube bundle is 0.3 .The kinetic energy of typical tubes was acquired by a computer code as the input for the flow‐induced vibration analysis .The result shows that the flow‐induced vibration in heat transfer tubes is acceptable .At the same time ,the flow and temperature fields near the tube sheet were analyzed and the fouling deposit region was predicted based on such a model and working condition .The result can be used as the input for the design of draining pipe .The calculation results verify the rationality for the design of the CPR1000 steam generator secondary side tube bundle region .%采用三维稳态分析软件GENEPI ,对CPR1000蒸汽发生器二次侧管束区进行了热工水力计算,利用多孔介质及局部阻力系数来表征传热管及各几何部件的复杂结构和压降影响,得到了二次侧管束区流场、温度场等的分布情况。计算结果表明:管束区最大干度为0.3;将典型传热管的动能数据提供给流致振动软件进行计算分析,结果显示在本工况下,传热管的流致振动在可接受范围内;对管板附近的流场及温度场进行分析,预测了此模型及工况下的泥渣沉积区域,为排污管的设计提供了输入数据。计算结果验证了CPR1000蒸汽发生器二次侧管束区设计的合理性。

  11. Structural and functional basis of transcriptional regulation by TetR family protein CprB from S. coelicolor A3(2).

    Science.gov (United States)

    Bhukya, Hussain; Bhujbalrao, Ruchika; Bitra, Aruna; Anand, Ruchi

    2014-09-01

    Antibiotic production and resistance pathways in Streptomyces are dictated by the interplay of transcriptional regulatory proteins that trigger downstream responses via binding to small diffusible molecules. To decipher the mode of DNA binding and the associated allosteric mechanism in the sub-class of transcription factors that are induced by γ-butyrolactones, we present the crystal structure of CprB in complex with the consensus DNA element to a resolution of 3.25 Å. Binding of the DNA results in the restructuring of the dimeric interface of CprB, inducing a pendulum-like motion of the helix-turn-helix motif that inserts into the major groove. The crystal structure revealed that, CprB is bound to DNA as a dimer of dimers with the mode of binding being analogous to the broad spectrum multidrug transporter protein QacR from the antibiotic resistant strain Staphylococcus aureus. It was demonstrated that the CprB displays a cooperative mode of DNA binding, following a clamp and click model. Experiments performed on a subset of DNA sequences from Streptomyces coelicolor A3(2) suggest that CprB is most likely a pleiotropic regulator. Apart from serving as an autoregulator, it is potentially a part of a network of proteins that modulates the γ-butyrolactone synthesis and antibiotic regulation pathways in S. coelicolor A3(2).

  12. Extracorporeal life support (ECLS) for cardiopulmonary resuscitation (CPR) with pulmonary embolism in surgical patients - a case series.

    Science.gov (United States)

    Swol, J; Buchwald, D; Strauch, J; Schildhauer, T A

    2016-01-01

    Extracorporeal life support (ECLS) devices maintain the circulation and oxygenation of organs during acute right ventricular failure and cardiogenic shock, bypassing the lungs. A pulmonary embolism can cause this life-threatening condition. ECLS is a considerably less invasive treatment than surgical embolectomy. Whether to bridge embolectomy or for a therapeutic purpose, ECLS is used almost exclusively following failure of all other therapeutic options. From January 1, 2008 to June 30, 2014, five patients in cardiac arrest and with diagnosed pulmonary embolism (PE) were cannulated with the ECLS system. PE was diagnosed using computer tomography scanning or echocardiography. Cardiac arrest was witnessed in the hospital in all cases and CPR (cardiopulmonary resuscitation) was initiated immediately. Cannulation of the femoral vein and femoral artery was always performed under CPR conditions. Right heart failure regressed during the ECLS therapy, usually under a blood flow of 4-5 L/min after 48 hours. Three patients were weaned from ECLS and one patient became an organ donor. Finally, two of the five PE patients treated with ECLS were discharged from inpatient treatment without neurological dysfunction. The duration of ECLS therapy depends on the patient's condition. Irreversible damage to the organs after hypoxemia limits ECLS treatment and leads to futile multiorgan failure. Hemorrhages after thrombolysis and cerebral dysfunction were further complications. Veno-arterial cannulation for ECLS can be feasibly achieved and should be established during active CPR for cardiac arrest. In the case of PE, the immediate diagnosis and rapid implantation of the system are decisive for therapeutic success. © The Author(s) 2015.

  13. Verbascum lindae (Scrophulariaceae), a new species from SW Anatolia, Turkey

    DEFF Research Database (Denmark)

    Parolly, Gerald; Tan, Kit

    2007-01-01

    Verbascum lindae, a taxonomically isolated limestone chasmophyte from the vilayet of Isparta in SW Anatolia is described as a species new to science and illustrated. Its affinities with other Anatolian Verbascum species, which have either a chasmophytic habit or at least a woody base, are discussed....

  14. Seaweeds of the Spermonde Archipelago, SW Sulawesi, Indonesia

    NARCIS (Netherlands)

    Verheij, E.; Prud’homme van Reine, W.F.

    1993-01-01

    Seaweeds are important components of tropical reef systems. The present paper deals with the Chlorophyta, Phaeophyta and noncoralline Rhodophyta collected by the first author in the Spermonde Archipelago, SW Sulawesi, Indonesia, during the Buginesia-III project (November 1988-November 1990). Additio

  15. The continuous quality improvement project for telephone-assisted instruction of cardiopulmonary resuscitation increased the incidence of bystander CPR and improved the outcomes of out-of-hospital cardiac arrests.

    Science.gov (United States)

    Tanaka, Yoshio; Taniguchi, Junro; Wato, Yukihiro; Yoshida, Yutaka; Inaba, Hideo

    2012-10-01

    In 2007, the Ishikawa Medical Control Council initiated the continuous quality improvement (CQI) project for telephone-assisted cardiopulmonary resuscitation (telephone-CPR), which included instruction on chest-compression-only CPR, education on how to recognise out-of-hospital cardiac arrests (OHCAs) with agonal breathing, emesis and convulsion, recommendations for on-line or redialling instructions and feedback from emergency physicians. This study aimed to investigate the effect of this project on the incidence of bystander CPR and the outcomes of OHCAs. The baseline data were prospectively collected on 4995 resuscitation-attempted OHCAs, which were recognised or witnessed by citizens rather than emergency medical technicians during the period of February 2004 to March 2010. The incidence of telephone-CPR and bystander CPR, as well as the outcomes of the OHCAs, was compared before and after the project. The incidence of telephone-CPR and bystander CPR significantly increased after the project (from 42% to 62% and from 41% to 56%, respectively). The incidence of failed telephone-CPR due to human factors significantly decreased from 30% to 16%. The outcomes of OHCAs significantly improved after the projects. A multiple logistic regression analysis revealed that the CQI project is one of the independent factors associated with one-year (1-Y) survival with favourable neurological outcomes (odds ratio=1.81, 95% confidence interval=1.20-2.76). The CQI project for telephone-CPR increased the incidence of bystander CPR and improved the outcome of OHCAs. A CQI project appeared to be essential to augment the effects of telephone-CPR. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  16. Convective overshooting top detection with MSG SEVIRI, Himawari-8 AHI, and CloudSat CPR data

    Science.gov (United States)

    Im, J.; Kim, M.; Park, S.

    2015-12-01

    Overshooting Tops (OTs) are the clouds that penetrate into the tropopause and grow to the bottom of stratosphere at the top layer of cumulonimbus with very strong updraft. Severe weather conditions such as ground lightning, large hail, strong winds, and heavy rainfall can cause in the cumulonimbus clouds with OTs, with turbulence and lightning occurring very frequently in the area near OTs. In terms of aviation operations, OTs are a very important risk factor. According to Federal Aviation Administration, 509 cases of 4,326 weather-related events from 1992 to 2001were caused by turbulences. The detection of OTs is important to predict the degree and location of severe weather conditions such as turbulence, lightning, and thunderstorms. There are two methods widely used to detect OTs with multispectral images. One is the Water Vapor-InfraRed window channel Brightness Temperature Difference (WV-IRW BTD), which uses the differences in brightness temperatures at an infrared channel (about 11 ㎛). The other approach is the InfraRed Window texture (IRW-texture) method, which is based on the characteristics of OTs that appear a pixel group with low temperatures. The typical IRW-texture algorithm uses simple thresholds to detect OTs, whereas this research proposes an advanced approach based on machine learning techniques such as decision trees, random forest (RF), and support vector machines (SVM) with various variables from geostationary satellite data such as MSG SEVIRI (over Africa) and Himawari AHI (over East Asia) so as to improve the detection of OTs. OT and non-OT samples (e.g. other types of clouds such as stratus and cirrus) were extracted using the CloudSat cloud profiling radar (CPR) and SEVIRI (and Himawari) imagery. Results show that RF produced the best performance in detection of OTs yielding an overall accuracy of 98.33% and a false alarm rate of 9.01%. The user's accuracies of OT and non-OT were similar, whereas the producer's accuracy of non-OT was

  17. The Two-Component System CprRS Senses Cationic Peptides and Triggers Adaptive Resistance in Pseudomonas aeruginosa Independently of ParRS

    DEFF Research Database (Denmark)

    Fernandez, Luca; Jenssen, Håvard; Bains, Manjeet

    2012-01-01

    dependency on the CprRS and ParRS systems in a concentration-dependent manner. It was further demonstrated that, following exposure to inducing antimicrobial peptides, cprRS mutants did not become adaptively resistant to polymyxins as was observed for wild-type cells. Our microarray studies demonstrated...... that the CprRS system controlled a quite modest regulon, indicating that it was quite specific to adaptive peptide resistance. These findings provide greater insight into the complex regulation of LPS modification in Pseudomonas aeruginosa, which involves the participation of at least 4 two-component systems.......Cationic antimicrobial peptides pass across the outer membrane by interacting with negatively charged lipopolysaccharide (LPS), leading to outer membrane permeabilization in a process termed self-promoted uptake. Resistance can be mediated by the addition of positively charged arabinosamine through...

  18. [11C]PR04.MZ, a promising DAT ligand for low concentration imaging: synthesis, efficient 11C-0-methylation and initial small animal PET studies

    Energy Technology Data Exchange (ETDEWEB)

    Riss, P.J.; Hooker, J.; Alexoff, D.; Kim, Sung-Won; Fowler, J.S.; Roesch, F.

    2009-05-01

    PR04.MZ was designed as a highly selective dopamine transporter inhibitor, derived from natural cocaine. Its binding profile indicates that [{sup 11}C]PR04.MZ may be suited as a PET radioligand for the non-invasive exploration of striatal and extrastriatal DAT populations. As a key feature, its structural design facilitates both, labelling with fluorine-18 at its terminally fluorinated butynyl moiety and carbon-11 at its methyl ester function. The present report concerns the efficient [{sup 11}C]MeI mediated synthesis of [{sup 11}C]PR04.MZ from an O-desmethyl precursor trifluoroacetic acid salt with Rb{sub 2}CO{sub 3} in DMF in up to 95 {+-} 5% labelling yield. A preliminary {mu}PET-experiment demonstrates the reversible, highly specific binding of [{sup 11}C]PR04.MZ in the brain of a male Sprague-Dawley rat.

  19. The new 2015 CPR guidelines change and progress%2015心肺复苏指南新变化与进展

    Institute of Scientific and Technical Information of China (English)

    金晓胜; 蔡文伟; 叶侃; 张盖

    2016-01-01

    自从美国 AHA 在1966年发布第一个心肺复苏指南以来,CPR 技术在全球成功抢救了成千上万的心脏骤停患者。经过50多年的发展,CPR 技术已经成为抢救心脏骤停和濒死患者的基本技术之一,对急诊急救产生重大的影响,特别是2000年 CPR 和 ECC 指南的发布:循证医学证据和全球专家的推荐意见成为临床治疗方案的有力支撑。因此,随着研究的进展,每5年更新的指南发布成为医学界关注要点。2015年10月 AHA 在《循环》杂志发布新的心肺复苏指南,新指南流程更加简化,提倡快速反应。将生存链划分为院内和院外,使救治机制更加灵活。确认了单人施救操作顺序,肯定高质量的 BLS 是 ACLS 的坚实基础,并且进一步强调 ACLS 团队合作的重要性。笔者结合2010年版心肺复苏指南基础上对2015年新指南进行比较分析,熟悉和掌握心肺复苏指南新变化,使医务人员更好地掌握 CPR 技术,更加科学、有效地抢救心脏骤停的患者,提高心肺复苏成功率。%Since the United States released the first AHA CPR guidelines in 1966 since,CPR tech-nology in the world successfully rescued tens of thousands of cardiac arrest patients.After 50 years of devel-opment,CPR technology has become one of the dying patient in cardiac arrest and basic rescue techniques, have a significant impact on emergency aid,particularly released in 2000 CPR and ECC guidelines:evi-dence based medicine and global experts The recommendations become a strong support for the clinical treat-ment regimen.Thus,with the progress of the study to update the guidelines every five years,the medical profession has become concerned about the release point.October 2015 AHA in 《Circulation》journal re-leased new CPR guidelines,the new guidelines more streamlined processes,promote rapid response.The chain of survival outside the hospital and into the hospital,so that treatment

  20. A COMPARISON OF INTERNET-BASED LEARNING AND TRADITIONAL CLASSROOM LECTURE TO LEARN CPR FOR CONTINUING MEDICAL EDUCATION

    Directory of Open Access Journals (Sweden)

    Naser HEMMATI

    2013-01-01

    Full Text Available The purpose of this study was to compare the satisfaction and effectiveness of Internet-based learning (IBL and traditional classroom lecture (TCL for continuing medical education (CME programs by comparing final resuscitation exam results of physicians who received the newest cardiopulmonary resuscitation (CPR curriculum guidelines training either by traditional or by an Internet-based CME. A randomized two-group pretest-posttest quasi-experimental design was used. Postgraduate general physician trainees of Iran medical schools were participated. Two methods were compared for teaching the newest curriculum guidelines of the American Heart Association: lecture method in which the teacher follows a Power point presentation with linear layout, and with interactive self-assessment and Scenario-based learning, feedback, multimedia with linear and nonlinear layout with the same power point presentation as lecture in terms of text and photography. The data on final CPR exam grades, collected both groups trained physicians, were obtained for a total of 80 physicians in 2011. An independent sample t-test analysis indicated that participants in the IBL format reported significantly higher mean ratings for this format (62.5 ±2.32 than TCL format (54.6±2.18 (p=.001. There were no significant differences between the two groups in cognitive gains (p<0.05. well-designed IBL content can be effective or a supplement component to CME.

  1. Effectiveness of Play Therapy with CPR (Child-Parent-Relationship approach on reducing Depression and Anxiety in children with cancer

    Directory of Open Access Journals (Sweden)

    Faezeh Sadat Ojagh

    2016-06-01

    Full Text Available Depression and anxiety are known as most common Psychiatric disorders among psychological problems posed by childhood cancer. Depression and anxiety with cancer are risk factors for reduced survival in cancer patients and they are major factors in the rejection therapy. The aim of play therapy is to reduce the depression and anxiety in these children and it improves their mental health status. The study population was children 6 to 11 years that referred to Mahak and Mofid hospitals with cancer diagnosis in 2015. Sampling method was on the available sampling. To select the participants, Child's Behavioral Check List (CBCL was completed by parents and 40 children with cancer that gained more than 69 score in isolation-depression and anxiety-depression scales were randomly assigned to two groups of 20 persons experimental and control groups. The experimental group received 10 sessions of play therapy with CPR approach. CBCL test was conducted to follow up a week before and after the play therapy, and two months after the treatment. Play therapy with child-parent-relationship (CPR approach caused significant reduction in depression in experimental group compare with control group but anxiety reduction between 2 groups was not significant. Results showed that play therapy training to parents of children with cancer caused better compliance with painful treatments and stressful hospital environment.

  2. Prognostic factors for death and survival with or without complications in cardiac arrest patients receiving CPR within 24 hours of anesthesia for emergency surgery

    Directory of Open Access Journals (Sweden)

    Siriphuwanun V

    2014-10-01

    Full Text Available Visith Siriphuwanun,1 Yodying Punjasawadwong,1 Worawut Lapisatepun,1 Somrat Charuluxananan,2 Ketchada Uerpairojkit2 1Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; 2Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Purpose: To determine prognostic factors for death and survival with or without complications in cardiac arrest patients who received cardiopulmonary resuscitation (CPR within 24 hours of receiving anesthesia for emergency surgery. Patients and methods: A retrospective cohort study approved by the Maharaj Nakorn Chiang Mai University Hospital Ethical Committee. Data used were taken from records of 751 cardiac arrest patients who received their first CPR within 24 hours of anesthesia for emergency surgery between January 1, 2003 and October 31, 2011. The reviewed data included patient characteristics, surgical procedures, American Society of Anesthesiologist (ASA physical status classification, anesthesia information, the timing of cardiac arrest, CPR details, and outcomes at 24 hours after CPR. Univariate and polytomous logistic regression analyses were used to determine prognostic factors associated with the outcome variable. P-values of less than 0.05 were considered statistically significant. Results: The outcomes at 24 hours were death (638/751, 85.0%, survival with complications (73/751, 9.7%, and survival without complications (40/751, 5.3%. The prognostic factors associated with death were: age between 13–34 years (OR =3.08, 95% CI =1.03–9.19; ASA physical status three and higher (OR =6.60, 95% CI =2.17–20.13; precardiopulmonary comorbidity (OR =3.28, 95% CI =1.09–9.90; the condition of patients who were on mechanical ventilation prior to receiving anesthesia (OR =4.11, 95% CI =1.17–14.38; surgery in the upper abdominal site (OR =14.64, 95% CI =2.83–75.82; shock prior to cardiac arrest (OR =6.24, 95% CI =2.53–15

  3. 重组大肠杆菌HW2利用甘油高产1,2-丙二醇的研究%Production of 1, 2-propanediol by EngineeringEscherichia ColiHW2 from Glycerol

    Institute of Scientific and Technical Information of China (English)

    何菊; 朱红亮; 胡洪波; 张雪洪

    2015-01-01

    对一株能在厌氧条件下高效代谢甘油的大肠杆菌突变株HW2进行基因工程改造,使其能利用甘油合成1,2-丙二醇。首先,敲除HW2中与丙酮醛脱毒途径相关的三个基因aldA、gloA、hchA和乳酸合成基因ldhA,得到菌株HWAGHL,并在甘油培养基I中厌氧培养。结果显示菌株HWAGHL代谢甘油的能力并没有明显减弱,培养120 h后能产0.013 g⋅L−1的1,2-丙二醇。在HWAGHL中单独过表达mgsA后,经72 h厌氧培养可得0.04 g⋅L−1的1,2-丙二醇,在HWAGHL中共表达gldA、dhaKL(来自弗氏柠檬杆菌)、mgsA和yqhD(HWAGHL/pTH)后,经72 h厌氧培养可得0.48 g⋅L−1的1,2-丙二醇。在菌株HWAGHL/pTH中过表达gldA和fucO,1,2-丙二醇产量可分别提高18%和16%。最后,菌株HWAGHL/pTH在甘油培养基II中厌氧培养,72 h可得1.58 g⋅L−1的1,2-丙二醇,得率为0.20 g⋅g−1甘油。%In previous study, we obtained the engineering strainEscherichia coli HW2 which can dissimilate glycerol effectively in anaerobic conditions. In this paper, an engineering strain based on the strain HW2 was constructed to produce 1, 2-propanediol (1,2-PDO) from glycerol. Firstly, we deleted the genesaldA,gloA and hchA in HW2 to disrupt the detoxification pathway for methylglyoxal, and then we deleted the geneldhA to disrupt the lactate biosynthesis and named the engineering strain as HWAGHL. The strain HWAGHL grows as fast as HW2 in glycerol medium I and produces 0.013 g⋅L−1of 1,2-PDO in 120 h. Moreover, overexpression of the genemgsA in HWAGHL produces 0.04 g⋅L−1of 1,2-PDO in 72 h, while 0.48 g⋅L−1of 1,2-PDO was obtained by co-expression ofgldA,dhaKL (fromCitrobacter freundii),mgsA, andyqhD in HWAGHL(HWAGHL/pTH). In addition, overexpression ofgldA andfucO in the engineering strain HWAGHL/pTH increases the production of 1,2-PDO by 18% and 16%, respectively. Finally, the engineering strain HWAGHL/pTH was anaerobically cultivated in glycerol medium II for 72 h

  4. Manual Cardiopulmonary Resuscitation Versus CPR Including a Mechanical Chest Compression Device in Out-of-Hospital Cardiac Arrest: A Comprehensive Meta-analysis From Randomized and Observational Studies.

    Science.gov (United States)

    Bonnes, Judith L; Brouwer, Marc A; Navarese, Eliano P; Verhaert, Dominique V M; Verheugt, Freek W A; Smeets, Joep L R M; de Boer, Menko-Jan

    2016-03-01

    Mechanical chest compression devices have been developed to facilitate continuous delivery of high-quality cardiopulmonary resuscitation (CPR). Despite promising hemodynamic data, evidence on clinical outcomes remains inconclusive. With the completion of 3 randomized controlled trials, we conduct a meta-analysis on the effect of in-field mechanical versus manual CPR on clinical outcomes after out-of-hospital cardiac arrest. With a systematic search (PubMed, Web of Science, EMBASE, and the Cochrane Libraries), we identified all eligible studies (randomized controlled trials and nonrandomized studies) that compared a CPR strategy including an automated mechanical chest compression device with a strategy of manual CPR only. Outcome variables were survival to hospital admission, survival to discharge, and favorable neurologic outcome. Twenty studies (n=21,363) were analyzed: 5 randomized controlled trials and 15 nonrandomized studies, pooled separately. For survival to admission, the pooled estimate of the randomized controlled trials did not indicate a difference (odds ratio 0.94; 95% confidence interval 0.84 to 1.05; P=.24) between mechanical and manual CPR. In contrast, meta-analysis of nonrandomized studies demonstrated a benefit in favor of mechanical CPR (odds ratio 1.42; 95% confidence interval 1.21 to 1.67; PCPR guidelines (2000 versus 2005) and the CPR strategy (P=.27). Survival to discharge and neurologic outcome did not differ between strategies. Although there are lower-quality, observational data that suggest that mechanical CPR used at the rescuer's discretion could improve survival to hospital admission, the cumulative high-quality randomized evidence does not support a routine strategy of mechanical CPR to improve survival or neurologic outcome. These findings are irrespective of the endorsed CPR guidelines during the study periods. Copyright © 2015 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.

  5. Molecular cloning, bacterial expression and functional characterisation of cytochrome P450 monooxygenase, CYP97C27, and NADPH-cytochrome P450 reductase, CPR I, from Croton stellatopilosus Ohba.

    Science.gov (United States)

    Sintupachee, Siriluk; Ngamrojanavanich, Nattaya; Sitthithaworn, Worapan; De-Eknamkul, Wanchai

    2014-12-01

    The cDNAs for cytochrome P450 monooxygenase (designated as CYP97C27 by D. Nelson's group) and NADPH-cytochrome P450 reductase (designated as CPR I based on its classification) were isolated from Croton stellatopilosus leaves, which actively biosynthesise plaunotol (18-OH geranylgeraniol). CYP97C27 and CPR I contain open reading frames encoding proteins of 471 and 711 amino acids with predicted molecular masses of 53 and 79kDa, respectively. By aligning the deduced sequences of CYP97C27 and CPR I with other plant species, all functional domains of CYP97C27 (heme and oxygen binding) and CPR I (CYP- and FMN, FAD, and NADPH cofactor binding) were identified. Amino acid sequence comparison indicated that both CYP97C27 (85-93%) and CPR I (79-83%) share high sequence identities with homologous proteins in other plant species, suggesting that CYP97C27 belongs to the CYP97C subfamily and that CPR I belongs to class I of the dicotyledonous CPR. Functional characterisation of both enzymes, produced in Escherichia coli (pET32a/BL21(DE3)) as recombinant proteins, showed that simultaneous incubation of CYP97C27 and CPR I with the substrate geranylgeraniol (GGOH) and coenzyme NADPH led to formation of the product plaunotol. In C. stellatopilosus, the levels of the CYP97C27 and CPR I transcripts were highly correlated with those of several mRNAs involved in the plaunotol biosynthetic pathway, suggesting that CYP97C27 and CPR I are the enzymes that catalyse the last hydroxylation step of the pathway.

  6. Oblique collision and deformation partitioning in the SW Iberian Variscides

    Science.gov (United States)

    Pérez-Cáceres, Irene; Simancas, José Fernando; Martínez Poyatos, David; Azor, Antonio; González Lodeiro, Francisco

    2016-05-01

    Different transpressional scenarios have been proposed to relate kinematics and complex deformation patterns. We apply the most suitable of them to the Variscan orogeny in SW Iberia, which is characterized by a number of successive left-lateral transpressional structures developed in the Devonian to Carboniferous period. These structures resulted from the oblique convergence between three continental terranes (Central Iberian Zone, Ossa-Morena Zone and South Portuguese Zone), whose amalgamation gave way to both intense shearing at the suture-like contacts and transpressional deformation of the continental pieces in-between, thus showing strain partitioning in space and time. We have quantified the kinematics of the collisional convergence by using the available data on folding, shearing and faulting patterns, as well as tectonic fabrics and finite strain measurements. Given the uncertainties regarding the data and the boundary conditions modeled, our results must be considered as a semi-quantitative approximation to the issue, though very significant from a regional point of view. The total collisional convergence surpasses 1000 km, most of them corresponding to left-lateral displacement parallel to terrane boundaries. The average vector of convergence is oriented E-W (present-day coordinates), thus reasserting the left-lateral oblique collision in SW Iberia, in contrast with the dextral component that prevailed elsewhere in the Variscan orogen. This particular kinematics of SW Iberia is understood in the context of an Avalonian plate salient currently represented by the South Portuguese Zone.

  7. The Distribution of Water Emission in M17SW

    CERN Document Server

    Snell, R L; Ashby, M L N; Bergin, E A; Chin, G; Erickson, N R; Goldsmith, P F; Harwit, M; Kleiner, S C; Koch, D G; Neufeld, D A; Patten, B M; Plume, R; Schieder, R; Stauffer, J R; Tolls, V; Wang, Z; Winnewisser, G; Zhang, Y F; Melnick, G J

    2000-01-01

    We present a 17-point map of the M17SW cloud core in the 1_{10}-1_{01} transition of ortho-water at 557 GHz obtained with the Submillimeter Wave Astronomy Satellite. Water emission was detected in 11 of the 17 observed positions. The line widths of the water emission vary between 4 and 9 km s^{-1}, and are similar to other emission lines that arise in the M17SW core. A direct comparison is made between the spatial extent of the water emission and the ^{13}CO J = 5\\to4 emission; the good agreement suggests that the water emission arises in the same warm, dense gas as the ^{13}CO emission. A spectrum of the H_2^{18}O line was also obtained at the center position of the cloud core, but no emission was detected. We estimate that the average abundance of ortho-water relative to H_2 within the M17 dense core is approximately 1x10^{-9}, 30 times smaller than the average for the Orion core. Toward the H II region/molecular cloud interface in M17SW the ortho-water abundance may be about 5 times larger than in the dens...

  8. CPR1000、AP1000和EPR控制棒驱动机构及材料差异分析%Differential Analysis among CPR1000 ,AP1000 and EPR Control Rod Drive Mechanism and Material

    Institute of Scientific and Technical Information of China (English)

    兰银辉; 孙广; 尤磊; 邓小云

    2013-01-01

    控制棒驱动机构为核反应堆系统中的重要设备,是一回路压力边界组成部分,起到调节反应堆功率、实现正常停堆和事故工况下紧急停堆的功能.本文介绍了CPR1000、AP1000和EPR控制棒驱动机构在设计参数、结构、材料选用等方面的差异,并分析了这些差异对控制棒驱动机构安全性能的影响.

  9. Research and Development of Performance Test of CPR1000 Rod Control and Rod Position System%CPR1000棒控棒位系统性能试验研究及开发

    Institute of Scientific and Technical Information of China (English)

    赖厚晶; 陈卫华; 姚立民; 钟立军; 李亚坚; 刘琢

    2013-01-01

    落棒试验、控制棒驱动机构(CRDM)性能试验、棒位探测器线性试验是棒控棒位系统3个重要的性能试验.为简化试验步骤、提高准确性,中广核工程有限公司与Rolls-Royce公司联合开发了一套全自动智能化试验设备,对这3个性能试验分别进行了研究,并与大亚湾、岭澳一期的测试设备进行比较.结果表明,CPR1000棒控棒位系统性能试验设备能够快捷、可靠地为调试、运行人员提供试验数据,有效缩短了棒控棒位系统性能试验所需的时间,提高了电站的经济效益.%Rod drop test, control rod drive mechanism(CRDM) performance test and rod position detector linearity test are three of the most important performance tests for rod control and rod position system. In order to simplify the test procedures and improve test accuracy, CNPEC and Rolls-Royce jointly develop a set of intelligent automatic test equipment. The three performance tests are researched and the test equipment used in Daya Bay and ling Ao phase I Nuclear Power Station are compared. The results show that the CPR1000 performance test equipment provides test data to commissioning and operation personnel quickly and reliably. It effectively reduces the time needed in performance test and increases the economic benefit of the nuclear power station.

  10. "Utstein style" spreadsheet and database programs based on Microsoft Excel and Microsoft Access software for CPR data management of in-hospital resuscitation.

    Science.gov (United States)

    Adams, Bruce D; Whitlock, Warren L

    2004-04-01

    In 1997, The American Heart Association in association with representatives of the International Committee on Resuscitation (ILCOR) published recommended guidelines for reviewing, reporting and conducting in-hospital cardiopulmonary resuscitation (CPR) outcomes using the "Utstein style". Using these guidelines, we developed two Microsoft Office based database management programs that may be useful to the resuscitation community. We developed a user-friendly spreadsheet based on MS Office Excel. The user enters patient variables such as name, age, and diagnosis. Then, event resuscitation variables such as time of collapse and CPR team arrival are entered from a "code flow sheet". Finally, outcome variables such as patient condition at different time points are recorded. The program then makes automatic calculations of average response times, survival rates and other important outcome measurements. Also using the Utstein style, we developed a database program based on MS Office Access. To promote free public access to these programs, we established at a website. These programs will help hospitals track, analyze, and present their CPR outcomes data. Clinical CPR researchers might also find the programs useful because they are easily modified and have statistical functions.

  11. Chest Compression Fraction between Mechanical Compressions on a Reducible Stretcher and Manual Compressions on a Standard Stretcher during Transport in Out-of-Hospital Cardiac Arrests: The Ambulance Stretcher Innovation of Asian Cardiopulmonary Resuscitation (ASIA-CPR) Pilot Trial.

    Science.gov (United States)

    Kim, Tae Han; Shin, Sang Do; Song, Kyoung Jun; Hong, Ki Jeong; Ro, Young Sun; Song, Sung Wook; Kim, Chu Hyun

    2017-01-01

    Cardiopulmonary resuscitation (CPR) with the use of mechanical devices is recommended during ambulance transport. However, the CPR quality en route and while in transfer to the emergency department (ED) for out-of-hospital cardiac arrests (OHCAs) remains uncertain. We developed a mechanical CPR device outfitted on a reducible stretcher (M-CPR) and compared with standard manual CPR on a standard stretcher (S-CPR) to evaluate CPR quality. Adult OHCAs transported by five ambulances in a metropolitan area with a population of 3.5 million (many of whom lived in high-rise buildings) from September to October (before-phase) and November to December (after-phase) in 2015 were collected. The reducible stretcher was developed for use in a small elevator during the transfer from scene to ambulance, and the AutoPulse® (ZOLL Medical, Chelmsford, MA, USA) was used for M-CPR. Chest compression fraction (CCF) was measured by transthoracic impedance data using an X-series® cardiac monitor (ZOLL Medical) during time from attachment to patient to arrival to the ED. A comparison of CCF using a Wilcoxon signed-rank test evaluated the difference between the before- and after-phases. Of the eligible 49 OHCAs, 31 (21 in the before-phase and 10 in the after-phase) were analyzed, excluding patients for whom CCF was not measured, for whom M-CPR was not used, who had a return of spontaneous circulation in the field before transport, or who collapsed during transport. There were no differences in demographic data. Median total CCF (median, q1-q3) was significantly higher in the after-phase M-CPR group (85.2, 83.4-86.3) than in the before-phase S-CPR group (80.1, 68.0-85.2) (p = 0.03). Mechanical CPR on the reducible stretcher during the transport of OHCAs to the ED showed a much higher chest compression fraction than standard manual CPR.

  12. First physical volcanological description of a Miocene, silicic, phreatomagmatic fall complex in the Carpatho-Pannonian Region (CPR)

    Science.gov (United States)

    Biró, Tamás; Hencz, Mátyás; Karátson, Dávid; Márton, Emő; Bradák-Hayashi, Balázs; Szalai, Zoltán

    2017-04-01

    The study reports the basic physical volcanological and stratigraphical features of a hitherto unrecognized silicic phreatomagmatic fall succession from the Bükk Foreland Volcanic Area (Hungary), known as part of the extensive Miocene ignimbrite volcanism of the northern CPR. The complex have been identified at two sites, in the vicinity of Bogács and Tibolddaróc villages. Tens of mm to several dm thick layers make up the 20 m thick entire succession. The complex could be subdivided into three eruption cycles by two, intercalated well-developed paleosoil horizons, which indicate longer repose periods. The eruption cycles consist of several individual eruptive events. The volcano-sedimentological field approach was completed by granulometrical and low field anisotropy of magnetic susceptibility (AMS) studies. Combined dry sieving and laser diffraction particle size analysis were performed to get information on median grain size (MdΦ) and sorting (σΦ) of friable layers. AMS was used to infer the emplacement processes. Based on the following features the succession is proposed to record a large-scale, silicic, phreatomagmatic fall activity: i) Presence of very fine ash and abundant ash aggregates, ii) General poor sorting, and often bimodal grain-size distributions; ii) Extremely weak magnetic fabric compared to dilute, thin pyroclastic density current deposits. On the basis of comparison of the recorded grain size characteristics with data from other silicic phretomagmatic fall deposits worldwide, several units in the succession can be considered as phreatoplinian fall deposit (sensu lato), described for the first time in the CPR.

  13. 参加 CPR 培训的心脏性猝死高危者家属对施救陌生人风险认知的质性研究%Risks of high-risk sudden cardiac arrest family members to rescue strangers after CPR training

    Institute of Scientific and Technical Information of China (English)

    薛雪; 王永利; 岳鹏

    2016-01-01

    目的:本研究旨在深入了解参与 CPR 培训的心脏性猝死(SCD)高危者家属对陌生人施救的风险。方法采用半结构式访谈,访谈参加 CPR 培训的 SCD 高危者家属11名,资料分析采用不断比较的方法。结果参与 CPR 培训的 SCD 高危者家属对陌生人施救的风险主要来自:自我能力不足、社会环境堪忧、效果不明确等方面。结论SCD 高危者家属是否会参与 CPR 施救取决于他们对风险的评估和认知。%Objective To investigate the risks of high-risk sudden cardiac death (SCD) family members to rescue strangers after cardiopulmonary resuscitation (CPR)training.Methods A total of 1 1 SCD family members had been semi-structured interviewed.Data was analyzed using constant-comparative method. Results The risks of high-risk SCD family members to rescue strangers included insufficient self-ability, unfavorable social environment and uncertain effects.Conclusions High-risk SCD family members′participation of CPR depends on their knowledge and evaluation of the risks.

  14. Growth Inhibition Effect of DL-Lysine Acetylalicylate on sw480 Colon Carcinoma Cells

    Institute of Scientific and Technical Information of China (English)

    WANG Shu; TIAN Xiao-feng; WANG Li-ming

    2007-01-01

    Objective: To investigate the effect of DL-lysine acetylsalicylate on proliferation of colon carcinoma cells line sw480. Methods: After treatment of DL-lysine acetylsalicylate, the study was performed by observing sw480 colorectal cancer cells with phase contrast microscope, making growth curve, and examining the inhibition rate of sw480 cells with MTT assay. Results: The morphology of sw480 cells showed characteristics of apoptosis, the cell growth curve showed inhibited proliferation of sw480 cells when treated with DL-lysine acetylsalicylate (P<0.05). The rate of inhibition was upward when the drug concentration increased. Conclusion: DL-lysine acetylsalicylate for injection can inhibit the growth of sw480 colorectal cancer cells obviously in a dose dependent manner.

  15. UX Ursae Majoris as a SW Sex star

    Science.gov (United States)

    Neustroev, V. V.; Suleimanov, V. F.; Borisov, N. V.; Belyakov, K. V.; Shearer, A.

    2010-11-01

    We present an analysis of time-resolved, medium resolution optical spectroscopic observations of UX UMa in the blue (3920-5250 A˚) and red (6100-7200 A˚) wavelength ranges in April 1999 and March 2008, respectively. UX UMa has been in different states during those observations. Doppler tomography method was used to accretion disc structure investigation in both states. During the observations in 1999, UX UMa showed many of the defining properties of the SW Sex stars. However, all these features almost completely disappeared in 2008. We have also estimated the radial velocity semi-amplitude K1.

  16. A Unified Electronic Tool for CPR and Emergency Treatment Escalation Plans Improves Communication and Early Collaborative Decision Making for Acute Hospital Admissions.

    Science.gov (United States)

    Johnson, Mae; Whyte, Martin; Loveridge, Robert; Yorke, Richard; Naleem, Shairana

    2017-01-01

    The National Confidential Enquiry into Patient Outcomes and Death (NCEPOD) report 'Time to Intervene' (2012) stated that in a substantial number of cases, resuscitation is attempted when it was thought a 'do not attempt cardiopulmonary resuscitation' (DNACPR) decision should have been in place. Early decisions about CPR status and advance planning about limits of care now form part of national recommendations by the UK Resuscitation Council (2016). Treatment escalation plans (TEP) document what level of treatment intervention would be appropriate if a patient were to become acutely unwell and were not previously formally in place at King's College Hospital. A unifying paper based form was successfully piloted in the Acute Medical Unit, introducing the TEP and bringing together decision making around both treatment escalation and CPR status. Subsequently an electronic order-set for CPR status and treatment escalation was launched in April 2015 which led to a highly visible CPR and escalation status banner on the main screen at the top of the patient's electronic record. Ultimately due to further iterations in the electronic process by December 2016, all escalation decisions for acutely admitted patients now have high quality supporting, explanatory documentation with 100% having TEPs in place. There is now widespread multidisciplinary engagement in the process of defining limits of care for acutely admitted medical patients within the first 14 hours of admission and a strategy for rolling this process out across all the divisions of the hospital through our Deteriorating Patient Group (DPG). The collaborative design with acute medical, palliative and intensive care teams and the high visibility provided by the electronic process in the Electronic Patient Record (EPR) has enhanced communication with these teams, patients, nursing staff and the multidisciplinary team by ensuring clarity through a universally understood process about escalation and CPR. Clarity and

  17. CPR 1000技术核电机组高频振动故障诊断与处理%Fault Diagnosis and Processing on High Frequency Vibration of CPR1000 Nuclear Power Unit

    Institute of Scientific and Technical Information of China (English)

    杨毅; 高庆水; 张楚; 刘石; 杜胜磊; 李力

    2016-01-01

    针对 CPR1000技术半转速核电机组汽轮机在调试期间出现瓦振超标,存在大比例振动幅值波动的高频成分,通过大修前振动试验、大修中模态测试、高频激振力来源辨识等试验分析,判断该机组瓦振高频振动故障是3号进汽管道内的不稳定汽流激振力经进汽管道、汽缸传递至轴承箱引发轴承箱盖不稳定共振所致。根据振动故障诊断分析结果,通过优化调节汽门的开启程序和方式,改变管道内汽流的状态参数,使得瓦振大幅降低至优良水平;从阻隔高频激振力的传递路径、瓦振测点位置选择等方面对机组瓦振安全性进行评估,并提出了改进方案。%In allusion to the problem of superstandard bearing vibration of steam turbine of CPR1000 half-speed nuclear pow-er unit in commissioning period which may cause high frequency with high range vibration amplitude fluctuation,experimen-tal analysis on vibration experiment before overhaul,mode testing in overhaul,identification on high frequency exciting force source,and so on is carried out to judge reason for high frequency vibration fault of the unit bearing vibration is un-steady resonance of bearing box cover caused by unsteady steam exciting force in No.3 steam pipe flowing through steam pipe and cylinder stator to the bearing box.According to fault diagnosis analysis results,it is proved to be able to greatly re-duce bearing vibration to fine level by optimizing open program and mode of steam regulating valve and changing state pa-rameters of gas flow in the pipe.In terms of transferring path of obstructing high frequency exciting force and selection for testing point position of bearing vibration,security of unit bearing vibration is evaluated and improvement scheme is pro-posed.

  18. Stabilization of pSW100 from Pantoea stewartii by the F conjugation system.

    Science.gov (United States)

    Lin, Mei-Hui; Liu, Shih-Tung

    2008-05-01

    Plasmid pSW100 is 1 of the 13 plasmids from Pantoea stewartii subsp. stewartii SW2 which has a replicon that resembles that of ColE1. This work uses a pSW100 derivative, pSW140K, to study how the pSW100 replicon is stably maintained in its hosts. Our results indicate that although pSW140K is stable in Escherichia coli HB101, the plasmid is rapidly lost in another E. coli strain, DH5alpha, indicating that the genetic background of an E. coli strain affects the stability of pSW140K. Mutagenesis of E. coli HB101 with EZ::TN revealed that mutations in traC, traF, traG, traN, and traV, which encode the components of the sex pilus assembly, reduce plasmid stability. Furthermore, this work identified that a 38-bp region located immediately upstream of the RNAII promoter is critical to the maintenance of plasmid stability in E. coli HB101. TraC binds to the region, and in addition, deleting the region destabilizes the plasmid. Furthermore, inserting this 38-bp fragment into a plasmid that contains the minimal replicon from pSW200 stabilizes the plasmid in E. coli HB101. Fluorescence in situ hybridization and immunofluorescence staining also revealed that derivatives of pSW100, pSW128A, and TraC are colocalized in cells, suggesting that pSW100 may use the sex pilus assembly as a partition apparatus to ensure the even distribution of the plasmid during cell division, which may thus maintain the plasmid's stability.

  19. Improvement of ethanol productivity and energy efficiency by degradation of inhibitors using recombinant Zymomonas mobilis (pHW20a-fdh).

    Science.gov (United States)

    Dong, Hong-Wei; Fan, Li-Qiang; Luo, Zichen; Zhong, Jian-Jiang; Ryu, Dewey D Y; Bao, Jie

    2013-09-01

    Toxic compounds, such as formic acid, furfural, and hydroxymethylfurfural (HMF) generated during pretreatment of corn stover (CS) at high temperature and low pH, inhibit growth of Zymomonas mobilis and lower the conversion efficiency of CS to biofuel and other products. The inhibition of toxic compounds is considered as one of the major technical barriers in the lignocellulose bioconversion. In order to detoxify and/or degrade these toxic compounds by the model ethanologenic strain Z. mobilis itself in situ the fermentation medium, we constructed a recombinant Z. mobilis ZM4 (pHW20a-fdh) strain that is capable of degrading toxic inhibitor, formate. This is accomplished by cloning heterologous formate dehydrogenase gene (fdh) from Saccharomyces cerevisiae and by coupling this reaction of NADH regeneration reaction system with furfural and HMF degradation in the recombinant Z. mobilis strain. The NADH regeneration reaction also improved both the energy efficiency and cell physiological activity of the recombinant organism, which were definitely confirmed by the improved cell growth, ethanol yield, and ethanol productivity during fermentation with CS hydrolysate.

  20. The impact of ultra-brief chest compression-only CPR video training on responsiveness, compression rate, and hands-off time interval among bystanders in a shopping mall.

    Science.gov (United States)

    Panchal, Ashish R; Meziab, Omar; Stolz, Uwe; Anderson, Wes; Bartlett, Mitchell; Spaite, Daniel W; Bobrow, Bentley J; Kern, Karl B

    2014-09-01

    Recent studies have demonstrated higher-quality chest compressions (CCs) following a 60 s ultra-brief video (UBV) on compression-only CPR (CO-CPR). However, the effectiveness of UBVs as a CPR-teaching tool for lay bystanders in public venues remains unknown. Determine whether an UBV is effective in teaching laypersons CO-CPR in a public setting and if viewing leads to superior responsiveness and CPR skills. Adult lay bystanders were enrolled in a public shopping mall and randomized to: (1) Control (CTR): sat idle for 60 s; (2) UBV: watched a 60 s UBV on CO-CPR. Subjects were read a scenario detailing a sudden collapse in the mall and asked to do what they "thought was best" on a mannequin. Performance measures were recorded for 2 min: responsiveness (time to call 911 and first CCs) and CPR quality [CC depth, rate, hands-off interval (time without CC after first CC)]. One hundred subjects were enrolled. Demographics were similar between groups. UBV subjects called 911 more frequently (percent difference: 31%) and initiated CCs sooner in the arrest scenario (median difference (MD): 5 s). UBV cohort had increased CC rate (MD: 19 cpm) and decreased hands-off interval (MD: 27 s). There was no difference in CC depth. Bystanders with UBV training in a shopping mall had significantly improved responsiveness, CC rate, and decreased hands-off interval. Given the short length of training, UBV may have potential as a ubiquitous intervention for public venues to help improve bystander reaction to arrest and CO-CPR performance. Published by Elsevier Ireland Ltd.

  1. Seismic structure of the main geological provinces off the SW Iberian margin: first results from the NEAREST-SEIS wide-angle seismic survey

    Science.gov (United States)

    Sallarès, Valentí; Martínez-Loriente, Sara; Gailler, Audrey; Bartolomé, Rafael; Gutscher, Marc-André; Graindorge, David; Lia Grácia, Eulà; Díaz, Jordi

    2010-05-01

    The region offshore the SW Iberian margin hosts the present-day NW-SE plate convergence between the European and African Plates at a rate of 4.5 mm/yr, fact that causes continuous seismic activity of moderate magnitude. In autumn 2008 a Spanish-French team carried out a refraction and wide-angle reflection seismic survey in the area (NEAREST-SEIS cruise), in the framework of the EU, FP6-funded NEAREST project. During the survey two long seismic profiles were acquired using a pool of 36 Ocean Bottom Seismometers (OBS), with the objectives of providing information about the geometry of the crust-mantle boundary and the physical properties of the crust, revealing the deep geometry of the main fault interfaces, and identifying the nature of the basement and the limits of the different geological provinces in the region. A total of 30 OBS were deployed along profile P1, which is 356 km long and trends NW-SE from the Tagus abyssal plain (TAP), crossing the Gorringe bank (GB), the Horseshoe abyssal plain (HAP) and the Coral Patch Ridge (CPR), up to the thrust-and-fold belt of the Seine abyssal plain (SAP). The acquired data were modeled by joint refraction and reflection travel time inversion, following a layer-stripping strategy. The inverted model show four well-differentiated domains in terms of its seismic structure: In the TAP a 3-4 km-thick, low velocity sedimentary layer covers the basement, which shows a remarkably high velocity (>7 km/s), similar to that of the basement outcropping in the Gorringe bank. In the HAP the sedimentary cover is thicker, showing an upper unit with low velocity corresponding to the Horseshoe gravitational unit, on top of a higher velocity lower unit, which may represent the highly consolidated Mesozoic sedimentary sequence. The thickness of the two units together exceeds 5 km. The basement shows the same velocity distribution as in TAP and GB, suggesting a common nature and origin. According to its seismic structure, and considering that

  2. Seismic structure and crustal nature of the geological provinces off the SW Iberian margin: results of the NEAREST-SEIS wide-angle seismic survey

    Science.gov (United States)

    Sallares, V.; Martinez, S.; Gailler, A.; Gutscher, M.; Bartolome, R.; Gracia, E.; Diaz, J.

    2010-12-01

    The region offshore the SW Iberian margin hosts the present-day NW-SE plate convergence between the European and African Plates causing continuous seismic activity of moderate magnitude. In autumn 2008 a Spanish-French team carried out a wide-angle seismic survey in the area (NEAREST-SEIS cruise), in the framework of the EU-funded NEAREST project. During the survey two long profiles were acquired using a pool of 36 Ocean Bottom Seismometers (OBS), to provide information about the crustal structure and nature of the different geological provinces, and to reveal the deep geometry of the main fault interfaces. A total of 30 OBS were deployed along profile P1, which is 356 km long and trends NW-SE from the Tagus abyssal plain (TAP), crossing the Gorringe bank (GB), the Horseshoe abyssal plain (HAP) and the Coral Patch Ridge (CPR), up to the thrust-and-fold belt of the Seine abyssal plain (SAP). The inverted model along this profile show four different domains. In the TAP a 3-4 km-thick, low velocity sedimentary layer covers the basement, which shows a velocity >7 km/s just 2-3 km below its top, similarly to that of the basement outcropping in the Gorringe bank. In the HAP the sedimentary cover is thicker, showing an upper unit with low velocity corresponding to the Horseshoe gravitational unit, on top of a higher velocity lower unit, which may represent the highly consolidated Mesozoic sedimentary sequence, with a total thickness of 5 km. The basement shows the same velocity distribution as in TAP and GB, suggesting a common nature and origin. According to its seismic structure, we interpret this basement as highly serpentinized, exhumed mantle. In contrast, the CPR and SAP show evidences for the presence of a well-developed, 6-7 km-thick oceanic crust, underlying the sedimentary sequence. Profile P2 is 256 km long, and trends S-N from the easternmost SAP beyond the NW Moroccan margin, crossing the Gulf of Cadiz imbricated wedge and the Portimao bank ending at the

  3. Early detection of brain death using the Bispectral Index (BIS) in patients treated by extracorporeal cardiopulmonary resuscitation (E-CPR) for refractory cardiac arrest.

    Science.gov (United States)

    Jouffroy, Romain; Lamhaut, Lionel; Guyard, Alexandra; Philippe, Pascal; An, Kim; Spaulding, Christian; Baud, Frédéric; Carli, Pierre; Vivien, Benoît

    2017-08-24

    Despite increasing use of extracorporeal cardiopulmonary resuscitation (E-CPR) for treatment of refractory cardiac arrest patients, prognosis remains dismal, often resulting in brain-death. However, clinical assessment of brain-death occurence is difficult in post-cardiac arrest patients, sedated, paralyzed, under mild therapeutic hypothermia (MTH). Our objective was to assess the usefulness of Bispectral-Index (BIS) monitoring at bedside for an early detection of brain-death occurrence in refractory cardiac arrest patients treated by E-CPR. This prospective study was performed in an intensive care unit of an university hospital. Forty-six patients suffering from refractory cardiac arrest treated by E-CPR were included. BIS was continuously recorded during ICU hospitalization. Clinical brain-death was confirmed when appropriate by EEG and/or cerebral CT angiography. Twenty-nine patients evolved into brain-death and had average BIS values under MTH and after rewarming (temperature ≥35°C) of 4 (0-47) and 0 (0-82), respectively. Among these, 11 (38%) entered into a procedure of organs donation. Among the 17 non-brain-dead patients, the average BIS values at admission and after rewarming were 39 (0-65) and 59 (22-82), respectively. Two patients had on admission a BIS value equal to zero and evolved to a poor prognostic (CPC 4) and died after care limitations. BIS values were significantly different between patients who developed brain death and those who did not. In both groups, no differences were observed between the AUCs of ROC curves for BIS values under MTH and after rewarming (respectively 0.86 vs 0.83, NS). Initial values of BIS could be used as an assessment tool for early detection of brain-death in refractory cardiac arrest patients treated by mild therapeutic hypothermia and E-CPR. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. A ventilation technique for oxygenation and carbon dioxide elimination in CPR: Continuous insufflation of oxygen at three levels of pressure in a pig model.

    Science.gov (United States)

    Ordelman, Simone C M A; Aelen, Paul; Woerlee, Pierre H; van Berkom, Paul F J; Scheffer, Gert-Jan; Noordergraaf, Gerrit J

    2015-12-01

    Pulmonary ventilation remains an important part of cardiopulmonary resuscitation, affecting gas exchange and haemodynamics. We designed and studied an improved method of ventilation for CPR, constructed specifically to support both gas exchange and haemodynamics. This method uses continuous insufflation of oxygen at three levels of pressure, resulting in tri-level pressure ventilation (TLPV). We hypothesized that TLPV improves gas exchange and haemodynamics compared to manual gold standard ventilation (GSV). In 14 pigs, ventricular fibrillation was induced and automated CPR performed for 10 min with either TLPV or GSV. After defibrillation, CPR was repeated with the other ventilation method. Gas exchange and haemodynamics were monitored. Data are presented as mean±standard error of the mean. TLPV was superior to GSV for PaO2 (163±36 mmHg difference; P=0.001), and peak AWP (-20±2 cmH2O difference; P=0.000) and higher for mean AWP (8±0.2 cmH2O difference; P=0.000). TLPV was comparable to GSV for CPP (5±3 mmHg difference; P=0.012), VCO2 (0.07±0.3 mL/min/kg difference; P=0.001), SvO2 (4±3%-point; P=0.001), mean carotid flow (-0.5±4 mL/min difference; P=0.016), and pHa (0.00±0.03 difference; P=0.002). The PaCO2 data do not provide a conclusive result (4±4 mmHg difference). We conclude that the ventilation strategy with a tri-level pressure cycle performs comparable to an expert, manual ventilator in an automated-CPR swine model. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  5. Pyrethroid-resistance is modulated by miR-92a by targeting CpCPR4 in Culex pipiens pallens.

    Science.gov (United States)

    Ma, Kai; Li, Xixi; Hu, Hongxia; Zhou, Dan; Sun, Yan; Ma, Lei; Zhu, Changliang; Shen, Bo

    2017-01-01

    The wide use of pyrethroids has resulted in the emergence and spread of resistance in mosquito populations, which represent a major obstacle in the struggle against vector-borne diseases. Resistance to pyrethroids is a complex genetic phenomenon attributed by polygenetic inheritance. We previously have sequenced and analyzed the miRNA profiles of Culex pipiens pallens. MiR-92a was found to be overexpressed in a deltamethrin-resistant (DR) strain. The association of miR-92a with pyrethroid-resistance was investigated by quantitative reverse transcription PCR (qRT-PCR). Expression levels of miR-92a were 2.72-fold higher in the DR strain than in the deltamethrin-susceptible (DS) strain. Bioinformatic analysis suggested that CpCPR4, a mosquito cuticle gene, is the target of miR-92a. Dual luciferase reporter assays further confirmed that CpCPR4 is modulated by miR-92a through binding to a specific target site in the 3' untranslated region (3' UTR). Microinjection of the miR-92a inhibitor upregulated CpCPR4 expression levels, leading to an increase in the susceptibility of the DR strain in the Centers for Disease Control and Prevention (CDC) bottle bioassay (a surveillance tool for detecting resistance to insecticides in vector populations). Taken together, our findings indicate that miR-92a regulates pyrethroid-resistance through its interaction with CpCPR4. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Structural and functional basis of transcriptional regulation by TetR family protein CprB from S. coelicolor A3(2)

    OpenAIRE

    Bhukya, Hussain; Bhujbalrao, Ruchika; Bitra, Aruna; Anand, Ruchi

    2014-01-01

    Antibiotic production and resistance pathways in Streptomyces are dictated by the interplay of transcriptional regulatory proteins that trigger downstream responses via binding to small diffusible molecules. To decipher the mode of DNA binding and the associated allosteric mechanism in the sub-class of transcription factors that are induced by γ-butyrolactones, we present the crystal structure of CprB in complex with the consensus DNA element to a resolution of 3.25 Å. Binding of the DNA resu...

  7. Estudio comparativo de la productividad y calidad obtenidas en la soldadura de tubos de calidad T9 empleados en el sector petroquímico, mediante los procesos TIG, HW-TIG y PAW Comparative study of productivity and quality obtained in tube welding quality T9 employees in the petrochemical industry, through TIG, HW-TIG and PAW processes

    Directory of Open Access Journals (Sweden)

    César García González

    2012-09-01

    Full Text Available Tradicionalmente, la fabricación soldada de tuberías de acero Cr-Mo empleadas en serpentines de hornos para la industria petroquímica se ha venido realizando de forma masiva mediante procesos de baja productividad, principalmente TIG para la pasada de raíz y SMAW para las pasadas de relleno, ambos manuales. En este estudio se muestran los resultados de la investigación realizada por el Centro Tecnológico AIMEN, en relación al empleo de tecnologías de alto rendimiento, concretamente TIG, HW-TIG y PAW robotizadas, aplicadas a los mismos materiales y productos. De este modo se calculan y comparan cuatro índices de productividad: Tiempo de Soldadura, Tasa de Deposición, Material Depositado y Volumen de Gas Consumido. El objetivo del estudio es contribuir a la reducción de los tiempos de producción, de los costes de fabricación, y a la mejora de la calidad del producto.Traditionally, the manufacture of welded Cr-Mo steel pipes used in furnace coils for petrochemical industry has been carried out on a massive scale by low productivity processes, mainly TIG for root pass and SMAW for layers of filling run, both of them manuals. This study presents the results of a research, conducted by AIMEN Technology Centre, related to the use of high performance technologies, specifically robotic processes such as TIG, TIG-HW and PAW, applied to the same materials and products. Thus, four productivity ratios have been calculated and compared: welding time, deposition rate, deposited material and volume of consumed gas. The aim of the study is to contribute to the reduction of the production time, manufacturing costs and to the improvement of the product quality.

  8. Active NE-SW Compressional Strain Within the Arabian Plate

    Science.gov (United States)

    Floyd, M. A.; ArRajehi, A.; King, R. W.; McClusky, S.; Reilinger, R. E.; Douad, M.; Sholan, J.; Bou-Rabee, F.

    2012-12-01

    Motion of the Arabian plate with respect to Eurasia has been remarkably steady over more than 25 Myr as revealed by comparison of geodetic and plate tectonic reconstructions (e.g., McQuarrie et al., 2003, GRL; ArRajehi et al., 2010, Tectonics). While internal plate deformation is small in comparison to the rate of Arabia-Eurasia convergence, the improved resolution of GPS observations indicate ~ NE-SW compressional strain that appears to affect much of the plate south of latitude ~ 30°N. Seven ~ NE-SW oriented inter-station baselines all indicated shortening at rates in the range of 0.5-2 mm/yr, for the most part with 1-sigma velocity uncertainties < 0.4 mm/yr. Plate-scale strain rates exceed 2×10-9/yr. The spatial distribution of strain can not be resolved from the sparse available data, but strain appears to extend at least to Riyadh, KSA, ~ 600 km west of the Zagros Fold and Thrust Belt that forms the eastern, collisional boundary of the Arabian plate with Eurasia (Iran). Geodetic velocities in the plate tectonic reference frame for Arabia, derived from magnetic anomalies in the Red Sea (Chu and Gordon, 1998, GJI), show no significant E-W motion for GPS stations located along the Red Sea coast (i.e., geodetic and plate tectonic spreading rates across the Red Sea agree within their resolution), in contrast to sites in the plate interior and along the east side of the plate that indicate east-directed motions. In addition, NE-SW contraction is roughly normal to ~ N-S striking major structural folds in the sedimentary rocks within the Arabian Platform. These relationships suggest that geodetically observed contraction has characterized the plate for at least the past ~ 3 Myr. Broad-scale contraction of the Arabian plate seems intuitively reasonable given that the east and north sides of the plate are dominated by active continental collision (Zagros, E Turkey/Caucasus) while the west and south sides are bordered by mid-ocean ridge spreading (Red Sea and Gulf of

  9. Long-term retrospective analysis of mackerel spawning in the North Sea: a new time series and modeling approach to CPR data.

    Science.gov (United States)

    Jansen, Teunis; Kristensen, Kasper; Payne, Mark; Edwards, Martin; Schrum, Corinna; Pitois, Sophie

    2012-01-01

    We present a unique view of mackerel (Scomber scombrus) in the North Sea based on a new time series of larvae caught by the Continuous Plankton Recorder (CPR) survey from 1948-2005, covering the period both before and after the collapse of the North Sea stock. Hydrographic backtrack modelling suggested that the effect of advection is very limited between spawning and larvae capture in the CPR survey. Using a statistical technique not previously applied to CPR data, we then generated a larval index that accounts for both catchability as well as spatial and temporal autocorrelation. The resulting time series documents the significant decrease of spawning from before 1970 to recent depleted levels. Spatial distributions of the larvae, and thus the spawning area, showed a shift from early to recent decades, suggesting that the central North Sea is no longer as important as the areas further west and south. These results provide a consistent and unique perspective on the dynamics of mackerel in this region and can potentially resolve many of the unresolved questions about this stock.

  10. Long-term retrospective analysis of mackerel spawning in the North Sea: a new time series and modeling approach to CPR data.

    Directory of Open Access Journals (Sweden)

    Teunis Jansen

    Full Text Available We present a unique view of mackerel (Scomber scombrus in the North Sea based on a new time series of larvae caught by the Continuous Plankton Recorder (CPR survey from 1948-2005, covering the period both before and after the collapse of the North Sea stock. Hydrographic backtrack modelling suggested that the effect of advection is very limited between spawning and larvae capture in the CPR survey. Using a statistical technique not previously applied to CPR data, we then generated a larval index that accounts for both catchability as well as spatial and temporal autocorrelation. The resulting time series documents the significant decrease of spawning from before 1970 to recent depleted levels. Spatial distributions of the larvae, and thus the spawning area, showed a shift from early to recent decades, suggesting that the central North Sea is no longer as important as the areas further west and south. These results provide a consistent and unique perspective on the dynamics of mackerel in this region and can potentially resolve many of the unresolved questions about this stock.

  11. Classroom-Level Positive Behavior Supports in Schools Implementing SW-PBIS: Identifying Areas for Enhancement

    Science.gov (United States)

    Reinke, Wendy M.; Herman, Keith C.; Stormont, Melissa

    2013-01-01

    This study evaluated the use of classroom-level behavior management strategies that align with School-Wide Positive Behavioral Interventions and Supports (SW-PBIS). Direct observations of universal classroom management strategies were conducted across 33 elementary classrooms in elementary schools implementing SW-PBIS with high fidelity. Findings…

  12. Testing the Kerr nature of black hole candidates using iron line reverberation mapping in the CPR framework

    CERN Document Server

    Jiang, Jiachen; Steiner, James F

    2016-01-01

    The iron K$\\alpha$ line commonly observed in the X-ray spectrum of black hole candidates is produced by X-ray fluorescence of the inner accretion disk. This line can potentially be quite a powerful tool to probe the spacetime geometry around these objects and test the Kerr black hole hypothesis. In a previous paper, we studied the ability to constrain possible deviations from the Kerr solution from the standard time-integrated iron line spectrum within the Cardoso-Pani-Rico framework. In the present work, we expand on that study and consider iron line reverberation mapping in the CPR framework. That is, we consider the time-evolution of the iron line profile in response to fluctuations in the X-ray primary source. Our simulations clearly show that the time information in reverberation mapping can better constrain the background metric than the time-integrated approach, and this is true, notably, for the deformation parameter $\\epsilon^r_3$, which is only weakly informed by a time-integrated observation.

  13. Numerical simulation of magneto-acoustic Wave Phase Conjugation with the DG method in the CPR framework

    Science.gov (United States)

    Modarreszadeh, Seyedamirreza; Timofeev, Evgeny; Merlen, Alain; Matar, Olivier Bou; Pernod, Philippe

    2017-07-01

    The present paper is concerned with the numerical modeling of magneto-acoustic Wave Phase Conjugation (WPC) phenomena. Since ultrasonic waves in the WPC applications have short wavelengths relative to the traveling distances, high-order numerical methods in both space and time domains are required. The numerical scheme chosen for the current research is the Runge-Kutta Discontinuous Galerkin (RKDG) method incorporated into the Correction Procedure via Reconstruction (CPR) framework. In order to avoid non-physical oscillations near high-gradient regions, a Weighted Essentially Non-Oscillatory (WENO) limiter is used to reconstruct the solutions in the affected cells. After being assured that the numerical scheme has appropriate accuracy and performance, the WPC process is modeled in both linear and non-linear regimes. The results in the linear regime are in acceptable agreement with the analytical solution. The only significant deviation between the linear and non-linear results is at the sensor within the passive zone, where the mean pressure starts to grow gradually in the non-linear regime due to overtaking of the low-velocity pressure waves by the high-velocity ones.

  14. Fluorescence quenching studies of γ-butyrolactone binding protein (CprB) from Streptomyces coelicolor A3(2).

    Science.gov (United States)

    Biswas, Anwesha; Swarnkar, Ravi K; Hussain, Bhukya; Sahoo, Suraj K; Pradeepkumar, P I; Patwari, G Naresh; Anand, Ruchi

    2014-08-28

    Quorum sensing is a cell density dependent phenomenon that utilizes small molecule inducers like γ-butyrolactones (GBLs) and their receptor proteins for adaptation to the environment. The cognate GBLs that bind to several of this GBL receptor family of proteins remain elusive. Here, using CprB protein from Streptomyces coelicolor A3(2) as a model system, we devise a method suited for ligand screening that would be applicable to the entire family of GBL receptors. Docking studies were performed to confirm the identity of the ligand binding pocket, and it was ascertained that the common γ-butyrolactone moiety interacts with the conserved tryptophan residue (W127) residing in the ligand binding pocket. The presence of W127 in the cavity was exploited to monitor its fluorescence quenching on the addition of two chemically synthesized GBLs. Analysis of the data with both the native and W185L mutant versions of the protein confirmed that the compounds used as quenchers reside in the ligand binding pocket. Furthermore, fluorescence lifetime and potassium iodide (KI) quenching studies established that the quenching is static in nature and that the tryptophan residue is buried and inaccessible to surface quenchers. Additionally, a combination of concentration dependent fluorescence quenching and dynamic light scattering experiments revealed that the binding properties of the protein are concentration dependent and it was concluded that the most efficient binding of the ligand is evoked by working at the lowest concentration of protein, providing a sufficient signal, where the aggregation effects are negligible.

  15. Geochemistry of Archaean supracrustal belts in SW Greenland

    DEFF Research Database (Denmark)

    Szilas, Kristoffer

    . (3) The Nunatak 1390 area contains ultramafic rocks with geochemical characteristics similar to high-Ti komatiites, but they show geochemical signs of a juvenile slab melt contribution. Their high MgO contents may thus reflect flux-melting of a refractory mantle source, as is the case for boninites......This PhD-thesis investigates the geological formation environment of c. 3200-3000 million-year-old volcanic rocks from SW Greenland, using whole-rock geochemical data in combination with U-Pb, Sm-Nd and Lu-Hf isotope data. The following three supracrustal areas were studied: (1) The Tartoq Group...... geochemical mixing trends between juvenile felsic and mafic end-members. This suggests that partial melting and magma mixing by mafic underplating and slab melt metasomatism of the mantle source region were important in forming rocks of andesitic composition, which is also observed in some modern island arcs...

  16. Speleological exploration results for Kamena Gora and Petnja, SW Serbia

    Directory of Open Access Journals (Sweden)

    Nešić Dragan

    2011-01-01

    Full Text Available Speleomorphological exploration in the Kamena Gora village area and Petnja depression, parts of the Jabuka-Babine plateau bordering on Montenegro in the extreme SW of Serbia, is described in this paper in the sections on morphology, survey methods and general speleomorphologic and morphogenetic features of caves. The results of particular note are the two cave systems in Petnja depression: the Petnja Caves 551 m long and the Kurtova Jama system 650 m long, the latter probably being one of major speleologic features in Serbia. The big and small Mujova Caves and Bezdan are the three caves explored in Kamena Gora. The exploration should be continued at a general survey level.

  17. Changes in heat waves characteristics over Extremadura (SW Spain): duration, intensity and frequency

    Science.gov (United States)

    Acero, Javier; Parey, Sylvie; Fernández-Fernández, María Isabel; Carrasco, Víctor Manuel; Agustín García, José

    2016-04-01

    Heat waves (HW) are increasing and its consequences are important not only for the effects over the population but also for the agriculture and biodiversity. That's why trends in heat wave events over Extremadura, a Region located in the southwest of Spain and characterized by irrigated land with crops like corn or tomatoes growing in summers, has been studied. Heat waves are defined as days occurring above the 95th percentile of the summer (June-August) maximum temperature time series. Another event named as Warm Event (WE) has been studied and defined as exceedance over the 75th percentile. For this purpose, a set of 13 regularly distributed daily maximum temperature time series was selected from a larger database for the Region of Extremadura for the common period 1965-2014. A stochastic seasonal functional heteroscedastic auto-regressive model developed to simulate daily (minimum, maximum, or mean) temperature time series coherent with observed time series (Parey et al., 2014, Dacunha-Castelle et al., 2015) has been used. This stochastic temperature generator is used to reproduce 1000 time series equivalent to the observed ones in order to investigate the significance of the changes in HW characteristics: duration, intensity and frequency; using different sub-periods length for the observed period. The results show that the changes in HW frequencies of the last 10-year sub-period comparing to the first are significant for 7 of the 13 observatories but the changes in HW durations and intensities are not significant. But when considering the lower threshold (75th percentile) to study changes in WE characteristics, frequency shows significant changes in 8 observatories, duration for 4 observatories and intensity for 2. Then, the parameters of the WE are increasing higher than the corresponding to the HW events. References: Parey, S., T. T. H. Hoang, and D. Dacunha-Castelle (2014), Validation of a stochastic temperature generator focusing on extremes, and an

  18. Establishing a new Archaeomagnetic Record for the SW Pacific

    Science.gov (United States)

    Stark, F.; Cassidy, J.; Gratton, M. N.; Hill, M. J.; Shaw, J.; Sheppard, P. J.

    2008-12-01

    The goal of this study is to establish the first archaeomagnetic record for the SW Pacific for the last few millennia using an outstanding collection of well-dated archaeological ceramics from a wide region, namely: 1. Bismarks-Northern Solomons 3500-0 BP, 2. Western Solomons 2000-0 BP, 3. Southeast Solomons 3100- 2000 BP, 4. Vanuatu 3100-700 BP, 5. New Caledonia 3000-0 BP, 5. Fiji -Tonga 3000-0 BP. Ultimately, we aim to investigate the potential for archaeomagnetic dating, especially of un-orientated inter-tidal samples that have proved impossible to date using C14 methods because of their disturbed contexts. Because the currently available samples are un-orientated, we are using palaeointensity measurements to establish the archaeomagnetic record. Although much archaeomagnetic intensity data (especially of the last three millennia) are already available, the geographic distribution of sites is very poor with a particular lack of data for the southern hemisphere. The new data will be the first such from the SW Pacific and should therefore contribute significantly to improving global field models. Preliminary measurements of palaeointensity from samples from the W-Solomon (site New Georgia, 3100 BP) and SE-Solomon (site Santa Cruz, 600 BP) Islands show a mean value of 33.4 ± 5.4 μT and 31.6 ± 4.2 μT, respectively. In addition we will present further results, primarily from Lakeba in Fiji (18.2° S, 178.8° E) and the Duke of York Islands in the Bismarck Archipelago (4.2° S, 152.5° E). Palaeointensity measurements are being carried out using the latest state of the art microwave demagnetisation methods in order to minimise alteration. We use pTRM and tail-checks in order to detect any thermo-chemical alteration and multi domain (MD) effects. Anisotropy and cooling rate are also determined and corrected for.

  19. The Tomato spotted wilt virus cell-to-cell movement protein (NSM) triggers a hypersensitive response in Sw-5 containing resistant tomato lines and Nicotiana benthamiana transformed with the functional Sw-5b resistance gene copy.

    NARCIS (Netherlands)

    Hallwass, M.; Silva de Oliveira, A.; Dianese, E.C.; Lohuis, D.; Boiteux, L.S.; Inoue-Nagata, A.K.; Resende, de R.O.; Kormelink, R.J.M.

    2014-01-01

    Although the Sw-5 gene cluster has been cloned, and Sw-5b has been identified as the functional gene copy that confers resistance to Tomato spotted wilt virus (TSWV), its avirulence (Avr) determinant has not been identified to date. Nicotiana tabacum SR1 plants transformed with a copy of the Sw-5b

  20. Three-Dimensional Shallow Water Adaptive Hydraulics (ADH-SW3): Turbulence Closure

    Science.gov (United States)

    2015-06-01

    ER D C/ CH L CR -1 5- 1 Three- Dimensional Shallow Water Adaptive Hydraulics (ADH-SW3): Turbulence Closure Co as ta l a nd H yd ra ul ic...library at http://acwc.sdp.sirsi.net/client/default. ERDC/CHL CR-15-1 June 2015 Three- Dimensional Shallow Water Adaptive Hydraulics (ADH-SW3...closure schemes into the three- dimensional shallow water module of the Adaptive Hydraulics (ADH-SW3) numerical code. The report also briefly

  1. Travel time seismic tomography on Reykjanes, SW Iceland

    Science.gov (United States)

    Jousset, Philippe; Ágústsson, Kristjan; Blanck, Hanna; Metz, Malte; Franke, Steven; Pàll Hersir, Gylfi; Bruhn, David; Flovenz, Ólafur; Friðleifsson, Guðmundur

    2017-04-01

    We present updated tomographic results obtained using seismic data recorded around geothermal reservoirs located both on-land Reykjanes, SW-Iceland and offshore along Reykjanes Ridge. We gathered records from a network of 234 seismic stations (including 24 Ocean Bottom Seismometers) deployed between April 2014 and August 2015. In order to determine the orientation of the OBS stations, we used Rayleigh waves planar particle motions from large magnitude earthquakes. This method proved suitable using the on-land stations: orientations determined using this method with the orientations measured using a giro-compass agreed. We focus on the 3D velocity images using local earthquakes to perform travel time tomography. The processing includes first arrival picking of P- and S- phases using an automatic detection and picking technique based on Akaike Information Criteria. We locate earthquakes by using a non-linear localization technique, as a priori information for deriving a 1D velocity model. We then computed 3D velocity model by joint inversion of each earthquake's location and velocity lateral anomalies with respect to the 1D model. Our models confirms previous models obtained in the area, with enhanced details. In a second step, we performed inversion of the Vp/Vs ratio. Results indicate a low Vp/Vs ratio anomaly at depth suggesting the absence of large magmatic body under Reykjanes, unlike results obtained at other geothermal field, sucha as Krafla and Hengill. We discuss implications of those results in the light of recent IDDP drilling in Reykjanes.

  2. Palaeoenvironmental reconstruction of Hüsamlar coal seam, SW Turkey

    Indian Academy of Sciences (India)

    Zeynep Büçkün; HüLya İnaner; Riza Görkem Oskay; Kimon Christanis

    2015-06-01

    The Ören and Yatağan Basins in SW Turkey host several Miocene coal deposits currently under exploitation for power generation. The present study aims to provide insight into the palaeoenvironmental conditions, which controlled the formation of the Hüsamlar coal seam located in Ören Basin. The coal seam displays many sharp alternations of matrix lignite beds and inorganic, lacustrine sediment layers. The coal is a medium-to-high ash lignite (10.47–31.16 wt%, on dry basis) with high total sulphur content (up to 10 wt%, on dry, ash-free basis), which makes it prone to self-combustion. The maceral composition indicates that the peat-forming vegetation consisted of both arboreal and herbaceous plants, with the latter being predominant in the upper part of the seam. Mica and feldspars contribute to the low part of the seam; carbonates are dominant in the upper part, whereas quartz and pyrite are present along the entire coal profile. The sudden transitions of the telmatic to the lacustrine regime and reverse is attributed to tectonic movements that controlled water table levels in the palaeomire, which affected surface runoff and hence, clastic deposition.

  3. ROLE OF PANCREATIC STELLATE CELLS AND GALECTIN-3 ON PROLIFERATION AND INFILTRATION OF HUMAN PANCREATIC CANCER CELL LINE SW1990

    Institute of Scientific and Technical Information of China (English)

    JIANG Hai-biao; XU Ming; WANG Xing-peng

    2008-01-01

    Objective To investigate the role of pancreatic stellate cells (PSCs) and galectin-3 (GAL-3)on the proliferation and infiltration of pancreatic cancer cell line SW1990. Methods Human pancreatic cancercell line SW1990 and PSCs were cultured in vitro. Supernatant of cultured PSCs and SW1990 cells was collected.Expressions of GAL-3 in SW1990 cells and PSCs were detected by ELISA, RT-PCR and Western blot. Theproliferation of those cultured PSCs and SW1990 cells were measured by MTT assay and flowcytometry. Infiltrationof SW1990 cells was detected by cell infiltration kit. Results SW1990 cells expressed GAL-3 and the expressionwas up-regulated by the supernatant fluid of cultured PSCs. PSCs did not express GAL-3. SW1990 cells couldstimulate the proliferation of PSCs via GAL-3. GAL-3 antibody could inhibit SW1990 cells proliferation andinfiltration, which indicated that supernatant of PSCs might stimulate the proliferation of SW1990 cells through theinteraction with GAL-3 protein. The supernatant fluid of PSCs could enhance the invasiveness of SW1990 cellsthrough the interaction with GAL-3. Conclusion GAL-3 and PSCs was involved in the proliferation andinfiltration process of pancreatic cancer.

  4. Study on Invasion of Artesunate on Inhibiting Human Colon Cancer Cell SW620

    Directory of Open Access Journals (Sweden)

    Yu Fan

    2013-09-01

    Full Text Available Objective: To observe the invasive effect of Chinese extraction artesunate on human colon cancer cell SW620 and explore its possible mechanisms. Methods: Colon cancer cell SW620 was managed by different concentrations of artesunate, and soft agar colony-cultivating trial was applied to detect anchorage independent proliferation of cancer cells, Boyden chamber model method to detect the invasive capability of cancer cells and Western blot method to detect the change of intercellular adhesion molecule-1 (ICAM-1 proteins. Results: Artesunate can effectively inhibit malignant proliferation and invasive capability of colon cancer cell SW620, and was dose-dependent (P < 0.01. Artesunate can effectively inhibit the expression of cancer cell ICAM-1 gene proteins, and was time- and concentration-dependant (P <0.01. Conclusion: Artesunate can significantly inhibit the invasion of colon cancer cell SW620, which can be related to down-regulation of ICAM-1 protein level.

  5. Study on Invasion of Artesunate on Inhibiting Human Colon Cancer Cell SW620

    Institute of Scientific and Technical Information of China (English)

    Fan Yu; Zhang Youli; Yao Guangtao; Li Yikui

    2013-01-01

    Objective:To observe the invasive effect of Chinese extraction artesunate on human colon cancer cell SW620 and explore its possible mechanisms. Methods:Colon cancer cell SW620 was managed by different concentrations of artesunate, and soft agar colony-cultivating trial was applied to detect anchorage independent proliferation of cancer cells, Boyden chamber model method to detect the invasive capability of cancer cells and Western blot method to detect the change of intercellular adhesion molecule-1 (ICAM-1) proteins. Results:Artesunate can effectively inhibit malignant proliferation and invasive capability of colon cancer cell SW620, and was dose-dependent (P Conclusion:Artesunate can signiifcantly inhibit the invasion of colon cancer cell SW620, which can be related to down-regulation of ICAM-1 protein level.

  6. Amphibians and agrochemicals: Dermal contact and pesticide uptake from irrigated croplands in SW Georgia

    Science.gov (United States)

    Background/Question/Methods Although isolated wetlands comprise a significant portion of amphibian breeding habitats throughout the United States, they are not protected under the Clean Water Act. In SW Georgia where agriculture is dominant within the landscape, many isolated ...

  7. Production of uracil from methane by a newly isolated Methylomonas sp. SW1.

    Science.gov (United States)

    Kim, Sangwoo; Lee, Wangjun; Song, Insu; Kwon, Yuhyun; Yun, Seokhun; Park, Soohyun; Cho, Sukhyeong; Oh, Byung-Keun; Oh, Han Bin; Lee, Jinwon

    2016-12-20

    Methane is an abundant, inexpensive one-carbon feedstock and one of the most powerful greenhouse gases. Because it does not compete with food demand, it is considered a promising carbon feedstock for the production of valuable products using methanotrophic bacteria. Here, we isolated a novel methanotrophic bacterium, Methylomonas sp. SW1, from a sewage sample obtained from Wonju City Water Supply Drainage Center, Republic of Korea. The conditions for uracil production by Methylomonas sp. SW1, such as Cu(2+) concentration and temperature were investigated and optimized. As a result, Methylomonas sp. SW1 produced uracil from methane as a sole carbon source with a titer of 2.1mg/L in 84h without genetic engineering under the optimized condition. The results in this study demonstrate the feasibility of using Methylomonas sp. SW1 for the production of uracil from methane. This is the first report of uracil production from gas feedstock by methanotrophic bacteria.

  8. Use of a checklist during observation of a simulated cardiac arrest scenario does not improve time to CPR and defibrillation over observation alone for subsequent scenarios.

    Science.gov (United States)

    Dilley, Stuart J; Weiland, Tracey J; O'Brien, Robert; Cunningham, Neil J; Van Dijk, Julian E; Mahoney, Rosie M; Williams, Matthew J

    2015-01-01

    Immersive simulation is a common mode of education for medical students. Observation of clinical simulations prior to participation is believed to be beneficial, though this is often a passive process. Active observation may be more beneficial. The hypothesis tested in this study was that the active use of a simple checklist during observation of an immersive simulation would result in better participant performance in a subsequent scenario compared with passive observation alone. Medical students were randomized to either passive or active (with checklist) observation of an immersive simulation involving cardiac arrest prior to participating in their own simulation. Performance measures included time to cardiopulmonary resuscitation (CPR) and time to defibrillation and were compared between first and second scenarios as well as between passive and active observers. Seventy-nine simulations involving 232 students were conducted. Mean time to CPR was 18 seconds (SD = 11.6) for those using the checklist and 24 seconds (SD = 15.8) for those who observed passively (M difference = 6 seconds), t(35) = 1.46, p =.153. Time to defibrillation was 94 seconds (SD = 26.4) for those using the checklist and 92 seconds (SD = 23.8) for those who observed passively (M difference = -2 seconds), t(38) =.21, p =.837. Time to CPR was 24 seconds (SD = 15.8) for passive observers and 31 seconds (SD = 21.0; M difference = 7 seconds), t(35) = 1.13, p =.265, for their first scenario counterparts. Time to CPR was 18 seconds (SD = 11.6) for active observers and 36 seconds (SD = 26.2; M difference = 18 seconds), t(24) = 2.81, p =.010, for their first scenario counterparts. Time to defibrillation was 92 seconds (SD = 23.8) for passive observers and 125 seconds (SD = 32.2; M difference = 33 seconds), t(33) = 3.63, p =.001, for their first scenario counterparts. Time to defibrillation was 94 seconds (SD = 26.4) for the active observers and 132 seconds (SD = 52.9; M difference = 38 seconds), t(28

  9. Magnetostratigraphy of the Neogene sediments of SW Uruguay

    Science.gov (United States)

    Sanchez Bettucci, L.; Orgeira, M. J.; Sanchez, G.; Bertoni-Machado, C.; Farina, R.

    2007-05-01

    Preliminary results on the magnetostratigraphy of three Neogene formations from SW Uruguay are presented: Camacho, Raigón and Libertad, and a relative age from the record of reversions in the Earth's magnetic field polarity is proposed. The sediments outcrop in the SW region of Uruguay,and have been received attention due to their fossil contents. The oldest is the late Miocene-Pliocene Camacho Fm, of Huayquerian to Montehermosan affinities. A Pliocene-early Pleistocene age has been assigned to Raigón Fm, of Chapadmalalan affinities. The overlying Libertad Fm has been considered early-middle Pleistocene in age, and to have Marplatan-Ensenadan affinities. The lithology of this facies of Camacho Fm is identified by the presence of fine to very fine sandstones and is composed of silty-sandy and bioturbed silty deposits. The marine facies of this formation is rich in fossil content, as several invertebrate and vertebrate taxa are found. The upper Raigón Fm is formed by sandstones of varied grain size and includes lenses and levels of claystones and conglomerates. It shows the sedimentological features of a deep, pebble-rich braided fluvial system. The 383 vertebrate specimens found in the sandy facies and studied in a taphonomically-oriented study belong to 19 genera and 13 higher taxa. The bones are disarticulated, with smooth fractures and little weathered or abraded, which is congruent with a short time of contact, as observed in strong and sudden flows. The elements belong to the three Voorhies groups and fractured specimens are found along with well preserved materials, implying different taphonomical histories and reworking. The consequent inferred time averaging urges caution at using these remains for defining precise ages. The Libertad Fm, top of the sequence, is conformed by greenish clays, clayey fine sandstones, medium sized sandstones and conglomeratic levels, corresponding to deposits of continental origin under a semiarid climate, which allowed the

  10. Tamarugite from Diana Cave (SW Romania) -first true karst occurrence

    Science.gov (United States)

    Pušcaš, C. M.; Onac, B. P.; Effenberger, H. S.; Povarǎ, I.

    2012-04-01

    Diana Cave is located within the town limits of Baile Herculane (SW Romania) and develops as a 14 m long, westward oriented, unique passage guided by the Diana fault [1]. At the far end of the cave, the thermo-mineral Diana Spring wells forth. In the early 1970s a mine gallery that intersected the cave was created to drain the water into a pumping station and the original cave passage was somewhat altered and reinforced with concrete. Today the concrete and the silty limestone cave walls are heavily corroded by H2SO4 outgassing from the hot water (ca. 50°C) and display abundant gypsum crusts, soggy aggregates of native S, and a variety of more exotic sulfates. Among them, a mineral that has been previously identified in caves only in connection to volcanic activity, either as thermal springs or fumaroles [2]: tamarugite [NaAl(SO4)26H2O]. It was [3] that first mentioned the occurrence of this Na and Al sulfate in Diana Cave, our research aiming to give a detailed description of this mineral, its paragenesis, and mechanisms of precipitation. Recently, tamarugite has also been identified in a sulfuric acid cave from Greece [4]. Along with powder X-ray diffractions coupled with Rietveld refinement, scanning electron microscope, and electron probe micro-analysis, δ18O and δ34S compositions of the sulfate mineral as well as precipitates from the water were analyzed to identify and better constrain the genesis of this rare sulfate. Regrettably, the crystal size of our specimens is inappropriate for identification by means of single crystal X-ray diffraction. Physical and chemical parameters of Diana Spring were as well measured on several occasions. Geochemical analysis suggests that the minute, white tamarugite flakes precipitated in Diana Cave as a result of the interactions between the thermo-mineral water or water vapor and the original limestone bedrock and concrete that blankets the mine gallery. [1] Povara, I., Diaconu, G., Goran, C. (1972). Observations pr

  11. Sea urchins, their predators and prey in SW Portugal

    Directory of Open Access Journals (Sweden)

    Nuno Mamede

    2014-06-01

    Full Text Available Sea urchins play a key role structuring benthic communities of rocky shores through an intense herbivory. The most abundant sea urchin species on shallow rocky subtidal habitats of the SW coast of Portugal is Paracentrotus lividus (Echinodermata: Echinoidea. It is considered a key species in various locations throughout its geographical distribution by affecting the structure of macroalgae communities and may cause the abrupt transformation of habitats dominated by foliose algae to habitats dominated by encrusting algae - the urchin barrens. The removal of P. lividus predators by recreational and commercial fishing is considered a major cause of this phenomenon by affecting the trophic relationships between predators, sea urchins and algae communities. Marine protected areas (MPAs usually lead to the recovery of important predator species that control sea urchin populations and restore habitats dominated by foliose macroalgae. Therefore, MPAs provide a good opportunity to test cascading effects and indirect impacts of fishing at the ecosystem level. The ecological role of P. lividus was studied on rocky subtidal habitats of the SW coast of Portugal (Alentejo considering three trophic levels: population of P. lividus, their predators (fish and shellfish and their prey (macroalgae communities. Several studies were conducted: (1 a non-destructive observational study on the abundance and distribution patterns of P. lividus, their predators and preys, comparing areas with different protection; (2 a manipulative in situ study with cages to assess the role of P. lividus as an herbivore and the influence of predation; (3 a descriptive study of P. lividus predators based on underwater filming; (4 and a study of human perception on these trophic relationships and other issues on sea urchin ecology and fishery, based on surveys made to fishermen and divers. Subtidal studies were performed with SCUBA diving at 3-12 m deep. Results indicate that in the

  12. Paleoclimatic records from holocene speleothems of SW Angola

    Science.gov (United States)

    Mayer, A.; Claude, C.; Stenni, B.

    2003-04-01

    Here we report the first results of a paleoclimatic study using O- and U-Th isotopes on a stalactite from the Tchivinguiro cave (Chela Formation, SW Angola). TIMS U-Th age determinations on 10 fragments were carried-out. The stalactite rim returned an age of 4930+/-50 y, dating an interruption of calcite deposition, possibly due to the onset of a drier period. Layering in the stalactite has an average thickness of 6.4 mm. Assuming that the layers are annual, the stalactite potentially records environmental conditions from 5 to 18 ka. Further age determinations are in progress. A δ18O profile on individual layers corresponding to a time interval of 25 y centred at 6.6 ka was obtained with an ionprobe Cameca IMS 1270 in Nancy. δ18O ranges from +24.5 to +29.1 (SMOW) with an average δ18O = +26.8. The average calculated δ18O of the water from which the speleothems deposited is -3.3 assuming today annual mean temperature of the cave (18.4^oC). The measured δ18O of today water in the cave is -5.5, similar to the annual mean of the rain collected in the area during this study. To explain the difference of -2.2 δ18O units, a cooler period during calcite deposition is invoked. Assuming 13^oC as a minimum local temperature (at LGM), the δ18O of the water in equilibrium with the stalactite is -4.6. A combination of changes in moisture sources, trajectory path and local effects may explain the lighter value of the water in the cave at 6.6 ka relative to today.

  13. Southwest Indian Ocean Bathymetric Compilation (swIOBC)

    Science.gov (United States)

    Jensen, L.; Dorschel, B.; Arndt, J. E.; Jokat, W.

    2014-12-01

    As result of long-term scientific activities in the southwest Indian Ocean, an extensive amount of swath bathymetric data has accumulated in the AWI database. Using this data as a backbone, supplemented by additional bathymetric data sets and predicted bathymetry, we generate a comprehensive regional bathymetric data compilation for the southwest Indian Ocean. A high resolution bathymetric chart of this region will support geological and climate research: Identification of current-induced seabed structures will help modelling oceanic currents and, thus, provide proxy information about the paleo-climate. Analysis of the sediment distribution will contribute to reconstruct the erosional history of Eastern Africa. The aim of swIOBC is to produce a homogeneous and seamless bathymetric grid with an associated meta-database and a corresponding map for the area from 5° to 39° S and 20° to 44° E. Recently, multibeam data with a track length of approximately 86,000 km are held in-house. In combination with external echosounding data this allows for the generation of a regional grid, significantly improving the existing, mostly satellite altimetry derived, bathymetric models. The collected data sets are heterogeneous in terms of age, acquisition system, background data, resolution, accuracy, and documentation. As a consequence, the production of a bathymetric grid requires special techniques and algorithms, which were already developed for the IBCAO (Jakobsson et al., 2012) and further refined for the IBCSO (Arndt et al., 2013). The new regional southwest Indian Ocean chart will be created based on these methods. Arndt, J.E., et al., 2013. The International Bathymetric Chart of the Southern Ocean (IBCSO) Version 1.0—A new bathymetric compilation covering circum-Antarctic waters. GRL 40, 1-7, doi: 10.1002/grl.50413, 2013. Jakobsson, M., et al., 2012. The International Bathymetric Chart of the Arctic Ocean (IBCAO) Version 3.0. GRL 39, L12609, doi: 10.1029/2012GL052219.

  14. Stratigraphy of the Krš Gradac section (SW Serbia

    Directory of Open Access Journals (Sweden)

    Radoičić Rajka

    2009-01-01

    Full Text Available In the Krš Gradac section (near to Sjenica, SW Serbia, a transition of a carbonate platform to basin facies are outcropped: Norian-lower Liassic shallow-water carbonates, middle Liassic-lower Dogger Ammonitico Rosso facies, and upper Bathonian into lowermost Cretaceous deep-water radiolarites in which the carbonate graded bed and mass flow layer are intercalated. The presence of a lower Dogger condensed sequence with the Bajocian protoglobigerinid event was hitherto not evidenced. It is documented that components of a graded bed are of extrabasinal (upper Triassic-lower Tithonian carbonate platform sediments and intrabasinal (radiolarite, meta-andesite origin, indicating a tectonic event not older than the early Tithonian. This tectonic event caused the fracturing of the carbonate platform, also partly basinal area. Consequently, the age of the graded bed is not older than the lower Tithonian. In the uppermost radiolaritic sediments in the Krš Gradac section (?middle-upper Tithonian-lowermost Cretaceous, a mass flow layer appears, which contains clasts of intrabasinal origin - different radiolarites, siliceous radiolarian argillites (some of which are unconsolidated with washed radiolarians and sponge spicules in a ferruginous sediment, sandstone grains, etc. The mass flow event is estimated as Berriasian. In the Krš Gradac radiolarite succession, the authors recognized two deep-water formations, an older one, upper Bathonian-lower Tithonian, between hardground (Dogger and a graded bed, and a younger formation, which started with a graded bed. This formation, according to its stratigraphic position, corresponds to ?middle-upper Tithonian-lowermost Cretaceous.

  15. Determination of Teloschistes flavicans (sw norm anti-inflammatory activity

    Directory of Open Access Journals (Sweden)

    Eugênia C Pereira

    2010-01-01

    Full Text Available Background: Lichens produce a variety of substances that possesses pharmacological actions. However, rare products are submitted to rigorous scientific tests or have the risk potential or side effects evaluated. The lack of medical and sanitary control, absence of accurate botanical identification or purity certification, founded in diverse natural products, may represent great danger to population health. This work aimed to evaluate toxic effects and anti-inflammatory action in vivo of Teloschistes flavicans (Sw. Norm. (TFN unrefined extracts, as well as determinate its main constituents. Methods: The carrageenan induced paw edema and cotton pellet implant induced granuloma methods were utilized, besides a classic acute toxicity test. TFN acetone extract inhibited carrageenan paw edema on 60, 120, and 180 min (inhibition percentiles of 45.03%, 60.59% and 41.72%. Results: TFN ethereal (inhibition percentiles of 23.95% and 29.01% and chloroform (inhibition percentiles of 28.8% and 22.04% extracts inhibited edema on 120 and 180 min. None of the extract inhibited the granuloma development. None of the extract caused death or other acute toxicity signs. Vicanicine (60.26% in ethereal extract and 51.17% in acetone extract, parietine (9.60% in ethereal extract and 15.38% on second, falacinol (0.78% in ether and 14.95% in acetone and very low concentration of falacinal (0.15% in ethereal extract and 3.32% in acetone extract were detected in the medicine. Conclusions: The tested extracts have antiedematogenic activity, but are not effective on subchronic inflammation. The extracts do not present toxic effects in administered doses.

  16. ORCA: the versatile CPR

    NARCIS (Netherlands)

    A.M. van Ginneken (Astrid); H. Stam (Hendrik); E.M. van Mulligen (Erik); M. de Wilde (Marcel); J.H. van Bemmel (Jan); R. van Mastrigt (Robbert)

    2000-01-01

    textabstractThe introduction of computer-based patient records (CPRs) that fully replace paper records proves especially difficult in specialized care, despite the potential advantages of CPRs for patient care and research. Improved data legibility, availability, sharing of records, and decision sup

  17. ORCA: the versatile CPR

    NARCIS (Netherlands)

    A.M. van Ginneken (Astrid); H. Stam (Hendrik); E.M. van Mulligen (Erik); M. de Wilde (Marcel); J.H. van Bemmel (Jan); R. van Mastrigt (Robbert)

    2000-01-01

    textabstractThe introduction of computer-based patient records (CPRs) that fully replace paper records proves especially difficult in specialized care, despite the potential advantages of CPRs for patient care and research. Improved data legibility, availability, sharing of records, and decision

  18. CPR1000全厂断电叠加蒸汽发生器安全阀误开启事故引起的严重事故分析%Analysis of CPR1000 Severe Accident Induced by SBO With SG Safety Valve Stuck Open

    Institute of Scientific and Technical Information of China (English)

    李龙泽; 王明军; 田文喜; 苏光辉; 秋穗正

    2014-01-01

    The CPR1000 severe accident caused by station blackout (SBO) with the SG safety valve stuck open was modeled and analyzed using MELCOR code ,and the simula-tion of CPR1000 severe accident process was preliminarily achieved . Three assump-tions ,namely without shaft sealing leakage and auxiliary feed water ,with shaft sealing leakage and auxiliary feed water ,and with shaft sealing leakage but without auxiliary feed water ,were analyzed .The results imply that SG safety valve stuck open has great influence on the accident sequences .According to the calculation results ,without shaft sealing leakage and auxiliary feed water ,pressure vessel will fail at 9 576 s .When auxil-iary feed water supplies ,pressure vessel failure delays nearly 30 000 s .When the leak-age of the shaft sealing system exists ,pressure vessel failure will delay about 50 s .The results show that the auxiliary feed water and the leakage of the shaft sealing system have great mitigation effect on the severe accident induced by SBO with SG safety valve stuck open .%利用MELCOR程序对CPR1000全厂断电叠加蒸汽发生器(SG)安全阀误开启事故引发的严重事故进行建模与分析,初步实现了对CPR1000严重事故进程的仿真计算与模拟。文中重点分析了无轴封泄漏和辅助给水、有轴封泄漏和辅助给水、有轴封泄漏但无辅助给水3种不同假设条件下CPR1000全厂断电严重事故的响应进程和结果。计算结果显示,SG安全阀误开启对事故进程有重要影响。在无轴封泄漏和辅助给水的情况下,压力容器在9576 s失效;当存在辅助给水时,压力容器失效延后近30000 s;而当存在轴封泄漏时,压力容器失效延后50 s左右。结果证明了发生全场断电叠加SG安全阀误开启事故情况下辅助给水和轴封泄漏对事故起到有效缓解作用。

  19. Functional expression of a putative geraniol 8-hydroxylase by reconstitution of bacterially expressed plant CYP76F45 and NADPH-cytochrome P450 reductase CPR I from Croton stellatopilosus Ohba.

    Science.gov (United States)

    Sintupachee, Siriluk; Promden, Worrawat; Ngamrojanavanich, Nattaya; Sitthithaworn, Worapan; De-Eknamkul, Wanchai

    2015-10-01

    While attempting to isolate the enzyme geranylgeraniol 18-hydroxylase, which is involved in plaunotol biosynthesis in Croton stellatopilosus (Cs), the cDNAs for a cytochrome P450 monooxygenase(designated as CYP76F45) and an NADPH-cytochrome P450 reductase (designated as CPR I based on its classification) were isolated from the leaf. The CYP76F45 and CsCPR I genes have open reading frames (ORFs) encoding 507- and 711-amino acid proteins with predicted relative molecular weights of 56.7 and 79.0 kDa,respectively. Amino acid sequence comparison showed that both CYP76F45 (63–73%) and CsCPR I (79–83%) share relatively high sequence identities with homologous proteins in other plant species.Phylogenetic tree analysis confirmed that CYP76F45 belongs to the CYP76 family and that CsCPR I belongs to Class I of dicotyledonous CPRs, with both being closely related to Ricinus communis genes. Functional characterization of both enzymes, each expressed separately in Escherichia coli as recombinant proteins,showed that only simultaneous incubation of the membrane bound proteins with the substrate geraniol (GOH) and the coenzyme NADPH could form 8-hydroxygeraniol. The enzyme mixture could also utilize acyclic sesquiterpene farnesol (FOH) with a comparable substrate preference ratio (GOH:FOH) of 54:46. The levelsof the CYP76F45 and CsCPR I transcripts in the shoots, leaves and twigs of C. stellatopilosus were correlated with the levels of a major monoterpenoid indole alkaloid, identified tentatively as 19-Evallesamine,that accumulated in these plant parts. These results suggested that CYP76F45 and CPR I function as the enzyme geraniol-8-hydroxylase (G8H), which is likely to be involved in the biosynthesis of the indole alkaloid in C. stellatopilosus [corrected].

  20. Intercomparison of Vertical Structure of Storms Revealed by Ground-Based (NMQ and Spaceborne Radars (CloudSat-CPR and TRMM-PR

    Directory of Open Access Journals (Sweden)

    Veronica M. Fall

    2013-01-01

    Full Text Available Spaceborne radars provide great opportunities to investigate the vertical structure of clouds and precipitation. Two typical spaceborne radars for such a study are the W-band Cloud Profiling Radar (CPR and Ku-band Precipitation Radar (PR, which are onboard NASA’s CloudSat and TRMM satellites, respectively. Compared to S-band ground-based radars, they have distinct scattering characteristics for different hydrometeors in clouds and precipitation. The combination of spaceborne and ground-based radar observations can help in the identification of hydrometeors and improve the radar-based quantitative precipitation estimation (QPE. This study analyzes the vertical structure of the 18 January, 2009 storm using data from the CloudSat CPR, TRMM PR, and a NEXRAD-based National Mosaic and Multisensor QPE (NMQ system. Microphysics above, within, and below the melting layer are studied through an intercomparison of multifrequency measurements. Hydrometeors’ type and their radar scattering characteristics are analyzed. Additionally, the study of the vertical profile of reflectivity (VPR reveals the brightband properties in the cold-season precipitation and its effect on the radar-based QPE. In all, the joint analysis of spaceborne and ground-based radar data increases the understanding of the vertical structure of storm systems and provides a good insight into the microphysical modeling for weather forecasts.

  1. Molecular cloning, expression of CPR gene from Rhizopus oryzae into Rhizopus nigericans and its application in the 11α-hydroxylation of 16α, 17-epoxy-progesterone.

    Science.gov (United States)

    Chen, Xiaolong; Luo, Xinrong; Cao, Feifei; Zhu, Tingheng; Fan, Yongxian; Jia, Xiaoqing; Shen, Yinchu

    2014-11-01

    The hydroxylations of the steroid skeleton structure are catalyzed by a family of enzymes, the cytochromes P450 (CYPs). In this study, the pCB1004-PgpdA plasmid was used for cloning the cytochrome P450 reductase (CPR) gene from Rhizopus oryzae into Rhizopus nigericans to strengthen the expression of CPR gene in R. nigericans with REMI (Restriction Enzyme Mediate Integration) mediated protoplast transformation. The conditions for the protoplast production of R. nigericans were optimized as follows: 75 μg/mL yatalase, 50 μg/mL lywallzyme, fungus age of 12h, digestion time of 3 h and digestion temperature of 30°C. REMI mediated protoplast transformation with plasmid pCB1004-PgpdA into R. nigericans was performed to construct the transformants. More than 30 transformants were successfully selected from the hygromycin B-resistant plates and 6 transformants had the abilities to improve the biotransformation of 16α, 17-epoxyprogesterone. The highest biotransformation rate of the transformants was 65.38%, which was 7.06% higher than that of the original strain.

  2. Crustal nature and seismic structure of the geological provinces offshore the SW Iberia: Highlights of the NEAREST-SEIS wide-angle seismic survey

    Science.gov (United States)

    Martínez-Loriente, S.; Sallares, V.; Gailler, A.; Bartolome, R.; Gracia, E.; Gutscher, M.; Diaz, J.

    2011-12-01

    The SW Iberian margin hosts the present day NW-SE plate convergence between the European and African Plates at a rate of 4.5 mm/yr causing seismic activity of moderate magnitude. During fall 2008 and in the frame of the EU-funded NEAREST project, was carried out a wide-angle seismic survey (NEAREST-SEIS cruise) consisting in 2 profiles. The main objectives of the survey were to gather information about the geometry of the crust-mantle boundary, identify the nature of the different geological provinces, obtain the physical properties of the crust, and unveil the deep geometry of the interfaces between main faults. A total of 30 OBS were deployed along profile P1, which is 356 km long and trends NW-SE running from the Tagus Abyssal Plain (TAP), Gorringe Bank (GB), Horseshoe Abyssal Plain (HAP), Coral Patch Ridge (CPR), and finally reaching the thrust-and-fold belt of the Seine Abyssal Plain (SAP). The inverted model shows four well-differentiated domains in terms of seismic structure. In the TAP there is a 3-4 km-thick sediment layer with low velocity, lying above a basement showing a remarkably high velocity (< 7 km/s), similar to that of the basement outcropping in the GB. In the HAP the sedimentary cover is thicker, showing an uppermost unit with very low velocity corresponding to the Upper Miocene Horseshoe Gravitational Unit, on top of a higher velocity lower unit, which corresponds to the Mesozoic sedimentary sequence, with a total thickness of 5 km. The basement shows the same velocity distribution as in TAP and GB, suggesting a common nature and origin. According to its seismic structure, we interpret this basement as very serpentinized, exhumed upper mantle. In contrast, the CPR and SAP show evidence for the presence of a well-developed, 6-7 km-thick oceanic crust, underlying the 2-3 km thick Mesozoic and Neogene sedimentary sequence. Profile P2 is 256 km long and trends N-S, across the Iberian margin shelf, Portimao Bank, Gulf of Cadiz imbricated wedge and

  3. Isolation of Side Population Cells and Detection of ABCG2 from SW480

    Institute of Scientific and Technical Information of China (English)

    LIU Hai-guang; PAN Yi-fei; GUO Gui-long; HU Xiao-qu; HUANG Ka-te; ZHANG Xiao-hua

    2007-01-01

    Objective: Side population cells (SP cells) are a new type of stem cells. They mainly express ABCG2/BCRP1 and have the ability to eliminate DNA dye Hoechst33342. Many studies showed that side population cells were able of self-renewal, differentiation and carcinogenesis in cancers. Our investigation aimed at isolation of side population cells and ABCG2 positive subpopulation from colon cancer cell line SW480 and identification of their characteristics of cancer stem cells. Methods: side population cells and non-side population cells of colon cancer cell line SW480 were isolated with DNA dye Hoechst33342 and their cell cycles were measured by flow cytometry. Expression of ABCG2 of SW480 was measured by immunohistochemistry and immunofluorescence, and its proportion was measured by flow cytometry. Results: SW480 contained 2.29% side population cells. The fraction of side population cells decreased greatly to 0.40% by treatment with verapamil. The fraction of side population cells in S-G2M cell cycle was 16.14%, which was much lower than the fraction (34.05%) of non-side population cells in S-G2M. In SW480, ABCG2 positive cells, which proportion was 9.66%, were small, circular or oval, lack of psuedopods, similar to poor differentiation. On the contrary, the ABCG2 negative cells were large, polygonal, with many psuedopods, similar to high differentiation. Conclusion: our assay identified that side population cells did exist in SW480 and had a quiescence characteristic of stem cells. ABCG2 positive subpopulation occupied about 9.66% of SW480 and may have the ability to promote cell self-renewal and inhibit cell differentiation. Therefore, to isolate ABCG2 positive subpopulation from side population cells may be an alternative to study colorectal cancer stem cells.

  4. Geochemical evolution of lithospheric mantle underlying Intrasudetic Fault (SW Poland).

    Science.gov (United States)

    Ćwiek, Mateusz; Matusiak-Małek, Magdalena; Puziewicz, Jacek; Ntaflos, Theodoros

    2015-04-01

    The Pilchowice basanite (SW Poland) forms volcanic plug located exactly on Intrasudetic Fault, which is one of the major tectonic lines in northern part of the Bohemian Massif. It originated during the formation of Variscan Orogen and marks the contact between two different crustal domains. The basanite is rhönite-bearing (Ladenberger et al., 2005. Min.Pol-Spec. Pap.) and contains small (JoP), which is in an opposition to modal content of clinopyroxene (0-4.1 vol.%). This suggests, that clinopyroxene is a "stealth" metasomatic phase (O'Reillly and Griffin, 2013, Springer). As trace element composition of clinopyroxene shows features typical for reaction with alkaline silicate melt (negative inflection at the most incompatible trace elements) and carbonatite (Ti, Zr, Hf anomalies), we suggest that majority of xenoliths were metasomatized by the an agent being a carbonatite-silicate melt or by CO2-bearing alkaline silicate melt. Xenolith where clinopyroxene shows constant enrichment in LREE may represent a part of mantle affected by pure carbonatitic metasomatism. Xenoliths with the lowest Fo content in olivine are probably cumulates of mafic silicate melt. Intergranular aggregates originated during reaction between primary phases and infiltrating, possibly mafic melt. The "glassy patch" might be a product of complete breakdown of amphibole in upper mantle conditions (Shaw, 2009, Lithos). However, presence of rhönite in host basanite suggests that some amphibole might have been broken also in lower pressures. Chemical composition of peridotites from Pilchowice resembles that recorded by group A mantle xenoliths from Krzeniów (Matusiak-Małek et al., 2014, JoP). In Pilchowice we have described the first xenolith affected by purely carbonatitic metasomatism. We also suggest that hydrous phases might have been present in upper mantle beneath this Pilchowice, which is believed to be nominally anhydrous (Puziewicz et al., 2015, IJES, DOI 10.1007/s00531

  5. SW-MW infrared spectrometer for lunar mission

    Science.gov (United States)

    Banerjee, Arup; Biswas, Amiya; Joshi, Shaunak; Kumar, Ankush; Rehman, Sami; Sharma, Satish; Somani, Sandip; Bhati, Sunil; Karelia, Jitendra; Saxena, Anish; Chowdhury, Arup R.

    2016-04-01

    SW-MW Imaging Infrared Spectrometer, the Hyperspectral optical imaging instrument is envisaged to map geomorphology and mineralogy of lunar surface. The instrument is designed to image the electro-magnetic energy emanating from moon's surface with high spectral and spatial resolution for the mission duration from an altitude of 100 km. It is designed to cover 0.8 to 5 μm in 250 spectral bands with GSD 80m and swath 20km. Primarily, there are three basic optical segments in the spectrometer. They are fore optics, dispersing element and focusing elements. The payload is designed around a custom developed multi-blaze convex grating optimized for system throughput. The considerations for optimization are lunar radiation, instrument background, optical throughput, and detector sensitivity. HgCdTe (cooled using a rotary stirling cooler) based detector array (500x256 elements, 30μm) is being custom developed for the spectrometer. Stray light background flux is minimized using a multi-band filter cooled to cryogenic temperature. Mechanical system realization is being performed considering requirements such as structural, opto-mechanical, thermal, and alignment. The entire EOM is planned to be maintained at 240K to reduce and control instrument background. Al based mirror, grating, and EOM housing is being developed to maintain structural requirements along with opto- mechanical and thermal. Multi-tier radiative isolation and multi-stage radiative cooling approach is selected for maintaining the EOM temperature. EOM along with precision electronics packages are planned to be placed on the outer and inner side of Anti-sun side (ASS) deck. Power and Cooler drive electronics packages are planned to be placed on bottom side of ASS panel. Cooler drive electronics is being custom developed to maintain the detector temperature within 100mK during the imaging phase. Low noise detector electronics development is critical for maintaining the NETD requirements at different target

  6. [Effect of HIF-1α Gene Silence on Biological Characteristics of Human Colon Cancer Cells SW480].

    Science.gov (United States)

    Wang, Qiang; Hao, Lang-song; Shi, Jia; Huang, Jian

    2015-07-01

    To investigate changes in proliferation and apoptosis of human colon cancer SW480 cells after silencing hypoxia inducible factor-lα (HIF-1α) expression. siRNA interference technology was performed to silence the expression of HIF-1α using lipofectamine mediation to transfect siRNA into human colon cancer SW480 cells. The siRNA interfered SW480 cells were compared with a negative control group, an empty vector group, and a blank control group. Real-time PCR and Western blot were used to measure the expressions of HIF-lα protein and mRNA. MTT and flow cytometry (FCM) were used to evaluate the apoptosis and proliferation of SW480 cells. The interfered SW480 cells had a higher level of silence of HIF-lα mRNA (> 80%) compared with those of in the three control groups (P silencing promotes apoptosis and inhibits the proliferation of SW480 cells in vitro.

  7. Antitumor bioactivity of adenovirus-mediated p27mt in colorectal cancer cell line SW480

    Institute of Scientific and Technical Information of China (English)

    Ze-Qun sun; Chang-Sheng Deng; Shao-Yong Xu; Yong Du

    2008-01-01

    AIM: To explore the antitumor bioactivity of adenovirus-mediated mutant type p27kip1 gene in a colorectal cancer cell line SW480.METHODS: We constructed recombinant adenovirus vector expressing a mutant type p27kip1 gene (ad-p27mt), with mutation of Thr-187/Pro-188 (ACGCCC) to Met-187/Ile-188 (ATGATC), and transduced into SW480 cells. Then we detected expression of p27, Bcl-2 and Bax protein in the transductants by Western blotting, cell cycle of transductants by a digital flow cytometric system, migrating potential with Boyden Chamber end SW480 tumor cell growth inhibition in vitro and in vivo.RESULTS: We found that a recombinant adenovirus vector of expressing ad-p27mt, with mutation of Thr-187/Pro-188 (ACGCCC) to Met-187/Ile-188 (ATGATC) has potent inhibition of SW480 tumor cell growth in vitro and in vivo. Furthermore, ed-p27mt induced cell apoptosis via regulating bax and bcl-2 expressions, and G1/S arrest in SW480 cells and inhibited celt migration.CONCLUSION: ad-p27mt has a strong anti-tumor bioactivity and has the potential to develop into new therapeutic agents for colorectal cancer.

  8. On The Accretion Rates of SW Sextantis Nova-Like Variables

    CERN Document Server

    Ballouz, Ronald-Louis

    2009-01-01

    We present accretion rates for selected samples of nova-like variables having IUE archival spectra and distances uniformly determined using an infrared method by Knigge (2006). A comparison with accretion rates derived independently with a multi-parametric optimization modeling approach by Puebla et al.(2007) is carried out. The accretion rates of SW Sextantis nova-like systems are compared with the accretion rates of non-SW Sextantis systems in the Puebla et al. sample and in our sample, which was selected in the orbital period range of three to four and a half hours, with all systems having distances using the method of Knigge (2006). Based upon the two independent modeling approaches, we find no significant difference between the accretion rates of SW Sextantis systems and non-SW Sextantis nova-like systems insofar as optically thick disk models are appropriate. We find little evidence to suggest that the SW Sex stars have higher accretion rates than other nova-like CVs above the period gap within the same...

  9. District Energy Corporation SW 40th Street Thermal Energy Plant

    Energy Technology Data Exchange (ETDEWEB)

    Davlin, Thomas [District Energy Corporation, Lincoln, NE (United States)

    2014-06-06

    The overall deliverable from the project is the design, construction and commissioning of a detention facility heating and cooling system that minimizes ownership costs and maximizes efficiency (and therefore minimizes environmental impact). The primary deliverables were the proof of concept for the application of geothermal systems for an institutional facility and the ongoing, quarterly system operating data downloads to the Department of Energy . The primary advantage of geothermal based heat pump systems is the higher efficiency of the system compared to a conventional chiller, boiler, cooling tower based system. The higher efficiency results in a smaller environmental foot print and lower energy costs for the detention facility owner, Lancaster County. The higher efficiency for building cooling is primarily due to a more constant compressor condensing temperature with the geothermal well field acting as a thermal “sink” (in place of the conventional system’s cooling tower). In the heating mode, Ground Couple Heat Pump (GCHP) systems benefits from the advantage of a heat pump Coefficient of Performance (COP) of approximately 3.6, significantly better than a conventional gas boiler. The geothermal well field acting as a thermal “source” allows the heat pumps to operate efficiently in the heating mode regardless of ambient temperatures. The well field is partially located in a wetland with a high water table so, over time, the project will be able to identify the thermal loading characteristics of a well field located in a high water table location. The project demonstrated how a large geothermal well field can be installed in a wetland area in an economical and environmentally sound manner. Finally, the SW 40th Street Thermal Energy Plant project demonstrates the benefits of providing domestic hot water energy, as well as space heating, to help balance well filed thermal loading in a cooling dominated application. During the period of August 2012 thru

  10. Increased resistance to 14α-demethylase inhibitors (DMIs) in Aspergillus niger by coexpression of the Penicillium italicum eburicol 14α-demethylase (cyp51) and the A. Niger cytochrome P450 reductase (cprA) genes

    NARCIS (Netherlands)

    Brink, H.J.M. van den; Nistelrooy, H.J.G.M. van; Waard, M.A. de; Hondel, C.A.M.J.J. van den; Gorcom, R.F.M. van

    1996-01-01

    In this paper we describe the effects of over-expression of the Penicillium italicum gene encoding eburicol 14α-demethylase (cyp51), in Aspergillus niger strains with one or multiple copies of the gene encoding cytochrome P450 reductase (cpr A), on the eburicol 14α-demethylase activity. Eburicol 14α

  11. Running SW4 On New Commodity Technology Systems (CTS-1) Platform

    Energy Technology Data Exchange (ETDEWEB)

    Rodgers, Arthur J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Petersson, N. Anders [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Pitarka, Arben [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Sjogreen, Bjorn [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-08-30

    We have recently been running earthquake ground motion simulations with SW4 on the new capacity computing systems, called the Commodity Technology Systems - 1 (CTS-1) at Lawrence Livermore National Laboratory (LLNL). SW4 is a fourth order time domain finite difference code developed by LLNL and distributed by the Computational Infrastructure for Geodynamics (CIG). SW4 simulates seismic wave propagation in complex three-dimensional Earth models including anelasticity and surface topography. We are modeling near-fault earthquake strong ground motions for the purposes of evaluating the response of engineered structures, such as nuclear power plants and other critical infrastructure. Engineering analysis of structures requires the inclusion of high frequencies which can cause damage, but are often difficult to include in simulations because of the need for large memory to model fine grid spacing on large domains.

  12. NEW DATA ON MIDDLE DEVONIAN CONODONTS FROM SW-SARDINIA:THE SU NUARGI II SECTION REVISITED

    Directory of Open Access Journals (Sweden)

    SOFIE GOUWY

    2013-11-01

    Full Text Available The conodont collection from the nodular limestone beds of the Su Nuargi II outcrop near Domusnovas in SW-Sardinia (Italy is restudied for the purpose of reassessing the outcrop and updating the conodont collection to the most recent taxonomy. Su Nuargi II is the most important outcrop in the SW of the island exposing Middle Devonian rocks. Forty-five conodont taxa have been identified in the collection, positioning the outcrop within the interval covering the timorensis to latifossatus zones (Lower to Middle Givetian slightly widening the interpretation of Olivieri (1985. A new morphotype of Polygnathus linguiformis linguiformis is described. The genera Tortodus and Schmidtognathus are identified for the first time in the Middle Devonian of Sardinia. Additionally, a second Middle Devonian outcrop is discovered in the SW of the Island. 

  13. HW粗煤泥流化床分选试验研究与工艺优化%Experimental study and process optimization on separation of coarse slime using HW fluidized bed

    Institute of Scientific and Technical Information of China (English)

    张祖军

    2014-01-01

    This paper introduces principle and characters of HW fluidized bed sorting ma-chine for coarse slime��The HW fluidized bed separation experimental study of coarse slime with the diameter 2~0��074 mm in Baizhuagn Coal preparation plant has been conducted��The effects between velocity of water and slime with different diameter on the separation have been re-searched��The results showed that the technological process in Baizhuagn Coal preparation plant was optimized and HW sorting machine has been used for recover coarse slime with the diameter from 0��2~2 mm��The probable deviation of separation can be 0��08~0��1 1��After the technologi-cal process has been optimized,under the same ash of clean coal condition,clean coal yield could increase 4��09%.%介绍了HW粗煤泥流化床分选机的分选原理及特点,并对白庄煤矿选煤厂2~0��074 mm的粗煤泥进行HW流化床分选相关试验,探究了上升水流速对不同粒级煤泥的分选效果的影响.试验结果表明,针对白庄煤矿选煤厂的生产情况进行工艺优化,最终决定采用 HW粗煤泥分选机回收2~0��2 mm粒级粗煤泥,分选可能偏差达到0��08~0��11.经过改造后,选煤厂在保持精煤灰分不变的情况下,综合精煤产率提高了4��09%.

  14. Analysis of 58Co Activity Concentration in the Primary Coolant During CPR1000 NPP Shut Down for Outage%CPR1000停堆开盖一回路冷却剂中58Co放射性浓度分析

    Institute of Scientific and Technical Information of China (English)

    熊军; 蒋振宇; 唐邵华

    2013-01-01

    沉积于一回路系统设备内壁的活化腐蚀产物是压水堆核电厂停堆工况下的主要放射性来源.文中选择CPR1000停堆换料期间放射性浓度较高的活化腐蚀产物58Co作为研究对象,分析该核素在停堆开盖过程中放射性浓度变化的影响因素,并建立相应的放射性浓度计算模型.计算结果表明,一回路净化流量和附着于设备内壁的58Co释放率是影响停堆期间一回路冷却剂58Co放射性浓度变化的主要因素,同时从理论上得出了CPR1000机组停堆净化工序能够使得一回路冷却剂内58Co放射性浓度降至相关停堆放化控制限值内的结论.%Activated corrosion products which deposit on inner walls of primary coolant are the main radioactive sources in PWR NPPs during outage. A method for estimating the 58Co activity concentration during outage was proposed in this paper, By analysis, we can get that the purification rate and the release rate in the primary coolant are the main factors to changes of the 58Co activity concentration, and the 58Co activity concentration meet the related requirement of Outage limits in CPR1000 nuclear power plant.

  15. The Introduction of a Domestic Airborne LiDAR System SW-LiDAR%国产SW-LiDAR系统的简介

    Institute of Scientific and Technical Information of China (English)

    李志杰; 施昆; 关艳玲; 蒋凤保

    2013-01-01

    This paper introduced the structure, characteristics of a domestic airborne LiDAR systems SW-LiDAR and USES. This paper also provided highlights of inertial navigation principle, the principle of differential GPS and conformation equation, which is integrate theory. The workflow was introduced. Finally, the development trend of the system were prospected.%本文介绍国产机载SW-LiDAR系统的构成、特点和用途。重点阐述了该系统的三个集成原理:惯性导航原理、差分GPS原理和构象方程。介绍了该系统的工作流程。最后展望了该系统的应用前景。

  16. SW-100 FPSM Typical Fault Analysis of Broadcast Transmitter%SW-100FPSM广播发射机的典型故障探析

    Institute of Scientific and Technical Information of China (English)

    刘亮

    2014-01-01

    本文简要介绍了 PSM 短波广播发射机调制方式及工作原理,分析了 PSM 短波广播发射机优点。针SW-100FPSM广播发射机运行维护中出现的典型故障进行了分析研讨,提出了解决对策。%This paper briefly introduces the PSM shortwave broadcast transmitter modulation mode and working principle, analyses the PSM shortwave radio transmitter. It analyzed and put forward countermeasure for the typical fault in the main-tenance counter the SW-100FPSM shortwave broadcast transmitter.

  17. Maximizing Throughput of SW ARQ with Network Coding through Forward Error Correction

    Directory of Open Access Journals (Sweden)

    Farouq M. Aliyu

    2015-06-01

    Full Text Available Over the years, several techniques for improving throughput of wireless communication have been developed in order to cater for the ever increasing demand of high speed network service. However, these techniques can only give little improvement in performance because packets have to be delivered as is. As such researchers have begun thinking outside the box by proposing ideas that require relay nodes to temper packets’ contents in order to improve the throughput of a network. One of the state of the art techniques in this field is called Network Coding (NC. NC is a state of the art technique that allows relay nodes linearly combine two or more packets in a way they can be recovered upon reaching their destination. However, increasing packet size increases possibility of error affecting it. In this paper, the authors decide to investigate whether adding data recovery technique can improve the performance of a network that uses network coding, if it can, by how much can it? Is it worth the trouble? In order to answer these questions, the authors carried out a quantitative analysis of throughput in a Stop-and-Wait Automatic Repeat reQuest (SW-ARQ data transmission system with Network Coding (NC and Forward Error Correction (FEC. Vandermonde matrix is chosen as the coding technique for this research because it has both NC and data recovery characteristics. Python programming language is used to develop three Discrete Event Simulations: SW-ARQ without any NC, SW-ARQ with NC and SW-ARQ with NC and FEC. The obtained results show that SW-ARQ with NC and FEC is superior to traditional SW-ARQ in terms of throughput, especially in channels with high error rates.

  18. Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134.

    Science.gov (United States)

    Hashim, Yassar M; Spitzer, Dirk; Vangveravong, Suwanna; Hornick, Mary C; Garg, Gunjal; Hornick, John R; Goedegebuure, Peter; Mach, Robert H; Hawkins, William G

    2014-07-01

    Pancreatic adenocarcinoma is highly resistant to conventional therapeutics and has been shown to evade apoptosis by deregulation of the X-linked and cellular inhibitors of apoptosis proteins (XIAP and cIAP). Second mitochondria-derived activator of caspases (Smac) induces and amplifies cell death by reversing the anti-apoptotic activity of IAPs. Thus, Smac-derived peptide analogues (peptidomimetics) have been developed and shown to represent promising cancer therapeutics. Sigma-2 receptors are overexpressed in many proliferating tumor cells including pancreatic cancer. Selected ligands to this receptor are rapidly internalized by cancer cells. These characteristics have made the sigma-2 receptor an attractive target for drug delivery because selective delivery to cancer cells has the potential to increase therapeutic efficacy while minimizing toxicity to normal tissues. Here, we describe the initial characterization of SW IV-134, a chemically linked drug conjugate between the sigma-2 ligand SW43 and the Smac mimetic SW IV-52 as a novel treatment option for pancreatic adenocarcinoma. The tumor killing characteristics of our dual-domain therapeutic SW IV-134 was far greater than either component in isolation or in an equimolar mix and suggests enhanced cellular delivery when chemically linked to the sigma-2 ligand. One of the key findings was that SW IV-134 retained target selectivity of the Smac cargo with the involvement of the NF-κB/TNFα signaling pathway. Importantly, SW IV-134 slowed tumor growth and improved survival in murine models of pancreatic cancer. Our data support further study of this novel therapeutic and this drug delivery strategy because it may eventually benefit patients with pancreatic cancer.

  19. Analysis of Secondary Emergency Passive Heat Sink's Ability to Relieve Accident of CPR1000 With Different Main-Feedwater Line Break Area%主给水管道破口尺寸对CPR1000二次侧非能动应急热阱事故缓解能力影响研究

    Institute of Scientific and Technical Information of China (English)

    王明军; 张亚培; 田文喜; 苏光辉; 秋穗正

    2012-01-01

    The transient thermal hydraulic characteristics of CPR1000 were analyzed using RELAP5/MOD3. 4 code to verify the ability of the adopting water-cooled heat exchanger's emergency passive heat sink system (WEPHS) for accident mitigation under the condition of feed water line break (FLB) with different break area. The calculation results show that the WEPHS of CPR1000 can supply the water to steam generator immediately and remove the core residual heat after the FLB successfully. With the broken area increasing, the pressure and temperature of the primary loop increase higher, and decrease more sharply with the WEPHS operation. It also shows that the design of WEPHS of CPR1000 is effective.%在主给水管道破裂事故下,针对不同破口面积,利用RELAP5/MOD3.4程序对CPRI000压水堆一回路和二次侧非能动应急热阱的主要热工水力参数瞬态特性进行分析计算,验证采用CPRI000二次侧非能动应急热阱对事故的缓解能力和不同破口面积对主要参数的影响.结果表明:CPRI000在发生主给水管道破裂事故后,二次侧非能动应急热阱可及时向蒸汽发生器补水,同时导出堆芯余热,保证反应堆处于安全状态,随着破口面积的增大,初始时刻一回路压力和温度升高更快,随着二次侧非能动应急热阱的投入,压力和温度又迅速降低,说明CPR1000二次侧非能动应急热阱在文中所研究的破口面积范围内可非常有效地缓解事故.

  20. [End-of-life care in emergency settings in the super-aged society: withholding CPR from frail elderly with severe ADL impairment].

    Science.gov (United States)

    Aita, Kaoruko

    2013-06-01

    Emergency and intensive care unit demographics have changed with the advent of the super-aged society in Japan. Japan has the highest population aging rate in the world. It is now predicted that an increasing number of people will die at higher age. The oldest old individuals show increasing frailty, with an excess vulnerability to stressors. It is believed that frail elderly would receive limited benefit from highly invasive emergency treatment and advanced intensive care which, on the contrary, could bring about harmful effects on frail elderly. So far a number of frail oldest-old nursing home residents with cardiopulmonary arrest have been taken by ambulance to emergency medical centers to receive cardio-pulmonary resuscitation in vain in Japan. Now is the time to stop the harmful ritual. Withholding CPR from frail elderly with severe ADL impairment would not constitute an act of ageism but the act of humanity based on medical evidence.

  1. Geochemical significance of the relative enrichment of pristane and the negative excursion of δ13CPr across the Permian-Triassic Boundary at Meishan, China

    Institute of Scientific and Technical Information of China (English)

    WANG Chunjiang; LIU Yimei; LIU Hongxiu; ZHU Lei; SHI Quan

    2005-01-01

    Changes in the distribution of isoprenoid hydrocarbons and in δ13Ckero or δ13CPr across the section from the Changxing Formation to the lower Yinkeng Formation at Meishan (the GSSP of PTB) are studied, in which a relative enrichment of pristane and a sharp shift in both δ13Ckero and δ13Cmole near the boundary are revealed. A possible mechanism for the abnormal accumulation of pristane near PTB is suggested: Lipids in some marine animals and their metabolites, rich in pristane, can be preserved and accumulate in some suitable depositing facies under certain special conditions, such as the catastrophic death of animals and/or developing of an anoxic water column, and thus the pristane enrichment occurs in the sediment. The occurrences of isoprenoid enrichment and high Pr/Ph ratios have been found in other typical marine anoxic sediments accompanied by mass extinction in various extent during the most important geological periods, such as Late Ordovician, end of Devonian, Early Jurassic and Late Cretaceous. These occurrences support to a certain extent the above mechanism that interprets the genesis of a high Pr/Ph ratio in some typical marine anoxic sediments. The synchronous sharp negative shifts in δ13Cmole, δ13Ckero and δ13Ccarb from Beds 24 to 26 of the Meishan profile indicate that a sudden and strong variation of carbon source in the atmosphere-ocean system occurred during the quick but equable evolution from the end-Permian to Early Triassic, and the coupling between the pristane enrichment and negative shift in δ13Ckero and δ13CPr may well indicate the importance of the release of methane hydrates and marine anoxia in the end-Permian mass extinction.

  2. The design of instructional tools affects secondary school students' learning of cardiopulmonary resuscitation (CPR) in reciprocal peer learning: a randomized controlled trial.

    Science.gov (United States)

    Iserbyt, Peter; Byra, Mark

    2013-11-01

    Research investigating design effects of instructional tools for learning Basic Life Support (BLS) is almost non-existent. To demonstrate the design of instructional tools matter. The effect of spatial contiguity, a design principle stating that people learn more deeply when words and corresponding pictures are placed close (i.e., integrated) rather than far from each other on a page was investigated on task cards for learning Cardiopulmonary Resuscitation (CPR) during reciprocal peer learning. A randomized controlled trial. A total of 111 students (mean age: 13 years) constituting six intact classes learned BLS through reciprocal learning with task cards. Task cards combine a picture of the skill with written instructions about how to perform it. In each class, students were randomly assigned to the experimental group or the control. In the control, written instructions were placed under the picture on the task cards. In the experimental group, written instructions were placed close to the corresponding part of the picture on the task cards reflecting application of the spatial contiguity principle. One-way analysis of variance found significantly better performances in the experimental group for ventilation volumes (P=.03, ηp2=.10) and flow rates (P=.02, ηp2=.10). For chest compression depth, compression frequency, compressions with correct hand placement, and duty cycles no significant differences were found. This study shows that the design of instructional tools (i.e., task cards) affects student learning. Research-based design of learning tools can enhance BLS and CPR education. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  3. Study of the gamma irradiation effects on the PMMA/HA and PMMA/SW

    Science.gov (United States)

    Silva, P.; Albano, C.; Perera, R.; Domínguez, N.

    2010-03-01

    The behavior of the poly(methyl methacrylate) (PMMA) under the action of gamma radiation has been sufficiently studied. In this work, we present results from melt flow index (MFI), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and electron paramagnetic resonance (EPR) of PMMA composites with hydroxyapatite (HA) and seaweed residues (SW) irradiated with gamma rays at 1.08 kGy/h. Composites of PMMA/HA and PMMA/SW with 10%, 20% and 30% of the filler were prepared. The results show an increase in the MFI values with the integral dose of radiation, being consistent with chain-scission reactions. No EPR signal was observed in pure PMMA, while in the composites, the typical EPR signal of the PMMA radicals was observed, which increased with the amount of HA or SW. When comparing the relative intensities of the EPR signals for both types of composites, a slight increase in the concentration of free radicals generated in the sample with SW respect to that of PMMA/HA composite was obtained. A decay of the total free radical concentration was observed as time elapsed.

  4. Ecosystem metabolism in a temporary Mediterranean marsh (Donana National Park, SW Spain)

    DEFF Research Database (Denmark)

    Geertz-Hansen, O.; Montes, C.; Duarte, C.M.

    2011-01-01

    metabolic balance of the open waters supporting submerged macrophytes of the Donana marsh (SW Spain) was investigated in spring, when community production is highest. The marsh community (benthic + pelagic) was net autotrophic with net community production rates averaging 0.61 g C m(-2) d(-1), an...

  5. Metamorphism of siliceous dolomites in the high-grade Precambrian of Rogaland, SW Norway

    NARCIS (Netherlands)

    Sauter, P.C.C.

    1983-01-01

    In the Precambrian granulite facies terrain of Rogaland, SW Norway, some small occurrences of marbles are present. They are mainly exposed at three locations A, Band C, at increasing distance from the anorthositic and monzonitic intrusions. The Precambrian basement in Rogaland has undergone several

  6. Geochemistry of high-temperature granulitic supracrustals from Rogaland, SW Norway

    NARCIS (Netherlands)

    Bol, L.C.G.M.

    1990-01-01

    Were the granulite-facies metamorphic supracrustals of the Faurefjell Metasediment Formation in Rogaland, SW Norway, chemically open or closed systems? In order to assess differential element mobilities in response to pre-, syn- and post-metamorphic fluid fluxes through this formation, the mineralog

  7. Lower Maastrichtian cyclostratigraphy of the Bidart section (Basque Country, SW France)

    DEFF Research Database (Denmark)

    Husson, Dorothée; Thibault, Nicolas Rudolph; Galbrun, Bruno

    2014-01-01

    Cyclostratigraphic analysis of the Maastrichtian limestone-marl alternations of Bidart (SW France) allows the hypothesis of orbital control on lithological cycles to be evaluated. Magnetic Susceptibility (MS), oxygen and carbon isotope measurements, sampled at a high resolution, are analyzed using...

  8. sw-SVM: sensor weighting support vector machines for EEG-based brain-computer interfaces.

    Science.gov (United States)

    Jrad, N; Congedo, M; Phlypo, R; Rousseau, S; Flamary, R; Yger, F; Rakotomamonjy, A

    2011-10-01

    In many machine learning applications, like brain-computer interfaces (BCI), high-dimensional sensor array data are available. Sensor measurements are often highly correlated and signal-to-noise ratio is not homogeneously spread across sensors. Thus, collected data are highly variable and discrimination tasks are challenging. In this work, we focus on sensor weighting as an efficient tool to improve the classification procedure. We present an approach integrating sensor weighting in the classification framework. Sensor weights are considered as hyper-parameters to be learned by a support vector machine (SVM). The resulting sensor weighting SVM (sw-SVM) is designed to satisfy a margin criterion, that is, the generalization error. Experimental studies on two data sets are presented, a P300 data set and an error-related potential (ErrP) data set. For the P300 data set (BCI competition III), for which a large number of trials is available, the sw-SVM proves to perform equivalently with respect to the ensemble SVM strategy that won the competition. For the ErrP data set, for which a small number of trials are available, the sw-SVM shows superior performances as compared to three state-of-the art approaches. Results suggest that the sw-SVM promises to be useful in event-related potentials classification, even with a small number of training trials.

  9. Lateglacial and early Holocene tephrostratigraphy and sedimentology of the Store Slotseng basin, SW Denmark

    DEFF Research Database (Denmark)

    Larsen, Jeppe Joel; Noe-Nygaard, Nanna

    2014-01-01

    The history of the Lateglacial and Preboreal sedimentary succession from the Store Slotseng kettle hole basin, SW Denmark is presented. A tephrostratigraphical and multi-proxy investigation of the sediments, including stable isotope geochemistry, reveals small- and large-scale changes...

  10. Properties of cast films made of chayote (Sechium edule Sw.) tuber starch reinforced with cellulose nanocrystals

    Science.gov (United States)

    In this study, cellulose (C) and cellulose nanocrystals (CN) were blended with chayote tuber (Sechium edule Sw.) starch (CS) in formulations cast into films. The films were conditioned at different storage temperatures and relative humidity (RH), and analyzed by mechanical tests, X-ray diffraction, ...

  11. The relationship between orogenesis and sedimentation in the SW part of the Cantabrian Mountains (NW Spain)

    NARCIS (Netherlands)

    Bosch, van den W.J.

    1969-01-01

    The structures in the SW part of the Cantabrian Mountains have much in common with those of the Foothills Belt of the Rocky Mountains, the Alps and the Central European Hercynian orogene, and their origin can be explained in the same way as that of the structures in these orogenes. The greywacke sed

  12. Palynological evidence for late-Holocene human occupation recorded in two wetlands in SW Turkey

    NARCIS (Netherlands)

    Vermoere, M; Bottema, S; Vanhecke, L; Waelkens, M; Paulissen, E; Smets, E

    2002-01-01

    Pollen diagrams from mountain lakes and marshes in SW Turkey show evidence of intensive anthropogenic influence in the landscape between 3500 and 1300 BP. Three cores from within the territory of the classical city Sagalassos (Western Taurus, Pisidia) were palynologically analysed to make a reconstr

  13. Strangelet search in S-W collisions at 200A GeV/c

    Science.gov (United States)

    Borer, K.; Dittus, F.; Frei, D.; Hugentobler, E.; Klingenberg, R.; Moser, U.; Pretzl, K.; Schacher, J.; Stoffel, F.; Volken, W.; Elsener, K.; Lohmann, K. D.; Baglin, C.; Bussière, A.; Guillaud, J. P.; Appelquist, G.; Bohm, C.; Hovander, B.; Selldèn, B.; Zhang, Q. P.

    1994-03-01

    A search for new massive particles with a low charge to mass ratio in S-W collisions at a beam momentum of 200 GeV/c per nucleon is presented. Upper limits for the production of strangelets with a mass to charge ratio of up to 60 GeV/c2 at rigidities of +/-150 GV are reported.

  14. Supporting document for the SW Quadrant Historical Tank Content Estimate for U-Tank Farm

    Energy Technology Data Exchange (ETDEWEB)

    Brevick, C.H.; Gaddis, L.A.; Johnson, E.D.

    1994-06-01

    This Supporting Document provides historical characterization information gathered on U-Tank Farm, such as historical waste transfer and level data, tank physical information, temperature data, sampling data, and drywell and liquid observation well data for Historical Tank Content Estimate of the SW Quadrant at the Hanford 200 West Area.

  15. Study of the gamma irradiation effects on the PMMA/HA and PMMA/SW

    Energy Technology Data Exchange (ETDEWEB)

    Silva, P., E-mail: silva@ivic.v [Instituto Venezolano de Investigaciones Cientificas, Centro de Fisica, Carretera Panamericana Km. 11, Caracas 1020-A (Venezuela, Bolivarian Republic of); Albano, C. [Universidad Central de Venezuela, Facultad de Ingenieria (Venezuela, Bolivarian Republic of); Instituto Venezolano de Investigaciones Cientificas, Centro de Quimica (Venezuela, Bolivarian Republic of); Perera, R. [Departamento de Mecanica, Universidad Simon Bolivar, Caracas 1080-A (Venezuela, Bolivarian Republic of); Dominguez, N. [Instituto Venezolano de Investigaciones Cientificas, Centro de Quimica (Venezuela, Bolivarian Republic of)

    2010-03-15

    The behavior of the poly(methyl methacrylate) (PMMA) under the action of gamma radiation has been sufficiently studied. In this work, we present results from melt flow index (MFI), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and electron paramagnetic resonance (EPR) of PMMA composites with hydroxyapatite (HA) and seaweed residues (SW) irradiated with gamma rays at 1.08 kGy/h. Composites of PMMA/HA and PMMA/SW with 10%, 20% and 30% of the filler were prepared. The results show an increase in the MFI values with the integral dose of radiation, being consistent with chain-scission reactions. No EPR signal was observed in pure PMMA, while in the composites, the typical EPR signal of the PMMA radicals was observed, which increased with the amount of HA or SW. When comparing the relative intensities of the EPR signals for both types of composites, a slight increase in the concentration of free radicals generated in the sample with SW respect to that of PMMA/HA composite was obtained. A decay of the total free radical concentration was observed as time elapsed.

  16. 概率安全评价在CPR1000机组严重事故预防与缓解措施分析中的应用%Application of Probabilistic Safety Assessment in CPR1000 Severe Accident Prevention and Mitigation Analysis

    Institute of Scientific and Technical Information of China (English)

    刘萍萍; 张宁

    2011-01-01

    The relationship between probabilistic safety assessment (PSA) and severe accident study was discussed. Also how to apply PSA in severe accident prevention and mitigation was elaborated. PSA can find the plant vulnerabilities of severe accidents prevention and mitigation. Some modifications or improvements focusing on these vulnerabilities can be put forward. PSA also can assess the efficient of these actions for decision-making. According to CPR1000 unit severe accident analysis, an example for the process and method on how to use PSA to enhance the ability to deal with severe accident prevention and mitigation was set forth.%文章阐述了概率安全评价(PSA)与严重事故分析之间的关系,介绍了PSA在严重事故预防与缓解措施分析中的应用过程与方法,通过PSA分析,发现了核电厂严重事故预防与缓解的薄弱环节,提出相应的改进措施,并从核安全风险角度对这些措施的有效性进行评价.文章结合CPR1000机组严重事故预防与缓解措施的研究,说明了PSA在严重事故研究中的应用.

  17. [Label-free monitoring 5-FU induced SW 620 cells apoptosis using FTIR microspectroscopy].

    Science.gov (United States)

    Liu, Dong; Sun, Xue-Jun; Zhang, Chao; He, Sai; Du, Jun-Kai; Huo, Xiong-Wei; Zheng, Jian-Bao; Zhang, Shi-Yun; Zhang, Yuan-Fuz; Xu, Yi-Zhuang; Wu, Jin-Guang

    2013-12-01

    The aim of the present study was to evaluate Fourier transform infrared spectroscopy (FTIR) monitoring of biochemical changes in apoptosis cells. Different concentrations of 5-fluorouracil (5-FU) treated colon cancer cell lines SW620 were used to determine the optimum concentration of 5-FU IC50 by means of MTT assay. Cell starvation and 5-Fu synergistic cell cycle arrest was in G1 and S phase. FTIR combined with flow cytometry was applied to analysis of SW 620 cells and SW620 cells treated with 5-FU for 12h, 24h (early apoptosis) and 48 h (late apoptosis) respectively. The peak position and the intensity of all bands were measured and comparison was made between the SW620 and apoptotic SW620 cells. Apoptosis cells have following characteristics compared with SW620 cells (1) The band at 1 740 cm-1 is an C=O stretching vibration. Changes in these bands can reflect lipid changes, and relative peak intensity ratio 11740/11460 significantly increased (p<0. 05), indicating that the relative contents of lipid in apoptosis cells increased. (2) The band at the 1 410 cm-1 peak represents that C-H stretching related was increased to amino acid residues and shifted to higher wave numbers compared to other groups. I1410o/I 460 at early and late death phase was significantly increased, which suggests that the relative contents of amino acid residues in apoptosis cells increased (p <0. 05). New vibrational bands at 1 120 cm-1 appeared at 24 h and increased at 48 h compared with other groups. The 1 120 cm-1 absorption band is mainly due to ser, serine and threonine C-O(H) stretching vibration, and I1120/I 1460 significantly increased (p<0. 05), indicating that the relative quantity of amino acid residues in apoptosis cells increased due to that DNA unwinds the double helix. (3) 1 240 cm-1 is mainly due to the asymmetric stretching modes of phosphodiester groups shifting to higher wave number, illustrating that nucleic acid conformation was changed in apoptosis cells. (4) The band

  18. INVESTIGATION OF COGNITION STATUS ABOUT BASIC CPR OF PRIMARY CAREGIVERS OF HEART DISEASE PATIENTS%心脏病患者主要照顾者基础心肺复苏的认知现状调查

    Institute of Scientific and Technical Information of China (English)

    缪爱凤; 钱海兰; 钱红继; 沈王琴

    2011-01-01

    [Objective] To understand the cognition status about basic CPR of primary caregivers of heart disease patients and its influencing factors, to provide evidences for training relatives of heart disease patients. [Methods] Used self-designed scale to investigate training status and cognition level of 92 primary caregivers, that patients were in hospital between March to July in 2011. [Results] 15.2% of the caregivers participated the CPR training, 37% heard the term of CPR, and 25% of caregivers had understood the basic knowledge of CPR. The evaluation score of CPR knowledge was 25.00 ± 20.083 points, 2.2% pass rate; there was no people answer correctly to the questions of the frequency and the depth of external cardiac massage , as well as the ratio of artificial respiration and external cardiac massage. The CPR knowledge scores were closely related with educational level and income (P < 0.05). [Conclusion] The CPR training rate of caregivers is low, and most of people lack of knowledge. Strengthening heart disease primary caregivers with the CPR training will be able to effectively reduce the mortality and morbidity due to cardiac arrest outside of the hospital.%[目的]了解心脏病患者主要照顾者对基础心肺复苏的认知现状及影响因素的调查,为心脏病患者家属进行CPR培训提供相关的依据. [方法]利用自行设计量表对2011年3~7月入住某院CCU病房患者的主要照顾者92人进行培训现状和知识水平的问卷调查. [结果]15.2%的人参加过CPR培训,37.0%听说过CPR 一词,25.0%了解CPR知识;CPR知识测评均分为(25.00±20.083)分,及格率2.2%,对胸外心脏按压的频率、深度、人工呼吸与胸外心脏按压的比例无一人回答正确,CPR知识得分与学历、收入有关系(P<0.05). [结论]心脏病患者主要照顾者CPR培训率低,知识水平欠缺,加强心脏病患者主要照顾者CPR培训将能有效地降低院外心脏骤停的死亡率和致残率.

  19. Seismological structures of the subducted Philippine Sea plate and the overriding SW Japan arc, - Reinterpretation of the wide-angle reflection data in the Kii Peninsula, SW Japan -

    Science.gov (United States)

    Iwasaki, Takaya; Kurashimo, Eiji; Abe, Susumu; Yokota, Ken; Iidaka, Takashi; Katao, Hiroshi; Higashinaka, Motonori; Nakanishi, Ayako; Kaneda, Yoshiyuki

    2017-04-01

    Our recent reinterpretation for seismic refraction/wide-angle reflection data in eastern Kii Peninsula, SW Japan, provided new structural information on the uppermost part of the subducted Philippine Sea (PHS) plate and overriding the SW Japan arc, including the landward reflectivity variation in the vicinity of the plate boundary and the large scale structural change within the SW Japan arc. The Kii peninsula is located in the eastern part of the well-known subduction zone along the Nankai trough where offshore M8-class megathrust earthquakes repeatedly occur. The plate boundary beneath this Peninsula is in the stable or conditionally stable regime except for its southernmost tip, which corresponds to the northwestern end of the rupture area at the last event (1944 Tonankai earthquake (M7.9)). The surface geology of the overriding SW Japan arc is divided to two parts by the E-W trending Median Tectonic Line (MTL), the most prominent tectonic boundary in SW Japan. South of the MTL, Cretaceous-Jurassic accretionary complexes are exposed, whose northernmost unit consists of high P-T metamorphic rocks (the Sanbagawa metamorphic belt (SMB)). The region north of the MTL is occupied by older accretionary complexes, partly suffered from the Cretaceous magmatic intrusions. Our seismic data from five dynamite shots were acquired in 2006 along 80-km line almost perpendicular to the Nankai trough. The structure of the SW Japan arc was obtained both from intensive wide-angle reflection analysis and advanced reflection processing by seismic interferometry technique. The former analysis delineated clear structural change in the uppermost crust across the MTL. In the latter processing, we retrieved virtual shot records at 512 receiver points from free-surface backscattered waves by the deconvolution interferometry. The subsequent CRS (Common Reflection Surface)/MDRS (Multi-Dip Reflection Surfaces) methods provided an enhanced image within the island arc, including a northward

  20. The Influence of Mulberry Fruit Juice on Proliferation and Apoptosis of Colon Cancer Cell Line SW620%桑椹汁对结肠癌细胞株SW620增殖和凋亡的影响

    Institute of Scientific and Technical Information of China (English)

    吕欢; 闻燕; 王俊; 许晓风; 吴宇; 江明珠

    2013-01-01

    To confirm anti-tumor function of mulberry fruit, colon cancer cell line SW620 was treated with different concentrations of mulberry fruit juice. The growth curve was drawn by MTT method to investigate proliferation of SW620 cells. Change of transcriptional level of apoptosis-related gene p53 in SW620 cells and expression level of its encoded protein were detected by fluorescent quantitative PCR and SDS-PAGE to analyze the influencing mechanism of mulberry fruit juice on proliferation and apoptosis of colon cancer cell line SW620. It was found that the inhibitory effect of mulberry fruit juice on the proliferation of SW620 cells was enhanced obviously with the increase of mulberry fruit juice concentration. After being treated with mulberry fruit juice containing 6. 267 3 ×10-3 mg/mL anthocyanin for 24 h, SW620 cells had the following remarkable changes. Cell growth was obviously inhibited. Cells exfoliated and deformed. Cell adherence declined and cell apoptosis was observed. Genomic DNA of SW620 cells showed obvious degradation. The result of fluorescent quantitative PCR showed that expression level of gene p53 in the experimental group increased by 6. 5 folds compared with the control group. In addition, SDS-PAGE assay indicated that the expression level of protein p53 in the experimental group was also obviously higher than that in the control group. These results indicated that mulberry fruit juice has inhibitory effect on proliferation of colon cancer cell line SW620. The inhibitory mechanism may be related to cell apoptosis caused by up-regulation of p53 gene in SW620 cells which was induced by active ingredients of mulberry fruit juice.%为证实桑椹的抗肿瘤功能,以不同浓度桑椹汁处理结肠癌细胞株SW620,应用MTT法对比绘制生长曲线,调查SW620细胞的增殖情况,通过荧光定量PCR、SDS-PAGE检测SW620细胞凋亡相关基因p53的转录及蛋白质表达变化,分析桑椹汁对SW620细胞增殖、凋亡的影响机制.结果显示,桑椹汁对SW

  1. The Legionella pneumophila IcmSW complex interacts with multiple Dot/Icm effectors to facilitate type IV translocation.

    Directory of Open Access Journals (Sweden)

    Eric D Cambronne

    2007-12-01

    Full Text Available Many gram-negative pathogens use a type IV secretion system (T4SS to deliver effector proteins into eukaryotic host cells. The fidelity of protein translocation depends on the efficient recognition of effector proteins by the T4SS. Legionella pneumophila delivers a large number of effector proteins into eukaryotic cells using the Dot/Icm T4SS. How the Dot/Icm system is able to recognize and control the delivery of effectors is poorly understood. Recent studies suggest that the IcmS and IcmW proteins interact to form a stable complex that facilitates translocation of effector proteins by the Dot/Icm system by an unknown mechanism. Here we demonstrate that the IcmSW complex is necessary for the productive translocation of multiple Dot/Icm effector proteins. Effector proteins that were able to bind IcmSW in vitro required icmS and icmW for efficient translocation into eukaryotic cells during L. pneumophila infection. We identified regions in the effector protein SidG involved in icmSW-dependent translocation. Although the full-length SidG protein was translocated by an icmSW-dependent mechanism, deletion of amino terminal regions in the SidG protein resulted in icmSW-independent translocation, indicating that the IcmSW complex is not contributing directly to recognition of effector proteins by the Dot/Icm system. Biochemical and genetic studies showed that the IcmSW complex interacts with a central region of the SidG protein. The IcmSW interaction resulted in a conformational change in the SidG protein as determined by differences in protease sensitivity in vitro. These data suggest that IcmSW binding to effectors could enhance effector protein delivery by mediating a conformational change that facilitates T4SS recognition of a translocation domain located in the carboxyl region of the effector protein.

  2. Non-perturbative evaluation of cSW for smeared link clover fermion and Iwasaki gauge action

    CERN Document Server

    Taniguchi, Yusuke

    2013-01-01

    We performed a rough estimate of the non-perturbative value of the clover term coefficient cSW for the APE stout link Wilson fermion. We varied the number of smearings from Nsmear=1 to 6 and adopted beta values roughly corresponding to the lattice spacing of 0.1 fm. We used the Schroedinger functional technique for an evaluation of cSW and found that cSW decreases monotonically as we increase Nsmear but has a 10% order of deviation from the tree level value for Nsmear=6.

  3. 75 FR 10026 - Proposed Collection; Comment Request for Forms W-2, W-2c, W-2AS, W-2GU, W-2VI, W-3, W-3c, W-3cPR...

    Science.gov (United States)

    2010-03-04

    ... Internal Revenue Service Proposed Collection; Comment Request for Forms W-2, W-2c, W-2AS, W-2GU, W-2VI, W-3, W-3c, W-3cPR, W-3PR, and W-3SS AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and... comments concerning Forms W-2, W-2c, W-2AS, W-2GU, W-2VI, W-3,......

  4. Effect of the multimedia coordinations dummy on CPR- BLS skills in clinical nurses%多媒体配合模拟人对护理人员心肺复苏技能培训的效果

    Institute of Scientific and Technical Information of China (English)

    李蕾; 韩俏英; 汪广秀

    2009-01-01

    目的 研究多媒体配合模拟人对护理人员进行心肺复苏技能培训的效果.方法 采用多媒体配合模拟人对护理人员心肺复苏技能进行培训,比较培训前后护理人员考核成绩.结果 培训后护理人员对模拟人通气、按压正确率明显高于于培训前,培训后护理人员的操作成绩较培训前明显提高(P均<0.01).结论 采用多媒体配合模拟人对护理人员进行心肺复苏技能培训能明显提高护理人员的心肺复苏技能水平.%Objective To explore effect of the multimedia coordinations dummy on CPR - BLS skills in efinical nurses. Methods They were trained by the multimedia coordinations to simulate the human on CPR - BLS skills in elinieal nurses. To according to simulating the person voice prompt ventilation, holds back correctly or not and the performance of single before and after the training in performing the skills of CPR was evaluated and compared. Results The results after the training were significantly higher than those before the training (P <0.01) .Conclusions Multimedia coordinations dummy can improve the training of CPR skills in nurses.

  5. Strategies to improve performance od SW-SAGD (Single Well-Steam Assisted Gravity Drainage); Estrategias para melhor desempenho do SW-SAGD

    Energy Technology Data Exchange (ETDEWEB)

    Moreira, Richard Douglas Ribeiro [Norse Energy do Brasil S/A, Rio de Janeiro, RJ (Brazil); Trevisan, Osvair Vidal [Universidade Estadual de Campinas (UNICAMP), SP (Brazil)

    2008-07-01

    The present work presents an extensive numerical study, using a commercial reservoir simulator, on the recovery of heavy oil by steam injection assisted by gravity drainage in single horizontal wells. The goal is to study several strategies to improve performance of the Single Well - Steam Assisted Drainage Gravity (SW-SAGD), a new but promising thermal recovery technique aimed at exploitation of heavy oils. The strategies are basically made up of two measures: cyclic steam injection prior to the main injection-production process; and well bore splitting into injection and production zones by packer settings. The measures are scrutinized when used separately or together. Cyclic injection is varied according to cycle duration. Comparisons are made between the performance of oil recovery for the developed strategies and the performance of the traditional dual well SAGD technique with similar operating parameters and field conditions. The results point out the best strategy regarding key parameters such as the oil recovery factor and the steam oil ratio. Results were also verified for variations of rock and fluid properties in the range of a typical heavy oil reservoir. As a result, a new strategy for the SW-SAGD process is presented, providing oil recovery, which is higher than that yielded by the equivalent DW-SAGD. (author)

  6. ESTABILIDAD DE ANTOCIANINAS EN JUGO Y CONCENTRADO DE AGRAZ (VACCINIUM MERIDIONALE SW. STABILITY OF ANTHOCYANINS IN JUICE AND CONCENTRATE OF AGRAZ(VACCINIUM MERIDIONALE SW.

    Directory of Open Access Journals (Sweden)

    José Jobanny Martínez Zambrano

    2011-06-01

    Full Text Available Se estudió la cinética de la estabilidad térmica y de almacenamiento de las antocianinas en jugo y concentrado de agraz (Vaccinium meridionale Sw. siguiendo una cinética de primer orden. La degradación de las antocianinas con la temperatura fue modelada adecuadamente con la ecuación de Arrhenius. El efecto del pH en la estabilidad térmica de las antocianinas en los concentrados de agraz se estudió a seis diferentes valores (3,0 - 8,0 en buffer citrato-fosfato. La degradación de las antocianinas fue mayor para el jugo que para el concentrado. Una disminución significante en la estabilidad de las antocianinas del concentrado se observó a pH cercano a 5,0.The kinetics of thermal and storage stabilities of anthocyanins in agraz (Vaccinium meridionale Sw. juice and concentrate were studied with first-order reaction kinetics. The temperature-dependent degradation was adequately modeled on the Arrhenius equation. The effect of pH on thermal stability of anthocyanins in concentrate of agraz was studied at six different pHs (3.0 - 8.0 in citrate-phosphate buffer solutions. The results indicated that anthocyanins degradation was higher in juice than concentrate. A significant decrease in anthocyanin stability was observed at pHs above 5.0.

  7. 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis.

    Science.gov (United States)

    Patil, Jaiprakash R; Jayaprakasha, Guddadarangavvanahally K; Kim, Jinhee; Murthy, Kotamballi N Chidambara; Chetti, Mahadev B; Nam, Sang-Yong; Patil, Bhimanagouda S

    2013-03-01

    For the first time, three coumarins were isolated from the hexane extract of limes (Citrus aurantifolia) and purified by flash chromatography. The structures were identified by NMR (1D, 2D) and mass spectral analyses as 5-geranyloxy-7-methoxycoumarin, limettin, and isopimpinellin. These compounds inhibited human colon cancer (SW-480) cell proliferation, with 5-geranyloxy-7-methoxycoumarin showing the highest inhibition activity (67 %) at 25 µM. Suppression of SW480 cell proliferation by 5-geranyloxy-7-methoxycoumarin was associated with induction of apoptosis, as evidenced by annexin V staining and DNA fragmentation. In addition, 5-geranyloxy-7-methoxycoumarin arrested cells at the G0/G1 phase, and induction of apoptosis was demonstrated through the activation of tumour suppressor gene p53, caspase8/3, regulation of Bcl2, and inhibition of p38 MAPK phosphorylation. These findings suggest that 5-geranyloxy-7-methoxycoumarin has potential as a cancer preventive agent. Georg Thieme Verlag KG Stuttgart · New York.

  8. Synergistic antitumor effect of TRATL and doxorubicin on colon cancer cell line SW480

    Institute of Scientific and Technical Information of China (English)

    Li-Hong Xu; Chang-Sheng Deng; You-Qing Zhu; Shi-Quan Liu; Dong-Zhou Liu

    2003-01-01

    AIM: TRAIL (tumor necrosis factor-related apoptosisinducing ligand) has been reported to specifically induce apoptosis of cancer cells although only a small percentage of cell lines were sensitive to it. Cell lines not responding to TRAIL in vitro were said to be more prone to apoptosis when TRAIL was combined with another anticancer agent.Generally, factors affecting drug-sensitivity involve many apoptosis-related proteins, including p53. The expression of wild-type p53 gene was proposed as an important premise for tumor cells responding to chemotherapy. The present study was to investigate the cell killing action of TRAIL on colon cancer cell line SW480, its synergistic effect with doxorubicin, and the possible mechanisms. METHODS: SW480 cells were cultured in the regular condition and incubated with different levels of agents.Morphologic changes in these cells after treatment were observed under phase-contrast microscope and cytotoxicity by TRAIL alone and in combination with doxorubicin was quantified by a 1-day microculture tetrazolium dye (MTT)assay. In addition, flow cytometry assay (FCM) and transmission electron microscopy were used to detectapoptosis among these cells. Variation of p53 protein level among different groups according to concentrations of agents was measured by Western blot assay.RESULTS: (1) SW480 cells were not sensitive to TRAIL,with IC50>1 mg@L1 and dose-independent cytotoxicity. (2)SW480 cells were sensitive to doxorubicin at a certain degree,with dose-dependent cytotoxicity and IC50=65.25+3.48μmol@L-1. (3) TRAIL could synergize with doxorubicin to kill SW480 cells effectively, which was represented by the boosted killing effect of doxorubicin on theses cells. IC50 of doxorubicin against SW480 cells sharply reduced when it was combined with TRAIL. (4) Subtoxic TRAIL (100 μg.L-1),combined with subtoxic doxorubicin (0.86 μmol@L1), could kill SW480 cells sufficiently. Cytotoxicity by MTT assay arrived at 80.12+2.67%, which was

  9. On the SW Sex-Type Eclipsing Cataclysmic Variable SDSS0756+0858

    CERN Document Server

    Tovmassian, Gagik; Gonzalez-Buitrago, Diego; Zharikov, Sergey; García-Díaz, Maria Teresa

    2014-01-01

    We conducted a spectroscopic and photometric study of SDSS J075653.11+085831. X-ray observations were also attempted. We determined the orbital period of this binary system to be 3.29 hours. It is a deep eclipsing system, whose spectra shows mostly single peaked Balmer emission lines and a quite intense He II line. There is also the presence of faint (often double peaked) He I emission lines as well as several absorption lines; Mg I being the most prominent. All these features point towards affiliation of this object to the growing number of SW Sex-type objects. We developed a phenomenological model of a SW Sex system to reproduce the observed photometric and spectral features.

  10. Seismic hazard impact of the Lower Tagus Valley Fault Zone (SW Iberia)

    Science.gov (United States)

    Vilanova, Susana P.; Fonseca, Joao F. B. D.

    The seismic hazard of SW Iberia is composed of two contributions: offshore, large to very large events on the plate boundary between Africa and Eurasia such as the Lisbon earthquake of 1755 or the Gorringe Bank earthquake of 1969; and onshore, moderate to strong intraplate earthquakes on inherited crustal fractures. One of these zones of crustal weakness is the Lower Tagus Valley (LTV) fault zone, which displays the highest level of seismic hazard in Western Iberia. In this paper we review the active tectonics and seismicity of the LTV, integrating previous geophysical data with recent results of paleoseismological investigations, and discuss its impact on the seismic hazard of SW Iberia. We conclude that the seismic zonation for hazard assessment currently in force in the building code is biased towards the scenario of distant offshore rupture, and does not take adequately into account the LTV seismic source.

  11. swLORETA: a novel approach to robust source localization and synchronization tomography

    Energy Technology Data Exchange (ETDEWEB)

    Palmero-Soler, Ernesto [Institute for Medicine and Virtual Institute of Neuromodulation, Research Center Juelich, Leo-Brand-Street, 52425 Juelich (Germany); Dolan, Kevin [Institute for Medicine and Virtual Institute of Neuromodulation, Research Center Juelich, Leo-Brand-Street, 52425 Juelich (Germany); Hadamschek, Volker [Institute for Medicine and Virtual Institute of Neuromodulation, Research Center Juelich, Leo-Brand-Street, 52425 Juelich (Germany); Tass, Peter A [Institute for Medicine and Virtual Institute of Neuromodulation, Research Center Juelich, Leo-Brand-Street, 52425 Juelich (Germany)

    2007-04-07

    Standardized low-resolution brain electromagnetic tomography (sLORETA) is a widely used technique for source localization. However, this technique still has some limitations, especially under realistic noisy conditions and in the case of deep sources. To overcome these problems, we present here swLORETA, an improved version of sLORETA, obtained by incorporating a singular value decomposition-based lead field weighting. We show that the precision of the source localization can further be improved by a tomographic phase synchronization analysis based on swLORETA. The phase synchronization analysis turns out to be superior to a standard linear coherence analysis, since the latter cannot distinguish between real phase locking and signal mixing.

  12. Heliotropium thermophilum (Boraginaceae), a new taxon from SW Anatolia, Turkey

    DEFF Research Database (Denmark)

    Tan, Kit; Celik, Ali; Gemici, Yusuf

    2008-01-01

    of its unusual habitat, which is a geothermal area with ground temperatures of 55-65 °C. Affinities clearly lie with the annual H. hirsutissimum Grauer, which is distributed in N Africa, the East Mediterranean area, and SW Asia; the latter, however, is hexaploid (2n = 48) and never occurs in thermal...... habitats. Micromorphological, ecological, and ecophysiological data for the new taxon are provided. Ecological isolation has allowed the evolution and differentiation of a new and distinct species....

  13. Three Dimensional Shallow Water Adaptive Hydraulics (ADH-SW3): Waterborne Vessels

    Science.gov (United States)

    2015-10-01

    SDEF SAILING LINE SEGMENT DEFINITION Field Type Value Description 1 char SDEF Card type 2 int > 0 Vessel number 3 int > 0 Sailing line segment ...upper-right portion of the flume. Figure 2. Angle flume domain. Figure 3. Boat definition parameters (parameters are defined in section “Boundary...CHL CHETN-IV-106 October 2015 6 Figure 8. Galveston Bay ADH-SW3 domain. Figure 9. Boat definition parameters for Galveston Bay vessel

  14. COxSwAIN: Compressive Sensing for Advanced Imaging and Navigation

    Science.gov (United States)

    Kurwitz, Richard; Pulley, Marina; LaFerney, Nathan; Munoz, Carlos

    2015-01-01

    The COxSwAIN project focuses on building an image and video compression scheme that can be implemented in a small or low-power satellite. To do this, we used Compressive Sensing, where the compression is performed by matrix multiplications on the satellite and reconstructed on the ground. Our paper explains our methodology and demonstrates the results of the scheme, being able to achieve high quality image compression that is robust to noise and corruption.

  15. Strangelet search in S-W collisions at 200[ital A] GeV/[ital c

    Energy Technology Data Exchange (ETDEWEB)

    Borer, K.; Dittus, F.; Frei, D.; Hugentobler, E.; Klingenberg, R.; Moser, U.; Pretzl, K.; Schacher, J.; Stoffel, F.; Volken, W. (Laboratory for High Energy Physics, University of Bern, CH-3012 Bern (Switzerland)); Elsener, K.; Lohmann, K.D. (CERN, CH-1211 Geneva (Switzerland)); Baglin, C.; Bussiere, A.; Guillaud, J.P. (Laboratoire de Physique des Particules, CNRS-Institut National de Physique Nucleaire et de Physique des Particules, F-74019 Annecy-le-Vieux (France)); Appelquist, G.; Bohm, C.; Hovander, B.; Sellden, B.; Zhang, Q.P. (Fysikum, Stockholm University, Box 6730, S-113 85 Stockholm (Sweden))

    1994-03-07

    A search for new massive particles with a low charge to mass ratio in S-W collisions at a beam momentum of 200 GeV/[ital c] per nucleon is presented. Upper limits for the production of strangelets with a mass to charge ratio of up to 60 GeV/[ital c][sup 2] at rigidities of [plus minus]150 GV are reported.

  16. Characterisation of [11C]PR04.MZ in Papio anubis baboon: A selective high-affinity radioligand for quantitative imaging of the dopamine transporter

    Energy Technology Data Exchange (ETDEWEB)

    Riss P. J.; Fowler J.; Riss, P.J.; Hooker, J.M.; Shea, C.; Xu, Y.; Carter, P.; Warner, D.; Ferrari V.; Kim, S.W.; Aigbirhio, F.I.; Fowler, J.S.; Roesch, F.

    2011-10-25

    N-(4-fluorobut-2-yn-1-yl)-2{beta}-carbomethoxy-3{beta}-(4{prime}-tolyl)nortropane (PR04.MZ, 1) is a PET radioligand for the non-invasive exploration of the function of the cerebral dopamine transporter (DAT). A reliable automated process for routine production of the carbon-11 labelled analogue [{sup 11}C]PR04.MZ ([{sup 11}C]-1) has been developed using GMP compliant equipment. An adult female Papioanubis baboon was studied using a test-retest protocol with [{sup 11}C]-1 in order to assess test-retest reliability, metabolism and CNS distribution profile of the tracer in non-human primates. Blood sampling was performed throughout the studies for determination of the free fraction in plasma (fP), plasma input functions and metabolic degradation of the radiotracer [{sup 11}C]-1. Time-activity curves were derived for the putamen, the caudate nucleus, the ventral striatum, the midbrain and the cerebellum. Distribution volumes (VT) and non-displaceable binding potentials (BPND) for various brain regions and the blood were obtained from kinetic modelling. [{sup 11}C]-1 shows promising results as aselective marker of the presynaptic dopamine transporter. With the reliable visualisation of the extra-striatal dopaminergic neurons and no indication on labelled metabolites, the tracer provides excellent potential for translation into man.

  17. Computer Simulation of Single-Well Steam Assisted Gravity Drainage (SW-SAGD), SUPRI TR-119

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, Keith T.; Kovscek, Anthony R.

    1999-08-09

    Steam assisted gravity drainage (SAGD) is an effective method of producing heavy oil and bitumen. In a typical SAGD approach, steam is injected into a horizontal well located directly above a horizontal producer. A steam chamber grows around the injection well and helps displace heated oil toward the production well. Single-well (SW) SAGD attempts to create a similar process using only one horizontal well. This may include steam injection from the toe of the horizontal well with production at the heel. Obvious advantages of SW-SAGD include cost savings and utility in relatively thin reservoirs. However, the process is technically challenging. To improve early-time response of SW-SAGD, it is necessary to heat the near-wellbore area to reduce oil viscosity and allow gravity drainage to take place. Ideally heating should occur with minimal circulation or bypassing of stream. Since project economics are sensitive to early production response, we are interested in optimizing the start -up procedure.

  18. The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine

    Directory of Open Access Journals (Sweden)

    Goedegebuure Peter

    2010-11-01

    Full Text Available Abstract Background Sigma-2 receptors are over-expressed in proliferating cancer cells, making an attractive target for the targeted treatment of pancreatic cancer. In this study, we investigated the role of the novel sigma-2 receptor ligand SW43 to induce apoptosis and augment standard chemotherapy. Results The binding affinity for sigma-2 ligands is high in pancreas cancer, and they induce apoptosis with a rank order of SV119 in vitro. Combining these compounds with gemcitabine further increased apoptosis and decreased viability. Our in vivo model showed that sigma-2 ligand treatment decreased tumor volume to the same extent as gemcitabine. However, SW43 combination treatment with gemcitabine was superior to the other compounds and resulted in stabilization of tumor volume during treatment, with minimal toxicities. Conclusions This study shows that the sigma-2 ligand SW43 has the greatest capacity to augment gemcitabine in a pre-clinical model of pancreas cancer and has provided us with the rationale to move this compound forward with clinical investigations for patients with pancreatic cancer.

  19. Zircon LA-ICPMS geochronology of the Cornubian Batholith, SW England

    Science.gov (United States)

    Neace, Erika R.; Nance, R. Damian; Murphy, J. Brendan; Lancaster, Penelope J.; Shail, Robin K.

    2016-06-01

    Available Usbnd Pb age data for the Cornubian Batholith of SW England is based almost entirely on monazite and xenotime, and very little zircon Usbnd Pb age data has been published. As a result, no zircon inheritance data is available for the batholith, by which the nature of the unexposed basement of the Rhenohercynian Zone in SW England might be constrained. Zircon LA-ICPMS data for the Cornubian Batholith provides Concordia ages (Bodmin Moor granite: 316 ± 4 Ma, Carnmenellis granite: 313 ± 3 Ma, Dartmoor granite: ~ 310 Ma, St. Austell granite: 305 ± 5 Ma, and Land's End granite: 300 ± 5 Ma) that are consistently 20-30 Ma older than previously published emplacement ages for the batholith and unrealistic in terms of geologic relative age relationships with respect to the country rock. This discrepancy is likely as a consequence of minor pre-granitic Pb inheritance. Several of the batholith's granite plutons contain a component of late-Devonian inheritance that may record rift-related, lower crustal melting or arc-related magmatism associated with subduction of the Rheic Ocean. In addition, the older granites likely contain Mesoproterozoic inheritance, although the highly discordant nature of the Mesoproterozoic ages precludes their use in assigning an affinity to the Rhenohercynian basement in SW England.

  20. γ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells.

    Directory of Open Access Journals (Sweden)

    Jing-Shu Zhang

    Full Text Available Colorectal cancer is one of the most serious illnesses among diagnosed cancer. As a new type of anti-cancer composition from tocotrienol-rich fraction of palm oil, γ-tocotrienol is widely used in anti-cancer research. The objectives of this study were to investigate the effects of γ-tocotrienol on human colon cancer SW620 and HCT-8 cells. We showed that treatment with different concentrations of γ-tocotrienol resulted in a dose dependent inhibition of cell growth. Cell death induced by γ-tocotrienol was mediated by a paraptosis-like cell death in SW620 and HCT-8 cells. Real-time RT-PCR and western blot analyses showed that γ-tocotrienol inhibited the expression level of β-catenin, cyclin D1 and c-jun. These data suggest that a paraptosis-like cell death induced by γ-tocotrienol in SW620 cells is associated with the suppression of the Wnt signaling pathway, which offers a novel tool for treating apoptosis-resistance colon cancer.

  1. HMGB1-mediated autophagy decreases sensitivity to oxymatrine in SW982 human synovial sarcoma cells.

    Science.gov (United States)

    Cai, Yongsong; Xu, Peng; Yang, Le; Xu, Ke; Zhu, Jialin; Wu, Xiaoqing; Jiang, Congshan; Yuan, Qiling; Wang, Bo; Li, Yuanbo; Qiu, Yusheng

    2016-11-29

    Oxymatrine (OMT) is a type of alkaloid extracted from a traditional Chinese medicinal herb, Sophora flavescens. Although the antitumor activities of OMT have been observed in various cancers, there are no reports regarding the effects of OMT on human synovial sarcoma. In the present study, we analyzed the antitumor activities of OMT in SW982 human synovial sarcoma cells and determine whether high mobility group box protein 1 (HMGB1)-mediated autophagy was associated with its therapeutic effects. We found that OMT exhibited antitumor activity in SW982 cells and facilitated increases in autophagy. Inhibition of autophagy by 3-MA or ATG7 siRNA increased the level of apoptosis, which indicated that OMT-induced autophagy protected cells from the cytotoxicity of OMT. Administration of OMT to SW982 cells increased the expression of HMGB1. When HMGB1 was inhibited via HMGB1-siRNA, OMT-induced autophagy was decreased, and apoptosis was increased. Furthermore, we found that HMGB1-siRNA significantly increased the expression of p-Akt and p-mTOR. OMT-induced autophagy may be mediated by the Akt/mTOR pathway, and HMGB1 plays a vital role in the regulation of autophagy. Therefore, we believe that combining OMT with an inhibitor of autophagy or HMGB1 may make OMT more effective in the treatment of human synovial sarcoma.

  2. Airborne Quercus pollen in SW Spain: Identifying favourable conditions for atmospheric transport and potential source areas.

    Science.gov (United States)

    Maya-Manzano, José María; Fernández-Rodríguez, Santiago; Smith, Matt; Tormo-Molina, Rafael; Reynolds, Andrew M; Silva-Palacios, Inmaculada; Gonzalo-Garijo, Ángela; Sadyś, Magdalena

    2016-11-15

    The pollen grains of Quercus spp. (oak trees) are allergenic. This study investigates airborne Quercus pollen in SW Spain with the aim identifying favourable conditions for atmospheric transport and potential sources areas. Two types of Quercus distribution maps were produced. Airborne Quercus pollen concentrations were measured at three sites located in the Extremadura region (SW Spain) for 3 consecutive years. The seasonal occurrence of Quercus pollen in the air was investigated, as well as days with pollen concentrations ≥80Pm(-3). The distance that Quercus pollen can be transported in appreciable numbers was calculated using clusters of back trajectories representing the air mass movement above the source areas (oak woodlands), and by using a state-of-the-art dispersion model. The two main potential sources of Quercus airborne pollen captured in SW Spain are Q. ilex subsp. ballota and Q. suber. The minimum distances between aerobiological stations and Quercus woodlands have been estimated as: 40km (Plasencia), 66km (Don Benito), 62km (Zafra) from the context of this study. Daily mean Quercus pollen concentration can exceed 1,700Pm(-3), levels reached not less than 24 days in a single year. High Quercus pollen concentration were mostly associated with moderate wind speed events (6-10ms(-1)), whereas that a high wind speed (16-20ms(-1)) seems to be associated with low concentrations.

  3. Antibiofilm activity of Bacillus pumilus SW9 against initial biofouling on microfiltration membranes.

    Science.gov (United States)

    Zhang, Ying; Yu, Xin; Gong, Song; Ye, Chengsong; Fan, Zihong; Lin, Huirong

    2014-02-01

    Membrane biofouling, resulting from biofilm formation on the membrane, has become the main obstacle hindering wider application of membrane technology. Initial biofouling proves to be crucial which involves early stages of microbial adhesion and biofilm formation. Biological control of microbial attachment seems to be a promising strategy due to its high efficiency and eco-friendliness. The present study investigated the effects of a bacterium Bacillus pumilus SW9 on controlling the initial fouling formed by four target bacterial strains which were pioneer species responsible for biofouling in membrane bioreactors, using microfiltration membranes as the abiotic surfaces. The results suggested that strain SW9 exhibited excellent antibiofilm activity by decreasing the attached biomass of target strains. The production of extracellular polysaccharides and proteins by four target strains was also reduced. A distinct improvement of permeate flux in dead-end filtration systems was achieved when introducing strain SW9 to microfiltration experiments. Scanning electron microscopy and confocal laser scanning microscopy were performed to further ascertain significant changes of the biofouling layers. A link between biofilm inhibition and initial biofouling mitigation was thus provided, suggesting an alternatively potential way to control membrane biofouling through bacterial interactions.

  4. Cretaceous to Quaternary Siliciclastic Sediments of the Tarfaya Basin, Marginal Atlantic, SW Morocco Petrography, Geochemistry, Provenance, Climate and Weathering

    OpenAIRE

    Ali, Sajid

    2012-01-01

    This dissertation is prepared to attain the doctorate under the title "Cretaceous to Quaternary Siliciclastic Sediments of the Tarfaya Basin, Marginal Atlantic, SW Morocco Petrography, Geochemistry, Provenance, Climate and Weathering".

  5. 番茄红素诱导人结肠癌SW480细胞凋亡的作用机制%Mechanism of Lycopene Induced Cell Apoptosis on Human Colon Cancer SW480 Cells

    Institute of Scientific and Technical Information of China (English)

    赵其辉; 邱青朝; 胡波

    2012-01-01

    Objective To investigate the effect of Lycopene on the apoptosis of human colon cancer SW480 cells and the relevant molecular mechanism. Methods The anti-proliferative effect of a different concentration of Lycopene on SW480 cells was measured by MTT assay. Ratio of SW480 cells apoptosis was analyzed by flow cy-tometry. The levels of Bcl-2,Bax were detected by RT-PCR and Western blot. The expression levels of Caspase-9 and Caspase-3 were analyzed by Western blot. Results The MTT assay showed that Lycopene had potent anti-proliferative effect on SW480 cells in a time- and dose-dependent manner. The IC50 value of Lycopene was SW480 cells treated with 1. 0 μmol/L Lycopene for 24 hours. Flow cytometry analysis revealed that Lycopene increased the percentage of apoptotic SW480 cells. The expression level of Bcl-2 were decreased, while the expression levels of Bax,Caspase-9 and Caspase-3 were increased significantly in SW480 cells treated with different concentrations of Lycopene. Conclusion Lycopene could induce apoptosis of SW480 cells by decreasing the ratio of Bcl-2/Bax and increasing Caspase-9 and Caspase-3 expression.%目的 探讨番茄红素诱导人结肠癌SW480细胞凋亡的分子机制.方法 体外培养SW480细胞,采用MTT比色实验、流式细胞术、RT PCR和Western blot方法,分析番茄红素对SW480细胞的生长增殖作用、对细胞凋亡率的影响及对细胞凋亡相关分子Bcl-2、Bax、Caspase-9和Caspase-3表达的影响.结果 MTT法显示,番茄红素能显著抑制SW480细胞的生长增殖能力,且呈一定的量效与时效关系,24 h的半数抑制浓度(IC50)为1.0 μmol/L;流式细胞仪分析表明,番茄红素呈浓度依赖性诱导SW480细胞凋亡;RT PCR或Western blot分析表明,SW480细胞经不同浓度番茄红素诱导后,与溶媒组相比,Bcl-2表达逐渐减弱,而Bax,Caspase-9和Caspase-3表达逐渐增强,Bcl-2/Bax比值降低.结论 番茄红素对SW480细胞的抑制增殖作用,可能与降低Bcl-2/Bax

  6. The Characteristics of Seismogenic Zones in SW Taiwan: Implications from Studying Mechanisms of Microearthquakes

    Science.gov (United States)

    Wen, Strong; Chang, Yi-Zen; Yeh, Yu-Lien; Wen, Yi-Ying

    2017-04-01

    Due to the complicated geomorphology and geological conditions, the southwest (SW) Taiwan suffers the invasion of various natural disasters, such as landslide, mud flow and especially the threat of strong earthquakes as result of convergence between the Eurasian and the Philippine Sea plate. Several disastrous earthquakes had occurred in this area and often caused serious hazards. Therefore, it is fundamentally important to understand the correlation between seismic activity and seismogenic structures in SW Taiwan. Previous studies have indicated that before the failure of rock strength, the behaviors of micro-earthquakes can provide essential clues to help investigating the process of rock deformation. Thus, monitoring the activity of micro-earthquakes plays an important role in studying fault rupture or crustal deformation before the occurrence of a large earthquake. Because the time duration of micro-earthquakes activity can last for years, this phenomenon can be used to indicate the change of physical properties in the crust, such as crustal stress changes or fluid migration. The main purpose of this research is to perform a nonlinear waveform inversion to investigate source parameters of micro-earthquakes which include the non-double couple components owing to the shear rupture usually associated with complex morphology as well as tectonic fault systems. We applied a nonlinear waveform procedure to investigate local stress status and source parameters of micro-earthquakes that occurred in SW Taiwan. Previous studies has shown that microseismic fracture behaviors were controlled by the non-double components, which could lead to cracks generating and fluid migration, which can result in changing rock volume and produce partial compensation. Our results not only giving better understanding the seismogenic structures in the SW Taiwan, but also allowing us to detect variations of physical parameters caused by crack propagating in stratum. Thus, the derived source

  7. A Multiwavelength Study of the Relativistic Tidal Disruption Candidate Sw J2058+05 at Late Times

    CERN Document Server

    Pasham, Dheeraj R; Levan, Andrew J; Bower, Geoffrey C; Horesh, Assaf; Brown, Gregory C; Dolan, Stephen; Wiersema, Klaas; Filippenko, Alexei V; Fruchter, Andrew S; Greiner, Jochen; Hounsell, Rebekah A; O'Brien, Paul T; Page, Kim L; Rau, Arne; Tanvir, Nial R

    2015-01-01

    ${\\it Swift}$ J2058.4+0516 (Sw J2058+05, hereafter) has been suggested as the second member (after Sw J1644+57) of the rare class of tidal disruption events accompanied by relativistic ejecta. Here we report a multiwavelength (X-ray, ultraviolet/optical/infrared, radio) analysis of Sw J2058+05 from 3 months to 3 yr post-discovery in order to study its properties and compare its behavior with that of Sw J1644+57. Our main results are as follows. (1) The long-term X-ray light curve of Sw J2058+05 shows a remarkably similar trend to that of Sw J1644+57. After a prolonged power-law decay, the X-ray flux drops off rapidly by a factor of $\\gtrsim 160$ within a span of $\\Delta$$t$/$t$ $\\le$ 0.95. Associating this sudden decline with the transition from super-Eddington to sub-Eddington accretion, we estimate the black hole mass to be in the range of $10^{4-6}$ M$_{\\odot}$. (2) We detect rapid ($\\lesssim 500$ s) X-ray variability before the dropoff, suggesting that, even at late times, the X-rays originate from close ...

  8. Virosecurinine induces apoptosis by affecting Bcl-2 and Bax expression in human colon cancer SW480 cells.

    Science.gov (United States)

    Chen, Chuan-Rong; Xia, Yong-Hui; Yao, Shu-Yan; Zhang, Qing; Wang, Ying; Ji, Zhao-Ning

    2012-04-01

    Virosecurinine, the major alkaloid isolated from Securinega suffruticosa Pall Rehd was found to exhibit growth inhibition and cytotoxicity against huaman colon cancer SW480 cells via the microculture tetrazolium (MTT) assay. Due to its greater cytotoxic potency and selectivity towards SW480 cells, flow cytometry was used to analyze the cell cycle distribution of control and treated SW480 cells whereas Annexin V-FITC/PI flow cytometry analysis was carried out to confirm apoptosis induced by virosecurinine in SW480 cells. Apoptotic regulatory genes were determined by RT-PCR analysis. Virosecurinine was found to induce G1/S cell cycle arrest which led to predominantly apoptotic mode of cell death. Mechanistically, virosecurinine was found to up-regulated the Bax gene expression and down-regulated the Bcl-2 expression in SW480, The ratio of Bcl-2 to Bax was significantly decreased. Hence, we suggest that virosecurinine induced apoptosis in SW480 cells by affecting the expression of bcl-2 and bax.

  9. Development of a locus-specific, co-dominant SCAR marker for assisted-selection of the Sw-5 (Tospovirus resistance) gene cluster in a wide range of tomato accessions

    NARCIS (Netherlands)

    Dianese, E.C.; Fonseca, M.E.N.; Goldbach, R.W.; Kormelink, R.J.M.; Inoue-Nagata, A.K.; Resende, de R.O.; Boiteux, L.S.

    2010-01-01

    The best levels of broad-spectrum Tospovirus resistance reported in tomatoes thus far are conferred by the Sw-5 locus. This locus contains at least five paralogues (denoted Sw-5a through Sw-5e), of which Sw-5b represents the actual resistance gene. Here we evaluated a panel of seven PCR primer pairs

  10. Neotectonic fault detection and lithosphere structure beneath SW of High Atlas (Morocco)

    Science.gov (United States)

    Timoulali, Youssef; Radi, Said; Azguet, Roumaissae; Bachaoui, Mostapha

    2016-08-01

    The High Atlas is a 100 km wide zone defined by E-W to NE-SW trending folds nearly orthogonal to the Atlantic coastline. The major compressional structures in the High Atlas consist of large-scale fold systems which affect Mesozoic and Cainozoic formations. The extreme West of the High Atlas including the region of Agadir is defined as an earthquake Zone. Historical seismicity data shows that the Agadir region was hit by two destructive earthquakes in 1731 and 1960 with magnitude 6.4 and 6.0, respectively. The present study has two main goals: 1) to use remote sensing techniques to detect and map the surface geological structures including faults; 2) to use the local earthquake tomography for imaging the lithosphere (subsurface) and detect deep structures. For the remote sensing techniques we used ETM + Landsat7 images and the SRTM 90 m image as a Digital Terrane Elevation Model. This study focuses on the computerized identification, feature extraction and quantitative interpretation of lineaments over the SW High Atlas. The analysis developed here is based on the numerical enhancement of a Landsat image and on the statistical processing of data generated through enhancement. The results generated by the numerical enhancement and statistical analysis are presented on fault maps, lineament maps, polar diagrams and lineament density maps. The lineaments have a high concentration of orientations around the directions N40E, N80W and N-S. For the subsurface study, seismic data sets were used to define the 3-D velocity structures. We also used local earthquake tomography to obtain the velocity map and crustal structure of the SW High Atlas region. The tomography results show a new and detailed lithosphere structure defined by a high velocity body in the northern of SW High Atlas from 15 to 45 Km depth, dipping to the north beneath the Essaouira basin in the western Meseta with P velocity variations from 6.5 to 7.8 km/s. This anomaly can be interpreted as an old

  11. Development of a locus-specific, co-dominant SCAR marker for assisted-selection of the Sw-5 (Tospovirus resistance) gene cluster in a wide range of tomato accessions

    OpenAIRE

    DIANESE, E. de C.; Fonseca, M.E.N.; Goldbach, R W; Kormelink, R.J.M.; Inoue-Nagata, A.K.; Resende, MR; BOITEUX, L. S.

    2010-01-01

    The best levels of broad-spectrum Tospovirus resistance reported in tomatoes thus far are conferred by the Sw-5 locus. This locus contains at least five paralogues (denoted Sw-5a through Sw-5e), of which Sw-5b represents the actual resistance gene. Here we evaluated a panel of seven PCR primer pairs matching different sequences within a genomic region spanning the Sw-5a and Sw-5b gene cluster. Primer efficiency evaluation was done employing tomato isolines with and without the Sw-5 locus. One...

  12. EFFECTS OF HYDROXYCAMPTOTHECIN ON THE MIGRATION OF HUMAN ADRENOEORTICAL CARCINOMA CELL LINE SW-13%羟喜树碱对人肾上腺皮质癌SW-13细胞迁移的影响

    Institute of Scientific and Technical Information of China (English)

    吴峰萍张劼通讯; 罗佐杰文静梁杏欢

    2013-01-01

    Objective To investigate the effects of HCPT on the migration of human adrenoeortical carcinoma cel line SW-13.Method SW-13 cel were culutured and the same cels were studied,which were randomly divided into there groops:The 0.8ug/mlHCPT intervention group and negative control group. The migration ability of SW-13 was measured by non-migration area.The size of the non-migration area was photographed at 0,48h and analyzed with the Image pro plus 6 software.Results At 48 hour, the non-migration area percentage in the experimental group were larger than negative Control .Conlusions HCPT could inhibit the migration ability of SW-13 cels. Objective To investigate the effects of HCPT on the migration of human adrenoeortical carcinoma cel line SW-13.Method SW-13 cel were culutured and the same cels were studied,which were randomly divided into there groops:The 0.8ug/mlHCPT intervention group and negative control group. The migration ability of SW-13 was measured by non-migration area.The size of the non-migration area was photographed at 0,48h and analyzed with the Image pro plus 6 software.Results At 48 hour, the non-migration area percentage in the experimental group were larger than negative Control .Conlusions HCPT could inhibit the migration ability of SW-13 cels.%  目的:观察羟喜树碱对人肾上腺皮质癌SW-13细胞迁移的影响。方法:体外培养人肾上腺皮质癌SW-13细胞,取对数生长期细胞(同一代)进行实验,随机分为羟喜树碱干预组和对照组,干预组加入0.8ug/ml羟喜树碱。细胞划痕试验观察SW-13细胞的体外迁移力,分别在0h、48h拍照观察,应用Image pro plus 6软件处理分析结果。结果:1、光镜下可见羟喜树碱干预组SW-13细胞未迁移面积大于对照组;2、羟喜树碱干预组SW-13细胞的未迁移率大于对照组(P=0.000)。结论:羟喜树碱有可能降低人肾上腺皮质癌SW-13细胞侵袭、迁移的能力。

  13. Functional characterization of a novel lytic phage EcSw isolated from Sus scrofa domesticus and its potential for phage therapy.

    Science.gov (United States)

    Easwaran, Maheswaran; Paudel, Sarita; De Zoysa, Mahanama; Shin, Hyun-Jin

    2015-06-01

    In this study, multi-drug resistant Escherichia coli Sw1 (E. coli Sw1) and active lytic phage EcSw was isolated from feces samples of Sus scrofa domesticus (piglet) suffering from diarrhea. Transmission electron microscopy (TEM) indicated that isolated EcSw belongs to the Myoviridae family with an icosahedral head (80 ± 4) and a long tail (180 ± 5 nm). The EcSw phage genome size was estimated to be approximately 75 Kb of double-stranded DNA (dsDNA). Phage dynamic studies show that the latent period and burst size of EcSw were approximately 20 min and 28 PFU per cell, respectively. Interestingly, the EcSw phage can tolerate a wide range of environmental conditions, such as temperature, pH and ions (Ca(2+) and Mg(2+)). Furthermore, genome sequence analysis revealed that the lytic genes of the EcSw phage are notably similar to those of enterobacteria phages. In addition, phage-antibiotic synergy has notable effects compared with the effects of phages or antibiotics alone. Inhibition of E. coli Sw1 and 0157:H7 strains showed that the limitations of host specificity and infectivity of EcSw. Even though, it has considerable potential for phage therapy for handling the problem of the emergence of multidrug resistant pathogens.

  14. Comparison of chest compression quality between the modified chest compression method with the use of smartphone application and the standardized traditional chest compression method during CPR.

    Science.gov (United States)

    Park, Sang-Sub

    2014-01-01

    The purpose of this study is to grasp difference in quality of chest compression accuracy between the modified chest compression method with the use of smartphone application and the standardized traditional chest compression method. Participants were progressed 64 people except 6 absentees among 70 people who agreed to participation with completing the CPR curriculum. In the classification of group in participants, the modified chest compression method was called as smartphone group (33 people). The standardized chest compression method was called as traditional group (31 people). The common equipments in both groups were used Manikin for practice and Manikin for evaluation. In the meantime, the smartphone group for application was utilized Android and iOS Operating System (OS) of 2 smartphone products (G, i). The measurement period was conducted from September 25th to 26th, 2012. Data analysis was used SPSS WIN 12.0 program. As a result of research, the proper compression depth (mm) was shown the proper compression depth (psmartphone group (48.35 mm). Even the proper chest compression (%) was formed suitably (psmartphone group (60.51%). As for the awareness of chest compression accuracy, the traditional group (3.83 points) had the higher awareness of chest compression accuracy (psmartphone group (2.32 points). In the questionnaire that was additionally carried out 1 question only in smartphone group, the modified chest compression method with the use of smartphone had the high negative reason in rescuer for occurrence of hand back pain (48.5%) and unstable posture (21.2%).

  15. Cloud effects on the SW radiation at the surface at a mid-latitude site in southwestern Europe

    Science.gov (United States)

    Salgueiro, Vanda; João Costa, Maria; Silva, Ana Maria; Lanconelli, Christian; Bortoli, Daniele

    2017-04-01

    This work presents a study of cloud radiative effects on shortwave (CRESW) radiation at the surface in Évora region (southwestern Europe) during 2015 and a case study is analyzed. CRESW (in Wm-2) is defined as the difference between the net shortwave irradiance (downward minus upward shortwave irradiance) in cloudy and clear sky conditions. This measure is usually used to translate changes in the SW radiation that reaches the surface due to changes in clouds (type and/or cover). The CRESW is obtained using measured SW irradiance recorded with a Kipp&Zonen CM 6B pyranometer (broadband 305 - 2800 nm) during the period from January to December 2015, and is related with the cloud liquid water path (LWP) and with cloud ice water path (IWP) showing the importance of the different type of clouds in attenuating the SW radiation at the surface. The cloud modification factor, also a measure of the cloud radiative effects (CMF; ratio between the measured SW irradiance under cloudy conditions and the estimated SW irradiance in clear-sky conditions) is related with the cloud optical thickness (COT; obtained from satellite data). This relation between CMF and COT is shown for different cloud fractions revealing an exponential decreasing of CMF as COT increases. Reductions in the SW radiation of the order of 80% (CMF = 0.2) as well enhancements in the SW radiation larger than 30% (CMF = 1.3) were found for small COT values and for different cloud fractions. A case study to analyse the enhancement events in a cloudy day was considered and the cloud properties, COT and LWP (from satellite and surface measurements), were related with the CRESW.

  16. Investigating migration inhibition and apoptotic effects of Fomitopsis pinicola chloroform extract on human colorectal cancer SW-480 cells.

    Directory of Open Access Journals (Sweden)

    Yaqin Wang

    Full Text Available BACKGROUND: Fomitopsis pinicola (Sw. Ex Fr.m Karst (FPK which belongs to the Basidiomycota fungal class is one of the most popular medical fungi in China. It has been used for many diseases: cancer, heart diseases, diabetes and so on. However, little study on the pro-apoptotic effect and migration inhibition of FPK chloroform extract (FPKc has been reported and the possible involved mechanism has not been illuminated. METHODOLOGY/PRINCIPAL FINDINGS: Chemical analysis was performed by HPLC which showed ergosterol (ES concentration was 105 µg/mg. MTT assay revealed that FPKc could selectively inhibit SW-480 cells viability with the IC50 of 190.28 µg/ml. Wound healing and transwell assay indicated that FPKc could inhibit the migration of SW-480 cells obviously, FPKc could also dramatically decreased the matrix metalloproteinases-2, 9 (MMP-2 and MMP-9 expression. Annexin V-FITC/PI staining, nuclear Hoechst 33342 staining and DNA fragmentation analysis revealed that FPKc and ES could induce SW-480 cells apoptosis. The apoptosis process closely involved in ROS accumulation and depletion of GSH, activation of caspase 3, poly (ADP-ribose polymerase (PARP degradation. FPKc could also up-regulate P53 expression and thus lead to G1 phase arrest. When SW-480 cells were pretreated with N-acetylcysteine (NAC, the ROS generation, cell viability and apoptotic ratio were partially declined, which indicated that ROS was vertical in the pro-apoptosis process induced by FPKc. Moreover, in the whole process, ES which has been previously found in FPKc had the similar effect to FPKc. Thus we could conclude that ES, as one of the highest abundant components in FPKc, might also be one of the active constituents. CONCLUSION/SIGNIFICANCE: FPKc could inhibit the migration of SW-480 cells, induce SW-480 cells G1 phase arrest and cause ROS-mediated apoptosis effect. And ES might be one of the effective constituents in the whole process.

  17. Late Cenozoic stress state distributions at the intersection of the Hellenic and Cyprus Arcs, SW Turkey

    Science.gov (United States)

    Över, Semir; Özden, Süha; Pınar, Ali; Yılmaz, Hüseyin; Kamacı, Züheyr; Ünlügenç, Ulvi Can

    2016-12-01

    The history of the Late Cenozoic stress regime was determined for an area between the gulfs of Fethiye and Antalya. Fault kinematic analysis and inversion of focal mechanisms of shallow earthquakes reveal significant evolution of the regional stress regime in SW Anatolia, i.e., the area of interaction between the Hellenic and Cyprus arcs, from the Mio-Pliocene to the present time. Fault kinematic analysis yields two different normal faulting stress regimes along the southwestern part of Fethiye-Burdur Fault zone, e.g., in and around Çameli Basin (Zone A1) and two different strike-slip to normal faulting stress regimes characterized by a roughly orthogonal set of extensional axes between Fethiye and Demre (Zone B) with an older NW-SE σ3 axis for Mio-Pliocene and a younger NE-SW σ3 axis for Plio-Quaternary time. Inversion of focal mechanisms of the earthquakes occurring in Zone A1 provides an extensional stress state with approximately N-S σ3 axis. Inversion of those occurring in Zone B, south of Zone A1, yields a dominantly strike-slip stress state with a NE-SW σ3 axis and a NW-SE σ1 axis respectively. The inversion slip vectors from fault planes yield a consistent normal faulting stress regime in Burdur Basin and its surroundings (i.e., along the northeastern part of Fethiye-Burdur Fault Zone, (Zone A2)) during Plio-Quaternary, continuing into recent time as indicated by earthquake focal mechanism inversions. Both states have a consistent NW-SE σ3 axis. Fault kinematic analysis indicates NW-SE extension acting in Zone C (subarea between Demre and Antalya), south of Zone A2, during Mio-Pliocene time. The inversion of focal mechanisms yields normal faulting also characterized by a consistent NW-SE σ3 axis. The nearly orthogonal extensional stress regimes (NW-SE and NE-SW) obtained by inversion of both measured and seismic faults seem to have been acting contemporaneously with each other at different intensities from the Mio-Pliocene onwards in SW Turkey. This

  18. 芝麻素对人结肠癌SW480细胞株的影响%The effect of sesamin on human’s colon cancer SW480 cells

    Institute of Scientific and Technical Information of China (English)

    孙方博; 白金权; 王瑶; 赵斌; 佟瑶瑶; 张晓霞

    2015-01-01

    目的探讨芝麻素对人结肠癌 SW480细胞株的作用及机制。方法 MTT 比色法检测芝麻素对SW480增殖抑制率的变化,确定半数抑制浓度( IC50);倒置显微镜下观察芝麻素作用SW480后形态学变化;流式细胞术行Annexin-FITC/PI 双染法检测细胞早期凋亡率;通过免疫细胞化学染色方法观察 caspase-3和caspase-8的表达。结果芝麻素作用SW480产生增殖抑制现象;镜下观察芝麻素作用SW480使其体积缩小,皱缩变圆,贴壁不牢,视野中细胞凋亡明显;芝麻素组与对照组相比细胞早期凋亡率具有统计学意义,( P <0.01);芝麻素作用SW480后caspase-3和caspase-8的表达较对照组显著,具有统计学意义,(P<0.01)。结论芝麻素作用人结肠癌SW480细胞株呈现出增殖抑制作用,具有浓度依赖性;增值抑制作用的机制可能与激活caspase家族成员有关。%Objective To investigate the effect of Sesamin on human’s colon cancer SW480 cells and its mechanism. Methods MTT colorimetry was employed to determine the median inhibitory concentration ( IC50 ) and observe the influence of Sesamin on SW480 cells’ proliferation. SW480’s morphological changes were observed under the micro-scope. Annexin-FITC/PI double staining was used to detect the cells’ apoptosis rate. The expression of caspase-3 and caspase-8 were observed by the immunohistochemical staining. Results Seatrain inhibited the proliferation of SW480;SW480'volume shrinks and becomes round,while the phenomenon of apoptosis was clear. Compared with the control group,the Sesamin group’s early apoptosis rate is statistically significant (P <0. 01) and the expression of caspase-3 and caspase-8 was more significant ( P <0 . 01 ) . Conclusion Sesamin could inhibit the proliferation of SW480 in a dose-depend manner and its mechanism may be concerned in the activation of caspase family members.

  19. 冬凌草甲素对胰腺癌SW1990细胞的抑制作用及机制%Inhibiting effect of oridonin on human pancreatic cancer cell line SW1990 and its mechanism

    Institute of Scientific and Technical Information of China (English)

    王文兰; 付彩文; 付文浩; 柳树芳; 王姝莲; 程三芳

    2015-01-01

    目的:探讨冬凌草甲素对人胰腺癌SW1990细胞增殖的抑制作用及其作用机制。方法以10、20、40μmol/L不同浓度冬凌草甲素( Ori)作用于胰腺癌SW1990细胞,采用CCK-8检测胰腺癌SW1990细胞增殖情况;流式细胞仪检测细胞周期及凋亡情况;RT-PCR法检测Survivin、p21基因mRNA表达水平。结果不同浓度的Ori作用于胰腺癌SW1990细胞1、2、3 d后,胰腺癌SW1990细胞增殖抑制程度不等,药物浓度越高,抑制程度越高,两者间具有明显剂量与时间依赖性。0、10、20、40μmol/L的冬凌草甲素作用于胰腺癌SW1990细胞24 h后,凋亡率分别为0.87%±0.65%、1.85%±1.02%、5.38%±0.15%和16.60%±0.50%,出现明显的G2/M期周期阻滞。与对照组相比,10、20、40μmol/L的Ori作用于SW1990细胞24 h后,p21 mRNA表达增加,而Survivin mRNA表达下降。结论冬凌草甲素通过诱导凋亡和G2/M期周期阻滞来实现对胰腺癌SW1990细胞增殖的抑制作用,其机制可能与Survivin和p21调节信号有关。%Objective To investigate the inhibit effect of oridonin on human pancreatic cancer cell line SW1990 and its mechanism. Methods SW1990 cells were induced with different concentrations (10,20,40 μmol/L) of oridonin,the proliferation of SW1990 cells were detected by CCK-8;cell cycle and apoptosis were measured by flow cytometry; RT-PCR assay was used to detect the expression level of survivin and p21 gene mRNA. Results Different concentrations of oridonin inhibited SW1990 cells proliferation in a time-and dose-dependent manner after 1d,2 d,3 d. Oridonin at 0,10,20,40 μmol/L caused obvious cell cycle arrest in G2/M phase,and 24 h apoptosis rate were 0. 87%± 0. 65%、1. 85% ± 1. 02%,5. 38% ± 0. 15% and 16. 60% ± 0. 50%. Compared with control group,p21 mRNA ex-pression increased,while Survivin mRNA expression decreased. Conclusion Oridonin inhibits SW1990 cells prolifera-tion by inducing apoptosis and arresting G2/M phase cycle

  20. High-resolution seafloor features related to potential gas-hydrate formation off SW Taiwan

    Science.gov (United States)

    Hsu, S.; Tsai, C.; Chen, S.; Shih, T.

    2010-12-01

    The area off SW Taiwan is considered as a high potential area for gas-hydrate formation. The gas-hydrate signature is indicated by the abundant presence of BSR (Bottom-Simulating-Reflector). High methane concentration is also shown in the bottom water near the seafloor. To have a better understanding, we have conducted deep-towed survey of side-scan sonar and sub-bottom profiler in several potential areas. Pockmarks are found in several places. Some are related to gas seeping. The gas seeps are especially obvious in high-resolution sub-bottom profilers. The high pore-pressure due to the charging of the gas has clearly uplifted a top layer of sediments. The pockmarks area usually accompany the presence of authigenic carbonate. In the image of side-scan sonar data, the irregular patterns of strong backscatter signal are associated with the gas seeping or pockmark sites. The presence of pockmarks or gas seeps could be related to structural faults. Because the NW convergence of the Philippine Sea plate relative to the Eurasian plate, the area off SW Taiwan in fact is under compression and has caused folds and faults. These structural faults provide efficient conduits for fluid to migrate upward. Thus, the pockmarks frequently appear near faults. In the water depth of about 450m, the upward gas even goes into water column and creates clear gas plume image in EK 500 data. The gas is inferred to be dissociated from gas-hydrate and can get into the atmosphere. The dissociation of gas-hydrate has probably also induced the instability of the seafloor off SW Taiwan and cuased submarine landslides.

  1. The Influence of SW-GW Exchange on Whole Stream Metabolism Estimates

    Science.gov (United States)

    Seybold, E. C.; McGlynn, B. L.

    2015-12-01

    In recent years, the dynamic connection between SW-GW has been documented across a wide range of aquatic ecosystems. However this appreciation for dynamic GW exchange has not yet been fully incorporated into our interpretation and quantification of stream ecological processes. To address this, we explored the influence of GW exchange on estimates of net ecosystem productivity (NEP) in real time over 4 months in a snowmelt-dominated catchment in Montana. We examine how metabolism varied seasonally, and assess how the relationship between GW exchange and in-stream processes evolved over the snowmelt-baseflow recession. Traditional 1-station metabolism methods do not fully incorporate hydrologic information into NEP estimates. They are generally insensitive to variation in discharge, and do not incorporate travel times or account for GW exchange. Here we demonstrate that failing to account for both gains and losses can bias NEP estimates and fluxes, particularly in systems with high rates of GW exchange. At our site, accounting for GW exchange during high flow conditions when GW-SW exchange was highest increased instantaneous NEP rates by 2.6 times. Over the entire growing season, this led to a 2.4-fold increase in cumulative growing season NEP. Ecosystem metabolism is a biologically mediated process that is often obfuscated by physical hydrological processes. In order to assess the magnitudes of biotic processes, we must first disentangle them from co-occurring physical processes. We demonstrate that SW-GW exchange is an influential physical process that exerts a strong influence on metabolism estimates. We posit that incorporating GW into metabolism methods will influence NEP estimates across a wide range of systems, particularly those with high rates of exchange or strong seasonality in gains and losses. Incorporating hydrology more fully into stream ecological methods is necessary for accurate understanding and quantification of carbon cycling in streams.

  2. Microbial community in the potential gas hydrate area Kaoping Canyon bearing sediment at offshore SW Taiwan

    Science.gov (United States)

    Wu, S. Y.; Hung, C. C.; Lai, S. J.; Ding, J. Y.; Lai, M. C.

    2015-12-01

    The deep sub-seafloor biosphere is among the least-understood habitats on Earth, even though the huge microbial biomass plays a potentially important role in long-term controls of global biogeochemical cycles. The research team from Taiwan, supported by the Central Geological Survey (CGS), has been demonstrated at SW offshore Taiwan that indicated this area is potential gas hydrate region. Therefore, the Gas Hydrate Master Program (GHMP) was brought in the National Energy Program-Phase II (NEP-II) to continue research and development. In this study, the microbial community structure of potential gas hydrate bearing sediments of giant piston core MD-178-10-3291 (KP12N) from the Kaoping Canyon offshore SW of Taiwan were investigated. This core was found many empty spaces and filling huge methane gas (>99.9 %) that might dissociate from solid gas hydrate. 16S rRNA gene clone libraries and phylogenetic analysis showed that the dominant members of Archaea were ANME (13 %), SAGMEG (31 %) and DSAG (20 %), and those of Bacteria were Chloroflexi (13 %), Candidate division JS1 (40 %) and Planctomycetes (15 %). Among them, ANME-3 is only distributed at the sulfate-methane interface (SMI) of 750 cmbsf, and sharing similarity with the Hydrate Ridge clone HydBeg92. ANME-1 and SAGMEG distributed below 750 cmbsf. In addition, DSAG and Candidate division JS1 are most dominant and distributed vertically at all tested depths from 150-3600 cmbsf. Combine the geochemical data and microbial phylotype distribution suggests the potential of gas hydrate bearing sediments at core MD-178-10-3291 (KP12N) from the Kaoping Canyon offshore SW of Taiwan.

  3. Sedimentary features and exploration targets of Middle Permian reservoirs in the SW Sichuan Basin

    Directory of Open Access Journals (Sweden)

    Guoming Xu

    2015-11-01

    Full Text Available The exploration direction and targets for the large-scale Middle Permian gas reservoirs in the Sichuan Basin are hot spots and challenges in current exploration researches. The exploration successes of large gas field of Cambrian Longwangmiao Formation in Gaoshiti-Moxi region, Central Sichuan Basin, indicated that prospective sedimentary facies belt was the basis for the formation of large gas fields. In this paper, based on seismic data, outcrop data and drilling data, the tectonic framework and sedimentary features of the Middle Permian in the SW Sichuan Basin were comprehensively studied. The following conclusions were reached from the perspective of sedimentary facies control: (1 during the Middle Permian, this region was in shallow water gentle slope belts with high energy, where thick reef flat facies were deposited; (2 the basement was uplifted during Middle Permian, resulting in the unconformity weathering crust at the top of Maokou Formation due to erosion; the SW Sichuan Basin was located in the karst slope belt, where epigenic karstification was intense; and (3 reef flat deposits superimposed by karst weathering crust was favorable for the formation of large-scale reef flat karst reservoirs. Based on the combination of the resources conditions and hydrocarbon accumulation conditions in this region, it was pointed out that the Middle Permian has great potential of large-scale reef flat karst gas reservoir due to its advantageous geological conditions; the Middle Permian traps with good hydrocarbon accumulation conditions were developed in the Longmen Mountain front closed structural belt in the SW Sichuan Basin and Western Sichuan Basin depression slope belt, which are favorable targets for large-scale reef flat karst reservoirs.

  4. Curie point depth in the SW Caribbean using the radially averaged spectra of magnetic anomalies

    Science.gov (United States)

    Salazar, Juan M.; Vargas, Carlos A.; Leon, Hermann

    2017-01-01

    We have estimated the Curie Point Depth (CPD) using the average radial power spectrum in a tectonically complex area located in the SW Caribbean basin. Data analyzed came from the World Digital Magnetic Anomaly Map, and three methods have been used to compare results and evaluate uncertainties: Centroid, Spectral Peak, and Forward Modeling. Results show a match along the three methods, suggesting that the CPD values in the area ranging between 6 km and 50 km. The results share the following characteristics: A) High values (> 30 km) are in continental regions; B) There is a trend of maximum CPD values along the SW-NE direction, starting from the Central Cordillera in Colombia to the Maracaibo Lake in Venezuela; C) There is a maximum CPD at the Sierra Nevada de Santa Marta (Colombia) as well as between Costa Rica - Nicaragua and Nicaragua - Honduras borders. The lowest CPD values (coastal regions and offshore. We also tested results by estimating the geothermal gradient and comparing measured observations of the study area. Our results suggest at least five thermal terrains in the SW Caribbean Basin: A) The area that is comprising the Venezuela Basin, the Beata Ridge and the Colombia Basin up to longitude parallel to the Providencia Throat. B) The area that includes zones to the north of the Cocos Ridge and Panam Basin up to the trench. C) The orogenic region of the northern Andes and including areas of the Santa Marta Massif. D) The continental sector that encompasses Nicaragua, northern Costa Rica and eastern of Honduras. E) Corresponds to areas of the northern Venezuela and Colombia, NW of Colombia, the Panamanian territory and the transition zones between the Upper and Lower Nicaragua Rise.

  5. Abnormal number cell division of human thyroid anaplastic carcinoma cell line, SW 1736

    Directory of Open Access Journals (Sweden)

    Keiichi Ikeda

    2015-12-01

    Full Text Available Cell division, during which a mother cell usually divides into two daughter cells during one cell cycle, is the most important physiological event of cell biology. We observed one-to-four cell division during imaging of live SW1736 human thyroid anaplastic carcinoma cells transfected with a plasmid expressing the hybrid protein of green fluorescent protein and histone 2B (plasmid eGFP-H2B. Analysis of the images revealed a mother cell divided into four daughter cells. And one of the abnormally divided daughter cells subsequently formed a dinucleate cell.

  6. Distributed power-law seismicity changes and crustal deformation in the SW Hellenic ARC

    Directory of Open Access Journals (Sweden)

    A. Tzanis

    2003-01-01

    Full Text Available A region of definite accelerating seismic release rates has been identified at the SW Hellenic Arc and Trench system, of Peloponnesus, and to the south-west of the island of Kythera (Greece. The identification was made after detailed, parametric time-to-failure modelling on a 0.1° square grid over the area 20° E – 27° E and 34° N–38° N. The observations are strongly suggestive of terminal-stage critical point behaviour (critical exponent of the order of 0.25, leading to a large earthquake with magnitude 7.1 ± 0.4, to occur at time 2003.6 ± 0.6. In addition to the region of accelerating seismic release rates, an adjacent region of decelerating seismicity was also observed. The acceleration/deceleration pattern appears in such a well structured and organised manner, which is strongly suggestive of a causal relationship. An explanation may be that the observed characteristics of distributed power-law seismicity changes may be produced by stress transfer from a fault, to a region already subjected to stress inhomogeneities, i.e. a region defined by the stress field required to rupture a fault with a specified size, orientation and rake. Around a fault that is going to rupture, there are bright spots (regions of increasing stress and stress shadows (regions relaxing stress; whereas acceleration may be observed in bright spots, deceleration may be expected in the shadows. We concluded that the observed seismic release patterns can possibly be explained with a family of NE-SW oriented, left-lateral, strike-slip to oblique-slip faults, located to the SW of Kythera and Antikythera and capable of producing earthquakes with magnitudes MS ~ 7. Time-to-failure modelling and empirical analysis of earthquakes in the stress bright spots yield a critical exponent of the order 0.25 as expected from theory, and a predicted magnitude and critical time perfectly consistent with the figures given above. Although we have determined an approximate location

  7. Epigallocatechin-3-gallate inhibits proliferation and migration of human colon cancer SW620 cells in vitro

    Institute of Scientific and Technical Information of China (English)

    Fang ZHOU; long ZHOU; Ting WANG; Yuan MU; Biao WU; Dong-lin GUO; Xian-mei ZHANG; Ying WU

    2012-01-01

    Epigallocatechin-3-gallate (EGCG) is the major polyphenolic constituent in green tea.The aim of this study is to investigate the effects of EGCG on proliferation and migration of the human colon cancer SW620 cells.Methods:Proliferation and migration of SW620 cells were induced by the protease-activated receptor 2-agonist peptide (PAR2-AP,100 μmol/L) or factor Vlla (10 nmol/L),and analyzed using MTT and Transwell assays,respectively.The cellular cytoskeleton was stained with rhodamine-conjugated phalloidin and examined with a laser scanning confocal fluorescence microscope.The expression of caspase-7,tissue factor (TF) and matrix metalloproteinase (MMP)-9 in the cells was examined using QT-PCR,ELISA and Western blot assays.The activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and nuclear factor-kappa B (NF-KB) signaling pathways was analyzed with Western blot.Results:Both PAR2-AP and factor Vlla promoted SW620 cell proliferation and migration,and caused cytoskeleton reorganization (increased filopodia and pseudopodia).Pretreatment with EGCG (25,50,75,and 100 μg/mL) dose-dependently blocked the cell proliferation and migration induced by PAR2-AP or factor Vlla.EGCG (100 μg/mL) prevented the cytoskeleton changes induced by PAR2-AP or factor Vlla.EGCG (100 μg/mL) counteracted the down-regulation of caspase-7 expression and up-regulation of TF and MMP-9 expression in the cells treated with PAR2-AP or factor Vlla.Furthermore,it blocked the activation of ERK1/2 and NF-κB (p65/RelA) induced by PAR2-AP or factor Vlla.Conclusion:EGCG blocks the proliferation and migration of SW620 cells induced by PAR2-AP and factor Vlla via inhibition of the ERK1/2 and NF-KB pathways.The compound may serve as a preventive and therapeutic agent for colon cancers.

  8. Kinky thresholds revisited: opportunity costs differ in the NE and SW quadrants.

    Science.gov (United States)

    Eckermann, Simon

    2015-02-01

    Historically, a kinked threshold line on the cost-effectiveness plane at the origin was suggested due to differences in willingness to pay (WTP) for health gain with trade-offs in the north-east (NE) quadrant versus willingness to accept (WTA) cost reductions for health loss with trade-offs in the south-west (SW) quadrant. Empirically, WTA is greater than WTP for equivalent units of health, a finding supported by loss aversion under prospect theory. More recently, appropriate threshold values for health effects have been shown to require an endogenous consideration of the opportunity cost of alternative actions in budget-constrained health systems, but also allocative and displacement inefficiency observed in health system practice. Allocative and displacement inefficiency arise in health systems where the least cost-effective program in contraction has a higher incremental cost-effectiveness ratio (ICER = m) than the most cost-effective program in expansion (ICER = n) and displaced services (ICER = d), respectively. The health shadow price derived by Pekarsky, [Formula: see text] reflects the opportunity cost of best alternative adoption and financing actions in reimbursing new technology with expected incremental costs and net effect allowing for allocative (n < m), and displacement, inefficiency (d < m). This provides an appropriate threshold value for the NE quadrant. In this paper, I show that for trade-offs in the SW quadrant, where new strategies have lower expected net cost while lower expected net effect than current practice, the opportunity cost is contraction of the least cost-effective program, with threshold ICER m. That is, in the SW quadrant, the cost reduction per unit of decreased effect should be compared with the appropriate opportunity cost, best alternative generation of funding. Consequently, appropriate consideration of opportunity cost produces a kink in the threshold at the origin, with the health shadow price in the NE quadrant

  9. SW Sex stars, old novae, and the evolution of cataclysmic variables

    CERN Document Server

    Schmidtobreick, Linda

    2014-01-01

    The population of cataclysmic variables with orbital periods right above the period gap are dominated by systems with extremely high mass transfer rates, the so-called SW Sextantis stars. On the other hand, some old novae in this period range which are expected to show high mass transfer rate instead show photometric and/or spectroscopic resemblance to low mass transfer systems like dwarf novae. We discuss them as candidates for so-called hibernating systems, CVs that changed their mass transfer behaviour due to a previously experienced nova outburst. This paper is designed to provide input for further research and discussion as the results as such are still very preliminary.

  10. Deciphering the brittle evolution of SW Norway through a combined structural, mineralogical and geochronological approach

    Science.gov (United States)

    Scheiber, Thomas; Viola, Giulio; Fredin, Ola; Zwingmann, Horst; Wilkinson, Camilla Maya; Ganerød, Morgan

    2016-04-01

    SW Norway has experienced a complex brittle history after cessation of the Caledonian orogeny, and the recent discoveries of major hydrocarbon reserves in heavily fractured and weathered basement offshore SW Norway has triggered a renewed interest in understanding this complex tectonic evolution. In this contribution we present results from a multidisciplinary study combining lineament analysis, field work, paleo-stress inversion, mineralogical characterization and radiometric dating in the Bømlo area of SW Norway in order to develop a tectonic model for the brittle evolution of this important region. The study area mainly consists of the Rolvsnes granodiorite (U-Pb zircon age of ca. 466 Ma), which is devoid of penetrative ductile deformation features. The first identified brittle faults are muscovite-bearing top-to-the-NNW thrusts and E-W striking dextral strike-slip faults decorated with stretched biotite. These are mechanically compatible and are assigned to the same NNW-SSE transpressional regime. Ar-Ar muscovite and biotite dates of ca. 450 Ma (Late Ordovician) indicate fault activity in the course of a Taconian-equivalent orogenic event. During the subsequent Silurian Laurentia-Baltica collision variably oriented, lower-grade chlorite and epidote-coated faults formed in response to a ENE-WSW compressional stress regime. A large number of mainly N-S striking normal faults consist of variably thick fault gouge cores with illite, quartz, kaolinite, calcite and epidote mineralizations, accommodating mainly E-W extension. K-Ar dating of illites separated from representative fault gouges and zones of altered granodiorite constrain deformation ranging from the Permian to the Late Jurassic, indicating a long history of crustal extension where faults were repeatedly activated. In addition, a set of ca. SW-NE striking faults associated with alteration zones give Cretaceous dates, either representing a young phase of NW-SE extension or reactivation of previously formed

  11. Strangelet search in S-W collisions at 200 A.GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Appelquist, G.; Baglin, C.; Bohm, C.; Borer, K.; Bussiere, A.; Elsener, K.; Dittus, F.; Frei, D.; Guillaud, J.P.; Hovander, B.; Klingenberg, R.; Lohmann, K.D.; Hugentobler, E.; Moser, U.; Pretzl, K.; Schacher, J.; Sellden, B.; Stoffel, F.; Volken, W.; Zhang, Q.P. [Bern Univ. (Switzerland)]|[CERN, Geneva (Switzerland)]|[LAPP, CNRS-IN2P3, Annecy-le-Vieux (France)]|[Stockholm Univ. (Sweden)

    1994-01-03

    We have searched for new massive particles with a low charge to mass ratio in S-W collisions at a beam momentum of 200 GeV/c per nucleon. Upper limits for the production of strangelets with a mass to charge ratio up to 60 GeV/c{sup 2} at rigidities of {+-}150 GV are reported. This study was done with a test setup using as a spectrometer the H{sub 6}-beamline in the north area at CERN. (orig.)

  12. Disk-Anchored Magnetic Propellers - A Cure for the SW Sex Syndrome

    OpenAIRE

    Horne, Keith

    1999-01-01

    In AE Aqr, magnetic fields transfer energy and angular momentum from a rapidly spinning white dwarf to material in the gas stream from the companion star, with the effect of spinning down the white dwarf while flinging the gas stream material out of the binary system. This magnetic propeller produces a host of observable signatures, chief among which are broad single-peaked flaring emission lines with phase-shifted orbital kinematics. SW Sex stars have accretion disks, but also broad single-p...

  13. Chronic Hypertension Leads to Neurodegeneration in the TgSwDI Mouse Model of Alzheimer's Disease.

    Science.gov (United States)

    Kruyer, Anna; Soplop, Nadine; Strickland, Sidney; Norris, Erin H

    2015-07-01

    Numerous epidemiological studies link vascular disorders, such as hypertension, diabetes mellitus, and stroke, with Alzheimer's disease (AD). Hypertension, specifically, is an important modifiable risk factor for late-onset AD. To examine the link between midlife hypertension and the onset of AD later in life, we chemically induced chronic hypertension in the TgSwDI mouse model of AD in early adulthood. Hypertension accelerated cognitive deficits in the Barnes maze test (Phypertension induced hippocampal neurodegeneration at an early age in this mouse line (43% reduction in the dorsal subiculum; P<0.05), establishing this as a useful research model of AD with mixed vascular and amyloid pathologies.

  14. The formation of lipid droplets favors intracellular Mycobacterium leprae survival in SW-10, non-myelinating Schwann cells

    Science.gov (United States)

    Jin, Song-Hyo; An, Sung-Kwan

    2017-01-01

    Leprosy is a chronic infectious disease that is caused by the obligate intracellular pathogen Mycobacterium leprae (M.leprae), which is the leading cause of all non-traumatic peripheral neuropathies worldwide. Although both myelinating and non-myelinating Schwann cells are infected by M.leprae in patients with lepromatous leprosy, M.leprae preferentially invades the non-myelinating Schwann cells. However, the effect of M.leprae infection on non-myelinating Schwann cells has not been elucidated. Lipid droplets (LDs) are found in M.leprae-infected Schwann cells in the nerve biopsies of lepromatous leprosy patients. M.leprae-induced LD formation favors intracellular M.leprae survival in primary Schwann cells and in a myelinating Schwann cell line referred to as ST88-14. In the current study, we initially characterized SW-10 cells and investigated the effects of LDs on M.leprae-infected SW-10 cells, which are non-myelinating Schwann cells. SW-10 cells express S100, a marker for cells from the neural crest, and NGFR p75, a marker for immature or non-myelinating Schwann cells. SW-10 cells, however, do not express myelin basic protein (MBP), a marker for myelinating Schwann cells, and myelin protein zero (MPZ), a marker for precursor, immature, or myelinating Schwann cells, all of which suggests that SW-10 cells are non-myelinating Schwann cells. In addition, SW-10 cells have phagocytic activity and can be infected with M. leprae. Infection with M. leprae induces the formation of LDs. Furthermore, inhibiting the formation of M. leprae-induced LD enhances the maturation of phagosomes containing live M.leprae and decreases the ATP content in the M. leprae found in SW-10 cells. These facts suggest that LD formation by M. leprae favors intracellular M. leprae survival in SW-10 cells, which leads to the logical conclusion that M.leprae-infected SW-10 cells can be a new model for investigating the interaction of M.leprae with non-myelinating Schwann cells. PMID:28636650

  15. Identification of the Novel TMEM16A Inhibitor Dehydroandrographolide and Its Anticancer Activity on SW620 Cells.

    Directory of Open Access Journals (Sweden)

    Yujie Sui

    Full Text Available TMEM16A, a calcium-activated chloride channel (CaCC, is highly amplified and expressed in human cancers and is involved in the growth and metastasis of some malignancies. Inhibition of TMEM16A represents a novel pharmaceutical approach for the treatment of cancers and metastases. The purpose of this study is to identify a new TMEM16A inhibitor, investigate the effects of this inhibitor on the proliferation and metastasis of TMEM16A-amplified SW620 cells, and to elucidate the underlying molecular mechanism in vitro. We identified a novel small-molecule TMEM16A inhibitor dehydroandrographolide (DP. By using patch clamp electrophysiology, we showed that DP inhibited TMEM16A chloride currents in Fisher rat thyroid (FRT cells that were transfected stably with human TMEM16A and in TMEM16A-overexpressed SW620 cells but did not alter cystic fibrosis transmembrane conductance regulator (CFTR chloride currents. Further functional studies showed that DP suppressed the proliferation of SW620 cells in a dose- and time-dependent manner using MTT assays. Moreover, DP significantly inhibited migration and invasion of SW620 cells as detected by wound-healing and transwell assays. Further mechanistic study demonstrated that knockdown of human TMEM16A decreased the inhibitory effect of DP on the proliferation of SW620 cells and that TMEM16A-dependent cells (SW620 and HCT116 were more sensitive to DP than TMEM16A-independent cells (SW480 and HCT8. In addition, we found that treatment of SW620 cells with DP led to a decrease in TMEM16A protein levels but had no effect on TMEM16A mRNA levels. The current work reveals that DP, a novel TMEM16A inhibitor, exerts its anticancer activity on SW620 cells partly through a TMEM16A-dependent mechanism, which may introduce a new targeting approach for an antitumour therapy in TMEM16A-amplified cancers.

  16. Effect of an interactive cardiopulmonary resuscitation assist device with an automated external defibrillator synchronised with a ventilator on the CPR performance of emergency medical service staff: a randomised simulation study.

    Science.gov (United States)

    Nitzschke, Rainer; Doehn, Christoph; Kersten, Jan F; Blanz, Julian; Kalwa, Tobias J; Scotti, Norman A; Kubitz, Jens C

    2017-04-04

    The present study evaluates whether the quality of advanced cardiac life support (ALS) is improved with an interactive prototype assist device. This device consists of an automated external defibrillator linked to a ventilator and provides synchronised visual and acoustic instructions for guidance through the ALS algorithm and assistance for face-mask ventilations. We compared the cardiopulmonary resuscitation (CPR) quality of emergency medical system (EMS) staff members using the study device or standard equipment in a mannequin simulation study with a prospective, controlled, randomised cross-over study design. Main outcome was the effect of the study device compared to the standard equipment and the effect of the number of prior ALS trainings of the EMS staff on the CPR quality. Data were analysed using analyses of covariance (ANCOVA) and binary logistic regression, accounting for the study design. In 106 simulations of 56 two-person rescuer teams, the mean hands-off time was 24.5% with study equipment and 23.5% with standard equipment (Difference 1.0% (95% CI: -0.4 to 2.5%); p = 0.156). With both types of equipment, the hands-off time decreased with an increasing cumulative number of previous CPR trainings (p = 0.042). The study equipment reduced the mean time until administration of adrenaline (epinephrine) by 23 s (p = 0.003) and that of amiodarone by 17 s (p = 0.016). It also increased the mean number of changes in the person doing chest compressions (0.6 per simulation; p trainings, the time intervals in the ALS algorithm until the defibrillations decreased with standard equipment but increased with the study device. EMS staff with limited training in CPR profit from guidance through the ALS algorithm by the study device. However, the study device somehow reduced the ALS quality of well-trained rescuers and thus can only be recommended for ALS provider with limited experience.

  17. Disentangling the excitation conditions of the dense gas in M17 SW

    CERN Document Server

    Pérez-Beaupuits, J P; Spaans, M; Ossenkopf, V; Menten, K M; Requena-Torres, M A; Wiesemeyer, H; Stutzki, J; Guevara, C; Simon, R

    2015-01-01

    We probe the chemical and energetic conditions in dense gas created by radiative feedback through observations of multiple CO, HCN and HCO$^+$ transitions toward the dense core of M17 SW. We used the dual band receiver GREAT on board the SOFIA airborne telescope to obtain maps of the $J=16-15$, $J=12-11$, and $J=11-10$ transitions of $^{12}$CO. We compare these maps with corresponding APEX and IRAM 30m telescope data for low- and mid-$J$ CO, HCN and HCO$^+$ emission lines, including maps of the HCN $J=8-7$ and HCO$^+$ $J=9-8$ transitions. The excitation conditions of $^{12}$CO, HCO$^+$ and HCN are estimated with a two-phase non-LTE radiative transfer model of the line spectral energy distributions (LSEDs) at four selected positions. The energy balance at these positions is also studied. We obtained extensive LSEDs for the CO, HCN and HCO$^+$ molecules toward M17 SW. The LSED shape, particularly the high-$J$ tail of the CO lines observed with SOFIA/GREAT, is distinctive for the underlying excitation conditions...

  18. Transpressive suture and flower structure: the Tomar-Badajoz-Cordoba shear zone, SW Iberia

    Science.gov (United States)

    Marti Linares, D.; Palomeras, I.; Perez-Estaun, A.; Carbonell, R.; Simancas, F.; Ayarza, P.; Tejero, R.; Martín-Parra, L.; Matas, J.; Lodeiro, F.; Mansilla, L.

    2009-12-01

    The Tomar-Badajoz-Córdoba shear Zone (TBCSZ) is a major structural element located in SW-Iberia. This is considered a suture that separates the Central Iberian Zone (CIZ) in NE and Ossa Morena Zone (OMZ) in SW. It is at least 380km in length and 10 to 20km width. It is a left lateral transpressive flower structure. The strike-slip displacement decays from SE to NW. Its axial zone includes a high grade metamorphic rock unit known as the Central Unit (CU) containing eclogites, and also suture lithotypes as ophiolites. It has been interpreted as a Variscan suture or a reworked Cadomian suture in intraplate regime during the Variscan cycle. This important structure has been imaged by 2 deep seismic reflection transects, the IBERSEIS in 2003 and more recently by ALCUDIA. The good quality of the seismic data sets constrains the internal architecture of this transpressional zone imaging a crustal scale flower structure. The structure features a north dipping wedge limited by two bands of reflectors that reach the middle crust (5 s). Beneath that and slightly to the north a wedge of relatively high amplitude reflectivity dips to the south into the mantle for 10-15 km. This structure is most probably the seismic signature of a complex structure result of deformation associated to a strike slip fault.

  19. An Orbital Stability Study of the Proposed Companions of SW Lyncis

    CERN Document Server

    Hinse, Tobias C; Wittenmyer, Robert A

    2014-01-01

    We have investigated the dynamical stability of the proposed companions orbiting the Algol type short-period eclipsing binary SW Lyncis (Kim et al. 2010). The two candidate companions are of stellar to sub-stellar nature, and were inferred from timing measurements of the system's primary and secondary eclipses. We applied well-tested numerical techniques to accurately integrate the orbits of the two companions and to test for chaotic dynamical behaviour. We carried out the stability analysis within a systematic parameter survey varying both the geometries and orientation of the orbits of the companions, as well as their masses. In all our numerical integrations we found that the proposed SW Lyn multi-body system is highly unstable on time-scales on the order of 1000 years. Our results cast doubt on the interpretation that the timing variations are caused by two companions. This work demonstrates that a straightforward dynamical analysis can help to test whether a best-fit companion-based model is a physically...

  20. Benchmarking of the SW80 polycrystalline silicon modules using the sun as source of light

    Directory of Open Access Journals (Sweden)

    Mtunzi Busiso

    2014-01-01

    Full Text Available Benchmarking of modules is necessary as it helps to note any changes on the operation of the modules when in operation outdoors. The equipment needed to do this has been found to be very expensive hence the need of cheaper methods. This paper tries to show how this can be achieved using outdoor conditions and an I/V measuring instrument PVPM1000. SW80 photovoltaic modules were tested using outdoor conditions. The current and voltage measurements were taken at solar noon and converted to the standard test conditions (STC, 1000 Wm-2 AM 1.5 and 25°C. These normalized values were in turn taken as bench mark values of the modules. Future measurements can then be taken at solar noon and compared to benchmark values; any variations in performance can then be noted. The variations on benchmark values as compared to the manufacturer STC values for SW80 type module were noted. The measurements were carried out under typical South Africa meteorological conditions.

  1. Photometry of the SW Sex-type nova-like BH Lyncis in high state

    CERN Document Server

    Stanishev, V; Genkov, V

    2006-01-01

    Aims: We present a photometric study of the deeply eclipsing SW Sex-type nova-like cataclysmic variable star BH Lyn Methods: Time-resolved V-band CCD photometry was obtained for seven nights between 1999 and 2004. Results: We determined 11 new eclipse timings of BH Lyn and derived a refined orbital ephemeris with an orbital period of 0.155875577(14) day. During the observations, BH Lyn was in high-state with V~15.5 mag. The star presents ~1.5 mag deep eclipses with mean full-width at half-flux of 0.0683(+/-0.0054)P_orb. The eclipse shape is highly variable, even changing form cycle to cycle. This is most likely due to accretion disc surface brightness distribution variations, most probably caused by strong flickering. Time-dependent accretion disc self-occultation or variations of the hot spot(s) intensity are also possible explanations. Negative superhumps with period of ~0.145 day are detected in two long runs in 2000. A possible connection between SW Sex and negative superhump phenomena through the presenc...

  2. Disk-Anchored Magnetic Propellers A Cure for the SW Sex Syndrome

    CERN Document Server

    Horne, K

    1999-01-01

    In AE Aqr, magnetic fields transfer energy and angular momentum from a rapidly spinning white dwarf to material in the gas stream from the companion star, with the effect of spinning down the white dwarf while flinging the gas stream material out of the binary system. This magnetic propeller produces a host of observable signatures, chief among which are broad single-peaked flaring emission lines with phase-shifted orbital kinematics. SW Sex stars have accretion disks, but also broad single-peaked phase-shifted emission lines similar to those seen in AE Aqr. We propose that a magnetic propeller similar to that which operates in AE Aqr is also at work in SW Sex stars -- and to some extent in all nova-like systems. The propeller is anchored in the inner accretion disk, rather than or in addition to the white dwarf. Energy and angular momentum are thereby extracted from the inner disk and transferred to gas stream material flowing above the disk, which is consequently pitched out of the system. This provides a n...

  3. Effects of phycoerythrin from Gracilaria lemaneiformis in proliferation and apoptosis of SW480 cells.

    Science.gov (United States)

    Li, Peizhen; Ying, Jun; Chang, Qingli; Zhu, Wen; Yang, Guangjian; Xu, Teng; Yi, Huiguang; Pan, Ruowang; Zhang, Enyong; Zeng, Xiaofeng; Yan, Chunxia; Bao, Qiyu; Li, Shengbin

    2016-12-01

    We studied phycoerythrin (PE) in human SW480 tumor cells and the underlying molecular mechanisms of action. PE inhibited cell proliferation as evidenced by CCK-8 assay. The IC50 values of phycoerythrin were 48.2 and 27.4 µg/ml for 24 and 48 h of exposure, respectively. PE induced apoptosis and cell cycle arrest in SW480 cells as observed under electron microscopy and with flow cytometry. Apoptosis increased from 5.1 (controls) to 39.0% in 80.0 µg/ml PE-treated cells. Differences in protein expression were identified using proteomic techniques. Protein spots (1018±60 and 1010±60) were resolved in PE-treated and untreated group. Forty differential protein spots were analyzed with MALDI-TOF-MS, including GRP78 and NPM1. The expression as measured by qPCR and western blotting agreed with data from two-dimensional electrophoresis. GRP78, NPM1, MTHSP75, Ezrin and Annexin A2 were decreased and HSP60 was increased after PE treatment, indicating that PE may target multiple proteins to induce apoptosis.

  4. Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages

    Directory of Open Access Journals (Sweden)

    Liwei Dong

    2015-06-01

    Full Text Available Echinacoside is a natural compound with potent reactive oxygen species (ROS-scavenging and anti-oxidative bioactivities, which protect cells from oxidative damages. As cancer cells are often under intense oxidative stress, we therefore tested if Echinacoside treatment would promote cancer development. Surprisingly, we found that Echinacoside significantly inhibited the growth and proliferation of a panel of cancer cell lines. Treatment of the human SW480 cancer cells with Echinacoside resulted in marked apoptosis and cell cycle arrest, together with a significant increase in active caspase 3 and cleaved PARP, and upregulation of the G1/S-CDK blocker CDKN1B (p21. Interestingly, immunocytochemistry examination of drug-treated cancer cells revealed that Echinacoside caused a significant increase of intracellular oxidized guanine, 8-oxoG, and dramatic upregulation of the double-strand DNA break (DSB-binding protein 53BP1, suggesting that Echinacoside induced cell cycle arrest and apoptosis in SW480 cancer cells via induction of oxidative DNA damages. These results establish Echinacoside as a novel chemical scaffold for development of anticancer drugs.

  5. rSW-seq: Algorithm for detection of copy number alterations in deep sequencing data

    Directory of Open Access Journals (Sweden)

    Kim Tae-Min

    2010-08-01

    Full Text Available Abstract Background Recent advances in sequencing technologies have enabled generation of large-scale genome sequencing data. These data can be used to characterize a variety of genomic features, including the DNA copy number profile of a cancer genome. A robust and reliable method for screening chromosomal alterations would allow a detailed characterization of the cancer genome with unprecedented accuracy. Results We develop a method for identification of copy number alterations in a tumor genome compared to its matched control, based on application of Smith-Waterman algorithm to single-end sequencing data. In a performance test with simulated data, our algorithm shows >90% sensitivity and >90% precision in detecting a single copy number change that contains approximately 500 reads for the normal sample. With 100-bp reads, this corresponds to a ~50 kb region for 1X genome coverage of the human genome. We further refine the algorithm to develop rSW-seq, (recursive Smith-Waterman-seq to identify alterations in a complex configuration, which are commonly observed in the human cancer genome. To validate our approach, we compare our algorithm with an existing algorithm using simulated and publicly available datasets. We also compare the sequencing-based profiles to microarray-based results. Conclusion We propose rSW-seq as an efficient method for detecting copy number changes in the tumor genome.

  6. Extended [C I] and ^{13}CO(5-4) Emission in M17SW

    CERN Document Server

    Howe, J E; Bergin, E A; Chin, G; Erickson, N R; Goldsmith, P F; Harwit, M; Hollenbach, D J; Kaufman, M J; Kleiner, S C; Koch, D G; Neufeld, D A; Patten, B M; Plume, R; Schieder, R; Snell, R L; Stauffer, J R; Tolls, V; Wang, Z; Winnewisser, G; Zhang, Y F; Melnick, G J

    2000-01-01

    We mapped a 13 by 22 pc region in emission from 492 GHz [C I] and, for the first time, 551 GHz ^{13}CO(5-4) in the giant molecular cloud M17SW, using the Submillimeter Wave Astronomy Satellite. The morphologies of the [C I] and ^{13}CO emission are strikingly similar. The extent and intensity of the [C I] and ^{13}CO(5-4) emission is explained as arising from photodissociation regions on the surfaces of embedded molecular clumps. Modeling of the ^{13}CO(5-4) emission in comparison to ^{13}CO(1-0) indicates a temperature gradient across the cloud, peaking to at least 63 K near the M17 ionization front and decreasing to at least 20 K at the western edge of the cloud. We see no correlation between gas density and column density. The beam-averaged column density of C I in the core is 1x10^{18} cm^-2, and the mean column density ratio N(C I)/N(CO) is about 0.4. The variations of N(C I)/N(CO) with position in M17SW indicate a similar clump size distribution throughout the cloud.

  7. Crustal structure of the SW Iberian passive margin: The westernmost remnant of the Ligurian Tethys?

    Science.gov (United States)

    Ramos, A.; Fernández, O.; Torne, M.; Sánchez de la Muela, A.; Muñoz, J. A.; Terrinha, P.; Manatschal, G.; Salas, M. C.

    2017-05-01

    At present, the SW Iberian margin is located along the convergent Iberia-Nubia plate boundary. In Mesozoic times, the margin was located at the triple junction of the Ligurian Tethys, Central Atlantic and Northern Atlantic. The characterization of its crustal structure has allowed us to propose a configuration for this triple junction and to determine the role that this transform margin played within the plate kinematic system. In this paper we present an integrated study based on the interpretation of a 2D regional multichannel seismic survey consisting of 58 profiles, tied with onshore geology and exploratory wells, and on gravimetric modeling performed over four NW-SE trending profiles. Integrated interpretation of MCS data combined with 2D gravity modeling reveals a complex pattern in the southward crustal thinning of SW Iberia and supports the possible presence of oceanic crust under the Gulf of Cadiz. The tapering of Iberian crust is characterized by steps with rapid changes in the thickness of the crust, and thinning to Bank. Margin inversion and the pre-existing extensional crustal structure are responsible for the areal distribution and amplitude of the prominent positive gravity anomaly observed in the Gulf of Cadiz.

  8. Regional forecast model for the Olea pollen season in Extremadura (SW Spain)

    Science.gov (United States)

    Fernández-Rodríguez, Santiago; Durán-Barroso, Pablo; Silva-Palacios, Inmaculada; Tormo-Molina, Rafael; Maya-Manzano, José María; Gonzalo-Garijo, Ángela

    2016-10-01

    The olive tree ( Olea europaea) is a predominantly Mediterranean anemophilous species. The pollen allergens from this tree are an important cause of allergic problems. Olea pollen may be relevant in relation to climate change, due to the fact that its flowering phenology is related to meteorological parameters. This study aims to investigate airborne Olea pollen data from a city on the SW Iberian Peninsula, to analyse the trends in these data and their relationships with meteorological parameters using time series analysis. Aerobiological sampling was conducted from 1994 to 2013 in Badajoz (SW Spain) using a 7-day Hirst-type volumetric sampler. The main Olea pollen season lasted an average of 34 days, from May 4th to June 7th. The model proposed to forecast airborne pollen concentrations, described by one equation. This expression is composed of two terms: the first term represents the resilience of the pollen concentration trend in the air according to the average concentration of the previous 10 days; the second term was obtained from considering the actual pollen concentration value, which is calculated based on the most representative meteorological variables multiplied by a fitting coefficient. Due to the allergenic characteristics of this pollen type, it should be necessary to forecast its short-term prevalence using a long record of data in a city with a Mediterranean climate. The model obtained provides a suitable level of confidence to forecast Olea airborne pollen concentration.

  9. The Shortwave (SW) Clear-Sky Detection and Fitting Algorithm: Algorithm Operational Details and Explanations

    Energy Technology Data Exchange (ETDEWEB)

    Long, CN; Gaustad, KL

    2004-01-31

    This document describes some specifics of the algorithm for detecting clear skies and fitting clear-sky shortwave (SW) functions described in Long and Ackerman (2000). This algorithm forms the basis of the ARM SW FLUX ANAL 1Long VAP. In the Atmospheric Radiation Measurement (ARM) case, the value added procedures (VAP) can be described as having three parts: a “front end,” a “black box,” and a “back end.” The “front end” handles the file management of the processing, what range of data files to process in the run, which configuration file to use for each site, extracting the data from the ARM NetCDF files into an ASCII format for the code to process, etc. The “back end” produces ARM-format NetCDF files of the output and other file management. The “black box” is the processing code(s), and is what is discussed in this document. Details on the “front” and “back” ends of the ARM VAP are presented elsewhere.

  10. Inhibition of Proto-oncogene Pokemon Expression by siRNA Expression Vector in SW480 Cells%siRNA表达载体对SW480细胞原癌基因Pokemon的抑制

    Institute of Scientific and Technical Information of China (English)

    郭睿; 李喜霞; 解军

    2009-01-01

    观察siRNA表达载体对SW480细胞中Pokemon原癌基因的抑制效应,为进一步研究该基因的功能奠定基础.构建针对Pokemon基因的RNAi质粒表达载体,脂质体法转染人结直肠癌SW480细胞系,观察转染效率及细胞表型变化.稳定转染后,实时荧光定量PCR和Western blot检测SW480细胞中Pokemon mRNA及蛋白质的表达情况;MTT法检测siRNA对SW480细胞恶性增殖的影响;流式细胞仪分析细胞凋亡改变.镜下观察阳性转染率约36%,转染表达载体后细胞形态发生了显著变化;Pokemon mRNA及蛋白质的表达受到明显抑制:与阴性对照组相比,表达质粒产生的siRNA对Pokemon mRNA的抑制率在转染后24 h和48 h分别为34.2%和67.7%;对蛋白的抑制率在48 h和72 h分别为48.3%和73.6%.MTT法检测细胞生长曲线表明Pokemon抑制可使SW480细胞生长速度明显减慢;流式细胞仪分析显示转染Pokemon siRNA表达质粒后SW480细胞凋亡增加.构建的RNAi表达载体可以有效抑制SW480细胞中Pokemon基因的表达,并对SW480细胞的生长具有明显抑制及诱导凋亡作用.

  11. Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480 and Epithelial Cervical Carcinoma (C33-A

    Directory of Open Access Journals (Sweden)

    Mirandeli Bautista

    2011-03-01

    Full Text Available Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent  effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480; By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines.

  12. 三角旗舰产品麦哲伦SW2系列音箱

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    法国三角音箱的旗舰Magellan(麦哲伦)系列音箱面市几年来,广受业界及市场好评,经过厂方的不断努力和深入研发,最近厂方推出了全新的旗舰Magellan SW2系列音箱,该系列包含Grand Concert SW2(大演奏会)、ConcertoSW2(协奏曲)、Quatuor(四重奏)、Cello(大提琴)、Duetto(二重奏)共5款产品。

  13. Geodynamic evolution of the SW Variscides: Orogenic collapse shown by new tectonometamorphic and isotopic data from western Ossa-Morena Zone, SW Iberia

    Science.gov (United States)

    Rosas, F. M.; Marques, F. O.; BallèVre, M.; Tassinari, C.

    2008-12-01

    The pre-Mesozoic geodynamic evolution of SW Iberia has been investigated on the basis of detailed structural analysis, isotope dating, and petrologic study of high-pressure (HP) rocks, revealing the superposition of several tectonometamorphic events: (1) An HP event older than circa 358 Ma is recorded in basic rocks preserved inside marbles, which suggests subduction of a continental margin. The deformation associated with this stage is recorded by a refractory graphite fabric and noncoaxial mesoscopic structures found within the host metasediments. The sense of shear is top to south, revealing thrusting synthetic with subduction (underthrusting) to the north. (2) Recrystallization before circa 358 Ma is due to a regional-scale thermal episode and magmatism. (3) Noncoaxial deformation with top to north sense of shear in northward dipping large-scale shear zones is associated with pervasive hydration and metamorphic retrogression under mostly greenschist facies. This indicates exhumation by normal faulting in a detachment zone confined to the top to north and north dipping shear zones during postorogenic collapse soon after 358 Ma ago (inversion of earlier top to south thrusts). (4) Static recrystallization at circa 318 Ma is due to regional-scale granitic intrusions.

  14. Perturbative determination of c{sub sw} for plaquette and Symanzik gauge action and stout link clover fermions

    Energy Technology Data Exchange (ETDEWEB)

    Horsley, R. [Edinburgh Univ. (United Kingdom). School of Physics; Perlt, H.; Schiller, A. [Leipzig Univ. (Germany). Inst. fuer Theoretische Physik; Rakow, P.E.L. [Liverpool Univ. (United Kingdom). Theoretical Physics Division, Dept. of Mathematical Sicences; Schierholz, G. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2008-06-15

    Using plaquette and Symanzik improved gauge action and stout link clover fermions we determine the improvement coefficient c{sub SW} in one-loop lattice perturbation theory from the off-shell quark-quark-gluon three-point function. In addition, we compute the coefficients needed for the most general form of quark field improvement and present the one-loop result for the critical hopping parameter {kappa}{sub c}. We discuss mean field improvement for c{sub SW} and {kappa}{sub c} and the choice of the mean field coupling for the actions we have considered. (orig.)

  15. The $SW(3/2,2)$ superconformal algebra via a Quantum Hamiltonian Reduction of $osp(3|2)$

    CERN Document Server

    Díaz, Lázaro O Rodríguez

    2016-01-01

    We prove that the family of non-linear $W$-algebras $SW(3/2,2)$ which are extensions of the $N=1$ superconformal algebra by a primary supercurrent of conformal weight $2$ can be realized as a quantum Hamiltonian reduction of the Lie superalgebra $osp(3|2)$. In consequence we obtain an explicit free field realization of the algebra in terms of the screening operators. At central charge $c=12$ the $SW(3/2,2)$ superconformal algebra corresponds to the superconformal algebra associated to sigma models based on eight-dimensional manifolds with special holonomy $Spin(7)$, i.e., the Shatashvili-Vafa $Spin(7)$ superconformal algebra.

  16. Cardiopulmonary Resuscitation (CPR): First Aid

    Science.gov (United States)

    ... while you attend to the baby. Compressions: Restore blood circulation Place the baby on his or her back on a firm, flat surface, such as a table. The floor or ground also will do. Imagine a horizontal ...

  17. Development of pneumoperitoneum after CPR

    OpenAIRE

    Mani, Vishnu R.; Pradhan, Laxman; Gray, Sanjiv

    2014-01-01

    INTRODUCTION Chest compressions are performed routinely and have several well-known complications, however one of the rare complications is pneumoperitoneum caused by air entry through a perforation of the viscus. The exact cause of the perforation is not always clear. Furthermore, this rarely reported condition does not have clear management guidelines. PRESENTATION OF CASE We present an uncommon complication of pneumoperitoneum following successful resuscitation possibly caused by the prese...

  18. Development of pneumoperitoneum after CPR

    Science.gov (United States)

    Mani, Vishnu R.; Pradhan, Laxman; Gray, Sanjiv

    2014-01-01

    INTRODUCTION Chest compressions are performed routinely and have several well-known complications, however one of the rare complications is pneumoperitoneum caused by air entry through a perforation of the viscus. The exact cause of the perforation is not always clear. Furthermore, this rarely reported condition does not have clear management guidelines. PRESENTATION OF CASE We present an uncommon complication of pneumoperitoneum following successful resuscitation possibly caused by the presence of an orogastric tube at the time of compressions in a 79 year old Hispanic male. Following chest compressions, a distended and tympanic abdomen was noted and air seen under the diaphragm in X-ray imaging. DISCUSSION A review of previous case reports along with etiology and evaluation of risk factors is presented. CONCLUSION Although the exact cause of pneumoperitoneum cannot be confirmed, emergency personnel should be aware of the risk factors associated with viscus perforation during chest compressions. PMID:25506850

  19. 3D 动漫心肺复苏教育游戏的设计与实现%Design and realization of CPR educational games with 3D animation

    Institute of Scientific and Technical Information of China (English)

    周静; 江智霞; 楼婷; 胡汝均; 李玉

    2016-01-01

    As a hotspot in research on the development of information society,educational games are gradually promoting the reform of higher education.Taking the case of cardiopulmonary resuscitation (CPR)games for example,the paper introduces the design ideas,elements and structure of CPR educational games with 3D animation in order to provide some helpful advice for researchers of medical educational games.%教育游戏作为信息社会发展研究的一个热点,逐步推动了高等教育的改革。文章以心肺复苏为游戏案例,介绍了3D 动漫心肺复苏教育游戏设计的思路以及元素设计和构建,以期对医学教育游戏研究者有所借鉴与助益。

  20. 影响东莞市120院前心肺复苏成功相关因素研究%Related Factors Research of 120 Prehospital Cardiopulmonary Resuscitation(CPR) Success in Dongguan

    Institute of Scientific and Technical Information of China (English)

    曹建国; 刘同刚; 黄清丽; 李海燕; 张慧锋; 刘伟权

    2014-01-01

    目的:了解东莞市120院前心肺复苏现状和影响因素。方法:做过心肺复苏152例患者填写调查表,用Epidata建立数据库,用SPSS 13.0统计学软件进行统计学分析。结果:心肺复苏术前呼吸心搏停止时间,院前和急诊科患者分别为(20.32±18.21)min和(16.92±5.13)min(P<0.05)。院前采用不同人工通气复苏效果比较差异有统计学意义(P<0.05),面罩辅助呼吸给氧优于气管插管,而在急诊科则反之。复苏术前不同心电图比较差异有统计学意义(P<0.01),以心室颤动最佳,心电静止最差。院前和急诊科生存率分别为9.76%和17.14%(P<0.01)。结论:东莞市院前120和急诊科心肺复苏比较,复苏开始的时间,通气的方法,复苏前心电图的类形和结果差异有统计学意义。%Objective:To study the statusquo and influencing factors of 120 prehospital cardiopulmonary resuscitation(CPR) in Dongguan. Method:152 cases who did CPR completed the questionnaire,establish a database with Epidata,were statistically analyzed using SPSS 13.0 statistical software. Result:Breathing and cardiac arrest time before CPR of prehospital first-aid patients and emergency department first-aid patients were (20.32±18.21)min and (16.92±20.13)min(P<0.05).The recovery effects of patients with different artificial ventilation prehospital were statistically significant(P<0.05),mask assisted respiration to oxygen was better than endotracheal intubation assisted respiration to oxygen,and that in the emergency department was opposite.The difference of different ECG before resuscitation was statistically significant(P<0.01),the best was ventricular fibrillation,the worst was ventricular still.The survival rates of prehospital and emergency department were 9.76% and 17.14%(P<0.01).Conclusion:The differences of recovery begins time,ventilation methods,ECG classes before recovery and outcome between 120 prehospital CPR and emergency department CPR in

  1. 面向国产CPU SW-1600的向量重组%DOMESTIC PRODUCED CPU SW-1600 ORIENTED VECTOR REGROUP

    Institute of Scientific and Technical Information of China (English)

    魏帅; 赵荣彩; 姚远

    2011-01-01

    Since vectorized regroup instructions sire comparatively complex whereas different instructions correspond to different delays, it is hard to find out a uniform and efficient vector regroup algorithm. The paper analyzes shifting and insertion/extraction instructions that are offered by domestic produced CPU SW-1600, and presents an optimal algorithm that only depends on shifting or insertion/extraction instructions to realize vector regroup as well as an efficient algorithm that integrates the two types of instructions to realize vector regroup. At last it is proven by experiments that the algorithms can better vectorize programs. The speedup ratio for integer type values reaches 7.31 while that for complex double precision float type programs reaches 1. 83.%由于向量化重组指令比较复杂并且不同指令有不同的延迟,从而难以寻找一种统一高效的向量重组算法.对国产CPUSW-1600提供的移位和插入提取指令进行了分析,提出单独依靠移位或插入提取指令实现向量重组的最优算法,并综合这两类指令实现向量重组的高效算法.最后通过实验证明该算法可以较好地对程序进行向量化,对整型数据的加速比达到7.31,对复杂的双精度浮点型程序的加速比也达到1.83.

  2. Nuclear DNA content of the pigeon orchid (Dendrobium crumenatum Sw. with the analysis of flow cytometry

    Directory of Open Access Journals (Sweden)

    Upatham Meesawat

    2008-05-01

    Full Text Available Nuclear DNA content for the adult plants grown in a greenhouse and in vitro young plantlets of the pigeon orchid (Dendrobium crumenatum Sw. was analyzed using flow cytometry. The resulting 2C DNA values ranged from 2.30±0.14 pgto 2.43±0.06 pg. However, nuclear DNA ploidy levels of long-term in vitro plantlets were found to be triploid and tetraploid.These ploidy levels were confirmed by chromosome counting. Tetraploid individuals (2n = 4x = 76 had approximately two times DNA content than diploid (2n = 2x = 38 individuals. This variation may be due to prolonged cultivation and thepresence of exogenous plant growth regulators.

  3. Excitation conditions and energetics of the dense gas in M17 SW

    Science.gov (United States)

    Pérez-Beaupuits, J. P.; Güsten, R.; Spaans, M.; Ossenkopf, V.; Menten, K. M.; Requena-Torres, M. A.; Stutzki, J.; Wiesemeyer, H.; Guevara, C.

    2016-05-01

    The chemical and energetic conditions created by radiative feedback are probed with observations of multiple molecular transitions toward M17 SW. Extensive maps, including the 12CO J = 16 → 15, J = 12 → 11, and J = 11 → 10 lines, as well as the HCN J = 8 → 7 and HCO+ J = 9 → 8 transitions, were obtained with the dual band receiver GREAT on board the SOFIA airborne telescope, and with the ground based APEX and IRAM 30 m telescopes. These data provide extensive line spectral energy distributions (LSEDs) of the CO, HCN and HCO+ molecules (and their isotopologues). The excitation conditions of the three species are estimated simultaneously using the same density and temperature in a two-phase non-LTE radiative transfer model of the LSEDs.

  4. Trace element mapping of two Pyrenean chert deposits (SW Europe) by PIXE

    Energy Technology Data Exchange (ETDEWEB)

    Sánchez de la Torre, Marta, E-mail: marta.sanchez-de-la-torre@u-bordeaux-montaigne.fr [IRAMAT-CRP2A (UMR 5060), CNRS/Université Bordeaux Montaigne, Maison de l’Archéologie, Esplanade des Antilles, 33607 Pessac Cedex (France); SERP-Universitat de Barcelona, Montalegre St 6-8, 08001 Barcelona (Spain); Angyal, Anikó; Kertész, Zsófia [MTA Atomki, Institute for Nuclear Research, Hungarian Academy of Sciences, H-4026 Debrecen (Hungary); Dubernet, Stéphan; Le Bourdonnec, François-Xavier [IRAMAT-CRP2A (UMR 5060), CNRS/Université Bordeaux Montaigne, Maison de l’Archéologie, Esplanade des Antilles, 33607 Pessac Cedex (France); Csedreki, László; Furu, Enikő; Papp, Enikő; Szoboszlai, Zoltán; Szikszai, Zita [MTA Atomki, Institute for Nuclear Research, Hungarian Academy of Sciences, H-4026 Debrecen (Hungary)

    2017-06-01

    The geochemical character of two chert formations from the Pyrenean mountain range (SW Europe) was established by PIXE analyses. While it was not possible to distinguish the formations through reference to major and minor elements, some variations were revealed at the trace elemental level. In order to determine if these elements are associated with the Si matrix or to the contents of a specific inclusion, elemental maps were acquired and the elemental composition of the identified inclusions were also determined. As a result, Sr, Ni and Zn are better represented in Montgaillard samples while Y, Hf, W and Zr are typical of Montsaunès cherts. Thanks to elemental maps it has been possible to determine that most of these characteristic elements are usually related to a specific inclusion content.

  5. Wave hindcast experiments in the Indian Ocean using MIKE 21 SW model

    Indian Academy of Sciences (India)

    P G Remya; Raj Kumar; Sujit Basu; Abhijit Sarkar

    2012-04-01

    Wave prediction and hindcast studies are important in ocean engineering, coastal infrastructure development and management. In view of sparse and infrequent in-situ observations, model derived hindcast wave data can be used for the assessment of wave climate in offshore and coastal areas. In the present study, MIKE 21 SW Model has been used to carry out wave hindcast experiments in the Indian Ocean. Model runs have been made for the year 2005 using QuickSCAT scatterometer winds blended with ECMWF model winds. In order to study the impact of southern ocean swells, the model has been run in two different domains, with the southern boundary being shifted far south for the Domain 60S model. The model simulated wave parameters have been validated by comparing with buoy and altimeter data and various statistical yardsticks have been employed to quantify the validation. Possible reason for the poorer performance of the model in the Arabian Sea has also been pointed out.

  6. Late Pleistocene Climate Events and The Origin of Agriculture In SW Asia

    Science.gov (United States)

    Rossignol-Strick, M.

    In the Eastern Mediterranean sea, the climate succession of the last deglaciation is documented and dated in marine cores by the d18-O variation of foraminiferal cal- cite and pollen records. The Last Glacial Maximum is identified by a large abundance of grass pollen from a prairie-type vegetal cover with low annual precipitation in the mountainous north and east borderlands of the sea, where the pollen mainly origi- nates. During the first phase of the last deglaciation, the Bolling/Allerod chronozone, the moisture availability increases and makes possible the spread of a deciduous for- est, as shown by the increasing pollen abundance of the deciduous oak. The cold and arid Younger Dryas is identified by a reversal to semi-desert conditions, with the in- crease of sage-brush (Artemisia) and the saline-tolerant Chenopodiaceae. The climate of the earliest Holocene is Optimum for at least 3000 years (9000-6000yr BP), with the largest spread of the deciduous forest at low-middle elevations signalling wet sum- mers and of the Pistacia woodland at low elevations signalling mild, no-frost winters. This is the time when the most recent sapropel deposited in the eastern Mediterranean under anoxic bottom conditions generated by a surface lid of lower salinity due to the concomitant largest floods of the Nile River fed by the strongest African monsoon rains in the Ethiopian Highlands. In SW Asia, the pollen records of lakes and marshes have been correlated with those of the marine cores, thereby obtaining a robust time-frame. In that area, the archaeo- logical data of human settlements are independently dated by 14C. Thus the archaeo- logical succession can be securely set against the well-dated climatic succession. The Late Palaeolithic populations of SW Asia were wandering hunter-gatherers in the prairies of the Last Glacial Maximum, where they already collected wild wheat, barley and fruit. With the Bolling/Allerod wetter and warmer climate, they began to settle in

  7. Complete genome sequence of Kangiella koreensis type strain (SW-125T)

    Energy Technology Data Exchange (ETDEWEB)

    Han, Cliff [Los Alamos National Laboratory (LANL); Sikorski, Johannes [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Lapidus, Alla L. [Joint Genome Institute, Walnut Creek, California; Nolan, Matt [Joint Genome Institute, Walnut Creek, California; Glavina Del Rio, Tijana [Joint Genome Institute, Walnut Creek, California; Tice, Hope [Joint Genome Institute, Walnut Creek, California; Cheng, Jan-Fang [Joint Genome Institute, Walnut Creek, California; Lucas, Susan [Joint Genome Institute, Walnut Creek, California; Chen, Feng [Joint Genome Institute, Walnut Creek, California; Copeland, A [U.S. Department of Energy, Joint Genome Institute; Ivanova, N [U.S. Department of Energy, Joint Genome Institute; Mavromatis, K [U.S. Department of Energy, Joint Genome Institute; Ovchinnikova, Galina [U.S. Department of Energy, Joint Genome Institute; Pati, Amrita [U.S. Department of Energy, Joint Genome Institute; Bruce, David [Joint Genome Institute, Walnut Creek, California; Goodwin, Lynne A. [Los Alamos National Laboratory (LANL); Pitluck, Sam [Joint Genome Institute, Walnut Creek, California; Chen, Amy [Joint Genome Institute, Walnut Creek, California; Palaniappan, Krishna [Joint Genome Institute, Walnut Creek, California; Land, Miriam L [ORNL; Hauser, Loren John [ORNL; Chang, Yun-Juan [ORNL; Jeffries, Cynthia [Oak Ridge National Laboratory (ORNL); Chain, Patrick S. G. [Lawrence Livermore National Laboratory (LLNL); Saunders, Elizabeth H [Los Alamos National Laboratory (LANL); Brettin, Thomas S [ORNL; Goker, Markus [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Tindall, Brian [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Bristow, James [Joint Genome Institute, Walnut Creek, California; Eisen, Jonathan [Joint Genome Institute, Walnut Creek, California; Markowitz, Victor [Joint Genome Institute, Walnut Creek, California; Hugenholtz, Philip [U.S. Department of Energy, Joint Genome Institute; Kyrpides, Nikos C [Joint Genome Institute, Walnut Creek, California; Klenk, Hans-Peter [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Detter, J. Chris [Joint Genome Institute, Walnut Creek, California

    2009-11-01

    Kangiella koreensis (Yoon et al. 2004) is the type species of the genus and is of phylogenetic interest because of the very isolated location of the genus Kangiella in the gammaproteobac-terial order Oceanospirillales. K. koreensis SW-125T is a Gram-negative, non-motile, non-spore-forming bacterium isolated from tidal flat sediments at Daepo Beach, Yellow Sea, Ko-rea. Here we describe the features of this organism, together with the complete genome se-quence, and annotation. This is the first completed genome sequence from the genus Kangiel-la and only the fourth genome from the order Oceanospirillales. This 2,852,073 bp long sin-gle replicon genome with its 2647 protein-coding and 48 RNA genes is part of the Genomic Encyclopedia of Bacteria and Archaea project.

  8. Saddle-shaped reticulate Nummulites from Early Oligocene rocks of Khari area, SW Kutch, India

    Indian Academy of Sciences (India)

    S Sengupta; Sampa Sarkar; S Mukhopadhyay

    2011-04-01

    Saddle-shaped reticulate Nummulites from the Early Oligocene rocks of Khari area, SW Kutch, India is reported here for the first time. Unusual shape of this Nummulites is due to the curved nature of the coiling plane, indicating space constrained postembryonic test growth. With regular development of chambers, septa and septal filaments, the saddle-shaped Nummulites constitutes the third morphotype of N. cf. fichteli Michelotti form A. Other morphotypes of the species reported earlier include inflated lenticular and conical tests. Multiple morphotypes of N. cf. fichteli form A indicates varied test growth in response to substrate conditions. Morphological variability exhibited by N. cf. fichteli form A from Kutch and some Early Oligocene reticulate Nummulites from the Far East are comparable. This faunal suite is morphologically distinct from the contemporary reticulate Nummulites of the European localities.

  9. Enhanced Southern Westerly Activity During the Last Glacial Interglacial Transition in SW Patagonia

    Science.gov (United States)

    Moreno, P. I.; Villa-Martinez, R. P.; Cardenas, M. L.; Moy, C. M.

    2008-12-01

    Much of the ongoing controversy regarding synchrony or bipolar asynchrony has centered on the timing and structure of temperature changes during the Last Glacial Interglacial Transition (LGIT) in the southern mid- latitudes, in particular the Patagonian region (40°-56°S) of South America. South America is the only continuous continental landmass in the Southern Hemisphere that intersects the entire westerly wind belt and lies in the critical climatic interface between mid- to high latitudes. The region between 50°- 55°S is of particular interest considering its proximity to the polar front and the southern margin of the westerly winds, and the possibility of monitoring paleoclimate changes at or near this important oceanic- atmospheric boundary. Present and past climate studies, including modeling simulations, have emphasized that interactions between changes in the Antarctic Circumpolar Current, the southern westerly winds, sea ice, and the polar front are important drivers for deep ocean circulation changes, variations in atmospheric CO2, and equator-to-pole temperature and pressure gradients. Yet, the behavior of the westerly winds and the adjacent Southern Ocean during the LGIT is still poorly understood despite their fundamental influence on modern hemispheric and global climate. In this study we compare sediment cores from small closed-basin lakes and a bog from the Ultima Esperanza area of SW Patagonia (52°S), an area affected solely by the southern westerlies. Lake sediment cores from three lakes show lacustrine sedimentation over the last 17,000 years. In contrast, the Dumestre bog shows subaerial peat deposition since 15 ka interrupted by a prominent lacustrine phase dated between 14.5-11.5 ka. During this interval palynological records indicate the preponderance of cold-resistant herbs, along with aquatic taxa, followed by a rapid expansion of Nothofagus woodlands/forests, a lake regressive phase in Dumestre, and disappearance of laminated calcite

  10. Sedimentology models from activity concentration measurements: application to the "Bay of Cadiz" Natural Park (SW Spain).

    Science.gov (United States)

    Ligero, R A; Vidal, J; Meléndez, M J; Hamani, M; Casas-Ruiz, M

    2009-03-01

    A previous study on seabed sediments of the Bay of Cadiz (SW of Spain) enabled us to identify several relations between sedimentological variables and activity concentrations of environmental radionuclides such as (137)Cs, (226)Ra, (232)Th and (40)K. In this paper the study has been extended to a large neighbouring inter-tidal area in order to establish if the above mentioned models can be generalized. As a result we have determined that the measured activity concentrations are closely to the values predicted by the theoretical models (correlation coefficient range=0.85-0.93). Furthermore, the proposal model for granulometric facies as a function of activity concentrations of the abovementioned radionuclides provides for the sediments distribution a representation which agrees with the values of the tidal energy distribution obtained using numeric models calibrated with experimental data from current meters and water level recorders.

  11. JVLA Observations of IC 348SW: Compact Radio Sources and their Nature

    CERN Document Server

    Rodriguez, L F; Palau, A

    2014-01-01

    We present sensitive 2.1 and 3.3 cm JVLA radio continuum observations of the region IC 348 SW. We detect a total of 10 compact radio sources in the region, of which seven are first reported here. One of the sources is associated with the remarkable periodic time-variable infrared source LRLL 54361, opening the possibility of monitoring this object at radio wavelengths. Four of the sources appear to be powering outflows in the region, including HH 211 and HH 797. In the case of the rotating outflow HH 797 we detect at its center a double radio source, separated by $\\sim3"$. Two of the sources are associated with infrared stars that possibly have gyrosynchrotron emission produced in active magnetospheres. Finally, three of the sources are interpreted as background objects.

  12. 基于SW/Simulation制动闸蝶形弹簧的受力分析

    Institute of Scientific and Technical Information of China (English)

    魏静

    2013-01-01

    According to the force of the disc spring of the hydraulic disc brake this paper analysis the butterfly spring with the SW/Simulation. We got the picture of Stress diagram and fatigue damage map which provide the basis for the design of the device of the brake failure detection.%  根据液压盘式制动器中制动闸蝶形弹簧组的受力实际,应用Solid Works有限元分析模块,对蝶形弹簧进行有限元分析,得出蝶形弹簧的应力图、疲劳损坏图。为制动器蝶形弹簧组失效的检测装置的设计提供依据。

  13. Study of the period changes in SW Dor, an RR Lyrae type star with Blazhko effect

    Science.gov (United States)

    Berdnikov, L. N.; Kniazev, A. Y.; Dambis, A. K.; Kravtsov, V. V.; Sefako, R.

    2016-09-01

    In 2012-2014 we acquired 1569 CCD BVIc frames for the RR Lyrae type variable SW Dor with the 76-cm telescope of the South African Astronomical Observatory (SAAO) and 1-m telescopes of Las Cumbres Observatory Global Telescope network (LCOGT). Our observations showed a large scatter in the resulting phased light curve, especially near maximum brightness, which allowed us to reveal the Blazhko effect with a period of ˜80.9d. To study the pulsation period changes, we used all the available observations including the 1299 magnitude estimates from the digitized plate library of Harvard University (the DASCH project), which allowed us to construct the O-C diagram spanning a 125-year long time interval and discover for the first time at least three abrupt changes of the pulsation period.

  14. Commissioning of a 6 MeV X-Band SW Accelerating Guide

    CERN Document Server

    Jin, Q; Sun, X; Tao, X; Tong, D

    2004-01-01

    A 6 MeV, X-band on-axis SW electron linear accelerating guide is being developed in Accelerator laboratory of Tsinghua University. It can be suitable for portable radiation therapy and radiography. The design, manufacture and high power test of the guide are given in this paper. The guide is 38 cm long and contains 25 accelerating cells with 24 coupling cells, operated in the π/2 mode. The RF power source is a pulsed magnetron at 9300 MHz with 1.5 MW peak power. The results of beam tests are following: the electron energy is more than 6 MeV at 50 mA and focal spot size is less than φ 1.5 mm without any focusing solenoid.

  15. JVLA observations of IC 348 SW: Compact radio sources and their nature

    Energy Technology Data Exchange (ETDEWEB)

    Rodríguez, Luis F.; Zapata, Luis A.; Palau, Aina, E-mail: l.rodriguez@crya.unam.mx, E-mail: l.zapata@crya.unam.mx, E-mail: a.palau@crya.unam.mx [Centro de Radioastronomía y Astrofísica, UNAM, Apdo. Postal 3-72 (Xangari), 58089 Morelia, Michoacán (Mexico)

    2014-07-20

    We present sensitive 2.1 and 3.3 cm Jansky Very Large Array radio continuum observations of the region IC 348 SW. We detect a total of 10 compact radio sources in the region, 7 of which are first reported here. One of the sources is associated with the remarkable periodic time-variable infrared source LRLL 54361, opening the possibility of monitoring this object at radio wavelengths. Four of the sources appear to be powering outflows in the region, including HH 211 and HH 797. In the case of the rotating outflow HH 797, we detect a double radio source at its center, separated by ∼3''. Two of the sources are associated with infrared stars that possibly have gyrosynchrotron emission produced in active magnetospheres. Finally, three of the sources are interpreted as background objects.

  16. Monitoring physical properties of a submarine groundwater discharge source at Kalogria Bay, SW Peloponnissos, Greece

    Science.gov (United States)

    Karageorgis, A. P.; Papadopoulos, V. P.; Georgopoulos, D.; Kanellopoulos, Th. D.; Papathanassiou, E.

    2012-04-01

    An impressive SGD in Kalogria Bay (SW Peloponnissos) was surveyed for the first time in 2006, revealing the existence of 2 major and 2 minor point sources of freshwater (salinity ~l-2); the discharge was ~ 1000 m3 h-1. The major point source was located in a karstic cavity at 25 m depth. In July 2009, and for a period of one year, the site was monitored intensively. During summer, the underwater discharge was not very strong, the water was flowing from many dispersed points, and salinity range was 20-36. During autumn and winter, flow velocity increased considerably (> 1 m s-1), and the SGDs discharged water of low salinity (< 2). Gradually, the smaller SGDs ceased their operation, and the major SGD emanated brackish water during spring and summer, thus hampering the possibilities of freshwater exploitation, in a touristic area which suffers from great aridity and water demand is high during summer.

  17. Monitoring physical properties of a submarine groundwater discharge source at Kalogria Bay, SW Peloponnissos, Greece

    Directory of Open Access Journals (Sweden)

    Papathanassiou E.

    2012-04-01

    Full Text Available An impressive SGD in Kalogria Bay (SW Peloponnissos was surveyed for the first time in 2006, revealing the existence of 2 major and 2 minor point sources of freshwater (salinity ~l-2; the discharge was ~ 1000 m3 h−1. The major point source was located in a karstic cavity at 25 m depth. In July 2009, and for a period of one year, the site was monitored intensively. During summer, the underwater discharge was not very strong, the water was flowing from many dispersed points, and salinity range was 20–36. During autumn and winter, flow velocity increased considerably (> 1 m s−1, and the SGDs discharged water of low salinity (< 2. Gradually, the smaller SGDs ceased their operation, and the major SGD emanated brackish water during spring and summer, thus hampering the possibilities of freshwater exploitation, in a touristic area which suffers from great aridity and water demand is high during summer.

  18. 法国Triangle(三角)新款Magellan Concerto SW2音箱

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    拥有超过25年发展历史的法国Triangle(三角)音响公司,以更为创新的设计理念和技术,于2006年底推出了新一代旗舰Magellan系列音箱,Concerto(协奏曲)SW2是率先出现的一款。在2006年底的广州白天鹅音响大展上,法国三角牌的老板Renaud de Vergnette先生和亚洲区业务经理Remy Bellemer先生向我刊介绍了这款寄予了众多希望的新产品。

  19. Evolutionary analysis of tomato Sw-5 resistance-breaking isolates of Tomato spotted wilt virus.

    Science.gov (United States)

    López, Carmelo; Aramburu, José; Galipienso, Luis; Soler, Salvador; Nuez, Fernando; Rubio, Luis

    2011-01-01

    Tomato spotted wilt virus (TSWV) causes severe economic losses in many crops worldwide and often overcomes resistant cultivars used for disease control. Comparison of nucleotide and amino acid sequences suggested that tomato resistance conferred by the gene Sw-5 can be overcome by the amino acid substitution C to Y at position 118 (C118Y) or T120N in the TSWV movement protein, NSm. Phylogenetic analysis revealed that substitution C118Y has occurred independently three times in the studied isolates by convergent evolution, whereas the substitution T120N was a unique event. Analysis of rates of non-synonymous and synonymous changes at individual codons showed that substitution C118Y was positively selected.

  20. Neogene to recent contraction and basin inversion along the Nubia-Iberia boundary in SW Iberia

    Science.gov (United States)

    Ramos, Adrià; Fernández, Oscar; Terrinha, Pedro; Muñoz, Josep Anton

    2017-02-01

    The SW of Iberia is currently undergoing compression related to the convergence between Nubia and Iberia. Multiple compressive structures, and their related seismic activity, have been documented along the diffuse Nubia-Iberia plate boundary, including the Gorringe bank west of the Gulf of Cadiz, and the Betic-Rif orogen to the east. Despite seismic activity indicating a dominant compressive stress along the Algarve margin in the Gulf of Cadiz, the structures at the origin of this seismicity remain elusive. This paper documents the contractional structures that provide linkage across the Gulf of Cadiz and play a major role in defining the present-day seismicity and bathymetry of this area. The structures described in this paper caused the Neogene inversion of the Jurassic oblique passive margin that formed between the central Atlantic and the Ligurian Tethys. This example of a partially inverted margin provides insights into the factors that condition the inversion of passive margins.

  1. Young green turtles, Chelonia mydas, exposed to plastic in a frontal area of the SW Atlantic.

    Science.gov (United States)

    González Carman, Victoria; Acha, E Marcelo; Maxwell, Sara M; Albareda, Diego; Campagna, Claudio; Mianzan, Hermes

    2014-01-15

    Ingestion of anthropogenic debris represents an important threat to marine turtle populations. Information has been limited to inventories of debris ingested and its consequences, but why ingestion occurs and the conditions that enable it are less understood. Here we report on the occurrence of plastic ingestion in young green turtles (Chelonia mydas) inhabiting the Río de la Plata (SW Atlantic). This estuarine area is characterized by a frontal system that accumulates anthropogenic debris. We explored exposure of green turtles to plastic and its ingestion via debris distribution, habitat use and digestive tract examination. Results indicated that there is considerable overlap of frontal accumulated plastic and core foraging areas of the animals. Exposure results in ingestion, as shown by the high frequency of plastic found in the digestive tracts. The Río de la Plata estuarine front is an area of conservation concern for young green turtles.

  2. Comportement de Stylosanthes guianensis (Aubl. Sw. dans la basse Ruzizi et le Mosso (Burundi

    Directory of Open Access Journals (Sweden)

    Vancoppenolle, R.

    1984-01-01

    Full Text Available Requirements of Stylosanthes guianensis (Aubl Sw in lower Ruzizi and Mosso (Burundi. This paper describes the requirements of Stylosanthes guianensis in two ecological regions : Mosso (1 280 m alt. and lower Ruzizi (800 m alt.. This legume was introduced in 1953 into the grasslands of the east and in 1970 into lower Ruzizi, with the aim of improving the value of the natural pastures using leguminous plants. At Mosso, soil and climatic conditions were favourable for Stylosanthes and it grew well. However, since 1981. Anthracnose has severely reduced its growth and until a solution is found its general introduction will not be possible. In lower Ruzizi plant development was limited by low rainfall (670, 4 mm per year and soils with a low water retention capacity (sand dunes. For this region, it is necessary to identify cultivars resistant to drought and devise a method of establishing these cultivars on sand dunes.

  3. High-pressure metamorphism in the Early Variscan subduction complex of the SW Iberian Massif

    Science.gov (United States)

    Rubio Pascual, Francisco J.; Matas, Jerónimo; Martín Parra, Luis M.

    2013-04-01

    Several units exposed in the boundary area of the Ossa Morena Zone (OMZ) and the South Portuguese Zone (SPZ) preserve petrographic and thermobarometric evidence for an early metamorphic episode (M1), developed under a high-P, low to intermediate-T gradient, related to Early Variscan subduction in the SW Iberian Massif. In the OMZ, these are the Cubito-Moura Unit (Pmin ~ 9.2 kbar and T = 395 ± 45 °C), blueschists from its basal mélange (Pmin ~ 12.4 kbar and T = 310 ± 11 °C), and the underlying Fuenteheridos Group (P = 10.9 ± 0.4 kbar and T = 449 ± 31 °C). The equivalent units in the SPZ are the La Minilla Formation (P = 8.7 ± 0.4 kbar and T = 388 ± 16 °C) and the lawsonite pseudomorphs-bearing Pulo do Lobo Formation. All these units formed part of an approximately NE verging orogenic wedge (present coordinates) developed by the accretion of subducted slabs of the outermost margin of Gondwana and other elements of the Rheic Ocean realm, from at least the Middle Devonian to the lowermost Tournaisian. High-pressure rocks were subsequently emplaced on more internal zones of the OMZ that only experienced a younger high-T, low to intermediate-P metamorphism (M2). This high-T event was coeval with magmatic activity from the uppermost Devonian to the Middle Mississippian, probably as a consequence of transtensional lithospheric thinning and/or delamination of the lower crust and mantle lithosphere of the Gondwana margin. Pre-Late Devonian synorogenic sedimentation in forearc and back-arc basins of the subduction complex evolved to a Late Devonian-Middle Mississippian foreland basin system in early collisional stages. Finally, a new Middle-Late Mississippian fold-and-thrust belt with opposite (SW) vergence and new foreland basins developed during late collisional stages.

  4. The elusive nature of the Rheic Ocean suture in SW Iberia

    Science.gov (United States)

    Pérez-Cáceres, I.; Martínez Poyatos, D.; Simancas, J. F.; Azor, A.

    2015-12-01

    The Rheic Ocean suture resulted from pre-Carboniferous oceanic subduction followed by Late Devonian-Carboniferous Variscan collision. In SW Iberia, this suture has been classically located along the boundary between the Ossa-Morena and South Portuguese Zones based on the presence of three units: (i) a conspicuous metamafic unit (Beja-Acebuches) that crops out along this boundary and has been interpreted as a pre-Carboniferous Rheic Ocean ophiolite; (ii) a low-grade metasedimentary unit with minor mid-ocean ridge basalt-like lithologies (Pulo do Lobo unit), thought to represent a Rheic Ocean subduction-related accretionary prism; and (iii) the allochthonous Cubito-Moura unit that contains high-pressure and ophiolitic-like rocks. We report new structural and geochronological data that allow us to reinterpret the origin and internal structure of the Beja-Acebuches and the Pulo do Lobo units. Thus, both the Beja-Acebuches protoliths and the Pulo do Lobo metabasalts would have been formed in the context of an intracollisional extensional stage that interrupted the Variscan collision at early Carboniferous time, after the Rheic Ocean consumption, and the first continental collision. Later on, collision was resumed in an oblique left-lateral regime that gave way to coeval frontal (folds and thrusts) and lateral (shear zones and strike-slip faults) structures, with variable pressure-temperature conditions and space distribution along time. As a consequence of the superposition of transtension and complex transpression, the Rheic suture in SW Iberia has an obscure nearly cryptic appearance.

  5. Possible petrological controls on the location and time scale of slow slip in SW Japan

    Science.gov (United States)

    Wallis, S.; Mizukami, T.; Yokoyama, H.; Hiramatsu, Y.; Arai, S.; Kawahara, H.; Nagaya, T.

    2014-12-01

    To examine the possibility that there was a petrological control on the location and nature of episodic tremor and slip (ETS), we compared the petrological characteristics of wedge mantle material to the results of recent geophysical observations in the Shikoku area, southwest Japan. This study revealed a close relationship between predicted mineral assemblages in the mantle wedge and the characteristics of slow slip behaviour recorded in the Shikoku area: Short-term ETSs take place in the antigorite +olivine stability field and silent long-term slow slip events (SSEs) take place in the antigorite+brucite stability field. The petrology of the mantle wedge may be an important control on the fluid pressure along the subduction interface and influence the time scales of SSEs. The Cretaceous Sanbagawa oceanic subduction complex of SW Japan preserves fragments of the former mantle wedge in contact with subducted slab units. P-T paths and peak P-T conditions show this belt formed as the result of subduction of a young slab under relatively warm conditions. These characteristics make the Sanbagawa belt a good analogue to modern warm subduction zones such as the Philippine Sea subduction zone beneath SW Japan and offer the possibility of directly examining the former plate boundary. Mantle wedge units derived from shallow depths show evidence for widely developed primary brucite and antigorite. In contrast, units derived from greater depths and higher peak temeratures consist dominantly of antigorite and olivine. Observations of the natural serpentinites suggest that the shallow serpentinite with brucite shows higher absorbency of water and provides fluid pathways that can reduce the fluid pore pressure on the subduction boundary.

  6. Seismic and gravity anomaly evidence of large-scale compressional deformation off SW Portugal

    Science.gov (United States)

    Cunha, T. A.; Watts, A. B.; Pinheiro, L. M.; Myklebust, R.

    2010-04-01

    Multi-channel seismic and gravity anomaly data have been used to determine the extent of compressional deformation along the SW Portugal rifted continental margin and place constraints on the long-term (> 1 M.a.) strength of the lithosphere. The seismic sections suggest that the region of compressional deformation is broad (˜ 100 km) and has been active since the Miocene. Integration with recently compiled high-resolution bathymetric data shows that the main thrust front is located along the base of the continental slope, between north of the Gorringe Bank and the Setúbal Canyon. Gravity data show that the thrust front is associated with a narrow isostatic anomaly 'high' of up to 70 mGal that is flanked on its NW edge by a broad 'low' of up to 20 mGal. This high-low 'couple' can be explained by compressional loading of extended continental lithosphere that increased its flexural strength (or equivalent elastic thickness, Te) since rifting. Based on combined 2-D backstripping and gravity modelling techniques we estimate a Te of ˜ 10 km during the main stretching episode, in the Late Jurassic (maybe earliest Cretaceous?), and of 35-50 km during the Miocene to Recent compression. The existence of a broad region of deformation off SW Portugal together with a strong lithosphere have implications for the rupture models of large earthquakes in the region, such as the 1755 Great Lisbon earthquake, particularly when accounting for a complex, multiple rupture in faults which cut through lithosphere of distinct nature and origin, as appears to be required by modellers to explain the historical observational data.

  7. Apoptosis induction with polo-like kinase-1 antisense phosphorothioate oligodeoxynucleotide of colon cancer cell line SW480

    Institute of Scientific and Technical Information of China (English)

    Yu Fan; Shu Zheng; Ze-Feng Xu; Jia-Yi Ding

    2005-01-01

    AIM: To investigate the effects of polo-like kinase-1 (PLK1) antisense phosphorothioate oligodeoxynucleotide (ASODN) on apoptosis and cell cycle of human colon cancer cell line 5W480.METHODS: After SW480 colon cancer cells were transfected with PLK1 ASODN, Northern and Western blot analyses were used to examine PLK1 gene expression in cancer cells. We studied apoptosis using terminal uridine deoxynucleotidyl nick end labeling. Apoptosis and cell cycle of SW480 cells were examined by fluorescence-activated cell sorter scan.RESULTS: The levels of PLK1 mRNA and protein were greatly inhibited by PLK1 ASODN in SW480 cancer cells transfected with PLK1 ASODN. Apoptosis index (AI) induced PLK1 ASODN in a time- and dose-dependent manner.Results from FLM showed that sub-2N DNA content of transfected cancer cells was significantly increased and arrested at G2/M compared with control groups.CONCLUSION: PLK1 ASODN can induce apoptosis of human colon cancer cell line SW480.

  8. Late-Quaternary variations in clay minerals along the SW continental margin of India: Evidence of climatic variations

    Digital Repository Service at National Institute of Oceanography (India)

    Chauhan, O.S.; Sukhija, B.S.; Gujar, A.R.; Nagabhushanam, P.; Paropkari, A.L.

    Down-core variations in illite, chlorite, smectite and kaolinite (the major clays) in two sup(14)C-dated cores collected along the SW continental margin of India show that illite and chlorite have enhanced abundance during 20-17, 12.5, 11-9.5, and 5...

  9. Impact of age on the cerebrovascular proteomes of wild-type and Tg-SwDI mice.

    Directory of Open Access Journals (Sweden)

    James L Searcy

    Full Text Available The structural integrity of cerebral vessels is compromised during ageing. Abnormal amyloid (Aβ deposition in the vasculature can accelerate age-related pathologies. The cerebrovascular response associated with ageing and microvascular Aβ deposition was defined using quantitative label-free shotgun proteomic analysis. Over 650 proteins were quantified in vessel-enriched fractions from the brains of 3 and 9 month-old wild-type (WT and Tg-SwDI mice. Sixty-five proteins were significantly increased in older WT animals and included several basement membrane proteins (nidogen-1, basement membrane-specific heparan sulfate proteoglycan core protein, laminin subunit gamma-1 precursor and collagen alpha-2(IV chain preproprotein. Twenty-four proteins were increased and twenty-one decreased in older Tg-SwDI mice. Of these, increases in Apolipoprotein E (APOE and high temperature requirement serine protease-1 (HTRA1 and decreases in spliceosome and RNA-binding proteins were the most prominent. Only six shared proteins were altered in both 9-month old WT and Tg-SwDI animals. The age-related proteomic response in the cerebrovasculature was distinctly different in the presence of microvascular Aβ deposition. Proteins found differentially expressed within the WT and Tg-SwDI animals give greater insight to the mechanisms behind age-related cerebrovascular dysfunction and pathologies and may provide novel therapeutic targets.

  10. The sudden appearance of Aeolidiella glauca (Gastropoda: Opisthobranchia) in lake Greveliningen (S.W. Netherlands) in 1983 and 1984

    NARCIS (Netherlands)

    Dekker, R.

    1985-01-01

    In 1983 and 1984 a population of the nudibranch Aeolidiella glauca (Alder & Hancock, 1845) was found in the saline Lake Grevelingen (S.W. Netherlands). The number of specimens observed exceeds by far the total number previously recorded from the Dutch coast. Field observations on food intake suggest

  11. Evaluation of thermal performance in fields subjected to steam injection (SW-SAGD mode), Orinoco oil belt, Venezuela

    Energy Technology Data Exchange (ETDEWEB)

    Armas, F.; Mago, R.; Franco, L.; Rodriguez, J.; Gil, E. [PDVSA EandP (Venezuela)

    2011-07-01

    The first well to operate the SW-SAGD process in the Orinoco oil belt in Venezuela was built in 2006 by Petroleos de Venezuela S.A (PDVSA). SW-SAGD is a thermal recovery process consisting in the injection of steam through a horizontal well pipe insulation. In order to follow the behavior of steam and the movement of heated fluids in such a process better, PDVSA installed a monitoring system composed of high temperature fiber optic and thermocouple type sensors. The aim of this paper is to assess the thermal behavior of reservoirs in wells under the SW-SAGD process. A pilot test has been conducted over the last 3 years. Results show an increase in production and estimations show a recovery factor twice as high as in other wells. This study demonstrated that SW-SAGD is an excellent alternative solution to stimulate reservoirs in the Orinoco oil belt and valuable information on the reservoir's thermal behavior was established.

  12. swDMR: A Sliding Window Approach to Identify Differentially Methylated Regions Based on Whole Genome Bisulfite Sequencing.

    Directory of Open Access Journals (Sweden)

    Zhen Wang

    Full Text Available DNA methylation is a widespread epigenetic modification that plays an essential role in gene expression through transcriptional regulation and chromatin remodeling. The emergence of whole genome bisulfite sequencing (WGBS represents an important milestone in the detection of DNA methylation. Characterization of differential methylated regions (DMRs is fundamental as well for further functional analysis. In this study, we present swDMR (http://sourceforge.net/projects/swDMR/ for the comprehensive analysis of DMRs from whole genome methylation profiles by a sliding window approach. It is an integrated tool designed for WGBS data, which not only implements accessible statistical methods to perform hypothesis test adapted to two or more samples without replicates, but false discovery rate was also controlled by multiple test correction. Downstream analysis tools were also provided, including cluster, annotation and visualization modules. In summary, based on WGBS data, swDMR can produce abundant information of differential methylated regions. As a convenient and flexible tool, we believe swDMR will bring us closer to unveil the potential functional regions involved in epigenetic regulation.

  13. H.W. Menard 1920”1986

    Science.gov (United States)

    Revelle, Roger

    A photograph of Bill Menard was on the cover of the January 7, 1986, issue of Eos, and on pages 8 and 9 of that issue, Marcia McNutt's citation in presenting the 1985 Bowie Medal and Bill's response were published. Only a month later, on February 9, Bill died of cancer. Today we remember in joy and sorrow the life of our friend: joy because he was able to do so much and live so intensely throughout the 40 years of his career as a seagoing scientist, and sorrow because we miss his warm, loving presence.Bill was an explorer, a scientist, a scholar, and a poet. He had the seeing eye, the powerful imagination, and the hard-working energy that are necessary to be either a scientist or a poet or, as in his case, both. He was a scholar because unlike many scientists, he was self-conscious and introspective about his science. Consequently, he was interested not only in the discovery of new scientific facts and the development of hypotheses to explain them but also in the history of his science, the individuals living and dead who had contributed to it, and the romance and adventure of life as a scientific sailor. His book Anatomy of an Expedition (McGraw-Hill, 1969) and his manuscript, about to be published by Princeton University Press, called Ocean of Truth are both poetic evocations of an oceanographer's life at sea and on the beach. In all that he did, he was generous to his colleagues and honest with them and with himself.

  14. CPR1000核电机组重要厂用水泵功率变化对应急柴油发电机负荷影响分析%Analysis on the impact Of power variation Of essential service water (SEC)pumps of CPR1000 nuclear power units on the loads Of emergency diesel generators

    Institute of Scientific and Technical Information of China (English)

    马志华; 南卫; 李岚

    2011-01-01

    Emergency diesel generators of nuclear power plant (NPP) are designed to provide power to emergency plant equipments with nuclear safety function in case of the failure of both off -site operating power and stand-by power.As the loads of emergency diesel generators constantly increased with the increase of CPR1000 nuclear power units, the calculated capacity of emergency diesel generators was very close to or even exceeded the maximum capacity of the current unit types, which caused much difficulty for the design and procurement work of the follow-up projects.The power of essential service water (SEC) pumps is an integral part of emergency diesel generator loads.Taking certain nuclear power project in Guangxi coastal area as an example, this thesis aimed to find out the reasons for load increasing and offer an optimizing and improving methods to decrease the load power of emergency diesel generators through analyzing several important factors affecting on the power of essential service water(SEC) pumps, such as the values of the design basis temperature of the final heat sink (T7), the design basis flood level of the sea areas around the plant site and the site elevation, and the pump lift as well as the auxiliary generator power.%核电厂应急柴油发电机组是在厂外工作电源和备用电源均失去的情况下,为具有核安全功能的应急厂用设备提供电能.随着CPR1000核电机组数量的日益增多,应急柴油发电机组加载负荷也不断增大,致使柴油发电机组计算容量已经非常接近甚至超过目前所能使用机型的极限容量,给后续项目的设计和采购工作造成了极大的困难.重要厂用水(SEC)泵的功率是应急柴油发电机组加载负荷的一部分,以广西某沿海地区核电工程项目为例,通过对最终热阱设计基准水温(T)的取值,厂址海域设计基准洪水位,厂坪标高的确定,水泵扬程及配套电机功率的选取等几方面因素对SEC

  15. Mechanisms underlying aspirin-mediated growth inhibition and apoptosis induction of cyclooxygenase-2 negative colon cancer cell line SW480

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    AIM: To investigate the effects of aspirin (acetylsalicylic acid) on proliferation and apoptosis of colorectal can- cer cell line $W480 and its mechanism. METHODS: Cyclooxygenase (COX)-2 negative colorec- tal cancer cell line SW480 was treated with aspirin at concentrations of 2.5 retool/L, 5.0 retool/L, 10.0 mmol/L for different periods in vitro. Anti-proliferation effect of aspirin on SW480 was detected by 3-(4,5-dimeth- ylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cycle and apoptosis were observed by flow cytometry (FCM). Transmission electron microscope (TEM) was used for morphological study. Apoptosis-as- sociated genes were detected by immunohistochemical staining and Western blotting. RESULTS: Aspirin inhibited SW480 proliferation and induced apoptosis in a dose- and time-dependent manner. Treatment with different concentrations of aspirin significantly increased the proportions of cells at the G0/G1 phase and decreased the proportions of cells at the S- and G2/M phases in a concentration- dependent manner. Aspirin not only induced apoptosis but also caused cell necrosis at a high concentration as well. After treatment with aspirin, SW480 cells displayed typically morphological features of apoptosis and necrosis under TEM, and increased the Bcl-2 expression in cells, but the expression of Bax was down regulated. CONCLUSION: Aspirin inhibits proliferation and induces apoptosis of SW480 cells. Its anti-tumor mechanism may arrest cell cycle and shift Bax/Bcl-2 balance in cells.

  16. Cell death triggering and effector recognition by Sw-5 SD-CNL proteins from resistant and susceptible tomato isolines to Tomato spotted wilt virus.

    Science.gov (United States)

    De Oliveira, Athos Silva; Koolhaas, Ivo; Boiteux, Leonardo Silva; Caldararu, Octav F; Petrescu, Andrei-Jose; Oliveira Resende, Renato; Kormelink, Richard

    2016-12-01

    Only a limited number of dominant resistance genes acting against plant viruses have been cloned, and further functional studies of these have been almost entirely limited to the resistance genes Rx against Potato virus X (PVX) and N against Tobacco mosaic virus (TMV). Recently, the cell-to-cell movement protein (NSM ) of Tomato spotted wilt virus (TSWV) has been identified as the avirulence determinant (Avr) of Sw-5b-mediated resistance, a dominant resistance gene which belongs to the class of SD-CC-NB-LRR (Solanaceae domain-coiled coil-nucleotide-binding-leucine-rich repeat, SD-CNL) resistance genes. On transient expression of the NSM protein in tomato and transgenic Nicotiana benthamiana harbouring the Sw-5b gene, a hypersensitive cell death response (HR) is triggered. Here, it is shown that high accumulation of the Sw-5b protein in N. benthamiana leaves, achieved by co-expression of the Sw-5b protein with RNA silencing suppressors (RSSs), leads to auto-activity in the absence of NSM . In a similar approach, Sw-5a, the highest conserved paralogue of Sw-5b from Solanum peruvianum, also triggered HR by auto-activation, whereas the highest conserved orthologue from susceptible S. lycopersicum, named Sw-5a(S) , did not. However, neither of the last two homologues was able to trigger an NSM -dependent HR. Truncated and mutated versions of these Sw-5 proteins revealed that the NB-ARC [nucleotide-binding adaptor shared by Apaf-1 (from humans), R proteins and CED-4 (from nematodes)] domain is sufficient for the triggering of HR and seems to be suppressed by the SD-CC domain. Furthermore, a single mutation was sufficient to restore auto-activity within the NB-ARC domain of Sw-5a(S) . When the latter domain was fused to the Sw-5b LRR domain, NSM -dependent HR triggering was regained, but not in the presence of its own Sw-5a(S) LRR domain. Expression analysis in planta revealed a nucleocytoplasmic localization pattern of Sw-5b, in which the SD-CC domain seems to be

  17. Solasodine accumulation in regenerated plants of Solanum torvum Sw Acúmulo de solasodina em plantas micropropagadas de Solanum torvum Sw

    Directory of Open Access Journals (Sweden)

    C.B Moreira

    2010-03-01

    Full Text Available A nodal segment culture was developed in order to assess Solanum torvum Sw. regeneration and solasodine levels. The influence of auxins (indoleacetic acid, 1-Naphthaleneacetic acid and benzyl adenine on S. torvum growth in micropropagation was investigated. A nodal segment culture was initiated with seeds germinated in MS basal medium added of GA3 and grown in different concentrations of IAA, IAA + BAP and NAA + BAP. Sixty-day-old plants from the in vitro culture were collected, frozen and lyophilized; then, the methyl orange method was used to quantify solasodine for the spectrophotometric assay. The best results regarding plant regeneration and solasodine accumulation were obtained by using the MS basal medium without addition of plant growth regulators; however, there was great production of calluses presenting friable bases. Based on these results, cell cultures can be initiated from such calluses with application of other auxins and cytokinins to enhance solasodine production, besides different elicitors, light intensities and sucrose concentrations.A regeneração de Solanum torvum e a avaliação do conteúdo de solasodina foram os objetivos de cultura de segmentos nodais. A influência de auxinas (ácido 3-indolacético, ácido naftalenoacético e de 6-benzilaminopurina no crescimento de S. torvum na micropropagação foi investigado. Cultura de segmentos nodais foi iniciada por sementes germinadas em meio básico MS acrescido de GA3 e cultivadas em diferentes concentrações de AIA, AIA + BAP e ANA + BAP. Plantas da cultura in vitro com 60 dias foram coletadas, congeladas e liofilizadas e o método de alaranjado de metila foi utilizado para quantificação de solasodina para o ensaio espectrofotométrico. Os melhores resultados para regeneração vegetal e acúmulo de solasodina foram alcançados no meio MS sem adição de reguladores de crescimento havendo, porém grande produção de calos de base friáveis. Esses resultados mostram

  18. Roles of different CPR training modes in first aid skills of nurses at clinic%不同的CPR培训模式在门诊护士急救技能中的作用

    Institute of Scientific and Technical Information of China (English)

    于志红; 高丽红; 贾荣娟

    2015-01-01

    Objective To investigate the roles of different CPR training modes in first aid skills of nurses at clinic.Methods The teachers were trained.Standard CPR skill steps were videotaped and then the video was put onto the hospital network site so that the nurses at clinic can practice it on high simulation model while watching the video to achieve the homogeneity of training.Re-training assessment frequency was determined according to the nurse's length of service.The assessment results was linked to head nurse' management performance and individuals' year-end evaluation.Results Comparison between theory and skill scores after different training modes were carded out:taking examination immediately (ttheory =4.1362,tskill =5.0148,P <0.05); taking examination 6 months from then (ttheory =12.3327,tskill =11.6073,P <0.01);taking examination 12 months from then (ttheory=19.7291,tskill =23.27,P <0.01).Conclusion Practicing while watching video in combination with re-training assessment can let the nurses at clinic keep skillful in CPR in a long term.%目的 观察不同培训模式在门诊护士急救技能中的作用.方法 培训师资、将标准的CPR技能操作步骤录制成视频片放在医院内网网站上,让门诊护士利用高仿真模拟人边看边练,达到同质化培训;根据门诊护士工龄确定复训考核频次,并将考核成绩与护士长管理绩效和个人年终考评挂钩.结果 不同培训模式后理论和技能得分比较:立即考试(t'理论=4.1362;t'技能=5.0148,P<0.05);6个月考试(t理论=12.3327;t技能=11.6073,P<0.01);12个月考试(t理论=19.7291;t技能=23.27,P<0.01).结论 边看视频边练习培训结合复训考核能使门诊护士长期保持有效的CPR技能.

  19. Influences of the interferon induced transmembrane protein I on the proliferation, invasion, and metastasis of the colorectal cancer SW480 cell lines

    Institute of Scientific and Technical Information of China (English)

    HE Jing-dong; LUO Hong-lei; LI Jin; FENG Wan-ting; CHEN Long-bang

    2012-01-01

    Background Interferon-induced transmembrane protein 1 (IFITM1) has been identified as a molecular marker of the colorectal tumors; however its influences on the biological behaviors of the colorectal cancer cells are currently unknown.We aimed to study the influences of IFITM1 on the proliferation,invasion,and metastasis of the colorectal cancer SW480 cell lines.Methods We constructed IFITM1/pEGFP-C3 recombinant plasmids and transfected them into the colorectal cancer SW480 cell lines.IFITM1/pEGFP-C3 recombinant plasmids were identified by means of immunofluorescence,laser confocal scanning microscopy,and reverse transcription polymerase chain reaction.IFITM1/SW480 cells with stable over-expression of IFITM1 were confirmed by G418 screening.The influences of IFITM1 on the proliferation of the SW480 cell lines were investigated by MTT assay and tumor transplantation experiments in nude mice.Cell invasion experiments were performed to determine the invasion capacity of the IFITM1/SW480 cells.Matrix metalloproteinase 2 (MMP-2) and MMP-9 activities were detected by the gelatin zymographic analysis,and MMP-9 expression by the Western blotting analysis.Results IFITM1/pEGFP-C3 recombinant plasmids were successfully constructed in this study,and the IFITM1/SW480 cells with stable IFITM1 gene over-expression were confirmed by G418 screening.MTT results showed that the proliferation of the IFITM1/SW480 cells was significantly enhanced (P <0.01).Tumors were harvested from four weeks old mice.Tumor volumes were (1347.00±60.94) mm3,(1032.40±111.38) mm3 and (1018.78±28.83) mm3; and tumor weights were (1522.34±62.76) mg,(1137.78±97.22) mg and (1155.76±133.31) mg for mice inoculated with the IFITM1/SW480 cells,pEGFP-C3/SW480 cells and SW480 cells,respectively.Tumor volumes and weights from mice inoculated with the IFITM1/SW480 cells were significantly increased (P <0.01).In addition,the numbers of the SW480 cells and IFITM1/SW480 cells that migrated through Matrigel were

  20. Effects of calcium signaling on coagulation factor VIIa-induced proliferation and migration of the SW620 colon cancer cell line.

    Science.gov (United States)

    Wu, Ying; Wang, Jing; Zhou, Hong; Yu, Xiaoyan; Hu, Lichao; Meng, Fanlu; Jiang, Shuanghong

    2014-12-01

    Tissue factor (TF)/VIIa/protease‑activated receptor 2 (PAR2) has been shown to trigger the ERK1/2 signaling pathway. This was shown to be closely associated with the proliferation and migration of SW620 colon cancer cells; however, the detailed mechanisms remain unclear. The aim of the present study was to elucidate the effects of calcium signaling on the proliferation and migration of SW620 cells induced by coagulation factor VIIa. The results demonstrated that VIIa and PAR2 agonist PAR2‑AP increased [Ca2+]i in SW620 cells. In addition, VIIa‑and PAR2‑AP‑induced ERK1/2 activation was inhibited by thapsigargin (TG)‑induced depletion of intracellular Ca2+ stores and EGTA‑mediated removal of extracellular Ca2+. It was also identified that VIIa and PAR2‑AP‑induced proliferation and migration of SW620 cells was modulated by EGTA and TG. Taken together, the present results indicate that VIIa triggers calcium signaling in SW620 cells, in a TF‑dependent manner, which is critical for VIIa‑induced ERK1/2 activation in SW620 cells. These results suggested that calcium signaling had a vital role in the proliferation and migration of SW620 cells.