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Sample records for huxley eugenics review

  1. Eugenics: The Threat of the Feeble Minded.

    Science.gov (United States)

    Winzer, Margaret; O'Connor, Anne

    1982-01-01

    The history of the eugenics movement is reviewed. The authors conclude that, despite changed terminology and a shifting emphasis, advocacy of eugenics and its discrimination against poor and mentally retarded persons still persists today. (MC)

  2. Designing a brave new world: eugenics, politics, and fiction.

    Science.gov (United States)

    Woiak, Joanne

    2007-01-01

    Aldous Huxley composed Brave New World in the context of the Depression and the eugenics movement in Britain. Today his novel is best known as satirical and predictive, but an additional interpretation emerges from Huxley's nonfiction writings in which the liberal hurmanist expressed some surprising opinions about eugenics, citizenship, and meritocracy. He felt that his role as an artist and public intellectual was to formulate an evolving outlook on urgent social, scientific, and moral issues. His brave new world can therefore be understood as a serious design for social reform, as well as a commentary about the social uses of scientific knowledge.

  3. American eugenics

    Directory of Open Access Journals (Sweden)

    Darko Polsek

    2002-12-01

    Full Text Available The article describes a troubled history of eugenics in the US, from its beginnings at the end of the 19th century, through the whole of the 20th. It is a part of a larger historical study on eugenics. It focuses on Davenport, Laughlin, Estabrook and the Eugenic Record Office, on the early racist eugenicists like Grant and Ross, and on sterilization legislation in the twenties and thirties. The intention however was to put the historical debate into a contemporary context, or at least to show that some eugenic ideas have lived long after everybody thought they were dead. There are some hints and quotations that show it might still be possible to misuse sterilisation in the US today.

  4. A review of the diversity and evolution of photonic structures in butterflies, incorporating the work of John Huxley (The Natural History Museum, London from 1961 to 1990).

    Science.gov (United States)

    Ingram, A L; Parker, A R

    2008-07-27

    The photonic structures of butterfly wings are among the most anatomically diverse of all those in nature, giving rise to an unrivalled display of structural colours. These have recently become the focus of research by workers in a variety of disciplines, stimulated by their potential applications to technology ('biomimetics'). This interest, together with the discovery of unpublished electron micrographs taken by the late Dr John Huxley (Natural History Museum, London), prompted this review of butterfly photonics in general. The current work provides a synopsis of the literature to date, covering the diversity and evolution of these optical structures and incorporating Huxley's work, which represents an important biomimetic and evolutionary database on its own. This review deals with butterfly photonic devices according to the parts of the butterfly scales on which they occur. In this way, the information is ripe for evolutionary study.

  5. [Eugenics, an element of the literary plots of dystopia].

    Science.gov (United States)

    Baum, Ewa; Musielak, Michał

    2007-01-01

    The work presents the ideas and assumptions of eugenics, a social philosophy established in 1883 by Francis Galton, which affected the social policies of numerous European countries in the first half of the 20th century. The work shows the effect of eugenics on the literary standards of European prose in the previous century. Two outstanding dystopian novels of the 20th century, The Brave New World by Aldous Huxley and 1984 by George Orwell, situate eugenics as a permanent element of the literary plot of dystopia. Apart from the typical features of this type of novel, for example: personal narration with a trace of irony, a totalitarian state and Newspeak, eugenics is an important element of the literary plot with is aim to exclude and marginalise certain social groups. Eugenics is also one of the main social ideas criticised by both the writers.

  6. Evangelizing Eugenics: A Brief Historiography of Popular and Formal American Eugenics Education (1908-1948)

    Science.gov (United States)

    Kohlman, Michael J.

    2012-01-01

    This article examines the history of the American Eugenics movement's penetration into the formal and popular educational milieu during the first half of the 20th Century, and includes a review of some recent scholarly research on eugenic themes in education and popular culture. Apologists have dismissed the American Eugenics movement as a…

  7. ["Baur-Fischer-Lenz" in 1921-1940 critical book reviews: a quantitative study of contemporary reception of racial eugenics theories].

    Science.gov (United States)

    Fangerau, Heiner

    2003-01-01

    In 1921 the distinguished scientists Erwin Baur, Eugen Fischer and Fritz Lenz published the book "Menschliche Erblichkeitslehre und Rassenhygiene" in two volumes. Until 1941 their work went through 5 editions and became the standard textbook on human heredity and racial hygiene (eugenics) in Germany. Between 1921 and 1941 Baur's, Fischer's and Lenz's book was reviewed in many German and foreign scientific and popular journals. 325 of these reviews have been systematically analysed. They paint a representative picture of the book's contemporary reception. The analysis of the reviews helps to quantify the acceptance of the book among the German scientific community and shows how the reviewers created the image of the book as a standard work. Furthermore, the analysis elucidates the style of thinking that was prevalent among the reviewers.

  8. Perspectives: Eugenics and Sterilization in the Heartland.

    Science.gov (United States)

    Wehmeyer, Michael L.

    2003-01-01

    Noting the Governor of Virginia's recent apology for his state's participation in eugenics, this article reviews the history of the sterilization of people with epilepsy and mental retardation in several states, and the importance of the Buck v. Bell (1927) Supreme Court decision in the promotion of eugenics. (Contains references.) (CR)

  9. Aldous Huxley: a beginner's guide

    OpenAIRE

    O'Hara, Kieron

    2012-01-01

    Author of Brave New World and The Doors of Perception, and inventor of the term 'psychedelic', Aldous Huxley was a global trend-setter ahead of his time. Charting his transformation from society satirist to Californian guru-mystic, Aldous Huxley: A Beginner's Guide shows how his ideas evolved and why his writing is still vitally relevant today - from detailing the lures of consumerism to exploring individual responsibility in a globalised world. With biographical notes on Huxley's extraordina...

  10. The Hodgkin-Huxley heritage: from channels to circuits.

    Science.gov (United States)

    Catterall, William A; Raman, Indira M; Robinson, Hugh P C; Sejnowski, Terrence J; Paulsen, Ole

    2012-10-10

    The Hodgkin-Huxley studies of the action potential, published 60 years ago, are a central pillar of modern neuroscience research, ranging from molecular investigations of the structural basis of ion channel function to the computational implications at circuit level. In this Symposium Review, we aim to demonstrate the ongoing impact of Hodgkin's and Huxley's ideas. The Hodgkin-Huxley model established a framework in which to describe the structural and functional properties of ion channels, including the mechanisms of ion permeation, selectivity, and gating. At a cellular level, the model is used to understand the conditions that control both the rate and timing of action potentials, essential for neural encoding of information. Finally, the Hodgkin-Huxley formalism is central to computational neuroscience to understand both neuronal integration and circuit level information processing, and how these mechanisms might have evolved to minimize energy cost.

  11. [Sterilization and eugenics].

    Science.gov (United States)

    Shasha, Shaul M

    2011-04-01

    The term "eugenics" was coined by Francis Galton in 1883 and was defined as the science of the improvement of the human race by better breeding. "Positive eugenics" referred to methods of encouraging the "most fit" to reproduce more often, while "negative eugenics" was related to ways of discouraging or preventing the "less fit" from reproducing by birth control and sterilization. Many western countries adopted eugenics programs including Britain, Canada, Norway, Australia, Switzerland and others. In Sweden more then 62,000 "unfits" were forcibly sterilized. Many states in the U.S.A. had adopted marriage laws with eugenics criteria including forced sterilization. Approximately 64,000 individuals were sterilized. Eugenics considerations also lay behind the adoption of the Immigration Restriction Act of 1924. The Largest plan on eugenics was adopted by the Nazi regime in Germany. Hundreds of thousands of people, who were viewed as being "unfit", were forcibly sterilized by different methods: Surgical sterilization or castration with severe complications and high mortality rates. X-ray irradiation. The method was suggested by Brack, and tested by Schuman using prisoners in Block No. 10 in Auschwitz and Birkenau. Experiments were also performed by Brack on prisoners using the "window method". "Klauberg method"--injection of irritating materials into the uterus. Experiments were conducted using the plant Caladium Seguinum which was believed to have sterilization and castration properties.

  12. Back to the future: eugenics--a bibliographic essay.

    Science.gov (United States)

    Cullen, David

    2007-01-01

    The following essay is a review of the literature about the American eugenics movement produced by scholars over the last fifty years. The essay provides an explanation for today's renewed interest in the subject and for why the science of eugenics remains relevant to contemporary society. The essay examines the catalyst to re-examine the eugenics movement, the influence of Darwinian thought upon its development, the political and institutional support for its growth, the relationship between eugenics, sterilization, and sex, and how the twentieth-century promises of the science of better breeding was a precursor to the twenty-first-century promise of genetic engineering.

  13. Evolution and Education: Lessons from Thomas Huxley

    Science.gov (United States)

    Lyons, Sherrie Lynne

    2010-01-01

    Thomas Huxley more than anyone else was responsible for disseminating Darwin's theory in the western world and maintained that investigating the history of life should be regarded as a purely scientific question free of theological speculation. The content and rhetorical strategy of Huxley's defense of evolution is analyzed. Huxley argued that the…

  14. Filming eugenics: teaching the history of eugenics through film.

    Science.gov (United States)

    Ooten, Melissa; Trembanis, Sarah

    2007-01-01

    In teaching eugenics to undergraduate students and general public audiences, film should he considered as a provocative and fruitful medium that can generate important discussions about the intersections among eugenics, gender, class, race, and sexuality. This paper considers the use of two films, A Bill of Divorcement and The Lynchburg Story, as pedagogical tools for the history of eugenics. The authors provide background information on the films and suggestions for using the films to foster an active engagement with the historical eugenics movement.

  15. Medical Genetics Is Not Eugenics

    Science.gov (United States)

    Cowan, Ruth Schwartz

    2008-01-01

    The connection that critics make between medical genetics and eugenics is historically fallacious. Activists on the political right are as mistaken as activists on the political left: Genetic screening was not eugenics in the past, is not eugenics in the present, and, unless its technological systems become radically transformed, will not be…

  16. Anton's syndrome and eugenics

    DEFF Research Database (Denmark)

    Kondziella, Daniel; Frahm-Falkenberg, Siska

    2011-01-01

    to the clinical neurosciences, including pioneering work in neurosurgery, neuropsychology, and child psychiatry. However, it has not been recognized in the English literature that Anton was also a dedicated advocate of eugenics and racial hygiene. This paper provides a case of Anton's syndrome and puts the works...

  17. [Eugenics: morality or pragmatism].

    Science.gov (United States)

    Gómez Fröde, Carina

    2013-01-01

    The subject of eugenics is as old as humanity itself, but since World War II it has been related almost automatically with the policies and practices implemented by the National Socialist regime. This happened despite the fact that these despicable practices were inspired by legislation in place in the United Sates since the 19th century and which, in some cases, were modified until the 1970's. Today, some state governments are still paying compensation to victims of these policies.

  18. [Eugenics: progress or backward movement?].

    Science.gov (United States)

    González de Cancino, Emilssen

    2007-01-01

    Throughout this article there is a critical analysis of how genetics presents a dilemma for "human progress". So much so, that the legal world aims to create unequivocal norms and guarantees in relation with eugenics in order to avoid attempting against human dignity. The document makes the reader reflect on the ethical problems that eugenics can entail.

  19. Down syndrome: coercion and eugenics.

    Science.gov (United States)

    McCabe, Linda L; McCabe, Edward R B

    2011-08-01

    Experts agree that coercion by insurance companies or governmental authorities to limit reproductive choice constitutes a eugenic practice. We discuss discrimination against families of children with Down syndrome who chose not to have prenatal testing or chose to continue a pregnancy after a prenatal diagnosis. We argue that this discrimination represents economic and social coercion to limit reproductive choice, and we present examples of governmental rhetoric and policies condoning eugenics and commercial policies meeting criteria established by experts for eugenics. Our purpose is to sensitize the clinical genetics community to these issues as we attempt to provide the most neutral nondirective prenatal genetic counseling we can, and as we provide postnatal care and counseling to children with Down syndrome and their families. We are concerned that if eugenic policies and practices targeting individuals with Down syndrome and their families are tolerated by clinical geneticists and the broader citizenry, then we increase the probability of eugenics directed toward other individuals and communities.

  20. Schizophrenia, evolution and the borders of biology: on Huxley et al.'s 1964 paper in Nature.

    Science.gov (United States)

    De Bont, Raf

    2010-06-01

    In October 1964, Julian Huxley, Ernst Mayr, Humphrey Osmond and Abram Hoffer co-published a controversial paper in Nature, in which they tried to explain the persistence of schizophrenia from an evolutionary perspective. This article will elucidate how the reputed authors composed this paper to make it a strong argument for biological psychiatry. Through a close reading of their correspondence, it will furthermore clarify the elements which remained unspoken in the paper, but which were elementary in its genesis. The first was the dominance of psychoanalytical theory in (American) psychiatry--a dominance which the authors wanted to break. The second was the ongoing discussion on the boundaries of biological determinism and the desirability of a new kind of eugenics. As such, the Huxley et al. paper can be used to study the central issues of psychiatry in a pivotal era of its history.

  1. Population Encoding With Hodgkin-Huxley Neurons.

    Science.gov (United States)

    Lazar, Aurel A

    2010-02-01

    The recovery of (weak) stimuli encoded with a population of Hodgkin-Huxley neurons is investigated. In the absence of a stimulus, the Hodgkin-Huxley neurons are assumed to be tonically spiking. The methodology employed calls for 1) finding an input-output (I/O) equivalent description of the Hodgkin-Huxley neuron and 2) devising a recovery algorithm for stimuli encoded with the I/O equivalent neuron(s). A Hodgkin-Huxley neuron with multiplicative coupling is I/O equivalent with an Integrate-and-Fire neuron with a variable threshold sequence. For bandlimited stimuli a perfect recovery of the stimulus can be achieved provided that a Nyquist-type rate condition is satisfied. A Hodgkin-Huxley neuron with additive coupling and deterministic conductances is first-order I/O equivalent with a Project-Integrate-and-Fire neuron that integrates a projection of the stimulus on the phase response curve. The stimulus recovery is formulated as a spline interpolation problem in the space of finite length bounded energy signals. A Hodgkin-Huxley neuron with additive coupling and stochastic conductances is shown to be first-order I/O equivalent with a Project-Integrate-and-Fire neuron with random thresholds. For stimuli modeled as elements of Sobolev spaces the reconstruction algorithm minimizes a regularized quadratic optimality criterion. Finally, all previous recovery results of stimuli encoded with Hodgkin-Huxley neurons with multiplicative and additive coupling, and deterministic and stochastic conductances are extended to stimuli encoded with a population of Hodgkin-Huxley neurons.

  2. [R. Goldschmidt and J. Huxley: creative parallelisms].

    Science.gov (United States)

    Golubovskiĭ, M D; Gall, Ia M

    2003-01-01

    The comparative analysis of scientific heritage of Richard Goldschmidt and Julian Huxley shows convincingly the resemblance of these two scientists' views over the core problems of evolutionary theory, genetics and development biology. They both contributed to developing a triad "genetics--development--evolution". The problem of a relative growth of animals was the central point in both Goldschmidt's and Huxley's works. Huxley developed a formula of the allometric growth (law of constant differential growth) while Goldschmidt was the first to draw up the broad interpretation of the consequences of that phenomenon. Both scientists belonged to initiators of development genetics and used the "non-morganian" genetics in their efforts of solving problems of macroevolution. Goldschmidt tended toward an idea of an important role of macromutation in the process of macroevolution, though Huxley adhered to more moderate views. But at the same time the concept of preadaptive mutations proposed by Huxley was close to Goldschmidt's idea of macromutants. It is shown that both scientists analyzed profoundly the changes in early stages of embryogenesis in respect to macroevolution. It is not likely to be reasonable to oppose firmly Goldschmidt's saltationism to the evolutionary synthesis of Huxley. They developed the larger biological problems in a similar way, and undoubtedly their works in the field helped to enrich the development of the views over genetics and evolution. The open-minded analysis of Goldschmidt's and Huxley's concepts leads to creating modern and up-to-date views over the theory of evolution where seemingly incompatible things go together rather well and supplement each other. Evo-Devo rediscovered Goldshmidt's Biology and Huxley's Synthesis.

  3. Human enhancement: The new eugenics.

    Science.gov (United States)

    Vizcarrondo, Felipe E

    2014-08-01

    Supporters of human enhancement through genetic and other reproductive technologies claim that the new liberal eugenics, based on science and individual consent differs from the old eugenics which was unscientific and coercive. Supporters claim it is the parent's moral obligation to produce the best children possible. At this time, a defective gene that is identified in an unborn child cannot be repaired. To prevent the manifestation of the undesirable trait the unborn child is destroyed. The arguments in support of human enhancement are based on an ethic of consequence that could allow for nearly any means as long as the desired end is reached. Medical enhancement may affect the parent-child family unit; the parents' love for the child may be conditioned on the expected results. The new eugenics, although based on science, continues to pursue the same goal as the old eugenics, the development of a superior individual and the elimination of those considered inferior.

  4. Resistance in School and Society: Public and Pedagogical Debates about Eugenics, 1900-1947.

    Science.gov (United States)

    Selden, Steven

    1988-01-01

    This article reviews positions of scientists, educators and publicists who resisted eugenics and determinism. The nature nurture controversy is discussed, as well as the impact of eugenics on American classrooms. Specific attention is given to four resisters: Dewey, Bagley, Jennings, and Lippmann. (IAH)

  5. Reflections on the Historiography of American Eugenics: Trends, Fractures, Tensions.

    Science.gov (United States)

    Paul, Diane B

    2016-12-01

    By the 1950s, eugenics had lost its scientific status; it now belonged to the context rather than to the content of science. Interest in the subject was also at low ebb. But that situation would soon change dramatically. Indeed, in an essay-review published in 1993, Philip Pauly commented that a "eugenics industry" had come to rival the "Darwin industry" in importance, although the former seemed less integrated than the latter. Since then, the pace of publication on eugenics, including American eugenics, has only accelerated, while the field has become even more fractured, moving in multiple and even contradictory directions. This essay explores the trajectory of work on the history of American eugenics since interest in the subject revived in the 1960s, noting trends and also fractures. The latter are seen to result partly from the fact that professional historians no longer own the subject, which has attracted the interest of scholars in several other disciplines as well as scientists, political activists, and journalists, and also from the fact that the history of eugenics has almost always been policy-oriented. Historians' desire to be policy-relevant and at the same time attentive to context, complexity, and contingency has generated tensions at several levels: within individuals, among historians, and between professional historians and others who also engage with the history of eugenics. That these tensions are resolved differently by different authors and even by the same authors at different times helps explain why the fragmentation that Pauly noted is not likely to be overcome anytime soon.

  6. Eugenics and modern biology: critiques of eugenics, 1910-1945.

    Science.gov (United States)

    Allen, Garland E

    2011-05-01

    Eugenics in most western countries in the first four decades of the 20th century was based on the idea that genes control most human phenotypic traits, everything from physical features such as polydactyly and eye colour to physiological conditions such as the A-B-O blood groups to mental and personality traits such as "feeblemindedness," alcoholism and pauperism. In assessing the development of the eugenics movement-its rise and decline between 1900 and 1950-it is important to recognise that its naïve assumptions and often flawed methodologies were openly criticised at the time by scientists and nonscientists alike. This paper will present a brief overview of the critiques launched against eugenicists' claims, particularly criticisms of the American school led by Charles B. Davenport. Davenport's approach to eugenics will be contrasted to his British counterpart, Karl Pearson, founder and first editor of the Annals of Eugenics. It was not the case that nearly everyone in the early 20th century accepted eugenic conclusions as the latest, cutting-edge science. There are lessons from this historical approach for dealing with similar naïve claims about genetics today. © 2011 The Author Annals of Human Genetics © 2011 Blackwell Publishing Ltd/University College London.

  7. The Characteristics of Korea’s Eugenic Movement in the Colonial Period Represented in the Bulletin, Woosaeng

    Directory of Open Access Journals (Sweden)

    SHIN Young-Jeon

    2006-12-01

    Full Text Available Woosaeng, meaning "eugenic" in Korean, was a bulletin published by the Korean Eugenics Association in 1934. With detailed review of the contributors to Woosaeng, its publication background and the contents, the characteristics of Korea's eugenic movement in 1930's and its historical implications of public health are studied. Intellectuals, especially some medical doctors educated abroad, played the pivotal role in publishing Woosaeng and leading the eugenic movement in 1930's. Lee Gabsoo, a medical doctor educated in Germany, is identified as the key person in the whole process. Most of contributors including Lee considered medical science, especially genetics, as the foundation of eugenics and had strong confidence in their belief. A variety of eugenic movements and activities, including enactment of the national eugenic law around the world, was introduced to the Korean society through Woosaeng and it reinforced the eugenic activities in Korea. Although colonial Korea at the time was being heavily imposed with Japan's culture, the eugenic activities were also influenced by Germany and the US through the contributors educated oversea. The overall content and tone of Woosaeng, revealed its 'soft' characteristics, yet it also implied its vulnerability to 'hard' eugenics. Korea's eugenic movement around Woosaeng faces turnover right before 'The Go Fast Imperialism' period. The high class intellectuals tamed by Japanese colonial paradigm in eugenics took the lead and ended up having a significant influence upon the activities around Woosaeng. And even after Koreans' liberation from Japan's annexation, they were able to retain their influence in public health area in the Korean society. In summary, Woosaeng guided us to understand the characteristics of Korea's eugenic movement in 1930's and the historical context of public health in Korea. Moreover, Woosaeng provided a large amount of information about the eugenic movements around the world as well

  8. Brave new world revisited revisited: Huxley's evolving view of behaviorism

    OpenAIRE

    Newman, Bobby

    1992-01-01

    Aldous Huxley's Brave New World has served as a popular and powerful source of antibehavioral sentiment. Several of Huxley's works are examined in order to ascertain his true thoughts regarding behaviorism. Early in his career Huxley failed to appreciate aspects of behavioral theory (e.g., an appreciation of heredity) or the good ends to which it could be employed. Huxley's later works portrayed behaviorism in a much more positive light, and he believed that behavioral science, along with spi...

  9. Eugenics in Education: Apologetics for Oppression

    Science.gov (United States)

    Hartlep, Nicholas D.

    2008-01-01

    For many people an esoteric educational topic is eugenics. This brief text analysis will provide a textual as well as contextual analysis of Dr. Ann Gibson Winfield's book (2007) Eugenics and Education in America: Institutionalized Racism and the Implications of History, Ideology, and Memory. Winfield objectively critiques eugenic apologetics.…

  10. Human Eugenics: Whose Perception of Perfection?

    Science.gov (United States)

    Mehta, Parendi

    2000-01-01

    Provides historical information on the science of eugenics beginning in ancient Greece. Discusses the use of "racial hygiene" by the Nazis' Third Reich and its effect on eugenics. Addresses the pros and cons of eugenics and genetic engineering. Includes an annotated bibliography. (CMK)

  11. Moderate eugenics and human enhancement.

    Science.gov (United States)

    Selgelid, Michael J

    2014-02-01

    Though the reputation of eugenics has been tarnished by history, eugenics per se is not necessarily a bad thing. Many advocate a liberal new eugenics--where individuals are free to choose whether or not to employ genetic technologies for reproductive purposes. Though genetic interventions aimed at the prevention of severe genetic disorders may be morally and socially acceptable, reproductive liberty in the context of enhancement may conflict with equality. Enhancement could also have adverse effects on utility. The enhancement debate requires a shift in focus. What the equality and/or utility costs of enhancement will be is an empirical question. Rather than philosophical speculation, more social science research is needed to address it. Philosophers, meanwhile, should address head-on the question of how to strike a balance between liberty, equality, and utility in cases of conflict (in the context of genetics).

  12. The Real "Toll" of A. G. Bell: Lessons about Eugenics

    Science.gov (United States)

    Greenwald, Brian H.

    2009-01-01

    Historian Brian Greenwald offers a revisionist interpretation of Bell. He reviews Bell's role and influence within the American eugenics movement and shows that Bell had the respect of the most prominent American eugenicists. His intimate knowledge of deafness, from personal experience with his mother and wife and from his studies of deaf people…

  13. Echoes of a Forgotten Past: Eugenics, Testing, and Education Reform.

    Science.gov (United States)

    Stoskopf, Alan

    2002-01-01

    Review of the work of Goddard, Terman, and Thorndike and the role of eugenics and the intelligence quotient in testing points out dangers to be avoided in the current testing climate, such as use of the business model, single-number scores, and tracking. (Contains 42 references.) (SK)

  14. On nonclassical symmetries of generalized Huxley equations

    CERN Document Server

    Ivanova, Nataliya M

    2010-01-01

    Nonclassical symmetries of a class of generalized Huxley equations of form $u_t=u_{xx}+k(x)u^2(1-u)$ are found. More precisely, for the class under consideration we completely classify reduction operators with $\\tau=1$ and give a wide number of examples of equations admitting reduction operators with $\\tau=0$.

  15. "Eugenics talk" and the language of bioethics.

    Science.gov (United States)

    Wilkinson, S

    2008-06-01

    In bioethical discussions of preimplantation genetic diagnosis and prenatal screening, accusations of eugenics are commonplace, as are counter-claims that talk of eugenics is misleading and unhelpful. This paper asks whether "eugenics talk", in this context, is legitimate and useful or something to be avoided. It also looks at the extent to which this linguistic question can be answered without first answering relevant substantive moral questions. Its main conclusion is that the best and most non-partisan argument for avoiding eugenics talk is the Autonomy Argument. According to this, eugenics talk per se is not wrong, but there is something wrong with using its emotive power as a means of circumventing people's critical-rational faculties. The Autonomy Argument does not, however, tell against eugenics talk when such language is used to shock people into critical-rational thought. These conclusions do not depend on unique features of eugenics: similar considerations apply to emotive language throughout bioethics.

  16. Eugenic utopias/dystopias, reprogenetics, and community genetics.

    Science.gov (United States)

    Raz, Aviad E

    2009-05-01

    The impetus for this review is the intriguing realisation that eugenics, viewed as dystopian and authoritarian in most of the 20th century, is in the process of being reinterpreted today--in the context of reproductive genetics--as utopian and liberal. This review offers an analytical framework for mapping the growing literature on this subject in order to provide a summary for both teaching and research in medical sociology. Recent works are subsumed and explored in three areas: historical criticism of the 'old eugenics'; the continuation of this stream in the form of criticism of reprogenetics as a new, 'backdoor' eugenic regime of bio-governmentality--an area which also includes the application of Foucauldian and feminist perspectives; and the recent enthusiasm regarding 'liberal eugenics,' claiming that reprogenetic decisions should be left to individual consumers thus enhancing their options in the health market. The review concludes by discussing and illustrating potential research directions in this field, with a focus on the social and ethical aspects of 'community genetics' and its emerging networks of individuals genetically at risk.

  17. Eugenics Past and Present: Remembering Buck v. Bell.

    Science.gov (United States)

    Berson, Michael J.; Cruz, Barbara

    2001-01-01

    Provides background information about the eugenics movement. Focuses on eugenics in the United States detailing the case, Buck v. Bell, and eugenics in Germany. Explores the present eugenic movement, focusing on "The Bell Curve," China's one child policy, and the use of eugenic sterilizations in the United States and Canada. Includes…

  18. Tunicates: exploring the sea shores and roaming the open ocean. A tribute to Thomas Huxley.

    Science.gov (United States)

    Lemaire, Patrick; Piette, Jacques

    2015-06-01

    This review is a tribute to the remarkable contributions of Thomas Huxley to the biology of tunicates, the likely sister group of vertebrates. In 1851, the great biologist and philosopher published two landmark papers on pelagic tunicates in the Philosophical Transactions of the Royal Society. They were dedicated to the description of the adult anatomy and life cycle of thaliaceans and appendicularians, the pelagic relatives of ascidians. In the first part of this review, we discuss the novel anatomical observations and evolutionary hypotheses made by Huxley, which would have a lasting influence on tunicate biology. We also briefly comment on the more philosophical reflections of Huxley on individuality. In the second part, we stress the originality and relevance of past and future studies of tunicates in the resolution of major biological issues. In particular, we focus on the complex relationship between genotype and phenotype and the phenomenon of developmental system drift. We propose that more than 150 years after Huxley's papers, tunicate embryos are still worth studying in their own right, independently of their evolutionary proximity to vertebrates, as they provide original and crucial insights into the process of animal evolution. Tunicates are still at the forefront of biological research.

  19. Selling eugenics: the case of Sweden.

    Science.gov (United States)

    Bjorkman, Maria; Widmalm, Sven

    2010-12-20

    This paper traces the early (1910s to 1920s) development of Swedish eugenics through a study of the social network that promoted it. The eugenics network consisted mainly of academics from a variety of disciplines, but with medicine and biology dominating; connections with German scientists who would later shape Nazi biopolitics were strong. The paper shows how the network used political lobbying (for example, using contacts with academically accomplished MPs) and various media strategies to gain scientific and political support for their cause, where a major goal was the creation of a eugenics institute (which opened in 1922). It also outlines the eugenic vision of the institute's first director, Herman Lundborg. In effect the network, and in particular Lundborg, promoted the view that politics should be guided by eugenics and by a genetically superior elite. The selling of eugenics in Sweden is an example of the co-production of science and social order.

  20. Unidirectional synchronization of Hodgkin-Huxley neurons

    Energy Technology Data Exchange (ETDEWEB)

    Cornejo-Perez, Octavio [Division de Matematicas Aplicadas y Sistemas, Computacionales, IPICYT, Apdo. Postal 3-74 Tangamanga, 78231 San Luis Potosi (Mexico)]. E-mail: octavio@ipicyt.edu.mx; Femat, Ricardo [Division de Matematicas Aplicadas y Sistemas, Computacionales, IPICYT, Apdo. Postal 3-74 Tangamanga, 78231 San Luis Potosi (Mexico)]. E-mail: rfemat@ipicyt.edu.mx

    2005-07-01

    Synchronization dynamics of two noiseless Hodgkin-Huxley (HH) neurons under the action of feedback control is studied. The spiking patterns of the action potentials evoked by periodic external modulations attain synchronization states under the feedback action. Numerical simulations for the synchronization dynamics of regular-irregular desynchronized spiking sequences are displayed. The results are discussed in context of generalized synchronization. It is also shown that the HH neurons can be synchronized in face of unmeasured states.

  1. The what and where of adding channel noise to the Hodgkin-Huxley equations.

    Science.gov (United States)

    Goldwyn, Joshua H; Shea-Brown, Eric

    2011-11-01

    Conductance-based equations for electrically active cells form one of the most widely studied mathematical frameworks in computational biology. This framework, as expressed through a set of differential equations by Hodgkin and Huxley, synthesizes the impact of ionic currents on a cell's voltage--and the highly nonlinear impact of that voltage back on the currents themselves--into the rapid push and pull of the action potential. Later studies confirmed that these cellular dynamics are orchestrated by individual ion channels, whose conformational changes regulate the conductance of each ionic current. Thus, kinetic equations familiar from physical chemistry are the natural setting for describing conductances; for small-to-moderate numbers of channels, these will predict fluctuations in conductances and stochasticity in the resulting action potentials. At first glance, the kinetic equations provide a far more complex (and higher-dimensional) description than the original Hodgkin-Huxley equations or their counterparts. This has prompted more than a decade of efforts to capture channel fluctuations with noise terms added to the equations of Hodgkin-Huxley type. Many of these approaches, while intuitively appealing, produce quantitative errors when compared to kinetic equations; others, as only very recently demonstrated, are both accurate and relatively simple. We review what works, what doesn't, and why, seeking to build a bridge to well-established results for the deterministic equations of Hodgkin-Huxley type as well as to more modern models of ion channel dynamics. As such, we hope that this review will speed emerging studies of how channel noise modulates electrophysiological dynamics and function. We supply user-friendly MATLAB simulation code of these stochastic versions of the Hodgkin-Huxley equations on the ModelDB website (accession number 138950) and http://www.amath.washington.edu/~etsb/tutorials.html.

  2. Brave new world revisited revisited: Huxley's evolving view of behaviorism.

    Science.gov (United States)

    Newman, B

    1992-01-01

    Aldous Huxley's Brave New World has served as a popular and powerful source of antibehavioral sentiment. Several of Huxley's works are examined in order to ascertain his true thoughts regarding behaviorism. Early in his career Huxley failed to appreciate aspects of behavioral theory (e.g., an appreciation of heredity) or the good ends to which it could be employed. Huxley's later works portrayed behaviorism in a much more positive light, and he believed that behavioral science, along with spiritual enlightenment, might help save humanity from the Brave New World he predicted.

  3. [The dispute over eugenics in interwar Poland].

    Science.gov (United States)

    Kawalec, K

    2000-01-01

    The eugenic problem seems not as well known as it was in the period between the world wars. The word "eugenics" was introduced into the scientific language by the British biologist, Francis Galton at the end of the XIX century. In general, it means the study of the methods of protecting and improving the quality of the human race by selective breeding. Galton's remarks initiated a wider (social and political) movement, which was active in some countries. The eugenic tendency was visible in American immigration policy before the Great War - making it difficult for people suffering from particular diseases to enter the USA. After the war, the eugenic movement became much stronger. In some countries (e.g. Sweden, Norway, Finland, Denmark, Switzerland, Germany, and over half of the states of the USA) some components of the eugenic programme were introduced into legislation. The eugenic movement also appeared in reconstructed Poland. In 1918 it published it own magazine "Zagadnienia Rasy" (Problems of Human Race), later "Eugenika Polska" (Polish Eugenics). This did not imply however, that interest in the eugenic programme was generally very strong. In fact, it was limited by the influence of the Catholic Church. Another significant factor was lost Polish - German hostility. In the late thirties eugenic slogans lost popularity because of their use in Germany racist policy.

  4. Eugenics and Curriculum: 1860-1929.

    Science.gov (United States)

    Selden, Steven

    1978-01-01

    Examines ideas about heredity, racism, and the development of the eugenics movement, which influenced curriculum thinkers in the period of the "naturalistic mind" and progressivism; the eugenics movement's influence upon education for the gifted; and continuing similar attitudes as to the limited effect of environment on individuals…

  5. [Sir Francis Galton: the father of eugenics].

    Science.gov (United States)

    Aubert-Marson, Dominique

    2009-01-01

    Not only was Sir Francis Galton a famous geographer and statistician, he also invented "eugenics" in 1883. Eugenics, defined as the science of improving racial stock, was developed from a new heredity theory, conceived by Galton himself, and from the evolution theory of Charles Darwin, transposed to human society by Herbert Spencer. Galton's eugenics was a program to artificially produce a better human race through regulating marriage and thus procreation. Galton put particular emphasis on "positive eugenics", aimed at encouraging the physically and mentally superior members of the population to choose partners with similar traits. In 1904, he presented his ideas in front of a vast audience of physicians and scientists in London. His widely-publicized lecture served as the starting point for the development of eugenics groups in Europe and the United States during the first half of the 20th century.

  6. Eugenics concept: from Plato to present.

    Science.gov (United States)

    Güvercin, C H; Arda, B

    2008-01-01

    All prospective studies and purposes to improve cure and create a race that would be exempt of various diseases and disabilities are generally defined as eugenic procedures. They aim to create the "perfect" and "higher" human being by eliminating the "unhealthy" prospective persons. All of the supporting actions taken in order to enable the desired properties are called positive eugenic actions; the elimination of undesired properties are defined as negative eugenics. In addition, if such applications and approaches target the public as a whole, they are defined as macro-eugenics. On the other hand, if they only aim at individuals and/or families, they are called micro-eugenics. As generally acknowledged, Galton re-introduced eugenic proposals, but their roots stretch as far back as Plato. Eugenic thoughts and developments were widely accepted in many different countries beginning with the end of the 19th to the first half of the 20th centuries. Initially, the view of negative eugenics that included compulsory sterilizations of handicapped, diseased and "lower" classes, resulted in tens of thousands being exterminated especially in the period of Nazi Germany. In the 1930s, the type of micro positive eugenics movement found a place within the pro-natalist policies of a number of countries. However, it was unsuccessful since the policy was not able to become effective enough and totally disappeared in the 1960s. It was no longer a fashionable movement and left a deep impression on public opinion after the long years of war. However, developments in genetics and its related fields have now enabled eugenic thoughts to reappear under the spotlight and this is creating new moral dilemmas from an ethical perspective.

  7. Propulsion by light: visions of the German pioneer Eugen Saenger

    Science.gov (United States)

    Bohn, Willy L.

    2005-03-01

    Although the laser was not yet invented Eugen Sanger, one of the most prominent German personalities in the early development of hypersonic flight and rocket technology suggested to use photons for the propulsion of spacecrafts in the fifties. In contrast to current schemes which are mostly aimed at laser induced ablation processes, Eugen Sanger started with the idea of using the radiation pressure itself for propulsion purposes. A review of his pioneering work in that area will be supported by numerous historical documents and personal remembrance showing his effort to promote unconventional ideas. The paper also emphasizes how some of the original concepts are being revisited and partly implemented by using today's laser technology.

  8. Christianity and Eugenics: The Place of Religion in the British Eugenics Education Society and the American Eugenics Society, c.1907-1940.

    Science.gov (United States)

    Baker, Graham J

    2014-05-01

    Historians have regularly acknowledged the significance of religious faith to the eugenics movement in Britain and the USA. However, much of this scholarship suggests a polarised relationship of either conflict or consensus. Where Christian believers participated in the eugenics movement this has been represented as an abandonment of 'orthodox' theology, and the impression has been created that eugenics was a secularising force. In contrast, this article explores the impact of religious values on two eugenics organisations: the British Eugenics Education Society, and the American Eugenics Society. It is demonstrated that concerns over religion resulted in both these organisations modifying and tempering the public work that they undertook. This act of concealing and minimising the visibly controversial aspects of eugenics is offered as an addition to the debate over 'mainline' versus 'reform' eugenics.

  9. KRITIK TERHADAP ALIRAN SOCIOLOGICAL JURISPRUDENCE EUGEN EHRLICH

    OpenAIRE

    W.M. Herry Susilowati

    2000-01-01

    Eugen Ehrlich, seorang ahli hukum dan sosiologi dengan teorinya Sociological Jurisprudence, ingin membuktikan bahwa titik berat perkembangan hukum terletak pada masyarakat itu sendiri dengan konsep dasarnya “living law” yang mencerminkan nilai-nilai yang hidup dalam masyarakat (volkgeist). Dan apa yang dimaksud dengan volkgeist itu, Eugen Ehrlich tidak dapat memberikan jawaban secara memuaskan. Mochtar Kusumaatmadja mencoba mencari jalan keluar dengan teorinya yang dikenal dengan Teori Hukum ...

  10. Heuristics for the Hodgkin-Huxley system.

    Science.gov (United States)

    Hoppensteadt, Frank

    2013-09-01

    Hodgkin and Huxley (HH) discovered that voltages control ionic currents in nerve membranes. This led them to describe electrical activity in a neuronal membrane patch in terms of an electronic circuit whose characteristics were determined using empirical data. Due to the complexity of this model, a variety of heuristics, including relaxation oscillator circuits and integrate-and-fire models, have been used to investigate activity in neurons, and these simpler models have been successful in suggesting experiments and explaining observations. Connections between most of the simpler models had not been made clear until recently. Shown here are connections between these heuristics and the full HH model. In particular, we study a new model (Type III circuit): It includes the van der Pol-based models; it can be approximated by a simple integrate-and-fire model; and it creates voltages and currents that correspond, respectively, to the h and V components of the HH system.

  11. Eugenics and Involuntary Sterilization: 1907-2015.

    Science.gov (United States)

    Reilly, Philip R

    2015-01-01

    In England during the late nineteenth century, intellectuals, especially Francis Galton, called for a variety of eugenic policies aimed at ensuring the health of the human species. In the United States, members of the Progressive movement embraced eugenic ideas, especially immigration restriction and sterilization. Indiana enacted the first eugenic sterilization law in 1907, and the US Supreme Court upheld such laws in 1927. State programs targeted institutionalized, mentally disabled women. Beginning in the late 1930s, proponents rationalized involuntary sterilization as protecting vulnerable women from unwanted pregnancy. By World War II, programs in the United States had sterilized approximately 60,000 persons. After the horrific revelations concerning Nazi eugenics (German Hereditary Health Courts approved at least 400,000 sterilization operations in less than a decade), eugenic sterilization programs in the United States declined rapidly. Simplistic eugenic thinking has faded, but coerced sterilization remains widespread, especially in China and India. In many parts of the world, involuntary sterilization is still intermittently used against minority groups.

  12. Singularly perturbed Burger-Huxley equation: Analytical solution ...

    African Journals Online (AJOL)

    user

    Keywords: Burger-Huxley equation, iteration method, analytical solution, ... dynamics, chemical kinetics and mathematical biology (Albowitz and Clarkson, ... numbers, Navier-Stokes flows with large Reynolds numbers, chemical reactor theory, ...

  13. Whistles, bells, and cogs in machines: Thomas Huxley and epiphenomenalism.

    Science.gov (United States)

    Greenwood, John

    2010-01-01

    In this paper I try to shed some historical light upon the doctrine of epiphenomenalism, by focusing on the version of epiphenomenalism championed by Thomas Huxley, which is often treated as a classic statement of the doctrine. I argue that it is doubtful if Huxley held any form of metaphysical epiphenomenalism, and that he held a more limited form of empirical epiphenomenalism with respect to consciousness but not with respect to mentality per se. Contrary to what is conventionally supposed, Huxley's empirical epiphenomenalism with respect to consciousness was not simply based upon the demonstration of the neurophysiological basis of conscious mentality, or derived from the extension of mechanistic and reflexive principles of explanation to encompass all forms of animal and human behavior, but was based upon the demonstration of purposive and coordinated animal and human behavior in the absence of consciousness. Given Huxley's own treatment of mentality, his characterization of animals and humans as "conscious automata" was not well chosen.

  14. Remembrance of Hugh E. Huxley, a founder of our field.

    Science.gov (United States)

    Pollard, Thomas D; Goldman, Yale E

    2013-09-01

    Hugh E. Huxley (1924-2013) carried out structural studies by X-ray fiber diffraction and electron microscopy that established how muscle contracts. Huxley's sliding filament mechanism with an ATPase motor protein taking steps along an actin filament, established the paradigm not only for muscle contraction but also for other motile systems using actin and unconventional myosins, microtubules and dynein and microtubules and kinesin.

  15. Science, Sexuality, and the Novels of Huxley and Houellebecq

    OpenAIRE

    2003-01-01

    In her article "Science, Sexuality, and the Novels of Huxley and Houellebecq," Angela C. Holzer begins with an introduction to recent discourse about contemporary culture by Francis Fukuyama, notably in his book Our Posthuman Future (2001). Next, Holzer introduces twentieth-century literary representations of genetic engineering. Focusing on Huxley's Brave New World (1932) and on Houellebecq's Les Particules élémentaires (1998), Holzer discusses differences in "utopian" literature when linked...

  16. Eugene Paul Wigner's Nobel Prize

    CERN Document Server

    Kim, Y S

    2016-01-01

    In 1963, Eugene Paul Wigner was awarded the Nobel Prize in Physics for his contributions to the theory of the atomic nucleus and the elementary particles, particularly through the discovery and application of fundamental symmetry principles. There are no disputes about this statement. On the other hand, there still is a question of why the statement did not mention Wigner's 1939 paper on the Lorentz group, which was regarded by Wigner and many others as his most important contribution in physics. By many physicists, this paper was regarded as a mathematical exposition having nothing to do with physics. However, it has been more than one half century since 1963, and it is of interest to see what progress has been made toward understanding physical implications of this paper and its historical role in physics. Wigner in his 1963 paper defined the subgroups of the Lorentz group whose transformations do not change the four-momentum of a given particle, and he called them the little groups. Thus, Wigner's little g...

  17. Iowa and Eugene, Oregon, Orthopaedics

    Science.gov (United States)

    Buckwalter, Joseph A

    2003-01-01

    Over the last 50 years, the commitment of orthopaedic surgeons to basic and clinical research and evaluation of treatment outcomes has made possible remarkable improvements in the care of people with injuries and diseases of the limbs and spine. A group of Oregon orthopaedic surgeons has had an important role in these advances, especially in the orthopaedic specialties of sports medicine and hip reconstruction. Since Don Slocum (Iowa Orthopaedic Resident, 1934-1937), started practice in Eugene, Oregon, in 1939, three orthopaedic surgeons, Denny Collis, Craig Mohler and Paul Watson, who received their orthopaedic residency education at the University of Iowa, and three orthopaedic surgeons, Stan James, Tom Wuest and Dan Fitzpatrick, who received their undergraduate, medical school and orthopaedic residency education at the University of Iowa, have joined the group Dr. Slocum founded. These individuals, and their partners, established and have maintained a successful growing practice that serves the people of the Willamette valley, but in addition, they have made important contributions to the advancement of orthopaedics. PMID:14575262

  18. Social imaginaries: the literature of eugenics.

    Science.gov (United States)

    Sinclair, Alison

    2008-06-01

    This paper starts from a premise relating to the act of fictional writing about eugenics and the way it may be understood as the embodiment and enactment of social imaginaries. It proposes that literature (in the sense of fiction) frequently, if not habitually, expresses the underside of what is expressed in public discourse. That is, far from being the implement of state policy or intervention, it acts in counterpoint to the state, constituting a type of social fantasy in that it explores through the realm of the imagination what might happen. It becomes the arena for contestation, exploration, and nuancing as it essays how ideas from public, 'real' life, might transform when acted out. The paper considers two sorts of literary case. First it looks at that of 'naïve' literature, harnessed unashamedly to a specific sociological discourse of eugenics. Then, using primarily Ibsen, it considers a subset, the case of literature that does not set out to be explicitly in the service of the cause of eugenics, but is appropriated and disseminated from a platform of eugenics. Lastly, taking the example of Unamuno's Amor y pedagogía (1902) the paper considers literature that exists in a quite different sphere of public awareness. It shows awareness of the arguments and precepts of eugenics and related beliefs and practices, but acts as a transitional space (in the terms of Winnicott) to enable such ideas to be entertained and thought about, without a requirement of acceptance or belief.

  19. The public and private history of eugenics: an introduction.

    Science.gov (United States)

    Burke, Chloe S; Castaneda, Christopher J

    2007-01-01

    Inspired by our experience addressing the legacy of eugenics at California State University, Sacramento, this special issue presents an array of articles representative of diverse approaches to the historical investigation of eugenics. This article provides an introduction to the history of eugenics and explores the ways in which public history is particularly well suited to shape the historical memory of eugenics and encourage dialogue about contemporary biotechnologies.

  20. Spike neural models (part I: The Hodgkin-Huxley model

    Directory of Open Access Journals (Sweden)

    Johnson, Melissa G.

    2017-05-01

    Full Text Available Artificial neural networks, or ANNs, have grown a lot since their inception back in the 1940s. But no matter the changes, one of the most important components of neural networks is still the node, which represents the neuron. Within spiking neural networks, the node is especially important because it contains the functions and properties of neurons that are necessary for their network. One important aspect of neurons is the ionic flow which produces action potentials, or spikes. Forces of diffusion and electrostatic pressure work together with the physical properties of the cell to move ions around changing the cell membrane potential which ultimately produces the action potential. This tutorial reviews the Hodkgin-Huxley model and shows how it simulates the ionic flow of the giant squid axon via four differential equations. The model is implemented in Matlab using Euler's Method to approximate the differential equations. By using Euler's method, an extra parameter is created, the time step. This new parameter needs to be carefully considered or the results of the node may be impaired.

  1. Eugenics and the Social Construction of Merit, Race, and Disability.

    Science.gov (United States)

    Selden, Steven

    2000-01-01

    Contends that eugenics is an example of normalization. Outlines an aspect of this process by analyzing: (1) the popular eugenic knowledge exhibited at U.S. state fairs; and (2) the mainstream eugenic knowledge found in the work of Leta S. Hollingworth who was an early leader in gifted education. (CMK)

  2. Eugenics in the community: gendered professions and eugenic sterilization in Alberta, 1928-1972.

    Science.gov (United States)

    Samson, Amy

    2014-01-01

    Scholarship on Alberta's Sexual Sterilization Act (1928-1972) has focused on the high-level politics behind the legislation, its main administrative body, the Eugenics Board, and its legal legacy, overlooking the largely female-dominated professions that were responsible for operating the program outside of the provincial mental health institutions. This paper investigates the relationship between eugenics and the professions of teaching, public health nursing, and social work. It argues that the Canadian mental hygiene and eugenics movements, which were fundamentally connected, provided these professions with an opportunity to maintain and extend their professional authority.

  3. Project Coast: eugenics in apartheid South Africa.

    Science.gov (United States)

    Singh, Jerome Amir

    2008-03-01

    It is a decade since the exposure of Project Coast, apartheid South Africa's covert chemical and biological warfare program. In that time, attention has been focused on several aspects of the program, particularly the production of narcotics and poisons for use against anti-apartheid activists and the proliferation of both chemical and biological weapons. The eugenic dimension of Project Coast has, by contrast, received scant attention. It is time to revisit the testimony that brought the suggestion of eugenic motives to light, reflect on some of the Truth and Reconciliation Commission's findings and search for lessons that can be taken from this troubled chapter in South Africa's history.

  4. Professionalization and the Null Curriculum: The Case of the Popular Eugenics Movement and American Educational Studies.

    Science.gov (United States)

    Selden, Steven

    1987-01-01

    Presents an essay review of three recent books on eugenics, a once popular quasiscientific and politically conservative social movement devoted to the improvement of humankind through programs of selective breeding and marriage restriction. States that educators must study and come to grips with the meaning of this movement in order to appreciate…

  5. Thoughts on the Changing Meaning of Disability: New Eugenics or New Wholeness?

    Science.gov (United States)

    Smith, J. David

    1999-01-01

    Reviews the impact of eugenics on people with disabilities and the danger that they will be further devalued in a world of increasing genetic manipulation. Margaret Mead's concept of providing opportunities for all people to learn how to participate wholly in society and the need for an ethical revolution are discussed. (CR)

  6. Eugene Dening: Young Artist from Alberta

    Science.gov (United States)

    Sanders, James H.

    2009-01-01

    Eugene Dening, an emerging artist in Canada, recently earned his Bachelors degree at the Calvin College (Grand Rapids, MI). This essay on his artwork explores the value of art making to LGBT youth, those gay and lesbian artists who have influenced their work, and those queer and critical readings practices that one can apply to arts' viewing.…

  7. Eugene Dening: Young Artist from Alberta

    Science.gov (United States)

    Sanders, James H.

    2009-01-01

    Eugene Dening, an emerging artist in Canada, recently earned his Bachelors degree at the Calvin College (Grand Rapids, MI). This essay on his artwork explores the value of art making to LGBT youth, those gay and lesbian artists who have influenced their work, and those queer and critical readings practices that one can apply to arts' viewing.…

  8. Advertising eugenics: Charles M. Goethe's campaign to improve the race.

    Science.gov (United States)

    Schoenl, William; Peck, Danielle

    2010-06-01

    Over the last several decades historians have shown that the eugenics movement appealed to an extraordinarily wide constituency. Far from being the brainchild of the members of any one particular political ideology, eugenics made sense to a diverse range of Americans and was promoted by professionals ranging from geneticists and physicians to politicians and economists.(1) Seduced by promises of permanent fixes to national problems, and attracted to the idea of a scientifically legitimate form of social activism, eugenics quickly grew in popularity during the first decades of the twentieth century. Charles M. Goethe, the land developer, entrepreneur, conservationist and skilled advertiser who founded the Eugenics Society of Northern California, exemplifies the broad appeal of the eugenics movement. Goethe played an active role within the American eugenics movement at its peak in the 1920s. The last president of the Eugenics Research Association,(2) he also campaigned hard against Mexican immigration to the US and he continued open support for the Nazi regime's eugenic practices into the later 1930s.(3) This article examines Goethe's eugenic vision and, drawing on his correspondence with the leading geneticist Charles Davenport, explores the relationship between academic and non-academic advocates of eugenics in America. Published by Elsevier Ltd.

  9. Dartington: A Principal Source of Inspiration behind Aldous Huxley's "Island".

    Science.gov (United States)

    Parsons, David

    1987-01-01

    Describes Dartington Hall School in Devon, England, which between the 1920s and 1970s implemented an educational system combining traditional Hindu religious philosophy and ideals of living and Western scientific knowledge and work experience. Considers ways Dartington educationally and socially resembled Aldous Huxley's utopia in…

  10. Huxley College of Environmental Studies, Western Washington University.

    Science.gov (United States)

    Miles, John C.

    1987-01-01

    Describes the programs of Huxley College (Washington) which were designed to provide an environmental studies thread through all of its academic endeavors. Addresses the development of the curriculum of both the undergraduate and graduate levels. Discusses its research focal points and its prospects for the future. (TW)

  11. [Eugen Bleuler and Carl Gustav Jung's habilitation].

    Science.gov (United States)

    Wilhelm, H R

    1996-01-01

    Eugen Bleuler's letter of recommendation for Carl Gustav Jung's appointment as a lecturer In January 1905, Eugen Bleuler (1857-1939) wrote a letter of recommendation to the Medical Faculty of the University of Zurich, urging them to accept the application of Carl Gustav Jung (1875-1961) as a lecturer there. Bleuler's letter mentions the contribution to Jung's writing made by Franz Riklin (1878-1938), although he does not define it precisely. It is safe to say that, judging from the way in which Bleuler expresses his opinions in this letter, this may be regarded at the very least as an early sign of his receptiveness to the psychoanalytical ideas of the time.

  12. A Canadian paradox: Tommy Douglas and eugenics.

    Science.gov (United States)

    Shevell, Michael

    2012-01-01

    Tommy Douglas is an icon of Canadian 20th Century political history and is considered by many as the "Father" of Medicare, a key component of our national identity. Throughout his career, he was associated at both the provincial and federal levels with progressive causes concerning disadvantaged populations. In his sociology Master's thesis written in the early 1930's, Douglas endorsed eugenic oriented solutions such as segregation and sterilization to address what was perceived to be an endemic and biologically determined problem. At first glance, this endorsement of eugenics appears to be paradoxical, but careful analysis revealed that this paradox has multiple roots in religion, political belief, historical exposure and our own desire to view our collective history in a favourable light.

  13. Better science and better race? Social Darwinism and Chinese eugenics.

    Science.gov (United States)

    Chung, Yuehtsen Juliette

    2014-12-01

    This essay explores the variegated roles played by racial, eugenic, and Social Darwinist discourse in China over roughly the last century. Using Japan as a parallel for comparison, it analyzes the introduction of the term "eugenics" into Japanese and Chinese. It then locates the deployment of eugenics and Social Darwinism as counterimperial discourse in East Asia. It offers a brief history of eugenics thinking in China across the twentieth century, focusing on the Chinese eugenicist Pan Guangdan, who used race as a category of analysis yet without any sense of hierarchy. He was critically aware of the scientific basis of eugenics and helped craft the study of eugenics in China, from biology to sociology, from economics to ethnology.

  14. Eugen Bleuler 150: Bleuler's reception of Freud.

    Science.gov (United States)

    Dalzell, Thomas G

    2007-12-01

    On the 150th anniversary of Eugen Bleuler's birth, this article examines his reception of Sigmund Freud and his use of Freudian theory to understand the symptoms of schizophrenia. In addition, in contrast to earlier interpretations of Bleuler's relationship with Freud in terms of an eventual personal and theoretical incompatibility, the article demonstrates that, although Bleuler did distance himself from the psychoanalytic movement, he remained consistent in his views on Freud's theories.

  15. KRITIK TERHADAP ALIRAN SOCIOLOGICAL JURISPRUDENCE EUGEN EHRLICH

    Directory of Open Access Journals (Sweden)

    W.M. Herry Susilowati

    2000-01-01

    Full Text Available Eugen Ehrlich, seorang ahli hukum dan sosiologi dengan teorinya Sociological Jurisprudence, ingin membuktikan bahwa titik berat perkembangan hukum terletak pada masyarakat itu sendiri dengan konsep dasarnya “living law” yang mencerminkan nilai-nilai yang hidup dalam masyarakat (volkgeist. Dan apa yang dimaksud dengan volkgeist itu, Eugen Ehrlich tidak dapat memberikan jawaban secara memuaskan. Mochtar Kusumaatmadja mencoba mencari jalan keluar dengan teorinya yang dikenal dengan Teori Hukum Pembangunan, yaitu bahwa “nilai-nilai yang hidup di masyarakat” berkaitan dengan “perasaan keadilan masyarakat” atau “kesadaran hukum masyarakat”. Di samping itu, teori Eugen Ehrlich (Teori Sociological Jurisprudence terdapat 3 (tiga kelemahan pokok yaitu: pertama, ajaran tersebut tidak dapat memberikan kriteria yang jelas yang membedakan norma hukum dari norma sosial yang lain; kedua, Ehrlich meragukan pisisi adat kebiasaan sebagai “sumber” hukum dan adat kebiasaan sebagai suatu bentuk hukum; ketiga, Ehrlich menolak mengikuti logika perbedaan antara norma-norma hukum negara yang khas dan norma-norma hukum dimana negara hanya memberi sanksi pada fakta sosial.

  16. Obituary: Eugene Richard Tomer, 1932-2007

    Science.gov (United States)

    Dunkl, Charles F.

    2009-01-01

    Dr. Eugene R. Tomer passed away on 2 July 2007 at his home in San Francisco, California. The cause of death was cancer. Tomer was a consulting applied mathematician with a wide range of interests in dynamical astronomy, electromagnetic theory for use in communications, and computational methods of applied mathematics. He was a member of AAS, and the Society for Applied and Industrial Mathematics [SIAM]. With K. H. Prendergast, he co-wrote the influential paper "Self-consistent Models of Elliptical Galaxies," published in the Astronomical Journal 75 (1970), 674-679. This paper has been cited over eighty times. Tomer was born on 13 June 1932. He earned the Ph.D. in Mathematics at the University of California-Berkeley in 1978 (title of dissertation: On the C*-algebra of the Hermite Operator). In 1996 he and A. F. Peterson wrote "Meeting the Challenges Presented by Computational Electromagnetics," a publication of the Naval Postgraduate School at Monterey, California. This writer met Eugene at the 1992 Annual SIAM meeting in Los Angeles in connection with the Activity Group on Orthogonal Polynomials and Special Functions, which the writer chaired at the time. Eugene volunteered to edit the Newsletter of the group, which he did from July 1992 to July 1995. Thanks to his skills and efforts, the Newsletter became a carefully edited, professional publication. Eugene not only organized a Problems Column, attracting questions in pure and applied mathematics, but he also designed the logo for the group. He gave much time and effort to this service, in an era when copy had to be physically assembled and mailed to SIAM Headquarters. Eventually he felt he had done what he could for the Activity Group. He told me that he hoped the Group would get seriously involved with applications such as in astronomy, physics, and sciences that use special function solutions of differential equations. During Tomer's editorship, we communicated mostly by e-mail, our homes being far apart. He

  17. Statistical mechanics of the Huxley-Simmons model.

    Science.gov (United States)

    Caruel, M; Truskinovsky, L

    2016-06-01

    The chemomechanical model of Huxley and Simmons (HS) [A. F. Huxley and R. M. Simmons, Nature 233, 533 (1971)NATUAS0028-083610.1038/233533a0] provides a paradigmatic description of mechanically induced collective conformational changes relevant in a variety of biological contexts, from muscles power stroke and hair cell gating to integrin binding and hairpin unzipping. We develop a statistical mechanical perspective on the HS model by exploiting a formal analogy with a paramagnetic Ising model. We first study the equilibrium HS model with a finite number of elements and compute explicitly its mechanical and thermal properties. To model kinetics, we derive a master equation and solve it for several loading protocols. The developed formalism is applicable to a broad range of allosteric systems with mean-field interactions.

  18. Statistical mechanics of the Huxley-Simmons model

    CERN Document Server

    Caruel, M

    2016-01-01

    The chemomechanical model of Huxley and Simmons (HS) [A. F. Huxley and R. M. Simmons, Nature 233, 533 (1971)] provides a paradigmatic description of mechanically induced collective conformational changes relevant in a variety of biological contexts, from muscles power-stroke and hair cell gating to integrin binding and hairpin unzipping. We develop a statistical mechanical perspective on the HS model by exploiting a formal analogy with a paramagnetic Ising model. We first study the equilibrium HS model with a finite number of elements and compute explicitly its mechanical and thermal properties. To model kinetics, we derive a master equation and solve it for several loading protocols. The developed formalism is applicable to a broad range of allosteric systems with mean-field interactions.

  19. Statistical mechanics of the Huxley-Simmons model

    Science.gov (United States)

    Caruel, M.; Truskinovsky, L.

    2016-06-01

    The chemomechanical model of Huxley and Simmons (HS) [A. F. Huxley and R. M. Simmons, Nature 233, 533 (1971), 10.1038/233533a0] provides a paradigmatic description of mechanically induced collective conformational changes relevant in a variety of biological contexts, from muscles power stroke and hair cell gating to integrin binding and hairpin unzipping. We develop a statistical mechanical perspective on the HS model by exploiting a formal analogy with a paramagnetic Ising model. We first study the equilibrium HS model with a finite number of elements and compute explicitly its mechanical and thermal properties. To model kinetics, we derive a master equation and solve it for several loading protocols. The developed formalism is applicable to a broad range of allosteric systems with mean-field interactions.

  20. An efficient method for solving fractional Hodgkin–Huxley model

    Energy Technology Data Exchange (ETDEWEB)

    Nagy, A.M., E-mail: abdelhameed_nagy@yahoo.com [Department of Mathematics, Faculty of Science, Benha University, 13518 Benha (Egypt); Sweilam, N.H., E-mail: n_sweilam@yahoo.com [Department of Mathematics, Faculty of Science, Cairo University, 12613 Giza (Egypt)

    2014-06-13

    In this paper, we present an accurate numerical method for solving fractional Hodgkin–Huxley model. A non-standard finite difference method (NSFDM) is implemented to study the dynamic behaviors of the proposed model. The Grünwald–Letinkov definition is used to approximate the fractional derivatives. Numerical results are presented graphically reveal that NSFDM is easy to implement, effective and convenient for solving the proposed model. - Highlights: • An accurate numerical method for solving fractional Hodgkin–Huxley model is given. • Non-standard finite difference method (NSFDM) is implemented to the proposed model. • NSFDM can solve differential equations involving derivatives of non-integer order. • NDFDM is very powerful and efficient technique for solving the proposed model.

  1. Parameter estimation of the Huxley cross-bridge muscle model in humans.

    Science.gov (United States)

    Vardy, Alistair N; de Vlugt, Erwin; van der Helm, Frans C T

    2012-01-01

    The Huxley model has the potential to provide more accurate muscle dynamics while affording a physiological interpretation at cross-bridge level. By perturbing the wrist at different velocities and initial force levels, reliable Huxley model parameters were estimated in humans in vivo using a Huxley muscle-tendon complex. We conclude that these estimates may be used to investigate and monitor changes in microscopic elements of muscle functioning from experiments at joint level.

  2. Chiral Solutions to Generalized Burgers and Burgers-Huxley Equations

    CERN Document Server

    Bazeia, D

    1998-01-01

    We investigate generalizations of the Burgers and Burgers-Huxley equations. The investigations we offer focus attention mainly on presenting explict analytical solutions by means of relating these generalized equations to relativistic 1+1 dimensional systems of scalar fields where topological solutions are known to play a role. Emphasis is given on chiral solutions, that is, on the possibility of finding solutions that travel with velocities determined in terms of the parameters that identify the generalized equation, with a definite sign.

  3. An efficient method for solving fractional Hodgkin-Huxley model

    Science.gov (United States)

    Nagy, A. M.; Sweilam, N. H.

    2014-06-01

    In this paper, we present an accurate numerical method for solving fractional Hodgkin-Huxley model. A non-standard finite difference method (NSFDM) is implemented to study the dynamic behaviors of the proposed model. The Grünwald-Letinkov definition is used to approximate the fractional derivatives. Numerical results are presented graphically reveal that NSFDM is easy to implement, effective and convenient for solving the proposed model.

  4. EXPONENTIAL TIME DIFFERENCING FOR HODGKIN-HUXLEY-LIKE ODES.

    Science.gov (United States)

    Börgers, Christoph; Nectow, Alexander R

    2013-01-01

    Several authors have proposed the use of exponential time differencing (ETD) for Hodgkin-Huxley-like partial and ordinary differential equations (PDEs and ODEs). For Hodgkin-Huxley-like PDEs, ETD is attractive because it can deal effectively with the stiffness issues that diffusion gives rise to. However, large neuronal networks are often simulated assuming "space-clamped" neurons, i.e., using the Hodgkin-Huxley ODEs, in which there are no diffusion terms. Our goal is to clarify whether ETD is a good idea even in that case. We present a numerical comparison of first- and second-order ETD with standard explicit time-stepping schemes (Euler's method, the midpoint method, and the classical fourth-order Runge-Kutta method). We find that in the standard schemes, the stable computation of the very rapid rising phase of the action potential often forces time steps of a small fraction of a millisecond. This can result in an expensive calculation yielding greater overall accuracy than needed. Although it is tempting at first to try to address this issue with adaptive or fully implicit time-stepping, we argue that neither is effective here. The main advantage of ETD for Hodgkin-Huxley-like systems of ODEs is that it allows underresolution of the rising phase of the action potential without causing instability, using time steps on the order of one millisecond. When high quantitative accuracy is not necessary and perhaps, because of modeling inaccuracies, not even useful, ETD allows much faster simulations than standard explicit time-stepping schemes. The second-order ETD scheme is found to be substantially more accurate than the first-order one even for large values of Δt.

  5. On Eugene A. Nida's Functional Equivalence%On Eugene A.Nida's Functional Equivalence

    Institute of Scientific and Technical Information of China (English)

    赵玲

    2016-01-01

    Eugene A. Nida's Functional Equivalence is a very useful theory in translation. This theory considers that translation is transference of the source language into the meaning of the target language in the way the author intended the text. It has a deep influence on translation.

  6. Action potential initiation in the hodgkin-huxley model.

    Directory of Open Access Journals (Sweden)

    Lucy J Colwell

    2009-01-01

    Full Text Available A recent paper of B. Naundorf et al. described an intriguing negative correlation between variability of the onset potential at which an action potential occurs (the onset span and the rapidity of action potential initiation (the onset rapidity. This correlation was demonstrated in numerical simulations of the Hodgkin-Huxley model. Due to this antagonism, it is argued that Hodgkin-Huxley-type models are unable to explain action potential initiation observed in cortical neurons in vivo or in vitro. Here we apply a method from theoretical physics to derive an analytical characterization of this problem. We analytically compute the probability distribution of onset potentials and analytically derive the inverse relationship between onset span and onset rapidity. We find that the relationship between onset span and onset rapidity depends on the level of synaptic background activity. Hence we are able to elucidate the regions of parameter space for which the Hodgkin-Huxley model is able to accurately describe the behavior of this system.

  7. Eugenics, Mental Deficiency and Fabian Socialism between the Wars.

    Science.gov (United States)

    Ray, L. J.

    1983-01-01

    Eugenics was not exclusively the concern of conservatives; it also appealed to certain socialists, particularly those whose middle class status was dependent upon their expert services and who believed that social problems could be resolved scientifically. Reasons for the appeal of eugenics to this group are discussed. (IS)

  8. Science in the Publicity Laboratory: The Case of Eugenics.

    Science.gov (United States)

    Caudill, Edward

    The eugenicists of the 1920s and 1930s aggressively pursued media attention and sought policy change for their cause of improving the human race by selective breeding. Eugenics gained momentum in the United States when the American Eugenics Society (AES) was organized in 1921. Policy formation and information dissemination were central to the…

  9. Rational subjects, marriage counselling and the conundrums of eugenics.

    Science.gov (United States)

    Gerodetti, Natalia

    2008-06-01

    Against the background of degeneration and the perceived threat to the nation's health and stock, family politics came to constitute an important site for eugenic discourses and interventions. Eugenic regulation of reproductive sexuality and marriage was not only pursued through 'negative' eugenics but also through educational policies targeted at young adults and youth. Switzerland serves as a useful case to explore a general idea, namely the limitations for eugenicists of exploiting the concept of a rational subject in order to achieve their ends. Practices of 'positive eugenics' crucially hinged on the utilitarian principle of rationality underpinning positive eugenics which this paper seeks to elaborate. Eugenicists devised tools to deal efficiently with social problems on a collective as well as an individual basis by deploying technologies of government which conceived individuals to be members of a population who were each held responsible for the generation of healthy future generations. As a form of 'sustaining, multiplying and ordering life' eugenics thus relied on the premise that its ideas would be adopted through an appeal to rationality and, where this was insufficient, through a series of coercive measures. Relying on conviction and education about the merits of eugenics, however, posed particular problems to positive eugenic thinking and practice.

  10. The New Eugenics: Black Hyper-Incarceration and Human Abatement

    Directory of Open Access Journals (Sweden)

    James C. Oleson

    2016-10-01

    Full Text Available In the early twentieth century, the eugenics movement exercised considerable influence over domestic US public policy. Positive eugenics encouraged the reproduction of “fit” human specimens while negative eugenics attempted to reduce the reproduction of “unfit” specimens like the “feebleminded” and the criminal. Although eugenics became a taboo concept after World War II, it did not disappear. It was merely repackaged. Incarceration is no longer related to stated eugenic goals, yet incapacitation in prisons still exerts a prophylactic effect on human reproduction. Because minorities are incarcerated in disproportionately high numbers, the prophylactic effect of incarceration affects them most dramatically. In fact, for black males, the effect of hyper-incarceration might be so great as to depress overall reproduction rates. This article identifies some of the legal and extralegal variables that would be relevant for such an analysis and calls for such an investigation.

  11. Proceedings of the National Silviculture Workshop: Economics Of Silvicultural Investments; Eugene, OR; May 16-20, 1983

    Science.gov (United States)

    Clark Row; Charles Palmer; Robert M. Randall; Tom Ortman; James P. Merzenich; Gary Manning; George Howe; Jim McDivitt; Chris Hansen; Willard R. Fey; Vernon L. Robinson; K. E. Sleavin; K. N. Johnson; Roger D. Fight; L. O. (Pete) Stanger; Lee Medema; Christopher D. Risbrudt; Richard W. Guldin; Richard Greenhalgh; Mike Skinner; John Fiske; Thomas J. Mills; John H. Beuter

    1983-01-01

    The 1983 Silviculture Workshop was held in Eugene, Oregon, and the Willamette National Forest. The purpose of the workshop was to review and discuss the requirements by laws, regulations, and Forest Service policy of the need for and uses of economic analyses in silvicultural program planning and development.

  12. Propulsion by light: a tribute to the German pioneer Eugen Saenger (Plenary Paper)

    Science.gov (United States)

    Bohn, Willy L.

    2004-09-01

    Although the laser was not yet invented Eugen Saenger, one of the most prominent German personalities in the early development of rocket science and technology suggested to use photons for the propulsion of spacecrafts in the fifties. In contrast to current schemes which are basically aimed at laser induced ablation processes, Eugen Saenger started with the idea of using the radiation pressure itself for propulsion purposes. A review of his pioneering work in that area will be supported by numerous historical documents and personal remembrance showing his effort to promote unconventional ideas. The paper also emphasizes how some of the original concepts are being revisited and partly implemented by using today"s laser technology.

  13. On the concept of eugenics: preliminaries to a critical appraisal

    Directory of Open Access Journals (Sweden)

    Neri Demetrio

    1999-01-01

    Full Text Available This paper's main issue is linked to what can be foreseen as the increasing capability of medical genetics to modify the genetic composition of the human species through direct interventions in the human genome for medical and non-medical purposes, i.e., the 'risk' of a resurgence of eugenics. In current discussions on the topic (briefly presented in the first section, the 'phantom of eugenics' is raised several times, but there is a great deal of confusion on what counts as eugenics, partly because of broad conceptual disagreement over the notion itself. Furthermore, according to some scholars there is no hope of overcoming this unsatisfactory conceptual uncertainty. Partly challenging this opinion, the second and third sections of this paper attempt to identify some basic features which could be seen as intrinsically linked to the notion of eugenics, with the aim of reducing the range of conceptual disagreement as a preliminary step in bringing into focus what exactly is wrong with practicing eugenics. The subsequent sections deal with the substantive issue of whether or not to practice eugenics from the point of view of the interest of future generations in the human species' genetic composition. The main moral arguments for and against eugenics are examined from the point of view of our obligations towards future generations, and the conclusion is in favor of a cautious 'open-door' position.

  14. On the concept of eugenics: preliminaries to a critical appraisal

    Directory of Open Access Journals (Sweden)

    Demetrio Neri

    Full Text Available This paper's main issue is linked to what can be foreseen as the increasing capability of medical genetics to modify the genetic composition of the human species through direct interventions in the human genome for medical and non-medical purposes, i.e., the 'risk' of a resurgence of eugenics. In current discussions on the topic (briefly presented in the first section, the 'phantom of eugenics' is raised several times, but there is a great deal of confusion on what counts as eugenics, partly because of broad conceptual disagreement over the notion itself. Furthermore, according to some scholars there is no hope of overcoming this unsatisfactory conceptual uncertainty. Partly challenging this opinion, the second and third sections of this paper attempt to identify some basic features which could be seen as intrinsically linked to the notion of eugenics, with the aim of reducing the range of conceptual disagreement as a preliminary step in bringing into focus what exactly is wrong with practicing eugenics. The subsequent sections deal with the substantive issue of whether or not to practice eugenics from the point of view of the interest of future generations in the human species' genetic composition. The main moral arguments for and against eugenics are examined from the point of view of our obligations towards future generations, and the conclusion is in favor of a cautious 'open-door' position.

  15. 朱利安·赫胥黎%Julian Huxley

    Institute of Scientific and Technical Information of China (English)

    焦玉洁

    2011-01-01

    @@ 朱利安·赫胥黎(Julian Huxley),1887年6月生于英国伦敦市,1975年2月去世,是英网著名的动物学家、哲学家、教育家和作家.他曾担任联合国教育科学文化组织第一届总干事,也是世界自然基金会(WWF)创始成员之一.作为生物学家,他提倡自然选择,是现代综合进化论领军人物.

  16. Concluding Commentary: Response to Eugene and Kiyo

    Directory of Open Access Journals (Sweden)

    E. Jayne White

    2014-10-01

    Full Text Available At the risk of speaking on his behalf I could almost swear I heard Bakhtin laughing gleefully over my shoulder as I read this fascinating dialogue between Eugene and Kiyo.  His reason for this might be partly inspired by the glaring misunderstandings both men reveal through their associated interplay with key pedagogical concepts. While polemic in nature, it occurs to me, somewhat ironically, that each man makes the same careful, empirically located, argument from different cultural and philosophical standpoints. At the centre of their debate is the concept of pedagogy and its capacity to promote ‘authentic’ learning. Despite this shared agenda their interpretations of key terms are often at variance and, as a result, they passionately bang their heads against each other in vehement misunderstanding that makes for what Bakhtin (2004 would describe as “lively and expressive” debate (p. 24 on this topic.

  17. [Beyond eugenics: posthumanism as Homo patiens denials].

    Science.gov (United States)

    Ballesteros Llompart, Jesús

    2012-01-01

    Throughout history there have been attempts to overcome human limitations by means of technique. The novelty of the 20th century has been to try to extirpate all the faults, the suffering, the disease, and even the death. This power has been attributed successively to machines (the futurism), to the genetic information (the eugenism) and to the electronic information (the posthumanism). In all cases, it's unknown the distinction between inevitable faults, ontological deficiencies, as the reality of death, and avoidable ones, sociological deficiencies, as the deaths due to circumstances as lack of drinkable water, of medicaments, wars or any other type of violence. The due way of confronting the human faults is to try to eradicate their avoidable causes and at the same time to understand the sense of those that cannot be avoided, as occasion of the self-overcoming and the opening to the Transcendence.

  18. [The analysis of the eugenic culture in ancient China].

    Science.gov (United States)

    Jiang, Gong-Cheng; Zong, Hong

    2010-09-01

    There was a centuries-old culture of eugenics in ancient China. We should have comprehensive and objective cognition of this tradition. The ancient people did not generally advocate marrying at a mature age as do people of modern times. They not only considered the prepotency, but also were influenced by other complicated social factors on the problem of mate selection. Although advocates of coition techniques claimed the purpose of prepotency, the eugenic effect of coition techniques deserved to be suspect. Regarding the aspect of embryo conservation and care, the most significant thing was not so-called "prenatal education", but various antenatal care methods which were proposed by TCM scholars. By making a comparison with modern eugenics, the ancient eugenics had the characteristics of valuing the male child only, commiserating with deformity and being based on familial values.

  19. Between Germanic and Latin eugenics: Portugal, 1930-1960

    Directory of Open Access Journals (Sweden)

    Richard Mark Cleminson

    Full Text Available Abstract This article assesses critically the participation of Portuguese eugenicists in “Latin eugenics” and traces the continuities and discontinuities with respect to this model. In particular, it focuses on a number of examples of more “Germanic” eugenics in contrast and in comparison to Latin versions of eugenics. In the former category, Eusébio Tamagnini, José Ayres de Azevedo and Leopoldina Ferreira de Paulo are considered; in the latter category, especially the work of Almerindo Lessa on “racial mixing” is considered. The conclusions suggest that we should seek diversity in both Latin and northern European eugenic models while at the same time placing Portugal within the array of possible versions of eugenics during the first half of the twentieth century.

  20. Assisted procreation and its relationship to genetics and eugenics.

    Science.gov (United States)

    Ricci, Mariella Lombardi

    2009-01-01

    The article below is intended to reflect on whether or not a eugenic tendency constitutes an intrinsic element of human fertilization in vitro. The author outlines ideas and circumstances which characterized the foundation and propagation of eugenics between the eighteenth and nineteenth centuries. A brief discussion follows on some of the standard procedures of in vitro fertilization, and in particular, those which manifest a trace or hint of eugenics--heterologous fertilization and sperm banking, preimplantation genetic diagnosis (PGD) and embryo selection--practices which, nonetheless, are used on a large scale and shed light on both the essence of procreative medicine and on the current cultural environment. The objective of the article is to explore whether it is possible to eliminate the eugenic connotations without foregoing the benefits of technical and scientific progress.

  1. Eugenics in Buenos Aires: discourses, practices, and historiography.

    Science.gov (United States)

    Armus, Diego

    2016-12-01

    Since the early 1990s, a series of studies underscored the overwhelming presence of positive eugenics in modern Argentina. These works emphasized the marginal role which discourse on eugenics took on violent methods for selection. In recent years, this point of view has shifted, emphasizing the conceptual viscosity of eugenics as well as the presence of negative eugenic discourses. This paper discusses these historiographic trends, and also dwells on the narratives that those perspectives articulated in relation to the question of sterilization and regulation of marriage of those who had tuberculosis in Buenos Aires during the first half of the twentieth century. This example stresses the need to examine discourse as well as practices in understanding and making sense of the past.

  2. Eugenics without the state: anarchism in Catalonia, 1900-1937.

    Science.gov (United States)

    Cleminson, Richard

    2008-06-01

    Current historiography has considered eugenics to be an emanation from state structures or a movement which sought to appeal to the state in order to implement eugenic reform. This paper examines the limitations of that view and argues that it is necessary to expand our horizons to consider particularly working-class eugenics movements that were based on the dissemination of knowledge about sex and which did not aspire to positions of political power. The paper argues that anarchism, with its contradictory practice afforded by the convulsive social situation of the Civil War in Spain, allows us to assess critically the parameters of the social action of eugenics, its many alliances, and its struggle for existence in changing political circumstances not of its own making.

  3. Energy and information in Hodgkin-Huxley neurons

    CERN Document Server

    Moujahid, A; Torrealdea, F J

    2015-01-01

    The generation of spikes by neurons is energetically a costly process and the evaluation of the metabolic energy required to maintain the signalling activity of neurons a challenge of practical interest. Neuron models are frequently used to represent the dynamics of real neurons but hardly ever to evaluate the electrochemical energy required to maintain that dynamics. This paper discusses the interpretation of a Hodgkin-Huxley circuit as an energy model for real biological neurons and uses it to evaluate the consumption of metabolic energy in the transmission of information between neurons coupled by electrical synapses, i.e. gap junctions. We show that for a single postsynaptic neuron maximum energy efficiency, measured in bits of mutual information per ATP molecule consumed, requires maximum energy consumption. On the contrary, for groups of parallel postsynaptic neurons we determine values of the synaptic conductance at which the energy efficiency of the transmission presents clear maxima at relatively ver...

  4. Hodgkin-Huxley neurons with defective and blocked ion channels

    Science.gov (United States)

    Pang, James Christopher S.; Bantang, Johnrob Y.

    2015-03-01

    We utilize the original Hodgkin-Huxley (HH) model to consider the effects of defective ion channels to the temporal response of neurons. Statistics of firing rate and inter-spike interval (ISI) reveal that production of action potentials (APs) in neurons is not sensitive to changes in membrane conductance for sodium and potassium ions, as well as to the reversal potential for sodium ions, as long as the relevant parameters do not exceed 13% from their normal levels. We also found that blockage of a critical fraction of either sodium or potassium channels (dependent on constant input current) respectively limits the firing activity or increases spontaneous spiking activity of neurons. Our model may be used to guide experiment designs related to ion channel control drug development.

  5. Spontaneous spiking in an autaptic Hodgkin-Huxley set up

    CERN Document Server

    Li, Yunyun; Hanggi, Peter; Schimansky-Geier, Lutz

    2010-01-01

    The effect of intrinsic channel noise is investigated for the dynamic response of a neuronal cell with a delayed feedback loop. The loop is based on the so-called autapse phenomenon in which dendrites establish not only connections to neighboring cells but as well to its own axon. The biophysical modeling is achieved in terms of a stochastic Hodgkin-Huxley model containing such a built in delayed feedback. The fluctuations stem from intrinsic channel noise, being caused by the stochastic nature of the gating dynamics of ion channels. The influence of the delayed stimulus is systematically analyzed with respect to the coupling parameter and the delay time in terms of the interspike interval histograms and the average interspike interval. The delayed feedback manifests itself in the occurrence of bursting and a rich multimodal interspike interval distribution, exhibiting a delay-induced reduction of the spontaneous spiking activity at characteristic frequencies. Moreover, a specific frequency-locking mechanism ...

  6. Edge detection based on Hodgkin-Huxley neuron model simulation.

    Science.gov (United States)

    Yedjour, Hayat; Meftah, Boudjelal; Lézoray, Olivier; Benyettou, Abdelkader

    2017-04-03

    In this paper, we propose a spiking neural network model for edge detection in images. The proposed model is biologically inspired by the mechanisms employed by natural vision systems, more specifically by the biologically fulfilled function of simple cells of the human primary visual cortex that are selective for orientation. Several aspects are studied in this model according to three characteristics: feedforward spiking neural structure; conductance-based model of the Hodgkin-Huxley neuron and Gabor receptive fields structure. A visualized map is generated using the firing rate of neurons representing the orientation map of the visual cortex area. We have simulated the proposed model on different images. Successful computer simulation results are obtained. For comparison, we have chosen five methods for edge detection. We finally evaluate and compare the performances of our model toward contour detection using a public dataset of natural images with associated contour ground truths. Experimental results show the ability and high performance of the proposed network model.

  7. New multi-soliton solutions for generalized Burgers-Huxley equation

    Directory of Open Access Journals (Sweden)

    Liu Jun

    2013-01-01

    Full Text Available The double exp-function method is used to obtain a two-soliton solution of the generalized Burgers-Huxley equation. The wave has two different velocities and two different frequencies.

  8. Hugh E. Huxley: cambiando el paradigma de la contracción muscular, desde dentro. [Hugh E. Huxley: changing from inside the paradigm of muscle contraction].

    OpenAIRE

    Adolfo Araci

    2014-01-01

    Desde un punto de vista físico se puede entender la fibra muscular como un motor, es decir, un sistema capaz de transformar la energía química en energía mecánica, que se utiliza para realizar un trabajo. Por lo tanto, para entender cómo ocurre dicho proceso de transformación es necesario conocer la ultraestructura de la fibra muscular. Esta es, sin duda, la principal aportación al acervo científico del recientemente fallecido Hugh Emor Huxley (1924-2013). Huxley se graduó en Física en el Chr...

  9. Hugh E. Huxley: cambiando el paradigma de la contracción muscular, desde dentro. [Hugh E. Huxley: changing from inside the paradigm of muscle contraction].

    OpenAIRE

    Adolfo Araci

    2014-01-01

    Desde un punto de vista físico se puede entender la fibra muscular como un motor, es decir, un sistema capaz de transformar la energía química en energía mecánica, que se utiliza para realizar un trabajo. Por lo tanto, para entender cómo ocurre dicho proceso de transformación es necesario conocer la ultraestructura de la fibra muscular. Esta es, sin duda, la principal aportación al acervo científico del recientemente fallecido Hugh Emor Huxley (1924-2013). Huxley se graduó en Física en el Chr...

  10. Flinders Petrie and Eugenics at UCL

    Directory of Open Access Journals (Sweden)

    Kathleen L. Sheppard

    2010-05-01

    Full Text Available William Matthew Flinders Petrie is considered the father of scientific archaeology and is credited with developing a chronology of Ancient Egypt using the nondescript artefacts that other archaeologists had ignored. He occupied the first chair of Egyptology in England, and was also well-known for the museum built around his personal collection of Egyptian artifacts at University College London. Petrie's archaeological work has been studied by scholars, from various disciplines, for its scholarly, cultural, and historical value, while Petrie's life and career outside of archaeology have been the subject of relatively little study. Petrie himself wrote two life stories: the first, 'Ten Years Digging in Egypt, 1881–1891' (1892, detailed the years before his professorship at UCL; in 1932 he published his second, more complete autobiography, 'Seventy Years in Archaeology'. After he died in 1942 there were various obituaries and memorials that outlined his life and major achievements in archaeology. There was very little written about Petrie the man until 1985, when Margaret Drower's 'Flinders Petrie: A Life in Archaeology' was published; it remains the most comprehensive work on Petrie's life. A thin volume of the correspondence of Hilda and Flinders Petrie also allows a glimpse into life on excavation. In short, much of what is known about Petrie focuses on his excavations in Egypt, his time as Professor of Egyptology at University College London, or the museum that bears his name. Subsequently, as a historical matter, Petrie's work in the discipline of eugenics has rarely been discussed as part of his career.

  11. The Testing and Militarization of K-12 Education: Eugenic Assault on Urban School Populations

    Science.gov (United States)

    Hartlep, Nicholas Daniel

    2010-01-01

    This paper attempts to discuss eugenics in education and how this eugenic legacy continues to haunt American schooling and nonwhite students. Eugenic praxes and pedagogy continue to proliferate inside the American school systems' teachers may be unaware that they are teaching in such a way that maintains this ethos. This paper and seminar's…

  12. Eugen Goldstein and his Laboratory Work at the Berlin Observatory

    Science.gov (United States)

    Hedenus, Michael

    At the end of the 19th century the astronomer and director of the Berlin Observatory, Wilhelm Foerster, started an extraordinary research project: He asked the physicist Eugen Goldstein to examine the nature of electricity in space experimentally. Eugen Goldstein (1850-1930) was one of the most deserving pioneers in the field of electricity, e. g. he discovered the canal rays and he introduced the term ``cathode ray''. He became assistent at the Berlin Observatory and his official duty was the research on relations between electricity and cosmic phenomena. As a result Goldstein successfully reproduced comet tails in gas discharge tubes. My speech is about the biography of Eugen Goldstein and his work at the Berlin Observatory. I will discuss some of his experiments and show a reproduction of his artificial comet tails.

  13. The sex reform movement and eugenics in interwar Poland.

    Science.gov (United States)

    Gawin, Magdalena

    2008-06-01

    This paper focuses on the relations between a liberal group of sex reformers, consisting of writers and literary critics, and physicians from the Polish Eugenics Society in interwar Poland. It illustrates the paradoxes of the mutual co-operation between these two groups during the 1930s and analyses the reason why compulsory sterilisation was rejected by politicians. From the early 1930s two movements began to forge an alliance in Poland: the sexual reform movement which advocated freedom of the individual, and eugenics, which called for limiting the freedom of the individual for the collective good. This paper draws attention to several issues which emerged as part of this collaboration: population politics, the relationship between reformers, eugenicists and state institutions, and the question of how both movements--eugenics and sexual reform--perceived the question of sexuality, birth control and abortion. It will also focus on those aspects of their thinking that led to mutual co-operation.

  14. Eugenics, genetics, and mental illness stigma in Chinese Americans.

    Science.gov (United States)

    WonPat-Borja, Ahtoy J; Yang, Lawrence H; Link, Bruce G; Phelan, Jo C

    2012-01-01

    The increasing interest in the genetic causes of mental disorders may exacerbate existing stigma if negative beliefs about a genetic illness are generally accepted. China's history of policy-level eugenics and genetic discrimination in the workplace suggests that Chinese communities will view genetic mental illness less favorably than mental illness with non-genetic causes. The aim of this study is to identify differences between Chinese Americans and European Americans in eugenic beliefs and stigma toward people with genetic mental illness. We utilized data from a 2003 national telephone survey designed to measure how public perceptions of mental illness differ if the illness is described as genetic. The Chinese American (n = 42) and European American (n = 428) subsamples were analyzed to compare their support of eugenic belief items and measures of stigma. Chinese Americans endorsed all four eugenic statements more strongly than European Americans. Ethnicity significantly moderated the relationship between genetic attribution and three out of five stigma outcomes; however, genetic attribution actually appeared to be de-stigmatizing for Chinese Americans while it increased stigma or made no difference for European Americans. Our findings show that while Chinese Americans hold more eugenic beliefs than European Americans, these attributions do not have the same effect on stigma as they do in Western cultures. These results suggest that future anti-stigma efforts must focus on eugenic attitudes as well as cultural beliefs for Chinese Americans, and that the effects of genetic attributions for mental illness should be examined relative to other social, moral, and religious attributions common in Chinese culture.

  15. Eugen Goldstein and his laboratory work at Berlin Observatory

    Science.gov (United States)

    Hedenus, M.

    2002-07-01

    At the end of the 19th century, the astronomer Wilhelm Foerster, director of Berlin Observatory, initiated an extraordinary research project: He asked the physicist Eugen Goldstein to examine experimentally the nature of electricity in space. Eugen Goldstein (1850-1930) was one of the most deserving pioneers in the field of electricity. He discovered, e.g., the canal rays, and he introduced the term cathode ray. He became assistent at Berlin Observatory, and his official duty was the research on relations between electricity and cosmic phenomena. As a result, Goldstein successfully reproduced comet tails in gas discharge tubes.

  16. Exhibiting eugenics: response and resistance to a hidden history.

    Science.gov (United States)

    Brave, Ralph; Sylva, Kathryn

    2007-01-01

    Human Plants, Human Harvest: The Hidden History of California Eugenics is the first-ever exhibition on the history of eugenics in California. The disappearance of this history for half a century, and the consequent absence of a "collective menory", were the primary factors determining the exhibit's sttrcture and content. Responses to the exhibit confirmed that most visitors "never knew" about this history. The exhibit is described in some detail, with selected imagery from the exhibit reproduced. After the initial exhibition, responses of other museums and foundation officials revealed a continuing resistance to this history being publicly displayed, though the sources of resistance varied.

  17. [Thomas H.Huxley--the naval doctor who became Darwin's bulldog].

    Science.gov (United States)

    Hauge, A

    2000-12-10

    Thomas H. Huxley (1825-1895) was an English physician and biologist who had a deep impact on the Victorian age. More than any other at his time he introduced scientifically based values. As a member of London's school board he brought science into the curriculum, encouraging school-children to ask questions and to make their own observations. Huxley came from a lower middle class family with little money. By sheer determination and hard work he managed to get a medical education at Charing Cross Hospital Medical School. He then obtained a posting on H.M.S. Rattlesnake, which gave him a chance to explore the southern seas and to study marine species. The results were published by the Royal Society of which Huxley became a member at the age of 26, and later its president. After several years of uncertainty he secured a position at the Royal School of Mines, which he transformed into the Imperial College of Science. He was a prolific scientist with wide interests, doing valuable work in paleontology, taxonomy and ethnology. Huxley wrote numerous essays on philosophy and scientific subjects. He coined the word agnostic to explain his attitude to Christian dogma. His style was clear and direct, and his essays still read very well. However, Huxley is now mostly, perhaps unfairly, remembered for his defence of Darwin's theory of evolution. In his book Evidence as to man's place in nature, Huxley, in contrast to Darwin, deals with the evolution of humans, mainly based on comparative anatomy. Huxley advocated a firmly held belief that scientific truths will have a liberating effect on the minds of men. His lectures on scientific subjects attracted large audiences of people who had not had the benefit of a higher education.

  18. Spontaneous spiking in an autaptic Hodgkin-Huxley setup

    Science.gov (United States)

    Li, Yunyun; Schmid, Gerhard; Hänggi, Peter; Schimansky-Geier, Lutz

    2010-12-01

    The effect of intrinsic channel noise is investigated for the dynamic response of a neuronal cell with a delayed feedback loop. The loop is based on the so-called autapse phenomenon in which dendrites establish connections not only to neighboring cells but also to its own axon. The biophysical modeling is achieved in terms of a stochastic Hodgkin-Huxley model containing such a built in delayed feedback. The fluctuations stem from intrinsic channel noise, being caused by the stochastic nature of the gating dynamics of ion channels. The influence of the delayed stimulus is systematically analyzed with respect to the coupling parameter and the delay time in terms of the interspike interval histograms and the average interspike interval. The delayed feedback manifests itself in the occurrence of bursting and a rich multimodal interspike interval distribution, exhibiting a delay-induced reduction in the spontaneous spiking activity at characteristic frequencies. Moreover, a specific frequency-locking mechanism is detected for the mean interspike interval.

  19. The ISI distribution of the stochastic Hodgkin-Huxley neuron.

    Science.gov (United States)

    Rowat, Peter F; Greenwood, Priscilla E

    2014-01-01

    The simulation of ion-channel noise has an important role in computational neuroscience. In recent years several approximate methods of carrying out this simulation have been published, based on stochastic differential equations, and all giving slightly different results. The obvious, and essential, question is: which method is the most accurate and which is most computationally efficient? Here we make a contribution to the answer. We compare interspike interval histograms from simulated data using four different approximate stochastic differential equation (SDE) models of the stochastic Hodgkin-Huxley neuron, as well as the exact Markov chain model simulated by the Gillespie algorithm. One of the recent SDE models is the same as the Kurtz approximation first published in 1978. All the models considered give similar ISI histograms over a wide range of deterministic and stochastic input. Three features of these histograms are an initial peak, followed by one or more bumps, and then an exponential tail. We explore how these features depend on deterministic input and on level of channel noise, and explain the results using the stochastic dynamics of the model. We conclude with a rough ranking of the four SDE models with respect to the similarity of their ISI histograms to the histogram of the exact Markov chain model.

  20. Final-Offer Arbitration: "Sudden Death" in Eugene

    Science.gov (United States)

    Long, Gary; Feuille, Peter

    1974-01-01

    A case study on final offer arbitration experiences in Eugene, Oregon, is presented and discussed. Basic criticisms leveled against the final-offer system are opposed by the authors and evidence is given in support of the use of final-offer arbitration. (DS)

  1. Chris Woodhead: A New Champion of Eugenic Theories

    Science.gov (United States)

    Chitty, Clyde

    2009-01-01

    Eugenic Theories are clearly alive and well in present-day society--or this is at least true of those theories relating to the passing on of abilities and talents from one generation to the next. This depressing thought was prompted by a reading of Chris Woodhead's latest book "A Desolation of Learning."

  2. What Was Wrong with Eugenics? Conflicting Narratives and Disputed Interpretations

    Science.gov (United States)

    Paul, Diane B.

    2014-01-01

    Although it is often taken for granted that eugenics is odious, exactly what makes it so is far from obvious. The existence of considerable interpretative flexibility is evident in the disparate policy lessons for contemporary reproductive genetics (or "reprogenetics") that have been derived from essentially the same set of historical…

  3. The Legitimizing Function of Judicial Rhetoric in the Eugenics Controversy.

    Science.gov (United States)

    Hasian, Marouf, Jr.; Croasmun, Earl

    1992-01-01

    Investigates the possibility that judicial policymaking is responsive to the situational exigencies created in part through public discourse. Investigates the elite and public perspectives regarding the eugenics controversy in the 1920s to explore the emergent relationship between the public and technical spheres of argument. (SR)

  4. "The Bell Curve" and Carrie Buck: Eugenics Revisited.

    Science.gov (United States)

    Smith, J. David

    1995-01-01

    The 1994 publication of "The Bell Curve" by R. Herrnstein and C. Murray is compared to other examples of eugenic principles, including the sterilization of "feebleminded" Carrie Buck, family degeneracy studies focusing on lower class Caucasian families, and other works that view the poorest and least educated members of society…

  5. Thomas Huxley and the rat placenta in the early debates on evolution.

    Science.gov (United States)

    Pijnenborg, R; Vercruysse, L

    2004-01-01

    The 19th century debates on mammalian classification in the light of the new evolutionary thinking led to controversies between Thomas Huxley and Richard Owen concerning the value of the placenta as a representative key organ. As a main point in his argument, Huxley provided a detailed description of a sectioned rat placenta, highlighting the importance of decidualization of the uterus as an argument supporting an evolutionary relationship between rodents, insectivores and primates, an idea hotly contested by Owen. In addition, he illustrated and correctly interpreted the maternal blood supply from uterus to placenta in striking detail. During the succeeding decades the key role of trophoblast in placenta formation was discovered, and the decidua became neglected in later comparative studies. Nevertheless, at the present time trophoblast-decidual interaction is regarded as an extremely important feature of placental development in both primates and rodents, and Huxley can therefore rightfully be considered as an early pioneer in placental research.

  6. Challenging normative orthodoxies in depression: Huxley's Utopia or Dante's Inferno?

    Science.gov (United States)

    Cutcliffe, John R; Lakeman, Richard

    2010-04-01

    Although there appears to be a widespread consensus that depression is a ubiquitous human experience, definitions of depression, its prevalence, and how mental health services respond to it have changed significantly over time, particularly during recent decades. Epistemological limitations notwithstanding, it is now estimated that approximately 121 million people experience depression. At the same time, it should be acknowledged that the last two decades have seen the widespread acceptance of depression as a chemical imbalance and a massive corresponding increase in the prescription of antidepressants, most notably of selective serotonin reuptake inhibitors (SSRIs). However, questions have been raised about the effectiveness and iatrogenic side effects of antidepressants; related questions have also been asked about whose interests are served by the marketing and sales of these drugs. Accordingly, this article attempts to problematize the normative orthodoxy concerning depression and creates a "space" in which an alternative can be articulated and enacted. In so doing, the article finds that the search for a world where the automatic response to depression is a pharmacological intervention not only ignores the use of alternative efficacious treatment options but may also inhibit the persons' chance to explore the meaning of their experience and thus prevent people from individual growth and personal development. Interestingly, in worlds analogous to this pharmacologically induced depression-free state, such as utopias like that in Huxley's Brave New World, no "properly conditioned citizen" is depressed or suicidal. Yet, in the same Brave New World, no one is free to suffer, to be different, or crucially, to be independent. Copyright 2010 Elsevier Inc. All rights reserved.

  7. Principal Dynamic Mode Analysis of the Hodgkin–Huxley Equations

    Science.gov (United States)

    Eikenberry, Steffen E.; Marmarelis, Vasilis Z.

    2015-01-01

    We develop an autoregressive model framework based on the concept of Principal Dynamic Modes (PDMs) for the process of action potential (AP) generation in the excitable neuronal membrane described by the Hodgkin–Huxley (H–H) equations. The model's exogenous input is injected current, and whenever the membrane potential output exceeds a specified threshold, it is fed back as a second input. The PDMs are estimated from the previously developed Nonlinear Autoregressive Volterra (NARV) model, and represent an efficient functional basis for Volterra kernel expansion. The PDM-based model admits a modular representation, consisting of the forward and feedback PDM bases as linear filterbanks for the exogenous and autoregressive inputs, respectively, whose outputs are then fed to a static nonlinearity composed of polynomials operating on the PDM outputs and cross-terms of pair-products of PDM outputs. A two-step procedure for model reduction is performed: first, influential subsets of the forward and feedback PDM bases are identified and selected as the reduced PDM bases. Second, the terms of the static nonlinearity are pruned. The first step reduces model complexity from a total of 65 coefficients to 27, while the second further reduces the model coefficients to only eight. It is demonstrated that the performance cost of model reduction in terms of out-of-sample prediction accuracy is minimal. Unlike the full model, the eight coefficient pruned model can be easily visualized to reveal the essential system components, and thus the data-derived PDM model can yield insight into the underlying system structure and function. PMID:25630480

  8. Principal dynamic mode analysis of the Hodgkin-Huxley equations.

    Science.gov (United States)

    Eikenberry, Steffen E; Marmarelis, Vasilis Z

    2015-03-01

    We develop an autoregressive model framework based on the concept of Principal Dynamic Modes (PDMs) for the process of action potential (AP) generation in the excitable neuronal membrane described by the Hodgkin-Huxley (H-H) equations. The model's exogenous input is injected current, and whenever the membrane potential output exceeds a specified threshold, it is fed back as a second input. The PDMs are estimated from the previously developed Nonlinear Autoregressive Volterra (NARV) model, and represent an efficient functional basis for Volterra kernel expansion. The PDM-based model admits a modular representation, consisting of the forward and feedback PDM bases as linear filterbanks for the exogenous and autoregressive inputs, respectively, whose outputs are then fed to a static nonlinearity composed of polynomials operating on the PDM outputs and cross-terms of pair-products of PDM outputs. A two-step procedure for model reduction is performed: first, influential subsets of the forward and feedback PDM bases are identified and selected as the reduced PDM bases. Second, the terms of the static nonlinearity are pruned. The first step reduces model complexity from a total of 65 coefficients to 27, while the second further reduces the model coefficients to only eight. It is demonstrated that the performance cost of model reduction in terms of out-of-sample prediction accuracy is minimal. Unlike the full model, the eight coefficient pruned model can be easily visualized to reveal the essential system components, and thus the data-derived PDM model can yield insight into the underlying system structure and function.

  9. Stimulus-dependent refractoriness in the Frankenhaeuser-Huxley model.

    Science.gov (United States)

    Morse, R P; Allingham, D; Stocks, N G

    2015-10-07

    Phenomenological neural models, such as the leaky integrate-and-fire model, normally have a fixed refractory time-course that is independent of the stimulus. The recovery of threshold following an action potential is typically based on physiological experiments that use a two-pulse paradigm in which the first pulse is suprathreshold and causes excitation and the second pulse is used to determine the threshold at various intervals following the first. In such experiments, the nerve is completely unstimulated between the two pulses. This contrasts the receptor stimuli in normal physiological systems and the electrical stimuli used by cochlear implants and other neural prostheses. A numerical study of the Frankenhaeuser-Huxley conductance-based model of nerve fibre was therefore undertaken to investigate the effect of stimulation on refractoriness. We found that the application of a depolarizing stimulus during the later part of what is classically regarded as the absolute refractory period could effectively prolong the absolute refractory period, while leaving the refractory time-constants and other refractory parameters largely unaffected. Indeed, long depolarizing pulses, which would have been suprathreshold if presented to a resting nerve fibre, appeared to block excitation indefinitely. Stimulation during what is classically regarded as the absolute refractory period can therefore greatly affect the temporal response of a nerve. We conclude that the classical definition of absolute refractory period should be refined to include only the initial period following an action potential when an ongoing stimulus would not affect threshold; this period was found to be about half as long as the classical absolute refractory period. We further conclude that the stimulus-dependent nature of the relative refractory period must be considered when developing a phenomenological nerve model for complex stimuli.

  10. Neuroscience in Nazi Europe part I: eugenics, human experimentation, and mass murder.

    Science.gov (United States)

    Zeidman, Lawrence A

    2011-09-01

    The Nazi regime in Germany from 1933 to 1945 waged a veritable war throughout Europe to eliminate neurologic disease from the gene pool. Fueled by eugenic policies on racial hygiene, the Nazis first undertook a sterilization campaign against "mental defectives," which included neurologic patients with epilepsy and other disorders, as well as psychiatric patients. From 1939-41 the Nazis instead resorted to "euthanasia" of many of the same patients. Some neuroscientists were collaborators in this program, using patients for research, or using extracted brains following their murder. Other reviews have focused on Hallervorden, Spatz, Schaltenbrand, Scherer, and Gross, but in this review the focus is on neuroscientists not well described in the neurology literature, including Scholz, Ostertag, Schneider, Nachtsheim, and von Weizsäcker. Only by understanding the actions of neuroscientists during this dark period can we learn from the slippery slope down which they traveled, and prevent history from repeating itself.

  11. Arnold Gesell's progressive vision: child hygiene, socialism and eugenics.

    Science.gov (United States)

    Harris, Ben

    2011-08-01

    In October 1913, The American Magazine published an article by Arnold Gesell that portrayed Alma, Wisconsin (his hometown) as overflowing with the mentally and morally unfit. In "The Village of a Thousand Souls", Gesell called for the observation and segregation of the unfit as a eugenic measure. This article explores the reasons behind this infamous article by someone who became a famous developmental psychologist and pediatrician. Gesell's papers at the Library of Congress reveal his socialist views of poverty, injustice, and human development. The archives of his father's photography studio at the Wisconsin Historical Society reveal his manipulation of the photographic record to fit his negative view of Alma. Typical of the era, Gesell's Progressive vision combined social control and negative eugenics with egalitarianism and the benevolent engineering of the environment.

  12. Disability, gene therapy and eugenics - a challenge to John Harris

    OpenAIRE

    Reindal, S. M.

    2000-01-01

    This article challenges the view of disability presented by Harris in his article, "Is gene therapy a form of eugenics?"1 It is argued that his definition of disability rests on an individual model of disability, where disability is regarded as a product of biological determinism or "personal tragedy" in the individual. Within disability theory this view is often called "the medical model" and it has been criticised for not being able to deal with the term "disability", but only with impairme...

  13. Comparing Eugene P. Wigner, Raymond Duval and Richard P. Feynman

    OpenAIRE

    IURATO, Giuseppe

    2013-01-01

    Inspired by some basic formal aspects of standard model of fundamental physics, in this paper, putting into comparison the Eugene Wigner's theoretical definition of elementary particle with some aspects of the semiotic theory according to Raymond Duval, it will be possible to lay out the former into the latter theory which will get a further epistemological foundation also on the basis of the experimental validations of the standard model itself. Moreover, a final comparison with some epistem...

  14. [Application of case-based method in genetics and eugenics teaching].

    Science.gov (United States)

    Li, Ya-Xuan; Zhao, Xin; Zhang, Fei-Xiong; Hu, Ying-Kao; Yan, Yue-Ming; Cai, Min-Hua; Li, Xiao-Hui

    2012-05-01

    Genetics and Eugenics is a cross-discipline between genetics and eugenics. It is a common curriculum in many Chinese universities. In order to increase the learning interest, we introduced case teaching method and got a better teaching effect. Based on our teaching practices, we summarized some experiences about this subject. In this article, the main problem of case-based method applied in Genetics and Eugenics teaching was discussed.

  15. When the time seems ripe: eugenics, the annals, and the subtle persistence of typological thinking.

    Science.gov (United States)

    Weiss, Kenneth M; Lambert, Brian W

    2011-05-01

    This journal began in 1925 as the Annals of Eugenics. Much has changed since then. The original Editors' primary eugenic objective was not achieved, and eugenics justifiably became notorious for racism and gross abuse of human rights. But one founding aim was to publish advances in statistical genetics, and that objective prospered in the journal's pages from its beginning to the present day. The online availability of the original issues will be useful to those interested in the history of both eugenics and human genetics and will provide a reminder of how the careless use of genetical concepts can go astray.

  16. Energy Edge Post-Occupancy Evaluation Project: The Eugene Water and Electric Board Building (EWEB) Eugene, Oregon

    Energy Technology Data Exchange (ETDEWEB)

    1990-06-01

    The Workspace Satisfaction Survey measures occupant satisfaction with the thermal, lighting, acoustical, and air quality aspects of the work environment. In addition to ratings of these ambient environmental features, occupants also rate their satisfaction with a number of functional and aesthetic features of the office environment as well as their satisfaction with specific kinds of workspaces (e.g., computer rooms, the lobby, employee lounge, etc.) Each section on ambient conditions includes questions on the frequency with which people experience particular kinds of discomforts or problems, how much the discomfort bothers them, and how much it interferes with their work. Occupants are also asked to identify how they cope with discomfort or environmental problems, and to what extent these behaviors enable them to achieve more satisfactory conditions. Results of this survey of occupants of the four story Eugene Water Electric Boards (EWEB) main office building on the banks of the Wilamette River in Eugene, Oregon are the subject of this report.

  17. The "History" of Victorian Scientific Naturalism: Huxley, Spencer and the "End" of natural history.

    Science.gov (United States)

    Lightman, Bernard

    2016-08-01

    As part of their defence of evolutionary theory, T. H. Huxley and Herbert Spencer argued that natural history was no longer a legitimate scientific discipline. They outlined a secularized concept of life from biology to argue for the validity of naturalism. Despite their support for naturalism, they offered two different responses to the decline of natural history. Whereas Huxley emphasized the creation of a biological discipline, and all that that entailed, Spencer was more concerned with constructing an entire intellectual system based on the idea of evolution. In effect, Spencer wanted to create a new scientific worldview based on evolutionary theory. This had consequences for their understanding of human history, especially of how science had evolved through the ages. It affected their conceptions of human agency, contingency, and directionality in history. Examining Huxley's and Spencer's responses to the "end" of natural history reveals some of the deep divisions within scientific naturalism and the inherent problems of naturalism in general. Whereas Huxley chose to separate the natural and the historical, Spencer opted to fuse them into a single system.

  18. A Collocation Method for Numerical Solution of the Generalized Burgers-Huxley Equation

    Directory of Open Access Journals (Sweden)

    Mohammad ZAREBNIA

    2014-08-01

    Full Text Available In this paper, we use a collocation method to solve the Burgers-Huxley equation. To achieve this aim, we use mesh free technique based on sinc functions. The stability analysis is discussed. Some numerical examples are provided to illustrate the accuracy and fluency of the method.

  19. Resonant Activation in a Stochastic Hodgkin-Huxley Model: Interplay between noise and suprathreshold driving effect

    DEFF Research Database (Denmark)

    Pankratova, Evgeniya; Polovinkin, A.V.; Mosekilde, Erik

    2005-01-01

    The paper considers an excitable Hodgkin-Huxley system subjected to a strong periodic forcing in the presence of random noise. The influence of the forcing frequency on the response of the system is examined in the realm of suprathreshold amplitudes. Our results confirm that the presence of noise...

  20. Wilberforce, Huxley and the Use of History in Teaching about Evolution.

    Science.gov (United States)

    Gauld, Colin

    1992-01-01

    Author asserts that many historical anecdotes used in science instruction have little basis in reality. The purpose of this paper is to provide a critique of the way in which the "Wilberforce and Huxley debate at Oxford" anecdote is employed in the teaching of evolution and to suggest a more positive role for this incident in science…

  1. A Cabinet of Mathematical Curiosities at Teachers College: David Eugene Smith's Collection

    Science.gov (United States)

    Murray, Diane R.

    2012-01-01

    This dissertation is a history of David Eugene Smith's collection of historical books, manuscripts, portraits, and instruments related to mathematics. The study analyzes surviving documents, images, objects, college announcements and catalogs, and secondary sources related to Smith's collection. David Eugene Smith (1860-1944) travelled…

  2. Eugenics and education: Implications of ideology, memory, and history for education in the United States

    Science.gov (United States)

    Winfield, Ann Gibson

    Eugenics has been variously described "as an ideal, as a doctrine, as a science (applied human genetics), as a set of practices (ranging from birth control to euthanasia), and as a social movement" (Paul 1998 p. 95). "Race Suicide" (Roosevelt 1905) and the ensuing national phobia regarding the "children of worm eaten stock" (Bobbitt 1909) prefaced an era of eugenic ideology whose influence on education has been largely ignored until recently. Using the concept of collective memory, I examine the eugenics movement, its progressive context, and its influence on the aims, policy and practice of education. Specifically, this study examines the ideology of eugenics as a specific category and set of distinctions, and the role of collective memory in providing the mechanism whereby eugenic ideology may shape and fashion interpretation and action in current educational practice. The formation of education as a distinct academic discipline, the eugenics movement, and the Progressive era coalesced during the first decades of the twentieth century to form what has turned out to be a lasting alliance. This alliance has had a profound impact on public perception of the role of schools, how students are classified and sorted, degrees and definitions of intelligence, attitudes and beliefs surrounding multiculturalism and a host of heretofore unexplored ramifications. My research is primarily historical and theoretical and uses those material and media cultural artifacts generated by the eugenics movement to explore the relationship between eugenic ideology and the institution of education.

  3. Science and Society in the Eugenic Thought of H. J. Muller

    Science.gov (United States)

    Allen, Garland E.

    1970-01-01

    Traces the growth of theories of eugenics during the twentieth century, focussing on the work of H. J. Muller. Concludes that "Muller's lasting contribution was to write the hereditarian attitudes associated with traditional eugenics and the environmentalist's viewpoint associated with modern sociology to obtain a humane and reasoned approach to…

  4. Eugenics, sterilization, and historical memory in the United States.

    Science.gov (United States)

    Stern, Alexandra Minna

    2016-12-01

    From the 1920s to the 1950s, California sterilized approximately 20,000 people in state homes and hospitals based on a eugenic law that authorized medical superintendents to perform reproductive surgeries on patients deemed unfit and "suffering from a mental affliction likely to be inherited." Working with a unique resource - a dataset created from 19,000 sterilization recommendations - my team and I have reconstructed patterns and experiences of institutionalization of sterilizations. This article presents several of our important initial findings related to ethnic and gender bias in sterilization policies, and reflects on the relevance of the history for contemporary issues in genomics and social justice.

  5. The Emergence of Genetic Counseling in Sweden: Examples from Eugenics and Medical Genetics.

    Science.gov (United States)

    Björkman, Maria

    2015-09-01

    This paper examines the intertwined relations between eugenics and medical genetics from a Swedish perspective in the 1940s and 1950s. The Swedish case shows that a rudimentary form of genetic counseling emerged within eugenic practices in the applications of the Swedish Sterilization Act of 1941, here analyzed from the phenomenon of "heredophobia" (ärftlighetsskräck). At the same time genetic counseling also existed outside eugenic practices, within the discipline of medical genetics. The paper argues that a demand for genetic counseling increased in the 1940s and 1950s in response to a sense of reproductive responsibility engendered by earlier eugenic discourse. The paper also questions the claim made by theoreticians of biopolitics that biological citizens have emerged only during the last decades, especially in neoliberal societies. From the Swedish case it is possible to argue that this had already happened earlier in relation to the proliferation of various aspects of eugenics to the public.

  6. Beyond eugenics: the forgotten scandal of hybridizing humans and apes.

    Science.gov (United States)

    Etkind, Alexander

    2008-06-01

    This paper examines the available evidence on one of the most radical ideas in the history of eugenics and utopianism. In the mid-1920s, the zoology professor Ilia Ivanov submitted to the Soviet government a project for hybridizing humans and apes by means of artificial insemination. He received substantial financing and organized expeditions to Africa to catch apes for his experiments. His project caused an international sensation. The American Association for the Advancement of Atheism announced its fund-raising campaign to support Ivanov's project but gave it a scandalously racist interpretation. Ivanov's own motivation remained unclear, as did the motivation of those in the Bolshevik government who supported Ivanov until his arrest in 1930. This paper discusses three hypothetical reasons for Ivanov's adventure: first, hybridization between humans and apes, should it be successful, would support the atheist propaganda of the Bolsheviks; second, regardless of the success of hybridization, Ivanov would catch and bring to Russia apes, which were necessary for the rejuvenation programs that were fashionable among the Bolshevik elite; and third, hybridization, should it be successful, would pave the way to the New Socialist Man whose 'construction by scientific means' was the official purpose of the Bolsheviks. Ivanov's ideas were arguably important for the American proponent of reform eugenics, Herman Muller, and for the Soviet anthropologist Boris Porshnev.

  7. Comparison of Spectral and Differential Quadrature Methods for Solving the Burger-Huxley Equation

    Directory of Open Access Journals (Sweden)

    Jalal Izadian

    2013-06-01

    Full Text Available In this paper, the Burger-Huxley equation is solved by two methods: Spectral method and Differential Quadrature Method (DQM. The Chebyshev-Gauss-Lobatto point distribution is utilized in spectral method. The integrity and computational accuracy of the spectral method in solving some test problems are demonstrated through various case studies. The results show that spectral method is more accurate than DQM.

  8. Development of Galerkin Method for Solving the Generalized Burger's-Huxley Equation

    Directory of Open Access Journals (Sweden)

    M. El-Kady

    2013-01-01

    Full Text Available Numerical treatments for the generalized Burger's—Huxley GBH equation are presented. The treatments are based on cardinal Chebyshev and Legendre basis functions with Galerkin method. Gauss quadrature formula and El-gendi method are used to convert the problem into a system of ordinary differential equations. The numerical results are compared with the literatures to show efficiency of the proposed methods.

  9. Thomas Henry Huxley (1825-1895) puts us in our place.

    Science.gov (United States)

    Weiss, Kenneth M

    2004-05-15

    Thomas Huxley was one of the 19th century's most active defenders of Darwin's idea that life has evolved through natural processes. An anatomist and paleontologist, he extended his energies to science and education policy, the democratization of science, and the broad societal implications of evolution. Since his time the fossil record has greatly improved and the genetic 'revolution' has occurred, deepening our understanding of primate and human evolution in ways that would please Huxley: improved systematics relies heavily on genetic data, and molecular technologies are opening our understanding of the genetic basis of complex traits of traditional anthropological interest-but in ways that are thoroughly dependent on the fact of evolution. A more unified biological synthesis is forming that unites genes, developmental process, structure, and inheritance. But the tempo and mode of evolution remain unresolved. Huxley was one of many who have had trouble accepting Darwin's gradual natural selection as the central evolutionary mechanism, and views spanning the antipodes of gradualism and saltation find advocates even in our genetic era.

  10. SAn Analysis f the theme of “Fard”by Aldous Leonard Huxley

    Institute of Scientific and Technical Information of China (English)

    野长虹

    2014-01-01

    奥德斯�李納�赫胥黎是英格兰作家,著名的赫胥黎家族最杰出的成员之一。赫胥黎是一个人文主义者,和平主义者及讽刺作家。他的文章“胭脂”入选了现代大学英语阅读(4)。此文展示了资产阶级对工人阶级的极度剥削,揭露了资产阶级的丑恶灵魂。本论文旨在分析文章题目揭示的深层次主题。%Leonard Huxley was an English writer and a prominent member of the Huxley family.Huxley was a humanist,pacifist and satirist.His article “Fard”has been elected into the Contemporary College English Reading Book IV.It shows the facts of bourG geoisie’s fierce exploitation to the working class and their ugly souls.This thesis aims at analyzing the deeper theme of the article shown by the title.

  11. Extending the conditions of application of an inversion of the Hodgkin-Huxley gating model.

    Science.gov (United States)

    Raba, Ashley E; Cordeiro, Jonathan M; Antzelevitch, Charles; Beaumont, Jacques

    2013-05-01

    We present an inversion of the Hodgkin-Huxley formalism to estimate initial conditions and model parameters, including functions of voltage, from the solutions of the underlying ordinary differential equation (ODE) subjected to multiple voltage step stimulations. As such, the procedure constitutes a means to estimate the parameters including functions of voltage of an Hodgkin-Huxley formalism from experimental data.The basic idea was developed in a previous communication (SIAM J. Appl. Math. 64:1264-1274, 2009). The inversion in question applies to currents exhibiting activation and inactivation, but the version, as published previously, cannot estimate the unknowns for channels that rapidly inactivate just after a brief opening. In such cases, the amplitude of the current, in a given voltage range, is too small to be detectable by the instrumentation using previously applied experimental protocols. This is, for example, the case for the sodium channels in a number of excitable tissue for potential in the vicinity of the cell resting potential. The current communication extends the inversion procedure in a manner to overcome this limitation.Furthermore, within the inversion framework, we can determine whether the data at the basis of the estimation sufficiently constrains the estimation problem, i.e., whether it is complete. We exploit this element of our method to document a set of stimulation protocols that constitute a complete data set for the purpose of inverting the Hodgkin-Huxley formalism.

  12. Sterilization and birth control in the shadow of eugenics: married, middle-class women in Alberta, 1930-1960s.

    Science.gov (United States)

    Dyck, Erika

    2014-01-01

    The history of eugenic sterilization connotes draconian images of coerced and involuntary procedures robbing men and women of their reproductive health. While eugenics programs often fit this characterization, there is another, smaller, and less obvious legacy of eugenics that arguably contributed to a more empowering image of reproductive health. Sexual sterilization surgeries as a form of contraception began to gather momentum alongside eugenics programs in the middle of the 20th century and experiences among prairie women serve as an illustrative example. Alberta maintained its eugenics program from 1929 to 1972 and engaged in thousands of eugenic sterilizations, but by the 1940s middle-class married women pressured their Albertan physicians to provide them with sterilization surgeries to control fertility, as a matter of choice. The multiple meanings and motivations behind this surgery introduced a moral quandary for physicians, which encourages medical historians to revisit the history of eugenics and its relationship to the contemporaneous birth control movement.

  13. The strength of a loosely defined movement: eugenics and medicine in imperial Russia.

    Science.gov (United States)

    Krementsov, Nikolai

    2015-01-01

    This essay examines the 'infiltration' of eugenics into Russian medical discourse during the formation of the eugenics movement in western Europe and North America in 1900-17. It describes the efforts of two Russian physicians, the bacteriologist and hygienist Nikolai Gamaleia (1859-1949) and the psychiatrist Tikhon Iudin (1879-1949), to introduce eugenics to the Russian medical community, analysing in detail what attracted these representatives of two different medical specialties to eugenic ideas, ideals, and policies advocated by their western colleagues. On the basis of a close examination of the similarities and differences in Gamaleia's and Iudin's attitudes to eugenics, the essay argues that lack of cohesiveness gave the early eugenics movement a unique strength. The loose mix of widely varying ideas, ideals, methods, policies, activities and proposals covered by the umbrella of eugenics offered to a variety of educated professionals in Russia and elsewhere the possibility of choosing, adopting and adapting particular elements to their own national, professional, institutional and disciplinary contexts, interests and agendas.

  14. Confronting the stigma of eugenics: genetics, demography and the problems of population.

    Science.gov (United States)

    Ramsden, Edmund

    2009-12-01

    Building upon the work of Thomas Gieryn and Erving Goffman, this paper will explore how the concepts of stigma and boundary work can be usefully applied to history of population science. Having been closely aligned to eugenics in the early 20th century, from the 1930s both demographers and geneticists began to establish a boundary between their own disciplines and eugenic ideology. The eugenics movement responded to this process of stigmatization. Through strategies defined by Goffman as 'disclosure' and 'concealment', stigma was managed, and a limited space for eugenics was retained in science and policy. Yet by the 1960s, a revitalized eugenics movement was bringing leading social and biological scientists together through the study of the genetic demography of characteristics such as intelligence. The success of this programme of 'stigma transformation' resulted from its ability to allow geneticists and demographers to conceive of eugenic improvement in ways that seemed consistent with the ideals of individuality, diversity and liberty. In doing so, it provided them with an alternative, and a challenge, to more radical and controversial programmes to realize an optimal genotype and population. The processes of stigma attribution and management are, however, ongoing, and since the rise of the nature-nurture controversy in the 1970s, the use of eugenics as a 'stigma symbol' has prevailed.

  15. [Constant or break? On the relations between human genetics and eugenics in the Twentieth Century].

    Science.gov (United States)

    Germann, Pascal

    2015-07-01

    The history of human genetics has been a neglected topic in history of science and medicine for a long time. Only recently, have medical historians begun to pay more attention to the history of human heredity. An important research question deals with the interconnections between human genetics and eugenics. This paper addresses this question: By focusing on a Swiss case study, the investigation of the heredity of goiter, I will argue that there existed close but also ambiguous relations between heredity research and eugenics in the twentieth century. Studies on human heredity often produced evidence that challenged eugenic aims and ideas. Concurrently, however, these studies fostered visions of genetic improvement of human populations.

  16. Eugenics--a side effect of progressivism? analysis of the role of scientific and medical elites in the rise and fall of eugenics in pre-war Poland.

    Science.gov (United States)

    Blach, Olga

    2010-06-01

    The eminent geneticist, Benno Muller-Hill, described eugenics as"explosive mixture between something we might call hard science, that is, human genetics, and the sphere of political action. On the one hand, geneticists needed politicians to implement their ideas. On the other hand, Hitler and the Nazis needed scientists who could say that anti-Semitism has scientific theoretical foundations." For some Polish eugenicists, the Third Reich was not the home of the Nuremberg Laws, but a country that "boldly embarked on racial hygiene." This enthusiastic attitude of Polish intellectual circles towards Nazi eugenic laws was characteristic of the status of pre-war science in Poland, which in many areas, such as anthropology and psychiatry, remained strongly influenced by the paradigm of German science. While the professional and scientific context of the day promoted eugenic and racist ideas within the framework of the academic milieu and the curriculum of the medical and scientific community, eugenicists in Poland tended to refrain from anti-Semitic and racist phraseology. Indeed, the Polish eugenic movement was class- rather than race-orientated. The hybrid language of eugenics, combining social sensitivity with repulsion and contempt for the sick and the weak, illustrated the ambiguous stance of the Polish eugenicists on politics and science in Nazi Germany, for the Third Reich provided the German eugenicists with what had always been an unfulfilled dream to the Polish eugenicists--political power and the ability to implement their ideas.

  17. Eugenics, sterilization, and historical memory in the United States

    Directory of Open Access Journals (Sweden)

    Alexandra Minna Stern

    Full Text Available Abstract From the 1920s to the 1950s, California sterilized approximately 20,000 people in state homes and hospitals based on a eugenic law that authorized medical superintendents to perform reproductive surgeries on patients deemed unfit and “suffering from a mental affliction likely to be inherited.” Working with a unique resource – a dataset created from 19,000 sterilization recommendations – my team and I have reconstructed patterns and experiences of institutionalization of sterilizations. This article presents several of our important initial findings related to ethnic and gender bias in sterilization policies, and reflects on the relevance of the history for contemporary issues in genomics and social justice.

  18. 俄罗斯杀毒大王Eugene Kaspersky

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    现在的病毒越来越厉害,给社会造成的损失也越来越大。但与此同时,这也给防病毒软件企业提供了发展的特续动力。除了赛门铁克、趋势科技等国际性厂商外,还有一个著名的厂商不能不提起,这就是俄罗斯的防毒公司Kaspersky Lab。这家公司的创始人和核心技术研究负责人就是Eugene Kaspersky,他也是俄罗斯软件业的代表人物。

  19. Quality babies. China's "eugenics" guidelines are as old as civilization.

    Science.gov (United States)

    1994-01-12

    Inaccurate translations inadvertently misrepresent policy directives from China. Professional moralizers respond to the new laws with indignation. For example, an editorial in a US newspaper said that Americans objected to China's eugenic guidelines to prevent inferior quality infants. Yet, in the US and other developed countries, parents, and adult siblings do no allow their mentally retarded family members to procreate. Quiet abortions occur. In the US, deformed newborns are classified as stillborns. In the 1950s in the US, state governments allowed sterilization of handicapped people and even alcoholics. The moralizers expect China to accomplish in 10 years what developed countries did in 100 years. China has a one-child policy to which many so-called human rights advocates object. Yet, China cannot sustain a population of 2 billion with the living standards to which it aspires. Granted, however, that China does create its own image problems. It needs to invest more in public relations, maybe employ image-building professionals from the US and Europe to circumvent the unintentional use of emotionally charged, historically loaded, or inappropriate terms and, therefore, to prevent the international media from overreacting. Nevertheless, moral dilemmas do exist with eugenics policies. Genetic markers can detect chromosomal abnormalities leading to mental retardation as well as later-life abnormalities; e.g., colon cancer. Markers may perhaps someday detect a propensity to criminal behavior, homosexuality, or alcoholism. Governments could forbid all genetic testing, resulting in families accepting whatever nature sends, but with the advancement of science, this is unrealistic. If it is banned in one country, people will go to a country where it is available. Since parents in both the US and China want healthy, good-looking and intelligent children US editorialists should not moralize about China while US couples have access to the most up-to-date genetic technology.

  20. Eugenics, sexual pedagogy and social change: constructing the responsible subject of governmentality in the Spanish Second Republic.

    Science.gov (United States)

    Jiménez-Alonso, Belén

    2008-06-01

    This study focuses on eugenics in Spain, and more specifically on the 'official' eugenics whose platform was the Primeras Jornadas Eugénicas Españolas (First Spanish Eugenic Days, FSED). The aim of this paper is to relate eugenics to 'governmentality' rather than to State politics alone and to 'Latin eugenics' rather than to 'mainline eugenics'. On the one hand, the FSED were largely centred on the development of a new sexual code which would set Catholic sexual morality aside. For this reason, sexual pedagogy was one of the most relevant topics during the FSED, personal responsibility becoming the first step to social change. The concern about making people play an active role in their own self-regulation is typical of governmentality. The latter refers to societies where power is decentered and where the objective is to structure the field of action of others (the conduct of conduct). On the other hand, the FSED emphasised preventive eugenics such as welfare programmes and health campaigns rather than negative eugenics such as the sterilisation of the unfit. The situation in Spain was mirrored in countries such as Brazil, Argentina and Mexico, which allows us to think about them in terms of 'Latin eugenics' rather than 'mainline eugenics' from countries such as Great Britain, Germany and the USA.

  1. Eesti aja arhitektuur : Eugen Habermann 125. Herbert Johanson 125 / Ike Volkov

    Index Scriptorium Estoniae

    Volkov, Ike, 1951-

    2010-01-01

    Näitus Eesti Arhitektuurimuuseumis 04. 12. 2009-07. 03. 2010. Eugen Habermannist ja Herbert Johansonist, nende tegevusest ja loomingust. Selle aja ja praegustest probleemidest ning lahendusvõimalustest

  2. Eesti aja arhitektuur : Eugen Habermann 125. Herbert Johanson 125 / Ike Volkov

    Index Scriptorium Estoniae

    Volkov, Ike, 1951-

    2010-01-01

    Näitus Eesti Arhitektuurimuuseumis 04. 12. 2009-07. 03. 2010. Eugen Habermannist ja Herbert Johansonist, nende tegevusest ja loomingust. Selle aja ja praegustest probleemidest ning lahendusvõimalustest

  3. From nation to family: two careers in the recasting of eugenics.

    Science.gov (United States)

    Slavishak, Edward

    2009-01-01

    By examining the professional lives of two popularizers of eugenic thought from the 1910s to the 1940s, this study illustrates the broader change from "mainline" to "reform" eugenics in the United States. Roswell Hill Johnson's university teaching, laboratory research, and later marriage counseling work contrasted greatly with George Seibel's forays into eugenic theater moral reform, and mass physical fitness movements. Yet both men shifted from a strict position of mandating other people's behavior in the name of national health and racial integrity to a more therapeutic stance that cast individual decisions in the context of managed family life. This study shows that for some, the transformation of eugenics in the 1930s meant adapting the traditional focus on superiority, inferiority, and reproduction by design to the language of a commercial marketplace.

  4. An Interview with Dr. Eugene Garfield (Chinese Version)%Eugene Garfield博士访谈(译文)

    Institute of Scientific and Technical Information of China (English)

    任胜利

    2005-01-01

    Eugene Garfield博士是美国著名文献信息检索专家,也是科学引文索引(SCI)之父。关于他的生平及传奇经历,本刊在今年卷首新开辟的“人物”专栏已有详细介绍(见2005年第5卷第1期:79~81)。本文源自对Garfield博士在“A Year of Celebration & Century of Science Launch”的访谈,编者希望能对有志于推进中国科技论文和期刊发展的作者、科技期刊从业者和管理者有所启示。

  5. 一类广义 Burgers-Huxley 方程的解与其分支%Solutions and Its Bifurcation for a Generalized Burgers-Huxley Equation

    Institute of Scientific and Technical Information of China (English)

    王勤龙; 邓习军

    2010-01-01

    运用平面动力系统分支理论和可积性判定方法,研究了一类广义 Burgers-Huxley 方程,首先通过新的算法计算奇点量,解决了其可积性问题,然后进行平衡点类型分析,并讨论了在不同的参数条件下的相图与分支类型,利用 Maple 软件绘出分支相图,最后讨论了各种行波解的存在性及方程的精确解.

  6. Rival Visions: J.J. Rousseau and T.H. Huxley on the Nature (or Nurture) of Inequality and What It Means for Education

    Science.gov (United States)

    Currie-Knight, Kevin

    2011-01-01

    Jean-Jacques Rousseau (1712-1778) and Thomas Huxley (1852-1895) had different, but substantial, effects on the history of education. Rousseau's educational theories supplied the intellectual foundation for pedagogical progressivism. Huxley's educational writings helped to enlarge the scope of the British curriculum to include such things as…

  7. When Harvard said no to eugenics: the J. Ewing Mears Bequest, 1927.

    Science.gov (United States)

    Lombardo, Paul A

    2014-01-01

    James Ewing Mears (1838-1919) was a founding member of the Philadelphia Academy of Surgery. His 1910 book, The Problem of Race Betterment, laid the groundwork for later authors to explore the uses of surgical sterilization as a eugenic measure. Mears left $60,000 in his will to Harvard University to support the teaching of eugenics. Although numerous eugenic activists were on the Harvard faculty, and two of its Presidents were also associated with the eugenics movement, Harvard refused the Mears gift. The bequest was eventually awarded to Jefferson Medical College in Philadelphia. This article explains why Harvard turned its back on a donation that would have supported instruction in a popular subject. Harvard's decision illustrates the range of opinion that existed on the efficacy of eugenic sterilization at the time. The Mears case also highlights a powerful irony: the same week Harvard turned down the Mears legacy, the U.S. Supreme Court endorsed eugenic sterilization in the landmark case of Buck v. Bell. Justice Oliver Wendell Holmes, Jr., graduate of Harvard and former member of its law faculty wrote the opinion in that case, including the famous conclusion: "Three generations of imbeciles are enough."

  8. Eugenic and sexual folklores and the castration of sex offenders in the Netherlands (1938-1968).

    Science.gov (United States)

    van der Meer, Theo

    2008-06-01

    This contribution questions the positive/negative eugenics dichotomy that typifies the historiography on the eugenic movement in the Netherlands and the claim that this movement was mostly marginal because only positive eugenics was pursued. From 1938 to 1968 in the Netherlands, after a decade of debates, 400 sex offenders who had been committed to asylums for the criminally insane were 'voluntarily' and 'therapeutically' castrated. For political reasons debates on castration, meant to create consensus, eliminated any reference to or connotation with eugenics, yet these policies were unthinkable without them. This article shows that thinking about social and sexual problems and their solutions in the 1930s were permeated by eugenic folklore which in turn was informed by sexual folklore. Both eugenic and sexual lore, as common sense, or as ways of knowing, were about individual and collective loss of self control which was referred to with a catch-all phrase: 'hypersexuality'. Although sexual classifications used in diagnosing sex offenders suggested the existence of discrete sexual categories, homosexuality for instance was not seen as a sexual alternative or as an identity but as the extent to which an offender suffered from a form of hypersexuality that threatened the fabric of society.

  9. Channel noise effects on first spike latency of a stochastic Hodgkin-Huxley neuron

    Science.gov (United States)

    Maisel, Brenton; Lindenberg, Katja

    2017-02-01

    While it is widely accepted that information is encoded in neurons via action potentials or spikes, it is far less understood what specific features of spiking contain encoded information. Experimental evidence has suggested that the timing of the first spike may be an energy-efficient coding mechanism that contains more neural information than subsequent spikes. Therefore, the biophysical features of neurons that underlie response latency are of considerable interest. Here we examine the effects of channel noise on the first spike latency of a Hodgkin-Huxley neuron receiving random input from many other neurons. Because the principal feature of a Hodgkin-Huxley neuron is the stochastic opening and closing of channels, the fluctuations in the number of open channels lead to fluctuations in the membrane voltage and modify the timing of the first spike. Our results show that when a neuron has a larger number of channels, (i) the occurrence of the first spike is delayed and (ii) the variation in the first spike timing is greater. We also show that the mean, median, and interquartile range of first spike latency can be accurately predicted from a simple linear regression by knowing only the number of channels in the neuron and the rate at which presynaptic neurons fire, but the standard deviation (i.e., neuronal jitter) cannot be predicted using only this information. We then compare our results to another commonly used stochastic Hodgkin-Huxley model and show that the more commonly used model overstates the first spike latency but can predict the standard deviation of first spike latencies accurately. We end by suggesting a more suitable definition for the neuronal jitter based upon our simulations and comparison of the two models.

  10. Eugenics discourse and racial improvement in Republican China (1911-1949).

    Science.gov (United States)

    Sihn, Kyu-hwan

    2010-12-31

    This paper aimed to examine the advent of eugenics and its characteristics in republican China. Although eugenics was introduced into China as a discourse to preserve and improve race by the 1898 reformers such as Yan Fu (1854-1921) and Yi Nai (1875-?) in the late imperial period, it was not until the republican period that eugenics discourse started to combine with the discourse and movement related to social reform. The May 4th intellectuals put forward criticisms of Confucian patriarchy, propagating science and democracy. They pointed out that the large family system was a source of every social evil, and argued the need for a small family system based on monogamy. The aim of the small family system was to improve both the race and the environment. Such thinkers argued that freedom of love and the liberation of individuality were necessary for this end. Zhou Jianren (1888-1984), Lu Xun's youngest brother and representative eugenicist in the May 4th period, combined eugenics with freedom of love and the liberation of individuality. Pan Guangdan (1899-1967) and Zhou Jianren debated the eugenics controversy in the 1920s. They raised the freedom of love and the liberation of individuality as central issues related to the eugenics controversy. The eugenics debate was developed into the controversy between biological determinism and environmentalism in the late 1920s. However, these issues did not continue to be brought up in the 1930s. The main issues concerning the eugenics controversy in the 1930s were cultural identity and the population problem. Particularly in the 1930s, the scope of birth control as the solution to the population problem was extended from the individual person and family to nation and race. For eugenicists like Pan Guangdan, birth control violated the aim of eugenics and brought about the degeneration of the race. However, such theorists did not deny the value of birth control itself. The supporters of birth control thought that selecting

  11. The meaning of eugenics: reflections on the government of genetic knowledge in the past and the present.

    Science.gov (United States)

    Koch, Lene

    2004-09-01

    The recent development of molecular genetics has created concern that society may experience a new eugenics. Notions about eugenics and what took place in the 1930s and 1940s are actively shaping questions about which uses of new genetics should be considered illegitimate. Drawing upon a body of historiographical literature on Scandinavian eugenics, this paper argues that the dominant view of eugenics as morally and scientifically illegitimate is not tenable when it comes to the uses of compulsion, political motivation, and scientific acceptability. In spite of a general condemnation of eugenics, health authorities today are trying to prevent individuals with deviant behavior from reproducing or at least from rearing children. This may not be argued with reference to the risk of transmitting defective genes, but rather the risk of producing undesirable social problems. Drawing on a Foucauldian approach, the paper concludes that eugenics and new genetics should be seen as two historically specific forms of biopower.

  12. The neuron physiology and Hodgkin-Huxley and FitzHugh-Nagumo models

    OpenAIRE

    2007-01-01

    Resumo: Apresentaremos neste trabalho descrições detalhadas da modelagem e conceitos fisiológicos associados aos modelos de Hodgkin-Huxley e Fitzhugh-Nagumo, para em seguida compararmos suas características. Tentaremos justificar a opção pelo modelo de Fitzhugh-Nagumo como objeto de estudo viável pra interações entre neurônios, e em seguida introduziremos um tipo de interação na qual o comportamento do sistema para dois neurônios apresenta fenômenos de comportamento irregular. Para isso, most...

  13. Thermal impact on spiking properties in Hodgkin-Huxley neuron with synaptic stimulus

    Indian Academy of Sciences (India)

    Shenbing Kuang; Jiafu Wang; Ting Zeng; Aiyin Cao

    2008-01-01

    The effect of environmental temperature on neuronal spiking behaviors is investigated by numerically simulating the temperature dependence of spiking threshold of the Hodgkin-Huxley neuron subject to synaptic stimulus. We find that the spiking threshold exhibits a global minimum in a specific temperature range where spike initiation needs weakest synaptic strength, which form the engineering perspective indicates the occurrence of optimal use of synaptic transmission in the nervous system. We further explore the biophysical origin of this phenomenon associated with ion channel gating kinetics and also discuss its possible biological relevance in information processing in neuronal systems.

  14. Non-Gaussian Colored Noise Optimized Spatial Coherence of a Hodgkin—Huxley Neuronal Network

    Science.gov (United States)

    Sun, Xiao-Juan; Lu, Qi-Shao

    2014-02-01

    We numerically study how non-Gaussian colored noise affects the spatial coherence of a Hodgkin—Huxley neuronal network. From the simulation results, we find that there exists some intermediate noise intensities, correlation time of the colored noise, and the deviation from Gaussian colored noise, for which an ordered pattern with a characteristic spatial frequency of the system comes forth in a resonant manner. Namely, under certain conditions, spatial coherence of the studied neuronal network can be optimized by the non-Gaussian colored noise, which indicates the occurrence of spatial coherence resonance.

  15. Unidirectional synchronization of Hodgkin-Huxley neurons exposed to ELF electric field

    Energy Technology Data Exchange (ETDEWEB)

    Wang Jiang [School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072 (China)], E-mail: jiangwang@tju.edu.cn; Che Yanqiu; Zhou Sisi; Deng Bin [School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072 (China)

    2009-02-15

    In this paper, a hybrid control strategy, H{sub {infinity}} variable universe adaptive fuzzy control, is derived and applied to synchronize two Hodgkin-Huxley (HH) neurons exposed to external electric field. Firstly, the modified model of HH neuron exposed to extremely low frequency (ELF) external electric field is established and its periodic and chaotic dynamics in response to sinusoidal electric field stimulation are described. And then the statement of the problem for unidirectional synchronization of two HH neurons is given. Finally H{sub {infinity}} variable universe adaptive fuzzy control is designed to synchronize the HH systems and the simulation results demonstrate the effectiveness of the proposed control method.

  16. Responses of Hodgkin-Huxley Neuronal Systems to Spike-Train Inputs

    Institute of Scientific and Technical Information of China (English)

    CHANG Wen-Li; WANG Sheng-Jun; WANG Ying-Hai

    2007-01-01

    We investigate responses of the Hodgkin-Huxley globally neuronal systems to periodic spike-train inputs. The firing activities of the neuronal networks show different rhythmic patterns for different parameters. These rhythmic patterns can be used to explain cycles of firing in real brain. These activity patterns, average activity and coherence measure are affected by two quantities such as the percentage of excitatory couplings and stimulus intensity, in which the percentage of excitatory couplings is more important than stimulus intensity since the transition phenomenon of average activity comes about.

  17. Synchronization of a coupled Hodgkin-Huxley neurons via high order sliding-mode feedback

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar-Lopez, R. [Division de Ciencias Basicas e Ingenieria, Universidad Autonoma Metropolitana, Av. San Pablo No. 180, Reynosa-Tamaulipas, 02200 Azcapotzalco, Mexico, D.F. (Mexico)], E-mail: raguilar@correo.azc.uam.mx; Martinez-Guerra, R. [Departamento de Control Automatico, CINVESTAV-IPN, Apartado Postal 14-740, Mexico, D.F. C.P. 07360 (Mexico)], E-mail: rguerra@ctrl.cinvestav.mx

    2008-07-15

    This work deals with the synchronizations of two both coupled Hodgkin-Huxley (H-H) neurons, where the master neuron posses inner noise and the slave neuron is considered in a resting state, (without inner noise) and an exciting state (with inner noise). The synchronization procedure is done via a feedback control, considering a class of high order sliding-mode controller which provides chattering reduction and finite time synchronization convergence, with a satisfactory performance. Theoretical analysis is done in order to show the closed-loop stability of the proposed controller and the calculated finite time for convergence. The main results are illustrated via numerical experiments.

  18. Soliton-like solutions to the generalized Burgers-Huxley equation with variable coefficients

    Science.gov (United States)

    Triki, Houria; Wazwaz, Abdul-Majid

    2013-12-01

    In this paper, we consider the generalized Burgers-Huxley equation with arbitrary power of nonlinearity and timedependent coefficients. We analyze the traveling wave problem and explicitly find new soliton-like solutions for this extended equation by using the ansatz of Zhao et al. [X. Zhao, D. Tang, L. Wang, Phys. Lett. A 346 (2005) 288-291]. We also employ the solitary wave ansatz method to derive the exact bright and dark soliton solutions for the considered evolution equation. The physical parameters in the soliton solutions are obtained as function of the time-dependent model coefficients. The conditions of existence of solitons are presented. As a result, rich exact travelling wave solutions, which contain new soliton-like solutions, bell-shaped solitons and kink-shaped solitons for the generalized Burgers-Huxley equation with time-dependent coefficients, are obtained. The methods employed here can also be used to solve a large class of nonlinear evolution equations with variable coefficients.

  19. Spiking sychronization regulated by noise in three types of Hodgkin-Huxley neuronal networks

    Institute of Scientific and Technical Information of China (English)

    Zhang Zheng-Zhen; Zeng Shang-You; Tang Wen-Yan; Hu Jin-Lin; Zeng Shao-Wen; Ning Wei-Lian; Qiu Yi; Wu Hui-Si

    2012-01-01

    In this paper,we study spiking synchronization in three different types of Hodgkin-Huxley neuronal networks,which are the small-world,regular,and random neuronal networks. All the neurons are subjected to subthreshold stimulus and external noise. It is found that in each of all the neuronal networks there is an optimal strength of noise to induce the maximal spiking synchronization.We further demonstrate that in each of the neuronal networks there is a range of synaptic conductance to induce the effect that an optimal strength of noise maximizes the spiking synchronization.Only when the magnitude of the synaptic conductance is moderate,will the effect be considerable.However,if the synaptic conductance is small or large,the effect vanishes.As the connections between neurons increase,the synaptic conductance to maximize the effect decreases.Therefore,we show quantitatively that the noise-induced maximal synchronization in the Hodgkin-Huxley neuronal network is a general effect,regardless of the specific type of neuronal network.

  20. Eugene F. Fama: Nobel prize for 2013: Capital market efficiency

    Directory of Open Access Journals (Sweden)

    Pantelić Svetlana

    2015-01-01

    Full Text Available In 2013 the Nobel Prize in Economic Sciences was awarded to the American economists, Eugene Fama, Lars Peter Hansen and Robert Shiller. The monetarists, Fama and Hansen, from the University of Chicago, and the Neo- Keynesian, Shiller, from the Yale University, according to the Swedish Royal Academy, won this prestigious prize for their research providing mathematical and economic models to determine (irregularities in the stock value trends at the stock exchanges. With his colleagues, in the 1960s Fama established that, in the short term, it is extremely difficult to forecast stock prices, given that new information gets embedded in the prices rather quickly. Shiller, however, determined that, although it is almost impossible to predict the stock prices for a period of few days, this is not true for a period of several years. He discovered that the stock prices fluctuate much more substantially than corporation dividents, and that the relationship between prices and dividends tends to decline when high, and to grow when low. This pattern does not apply only to stocks, but also to bonds and other forms of capital.

  1. [Neurocosmetics, transhumanism and eliminative materialism: toward new ways of eugenics].

    Science.gov (United States)

    Echarte Alonso, Luis E

    2012-01-01

    In this paper I present similarities and connections between Transhumanism and Eliminative Materialism. Concretely, I study the arguments with which in both positions it is defended a merely instrumental idea of human body and, because of that, one infinitely mouldable. First, I show the social relevance of this idea and its projections in phenomena as medicalization of human condition and, especially, cosmetic psychopharmacology. Besides, I denounce that such influences are caused by illegitimate transference of authority between philosophical and scientific forums. Second, according to my analysis, these new postmodern fashions of chemical sentimentalism (related with radical changes on personal identity and human nature) drive to new eugenic forms what I name autoeugenics. Finally, I call attention to the important role of utopian speeches about the science of tomorrow and super-human civilization in a Carpe Diem society. In my conclusions, I claim that historical reasoning or warnings about what is coming are not efficient strategies to control neither new psychopharmacological habits nor passivity generated by them. Returning social confidence in the power of reason to achieve reality (and other human beings) is, in my opinion, the best way to rehabilitate a more and more devalued human action.

  2. Karl Pearson and eugenics: personal opinions and scientific rigor.

    Science.gov (United States)

    Delzell, Darcie A P; Poliak, Cathy D

    2013-09-01

    The influence of personal opinions and biases on scientific conclusions is a threat to the advancement of knowledge. Expertise and experience does not render one immune to this temptation. In this work, one of the founding fathers of statistics, Karl Pearson, is used as an illustration of how even the most talented among us can produce misleading results when inferences are made without caution or reference to potential bias and other analysis limitations. A study performed by Pearson on British Jewish schoolchildren is examined in light of ethical and professional statistical practice. The methodology used and inferences made by Pearson and his coauthor are sometimes questionable and offer insight into how Pearson's support of eugenics and his own British nationalism could have potentially influenced his often careless and far-fetched inferences. A short background into Pearson's work and beliefs is provided, along with an in-depth examination of the authors' overall experimental design and statistical practices. In addition, portions of the study regarding intelligence and tuberculosis are discussed in more detail, along with historical reactions to their work.

  3. From eugenics to scientometrics: Galton, Cattell, and men of science.

    Science.gov (United States)

    Godin, Benoît

    2007-10-01

    In 1906, James McKeen Cattell, editor of Science, published a directory of men of science. American Men of Science was a collection of biographical sketches of thousands of men of science in the USA and was published periodically. It launched, and was used in, the very first systematic quantitative studies on science. Cattell used two concepts for his statistics: productivity, defined as the number of men of science a nation produces, and performance or merit, defined as scientific contributions to research as judged by peers. These are the two dimensions that still define measurement of scientific productivity today: quantity and quality. This paper analyzes the emergence of statistics on science and the very first uses to which they were put. It argues that the measurement of science emerged out of interest in great men, heredity and eugenics, and the contribution of eminent men to civilization. Among these eminent men were men of science, the population of whom was thought to be in decline and insufficiently appreciated and supported. Statistics on men of science thus came to be collected to document the case, and to contribute to the advancement of science and the scientific profession.

  4. Hugh E. Huxley: cambiando el paradigma de la contracción muscular, desde dentro. [Hugh E. Huxley: changing from inside the paradigm of muscle contraction].

    Directory of Open Access Journals (Sweden)

    Adolfo Araci

    2014-04-01

    Full Text Available Desde un punto de vista físico se puede entender la fibra muscular como un motor, es decir, un sistema capaz de transformar la energía química en energía mecánica, que se utiliza para realizar un trabajo. Por lo tanto, para entender cómo ocurre dicho proceso de transformación es necesario conocer la ultraestructura de la fibra muscular. Esta es, sin duda, la principal aportación al acervo científico del recientemente fallecido Hugh Emor Huxley (1924-2013. Huxley se graduó en Física en el Christ’s College de Cambdrige, tras ver interrumpidos temporalmente sus estudios por su dedicación como operario de radar de la Royal Air Force entre 1943 y 1947, durante la Segunda Guerra Mundial (Pollard y Goldman, 2013; Spudich, 2013. Tras su graduación se incorporó como el primer estudiante de doctorado a una unidad de nueva creación del Medical Research Council, el “Laboratorio de Biología Molecular”, dirigida por Max Perutz y John Kendrew, siendo este último el director de sus tesis doctoral, que fue defendida en 1952 (Spudich, 2013. El uso de la técnicas de difracción de rayos X, que permitían el estudio en niveles de resolución inalcanzables con las técnicas microscópicas del momento, y su aplicación a la descripción de la ultraestructura muscular, fueron el objeto de su tesis doctoral, para el desarrollo de la cual diseñó y construyó sus propios instrumentos. El esclarecimiento de los aspectos estructurales implicados en la contracción muscular se convirtió desde entonces en la pregunta central de su biografía científica.

  5. Eugenics, politics and the state: social democracy and the Swiss 'gardening state'.

    Science.gov (United States)

    Mottier, Véronique

    2008-06-01

    This article explores the connections between eugenics, politics and the state, taking the Swiss case as a particular focus. It is argued that Switzerland provides a historical example of what Bauman [Bauman, Z. (1989). Modernity and the Holocaust. Cambridge: Polity Press.] describes as 'gardening states': states that are concerned with eliminating the 'bad weeds' from the national garden and thereby constructing sharply exclusionary national identities. The Swiss experiments with eugenics (1920s-1960s) can be seen as an example of an ongoing struggle against 'difference'. Against this backdrop I will examine, first, the ways in which state regulation of reproductive sexuality, and other eugenic measures, became central mechanisms for dealing with cultural and other 'differences' in the Swiss nation. Second, I will analyse the gendered nature of such mechanisms, as well as the preoccupation with racial 'difference' exemplified by eugenic policies towards 'Gypsies'. To conclude, I will examine the impact of political institutions and political ideology, in particular, social democracy, on these eugenic gardening efforts.

  6. From 'beastly philosophy' to medical genetics: eugenics in Russia and the Soviet Union.

    Science.gov (United States)

    Krementsov, Nikolai

    2011-01-01

    This essay offers an overview of the three distinct periods in the development of Russian eugenics: Imperial (1900-1917), Bolshevik (1917-1929), and Stalinist (1930-1939). Began during the Imperial era as a particular discourse on the issues of human heredity, diversity, and evolution, in the early years of the Bolshevik rule eugenics was quickly institutionalized as a scientific discipline--complete with societies, research establishments, and periodicals--that aspired an extensive grassroots following, generated lively public debates, and exerted considerable influence on a range of medical, public health, and social policies. In the late 1920s, in the wake of Joseph Stalin's 'Great Break', eugenics came under intense critique as a 'bourgeois' science and its proponents quickly reconstituted their enterprise as 'medical genetics'. Yet, after a brief period of rapid growth during the early 1930s, medical genetics was dismantled as a 'fascist science' towards the end of the decade. Based on published and original research, this essay examines the factors that account for such an unusual--as compared to the development of eugenics in other locales during the same period--historical trajectory of Russian eugenics.

  7. Eugenics from the New Deal to the Great Society: genetics, demography and population quality.

    Science.gov (United States)

    Ramsden, Edmund

    2008-12-01

    The relationship between biological and social scientists as regards the study of human traits and behavior has often been perceived in terms of mutual distrust, even antipathy. In the interwar period, population study seemed an area that might allow for closer relations between them-united as they were by a concern to improve the eugenic quality of populations. Yet these relations were in tension: by the early post-war era, social demographers were denigrating the contributions of biologists to the study of population problems as embodying the elitist ideology of eugenics. In response to this loss of credibility, the eugenics movement pursued a simultaneous program of withdrawal and expansion: its leaders helped focus concern with biological quality onto the developing field of medical genetics, while at the same moment, extended their scope to improving the social quality of populations through birth control policies, guided by demography. While this approach maintained boundaries between the social and the biological, in the 1960s, a revitalized American Eugenics Society helped reunite leading demographers and geneticists. This paper will assess the reasons for this period of influence for eugenics, and explore its implications for the social and biological study of human populations.

  8. Prenatal diagnosis as a tool and support for eugenics: myth or reality in contemporary French society?

    Science.gov (United States)

    Gaille, Marie; Viot, Géraldine

    2013-02-01

    Today, French public debate and bioethics research reflect an ongoing controversy about eugenics. The field of reproductive medicine is often targeted as pre-implantation genetic diagnosis (PGD), prenatal diagnosis, and prenatal detection are accused of drifting towards eugenics or being driven by eugenics considerations. This article aims at understanding why the charge against eugenics came at the forefront of the ethical debate. Above all, it aims at showing that the charge against prenatal diagnosis is groundless. The point of view presented in this article has been elaborated jointly by a geneticist and a philosopher. Besides a survey of the medical, bioethical, philosophical and social sciences literature on the topic, the methodology is founded on a joint analysis of geneticist's various consults. Evidence from office visits demonstrated that prenatal diagnosis leads to case-by-case decisions. As we have suggested, this conclusion does not mean that prenatal diagnosis is devoid of ethical issues, and we have identified at least two. The first is related to the evaluation of a decision to abort. The second line of ethical questions arises from the fact that the claim for "normality" hardly hides normative and ambiguous views about disability. As a conclusion, ethical dilemmas keep being noticeable in the field of reproductive medicine and genetic counselling, but an enquiry about eugenic tendencies probably does not allow us to understand them in the proper way.

  9. Emancipation through interaction--how eugenics and statistics converged and diverged.

    Science.gov (United States)

    Louçã, Francisco

    2009-01-01

    The paper discusses the scope and influence of eugenics in defining the scientific programme of statistics and the impact of the evolution of biology on social scientists. It argues that eugenics was instrumental in providing a bridge between sciences, and therefore created both the impulse and the institutions necessary for the birth of modern statistics in its applications first to biology and then to the social sciences. Looking at the question from the point of view of the history of statistics and the social sciences, and mostly concentrating on evidence from the British debates, the paper discusses how these disciplines became emancipated from eugenics precisely because of the inspiration of biology. It also relates how social scientists were fascinated and perplexed by the innovations taking place in statistical theory and practice.

  10. Medicine, eugenics, and the Supreme Court: from coercive sterilization to reproductive freedom.

    Science.gov (United States)

    Lombardo, P A

    1996-01-01

    This article shows how the current language of reproductive rights, including the determination of US constitutional protections, can be traced to three cases heard by the US Supreme Court that challenged eugenic state legislation written between 1924 and 1935. The introduction defines "eugenics" as the notion that the human race can be improved and social ills gradually eliminated by selective procreation and notes that eugenicists were extremely effective in using the law as their ally and effected the adoption of nearly 100 eugenic statutes by the states between 1900 and 1970. Part 2 examines the classification of social deviance as a social ill that could be overcome by the application of eugenic principles bolstered by scientific explanations about defective "germ-plasm." The third part of the article illustrates the legal impact of US eugenicists in 1924 when the Federal Immigration Restriction Act was adopted with national origin quotas that remained in place until 1965. This year also saw adoption of two eugenic laws enacted in Virginia that would be later challenged in the Supreme Court. Part 4 details one of these cases, Buck vs. Bell, that challenged Virginia's Eugenical Sterilization Act. In upholding the Virginia statute, the Supreme Court allowed the forced sterilization of a young woman in the first and only instance in which the Court allowed a physician to act as an agent of state government in the performance of an undesired and unnecessary operation. Part 5 describes how the Supreme Court overturned Oklahoma's law mandating the sterilization of "hereditary criminals" in Skinner vs. Oklahoma. The 1967 ruling in Loving vs. Virginia overturning Virginia's Racial Integrity Act preventing interracial marriage is presented in part 6. The article ends by tracing the impact of these cases on the constitutionalization of reproductive rights in the US.

  11. Homoclinic bifurcation in a Hodgkin-Huxley model of thermally sensitive neurons

    Energy Technology Data Exchange (ETDEWEB)

    Feudel, Ulrike [Department of Physics, University of Potsdam, Potsdam 14415, (Germany); Neiman, Alexander [Center for Neurodynamics, University of Missouri at St. Louis, St. Louis, Missouri 63121 (United States); Pei, Xing [Center for Neurodynamics, University of Missouri at St. Louis, St. Louis, Missouri 63121 (United States); Wojtenek, Winfried [Center for Neurodynamics, University of Missouri at St. Louis, St. Louis, Missouri 63121 (United States); Braun, Hans [Institute of Physiology, University of Marburg, Marburg 35037, (Germany); Huber, Martin [Institute of Physiology, University of Marburg, Marburg 35037, (Germany); Moss, Frank [Center for Neurodynamics, University of Missouri at St. Louis, St. Louis, Missouri 63121 (United States)

    2000-03-01

    We study global bifurcations of the chaotic attractor in a modified Hodgkin-Huxley model of thermally sensitive neurons. The control parameter for this model is the temperature. The chaotic behavior is realized over a wide range of temperatures and is visualized using interspike intervals. We observe an abrupt increase of the interspike intervals in a certain temperature region. We identify this as a homoclinic bifurcation of a saddle-focus fixed point which is embedded in the chaotic attractors. The transition is accompanied by intermittency, which obeys a universal scaling law for the average length of trajectory segments exhibiting only short interspike intervals with the distance from the onset of intermittency. We also present experimental results of interspike interval measurements taken from the crayfish caudal photoreceptor, which qualitatively demonstrate the same bifurcation structure. (c) 2000 American Institute of Physics.

  12. Strange Nonchaotic Oscillations in The Quasiperiodically Forced Hodgkin-Huxley Neuron

    CERN Document Server

    Lim, Woochang; 10.1088/1751-8113/42/26/265103

    2011-01-01

    We numerically study dynamical behaviors of the quasiperiodically forced Hodgkin-Huxley neuron and compare the dynamical responses with those for the case of periodic stimulus. In the periodically forced case, a transition from a periodic to a chaotic oscillation was found to occur via period doublings in previous numerical and experimental works. We investigate the effect of the quasiperiodic forcing on this period-doubling route to chaotic oscillation. In contrast to the case of periodic forcing, new type of strange nonchaotic (SN) oscillating states (that are geometrically strange but have no positive Lyapunov exponents) are found to exist between the regular and chaotic oscillating states as intermediate ones. Their strange fractal geometry leads to aperiodic "complex" spikings. Various dynamical routes to SN oscillations are identified, as in the quasiperiodically forced logistic map. These SN spikings are expected to be observed in experiments of the quasiperiodically forced squid giant axon.

  13. A correspondence between the models of Hodgkin-Huxley and FitzHugh-Nagumo revisited

    Science.gov (United States)

    Postnikov, Eugene B.; Titkova, Olga V.

    2016-11-01

    We present the discussion on the possibility to scale the classical dimensionless FitzHugh-Nagumo model of neuronal self-sustained oscillations to the range of variables corresponding to the results, which are provided by the biophysically relevant reduced two-dimensional Hodgkin-Huxley equations (the Rinzel model). It is shown that there exists a relatively simple choice of affine transformation, which results in time-dependent solutions, which reproduce with a high accuracy the time course of the recovery variable and the sharp onsets (intervals of fast motions on a phase trajectories) of the voltage spikes. As for the latter, the reasons for unavoidable difference are discussed as well as a necessity of taking into account applied current values during such a scaling procedure.

  14. Identifying generalized Fitzhugh-Nagumo equation from a numerical solution of Hodgkin-Huxley model

    Directory of Open Access Journals (Sweden)

    Nikola V. Georgiev

    2003-01-01

    Full Text Available An analytic time series in the form of numerical solution (in an appropriate finite time interval of the Hodgkin-Huxley current clamped (HHCC system of four differential equations, well known in the neurophysiology as an exact empirical model of excitation of a giant axon of Loligo, is presented. Then we search for a second-order differential equation of generalized Fitzhugh-Nagumo (GFN type, having as a solution the given single component (action potential of the numerical solution. The given time series is used as a basis for reconstructing orders, powers, and coefficients of the polynomial right-hand sides of GFN equation approximately governing the process of action potential. For this purpose, a new geometrical method for determining phase space dimension of the unknown dynamical system (GFN equation and a specific modification of least squares method for identifying unknown coefficients are developed and applied.

  15. Temperature Effects on Information Capacity and Energy Efficiency of Hodgkin-Huxley Neuron

    CERN Document Server

    Wang, Long-Fei; Liu, Xiao-Zhi; Song, Ya-lei; Yu, Lian-Chun

    2015-01-01

    Recent experimental and theoretical studies show that energy efficiency, which measures the amount of information processed by a neuron with per unit of energy consumption, plays an important role in the evolution of neural systems. Here, we calculated the information rates and energy efficiencies of the Hodgkin-Huxley (HH) neuron model at different temperatures in a noisy environment. We found that both the information rate and energy efficiency are maximized by certain temperatures. Though the information rate and energy efficiency cannot be maximized simultaneously, the neuron holds a high information processing capacity at the temperature corresponding to maximal energy efficiency. Our results support the idea that the energy efficiency is a selective pressure that influences the evolution of nervous systems.

  16. In-phase and anti-phase synchronization in noisy Hodgkin-Huxley neurons

    CERN Document Server

    Schmid, Gerhard; Hanggi, Peter

    2013-01-01

    We numerically investigate the influence of intrinsic channel noise on the dynamical response of delay-coupling in neuronal systems. The stochastic dynamics of the spiking is modeled within a stochastic modification of the standard Hodgkin-Huxley model wherein the delay-coupling accounts for the finite propagation time of an action potential along the neuronal axon. We quantify this delay-coupling of the Pyragas-type in terms of the difference between corresponding presynaptic and postsynaptic membrane potentials. In case of a single neuron we analyze the spiking activity in presence of an autaptic feedback loop. With vanishing channel noise the interspike interval increases with increasing delay time. For an elementary neuronal network consisting of two coupled neurons we detect characteristic stochastic synchronization patterns which exhibit multiple phase-flip bifurcations: The phase-flip bifurcations occur in form of alternate transitions from an in-phase spiking activity towards an anti-phase spiking act...

  17. Spike trains in Hodgkin-Huxley model and ISIs of acupuncture manipulations

    Energy Technology Data Exchange (ETDEWEB)

    Wang Jiang [School of Electrical and Automation Engineering, Tianjin University, Tianjin 300072 (China)], E-mail: jiangwang@tju.edu.cn; Si Wenjie; Che Yanqiu; Fei Xiangyang [School of Electrical and Automation Engineering, Tianjin University, Tianjin 300072 (China)

    2008-05-15

    The Hodgkin-Huxley equations (HH) are parameterized by a number of parameters and shows a variety of qualitatively different behaviors depending on the parameter values. Under stimulation of an external periodic voltage, the ISIs (interspike intervals) of a HH model are investigated in this work, while the frequency of the voltage is taken as the controlling parameter. As well-known, the science of acupuncture and moxibustion is an important component of Traditional Chinese Medicine with a long history. Although there are a number of different acupuncture manipulations, the method for distinguishing them is rarely investigated. With the idea of ISI, we study the electrical signal time series at the spinal dorsal horn produced by three different acupuncture manipulations in Zusanli point and present an effective way to distinguish them.

  18. Emergent Central Pattern Generator Behavior in Gap-Junction-Coupled Hodgkin-Huxley Style Neuron Model

    Directory of Open Access Journals (Sweden)

    Kyle G. Horn

    2012-01-01

    Full Text Available Most models of central pattern generators (CPGs involve two distinct nuclei mutually inhibiting one another via synapses. Here, we present a single-nucleus model of biologically realistic Hodgkin-Huxley neurons with random gap junction coupling. Despite no explicit division of neurons into two groups, we observe a spontaneous division of neurons into two distinct firing groups. In addition, we also demonstrate this phenomenon in a simplified version of the model, highlighting the importance of afterhyperpolarization currents ( to CPGs utilizing gap junction coupling. The properties of these CPGs also appear sensitive to gap junction conductance, probability of gap junction coupling between cells, topology of gap junction coupling, and, to a lesser extent, input current into our simulated nucleus.

  19. Strange nonchaotic oscillations in the quasiperiodically forced Hodgkin-Huxley neuron

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Woochang; Kim, Sang-Yoon [Department of Physics, Kangwon National University, Chunchon, Kangwon-Do 200-701 (Korea, Republic of)], E-mail: wclim@kangwon.ac.kr, E-mail: sykim@kangwon.ac.kr

    2009-07-03

    We numerically study dynamical behaviors of the quasiperiodically forced Hodgkin-Huxley neuron and compare the dynamical responses with those for the case of periodic stimulus. In the periodically forced case, a transition from a periodic to a chaotic oscillation was found to occur via period doublings in previous numerical and experimental works. We investigate the effect of the quasiperiodic forcing on this period-doubling route to chaotic oscillation. In contrast to the case of periodic forcing, a new type of strange nonchaotic (SN) oscillating states (that are geometrically strange but have no positive Lyapunov exponents) is found to exist between the regular and chaotic oscillating states as intermediate ones. Their strange fractal geometry leads to aperiodic 'complex' spikings. Various dynamical routes to SN oscillations are identified, as in the quasiperiodically forced logistic map. These SN spikings are expected to be observed in experiments of the quasiperiodically forced squid giant axon.

  20. Dynamic range in small-world networks of Hodgkin-Huxley neurons with chemical synapses

    Science.gov (United States)

    Batista, C. A. S.; Viana, R. L.; Lopes, S. R.; Batista, A. M.

    2014-09-01

    According to Stevens' law the relationship between stimulus and response is a power-law within an interval called the dynamic range. The dynamic range of sensory organs is found to be larger than that of a single neuron, suggesting that the network structure plays a key role in the behavior of both the scaling exponent and the dynamic range of neuron assemblies. In order to verify computationally the relationships between stimulus and response for spiking neurons, we investigate small-world networks of neurons described by the Hodgkin-Huxley equations connected by chemical synapses. We found that the dynamic range increases with the network size, suggesting that the enhancement of the dynamic range observed in sensory organs, with respect to single neurons, is an emergent property of complex network dynamics.

  1. Rhythmic Oscillations of Excitatory Bursting Hodkin-Huxley Neuronal Network with Synaptic Learning.

    Science.gov (United States)

    Shi, Qi; Han, Fang; Wang, Zhijie; Li, Caiyun

    2016-01-01

    Rhythmic oscillations of neuronal network are actually kind of synchronous behaviors, which play an important role in neural systems. In this paper, the properties of excitement degree and oscillation frequency of excitatory bursting Hodkin-Huxley neuronal network which incorporates a synaptic learning rule are studied. The effects of coupling strength, synaptic learning rate, and other parameters of chemical synapses, such as synaptic delay and decay time constant, are explored, respectively. It is found that the increase of the coupling strength can weaken the extent of excitement, whereas increasing the synaptic learning rate makes the network more excited in a certain range; along with the increasing of the delay time and the decay time constant, the excitement degree increases at the beginning, then decreases, and keeps stable. It is also found that, along with the increase of the synaptic learning rate, the coupling strength, the delay time, and the decay time constant, the oscillation frequency of the network decreases monotonically.

  2. Temperature Effects on Information Capacity and Energy Efficiency of Hodgkin-Huxley Neuron

    Science.gov (United States)

    Wang, Long-Fei; Jia, Fei; Liu, Xiao-Zhi; Song, Ya-Lei; Yu, Lian-Chun

    2015-10-01

    Recent experimental and theoretical studies show that energy efficiency, which measures the amount of information processed by a neuron with per unit of energy consumption, plays an important role in the evolution of neural systems. Here, we calculated the information rates and energy efficiencies of the Hodgkin-Huxley (HH) neuron model at different temperatures in a noisy environment. We found that both the information rate and energy efficiency are maximized by certain temperatures. Though the information rate and energy efficiency cannot be maximized simultaneously, the neuron holds a high information processing capacity at the temperature corresponding to maximal energy efficiency. Our results support the idea that the energy efficiency is a selective pressure that influences the evolution of nervous systems.

  3. Delay-enhanced coherence of spiral waves in noisy Hodgkin-Huxley neuronal networks

    Energy Technology Data Exchange (ETDEWEB)

    Wang Qingyun [State Key Laboratory for Turbulence and Complex Systems, Department of Mechanics and Aerospace Engineering, College of Engineering, Peking University, Beijing 100871 (China) and School of Statistics and Mathematics, Inner Mongolia Finance and Economics College, Huhhot 010051 (China)], E-mail: nmqingyun@163.com; Perc, Matjaz [Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Koroska cesta 160, SI-2000 Maribor (Slovenia); Duan Zhisheng [State Key Laboratory for Turbulence and Complex Systems, Department of Mechanics and Aerospace Engineering, College of Engineering, Peking University, Beijing 100871 (China); Chen Guanrong [State Key Laboratory for Turbulence and Complex Systems, Department of Mechanics and Aerospace Engineering, College of Engineering, Peking University, Beijing 100871 (China); Department of Electronic Engineering, City University of Hong Kong, Hong Kong (China)

    2008-08-25

    We study the spatial dynamics of spiral waves in noisy Hodgkin-Huxley neuronal ensembles evoked by different information transmission delays and network topologies. In classical settings of coherence resonance the intensity of noise is fine-tuned so as to optimize the system's response. Here, we keep the noise intensity constant, and instead, vary the length of information transmission delay amongst coupled neurons. We show that there exists an intermediate transmission delay by which the spiral waves are optimally ordered, hence indicating the existence of delay-enhanced coherence of spatial dynamics in the examined system. Additionally, we examine the robustness of this phenomenon as the diffusive interaction topology changes towards the small-world type, and discover that shortcut links amongst distant neurons hinder the emergence of coherent spiral waves irrespective of transmission delay length. Presented results thus provide insights that could facilitate the understanding of information transmission delay on realistic neuronal networks.

  4. Synchronization control of Hodgkin-Huxley neurons exposed to ELF electric field

    Energy Technology Data Exchange (ETDEWEB)

    Che Yanqiu [School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072 (China); Wang Jiang [School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072 (China)], E-mail: jiangwang@tju.edu.cn; Zhou Sisi; Deng Bin [School of Electrical Engineering and Automation, Tianjin University, Tianjin 300072 (China)

    2009-05-30

    This paper presents an adaptive neural network H{sub {infinity}} control for unidirectional synchronization of modified Hodgkin-Huxley (HH) neurons exposed to extremely low frequency (ELF) electric field. The proposed modified HH neurons exhibit periodic and chaotic dynamics in response to sinusoidal electric field stimulation. Based on the Lyapunov stability theory, we derive the updated laws of neural network for approximating the nonlinear uncertain functions of the error dynamical system. The H{sub {infinity}} design technique makes the controller robust to unmodeled dynamics, disturbances and approximate errors. The proposed controller not only ensures closed-loop stability, but also guarantees an H{sub {infinity}} performance for the synchronization error system. The states of the controlled slave system exponentially synchronize with that of the master one after control. The simulation results demonstrate the validity of the proposed method.

  5. Autaptic activity-induced synchronization transitions in Newman-Watts network of Hodgkin-Huxley neurons

    Science.gov (United States)

    Wu, Yanan; Gong, Yubing; Wang, Qi

    2015-04-01

    In this paper, we numerically study the effect of autapse on the synchronization of Newman-Watts small-world Hodgkin-Huxley neuron network. It is found that the neurons exhibit synchronization transitions as autaptic self-feedback delay is varied, and the phenomenon becomes strongest when autaptic self-feedback strength is optimal. This phenomenon also changes with the change of coupling strength and network randomness and become strongest when they are optimal. There are similar synchronization transitions for electrical and chemical autapse, but the synchronization transitions for chemical autapse occur more frequently and are stronger than those for electrical synapse. The underlying mechanisms are briefly discussed in quality. These results show that autaptic activity plays a subtle role in the synchronization of the neuronal network. These findings may find potential implications of autapse for the information processing and transmission in neural systems.

  6. Dynamic Behavior of Artificial Hodgkin-Huxley Neuron Model Subject to Additive Noise.

    Science.gov (United States)

    Kang, Qi; Huang, BingYao; Zhou, MengChu

    2016-09-01

    Motivated by neuroscience discoveries during the last few years, many studies consider pulse-coupled neural networks with spike-timing as an essential component in information processing by the brain. There also exists some technical challenges while simulating the networks of artificial spiking neurons. The existing studies use a Hodgkin-Huxley (H-H) model to describe spiking dynamics and neuro-computational properties of each neuron. But they fail to address the effect of specific non-Gaussian noise on an artificial H-H neuron system. This paper aims to analyze how an artificial H-H neuron responds to add different types of noise using an electrical current and subunit noise model. The spiking and bursting behavior of this neuron is also investigated through numerical simulations. In addition, through statistic analysis, the intensity of different kinds of noise distributions is discussed to obtain their relationship with the mean firing rate, interspike intervals, and stochastic resonance.

  7. Environmental Impacts on Spiking Properties in Hodgkin-Huxley Neuron with Direct Current Stimulus

    Institute of Scientific and Technical Information of China (English)

    YUAN Chang-Qing; ZHAO Tong-Jun; ZHAN Yong; ZHANG Su-Hua; LIU Hui; ZHANG Yu-Hong

    2009-01-01

    Based on the well accepted Hodgkin-Huxley neuron model, the neuronal intrinsic excitability is studied when the neuron is subject to varying environmental temperatures, the typical impact for its regulating ways. With computer simulation, it is found that altering environmental temperature can improve or inhibit the neuronal intrinsic excitability so as to influence the neuronal spiking properties. The impacts from environmental factors can be understood that ,the neuronal spiking threshold is essentially influenced by the fluctuations in the environ-ment. With the environmental temperature varying, burst spiking is realized for the neuronal membrane voltage because of the environment-dependent spiking threshold. This burst induced by changes in spiking threshold is different from that excited by input currents or other stimulus.

  8. Studies of phase return map and symbolic dynamics in a periodically driven Hodgkin—Huxley neuron

    Science.gov (United States)

    Ding, Jiong; Zhang, Hong; Tong, Qin-Ye; Chen, Zhuo

    2014-02-01

    How neuronal spike trains encode external information is a hot topic in neurodynamics studies. In this paper, we investigate the dynamical states of the Hodgkin—Huxley neuron under periodic forcing. Depending on the parameters of the stimulus, the neuron exhibits periodic, quasiperiodic and chaotic spike trains. In order to analyze these spike trains quantitatively, we use the phase return map to describe the dynamical behavior on a one-dimensional (1D) map. According to the monotonicity or discontinuous point of the 1D map, the spike trains are transformed into symbolic sequences by implementing a coarse-grained algorithm — symbolic dynamics. Based on the ordering rules of symbolic dynamics, the parameters of the external stimulus can be measured in high resolution with finite length symbolic sequences. A reasonable explanation for why the nervous system can discriminate or cognize the small change of the external signals in a short time is also presented.

  9. Noise-induced synchronization in a lattice Hodgkin-Huxley neural network

    Science.gov (United States)

    Pang, James Christopher S.; Monterola, Christopher P.; Bantang, Johnrob Y.

    2014-01-01

    We examine how the synchronization of the series of action potentials (APs) of realistic neurons interconnected in a lattice is influenced by variations of both the direction and magnitude of neuron-neuron connectivity in a noisy environment. We first demonstrate the existence of an optimal noise level that brings about the highest average number of APs per unit time, for a single Hodgkin-Huxley neuron. We then show that synchronization, as a collective response of interconnected neurons forming an N×N lattice, is optimal at different noise strengths σc=σc(p), depending on the degree of random-link malfunction parameterized by flipping direction probability p. Thus, even without the scale-free structure of neuronal networks, proper combinations of both randomness in reconnection (flipping) and noisy environment can be beneficial to the collective functioning of neurons.

  10. Langevin approach with rescaled noise for stochastic channel dynamics in Hodgkin-Huxley neurons

    Science.gov (United States)

    Huang, Yan-Dong; Xiang, Li; Shuai, Jian-Wei

    2015-12-01

    The Langevin approach has been applied to model the random open and closing dynamics of ion channels. It has long been known that the gate-based Langevin approach is not sufficiently accurate to reproduce the statistics of stochastic channel dynamics in Hodgkin-Huxley neurons. Here, we introduce a modified gate-based Langevin approach with rescaled noise strength to simulate stochastic channel dynamics. The rescaled independent gate and identical gate Langevin approaches improve the statistical results for the mean membrane voltage, inter-spike interval, and spike amplitude. Project supported by the National Natural Science Foundation for Distinguished Young Scholars of China (Grant No. 11125419), the National Natural Science Foundation of China (Grant No. 10925525), and the Funds for the Leading Talents of Fujian Province, China.

  11. In-phase and anti-phase synchronization in noisy Hodgkin-Huxley neurons.

    Science.gov (United States)

    Ao, Xue; Hänggi, Peter; Schmid, Gerhard

    2013-09-01

    We numerically investigate the influence of intrinsic channel noise on the dynamical response of delay-coupling in neuronal systems. The stochastic dynamics of the spiking is modeled within a stochastic modification of the standard Hodgkin-Huxley model wherein the delay-coupling accounts for the finite propagation time of an action potential along the neuronal axon. We quantify this delay-coupling of the Pyragas-type in terms of the difference between corresponding presynaptic and postsynaptic membrane potentials. For an elementary neuronal network consisting of two coupled neurons we detect characteristic stochastic synchronization patterns which exhibit multiple phase-flip bifurcations: The phase-flip bifurcations occur in form of alternate transitions from an in-phase spiking activity towards an anti-phase spiking activity. Interestingly, these phase-flips remain robust for strong channel noise and in turn cause a striking stabilization of the spiking frequency.

  12. A Response to Eugene and Kiyo’s Dialogue-Disagreement on Dialogic Pedagogy

    Directory of Open Access Journals (Sweden)

    Beth Ferholt

    2014-10-01

    Full Text Available Thank you for asking me to respond to the text that you have created, Eugene and Kiyo. I will write about the “freedom from,” which Eugene raises and which Kiyo addresses at the end of the text. Kiyo points out that when the teacher’s primary active engagement with the learner is to respect the learner’s freedom from, then ‘engaging with others actively to facilitate their learning and the development of their agency’ (pedagogy itself is hindering the development of self-generated authorship (or making people responsive.

  13. Obituary: Harding Eugene (Gene) Smith, Jr., 1947-2007

    Science.gov (United States)

    Lonsdale, Carol; Soifer, Tom

    2009-01-01

    Harding Eugene Smith Junior, or Gene, as he was known to family, friends, and colleagues, passed away after an automobile accident in Encinitas, California, on 16 August 2007. He was 60 years old. Gene had recently retired from UCSD after thirty years of service. A memorial service was held at Quail Botanical Gardens in Encinitas, California, on 23 August 2007. A web page is dedicated to his memory at http://harding.smith.muchloved.com, where contributions of memories are invited. Gene was born in San Jose, California in 1947, to Harding Eugene Smith Senior, and Bernice Smith (nee Smith). Harding Smith Senior was an air-force navigator; therefore Gene spent his childhood moving from one air-force base to another. Although an only child, Gene was very close to his cousin Meg, whom he lived nearby to in Gilroy for a time, and the two were like brother and sister. The elder Harding Smith was lost in action over Cambodia in the mid-sixties. Gene was a dedicated student, a boy scout, and a Presidential Scholar. He majored in Physics at Caltech, where he also took a lively interest in the football team and the Glee Club, and was elected a House Officer. To his close friends, he was known at Caltech as Smitty, and the closest of them was Rob Drew, who gave a glimpse into that period of Gene's life at the memorial: "Gene arrived early at campus his first year, in response to an invitation to join the football team. Gene's size and features reminded the head coach of a long-forgotten player named 'Johnson.' After a few days of confusion, Gene simply replaced the name on his helmet. 'Johnson!' coach would yell, 'get in there!' If Johnson was going to get to play, Gene was going to be the best Johnson available!" Gene spent the summer of 1966 working at Kitt Peak, where his lifetime love of observing with ground-based telescopes began, though he learned some things the hard way, such as the fact that trying to squeeze 40,000 numbers onto a computer that stored only 32

  14. The Killing Thought in the Eugenic Era and Today: A Commentary on Hollander's Essay.

    Science.gov (United States)

    Wolfensberger, Wolf

    1989-01-01

    Two responses to Hollander (EC 220 057) and the author's counter-response note similarities between "mercy killing" of people with mental retardation and deliberate abortion of the unborn, misuse of the history of eugenics, and a defense of the author's historical scholarship. (DB)

  15. Hereditarian Ideas and Eugenic Ideals at the National Deaf-Mute College

    Science.gov (United States)

    Ennis, William Thomas, III

    2015-01-01

    For the past two centuries deaf people in the United States have faced more or less intense skepticism about their marriages to each other, largely due to fears of inherited deafness. These fears, while always present, have waxed and waned over time, becoming most prominent during the eugenics era of the late nineteenth and early twentieth…

  16. Reflections on Mental Retardation and Eugenics, Old and New: Mensa and the Human Genome Project.

    Science.gov (United States)

    Smith, J. David

    1994-01-01

    This article addresses the moral and ethical issues of mental retardation and a continuing legacy of belief in eugenics. It discusses the involuntary sterilization of Carrie Buck in 1927, support for legalized killing of subnormal infants by 47% of respondents to a Mensa survey, and implications of the Human Genome Project for the field of mental…

  17. Eugene Wigner – A Gedanken Pioneer of the Second Quantum Revolution

    Directory of Open Access Journals (Sweden)

    Zeilinger Anton

    2014-01-01

    Full Text Available Eugene Wigner pointed out very interesting consequences of quantum physics in elegant gedanken experiments. As a result of technical progress, these gedanken experiments have become real experiments and contribute to the development of novel concepts in quantum information science, often called the second quantum revolution.

  18. In Memory of Professors Chen Yaozhen (Eugene Chan) and Mao Wenshu (Winifred Mao)

    Institute of Scientific and Technical Information of China (English)

    Lezheng Wu

    2002-01-01

    @@ It has been 16 and 14 years respectively since Professor Chen Yaozhen (Eugene Chan) and Pro-fessor Mao Wenshu (Winifred Mao) passed away. We recollect the great and extraordinary lives ofthese two seniors, their outstanding achievements and contributions as well as the unforgettable andvaluable academic heritages left by them to the ophthalmology in China.

  19. Ethnic, Familial and Catholic Elements in Eugene O'Neill's Long Day's Journey Into Night

    Institute of Scientific and Technical Information of China (English)

    纪小军

    2010-01-01

    In the plays of Eugene O'Neill. American's leading and foremost creative playwright, can be found the influence of his Irish and Catholic background. This paper attempts to explore the influence of O'Neill's ethnic, familial and religious background upon his thinly disguised autobiographical materpiece Long Day' s Journey Into Night.

  20. EUGENICS, THE GIRARDIAN THEORY OF SACRIFICE, AND THE NEW DARWINIAN ETHICS

    Directory of Open Access Journals (Sweden)

    THOMAS RYBA

    2011-11-01

    Full Text Available In this paper I argue that, though many ethical systems recognizesacrifice as moral action, the utilitarian appropriation of Neo-Darwinian theory especially as it justifies eugenics as a “winnowing of the human stock” is in Girardian terms analogous to the sacrificial scapegoating of innocents. This argument is accomplished in four steps. (1 I show that within some ethical systems sacrifice is recognized as moral behavior driven by a specific axiology (or theory of value (2 I discuss some of the meta-ethical problems connected with Neo-Darwinian naturalism and naturalism, in general. (3 I show how modern varieties of naturalism and Darwinian naturalism, inparticular are especially inclined to lead to a moral justification of eugenic scapegoating and how Girardian theory is helpful in identifying the moral disorder connected with eugenics. (4 Finally, I conclude by arguing that Darwin’s thought is susceptible to another kind of interpretation, one that need not lead to the valorization of eugenics.

  1. An Interview with Eugene Genovese: The Rise of a Marxist Historian.

    Science.gov (United States)

    Radosh, Ronald

    1978-01-01

    Eugene D. Genovese, the new president of the Organization of American Historians, and the first Marxist to hold that post, is interviewed. Among the topics discussed are the Bertell Ollman incident at the University of Maryland, academic freedom and political discrimination on campus, campus activism, and Genovese's academic career. (JMD)

  2. A not-so-new eugenics. Harris and Savulescu on human enhancement.

    Science.gov (United States)

    Sparrow, Robert

    2011-01-01

    John Harris and Julian Savulescu, leading figures in the "new' eugenics, argue that parents are morally obligated to use genetic and other technologies to enhance their children. But the argument they give leads to conclusions even more radical than they acknowledge. Ultimately, the world it would lead to is not all that different from that championed by eugenicists one hundred years ago.

  3. Reflections on Mental Retardation and Eugenics, Old and New: Mensa and the Human Genome Project.

    Science.gov (United States)

    Smith, J. David

    1994-01-01

    This article addresses the moral and ethical issues of mental retardation and a continuing legacy of belief in eugenics. It discusses the involuntary sterilization of Carrie Buck in 1927, support for legalized killing of subnormal infants by 47% of respondents to a Mensa survey, and implications of the Human Genome Project for the field of mental…

  4. The Human Genome Project and Eugenics: Identifying the Impact on Individuals with Mental Retardation.

    Science.gov (United States)

    Kuna, Jason

    2001-01-01

    This article explores the impact of the mapping work of the Human Genome Project on individuals with mental retardation and the negative effects of genetic testing. The potential to identify disabilities and the concept of eugenics are discussed, along with ethical issues surrounding potential genetic therapies. (Contains references.) (CR)

  5. Eugenics for the doctors: medicine and social control in 1930s Turkey.

    Science.gov (United States)

    Salgirli, Sanem Güvenç

    2011-07-01

    This article aims to add a new dimension to the analysis of the relationship between medicine and eugenics via a discussion of the community of Turkish physicians in the period between the two World Wars. It argues that even though the relationship between the two fields has been discussed before in terms of the professional ideology of doctors, the medical community itself has not come under scrutiny by scholars. It is the purpose of this article to show eugenics as the main unifying edifice of that community and argue that eugenics is to be found in the patterns of social reproduction of the doctors as part of the professional middle class in addition to being those who transfer knowledge of medicine. As can be seen in Turkey in the 1930s, the doctors, in their efforts to construct themselves as the pioneers of modern scientific medicine, as well as the new ruling class of the country, used eugenics extensively both as a means of self-identification, and as a way to build a professional class "fit" to rule the country.

  6. Eugenics and Education: A Note on the Origins of the Intelligence Testing Movement in England.

    Science.gov (United States)

    Lowe, Roy

    1980-01-01

    Examines influence of Francis Galton and the Eugenics Education Society in the intelligence testing movement in England (early 1900s). For eugenicists, the central issue confronting society was the problem of racial deterioration. They responded with modification of the Binet-Simon tests and developed tests to examine the whole ability range.…

  7. The Killing Thought in the Eugenic Era and Today: A Commentary on Hollander's Essay.

    Science.gov (United States)

    Wolfensberger, Wolf

    1989-01-01

    Two responses to Hollander (EC 220 057) and the author's counter-response note similarities between "mercy killing" of people with mental retardation and deliberate abortion of the unborn, misuse of the history of eugenics, and a defense of the author's historical scholarship. (DB)

  8. Education Policy and Biological Science: Genetics, Eugenics, and the College Textbook, c. 1908-1931.

    Science.gov (United States)

    Selden, Steven

    1985-01-01

    A revolution in genetics is occurring, but when looking ahead, we must not romanticize the past. The social history of genetics, and American education's association with eugenics, make it necessary that we understand that both education and science are informed by social attitudes. (MT)

  9. The Hunt for Disability: The New Eugenics and the Normalization of School Children.

    Science.gov (United States)

    Baker, Bernadette

    2002-01-01

    Examines issues of sameness, difference, equality, and democracy in present public school systems, focusing on the question of (dis)ability and implications of rethinking (dis)ability as an ontological issue before its inscription as an educational one concerning the politics of inclusion. The paper analyzes old and new discourses of eugenics as…

  10. [On the medical and publishing activities of the community of Saint Eugene].

    Science.gov (United States)

    2012-01-01

    The article deals with the role the physicians played in organization and functioning of the Community of Saint Eugene in St. Petersburg in 1882-1918. The typography production of the Community being of interest for history of medicine is examined.

  11. A new domain decomposition algorithm for generalized Burger's-Huxley equation based on Chebyshev polynomials and preconditioning

    Energy Technology Data Exchange (ETDEWEB)

    Javidi, M. [Department of Mathematics, Iran University of Science and Technology, Narmak, Tehran 16844 (Iran, Islamic Republic of)], E-mail: mo_javidi@yahoo.com; Golbabai, A. [Department of Mathematics, Iran University of Science and Technology, Narmak, Tehran 16844 (Iran, Islamic Republic of)], E-mail: golbabai@iust.ac.ir

    2009-01-30

    In this study, we use the spectral collocation method using Chebyshev polynomials for spatial derivatives and fourth order Runge-Kutta method for time integration to solve the generalized Burger's-Huxley equation (GBHE). To reduce round-off error in spectral collocation (pseudospectral) method we use preconditioning. Firstly, theory of application of Chebyshev spectral collocation method with preconditioning (CSCMP) and domain decomposition on the generalized Burger's-Huxley equation presented. This method yields a system of ordinary differential algebric equations (DAEs). Secondly, we use fourth order Runge-Kutta formula for the numerical integration of the system of DAEs. The numerical results obtained by this way have been compared with the exact solution to show the efficiency of the method.

  12. Watching the 'eugenic experiment' unfold: the mixed views of British eugenicists toward Nazi Germany in the early 1930s.

    Science.gov (United States)

    Hart, Bradley W

    2012-01-01

    Historians of the eugenics movement have long been ambivalent in their examination of the links between British hereditary researchers and Nazi Germany. While there is now a clear consensus that American eugenics provided significant material and ideological support for the Germans, the evidence remains less clear in the British case where comparatively few figures openly supported the Nazi regime and the left-wing critique of eugenics remained particularly strong. After the Second World War British eugenicists had to push back against the accusation that their science was intrinsically dictatorial or totalitarian and, as a result, many of their early perceptions of the Nazis were ignored or rationalised away. Further, historians in recent years have focused more directly on the social reformist elements of eugenics, discussing the links between hereditary science and the birth control and feminist movements in addition to others. While undoubtedly making valuable contributions to the scholarly understanding of the eugenic milieu in the interwar years, these studies have neglected to recontextualize the sentiments of British eugenicists who did indeed view the Nazi government positively in the early years of the 1930s. This article argues that there was a significant, though not numerically sizable, faction in the British eugenics movement, though mostly outside the Eugenics Society itself, in the early 1930s that viewed the Nazi Germany as an admirable state for its implementation of eugenic principles. One of these figures was later interned by his own government for being too closely aligned with the German regime, though he argued that this affinity was driven by the quest for scientific truth rather than politics. Eugenics in Britain thus contained a greater diversity of views toward Germany than scholars have previously assumed, warranting more research into the individuals and organizations harbouring these views.

  13. Travelling solitary wave solutions for the generalized Burgers-Huxley equation with nonlinear terms of any order

    Institute of Scientific and Technical Information of China (English)

    Deng Xi-Jun; Yan Zi-Zong; Han Li-Bo

    2009-01-01

    In this paper,the travelling wave solutions for the generalized Burgers-Huxley equation with nonlinear terms of any order are studied.By using the first integral method,which is based on the divisor theorem,some exact explicit travelling solitary wave solutions for the above equation are obtained.As a result,some minor errors and some known results in the previousl literature are clarified and improved.

  14. Existential concerns and narrative techniques in the novels of Ford Madox Ford, Virginia Wools and Aldous Huxley

    Directory of Open Access Journals (Sweden)

    Radojka Verčko

    2005-12-01

    Full Text Available The article addresses the issue of the close relationship between the nexistential concem and the narrative techniques used by English writers Ford Madox Ford, Virginia Woolf and Aldous Huxley to present the general human condition. The selected authors had introduced narrative techniques that influenced the entire development of the modern  novel and that are stili highly  relevant and widely used in the contemporary novel, including the Slovene modern novel.

  15. Proceedings of the National Silviculture Workshop: Density of Stocking Control; Eugene, Oregon; October 13-15, 1976

    Science.gov (United States)

    Jack H. Usher; Daniel B. Jones; A. R. Stage; Benjamin A. Roach; Gilbert B. Schubert; Darrell W. Crawford; Gilbert H. Schubert; Walter Fox; Edward A. Smith; Richard E. Lowrey Sofes; Richard F. Watt

    1976-01-01

    The 1976 National Silviculture Workshop was held in Eugene, Oregon, on October 13-15, 1976. The objectives were to discuss second growth management of individual stands, with particular emphasis on the control of stand density.

  16. Mäletamine, aeglus ja kontrollimatu kapitalism / Eugen Ruge ; intervjueerinud Dieter Neidlinger ; saksa keelest eesti keelde vahendanud Aija Sakova

    Index Scriptorium Estoniae

    Ruge, Eugen, 1954-

    2016-01-01

    Intervjuu kirjandusfestivalil "Prima vista" esineva saksa kirjaniku Eugen Rugega tema romaanides "Kahaneva valguse aegu" ("In Zeiten des abnehmenden Lichts") ja "Cabo de Gata" ning käsil olevast teosest

  17. [Eugen Helimski, Urlike Kahrs. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903)] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2003-01-01

    Raamatust: Helimski, Eugen, Kahrs, Urlike. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903). Hamburg, 2001. (Hamburger Sibirische und Finnisch-Ugrische Materialen / Habent Sua Fata Manuscripts; 1)

  18. [Eugen Helimski, Urlike Kahrs. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903)] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2003-01-01

    Raamatust: Helimski, Eugen, Kahrs, Urlike. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903). Hamburg, 2001. (Hamburger Sibirische und Finnisch-Ugrische Materialen / Habent Sua Fata Manuscripts; 1)

  19. "Hopelessly entangled in Nordic pre-suppositions": Catholic participation in the American Eugenics Society in the 1920s.

    Science.gov (United States)

    Leon, Sharon M

    2004-01-01

    While American Catholics stand out as some of the few voices of cultural opposition to the eugenics movement in the United States, Catholics and eugenicists actively engaged in conversational exchanges during the late 1920s. In association with the Committee on Cooperation with Clergymen of the American Eugenics Society, John A. Ryan and John Montgomery Cooper engaged in a process that Sander Gilman and Nancy Leys Stepan call "recontextualization," whereby they challenged the social and scientific basis for eugenics policy initiatives while constantly urging American eugenicists to rid their movement of racial and class prejudice. In the process, they participated in a revealing debate on immigration restriction, charity, racial hierarchies, feminism, birth control, and sterilization that points to both the instances of convergence and divergence of Catholic and eugenic visions for the national community.

  20. Mäletamine, aeglus ja kontrollimatu kapitalism / Eugen Ruge ; intervjueerinud Dieter Neidlinger ; saksa keelest eesti keelde vahendanud Aija Sakova

    Index Scriptorium Estoniae

    Ruge, Eugen, 1954-

    2016-01-01

    Intervjuu kirjandusfestivalil "Prima vista" esineva saksa kirjaniku Eugen Rugega tema romaanides "Kahaneva valguse aegu" ("In Zeiten des abnehmenden Lichts") ja "Cabo de Gata" ning käsil olevast teosest

  1. Modelling spatiotemporal olfactory data in two steps: from binary to Hodgkin-Huxley neurones.

    Science.gov (United States)

    Quenet, Brigitte; Dubois, Rémi; Sirapian, Sevan; Dreyfus, Gérard; Horn, David

    2002-01-01

    Network models of synchronously updated McCulloch-Pitts neurones exhibit complex spatiotemporal patterns that are similar to activities of biological neurones in phase with a periodic local field potential, such as those observed experimentally by Wehr and Laurent (1996, Nature 384, 162-166) in the locust olfactory pathway. Modelling biological neural nets with networks of simple formal units makes the dynamics of the model analytically tractable. It is thus possible to determine the constraints that must be satisfied by its connection matrix in order to make its neurones exhibit a given sequence of activity (see, for instance, Quenet et al., 2001, Neurocomputing 38-40, 831-836). In the present paper, we address the following question: how can one construct a formal network of Hodgkin-Huxley (HH) type neurones that reproduces experimentally observed neuronal codes? A two-step strategy is suggested in the present paper: first, a simple network of binary units is designed, whose activity reproduces the binary experimental codes; second, this model is used as a guide to design a network of more realistic formal HH neurones. We show that such a strategy is indeed fruitful: it allowed us to design a model that reproduces the Wehr-Laurent olfactory codes, and to investigate the robustness of these codes to synaptic noise.

  2. Neural Energy Supply-Consumption Properties Based on Hodgkin-Huxley Model

    Science.gov (United States)

    2017-01-01

    Electrical activity is the foundation of the neural system. Coding theories that describe neural electrical activity by the roles of action potential timing or frequency have been thoroughly studied. However, an alternative method to study coding questions is the energy method, which is more global and economical. In this study, we clearly defined and calculated neural energy supply and consumption based on the Hodgkin-Huxley model, during firing action potentials and subthreshold activities using ion-counting and power-integral model. Furthermore, we analyzed energy properties of each ion channel and found that, under the two circumstances, power synchronization of ion channels and energy utilization ratio have significant differences. This is particularly true of the energy utilization ratio, which can rise to above 100% during subthreshold activity, revealing an overdraft property of energy use. These findings demonstrate the distinct status of the energy properties during neuronal firings and subthreshold activities. Meanwhile, after introducing a synapse energy model, this research can be generalized to energy calculation of a neural network. This is potentially important for understanding the relationship between dynamical network activities and cognitive behaviors. PMID:28316842

  3. Neural Energy Supply-Consumption Properties Based on Hodgkin-Huxley Model

    Directory of Open Access Journals (Sweden)

    Yihong Wang

    2017-01-01

    Full Text Available Electrical activity is the foundation of the neural system. Coding theories that describe neural electrical activity by the roles of action potential timing or frequency have been thoroughly studied. However, an alternative method to study coding questions is the energy method, which is more global and economical. In this study, we clearly defined and calculated neural energy supply and consumption based on the Hodgkin-Huxley model, during firing action potentials and subthreshold activities using ion-counting and power-integral model. Furthermore, we analyzed energy properties of each ion channel and found that, under the two circumstances, power synchronization of ion channels and energy utilization ratio have significant differences. This is particularly true of the energy utilization ratio, which can rise to above 100% during subthreshold activity, revealing an overdraft property of energy use. These findings demonstrate the distinct status of the energy properties during neuronal firings and subthreshold activities. Meanwhile, after introducing a synapse energy model, this research can be generalized to energy calculation of a neural network. This is potentially important for understanding the relationship between dynamical network activities and cognitive behaviors.

  4. Biophysical synaptic dynamics in an analog VLSI network of Hodgkin-Huxley neurons.

    Science.gov (United States)

    Yu, Theodore; Cauwenberghs, Gert

    2009-01-01

    We study synaptic dynamics in a biophysical network of four coupled spiking neurons implemented in an analog VLSI silicon microchip. The four neurons implement a generalized Hodgkin-Huxley model with individually configurable rate-based kinetics of opening and closing of Na+ and K+ ion channels. The twelve synapses implement a rate-based first-order kinetic model of neurotransmitter and receptor dynamics, accounting for NMDA and non-NMDA type chemical synapses. The implemented models on the chip are fully configurable by 384 parameters accounting for conductances, reversal potentials, and pre/post-synaptic voltage-dependence of the channel kinetics. We describe the models and present experimental results from the chip characterizing single neuron dynamics, single synapse dynamics, and multi-neuron network dynamics showing phase-locking behavior as a function of synaptic coupling strength. The 3mm x 3mm microchip consumes 1.29 mW power making it promising for applications including neuromorphic modeling and neural prostheses.

  5. Effect of channel block on the collective spiking activity of coupled stochastic Hodgkin-Huxley neurons

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Toxins, such as tetraethylammonium (TEA) and tetrodotoxin (TTX), can make potassium or sodium ion channels poisoned, respectively, and hence reduce the number of working ion channels and lead to the diminishment of conductance. In this paper, we have studied by numerical simulations the effects of sodium and potassium ion channel poisoning on the collective spiking activity of an array of coupled stochastic Hodgkin-Huxley (HH) neurons. It is found for a given number of neurons sodium or potas- sium ion channel block can either enhance or reduce the collective spiking regularity, depending on the membrane patch size. For a given smaller or larger patch size, potassium and sodium ion channel block can reduce or enhance the collective spiking regularity, but they have different patch size ranges for the transformation. This result shows that sodium or potassium ion channel block might have dif- ferent effects on the collective spiking activity in coupled HH neurons from the effects for a single neuron, which represents the interplay among the diminishment of maximal conductance and the in- crease of channel noise strength due to the channel blocks, as well as the bi-directional coupling be- tween the neurons.

  6. Response of autaptic Hodgkin-Huxley neuron with noise to subthreshold sinusoidal signals

    Science.gov (United States)

    Wang, Hengtong; Chen, Yong

    2016-11-01

    In this work, we investigated the response of a stochastic Hodgkin-Huxley (HH) neuron with an autapse to subthreshold sinusoidal signals. It is found that the autapse not only adjusts the stochastic responses, but also improves the detection of subthreshold signals. In the case of weak noise, the autapse facilitates the response of neuron to the subthreshold sinusoidal signals with a small parameter region in tdelay- ω space. The increased noise intensity enlarges this parameter region and increases the corresponding response frequency in such range. As the autaptic intensity increases, however, this parameter region shrunks. We also observed that there is an optimal range of the delay time of autapse, within which the stochastic HH neuron fires action potentials with high frequency. The corresponding response spike train for the optimal delay time is nearly a regular sequence with the interspike intervals approximated to the delay time. The current results reveal a novel resonance phenomenon facilitated by autapse, named autaptic delay-induced coherence resonance.

  7. Bistability and resonance in the periodically stimulated Hodgkin-Huxley model with noise

    CERN Document Server

    Borkowski, L S

    2010-01-01

    We describe general characteristics of the Hodgkin-Huxley neuron's response to a periodic train of short current pulses with Gaussian noise. The deterministic neuron is bistable for antiresonant frequencies. When the stimuli arrive at the resonant frequency the firing rate is a continuous function of the current amplitude $I_0$ and scales as $(I_0-I_{th})^{1/2}$, where $I_{th}$ is an approximate threshold. Intervals of continuous irregular response alternate with integer mode-locked regions with bistable excitation edge. There is an even-all multimodal transition between the 2:1 and 3:1 states in the vicinity of the main resonance, which is analogous to the odd-all transition discovered earlier in the high-frequency regime. For $I_0

  8. Theoretical analysis of transcranial magneto-acoustical stimulation with Hodgkin–Huxley neuron model

    Directory of Open Access Journals (Sweden)

    Yi eYuan

    2016-04-01

    Full Text Available Transcranial magneto-acoustical stimulation (TMAS is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing rhythm remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons with a Hodgkin-Huxley neuron model. The simulation results indicate that the magnetostatic field intensity and ultrasonic power can affect the amplitude and interspike interval of neuronal action potential under continuous wave ultrasound. The simulation results also show that the ultrasonic power, duty cycle and repetition frequency can alter the firing rhythm of neural action potential under pulsed ultrasound. This study can help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

  9. Response of the Hodgkin-Huxley neuron to a periodic sequence of biphasic pulses

    CERN Document Server

    Borkowski, L S

    2013-01-01

    We study the response of the Hodgkin-Huxley neuron stimulated periodically by biphasic rectangular current pulses. The optimal response for charge-balanced input is obtained for cathodic-first pulses with an inter-phase gap (IPG) approximately equal 5 ms. For short pulses the topology of the global bifurcation diagram in the period-amplitude plane is approximately invariant with respect to the pulse polarity and shape details. If stimuli are delivered at neuron's resonant frequencies the firing rate is a continuous function of pulse amplitude. At nonresonant frequencies the quiescent state and the firing state coexist over a range of amplitude values and the transition to excitability is a discontinuous one. There is a multimodal odd-all transition between the 2:1 and 3:1 locked-in states. A strong antiresonant effect is found between the states 3:1 and 4:1, where the modes (2+3n):1, $n=0,1,2,...$, are entirely absent. At high frequencies the excitation threshold is a nonmonotonic function of the stimulus and...

  10. Response of a Hodgkin-Huxley neuron to a high-frequency input

    CERN Document Server

    Borkowski, L S

    2010-01-01

    We study the response of a Hodgkin-Huxley neuron stimulated by a periodic sequence of conductance pulses arriving through the synapse in the high frequency regime. In addition to the usual excitation threshold there is a smooth crossover from the firing to the silent regime for increasing pulse amplitude $g_{syn}$. The amplitude of the voltage spikes decreases approximately linearly with $g_{syn}$. In some regions of parameter space the response is irregular, probably chaotic. In the chaotic regime between the mode-locked regions 3:1 and 2:1 near the lower excitation threshold the output interspike interval histogram (ISIH) undergoes a sharp transition. If the driving period is below the critical value, $T_i T^*$ even multiples of $T_i$ also appear in the histogram, starting from the largest values. Near $T^*$ the ISIH scales logarithmically on both sides of the transition. The coefficient of variation of ISIH has a cusp singularity at $T^*$. The average response period has a maximum slightly above $T^*$. Ne...

  11. Neural Energy Supply-Consumption Properties Based on Hodgkin-Huxley Model.

    Science.gov (United States)

    Wang, Yihong; Wang, Rubin; Xu, Xuying

    2017-01-01

    Electrical activity is the foundation of the neural system. Coding theories that describe neural electrical activity by the roles of action potential timing or frequency have been thoroughly studied. However, an alternative method to study coding questions is the energy method, which is more global and economical. In this study, we clearly defined and calculated neural energy supply and consumption based on the Hodgkin-Huxley model, during firing action potentials and subthreshold activities using ion-counting and power-integral model. Furthermore, we analyzed energy properties of each ion channel and found that, under the two circumstances, power synchronization of ion channels and energy utilization ratio have significant differences. This is particularly true of the energy utilization ratio, which can rise to above 100% during subthreshold activity, revealing an overdraft property of energy use. These findings demonstrate the distinct status of the energy properties during neuronal firings and subthreshold activities. Meanwhile, after introducing a synapse energy model, this research can be generalized to energy calculation of a neural network. This is potentially important for understanding the relationship between dynamical network activities and cognitive behaviors.

  12. Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model.

    Science.gov (United States)

    Yuan, Yi; Chen, Yudong; Li, Xiaoli

    2016-01-01

    Transcranial magneto-acoustical stimulation (TMAS) is a novel stimulation technology in which an ultrasonic wave within a magnetostatic field generates an electric current in an area of interest in the brain to modulate neuronal activities. As a key part of the neural network, neurons transmit information in the nervous system. However, the effect of TMAS on the neuronal firing pattern remains unknown. To address this problem, we investigated the stimulatory mechanism of TMAS on neurons, by using a Hodgkin-Huxley neuron model. The simulation results indicated that the magnetostatic field intensity and ultrasonic power affect the amplitude and interspike interval of neuronal action potential under a continuous wave ultrasound. The simulation results also showed that the ultrasonic power, duty cycle and repetition frequency can alter the firing pattern of neural action potential under pulsed wave ultrasound. This study may help to reveal and explain the biological mechanism of TMAS and to provide a theoretical basis for TMAS in the treatment or rehabilitation of neuropsychiatric disorders.

  13. FPGA implementation of a biological neural network based on the Hodgkin-Huxley neuron model.

    Science.gov (United States)

    Yaghini Bonabi, Safa; Asgharian, Hassan; Safari, Saeed; Nili Ahmadabadi, Majid

    2014-01-01

    A set of techniques for efficient implementation of Hodgkin-Huxley-based (H-H) model of a neural network on FPGA (Field Programmable Gate Array) is presented. The central implementation challenge is H-H model complexity that puts limits on the network size and on the execution speed. However, basics of the original model cannot be compromised when effect of synaptic specifications on the network behavior is the subject of study. To solve the problem, we used computational techniques such as CORDIC (Coordinate Rotation Digital Computer) algorithm and step-by-step integration in the implementation of arithmetic circuits. In addition, we employed different techniques such as sharing resources to preserve the details of model as well as increasing the network size in addition to keeping the network execution speed close to real time while having high precision. Implementation of a two mini-columns network with 120/30 excitatory/inhibitory neurons is provided to investigate the characteristic of our method in practice. The implementation techniques provide an opportunity to construct large FPGA-based network models to investigate the effect of different neurophysiological mechanisms, like voltage-gated channels and synaptic activities, on the behavior of a neural network in an appropriate execution time. Additional to inherent properties of FPGA, like parallelism and re-configurability, our approach makes the FPGA-based system a proper candidate for study on neural control of cognitive robots and systems as well.

  14. Strange nonchaotic spiking in the quasiperiodically-forced Hodgkin-Huxley neuron

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Woochang; Kim, Sangyoon [Kangwon National University, Chunchon (Korea, Republic of)

    2010-06-15

    We study the transition from a silent state to a spiking state by varying the dc stimulus in the quasiperiodically-forced Hodgkin-Huxley neuron. For this quasiperiodically-forced case, a new type of strange nonchaotic (SN) spiking state is found to appear between the silent state and the chaotic spiking state as intermediate one. Using a rational approximation to the quasiperiodic forcing, we investigate the mechanism for the appearance of such an SN spiking state. We thus find that a smooth torus (corresponding to the silent state) is transformed into an SN spiking attractor via a phase-dependent saddle-node bifurcation. This is in contrast to the periodically-forced case where the silent state transforms directly to a chaotic spiking state. SN spiking states are characterized in terms of the interspike interval, so they are found to be aperiodic complex ones, as in the case of chaotic spiking states. Hence, aperiodic complex spikings may result from two dynamically different states with strange geometry (one is chaotic and the other one is nonchaotic).

  15. Chimera states in a Hodgkin-Huxley model of thermally sensitive neurons

    Science.gov (United States)

    Glaze, Tera A.; Lewis, Scott; Bahar, Sonya

    2016-08-01

    Chimera states occur when identically coupled groups of nonlinear oscillators exhibit radically different dynamics, with one group exhibiting synchronized oscillations and the other desynchronized behavior. This dynamical phenomenon has recently been studied in computational models and demonstrated experimentally in mechanical, optical, and chemical systems. The theoretical basis of these states is currently under active investigation. Chimera behavior is of particular relevance in the context of neural synchronization, given the phenomenon of unihemispheric sleep and the recent observation of asymmetric sleep in human patients with sleep apnea. The similarity of neural chimera states to neural "bump" states, which have been suggested as a model for working memory and visual orientation tuning in the cortex, adds to their interest as objects of study. Chimera states have been demonstrated in the FitzHugh-Nagumo model of excitable cells and in the Hindmarsh-Rose neural model. Here, we demonstrate chimera states and chimera-like behaviors in a Hodgkin-Huxley-type model of thermally sensitive neurons both in a system with Abrams-Strogatz (mean field) coupling and in a system with Kuramoto (distance-dependent) coupling. We map the regions of parameter space for which chimera behavior occurs in each of the two coupling schemes.

  16. Quantification of degeneracy in Hodgkin-Huxley neurons on Newman-Watts small world network.

    Science.gov (United States)

    Man, Menghua; Zhang, Ya; Ma, Guilei; Friston, Karl; Liu, Shanghe

    2016-08-07

    Degeneracy is a fundamental source of biological robustness, complexity and evolvability in many biological systems. However, degeneracy is often confused with redundancy. Furthermore, the quantification of degeneracy has not been addressed for realistic neuronal networks. The objective of this paper is to characterize degeneracy in neuronal network models via quantitative mathematic measures. Firstly, we establish Hodgkin-Huxley neuronal networks with Newman-Watts small world network architectures. Secondly, in order to calculate the degeneracy, redundancy and complexity in the ensuing networks, we use information entropy to quantify the information a neuronal response carries about the stimulus - and mutual information to measure the contribution of each subset of the neuronal network. Finally, we analyze the interdependency of degeneracy, redundancy and complexity - and how these three measures depend upon network architectures. Our results suggest that degeneracy can be applied to any neuronal network as a formal measure, and degeneracy is distinct from redundancy. Qualitatively degeneracy and complexity are more highly correlated over different network architectures, in comparison to redundancy. Quantitatively, the relationship between both degeneracy and redundancy depends on network coupling strength: both degeneracy and redundancy increase with complexity for small coupling strengths; however, as coupling strength increases, redundancy decreases with complexity (in contrast to degeneracy, which is relatively invariant). These results suggest that the degeneracy is a general topologic characteristic of neuronal networks, which could be applied quantitatively in neuroscience and connectomics.

  17. Bifurcation analysis of delay-induced patterns in a ring of Hodgkin-Huxley neurons.

    Science.gov (United States)

    Kantner, Markus; Yanchuk, Serhiy

    2013-09-28

    Rings of delay-coupled neurons possess a striking capability to produce various stable spiking patterns. In order to reveal the mechanisms of their appearance, we present a bifurcation analysis of the Hodgkin-Huxley (HH) system with delayed feedback as well as a closed loop of HH neurons. We consider mainly the effects of external currents and communication delays. It is shown that typically periodic patterns of different spatial form (wavenumber) appear via Hopf bifurcations as the external current or time delay changes. The Hopf bifurcations are shown to occur in relatively narrow regions of the external current values, which are independent of the delays. Additional patterns, which have the same wavenumbers as the existing ones, appear via saddle-node bifurcations of limit cycles. The obtained bifurcation diagrams are evidence for the important role of communication delays for the emergence of multiple coexistent spiking patterns. The effects of a short-cut, which destroys the rotational symmetry of the ring, are also briefly discussed.

  18. Channel-noise-induced critical slowing in the subthreshold Hodgkin-Huxley neuron

    Science.gov (United States)

    Bukoski, Alex; Steyn-Ross, D. A.; Steyn-Ross, Moira L.

    2015-03-01

    The dynamics of a spiking neuron approaching threshold is investigated in the framework of Markov-chain models describing the random state-transitions of the underlying ion-channel proteins. We characterize subthreshold channel-noise-induced transmembrane potential fluctuations in both type-I (integrator) and type-II (resonator) parametrizations of the classic conductance-based Hodgkin-Huxley equations. As each neuron approaches spiking threshold from below, numerical simulations of stochastic trajectories demonstrate pronounced growth in amplitude simultaneous with decay in frequency of membrane voltage fluctuations induced by ion-channel state transitions. To explore this progression of fluctuation statistics, we approximate the exact Markov treatment with a 12-variable channel-based stochastic differential equation (SDE) and its Ornstein-Uhlenbeck (OU) linearization and show excellent agreement between Markov and SDE numerical simulations. Predictions of the OU theory with respect to membrane potential fluctuation variance, autocorrelation, correlation time, and spectral density are also in agreement and illustrate the close connection between the eigenvalue structure of the associated deterministic bifurcations and the observed behavior of the noisy Markov traces on close approach to threshold for both integrator and resonator point-neuron varieties.

  19. Enhancement of spike coherence by the departure from Gaussian noise in a Hodgkin-Huxley neuron

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Experimental study has shown that non-Gaussian noise exists in sensory systems like neurons.The departure from Gaussian behavior is a characteristic parameter of non-Gaussian noise.In this paper,we have numerically studied the effect of a particular kind of non-Gaussian colored noise(NGN),especially its departure q from Gaussian noise(q = 1),on the spiking activity in a deterministic Hodgkin-Huxley(HH) neuron driven by sub-threshold periodic stimulus.Simulation results show that the departure q can affect the spiking activity induced by noise intensity D.For smaller q values,the minimum in the variation coefficient(CV) as a function of noise intensity(D) becomes smaller,showing that D-induced stochastic resonance(SR) becomes strengthened.Meanwhile,depending on the value of D,q can either enhance or reduce the spiking regularity.Interestingly,CV changes non-monotonously with varying q and passes through a minimum at an intermediate q,representing the presence of "departure-induced SR".This result shows that appropriate departures of the NGN can enhance the spike coherence in the HH neuron.Since the departure of the NGN determines the probability distribution and hence may denote the type of the noise,"departure-induced SR" shows that different types of noise can enhance the spike coherence,and hence may improve the timing precision of sub-threshold signal encoding in the HH neuron.

  20. Delay-induced coherence bi-resonance-like behavior in stochastic Hodgkin-Huxley neuron networks

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In this paper,we study how information transmission delays affect the spiking behavior of electrically coupled stochastic Hodgkin-Huxley (HH) neurons on Newman-Watts networks.It is found that the spiking behavior becomes the most regular at an optimal time delay,indicating the occurrence of delay-induced coherence resonance-like (CR-like) behavior.Interestingly,there are different CR-like types,depending on the membrane patch size of the neuron.For a smaller patch size,only single CR-like behavior occurs;while for a larger patch size,coherence bi-resonance-like (CBR) behavior appears.These findings show that the delay-induced CR-like behavior is closely related to the channel noise strength,and the coupled neurons may exhibit different spiking behaviors under the interplay of the channel noise and time delay.Therefore,the channel noise should be taken into account in the study of time delay-related spiking activity in stochastic HH neurons.This work provides new insight into the role of channel noise and information transmission delays in realistic neural systems.

  1. Effect of autaptic activity on the response of a Hodgkin-Huxley neuron

    Science.gov (United States)

    Wang, Hengtong; Wang, Longfei; Chen, Yueling; Chen, Yong

    2014-09-01

    An autapse is a special synapse that connects a neuron to itself. In this study, we investigated the effect of an autapse on the responses of a Hodgkin-Huxley neuron to different forms of external stimuli. When the neuron was subjected to a DC stimulus, the firing frequencies and the interspike interval distributions of the output spike trains showed periodic behaviors as the autaptic delay time increased. When the input was a synaptic pulse-like train with random interspike intervals, we observed low-pass and band-pass filtering behaviors. Moreover, the region over which the output ISIs are distributed and the mean firing frequency display periodic behaviors with increasing autaptic delay time. When specific autaptic parameters were chosen, most of the input ISIs could be filtered, and the response spike trains were nearly regular, even with a highly random input. The background mechanism of these observed dynamics has been analyzed based on the phase response curve method. We also found that the information entropy of the output spike train could be modified by the autapse. These results also suggest that the autapse can serve as a regulator of information response in the nervous system.

  2. A study of quantum mechanical probabilities in the classical Hodgkin-Huxley model.

    Science.gov (United States)

    Moradi, N; Scholkmann, F; Salari, V

    2015-03-01

    The Hodgkin-Huxley (HH) model is a powerful model to explain different aspects of spike generation in excitable cells. However, the HH model was proposed in 1952 when the real structure of the ion channel was unknown. It is now common knowledge that in many ion-channel proteins the flow of ions through the pore is governed by a gate, comprising a so-called "selectivity filter" inside the ion channel, which can be controlled by electrical interactions. The selectivity filter (SF) is believed to be responsible for the selection and fast conduction of particular ions across the membrane of an excitable cell. Other (generally larger) parts of the molecule such as the pore-domain gate control the access of ions to the channel protein. In fact, two types of gates are considered here for ion channels: the "external gate", which is the voltage sensitive gate, and the "internal gate" which is the selectivity filter gate (SFG). Some quantum effects are expected in the SFG due to its small dimensions, which may play an important role in the operation of an ion channel. Here, we examine parameters in a generalized model of HH to see whether any parameter affects the spike generation. Our results indicate that the previously suggested semi-quantum-classical equation proposed by Bernroider and Summhammer (BS) agrees strongly with the HH equation under different conditions and may even provide a better explanation in some cases. We conclude that the BS model can refine the classical HH model substantially.

  3. Stochastic resonance on Newman-Watts networks of Hodgkin-Huxley neurons with local periodic driving

    Energy Technology Data Exchange (ETDEWEB)

    Ozer, Mahmut [Zonguldak Karaelmas University, Engineering Faculty, Department of Electrical and Electronics Engineering, 67100 Zonguldak (Turkey)], E-mail: mahmutozer2002@yahoo.com; Perc, Matjaz [University of Maribor, Faculty of Natural Sciences and Mathematics, Department of Physics, Koroska cesta 160, SI-2000 Maribor (Slovenia); Uzuntarla, Muhammet [Zonguldak Karaelmas University, Engineering Faculty, Department of Electrical and Electronics Engineering, 67100 Zonguldak (Turkey)

    2009-03-02

    We study the phenomenon of stochastic resonance on Newman-Watts small-world networks consisting of biophysically realistic Hodgkin-Huxley neurons with a tunable intensity of intrinsic noise via voltage-gated ion channels embedded in neuronal membranes. Importantly thereby, the subthreshold periodic driving is introduced to a single neuron of the network, thus acting as a pacemaker trying to impose its rhythm on the whole ensemble. We show that there exists an optimal intensity of intrinsic ion channel noise by which the outreach of the pacemaker extends optimally across the whole network. This stochastic resonance phenomenon can be further amplified via fine-tuning of the small-world network structure, and depends significantly also on the coupling strength among neurons and the driving frequency of the pacemaker. In particular, we demonstrate that the noise-induced transmission of weak localized rhythmic activity peaks when the pacemaker frequency matches the intrinsic frequency of subthreshold oscillations. The implications of our findings for weak signal detection and information propagation across neural networks are discussed.

  4. Effect of channel block on the collective spiking activity of coupled stochastic Hodgkin-Huxley neurons

    Institute of Scientific and Technical Information of China (English)

    GONG YuBing; XU Bo; MA XiaoGuang; HAN JiQu

    2008-01-01

    Toxins, such as tetraethylammonium (TEA) and tetrodotoxin (TTX), can make potassium or sodium ion channels poisoned, respectively, and hence reduce the number of working ion channels and lead to the diminishment of conductance. In this paper, we have studied by numerical simulations the effects of sodium and potassium ion channel poisoning on the collective spiking activity of an array of coupled stochastic Hodgkin-Huxley (HH) neurons. It is found for a given number of neurons sodium or potas-sium ion channel block can either enhance or reduce the collective spiking regularity, depending on the membrane patch size. For a given smaller or larger patch size, potassium and sodium ion channel block can reduce or enhance the collective spiking regularity, but they have different patch size ranges for the transformation. This result shows that sodium or potassium ion channel block might have dif-ferent effects on the collective spiking activity in coupled HH neurons from the effects for a single neuron, which represents the interplay among the diminishment of maximal conductance and the in-crease of channel noise strength due to the channel blocks, as well as the bi-directional coupling be-tween the neurons.

  5. Pseudo-Lyapunov exponents and predictability of Hodgkin-Huxley neuronal network dynamics.

    Science.gov (United States)

    Sun, Yi; Zhou, Douglas; Rangan, Aaditya V; Cai, David

    2010-04-01

    We present a numerical analysis of the dynamics of all-to-all coupled Hodgkin-Huxley (HH) neuronal networks with Poisson spike inputs. It is important to point out that, since the dynamical vector of the system contains discontinuous variables, we propose a so-called pseudo-Lyapunov exponent adapted from the classical definition using only continuous dynamical variables, and apply it in our numerical investigation. The numerical results of the largest Lyapunov exponent using this new definition are consistent with the dynamical regimes of the network. Three typical dynamical regimes-asynchronous, chaotic and synchronous, are found as the synaptic coupling strength increases from weak to strong. We use the pseudo-Lyapunov exponent and the power spectrum analysis of voltage traces to characterize the types of the network behavior. In the nonchaotic (asynchronous or synchronous) dynamical regimes, i.e., the weak or strong coupling limits, the pseudo-Lyapunov exponent is negative and there is a good numerical convergence of the solution in the trajectory-wise sense by using our numerical methods. Consequently, in these regimes the evolution of neuronal networks is reliable. For the chaotic dynamical regime with an intermediate strong coupling, the pseudo-Lyapunov exponent is positive, and there is no numerical convergence of the solution and only statistical quantifications of the numerical results are reliable. Finally, we present numerical evidence that the value of pseudo-Lyapunov exponent coincides with that of the standard Lyapunov exponent for systems we have been able to examine.

  6. To know eugenics and turn away eugenic mistake%认识优生学,走出优生的误区

    Institute of Scientific and Technical Information of China (English)

    陈基平

    2005-01-01

    目的正确认识何谓优生学.方法了解优生学的产生和发展过程,纠正社会上对优生的一些误解.结果优生优育不等同于"eugenics".结论优生是指通过保健、咨询、教育等手段,来帮助父母生出一个身心健康的孩子.

  7. Hitler's bible: an analysis of the relationship between American and German eugenics in pre-war Nazi Germany.

    Science.gov (United States)

    Brown, Susan

    2009-06-01

    Throughout the last century the wellbeing of those with disability has been threatened by the idea of eugenics. The most notable and extreme example of this could be considered to have been carried out during World WarTwo, within Nazi eugenic programmes. These resulted in the sterilisation and killing of hundreds of thousands of disabled people. Through research of a wide range of sources it has been established that much of the inspiration and encouragement for this rapidly progressing movement in Germany initially came from America, most notably from California. American eugenicists expressed interest, and at times jealousy, at the speed of the progression in German eugenics. German Sterilisation laws were drafted following careful study of American experiments and research, while financial support from a number of American individuals encouraged further German research. Correspondence between influential leaders, including Hitler, Grant and Whitney, Verschuer and Popenoe, on both sides also added to the developing relationship. In conclusion, although there are a number of vital differences between the progress of the eugenics programme in America and in pre-war Nazi Germany, and eugenics in America never produced the massive genocide that occurred in Germany, it is clear that the research, encouragement and enthusiasm from America had a profound influence on the rapidly growing Nazi eugenics movement.

  8. Comparison of the validity of Hill and Huxley muscle-tendon complex models using experimental data obtained from rat m. soleus in situ.

    Science.gov (United States)

    Lemaire, Koen K; Baan, Guus C; Jaspers, Richard T; van Soest, A J Knoek

    2016-04-01

    The relationship between mechanical and metabolic behaviour in the widely used Hill muscle-tendon complex (MTC) model is not straightforward, whereas this is an integral part of the Huxley model. In this study, we assessed to what extent Huxley- and Hill-type MTC models yield adequate predictions of mechanical muscle behaviour during stretch-shortening cycles (SSCs). In fully anaesthetized male Wistar rats (N=3), m. soleus was dissected completely free, except for the insertion. Cuff electrodes were placed over the n. ischiadicus. The distal end of the tendon was connected to a servo motor, via a force transducer. The setup allowed for full control over muscle stimulation and length, while force was measured. Quick-release and isovelocity contractions (part 1), and SSCs (part 2) were imposed. Simulations of part 2 were made with both a Hill and a Huxley MTC model, using parameter values determined from part 1. Modifications to the classic two-state Huxley model were made to incorporate series elasticity, activation dynamics, and active and passive force-length relationships. Results were similar for all rats. Fitting of the free parameters to the data of part 1 was near perfect (R(2)>0.97). During SSCs, predicted peak force and force during relaxation deviated from the experimental data for both models. Overall, both models yielded similarly adequate predictions of the experimental data. We conclude that Huxley and Hill MTC models are equally valid with respect to mechanical behaviour.

  9. From species ethics to social concerns: Habermas's critique of "liberal eugenics" evaluated.

    Science.gov (United States)

    Árnason, Vilhjálmur

    2014-10-01

    Three arguments of Habermas against "liberal eugenics" -- the arguments from consent, responsibility, and instrumentalization -- are critically evaluated and explicated in the light of his discourse ethics and social theory. It is argued that these arguments move partly at a too deep level and are in part too individualistic and psychological to sufficiently counter the liberal position that he sets out to criticize. This is also due to limitations that prevent discourse ethics from connecting effectively to the moral and political domains, e.g., through a discussion of justice. In spite of these weaknesses, Habermas's thesis is of major relevance and brings up neglected issues in the discussion about eugenic reproductive practices. This relevance has not been duly recognized in bioethics, largely because of the depth of his speculations of philosophical anthropology. It is argued that Habermas's notion of the colonization of the lifeworld could provide the analytical tool needed to build that bridge to the moral and political domain.

  10. 'These pushful days': time and disability in the age of eugenics.

    Science.gov (United States)

    Baynton, Douglas C

    2011-01-01

    At the turn of the twentieth century, social attitudes toward disability turned sharply negative. An international eugenics movement brought about restrictive immigration laws in the United States and other immigrant nations. One cause was the changing understanding of time, both historical and quotidian, that accompanied the advent of evolutionary theory and a competitive industrial economy. As analogies of competition became culturally ubiquitous, new words to talk about disability such as 'handicapped', 'retarded', 'abnormal', 'degenerate', and 'defective', came into everyday use, all of them explicitly or implicitly rooted in new ways of thinking about time. The intense fear of disability that characterised the eugenics movement grew, in good part, from this new and unsettling vision of time.

  11. From political economy to sociology: Francis Galton and the social-scientific origins of eugenics.

    Science.gov (United States)

    Renwick, Chris

    2011-09-01

    Having coined the word 'eugenics' and inspired leading biologists and statisticians of the early twentieth century, Francis Galton is often studied for his contributions to modern statistical biology. However, whilst documenting this part of his work, historians have frequently neglected crucial aspects of what motivated Galton to establish his eugenics research programme. Arguing that his work was shaped more by social than by biological science, this paper addresses these oversights by tracing the development of Galton's programme, from its roots in a debate about political economy to his appeals for it to be taken up by sociologists. In so doing, the paper not only returns Galton's ideas to their original context but also provides a reason to reflect on the place of the social sciences in history-of-science scholarship.

  12. [The 100-year anniversary of Eugene Jamot's (1879-1937) admittance to the Pharo School].

    Science.gov (United States)

    Milleliri, J M; Louis, F J

    2010-04-01

    For the 100-year anniversary of Dr. Eugene Jamot's (1879-1937) admittance to the Pharo School (then known as the Training School of the Colonial Army Health Corps), the authors describe the life of a French military physician working in Africa. Eugene Jamot devoted 22 years of his life to fighting sleeping sickness. Using a standardized approach that has become a textbook example, he was highly successful in controlling this dreaded tropical disease. Despite being criticized by some officials of the colonial administration and becoming the target of an obvious smear campaign because of his strong personality and growing fame, Jamot handed down a set of values that are recognized by most physicians working to improve the living conditions of the unfortunately still suffering African population.

  13. A gift of prophecy essays in celebration of the life of Robert Eugene Marshak

    CERN Document Server

    1994-01-01

    Robert Eugene Marshak (1916-92) devoted much of his life to helping other people carry out scientific research and gather to discuss their work. In addition to his scientific statesmanship, he was an extraordinarily gifted research scientist, and many of his scientific contributions have been prophetic. This book pays homage to his creativity and continuing work, with contributions from many of the people whose lives have been influenced by him.

  14. [Eugenics' extension in the Spanish health care system through the prenatal diagnosis].

    Science.gov (United States)

    Rodríguez Martín, Esteban

    2012-01-01

    The wide implantation of strategies of sifted or prenatal selection close to laws that protect the destruction of the human life before the childbirth in the whole world, they are giving place to an increasing number of eugenic abortions. In Spain, the law 2/2010 of the sexual and reproductive health and voluntary interruption of pregnancy there has supposed the liberalization of the eugenic abortion without term limit. In we make concrete, the sanitary national and international policies of prenatal selection of Down's Syndrome, which they chase to facilitate the total or partial destruction before the childbirth of this human group, submitting it to a few particular conditions of existence during his prenatal life in those who will be an object of a series of technologies of selection, they might be qualified of genocidal policies if we consider the definition of genocide given by United Nations. In consequence, the sanitary agent who takes part without objection in the above mentioned programs promoted by the principal agents, meets turned into a necessary cooperator of the abortion who justifies itself in the supposition of "foetal risk". We can conclude that we are present at an eugenic drift of the prenatal diagnosis that is opposite to the ethical beginning of the medical profession.

  15. The doers of good. Scandinavian historians revise the social history of eugenics(1997-2001).

    Science.gov (United States)

    Zylberman, Patrick

    2008-01-01

    Late disclosure of the large scale of sterilization practices in the Nordic countries created an outburst of scandal: did these policies rely on coercion? To what extent? Who in the end was responsible? Sterilization practices targeted underprivileged people first. The mentally retarded and women were their first victims. Operations were very frequently determined by other people's manipulative or coercive influences. Should the blame be put on the Social-Democrats in power throughout the period (except in Finland and Estonia)? Apart from Denmark, perhaps, local physicians and local services, more than governments, seemed to have strongly supported sterilization practices. Teetotalers and feminists shared responsibilities. How can one explain that eugenics finally declined? Based on a sound application of the Hardy-Weinberg law, the science of the eugenicists was correct. Was it politics? But uncovering of the Nazi crimes had only a very small impact on eugenics. Some authors underline the fact that the Nordic scientific institutions were particularly suited to liberal values. Others point to the devastating effect on eugenics once hereditarist psychiatry fell from favor in the middle of the sixties.

  16. Eugenic World Building and Disability: The Strange World of Kazuo Ishiguro's Never Let Me Go.

    Science.gov (United States)

    Garland-Thomson, Rosemarie

    2017-06-01

    A crucial challenge for critical disability studies is developing an argument for why disabled people should inhabit our democratic, shared public sphere. The ideological and material separation of citizens into worthy and unworthy based on physiological variations imagined as immutable differences is what I call eugenic world building. It is justified by the idea that social improvement and freedom of choice require eliminating devalued human traits in the interest of reducing human suffering, increasing life quality, and building a more desirable citizenry. In this essay, I outline the logic of inclusive and eugenic world building, define and explain the role of the "normate" in eugenic logic, and provide a critical disability studies reading of the 2005 novel Never Let Me Go by Kazuo Ishiguro and its 2010 film adaptation. I argue that the ways of being in the world we think of as disabilities must be understood as the natural variations, abilities, and limitations inherent in human embodiment. When this happens, disability will be understood not as a problem to be eliminated but, rather, as a valid way of being in the world that must be accommodated through a sustaining and sustainable environment designed to afford access for a wide range of human variations.

  17. Stochastic differential equation models for ion channel noise in Hodgkin-Huxley neurons.

    Science.gov (United States)

    Goldwyn, Joshua H; Imennov, Nikita S; Famulare, Michael; Shea-Brown, Eric

    2011-04-01

    The random transitions of ion channels between conducting and nonconducting states generate a source of internal fluctuations in a neuron, known as channel noise. The standard method for modeling the states of ion channels nonlinearly couples continuous-time Markov chains to a differential equation for voltage. Beginning with the work of R. F. Fox and Y.-N. Lu [Phys. Rev. E 49, 3421 (1994)], there have been attempts to generate simpler models that use stochastic differential equation (SDEs) to approximate the stochastic spiking activity produced by Markov chain models. Recent numerical investigations, however, have raised doubts that SDE models can capture the stochastic dynamics of Markov chain models.We analyze three SDE models that have been proposed as approximations to the Markov chain model: one that describes the states of the ion channels and two that describe the states of the ion channel subunits. We show that the former channel-based approach can capture the distribution of channel noise and its effects on spiking in a Hodgkin-Huxley neuron model to a degree not previously demonstrated, but the latter two subunit-based approaches cannot. Our analysis provides intuitive and mathematical explanations for why this is the case. The temporal correlation in the channel noise is determined by the combinatorics of bundling subunits into channels, but the subunit-based approaches do not correctly account for this structure. Our study confirms and elucidates the findings of previous numerical investigations of subunit-based SDE models. Moreover, it presents evidence that Markov chain models of the nonlinear, stochastic dynamics of neural membranes can be accurately approximated by SDEs. This finding opens a door to future modeling work using SDE techniques to further illuminate the effects of ion channel fluctuations on electrically active cells.

  18. Power-Law Dynamics of Membrane Conductances Increase Spiking Diversity in a Hodgkin-Huxley Model.

    Science.gov (United States)

    Teka, Wondimu; Stockton, David; Santamaria, Fidel

    2016-03-01

    We studied the effects of non-Markovian power-law voltage dependent conductances on the generation of action potentials and spiking patterns in a Hodgkin-Huxley model. To implement slow-adapting power-law dynamics of the gating variables of the potassium, n, and sodium, m and h, conductances we used fractional derivatives of order η≤1. The fractional derivatives were used to solve the kinetic equations of each gate. We systematically classified the properties of each gate as a function of η. We then tested if the full model could generate action potentials with the different power-law behaving gates. Finally, we studied the patterns of action potential that emerged in each case. Our results show the model produces a wide range of action potential shapes and spiking patterns in response to constant current stimulation as a function of η. In comparison with the classical model, the action potential shapes for power-law behaving potassium conductance (n gate) showed a longer peak and shallow hyperpolarization; for power-law activation of the sodium conductance (m gate), the action potentials had a sharp rise time; and for power-law inactivation of the sodium conductance (h gate) the spikes had wider peak that for low values of η replicated pituitary- and cardiac-type action potentials. With all physiological parameters fixed a wide range of spiking patterns emerged as a function of the value of the constant input current and η, such as square wave bursting, mixed mode oscillations, and pseudo-plateau potentials. Our analyses show that the intrinsic memory trace of the fractional derivative provides a negative feedback mechanism between the voltage trace and the activity of the power-law behaving gate variable. As a consequence, power-law behaving conductances result in an increase in the number of spiking patterns a neuron can generate and, we propose, expand the computational capacity of the neuron.

  19. Comparison between Hodgkin-Huxley and Markov formulations of cardiac ion channels.

    Science.gov (United States)

    Carbonell-Pascual, Beatriz; Godoy, Eduardo; Ferrer, Ana; Romero, Lucia; Ferrero, Jose M

    2016-06-21

    When simulating the macroscopic current flowing through cardiac ion channels, two mathematical formalisms can be adopted: the Hodgkin-Huxley model (HHM) formulation, which describes openings and closings of channel 'gates', or the Markov model (MM) formulation, based on channel 'state' transitions. The latter was first used in 1995 to simulate the effects of mutations in ionic currents and, since then, its use has been extended to wild-type channels also. While the MMs better describe the actual behavior of ion channels, they are mathematically more complex than HHMs in terms of parameter estimation and identifiability and are computationally much more demanding, which can dramatically increase computational time in large-scale (e.g. whole heart) simulations. We hypothesize that a HHM formulation obtained from classical patch-clamp protocols in wild-type and mutant ion channels can be used to correctly simulate cardiac action potentials and their static and dynamic properties. To validate our hypothesis, we selected two pivotal cardiac ionic currents (the rapid delayed rectifier K(+) current, IKr, and the inward Na(+) current, INa) and formulated HHMs for both wild-type and mutant channels (LQT2-linked T474I mutation for IKr and LQT3-linked ΔKPQ mutation for INa). Action potentials were then simulated using the MM and HHM versions of the currents, and the action potential waveforms, biomarkers and action potential duration rate dependence properties were compared in control conditions and in the presence of physiological variability. While small differences between ionic currents were found between the two models (correlation coefficient ρ>0.92), the simulations yielded almost identical action potentials (ρ>0.99), suggesting that HHMs may also be valid to simulate the effects of mutations affecting IKr and INa on the action potential.

  20. Power-Law Dynamics of Membrane Conductances Increase Spiking Diversity in a Hodgkin-Huxley Model.

    Directory of Open Access Journals (Sweden)

    Wondimu Teka

    2016-03-01

    Full Text Available We studied the effects of non-Markovian power-law voltage dependent conductances on the generation of action potentials and spiking patterns in a Hodgkin-Huxley model. To implement slow-adapting power-law dynamics of the gating variables of the potassium, n, and sodium, m and h, conductances we used fractional derivatives of order η≤1. The fractional derivatives were used to solve the kinetic equations of each gate. We systematically classified the properties of each gate as a function of η. We then tested if the full model could generate action potentials with the different power-law behaving gates. Finally, we studied the patterns of action potential that emerged in each case. Our results show the model produces a wide range of action potential shapes and spiking patterns in response to constant current stimulation as a function of η. In comparison with the classical model, the action potential shapes for power-law behaving potassium conductance (n gate showed a longer peak and shallow hyperpolarization; for power-law activation of the sodium conductance (m gate, the action potentials had a sharp rise time; and for power-law inactivation of the sodium conductance (h gate the spikes had wider peak that for low values of η replicated pituitary- and cardiac-type action potentials. With all physiological parameters fixed a wide range of spiking patterns emerged as a function of the value of the constant input current and η, such as square wave bursting, mixed mode oscillations, and pseudo-plateau potentials. Our analyses show that the intrinsic memory trace of the fractional derivative provides a negative feedback mechanism between the voltage trace and the activity of the power-law behaving gate variable. As a consequence, power-law behaving conductances result in an increase in the number of spiking patterns a neuron can generate and, we propose, expand the computational capacity of the neuron.

  1. Comments on Eugene Thacker’s “Cosmic Pessimism”

    Directory of Open Access Journals (Sweden)

    Nicola Masciandaro

    2012-08-01

    Full Text Available In the interest of promoting a concentrated, constructive interaction between the author of an article and commentators on a topic judged to be of broad significance to the community, continent. welcomes proposals for Open Peer Commentary. All authors interested in writing a commentary are advised to review our policy.

  2. Human heredity and politics: A comparative institutional study of the Eugenics Record Office at Cold Spring Harbor (United States), the Kaiser Wilhelm Institute for Anthropology, Human Heredity, and Eugenics (Germany), and the Maxim Gorky Medical Genetics Institute (USSR).

    Science.gov (United States)

    Adams, Mark B; Allen, Garland E; Weiss, Sheila Faith

    2005-01-01

    Despite the fact that much has been written in recent years about the science of heredity under the Third Reich, there is as yet no satisfying analysis of two central questions: What, if anything, was peculiarly "Nazi" about human genetics under National Socialism? How, under whatever set of causes, did at least some of Germany's most well-known and leading biomedical practioners become engaged in entgrenzte Wissenschaft (science without moral boundaries)? This paper attempts to provide some answers to these two questions comparing three institutes that studied eugenics and human heredity in the 1920s and 1930s: the Eugenics Record Office at Cold Spring Harbor, New York, directed by Charles B. Davenport; the Kaiser Wilhelm Institute for Anthropology, Human Heredity and Eugenics, in Berlin, directed by Eugen Fischer; and the Maxim Gorky Medical Genetics Institute in Moscow, directed by Solomon G. Levit. The institutes are compared on the basis of the kind and quality of their research in eugenics and medical genetics, organizational structure, leadership, patronage (private or state), and the economic-social-political context in which they functioned.

  3. Hodgkin-Huxley revisited: reparametrization and identifiability analysis of the classic action potential model with approximate Bayesian methods.

    Science.gov (United States)

    Daly, Aidan C; Gavaghan, David J; Holmes, Chris; Cooper, Jonathan

    2015-12-01

    As cardiac cell models become increasingly complex, a correspondingly complex 'genealogy' of inherited parameter values has also emerged. The result has been the loss of a direct link between model parameters and experimental data, limiting both reproducibility and the ability to re-fit to new data. We examine the ability of approximate Bayesian computation (ABC) to infer parameter distributions in the seminal action potential model of Hodgkin and Huxley, for which an immediate and documented connection to experimental results exists. The ability of ABC to produce tight posteriors around the reported values for the gating rates of sodium and potassium ion channels validates the precision of this early work, while the highly variable posteriors around certain voltage dependency parameters suggests that voltage clamp experiments alone are insufficient to constrain the full model. Despite this, Hodgkin and Huxley's estimates are shown to be competitive with those produced by ABC, and the variable behaviour of posterior parametrized models under complex voltage protocols suggests that with additional data the model could be fully constrained. This work will provide the starting point for a full identifiability analysis of commonly used cardiac models, as well as a template for informative, data-driven parametrization of newly proposed models.

  4. A laboratory for Latin eugenics: the Italian Committee for the Study of Population Problems and the international circulation of eugenic knowledge, 1920s-1940s

    Directory of Open Access Journals (Sweden)

    Luc André Berlivet

    Full Text Available Abstract The aim of this article is to shed light on the rise to international prominence of the Italian statistician and eugenicist Corrado Gini and his appointment as the inaugural president of the Latin International Federation of Eugenic Societies in October 1935. It explores the numerous pioneering, still little known, investigations he undertook with a few Italian scientists and some foreign scholars, in order to analyze the role played by “isolation,” and “racial hybridization” in the formation and degeneration of human races. After outlining Gini’s professional and political trajectory, the article focuses on the scientific expeditions launched by the Italian Committee for the Study of Population Problems between 1933 and 1940 under his stewardship.

  5. Inherently Undesirable: American Identity and the Role of Negative Eugenics in the Education of Visually Impaired and Blind Students in Ohio, 1870-1930

    Science.gov (United States)

    Free, Jennifer L.

    2012-01-01

    To date, studies of eugenics artificially confine their focus to the movement's application to race, socio-economic status, and the forced sterilization of the so-called feebleminded. However, the segregationist aspect of the eugenics design in the United States brought with it damaging policies toward individuals with physical and mental…

  6. Eugenics and migration: a case study of Salvation Army literature about Canada and Britain, c.1890-1921.

    Science.gov (United States)

    Baker, Graham J

    2014-01-01

    The eugenics movement attracted a wide range of supporters. This article explores this theme with relation to literature about the charitable work of the Salvation Army in Britain and Canada c.1890-1921, with a focus upon the emigration scheme outlined in William Booth's book In Darkest England and the Way Out. These writings indicate the widespread dispersal of eugenic ideology, and demonstrate the flexibility with which these theories were interpreted in this period. It will be shown that the Salvation Army adopted elements of both hereditarian and environmentalist views regarding racial health. These arguments were unified by the claim that the work of the organization made a worthy contribution to public health, both in the present and in the future. This case study sheds new light upon the history of a prominent evangelical Christian organization and upon the development of the international eugenics movement.

  7. Eugenics as Indian removal: sociohistorical processes and the de(con)struction of American Indians in the southeast.

    Science.gov (United States)

    Gonzales, Angela; Kertész, Judy; Tayac, Gabrielle

    2007-01-01

    Although research on the history of the eugenics movement in the United States is legion, its impact on state policies that identified and defined American Indians has yet to be fully addressed. The exhibit, Our Lives: Comtemporary Life and Identities (ongoing until September 21, 2014) at the National Museum of the American Indian provides a provocative vehicle for examining how eugenics-informed public policy during the first quarter of the twentieth century served to "remove" from official records Native peoples throughout the Southeast. One century after Indian Removal of the antebellum era, Native peoples in the American Southeast provide an important but often overlooked example of how racial policies, this time rooted in eugenics, effected a documentary erasure of Native peoples and communities.

  8. Attitude and opinion of volunteer blood donors regarding access to eugenic

    Directory of Open Access Journals (Sweden)

    Konstantina Chatzilaou

    2009-02-01

    Full Text Available PURPOSE: The assessment of the attitude and views of blood donors in relation to eugenics. As well as the relation of eugenics to several demographical factors such as educational level, sex age and religious beliefs.MATERIAL AND METHOD: The subjects of study were 252 blood donors, who voluntarily gave blood and its byproducts in a Blood Donation Center in Athens. The data was collected through an anonymous questionnaire especially designed for the purpose of this study.RESULTS: The overwhelming majority of volunteer blood-donors agree in percentage greater than 50%, that society will probably never offer sufficient support to individuals with disabilities and that a woman should be submitted to prenatal control to determine if she medically advised in relation to her age and family background. 79% agrees that they would want to learn more about the moral questions that arise from the application of genetics to human.Independent variables that influence the attitude towards eugenics were found to be the importance of religion, the level of education, the sex and the number of children.Also, there was a connection of religion and the number of children with the knowledge of moral questions on genetics.CONCLUSIONS: Prenatal control should be carried out only when serious genetic illnesses or illnesses whose treatment is imperative to start early are expected. The attitude of citizens towards individuals with disabilities should change radically so that the biases and social stereotypes are raised. A better provision of information of the public on the moral questions that derive from the application of genetics to humans is also suggested.

  9. Eugene P. Wigner’s Visionary Contributions to Generations-I through IV Fission Reactors

    Directory of Open Access Journals (Sweden)

    Carré Frank

    2014-01-01

    Full Text Available Among Europe’s greatest scientists who fled to Britain and America in the 1930s, Eugene P. Wigner made instrumental advances in reactor physics, reactor design and technology, and spent nuclear fuel processing for both purposes of developing atomic weapons during world-war II and nuclear power afterwards. Wigner who had training in chemical engineering and self-education in physics first gained recognition for his remarkable articles and books on applications of Group theory to Quantum mechanics, Solid state physics and other topics that opened new branches of Physics.

  10. A paradigmatic disagreement in "Dialogue on Dialogic Pedagogy" by Eugene Matusov and Kiyotaka Miyazaki

    Directory of Open Access Journals (Sweden)

    Ana Marjanovic-Shane

    2014-10-01

    Full Text Available I read with a great pleasure the heated dialogue on Dialogic Pedagogy between Eugene Matusov and Kiyotaka Miyazaki. It provided me with one of those rare occasions where I could both witness, and also join, the workings of two minds as they struggled with and against each other to construct, de-construct, and reconstruct their visions of dialogic pedagogical approaches to education. As I was reading, I had a lot of questions and remarks. I try to summarize them here – while many are still left on the margins of the original manuscript.

  11. Eugene P. Wigner's Visionary Contributions to Generations-I through IV Fission Reactors

    Science.gov (United States)

    Carré, Frank

    2014-09-01

    Among Europe's greatest scientists who fled to Britain and America in the 1930s, Eugene P. Wigner made instrumental advances in reactor physics, reactor design and technology, and spent nuclear fuel processing for both purposes of developing atomic weapons during world-war II and nuclear power afterwards. Wigner who had training in chemical engineering and self-education in physics first gained recognition for his remarkable articles and books on applications of Group theory to Quantum mechanics, Solid state physics and other topics that opened new branches of Physics.

  12. Colombia en el contexto eugenésico latinoamericano 1900-1950

    Directory of Open Access Journals (Sweden)

    Juan Vianey Tovar Mosquera

    2016-01-01

    Full Text Available Introducción. La Eugenesia es un acontecimiento histórico que logró mover, una vez más, los fundamentos éticos tradicionales de la humanidad, cuestionando nuestra concepción de lo humano, haciendo de la diferencia, la debilidad o la enfermad una amenaza tangible urgente de normalizar o exterminar. Objetivo. Estudiar la forma como se desarrolló el movimiento eugenésico en Latinoamérica, en países como Argentina, Brasil, Colombia, Cuba, Chile, México y Perú. Materiales y métodos. Artículo de revisión de corte histórico; se seleccionó bibliografía que permitiera 1 brindar acercamiento al origen y principios de la Eugenesia; 2 investigaciones y artículos publicados en los países en mención que dan cuenta del desarrollo del movimiento eugenésico y de las políticas e instituciones con ocasión del mismo; 3 documentos históricos de intelectuales, políticos y educadores colombianos de la primera mitad del siglo XX para evaluar su adhesión al darwinismo social y al paradigma degeneracionista; 4 revisión de la legislación de la primera mitad del siglo XX en Colombia para analizar la materialización de principios eugenésicos y finalmente 5 se abordaron documentos que permiten consolidar una reflexión en torno a los graves problemas éticos y sociales que implicó la Eugenesia como un paradigma determinista biológica y socialmente. Resultados y discusión. Se evidencia que el movimiento eugenésico permeó el contexto latinoamericano definiendo, en la primera mitad del siglo XX, la política pública de los diferentes estados en materia educativa, médica, económica y migratoria, entre otras; generando graves problemas de estigmatización racial y moral.

  13. [Towards social eugenics. Ideology and bioethics in the construction of the social policy].

    Science.gov (United States)

    Fernández Riquelme, Sergio

    2009-01-01

    The social eugenics is the real face of the biomedical application of an ideological paradigm, self-styled like "progressive", that claims the radical transformation of the western society from laicist and utilitarians positions. This article tries to decipher the historical roots, the bioethical language and the political - social implications of this paradigm, which questions the essential dignity of any human life in benefit of "new rights", constructed ex professo. For it, it exposes three analytical dimensions of his "historical possibilities" (retrospective, perspective and Forward studies), taking as an example the role of the social Policy, and especially, the doctrinal and institutional paradoxes of the "Welfare state" in Spain.

  14. Contraception or eugenics? Sterilization and "mental retardation" in the 1970s and 1980s.

    Science.gov (United States)

    Ladd-Taylor, Molly

    2014-01-01

    Nonconsensual sterilization is usually seen as the by-product of a classist and racist society; disability is ignored. This article examines the 1973 sterilization of two young black girls from Alabama and other precedent-setting court cases involving the sterilization of "mentally retarded" white women to make disability more central to the historical analysis of sterilization. It analyzes the concept of mental retardation and the appeal of a surgical solution to birth control, assesses judicial deliberations over the "right to choose" contraceptive sterilization when the capacity to consent is in doubt, and reflects on the shadow of eugenics that hung over the sterilization debate in the 1970s and 1980s.

  15. The reception of Eugen Bleuler in British psychiatry, 1892-1954.

    LENUS (Irish Health Repository)

    Dalzell, Thomas

    2012-02-01

    This article draws on over 60 years of British medical journals and psychiatry textbooks to indicate the chronological stages of the reception of Eugen Bleuler in British psychiatry. Bleuler was already well known in Britain before his schizophrenia book appeared, with the journals containing numerous references, mainly positive, to his work. The psychiatry textbooks, however, were slower to integrate his contribution. This paper argues that this was not due to Bleuler\\'s placing Freud on a par with Kraepelin, but because of the early negative reaction to Kraepelin\\'s dementia praecox concept, despite Bleuler\\'s wider and less ominous conception of the illness.

  16. From the 'Village of a Thousand Souls' to 'Race Crossing in Jamaica': Arnold Gesell, eugenics and child development.

    Science.gov (United States)

    Weizmann, Fredric

    2010-01-01

    Perhaps best known for providing age-related norms in early development, norms that are still used as a basis for measures of developmental maturity, Arnold Gesell was a key figure in developmental psychology from the 1920s through the 1950s. After examining Gesell's reputation and status in the field, we explore Gesell's changing relationship to eugenics, both in terms of Gesell's often contradictory attitudes about the role of hereditary and environmental influences in development, and in terms of the broader relationship between the eugenics movement and science.

  17. [Eugenic abortion could explain the lower infant mortality in Cuba compared to that in Chile].

    Science.gov (United States)

    Donoso S, Enrique; Carvajal C, Jorge A

    2012-08-01

    Cuba and Chile have the lower infant mortality rates of Latin America. Infant mortality rate in Cuba is similar to that of developed countries. Chilean infant mortality rate is slightly higher than that of Cuba. To investigate if the lower infant mortality rate in Cuba, compared to Chile, could be explained by eugenic abortion, considering that abortion is legal in Cuba but not in Chile. We compared total and congenital abnormalities related infant mortality in Cuba and Chile during 2008, based on vital statistics of both countries. In 2008, infant mortality rates in Chile were significantly higher than those of Cuba (7.8 vs. 4.7 per 1,000 live born respectively, odds ratio (OR) 1.67; 95% confidence intervals (Cl) 1.52-1.83). Congenital abnormalities accounted for 33.8 and 19.2% of infant deaths in Chile and Cuba, respectively. Discarding infant deaths related to congenital abnormalities, infant mortality rate continued to be higher in Chile than in Cuba (5.19 vs. 3.82 per 1000 live born respectively, OR 1.36; 95%CI 1.221.52). Considering that antenatal diagnosis is widely available in both countries, but abortion is legal in Cuba but not in Chile, we conclude that eugenic abortion may partially explain the lower infant mortality rate observed in Cuba compared to that observed in Chile.

  18. Racial Metabolism: Eugenic Studies in Jamaica and Yucatán, between 1920 and 1940

    Directory of Open Access Journals (Sweden)

    Joel Vargas Domínguez

    2015-10-01

    Full Text Available Objective: this paper shows the configuration of research conducted by the Carnegie Institution of Washington (CIW, in Jamaica and Yucatan, about basal metabolism on the onset of the twen­tieth century. I argue that this physiological research, conducted outside the usual laboratory spaces, used and articulated eugenics and racialized notions about the bodies under examination.Content: from the standpoint of the history of science I have analyzed the publications, reports and correspondence of the members of the Carnegie Institution expeditions. Conclusions: I show that basal metabolism was a measure constructed and used in the first half of the twentieth cen­tury with a strong eugenic and racial bias. Francis G. Benedict, Charles B. Davenport and Morris Steggerda from the CIW conducted these expeditions not only from the medical but also from the anthropological standpoint, in order to answer the question whether there was a climatic or racial effect on the body of the subjects analyzed. The results of the research were incorporated to the formulas used to evaluate the nutritional status of populations, fact that might have con­sequences nowadays on the way we understand metabolic “normality”.

  19. From eugenics to lysenkoism: the evolution of Stanisław Skowron.

    Science.gov (United States)

    Dejong-Lambert, William

    2009-01-01

    This article describes the relationship between Polish geneticist Stanisław Skowron's views on eugenics during the interwar period, his experiences in Nazi concentration camps during World War II, and his response to Trofim D. Lysenko's ban on genetic research in Soviet-allied states after 1948. Skowron was educated at the Jagiellonian University in Krakow and received funding from the Rockefeller Foundation to study in the United States, Italy, Denmark, and Great Britain from 1924 to 1926. His exposure to research being conducted outside of Poland made him an important figure in Polish genetics. During this time Skowron also began to believe that an understanding of biological principles of heredity could play an important role in improving Polish society and became a supporter of eugenics. In 1939 he was arrested along with other faculty members at the Jagiellonian and sent to Sachsenhausen and Dachau. In 1947 he published the first book updating Polish biologists on recent developments in genetics; however, after learning of the outcome of the 1948 session of the Lenin All-Union Academy of Agricultural Sciences in Moscow, Skowron emerged as on of the most vocal advocates for Michurinism. I argue that Skowron's conversion to Lysenkoism was motivated by more than fear or opportunism, and is better understood as the product of his need to rationalize his own support for a theory he could not possibly have believed was correct.

  20. Energy consumption in Hodgkin–Huxley type fast spiking neuron model exposed to an external electric field

    Directory of Open Access Journals (Sweden)

    K. Usha

    2016-09-01

    Full Text Available This paper evaluates the change in metabolic energy required to maintain the signalling activity of neurons in the presence of an external electric field. We have analysed the Hodgkin–Huxley type conductance based fast spiking neuron model as electrical circuit by changing the frequency and amplitude of the applied electric field. The study has shown that, the presence of electric field increases the membrane potential, electrical energy supply and metabolic energy consumption. As the amplitude of applied electric field increases by keeping a constant frequency, the membrane potential increases and consequently the electrical energy supply and metabolic energy consumption increases. On increasing the frequency of the applied field, the peak value of membrane potential after depolarization gradually decreases as a result electrical energy supply decreases which results in a lower rate of hydrolysis of ATP molecules.

  1. Effect of gating currents of ion channels on the collective spiking activity of coupled Hodgkin-Huxley neurons

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Based on the coupled stochastic Hodgkin-Huxley neurons, we numerically studied the effect of gating currents of ion channels, as well as coupling and the number of neurons, on the collective spiking rate and regularity in the coupled system. It was found, for a given coupling strength and with a relatively large number of neurons, when gating currents are applied, the collective spiking regularity decreases; meanwhile, the collective spiking rate increases, indicating that gating currents can aggravate the de-synchronization of the spikings of all neurons. However, gating currents caused hardly any effect in the spiking of any individual neuron of the coupled system. This result, different from the reduction of the spiking rate by gating currents in a single neuron, provides a new insight into the effect of gating cur-rents on the global information processing and signal transduction in real neural systems.

  2. Derivation of Hodgkin-Huxley equations for a Na+ channel from a master equation for coupled activation and inactivation

    CERN Document Server

    Vaccaro, S R

    2016-01-01

    The Na+ current in nerve and muscle membranes may be described in terms of the activation variable m(t) and the inactivation variable h(t), which are dependent on the transitions of S4 sensors in each of the ion channel domains DI to DIV. The time-dependence of the Na+ current and the rate equations satisfied by m(t) and h(t) may be derived from the solution to a master equation which describes the coupling between two activation sensors regulating the Na+ channel conductance and a two stage inactivation process. The voltage dependence of the rate functions for inactivation and recovery from inactivation are consistent with the empirically determined Hodgkin-Huxley expressions, and exhibit saturation for both depolarized and hyperpolarized clamp potentials.

  3. Effects of the spike timing-dependent plasticity on the synchronisation in a random Hodgkin-Huxley neuronal network

    Science.gov (United States)

    Borges, R. R.; Borges, F. S.; Lameu, E. L.; Batista, A. M.; Iarosz, K. C.; Caldas, I. L.; Viana, R. L.; Sanjuán, M. A. F.

    2016-05-01

    In this paper, we study the effects of spike timing-dependent plasticity on synchronisation in a network of Hodgkin-Huxley neurons. Neuron plasticity is a flexible property of a neuron and its network to change temporarily or permanently their biochemical, physiological, and morphological characteristics, in order to adapt to the environment. Regarding the plasticity, we consider Hebbian rules, specifically for spike timing-dependent plasticity (STDP), and with regard to network, we consider that the connections are randomly distributed. We analyse the synchronisation and desynchronisation according to an input level and probability of connections. Moreover, we verify that the transition for synchronisation depends on the neuronal network architecture, and the external perturbation level.

  4. Effect of gating currents of ion channels on the collective spiking activity of coupled Hodξkin-Huxley neurons

    Institute of Scientific and Technical Information of China (English)

    GONG YuBing; XIE YanHang; XU Bo; MA XiaoGuang

    2009-01-01

    Based on the coupled stochastic Hodgkin-Huxley neurons, we numerically studied the effect of gating currents of ion channels, as well as coupling and the number of neurons, on the collective spiking rate and regularity in the coupled system, it was found, for a given coupling strength and with a relatively large number of neurons, when gating currents are applied, the collective spiking regularity decreases; meanwhile, the collective spiking rate increases, indicating that gating currents can aggravate the de-synchronization of the spikings of all neurons. However, gating currents caused hardly any effect in the spiking of any individual neuron of the coupled system. This result, different from the reduction of the spiking rate by gating currents in a single neuron, provides a new insight into the effect of gating cur-rents on the global information processing and signal transduction in real neural systems.

  5. Phase-locking and chaos in a silent Hodgkin-Huxley neuron exposed to sinusoidal electric field

    Energy Technology Data Exchange (ETDEWEB)

    Che Yanqiu [School of Electrical Engineering and Automation, Tianjin University, 300072 (China); Wang Jiang [School of Electrical Engineering and Automation, Tianjin University, 300072 (China)], E-mail: jiangwang@tju.edu.cn; Si Wenjie; Fei Xiangyang [School of Electrical Engineering and Automation, Tianjin University, 300072 (China)

    2009-01-15

    Neuronal firing patterns are related to the information processing in neural system. This paper investigates the response characteristics of a silent Hodgkin-Huxley neuron to the stimulation of externally-applied sinusoidal electric field. The neuron exhibits both p:q phase-locked (i.e. a periodic oscillation defined as p action potentials generated by q cycle stimulations) and chaotic behaviors, depending on the values of stimulus frequencies and amplitudes. In one-parameter space, a rich bifurcation structure including period-adding without chaos and phase-locking alternated with chaos suggests frequency discrimination of the neuronal firing patterns. Furthermore, by mapping out Arnold tongues, we partition the amplitude-frequency parameter space in terms of the qualitative behaviors of the neuron. Thus the neuron's information (firing patterns) encodes the stimulus information (amplitude and frequency), and vice versa.

  6. Effect of Autaptic Activity on Intrinsic Coherence Resonance in Newman-Watts Networks of Stochastic Hodgkin-Huxley Neurons

    Science.gov (United States)

    Wang, Qi; Gong, Yubing

    2016-06-01

    In this paper, we study the effect of autaptic activity on intrinsic coherence resonance (CR) induced by channel noise in Newman-Watts (NW) networks of stochastic Hodgkin-Huxley (HH) neurons. It is found that autaptic strength and autaptic delay have a big effect on the intrinsic CR. As autaptic strength increases, there is optimal autaptic strength by which the intrinsic CR is most highly enhanced. Autaptic delay can enhance, reduce, or destroy the intrinsic CR, depending on the delay length. Moreover, there are optimal coupling strength and network randomness by which autaptic activity can most highly enhance the intrinsic CR. These results show that autaptic activity has different effects on the intrinsic CR in the neuronal networks, and it can most highly enhance the intrinsic CR at optimal coupling strength and network randomness. These findings could find potential implications of channel noise and autaptic activity for the information processing and transmission in neural systems.

  7. Optimization of Intrinsic Stochastic Resonance in Adaptive Newman-Watts Network of Channel Blocked Hodgkin-Huxley Neurons

    Science.gov (United States)

    Wang, Qi; Gong, Yubing; Wu, Yanan

    2014-08-01

    In this paper, we study stochastic resonance (SR) induced by channel noise in adaptive weighted Newman-Watts networks of Hodgkin-Huxley neurons with channel blocking (CB). It is found that the intrinsic SR is dependent on adaptive coupling and is strongly enhanced when the changing rate of adaptive coupling is optimal, and this phenomenon is independent of sodium and potassium CB levels. As CB increases, the channel noise for SR decreases, but the strength of intrinsic SR nearly does not change in the presence of adaptive coupling, which is different from the case for fixed coupling. These results show that intrinsic SR can be enhanced and optimized by adaptive coupling, and CB's effect on the intrinsic SR can be reduced by adaptive coupling. This implies that adaptive coupling could more efficiently improve the time precision of information processing in neural systems.

  8. Two new species of South American freshwater crayfish genus Parastacus Huxley, 1879 (Crustacea: Decapoda: Parastacidae).

    Science.gov (United States)

    Ribeiro, Felipe Bezerra; Buckup, Ludwig; Gomes, Kelly Martinez; Araujo, Paula Beatriz

    2016-08-30

    Two new species of Parastacus Huxley, 1879 are described from material collected in the state of Rio Grande do Sul, southern Brazil: Parastacus fluviatilis sp. nov. from highland streams and Parastacus caeruleodactylus sp. nov. from wetlands. Parastacus fluviatilis sp. nov. is distinguished mainly by large chelipeds with dense setae cover on the cutting edge of fingers, telson subtriangular with two lateral blunt spines and strongly concave ventral surface of lateral process of thoracic sternites 6 and 7. Parastacus caeruleodactylus sp. nov. is distinguished mainly by blue cheliped fingers and a large gap between them, reduced abdomen, dorsal and ventral margins of dactylus, propodus and carpus of second pair of pereiopods with tufts of long setae and mid-dorsal carina of exopod of uropods unarmed. According to IUCN Red List criteria both species are considered endangered. Habitat characterization and a method for defining the shape of second abdominal pleura are also provided.

  9. A new species of Parastacus Huxley, 1879 (Crustacea, Decapoda, Parastacidae from a swamp forest in southern Brazil

    Directory of Open Access Journals (Sweden)

    Felipe Bezerra Ribeiro

    Full Text Available Abstract In this contribution we describe a new species of burrowing crayfish of the genus Parastacus Huxley, 1879 from a swamp forest in southern Brazil and determine its conservation status. The distinction of the new species is based on morphology and the mitochondrial DNA marker 16S rRNA. The extinction risk was assessed according to the sub-criterion B1 of IUCN that estimates the Extent of Occurrence (EOO. Parastacus tuerkayi sp. nov. is morphologically distinguishable from all species of Parastacus by having three lines of verrucous tubercles on the dorsomesial margin of the cheliped propodus and a suborbital angle exceeding 90°. The EOO comprises 647,674 km², and the species is classified as “endangered”. Phylogenetic relationships indicate the distinct position of this new species in relation to the already described species.

  10. Investigation of Eugenic Knowledge and Eugenic Health Service Demand among Popula-tion Planning to Get Pregnant%计划怀孕人群优生知识及优生保健服务需求调查

    Institute of Scientific and Technical Information of China (English)

    官燮; 李鹏

    2015-01-01

    目的:通过了解计划怀孕人群优生知识知晓现状和优生需求,为计划怀孕夫妇提供有针对性的孕前优生健康教育使和优生保健服务.方法于2013年6-8月期间,使用同一调查问卷对参与国家免费孕前优生健康检查项目的1003名参检人员进行调查.结果优生知识总得分不及格率70.1%,良好13.2%.调查对象中能正确回答孕期绝对不能使用的疫苗仅12.8%.不同年龄、不同文化程度调查对象对优生知识知晓情况比较差异有统计学意义(P <0.05).调查对象中根据自己意愿希望生育宝宝的占86.0%;能做到花很多精力在孩子身上的占89.6%;参检人员对优生服务的需求率较高(96.0%).结论在开展优生保健服务工作中,应加强指导和教育,有针对性地向育龄参检人群宣传优生保健知识.%Objectives To understand the awareness situation of eugenic knowledge and the demand of eugenic service among population planning to get pregnant,and to provide targeted eugenic knowledge and eugenic service for this population.Methods 1 003 objects who participated in the National Free Pregnant Eugenics Health Check Program were surveyed by using the same questionnaire from June to August in 2013.Results The failing rate of the eugenics knowledge was 70.1%,and the good grade rate was 13.2%.Only 12.8% of the objects could correctly answer which vaccines could not be used absolutely during pregnancy.The awareness status of eugenics knowledge was different among different age,different cultural level objects (P <0.05).86.0% of the objects wanted to give birth based on their own willing,and 89.6% of the objects could spend a lot of vigor on children.The demand rate of eugenic service was high (96.0%).Conclusions The guidance and the education should be strengthened in the work of eugenics health services,and the targeted eugenic knowledge should be spread for the childbearing age pop-ulation.

  11. Preserving Precious Instruments in Mathematics History: The Educational Museum of Teachers College and David Eugene Smith's Collection

    Science.gov (United States)

    Murray, Diane R.

    2011-01-01

    A history is given of the Educational Museum of Teachers College, which began in 1886, and David Eugene Smith's extensive collection of mathematical tools used in the Museum's exhibits is discussed. Historic mathematical instruments including, the astrolabe, abacus and counting rods, and the slide rule are examined. The author uses digitized…

  12. 76 FR 33341 - Notice of Intent to prepare a Resource Management Plan for the West Eugene Wetlands Planning Area...

    Science.gov (United States)

    2011-06-08

    ... costs of management. Preliminary planning criteria include: 1. Lands addressed in the RMP will be public... Bureau of Land Management Notice of Intent to prepare a Resource Management Plan for the West Eugene Wetlands Planning Area in the State of Oregon and Associated Environmental Impact Statement AGENCY: Bureau...

  13. Eugene O'Neill "Pikk päevatee kaob öösse" / Ellu Eik ; interv. Ene Paaver

    Index Scriptorium Estoniae

    Eik, Ellu

    2008-01-01

    Seoses Eesti Draamateatri suvelavastusega "Pikk päevatee kaob öösse" (autor Eugene O'Neill ja lavastaja Merle Karusoo) räägib Lääne-Tallinna Keskhaigla Sõltuvusravikeskuse psühhiaater Ellu Eik sõltuvuse tagamaadest ja mõjudest

  14. Eugene O'Neill "Pikk päevatee kaob öösse" / Ellu Eik ; interv. Ene Paaver

    Index Scriptorium Estoniae

    Eik, Ellu

    2008-01-01

    Seoses Eesti Draamateatri suvelavastusega "Pikk päevatee kaob öösse" (autor Eugene O'Neill ja lavastaja Merle Karusoo) räägib Lääne-Tallinna Keskhaigla Sõltuvusravikeskuse psühhiaater Ellu Eik sõltuvuse tagamaadest ja mõjudest

  15. 78 FR 21547 - Approval and Promulgation of Air Quality Implementation Plans; Oregon: Eugene-Springfield PM10

    Science.gov (United States)

    2013-04-11

    ..., children and older adults are the most likely to be affected by particle pollution exposure. However, even... a comprehensive wood burning curtailment program. EPA took final action to approve the State's... control measures in the Eugene- Springfield moderate PM 10 SIP include a mandatory home wood...

  16. Maltreatment of people with serious mental illness in the early 20th century: a focus on Nazi Germany and eugenics in America.

    Science.gov (United States)

    Fischer, Bernard A

    2012-12-01

    Prejudice and stigma against people with mental illness can be seen throughout history. The worst instance of this prejudice was connected to the rise of the eugenics movement in the early 20th century. Although the Nazi German T-4 program of killing people with mental illness was the most egregious culmination of this philosophy, the United States has its own dark eugenics history-nearing a slippery slope all too similar to that of the Nazis. Mental health care clinicians need to examine this period to honor the memory of the victims of eugenics and to guarantee that nothing like this will ever happen again.

  17. Science and culture in mid-Victorian Britain: the reviews, and William Crookes' Quarterly Journal of Science.

    Science.gov (United States)

    Knight, D

    1996-01-01

    Charles Darwin's Origin of Species was published in 1859, and we are often disposed to see it as marking an epoch in the struggle between religion and science. Recent analyses especially of the part played by T. H. Huxley, 'Darwin's bulldog', emphasise instead (or as well) Huxley's aim to exclude affable 'gentlemen of science' from what was becoming a profession for experts. Evidence from the Reviews of the period show that science accounted for some 10% of the articles; but also that demand for this very general literature was falling, as science and humanities indeed grew apart into what C.P. Snow later called 'two cultures'.

  18. "Our power to remodel civilization": the development of eugenic feminism in Alberta, 1909-1921.

    Science.gov (United States)

    Gibbons, Sheila

    2014-01-01

    In addition to being a prominent political figure in equal rights legislation, Emily Murphy was a vital contributor to programs which sought to improve the human race through forced sterilization. These negative aspects of this period in feminist history tend to be described as outside of the women's sphere, representing instead the patriarchal realm of men. However, both eugenics and the first-wave feminist ambitions for equal political rights were connected through an agrarian construction of "mothers of the race." As "mothers of the race," women in Alberta were responsible for the physical and moral betterment of the nation, and were directly engaged in concepts of intelligent motherhood, healthy childhood, and an overarching moral philosophy that was politically driven.

  19. A multilocus analysis provides evidence for more than one species within Eugenes fulgens (Aves: Trochilidae).

    Science.gov (United States)

    Zamudio-Beltrán, Luz E; Hernández-Baños, Blanca E

    2015-09-01

    The status of subspecies in systematic zoology is the focus of controversy. Recent studies use DNA sequences to evaluate the status of subspecies within species complexes and to recognize and delimit species. Here, we assessed the phylogenetic relationships, the taxonomic status of the proposed subspecies, and the species limits of the monotypic hummingbird genus Eugenes (E. fulgens with traditionally recognized subspecies E. f. fulgens, E. f. viridiceps, and E. f. spectabilis), using nuclear (Beta Fibrinogen BFib, Ornithine Decarboxylase ODC, and Muscle Skeletal Receptor Tyrosine Kinase MUSK) and mitochondrial (NADH dehydrogenase subunit 2 ND2, NADH dehydrogenase subunit 4 ND4, and Control Region CR) markers. We performed Bayesian and Bayesian Phylogenetics and Phylogeography analyses and found genetic differences between the three groups, suggesting the existence of two cryptic species (E. fulgens and E. viridiceps) and one phenotypically differentiated species (E. spectabilis). Our analyses show that the E. viridiceps and E. fulgens groups are more closely related with one another than with E. spectabilis.

  20. Eugenics and racial biology in Sweden and the USSR: contacts across the Baltic Sea.

    Science.gov (United States)

    Rudling, Per Anders

    2014-01-01

    The 1920s saw a significant exchange between eugenicists in Sweden and the young Soviet state. Sweden did not take part in World War I, and during the years following immediately upon the Versailles peace treaty, Swedish scholars came to serve as an intermediary link between, on the one hand, Soviet Russia and Weimar Germany, and, on the other hand, Western powers. Swedish eugenicists organized conferences, lecture tours, visits, scholarly exchanges, and transfers and translation of eugenic research. Herman Lundborg, the director of the world's first State Institute of Racial Biology, was an old-fashioned, deeply conservative, and anti-communist "scientific" racist, who somewhat paradoxically came to serve as something of a Western liaison for Soviet eugenicists. Whereas the contacts were disrupted in 1930, Swedish eugenicists had a lasting impact on Soviet physical anthropologists, who cited their works well into the 1970s, long after they had been discredited in Sweden.

  1. Border Gothic - history, violence and the border in the writings of Eugene McCabe

    Directory of Open Access Journals (Sweden)

    Éamonn Ó Ciardha

    2016-12-01

    Full Text Available As well as producing a rich body of novels, novellas, short-stories and plays spanning throughout seventy years of the century of partition, Eugene McCabe charts the broad trajectory of Irish history and politics from the Elizabethan Conquest and Ulster Plantation of the 16th and 17th centuries to the recent 'Troubles' which spanned the thirty years between the beginnings of the Civil Rights Movement (1968 and the signing of the Belfast/Good Friday Agreement (1998. They positively seethe with gruesome assassinations, indiscriminate bombings and deliberate shootings, while resonating with a veritable cacophony of deep-seeded ethnic rivalries and genocidal, religious hatreds, which are interlaced with poverty, social deprivation and dis-function, migration and emigration.

  2. "More than just boots! The eugenic and commercial concerns behind A. R. Kaufman's birth controlling activities".

    Science.gov (United States)

    Revie, Linda

    2006-01-01

    A. R. Kaufman (1885-1979), founder of the Kitchener-based Kaufman Rubber Company, was nicknamed "Canada's Mr. Birth Control" because he established the Parents' Information Bureau (PIB)-a birth control information centre that functioned out of his factory office. Besides creating mail order/home visiting services, Kaufman also funded birth control clinics. Because he was a rubber manufacturer, it was widely believed that commercial concerns were behind his activities. This article examines recently archived material, local newspaper accounts, and court transcripts to connect A. R. Kaufman and the PIB with the manufacture of contraceptive products. It also outlines Kaufman's involvement with the eugenics movement, especially his dealings with medical practitioners who carried out sterilization procedures for the PIB.

  3. Bogeria, eugenèsia i estadística amb Theodore M. Porter

    OpenAIRE

    Gil Farrero, Judit

    2014-01-01

    El Dr. Theodore M. Porter (University of California, Los Angeles) va impartir una xerrada titulada "Eugenic Madness: Asylums and the Data of Heredity" en el marc del cicle de col·loquis de la Societat Catalana d’Història de la Ciència i de la Tècnica (SCHCT) del curs 2013-2014, i amb la col·laboració del Centre d’Història de la Ciència (CEHIC-UAB). Porter és expert en la història de l’estadística i la quantificació en les ciències. En aquesta entrevista ens explica la relació entre els manico...

  4. Eugene Garfield and Algorithmic Historiography: Co-Words, Co-Authors, and Journal Names

    CERN Document Server

    Leydesdorff, Loet

    2010-01-01

    Algorithmic historiography was proposed by Eugene Garfield in collaboration with Irving Sher in the 1960s, but further developed only recently into HistCite^{TM} with Alexander Pudovkin. As in history writing, HistCite^{TM} reconstructs by drawing intellectual lineages. In addition to cited references, however, documents can be attributed a multitude of other variables such as title words, keywords, journal names, author names, and even full texts. New developments in multidimensional scaling (MDS) enable us not only to visualize these patterns at each moment of time, but also to animate them over time. Using title words, co-authors, and journal names in Garfield's oeuvre, the method is demonstrated and further developed in this paper (and in the animation at http://www.leydesdorff.net/garfield/animation). The variety and substantive content of the animation enables us to write, visualize, and animate the author's intellectual history.

  5. Eugene Onegin the Cold War Monument: How Edmund Wilson Quarreled with Vladimir Nabokov

    Directory of Open Access Journals (Sweden)

    Tim Conley

    2014-01-01

    Full Text Available The tale of how Edmund Wilson quarreled with Vladimir Nabokov over the latter’s 1964 translation of Eugene Onegin can be instructively read as a politically charged event, specifically a “high culture” allegory of the Cold War. Dissemination of anti-Communist ideals (often in liberal and literary guises was the mandate of the Congress for Cultural Freedom, whose funding and editorial initiatives included the publication of both pre-Revolution Russian literature and, more notoriously, the journal Encounter (1953-1990, where Nabokov’s fiery “Reply” to Wilson appeared. This essay outlines the propaganda value of the Onegin debate within and to Cold War mythology.

  6. [The early reception of the notion of schizophrenia of Eugen Bleuler in Austria].

    Science.gov (United States)

    Gabriel, Eberhard

    2012-01-01

    The 100th anniversary of Eugen Bleulers "Dementia praecox oder Gruppe der Schizophrenien" (Dementia praecox oder Gruppe der Schizophrenien. Leipzig: Deuticke; 1911) motivates a retrospective description of the early reception of the word and its meaning. It occurred in two phases: 1911-1914 (focus of that paper) and 1918-1929. The protagonists were Erwin Stransky (mainly in the first phase), Josef Berze (mainly in the second), Julius Wagner-Jauregg and Carl Meyer, leading motives criticisms of the further expansion of the earlier Kraepelinian notion of dementia praecox and of Bleulers' psychoanalytical interpreting of the disorder, but acceptance of the neologism 'schizophrenia' because of its meaning ("dissociative character") and the possibility to derive an adjective. The new word replaced the old denomination after world war I during the 1920s.

  7. Application of the (′/)-expansion method for the Burgers, Burgers–Huxley and modified Burgers–KdV equations

    Indian Academy of Sciences (India)

    H Kheiri; M R Moghaddam; V Vafaei

    2011-06-01

    In this work, we present travelling wave solutions for the Burgers, Burgers–Huxley and modified Burgers–KdV equations. The (′/)-expansion method is used to determine travelling wave solutions of these sets of equations. The travelling wave solutions are expressed by the hyperbolic functions, the trigonometric functions and the rational functions. It is shown that the proposed method is direct, effective and can be used for many other nonlinear evolution equations in mathematical physics.

  8. Refrigerator Mothers and Sick Little Boys: Bruno Bettelheim, Eugenics and the De-Pathologization of Jewish Identity

    Directory of Open Access Journals (Sweden)

    griffin jaye epstein

    2014-06-01

    Full Text Available Child psychologist and Nazi concentration camp survivor Bruno Bettelheim’s influential theories of autism reveal a startling connection between Jewish identity, the medicalization of disability, colonial eugenics and race-making practices over the 20th century in North America. Using Bettelheim’s life and work as a case-study, this paper explores Ashkenazi Jewish immigrant complicity in a whitened colonial landscape through the lens of Disability Studies. It asks the question: can we be more accountable to our disabled identities – and to those disabled people who have come before us – if we learn how our families, our identities, our very selves have been complicit in medicalization and violence?  Keywords: madness, race, whiteness, Jewish identity, eugenics, psychiatry

  9. A New Translation Theory of“Correspondency”and Its Difference from“Functional Equivalence”by Eugene A. Nida

    Institute of Scientific and Technical Information of China (English)

    何欣

    2015-01-01

    This paper puts forward a new translation theory of“correspondency”, which is a more comprehensive and systematic translation theory that is especially effective in the translation criticism of“English-Chinese”or“Chinese-English”, absorbing some merits from Eugene A. Nida’s“functional equivalence”. A comparison of these two translation theories are offered in the paper, in hope of enlightening the readers in one aspect or another.

  10. The Souls’Journey into Light--On Eugene O’Neill’s Long Days Journey into Night

    Institute of Scientific and Technical Information of China (English)

    万红芳

    2013-01-01

    This paper aims to find a glimmer of light and hope from Eugene O’Neill’s tragedy: Long Days Journey into Night. The Tyrones’ periodic quarrel from dawn to dark is a journey into torture whereas it can also been seen as an indication of the unremitting hope for home. Behind the uneasy tensions of the characters who still cry for individual salvation, lies a world where the conflict between reality and fantasy can be resolved through love and reconciliation.

  11. The analysis of the eugenic culture in ancient China%中国古代优生文化辨析

    Institute of Scientific and Technical Information of China (English)

    蒋功成; 宗红

    2010-01-01

    There was a centuries-old culture of eugenics in ancient China. We should have comprehensive and objective cognition of this tradition. The ancient people did not generally advocate marrying at a mature age as do people of modern times. They not only considered the prepotency, but also were influenced by other complicated social factors on the problem of mate selection. Although advocates of coition techniques claimed the purpose of prepotency, the eugenic effect of coition techniques deserved to be suspect. Regarding the aspect of embryo conservation and care, the most significant thing was not so-called"prenatal education", but various antenatal care methods which were proposed by TCM scholars. By making a comparison with modern eugenics, the ancient eugenics had the characteristics of valuing the male child only, commiserating with deformity and being based on familial values.%中国古代具有非常悠久的优生传统,对这种传统应有全面客观的认识.古人并非如今人所认为的那样普遍提倡晚婚;在择偶问题上古人既有优生的考虑,更受到其他复杂社会因素的影响;房中术的提倡者虽声称以优生为目的,但房中术的优生效果是值得怀疑的;在胚胎保育方面,真正有意义的不是所谓的"胎教",而是中医学者们所建议的各种"胎养"方法.与近现代优生学相比较,中国古代优生学还体现出重男轻女、同情残疾者、一切以家族繁衍为本位的特点.

  12. Effects of information transmission delay and channel blocking on synchronization in scale-free Hodgkin-Huxley neuronal networks

    Science.gov (United States)

    Wang, Qing-Yun; Zheng, Yan-Hong

    2011-12-01

    In this paper, we investigate the evolution of spatiotemporal patterns and synchronization transitions in dependence on the information transmission delay and ion channel blocking in scale-free neuronal networks. As the underlying model of neuronal dynamics, we use the Hodgkin-Huxley equations incorporating channel blocking and intrinsic noise. It is shown that delays play a significant yet subtle role in shaping the dynamics of neuronal networks. In particular, regions of irregular and regular propagating excitatory fronts related to the synchronization transitions appear intermittently as the delay increases. Moreover, the fraction of working sodium and potassium ion channels can also have a significant impact on the spatiotemporal dynamics of neuronal networks. As the fraction of blocked sodium channels increases, the frequency of excitatory events decreases, which in turn manifests as an increase in the neuronal synchrony that, however, is dysfunctional due to the virtual absence of large-amplitude excitations. Expectedly, we also show that larger coupling strengths improve synchronization irrespective of the information transmission delay and channel blocking. The presented results are also robust against the variation of the network size, thus providing insights that could facilitate understanding of the joint impact of ion channel blocking and information transmission delay on the spatiotemporal dynamics of neuronal networks.

  13. Teaching and learning the Hodgkin-Huxley model based on software developed in NEURON's programming language hoc.

    Science.gov (United States)

    Hernández, Oscar E; Zurek, Eduardo E

    2013-05-15

    We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a Hodgkin-Huxley (HH) axon to be changed. The aim of this work is to develop a didactic and easy-to-use computational tool in the NEURON simulation environment, which allows graphical visualization of both the passive and active conduction parameters and the geometric characteristics of a cylindrical axon with HH properties. The SENB software offers several advantages for teaching and learning electrophysiology. First, SENB offers ease and flexibility in determining the number of stimuli. Second, SENB allows immediate and simultaneous visualization, in the same window and time frame, of the evolution of the electrophysiological variables. Third, SENB calculates parameters such as time and space constants, stimuli frequency, cellular area and volume, sodium and potassium equilibrium potentials, and propagation velocity of the action potentials. Furthermore, it allows the user to see all this information immediately in the main window. Finally, with just one click SENB can save an image of the main window as evidence. The SENB software is didactic and versatile, and can be used to improve and facilitate the teaching and learning of the underlying mechanisms in the electrical activity of an axon using the biophysical properties of the squid giant axon.

  14. Derivation of Hodgkin-Huxley equations for a Na+ channel from a master equation for coupled activation and inactivation

    Science.gov (United States)

    Vaccaro, S. R.

    2016-11-01

    The Na+ current in nerve and muscle membranes may be described in terms of the activation variable m (t ) and the inactivation variable h (t ) , which are dependent on the transitions of S4 sensors of each of the Na+ channel domains DI to DIV. The time-dependence of the Na+ current and the rate equations satisfied by m (t ) and h (t ) may be derived from the solution to a master equation that describes the coupling between two or three activation sensors regulating the Na+ channel conductance and a two-stage inactivation process. If the inactivation rate from the closed or open states increases as the S4 sensors activate, a more general form of the Hodgkin-Huxley expression for the open-state probability may be derived where m (t ) is dependent on both activation and inactivation processes. The voltage dependence of the rate functions for inactivation and recovery from inactivation are consistent with the empirically determined expressions and exhibit saturation for both depolarized and hyperpolarized clamp potentials.

  15. Numerical simulations of piecewise deterministic Markov processes with an application to the stochastic Hodgkin-Huxley model

    Science.gov (United States)

    Ding, Shaojie; Qian, Min; Qian, Hong; Zhang, Xuejuan

    2016-12-01

    The stochastic Hodgkin-Huxley model is one of the best-known examples of piecewise deterministic Markov processes (PDMPs), in which the electrical potential across a cell membrane, V(t), is coupled with a mesoscopic Markov jump process representing the stochastic opening and closing of ion channels embedded in the membrane. The rates of the channel kinetics, in turn, are voltage-dependent. Due to this interdependence, an accurate and efficient sampling of the time evolution of the hybrid stochastic systems has been challenging. The current exact simulation methods require solving a voltage-dependent hitting time problem for multiple path-dependent intensity functions with random thresholds. This paper proposes a simulation algorithm that approximates an alternative representation of the exact solution by fitting the log-survival function of the inter-jump dwell time, H(t), with a piecewise linear one. The latter uses interpolation points that are chosen according to the time evolution of the H(t), as the numerical solution to the coupled ordinary differential equations of V(t) and H(t). This computational method can be applied to all PDMPs. Pathwise convergence of the approximated sample trajectories to the exact solution is proven, and error estimates are provided. Comparison with a previous algorithm that is based on piecewise constant approximation is also presented.

  16. Stochastic resonance, coherence resonance, and spike timing reliability of Hodgkin-Huxley neurons with ion-channel noise

    Science.gov (United States)

    Yu, Haitao; Galán, Roberto F.; Wang, Jiang; Cao, Yibin; Liu, Jing

    2017-04-01

    The random transitions of ion channels between open and closed states are a major source of noise in neurons. In this study, we investigate the stochastic dynamics of a single Hodgkin-Huxley (HH) neuron with realistic, physiological channel noise, which depends on the channel number and the voltage potential of the membrane. Without external input, the stochastic HH model can generate spontaneous spikes induced by ion-channel noise, and the variability of inter-spike intervals attains a minimum for an optimal membrane area, a phenomenon known as coherence resonance. When a subthreshold periodic input current is added, the neuron can optimally detect the input frequency for an intermediate membrane area, corresponding to the phenomenon of stochastic resonance. We also investigate spike timing reliability of neuronal responses to repeated presentations of the same stimulus with different realizations of channel noise. We show that, with increasing membrane area, the reliability of neuronal response decreases for subthreshold periodic inputs, and attains a minimum for suprathreshold inputs. Furthermore, Arnold tongues of high reliability arise in a two-dimensional plot of frequency and amplitude of the sinusoidal input current, resulting from the resonance effect of spike timing reliability.

  17. Optimal time scales of input fluctuations for spiking coherence and reliability in stochastic Hodgkin-Huxley neurons

    Science.gov (United States)

    Guo, Xinmeng; Wang, Jiang; Liu, Jing; Yu, Haitao; Galán, Roberto F.; Cao, Yibin; Deng, Bin

    2017-02-01

    Channel noise, which is generated by the random transitions of ion channels between open and closed states, is distinguished from external sources of physiological variability such as spontaneous synaptic release and stimulus fluctuations. This inherent stochasticity in ion-channel current can lead to variability of the timing of spikes occurring both spontaneously and in response to stimuli. In this paper, we investigate how intrinsic channel noise affects the response of stochastic Hodgkin-Huxley (HH) neuron to external fluctuating inputs with different amplitudes and correlation time. It is found that there is an optimal correlation time of input fluctuations for the maximal spiking coherence, where the input current has a fluctuating rate approximately matching the inherent oscillation of stochastic HH model and plays a dominating role in the timing of spike firing. We also show that the reliability of spike timing in the model is very sensitive to the properties of the current input. An optimal time scale of input fluctuations exists to induce the most reliable firing. The channel-noise-induced unreliability can be mostly overridden by injecting a fluctuating current with an appropriate correlation time. The spiking coherence and reliability can also be regulated by the size of channel stochasticity. As the membrane area (or total channel number) of the neuron increases, the spiking coherence decreases but the spiking reliability increases.

  18. Pregnancy as protest in interwar British women's writing: an antecedent alternative to Aldous Huxley's Brave New World.

    Science.gov (United States)

    Bigman, Fran

    2016-12-01

    Accounts that take Aldous Huxley's Brave New World (1932) as representative of interwar reproductive dystopia fail to recognise that the novel expresses both an interest and an anxiety about the possibility of new reproductive technologies to transform sex, gender, and the family that were widely shared by writers in different genres and perhaps expressed best by those likely to be most affected: women. This article explores three earlier works-Charlotte Haldane's Man's World (1926), Vera Brittain's Halcyon, or the Future of Monogamy (1929), and Naomi Mitchison's Comments on Birth Control (1930)-in which pregnancy, instead of figuring as illness or debility, becomes a form of resistance to the status quo. These works engage with biomedicine, however, rather than abjuring it. Through a reading of these works, this article argues that the intersection of medical humanities and science fiction (SF) can enrich both: medical humanities can push SF to go beyond the canon, and SF can challenge any characterisation of literature in the medical humanities as purely fantastical by demonstrating how it responds to the hopes and anxieties of a particular time. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  19. Effects of channel noise on synchronization transitions in delayed scale-free network of stochastic Hodgkin-Huxley neurons

    Institute of Scientific and Technical Information of China (English)

    王宝英; 龚玉兵

    2015-01-01

    We numerically study the effect of the channel noise on the spiking synchronization of a scale-free Hodgkin–Huxley neuron network with time delays. It is found that the time delay can induce synchronization transitions at an intermediate and proper channel noise intensity, and the synchronization transitions become strongest when the channel noise intensity is optimal. The neurons can also exhibit synchronization transitions as the channel noise intensity is varied, and this phenomenon is enhanced at around the time delays that can induce the synchronization transitions. It is also found that the synchronization transitions induced by the channel noise are dependent on the coupling strength and the network average degree, and there is an optimal coupling strength or network average degree with which the synchronization transitions become strongest. These results show that by inducing synchronization transitions, the channel noise has a big regulation effect on the synchronization of the neuronal network. These findings could find potential implications for the information transmission in neural systems.

  20. Effects of information transmission delay and channel blocking on synchronization in scale-free Hodgkin-Huxley neuronal networks

    Institute of Scientific and Technical Information of China (English)

    Qing-Yun Wang; Yan-Hong Zheng

    2011-01-01

    In this paper,we investigate the evolution of spatiotemporal patterns and synchronization transitions in dependence on the information transmission delay and ion channel blocking in scale-free neuronal networks.As the underlying model of neuronal dynamics,we use the HodgkinHuxley equations incorporating channel blocking and intrinsic noise.It is shown that delays play a significant yet subtle role in shaping the dynamics of neuronal networks.In particular,regions of irregular and regular propagating excitatory fronts related to the synchronization transitions appear intermittently as the delay increases.Moreover,the fraction of working sodium and potassium ion channels can also have a significant impact on the spatiotemporal dynamics of neuronal networks.As the fraction of blocked sodium channels increases,the frequency of excitatory events decreases,which in turn manifests as an increase in the neuronal synchrony that,however,is dysfunctional due to the virtual absence of large-amplitude excitations.Expectedly,we also show that larger coupling strengths improve synchronization irrespective of the information transmission delay and channel blocking.The presented results are also robust against the variation of the network size,thus providing insights that could facilitate understanding of the joint impact of ion channel blocking and information transmission delay on the spatiotemporal dynamics of neuronal networks.

  1. 一类Hodgkin-Huxley模型的分支研究%Bifurcation Analysis of a Hodgkin-Huxley-Type Model

    Institute of Scientific and Technical Information of China (English)

    李敏; 刘宣亮; 刘深泉

    2013-01-01

    This paper consider the Hodgkin-Huxley model in muscels, by using the bifurcation theory of differential equations and mumerical simulation, we discuss the one-parameter and two-parameter bifurcations of the model. The Bogdanov-Takens bifurcation are also discussed. We obtain the saddle-node bifurcation curve, the Hopf bifurcation curve and the Homoclinic bifurcation curve near the Bogdanov-Takens point.%考虑一类描述肌细胞膜电位变化的Hodgkin-Huxley模型的分支问题.利用常微分方程的分支理论,结合数值模拟结果,对模型的单参数分支与双参数分支进行了讨论.分析了Bogdanov-Takens分支,得到了相应的鞍结点分支曲线, Hopf分支曲线与同宿分支曲线.

  2. Effects of channel noise on synchronization transitions in delayed scale-free network of stochastic Hodgkin-Huxley neurons

    Science.gov (United States)

    Wang, Bao-Ying; Gong, Yu-Bing

    2015-11-01

    We numerically study the effect of the channel noise on the spiking synchronization of a scale-free Hodgkin-Huxley neuron network with time delays. It is found that the time delay can induce synchronization transitions at an intermediate and proper channel noise intensity, and the synchronization transitions become strongest when the channel noise intensity is optimal. The neurons can also exhibit synchronization transitions as the channel noise intensity is varied, and this phenomenon is enhanced at around the time delays that can induce the synchronization transitions. It is also found that the synchronization transitions induced by the channel noise are dependent on the coupling strength and the network average degree, and there is an optimal coupling strength or network average degree with which the synchronization transitions become strongest. These results show that by inducing synchronization transitions, the channel noise has a big regulation effect on the synchronization of the neuronal network. These findings could find potential implications for the information transmission in neural systems. Project supported by the Natural Science Foundation of Shandong Province of China (Grant No. ZR2012AM013).

  3. Optimal size of stochastic Hodgkin-Huxley neuronal systems for maximal energy efficiency in coding pulse signals

    Science.gov (United States)

    Yu, Lianchun; Liu, Liwei

    2014-03-01

    The generation and conduction of action potentials (APs) represents a fundamental means of communication in the nervous system and is a metabolically expensive process. In this paper, we investigate the energy efficiency of neural systems in transferring pulse signals with APs. By analytically solving a bistable neuron model that mimics the AP generation with a particle crossing the barrier of a double well, we find the optimal number of ion channels that maximizes the energy efficiency of a neuron. We also investigate the energy efficiency of a neuron population in which the input pulse signals are represented with synchronized spikes and read out with a downstream coincidence detector neuron. We find an optimal number of neurons in neuron population, as well as the number of ion channels in each neuron that maximizes the energy efficiency. The energy efficiency also depends on the characters of the input signals, e.g., the pulse strength and the interpulse intervals. These results are confirmed by computer simulation of the stochastic Hodgkin-Huxley model with a detailed description of the ion channel random gating. We argue that the tradeoff between signal transmission reliability and energy cost may influence the size of the neural systems when energy use is constrained.

  4. Derivation of Hodgkin-Huxley equations for a Na^{+} channel from a master equation for coupled activation and inactivation.

    Science.gov (United States)

    Vaccaro, S R

    2016-11-01

    The Na^{+} current in nerve and muscle membranes may be described in terms of the activation variable m(t) and the inactivation variable h(t), which are dependent on the transitions of S4 sensors of each of the Na^{+} channel domains DI to DIV. The time-dependence of the Na^{+} current and the rate equations satisfied by m(t) and h(t) may be derived from the solution to a master equation that describes the coupling between two or three activation sensors regulating the Na^{+} channel conductance and a two-stage inactivation process. If the inactivation rate from the closed or open states increases as the S4 sensors activate, a more general form of the Hodgkin-Huxley expression for the open-state probability may be derived where m(t) is dependent on both activation and inactivation processes. The voltage dependence of the rate functions for inactivation and recovery from inactivation are consistent with the empirically determined expressions and exhibit saturation for both depolarized and hyperpolarized clamp potentials.

  5. Numerical simulations of piecewise deterministic Markov processes with an application to the stochastic Hodgkin-Huxley model.

    Science.gov (United States)

    Ding, Shaojie; Qian, Min; Qian, Hong; Zhang, Xuejuan

    2016-12-28

    The stochastic Hodgkin-Huxley model is one of the best-known examples of piecewise deterministic Markov processes (PDMPs), in which the electrical potential across a cell membrane, V(t), is coupled with a mesoscopic Markov jump process representing the stochastic opening and closing of ion channels embedded in the membrane. The rates of the channel kinetics, in turn, are voltage-dependent. Due to this interdependence, an accurate and efficient sampling of the time evolution of the hybrid stochastic systems has been challenging. The current exact simulation methods require solving a voltage-dependent hitting time problem for multiple path-dependent intensity functions with random thresholds. This paper proposes a simulation algorithm that approximates an alternative representation of the exact solution by fitting the log-survival function of the inter-jump dwell time, H(t), with a piecewise linear one. The latter uses interpolation points that are chosen according to the time evolution of the H(t), as the numerical solution to the coupled ordinary differential equations of V(t) and H(t). This computational method can be applied to all PDMPs. Pathwise convergence of the approximated sample trajectories to the exact solution is proven, and error estimates are provided. Comparison with a previous algorithm that is based on piecewise constant approximation is also presented.

  6. Collective temporal coherence for subthreshold signal encoding on a stochastic small-world Hodgkin-Huxley neuronal network

    Energy Technology Data Exchange (ETDEWEB)

    Ozer, Mahmut [Zonguldak Karaelmas University, Engineering Faculty, Department of Electrical and Electronics Engineering, 67100 Zonguldak (Turkey); Laboratory of Neurophysics and Physiology, UMR 8119 CNRS, Universite Paris Descartes, 45 rue des Saint-Peres, 75006 Paris (France)], E-mail: mahmutozer2002@yahoo.com; Uzuntarla, Muhammet [Zonguldak Karaelmas University, Engineering Faculty, Department of Electrical and Electronics Engineering, 67100 Zonguldak (Turkey); Kayikcioglu, Temel [Karadeniz Technical University, Department of Electrical and Electronics Engineering, Trabzon (Turkey); Graham, Lyle J. [Laboratory of Neurophysics and Physiology, UMR 8119 CNRS, Universite Paris Descartes, 45 rue des Saint-Peres, 75006 Paris (France)

    2008-10-20

    We study the collective temporal coherence of a small-world network of coupled stochastic Hodgkin-Huxley neurons. Previous reports have shown that network coherence in response to a subthreshold periodic stimulus, thus subthreshold signal encoding, is maximal for a specific range of the fraction of randomly added shortcuts relative to all possible shortcuts, p, added to an initially locally connected network. We investigated this behavior further as a function of channel noise, stimulus frequency and coupling strength. We show that temporal coherence peaks when the frequency of the external stimulus matches that of the intrinsic subthreshold oscillations. We also find that large values of the channel noise, corresponding to small cell sizes, increases coherence for optimal values of the stimulus frequency and the topology parameter p. For smaller values of the channel noise, thus larger cell sizes, network coherence becomes insensitive to these parameters. Finally, the degree of coupling between neurons in the network modulates the sensitivity of coherence to topology, such that for stronger coupling the peak coherence is achieved with fewer added short cuts.

  7. "One of the Most Uniform Races of the Entire World": Creole Eugenics and the Myth of Chilean Racial Homogeneity.

    Science.gov (United States)

    Walsh, Sarah

    2015-11-01

    This article illuminates why Nicolás Palacios's 1904 monograph, Raza chilena: Libro escrito por un Chileno i para los Chilenos [Chilean Race: A Book Written by a Chilean for Chileans], is central to the creation of a myth of Chilean racial homogeneity at the turn of the twentieth century. Placing Palacios in the context of Latin American eugenic discourse, it demonstrates how he selected a specific racial origin story in order to accommodate his belief in racial hierarchy while also depicting race mixing in a positive light. Specifically, the article highlights how the myth of Chilean racial homogeneity elided the difference between the term "mestizo," which was applied to people of mixed racial heritage, and "white." I contend that Palacios sought to differentiate Chileans from other Latin Americans by emphasizing their racial distinctiveness. The article therefore highlights that Latin American eugenics was concerned with the creation of national narratives that historicized particular racial mixtures in order to reify and affirm national differences. As such, it connects to literature regarding the history of eugenics, race, nation, and the creation of whiteness.

  8. More than a Mentor: Leonard Darwin's Contribution to the Assimilation of Mendelism into Eugenics and Darwinism.

    Science.gov (United States)

    Serpente, Norberto

    2016-08-01

    This article discusses the contribution to evolutionary theory of Leonard Darwin (1850-1943), the eighth child of Charles Darwin. By analysing the correspondence Leonard Darwin maintained with Ronald Aylmer Fisher in conjunction with an assessment of his books and other written works between the 1910s and 1930s, this article argues for a more prominent role played by him than the previously recognised in the literature as an informal mentor of Fisher. The paper discusses Leonard's efforts to amalgamate Mendelism with both Eugenics and Darwinism in order for the first to base their policies on new scientific developments and to help the second in finding a target for natural selection. Without a formal qualification in biological sciences and as such mistrusted by some "formal" scientists, Leonard Darwin engaged with key themes of Darwinism such as mimicry, the role of mutations on speciation and the process of genetic variability, arriving at important conclusions concerning the usefulness of Mendelian genetics for his father's theory.

  9. [The development of criminal psychology in the work of Eugen Bleuler].

    Science.gov (United States)

    Möller, A; Hell, D

    1997-11-01

    The study refers to Eugen Bleuler's first systematic publications on "the natural born criminal" (1896) and his subsequent forensic-psychiatric expertise, written by Bleuler as Director of the psychiatric Department of Psychiatry of the University of Zurich ("Burghölzli"). It could be clearly shown that Bleuler was influenced by a deterministic understanding of human behaviour. He referred to the Anglo-American concept of "moral insanity" as a circumscribed defect of altruistic feelings despite other psychic functions being normal and tended to include this psychopathic deviation in psychiatry. Although this theoretic position remained unchanged, the elderly E. Beuler--under pragmatic points of view--accepted the traditional differentiation between mental illness in a narrower sense and "moral insanity" as a personality feature of most delinquents, falling under the responsibility of law and penal institutions. In his publications as emeritus (after 1927). Bleuler was influenced by the natural philosophic and vitalistic concept of the so-called "Minemism", which, however, still made him reject the postulate of "freedom of will".

  10. 尤金·奥尼尔(Eugene O'Neill)

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    尤金·奥尼尔(Eugene O’Neill,1888~1953年)美国著名剧作家,表现主义文学的代表作家,美国民族戏剧的奠基人。他4次获普利策奖,并于1936年获诺贝尔文学奖。他一生创作了45个剧本,题材广泛,风格多样。由于他的努力,美国的戏剧事业得以在20世纪20年代发展起来,成为美国文化领域中堪与小说、绘画、音乐作品相提并论的艺术形式。因而被公认为美国最重要的戏剧作家。

  11. 尤金·奥尼尔(Eugene O'Neill)

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    尤金·奥尼尔(Eugene O’Neill,1888~1953年)美国著名剧作家,表现主义文学的代表作家,美国民族戏剧的奠基人。他4次获普利策奖,并于1936年获诺贝尔文学奖。他一生创作了45个剧本,题材广泛,风格多样。由于他的努力,美国的戏剧事业得以在20世纪20年代发展起来,成为美国文化领域中堪与小说、绘画、音乐作品相提并论的艺术形式,因而被公认为美国最重要的戏剧作家。

  12. Eugenics, environment, and acclimatizing to Manchukuo: psychiatric studies of Japanese colonists.

    Science.gov (United States)

    Matsumura, Janice

    2010-09-01

    Both the advocates and critics of what has been called "the new imperial history," which may be characterized by its focus on how colonies were not simply influenced by but also exercised an influence on a dominating foreign state, have inspired this article. The article addresses the production and dissemination of medical knowledge in its examination of psychiatric research conducted in the 1930s in Japan's unofficial colony of Manchukuo. It highlights the political dimension of studies of psychosomatic disorders, syphilis, and alcoholism among colonists by placing it in the context of contending theories of racial improvement and growing official support for mass migration, especially to northeast China. Moreover, it inquires into restrictions on the flow of ideas from the colonies by examining how these studies were received in Japan. While interest in the colonies ensured that psychiatrists in Manchukuo were able to publish their research in leading Japanese medical journals, their findings jeopardized too many political and professional interests to become more public. In much-publicized debates stimulated by the impeding establishment of eugenic sterilization legislation, their colleagues in Japan in the late 1930s who championed the argument of environment over heredity were conspicuously silent about conditions among Japanese colonists, using instead examples of European and North American colonists to make their case.

  13. In Genes We Trust: Germline Engineering, Eugenics, and the Future of the Human Genome.

    Science.gov (United States)

    Powell, Russell

    2015-12-01

    Liberal proponents of genetic engineering maintain that developing human germline modification technologies is morally desirable because it will result in a net improvement in human health and well-being. Skeptics of germline modification, in contrast, fear evolutionary harms that could flow from intervening in the human germline, and worry that such programs, even if well intentioned, could lead to a recapitulation of the scientifically and morally discredited projects of the old eugenics. Some bioconservatives have appealed as well to the value of retaining our "given" human biological nature as a reason for restraining the development and use of human genetic modification technologies even where they would tend to increase well-being. In this article, I argue that germline intervention will be necessary merely to sustain the levels of genetic health that we presently enjoy for future generations-a goal that should appeal to bioliberals and bioconservatives alike. This is due to the population-genetic consequences of relaxed selection pressures in human populations caused by the increasing efficacy and availability of conventional medicine. This heterodox conclusion, which I present as a problem of intergenerational justice, has been overlooked in medicine and bioethics due to certain misconceptions about human evolution, which I attempt to rectify, as well as the sordid history of Darwinian approaches to medicine and social policy, which I distinguish from the present argument.

  14. The Genomic Revolution and Beliefs about Essential Racial Differences: A Backdoor to Eugenics?

    Science.gov (United States)

    Phelan, Jo C; Link, Bruce G; Feldman, Naumi M

    2013-04-01

    Could the explosion of genetic research in recent decades affect our conceptions of race? In Backdoor to Eugenics, Duster argues that reports of specific racial differences in genetic bases of disease, in part because they are presented as objective facts whose social implications are not readily apparent, may heighten public belief in more pervasive racial differences. We tested this hypothesis with a multi-method study. A content analysis showed that news articles discussing racial differences in genetic bases of disease increased significantly between 1985 and 2008 and were significantly less likely than non-health-related articles about race and genetics to discuss social implications. A survey experiment conducted with a nationally representative sample of 559 adults found that a news-story vignette reporting a specific racial difference in genetic risk for heart attacks (the Backdoor Vignette) produced significantly greater belief in essential racial differences than did a vignette portraying race as a social construction or a no-vignette condition. The Backdoor Vignette produced beliefs in essential racial differences that were virtually identical to those produced by a vignette portraying race as a genetic reality. These results suggest that an unintended consequence of the genomic revolution may be the reinvigoration of age-old beliefs in essential racial differences.

  15. Mean-field description and propagation of chaos in networks of Hodgkin-Huxley and FitzHugh-Nagumo neurons.

    Science.gov (United States)

    Baladron, Javier; Fasoli, Diego; Faugeras, Olivier; Touboul, Jonathan

    2012-05-31

    We derive the mean-field equations arising as the limit of a network of interacting spiking neurons, as the number of neurons goes to infinity. The neurons belong to a fixed number of populations and are represented either by the Hodgkin-Huxley model or by one of its simplified version, the FitzHugh-Nagumo model. The synapses between neurons are either electrical or chemical. The network is assumed to be fully connected. The maximum conductances vary randomly. Under the condition that all neurons' initial conditions are drawn independently from the same law that depends only on the population they belong to, we prove that a propagation of chaos phenomenon takes place, namely that in the mean-field limit, any finite number of neurons become independent and, within each population, have the same probability distribution. This probability distribution is a solution of a set of implicit equations, either nonlinear stochastic differential equations resembling the McKean-Vlasov equations or non-local partial differential equations resembling the McKean-Vlasov-Fokker-Planck equations. We prove the well-posedness of the McKean-Vlasov equations, i.e. the existence and uniqueness of a solution. We also show the results of some numerical experiments that indicate that the mean-field equations are a good representation of the mean activity of a finite size network, even for modest sizes. These experiments also indicate that the McKean-Vlasov-Fokker-Planck equations may be a good way to understand the mean-field dynamics through, e.g. a bifurcation analysis.Mathematics Subject Classification (2000): 60F99, 60B10, 92B20, 82C32, 82C80, 35Q80.

  16. Voltage dependence of Hodgkin-Huxley rate functions for a multistage K^{+} channel voltage sensor within a membrane.

    Science.gov (United States)

    Vaccaro, S R

    2014-11-01

    The activation of a K^{+} channel sensor in two sequential stages during a voltage clamp may be described as the translocation of a Brownian particle in an energy landscape with two large barriers between states. A solution of the Smoluchowski equation for a square-well approximation to the potential function of the S4 voltage sensor satisfies a master equation and has two frequencies that may be determined from the forward and backward rate functions. When the higher-frequency terms have small amplitude, the solution reduces to the relaxation of a rate equation, where the derived two-state rate functions are dependent on the relative magnitude of the forward rates (α and γ) and the backward rates (β and δ) for each stage. In particular, the voltage dependence of the Hodgkin-Huxley rate functions for a K^{+} channel may be derived by assuming that the rate functions of the first stage are large relative to those of the second stage-α≫γ and β≫δ. For a Shaker IR K^{+} channel, the first forward and backward transitions are rate limiting (αchannel and a noninactivating Na^{+} ion channel is determined by the master equation for K^{+} channel activation and the ionic current equation when the Na^{+} channel activation time is small, and if β≪δ and α≪γ, the system may exhibit a small amplitude oscillation between spikes, or mixed-mode oscillation, in which the slow closed state modulates the K^{+} ion channel conductance in the membrane.

  17. Voltage dependence of Hodgkin-Huxley rate functions for a multistage K+ channel voltage sensor within a membrane

    Science.gov (United States)

    Vaccaro, S. R.

    2014-11-01

    The activation of a K+channel sensor in two sequential stages during a voltage clamp may be described as the translocation of a Brownian particle in an energy landscape with two large barriers between states. A solution of the Smoluchowski equation for a square-well approximation to the potential function of the S4 voltage sensor satisfies a master equation and has two frequencies that may be determined from the forward and backward rate functions. When the higher-frequency terms have small amplitude, the solution reduces to the relaxation of a rate equation, where the derived two-state rate functions are dependent on the relative magnitude of the forward rates (α and γ ) and the backward rates (β and δ ) for each stage. In particular, the voltage dependence of the Hodgkin-Huxley rate functions for a K+channel may be derived by assuming that the rate functions of the first stage are large relative to those of the second stage—α ≫γ and β ≫δ . For a Shaker IR K+ channel, the first forward and backward transitions are rate limiting (α <γ and δ ≪β ), and for an activation process with either two or three stages, the derived two-state rate functions also have a voltage dependence that is of a similar form to that determined for the squid axon. The potential variation generated by the interaction between a two-stage K+ ion channel and a noninactivating Na+ ion channel is determined by the master equation for K+channel activation and the ionic current equation when the Na+channel activation time is small, and if β ≪δ and α ≪γ , the system may exhibit a small amplitude oscillation between spikes, or mixed-mode oscillation, in which the slow closed state modulates the K+ ion channel conductance in the membrane.

  18. The influence of ion concentrations on the dynamic behavior of the Hodgkin-Huxley model-based cortical network.

    Science.gov (United States)

    Tagluk, M Emin; Tekin, Ramazan

    2014-08-01

    Action potentials (APs) in the form of very short pulses arise when the cell is excited by any internal or external stimulus exceeding the critical threshold of the membrane. During AP generation, the membrane potential completes its natural cycle through typical phases that can be formatted by ion channels, gates and ion concentrations, as well as the synaptic excitation rate. On the basis of the Hodgkin-Huxley cell model, a cortical network consistent with the real anatomic structure is realized with randomly interrelated small population of neurons to simulate a cerebral cortex segment. Using this model, we investigated the effects of Na(+) and K(+) ion concentrations on the outcome of this network in terms of regularity, phase locking, and synchronization. The results suggested that Na(+) concentration does slightly affect the amplitude but not considerably affects the other parameters specified by depolarization and repolarization. K(+) concentration significantly influences the form, regularity, and synchrony of the network-generated APs. No previous study dealing directly with the effects of both Na(+) and K(+) ion concentrations on regularity and synchronization of the simulated cortical network-generated APs, allowing for the comparison of results obtained using our methods, was encountered in the literature. The results, however, were consistent with those obtained through studies concerning resonance and synchronization from another perspective and with the information revealed through physiological and pharmacological experiments concerning changing ion concentrations or blocking ion channels. Our results demonstrated that the regularity and reliability of brain functions have a strong relationship with cellular ion concentrations, and suggested the management of the dynamic behavior of the cellular network with ion concentrations.

  19. A library of analog operators based on the hodgkin-huxley formalism for the design of tunable, real-time, silicon neurons.

    Science.gov (United States)

    Saïghi, S; Bornat, Y; Tomas, J; Le Masson, G; Renaud, S

    2011-02-01

    In this paper, we present a library of analog operators used for the analog real-time computation of the Hodgkin-Huxley formalism. These operators make it possible to design a silicon (Si) neuron that is dynamically tunable, and that reproduces different kinds of neurons. We used an original method in neuromorphic engineering to characterize this Si neuron. In electrophysiology, this method is well known as the "voltage-clamp" technique. We also compare the features of an application-specific integrated circuit built with this library with results obtained from software simulations. We then present the complex behavior of neural membrane voltages and the potential applications of this Si neuron.

  20. Solitary wave and periodic wave solutions for Burgers, Fisher, Huxley and combined forms of these equations by the (′/)-expansion method

    Indian Academy of Sciences (India)

    Jalil Manafian; Mehrdad Lakestani

    2015-07-01

    An application of the (′/)-expansion method to search for exact solutions of nonlinear partial differential equations is analysed. This method is used for Burgers, Fisher, Huxley equations and combined forms of these equations. The (′/)-expansion method was used to construct periodic wave and solitary wave solutions of nonlinear evolution equations. This method is developed for searching exact travelling wave solutions of nonlinear partial differential equations. It is shown that the (′/)-expansion method, with the help of symbolic computation, provides a straightforward and powerful mathematical tool for solving nonlinear partial differential equations.

  1. A Phase-Locking Analysis of Neuronal Firing Rhythms with Transcranial Magneto-Acoustical Stimulation Based on the Hodgkin-Huxley Neuron Model.

    Science.gov (United States)

    Yuan, Yi; Pang, Na; Chen, Yudong; Wang, Yi; Li, Xiaoli

    2017-01-01

    Transcranial magneto-acoustical stimulation (TMAS) uses ultrasonic waves and a static magnetic field to generate electric current in nerve tissues for the purpose of modulating neuronal activities. It has the advantage of high spatial resolution and penetration depth. Neuronal firing rhythms carry and transmit nerve information in neural systems. In this study, we investigated the phase-locking characteristics of neuronal firing rhythms with TMAS based on the Hodgkin-Huxley neuron model. The simulation results indicate that the modulation frequency of ultrasound can affect the phase-locking behaviors. The results of this study may help us to explain the potential firing mechanism of TMAS.

  2. Entre a civilização e a selvajaria : os estereótipos do nativo americano e o selvagem de Brave New World de Aldous Huxley

    OpenAIRE

    Rebelo, Maria Raquel de Gouveia Durão Pina

    1999-01-01

    A presente dissertação apresenta, num primeiro momento, um estudo dos estereótipos do Ameríndio - nomeadamente o Bom-Selvagem e o canibal feroz e amoral -, formados pela mente branca europeia e americana numa atitude de contraponto entre culturas. Este estudo, baseado em textos representativos de várias épocas, serve de base à deconstrucção satírica que aldous Huxley faz desses estereótipos e à subversão das categorias discursivas oposicionais nas quais eles assentam e que levaram à distinção...

  3. An Evil Hitherto Unchecked: Eugenics and the 1917 Ontario Royal Commission on the Care and Control of the Mentally Defective and Feeble-Minded.

    Science.gov (United States)

    Koester, C Elizabeth

    2016-01-01

    In 1917, the Ontario government appointed the Royal Commission on the Care and Control of the Mentally Defective and Feeble-Minded, headed by Justice Frank Hodgins. Its final report made wide-ranging recommendations regarding the segregation of feeble-minded individuals, restrictions on marriage, the improvement of psychiatric facilities, and the reform of the court system, all matters of great concern to the eugenics movement. At the same time, however, it refrained from using explicitly eugenic vocabulary and ignored the question of sterilization. This article explores the role the commission played in the trajectory of eugenics in Ontario (including the province's failure to pass sterilization legislation) and considers why its recommendations were disregarded.

  4. Leaders in Cardiovascular Medicine. Eugene Braunwald MD: an icon of the 20th century still going strong.

    Science.gov (United States)

    Braunwald, Eugene; Nicholls, Mark

    2015-06-07

    Considered one of the pre-eminent cardiologists of our time, Dr Eugene Braunwald, MD, has extended knowledge of congestive heart failure, coronary artery disease, and valvular heart disease. Having published hundreds of papers and medical articles, with his textbook Braunwald’s Heart Disease cited worldwide, Dr Braunwald has received numerous honours and awards. Born in Austria in 1929, his family emigrated to the USA during World War II and after his studies he began a long, successful and hugely-influential career as a cardiologist. Now well into his 80s, he still practices medicine and continues to contribute to the field of cardiology.

  5. 广义Burgers—Huxley方程解的数值模拟%The numerical simulation of the solutions for the generalized Burgers-Huxley equation

    Institute of Scientific and Technical Information of China (English)

    刘玉华; 张金良; 李留涛

    2012-01-01

    广义Burgers—Huxley方程是一个非常重要的模型,在流体力学、化学反应、生物工程、自动控制等领域有着广泛的应用.借助于有限差分、对角隐式Runge—Kutta-NystrSm(DIRKN),对广义Burgers·Huxley方程的精确解进行了数值模拟,由模拟的图形及误差可以看出本文的方法是有效的,但是若方程的非线性较强时,数值结果的误差相对较大.%The generalized Burgers-Huxley equation is an important model, it has wide applications in fluid mechanics, chemical reaction, bioengineering, automatic control, etc. In this paper, the exact solutions of the generalized Burgers-Huxley equation are numerically simulated using the finite difference method and diagonal implicit Runge-Kutta-Nystrom method. From the simulation figures and errors, the method used in this paper is efficient, if the nonlinearity is strong, the error becomes bigger.

  6. Nasty Nazis and Extreme Americans: Cloning, Eugenics, and the Exchange of National Signifiers in Contemporary Science Fiction

    Directory of Open Access Journals (Sweden)

    Elizabeth Bridges

    2014-01-01

    Full Text Available This article addresses German science fiction novels from the last ten to fifteen years, specifically those that thematize cloning and/or eugenics. The main novels under discussion include Die verbesserte Frau by Barbara Kirchner , Duplik Jonas 7 by Birgit Rabisch, and Blueprint/Blaupause by Charlotte Kerner, (which was released as a film adaptation starring Franka Potente in 2004. This discussion shows how these and similar novels do or do not contend with the legacy of Nazi eugenics and reproductive experimentation, and second, how the existent historical awareness in the novels relates to the content of debates on current issues of biotechnology, including those by Jürgen Habermas, Slavoj Zizek, and Peter Sloterdijk. The article concludes by bringing these debates to bear on cultural cross-referencing in comparative examples of American texts ( Gattaca [1997] , The Island [2005] , to name two, which tend to imbue frightening aspects of reproductive technologies with signifiers of Nazism, while the German texts tend to implicate America as the future source of nightmarish reproductive possibilities.

  7. Avoiding genetic genocide: understanding good intentions and eugenics in the complex dialogue between the medical and disability communities.

    Science.gov (United States)

    Miller, Paul Steven; Levine, Rebecca Leah

    2013-02-01

    The relationship between the medical and disability communities is complex and is influenced by historical, social, and cultural factors. Although clinicians, health-care researchers, and people with disabilities all work from the standpoint of the best interest of disabled individuals, the notion of what actually is "best" is often understood quite differently among these constituencies. Eugenics campaigns, legal restrictions on reproductive and other freedoms, and prenatal testing recommendations predicated on the lesser worth of persons with disabilities have all contributed toward the historic trauma experienced by the disability community, particularly with respect to medical genetics. One premise of personalized medicine is that different individuals require different solutions. Disabled persons' experiences are a reminder that these solutions can be best realized by maintaining awareness and sensitivity in a complex ethical and moral terrain. Geneticists should recognize that their research may have implications for those with disabilities; they should recognize the impact of the historical trauma of the eugenics movement, and seek to involve people with disabilities in discussions about policies that affect them. Dialogue can be messy and uncomfortable, but it is the only way to avoid the mistakes of the past and to ensure a more equitable, and healthful, future.

  8. Professor Eugen Cerkovnikov (1904-1985): the founder of the Chemical and Biochemical Institute of the Rijeka University School of Medicine.

    Science.gov (United States)

    Milin, Cedomila

    2008-01-01

    Professor Eugen Cerkovnikov, PhD (Kamenska, Russia, 1904- Rijeka, Croatia 1985) graduated in chemical technology from the Faculty of Engineering in Zagreb in 1929. His first job was at the School of Medicine in Paris in 1930, and then he moved to Zagreb to the Department of Organic Chemistry of the Faculty of Engineering run by our Nobel Prize winner Vladimir Prelog (1935-1938). There he took his PhD degree with a dissertation on piperidine gamma derivatives. From 1938 to 1947 he was a research associate at an institute established by the pharmaceutical company Kastel (later Pliva). This is when he became a lecturer at the Faculty of Pharmacy in Zagreb and the first director of the Institute of Organic Chemistry, established in 1946/47. In 1948 he became reader, and in 1956 (full) professor. In 1957 he moved to the newly established School of Medicine in Rijeka, and set up the Institute of Chemistry and Biochemistry. He ran the Institute until retirement in 1975. He was the second dean of the Rijeka University School of Medicine and a pioneer of quantum chemistry and medical cybernetics in undergraduate and (post)graduate courses. His scientific work consists of over 200 papers published at home and abroad, 60 professional papers, 20 book reviews, three works of translation, and 27 volumes of lecture notes. In 1958, professor Cerkovnikov established the Croatian Chemical Society and the Rijeka and Istria branches of the nation's Association of Chemists and Chemical Engineers, chairing them until 1974. In addition, he was one of the founding fathers, and the first chair of the Health Culture Studies Association in Rijeka (that preceded today's Croatian Scientific Society for the History of Health Culture), established in 1965.

  9. [Baltic eugenics: Bio-politics, race and nation in interwar Estonia, Latvia and Lithuania 1918-1940] / Raiko Jäärats

    Index Scriptorium Estoniae

    Jäärats, Raiko, 1980-

    2014-01-01

    Arvustus: Baltic eugenics: Bio-politics, race and nation in interwar Estonia, Latvia and Lithuania 1918-1940 (On the boundary of two worlds. identity, fredom and moral imagination in the Baltics, 35). Hrsg. von Björn M. Felder und Paul J. Weindling. Rodopi, Amsterdam u.a. 2013

  10. A Hidden History: A Survey of the Teaching of Eugenics in Health, Social Care and Pedagogical Education and Training Courses in Europe

    Science.gov (United States)

    Atherton, H. L.; Steels, S. L.

    2016-01-01

    Knowledge and understanding of how eugenics has historically affected the lives of people with intellectual disabilities is vital if professionals are to mount an effective defence against its contemporary influences. An online survey of European providers of health, social care and pedagogical education and training courses was undertaken to find…

  11. [Baltic eugenics: Bio-politics, race and nation in interwar Estonia, Latvia and Lithuania 1918-1940] / Raiko Jäärats

    Index Scriptorium Estoniae

    Jäärats, Raiko, 1980-

    2014-01-01

    Arvustus: Baltic eugenics: Bio-politics, race and nation in interwar Estonia, Latvia and Lithuania 1918-1940 (On the boundary of two worlds. identity, fredom and moral imagination in the Baltics, 35). Hrsg. von Björn M. Felder und Paul J. Weindling. Rodopi, Amsterdam u.a. 2013

  12. TORCH抗体检测及其对优生优育的意义%TORCH antibody detection and its significance in eugenics

    Institute of Scientific and Technical Information of China (English)

    陈延斌; 吕祺

    2011-01-01

    Objective: Compare serum TORCH infections of eugenic checking women and infertilities. Methods: Using ELISA detect serum antibody of Toxopolasma, Rubellavirus, Cytomegalovirus, Herpes simplex virus type Ⅰ and type Ⅱ in 158 eugenic checking women and 213 infertilities. Results: The positive rate of IgM antibody of Toxopolasma, Rubellavirus, Cytomegalovirus, Herpes simplex virus in eugenic checking women was 1.9%, 3.2%, 1.9%, 7. 5% and that of infertilities was 2. 3%, 5.2%, 5.2%,8. 5%. Conclusions: There was no significant difference ( P <0. 05) between eugenic checking women and infertilities except CMV - IgM. It is very important for eugenics to test TORCH - IgM.%目的 比较优生优育检查和不孕不育妇女的血清TORCH感染情况.方法 对158例进行优生优育检查妇女和213例不孕不育妇女采用ELISA法检测血清中特异性TORCH系列IgM抗体.结果 优生优育组弓形虫(TOX)、风疹病毒(RUV)、巨细胞病毒(CMV)、单纯疙疹病毒(HSV)IgM抗体阳性率分别为1.9%,3.2%,1.9%,7.5%.不孕不育组的抗体阳性率分别为2.3%,5.2%,5.2%,8.5%.结论 优生优育组与不孕不育组妇女间仅有CMV-IgM感染率有显著性差异(P<0.05).TORCH检查对优生优育有重要的意义.

  13. Stochastic sensitivity analysis of noise-induced suppression of firing and giant variability of spiking in a Hodgkin-Huxley neuron model

    Science.gov (United States)

    Bashkirtseva, Irina; Neiman, Alexander B.; Ryashko, Lev

    2015-05-01

    We study the stochastic dynamics of a Hodgkin-Huxley neuron model in a regime of coexistent stable equilibrium and a limit cycle. In this regime, noise may suppress periodic firing by switching the neuron randomly to a quiescent state. We show that at a critical value of the injected current, the mean firing rate depends weakly on noise intensity, while the neuron exhibits giant variability of the interspike intervals and spike count. To reveal the dynamical origin of this noise-induced effect, we develop the stochastic sensitivity analysis and use the Mahalanobis metric for this four-dimensional stochastic dynamical system. We show that the critical point of giant variability corresponds to the matching of the Mahalanobis distances from attractors (stable equilibrium and limit cycle) to a three-dimensional surface separating their basins of attraction.

  14. Stochastic sensitivity analysis of noise-induced suppression of firing and giant variability of spiking in a Hodgkin-Huxley neuron model.

    Science.gov (United States)

    Bashkirtseva, Irina; Neiman, Alexander B; Ryashko, Lev

    2015-05-01

    We study the stochastic dynamics of a Hodgkin-Huxley neuron model in a regime of coexistent stable equilibrium and a limit cycle. In this regime, noise may suppress periodic firing by switching the neuron randomly to a quiescent state. We show that at a critical value of the injected current, the mean firing rate depends weakly on noise intensity, while the neuron exhibits giant variability of the interspike intervals and spike count. To reveal the dynamical origin of this noise-induced effect, we develop the stochastic sensitivity analysis and use the Mahalanobis metric for this four-dimensional stochastic dynamical system. We show that the critical point of giant variability corresponds to the matching of the Mahalanobis distances from attractors (stable equilibrium and limit cycle) to a three-dimensional surface separating their basins of attraction.

  15. [As the twig is bent, so is the tree inclined: children and the Liga Brasileira de Higiene Mental's eugenic programs].

    Science.gov (United States)

    Reis, J R

    2000-01-01

    Created in the early 1920s, at a moment when the country's psychiatric field was embracing the preventive outlook, the Liga Brasileira de Higiene Mental included within its members the elite of Brazilian psychiatry, along with a number of physicians and intellectuals. The article discusses the institution's proposals for intervention among children. The league ended up incorporating into its theoretical arsenal the basic themes of mental hygiene and eugenics as part of its general goal of collaborating in Brazil's process of "racial sanitation". With this objective in mind, and viewing the child as a "pre-citizen" who is a "fundamental part within the man of the future", league members included the children's issue in their projects and saw an imperative need for mental health care from early ages on.

  16. Supplement Analysis for the Transmission System Vegetation Management Program FEIS (DOE/EIS-0285/SA-127- Eugene-Alvey#2

    Energy Technology Data Exchange (ETDEWEB)

    Sherer, Brett M. [Bonneville Power Administration (BPA), Portland, OR (United States)

    2003-02-19

    BPA proposes to remove unwanted vegetation along the right-of-way, access roads, and around tower structures of the subject transmission line corridor that may impede the operation and maintenance of the identified transmission lines. BPA plans to conduct vegetation control with the goal of removing tall growing vegetation that is currently or will soon be a hazard to the transmission line. BPA’s overall goal is to have low-growing plant communities along the rights-of-way to control the development of potentially threatening vegetation. Vegetation Management for the Eugene-Alvey 115 kV transmission line from structure 7/1 through structure 12/2m, and along portions of the following adjacent transmission lines: Hawkins-Alvey 115KV and Alvey-Lane 115KV.

  17. MeSH--a unique partnership. An interview with Eugene E. Loubier, President, Franklin Medical Center, Greenfield, Massachusetts.

    Science.gov (United States)

    Loubier, E E

    1984-10-01

    HCSM's interview this month is with Eugene E. Loubier, FACHA, President of Franklin Medical Center, Greenfield, Massachusetts. This 162-bed facility is the first to start formally a MeSH plan, a unique medical staff/hospital joint venture or partnership. Through MeSH, the hospital and its medical staff have created a new corporation, equally owned by the hospital and the medical staff members participating in the MeSH. This corporation is responsible for areas where the economic interests of the physicians and the hospitals overlap. Instead of each party independently pursuing economic opportunities that might impact the other party, the MeSH can, as a whole, undertake the venture.

  18. Energy Edge Post-Occupancy Evaluation Project: The Emerald People's Utility District Building (EPUD) Eugene, Oregon

    Energy Technology Data Exchange (ETDEWEB)

    1990-06-01

    The Workspace Satisfaction Survey measures occupant satisfaction with the thermal, lighting, acoustical, and air quality aspects of the work environment. In addition to ratings of these ambient environmental features, occupants also rate their satisfaction with a number of functional and aesthetic features of the office environment as well as their satisfaction with specific kinds of workspaces (e.g., computer rooms, the lobby, employee lounge, etc.). Each section on ambient conditions includes questions on the frequency with which people experience particular kinds of discomforts or problems, how much the discomfort bothers them, and how much it interferes with their work. Occupants are also asked to identify how they cope with discomfort or environmental problems, and to what extent these behaviors enable them to achieve more satisfactory conditions. This report documents the results of this survey of the occupants of the Emerald People's Utility District office building in Eugene, Oregon.

  19. Pregnancy Eugenic TSH Result in Xiamen Area%厦门地区孕前优生TSH结果分析

    Institute of Scientific and Technical Information of China (English)

    田萍萍

    2015-01-01

    目的:对厦门地区孕前优生TSH结果进行分析。方法采用固相化学发光酶免疫分析测定2013年10月~2014年9月3464例进行孕前免费优生检查的育龄妇女血清TSH水平。结果3464例妇女中TSH异常95例,其中低于正常范围的45例占1.30%,高于参考范围的53例占1.53%,大于40岁及肥胖TSH升高比例较大。结论应重视育龄妇女孕前甲状腺功能筛查,特别是高龄及超重妇女,发现异常及时纠正再妊娠,减少妊娠不良预后,孕育健康子代。%Objective To analyze the pregnancy eugenic TSH in Xiamen. Methods From October 2013 to September 2014,we investigated the TSH levels of 3 464 pregnancy eugenic women of childbearing age using a solid phase chemiluminescent enzyme immunoassay assayserum.ResultsTSH abnormalities 95 cases in 3 464 cases of women,45 cases accounted for 1.30%,above the reference range of 53 cases accounted for 1.53%below the normal range, more than 40 years and a large proportion of obesity increased TSH.Conclusion We should pay attention to women of childbearing age before pregnancy thyroid function screening,especialy the elderly and overweight women,abnormal pregnancy and then promptly corrected,reduce adverse pregnancy outcomes,nurture a healthy offspring.

  20. Fotoperiodismo y etnografía: el caso de W. Eugene Smith y su proyecto sobre Deleitosa

    Directory of Open Access Journals (Sweden)

    Brandes, Stanley

    1998-12-01

    Full Text Available By relying on fieldwork as well as on library research, the author discusses a photographic event in the modern history of Spain that is little known by Spanish scholars: the expedition in June, 1950 of the great American photographer W. Eugene Smith and his two assistants to the village of Deleitosa, in the province of Cáceres. The author describes the methodology of Smith and his team, then analyzes the results of his work, the famous photographic documentary «A Spanish Village», published in LIFE magazine in 1951. He also assesses the social impact of this work in and out of Spain and compares the ethnographic photograph with that used in journalism.Este artículo, basado tanto en trabajo de campo como en investigación documental, trata de un episodio fotográfico en la historia española todavía poco reconocido por investigadores españoles: la expedición en junio del 1950 del gran fotógrafo estadounidense W. Eugene Smith y sus dos ayudantes al pueblo cacereño de Deleitosa. El artículo describe los métodos de trabajo de Smith y su equipo; analiza el resultado de este trabajo, es decir, el famoso ensayo fotográfico «Spanish Village», publicado en la revista Life en 1951; mide el impacto social de Smith dentro y fuera de España; y compara la fotografía etnográfica con la periodística.

  1. On non-linear dynamics and an optimal control synthesis of the action potential of membranes (ideal and non-ideal cases) of the Hodgkin-Huxley (HH) mathematical model

    Energy Technology Data Exchange (ETDEWEB)

    Chavarette, Fabio Roberto [Department of Mechanical Design, State University of Campinas, 13083-970 Campinas, SP (Brazil); State University of Sao Paulo at Rio Claro, C.P. 178, 13500-230 Rio Claro, SP (Brazil); Balthazar, Jose Manoel [Department of Mechanical Design, State University of Campinas, 13083-970 Campinas, SP (Brazil); State University of Sao Paulo at Rio Claro, C.P. 178, 13500-230 Rio Claro, SP (Brazil)], E-mail: jmbaltha@rc.unesp.br; Rafikov, Marat [Universidade Regional do Noroeste do Estado do Rio Grande do Sul 98700-000, C.P. 560, Ijui, RS (Brazil); Hermini, Helder Anibal [Department of Mechanical Design, State University of Campinas, 13083-970 Campinas, SP (Brazil)

    2009-02-28

    In this paper, we have studied the plasmatic membrane behavior using an electric circuit developed by Hodgkin and Huxley in 1952 and have dealt with the variation of the amount of time related to the potassium and sodium conductances in the squid axon. They developed differential equations for the propagation of electric signals; the dynamics of the Hodgkin-Huxley model have been extensively studied both from the view point of its their biological implications and as a test bed for numerical methods, which can be applied to more complex models. Recently, an irregular chaotic movement of the action potential of the membrane was observed for a number of techniques of control with the objective to stabilize the variation of this potential. This paper analyzes the non-linear dynamics of the Hodgkin-Huxley mathematical model, and we present some modifications in the governing equations of the system in order to make it a non-ideal one (taking into account that the energy source has a limited power supply). We also developed an optimal linear control design for the action potential of membranes. Here, we discuss the conditions that allow the use of control linear feedback for this kind of non-linear system.

  2. Género, cuerpo, gimnasia y sexualidad en los manuales educacionales higienistas y eugenésicos en Chile, 1870-1938

    Directory of Open Access Journals (Sweden)

    Manuel Durán Sandoval

    2015-03-01

    Full Text Available Este artículo aborda la conformación de un discurso eugenésico positivo heredero de las teorías higienistas ambientalistas y raciales de finales del siglo XIX. Esta tendencia se consolidó entre 1925 a 1938 con la conformación de una estructura institucional y programas de corte social con fuertes matices eugenésicos positivos, considerando el cuerpo y el “carácter” de la juventud como amalgama de la nación.En este contexto se desarrollaron desde fines del siglo XIX tentativas por constituir una medicina pública que propulsara un programa de educación y preservación de la juventud. Estas iniciativas de corte ambientalista pretendían potenciar las aptitudes física y morales de los jóvenes mediante planes de alimentación, higiene y gimnasia

  3. Reviews

    Science.gov (United States)

    2004-03-01

    WEB WATCH (204) Try unearthing some interesting information about archaeology BOOK REVIEWS (206) Teaching and assessing practical skills Book Review: Learn to drive with Sir Isaac Newton DVD REVIEW (207) Bring some sunshine into the classroom EQUIPMENT REVIEWS (208) Robust air puck takes a kicking Flowlog offers sensing options plus multimode datalogging Mastering Chladni figures takes practice but it offers surprises

  4. Some remarks on Eugen Fink’s Interpretation of phenomenology of Spiritand Hegel’s influence on the philosophy of the world

    OpenAIRE

    BERTOLINI SIMONA

    2015-01-01

    Phenomenology of Spirit and Hegel’s conception of the absolute had a decisive role in the genesis and development of Eugen Fink’s philosophy. While Husserl and Heidegger showed Fink two different and fruitful ways to interpret phenomenology, Hegel suggested and offered him the conceptual means with which to combine these theoretical models and elaborate a third phenomenological paradigm, based on the concept of world. This is not only valid for Fink’s early interpretation of Husserl’s thought...

  5. Siberis ellujäämisest saab ETV ekraanil dramaatiline telesari / Kärt Anvelt ; kommenteerinud Eugen Tamberg ja Urmas Voolpriit

    Index Scriptorium Estoniae

    Anvelt, Kärt, 1973-

    2010-01-01

    2012. aastal jõuab ekraanile 12-osaline ajalooline telesari tööpealkirjaga "Siber", mis tähistab 70 aasta möödumist eestlaste esimesest küüditamisest 14. juunil 1941. Sarja lavastaja Merle Karusoo, stsenaristid Merle Karusoo ja Katrin Saukas. Võtterühma peagi algavast sõidust Siberisse Tomski oblastisse, reisist valmib dokumentaalfilm. Kommenteerivad kunstnik Eugen Tamberg ja helirežissöör Urmas Voolpriit

  6. Eugene A. Nida, pionero de la traductología contemporánea: [Reseña de la monografía

    OpenAIRE

    Campos Plaza, Nicolás

    2009-01-01

    Esta obra colectiva que aquí presentamos es una monografía colectiva previa a la celebración del V Congreso Internacional Traducción, Texto e Interferencias, celebrado en la Universidad de Córdoba en diciembre de 2006 como homenaje a Eugene A. Nida. G.I. HUM 767 (ayudas a Grupos de Investigación de la Junta de Andalucía) / Editorial Comares (colección interlingua)

  7. 近代中国优生理论与实践探析%Research on the Theory and Practice of Eugenics in Modern China

    Institute of Scientific and Technical Information of China (English)

    王广义

    2011-01-01

    Modern China .West Learning Spreading to the East, Eugenics came to China. Some Books were wrote and legislation were formulated about the Eugenics and Rear Better Children by the government to people, Different views and methods were proposed, It is still historical references for the today. It suggest some Chinese people began to turn from quantity to quality in the choice of fertility behavior, and from the eugenic improve of individual of the family to the overall quality of the nation behavior.%近代中国,西学东渐,优生学传入中国.从政府到国人,著书立说,制定法规,对优生优育提出了不同的观点和方法,对今天的优生优育仍有历史借鉴的作用.这些表明,一些中国人在生育行为选择上开始了由量向质的过渡,也使个人家庭的优生行为开始变成民族素质的整体提高的行为.

  8. Luis Huerta: eugenesia, medicina y pedagogía en España Luis Huerta: Eugenics, Medicine and Pedagogy in Spain

    Directory of Open Access Journals (Sweden)

    Luis Miguel LÁZARO LORENTE

    2013-07-01

    Full Text Available En contraste con lo observable en la historiografía de otros países europeos y anglosajones, el estudio de la introducción y difusión de los principios y prácticas de la Eugenesia, como tema de investigación, no ha contado en España con muchos cultivadores. Menos todavía han sido objeto de estudio las relaciones del pensamiento eugénico con el ámbito pedagógico para indagar la recepción que tiene entre el Magisterio, y conocer el conjunto de reacciones que provoca, así como la participación de los maestros en la potencial difusión de sus planteamientos. Se aborda aquí una aproximación a ese tema centrando el análisis en las relaciones que en la España del primer tercio del siglo XX se establecen entre Medicina, Pedagogía y Eugenesia. Para ello tomamos como referente e hilo conductor la figura y el pensamiento del maestro asturiano Luis Huerta Naves, decidido impulsor y propagandista incansable de la Eugenesia en nuestro país.By comparison with the historiography of other European and Anglo-Saxon countries, the study of the origins and spread of Eugenics in Spain has not received much attention. Even less research has been done on the degree of acceptance of eugenic thought in the pedagogical domain or on the role teachers may have in the diffusion of eugenics. This paper attempts to explore the subject while focusing the analysis on the relations that were established among Medicine, Pedagogy and Eugenics in Spain during the first third of the 20th century. We will take as a point of reference and guiding line of thought the figure of the Asturian teacher Luis Huerta Naves, who was the driving force and tireless advocate of the eugenics movement in our country.

  9. Effect of Spike-Timing-Dependent Plasticity on Intrinsic Coherence Resonance in Newman-Watts Stochastic Hodgkin-Huxley Neuronal Networks

    Science.gov (United States)

    Xie, Huijuan; Gong, Yubing; Wang, Qi

    2016-07-01

    In this paper, we numerically study the effect of spike-timing-dependent plasticity (STDP) on coherence resonance (CR) induced by channel noise in adaptive Newman-Watts stochastic Hodgkin-Huxley neuron networks. It is found that STDP can either enhance or suppress the intrinsic CR when the adjusting rate of STDP decreases or increases. STDP can alter the effects of network randomness and network size on the intrinsic CR. Under STDP, for electrical coupling there are optimal network randomness and network size by which the intrinsic CR becomes strongest, however, for chemical coupling the intrinsic CR is always enhanced as network randomness or network size increases, which are different from the results for fixed coupling. These results show that the intrinsic CR of the neuronal networks can be either enhanced or suppressed by STDP, and there are optimal network randomness and network size by which the intrinsic CR becomes strongest. These findings could provide a new insight into the role of STDP for the information processing and transmission in neural systems.

  10. 基于HH模型的心肌细胞电模型%Electric Model of the Myocardial Cell Based on Hodgkin-Huxley Model

    Institute of Scientific and Technical Information of China (English)

    张莹; 李智

    2012-01-01

    A modeling and simulation methods of electrophysiological model of myocardial cells were proposed. Based on the Hodg- kin-Huxley model, equivalent circuit model of the rat's single cardiac muscle cell was built. Using fourth-order Rouge-Kutta algorithm, internal and external cardiac membrane ionic current and potential difference changes has been researched and analyzed. Making use of C Language, the program of the cardiac cell membrane was realized like equivalent circuit model, and the computer's simulation through Mat-lab software platform was realized. As a result, it obtained the result of simulation experience of electrophysiological model of cardiac muscle cell under every different kinds of stimulation.%提出了一种心肌细胞电生理模型的建模仿真方法.通过借助Hodgkin-Huxley模型对单个心肌细胞建立细胞膜的等效电路模型,利用四阶Rouge-Kutta算法,研究并分析了心肌细胞膜内外离子电流及电位差变化.然后用C语言完成了对细胞膜等效电路模型的编程,利用Matlab软件平台进行了计算机仿真,得到了心肌细胞电生理学模型在不同刺激下的仿真实验结果.

  11. Iterative learning control of synchronization of Hodgkin-Huxley neurons%Hodgkin-Huxley神经元同步的迭代学习控制

    Institute of Scientific and Technical Information of China (English)

    邓斌; 王晓军; 王江; 李会艳

    2014-01-01

    由于神经元模型和参数具有不确定性,加大了许多控制算法的应用难度,而迭代学习控制不需要精确的数学模型,因此适合神经元网络同步的控制.针对Hodgkin-Huxley(HH)神经元的同步控制问题,提出了基于PI型迭代学习控制算法.对四种不同情况下主从神经元同步控制进行仿真,结果表明,施加控制后从神经元能够迅速跟踪主神经元的动力学行为.研究结果证实了该控制算法的可行性和有效性.

  12. Enhancement of temporal coherence via time-periodic coupling strength in a scale-free network of stochastic Hodgkin-Huxley neurons

    Science.gov (United States)

    Yilmaz, Ergin; Baysal, Veli; Ozer, Mahmut

    2015-08-01

    We investigate the effects of time-periodic coupling strength on the temporal coherence or firing regularity of a scale-free network consisting of stochastic Hodgkin-Huxley (H-H) neurons. The temporal coherence exhibits a resonance-like behavior depending on the cell size or the channel noise intensity. The best temporal coherence requires an optimal channel noise intensity, and this coherence can be significantly increased by time-periodic coupling strength when its frequency matches the integer multiples of the intrinsic subthreshold oscillation frequency of H-H neuron. Particularly, we find the multiple-coherence resonance depending on frequency of time-periodic coupling strength at the optimal noise intensity. We also obtain a resonance-like dependence of temporal coherence on the amplitude of time-periodic coupling strength. Additionally, we investigate the effects of average degree on the temporal coherence and find that the temporal coherence exhibits a resonance-like behavior with respect to the network average degree, indicating that the best regularity requires an optimal average degree.

  13. Traveling-wave solutions of a modified Hodgkin-Huxley type neural model via Novel analytical results for nonlinear transmission lines with arbitrary I(V characteristics

    Directory of Open Access Journals (Sweden)

    Valentino Anthony Simpao

    2000-01-01

    Full Text Available Herein an enhanced Hodgkin-Huxley (H-H type model of neuron dynamics is solved analytically via formal methods. Our model is a variant of an earlier one by M.A. Mahrous and H.Y. Alkahby [1]. Their modified model is realized by a hyperbolic quasi-linear diffusion operator with time-delay parameters; this compared to the original H-H model with standard parabolic quasi-linear diffusion operator and no time-delay parameters. Besides these features, the present model also incorporates terms describing signal dissipation into the background substrate (e.g., conductance to ground, making it more experimentally amenable. The solutions which results via the present scheme are of traveling-wave profile, which agree qualitatively with those observed in actual electro-physiological measurements made on the neural systems originally studied by H-H These results confirm the physiological soundness of the enhanced model and of the preliminary assumptions which motivated the present solution strategy; the comparison of the present results with actual electro-physiological data displays shall appear in later publications.

  14. On the concept of eugenics: preliminaries to a critical appraisal Sobre o conceito de eugenia: preliminares à uma avaliação crítica

    Directory of Open Access Journals (Sweden)

    Demetrio Neri

    1999-01-01

    Full Text Available This paper's main issue is linked to what can be foreseen as the increasing capability of medical genetics to modify the genetic composition of the human species through direct interventions in the human genome for medical and non-medical purposes, i.e., the 'risk' of a resurgence of eugenics. In current discussions on the topic (briefly presented in the first section, the 'phantom of eugenics' is raised several times, but there is a great deal of confusion on what counts as eugenics, partly because of broad conceptual disagreement over the notion itself. Furthermore, according to some scholars there is no hope of overcoming this unsatisfactory conceptual uncertainty. Partly challenging this opinion, the second and third sections of this paper attempt to identify some basic features which could be seen as intrinsically linked to the notion of eugenics, with the aim of reducing the range of conceptual disagreement as a preliminary step in bringing into focus what exactly is wrong with practicing eugenics. The subsequent sections deal with the substantive issue of whether or not to practice eugenics from the point of view of the interest of future generations in the human species' genetic composition. The main moral arguments for and against eugenics are examined from the point of view of our obligations towards future generations, and the conclusion is in favor of a cautious 'open-door' position.O ponto principal desse artigo está vinculado ao que pode ser antevisto como a crescente capacidade da genética médica de modificar a espécie humana por meio de intervenções diretas no genoma humano com propósitos médicos e não médicos, isto é, o risco do ressurgimento da eugenia. Nas atuais discussões sobre o tópico, o fantasma da eugenia é levantado diversas vezes, mas há grande confusão no que se refere ao que é considerado como eugenia, particularmente em razão da ampla discordância sobre a noção em si. Procura-se identificar

  15. Prostitutes and criminals: beginnings of eugenics in Croatia in the works of Fran Gundrum from Oriovac (1856-1919).

    Science.gov (United States)

    Kuhar, Martin; Fatović-Ferencić, Stella

    2012-04-01

    Fran Gundrum (1856-1919) was a Croatian physician, encyclopedist, and an advocate of medical enlightenment and healthy lifestyle. In order to identify and analyze Gundrum's ideas about the problems of prostitution and criminality, we studied all of his books, booklets, and articles published between 1905 and 1914. We showed that Gundrum's theories of heredity, morality, and sexual hygiene incorporated many of the important discussions of his time, especially those related to the Darwinian paradigm. Gundrum's project of collecting statistics on prostitutes was the first such study published on the territory of today's Croatia. Although he rejected the notions of born prostitutes and born criminals, defended by Italian criminal anthropologist Cesare Lombroso, he still regarded eugenics as a convenient method of dealing with the ills of society. He believed that criminals were degenerate individuals representing a violent threat to the society and that it was legitimate to use radical means, such as sterilization and deportation, to deal with this problem. Organicistic view of the society prevented him from seeing the individual rights as important as that of the society to protect itself. Nevertheless, this view led to many humanistic ideas, such as the binomial illness/poverty in case of prostitution, which influenced many prominent works of social medicine movement.

  16. 论古代斯巴达的优生政策%On the Eugenics Policy in Ancient Sparta

    Institute of Scientific and Technical Information of China (English)

    李怡净; 罗文君

    2014-01-01

    As a national policy, the eugenics policy in ancient Sparta is a true description of its national problems and is also the base rooted in the Greek world. It brings Sparta a powerful army to make Sparta dominate the Greek world. However, because of the ignorance of humanity development, Sparta’ culture is serious lag, which makes it suffer a eclipse in the bright Greek culture.%作为一项国策,古代斯巴达的优生政策是其国家所面临的城邦问题的真实反映,也是其立足于希腊世界的根本。优生政策为斯巴达打造了一支强大的军队,使其能称霸希腊世界,但由于忽视人性发展,斯巴达文化严重滞后,使其在辉煌灿烂的古代希腊文化中黯然失色。

  17. [Inception of institutionalization of clinical neurology in Munich (1913-1933): with particular focus on Eugen von Malaisé].

    Science.gov (United States)

    Voss, H

    2015-02-01

    At the University of Munich the teaching and treatment of neurological diseases had been covered by internists since the last quarter of the nineteenth century. Under the direction of Bumke the psychiatric clinic also laid claim to the representation of neurology starting in 1924. However, the military departments for nerve- and brain-injured soldiers, which were founded during WWI, developed into non-academic neurological treatment centres in Munich with donations from the German-American philanthropist Heckscher and the initiative of war invalids organisations. In 1925 the Heckscher Nerven-Heil- und Forschungsanstalt was established as the first neurological hospital in Munich. The main characters involved in this development were the neurologist Eugen von Malaisé and the psychiatrist Max Isserlin. With the early death of von Malaisé in 1923 neurology in Munich lost an important advocate of its institutional independence. The dismissal, prosecution and expulsion of the Jewish chief physician Isserlin was the second heavy blow to the efforts towards autonomy of neurology in Munich.

  18. 孕前优生健康教育对促进乡镇居民优生优育的作用探讨%Discussion of the effect of progestation eugenics health education on promoting villages and towns eugenic and superior nurture

    Institute of Scientific and Technical Information of China (English)

    宋新红

    2014-01-01

    Objective:To discuss the effect of progestation eugenics health education on promoting villages and towns eugenic and superior nurture.Methods:200 cases of newly married couples were selected as the test objects.They were divided into the experimental group and the control group with 100 cases in each according to the random numbers sampling principle.The knowledge of eugenic and superior nurture,pregnancy health knowledge,birth defect were as the comparative and analytical indicators.Results:By comparison,the differences between the two groups were significant in normal pregnancy physiological process,sexual knowledge,prenatal care and nutrition,contraception,birth defects prevention and other aspects(P<0.05). Conclusion:The progestation eugenics health education of newly married couples can improve the understanding of eugenic and superior nurture of both sides,strengthen the sexual health awareness,and prevente the occurrence of defects,so as to promote villages and towns eugenic and superior nurture education.%目的:探讨孕前优生健康教育对促进乡镇居民优生优育的影响。方法:选取200例新婚夫妇作为试验对象,并按照随机编号抽样的原则,将其分为试验组与对照组,各100例,并以对优生优育知识了解、孕前健康知识了解、出生缺陷了解等作为比较分析指标。结果:通过试验对比,两组在了解正常受孕生理过程、性知识、孕期保健与营养、避孕、出生缺陷预防等方面差异有统计学意义(P<0.05)。结论:通过对新婚夫妇在孕前的优生健康教育,可提高双方优生优育的认识,并加强在两性方面的保健意识,预防缺陷儿的发生,从而促进乡镇居民优生优育方面的教育。

  19. Eugenia negativa e positiva: significados e contradições Eugenesia negativa y positiva: significados y contradicciones Negative and positive eugenics: meanings and contradictions

    Directory of Open Access Journals (Sweden)

    Lilian Denise Mai

    2006-04-01

    Full Text Available A prática da eugenia constitui importante tema de debate associado aos atuais avanços biogenéticos. Considerando que a centralidade da eugenia é a preocupação com a saúde e constituição das futuras gerações, e que a utilização de meios e conhecimentos científicos em prol do nascimento de uma criança física e mentalmente saudável pode ser considerada uma ação eugênica, pretende-se, nesse texto, analisar significados e contradições das ações eugenistas negativas e positivas, construídos concomitantes aos avanços técnico-científicos do século XX. Conclui-se que os significados transitam, respectivamente, em torno de limitar ou estimular a reprodução humana, no início do século, até prevenir doenças ou melhorar características físicas e mentais, na atualidade. Implementando ações, produziram-se contradições, como a discriminação e eliminação de muitas pessoas frente a um ideal de homem, à biologização de fatores eminentemente sociais, à defesa da pretensa neutralidade científica e ao uso indiscriminado do direito de escolha reprodutiva.La práctica de la eugenesia es un importante tema de debate, ligado a los avances biogenéticos actuales. Considerando que la cuestión central de la eugenesia es la preocupación con la salud y la constitución de las futuras generaciones y que la utilización de medios y conocimientos científicos en función del nacimiento de un niño física y mentalmente saludable puede ser considerada una acción eugenésica, en este texto se pretende analizar los significados y contradicciones de las acciones eugenésicas negativas y positivas, construidos concomitantes a los avances técnico-científicos del siglo XX. Se concluye que los significados giran, respectivamente, en torno de limitar o estimular la reproducción humana, al comienzo del siglo, hasta prevenir enfermedades o mejorar características físicas y mentales, en la actualidad. Implementando acciones, se

  20. Eugenics ideals, racial hygiene, and the emigration process of German-American neurogeneticist Franz Josef Kallmann (1897-1965).

    Science.gov (United States)

    Pow, Stephen; Stahnisch, Frank W

    2016-01-01

    Biological psychiatry in the early twentieth century was based on interrelated disciplines, such as neurology and experimental biology. Neuropsychiatrist Franz Josef Kallmann (1897-1965) was a product of this interdisciplinary background who showed an ability to adapt to different scientific contexts, first in the field of neuromorphology in Berlin, and later in New York. Nonetheless, having innovative ideas, as Kallmann did, could be an ambiguous advantage, since they could lead to incommensurable scientific views and marginalization in existing research programs. Kallmann followed his Dr. Med. degree (1919) with training periods at the Charité Medical School in Berlin under psychiatrist Karl Bonhoeffer (1868-1948). Subsequently, he collaborated with Ernst Ruedin (1874-1952), investigating sibling inheritance of schizophrenia and becoming a protagonist of genetic research on psychiatric conditions. In 1936, Kallmann was forced to immigrate to the USA where he published The Genetics of Schizophrenia (1938), based on data he had gathered from the district pathological institutes of Berlin's public health department. Kallmann resumed his role as an international player in biological psychiatry and genetics, becoming president (1952) of the American Society of Human Genetics and Director of the New York State Psychiatric Institute in 1955. While his work was well received by geneticists, the idea of genetic differences barely took hold in American psychiatry, largely because of émigré psychoanalysts who dominated American clinical psychiatry until the 1960s and established a philosophical direction in which genetics played no significant role, being regarded as dangerous in light of Nazi medical atrocities. After all, medical scientists in Nazi Germany had been among the social protagonists of racial hygiene which, under the aegis of Nazi philosophies, replaced medical genetics as the basis for the ideals and application of eugenics.

  1. A self-organizing state-space-model approach for parameter estimation in hodgkin-huxley-type models of single neurons.

    Science.gov (United States)

    Vavoulis, Dimitrios V; Straub, Volko A; Aston, John A D; Feng, Jianfeng

    2012-01-01

    Traditional approaches to the problem of parameter estimation in biophysical models of neurons and neural networks usually adopt a global search algorithm (for example, an evolutionary algorithm), often in combination with a local search method (such as gradient descent) in order to minimize the value of a cost function, which measures the discrepancy between various features of the available experimental data and model output. In this study, we approach the problem of parameter estimation in conductance-based models of single neurons from a different perspective. By adopting a hidden-dynamical-systems formalism, we expressed parameter estimation as an inference problem in these systems, which can then be tackled using a range of well-established statistical inference methods. The particular method we used was Kitagawa's self-organizing state-space model, which was applied on a number of Hodgkin-Huxley-type models using simulated or actual electrophysiological data. We showed that the algorithm can be used to estimate a large number of parameters, including maximal conductances, reversal potentials, kinetics of ionic currents, measurement and intrinsic noise, based on low-dimensional experimental data and sufficiently informative priors in the form of pre-defined constraints imposed on model parameters. The algorithm remained operational even when very noisy experimental data were used. Importantly, by combining the self-organizing state-space model with an adaptive sampling algorithm akin to the Covariance Matrix Adaptation Evolution Strategy, we achieved a significant reduction in the variance of parameter estimates. The algorithm did not require the explicit formulation of a cost function and it was straightforward to apply on compartmental models and multiple data sets. Overall, the proposed methodology is particularly suitable for resolving high-dimensional inference problems based on noisy electrophysiological data and, therefore, a potentially useful tool in

  2. 赫胥黎与达尔文主义及生态伦理学的创新%Huxley and His Innovation of Darwinism and Ecological Ethics

    Institute of Scientific and Technical Information of China (English)

    何毓德; 郎补俄

    2012-01-01

    赫胥黎对生物进化论作出划时代创新。他汲取古希腊赫拉克利特的直观辩证法,使康德宇宙整体发展观推陈出新。从人类发生学和人猿比较解剖学新视角,重新确定了人在生物界中的位置,使达尔文的人猿同祖论,从"假说"深化为科学的结论。他看到人类社会和生物进化的差别,纠正了社会达尔文主义的错误。他把猿与具有"至善伦理"的人和生物进化相统一,赋予人类保护生态系统义不容辞的社会责任。他由此成为生态伦理学说的开拓者。%Huxley made epoch-making innovations of biological evolution. He absorbed the visual dia- lectics of Heraclitus of ancient Greece and developed new ideas out of Kant's whole development view of the universe. He redefined the position of man in the biological world from the new perspective of the origin of human species and the comparative anatomy of human species and apes, and therefore turned Darwin's theory of human and ape evolving from the same origin from hypothesis to scientific conclusion. He perceived the evolution differences between human society and biological creatures, and corrected the mistakes of social Darwinism. He integrated apes, man who has ethics and biological evolution, granting human beings the social responsibility of protecting ecological systems. Thus he became a pioneer of ecological ethics.

  3. Impact of Bounded Noise and Rewiring on the Formation and Instability of Spiral Waves in a Small-World Network of Hodgkin-Huxley Neurons.

    Science.gov (United States)

    Yao, Yuangen; Deng, Haiyou; Ma, Chengzhang; Yi, Ming; Ma, Jun

    2017-01-01

    Spiral waves are observed in the chemical, physical and biological systems, and the emergence of spiral waves in cardiac tissue is linked to some diseases such as heart ventricular fibrillation and epilepsy; thus it has importance in theoretical studies and potential medical applications. Noise is inevitable in neuronal systems and can change the electrical activities of neuron in different ways. Many previous theoretical studies about the impacts of noise on spiral waves focus an unbounded Gaussian noise and even colored noise. In this paper, the impacts of bounded noise and rewiring of network on the formation and instability of spiral waves are discussed in small-world (SW) network of Hodgkin-Huxley (HH) neurons through numerical simulations, and possible statistical analysis will be carried out. Firstly, we present SW network of HH neurons subjected to bounded noise. Then, it is numerically demonstrated that bounded noise with proper intensity σ, amplitude A, or frequency f can facilitate the formation of spiral waves when rewiring probability p is below certain thresholds. In other words, bounded noise-induced resonant behavior can occur in the SW network of neurons. In addition, rewiring probability p always impairs spiral waves, while spiral waves are confirmed to be robust for small p, thus shortcut-induced phase transition of spiral wave with the increase of p is induced. Furthermore, statistical factors of synchronization are calculated to discern the phase transition of spatial pattern, and it is confirmed that larger factor of synchronization is approached with increasing of rewiring probability p, and the stability of spiral wave is destroyed.

  4. Impact of Bounded Noise and Rewiring on the Formation and Instability of Spiral Waves in a Small-World Network of Hodgkin-Huxley Neurons

    Science.gov (United States)

    Yao, Yuangen; Deng, Haiyou; Ma, Chengzhang; Yi, Ming

    2017-01-01

    Spiral waves are observed in the chemical, physical and biological systems, and the emergence of spiral waves in cardiac tissue is linked to some diseases such as heart ventricular fibrillation and epilepsy; thus it has importance in theoretical studies and potential medical applications. Noise is inevitable in neuronal systems and can change the electrical activities of neuron in different ways. Many previous theoretical studies about the impacts of noise on spiral waves focus an unbounded Gaussian noise and even colored noise. In this paper, the impacts of bounded noise and rewiring of network on the formation and instability of spiral waves are discussed in small-world (SW) network of Hodgkin-Huxley (HH) neurons through numerical simulations, and possible statistical analysis will be carried out. Firstly, we present SW network of HH neurons subjected to bounded noise. Then, it is numerically demonstrated that bounded noise with proper intensity σ, amplitude A, or frequency f can facilitate the formation of spiral waves when rewiring probability p is below certain thresholds. In other words, bounded noise-induced resonant behavior can occur in the SW network of neurons. In addition, rewiring probability p always impairs spiral waves, while spiral waves are confirmed to be robust for small p, thus shortcut-induced phase transition of spiral wave with the increase of p is induced. Furthermore, statistical factors of synchronization are calculated to discern the phase transition of spatial pattern, and it is confirmed that larger factor of synchronization is approached with increasing of rewiring probability p, and the stability of spiral wave is destroyed. PMID:28129401

  5. The Space-Clamped Hodgkin-Huxley System with Random Synaptic Input: Inhibition of Spiking by Weak Noise and Analysis with Moment Equations.

    Science.gov (United States)

    Tuckwell, Henry C; Ditlevsen, Susanne

    2016-10-01

    We consider a classical space-clamped Hodgkin-Huxley model neuron stimulated by synaptic excitation and inhibition with conductances represented by Ornstein-Uhlenbeck processes. Using numerical solutions of the stochastic model system obtained by an Euler method, it is found that with excitation only, there is a critical value of the steady-state excitatory conductance for repetitive spiking without noise, and for values of the conductance near the critical value, small noise has a powerfully inhibitory effect. For a given level of inhibition, there is also a critical value of the steady-state excitatory conductance for repetitive firing, and it is demonstrated that noise in either the excitatory or inhibitory processes or both can powerfully inhibit spiking. Furthermore, near the critical value, inverse stochastic resonance was observed when noise was present only in the inhibitory input process. The system of deterministic differential equations for the approximate first- and second-order moments of the model is derived. They are solved using Runge-Kutta methods, and the solutions are compared with the results obtained by simulation for various sets of parameters, including some with conductances obtained by experiment on pyramidal cells of rat prefrontal cortex. The mean and variance obtained from simulation are in good agreement when there is spiking induced by strong stimulation and relatively small noise or when the voltage is fluctuating at subthreshold levels. In the occasional spike mode sometimes exhibited by spinal motoneurons and cortical pyramidal cells, the assumptions underlying the moment equation approach are not satisfied. The simulation results show that noisy synaptic input of either an excitatory or inhibitory character or both may lead to the suppression of firing in neurons operating near a critical point and this has possible implications for cortical networks. Although suppression of firing is corroborated for the system of moment equations

  6. Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.

    Directory of Open Access Journals (Sweden)

    Björn Friedrich

    Full Text Available HYPOTHESIS: Serum- and Glucocorticoid-inducible Kinase 1 (SGK1 is involved in the regulation of insulin secretion and may represent a candidate gene for the development of type 2 diabetes mellitus in humans. METHODS: Three independent European populations were analyzed for the association of SGK1 gene (SGK variations and insulin secretion traits. The German TUEF project provided the screening population (N = 725, and four tagging SNPs (rs1763527, rs1743966, rs1057293, rs9402571 were investigated. EUGENE2 (N = 827 served as a replication cohort for the detected associations. Finally, the detected associations were validated in the METSIM study, providing 3798 non-diabetic and 659 diabetic (type 2 individuals. RESULTS: Carriers of the minor G allele in rs9402571 had significantly higher C-peptide levels in the 2 h OGTT (+10.8%, p = 0.04; dominant model and higher AUC(C-Peptide/AUC(Glc ratios (+7.5%, p = 0.04 compared to homozygous wild type TT carriers in the screening population. As interaction analysis for BMIxrs9402571 was significant (p = 0.04 for the endpoint insulin secretion, we stratified the TUEF cohort for BMI, using a cut off point of BMI = 25. The effect on insulin secretion only remained significant in lean TUEF participants (BMI< or =25. This finding was replicated in lean EUGENE2 rs9402571 minor allele carriers, who had a significantly higher AUC(Ins/AUC(Glc (TT: 226+/-7, XG: 246+/-9; p = 0.019. Accordingly, the METSIM trial revealed a lower prevalence of type 2 diabetes (OR: 0.85; 95%CI: 0.71-1.01; p = 0.065, dominant model in rs9402571 minor allele carriers. CONCLUSIONS: The rs9402571 SGK genotype associates with increased insulin secretion in lean non-diabetic TUEF/EUGENE2 participants and with lower diabetes prevalence in METSIM. Our study in three independent European populations supports the conclusion that SGK variability affects diabetes risk.

  7. Reviews.

    Science.gov (United States)

    Greenleaf, Floyd; And Others

    1986-01-01

    Reviews eight textbooks, readers, and books. Topics include Latin America, colonial America, the Carolinians, women in French textbooks, the Vikings, the Soviet Union, nineteenth-century Black America, and Ernest Rutherford. (TRS)

  8. Reviews.

    Science.gov (United States)

    Science Teacher, 1987

    1987-01-01

    Provides reviews of four computer software packages designed for use in science education. Describes courseware dealing with a variety of tips for teaching physics concepts, chemical reactions in an aqueous solution, mitosis and meiosis, and photosynthesis. (TW)

  9. Review

    African Journals Online (AJOL)

    2016-01-01

    Jan 1, 2016 ... medicine and biology here an attempt has been made to review the synthesis and biological ... insight into the recent applications of Mannich reaction and its ...... Various thermodynamic parameters were also determined to ...

  10. Electra sob as luzes da ribalta: ação e ethos trágico em Mourning Becomes Electra, de Eugene O'Neill

    OpenAIRE

    Sousa, Alexandre de Albuquerque

    2014-01-01

    Esta pesquisa tem por objetivo analisar a ação dramática e o ethos trágico dos personagens na trilogia Mourning Becomes Electra, tendo como foco a protagonista Lavínia Mannon. Escrita pelo dramaturgo norte-americano Eugene O Neill e encenada, pela primeira vez, em 1931, a trilogia escolhida como corpus desta pesquisa constitui-se uma releitura da Oréstia, de Ésquilo, cujo enredo apresenta uma apropriação do mito dos Atridas, família cuja história é marcada por crimes de ódio e ...

  11. Reviews

    Directory of Open Access Journals (Sweden)

    1990-06-01

    Full Text Available Michael Issacharoff. Discourse as Performance . Stanford: Stanford University Press, 1989. vii + 161 pp. Reviewed by Gerald Prince, University of Pennsylvania Thomas M. Kavanagh, ed. The Limits of Theory . Stanford: Stanford University Press, 1989. 254 pp. Reviewed by André J.M. Prévos, Pennsylvania State University, Worthington Scranton Campus Wendy B. Faris. Labyrinths of Language: Symbolic Landscape and Narrative Design in Modern Fiction . Baltimore and London: The Johns Hopkins Press, 1988. 242 pp. Reviewed by Carol Rigolot, Princeton University Eve Tavor Bannet. Structuralism and the Logic of Dissent: Barthes, Derrida, Foucault, Lacan . Urbana and Chicago: University of Illinois Press, 1989. 299 pp. Reviewed by Andrew J. McKenna, Loyoyla University of Chicago Gary Saul Morson and Caryl Emerson, eds. Rethinking Bakhtin: Extensions and Challenges . Evanston: Northwestern University Press, 1989. Reviewed by Lewis Bagby, University of Wyoming Fernando Moreno. Carlos Fuentes. La mort d'Artemio Cruz: entre le mythe et l'histoire . Paris: Editions Caribeennes, 1989. Reviewed by Susan Levine, Lawrence, Kansas

  12. Diseases and remedies in modern city: environmental perspectives of argentinian eugenism between the mundial wars

    Directory of Open Access Journals (Sweden)

    Vallejo, Gustavo

    2007-06-01

    Full Text Available During the inter - war period it consolidate in Argentina a tendency to pathologize the modern city, understood like an ill organism that produced and was consequence phisical and moral decadency
    of its habitants. The interruption of external inmigration contributed with new information for a strategy of regeneration that tried to establish from eugenesics directed to articulate the populationism with the territorial distribution, in the certainty that counteracted country the evils that generated the life modern. The work reviews the impact of this ideology in the different spheres and the way in which has integrated the cultural politic of the fascism and taked part of the corpus with which the biotipology looked to give scientific legitimacy.

    Durante el período de entreguerras se consolidó en Argentina una tendencia a patologizar la ciudad moderna, entendida como un organismo enfermo que producía y a su vez era consecuencia de la decadencia física y moral de sus habitantes. La interrupción de la inmigración externa aportó nuevos datos para una estrategia de regeneración que pugnó por establecer, desde la eugenesia, medidas dirigidas a articular el poblacionismo con la distribución territorial, en la certeza de que el campo contrarrestaría los males que generaba la vida moderna. El trabajo repasa el impacto de esta ideología en distintas esferas y el modo en que ella se recepcionó junto a la política cultural del fascismo y formó parte del corpus con el que la biotipología buscó darle legitimidad científica.

  13. Review of Army Officer Educational System. Volume 2. Full Report, and Annexes B, C

    Science.gov (United States)

    1971-12-01

    reviews which deal with the premises and fundamentals 3 This view is strongly expressed by Edward L. Katzenbach , Jr. in "The Demotion of Professionalism...Munitions School, US Army Logistics Management Center, US Army Combat Surveillance and Electronic Warfare School, US Army John F. Kennedy Institute...of Oregon 145 Moore Hall 147B Hendricks Hall Los Angeles, California 90024 Eugene, Oregon 97403 213-825-4711, Ext. 28 503-686-5172 Dr. John Holland

  14. Reviews

    OpenAIRE

    Revista alicantina de estudios ingleses

    1995-01-01

    Contiene: M. Carmen África Vidal Claramonte. Traducción, manipulación, desconstrucción. Colección Biblioteca Filológica de Salamanca. Salamanca: Ediciones Colegio de España, 1995 / reviewed by Enrique Alcaraz Varó; Diccionario de uso inglés-español/Spanish-English. Directed by Aquilino Sánchez. Madrid: SGEL, 1993, 450 pp. Diccionario de uso pocket inglés-español/Spanish- English. Directed by Aquilino Sánchez. Madrid: SGEL, 1993, 274 pages / reviewed by Miguel Ángel Campos Pardillo...

  15. Reviews.

    Science.gov (United States)

    Journal of Chemical Education, 1988

    1988-01-01

    Reviews three computer software packages for chemistry education including "Osmosis and Diffusion" and "E.M.E. Titration Lab" for Apple II and "Simplex-V: An Interactive Computer Program for Experimental Optimization" for IBM PC. Summary ratings include ease of use, content, pedagogic value, student reaction, and…

  16. Reviews

    NARCIS (Netherlands)

    Sleumer, H.; Steenis, van C.G.G.J.

    1966-01-01

    An exhaustive Flora of Delhi, compiled by J. K. Maheshwari, was published by C.S.I.R. in 1963 (for a review see Blumea 13, 1965, p. 174). During the compilation of that flora, 278 line-drawings, illustrating the habits and chief features of the plants found in Delhi, were prepared; they form a welco

  17. Reviews

    NARCIS (Netherlands)

    NN,

    1998-01-01

    BALGOOY, M.M.J, VAN. 1998. Malesian Seed Plants. Volume 2. Portraits of tree families. 307 pp., numerous text figures. Published by Rijksherbarium/Hortus Botanicus, Leiden. ISBN 90-71236-36-6. Paperback. Price: NLG 100.00. This is the second volume of a trilogy [see the review of ‘Spot-characters’ b

  18. Reviews.

    Science.gov (United States)

    Repak, Arthur J.; And Others

    1988-01-01

    Computer software, audiovisuals, and books are reviewed. Includes topics on interfacing, ionic equilibrium, space, the classification system, Acquired Immune Disease Syndrome, evolution, human body processes, energy, pesticides, teaching school, cells, and geological aspects. Availability, price, and a description of each are provided. (RT)

  19. Review

    DEFF Research Database (Denmark)

    Van Den Hazel, H B; Kielland-Brandt, Morten; Winther, Jakob R.

    1996-01-01

    The yeast vacuole, which is equivalent to the lysosome of higher eukaryotes, is one of the best characterized degradative organelles. This review describes the biosynthesis and function of yeast vacuolar proteases. Most of these enzymes are delivered to the vacuole via the early compartments...

  20. Review

    NARCIS (Netherlands)

    Wilde, de W.J.J.O.

    1994-01-01

    This review marks the appearance of Volume II, after the publication of Volume I, Pteridophytes and Gymnosperms, in 1990; several more volumes are expected in the future before completion of the Vascular plants as a whole. The present volume contains 73 families out of some 250-500 families which ca

  1. Reviews

    NARCIS (Netherlands)

    Adema, Frits

    1995-01-01

    This is the second volume of a revision of Tabernaemontana (Apocynaceae). The volume covers the New World species (44) and the genus Stemmadenia (10 species). This part of the revision of Tabernaemontana comes up to the high standards set in the first volume [see the review by Leenhouts, Blumea 38 (

  2. ["A decision meaning a new foundation...": from the Kaiser Wilhelm Institute for Anthropology, Human Genetics and Eugenics to the Max Planck Institute for Molecular Genetics].

    Science.gov (United States)

    Sachse, Carola

    2011-01-01

    The Max Planck Institute for Molecular Genetics (MPIMG) in Berlin-Dahlem dates its establishment to 1964. Its homepage makes no mention of its predecessor institutes, the Kaiser Wilhelm Institute for Anthropology, Human Genetics and Eugenics (KWIA) and the subsequent MPI for Comparative Genetics and Hereditary Pathology (MPIVEE). This article traces the two critical phases of transition regarding the constellations of academic staff, institutional and epistemic ruptures and continuities specific to the era. Only one of the five department heads from the final war years, Hans Nachtsheim, remained a researcher within the Max Planck Society (MPG); he nevertheless continued to advocate the pre-war and wartime eugenic agenda in the life sciences and social policy. The generational change of 1959/60 became a massive struggle within the institute, in which microbial genetics (with Fritz Kaudewitz) was pitted against human genetics (with Friedrich Vogel) and managed to establish itself after a fresh change in personnel in 1964/65. For the Dahlem institute, this involved a far-reaching reorientation of its research, but for the genetically oriented life sciences in the Max Planck Society as a whole it only meant that molecular biology, which was already being pursued in the West German institutes, gained an additional facility. With this realignment of research traditions, the Society was able to draw a line under the Nazi past without having to address it head-on.

  3. Ernst Rüdin's Unpublished 1922-1925 Study "Inheritance of Manic-Depressive Insanity": Genetic Research Findings Subordinated to Eugenic Ideology.

    Science.gov (United States)

    Kösters, Gundula; Steinberg, Holger; Kirkby, Kenneth Clifford; Himmerich, Hubertus

    2015-11-01

    In the early 20th century, there were few therapeutic options for mental illness and asylum numbers were rising. This pessimistic outlook favoured the rise of the eugenics movement. Heredity was assumed to be the principal cause of mental illness. Politicians, scientists and clinicians in North America and Europe called for compulsory sterilisation of the mentally ill. Psychiatric genetic research aimed to prove a Mendelian mode of inheritance as a scientific justification for these measures. Ernst Rüdin's seminal 1916 epidemiological study on inheritance of dementia praecox featured large, systematically ascertained samples and statistical analyses. Rüdin's 1922-1925 study on the inheritance of "manic-depressive insanity" was completed in manuscript form, but never published. It failed to prove a pattern of Mendelian inheritance, counter to the tenets of eugenics of which Rüdin was a prominent proponent. It appears he withheld the study from publication, unable to reconcile this contradiction, thus subordinating his carefully derived scientific findings to his ideological preoccupations. Instead, Rüdin continued to promote prevention of assumed hereditary mental illnesses by prohibition of marriage or sterilisation and was influential in the introduction by the National Socialist regime of the 1933 "Law for the Prevention of Hereditarily Diseased Offspring" (Gesetz zur Verhütung erbkranken Nachwuchses).

  4. Reviews

    Directory of Open Access Journals (Sweden)

    Wilma D'Ambrosio

    2013-12-01

    Full Text Available In the wake of the great interest raised by Maurizio Gabrieli’s review of the book Musical Networks. Parallel Distributed Perception and Performance (various authors; edited by Niall Griffith and Peter M. Todd, MA: MIT Press, Cambridge, 1999 which appeared in our last issue of Analitica, the present review section no longer follows the format used up to now but offers a survey of texts dedicated to the relationship between music analysis and technology. This decision was also made as a result of the request for more information on the subject by many of our readers. In coming issues we plan to extend this bibliography and comment on at least some of the most interesting texts published in recent years, among which we would immediately like to draw attention to the important work by Baroni, Dalmonte and Jacoboni published in 1999 (Le regole della musica. Indagine sui meccanismi della comunicazione, Torino, I Manuali EDT/SIdM, 1999.

  5. Reviews

    Directory of Open Access Journals (Sweden)

    Philip Barker

    1998-12-01

    Full Text Available There were two copy-editing blunders in Clive Betts's review, in ALT-J 5 (3, of Shirley Fletcher's Designing Competence-Based Training, one in paragraph 2 line 1, the other in paragraph 3 line 8. The errors (the result of the Editor, Gabriel Jacobs, trying to perform a final proof of the journal at lightning speed in order to meet the printing deadline, and not of any mistake on the part of either Philip Barker or the University of Wales Press hardly affected meaning, but the fact that they appeared in a review of a book on competence makes the embarrassment all the more telling. The Editor apologizes, and thanks eagle-eyed readers. He has decided to read the book in the hope that such errors will not recur.

  6. Reviews

    Directory of Open Access Journals (Sweden)

    Philip Barker

    1997-12-01

    Full Text Available For a variety of different reasons, increasing use is now being made of the Internet for the delivery of course materials and/or for the support of teaching and learning activities. The details of the mechanisms used will obviously vary from one situation to another, depending upon the types of problem to be addressed. These may involve mentoring, teaching, monitoring, recording, tutoring, assessing, and so on. In this book, the author attempts to review the educational and administrative considerations of offering courses, course materials or course delivery via the Internet.

  7. REVIEW

    Directory of Open Access Journals (Sweden)

    N. F. Bugay

    2016-01-01

    Full Text Available Review of Study Guide: «KUBAN STUDIES. KUBAN IN THE XX CENTURY – THE BEGINNING OF THE XXI CENTURY. HISTORY. PEOPLE SOCIETY.» Study Guide (electronic version to grade 11 of educational institutions. A.A. Zaitsev, E.V. Morozova, N.V. Plotichkina and O.A. Borisko, M.A. Egupova, A.B. Sazantovich, I.S. Bashkakov, T.I. Belyaeva. Krasnodar: Perspectives on Education, 2015.In a review of a thorough analysis of all the component parts of the book that will surely attract the attention first of all history teachers and students in 11 classes of educational institutions of the region. A comprehensive presentation of the material significantly adds to the course of modern history of Russia and enrich its specific material about the life of the Russian Cossacks and as part of the – of the Kuban Cossacks. Along with the reference materials of pure nature that is needed for this kind of research are presented and informative sections on the socio-economic condition of the region, the interests of different strata of the population, the multinational factor and the religious beliefs of the population. Cossacks in its warlike mentality, and this trait is passed from generation to generation. But the aspirations of the Cossacks in this respect are transparent – protecting the integrity of the Fatherland, faithful service to him, boundless devotion to the Orthodox faith. The important story is linked with the identity of the Russian Cossacks, its mentality, "Kuban" specificity, especially for the rule on different sections of history, to various of its exponents, both military and civilians. As is known from the Cossacks received a development institute of judging for each Ataman smoking, working village judge. Cossacks series comply with the law as applied his own family, and chic plan – in the state, fought against offenders, it is considered in relation to the Cossacks and representatives of different ethnic communities living with the Cossacks, and

  8. 叔本华和尼采对奥尼尔悲剧的影响%The Influence Exerted by Schopenhauer and Nietzsche upon Eugene O'Neill

    Institute of Scientific and Technical Information of China (English)

    郑伟

    2011-01-01

    Eugene O'Neill is greatly influenced by Schopenhauer's The World as Will and Representation and his tragic thoughts and inherits his tragic theory.O'Neill thinks highly of Nietzsche's Superman,anti-religious thoughts as well as his tragic theory.Definitel%叔本华的唯意志论和他的悲剧思想对尤金·奥尼尔有着极大的影响,后者继承了前者的悲剧理论。尤金·奥尼尔对尼采的超人哲学和反宗教思想以及他的悲剧理论也是推崇备至并深受影响。

  9. Practical animal breeding as the key to an integrated view of genetics, eugenics and evolutionary theory: Arend L. Hagedoorn (1885-1953).

    Science.gov (United States)

    Theunissen, Bert

    2014-06-01

    In the history of genetics Arend Hagedoorn (1885-1953) is mainly known for the 'Hagedoorn effect', which states that part of the changes in variability that populations undergo over time are due to chance effects. Leaving this contribution aside, Hagedoorn's work has received scarcely any attention from historians. This is mainly due to the fact that Hagedoorn was an expert in animal breeding, a field that historians have only recently begun to explore. His work provides an example of how a prominent geneticist envisaged animal breeding to be reformed by the new science of heredity. Hagedoorn, a pupil of Hugo de Vries, tried to integrate his insights as a Mendelian geneticist and an animal breeding expert in a unified view of heredity, eugenics and evolution. In this paper I aim to elucidate how these fields were connected in Hagedoorn's work.

  10. The early eugenics movement and emerging professional psychiatry: conceptual transfers and personal relationships between Germany and North America, 1880s to 1930s.

    Science.gov (United States)

    Stahnisch, Frank W

    2014-01-01

    French-Austrian psychiatrist Bénédict Augustin Morel's (1809-1873) Traits des dégénérescences physiques, intellectuelles et morales de l'espèce humaine (1857) was fully dedicated to the social problem of "degeneration" and it became very attractive to German-speaking psychiatrists during the latter half of the 19th century. Auguste Forel (1848-1931) and Constantin von Monakow (1853-1930) in Zurich integrated Morel's approach and searched for the somatic and morphological alterations in the human brain; a perspective of research that Ernst Ruedin (1874-1952) at Munich further prolonged into a thorough analysis of hereditary influences on mental health. This paper investigates the continuities and major differences within some early eugenic traditions of the emerging field of psychiatry in the German-speaking countries and North America.

  11. [The general psychological concept in the later work of Eugen Bleulers. Comparison with a summarized description from a forgotten theory 60 years after the final publication (1939)].

    Science.gov (United States)

    Möller, A; Hell, D

    1999-04-01

    Documents by Eugen Bleuler from 1921 to 1939 that go into general psychological topics of meaning of consciousness, formation of motive and will, are presented. An effort towards integration of seemingly incompatible, side by side standing, unrelated biological and psychological concepts that probably is most likely explainable by the contemporary background of ideas, is recognizable. In this context, Eugen Bleuler refers to an already (especially by Richard Semon) systematically developed theory called "Mnemism" that he interpreted and applied to the psychological circumstances mentioned above. That theory of "mnemism" that can be most adequately described as a biogenetic-vitalistic theory, is assuming, that all organic life--independent of the possibility of a self-reflecting consciousness--is able to learn experiences made by analysis of environment and to pass it on following generations. Pattern of stimulus reactions are in the sense of this theory memorized ("engraphiert") and reactivated under similar situational circumstances ("ekphoriert") by the psychological mode of association.--It can be shown that Bleuler pursued this theory for a period of more than ten years. It represents the benchmark for Bleuler's standpoints, for example for the question of determination of human acting, that as itselves are already known from his earlier documents, but here have found a more theoretically based explanation. The assumption of the efficacy of specific, not necessary consciously remembered "engramms" of memory, suggests the hypothesis of the existence of unconsciousness; in this context textual points of contact to the psychological concepts of S. Freud and C. G. Jung--mnemic memory and collective unconscious--are shown.

  12. The Synchronization and Associative Memory of Hodgkin-Huxley Neural Network with Randomly Distributed Time Delays%随机延时Hodgkin-Huxley神经网络的同步与联想记忆

    Institute of Scientific and Technical Information of China (English)

    李冰; 彭建华; 刘延柱

    2005-01-01

    基于神经系统微观生理结构,给出具有空间分布随机延时的神经元间耦合,而这种随机延时描述峰电位从突触前神经元到突触后神经元在轴突上传播所需要的时间.记忆由时空发放的神经元集群表达.通过加入并改变噪声的强度,研究了噪声对Hodgkin-Huxley(HH)神经元网络系统联想记忆的作用,在噪声涨落的作用下,系统取得了对不完整输入的记忆恢复,得到与熟知的随机共振完全一致的结果.

  13. 外电场下Hodgkin-Huxley模型的分岔分析%Analysis of hopf bifurcation in the hodgkin-Huxley model exposed to external DC electric field

    Institute of Scientific and Technical Information of China (English)

    于凯; 赵辉; 王红君; 岳有军

    2009-01-01

    本文以Hodgkin-Huxley(HH)为基础,分析外电场对神经细胞的作用机制,建立了极低电场下改进的HH模型.我们通过高维系统Hopf分岔存在性的代数判据,计算了(外部刺激电流)和(外部直流电场引起的跨膜电压)的单参数空间的Hopf分岔集,并给出了系统产生稳定周期解的参数区域,这将有助于从理论上揭示和解释电场致病的生物机理,为预防和治疗此类疾病提供理论依据.

  14. The Cultural Roots of the Ancient Greek Tragedy in Eugene O’Neill’s Dramas%尤金·奥尼尔戏剧中的古希腊悲剧文化根源

    Institute of Scientific and Technical Information of China (English)

    赵攀

    2013-01-01

      尤金·奥尼尔的戏剧是对古希腊悲剧的批判与继承。文章从奥尼尔作品中的悲剧人物、悲剧主题和悲剧题材的根源出发,研究了尤金·奥尼尔作品中的悲剧文化根源——古希腊的悲剧文化。这为我们更好地欣赏尤金·奥尼尔作品,了解尤金·奥尼尔的古希腊悲剧文化特色奠定了基础。%  Eugene O’Neill’s dramas are a kind of criticism and inheritance of the ancient Greek tragedy. Ancient Greek tragedy is cultural roots in Eugene O’Neill’s tragedies from an analysis of its tragic figures, tragedy themes and its roots. It helps us appreciate Eugene O’Neill’s dramas better and learn more of his cultural features of ancient Greek tragedy.

  15. “优生学”有效教学的策略%The Tactics of Effective Teaching in"Eugenics"

    Institute of Scientific and Technical Information of China (English)

    范敏

    2014-01-01

    Eugenics is a comprehensive discipline aiming to im-prove the quality of population. This course includes a wide range of knowledge and rich content, and is a highly practical and sci-entific subject. There are many deficiencies and disadvantages of traditional teaching in this course. To improve"Eugenics"course teaching, this paper analyzed the method to integrate effective teaching to traditional teaching from the view of effective teaching theory. In this paper, we try to explore teaching reform from the aspects of setting correct teaching goals, selecting scientific and rational teaching contents, paying enough time for preparation, organizing teaching contents scientifically, establishing a harmo-nious relationship between teachers and students, and showing enthusiasm during teaching process. The change of teaching method has improved the teaching quality, and has achieved some teaching effects in practice.%“优生学”是提高人口素质的一门综合性学科,本课程包括的知识广泛、内容丰富,具有较强的实用性和科学性。传统“优生学”的教学中存在许多不足之处。为了完善“优生学”的教学,本文从有效教学的理论出发,分析了如何在传统教学中融入有效教学。笔者从制定正确的教学目标,选择科学合理的教学内容;开展充分的教学准备,进行科学合理的教学组织;建立融洽的师生关系,体现充满热情的教学过程等方面进行了教学改革的探索,提高了教学质量,取得了一定的教学效果。

  16. Analysis on the Effect of the Intervention on Health Eugenics Education to Childbearing Age Couples in Tibet Area%西藏地区育龄夫妇优生健康教育干预效果分析

    Institute of Scientific and Technical Information of China (English)

    陈瑞华; 吴芳; 肖丹; 李亚杰; 仁真; 董晓蓉; 匡雪莲

    2015-01-01

    Health eugenics education have been intervened on 2800 childbearing age couples with question-naires survey and the results of pre-intervention and post-intervention questionnaires were compared for scientif-ically to evaluate the intervention effect of health eugenics education curried in areas of birth defects-level one project by using convenience sampling method with 9 counties project undertaken in Tibet. The result showed that the differences in correct answer rate of eugenic knowledge before and after the intervention were statistical-ly significant (P<0.05), The accuracy of correct answer rate has been significantly improved after the interven-tion took place and the intervention effect on the health eugenics education of childbearing age couples was re-markable. Therefore, the reinforcement of raining village doctors and birth controlling staff on their eugenics sci-entific knowledge, and the individual counseling and education conducting to childbearing age couples by the op-portunities of health care before pregnancy and during the pregnancy have became the key for effective preven-tion of birth defects.%为科学评估西藏出生缺陷一级干预试点项目地区开展优生健康教育干预的效果,采用方便抽样方法,抽取西藏地区9个项目开展县,对户籍所在的2800对育龄夫妇进行优生健康教育干预,在干预前后进行问卷调查.结果显示,干预前后优生知识回答正确率差异均有统计学意义(P<0.05),干预后回答正确率明显提高,育龄夫妇优生健康教育干预效果显著.因此,加强对村医生及计生专干人员优生科学知识的培训,利用孕前和孕期保健机会,对育龄夫妇进行个体咨询和宣传教育,是预防出生缺陷的关键.

  17. Eugenia e Fundação Rockefeller no Brasil: a saúde como proposta de regeneração nacional Eugenics and the Rockefeller Foundation in Brazil: health as an instrument of national regeneration

    Directory of Open Access Journals (Sweden)

    Elisabete Kobayashi

    2009-12-01

    Full Text Available Nas primeiras décadas do século XX, a Fundação Rockefeller atuou de modo decisivo na implementação de ações voltadas para a saúde pública no Brasil, especialmente naquilo denominado de movimento sanitarista. Nesse mesmo período, a eugenia brasileira era equivalente ao sanitarismo, onde defendia-se a máxima de que "sanear era eugenizar". Vários trabalhos discutem o movimento sanitário, a questão da saúde pública no Brasil, a Fundação Rockefeller, a eugenia e seus ativistas. Entretanto, é escassa a discussão a respeito da Rockefeller e o movimento eugenista brasileiro. É necessário alertar que embora nos deparemos com questões ligadas à raça, teorias sobre genética ou evolução, este trabalho não tem como objetivo analisar tais assuntos com profundidade. O que buscamos construir foi o cenário no qual a eugenia de maneira geral, e a brasileira, especificamente, se desenrolou trazendo à tona as posturas de alguns eugenistas brasileiros.In the first decades of the twentieth century, the work of the Rockefeller Foundation was decisive for the implementation of public health initiatives in Brazil, especially in the so-called public health movement. At that time, Brazilian eugenics was the same as public health, as expressed in the maxim "to sanitize is to eugenize". There are several studies discussing the public health movement, the issue of public health in Brazil, the Rockefeller Foundation, eugenics and its supporters. However, there is little discussion on the relationship between the Rockefeller Foundation and the Brazilian eugenics movement. It is worth to mention that although there are issues related to race, and theories on genetics and evolution, this work does not intend to examine these issues in depth. The aim was to recreate the scenario in which eugenics in general, and particularly in the Brazilian case, was developed, exposing the positions of some of the Brazilian eugenicists.

  18. 20世纪上半叶美国优生运动的历史轨迹%A Historical Exploration of Eugenics Movement in the United States during the First Half of the 20th Century

    Institute of Scientific and Technical Information of China (English)

    侯波

    2014-01-01

    The American Eugenics Movement is a social movement launched and led by eugenicists from the early of the 20th century to 1940s in the name of eugenics .This movement focused on the propaganda to spread the knowledge of eugenics as well as on the making of eugenics laws and putting them into implementation .To be sure ,it was an active response of American eugenicists and their supporters to the social and demographic changes at the turning of the 20th century . However ,its philosophy and specific measures tended to be closely interwoven with racism ,nativism and other social prejudices ,which made the movement gradually become the tools of racial discrimination and social oppression .In the final analysis ,Eugenics Movement has not only made a lasting impact on American society ,but also provided a profound lesson in the history of science .%20世纪初至40年代的美国优生运动是一场在优生学名义下,由优生学家发起和领导的国内运动,其主要内容为宣扬优生知识、制定并实施优生立法。尽管这场运动是美国优生学家及其支持者们对19世纪末20世纪初美国社会及人口格局变化做出的积极回应,但它所宣扬的观念及其具体实践都融入了当时社会上所盛行的种族主义、排外主义以及其他偏见,使得这场运动逐渐沦为种族歧视和社会压迫的工具。时至今日,优生运动仍给美国社会带来了深远的影响,同时在科学发展史上留下了深刻的教训。

  19. 从分裂人格看尤金·奥尼尔的身份叙事%Fragmented Personality in Eugene O'Neill's Identity Narrative

    Institute of Scientific and Technical Information of China (English)

    陶久胜

    2012-01-01

    Eugene O'Neill's mid-stage plays fully show the flexibility of identity,challenge and deconstruct power discourse's provision of the nature and essence of identity,demonstrate the process of the changes of identity and the development of new identity."The Great God Brown"(1925) discloses Brown's divided and incoherent persona.In "Days without End"(1933) the dialogues between Loving's two divided selves illuminate the conflicts between ego and the id.%奥尼尔戏剧充分揭示身份的可塑性特征,挑战并解构权力话语对身份本质和本体特征的规定,演示了身份变化的过程。《大神布朗》揭示了布朗分裂的、非连贯的人格;《无穷岁月》中约翰.洛文两个分裂自我的对白实际上是相互矛盾的本我和自我的冲突。

  20. Human genetics and politics as mutually beneficial resources: The case of the Kaiser Wilhelm Institute for Anthropology, Human Heredity and Eugenics during the Third Reich.

    Science.gov (United States)

    Weiss, Sheila Faith

    2006-01-01

    This essay analyzes one of Germany's former premier research institutions for biomedical research, the Kaiser Wilhelm Institute for Anthropology, Human Heredity and Eugenics (KWIA) as a test case for the way in which politics and human heredity served as resources for each other during the Third Reich. Examining the KWIA from this perspective brings us a step closer to answering the questions at the heart of most recent scholarship concerning the biomedical community under the swastika: (1) How do we explain why the vast majority of German human geneticists and eugenicists were willing to work for the National Socialist state and, at the very least, legitimized its exterminationist racial policy; and (2) what accounts for at least some of Germany's most renowned medically trained professionals' involvement in forms of morally compromised science that wholly transcend the bounds of normal scientific practice? Although a complete answer to this question must await an examination of other German biological research centers, the present study suggests that during the Nazi period the symbiotic relationship between human genetics and politics served to radicalize both. The dynamic between the science of human heredity and Nazi politics changed the research practice of some of the biomedical sciences housed at the KWIA. It also simultaneously made it easier for the Nazi state to carry out its barbaric racial program leading, finally, to the extermination of millions of so-called racial undesirables.

  1. 历届诺贝尔文学奖获得者之尤金·奥尼尔(Eugene O’Neill)

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>关于作者尤金·奥尼尔(Eugene O’Neill,1888~1953年)美国著名剧作家,表现主义文学的代表作家,美国民族戏剧的奠基人。他4次获普利策奖,并于1936年获诺贝尔文学奖。他一生创作了45个剧本,题材广泛,风格多样。由于他的努力,美国的戏剧事业得以在20世纪20年代发展起来,成为美国文化领域中堪与小说、绘画、音乐作品相提并论的艺术形式,因而被公认为美国最重要的戏剧作家。

  2. Neural population with lateral inhibition of cortical columns based on the Hodgkin-Huxley model%基于Hodgkin-Huxley模型的皮层柱侧抑制神经元群

    Institute of Scientific and Technical Information of China (English)

    杜红伟; 王从庆

    2007-01-01

    HH(Hodgkin-Huxley)神经细胞模型一般被用于研究单个神经细胞的行为和特性,很少被用于构造人工神经系统.考虑神经细胞具有抑制性联结和兴奋性联结,将HH模型进行发展,提出了基于HH模型的神经元群,模拟大脑皮层柱的生理结构及侧抑制特性.分别将皮层柱内及皮层柱间的侧抑制机制应用于神经元群编码、解码,进行位置跟踪;改变解码策略,实现"胜者为王"功能.仿真实验表明了该神经元群模型的有效性,侧抑制特性的应用大大提高了位置跟踪精度、"胜者为王"效果.

  3. 广州市免费孕前检查医护人员专业认知与能力调查%Survey on professional knowledge and ability of medical personnel about the free preconception eugenic health check in Guangzhou

    Institute of Scientific and Technical Information of China (English)

    刘品佳; 曾晓琴; 肖青; 龚桂芳

    2015-01-01

    Objective To understand the level of professional knowledge and ability of medical person-nel responsible for free preconception eugenic health check in Guangzhou. Methods A total of 210 medical per-sonnel from 62 fixed service organizations responsible for free preconception eugenic health check were investi-gated by interview and questionnaire between September and December in 2013, with 208 valid questionnaires re-turned. Results Average correct rate of the knowledge surveyed on personnel about free preconception eugenic health check service policy and pre-pregnancy eugenic health was 85.33%and 94.07%. A total of 115 people (55.3%) regarded that the counseling service can meet the demand of the target population. Multivariate stepwise regression showed that profession at present (OR=1.317) and length of service (OR=1.368), self-reported training need (OR=9.595) and service ability (OR=1.471) were the main influencing factors which can meet the demand of the masses (P<0.001). Conclusion There has certain promotion space about the professional knowledge of medical personnel re-sponsible for free preconception eugenic health check in Guangzhou. In order to improve the social benefits of free preconception eugenic health check and achieve the purpose of primary prevention of birth defects, we should pay more attention to the comprehensive ability training, enhance awareness of the main public health service, and in-crease the favorable policy propaganda.%目的 了解广州市免费孕前优生健康检查服务医护人员专业认知及能力.方法 于2013年9~12月,从广州市62间开展免费孕前优生健康检查的定点服务机构内随机抽取210名医护人员,采用访谈及问卷进行调查,回收有效问卷208份.结果 被调查人员对免费孕前优生健康检查服务政策及孕前保健知识的平均答对率分别为85.33%和94.07%;认为目前咨询指导服务能满足目标人群需求者仅115名(55.3%);多元逐步回归分析显

  4. Saúde coletiva, nova genética e a eugenia de mercado Collective health, the new genetics, and market eugenics

    Directory of Open Access Journals (Sweden)

    Maria Helena Cabral de Almeida Cardoso

    2003-04-01

    Full Text Available Com os constantes avanços das técnicas de manipulação genética, o campo da saúde coletiva passou a lidar com a possibilidade de surgimento de uma ênfase genômica reducionista, para além das influências sócio-culturais. Nestas circunstâncias, o foco principal das intervenções em saúde coletiva voltar-se-ia para a abordagem genômica de "indivíduos" e suas "famílias" em detrimento de seu consagrado objeto - "populações". Assim, seria deslocada a prioridade central dos esforços (e recursos para reduzir o adoecimento em função das desigualdades sócio-econômicas. Ao lado dos benefícios dos conhecimentos genéticos, há a possibilidade de surgimento de novas práticas eugênicas a partir da disponibilização de testagens genéticas no mercado, com vistas à aquisição pelos indivíduos interessados, desde que estes sejam capazes de atuarem como respectivos agentes de consumo.Due to constant advances in genetic manipulation, the field of public health is faced with the possible emergence of a reductionist genomic emphasis, beyond socio-cultural influences. Under such circumstances, the main focus of public health interventions would shift towards a genomic approach to "individuals" and their "families", to the detriment of their consecrated object - "populations", thereby moving away from the current central priority of efforts (and resources aimed at reducing ill-health due to socioeconomic inequalities. Even admitting the benefits of genetic knowledge, a new eugenic practice may emerge from the availability of genetic tests on the marketplace aimed at individuals that can afford to consume them.

  5. Eugene O'Neill Interpreted from the Perspective of Tragedy%悲剧视界中的尤金·奥尼尔

    Institute of Scientific and Technical Information of China (English)

    赵亚珉; 夏玉玲

    2012-01-01

    Tragedy,usually viewed as the highest form of art,is composed of tragic consciousness and tragic spirit.Man,inevitably caught up in the complex conflicts between sense and sensibility,reality and ideal,survival and death,constantly keeps pursuing his own self-realization.Therefore,tragedy does not only lie in man's suffering and destruction but,more importantly,in his resisting attitude and his surpassing spirit when confronted with doomed misery and death.Honored as "father of modern American drama",Eugene O'Neill,composes a great number of tragedies to expose the social evils and inspire human life by their tragic spirit,and thus casts a long shadow on American literature and even the world literature.%悲剧素来被看作艺术的最高形式,由悲剧意识和悲剧精神两个要素构成。人在情感与理智、现实与理想、生存与死亡的复杂悲剧矛盾关系中,始终不懈地追求自我本质力量的实现。悲剧并非仅指生命的苦难与毁灭,更重要的是面对不可避免的苦难和死亡的来临时,人所持的敢于抗争的态度和勇于超越的精神。尤金.奥尼尔以悲剧进行创作、借悲剧阐释社会现实、用悲剧精神启迪人生,在美国文学乃至世界文学中影响深远。

  6. Arquivo de Antropologia Física do Museu Nacional: fontes para a história da eugenia no Brasil The National Museum's physical anthropology archive: sources on the history of eugenics in Brazil

    Directory of Open Access Journals (Sweden)

    Vanderlei Sebastião de Souza

    2009-09-01

    Full Text Available Apresenta um conjunto de fontes documentais que integram o Arquivo de Antropologia Física, de responsabilidade do Setor de Antropologia Biológica do Museu Nacional/UFRJ. O arquivo contém importante documentação sobre o Primeiro Congresso Brasileiro de Eugenia, realizado em 1929, no Rio de Janeiro, em comemoração ao centenário da Academia Nacional de Medicina. Além de originais dos trabalhos apresentados no evento - alguns inéditos -, constam também nesse arquivo documentos reunidos pela secretaria do Congresso, como convocações para a sua realização, ficha dos inscritos, correspondências, recortes de jornais e revistas com artigos sobre eugenia, bem como moções, relatórios e atas finais, constituindo acervo fundamental para a compreensão da história da eugenia no Brasil.The article presents a set of documental sources that are part of the physical anthropology archive administered by the National Museum's biological anthropology sector (UFRJ. The archive holds important documentation on the first Brazilian congress of eugenics, held in Rio de Janeiro in 1929, in celebration of the National Academy of Medicine centennial. In addition to the originals of papers presented at the event (some unpublished, the archive also contains a series of documents compiled by the congress organizers, including announcements of the event, attendee registrations, correspondence, newspaper and magazine clippings of articles on eugenics, as well as motions, reports, and final minutes, all of which makes this collection invaluable in understanding the history of eugenics in Brazil.

  7. Analysis on eugenics test results of 2 1 63 pregnant couple of Xingbin district in Laibin city%来宾市兴宾区2163对备孕夫妇优生检测结果分析

    Institute of Scientific and Technical Information of China (English)

    黄俊; 廖莉莉; 吴则崚; 张金莲; 张三萍; 陈世新

    2015-01-01

    目的:对备孕人群进行优生检查,找出孕前可能引起胎儿出生缺陷高危因素,为优生优育提供科学依据。方法对该辖区备孕2163对夫妇进行孕前优生检测,评估怀孕风险。结果检出具有怀孕风险人数1547例,检出阳性率35.76%(1547/4326),其中男性阳性率26.81%(580/2163),女性阳性率44.71%(967/2163),女性阳性率明显高于男性。结论怀孕前进行优生检查,可尽早发现怀孕风险,以便及时采取相应预防措施,对预防出生缺陷有重要意义。%Objective To conduct eugenics inspections for preparing pregnant couples,to find out risk factors causing fetal birth defects,to provide the scientific basis of eugenic and superior nurture.Methods A total of 2 1 63 preparing pregnant couples were conducted eugenics detection before childbirth to assess pregnant risk.Results A total of 1 547 cases were checked out with preg-nancy risk with the positive rate as 35.76%(1 547/4 326).Among them,the positive rate of male was 26.81% (580/2 1 63).the positive rate of women was 44.71% (967/2 1 63).Women positive rate was significantly higher than the male.Conclusion The eu-genics detection before pregnant could found risk of pregnancy as soon as possible,in order to take corresponding preventive meas-ures in time,has important significance for prevention of birth defects.

  8. Stabilization of garnet in metamorphosed altered turbidites near the St. Eugene lead-zinc deposit, southeastern British Columbia: Equilibrium and kinetic controls

    Science.gov (United States)

    Pattison, David R. M.; Seitz, JennaLee D.

    2012-03-01

    The St. Eugene lead-zinc deposit, near Moyie, southeastern British Columbia, is a Mesoproterozoic vein deposit hosted by metaturbidites of the 1.5-1.4 Ga Belt-Purcell Supergroup. The regional metamorphic grade of the rocks is biotite zone, with the age of metamorphism being Mesoproterozoic (ca. 1.35 Ga). The vein system is enveloped by a metamorphosed alteration zone of increasing intensity as the vein is approached. Thin argillaceous tops of turbidite beds away from the vein are garnet-free, whereas those in the inner alteration zone are garnet-bearing. Compared to rocks away from the vein, those near the vein are enriched in Fe, Mn, Pb and Zn, with proportional reduction in other compositional parameters. Thermodynamic modeling of three rocks across the alteration gradient predicts increasing stabilization of garnet with increasing degree of alteration. Predicted and observed modes of garnet in the samples are in close agreement. In the most altered rock, the garnet-in line is displaced down-temperature by ~ 100 °C relative to the least altered rock. Approximately 2/3 of the garnet stabilization is accounted for by increase in Mn content and the rest by increase in Fe/(Fe + Mg). Kinetic factors played a role in the development of the mineral assemblages, including metastable persistence of zoisite, and disequilibrium (overstepped) initial growth of garnet. Estimates of peak pressure-temperature conditions from mineral assemblage constraints and from compositional isopleths are complicated by the kinetic effects but yield similar results: 490-510 °C and 3.6-4.0 kbar. The pressure-temperature estimates imply an average linear geothermal gradient of ~ 35 °C/km, broadly consistent with burial metamorphism in the Belt-Purcell extensional basin. However, the estimated pressure, equivalent to a depth of 13-15 km, is greater than the estimated ~ 8 km (~ 2.2 kbar) of stratigraphic overburden at the time of metamorphism. The results of this study support the idea that

  9. Educar para regenerar e selecionar. Convergências entre os ideários eugênico e educacional no Brasil Educating to regenerate and select. Convergences between the eugenic and educational principles in Brazil

    Directory of Open Access Journals (Sweden)

    Regina Cândida Ellero Gualtieri

    2008-12-01

    Full Text Available O artigo discute algumas convergências entre o pensamento eugenista e o pensamento pedagógico brasileiro do início do século 20. O ideário eugênico incluía a convicção de que diferenças individuais eram biologicamente determinadas e isso foi considerado um avanço por educadores como Fernando de Azevedo (1894-1974, membro da Sociedade Eugênica de São Paulo (1918-1919, pois, nessa perspectiva, todo indivíduo teria o direito a ser educado e regenerado até onde suas “aptidões permitissem”. A educação deixaria de ser privilégio de condição social para constituir “direito biológico”, propiciando a seleção “dos mais bem-sucedidos” e a construção da “hierarquia das capacidades”. Esse entendimento evoca o que Michel Foucault denominou “biopoder” – um modo de tratar os fenômenos coletivos como problema biológico e político – para cuidar do “homem-espécie” e não apenas do indivíduo, garantindo normas capazes de distribuir os indivíduos em um “domínio de valor e utilidade” e instalando mecanismos para qualificar e hierarquizar populações. Muitas dessas questões permanecem no debate educacional contemporâneo. Palavras-chave: Eugenia. Biopoder. Seleção. Regeneração. Educação eugênica. This article discusses convergences between eugenics and the Brazilian pedagogic educational principles in the beginning of the 20th century. The eugenical ideal stated that individual differences were biologically determined and this conception was considered a progressive idea by educators like Fernando de Azevedo (1894-1974 who belonged to the Eugenics Society of Sao Paulo (1918-1919. In this perspective, every individual was entitled to being educated as well as regenerated according to his abilities and this meant that education wouldn’t be treated as a privilege of the social high classes anymore. Such understanding evokes what Michel Foucault named “biopower” – a way to control an

  10. Inovação e concorrência em serviços de informação acadêmica: de Eugene Garfield ao google scholarInovation and competition in scholar information services: from Eugene Garfield to google scholar

    Directory of Open Access Journals (Sweden)

    Eduardo Beira

    2010-01-01

    Full Text Available Discutem-se os processos de inovação envolvidos, desde a luta empreendedora de Eugene Garfield e do ISI Institute for Scientific Information nos últimos 40 anos até meados dos anos 90, e as mudanças que a entrada do Google Scholar tem provocado com o seu modelo de negócio baseado num mecanismo de inovação disruptiva. Os processos de inovação envolvidos são discutidos com base em modelos sociais de inovação empresarial. Apresenta‑se evidência empírica comparando resultados de procuras no ISI/WoS e no Google Scholar, que mostram o efeito de legacy da arquitectura de dados do ISI/WoS e que mostram que nenhum deles é perfeito. Ambos subestimam o número real de citações, e, para os casos apresentados, as citações únicas das duas origens são dominantes. Discute-se o significado das actuais “guerras das citações” como uma continuação das anteriores “guerras das ciências” e como uma continuação da permanente procura do significado e fundamento para o conhecimento científico e para a actividade académica. Argumentamos que o modelo aberto e dinâmico do Google Scholar é muito mais coerente com a realidade, e permite uma visão mais completa dos múltiplos processos envolvidos na actividade científica e académica – algo que tem importantes implicações sobre as políticas para o sector.During last forty years scholarly information services developed from near non existence to a significant business with deep implications in the management of science and academic institutions. We discuss the innovative business struggle of Eugene Garfield and ISI Institute for Scientific Information until mid 90's, and the changes after the Google Scholar entered the market with an highly disruptive business model. The processes are discussed in the context of social frameworks for business innovation. Changes in the market during last decade are analysed and the implications for future are explored. Empirical data is

  11. Laenuraha ja vabadus / Eugen Veges

    Index Scriptorium Estoniae

    Veges, Eugen, 1955-

    2008-01-01

    Ilmunud ka: Lääne Elu 10. jaan. lk. 2, Kuulutaja 11. jaan. lk. 4, Koit 12. jaan. lk. 6, Võrumaa Teataja 15. jaan. lk. 2, Valgamaalane, Tartu Ekspress 17. jaan. lk. 2,6. Autori sõnul võib kollektiivne tarbimise vähenemine olla üpris mõjus hoob põhjendamatu kiirusega hindade kasvu peatamiseks

  12. Kaks head uudisasja / Eugen Veges

    Index Scriptorium Estoniae

    Veges, Eugen, 1955-

    2008-01-01

    Ilmunud ka:: Sakala 16. juuli lk. 2, Oma Saar 29. juuli lk. 5. . Autor selgitab sisemajanduse kogutoodangu ning elanike ostujõu mõistete erinevust ja põhjendab, miks neid kahte näitajat ei saa omavahel võrrelda, samuti kritiseerib poliitikute suhtumist SKP-sse kui üksnes kvantitatiivsesse näitajasse

  13. Demonstration Assessment of Light Emitting Diode (LED) Residential Downlights and Undercabinet Lights in the Lane County Tour of Homes, Eugene, Oregon

    Energy Technology Data Exchange (ETDEWEB)

    Ton, My K.; Richman, Eric E.; Gilbride, Theresa L.

    2008-11-10

    In August 2008 the Pacific Northwest National Laboratory (PNNL) conducted a light emitting diode (LED) residential lighting demonstration project for the U.S. Department of Energy (DOE), Office of Building Technologies, as part of DOE’s Solid State Lighting (SSL) Technology Demonstration Gateway Program. Two lighting technologies, an LED replacement for downlight lamps (bulbs) and an LED undercabinet lighting fixture, were tested in the demonstration which was conducted in two homes built for the 2008 Tour of Homes in Eugene, Oregon. The homes were built by the Lane County Home Builders Association (HBA), and Future B Homes. The Energy Trust of Oregon (ETO) also participated in the demonstration project. The LED downlight product, the LR6, made by Cree LED Lighting Solutions acts as a screw-in replacement for incandescent and halogen bulbs in recessed can downlights. The second product tested is Phillips/Color Kinetics’ eW® Profile Powercore undercabinet fixture designed to mount under kitchen cabinets to illuminate the countertop and backsplash surfaces. Quantitative and qualitative measurements of light performance and electrical power usage were taken at each site before and after initially installed halogen and incandescent lamps were replaced with the LED products. Energy savings and simple paybacks were also calculated and builders who toured the homes were surveyed for their responses to the LED products. The LED downlight product drew 12 Watts of power, cutting energy use by 82% compared to the 65W incandescent lamp and by 84% compared to the 75W halogen lamp. The LED undercabinet fixture drew 10 watts, cutting energy use by 83% to 90% compared to the halogen product, which was tested at two power settings: a low power 60W setting and a high power 105W setting. The LED downlight consistently provided more light than the halogen and incandescent lamps in horizontal measurements at counter height and floor level. It also outperformed in vertical

  14. 从尤金·奈达的翻译理论鉴赏许渊冲的译诗名句%An Analytical Appreciation of Xu Yuanchong's Tranlation Rhesis from the Perspective of Eugene Nida's Translation Theory

    Institute of Scientific and Technical Information of China (English)

    牛云平; 王亚南

    2014-01-01

    The paper briefly introduces Eugene Nida's translation theories and gives an analytical appreci-ation of Xu Yuanchong's English translation of“不爱红妆爱武装”from the aspects of diction ,rhetorical device ,style and culture .As is demonstrated ,Nida's translation theory and Xu's translation principles are very similar to each other .%简要介绍了尤金·奈达的翻译理论,并从选词、修辞、风格和文化四个角度分别鉴赏了许渊冲对“不爱红妆爱武装”的英译。通过具体的分析和鉴赏,可以看出,奈达的翻译理论和中国翻译大家许渊冲的翻译原则如出一辙、遥相呼应。

  15. The birth of schizophrenia or a very modern Bleuler: a close reading of Eugen Bleuler's 'Die Prognose der Dementia praecox' and a re-consideration of his contribution to psychiatry.

    Science.gov (United States)

    Maatz, Anke; Hoff, Paul

    2014-12-01

    After Eugen Bleuler introduced 'schizophrenia' in 1908, the term was hotly debated but eventually led to the abandonment of Kraepelin's previous term 'dementia praecox'. Bleuler's contribution has subsequently been interpreted in two main ways. One tradition holds that Bleuler merely renamed 'dementia praecox' while conceptually continuing the Kraepelinian tradition. The other, focusing on Bleuler's characterization of 'dementia praecox' in terms of specific psychological alterations, accredits him with a genuine re-conceptualization. Based on a close reading of 'Die Prognose der Dementia praecox', the paper in which Bleuler first mentioned 'schizophrenia', we suggest a further interpretation of Bleuler's contribution and argue that the main motive for his re-conceptualization is to be found in his rejection of Kraepelinian nosology. © The Author(s) 2014.

  16. The Malady of UNESCO's Archive

    Directory of Open Access Journals (Sweden)

    Peter Jackson

    2014-10-01

    Full Text Available This paper offers a critical examination of UNESCO's cultural heritage conven-tions with special regard to the declared transhumanism of the organization's first director-general, Sir Julian Huxley. While Huxley's advocation of eugenics is a well-established fact, this part of his intellectual heritage is usually not considered overtly aligned to his ideas about cultural preservation. On closer consideration, however, improvement and preservation (both cultural and biological turn out to be closely associated concerns in the field of Huxley's intellectual vision.

  17. 再论“多余人”--《叶甫盖尼·奥涅金》形象分析%“The irrelevant”---character analysis of Eugene Oneguine

    Institute of Scientific and Technical Information of China (English)

    欧炫佑

    2015-01-01

    Eugene Oneguine is one of immortal characters in Russian literature ,and the first “the irrelevant” char-acter in global literature .From then on ,similar characters have kept springing up in the world literature .However , the explorations in the past have been focused on the historical factors and background information ,thus neglecting the complexity of this character .Probably Eugene Oneguine ,the irrelevant,is supposed to be analyzed in an essen-tial and perpetual angle of humanity ,and put with Tatyana under the spotlight of comparison with an attempt to i-dentify its common features and nature at core .This is supposed to help us with discovering more profound under-standing and interpretations of “the irrelevant”.%叶甫盖尼·奥涅金是俄罗斯文学中的不朽形象,也是世界文学当中第一个“多余人”形象。自此,世界文学中逐渐出现了很多“多余人”和“类多余人”。过往对多余人的研究大部分过分强调其历史背景因素,这样的角度其实是缩小了这个形象的广泛性。试图从人性这个本质而永恒的角度去分析“多余人”形象,并把奥涅金和达吉雅娜放在一面镜子的两面进行审视,能帮助挖掘出这个形象的核心共性和真实内涵,对“多余人”形象进行更为深入的理解。

  18. 从《榆树下的欲望》看尤金·奥尼尔对人性的解读%Eugene O'Neill's interpretation of humans's nature:under the analysis of Desire Under the Elms

    Institute of Scientific and Technical Information of China (English)

    宁琳

    2011-01-01

    Desire Under the Elms is one of Eugene O'Neill's classical works.This article is going to show Eugene O'Neill's theory of tragedy—the tragedy is not made only by the outer world,but the human being's own shortcomings of tragedy.From this play we can see Eugene O'Neill's severe desire to the human's sincerity,and show his hostility and disappointment to the greed of human being.It is warning people that—do not let your nature be twisted by the desire for the money and property in the mean world.%通过对奥尼尔经典作品之一《榆树下的欲望》中主要人物的分析,展现出奥尼尔的悲剧论,以及他对贪婪人性的敌对、失望和对唤起人性真实的渴望。他认为人的悲剧是由多方面因素造成的,而自身性格的弱点和缺陷是不可忽视的重要因素。故事试图向人们揭示出,当金钱成为衡量一切的标准时,人的自然情感是怎样被压抑和扭曲的。

  19. Analysis of the general risk factors in pre-pregnancy eugenics inspection%孕前优生健康检查一般风险因素分析

    Institute of Scientific and Technical Information of China (English)

    邹超英; 谢芳; 熊桂荣; 周立晓; 郭昭鹏; 刘鲁峰; 谢辉艳; 李鸿敏

    2015-01-01

    目的:探讨计划妊娠的夫妇孕前风险因素,降低导致出生缺陷等不良妊娠结局的风险因素。方法收集深圳市罗湖区2013年9429名计划妊娠夫妇的免费孕前优生检查资料,对待孕夫妇存在的孕前风险因素进行分析。结果女性孕前风险因素排在前五位的是:生殖系统检查异常(60.51%)、甲状腺功能异常(23.56%)、环境风险因素(19.83%)、低体重(18.53%)、不良妊娠史(13.58%)。男性风险因素排在前五位的是:超重和肥胖(41.94%);生殖系统检查异常(30.39%)、吸烟(28.76%)、环境风险因素(20.66%)、心理风险因素(19.14%)。结论应针对孕前风险因素对已婚育龄夫妇进行规范化的孕前优生指导,加强一级预防,减少出生缺陷儿的发生率。%Objective Through the analysis of the result among planned pregnancy couples with pre -pregnancy eugenics inspection, reduce the risk factors associated with birth defects or other adverse pregnancy outcomes in planned pregnancy couples . Methods Collect and analyze the results of 9 429 people of planned pregnancy couples with free pre -pregnancy eugenics inspection during 2013, to find out the risk factors before pregnancy .Results According to the analysis of the inspection results , the top five risk of the factors before pregnancy of female are: abnormality of genital system ( 60.51 %) , thyroid dysfunction ( 23.56 %) , environment risk factor(19.83 %), low body weight(18.53 %), abnormal pregnancy (13.58 %).The top five risk of the factors male are:hypergravitation and obesity(41.94%), abnormality of genital system(30.39%), smoking(28.76%), environment risk factor(20.66 %), psychological hazard(19.14 %).Conclusion Strengthen pre -pregnancy eugenics inspection of child -bearing age couples , standardize pre -pregnancy guidance and effective primary prevention have important significance for reducing the incidence of

  20. 影响中山市孕前优生健康检查中健康教育质量的因素调查与分析%Factors Survey and Analysis of Affecting Zhongshan City Pregnancy Eugenics Health Education Quality in the Health Examination

    Institute of Scientific and Technical Information of China (English)

    吴瑞霞

    2016-01-01

    Objective:To study the influence factors of Zhongshan City pregnancy eugenics health education quality in the health examination.Method:A total of 1000 cases of registered population and transient population family planning couple were selected from Zhongshan City,referred to“about undergo pre-baby eugenics health education for pregnant couples questionnaire”,pre-baby eugenics health education quality influencing factors in health examination were investigated.Result:986 valid questionnaires were totally recovered, the recovery rate was 98.60%(986/1000).Health education in pregnancy health inspection object were mainly in 20-40 years old,professional,high school or above,eugenics health education existing way of promotion werelectures,Internet,television and newspapers,understand and accept to eugenics health education project consciously or passive consulting service check,to gain higher expectation eugenics health knowledge,attitude toward the experience in the family planning personnel,professional and obtained satisfactory evaluation. Conclusion:Through health knowledge lecture,personalized health guidance,video health education,health education publicity column,outpatient health counseling and follow-up education helps to strengthen the family planning couple's concept of eugenic and superior nurture,reduce the risk of birth defects.%目的:探讨中山市孕前优生健康检查中健康教育质量的影响因素。方法:选取中山市户籍与流动人口计划生育夫妇共1000对,参照《关于接受孕前优生健康教育待孕夫妇的调查问卷》调查孕前优生健康检查中健康教育质量的影响因素。结果:共回收986份有效问卷调查表,回收率98.60%(986/1000)。孕前健康检查中健康教育对象主要以20~40岁,有职业,高中及以上学历为主,对优生健康教育现有的宣传推广方式(讲座、网络、电视与报纸)了解并接受,对优生健康教育服务项目自觉

  1. The Perspectives of Nobel Prize Studies Made by the Information Scientist Eugene Garfield%情报学家尤金·加菲尔德关注诺贝尔奖的视角

    Institute of Scientific and Technical Information of China (English)

    李艳霞

    2011-01-01

    本文考察了美国著名情报学家尤金·加菲尔德研究诺贝尔奖的视角,通过研究分析加菲尔德个人网页中关于诺贝尔奖的51篇原文,我们对这位情报学家研究诺贝尔奖的视角有了比较深入的了解。加菲尔德研究引文分析能否预测诺贝尔奖,他们是否都写过引文杰作,获奖项目是否是所在领域的研究前沿,最高被引频次、获得诺贝尔奖和科学承认之间的关系,职业合作伙伴的重要性,关注日本的科学研究环境,运用引文分析确定是否属于早期发现等七个方面来发表自己独特的见解。%This article explored the perspectives of Nobel Prize studies made by the famous American information scientist Eugene Garfield.Researching and analysising all the 51 original texts about the Nobel Prize studies come from Garfield personal pages,we know b

  2. Podstawowy fenomen śmierci według Eugena Finka. Między 'polis' a 'kosmos' (BASIC PHENOMENON OF DEATH ACCORDING TO EUGEN FINK. BETWEEN POLIS AND KOSMOS

    Directory of Open Access Journals (Sweden)

    Andrea Gilardoni

    2007-06-01

    Full Text Available In the first part of the paper the author presents Eugen Fink's analysis of the phenomenon of death, using meditation (considered as a kind of meta-phenomenology and the reduction method. He investigates the problem of an appropriate phenomenological method (concerning the possibility of making an intersubjective reduction and the problem of the phenomenon in question - it is initially very puzzling how a description of death could ever be possible, as it constitutes a limit situation and doesn't belong to the realm of life. Trying to preserve the intersubjectivity of experience Fink distinguishes two perspectives: my own death and somebody else's death, and makes the corresponding distinction between existence and coexistence. In the second part of the paper death is being considered as entangled in other phenomena of being: work (men's attitude to things and reign (which is an interpersonal relation. Finally, these two phenomena are described in different models of associations with phenomena of power, politics and death.

  3. Late Abortion: A Comprehensive Review

    Directory of Open Access Journals (Sweden)

    Sheng Chiang

    2005-12-01

    Full Text Available Late termination of pregnancy (LTOP is defined as an abortion carried out beyond 24 gestational weeks, when the fetus has arguably attained viability. In Taiwan, the current abortion law, bearing a eugenic title, allows LTOP on certain medical grounds. However, the fetal and maternal conditions that constitute medical grounds are not clarified and remain legally untested. Professional debate on the abortion issue is also lacking in academia in Taiwan, despite societal concerns. With the advent of technology to detect fetal abnormalities, obstetricians are now confronted more frequently with acute dilemmas regarding LTOP. Quite often, they sail in an uncharted sea with no clinical guidelines from their professional societies or affiliated hospitals. Recently, LTOP at 35 gestational weeks for a fetus with Down syndrome, complicated with polyhydramnios and tetralogy of Fallot, triggered media scrutiny and aroused much public attention. Although the clinical decision making for pregnancies with fetal abnormalities entails increasingly balanced information and consideration in terms of the medical, ethical, legal, psychologic, and societal aspects, society at large is unaware of the complexity and intertwined nature of various abortion issues, especially LTOP. Obstetricians are now in a vulnerable position in Taiwanese society, where litigations relevant to the practice of early abortions are not rare. Therefore, a global and in-depth look into abortion issues from legal and ethical dimensions is indispensable for modern obstetric practice. This review considers the core issues in LTOP, including what conditions constitute a “serious” fetal abnormality to justify LTOP, the incidence of LTOP, legislation regarding LTOP in Western countries, and recent research on ambivalent fetal pain. It will also present procedures, some under the auspices of the ethical committee of a Presbyterian hospital in Taiwan, for clinical decision making, particularly

  4. 孕前优生健康检查中地中海贫血筛查的技术方案%Technical solutions of thalassemia screening in pregestational eugenical health examination

    Institute of Scientific and Technical Information of China (English)

    倪少义; 吴翔; 蔡佩微; 吴如茂; 林细佳; 陈育娟; 王榕生; 吴献章; 陆书敬

    2014-01-01

    目的:探讨孕前优生健康检查中新婚待育夫妇地中海贫血筛查在出生缺陷干预应用中的意义,为预防和减少地贫病患儿的出生提供依据。方法双方均为潮汕平原地区户籍的孕前优生健康检查对象12092例,所有样品均采用MCV法进行初筛,以静脉血平均红细胞体积(MCV≤80fL)作为诊断地贫的阳性参考指标。再应用Gap-PCR和反向点杂交技术(RDB-PCR)对部分样品进行α地贫基因和β地贫基因定型。结果在1679例(MCV≤80fL)血标本中检出7种α-地贫等位基因(染色体)942例,检出9种β-地贫等位基因(染色体)482例,计算上10413例MCV阴性α-地贫基因推算数205例和10413例MCV阴性-β地贫基因推算数46例,则潮汕平原地区人群α-基因携带率为9.49%(1147/12092),β-基因携带率为4.37%(528/12092)。结论新婚夫妇地中海贫血系统筛查及基因诊断能及时发现各类地贫异常患者,对预防出生缺陷有着重要意义。%Objective To investigate the significance of thalassemia screening in newly married couples preparing to have children in preventing birth defects in pregestational eugenical health examination and provide reference for preventing and reducing the birth of children with thalassemia. Methods Both parties were 12 092 registered permanent residents receiving pregestational eugenical health examination in Chaozhou-Shantou flat area and all the samples were screened primarily using the MCV method. Mean corpuscular volume (MCV≤80) of venous blood served as the positive reference indicator of thalassemia diagnosis. Then Gap-PCR and reverse dot blot technique (RDB-PCR) were used to conductα-thalassemia gene andβ-thalassemia gene genotyping on some samples. Results Of 1679 blood specimens (MCV ≤ 80), 942 cases of 7 types of α-thalassemia allele (chromosome) and 482 cases of 9 types of β-thalassemia allele (chromosome) were detected, and counting 10

  5. L’influence de l’eugénisme galtonien dans la pensée de Joseph Alois Schumpeter The Influence of Eugenics in Joseph Alois Schumpeter’s theory

    Directory of Open Access Journals (Sweden)

    Fabrice Dannequin

    2012-11-01

    Full Text Available Dans sa théorie du capitalisme, Joseph Alois Schumpeter mobilise l’eugénique, notamment les travaux de Francis Galton. Ce dernier a élaboré une vision hiérarchisée et héréditariste des hommes. Il l’a notamment appliquée à la question de la pauvreté en reprenant les données empiriques de Charles Booth. Schumpeter reprend ces éléments comme socle de l’explication de l’inégalité sociale et dans la construction de sa théorie de l’entrepreneuriat. Les entrepreneurs constituent une élite se démarquant de la masse, en engendrant l’évolution de la société du fait de leurs talents innés. Le capitalisme ne peut déboucher sur la disparition totale de la pauvreté. En effet, les individus biologiquement moins « dotés » sont condamnés à rester au bas de l’échelle sociale.In his theory about capitalism, Joseph Alois Schumpeter uses eugenics, and especially Francis Galton’s work. The former has conceived a hierarchized vision of society, and a hereditary vision of the transmission of talents. He notably applied it to the question of poverty by using Charles Booth’s empirical data. Schumpeter uses these elements both as an explanation of social inequality and as a basis of his theory of entrepreneurship. To him, the entrepreneurs are an elite standing out against the masses since they have the innate talents to generate evolution. Capitalism cannot totally eradicate poverty. Indeed, the least biologically gifted are bound to remain at the bottom of the social ladder.

  6. 慈父还是恶魔--试析尤金·奥尼尔剧作中的上帝意象%Loving Father or Devil:Image of God in Eugene O’Neill’s Works

    Institute of Scientific and Technical Information of China (English)

    杨庆龙

    2014-01-01

    尤金·奥尼尔剧作中的上帝已经不是狭义的基督教意义上的上帝了。它是指一种生活背后的神秘的终极力量。这个“上帝”的概念是模糊的、不确定的,在奥尼尔不同的作品中因主人公所处情势的不同而具有不同的意象。有时它是指资本主义工业化阶段使人异化的资本主义社会机器;有时它是指清教文化环境下奉行聚财和禁欲的清教上帝,这个清教上帝实质上是清教徒们主观理解和建构的上帝,是清教伦理的拟人化与上帝化;有时它又指的是神秘的大自然。%The God in Eugene O’Neill’s works is not the Christian god in narrow sense,but a mysterious ultimate force hidden behind life.The image of God,which is vague and indefinite,varies from one situation to another according to the real circumstances of O ’Neill ’s different protagonists.Sometimes the God is the alienating capitalism social machine in the capitalist industrialization stage;occasionally it becomes the Puritan God under the background of the Puritan culture advocating accumulating money and abstinence,which is essentially the god comprehended and constructed subjectively by the Puritans and is the personalized and sanctified Puritan ethics;at times it turns to be the mysterious nature.

  7. 紫杉醇联合奈达铂在老年食管癌的疗效分析%Analysis Curative Effect of Taxol Combine With Eugene Nida in Senium Patients With Esophagus Cancer

    Institute of Scientific and Technical Information of China (English)

    陈文玲

    2016-01-01

    目的:探究紫杉醇联合奈达铂治疗老年食管癌的临床疗效。方法根据治疗方案不同将66例老年食管癌患者分为A组(36例)和B组(30例),分别给予紫杉醇联合奈达铂和紫杉醇联合顺铂,比较两组近期疗效、毒副反应及1、2年内生存率。结果 A组毒副反应发生率低于B组,1、2年生存率均高于B组,差异有统计学意义(P<0.05)。结论对于老年晚期食管癌,多采用紫杉醇联合奈达铂治疗,近期疗效和耐受性均较高,可提高患者生存率。%Objective Analysis curative effect of taxol combine with eugene nida in senium patients with esophagus cancer.Methods 66 cases of elderly patients with esophageal cancer, which were divided into group A (36 cases) and group B (30 cases), were given nida, paclitaxel plus cisplatin and paclitaxel combined cisplatin, compared two groups in the near future curative effect, adverse reaction and 1, 2 year survival rate.Results The incidence of adverse reaction of group A is lower than group B, 1, 2 year survival rates were higher than group B, the more significant difference (P<0.05).Conclusion The elderly advanced esophageal cancer, with paclitaxel plus platinum chemotherapy treatment pattern, the recent high efficacy and tolerability, can improve patients survival rate.

  8. 尤金·奈达与彼得·纽马克翻译理论对比研究%The Contrastive Study on the Translation Theories between Eugene A · Nida and Peter Newmark

    Institute of Scientific and Technical Information of China (English)

    胡爱萍

    2014-01-01

    尤金·奈达和彼得·纽马克是现代西方翻译学界的突出代表,是著名的语言学家和杰出的翻译家。他们的译学理论都建立在语言学基础之上,有很多相似之处,却又各具特色。奈达毕生从事《圣经》的翻译工作,在此基础上提出了著名的“动态对等”或“功能对等”翻译理论。他非常重视读者的反应和译作的沟通作用。纽马克一生从事教学工作,他注重译文的准确性及质量,提出了著名的“语义翻译法”、“交际翻译法”及关联翻译理论。%Eugene A · Nida and Peter Newmark are the prominent representa- tives in the modern western translation circle. They were famous and outstand-ing linguistics 、translation theorists and translators. many significant similarities and distinctive features. though both of them based their translating theories on the linguistics, Nida made a great contribution to the translation of the Bible, from which he put forward the popular “dynamic equivalence” or “functional equivalence”. He paid more at-tention to the response of the readers and the communicating function of the translation. But Peter Newmark devoted himself to the teaching career in some of the universities. He emphasized the accuracy and the high quality of the translation. He proposed the famous “semantic translation” and“com-municative translation”.

  9. Investigation of Eugenics Knowledge, Attitude and Practice of the Candidates for Pregnancy in Changzhou%常州市待孕妇女优生优育知识、态度及行为调查

    Institute of Scientific and Technical Information of China (English)

    汪晓东; 张秀敏; 刘妍妤; 董兰; 吴方园; 赵璐; 刘冰; 刘莹圆; 刘红箭

    2016-01-01

    Objective: To realize the eugenics knowledge, attitude and practice of the candidates for pregnancy in Changzhou, provide sug-gestions which could reduce the incidence of birth defects for relevant departments to make effective strategies.Methods:From January to June in 2014, the questionnaire surveys were conducted among the candidates for pregnancy who volunteered for the free pre -pregnancy physical exami-nations in Changzhou.Results: Specific knowledge awareness rate was 81.4%-96.3%, the awareness rate of all the knowledge was 56.5%. Among the attitudes of eugenics, The awareness rate of each specific service project that prevent birth defects was 95.6%-98.8%, and 89.6%of the candidates for pregnancy thought that the specific service projects to prevent birth defects were all very important.4.2% of the candidates for pregnancy smoked, 63.4% of them suffered from passive smoking, 18.6% drank, and only 70.4% of them participated in the premarital physical examination which others hadn’ t realize it yet.Conclusion:The knowledge on how to bear and rear healthy children was well grasped by the candidates for pregnancy in Changzhou, but without a comprehensive.Many of them had passive attitude on bearing and rearing health chil-dren, and most people had harmful behaviors.Carrying out health education actively, popularizing knowledge of Eugenics, and using the health belief model to change the danger of harmful behaviors can play an important role in the prevention of birth defect .%目的:了解常州市待孕妇女优生优育知识、态度、行为及其影响因素,为相关部门制定干预策略,降低新生儿出生缺陷发生率提供依据。方法:以2014年1-6月常州市自愿参加免费孕前优生健康检查的待孕妇女为研究对象,采用自填式问卷调查法进行调查。结果:优生优育各知识点回答正确率为81.4%-96.3%,各知识点全部回答正确率为56.5%。在对待优生优育

  10. Fifty years after the Nuremberg Nazi Doctors' Trial: reviewing how the laws of the Third Reich applied to individuals with oral clefts.

    Science.gov (United States)

    Wyszynski, D F

    1998-02-01

    The Nazi Doctors' Trial, held in the city of Nuremberg 50 years ago, is a landmark in the history of medicine and science. For the first time, the horrors inflicted by a group of German scientists on innocent victims became widely known. Most of the defendants received sentences that ranged from relatively short imprisonment to death. The Trial also provided elements to develop standards for permissible medical experimentation, known as the Nuremberg Code. The atrocities judged in the Nazi Doctors' Trial, however, were not isolated. They were part of an overall eugenic system that encouraged euthanasia, compulsory sterilization, and selective marriages based on "genetic health" and "racial hygiene." Individuals with oral clefts were considered subject to these laws and suffered their consequences. This paper describes the main features of the Trial, reviews the state of knowledge on oral clefts in the 1930s and 1940s, presents how the laws of the Third Reich impacted the lives of individuals with oral clefts, and speculates on the implications of past and present eugenic policies in the future of humankind.

  11. 学术论文摘要汉英翻译的理念与技巧——以尤金·奈达的翻译理论为中心%Theory and Skill Application to Abstract Chinese-English Translation——Centering on Eugene Nida's Theory

    Institute of Scientific and Technical Information of China (English)

    张东秋

    2010-01-01

    学术论文汉语摘要英译是汉英翻译实践的一个特殊组成部分.将尤金奈达(EugeneNida)提出的翻译理论作为一种理念应用到摘要翻译中,以译文读者获得与原文读者相同或对等的信息为翻译目的,以篇章为翻译单位,可以使汉语摘要的英译实践得以顺利地进行.

  12. Review of the Development of Cap Models for Geomaterials

    Directory of Open Access Journals (Sweden)

    Ivan S. Sandler

    2005-01-01

    Full Text Available The history of the development of Cap constitutive models is reviewed. The Cap family of models provides a powerful, yet adaptable way of representing many aspects of the dynamic stress-strain behavior of geological materials. These models have been extensively used for more than three decades to characterize the highly nonlinear behavior of soils, rocks and concrete, and are particularly well suited to the dynamic analysis arising in ground shock and seismic applications. The modern series of Cap Models is based on the adaptation of several earlier models, and was introduced in the early 1970’s as a result of university and corporate R&D technology development sponsored by the United States government. Dr. Eugene Sevin played a role in these activities during his tenure at the Defense Nuclear Agency. In this paper, the basic behavior of the early models is briefly discussed and compared, and the reasons for the introduction of Cap Models are outlined. Many adaptations of the Cap Model have been developed since the first model was introduced, and the salient features of some of these model extensions are also reviewed.

  13. 乌鲁木齐市部分地区农牧民和流动人口孕前优生结果分析%Analysis of the progestational eugenic result for agro-pastoralist and floating population in some areas of Urumqi

    Institute of Scientific and Technical Information of China (English)

    于江; 单湘婷; 王军; 谢金荣

    2014-01-01

    为了解计划怀孕夫妇双方一般情况及健康状况,开展孕前健康教育及优生咨询指导工作,降低出生缺陷发生风险,本文对606对符合生育政策、计划怀孕的农牧民和流动人口夫妇的孕前优生健康检查资料进行分析。实验结果表明:606对夫妇男方吸烟人数为381人,占男方受检总人数的62.87%,女方被动吸烟的人数为324人,占女方受检总人数的53.46%;存在不良饮食习惯人数男女共计152人;接触农药及新装修、油漆等人数男女共计228人;女方检出疾病中以生殖系统炎症发病率最高。参检人员由于文化程度低,语言沟通障碍等因素,造成孕前优生知识缺乏,优生意识淡漠。因此,应根据孕前优生健康检查结果,为计划怀孕夫妇提供综合性指导,从而有效减少出生缺陷发生,提高人口素质。%In order to understand the general state of health of the couples planning a pregnan-cy,carry out the progestational health education and eugenics counseling work and reduce the risk of birth defects,the data of progestational eugenic health examination for 606 pairs of cou-ples of agro-pastoralist and floating population meeting the policy on birth and planning a preg-nancy were analyzed. The number of smoking man is 381,accounting for 62.87%of the total number of male subjects;the number of passive smoking woman is 324,accounting for 53.46%of the total number of female subjects. A total of 152 men and women exist bad eating habits;a total of 228 men and women are exposed to pesticides and new fitment,paint and so on. The disease incidence of woman’s reproductive system phlegmonosis is the highest among the diseases detected. The results showed that the subjects are lack of progestational eugenic knowledge and apathy of eugenic sense due to the low educational level,language barriers and other factors. Therefore,we should provide comprehensive guidance for the couples

  14. Chinese Intellectual Elite's Theoretical Exploration of National Revival——Take The Eugenics Thoughts in the Republic of China Period Ascenter%中国知识精英对民族复兴的理论设想——以民国时期的优生学思潮为中心

    Institute of Scientific and Technical Information of China (English)

    刘波儿

    2012-01-01

    Since the late Qing,China faced strong pressure from the west.Under the threat of the death of nation,Yan Fu,as the representative of the Chineseused intellectual elite tried to introduce the knowledge of racial improvement by translating "TianYanLun "to the public.Chinese intellectual elite use this method to achieve the aim of "Nation Revival".With the start of the "eastward spread of Western Culture",Eugenics was viewed a modern Western science came into the vision of Chinese intellectual elite,thought it was a scientific entity can be attached to the application,and launched the discussion on how to revive national in the view of eugenics.The development of eugenics was a silhouette of the Chinese society's transformation in the external threat since 19 century.%晚清以来,中国面临西方世界的强大压力。在亡国亡种的威胁之下,以严复为代表的中国知识精英通过《天演论》等著译作将人种改良的知识介绍给大众,试图以"优种"的方式实现民族复兴。随着西学东渐的展开,优生学以现代西方科学的姿态进入中国知识精英的视野,被崇尚人种改良的知识精英们视作可依附应用的科学实体,并以优生学为视角展开了关于如何复兴民族的讨论。民国时期优生学思潮的发展是19世纪以来的中国社会在外部威胁之下转型的一个侧影。

  15. Designer Babies: Eugenics Repackaged or Consumer Options?

    Science.gov (United States)

    Baird, Stephen L.

    2007-01-01

    "Designer babies" is a term used by journalists and commentators--not by scientists--to describe several different reproductive technologies. These technologies have one thing in common: they give parents more control over what their offspring will be like. Designer babies are made possible by progress in three fields: (1) Advanced Reproductive…

  16. Alustama peab tulubaasi reformimisest / Eugen Veges

    Index Scriptorium Estoniae

    Veges, Eugen, 1955-

    2008-01-01

    Autori sõnul seostub haldusreform eelkõige omavalitsusüksuste arvu vähendamisega, seda, et reformimist vajab riigi haldusstruktuur tervikuna, teadvustatakse vähem. Ilmunud ka Meie Maa 7. okt. lk. 2; Lääne Elu 9. okt. lk. 2; Harju Ekspress 10. okt. lk. 6; Nädaline 14. okt. lk. 4; Põhjarannik 15. okt. lk. 2; Kuulutaja 17. okt. lk. 4; Võrumaa Teataja 21. okt. lk. 2

  17. Eugene Garfield-Glimpses of his writings

    Directory of Open Access Journals (Sweden)

    B K Sen

    2014-01-01

    Full Text Available Garfield in his active life used to contribute one article every week which appeared in Current Contents and some renowned journals. The articles thus contributed total around 1500. All these articles had finally appeared in the book called Essays of an Information Scientist in 15 volumes. The present article is based on the first five volumes of his Essays wherein the articles by Garfield have been initially grouped under broad subject headings like Awards, Bibliometric studies, Highly cited articles, etc and then a very brief description has been provided.

  18. Obituary: Ronald Eugene Pitts, 1949-2008

    Science.gov (United States)

    MacConnell, D. Jack

    2009-01-01

    Ronald Pitts, systems engineer in the Commanding Branch of the Space Telescope Science Institute and long-time Computer Sciences Corporation employee, died suddenly of a stroke on 4 May 2008 at his home in Laurel, Maryland. He was a dedicated scientist-engineer, husband, father, volunteer, and cherished friend to many. Ron was born on 19 January 1949 in Tucson, Arizona, and was raised, along with his sister Suzanne, on his parents' turkey farm outside Tucson. He picked up practical knowledge from his father, Vernon, and became a competent amateur electrician and plumber, skills he kept honed and used throughout his life. His mother, Ruth (Stephens), was a nurse and taught him compassion and patience and encouraged his inquisitive mind. Ron attended public schools and enrolled at the University of Arizona, graduating with a B. S. in Astronomy in 1971. Being from a family of modest means, he put himself through school working summers and part-time at a large copper mine south of town. Ron enrolled in the graduate astronomy program at the Ohio State University [OSU] in the fall of 1971 where he was a first-year fellowship student. During his second and third years, he was the Perkins Assistant, taking spectra for the very exacting but appreciative Philip Keenan who once remarked to another faculty member that Ron was the best observer he ever had. Later, in 1980, Ron was co-author with Keenan on "Revised MK Spectral Types for G, K, and M stars" and again in 1985 in a study of supergiants in open clusters. He met his future wife, Patricia Moore, also a graduate student in the department, and they were wed in 1973. Ron was also partially supported during his early OSU years by an NSF grant to Robert Wing, writing parts of Wing's photometric reduction code and observing on the program at Kitt Peak and Flagstaff in the summer of 1974. Wing remembers him as being very competent and pleasant to work with. Ron's thesis topic was "Oscillator Strengths for Neutral Iron and Silicon" under the direction of Gerald Newsom, and he was awarded the PhD in 1979. Newson recalls his facility with instrumentation, designing new circuitry to solve problems with the shock tube and ferreting out sources of systematic errors, and that it was enjoyable to work with him. In the fall of 1979, Ron went to Ball State University where he taught undergraduate astronomy classes for four years. In the summer of 1983, Ron left academia for the position of IUE Resident Astronomer with Computer Sciences Corporation [CSC] at the Goddard Space Flight Center where he joined a small contingent of other Ohio State graduates. For the next eleven years, he supported guest observers, implemented work-arounds as the IUE gyroscopes failed, improved calibrations, and had several proposals accepted to obtain spectra of spectrophotometric standards and to observe upper-main-sequence stars in the Pleiades, a Per, and NGC 2244, work that he did with Nancy Remage Evans. Ron worked diligently on the software to combine the best IUE calibration with ground-based data of the hot cluster stars and to fit the temperature and gravity. He also became interested in advanced technology for lunar remote telescopes and co-authored several studies with Peter Chen and others. After their children were of school age, Ron's wife Pat also worked for CSC/IUE for part of this period. In October 1994, Ron transferred to the Space Telescope Science Institute in Baltimore, Maryland, where he joined the science instrument commanding group under the direction of Vicki Balzano. His first task was helping to write the commanding software controlling the Space Telescope Imaging Spectrograph to be installed in HST in February 1997, and he became the in-house expert on the workings of this complex instrument, in particular on the details of the time-tag mode. In time, he became familiar with all the on-board instruments and oversaw the approval of the instrument commanding before the weekly HST command loads were distributed to the Goddard Space Flight Center for uploading to the telescope. In recent years, Ron participated in developing the onboard Javascript code for commanding the James Webb Space Telescope's Near-Infrared Spectrograph operations. He also helped write special commanding to support some activities to follow the final HST servicing mission. His "behind-the-scenes" contributions to IUE, HST, and JWST helped and will help astronomers around the world obtain their data. Ron seemed knowledgeable about almost any subject and could talk engagingly and at length on politics, economics, a variety of technical topics, the history of the early Church, and science fiction, among others. He was one of those people who always appeared to be smiling. He, Pat, and their daughter Marie enjoyed singing in the Central Maryland Chorale, and he served his church as an elder, Sunday-school teacher, and choir member. Ron sat on various church committees, set up and maintained the computers, and devoted many hours to the upkeep of the building. After Hurricane Katrina, he went on two mission trips with church members to help victims in Mississippi. Once again, his carpentry, electrical, and plumbing skills made him a valuable team member. Ron is survived by his wife, Pat, a cartographer at the National Oceanic and Atmospheric Administration, their son Mark, a graduate student in astronomy at the University of Hawaii, and their daughter Marie, a graduate student in biology at the University of Maryland.

  19. Riigieelarve eesmärgid / Eugen Veges

    Index Scriptorium Estoniae

    Veges, Eugen, 1955-

    2008-01-01

    Ilmunud ka: Põhjarannik, Meie Maa 3. sept. lk. 2, Severnoje Poberezhje 4. sept., lk. 2, Koit 4. sept. lk. 6, Harju Ekspress 5. sept. lk. 6, Võrumaa Teataja 6. sept. lk. 2, Vooremaa 11. sept., lk. 2, Lõunaleht 11. sept. lk. 4. Autori nägemus riigi eelarvepoliitika kujundamisest

  20. Riik ei ole inimeste hirmutamiseks / Eugen Veges

    Index Scriptorium Estoniae

    Veges, Eugen, 1955-

    2008-01-01

    Ilmunud ka: Vooremaa 12. aug., lk. 2, Severnoje Poberezhje 12. aug., lk. 2, Koit 12. aug., lk. 6, Valgamaalane 12. aug. lk. 2, Põhjarannik 14. aug. lk. 4, Sakala 15. aug. lk. 2, Järva Teataja 21. aug. lk. 2, Harju Ekspress 22. aug. lk. 4, Nädaline 26. aug., lk. 4, Võrumaa Teataja 26. aug. lk. 2, Lääne Elu 4. sept. lk. 2. Autori sõnul parandab rahvale kõrgeima võimu andmine liigselt pingestunud inimsuhteid, muudab väärastunud väärtushinnanguid ning ta on veendunud, et praegune valimisseadus ja erakonnaseadus nullivad igasuguse demokraatia

  1. Tabletitervishoid meid tervemaks ei tee / Eugen Veges

    Index Scriptorium Estoniae

    Veges, Eugen, 1955-

    2009-01-01

    Autori hinnangul tuleks tervishoiu rahastamise aluseid muuta. Maksumäära langetamine koos omavastutusega mõjuks hinna ja kvaliteedi suhtele, muudaks teenindaja ja teenindatava suhted mõistetavamaks ning patsiendile vastuvõetavamaks

  2. Mida hakata peale maamaksuga? / Eugen Veges

    Index Scriptorium Estoniae

    Veges, Eugen, 1955-

    2008-01-01

    Maamaksu kehtestamisest. Ilmunud ka Põhjarannik 17. aprill 2008, lk. 4, pealkiri kujul: kodudelt maamaksu kogumine tuleb lõpetada ; Harju Ekspress 25. aprill 2008, lk. 6, pealkiri kujul: maamaksust...

  3. Poliitiline monopol vajab reformimist / Eugen Veges

    Index Scriptorium Estoniae

    Veges, Eugen, 1955-

    2008-01-01

    Ilmunud ka: Sakala 24. sept. lk. 2, Nädaline 25. sept. lk. 4. Autori sõnul seisavad Eesti parteid rahvast kaugel, muuta tuleks erakondade rahastamissüsteemi ning rahvas peaks avalikult rääkima ühiskonnakorralduse puudustest

  4. Designer Babies: Eugenics Repackaged or Consumer Options?

    Science.gov (United States)

    Baird, Stephen L.

    2007-01-01

    "Designer babies" is a term used by journalists and commentators--not by scientists--to describe several different reproductive technologies. These technologies have one thing in common: they give parents more control over what their offspring will be like. Designer babies are made possible by progress in three fields: (1) Advanced…

  5. Riik ei ole inimeste hirmutamiseks / Eugen Veges

    Index Scriptorium Estoniae

    Veges, Eugen, 1955-

    2008-01-01

    Ilmunud ka: Vooremaa 12. aug., lk. 2, Severnoje Poberezhje 12. aug., lk. 2, Koit 12. aug., lk. 6, Valgamaalane 12. aug. lk. 2, Põhjarannik 14. aug. lk. 4, Sakala 15. aug. lk. 2, Järva Teataja 21. aug. lk. 2, Harju Ekspress 22. aug. lk. 4, Nädaline 26. aug., lk. 4, Võrumaa Teataja 26. aug. lk. 2, Lääne Elu 4. sept. lk. 2. Autori sõnul parandab rahvale kõrgeima võimu andmine liigselt pingestunud inimsuhteid, muudab väärastunud väärtushinnanguid ning ta on veendunud, et praegune valimisseadus ja erakonnaseadus nullivad igasuguse demokraatia

  6. Liberal eugenics and human nature. Against Habermas.

    Science.gov (United States)

    Fenton, Elizabeth

    2006-01-01

    In the course of developing his arguments against making genetic enhancements to one's children, Habermas assumes that a clear line can be drawn between the natural and the manufactured. But given the current state of medical science, this is precisely what we can no longer take for granted.

  7. Eugene O'Neill's Innovations in Tragedy:From the Per-spective of Triple World of Modern Tragedy%从现代悲剧三重世界看尤金·奥尼尔对悲剧艺术的创新

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

      本文采用任生名《西方现代悲剧论稿》中提出的阐释悲剧的新范式,探讨奥尼尔对于悲剧的创新。奥尼尔对于现代社会悲剧的创新在于他颠覆了传统悲剧的概念:悲剧的主人公从王子贵族演变成平常百姓;悲剧的起因从严肃的行为演变成日常琐事;悲剧的世界是“上帝已死”的世界。奥尼尔对于现代精神悲剧的创新在于对剧中人物内心世界的探索。在现代人本体悲剧这一层,奥尼尔用象征展示了现代人荒谬的处境。%This thesis is based on Ren Shengming's new model explaining the nature of tragedy. One of the most prominent con-tributions O'Neill has made to modern social tragedy is his use of common people as the protagonists of tragedy.Eugene O'Neill's exploration of human psyche is with unprecedented scope and depth in his plays. Eugene O'Neill contributes to modern onto-logical tragedy by revealing in his plays the absurd existence of human beings, pointing directly to anthropological ontology.

  8. Re-Viewing Peer Review

    Science.gov (United States)

    Flynn, Elizabeth A.

    2011-01-01

    In this article, the author revisits her essay, "Students as Readers of Their Classmates' Writing," by providing a review of the literature on peer review over the past three decades and comments on patterns she sees in waves of peer review research and theorizing. She describes her subsequent experience with peer review in her own classes, and…

  9. Book Review: Book review

    Science.gov (United States)

    Manohar, C. S.

    2015-02-01

    The subject of the theory of vibrations has carried an aesthetic appeal to generations of engineering students for its richness of ideas, and for the intellectual challenges it offers. Also, the diverse range of its applications (covering civil, mechanical, automotive, and aerospace structures) has provided obvious motivations for its study. For most students, the subject provides, perhaps, the first encounter in substantial application of mathematical tools (differential equations, calculus of variations, Fourier/Laplace transforms, and matrix algebra) to engineering problems. The intimate relationship that the subject of mechanics has with mathematics strikes home probably for the first time. While teaching this subject, the instructor is spoilt for choice in selecting a text book and so are the students who wish to pursue a self-study of the subject. Many luminaries in the field have offered their own exposition of the subject: starting from the classics of Rayleigh, Timoshenko, Den Hartog, Bishop and Johnson, and the works of more recent vintage (e.g., the books by Meirovich, Clough, and Penzien, and works with computational flavour, such as, those by Bathe and Petyt), several works easily come to one's mind. Given this milieu, it requires a distinctive conviction to write a new book on this subject. And, here we have a book, written by a practitioner, which aims to deal with fundamental aspects of vibrations of engineering systems. The scepticism that this reviewer had on the need for having one more such book vanished as he browsed through the book and read selectively a few sections. The author's gift for elegant explanations is immediately noticeable even in such a preliminary reading. After a more careful reading, the reviewer has found this book to be insightful and he considers the book to be a welcome addition to the family of books on vibration engineering. The author has struck a fine balance between physical explanations, mathematical niceties

  10. Curriculum Reviews.

    Science.gov (United States)

    Riley, Joseph P.

    1983-01-01

    Reviews "Earthquakes and Volcanoes" (grades 3-6), "Metric Football" (a game), and "Happy Metrics I and II" (grades 4-6). Includes format, nature of activities, source, price, and reviewer's comments. (JN)

  11. Software Reviews.

    Science.gov (United States)

    Smith, Richard L., Ed.

    1985-01-01

    Reviews software packages by providing extensive descriptions and discussions of their strengths and weaknesses. Software reviewed include (1) "VISIFROG: Vertebrate Anatomy" (grade seven-adult); (2) "Fraction Bars Computer Program" (grades three to six) and (3) four telecommunications utilities. (JN)

  12. Research Review

    OpenAIRE

    Anonymous,

    1983-01-01

    Research Reviewed: "The Adjustment of Nominal Interest Rates to Inflation: A Review of Recent Literature"; "Role of Government in a Market Economy"; "Economic Analysis and Agricultural Policy"; "Agricultural Research Policy"

  13. Software Reviews.

    Science.gov (United States)

    Campion, Martin C.

    1985-01-01

    Reviews TIGERS IN THE SNOW: THE BATTLE OF THE BULGE (Strategic Simulations),and the BATTLE OF GETTYSBURG (Softwride). Each narrative review describes the hardware required and provides complete ordering information. (JDH)

  14. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2011-12-01

    Full Text Available Create Dangerously: The Immigrant Artist at Work, by Edwidge Danticat (reviewed by Colin Dayan Gordon K. Lewis on Race, Class and Ideology in the Caribbean, edited by Anthony P. Maingot (reviewed by Bridget Brereton Freedom and Constraint in Caribbean Migration and Diaspora, edited by Elizabeth Thomas-Hope (reviewed by Mary Chamberlain Black Europe and the African Diaspora, edited by Darlene Clark Hine, Trica Danielle Keaton & Stephen Small (reviewed by Gert Oostindie Caribbean Middlebrow: Leisure Culture and the Middle Class, by Belinda E dmondson (reviewed by Karla Slocum Global Change and Caribbean Vulnerability: Environment, Economy and Society at Risk, edited by Duncan McGregor, David Dodman & David Barker (reviewed by Bonham C. Richardson Encountering Revolution: Haiti and the Making of the Early Republic, by Ashli White (reviewed by Matt Clavin Red and Black in Haiti: Radicalism, Conflict, and Political Change, 1934-1957, by Matthew J. Smith (reviewed by Robert Fatton Jr. Cuba in the American Imagination: Metaphor and the Imperial Ethos, by Louis A. Pérez Jr. (reviewed by Camillia Cowling Seeds of Insurrection: Domination and Resistance on Western Cuban Plantations, 1808-1848, by Manuel Barcia (reviewed by Matt D. Childs Epidemic Invasions: Yellow Fever and the Limits of Cuban Independence, 1878-1930, by Mariola Espinosa (reviewed by Cruz Maria Nazario The Cuban Connection: Drug Trafficking, Smuggling, and Gambling in Cuba from the 1920s to the Revolution, by Eduardo Sáenz Rovner (reviewed by Ivelaw Lloyd Griffith Before Fidel: The Cuba I Remember, by Francisco José Moreno, and The Boys from Dolores: Fidel Castro’s Schoolmates from Revolution to Exile, by Patrick Symmes (reviewed by Pedro Pérez Sarduy Lam, by Jacques Leenhardt & Jean-Louis Paudrat (reviewed by Sally Price Healing Dramas: Divination and Magic in Modern Puerto Rico, by Raquel Romberg (reviewed by Grant Jewell

  15. Book reviews

    Directory of Open Access Journals (Sweden)

    T. Abdel-Motey., C. Urfels., K. Rodriguez., J. Mardikian., J.A. Drobnicki., V. Diodato.

    2000-10-01

    Full Text Available Title:(1 The Library and Information Professional’s Guide to the Internet. (2 Reinvention of the Public Library for the 21st Century. (3 Public Library Collection Development in the Information Age. (4 Making Sense of Journals in the Life Science: From Specialty Origins to Contemporary Assortment. (5 The Holocaust: Memories, Research, Reference. (6 How to Index Your Local Newspaper Using WordPerfect or Microsoft Word for Windows. (7 Effective Utilization and Management of Emerging Information Technologies. (8 Information Technology and Organizations: Challenges of New Technologies. (9 Facilities Planning for School Media and Technology Centers. (10 Libraries Without Walls 2: The Delivery of Library Services to Distance Users. (11 New International Directions in HIV Prevention for Gay and Bisexual Men. (12 Soaring to Excellence Videos: Tools of Our Trade III: Books, the Internet, and Beyond.Author:(1Reviewed by Teresa Abdel-Motey. (2Review by Claire Urfels. (3Reviewed by Dr. Ketty Rodriguez. (4Reviewed by Jackie Mardikian. (5Reviewed by John A. Drobnicki.(6Reviewed by Dr. Virgil Diodato. (7Reviewed by Dr. Lisa M. Covi. (8Reviewed by Tom Zillner. (9Reviewed by Dr. W. Bernard Lukenbill. (10Reviewed by Dr. Elizabeth Buchanan. (11Reviewed by Aisha White. (12Reviewed by Phyllis Tragash

  16. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2012-06-01

    Full Text Available The African Diaspora: A History Through Culture, by Patrick Manning (reviewed by Joseph C. Miller Atlas of the Transatlantic Slave Trade, by David Eltis & David Richardson (reviewed by Ted Maris-Wolf Abolition: A History of Slavery and Antislavery, by Seymour Drescher (reviewed by Gregory E. O’Malley Paths to Freedom: Manumission in the Atlantic World, edited by Rosemary Brana-Shute & Randy J. Sparks (reviewed by Matthew Mason You Are All Free: The Haitian Revolution and the Abolition of Slavery, by Jeremy D. Popkin (reviewed by Philippe R. Girard Fighting for Honor: The History of African Martial Arts in the Atlantic World, by T .J. Desch Obi (reviewed by Flávio Gomes & Antonio Liberac Cardoso Simões Pires Working the Diaspora: The Impact of African Labor on the Anglo-American World, 1650-1850, by Frederick C. Knight (reviewed by Walter Hawthorne The Akan Diaspora in the Americas, by Kwasi Konadu (reviewed by Ray Kea Tradition and the Black Atlantic: Critical Theory in the African Diaspora, by Henry Louis Gates Jr. (reviewed by Deborah A. Thomas From Africa to Jamaica: The Making of an Atlantic Slave Society, 1775-1807, by Audra A. Diptee (reviewed by D.A. Dunkley Elections, Violence and the Democratic Process in Jamaica 1944-2007, by Amanda Sives (reviewed by Douglas Midgett Caciques and Cemi Idols: The Web Spun by Taino Rulers between Hispaniola and Puerto Rico, by José R. Oliver (reviewed by Brian D. Bates The Latin American Identity and the African Diaspora: Ethnogenesis in Context, by Antonio Olliz Boyd (reviewed by Dawn F. Stinchcomb Reconstructing Racial Identity and the African Past in the Dominican Republic, by Kimberly Eison Simmons (reviewed by Ginetta E.B. Candelario Haiti and the Haitian Diaspora in the Wider Caribbean, edited by Philippe Zacaïr (reviewed by Catherine Benoît Duvalier’s Ghosts: Race, Diaspora, and U.S. Imperialism in Haitian Literatures, by Jana

  17. Frankenstein e cyborgs: pistas no caminho da ciência indicam o "novo eugenismo" Frankenstein and cyborgs: indications of new eugenism through the science Frankestein y cyborgs: huellas en el camino de la ciência que enseñan el nuevo eugenesismo

    Directory of Open Access Journals (Sweden)

    2006-11-01

    Full Text Available Este estudo analisa as atuais possibilidades de intervenções no corpo em busca de ampliá-lo, tornando-o mais bem adaptado às condições contemporâneas. Através das lentes da Eugenia do final do século XIX e início do XX, propomos buscar elementos que nos ajudem a pensar nossa atmosfera. De posse de reportagens coletadas em jornais e revistas de grande circulação e atentos aos dois períodos, identificamos muitas das novas tecnologias do corpo carreadoras de permanências daquilo que foi a busca pelo corpo melhorado. Denominadas “novo eugenismo”, as atuais introjeções tecnológicas assumem características próprias do nosso tempo, ao passo que guardam semelhanças profundas com aquilo que se chamou Eugenia. PALAVRAS-CHAVE: eugenia – ciência – adaptações do corpoF This study analyzes the current possibilities of interventions in the body that try enlarge it, turning it better adapted to contemporary conditions. Inspired in Eugenics of the end of the century XIX and beginning of the XX, we intend to look for us elements that help us to think our atmosphere. Through reports collected in newspapers and magazines of great circulation and attentive to the two periods, we identified that new technologies of the body carry permanences of that wel born science: Eugenics. Denominated “new eugenism”, the current body technologies assume own characteristics of our time, as well as keep deep similarities with science called Eugenia. KEY-WORDS: eugenics – science – body’s adaptations Este estudio analiza las posibilidades actuales de intervenciones en el cuerpo las cuales intentan extenderlo y de ahí haciéndolo mucho más adaptado a las condiciones contemporáneas. A través de las lentes de la Eugenesia del final del siglo XIX y comienzo del XX nos proponemos buscar elementos que nos ayuden a pensar nuestra atmósfera. Teniendo en las manos unos reportajes recolectados de periódicos y revistas de gran circulación y

  18. 从《榆树下的欲望》探讨尤金·奥尼尔对女性的人文关怀%Inquury unto Eugene O′Neull′s Humanustuc Care for Women from Desire Under the Elms

    Institute of Scientific and Technical Information of China (English)

    张媛

    2014-01-01

    Women′s social status is in the situation in which they are always dependent on men since patriarchal society,which is intolerable in this awakening feminism era.As the greatest American playwright,Eugene O′Neill shaped lots of women images,who are evil,crazy or extremely nervous, and he was criticized to be anti-women by feminism critics.But readers and audience can easily find Eugene O′Neill′s care for women when carefully studying his works.It′s of theoretical and realistic significance to interpret O′Neill′s humanistic care for women from feminist perspective in the expecta-tion of reflecting the characteristics of the modern times by analyzing the woman image,Abbie,in his famous work Desire Under the Elms .%进入父系社会以来,女性的社会地位总是处于依附男性的境地,这在女性主义觉醒的今天是令人难以容忍的。奥尼尔作为美国最伟大的戏剧家,在其作品中塑造了诸多女性形象,或罪恶或神经质或疯狂极端,因此被女性主义批评者认为是反女性的,可是细观奥尼尔的剧作,读者和观众不难发现他对女性的细腻关怀。从女权批评的角度入手,对奥尼尔剧作《榆树下的欲望》中女主人公爱碧的女性形象展开分析,以期从新的视觉展示奥尼尔对女性的人文关怀,并给出符合当今时代特征的现代解读。这既具有理论意义,也具有现实意义。

  19. La renovación de la fotografía española a partir de la pauta estética del realismo. Un precedente formal y significativo en el reportaje de Eugene Smith sobre Deleitosa (Cáceres

    Directory of Open Access Journals (Sweden)

    Francisco Javier Lázaro Sebastián

    2014-02-01

    Full Text Available A la hora de hablar de la renovación en la fotografía española a mediados del siglo XX, hay que tener en cuenta una pauta estética determinante para su consecución y que se deriva de la aplicación de posiciones realistas al arte. Frente al pictorialismo idealizador, el fotorreportaje se erige en crónica descarnada, no evitando una función crítica, de la situación actual, como ejemplifica el trabajo de Eugene Smith sobre el pueblo extremeño de Deleitosa. Entre los objetivos principales que se pretendía desarrollar, destacamos el dar a conocer algunos de los condicionantes históricos, ideológicos y estéticos de la fotografía desarrollada en España a mediados del siglo XX. La metodología de trabajo se ha basado en la consideración de los textos y las imágenes originales del reportaje citado, la bibliografía existente sobre el tema; comprender las reacciones surgidas en la prensa especializada del momento, y la relación con otras obras que también resultaron polémicas por su grado de realismo y de crítica social, por ejemplo, con algunas películas de Luis Buñuel.When we speak about the renovation of Spanish photography in the middle of the 20th century, it is necessary to bear in mind a concrete guideline which stems from idealized pictorialism to the realistic and even critical photographic chronicle. Certainly, it is a widespread phenomenon extended to other artistic manifestations like literature or the cinema. Inside the photographic plot, the photographic article constitutes the principal way to take it to effect. This emaciated chronicle which bears a critical function of the current situation is exemplified perfectly in the work of the North American Eugene Smith about Deleitosa.

  20. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2010-12-01

    Full Text Available The Atlantic World, 1450-2000, edited by Toyin Falola & Kevin D. Roberts (reviewed by Aaron Spencer Fogleman The Slave Ship: A Human History, by Marcus Rediker (reviewed by Justin Roberts Extending the Frontiers: Essays on the New Transatlantic Slave Trade Database, edited by David Eltis & David Richardson (reviewed by Joseph C. Miller "New Negroes from Africa": Slave Trade Abolition and Free African Settlement in the Nineteenth-Century Caribbean, by Rosanne Marion Adderley (reviewed by Nicolette Bethel Atlantic Diasporas: Jews, Conversos, and Crypto-Jews in the Age of Mercantilism, 1500-1800, edited by Richard L. Kagan & Philip D. Morgan (reviewed by Jonathan Schorsch Brother’s Keeper: The United States, Race, and Empire in the British Caribbean, 1937-1962, by Jason C. Parker (reviewed by Charlie Whitham Labour and the Multiracial Project in the Caribbean: Its History and Promise, by Sara Abraham (reviewed by Douglas Midgett Envisioning Caribbean Futures: Jamaican Perspectives, by Brian Meeks (reviewed by Gina Athena Ulysse Archibald Monteath: Igbo, Jamaican, Moravian, by Maureen Warner-Lewis (reviewed by Jon Sensbach Left of Karl Marx: The Political Life of Black Communist Claudia Jones, by Carole Boyce Davies (reviewed by Linden Lewis Displacements and Transformations in Caribbean Cultures, edited by Lizabeth Paravisini-Gebert & Ivette Romero-Cesareo (reviewed by Bill Maurer Caribbean Migration to Western Europe and the United States: Essays on Incorporation, Identity, and Citizenship, edited by Margarita Cervantes-Rodríguez, Ramón Grosfoguel & Eric Mielants (reviewed by Gert Oostindie Home Cooking in the Global Village: Caribbean Food from Buccaneers to Ecotourists, by Richard Wilk (reviewed by William H. Fisher Dead Man in Paradise: Unraveling a Murder from a Time of Revolution, by J.B. MacKinnon (reviewed by Edward Paulino Tropical Zion: General Trujillo, FDR, and the Jews of Sos