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Sample records for hussainov alexander kartushinsky

  1. Alexander Disease

    Science.gov (United States)

    ... may be other genetic or perhaps even non-genetic causes of Alexander disease. Current research is aimed at understanding the mechanisms by which the mutations cause disease, developing better animal models for the disorder, and exploring potential strategies ...

  2. Genetics Home Reference: Alexander disease

    Science.gov (United States)

    ... Email Facebook Twitter Home Health Conditions Alexander disease Alexander disease Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Alexander disease is a rare disorder of the nervous system. ...

  3. Herman Alexander Röell

    NARCIS (Netherlands)

    van Sluis, Jacob

    1988-01-01

    Leven en werk van Herman Alexander Röell (1653-1718), hoogleraar aan de universiteiten te Franeker en te Utrecht; zijn cartesiaanse theologie leidde tot hevige protesten vanuit gereformeerde orthodoxie.

  4. Alexander Street goes open access

    OpenAIRE

    Parker, David; Makowski, Jenna

    2016-01-01

    This article describes two complementary OA (open access) initiatives launching in 2016 at Alexander Street. Contributing Collections will see 10% of all revenue generated dedicated to digitizing and making OA important archives. Premium Services offer member libraries the opportunity to upload and make OA locally generated content. While this article focuses on the discipline of anthropology, Alexander Street will extend these two models into history, music and theater later in 2016. 

  5. Alexander Street goes open access

    Directory of Open Access Journals (Sweden)

    David Parker

    2016-03-01

    Full Text Available This article describes two complementary OA (open access initiatives launching in 2016 at Alexander Street. Contributing Collections will see 10% of all revenue generated dedicated to digitizing and making OA important archives. Premium Services offer member libraries the opportunity to upload and make OA locally generated content. While this article focuses on the discipline of anthropology, Alexander Street will extend these two models into history, music and theater later in 2016.

  6. Interview with Alexander Cohen.

    Science.gov (United States)

    Cohen, Alexander Ander

    2017-05-01

    Ander Cohen speaks to Adam Price-Evans, Commissioning Editor of Future Cardiology: Alexander (Ander) Cohen MBBS (Hons), MSc, MD, FRACP is a vascular physician and epidemiologist at Guy's and St Thomas' Hospital, King's College (London, UK). He graduated with honors in medicine and honors in surgery from the University of Melbourne, Australia, and became a fellow of the Royal Australasian College of Physicians in 1990. He was awarded an MSc in Epidemiology from the London School of Hygiene and Tropical Medicine, University of London in 1991 with a thesis on the metabolic syndrome in South-Asian populations. In 1998, he was awarded an MD with a thesis on the epidemiology of venous thromboembolism and thromboprophylaxis. In addition to his clinical work, he is involved in designing, managing and analyzing clinical trials from Phase I to IV. He is the Chairman and a member of many international steering committees for multicenter trials, epidemiological and pharmacoeconomic studies, and was previously the Director of Clinical Research and an Epidemiologist in Thrombosis Research at King's College Hospital.

  7. Fibred knots and twisted Alexander invariants

    OpenAIRE

    Cha, Jae Choon

    2001-01-01

    We introduce a new algebraic topological technique to detect non-fibred knots in the three sphere using the twisted Alexander invariants. As an application, we show that for any Seifert matrix of a knot with a nontrivial Alexander polynomial, there exist infinitely many non-fibered knots with the given Seifert matrix. We illustrate examples of knots that have trivial Alexander polynomials but do not have twisted Alexander invariants of fibred knots.

  8. Alexander duals of multipermutohedron ideals

    Indian Academy of Sciences (India)

    for all the multigraded Betti numbers of an Alexander dual of multipermutohedron ideals are also obtained. ... the permutohedron ideal I(1, 2,...,n) with respect to n = (n, n, . . . , n) is given by. I(1, 2,...,n). [n] = 〈. (∏ .... of the Betti numbers of multipermutohedron ideals and characterization of minimality of the cellular resolution ...

  9. Neurocognitive decline in Alexander disease.

    Science.gov (United States)

    Restrepo, June; Bernardin, Linda; Hammeke, Thomas

    2011-10-01

    Alexander disease is a neurological condition associated with prominent white matter deterioration. Its rarity and relatively rapid disease course have provided limited understanding into the cognitive effects of the illness. We report the serial neuropsychological findings of a 21-year-old with normal development and no medical history until age 9, when he experienced refractory sinusitis, stabbing headaches with vertigo, disorientation, and decline in academic and social settings. An MRI scan of the brain found acute demyelinating encephalomyelitis, with a preponderance of white matter degeneration in the bilateral frontal lobes. Interval MRIs showed continued degeneration. Confirmation of Alexander disease was made at age 20 through genetic testing. Four evaluations completed from ages 15 to 21 showed impairment across all cognitive domains. Cognitive deficits were most prominent in new learning and recent memory, executive functions, and fine motor dexterity, and less apparent in information processing and visual scanning speed. These results present evidence for a particular cognitive pattern in individuals with juvenile-onset Alexander disease. Despite extensive white matter degeneration in the frontal lobes, certain tasks associated with frontal lobe integrity were relatively preserved. Further research into the neuropsychological presentation of the subtypes of Alexander disease can enhance diagnostic clarity and treatment planning.

  10. Alexander technique for chronic asthma.

    Science.gov (United States)

    Dennis, Jane A; Cates, Christopher J

    2012-09-12

    'The Alexander technique' is a taught form of physical therapy involving a series of movements designed to correct posture and bring the body into natural alignment with the object of helping it to function efficiently, and is reported to aid relaxation. Some practitioners claim benefits for those who desire greater ease and efficiency of breathing, including asthmatics. The objective of this review was to evaluate the efficacy of the Alexander technique in people with chronic, stable asthma. We searched the Cochrane Airways Group Specialised Register, the Cochrane Complementary Medicine Field trials register and the bibliographies of relevant articles. The most recent search was run in June 2012. Randomised controlled trials of Alexander technique (AT) for the improvement of the symptoms of chronic, stable asthma, comparing the treatment with either another intervention or no intervention. No trials were found that met the selection criteria. No meta-analysis could be performed. Robust, well-designed randomised controlled trials are required in order to test claims by practitioners that AT can have a positive effect on the symptoms of chronic asthma and thereby help people with asthma to reduce medication.

  11. Alexander disease: diagnosis with MR imaging

    NARCIS (Netherlands)

    van der Knaap, M. S.; Naidu, S.; Breiter, S. N.; Blaser, S.; Stroink, H.; Springer, S.; Begeer, J. C.; van Coster, R.; Barth, P. G.; Thomas, N. H.; Valk, J.; Powers, J. M.

    2001-01-01

    To date, the demonstration of Rosenthal fibers on brain biopsy or autopsy specimens is considered a prerequisite for a definitive diagnosis of Alexander disease. We initiated a multiinstitutional survey of MR abnormalities in both presumed and confirmed cases of Alexander disease to assess the

  12. Alexander disease : Diagnosis with MR imaging

    NARCIS (Netherlands)

    van der Knaap, MS; Naidu, S; Breiter, SN; Blaser, S; Stroink, H; Spinger, S; Begeer, JC; van Coster, R; Barth, PG; Thomas, NH; Powers, JM; Valk, J.

    BACKGROUND AND PURPOSE: To date, the demonstration of Rosenthal fibers on brain biopsy or autopsy specimens is considered a prerequisite for a definitive diagnosis of Alexander disease. We initiated a multiinstitutional survey of MR abnormalities in both presumed and confirmed cases of Alexander

  13. Dancers' Application of the Alexander Technique

    Science.gov (United States)

    Fortin, Sylvie; Girard, Fernande

    2005-01-01

    This qualitative study describes the experience of professional contemporary dancers studying and applying the Alexander Technique to their dancing. This study was motivated by: 1. years of teaching both dance and somatics, 2. a strong desire to better understand how the Alexander Technique can be applied by dancers, and 3. a gap that the…

  14. The Alexander Technique: An Acting Approach.

    Science.gov (United States)

    Barker, Sarah A.

    2002-01-01

    Notes the discrepancy between students' use of the Alexander Technique in class and on stage. Discusses three fundamental self-use objectives of the Alexander Technique: the reduction of excess physical compression and muscularity; the unification of body/voice and thought; and the expansion of the field of attention. Demonstrates how each…

  15. Juvenile alexander disease: a case report.

    Science.gov (United States)

    Ozkaya, Halit; Akcan, Abdullah Baris; Aydemir, Gokhan; Kul, Mustafa; Aydinoz, Secil; Karademir, Ferhan; Suleymanoglu, Selami

    2012-04-01

    Alexander disease is a rare autosomal recessive disorder that is characterized by degeneration of the white matter in the central nervous system. Alexander disease is a leukodystrophy that is usually observed in early childhood but rarely in adults. It is characterized by megalencephaly, demyelinization and multiple Rosenthal fibers. Specific magnetic resonance imaging (MRI) findings and genetic investigations are necessary to diagnose the disorder. Signs of leukodystrophy were found in the bilateral white matter on a brain MRI of our four-year-old patient. He had megalencephaly since birth. We use this case to discuss Alexander disease.

  16. Did Alexander the Great read Xenophon?

    OpenAIRE

    McGroarty, Kieran

    2006-01-01

    It has been assumed by writers, ancient and modern, that Xenophon’s literary output had a direct influence on Alexander the Great. But is there any evidence to prove that it did? In spite of the paucity of references to Xenophon in the surviving Alexander sources, many writers, both ancient and modern, have no doubts concerning the influence of Xenophon’s writings on Alexander. An extreme position is suggested by Eunapius, the sophist and historian born at Sardis c. AD 345, when he says in hi...

  17. An unusual presentation of juvenile Alexander disease.

    Science.gov (United States)

    Osorio, Maria Joana; Risen, Sarah; Alper, Gulay

    2012-04-01

    Alexander disease is a rare leukodystrophy that most often presents in infancy but also includes neonatal, juvenile, and adult variants. Juvenile Alexander disease presents primarily with bulbar symptoms between 2 and 12 years of age. The diagnosis is often suggested by the clinical course and brain magnetic resonance image pattern and then confirmed by the presence of a mutation in the glial fibrillary acidic protein gene. A young girl presented with globus sensation and magnetic resonance imaging of the brain revealed abnormalities mainly involving white matter tracts of the medulla oblongata and cerebellum. The presence of a mutation in the glial fibrillary acidic protein gene confirmed the diagnosis of juvenile Alexander disease. A high index of clinical suspicion is necessary for the diagnosis of late-onset presentations of Alexander disease.

  18. Myelin changes in Alexander disease.

    Science.gov (United States)

    Gómez-Pinedo, U; Duran-Moreno, M; Sirerol-Piquer, S; Matias-Guiu, J

    2017-03-22

    Alexander disease (AxD) is a type of leukodystrophy. Its pathological basis, along with myelin loss, is the appearance of Rosenthal bodies, which are cytoplasmic inclusions in astrocytes. Mutations in the gene coding for GFAP have been identified as a genetic basis for AxD. However, the mechanism by which these variants produce the disease is not understood. The most widespread hypothesis is that AxD develops when a gain of function mutation causes an increase in GFAP. However, this mechanism does not explain myelin loss, given that experimental models in which GFAP expression is normal or mutated do not exhibit myelin disorders. This review analyses other possibilities that may explain this alteration, such as epigenetic or inflammatory alterations, presence of NG2 (+) - GFAP (+) cells, or post-translational modifications in GFAP that are unrelated to increased expression. The different hypotheses analysed here may explain the myelin alteration affecting these patients, and multiple mechanisms may coexist. These theories raise the possibility of designing therapies based on these mechanisms. Copyright © 2017 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  19. The Mind-Body Connection: An Introduction to Alexander Technique.

    Science.gov (United States)

    Madden, Cathy

    2003-01-01

    Explains that the Alexander Technique is a process that allows performers to improve physical-mental coordination while performing. Outlines the fundamentals of the Alexander Technique and how it can be applied for actors and drama teachers. Proposes that drama teachers can incorporate some of the Alexander Technique's fundamentals into their…

  20. Alexander Technique and Dance Technique: Applications in the Studio

    Science.gov (United States)

    Nettl-Fiol, Rebecca

    2006-01-01

    Integrating principles from the Alexander Technique into a dance technique class can provide tools for facilitating a more coordinated use of the self. While the methodologies of Alexander Technique and dance technique may present differences, there are ways of applying the principles of Alexander within the context of a dance technique class that…

  1. Sir Alexander Fleming - Biologia (1881-1955)

    OpenAIRE

    Nobre, Alexandra

    2008-01-01

    Biografia inserida na brochura produzida para acompanhar a exposição "Faces da Ciência" - (actividade do projecto Sentidos da Ciência - ECUM) Biografia de Sir Alexander Fleming nas suas componentes: o homem e a obra. Fundação para a Ciência e a Tecnologia (FCT)

  2. Acute onset of adult Alexander disease.

    Science.gov (United States)

    Schmidt, Holger; Kretzschmar, Benedikt; Lingor, Paul; Pauli, Silke; Schramm, Peter; Otto, Markus; Ohlenbusch, Andreas; Brockmann, Knut

    2013-08-15

    Adult-onset Alexander disease (AOAD) is a rare leukoencephalopathy affecting predominantly the brainstem and cervical cord with insidious onset of clinical features. Acute onset is very rare and has yet been described only twice, to our knowledge. We report a 32-year-old hitherto healthy male who, after excessive consumption of alcohol, presented with stroke-like onset of symptoms including rigidospasticity, loss of consciousness, and bulbar dysfunction. MRI features comprised bilateral T2-hyperintensities of frontal white matter and basal ganglia as well as atrophy of medulla oblongata with a peculiar "tadpole" appearance, a pattern characteristic of AOAD. Mutation analysis of the GFAP gene revealed a heterozygous de novo 9-bp microduplication in exon 1. Adult Alexander disease may present with stroke-like features. MRI patterns of chronic neurodegenerative conditions may be recognizable even in acute neurological emergencies. Copyright © 2013 Elsevier B.V. All rights reserved.

  3. Strategies for treatment in Alexander disease.

    Science.gov (United States)

    Messing, Albee; LaPash Daniels, Christine M; Hagemann, Tracy L

    2010-10-01

    Alexander disease is a rare and generally fatal disorder of the CNS, originally classified among the leukodystrophies because of the prominent myelin deficits found in young patients. The most common form of this disease affects infants, who often have profound mental retardation and a variety of developmental delays, but later onset forms also occur, sometimes with little or no white matter pathology at all. The pathological hallmark of Alexander disease is the inclusion body, known as Rosenthal fiber, within the cell bodies and processes of astrocytes. Recent genetic studies identified heterozygous missense mutations in glial fibrillary acidic protein (GFAP), the major intermediate filament protein in astrocytes, as the cause of nearly all cases of Alexander disease. These studies have transformed our view of this disorder and opened new directions for investigation and clinical practice, particularly with respect to diagnosis. Mechanisms by which expression of mutant forms of glial fibrillary acidic protein (GFAP) lead to the pleiotropic manifestations of disease (afflicting cell types beyond the ones expressing the mutant gene) are slowly coming into focus. Ideas are beginning to emerge that suggest several compelling therapeutic targets for interventions that might slow or arrest the evolution of the disease. This review will outline the rationale for pursuing these strategies, and highlight some of the critical issues that must be addressed in the planning of future clinical trials. Copyright © 2010 The American Society for Experimental NeuroTherapeutics, Inc. Published by Elsevier Inc. All rights reserved.

  4. Focal central white matter lesions in Alexander disease.

    Science.gov (United States)

    Barreau, Pauline; Prust, Morgan J; Crane, Jeremy; Loewenstein, Johanna; Kadom, Nadja; Vanderver, Adeline

    2011-11-01

    Alexander disease is a neurodegenerative disorder of the central white matter caused by dominant mutations in GFAP, the gene encoding glial fibrillary acidic protein. Magnetic resonance imaging pattern recognition studies have established characteristic radiologic phenotypes for this disorder. In some cases, however, genetically confirmed cases do not express these features, and several reports have identified "atypical" radiologic findings in Alexander disease patients. Here, the authors report 3 genetically confirmed Alexander disease cases with focal central white matter lesions that, upon longitudinal clinical and radiologic evaluation, appear to reflect an atypical Alexander disease magnetic resonance imaging phenotype and not another pathophysiologic process such as encephalitis, infarction, or neoplasm.

  5. Alexander Graham Bell (170th birthday anniversary

    Directory of Open Access Journals (Sweden)

    V. P. Samokhin

    2017-01-01

    Full Text Available A brief overview of the main works and achievements of Alexander Graham Bell, an educated teacher for the hard of hearing and public figure, author of 30 US patents, is mainly given in the field of telephony and sound recording and reproduction. Biographical information about the Bell family, as well as some interesting facts from his life and activities are given. Scotsman by birth, A. Bell from his youthful years was carried away by the acoustic features of the human voice apparatus and devoted his entire life to teaching the deaf to the perception of oral speech. The first success in this field Bell reached, opening a private school for the deaf in Boston. Bell's creation of the phone was the result of his attempts to facilitate communication with the hard-of-hearing and led to the development of mass communications technology around the world. Alexander Bell is also known for his achievements in the design of hydroplanes, hydrofoils and as one of the founders of the popular magazine National Geographic. He was awarded many honorable awards and academic titles.

  6. Studying the multivariable Alexander polynomial by means of Seifert surfaces

    OpenAIRE

    Cimasoni, David

    2004-01-01

    We show how Seifert surfaces, so useful for the understanding of the Alexander polynomial \\Delta_L(t), can be generalized in order to study the multivariable Alexander polynomial \\Delta_L(t_1,...,t_\\mu). In particular, we give an elementary and geometric proof of the Torres formula.

  7. THE DEATH OF ALEXANDER THE GREAT 1. INTRODUCTION

    African Journals Online (AJOL)

    The circumstances of Alexander's death are reviewed. Since contemporary sources vary in their accounts of the reason for his death, they are briefly reviewed and assessed. The account of Alexander's final illness is then discussed as recorded in the King's. Journal and the Liber de morte testamentumque Alexandri Magni.

  8. Abenteuer Alexander-von-Humboldt-Bibliographie

    Directory of Open Access Journals (Sweden)

    Christian Suckow

    2002-04-01

    Full Text Available Article in German; Abstracts in English and German.The two attempts (1860 and 1872 to compile a bibliography of all works of Alexander von Humboldt have to be regarded as failures. Due to Humboldt’s scientific methods, the contemporary popularity of his writings, and the conditions of book publishing and selling, it has been difficult to achieve an overview of his œuvre. Thus each attempt to write a reliable or at least partially complete bibliography of Humboldt’s works constituted an adventure. Horst Fiedler and Ulrike Leitner have mastered this undertaking. As a result of their efforts over more than two decades, a bibliography of those works by Humboldt which were published in book form appeared in the year 2000.

  9. Alexander Klein: German in the Makhnovist movement

    Directory of Open Access Journals (Sweden)

    Arkhireyskyi, D. V.

    2015-05-01

    Full Text Available Highlights the life of Alexander Klein, a descendant of German colonists, Makhno’s active insurgency. Analyzed the possible reasons for his joining the group of anarchists Huliaipole. Participating of O. Kleyn in detachments of the Black household troops in southern Ukraine on verge of 1917–1918 is examined. The battle way of insurgent in the soldiery formings of army of N. Makhno is traced. His participating in all the most important campaigns and battle of insurgent army inclusive to the day of death in August 1921 lights up. The most interesting events of revolutionary war, this insurgent commander took part in which, are considered. Confirmed A. Kleyn loyalty, in spite of his national belonging, and the ideals of the Makhnovist insurgency.

  10. Alexander von Humboldt in Daniel Kehlmanns Welt

    Directory of Open Access Journals (Sweden)

    Ottmar Ette

    2012-12-01

    Full Text Available Zusammenfassung Wie stark sich im Verlauf des zurückliegenden Vierteljahrhunderts der Bekanntheitsgrad Alexander von Humboldts in der deutschsprachigen Öffentlichkeit verändert hat, zeigen nicht nur Fernsehumfragen zu den berühmtesten Deutschen, in denen Alexander von Humboldt mittlerweile figuriert, oder Fernsehserien, die über aktuelle Expeditionen berichten und auf Humboldts Namen zurückgreifen. Am deutlichsten vielleicht belegt dies der enorme Erfolg von Daniel Kehlmanns Roman Die Vermessung der Welt, der ohne die zuvor skizzierte Entwicklung nicht denkbar gewesen wäre. Es ist vor diesem Hintergrund nicht nur reizvoll, sondern aufschlußreich, sich mit dem großen Erfolg dieses kleinen Romans zu beschäftigen. Worum geht es in Die Vermessung der Welt? Und wie läßt sich das „Phänomen Kehlmann“ aus etwas größerer Distanz erklären? Abstract In the last 25 years, Alexander von Humboldt‘s popularity has radically changed in the german-speaking public opinion. Proof of this are not only television surveys about the most famous germans - in which Alexander von Humboldt now regularly figures - or television series about contemporary expeditions, which constantly refer to Humboldt‘s name; perhaps what most clearly verifies this change is the great success of Daniel Kehlmann‘s novel Die Vermessung der Welt. Without the recent developments outlined above, this novel‘s degree of impact would have been unimaginable. To study the great success of this text against this backdrop is not only attractive, but also revealing. What is Die Vermessung der Welt really about? And how can we explain the „Kehlmann phenomenon“ from a greater distance? Resumen La popularidad de Alejandro de Humboldt ha cambiado profundamente dentro del último cuarto de siglo en la opinión pública de habla alemana. Prueba de esto son no sólo las encuestas televisivas sobre los alemanes más famosos, dentro de las cuales figura en estos momentos Alejandro

  11. Conversations in History: Arrian and Herodotus, Parmenio and Alexander

    Directory of Open Access Journals (Sweden)

    Janet D. Chaplin

    2011-11-01

    Full Text Available Arrian’s account of Parmenio’s warning to Alexander at Persepolis is meant not only to evoke Herodotus’ account of Croesus and Cyrus, but also to critique Herodotus’ notion of endless reciprocity in history.

  12. Port Alexander, Alaska Tsunami Forecast Grids for MOST Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Port Alexander, Alaska Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST) model....

  13. Alexander in the Tychaion: Ps.-Libanius on the Statues

    Directory of Open Access Journals (Sweden)

    Craig A. Gibson

    2010-11-01

    Full Text Available Of the statues in the precinct of Tyche in Alexandria, described by [Lib.] Ecphr. 25, the "founder" holding the token of the "Soter" is not Ptolemy I but Alexander in the guise of Zeus.

  14. Leni Alexander Pollack (1924-2005

    Directory of Open Access Journals (Sweden)

    Raquel Bustos Valderrama

    2007-06-01

    Full Text Available El estudio de Leni Alexander Pollack, considerada la compositora nacional más importante del siglo XX, expande y profundiza nuestro conocimiento del aporte de la mujer a la creación musical chilena. En el presente trabajo las entrevistas personales fueron no sólo la fuente primaria para obtener los antecedentes biográficos iniciales, sino también una oportunidad para discutir y aclarar asuntos de estética, tendencias y estilo. Sobre estas bases se analizan tres obras específicas, consideradas como demarcatorias de la evolución de sus recursos creativos. El catálogo de sus obras es una muestra vívida de la gran versatilidad de la compositora en el libre uso de los parámetros musicales, como elementos básicos generadores de toda una obra y, a la vez, en las sugerencias que hace a los instrumentistas- intérpretes o a los actores de su hörspiel o "teatro para escuchar". En suma, sus composiciones y escritos académicos, a los que se agrega la difusión radial comentada de la música contemporánea en Chile y en el extranjero, confirman su calidad de representante itinerante y portavoz de la vanguardia musical del siglo XXLeni Alexander Pollack, has been considered the most important national female composer of the 20th century. The study of her musical composition has contributed to further our knowledge of women's contributions to musical creation in Chile. For the present paper, personal interviews were not only a primary source for the initial biographical information, but also an opportunity to discuss with the composer topics related to aesthetics, tendencies and style. Upon these bases, three specific works are analyzed, which are considered turning points in the evolution of her creative resources. The catalog of her work is a vivid demonstration of her versatility in the free use of musical parameters, which can be seen as basic element in the generation of complete works, as well as in the suggestions she offers to the

  15. ALEXANDER IN AFGHANISTAN Frank L. Holt, Alexander the Great and the Mystery of the Elephant Medallions. Hellenistic Culture and Society 44. Berkeley: University of California Press, 2003

    National Research Council Canada - National Science Library

    John Atkinson

    2006-01-01

    .... [...] he covers Kaiser's line that the reverse image depicted Alexander in Homeric guise (pp. 70f.), Pandey's case that the battle scene referred to Alexander's victory over Darius at Gauagamela...

  16. Clinical and genetic study in Chinese patients with Alexander disease.

    Science.gov (United States)

    Ye Wu; Qiang Gu; Jingmin Wang; Yanling Yang; Xiru Wu; Yuwu Jiang

    2008-02-01

    Alexander disease is a rare progressive leukoencephalopathy inherited in an autosomal dominant manner. The infantile form is the most common, with onset before 2 years of age. The typical clinical signs include psychomotor retardation and regression, seizures, and megalencephaly. Juvenile and adult forms are also recognized. The neuropathology of Alexander disease is characterized by abundant presence of Rosenthal fibers in astrocytes in the brain. GFAP has been identified to be the only gene associated with Alexander disease since 2001. Only 1 patient with Alexander disease confirmed by genetic testing has been reported in mainland China. To get further information of the clinical and genetic characteristics of Chinese patients, we analyzed an additional 3 cases with the infantile or juvenile form. A novel mutation, Y83H, and a previously reported mutation, R88C, were identified in these patients. Both mutations were heterozygous and de novo. The results of this research expand the number of patients with Alexander disease found to have GFAP coding mutations in mainland China. A novel missense mutation, Y83H, is identified.

  17. Obituary: Donald Alexander Macrae, 1916-2006

    Science.gov (United States)

    Seaquist, E. R.

    2007-12-01

    With the passing of Donald Alexander MacRae on 6 December 2006 at age 90, the astronomy community lost a visionary scientist and a great educator in the field. Don MacRae was born in Halifax, Nova Scotia, on 19 February 1916, to Donald Alexander and Laura Geddes (Barnstead) MacRae. His father was originally a classics scholar and preceptor of Greek and Latin at Princeton, but at the time of Don's birth in 1916 he was Dean of the Dalhousie Law School in Halifax. The family moved to Toronto, Ontario, in 1924 when his father joined the faculty of Osgoode Hall Law School in Toronto as a Professor of Law. After the family moved to Toronto, where he received most of his early education, he obtained his undergraduate degree in Mathematics and Physics in 1937 from the University of Toronto (U of T). He obtained the degree of A.M. in 1940 and of Ph.D. in 1943 from Harvard University under the mentorship of Bart Bok in the field of galactic structure. During his early career he worked briefly at the University of Pennsylvania, Cornell University, and Carbide and Chemical Corporation at Oak Ridge, Tennessee. For Don the latter work was a brief and somewhat uneasy association with the Manhattan Project. In 1946, he obtained a position at Case Institute of Technology (now Case Western Reserve University), where he worked until 1953. In 1953, he accepted a position at the U of T, replacing Ralph Williamson, who had earlier introduced Don to the emerging field of radio astronomy while they both were at Cornell. Don's primary research field was stellar spectroscopy, but his interests were much broader than this, and he possessed an abiding ability to interest students and faculty in new and emerging ideas. In the early 1960s he developed a strong interest in the nature and origin of the lunar surface, and discussed these extensively with colleagues. Many of his ideas on this subject were later confirmed by the lunar exploration program. Don's continuing interest in radio astronomy

  18. Sir Alexander Fleming: Scottish researcher who discovered penicillin.

    Science.gov (United States)

    Ligon, B Lee

    2004-01-01

    The discovery and development of penicillin changed the entire direction of approaches to treating infectious diseases and saved the lives of millions of people. Indeed, the development of penicillin was a watershed event in the battle against infectious diseases, and the individual who discovered it, Sir Alexander Fleming, remains a prominent individual in the annals of medical history. This article focuses primarily on the personal life of Alexander Fleming, an individual who had a remarkable diversity of interests and who made many contributions to science and medicine.

  19. Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes.

    Science.gov (United States)

    Kondo, Takayuki; Funayama, Misato; Miyake, Michiyo; Tsukita, Kayoko; Era, Takumi; Osaka, Hitoshi; Ayaki, Takashi; Takahashi, Ryosuke; Inoue, Haruhisa

    2016-07-11

    Alexander disease is a fatal neurological illness characterized by white-matter degeneration and formation of Rosenthal fibers, which contain glial fibrillary acidic protein as astrocytic inclusion. Alexander disease is mainly caused by a gene mutation encoding glial fibrillary acidic protein, although the underlying pathomechanism remains unclear. We established induced pluripotent stem cells from Alexander disease patients, and differentiated induced pluripotent stem cells into astrocytes. Alexander disease patient astrocytes exhibited Rosenthal fiber-like structures, a key Alexander disease pathology, and increased inflammatory cytokine release compared to healthy control. These results suggested that Alexander disease astrocytes contribute to leukodystrophy and a variety of symptoms as an inflammatory source in the Alexander disease patient brain. Astrocytes, differentiated from induced pluripotent stem cells of Alexander disease, could be a cellular model for future translational medicine.

  20. Obituary: Walter Alexander Feibelman, 1930-2004

    Science.gov (United States)

    Oergerle, William

    2005-12-01

    Walter Alexander Feibelman, 79, an astronomer who discovered the E-ring of Saturn, died of a heart attack 19 November 2004 at his home at Riderwood Village in Silver Spring, Maryland. Walter was born 30 October 1925 in Berlin, Germany to Bernard and Dora Feibelman. He came to the United States with his parents in 1941. They were some of the last German Jews to flee Nazi Germany. Years later, he reported his experiences in an account contributed to the U.S. Holocaust Memorial Museum. As a youth, he worked at a cleaning shop and as a soda jerk before taking a course in tool and die making. He worked at the Abbey Photo Corp. in New York and in a model-making firm, where he constructed models of aircraft for use in identification courses by the Army Air Forces. After high school, he attended the Carnegie Institute of Technology and received his BS degree in 1956. Until 1969, he was a research scientist at the University of Pittsburgh. While working as an assistant research professor in physics and astronomy at the University of Pittsburgh in 1967, he examined a photo of Saturn taken a year earlier at the university's Allegheny Observatory. The E-ring -- unlike the bright main rings, A, B, C, D and F -- is faint and not easily spotted. He paired his observation with calculations and announced his discovery, which remained unconfirmed until the Pioneer 11 flyby in 1979. Walter joined the Optical Astronomy Division of Goddard Space Flight Center in Greenbelt in 1969, and worked there until 2002, when he became an emeritus astronomer at NASA. He became associated with the International Ultraviolet Explorer project, and worked on developing detectors for the orbiting observatory's spectrograph. The project turned out to be one of NASA's most successful observatories, operating from 1978 to 1996. In his scientific career, he published more than 200 refereed articles, mainly on hot stars and planetary nebulae. He also wrote papers in the fields of photography, spectroscopy

  1. Alexander Meiklejohn in Search of Freedom and Dignity.

    Science.gov (United States)

    Johnson, Tony W.

    1982-01-01

    Assesses the contributions of the philosopher/educator Alexander Meiklejohn. Discusses the influences of Jean-Jacques Rousseau, Immanuel Kant, and the U.S. Constitution on Meiklejohn's educational theories, which stressed that human freedom and dignity can be enhanced by rigorous examination of U.S. Supreme Court decisions and the meaning of…

  2. Alexander disease with mild dorsal brainstem atrophy and infantile spasms.

    Science.gov (United States)

    Torisu, Hiroyuki; Yoshikawa, Yoko; Yamaguchi-Takada, Yui; Yano, Tamami; Sanefuji, Masafumi; Ishizaki, Yoshito; Sawaishi, Yukio; Hara, Toshiro

    2013-05-01

    We present the case of a Japanese male infant with Alexander disease who developed infantile spasms at 8 months of age. The patient had a cluster of partial seizures at 4 months of age. He presented with mild general hypotonia and developmental delay. Macrocephaly was not observed. Brain magnetic resonance imaging (MRI) findings fulfilled all MRI-based criteria for the diagnosis of Alexander disease and revealed mild atrophy of the dorsal pons and medulla oblongata with abnormal intensities. DNA analysis disclosed a novel heterozygous missense mutation (c.1154 C>T, p.S385F) in the glial fibrillary acidic protein gene. At 8 months of age, tonic spasms occurred, and electroencephalography (EEG) revealed hypsarrhythmia. Lamotrigine effectively controlled the infantile spasms and improved the abnormal EEG findings. Although most patients with infantile Alexander disease have epilepsy, infantile spasms are rare. This comorbid condition may be associated with the distribution of the brain lesions and the age at onset of Alexander disease. Copyright © 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

  3. Review of Alexander disease: beyond the classical concept of leukodystrophy.

    Science.gov (United States)

    Sawaishi, Yukio

    2009-08-01

    Alexander disease is classified as one of the leukodystrophies, which are degenerative diseases primarily affecting the cerebral white matter. Formal diagnosis is achieved by showing diffuse accumulation of Rosenthal fibers in the brain by biopsy or autopsy. Showing a heterozygous mutation in the glial fibrillary acidic protein (GFAP) gene is currently sufficient for diagnosis. The mechanisms of Rosenthal fiber formation remain unclear. However, both the quality and quantity of GFAP are important. GFAP-epsilon (rodent homologous GFAP-delta), one of the alternatively spliced GFAP isoforms, may also play a modulating role in aggregate formation. The current ease of diagnosis has accelerated the accumulation of a wide variety of patients with Alexander disease along with the widespread use of MRI. In contrast to the classical infantile type, patients with juvenile and adult types mainly complain of bulbar symptoms and usually show progressive atrophy of the lower brainstem and cervical spinal cord with mild or minimal leukodystrophic changes. Among the many MRI findings of Alexander disease, periventricular linear lesions with various names depending on the thickness and shape seem to represent the unique pathophysiology, because the subventricular zone of the adult human brain includes special astrocytes that behave as multipotent progenitor cells and specifically produce GFAP-epsilon. Except for a few mutations, no clear phenotype-genotype correlation has been established for Alexander disease, although male preponderance in the infantile type suggests that phenotypes may be partly affected by gender.

  4. A complex-network perspective on Alexander's wholeness

    Science.gov (United States)

    Jiang, Bin

    2016-12-01

    The wholeness, conceived and developed by Christopher Alexander, is what exists to some degree or other in space and matter, and can be described by precise mathematical language. However, it remains somehow mysterious and elusive, and therefore hard to grasp. This paper develops a complex network perspective on the wholeness to better understand the nature of order or beauty for sustainable design. I bring together a set of complexity-science subjects such as complex networks, fractal geometry, and in particular underlying scaling hierarchy derived by head/tail breaks - a classification scheme and a visualization tool for data with a heavy-tailed distribution, in order to make Alexander's profound thoughts more accessible to design practitioners and complexity-science researchers. Through several case studies (some of which Alexander studied), I demonstrate that the complex-network perspective helps reduce the mystery of wholeness and brings new insights to Alexander's thoughts on the concept of wholeness or objective beauty that exists in fine and deep structure. The complex-network perspective enables us to see things in their wholeness, and to better understand how the kind of structural beauty emerges from local actions guided by the 15 fundamental properties, and in particular by differentiation and adaptation processes. The wholeness goes beyond current complex network theory towards design or creation of living structures.

  5. Alexander von Humboldt's invention of the natural landscape

    NARCIS (Netherlands)

    Kwa, C.

    2005-01-01

    Landscape took on a new meaning through the new science of plant geography of Alexander von Humboldt (1769-1857). In the seventeenth and eighteenth centuries, "landscape" was foremost a painterly genre. Slowly, painted landscapes came to bear on natural surroundings, but by 1800 it was still not

  6. Teaching Nuclear Radiation and the Poisoning of Alexander Litvinenko

    Science.gov (United States)

    David R. Lapp

    2008-01-01

    The recent international story about the death of the former KGB agent Alexander Litvinenko has more than just a few wondering about radiation poisoning and the sinister sounding polonium-210. I was preparing to begin a nuclear radiation unit the Monday after Thanksgiving 2006. As it turned out, Litvinenko died Thanksgiving Day after a short and…

  7. The transport glider | Alexander | Scientia Militaria: South African ...

    African Journals Online (AJOL)

    Scientia Militaria: South African Journal of Military Studies. Journal Home · ABOUT · Advanced Search · Current Issue · Archives · Journal Home > Vol 10, No 2 (1980) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. The transport glider. McGill Alexander. Abstract.

  8. Splice site, frameshift, and chimeric GFAP mutations in Alexander disease

    NARCIS (Netherlands)

    Flint, D.; Li, R.; Webster, L.S.; Naidu, S.; Kolodny, E.; Percy, A.; van der Knaap, M.S.; Powers, J.M.; Mantovani, J.F.; Ekstein, J.; Goldman, J.E.; Messing, A.; Brenner, M.

    2012-01-01

    Alexander disease (AxD) is a usually fatal astrogliopathy primarily caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP), an intermediate filament protein expressed in astrocytes. We describe three patients with unique characteristics, and whose mutations have implications

  9. The alexander surgical technique for the treatment of severe burns.

    Science.gov (United States)

    Gasperoni, M; Neri, R; Carboni, A; Purpura, V; Morselli, P G; Melandri, D

    2016-12-31

    The extensive loss of skin in burned patients is a critical clinical condition, and the choice of an effective technique to cover and protect the damaged area has always been a challenge in the surgical field. Despite its wide clinical use, there is little data in the literature on using the Alexander technique to treat severe burns, while several studies have focused on alternative approaches. The present study aims to evaluate the effectiveness of the Alexander surgical technique on 117 patients with severe burns. The characteristics of the burned patients, factors related to etiology of burns as well as adverse prognostic factors and their incidence in discharged versus deceased patients were also taken into account. Finally, a comparison is made with an alternative surgical procedure described in the literature. Our results show a satisfactory level of survival for patients with severe burns surgically treated with the Alexander technique, accounting for 63% of all clinical cases reported here. This treatment is also less expensive and more rapid than the alternative approach we compared it with. The Alexander technique is a lifesaving method for the treatment of severe burns that provides a satisfactory chance of survival at lower cost than the alternative surgical procedure examined.

  10. Krahv Alexander von Keyserling / Sirje Kivimäe

    Index Scriptorium Estoniae

    Kivimäe, Sirje, 1947-

    2002-01-01

    Alexander Friedrich Michael Lebrecht Arthur Nicolaus James von Keyserlingi (1815-1891) elust ja teaduslikest ekspeditsioonidest Venemaal ning tegevusest Eestis Raikküla mõisnikuna, loodusteadlasena, Eestimaa rüütelkonna peamehena, eesti talupoegade olukorra parandajana, Tartu õpperingkonna kuraatorina, maanõunikuna, tema pereelust ja lastest

  11. Goethe und Alexander von Humboldt - Bau und Geschichte der Erde

    Directory of Open Access Journals (Sweden)

    Wolf von Engelhardt

    2001-10-01

    Full Text Available Article in German, Abstracts in English and German. An account is given on Goethe's criticism of Alexander von Humboldt's writings: "Ueber den Bau und die Wirkungsart der Vulkane in den verschiedenen Erdstrichen" (Berlin 1823 und "Fragmens de géologie et de climatologie asiatique" (Paris 1831.

  12. Tradition, authority and dialogue: Arendt and Alexander on education

    Directory of Open Access Journals (Sweden)

    Itay Snir

    2018-01-01

    Full Text Available In this paper I discuss two attempts to challenge mainstream liberal education, by Hannah Arendt and by contemporary Israeli philosopher Hanan Alexander. Arendt and Alexander both identify problems in liberal-secular modern politics and present alternatives based on reconnecting politics and education to tradition. I analyze their positions and bring them into a dialogue that suggests a complex conception of education that avoids many of the pitfalls of modern liberal thought. First, I outline Arendt and Alexander’s educational views and discuss their similarities, arguing that both may be understood as opposed to the modern attempt to adopt a «view from nowhere» at the world. Next, I suggest that Alexander’s view may benefit from adopting Arendt’s conceptions of tradition and authority. In the consecutive section, I argue that Alexander sheds light on significant problems in Arendt’s approach to education, problems his understanding of critical dialogue can help solve. The succeeding section joins the two views together to form an approach I call «critical traditionalism», and examines it against prevailing approaches to political education. I conclude by pointing to an important point overlooked by both Arendt and Alexander, namely the need for internal political struggle within each tradition.

  13. Bemerkungen zu Alexander von Humboldts Russland-Tagebuch

    Directory of Open Access Journals (Sweden)

    Petra Werner

    2008-04-01

    Full Text Available Article in German, Abstracts in English and GermanIn this study the fragment of Alexander von Humboldt’s Siberian personal diary of 1829 is introduced. The evaluation is focussed on Humboldt’s remarks about mineral resources, especially gold and diamonds. Also mentioned are results which Humboldt recorded about geographical, botanical, meteorological, zoological and ethnological questions.

  14. Nitric oxide mediates glial-induced neurodegeneration in Alexander disease.

    Science.gov (United States)

    Wang, Liqun; Hagemann, Tracy L; Kalwa, Hermann; Michel, Thomas; Messing, Albee; Feany, Mel B

    2015-11-26

    Glia play critical roles in maintaining the structure and function of the nervous system; however, the specific contribution that astroglia make to neurodegeneration in human disease states remains largely undefined. Here we use Alexander disease, a serious degenerative neurological disorder caused by astrocyte dysfunction, to identify glial-derived NO as a signalling molecule triggering astrocyte-mediated neuronal degeneration. We further find that NO acts through cGMP signalling in neurons to promote cell death. Glial cells themselves also degenerate, via the DNA damage response and p53. Our findings thus define a specific mechanism for glial-induced non-cell autonomous neuronal cell death, and identify a potential therapeutic target for reducing cellular toxicity in Alexander disease, and possibly other neurodegenerative disorders with glial dysfunction.

  15. Alexander's law during high-acceleration head rotations in humans.

    Science.gov (United States)

    Anagnostou, Evangelos; Heimberger, Joachim; Sklavos, Sokratis; Anastasopoulos, Dimitri

    2011-03-30

    Alexander's law states that the amplitude of the spontaneous nystagmus grows with increasing gaze in the direction of the fast phase. Using the search-coil method we employed head impulses at various eye-in-orbit azimuth angles to test (i) whether the normal vestibulo-ocular reflex (VOR) in the behaviorally relevant high-frequency range has intrinsic properties that could account for Alexander's law and (ii) whether such properties can also be shown in patients with unilateral vestibulopathy. We showed that the gain of the VOR remained unaffected by eye-in-orbit position in contols and in patients, both on ipsilesional and contralesional stimuli. These findings suggest that eye-in-orbit position does not directly modulate the activity in VOR pathways, neither during unbalanced but reciprocal (in controls), nor during unbalanced and nonreciprocal natural vestibular stimulation (in patients).

  16. A Study of Combined Arms Warfare by Alexander the Great.

    Science.gov (United States)

    1998-06-05

    Arms Warfare by Alexander the Great Approved by: ^§FC ^ohn T. Broom, Ph.D. ^c^. Thesis Committee Chairman y v^X^; ■-. ■SA: Gary J. Bjorge ...research. Dr. Bjorge and LTC Clay have provided technical advice and copy editing for much of this thesis. Special acknowledgment is due LTC David...objective to destroy or disrupt the enemy forces. Additionally, ancient armies did not have the communication ability that the modern army possess

  17. Modelled on Archigenes 'theiotatos': Alexander of Tralles and his Use of Natural Remedies ('physika')

    OpenAIRE

    Bouras-Vallianatos, Petros

    2016-01-01

    In contrast to other Late Antique medical authors, Alexander of Tralles uses the epithet theiotatos (most divine) when referring to Archigenes. This appellation becomes even more significant if one considers that Alexander otherwise only applies it to Hippocrates and Galen. Since the majority of Alexander’s mentions of Archigenes stress his recommendation of popular healing practices, which most medical authors excluded from their work, I argue that for Alexander Archigenes was a model of a w...

  18. Provintsist pärit IT-mõtleja / Alexander Galitsky ; interv. Viktoria Korpan

    Index Scriptorium Estoniae

    Galitsky, Alexander

    2005-01-01

    Venemaa tuntumaid info- ja kõrgtehnoloogiavaldkonna spetsialiste infotehnoloogiast ja selle erinevatest võimalustest, tehnoloogia lahendustest ning avastustest, turvaprobleemidest. Lisa: Alexander Galitsky

  19. Body and Soul: The Natural Affinity Between the Alexander Technique and the Stanislavsky Method.

    Science.gov (United States)

    Richmond, Phyllis

    1996-01-01

    Describes the compatibility between the Alexander Technique and the Stanislavsky Method. Explains the basic concept behind both acting methods. Presents ideas for incorporating both methods in classes. (PA)

  20. Alexander technique and Feldenkrais method: a critical overview.

    Science.gov (United States)

    Jain, Sanjiv; Janssen, Kristy; DeCelle, Sharon

    2004-11-01

    This article develops an overall better understanding of the Alexander technique and Feldenkrais method. Initially, a brief history is provided to lay the groundwork for the development of these techniques. A description of the techniques, training requirements, and mechanism of action follows. Indications, contraindications, and patient selection are discussed. This article reviews and identifies what research has been completed and what areas need further investigation. Overall, the goal is to establish a guide to aid in determining who may benefit from these techniques and outcomes to expect when using these techniques.

  1. Alexander Georg Supan – v Sloveniji spregledan geograf slovenskega rodu

    Directory of Open Access Journals (Sweden)

    Dejan Cigale

    2016-12-01

    Full Text Available Paper presents life and work of Alexander Supan, geographer of Slovenian origin, and his influence on global and Slovenian geography. He was one of the more important geographers of the second half of the 19th and at the beginning of the 20th century. His scientific work took place, in contrast to geographers who were then working in present-day Slovenian territory, in accordance with contemporary geographic approaches. He built his career abroad, but he started it in Ljubljana. Because of that and because of his origin, we can consider him one of the more important links in the history of modern geography in Slovenian territory.

  2. Reluctant genius Alexander Graham Bell and the passion for invention

    CERN Document Server

    Gray, Charlotte

    2011-01-01

    The popular image of Alexander Graham Bell is that of an elderly American patriarch, memorable only for his paunch, his Santa Claus beard, and the invention of the telephone. In this magisterial reassessment based on thorough new research, acclaimed biographer Charlotte Gray reveals Bell's wide-ranging passion for invention and delves into the private life that supported his genius. The child of a speech therapist and a deaf mother, and possessed of superbly acute hearing, Bell developed an early interest in sound. His understanding of how sound waves might relate to electrical waves enabled h

  3. Alexander disease - astrogliopathy considered as leukodystrophy - experience of an institution.

    Science.gov (United States)

    Mierzewska, Hanna; Mierzewska-Schmidt, Magdalena; Salomons, Gajja S; Dudzińska, Magdalena; Szczepanik, Elżbieta

    2016-01-01

    Alexander Disease (ALXDRD) is an autosomal dominant leukodystrophy caused by mutation in one allele of GFAP gene, encoding glial fibrillary acidic protein (GFAP). Most cases occur due to de novo. There are three clinical subtypes of ALXDRD: infantile, juvenile and adult form, but congenital form is also outlined. The disease's spectrum comprises of macrocephaly, progressive pyramidal signs, and seizures in congenital and infantile subtypes. Neuropathologically are enormous number of Rosenthal fibers (RF) mainly around vessels, in subependymal and subpial regions are found. The diagnosis is based on the typical findings on MRI: diffuse white mater lesions with frontal regions preponderance and possibly on the detection of the gene mutation. Here we present six Polish children affected of Alexander disease with congenital (1), infantile (4) and juvenile (1) form. Five of them were previously misdiagnosed as cerebral palsy or unspecific developmental delay; two patients had MRI because of another suspicion, before specific diagnosis was established. Molecular analysis performed in four cases confirmed mutations of GFAP gene; all mutation were de novo. The role of astroglia in brain is shortly reviewed.

  4. Mapping of protein-protein interaction network of Alexander disease.

    Science.gov (United States)

    Saxena, A K; Saxena, V L; Dixit, S

    2016-05-30

    Alexander disease (ALXD) is slowly progressive neurodegenerative disorder which affects white matter of the central nervous system. The main cause of disorder is mutation in GFAP gene and mutation in some other genes were also reported. This study was aimed at getting a better insight into ALXD pathogenesis and identifying the important functional and highly interconnected nodes in human protein interaction network, identifying the important sub-networks in the system could be helpful in understanding the underlying molecular mechanism. The topological analysis of human protein interaction network strategy to identify highly interconnected sub-network modules from which six proteins are found i.e. GFAP, PLEC, CRYAB, NDUFV1, CASP3 and MAPK14 plays important role in disease. Further, the enrichment analysis of interaction network identifies crucial pathways in which most of the diseased proteins overlaps. Through system biology approach, the undirected human protein interaction network of ALXD is buildup with the help of Cytoscape tool and its various plugins helps to investigate network further. The systematic approach suggests the finding of previously known proteins, GFAP, PLEC, CRYAB, NDUFV1, CASP3 and MAPK14 can be used as a drug targets and potential treatment discovered also enrichment analysis will provide guidance for the future study on Alexander disease.

  5. [An atypical presentation of Infantile Alexander disease lacking macrocephaly].

    Science.gov (United States)

    Esmer, Carmen; Villegas-Aguilera, Miguel; Morales-Ibarra, Juan José; Bravo-Oro, Antonio

    Alexander disease is a rare form of leukodystrophy that involves mainly astrocytes; it is inherited in an autosomal recessive manner and occurs by mutations in the GFAP gene, located on chromosome 17q21. It can occur at any age and its infantile form is characterized by macrocephaly, seizures, severe motor and cognitive delay, and progressive spasticity or ataxia. An 8-month-old female was evaluated with a history of neurodevelopmental delay and unprovoked focal motor seizures. Physical examination showed normal head circumference, increased motor responses to tactile and noise stimuli, pyramidal signs and no visceromegalies. Widespread hypodense white matter was found on magnetic resonance and lumbar puncture showed hyperproteinorrachia. Krabbe disease was ruled out by enzymatic assay and gene sequencing of GALC. In the reassessment of the case, abnormalities in neuroimaging lead to suspicion of Alexander disease, and GFAP gene sequencing reported a pathogenic mutation in exon 4 c.716G>A, which caused a change of arginine to histidine at position 239 of the protein (p.Arg239His). The radiographic signs observed in the resonance were decisive for the diagnosis, later confirmed by molecular study. It is important to consider that certain mutations are not associated with macrocephaly, which may cause delay in diagnosis. Copyright © 2016 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

  6. Alexander disease with periventricular calcification: a novel mutation of the GFAP gene

    NARCIS (Netherlands)

    Jefferson, Rosalind J.; Absoud, Michael; Jain, Rakesh; Livingston, John H.; van der Knaap, Marjo S.; Jayawant, Sandeep

    2010-01-01

    Alexander disease is a rare neurodegenerative leucoencephalopathy caused by de novo mutations in the GFAP gene. Infantile, juvenile, and adult subtypes have been described and the clinical and radiological phenotypes are broad. Here we report on a single case of juvenile-onset Alexander disease

  7. 76 FR 28226 - Ndahendekire Barbara v. African Shipping; Njoroge Muhia; Alco Logistics, Llc; Brenda Alexander...

    Science.gov (United States)

    2011-05-16

    ... Ndahendekire Barbara v. African Shipping; Njoroge Muhia; Alco Logistics, Llc; Brenda Alexander; and AIR 7 Seas... ``Complainant,'' against African Shipping; Njoroge Muhia, ALCO Logistics, LLC; Brenda Alexander; and Air 7 Seas Transport Logistics, Inc.; hereinafter ``Respondents''. Complainant asserts that she is acting agent for...

  8. Whole rice bran for beef heifers raised on alexander grass pasture

    Directory of Open Access Journals (Sweden)

    P. R. Salvador

    2016-09-01

    Full Text Available The objective of this study was to evaluate the development of beef heifers exclusively fed alexander grass (Urochloa plantaginea (Link Hitch or alexander grass and whole rice meal as supplement offered from Monday to Friday. The experimental design was completely randomized, with repeated measures over time, and consisted of two treatments and three replications of area. Heifers receiving whole rice meal exhibited higher average daily gain after day 42 of pasture use and a 21% higher body weight at the end of the grazing period. The stocking rate, weight gain per area, hip height, weight-height ratio, and body condition score were similar for heifers exclusively fed alexander grass and alexander grass plus rice bran. Beef heifers raised exclusively on alexander grass from 15 to 18 months of age reached adequate body development, reproductive tract score (4.22 points and pelvic area (206.3 cm² to be bred at 18-20 months of age.

  9. Ascensión al Teide de Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Thomas Heyd

    2015-05-01

    Full Text Available Zusammenfassung In dieser kurzen Abhandlung wird dargelegt, dass Alexander von Humboldt durch die Besteigung des Teide eine integrierende Perspektive erwerben konnte, die ihm als Rahmen wissenschaftlicher Kommunikation dienen würde um die Vielzahl der Daten, welche er sich vorgenommen hatte auf der Insel zu sammeln, zu vereinen. Darüber hinaus wird ihm dieser Rahmen von hier an auch dazu dienen, um den unzähligen und verschiedenartigen Informationen, die er in den verbleibenden fünf Reisejahren sammeln würde, einen einheitlichen Sinn zu geben. Um die Blickrichtung von Humboldts Besuch auf Teneriffa darzulegen, untersuche ich seinen Bericht über die Besteigung des Teide unter der Annahme, dass er den Aufbau epischer Reisen und Pilgerfahrten hat. Summary In this brief essay I propose that, with the ascent of the Teide, Alexander von Humboldt was able to acquire an integrating perspective that served him as a framework for scientific communication to unify the multitude of data that he had set out to collect during his brief stay on the island. Moreover, thereafter this framework would also serve him to give a unified sense to the countless and diverse kinds of information that he could collect during the remaining five years of travel. To bring out the focus of Humboldt’s visit to Tenerife, I analyse his account of the ascent of the Teide by assuming that it is structured in the manner of the stories of epic journeys and pilgrimages. Resumen En este breve ensayo propongo que en la ascensión al Teide Alexander von Humboldt pudo adquirir una perspectiva integral, que le sirvió como marco de comunicación científica para aunar la multitud de datos que se había dispuesto a recoger en su breve estancia en la isla. Más aun, de ahí en adelante este marco además le serviría para darle sentido de conjunto a las incontables y diversas informaciones que recogería en los restantes cinco años de viaje. Para poner en evidencia el enfoque de la

  10. Disorders of Astrocytes: Alexander Disease as a Model.

    Science.gov (United States)

    Olabarria, Markel; Goldman, James E

    2017-01-24

    Astrocytes undergo important phenotypic changes in many neurological disorders, including strokes, trauma, inflammatory diseases, infectious diseases, and neurodegenerative diseases. We have been studying the astrocytes of Alexander disease (AxD), which is caused by heterozygous mutations in the GFAP gene, which is the gene that encodes the major astrocyte intermediate filament protein. AxD is a primary astrocyte disease because GFAP expression is specific to astrocytes in the central nervous system (CNS). The accumulation of extremely large amounts of GFAP causes many molecular changes in astrocytes, including proteasome inhibition, stress kinase activation, mechanistic target of rapamycin (mTOR) activation, loss of glutamate and potassium buffering capacity, loss of astrocyte coupling, and changes in cell morphology. Many of these changes appear to be common to astrocyte reactions in other neurological disorders. Using AxD to illuminate common mechanisms, we discuss the molecular pathology of AxD astrocytes and compare that to astrocyte pathology in other disorders.

  11. The Astronomer Alexander I. Postoiev (1900-1976)

    Science.gov (United States)

    Dos Santos, P. M.; Matsuura, O. T.

    This is a biographical note on the life of Dr Alexander I. Postoiev, a victim of Stalin's purge of Soviet astronomers in 1936-1937 (McCutcheon, 1985). Along with his family, he left the Soviet Union in 1943, and lived in Germany as a refugee and "displaced person" until 1952, when he moved to Brazil. Then he started the second part of his professional career. Thanks to his efforts the Astronomical and Geophysical Institute (IAG) from the University of Sao Paulo (USP) was involved, for the first time, in programme of international cooperation, thus contributing to the institutional consolidation of IAG/USP as a leading centre of astronomical research and teaching today in Brazil.

  12. Alexander William Bickerton: New Zealand’s First Astrophysicist?

    Science.gov (United States)

    Gilmore, Gerard F.

    Alexander Bickerton (1842-1929) is of interest to the student of New Zealand astronomical history in several ways. He was the first Professor at Canterbury University College, and had a significant effect on the early development of the University; he was a prominent and successful teacher, Ernest Rutherford being his most famous student; he was a social activist in Victorian Christchurch, eventually establishing a small commune; and he was the originator of the stellar collision theory of novae and other astronomical phenomena. This chapter, which is a slightly revised version of Gilmore (Southern Stars, 29, 87-108, 1982), provides a summary of Bickerton's life and theories, and a bibliography for further reading.

  13. Hypertextuality in the Alexander von Humboldt Digital Library

    Directory of Open Access Journals (Sweden)

    Detlev Doherr

    2016-04-01

    Full Text Available To do justice to the legacy of Alexander von Humboldt, a 19th century German scientist and explorer an information and knowledge management system is required to preserve the author's original intent and promote an awareness of all his relevant works. Although all of Humboldt's works can be found on the internet as digitized papers, the complexity and internal interconnectivity of the writings is not very transparent. Humboldt's concepts of interaction cannot be adequately represented only by digitized papers or scanned documents. The Humboldt Portal is an attempt to create a new generation of digital libraries, providing a new form of interaction and synthesis between humanistic texts and scientific observation. The digital version of his documents supplies dynamic links to sources, maps, images, graphs and relevant texts in accordance with his visions, because "everything is interconnectedness".

  14. In Memoru of Alexander M. Poniatoff (1892 – 1980

    Directory of Open Access Journals (Sweden)

    V. P. Samokhin

    2017-01-01

    Full Text Available A brief overview of the life and works of the main achievements of Alexander M. Poniatoff is given. He was an outstanding engineer and founder of AMPEX – American company that won the world recognition in the field of magnetic recording of signals. The description of life AM Poniatowa in childhood and youth, his education in Russia and Germany, in the imperial service, and the "white" army, emigration and employment in the United States, including the establishment of the company AMPEX details and interesting facts from its progressive development into a global leader audio and video equipment. The AMPEX engineers created the world's first tape recorders and videotape recorders of professional quality, which contributed to the radical improvement of the radio and television broadcasting technologies. Twelve development AMPEX awarded prizes Emmy Awards, awarded by the American Academy of Television Arts & Sciences and the four recognized as the best in the category Monitor Awards International Society of television production.

  15. Roger Bacon in der Sicht Alexander von Humboldts

    Directory of Open Access Journals (Sweden)

    Tom Müller

    2008-10-01

    Full Text Available Articel in german, abstracts in englisch, german and español In his model of the six epochs of the history of science, Alexander von Humboldt sees scarcely any lights able to break through the occidental darkness in the time between the scientific prime of the arabic world and the expeditions of Columbus. The most prominent of these few pioneers to Humboldt is the fransciscan monc Roger Bacon who excelled in almost all disciplines and emphasized on the unity of the sciences. Humboldt honors the Englishman with detailed examinations of his Opus maius in Kosmos and also in his popular speeches in the Berlin Singakademie as well as in the examen critique on the history of geography of the New World.

  16. Effects of Alexander Technique training experience on gait behavior in older adults.

    Science.gov (United States)

    O'Neill, Matthew M; Anderson, David I; Allen, Diane D; Ross, Christopher; Hamel, Kate A

    2015-07-01

    Heightened fall risk, potentially caused by aging-related changes in gait, is a serious health issue faced by older adults. The Alexander Technique is thought to improve balance and motor function; however, the technique's effect on gait has not been studied. The purpose of this study was to examine the effect of Alexander Technique training in older adults on the temporospatial characteristics of gait and medio-lateral center of mass displacement during fast and comfortably paced over-ground walking. Six licensed Alexander Technique teachers and seven controls between the ages of 60 and 75 years of age participated in the study. Alexander Technique teachers exhibited a reduction in medio-lateral center of mass displacement during fast paced walking compared to comfortably paced walking that was not present in controls. Due to this difference Alexander Technique teachers displayed a smaller medio-lateral Center of Mass displacement compared to controls during fast paced walking. Alexander Technique teachers also demonstrated significantly smaller stride width and lower gait timing variability compared to controls. These findings, which suggest superior control of dynamic stability during gait and potentially reduced fall risk in Alexander Technique teachers, warrant further study. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Alexander disease with periventricular calcification: a novel mutation of the GFAP gene.

    Science.gov (United States)

    Jefferson, Rosalind J; Absoud, Michael; Jain, Rakesh; Livingston, John H; VAN DER Knaap, Marjo S; Jayawant, Sandeep

    2010-12-01

    Alexander disease is a rare neurodegenerative leucoencephalopathy caused by de novo mutations in the GFAP gene. Infantile, juvenile, and adult subtypes have been described and the clinical and radiological phenotypes are broad. Here we report on a single case of juvenile-onset Alexander disease associated with a novel frameshift mutation in the GFAP gene. The 8-year-old male patient had a relatively mild clinical phenotype characterized by dystonia, intermittent episodes of raised intracranial pressure, and characteristic radiological changes. He also presented with the additional and to our knowledge previously unreported, neuroimaging finding of periventricular calcification. We postulate that in children with leucoencephalopathy and periventricular calcification of undetermined aetiology, the diagnosis of Alexander disease should be considered. If the magnetic resonance imaging findings are compatible with Alexander disease, then DNA analysis of the GFAP gene should be performed even if the full criteria for a neuroradiological diagnosis are not met.

  18. Alexander Theodor von Middendorff ja sihikindla hobusearetuse algus Eestis / Erki Tammiksaar

    Index Scriptorium Estoniae

    Tammiksaar, Erki, 1969-

    2012-01-01

    Alexander Theodor von Middendorffi tegevusest hobuse füsioloogia ning anatoomia uurijana ja Eesti maatõugu hobuse aretussuundade seadjana Tori hobusekasvanduses Liivimaa Üldkasulik ja Ökonoomiline Sotsieteedi presidendina

  19. The Berlin tradition in Chicago: Franz Alexander and the Chicago Institute for Psychoanalysis.

    Science.gov (United States)

    Schmidt, Erika S

    2010-01-01

    Freud considered Franz Alexander, the first graduate of the Berlin Psychoanalytic Institute and an assistant in the Berlin Polyclinic, to be "one of our strongest hopes for the future." Alexander went on to become the first director of the Chicago Institute for Psychoanalysis in 1932 and modeled some of the Chicago Institute's mission on his Berlin experiences. He was also a researcher in psychosomatic medicine, a prolific writer about psychoanalysis and prominent in psychoanalytic organizations. As he proposed modifications in psychoanalytic technique, he became a controversial figure, especially in the elaboration of his ideas about brief therapy and the corrective emotional experience. This paper puts Alexander's achievements in historical context, draws connections between the Berlin and Chicago Institutes and suggests that, despite his quarrels with traditional psychoanalysis, Alexander's legacy may be in his attitude towards psychoanalysis, characterized by a commitment to scientific study, a willingness to experiment, and a conviction about the role of psychoanalysis within the larger culture.

  20. THE IMAGE OF THE TSAR ABANDONING HIS THRONE IN ALEXANDER PUSHKIN'S POETRY

    Directory of Open Access Journals (Sweden)

    Lebedeva E. S.

    2008-11-01

    Full Text Available The article analyses the image of the Tzar, who abandoned his family name, throne and crown and hid to repent his sins, created by Alexander Pushkin in his poems "Angelo" and "Roderick".

  1. 76 FR 54800 - Sandy Alexander, Clifton, NJ; Notice of Negative Determination on Reconsideration

    Science.gov (United States)

    2011-09-02

    ... Application for Reconsideration for the workers and former workers of Sandy Alexander, Clifton, New Jersey... facts not previously considered; or (3) if in the opinion of the Certifying Officer, a mis...

  2. A Russian Man on Horseback: The Rise of General Alexander Lebed

    National Research Council Canada - National Science Library

    O'Malley, Kevin

    1997-01-01

    General Alexander Lebed burst upon the Russian political scene like a man on horseback, promising to restore order out of chaos, crack down on crime and corruption, and resurrect Russian nationalism...

  3. The Alexander Technique and musicians: a systematic review of controlled trials

    National Research Council Canada - National Science Library

    Klein, Sabine D; Bayard, Claudine; Wolf, Ursula

    2014-01-01

    .... Therefore, some use the Alexander Technique (AT), a psycho-physical method that helps to release unnecessary muscle tension and re-educates non-beneficial movement patterns through intentional inhibition of unwanted habitual behaviours...

  4. Educating with the hands: working on the body/self in Alexander Technique

    National Research Council Canada - National Science Library

    Tarr, Jennifer

    Traditionally, forms of body work such as Alexander Technique have been excluded from mainstream biomedicine and healthcare, despite attempts by practitioners to have the work accepted within the medical community...

  5. The effect of Alexander technique training program: A qualitative study of ordinary behavior application.

    Science.gov (United States)

    Kim, Soo-Yeon; Baek, Soon Gi

    2014-12-01

    The purpose of this study was to configure and apply the Alexander technique training program and assess the effect of program through physical, emotional and behavioral aspects. To achieve the research aims, qualitative research method had been conducted, subjecting 8 people, who were participating in Alexander Technique training program for this study. The study used focus group interview method for collecting date and employed for the interview method by mixing the semi-structured and unstructured questionnaire. The results were followings. First, one could develop body awareness and body consciousness through experiencing lived bodily sensation. Second, from Alexander Technique training program, people experienced psycho & physical's equilibrium. Third, one could change not only the manner of use of body but also the attitude to the life from conscious attention to daily ordinary movement. The results provided empirical evidence of Alexander Technique training program's functions in terms of physical, emotional and behavioral aspect through the process of consciousness control from lived body education.

  6. Clinical experience in late antiquity: Alexander of Tralles and the therapy of epilepsy.

    Science.gov (United States)

    Bouras-Vallianatos, Petros

    2014-07-01

    Alexander of Tralles, writing in the late sixth century, combined his wide-ranging practical knowledge with earlier medical theories. This article shows how clinical experience is used in Alexander's works by concentrating on his therapeutic advice on epilepsy and, in particular, on pharmacology and the group of so-called natural remedies. I argue that clinical testing is used not only for the introduction of new medicines but also as an instrument for checking the therapeutic effect of popular healing practices. On another level, this article discusses Alexander's role as the author of a medical compendium; it suggests that by marking the cases of clinical testing with a set of recurrent expressions, Alexander leads his audience to reflect on his medical authority and personal contribution.

  7. Siim Nestor soovitab : Ben Frost ja Alexander Robotnik Eclectical / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2007-01-01

    Austraalia muusik ja helilooja Ben Frost projektiga "6 guitars" esinemas festivali Eclectica raames 6. sept. Tartu klubis Rock ja Roll ja itaalia diskor Alexander Robotnik 7. sept. klubis Trehv, esinejatest

  8. Alexander disease as a cause of nocturnal vomiting in a 7-year-old girl

    Energy Technology Data Exchange (ETDEWEB)

    Niinikoski, Harri [University of Turku, Department of Paediatrics, Turku (Finland); Haataja, Leena [University of Turku, Department of Paediatrics, Turku (Finland); University of Turku, Department of Pediatric Neurology, Turku (Finland); Brander, Antti [University of Tampere, Department of Radiology, Tampere (Finland); Valanne, Leena [University of Helsinki, Department of Radiology, Helsinki (Finland); Blaser, Susan [Hospital for Sick Children, Department of Radiology, Toronto (Canada)

    2009-08-15

    Alexander disease is a rare form of leukodystrophy with a highly variable clinical course. Occasionally night-time nausea and vomiting are the first symptoms of juvenile Alexander disease. A 7-year-old girl had recurrent night-time vomiting and her growth and weight gain had deteriorated after her sixth birthday. Cranial MRI demonstrated two small, symmetrical focal areas of abnormally high signal intensity in the dorsal medulla oblongata on T2-W and FLAIR images. These were suggestive of juvenile Alexander disease, and subsequent sequencing of the glial fibrillary acidic protein (GFAP) gene revealed a heterogeneous missense mutation in the GFAP gene in exon 6. Alexander disease should be considered in young patients with atypical anorexia nervosa-type symptoms. (orig.)

  9. La pasión de Alexander Crichton

    Directory of Open Access Journals (Sweden)

    Matusevich, Daniel

    2015-12-01

    Full Text Available Alexander Crichton was born in Edinburgh in 1763; he graduated from Leyden University and travelled through Berlín, Paris, Stuttgart, Prague and Gotinga to perfect his knowledge in medicine while he establish a deep connection between the social media and the culture of those places. On 1798 he published An inquiry into the nature and origin of Mental Derangement, the only book he wrote dedicated to madness. In this paper we review some questions referred to the general method that the author applies, his contributions to the semiotics of the mind and to the analysis of the process of aging and the function of the attention; we also take a look to his conception of the world of passions and of madness, who influenced Philippe Pinel and Dominique Esquirol and also constitute a cornerstone in the birth of psychiatry.Alexander Crichton, nació en Edimburgo en 1763, se graduó en la Universidad de Leyden y completó su formación médica en Berlín, Paris, Stuttgart, Praga y Gotinga, vinculándose estrechamente con el ambiente social y cultural de esos prestigiosos centros europeos. En el año 1798 publicó An Inquiry into the nature and origin of Mental Derangement (Investigación sobre la naturaleza y el origen del trastorno mental, única obra de su autoría dedicada a la locura. En este artículo se analizan algunas cuestiones referidas al método general que aplica el autor para la concepción de su obra, sus contribuciones a la semiología de la mente, al análisis del proceso de envejecimiento y a la función de la atención, para detenernos, finalmente, en su conceptuación del mundo de las pasiones y de la locura que fueron retomadas por otros autores como Philippe Pinel y Dominique Esquirol, y que constituyeron un antecedente fundamental en el nacimiento de la psiquiatría.

  10. [An infant form of Alexander disease (a clinical case and literature review)].

    Science.gov (United States)

    Vasin, R A; Krasnikov, M A; Vasina, S V

    We present a case of the infant form of Alexander disease. The case uniqueness is that the patient's examination had been started at the preclinical stage and was continued during the manifestation and fastigium of disease. We present rare images obtained during neurosonography at the preclinical stage of the disease as well as the unique findings of MRI studies. The MRI findings at disease onset and 3 years later indicate that the infant form of Alexander disease is characterized by clinical stages.

  11. History and Pre-History of the Alexander von Humboldt Foundation

    OpenAIRE

    D. Platikanov

    2014-01-01

    In this paper a short review of the history of Alexander von Humboldt Foundation, Bonn - Bad Godesberg, Germany, on the occasion of its 60th anniversary is presented. This outstanding German foundation is actually the third one with the same name. Earlier two other Alexander von Humboldt Foundations consequently existed and they consist its pre-history, which is also shortly reviewed. The establishment of the present Foundation in 1953, its development and growth, its activities, information ...

  12. An exploration of the potential contributions of the Alexander Technique to piano pedagogy

    OpenAIRE

    Santiago, Patricia Furst

    2004-01-01

    This study investigates to what extent a specific body-mind technique - the Alexander Technique - helps young Brazilian piano pupils to improve their approach to learning and their perforinance. The study took as its starting point a review of the literature on the Alexander Technique and on piano pedagogy, written in English and Portuguese, as well as a range of related and complementary literatures. Data was collected using several methods, including an experimental strategy with random all...

  13. THE BISHOP OF NOLINSK ALEXANDER (MALININ: FOGOTTEN CONFESSOR OF THE FAITH

    Directory of Open Access Journals (Sweden)

    A. KOSTRYUKOV

    2014-04-01

    Full Text Available The article describes life of Vyatka diocese vicar bishop of Nolinsk Alexander (Malinin. Currently fates of hierarch who was ordained in 1920–1930 isn’t investigated. One of the problems in biography of bishop Alexander is mistake of Metropolitan Elevfery (Bogoyavlensky. He called this hierarch John in his book “A week in Patriarhiya”. As a result, bishop Alexander was mentioned twice in all directories — under his own name and under name “bishop John of Glazov”. Life of bishop Alexander was almost unknown. But his biography was managed to establish. According to an investigative case he was arrested two weeks later, after bishop’s ordination in the night from 10-th to 11-th of December. He was arrested because he said reckless statement during his ordination. In his speech he spoke about persecution of the Church and bishop’ arrests. This speech was pronounced in the in the presence of foreign hierarch — Elevfery (Bogoyavlensky. Bishop Alexander was blamed of trying to transmit information abroad about persecution of the Orthodox Church. He was senteneed to three years in camps. He died when he arrived of the place. In the article is concluded that we should approach to source (such as “A week in Patriarhiya” with precautions. Moreover, author pay attention that until recently name of bishop Alexander absented in passionless of casualties of Communist repressions. So, we must explore feats of Martyrs and Russian confessors more actively.

  14. The life and music of Alexander Scriabin: megalomania revisited.

    Science.gov (United States)

    Starcevic, Vladan

    2012-02-01

    To shed more light on the relationship between the grandiosity of the Russian composer Alexander Scriabin (1872-1915) and his creative output, and discuss its implications for psychopathology. Scriabin was a highly original composer, who brought innovations to the idiom of music. He firmly believed that music and philosophy were inseparable and that music was only a vehicle for expressing ideas and emotional states. As Scriabin was getting more preoccupied with mysticism and as he was developing a belief that his mission was to save the world through his art, his music became more esoteric. Over the last five years of his life, he composed relatively little, as he was working on a supergrandiose project that he never completed. Scriabin's grandiosity, which had delusional qualities, might have diminished his creativity towards the end of his life and contributed to his destructive fantasies. All along, his social façade was well preserved and he was not noted to exhibit overt psychotic behaviour, suggesting an encapsulated delusional megalomania. The implications of megalomania, especially in creative or otherwise influential individuals, are briefly discussed.

  15. Сharitable activities of Alexander Andreevich Zhelobovskiy

    Directory of Open Access Journals (Sweden)

    Zhukova Lekkha

    2014-08-01

    Full Text Available The article is devoted to charitable works of Alexander Andreevich Zhelobovskiy, and his participation in various charitable General communities. He was the first Russian protopresbyter of the military clergy and did much to shape the staff of experienced and knowledgeable priests who actively worked not only to ensure religious worship in the army, but also for the Patriotic upbringing of soldiers. In these purposes and based on personal beliefs, Zhelobovskiy set up several scholarships for talented students studying in the Theological Academies. In addition, Zhelobovskiy made a great contribution to provision of pensions little-haves elderly priests, as well as to their widows and orphans. To help the poor, by Zhelobovskiy’s own money was built candle factory, profit from which amounted to “orphan’s capital”. The scope of the paper includes the activities of the first Russian protopresbyter of the military clergy on the planting and construction of military and regimental churches in various cities. Until 1901 military churches were required to actively participate in the search of philanthropists. One of the themes of this article is the charity organization and own philanthropy activities Zhelobovskiy during the Russo-Japanese war. Special attention is paid to the contribution of Zhelobovskiy in the case of charity on his «small Motherland». Where Zhelobovskiy not only built the temple, but also established the hospice and also did much to Belozersky spiritual school.

  16. Alexander Forbes, Walter Cannon, and science-based literature.

    Science.gov (United States)

    Garson, Justin

    2013-01-01

    The Harvard physiologists Alexander Forbes (1882-1965) and Walter Bradford Cannon (1871-1945) had an enormous impact on the physiology and neuroscience of the twentieth century. In addition to their voluminous scientific output, they also used literature to reflect on the nature of science itself and its social significance. Forbes wrote a novel, The Radio Gunner, a literary memoir, Quest for a Northern Air Route, and several short stories. Cannon, in addition to several books of popular science, wrote a literary memoir in the last year of his life, The Way of an Investigator. The following will provide a brief overview of the life and work of Forbes and Cannon. It will then discuss the way that Forbes used literature to express his views about the changing role of communications technology in the military, and his evolving view of the nervous system itself as a kind of information-processing device. It will go on to discuss the way that Cannon used literature to articulate the horrors he witnessed on the battlefield, as well as to contribute to the philosophy of science, and in particular, to the logic of scientific discovery. Finally, it will consider the historical and philosophical value of deeper investigation of the literary productions of scientists. © 2013 Elsevier B.V. All rights reserved.

  17. Expedition 8 Crew Interviews: Alexander Y. Kaleri - FE

    Science.gov (United States)

    2003-01-01

    Russian cosmonaut Alexander Y. Kaleri, Flight Engineer on Expedition 8 to the International Space Station (ISS), answers interview questions on this video, either himself or with the help of an interpreter. The questions cover: 1) The goal of the expedition; 2) The place in history of Mir; 3) The reaction to the loss of Columbia in Houston; 4) Why the rewards of spaceflight are worth the risks; 5) Why he decided to become a cosmonaut; 6) His memory of Yuri Gagarin's first flight; 7) What happens on a Soyuz capsule during launch and flight; 8) Are Soyuz maneuvers automatic or manual; 8) How the ISS science mission will be advanced during his stay; 9) The responsibilities of a Flight Engineer onboard the ISS; 10) Extravehicular activity (EVA) plans at that time; 11) The Shuttle Return to Flight and his preference for a Shuttle or Soyuz landing; 12) Why the last Soyuz landing was too rough; 13) The most valueable contribution of the ISS program.

  18. Spurensuche einer Rezeptionsgeschichte Alexander von Humboldt und Johann Gottfried Herder

    Directory of Open Access Journals (Sweden)

    Bernhard Hunger

    2009-05-01

    Full Text Available Article in German, Abstracts in English, German and Spanish.Alexander von Humboldt's work displays traces of Johann Gottfried Herder which are as multifaceted as the references to the latter are scarce. In light of this aspect, the present essay focuses on Humboldt's Physiognomy of Plants (1806, in which he explicitly mentions Herder for the first time in a publication. Two years later, the text is incorporated within Aspects of Nature (1808 ff.. In the third edition of Aspects (1849, Herder's name is curiously omitted. This omission is incomprehensible both in form and content. The historical context characterising the years between 1805 and 1808 suggests that Humboldt's references to Herder must have been made very deliberately. Humboldt's correspondence with the historian Johannes von M¸ller and other sources shows that Humboldt carefully studied Herder's writings. As the publisher of Herder's complete works, Johannes von M¸ller, who was Humboldtís friend and neighbour at the time, even considered Humboldt to be a direct descendant of the Herder school.

  19. Randomized controlled trial of the Alexander technique for idiopathic Parkinson's disease.

    Science.gov (United States)

    Stallibrass, C; Sissons, P; Chalmers, C

    2002-11-01

    To determine whether the Alexander Technique, alongside normal treatment, is of benefit to people disabled by idiopathic Parkinson's disease. A randomized controlled trial with three groups, one receiving lessons in the Alexander Technique, another receiving massage and one with no additional intervention. Measures were taken pre- and post-intervention, and at follow-up, six months later. The Polyclinic at the University of Westminster, Central London. Ninety-three people with clinically confirmed idiopathic Parkinson's disease. The Alexander Technique group received 24 lessons in the Alexander Technique and the massage group received 24 sessions of massage. The main outcome measures were the Self-assessment Parkinson's Disease Disability Scale (SPDDS) at best and at worst times of day. Secondary measures included the Beck Depression Inventory and an Attitudes to Self Scale. The Alexander Technique group improved compared with the no additional intervention group, pre-intervention to post-intervention, both on the SPDDS at best, p = 0.04 (confidence interval (CI) -6.4 to 0.0) and on the SPDDS at worst, p = 0.01 (CI -11.5 to -1.8). The comparative improvement was maintained at six-month follow-up: on the SPDDS at best, p = 0.04 (CI -7.7 to 0.0) and on the SPDDS at worst, p = 0.01 (CI -11.8 to -0.9). The Alexander Technique group was comparatively less depressed post-intervention, p = 0.03 (CI -3.8 to 0.0) on the Beck Depression Inventory, and at six-month follow-up had improved on the Attitudes to Self Scale, p = 0.04 (CI -13.9 to 0.0). There is evidence that lessons in the Alexander Technique are likely to lead to sustained benefit for people with Parkinson's disease.

  20. Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease.

    Science.gov (United States)

    Sosunov, Alexander A; Guilfoyle, Eileen; Wu, Xiaoping; McKhann, Guy M; Goldman, James E

    2013-04-24

    Alexander Disease (AxD) is a primary disorder of astrocytes, caused by heterozygous mutations in GFAP, which encodes the major astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP). Astrocytes in AxD display hypertrophy, massive increases in GFAP, and the accumulation of Rosenthal fibers, cytoplasmic protein inclusions containing GFAP, and small heat shock proteins. To study the effects of GFAP mutations on astrocyte morphology and physiology, we have examined hippocampal astrocytes in three mouse models of AxD, a transgenic line (GFAP(Tg)) in which the normal human GFAP is expressed in several copies, a knock-in line (Gfap(+/R236H)) in which one of the Gfap genes bears an R236H mutation, and a mouse derived from the mating of these two lines (GFAP(Tg); Gfap(+/R236H)). We report changes in astrocyte phenotype in all lines, with the most severe in the GFAP(Tg);Gfap(+/R236H), resulting in the conversion of protoplasmic astrocytes to cells that have lost their bushy-like morphology because of a reduction of distal fine processes, and become multinucleated and hypertrophic. Astrocytes activate the mTOR cascade, acquire CD44, and lose GLT-1. The altered astrocytes display a microheterogeneity in phenotypes, even neighboring cells. Astrocytes also show diminished glutamate transporter current, are significantly depolarized, and not coupled to adjacent astrocytes. Thus, the accumulation of GFAP in the AxD mouse astrocytes initiates a conversion of normal, protoplasmic astrocytes to astrocytes that display severely "reactive" characteristics, many of which may be detrimental to neighboring neurons and oligodendrocytes.

  1. Astrocyte pathology in Alexander disease causes a marked inflammatory environment.

    Science.gov (United States)

    Olabarria, Markel; Putilina, Maria; Riemer, Ellen C; Goldman, James E

    2015-10-01

    Astrocytes and microglia are commonly involved in a wide variety of CNS pathologies. However, they are typically involved in a secondary response in which many cell types are affected simultaneously and therefore it is difficult to know their contributions to the pathology. Here, we show that pathological astrocytes in a mouse model of Alexander disease (AxD; GFAP (Tg);Gfap (+/R236H)) cause a pronounced immune response. We have studied the inflammatory response in the hippocampus and spinal cord of these mice and have found marked microglial activation, which follows that of astrocytes in a spatial pathological progression, as shown by increased levels of Iba1 and microglial cell (Iba1+) density. RNA sequencing and subsequent gene ontology (GO) analysis revealed that a majority of the most upregulated genes in GFAP (Tg);Gfap (+/R236H) mice are directly associated with immune function and that cytokine and chemokine GO attributes represent nearly a third of the total immune attributes. Cytokine and chemokine analysis showed CXCL10 and CCL2 to be the most and earliest increased molecules, showing concentrations as high as EAE or stroke models. CXCL10 was localized exclusively to astrocytes while CCL2 was also present in microglia. Despite the high levels of CXCL10 and CCL2, T cell infiltration was mild and no B cells were found. Thus, mutations in GFAP are sufficient to trigger a profound inflammatory response. The cellular stress caused by the accumulation of GFAP likely leads to the production of inflammatory molecules and microglial activation. Examination of human AxD CNS tissues also revealed microglial activation and T cell infiltrates. Therefore, the inflammatory environment may play an important role in producing the neuronal dysfunction and seizures of AxD.

  2. Increased dynamic regulation of postural tone through Alexander Technique training.

    Science.gov (United States)

    Cacciatore, T W; Gurfinkel, V S; Horak, F B; Cordo, P J; Ames, K E

    2011-02-01

    Gurfinkel and colleagues (2006) recently found that healthy adults dynamically modulate postural muscle tone in the body axis during anti-gravity postural maintenance and that this modulation is inversely correlated with axial stiffness. Our objective in the present study was to investigate whether dynamic modulation of axial postural tone can change through training. We examined whether teachers of the Alexander Technique (AT), who undergo "long-term" (3-year) training, have greater modulation of axial postural tone than matched control subjects. In addition, we performed a longitudinal study on the effect of "short-term" (10-week) AT training on the axial postural tone of individuals with low back pain (LBP), since short term AT training has previously been shown to reduce LBP. Axial postural tone was quantified by measuring the resistance of the neck, trunk and hips to small (±10°), slow (1°/s) torsional rotation during stance. Modulation of tone was determined by the torsional resistance to rotation (peak-to-peak, phase-advance, and variability of torque) and axial muscle activity (EMG). Peak-to-peak torque was lower (∼50%), while phase-advance and cycle-to-cycle variability were enhanced for AT teachers compared to matched control subjects at all levels of the axis. In addition, LBP subjects decreased trunk and hip stiffness following short-term AT training compared to a control intervention. While changes in static levels of postural tone may have contributed to the reduced stiffness observed with the AT, our results suggest that dynamic modulation of postural tone can be enhanced through long-term training in the AT, which may constitute an important direction for therapeutic intervention. Copyright © 2010 Elsevier B.V. All rights reserved.

  3. The life and death of Alexander Bogdanov, physician.

    Science.gov (United States)

    Huestis, D W

    1996-08-01

    It was early in April in 1928 when the word went out in Moscow that Alexander Bogdanov had died. He was a controversial figure, an old Bolshevik who had left that party long before the 1917 revolution and never returned. All the same, he had had Lenin's respect as a scientist (as long as he stayed out of politics). More recently, he also had the support of the new party strong man, Stalin. Bogdanov opposed the growing despotism of the "dictatorship of the proletariat", under which slogan Communist autocracy was being developed. But he was respected as a tireless propagandist for the socialist cause, an enthusiastic teacher of the proletariat, and a writer of arcane science and philosophy. Bogdanov was held in such respect that Communist bigwigs spoke glowingly at the funeral, praising his intellect, courage, and dedication to science and humanity. They did not fail to point out that he had split with his one-time friend, Lenin, and had succumbed to ideological "errors". Indeed, he had powerful enemies in the early Soviet state. Bogdanov was a physician, economist, philosopher, natural scientist, writer of utopian science fiction, poet, teacher, politician (unsuccesful), lifelong revolutionary, forerunner of what we now call cybernetics and organizational science, and founder of the world's first institution devoted entirely to the field of blood transfusion. You could call him a Renaissance man. Although he clearly fitted the category of the late-nineteenth-century Russian intellectual revolutionary, Bogdanov differed from most of them in being no dilettante. More than just a theorist, he was an active scientist and physician. As a teacher, he firmly believed that education and indoctrination could alter people's ways of thinking and behaving, and that humanity could be perfected under socialism. Like many revolutionaries, Bogdanov tried to keep ahead of the Tsar's police by using a variety of pseudonyms, among them Riadavoy, Werner, Maximov, and Bogdanov. After

  4. Educating with the hands: working on the body/self in Alexander Technique.

    Science.gov (United States)

    Tarr, Jennifer

    2011-02-01

    Traditionally, forms of body work such as Alexander Technique have been excluded from mainstream biomedicine and healthcare, despite attempts by practitioners to have the work accepted within the medical community. Using data from a UK-based study of Alexander Technique which combined participant observation, interviews with 17 teachers and pupils, and analysis of historical texts, this article examines the relationship of the Alexander Technique to the field of healthcare, looking at its embodied practices, and contrasting these with the discourses in which it is framed. Applying Foucault's concept of 'techniques of the self', the article examines Alexander Technique's physical practices as a form of embodied knowledge, and goes on to look at its use of particular ideas about nature and evolution as guiding authorities, its emphasis on holism through its conception of the 'self', and how it has been positioned in relation to biomedical approaches. The article argues that while the embodied practice of Alexander Technique has much to offer to mainstream healthcare, the discourses and knowledge systems in which it is embedded make it unlikely to receive mainstream medical acceptance. © 2010 The Author. Sociology of Health & Illness © 2010 Foundation for the Sociology of Health & Illness/Blackwell Publishing Ltd.

  5. Obituary: Alexander (Andy) Franz Lubenow, 1956-2005

    Science.gov (United States)

    Buie, Marc William

    2006-12-01

    Alexander (Andy) Franz Lubenow, Program Coordinator at the Space Telescope Science Institute, was diagnosed with cancer of the gallbladder, pancreas, and liver in May 2005 and died on 29 September 2005. He was forty-nine. Andy was born to Bodo and Helen Lubenow in St. Paul, Minnesota on 4 January 1956. In 1964 at the age of eight, he moved with his family to Buenos Aires, Argentina, and attended the American Community School there until returning with his family in 1973 to St. Paul. Argentina had a big impact on Andy's future as an astronomer. He later recalled how he had observed and was puzzled by the "upside-down" appearance of the Moon in the southern hemisphere. In Argentina, he built his first telescope using a mirror he had ground himself. He never parted ways with that instrument. Andy did not follow a standard educational track. He spent two years at St. Olaf College in Northfield, Minnesota, before transferring to the University of Minnesota, where he earned his bachelor's degree and began work towards a master's degree in astrophysics. Later he transferred to the University of Illinois at Urbana-Champaign, where he remained until Dr. Peter Stockman hired him to work on the Hubble Space Telescope project. While in school, he worked as a teacher's assistant, taught night school, and gave demonstrations of stargazing. He was an excellent teacher and had a flair for writing. He later wrote articles for a sailing magazine and a pilot's magazine. Andy was a very practical, meticulous, and steady worker, attributes that he combined with an understated and dry sense of humor. He was always able to find a way through a problem, no matter how sticky. If a job required him to roll up his sleeves and get it done through hard work, he would persevere. Nevertheless, he was always on the lookout for an easier way. He had no patience for being forced to deal with stupid things for stupid reasons. At work at the Space Telescope Science Institute (STScI), Andy was

  6. Serial MRI changes in a patient with infantile Alexander disease and prolonged survival.

    Science.gov (United States)

    Shiihara, Takashi; Yoneda, Toru; Mizuta, Ikuko; Yoshida, Tomokatsu; Nakagawa, Masanori; Shimizu, Nobuzo

    2011-08-01

    Alexander disease is a major entity of leukodystrophy; magnetic resonance imaging (MRI) studies of the brain typically show extensive changes in the cerebral white matter with frontal predominance. Heterozygous missense mutations of GFAP are thought to be sufficient for the molecular diagnosis, which has widened the Alexander disease entity beyond the classical one. We report the patient, a 16-year-old Japanese boy, with infantile-onset Alexander disease, showing striking MRI findings; extreme white matter loss of cerebrum through cerebellum, severe atrophy of basal ganglia, cerebellum, brain stem, and cervical spinal cord. Molecular analysis showed a heterozygous mutation R239L (c.730G>T) in GFAP. A relative long disease course, over 15years, with the help of mechanical ventilation revealed the striking MRI progression. Copyright © 2010 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

  7. God-pleasing scientist – archpriest Alexander Gorsky (to the 140th anniversary of the repose

    Directory of Open Access Journals (Sweden)

    Melkov Andrey Sergeevich

    2015-10-01

    Full Text Available The article is devoted to the memory of archpriest Alexander Gorsky (1812–1875, Moscow Theological Academy’s rector, pastor of the Church, historian, specialist in archaeography, divine and pedagogue. The author analyzes father Alexander’s scientific-pedagogical and pastoral ministry through his God-pleasing and holy life, which can be cold sacramental saga. Archpriest Alexander was a highly moral person, and it was reflected on in his serving God, people and science. His course of life and scientific heritage are closely connected with interchurch, interstate and public relations in Russia of the 19th century. The author has come to the conclusion, that nowadays there are objective reasons for the starting archpriest Alexander Gorsky’s canonization process.

  8. Review: Alexander Thurston, Boko Haram: The History of an African Jihadist Movement, Princeton: Princeton University Press (2017)

    OpenAIRE

    Roman Loimeier

    2018-01-01

    Review of the monograph: Alexander Thurston, Boko Haram: The History of an African Jihadist Movement, Princeton: Princeton University Press, 2017, ISBN 9780691172248, 333 pp. Besprechung der Monographie: Alexander Thurston, Boko Haram: The History of an African Jihadist Movement, Princeton: Princeton University Press, 2017, ISBN 9780691172248, 333 Seiten

  9. Tartu ülikooli Vene ajaloo professor Alexander Brückner (1834-1896) / Tiit Rosenberg

    Index Scriptorium Estoniae

    Rosenberg, Tiit, 1946-

    2004-01-01

    Alexander Brückneri elust, vaadetest, loomingust ja perekonnast. Alexander Brücknerist kui Õpetatud Eesti Seltsi liikmest. Tartu Ülikooli vene ajaloo õppejõududest. Lühidalt Tartust pärit vene ajaloo uurijast Ernst Adolf Herrmannist

  10. IN MEMORIAM: In Memoriam: Alexander A Golovin and Alexei M Oparin In Memoriam: Alexander A Golovin and Alexei M Oparin

    Science.gov (United States)

    2008-10-01

    In Memoriam of Alexander A Golovin (1962-2008) Alexander (Sasha) Golovin passed away on 10 September 2008. Sasha's scientific heritage includes seminal works in different fields of physics, from Marangoni convection to self-assembly of quantum dots, and from combustion fronts to anomalous diffusion in flows and on a crystal surface. A graduate of the Moscow Institute for Physics and Technology, he had very broad scientific interests and a unique ability to identify and solve new, intellectually challenging and technologically important problems. One of the basic fields of Sasha's research was the fluid dynamics in systems with interfaces. His favorite subject was the motion of droplets, bubbles and particles in the presence of heat and mass transfer. Sasha's early works contained the discovery of the spontaneous motion of droplets due to the Marangoni effect and the investigation of the interaction between solid particles, bubbles and droplets caused by the Marangoni effect, which is a crucial factor that determines the effect of heat/mass transfer on the rate of coalescence. In both cases, Sasha's work was the first in a long sequence of papers written by different authors. Later, Sasha returned to that field when studying such fascinating subjects as levitation of droplets above the surface of an evaporating liquid and encapsulation of particles and bubbles by an advancing solidification front. The subject of interfacial hydrodynamics overlaps with another basic field of Sasha's research, the theory of pattern formation. The contribution of Sasha's work to the modern understanding of the variety of pattern formation phenomena is significant. It includes the analysis of the interaction between long-wave and short-wave instability modes in Marangoni convection, investigation of the large-scale Marangoni convection that led to the prediction of different patterns including quasipatterns, and the description of various non-potential effects in Marangoni convection

  11. Infantile-Onset Alexander Disease: A Genetically Proven Case With Mild Clinical Course in a 6-Year-Old Indian Boy

    NARCIS (Netherlands)

    Ramesh, K.; Sharma, S.; Kumar, A.; Salomons, G.S.; van der Knaap, M.S.; Gulati, S.

    2013-01-01

    Alexander disease is an autosomal dominant leukoencephalopathy characterized by developmental delay, macrocephaly, and characteristic neuroimaging abnormalities predominantly involving frontal lobes. We report a 6-year-old Indian boy with infantile-onset Alexander disease, who has an unusually mild

  12. Infantile-onset Alexander disease: a genetically proven case with mild clinical course in a 6-year-old Indian boy

    NARCIS (Netherlands)

    Ramesh, Konanki; Sharma, Suvasini; Kumar, Atin; Salomons, Gajja S.; van der Knaap, Marjo S.; Gulati, Sheffali

    2013-01-01

    Alexander disease is an autosomal dominant leukoencephalopathy characterized by developmental delay, macrocephaly, and characteristic neuroimaging abnormalities predominantly involving frontal lobes. We report a 6-year-old Indian boy with infantile-onset Alexander disease, who has an unusually mild

  13. German-Iowan Strategies in Celebrating the Centennial of Alexander von Humboldt’s Birth

    Directory of Open Access Journals (Sweden)

    Bill Roba

    2014-12-01

    Full Text Available The two largest cities of Eastern Iowa on the shore of the Mississippi River are Dubuque and Davenport. In each city, an elite group of German-Iowan leaders emerged by the late 1850s. Bill Roba describes and examines their strategies in celebrating the Centennial of Alexander von Humboldt’s Birth.

  14. MRI diagnosis of infantile Alexander disease in a 14 month old African boy.

    Science.gov (United States)

    Dlamini, Nondumiso; du Plessis, Vicci

    2016-10-01

    Alexander disease, also known as fibrinoid leukodystrophy, is a rare leukoencephalopathy which occurs due to a mutation in the glial fibrillary acid protein (GFAP) gene. Magnetic resonance imaging (MRI) has proven to be highly sensitive in making the diagnosis. Typical MRI findings, in combination with positive genetic blood analysis, confirm the diagnosis.

  15. Archetypal and new families with Alexander disease and novel mutations in GFAP

    NARCIS (Netherlands)

    Messing, Albee; Li, Rong; Naidu, Sakkubai; Taylor, J. Paul; Silverman, Lital; Flint, Daniel; van der Knaap, Marjo S.; Brenner, Michael

    2012-01-01

    To describe genetic analyses of the 2 most thoroughly studied, historically seminal multigenerational families with Alexander disease described prior to the identification of GFAP as the related gene, as well as 1 newly discovered family. Clinical histories were obtained and DNA was analyzed from

  16. Alexander Disease: A Novel Mutation in GFAP Leading to Epilepsia Partialis Continua.

    Science.gov (United States)

    Bonthius, Daniel J; Karacay, Bahri

    2016-06-01

    Alexander disease is a genetically induced leukodystrophy, due to dominant mutations in the glial fibrillary acidic protein (GFAP ) gene, causing dysfunction of astrocytes. We have identified a novel GFAP mutation, associated with a novel phenotype for Alexander disease. A boy with global developmental delay and hypertonia was found to have a leukodystrophy. Genetic analysis revealed a heterozygous point mutation in exon 6 of the GFAP gene. The guanine-to-adenine change causes substitution of the normal glutamic acid codon (GAG) with a mutant lysine codon (AAG) at position 312 (E312 K mutation). At the age of 4 years, the child developed epilepsia partialis continua, consisting of unabating motor seizures involving the unilateral perioral muscles. Epilepsia partialis continua has not previously been reported in association with Alexander disease. Whether and how the E312 K mutation produces pathologic changes and clinical signs that are unique from other Alexander disease-inducing mutations in GFAP remain to be determined. © The Author(s) 2015.

  17. Unraveling pathology in juvenile Alexander disease: serial quantitative MR imaging and spectroscopy of white matter.

    Science.gov (United States)

    van der Voorn, J Patrick; Pouwels, Petra J W; Salomons, Gajja S; Barkhof, Frederik; van der Knaap, Marjo S

    2009-10-01

    Alexander disease is a rare disorder of the central nervous system with characteristic symmetric white matter abnormalities with frontal predominance on magnetic resonance (MR) images. Histopathology shows a lack of myelin in the affected white matter, variably interpreted as hypomyelination or demyelination. To increase our insight into the nature of the pathology leading to the MR imaging findings in Alexander disease, we applied serial MR imaging, spectroscopy, magnetization transfer (MT) imaging (MTI), and diffusion tensor imaging (DTI) in six patients with juvenile Alexander disease. The MR imaging protocol comprised T1- and T2-weighted spin echo images and fluid-attenuated inversion recovery images. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), and MT ratio (MTR) maps were generated, and MR spectroscopy concentrations were quantified for several metabolites. MR imaging showed similar cerebral white matter abnormalities in all patients, with only minor increase on prolonged follow-up, despite sometimes serious clinical progression. MR spectroscopy showed highly elevated levels of myo-inositol, lactate, and choline-containing compounds and decreased total N-acetyl-aspartate and N-acetyl-aspartyl-glutamate levels in the abnormal white matter. High values of ADC were observed, and both FA and MTR were attenuated. The sequential MR imaging findings in Alexander disease provide strong evidence against active demyelination as sole explanation for the underlying pathology. An alternative explanation for our spectroscopic, DTI, and MTI findings-which would suggest demyelination-could be hyperplasia and hypertrophy of astrocytes, as seen in low grade gliomas.

  18. Diagnosis by whole exome sequencing of atypical infantile onset Alexander disease masquerading as a mitochondrial disorder.

    Science.gov (United States)

    Nishri, Daniella; Edvardson, Simon; Lev, Dorit; Leshinsky-Silver, Esther; Ben-Sira, Liat; Henneke, Marco; Lerman-Sagie, Tally; Blumkin, Lubov

    2014-07-01

    There are many similarities, both clinical and radiological, between mitochondrial leukoencephalopathies and Alexander disease, an astrogliopathy. Clinically, both can manifest with a myriad of symptoms and signs, arising from the neonatal period to adulthood. Radiologically, both can demonstrate white matter changes, signal abnormalities of basal ganglia or thalami, brainstem abnormalities and contrast enhancement of white matter structures. Magnetic resonance spectroscopy may reveal elevation of lactate in the abnormal white matter in Alexander disease making the distinction even more challenging. We present a child who was considered to have an infantile onset mitochondrial disorder due to a combination of neurological symptoms and signs (developmental regression, failure to thrive, episodic deterioration, abnormal eye movements, pyramidal and cerebellar signs), urinary excretion of 3-methyl-glutaconic acid and imaging findings (extensive white matter changes and cerebellar atrophy) with a normal head circumference. Whole exome sequence analysis was performed. The child was found to harbor the R416W mutation, one of the most prevalent mutations in the glial fibrillary acidic protein (GFAP) gene that causes Alexander disease. Alexander disease should be considered in the differential diagnosis of infantile leukoencephalopathy, even when no macrocephaly is present. Next generation sequencing is a useful aid in unraveling the molecular etiology of leukoencephalopathies. Copyright © 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

  19. Russia's Literary Genius Alexander Pushkin: The Great-Grandson of an African Slave.

    Science.gov (United States)

    Lounsbery, Anne

    2000-01-01

    Alexander Pushkin, Russia's most celebrated literary figure, descended from an African slave. On both parents' sides, he was related to Avram Petrovich Gannibal, who was born to an African prince and abducted to become a slave to a Russian diplomat. Pushkin chose to pride himself on both his aristocratic life and his African ancestry. (SM)

  20. Not a rainbow but a river prospects for a nonracial future | Alexander ...

    African Journals Online (AJOL)

    At the time of writing in 2001, the late South African educator Neville Alexander was directing the Project for the Study of Alternative Education in South Africa at the University of Cape Town. Mahmood Mamdani was (and is) the Herbert Lehman Professor of Government at the School of International and Public Affairs and ...

  1. THE 19th CENTURY EDITIONS OF THE LIFE OF ALEXANDER OSHEVENSKY

    Directory of Open Access Journals (Sweden)

    Alexander Valerievich Pigin

    2013-11-01

    Full Text Available This article is devoted to a classic of the 16th-century north Russian hagiography — The Life of Alexander Oshevensky, which is preserved as a large number of various copies and editions. The 19th-century materials recently found in the Russian archives enabled researchers to raise a question of the late period in the literary history of this Life. Three editions of this piece of writing created in the 1820’s and 1830’s by Tikhvin Monastery’s Archimandrite Hilarion (Kirillov, Alexander Svirsky Monastery’s Archimandrite Barsanuphius (Morev and Archbishop of Olonets Ignatius (Semyonov are in the focus of this paper. The new editions were written with the intention to be published to glorify St. Alexander across Russia, though respective petitions to the Most Holy Synod were not approved. This article detects sources of these editions and shows the pattern of processing of the initial texts. As the text analysis has shown, the 19th-century editions primarily developed the topoi of book learning and relationships between St. Alexander and his family. The Life used to be revised stylistically and compositionally, as well as supplemented with historical information. The published material is of interest for the research in poetics and topics of the Liеves of the Saints and their perception by the church writers of the 19th century.

  2. How Alexander von Humboldt's life story can inspire innovative soil research in developing countries

    Directory of Open Access Journals (Sweden)

    J. Bouma

    2017-09-01

    Full Text Available The pioneering vision of Alexander von Humboldt of science and society of the early 1800s is still highly relevant today. His open mind and urge to make many measurements characterizing the interconnected web of life are crucial ingredients as we now face the worldwide challenge of the UN Sustainable Development Goals. Case studies in the Philippines, Vietnam, Kenya, Niger, and Costa Rica demonstrate, in Alexander's spirit, interaction with stakeholders and attention to unique local conditions, applying modern measurement and modeling methods and allowing inter- and transdisciplinary research approaches. But relations between science and society are increasingly problematic, partly as a result of the information revolution and post-truth, fact-free thinking. Overly regulated and financially restricted scientific communities in so-called developed countries may stifle intellectual creativity. Researchers in developing countries are urged to leapfrog these problems in the spirit of Alexander von Humboldt as they further develop their scientific communities. Six suggestions to the science community are made with particular attention to soil science. (The Humboldt lecture, presented by the 2017 recipient of the Alexander von Humboldt lecture, Johan Bouma, can be accessed at http://client.cntv.at/egu2017/ml1.

  3. Identification of metapopulation dynamics among Northern Goshawks of the Alexander Archipelago, Alaska, and Coastal British Columbia

    Science.gov (United States)

    Sonsthagen, Sarah A.; McClaren, Erica L.; Doyle, Frank I.; Titus, K.; Sage, George K.; Wilson, Robert E.; Gust, Judy R.; Talbot, Sandra L.

    2012-01-01

    Northern Goshawks occupying the Alexander Archipelago, Alaska, and coastal British Columbia nest primarily in old-growth and mature forest, which results in spatial heterogeneity in the distribution of individuals across the landscape. We used microsatellite and mitochondrial data to infer genetic structure, gene flow, and fluctuations in population demography through evolutionary time. Patterns in the genetic signatures were used to assess predictions associated with the three population models: panmixia, metapopulation, and isolated populations. Population genetic structure was observed along with asymmetry in gene flow estimates that changed directionality at different temporal scales, consistent with metapopulation model predictions. Therefore, Northern Goshawk assemblages located in the Alexander Archipelago and coastal British Columbia interact through a metapopulation framework, though they may not fit the classic model of a metapopulation. Long-term population sources (coastal mainland British Columbia) and sinks (Revillagigedo and Vancouver islands) were identified. However, there was no trend through evolutionary time in the directionality of dispersal among the remaining assemblages, suggestive of a rescue-effect dynamic. Admiralty, Douglas, and Chichagof island complex appears to be an evolutionarily recent source population in the Alexander Archipelago. In addition, Kupreanof island complex and Kispiox Forest District populations have high dispersal rates to populations in close geographic proximity and potentially serve as local source populations. Metapopulation dynamics occurring in the Alexander Archipelago and coastal British Columbia by Northern Goshawks highlight the importance of both occupied and unoccupied habitats to long-term population persistence of goshawks in this region.

  4. Alexander Pechersky Testifies: an Open Page of Sobibor Death Camp History

    OpenAIRE

    Lev S. Simkin

    2013-01-01

    Here, the author introduces the interrogation of the witness Alexander Aronovich Pechersky, the leader of the German death camp Sobibor Revolt during the World War II. Special attention is attached to the daily life of the death camp. The picture of revolt preparation was completed

  5. Alexander Pechersky Testifies: an Open Page of Sobibor Death Camp History

    Directory of Open Access Journals (Sweden)

    Lev S. Simkin

    2013-01-01

    Full Text Available Here, the author introduces the interrogation of the witness Alexander Aronovich Pechersky, the leader of the German death camp Sobibor Revolt during the World War II. Special attention is attached to the daily life of the death camp. The picture of revolt preparation was completed

  6. Synoptisches Erzählen - Darstellungen des Bombenkriegs bei Gert Ledig, Alexander Kluge und Dieter Forte

    DEFF Research Database (Denmark)

    Hoffmann, Birthe

    2009-01-01

    Artiklen foretager en sammenlignende analyse af Gert Ledigs roman "Vergeltung" (1956), Alexander Kluges hybride tekst "Der Luftangriff auf Halberstadt am 8. April 1945" (1976) og Dieter Fortes roman "Der Junge mit den Blutigen Schuhen" (1995) med henblik på en diskussion af fortællemæssige strate...... strategier overfor bombardementerne af den tyske civilbefolkning under 2. Verdenskrig....

  7. 78 FR 53630 - Airworthiness Directives; Alexander Schleicher GmbH & Co. Segelflugzeugbau Sailplanes

    Science.gov (United States)

    2013-08-30

    ... Alexander Schleicher Technische Mitteilung (English translation: Technical Note) TM-Nr. 13 for Ka 2 and Ka... Schleicher Technische Mitteilung (English translation: Technical Note) TM-Nr. 13 for Ka 2 and Ka 2b, TM-Nr... Technische Mitteilung (English translation: Technical Note) TM-Nr. 13 for Ka 2 and Ka 2b, TM-Nr. 26 for Ka 6...

  8. Close to the Clothes : Materiality and Sophisticated Archaism in Alexander van Slobbe’s Design Practices

    NARCIS (Netherlands)

    Baronian, M.-A.

    2017-01-01

    This article looks at the work of contemporary Dutch fashion designer Alexander van Slobbe (1959) and examines how, since the 1990s, his fashion practices have consistently and consciously put forward a unique reflection on questions related to materiality, sophisticated archaism, luxury,

  9. Connect the Book. Always Inventing: A Photobiography of Alexander Graham Bell

    Science.gov (United States)

    Brodie, Carolyn S.

    2004-01-01

    Cell phones, video phones, voice messaging?one wonders what Alexander Graham Bell would have thought about the many venues today for electronic communication with one another. Bell's March 10, 1876 invention is now 128 years old, but there is no doubt that Bell's "talking machine" changed the world. This article presents a brief review of the…

  10. The Language of Teaching Coordination: Suzuki Training Meets the Alexander Technique.

    Science.gov (United States)

    Madden, Catherine

    2002-01-01

    Details an investigation of the language of Suzuki instruction and the students' interpretation of that language. Describes the Alexander Technique and Suzuki training and provides specific examples illustrating the interaction of language and coordination in this context. Proposes that teachers of movement, voice and acting can benefit from these…

  11. [Posttreatment stability of four first bicuspid extraction cases treated with the Alexander technique--model analysis].

    Science.gov (United States)

    Wei, Song; Fu, Min-kui

    2005-07-01

    To evaluate the posttreatment stability of four first bicuspid extraction cases with the Alexander technique. Fifteen patients, 8 males and 7 females in the permanent dentition were selected. The age range of the patients was 10.3 to 16.2 years old. Four first bicuspids of every patient were extracted and all patients were treated with the Alexander technique. The study casts were taken before (T(1)), after treatment (T(2)) and 27.8 months averagely follow-up (T(3)). Data were correlated by means of paired t tests. Although maxillary and mandibular intercanine widths were increased by 0.98 mm and 0.87 mm, respectively, during treatment, they were decreased by 0.37 mm and 0.72 mm, respectively, during follow-up period. Maxillary and mandibular crowding were increased by 0.53 mm and 0.98 mm, respectively, during follow-up period. No statistical significance were found. Upper and lower arch depth were decreased significantly due to retraction of anterior teeth and remained stable during follow-up period. According to this study, the design of the Alexander appliance and the Alexander technique are helpful for stability of extraction therapy. Follow-up is still necessary to evaluate the long-term stability.

  12. How Alexander von Humboldt's life story can inspire innovative soil research in developing countries

    Science.gov (United States)

    Bouma, Johan

    2017-09-01

    The pioneering vision of Alexander von Humboldt of science and society of the early 1800s is still highly relevant today. His open mind and urge to make many measurements characterizing the interconnected web of life are crucial ingredients as we now face the worldwide challenge of the UN Sustainable Development Goals. Case studies in the Philippines, Vietnam, Kenya, Niger, and Costa Rica demonstrate, in Alexander's spirit, interaction with stakeholders and attention to unique local conditions, applying modern measurement and modeling methods and allowing inter- and transdisciplinary research approaches. But relations between science and society are increasingly problematic, partly as a result of the information revolution and post-truth, fact-free thinking. Overly regulated and financially restricted scientific communities in so-called developed countries may stifle intellectual creativity. Researchers in developing countries are urged to leapfrog these problems in the spirit of Alexander von Humboldt as they further develop their scientific communities. Six suggestions to the science community are made with particular attention to soil science. (The Humboldt lecture, presented by the 2017 recipient of the Alexander von Humboldt lecture, Johan Bouma, can be accessed at http://client.cntv.at/egu2017/ml1.)

  13. Stubb : EL saavutas Gruusia kriisi ajal palju / Alexander Stubb ; interv. Liisi Poll

    Index Scriptorium Estoniae

    Stubb, Alexander, 1968-

    2008-01-01

    Intervjuu Soome välisministri Alexander Stubbiga, kes vastab küsimustele, mis puudutavad Euroopa Liidu positsiooni seoses Venemaa agressiooniga Gruusias ja Soome seisukohti seoses NATOga. Euroliidu reaktsioon Venemaa agressioonile Gruusias oli poliitiliselt tugev ja majanduslikult nõrk, arvab ta

  14. Alexander Technique Lessons or Acupuncture Sessions for Persons With Chronic Neck Pain: A Randomized Trial.

    Science.gov (United States)

    MacPherson, Hugh; Tilbrook, Helen; Richmond, Stewart; Woodman, Julia; Ballard, Kathleen; Atkin, Karl; Bland, Martin; Eldred, Janet; Essex, Holly; Hewitt, Catherine; Hopton, Ann; Keding, Ada; Lansdown, Harriet; Parrott, Steve; Torgerson, David; Wenham, Aniela; Watt, Ian

    2015-11-03

    Management of chronic neck pain may benefit from additional active self-care-oriented approaches. To evaluate clinical effectiveness of Alexander Technique lessons or acupuncture versus usual care for persons with chronic, nonspecific neck pain. Three-group randomized, controlled trial. (Current Controlled Trials: ISRCTN15186354). U.K. primary care. Persons with neck pain lasting at least 3 months, a score of at least 28% on the Northwick Park Questionnaire (NPQ) for neck pain and associated disability, and no serious underlying pathology. 12 acupuncture sessions or 20 one-to-one Alexander lessons (both 600 minutes total) plus usual care versus usual care alone. NPQ score (primary outcome) at 0, 3, 6, and 12 months (primary end point) and Chronic Pain Self-Efficacy Scale score, quality of life, and adverse events (secondary outcomes). 517 patients were recruited, and the median duration of neck pain was 6 years. Mean attendance was 10 acupuncture sessions and 14 Alexander lessons. Between-group reductions in NPQ score at 12 months versus usual care were 3.92 percentage points for acupuncture (95% CI, 0.97 to 6.87 percentage points) (P = 0.009) and 3.79 percentage points for Alexander lessons (CI, 0.91 to 6.66 percentage points) (P = 0.010). The 12-month reductions in NPQ score from baseline were 32% for acupuncture and 31% for Alexander lessons. Participant self-efficacy improved for both interventions versus usual care at 6 months (P Alexander lessons, 3.33 percentage points [CI, 2.22 to 4.44 percentage points]). No reported serious adverse events were considered probably or definitely related to either intervention. Practitioners belonged to the 2 main U.K.-based professional associations, which may limit generalizability of the findings. Acupuncture sessions and Alexander Technique lessons both led to significant reductions in neck pain and associated disability compared with usual care at 12 months. Enhanced self-efficacy may partially explain why longer

  15. Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease model.

    Science.gov (United States)

    Wang, Liqun; Colodner, Kenneth J; Feany, Mel B

    2011-02-23

    Although alterations in glial structure and function commonly accompany death of neurons in neurodegenerative diseases, the role glia play in modulating neuronal loss is poorly understood. We have created a model of Alexander disease in Drosophila by expressing disease-linked mutant versions of glial fibrillary acidic protein (GFAP) in fly glia. We find aggregation of mutant human GFAP into inclusions bearing the hallmarks of authentic Rosenthal fibers. We also observe significant toxicity of mutant human GFAP to glia, which is mediated by protein aggregation and oxidative stress. Both protein aggregation and oxidative stress contribute to activation of a robust autophagic response in glia. Toxicity of mutant GFAP to glial cells induces a non-cell-autonomous stress response and subsequent apoptosis in neurons, which is dependent on glial glutamate transport. Our findings thus establish a simple genetic model of Alexander disease and further identify cellular pathways critical for glial-induced neurodegeneration.

  16. Novel GFAP Variant in Adult-onset Alexander Disease With Progressive Ataxia and Palatal Tremor.

    Science.gov (United States)

    Gass, Jennifer M; Cheema, Anvir; Jackson, Jessica; Blackburn, Patrick R; Van Gerpen, Jay; Atwal, Paldeep S

    2017-11-01

    Alexander disease is a rare neurodegenerative disease caused by variants in the glial fibrillary acidic protein gene (GFAP). This disorder can develop as an infantile, juvenile or adult-onset form and is characterized by several clinical features, including macrocephaly, seizures, ataxia, and bulbar/pseudobulbar signs. While the majority of these patients have the more progressive infantile form which causes severe leukodystrophy and early death; the less common adult form is more variable (ie, onset age, symptoms), with bulbar dysfunction as the primary feature. In our investigation, we describe a patient with progressive neuromuscular issues including dyspnea, dysphagia, dysarthria and progressive ataxia with palatal tremor. Through genetic testing, we determined that our patient has a novel variant in GFAP typical of Alexander disease.

  17. [Physician of Obukhov school (90 years of the birth of Alexander Nikolayevich Senenko)].

    Science.gov (United States)

    Simonenko, V B

    2012-01-01

    At the beginning of December 2011 turns the 90th anniversary of a prominent national physician Alexander Nikolayevich Senenko. He was an educatee of the two academies--Military Medical Kirov (graduated with honors in March 1944) and the Naval Medical (VMMA), where he studied at post-graduate at the Department of Faculty Therapy (1950-1953). The results of the scientific work of the department summarized in the monograph of Gogin E.E., Senenko A.N., Tyurin E.I., "Arterial Hypertension" (1978, 1983). Monograph of Senenko A.N. "Heart and focal infection" (1973) has not lost its scientific and practical importance to this day. Shortly before the death (June 1, 1991), Alexander Nikolaevich completed the major work on the role of focal infection in the pathology of internal organs. In all he published over 250 scientific papers, including one textbook, four monographs and several major textbooks.

  18. Unusual diagnosis in a child suffering from juvenile Alexander disease: clinical and imaging report.

    Science.gov (United States)

    Franzoni, Emilio; Van der Knaap, Marjo S; Errani, Alessandra; Colonnelli, Maria Chiara; Bracceschi, Roberta; Malaspina, Elisabetta; Moscano, Filomena Caterina; Garone, Caterina; Sarajlija, Jasenka; Zimmerman, Robert A; Salomons, Gajja S; Bernardi, Bruno

    2006-12-01

    Alexander disease is a rare, sporadic leukoencephalopathy characterized by white-matter abnormalities with frontal predominance and, as a rule, clinically associated with megalencephaly, seizures, spasticity, and psychomotor deterioration. We describe a boy who was diagnosed as affected by anorexia nervosa because of his refusal to eat, progressive weight loss, and psychologic disturbances. The observation of a hyperintense lesion on T(2)-weighed magnetic resonance images (MRIs) was initially explained as a pontine and extrapontine myelinolysis related to malnutrition. Following MRI and DNA analysis, we diagnosed a juvenile type of Alexander disease. Therefore, we can affirm the importance of the history and clinical examination to look for brainstem dysfunction in patients presenting with atypical anorexia nervosa.

  19. [Urology and National Socialism: the fate of Alexander von Lichtenberg 1880-1949].

    Science.gov (United States)

    Moll, F H; Krischel, M; Rathert, P; Fangerau, H

    2010-09-01

    Alexander von Lichtenberg (1880-1949) was one of the famous members of the German Urological Society (DGU) in pre-war Germany. He introduced excretion urography and a special TURP Instrument. In 1928 he was president of the 8th meeting held in the German capital Berlin. His Handbook of Urology, released by Ferdinand Springer publishing house, was a trendsetter in establishing urology as a specialty in Germany and bringing together the whole wisdom of all aspects of urology. He was the founder of the famous Maximilian Nitze Award of the DGU. As a Jew he-like many others-was forced to leave Nazi Germany after 1933. Even in Hungary, his native country, he again had to resist anti-Semitic hostility. Later on he lived in Mexico. Alexander von Lichtenberg has to be remembered with special focus on the exodus of German Jewish scientists during the Nazi time.

  20. Der Briefwechsel zwischen Alexander von Humboldt und Karl Ernst von Baer

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    Thomas Schmuck

    2012-10-01

    Full Text Available Zusammenfassung Der kurze, nicht vollständig erhaltene Briefwechsel zwischen Alexander von Humboldt und Karl Ernst von Baer behandelt sehr verschiedene Themen: Politik, Kriegsgefahr, den Wissenschaftsbetrieb, Auszeichnungen und Tagungen, Embryologie und Cholera. Gemeinsam mit Briefen und Reden ergibt sich dabei ein differenziertes Bild der Beurteilung der beiden Wissenschaftler durch den jeweils anderen. Während Baer sich als Bewunderer Humboldts erweist, erscheint umgekehrt Humboldts Einschätzung Baers als ambivalent. Abstract The short, not completely preserved correspondence between Alexander von Humboldt and Karl Ernst von Baer deals with a wide range of subjects: politics and the danger of war, academic activities, scientific awards and conferences, aspects of embryology and the cholera. Letters to third persons and speeches, together with the correspondence between Humboldt and Baer show a differentiated pattern of mutual appraisal: While Baer always remained an admirer of the elder naturalist, Humboldt’s estimation was characterized by ambivalence.

  1. Unterwegs zu einer Weltwissenschaft? Alexander von Humboldts Weltbegriffe und die transarealen Studien

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    Ottmar Ette

    2006-10-01

    Full Text Available Article in German, Abstracts in English, German and Spanish.Alexander von Humboldt's world concepts inscribe themselves in the tradition of a reflexion on the second period of accerelated globalization during the second half of the 18th century. The polysemic structure of concepts like world consciousness (Weltbewusstsein is embetted in a vision, understanding and practice of science that can be described as transdisciplinary, intercultural, democraticaly popularizing, cosmopolitan, fractal and transregional. Alexander von Humboldt's new discourse on the Americas can be best understood as a fine example for TransArea Studies highlighting an area's characteristics by developing its relationships and dynamics within a worldwide network of informations, dependencies, exchanges and correspondances.

  2. Randomised controlled trial of Alexander technique lessons, exercise, and massage (ATEAM) for chronic and recurrent back pain: economic evaluation.

    Science.gov (United States)

    Hollinghurst, Sandra; Sharp, Debbie; Ballard, Kathleen; Barnett, Jane; Beattie, Angela; Evans, Maggie; Lewith, George; Middleton, Karen; Oxford, Frances; Webley, Fran; Little, Paul

    2008-12-11

    An economic evaluation of therapeutic massage, exercise, and lessons in the Alexander technique for treating persistent back pain. Cost consequences study and cost effectiveness analysis at 12 month follow-up of a factorial randomised controlled trial. 579 patients with chronic or recurrent low back pain recruited from primary care. Normal care (control), massage, and six or 24 lessons in the Alexander technique. Half of each group were randomised to a prescription for exercise from a doctor plus behavioural counselling from a nurse. Costs to the NHS and to participants. Comparison of costs with Roland-Morris disability score (number of activities impaired by pain), days in pain, and quality adjusted life years (QALYs). Comparison of NHS costs with QALY gain, using incremental cost effectiveness ratios and cost effectiveness acceptability curves. Intervention costs ranged from pound30 for exercise prescription to pound596 for 24 lessons in Alexander technique plus exercise. Cost of health services ranged from pound50 for 24 lessons in Alexander technique to pound124 for exercise. Incremental cost effectiveness analysis of single therapies showed that exercise offered best value ( pound61 per point on disability score, pound9 per additional pain-free day, pound2847 per QALY gain). For two-stage therapy, six lessons in Alexander technique combined with exercise was the best value (additional pound64 per point on disability score, pound43 per additional pain-free day, pound5332 per QALY gain). An exercise prescription and six lessons in Alexander technique alone were both more than 85% likely to be cost effective at values above pound20 000 per QALY, but the Alexander technique performed better than exercise on the full range of outcomes. A combination of six lessons in Alexander technique lessons followed by exercise was the most effective and cost effective option.

  3. The birth of Russian intelligentsia from the spirit of the enlightenment: Alexander Radishchev

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    Subotić Milan

    2009-01-01

    Full Text Available This text is the second part of a study about Alexander Radishchev, one of the leading representatives of Enlightenment in Russia's XVIII Century. Starting with explanation of the 'enlightened absolutism' of Catherine the Great, the author analyses the political and social ideas presented in Radishchev's book Journey from St. Petersburg to Moscow. Considering Radishchev as a 'father of Russian intelligentsia', the author stress that Radishchev's social criticism anticipated the later phenomenon of 'dissidence'.

  4. Review: Alexander Bogner, Beate Littig & Wolfgang Menz (Hrsg.) (2002). Das Experteninterview. Theorie, Methode, Anwendung

    OpenAIRE

    Bührmann, Andrea D.

    2004-01-01

    Die Herausgeber des Sammel­bandes Experteninterview, Alexander BOG­NER, Beate LITTIG und Wolfgang MENZ, zielen auf eine kritische Reflexion der methodologischen Grundlagen, der konkreten Erhebungsmethoden so­wie der praktischen Anwendungsfelder des Exper­tInneninterviews. Gemäß dieser komplexen Ziel­setzung ist der Sammelband dreigeteilt: In einem ersten Teil werden theoretische Konzepte dis­kutiert, im zweiten Teil geht es um Techniken und Interaktionsstrategien und schließlich werden im dri...

  5. Antisense suppression of glial fibrillary acidic protein as a treatment for Alexander disease.

    Science.gov (United States)

    Hagemann, Tracy L; Powers, Berit; Mazur, Curt; Kim, Aneeza; Wheeler, Steven; Hung, Gene; Swayze, Eric; Messing, Albee

    2017-12-11

    Alexander disease is a fatal leukodystrophy caused by autosomal dominant gain-of-function mutations in the gene for glial fibrillary acidic protein (GFAP), an intermediate filament protein primarily expressed in astrocytes of the central nervous system. A key feature of pathogenesis is overexpression and accumulation of GFAP, with formation of characteristic cytoplasmic aggregates known as Rosenthal fibers. Here we investigate whether suppressing GFAP with antisense oligonucleotides could provide a therapeutic strategy for treating Alexander disease. In this study, we use GFAP mutant mouse models of Alexander disease to test the efficacy of antisense suppression and evaluate the effects on molecular and cellular phenotypes and non-cell-autonomous toxicity. Antisense oligonucleotides were designed to target the murine Gfap transcript, and screened using primary mouse cortical cultures. Lead oligonucleotides were then tested for their ability to reduce GFAP transcripts and protein, first in wild-type mice with normal levels of GFAP, and then in adult mutant mice with established pathology and elevated levels of GFAP. Nearly complete and long-lasting elimination of GFAP occurred in brain and spinal cord following single bolus intracerebroventricular injections, with a striking reversal of Rosenthal fibers and downstream markers of microglial and other stress-related responses. GFAP protein was also cleared from cerebrospinal fluid, demonstrating its potential utility as a biomarker in future clinical applications. Finally, treatment led to improved body condition and rescue of hippocampal neurogenesis. These results demonstrate the efficacy of antisense suppression for an astrocyte target, and provide a compelling therapeutic approach for Alexander disease. Ann Neurol 2017. © 2017 American Neurological Association.

  6. Infantile Onset Alexander Disease with Normal Head Circumference: A Genetically Proven Case Report

    OpenAIRE

    Goyal, Manisha; Mehndiratta, Sumit; Faruq, Mohammed; Dwivedi, Manish Kumar; Kapoor, Seema

    2014-01-01

    Alexander disease (AD) is an autosomal dominant leukodystrophy which predominantly affects infants and children. The infantile form comprises the most common form of AD. It presents before two years of age and characterized by macrocephaly, psychomotor regression, spasticity, pyramidal sign, ataxia and seizures. The diagnosis is based on magnetic resonance imaging (MRI) findings and confirmed by Glial fibrillary acidic protein (GFAP) gene molecular testing. We report an Indian case with norma...

  7. Infantile onset alexander disease with normal head circumference: a genetically proven case report.

    Science.gov (United States)

    Goyal, Manisha; Mehndiratta, Sumit; Faruq, Mohammed; Dwivedi, Manish Kumar; Kapoor, Seema

    2014-11-01

    Alexander disease (AD) is an autosomal dominant leukodystrophy which predominantly affects infants and children. The infantile form comprises the most common form of AD. It presents before two years of age and characterized by macrocephaly, psychomotor regression, spasticity, pyramidal sign, ataxia and seizures. The diagnosis is based on magnetic resonance imaging (MRI) findings and confirmed by Glial fibrillary acidic protein (GFAP) gene molecular testing. We report an Indian case with normal head circumference.

  8. Alexander von Humboldt y el relato de su viaje americano redactado en Filadelfia

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    Puig-Samper, Miguel Ángel

    2002-04-01

    Full Text Available This paper presents for the first time in Spanish language the autobiographical memoir that Alexander von Humboldt handed over to the American Philosophical Society in Philadelphia. This text was written in June 1804 during Alexander von Humboldt´s stay in the United States of America, when he was about to end his well-known American expedition. It constitutes the first —and until now the only— complete description of the expedition undertaken by the Prussian traveller. In order to present these series of autobiographical notes that Alexander von Humboldt wrote through his life, these memoirs will be mentioned briefly in the introduction of the paper in order to define the characteristics of the particular text introduced.

    En este artículo se da a conocer la memoria autobiográfica que Alexander von Humboldt entregó en la American Philosophical Society de Filadelfia, por primera vez en su traducción al español. Este texto fue redactado en junio de 1804 durante su estancia en los Estados Unidos, cuando estaba finalizando su famosa expedición americana y constituye la primera —y hasta ahora única— narración completa de esta expedición hecha por el viajero prusiano. Con objeto de encuadrar bien este texto en una serie de notas autobiográficas que escribió Humboldt a lo largo de su vida, en la introducción se mencionan brevemente estas memorias, para después definir las características del escrito presentado aquí.

  9. The Alexander Technique and musicians: a systematic review of controlled trials

    OpenAIRE

    Klein, Sabine; Bayard, Claudine; Wolf, Ursula

    2014-01-01

    BACKGROUND: Musculoskeletal disorders, stress and performance anxiety are common in musicians. Therefore, some use the Alexander Technique (AT), a psycho-physical method that helps to release unnecessary muscle tension and re-educates non-beneficial movement patterns through intentional inhibition of unwanted habitual behaviours. According to a recent review AT sessions may be effective for chronic back pain. This review aimed to evaluate the evidence for the effectiveness of AT sessions o...

  10. Reflection in Russian public opinion accession to the throne of Emperor Alexander II

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    Maxim N. Krot

    2016-03-01

    Full Text Available The article deals with the perception of Russian society coming to the throne of Emperor Alexander II in 1855. The author analyzes the internal and external situation in Russia in this period, identifying the most significant factors that influenced the public's attitude to the new monarch, and the expectations that were associated with his coming to power. The article draws parallels between the initial period of the reign of the two liberal Russian monarchs of the XIX century – Alexander I and Alexander II, most clearly expressed not so much in the circumstances of their accession, but in the public mood that prevailed in the country. It presents a broad picture of the "awakening" of public consciousness and activity after the stagnation and oppression of the preceding reign, which was reflected primarily in an effort to think freely and to discuss pressing issues facing the country, as well as contribute to the supreme power in the modernization of social and political relations, awareness where necessary, at this time it becomes clearly. The author identifies semantic levels of social consciousness of the period, indicating the particular circumstances that have shaped them. Much attention is paid to the influence of Russian society of the Crimean War, which in many ways was the starting point of social upheaval transformed in 1855 from a national-patriotic in the socio-political. The author points out that at this time has unique conditions for overcoming the contradictions between state and society and their successful cooperation in the reform of the country. This suggests a significant, perhaps - the crucial role of the public in the selection of the vector conversion of Russia, which has become a feature of the reign of Alexander II.

  11. Herbicide selectivity in the early development of Alexander palm and peach palm

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    Juliana Roberta Gobi Queiroz

    2016-10-01

    Full Text Available Herbicides are an efficient weed-control method, and herbicide selectivity with regard to palm species is an important subject of agricultural research. Owing to a lack of studies in the literature regarding the use of herbicides on palm trees, especially during the early stages of growth, the present study aimed to evaluate the selectivity of some herbicides during the early development of Alexander palm (Archontophoenix alexandrae and peach palm (Bactris gasipaes seedlings. The study was conducted in two seasons in a completely randomized design with eight treatments and four repetitions. The herbicide treatments and dosages (g i.a. ha-1, were as follows: fluazifop-p-butyl (93.8, sethoxydim (184.0, quizalofop-p-ethyl (75.0 clethodim + fenoxaprop-p-ethyl (50.0 + 50.0, fomesafen (225.0, lactofen (168.0, and nicosulfuron (50.0, and a no-herbicide control was included. The seedlings of both types of trees were transplanted into 3.1-L plastic containers. In the first study, herbicide was applied to Alexander palm seedlings of 25–30 cm in height. In the second study, herbicide was applied to Alexander palm seedlings of 30–40 cm in height. Herbicide was applied to peach palm tree seedlings of 40–55 cm in height in both studies. In peach palms only, the herbicides caused slight visible damage during early development. Collectively, the results suggested that all herbicides used are selective and can be used on peach palms during the various stages of development when there are one to four leaves. For Alexander palms, fluazifop-p-butyl, quizalofop-p-ethyl, and lactofen were the only herbicides that did not affect early development during the stages when the plant had one to four leaves.

  12. FIVE UNPUBLISHED COINS OF ALEXANDER THE GREAT AND HIS SUCCESSORS IN THE RHODES UNIVERSITY COLLECTION

    OpenAIRE

    J.D. Snowball; W.D. Snowball

    2012-01-01

    The article briefly discusses the economic and political significance of the Alexander III (“the Great”) type silver tetradrachm and publishes three of his coins currently held by the Rhodes University Classics Museum. Based on stylistic elements, they are classified as from the Amphipolis and Arados mints and were probably minted during his lifetime. Two further tetradrachms from the empires of Alexander’s successors, Ptolemy II and Seleucus IV, are also published.

  13. The impact of the alexander technique on improving posture and surgical ergonomics during minimally invasive surgery: pilot study.

    Science.gov (United States)

    Reddy, Pramod P; Reddy, Trisha P; Roig-Francoli, Jennifer; Cone, Lois; Sivan, Bezalel; DeFoor, W Robert; Gaitonde, Krishnanath; Noh, Paul H

    2011-10-01

    One of the main ergonomic challenges during surgical procedures is surgeon posture. There have been reports of a high number of work related injuries in laparoscopic surgeons. The Alexander technique is a process of psychophysical reeducation of the body to improve postural balance and coordination, permitting movement with minimal strain and maximum ease. We evaluated the efficacy of the Alexander technique in improving posture and surgical ergonomics during minimally invasive surgery. We performed a prospective cohort study in which subjects served as their own controls. Informed consent was obtained. Before Alexander technique instruction/intervention subjects underwent assessment of postural coordination and basic laparoscopic skills. All subjects were educated about the Alexander technique and underwent post-instruction/intervention assessment of posture and laparoscopic skills. Subjective and objective data obtained before and after instruction/intervention were tabulated and analyzed for statistical significance. All 7 subjects completed the study. Subjects showed improved ergonomics and improved ability to complete FLS™ as well as subjective improvement in overall posture. The Alexander technique training program resulted in a significant improvement in posture. Improved surgical ergonomics, endurance and posture decrease surgical fatigue and the incidence of repetitive stress injuries to laparoscopic surgeons. Further studies of the influence of the Alexander technique on surgical posture, minimally invasive surgery ergonomics and open surgical techniques are warranted to explore and validate the benefits for surgeons. Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  14. [A case of Alexander disease suspected juvenile-onset and exacerbating after long stationary state].

    Science.gov (United States)

    Nagaishi, Akiko; Nakane, Shunya; Fukudome, Takayasu; Matsuo, Hidenori; Yoshida, Tomokatsu

    2013-01-01

    We report the case of a 40-year-old woman with Alexander disease. She experienced single seizure as 1-year-old, and became less active after that. Her academic records in elementary school were poor. However, she graduated from junior college and was later employed as a clerk for a short duration. Her parents, who lived with her noticed her apathy when she was 38, and gait disturbance soon after. At the age of 40, she was admitted to a hospital because of a fall and was referred to us. Brain magnetic resonance imaging (MRI) showed significant leukodystrophy with frontal predominance, and cervical MRI revealed mild cervical cord atrophy with dilated central canal. We performed genetic analysis and found the R79H variant of the gene encoding the glial fibrillary acidic protein. The patient was diagnosed with Alexander disease and suspedted juvenile-onset on the basis of the genetic analysis and MRI findings. Patients with juvenile Alexander disease have been previously reported to have variable survival, ranging from the early teens to the 20's and 30's. Our patient may suggest that natural history of this disease is more variable than previously thought.

  15. Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.

    Science.gov (United States)

    LaPash Daniels, Christine M; Paffenroth, Elizabeth; Austin, Elizabeth V; Glebov, Konstantin; Lewis, Diana; Walter, Jochen; Messing, Albee

    2015-01-01

    Alexander disease is a fatal neurodegenerative disease caused by mutations in the astrocyte intermediate filament glial fibrillary acidic protein (GFAP). The disease is characterized by elevated levels of GFAP and the formation of protein aggregates, known as Rosenthal fibers, within astrocytes. Lithium has previously been shown to decrease protein aggregates by increasing the autophagy pathway for protein degradation. In addition, lithium has also been reported to decrease activation of the transcription factor STAT3, which is a regulator of GFAP transcription and astrogliogenesis. Here we tested whether lithium treatment would decrease levels of GFAP in a mouse model of Alexander disease. Mice with the Gfap-R236H point mutation were fed lithium food pellets for 4 to 8 weeks. Four weeks of treatment with LiCl at 0.5% in food pellets decreased GFAP protein and transcripts in several brain regions, although with mild side effects and some mortality. Extending the duration of treatment to 8 weeks resulted in higher mortality, and again with a decrease in GFAP in the surviving animals. Indicators of autophagy, such as LC3, were not increased, suggesting that lithium may decrease levels of GFAP through other pathways. Lithium reduced the levels of phosphorylated STAT3, suggesting this as one pathway mediating the effects on GFAP. In conclusion, lithium has the potential to decrease GFAP levels in Alexander disease, but with a narrow therapeutic window separating efficacy and toxicity.

  16. Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease

    Science.gov (United States)

    LaPash Daniels, Christine M.; Paffenroth, Elizabeth; Austin, Elizabeth V.; Glebov, Konstantin; Lewis, Diana; Walter, Jochen; Messing, Albee

    2015-01-01

    Alexander disease is a fatal neurodegenerative disease caused by mutations in the astrocyte intermediate filament glial fibrillary acidic protein (GFAP). The disease is characterized by elevated levels of GFAP and the formation of protein aggregates, known as Rosenthal fibers, within astrocytes. Lithium has previously been shown to decrease protein aggregates by increasing the autophagy pathway for protein degradation. In addition, lithium has also been reported to decrease activation of the transcription factor STAT3, which is a regulator of GFAP transcription and astrogliogenesis. Here we tested whether lithium treatment would decrease levels of GFAP in a mouse model of Alexander disease. Mice with the Gfap-R236H point mutation were fed lithium food pellets for 4 to 8 weeks. Four weeks of treatment with LiCl at 0.5% in food pellets decreased GFAP protein and transcripts in several brain regions, although with mild side effects and some mortality. Extending the duration of treatment to 8 weeks resulted in higher mortality, and again with a decrease in GFAP in the surviving animals. Indicators of autophagy, such as LC3, were not increased, suggesting that lithium may decrease levels of GFAP through other pathways. Lithium reduced the levels of phosphorylated STAT3, suggesting this as one pathway mediating the effects on GFAP. In conclusion, lithium has the potential to decrease GFAP levels in Alexander disease, but with a narrow therapeutic window separating efficacy and toxicity. PMID:26378915

  17. History and Pre-History of the Alexander von Humboldt Foundation

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    D. Platikanov

    2014-02-01

    Full Text Available In this paper a short review of the history of Alexander von Humboldt Foundation, Bonn - Bad Godesberg, Germany, on the occasion of its 60th anniversary is presented. This outstanding German foundation is actually the third one with the same name. Earlier two other Alexander von Humboldt Foundations consequently existed and they consist its pre-history, which is also shortly reviewed. The establishment of the present Foundation in 1953, its development and growth, its activities, information about the six presidents and five executive directors, as well as the main features, principles and guidelines are considered. During the last 60 years the Alexander von Humboldt Foundation became an important institution for the promotion of international research cooperation, which significantly influences the world science. It supported more than 27700 Humboldt fellows to carry out scientific research in Germany, and they form a large Humboldt family: a world-wide network. Large number Bulgarian Humboldt fellows are among the best scientists in Bulgaria.

  18. [Neurology in Byzantine medicine. An analysis of Alexander of Tralles' Medici libri duodecim].

    Science.gov (United States)

    de Frutos-Gonzalez, Virgina; Guerrero-Peral, Ángel L

    2010-10-01

    Byzantium continued Greek and Roman habit of texts compilation, and so, preserved medical knowledge. In addition, assimilating the influence of Monastic and Arabic medicine, Byzantine physicians transmitted original contributions including references to neurological diseases. Alexander of Tralles was one of major exponents of Byzantine medicine. He received his early medical training with his father, and in extensive travels, gathered medical knowledge and experience. Medici libri duodecim is a treatise on pathology and therapeutics of internal diseases, in twelve books. It comprises views from observation of different diseases. Its influence was prolonged and it was translated and edited until Renaissance. We analyze grecolatin edition by Henricum Petrum (1556), with special interest in neurological disease citations. DEVELOPMENT. First of twelve books is dedicated to head and brain diseases. When considering headache, he classifies them, following Aretaeus of Cappadocia, in cephalalgia, cephalea and hemicrania, suggesting different pathogenic mechanisms and therapies. Headache is included among symptoms conducting, as well as memory or sleep disturbances, to delirium. Medici libri duodecim considers memory complaints among systemic diseases, mainly with cardiac involvement. Alexander distinguishes between paralysis (privation of sensibility and mobility concerning half of the body), and apoplexy (including main soul functions loss, even conducting to death). Regarding epilepsy, Medici libri duodecim considers that its origin can be outside the head, mainly in the stomach, and offers us descriptions of epileptic auras. Analysis of Alexander of Tralles' Medici libri duodecim shows how byzantine physicians understood neurological diseases. Therapeutics was based on venesection, medicinal plants and avoidance of noxious substances.

  19. Teachers' professional development needs and current practices at the Alexander Science Center School

    Science.gov (United States)

    Gargus, Gerald Vincent

    This investigation represents an in-depth understanding of teacher professional development at the Alexander Science Center School, a dependent charter museum school established through a partnership between the California Science Center and Los Angeles Unified School District. Three methods of data collection were used. A survey was distributed and collected from the school's teachers, resulting in a prioritized list of teacher professional development needs, as well as a summary of teachers' opinions about the school's existing professional development program. In addition, six key stakeholders in the school's professional development program were interviewed for the study. Finally, documents related to the school's professional development program were analyzed. Data collected from the interviews and documents were used to develop an understand various components of the Alexander Science Center School's professional development program. Teachers identified seven areas that had a high-priority for future professional development including developing skills far working with below-grade-level students, improving the analytical skills of student in mathematics, working with English Language Learners, improving students' overall reading ability levels, developing teachers' content-area knowledge for science, integrating science across the curriculum, and incorporating hands-on activity-based learning strategies to teach science. Professional development needs identified by Alexander Science Center School teachers were categorized based on their focus on content knowledge, pedagogical content knowledge, or curricular knowledge. Analysis of data collected through interviews and documents revealed that the Alexander Science Center School's professional development program consisted of six venues for providing professional development for teachers including weekly "banked time" sessions taking place within the standard school day, grade-level meetings, teacher support

  20. Alexander Fleming, citrated blood and penicillin: paths not pursued and applications delayed.

    Science.gov (United States)

    Mortimer, P P

    2009-12-01

    Ninety years ago Alexander Fleming (later to discover penicillin) jointly wrote a description of the use of indirect transfusions of citrated blood at a World War 1 (WW1) base hospital. It was the longest series yet to be published, incorporating what was then a novel procedure for treating war casualties. Returning to civilian life Fleming, a qualified surgeon and bacteriologist, chose a different career path, and not until the wars of the late 1930s were the advances in transfusion in WW1 fully incorporated into the management of trauma and haemorrhage. Like penicillin, the benefits of indirect transfusion were only slowly realised.

  1. Das Ganze der Natur Alexander von Humboldt und das romantische Forschungsprogramm

    Directory of Open Access Journals (Sweden)

    Kristian Köchy

    2002-10-01

    Full Text Available Article in German, Abstracts in English, German and Spanish. The wholeness of natureAlexander von Humboldt and the romantic research programIt does not seem to be clear whether there is a tight junction between the humboldian science and the romantic research program. But by recognizing the principal aim of Humboldts concept – the representation of nature as a whole – one can see how Humboldts view has been developed in contact with romantic ideas. This investigation analyses Humboldts research program in consideration of its main features and the special relations between science, philosophy of nature, feeling of nature, history and art.

  2. Familial Adult-onset Alexander Disease: Clinical and Neuroradiological Findings of Three Cases.

    Science.gov (United States)

    Elmali, Ayşe Deniz; Çetinçelik, Ümran; Işlak, Civan; Uzun Adatepe, Nurten; Karaali Savrun, Feray; Yalçinkaya, Cengiz

    2016-06-01

    The adult-onset Alexander disease (AOAD) dramatically differs from the early onset AD with respect to clinical and neuroradiological findings. Herein we report the detailed clinical and neuroradiological findings of a Turkish family with AOAD. In all three cases, magnetic resonance imaging revealed marked atrophy of the mesencephalon, bulbus, and cervical spinal cord accompanied with signal abnormalities in the same regions along with supratentorial white matter. Basal ganglia were affected in two cases. Molecular genetic analysis revealed heterozygous mutation in the 8th exon of the glial fibrillary acidic protein gene M451I (c.1245G>A), leading to the diagnosis of AOAD in all cases.

  3. PRAYER AND THE "SPIRITUAL CONSTITUENT" IN THE IMAGE OF A BELOVED IN ALEXANDER PUSHKIN'S LYRIC POETRY

    OpenAIRE

    Elena Alexandrovna Kuchina

    2013-01-01

    Prayer in Alexander Pushkin's lyric poetry appears in its natural ecclesiological context. In his prayerful poems devoted to a woman the motif of turning Love into Divinity in the light of Christian understanding of Beauty plays the most important role. Pushkin's personal prayers are very close to the patristic idea. In his poem Akathist to Ekaterina Nikolaevna Karamzina Pushkin embodied the prayer-praising; in his poem I loved you — and love it may yet be Deep in my soul... he embodied the p...

  4. Alexander Thom (1775-1845): From Army Surgeon to Settlement Founder.

    Science.gov (United States)

    Petty, Ross D

    2017-01-01

    This paper examines the life of a 19th century medical practitioner and the impact he had on both people and society. Alexander Thom had a distinguished career as a surgeon in the British Army Medical Service before retiring to become one of the founding settlers and leaders of Perth, Ontario. There his half-pay retirement, land grants from being in the military and his medical practice enabled him to become a successful businessman-mill owner, justice of the peace, local politician and eventually district court judge. Like many doctors of his or any era, his contributions to society extended beyond his medical practice.

  5. Comparative-historical method in Slavic linguistics and Alexander Vostokov’s philological intuitions

    OpenAIRE

    Melkov Andrey Sergeevich

    2015-01-01

    The article is devoted to the estimation of Alexander Vostokov’s (1781-1864) contribution to the formation and development of the Slavic philology as a scientific discipline. In the foundation of the research there is the analyses of Vostokov’s work “Judgement about the Slavic language”, which has become the result of the scientist’s study the oldest Russian manuscript “Ostromir Gospels”. Vostokov devised a new method for the Slavic philology, which is used to call comparative-historical in m...

  6. "Die Toten reiten schnelle." Literarische Zitate in Briefen von und an Alexander von Humboldt

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    Ingo Schwarz

    2007-04-01

    Full Text Available Article in GermanAbstract in English and GermanAlexander von Humboldt and his correspondents liked to enrich or embellish their letters with quotations from classic works of ancient literature as well as from recent poems, plays, or novels. This paper tries to show that references to literature were very often used in order to express thoughts and feelings more clearly not so much for impressing the recipients of letters with high education. In educated circles a good knowledge of ancient and modern works of literature was a standard requirement, which often allowed the letter writers to use quotations in a playful manner.

  7. Rar o koshmare ili intervju, kotorogo ne bõlo / Alexander Rahr ; interv. Jana Toom

    Index Scriptorium Estoniae

    Rahr, Alexander

    2008-01-01

    Tallinnas toimus 2007. a. aprillisündmustele pühendatud V Kodurahu foorum. Esinejate hulgas oli ka tuntud Saksa politoloog Alexander Rahr, kes Eestisse saabus loenguga teemal "Saksamaa-Venemaa: strateegilise partnerluse ülesehitamise kogemused". Lääneriigid on veendunud, et NATO ja Euroopa Liidu laienemine tugevdab ja konsolideerib demokraatlikku Euroopat, kuid Venemaad uude Euroopasse mitteintegreerides teeb Lääs strateegilise vea, mille eest tasumine jääb järgnevatele põlvedele. Kahjuks aitab eneseisolatsioonile kaasa ka Moskva tegevus. Euroopa ühise kodu idee, vanade ja uute Euroopa Liidu liikmete suhted Venemaaga, teemad, mis vajaksid kogu Euroopa koostööd

  8. The ocular motor features of adult-onset alexander disease: a case and review of the literature.

    Science.gov (United States)

    Pfeffer, Gerald; Abegg, Mathias; Vertinsky, A Talia; Ceccherini, Isabella; Caroli, Francesco; Barton, Jason J S

    2011-06-01

    A 51-year-old Chinese man presented with gaze-evoked nystagmus, impaired smooth pursuit and vestibular ocular reflex cancellation, and saccadic dysmetria, along with a family history suggestive of late-onset autosomal dominant parkinsonism. MRI revealed abnormalities of the medulla and cervical spinal cord typical of adult-onset Alexander disease, and genetic testing showed homozygosity for the p.D295N polymorphic allele in the gene encoding the glial fibrillary acidic protein. A review of the literature shows that ocular signs are frequent in adult-onset Alexander disease, most commonly gaze-evoked nystagmus, pendular nystagmus, and/or oculopalatal myoclonus, and less commonly ptosis, miosis, and saccadic dysmetria. These signs are consistent with the propensity of adult-onset Alexander disease to cause medullary abnormalities on neuroimaging.

  9. Can the Alexander Technique improve balance and mobility in older adults with visual impairments? A randomized controlled trial.

    Science.gov (United States)

    Gleeson, Michael; Sherrington, Catherine; Lo, Serigne; Keay, Lisa

    2015-03-01

    To investigate the impact of Alexander Technique lessons on balance and mobility in older adults with visual impairments. Randomized assessor blinded controlled trial with intervention and usual care control groups. Participants' homes. A total of 120 community-dwellers aged 50+ with visual impairments. Twelve weeks of Alexander lessons and usual care. Short Physical Performance Battery items were primary outcomes at 3 months and secondary outcomes at 12 months. Additional secondary outcomes were postural sway, maximal balance range and falls over 12 months. Between-group differences in primary outcomes were not significant. The intervention group reduced postural sway on a firm surface with eyes open at 3 months after adjusting for baseline values (-29.59 mm, 95%CI -49.52 to -9.67, P Alexander Technique is warranted. © The Author(s) 2014.

  10. Randomised controlled trial of Alexander technique lessons, exercise, and massage (ATEAM) for chronic and recurrent back pain.

    Science.gov (United States)

    Little, Paul; Lewith, George; Webley, Fran; Evans, Maggie; Beattie, Angela; Middleton, Karen; Barnett, Jane; Ballard, Kathleen; Oxford, Frances; Smith, Peter; Yardley, Lucy; Hollinghurst, Sandra; Sharp, Debbie

    2008-12-01

    To determine the effectiveness of lessons in the Alexander technique, massage therapy, and advice from a doctor to take exercise (exercise prescription) along with nurse delivered behavioural counselling for patients with chronic or recurrent back pain. Factorial randomised trial. Setting 64 general practices in England. 579 patients with chronic or recurrent low back pain; 144 were randomised to normal care, 147 to massage, 144 to six Alexander technique lessons, and 144 to 24 Alexander technique lessons; half of each of these groups were randomised to exercise prescription. Normal care (control), six sessions of massage, six or 24 lessons on the Alexander technique, and prescription for exercise from a doctor with nurse delivered behavioural counselling. Roland Morris disability score (number of activities impaired by pain) and number of days in pain. Exercise and lessons in the Alexander technique, but not massage, remained effective at one year (compared with control Roland disability score 8.1: massage -0.58, 95% confidence interval -1.94 to 0.77, six lessons -1.40, -2.77 to -0.03, 24 lessons -3.4, -4.76 to -2.03, and exercise -1.29, -2.25 to -0.34). Exercise after six lessons achieved 72% of the effect of 24 lessons alone (Roland disability score -2.98 and -4.14, respectively). Number of days with back pain in the past four weeks were lower after lessons (compared with control median 21 days: 24 lessons -18, six lessons -10, massage -7) and quality of life improved significantly. No significant harms were reported. One to one lessons in the Alexander technique from registered teachers have long term benefits for patients with chronic back pain. Six lessons followed by exercise prescription were nearly as effective as 24 lessons.

  11. An economic evaluation of Alexander Technique lessons or acupuncture sessions for patients with chronic neck pain: A randomized trial (ATLAS).

    Science.gov (United States)

    Essex, Holly; Parrott, Steve; Atkin, Karl; Ballard, Kathleen; Bland, Martin; Eldred, Janet; Hewitt, Catherine; Hopton, Ann; Keding, Ada; Lansdown, Harriet; Richmond, Stewart; Tilbrook, Helen; Torgerson, David; Watt, Ian; Wenham, Aniela; Woodman, Julia; MacPherson, Hugh

    2017-01-01

    To assess the cost-effectiveness of acupuncture and usual care, and Alexander Technique lessons and usual care, compared with usual GP care alone for chronic neck pain patients. An economic evaluation was undertaken alongside the ATLAS trial, taking both NHS and wider societal viewpoints. Participants were offered up to twelve acupuncture sessions or twenty Alexander lessons (equivalent overall contact time). Costs were in pounds sterling. Effectiveness was measured using the generic EQ-5D to calculate quality adjusted life years (QALYs), as well as using a specific neck pain measure-the Northwick Park Neck Pain Questionnaire (NPQ). In the base case analysis, incremental QALY gains were 0.032 and 0.025 in the acupuncture and Alexander groups, respectively, in comparison to usual GP care, indicating moderate health benefits for both interventions. Incremental costs were £451 for acupuncture and £667 for Alexander, mainly driven by intervention costs. Acupuncture was likely to be cost-effective (ICER = £18,767/QALY bootstrapped 95% CI £4,426 to £74,562) and was robust to most sensitivity analyses. Alexander lessons were not cost-effective at the lower NICE threshold of £20,000/QALY (£25,101/QALY bootstrapped 95% CI -£150,208 to £248,697) but may be at £30,000/QALY, however, there was considerable statistical uncertainty in all tested scenarios. In comparison with usual care, acupuncture is likely to be cost-effective for chronic neck pain, whereas, largely due to higher intervention costs, Alexander lessons are unlikely to be cost-effective. However, there were high levels of missing data and further research is needed to assess the long-term cost-effectiveness of these interventions.

  12. Evidence for the effectiveness of Alexander Technique lessons in medical and health-related conditions: a systematic review.

    Science.gov (United States)

    Woodman, J P; Moore, N R

    2012-01-01

    Complementary medicine and alternative approaches to chronic and intractable health conditions are increasingly being used, and require critical evaluation. The aim of this review was to systematically evaluate available evidence for the effectiveness and safety of instruction in the Alexander Technique in health-related conditions. PUBMED, EMBASE, PSYCHINFO, ISI Web-of-Knowledge, AMED, CINHAL-plus, Cochrane library and Evidence-based Medicine Reviews were searched to July 2011. Inclusion criteria were prospective studies evaluating Alexander Technique instruction (individual lessons or group delivery) as an intervention for any medical indication/health-related condition. Studies were categorised and data extracted on study population, randomisation method, nature of intervention and control, practitioner characteristics, validity and reliability of outcome measures, completeness of follow-up and statistical analyses.   Of 271 publications identified, 18 were selected: three randomised, controlled trials (RCTs), two controlled non-randomised studies, eight non-controlled studies, four qualitative analyses and one health economic analysis. One well-designed, well-conducted RCT demonstrated that, compared with usual GP care, Alexander Technique lessons led to significant long-term reductions in back pain and incapacity caused by chronic back pain. The results were broadly supported by a smaller, earlier RCT in chronic back pain. The third RCT, a small, well-designed, well-conducted study in individuals with Parkinson's disease, showed a sustained increased ability to carry out everyday activities following Alexander lessons, compared with usual care. The 15 non-RCT studies are also reviewed. Strong evidence exists for the effectiveness of Alexander Technique lessons for chronic back pain and moderate evidence in Parkinson's-associated disability. Preliminary evidence suggests that Alexander Technique lessons may lead to improvements in balance skills in the

  13. Efficacy of the Alexander Technique in treating chronic non-specific neck pain: a randomized controlled trial.

    Science.gov (United States)

    Lauche, Romy; Schuth, Mareike; Schwickert, Myriam; Lüdtke, Rainer; Musial, Frauke; Michalsen, Andreas; Dobos, Gustav; Choi, Kyung-Eun

    2016-03-01

    To test the efficacy of the Alexander Technique, local heat and guided imagery on pain and quality of life in patients with chronic non-specific neck pain. A randomized controlled trial with 3 parallel groups was conducted. Outpatient clinic, Department of Internal and Integrative Medicine. A total of 72 patients (65 females, 40.7±7.9 years) with chronic non-specific neck pain. Patients received 5 sessions of the Alexander Technique--an educational method which aims to modify dysfunctional posture, movement and thinking patterns associated with musculoskeletal disorders. Control groups were treated with local heat application or guided imagery. All interventions were conducted once a week for 45 minutes each. The primary outcome measure at week 5 was neck pain intensity on a 100-mm visual analogue scale; secondary outcomes included neck disability, quality of life, satisfaction and safety. Analyses of covariance were applied; testing ordered hypotheses. No group difference was found for pain intensity for the Alexander Technique compared to local heat (difference 4.5mm; 95% CI:-8.1;17.1; p=0.48), but exploratory analysis revealed the superiority of the Alexander Technique over guided imagery (difference -12.9 mm; 95% CI:-22.6;-3.1, p=0.01). Significant group differences in favor of the Alexander Technique were also found for physical quality of life (P<0.05). Adverse events mainly included slightly increased pain and muscle soreness. The Alexander Technique was not superior to local heat application in treating chronic non-specific neck pain. It cannot be recommended as routine intervention at this time. Further trials are warranted for conclusive judgment. © The Author(s) 2015.

  14. Beneficial effects of Nrf2 overexpression in a mouse model of Alexander disease.

    Science.gov (United States)

    LaPash Daniels, Christine M; Austin, Elizabeth V; Rockney, Danica E; Jacka, Elizabeth M; Hagemann, Tracy L; Johnson, Delinda A; Johnson, Jeffrey A; Messing, Albee

    2012-08-01

    Alexander disease is a fatal neurodegenerative disease caused by dominant mutations in glial fibrillary acidic protein (GFAP). The disease is characterized by protein inclusions called Rosenthal fibers within astrocyte cell bodies and processes, and an antioxidant response mediated by the transcription factor Nrf2. We sought to test whether further elevation of Nrf2 would be beneficial in a mouse model of Alexander disease. Forcing overexpression of Nrf2 in astrocytes of R236H GFAP mutant mice decreased GFAP protein in all brain regions examined (olfactory bulb, hippocampus, cerebral cortex, brainstem, cerebellum, and spinal cord) and decreased Rosenthal fibers in olfactory bulb, hippocampus, corpus callosum, and brainstem. Nrf2 overexpression also restored body weights of R236H mice to near wild-type levels. Nrf2 regulates several genes involved in homeostasis of the antioxidant molecule glutathione, and the neuroprotective effects of Nrf2 in other neurological disorders may reflect restoration of glutathione to normal levels. However, glutathione levels in R236H mice were not decreased. Nrf2 overexpression did not change glutathione levels or ratio of reduced to oxidized glutathione (indicative of oxidative stress) in olfactory bulb, where Nrf2 dramatically reduced GFAP. Depletion of glutathione through knock-out of the GCLM (glutamate-cysteine ligase modifier subunit) also did not affect GFAP levels or body weight of R236H mice. These data suggest that the beneficial effects of Nrf2 are not mediated through glutathione.

  15. The clinical spectrum of late-onset Alexander disease: a systematic literature review.

    Science.gov (United States)

    Balbi, Pietro; Salvini, Silvana; Fundarò, Cira; Frazzitta, Giuseppe; Maestri, Roberto; Mosah, Dibo; Uggetti, Carla; Sechi, GianPietro

    2010-12-01

    Following the discovery of glial fibrillary acidic protein (GFAP) mutations as the causative factor of Alexander disease (AxD), new case reports have recently increased, prompting a more detailed comprehension of the clinical features of the three disease subtypes (infantile, juvenile and adult). While the clinical pattern of the infantile form has been substantially confirmed, the late-onset subtypes (i.e., juvenile and adult), once considered rare manifestations of AxD, have displayed a wider clinical spectrum. Our aim was to evaluate the clinical phenotype of the adult and juvenile forms by reviewing the previously reported cases. Data were collected from previously published reports on 112 subjects affected by neuropathologically or genetically proven adult and juvenile Alexander disease. Although the late-onset forms of AxD show a wide clinical variability, a common pattern emerges from comparing previously reported cases, characterized by pseudo-bulbar signs, ataxia, and spasticity, associated with atrophy of the medulla and upper cervical cord on neuroimaging. Late-onset AxD cases can no longer be considered as rare manifestations of the disease. The clinical pattern usually reflects the topographic localization of the lesions, with adult cases displaying a predominant infratentorial localization of the lesions. Juvenile cases show clinical and radiological features which are intermediate between adult and infantile forms.

  16. Effects of Implementing the Alexander Technique on Enjoying the Sense of Motherhood in the Postpartum Period.

    Science.gov (United States)

    Banoofatemeh, Somayeh; Oreyzi, Hamid Reza; Bahadoran, Parvin

    2017-01-01

    The broad concept of maternal well-being includes psychological concepts, social aspects, and aspects of becoming a mother. The present study aimed to investigate the effects of implementing the Alexander technique on enjoying the sense of motherhood. This study was a clinical trial conducted in two phases. In the first phase, using the exploratory and confirmatory factor analysis, 226 mothers were asked to undergo a scale test of enjoying the sense of motherhood after childbirth. In the second phase, 88 pregnant women were divided into two experimental groups. The data collection tool was a researcher-made questionnaire about enjoying the sense of motherhood. Independent samples t-test, Mann-Whitney test, Chi-square test, Fisher's exact test, analysis of variance test, Box test, and Levine test were used to analyze the data. Results of this study showed that the mean scores of the constructs of enjoying pregnancy (P > 0.001), motherhood, and child care satisfaction (P > 0.001) in the experimental group were significantly higher than the control group. Moreover, the construct of trusting their own abilities to cope with maternal duties (P > 0.01) did not show significant differences between the two groups. The findings indicated that the Alexander technique can promote mothers' psychological well-being and their pleasure of becoming a mother and the related constructs. Results also revealed that using this technique, educating and recommending pregnant women to use this technique will be beneficial.

  17. Identität und Differenz Goethes Faust und Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Heinz Krumpel

    2007-04-01

    Full Text Available Article in German, Abstracts in English, Spanish and GermanIn the article “Identity and difference between Goethe`s Faust and Alexander von Humboldt” the issue of how much Faust is contained in Humboldt and in which way Goethe`s Faust has to be related to Alexander von Humboldt is discussed. Here the connection of activity, knowledge and vision as well as the relationship between humans and nature are central to the examination. Goethe and Humboldt were greatly influenced by the enlightenment. Their ideas and visions show us today that modernity is an incomplete project. In Goethe`s Faust the question of the essence of mankind is posed because there is a hint of Faust and Mephisto in each human. With Humboldt those principles acted among other things as a driving force for greater productitivity and the extraction of knowledge. Even though Faust did not fail in his bet with Mephisto, on the other hand he also did not win. Humboldt, however, would have won the bet. Considering the global ecological crisis and regional conflicts today the idea of the relation of Goethe´s Faust and Humboldt has an astonishing relevance.

  18. Pamphlet of the Arethas of Caesarea Against Nicholas Mysticus and Emperor Alexander I

    Directory of Open Access Journals (Sweden)

    Dmitriy E. Afinogenov

    2017-11-01

    Full Text Available Using the demise of ex-Patriarch Euthymios (date of death – August 5, 917 as a pretext, Arethas of Caesarea attacks with vicious blame both deceased Emperor Alexander I and prospering and ruling Patriarch Nicholas Mysticus. The article proposes to date the Funerary oration on Euthymios (BHG 652 to August 917, since it was apparently pronounced on occasion of his death and funeral, not on the relics transfer, as it was supposed before. The author analyzes the famous comparison of Euthymios with John Chrysostom, Nikephoros I of Constantinople, and with Photios. Actually, it was Emperor Leo VI who removed Photios and sent him to exile (or relegated to a monastery. This fact classes Euthymios with Arcadius and Eudoxia, and most importantly with image breaker Leo V. This circumstance casts serious doubts on Arethas’ motivations. The reason for the positive attitude towards Leo could be, apart from the opposition to Alexander, the fact that at the time of the work’s composition Zoe Carbonopsina was the actual regent, who ruled in the name of Leo VI’s minor son Constantine VII. The publication contains a Russian translation of the work, the first version in any modern European language ever.

  19. Trace element analysis of Alexander the Great's silver tetradrachms minted in Macedonia

    Science.gov (United States)

    Kallithrakas-Kontos, N.; Katsanos, A. A.; Touratsoglou, J.

    2000-11-01

    The coinage of Alexander the Great presents a special interest because of its international character in the frame of the ancient times. At least 31 mints (from Aigai to Babylon and from Pella to Alexandreia) operated in the vast state, which was created by Alexander in just over 10 years (334-323 BC). Impressive quantities of tetradrachms were consequently minted for the economic affairs of an expanding state. The mints continued to be active and after the premature death of the Macedonian king, producing among others and tetradrachms in his name. The elemental chemical composition of silver tetradrachms minted in Amphipolis as well as in other Macedonian Greek cities was analysed by energy dispersive X-ray fluorescence (EDXRF), and 12 elements were determined. The problem of the patina (silver corrosion layer) effects on the results was examined by analysis before and after the corrosion product removal. From the results of the chemical composition, a similar numismatic policy is deduced for all the analysed coin as well as metal provenance indications for some of the coins.

  20. Book review: An Introduction to Audio Content Analysis: Applications in Signal Processing and Music Informatics by Alexander Lerch

    DEFF Research Database (Denmark)

    Sturm, Bob L.

    2013-01-01

    A critical review of the book: An Introduction to Audio Content Analysis: Applications in Signal Processing and Music Informatics, by Alexander Lerch, October 2012, Wiley-IEEE Press. ISBN: 978-1-118-26682-3, Hardcover, 272 pages, 503 references. List price $125.00......A critical review of the book: An Introduction to Audio Content Analysis: Applications in Signal Processing and Music Informatics, by Alexander Lerch, October 2012, Wiley-IEEE Press. ISBN: 978-1-118-26682-3, Hardcover, 272 pages, 503 references. List price $125.00...

  1. Infantile-onset Alexander disease: a genetically proven case with mild clinical course in a 6-year-old Indian boy.

    Science.gov (United States)

    Ramesh, Konanki; Sharma, Suvasini; Kumar, Atin; Salomons, Gajja S; van der Knaap, Marjo S; Gulati, Sheffali

    2013-03-01

    Alexander disease is an autosomal dominant leukoencephalopathy characterized by developmental delay, macrocephaly, and characteristic neuroimaging abnormalities predominantly involving frontal lobes. We report a 6-year-old Indian boy with infantile-onset Alexander disease, who has an unusually mild clinical course and a de novo p.Leu359Val mutation in the glial fibrillary acidic protein gene.

  2. Patients' views of receiving lessons in the Alexander technique and an exercise prescription for managing back pain in the ATEAM trial.

    Science.gov (United States)

    Yardley, Lucy; Dennison, Laura; Coker, Rebecca; Webley, Frances; Middleton, Karen; Barnett, Jane; Beattie, Angela; Evans, Maggie; Smith, Peter; Little, Paul

    2010-04-01

    Lessons in the Alexander Technique and exercise prescription proved effective for managing low back pain in primary care in a clinical trial. To understand trial participants' expectations and experiences of the Alexander Technique and exercise prescription. A questionnaire assessing attitudes to the intervention, based on the Theory of Planned Behaviour, was completed at baseline and 3-month follow-up by 183 people assigned to lessons in the Alexander Technique and 176 people assigned to exercise prescription. Semi-structured interviews to assess the beliefs contributing to attitudes to the intervention were carried out at baseline with14 people assigned to the lessons in the Alexander Technique and 16 to exercise prescription, and at follow-up with 15 members of the baseline sample. Questionnaire responses indicated that attitudes to both interventions were positive at baseline but became more positive at follow-up only in those assigned to lessons in the Alexander Technique. Thematic analysis of the interviews suggested that at follow-up many patients who had learned the Alexander Technique felt they could manage back pain better. Whereas many obstacles to exercising were reported, few barriers to learning the Alexander Technique were described, since it 'made sense', could be practiced while carrying out everyday activities or relaxing, and the teachers provided personal advice and support. Using the Alexander Technique was viewed as effective by most patients. Acceptability may have been superior to exercise because of a convincing rationale and social support and a better perceived fit with the patient's particular symptoms and lifestyle.

  3. Speciation despite globally overlapping distributions in Penicillium chrysogenum: the population genetics of Alexander Fleming’s lucky fungus

    Science.gov (United States)

    Eighty years ago, Alexander Fleming described the antibiotic effects of a fungus that had contaminated his bacterial culture, kick starting the antimicrobial revolution. The fungus was later ascribed to a globally distributed asexual species, Penicillium chrysogenum. Recently, the species has been...

  4. Reminescência da Guerra Fria: Alexander Haig (02-12-1924 a 20-02-2010

    Directory of Open Access Journals (Sweden)

    Virgílio Caixeta Arraes

    2010-03-01

    Full Text Available O artigo biografa o General Alexander Haig, figura de destaque na gestão de Richard Nixon e Ronald Reagan. Descreve a ambição do militar em ser ele mesmo Presidente dos Estados Unidos.

  5. Reminescência da Guerra Fria: Alexander Haig (02-12-1924 a 20-02-2010

    Directory of Open Access Journals (Sweden)

    Virgílio Caixeta Arraes

    2010-06-01

    Full Text Available O artigo biografa o General Alexander Haig, figura de destaque na gestão de Richard Nixon e Ronald Reagan. Descreve a ambição do militar em ser ele mesmo Presidente dos Estados Unidos.

  6. Brookhaven Lab physicists Edward Beebe and Alexander Pikin win 'Brightness Award' for achievement in ion source physics and technology

    CERN Multimedia

    2003-01-01

    "Edward Beebe and Alexander Pikin, physicists at the U.S. Department of Energy's Brookhaven National Laboratory, have been awarded the Ion Source Prize, known as the "Brightness Award," which recognizes and encourages innovative and significant recent achievements in the fields of ion source physics and technology" (1 page).

  7. Alexander Claver, Dutch Commerce and Chinese Merchants in Java. Colonial Relationships in Trade and Finance, 1800-1942

    Directory of Open Access Journals (Sweden)

    Kwee Hui Kian

    2015-09-01

    Full Text Available Alexander Claver, Dutch Commerce and Chinese Merchants in Java. Colonial Relationships in Trade and Finance, 1800-1942 (Verhandelingen van het Koninklijk Instituut voor Taal-, Land- en Volkenkunde 291; Leiden, Boston: Brill, 2014, xxiv + 442 pp., ISBN 978 90 04 25657 6.

  8. Effects of traumatic brain injury on reactive astrogliosis and seizures in mouse models of Alexander disease.

    Science.gov (United States)

    Cotrina, Maria Luisa; Chen, Michael; Han, Xiaoning; Iliff, Jeffrey; Ren, Zeguang; Sun, Wei; Hagemann, Tracy; Goldman, James; Messing, Albee; Nedergaard, Maiken

    2014-09-25

    Alexander disease (AxD) is the only known human pathology caused by mutations in an astrocyte-specific gene, glial fibrillary acidic protein (GFAP). These mutations result in abnormal GFAP accumulations that promote seizures, motor delays and, ultimately, death. The exact contribution of increased, abnormal levels of astrocytic mutant GFAP in the development and progression of the epileptic phenotype is not clear, and we addressed this question using two mouse models of AxD. Comparison of brain seizure activity spontaneously and after traumatic brain injury (TBI), an effective way to trigger seizures, revealed that abnormal GFAP accumulation contributes to anomalous brain activity (increased non-convulsive hyperactivity) but is not a risk factor for the development of epilepsy after TBI. These data highlight the need to further explore the complex and heterogeneous response of astrocytes towards injury and the involvement of GFAP in the progression of AxD. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Unusual presentations and intrafamilial phenotypic variability in infantile onset Alexander disease.

    Science.gov (United States)

    Tonduti, Davide; Ardissone, Anna; Ceccherini, Isabella; Giaccone, Giorgio; Farina, Laura; Moroni, Isabella

    2016-06-01

    Alexander disease is an hereditary leukodystrophy related to mutations of GFAP. Classically AxD was divided in infantile, juvenile, and adult subgroups. Recent data suggested considering only two subtypes: type I (infantile onset with lesions extending to the cerebral hemispheres); type II (adult onset with primary involvement of subtentorial structures). We report two related and one unrelated patients presenting with a peculiar association of clinical and neuroradiological features. GFAP analysis disclosed the presence of one novel and two previously reported mutations. Our patients underline the importance of considering AxD in patients with bulbar symptoms and autonomic dysfunction even if MRI shows only posterior fossa abnormalities, supporting the hypothesis of a third type of AxD sharing features of both type I and type II. The evidence of an intrafamilial phenotypic variability suggests the possible role of still unknown factors influencing the effect of GFAP mutation and determining the phenotype.

  10. Alexander Tomov (1930-2009: A Founder of the Astronomical Photoelectric Photometry in Bulgaria [In Bulgarian

    Directory of Open Access Journals (Sweden)

    N. Tomov

    2011-08-01

    Full Text Available This paper describes the work of Dr. Alexander Tomov on establishment and equipment of the Astronomical Observatory of Belogradchik. Tomov’s research activity in that observatory is commented as well. The official opening of the observatory took place on July 21st, 1965. During the period 1966-1969 a monitoring program for determining the orbits of artificial satellites was successfully realized. Constructing a new building expanded later observatory. In mid-1969 the observatory was supplied by 60 cm reflector optical system ‘Cassegrain’, produced by Carl Zeiss in Germany; it was the biggest telescope in Bulgaria at that time. In the period 1970-1973 a modern single-channel photoelectric UBV photometer was constructed and put in operation. In 1976 the Belogradchik observatory joined with the Institute of Astronomy of the Bulgarian Academy of Sciences. In the second half of seventies and early eighties hundreds of galaxies were studied.

  11. Der Briefwechsel zwischen Karl Kreil und Alexander von Humboldt, ein wichtiger Beitrag zur Geschichte des Erdmagnetismus

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    Karin Reich

    2016-11-01

    Full Text Available Abstract The correspondence between Alexander von Humboldt und Karl Kreil was voluminous, it concerned earth magnetism. But only one letter has survived. This letter was written by Kreil on September 3, 1836; one day later Kreil wrote a letter to Carl Friedrich Gauss with nearly the same contents, some sentences are even literally corresponding. Four letters from Kreil to Humboldt were published in the „Annalen der Physik und Chemie“. Some letters were mentioned in the biographical literature dealing with Kreil. These letters show, that the correspondence covered at least the period until 1851 and give information about the intensive relationship between the two scientists. A further interesting source is the library of Humboldt which unfortunately has not survived. The catalogue mentions nine works of Kreil some of them where annotated by Humboldt. This makes it plausible that the contacts even lasted until 1856. Zusammenfassung Die Korrespondenz zwischen Alexander von Humboldt und Karl Kreil war umfangreich und betraf den Erdmagnetismus. Aber heute ist nur noch ein einziger Brief im Original bekannt. Dieser Brief, den Kreil am 3. September 1836 Alexander von Humboldt zukommen ließ, stimmt inhaltlich und teilweise wortwörtlich mit dem Brief überein, den Kreil nur einen Tag später, am 4. September 1836, an Carl Friedrich Gauß schickte. Vier Briefe von Kreil an Humboldt wurden in den „Annalen der Physik und Chemie“ publiziert, eine nicht allzu große Anzahl weiterer Briefe an Humboldt wurde in der biographischen Literatur über Kreil und in Briefen Kreils an Koller und Gauß erwähnt. Aber nicht nur die lückenhafte und bruchstückhaft bekannte Korrespondenz zwischen Humboldt und Kreil, die bis 1851 reicht, gibt Aufschluss über die Beziehungen, sondern von besonderer Bedeutung ist des Weiteren der Bestand an Kreiliana in der Bibliothek Humboldts. Es handelt sich um neun Werke Kreils, das letzte aus dem Jahr 1856. Nachweisbare

  12. Comparative-historical method in Slavic linguistics and Alexander Vostokov’s philological intuitions

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    Melkov Andrey Sergeevich

    2015-04-01

    Full Text Available The article is devoted to the estimation of Alexander Vostokov’s (1781-1864 contribution to the formation and development of the Slavic philology as a scientific discipline. In the foundation of the research there is the analyses of Vostokov’s work “Judgement about the Slavic language”, which has become the result of the scientist’s study the oldest Russian manuscript “Ostromir Gospels”. Vostokov devised a new method for the Slavic philology, which is used to call comparative-historical in modern science. The scientist gave the beginning of Old Church Slavonic and Old Russian written monuments scientific researching. Thanks to Vostokov’s discoveries, there has been formed the basis of Russian comparative-historical linguistics.

  13. Finding revelation in anthropology: Alexander Winchell, William Robertson Smith and the heretical imperative.

    Science.gov (United States)

    Livingstone, David N

    2015-09-01

    Anthropological inquiry has often been considered an agent of intellectual secularization. Not least is this so in the sphere of religion, where anthropological accounts have often been taken to represent the triumph of naturalism. This metanarrative, however, fails to recognize that naturalistic explanations could sometimes be espoused for religious purposes and in defence of confessional creeds. This essay examines two late nineteenth-century figures--Alexander Winchell in the United States and William Robertson Smith in Britain--who found in anthropological analysis resources to bolster rather than undermine faith. In both cases these individuals found themselves on the receiving end of ecclesiastical censure and were dismissed from their positions at church-governed institutions. But their motivation was to vindicate divine revelation, in Winchell's case from the physical anthropology of human origins and in Smith's from the cultural anthropology of Semitic ritual.

  14. Alexander Gordon, puerperal sepsis, and modern theories of infection control--Semmelweis in perspective.

    Science.gov (United States)

    Gould, Ian M

    2010-04-01

    Ignaz Semmelweis, a Hungarian doctor who practised in 19th century Vienna, is widely believed to be the father of modern infection control. He earned this accolade when he showed that puerperal sepsis was contagious and that it could be prevented with adequate hand hygiene. In fact, such ideas had circulated in the medical world for at least a century before Semmelweis' work. Moreover, it is well documented that Alexander Gordon, an obstetrician working in Aberdeen, UK, was the first to prove the contagious nature of puerperal sepsis. He also advocated the need for good hygiene for its prevention in a thesis published in 1795. This work described an epidemic of puerperal sepsis that began in Aberdeen in 1789. Gordon's thesis was reprinted three times in Edinburgh, Philadelphia, and London over the next 55 years, suggesting that Semmelweis (1847) could well have known of his work. Like Semmelweis, Gordon was persecuted for his findings. 2010 Elsevier Ltd. All rights reserved.

  15. Neuromusicology or Musiconeurology? "Omni-art" in Alexander Scriabin as a Fount of Ideas.

    Science.gov (United States)

    Triarhou, Lazaros C

    2016-01-01

    Science can uncover neural mechanisms by looking at the work of artists. The ingenuity of a titan of classical music, the Russian composer Alexander Scriabin (1872-1915), in combining all the sensory modalities into a polyphony of aesthetical experience, and his creation of a chord based on fourths rather than the conventional thirds are proposed as putative points of departure for insight, in future studies, into the neural processes that underlie the perception of beauty, individually or universally. Scriabin's "Omni-art" was a new synthesis of music, philosophy and religion, and a new aesthetic language, a unification of music, vision, olfaction, drama, poetry, dance, image, and conceptualization, all governed by logic, in the quest for the integrative action of the human mind toward a "higher reality" of which music is only a component.

  16. Neuromusicology or Musiconeurology? “Omni-art” in Alexander Scriabin as a Fount of Ideas

    Science.gov (United States)

    Triarhou, Lazaros C.

    2016-01-01

    Science can uncover neural mechanisms by looking at the work of artists. The ingenuity of a titan of classical music, the Russian composer Alexander Scriabin (1872–1915), in combining all the sensory modalities into a polyphony of aesthetical experience, and his creation of a chord based on fourths rather than the conventional thirds are proposed as putative points of departure for insight, in future studies, into the neural processes that underlie the perception of beauty, individually or universally. Scriabin’s “Omni-art” was a new synthesis of music, philosophy and religion, and a new aesthetic language, a unification of music, vision, olfaction, drama, poetry, dance, image, and conceptualization, all governed by logic, in the quest for the integrative action of the human mind toward a “higher reality” of which music is only a component. PMID:27014167

  17. Neuromusicology or musiconeurology? Omni-art in Alexander Scriabin as a fount of ideas

    Directory of Open Access Journals (Sweden)

    Lazaros C. Triarhou

    2016-03-01

    Full Text Available Science can uncover neural mechanisms by looking at the work of artists. The ingenuity of a titan of classical music, the Russian composer Alexander Scriabin (1872–1915, in combining all the sensory modalities into a polyphony of aesthetical experience, and his creation of a chord based on fourths rather than the conventional thirds are proposed as putative points of departure for insight, in future studies, into the neural processes that underlie the perception of beauty, individually or universally. Scriabin’s Omni-art was a new synthesis of music, philosophy and religion, and a new aesthetic language, a unification of music, vision, olfaction, drama, poetry, dance, image and conceptualization, all governed by logic, in the quest for the integrative action of the human mind toward a higher reality of which music is only a component.

  18. [Clinical and genetic study of twelve Chinese patients with Alexander disease].

    Science.gov (United States)

    Zang, Li-li; Wu, Ye; Wang, Jing-min; Gu, Qiang; Jiang, Yu-wu; Gao, Zhi-jie; Yang, Yan-ling; Xiao, Jiang-xi; Wu, Xi-ru

    2012-05-01

    To delineate the phenotype and genotype characteristics in 12 Chinese children with Alexander disease (AD), which is helpful for the molecular diagnosis and genetic counseling in China. Clinical diagnosis of AD was based on MRI criteria proposed by van der Knaarp in 2001. Included AD patients were followed up for 0.50 - 3.67 years. Mutations in GFAP were detected by DNA sequencing. The 12 cases of AD were clinically diagnosed. Age of first visit was 4.87 years (0.75 - 12.00 years), with 3 types of chief complaints: developmental delay in 3, recurrent seizures in 7, unable to walk after falling in 2. Average head circumference was 52.34 cm (44 - 58 cm), which larger than age-matched average by 6.45% (1.80% - 13.95%). On the first visit, scaling according to Gross motor functional classification system (GMFCS) was performed, with GMFCSI in 8, II in 3, V in 1. Mild to severe cognitive dysfunction were found in 8, and seizures in 11 cases. The 12 patients were followed up for 0.50 - 3.67 years, their motor and cognitive function remained stable. Episodic aggravations provoked by fever or falling were observed in 5 cases (41.67%). Heterozygous missense mutations of GFAP were detected in 12 patients. All mutations were de novo; 3 out of 10 mutations identified were novel. R79 and R239 were hot mutations, which was consistent with previous reports. Mutations were located in exon 1 in 8 cases. The phenotype in these patients is characterized by slower progression compared with reports from other population and high incidence of seizures. And episodic aggravations provoked by fever or falling were more common. The genotype characteristics are consistent with previous reports. The results of this research expanded the number of patients with Alexander disease found to have GFAP coding mutations in China.

  19. Screening for GFAP rearrangements in a cohort of Alexander disease and undetermined leukoencephalopathy patients.

    Science.gov (United States)

    Ferreira, Marie-Céleste; Dorboz, Imen; Rodriguez, Diana; Boespflug Tanguy, Odile

    2015-09-01

    Alexander disease (AxD), a fatal degenerative leukoencephalopathy, is caused by de novo heterozygous missense mutations in the Glial Fibrillary Acidic Protein (GFAP) gene. The pathological hallmark of the disease is the presence of Rosenthal fibers, cytoplasmic inclusions in astrocytes, composed mainly of GFAP, αB-crystallin and HSP27. To date, several patients with a typical presentation of the disease or displaying characteristic Rosenthal fibers in brain material have been reported with no GFAP mutation. Recently, several studies have demonstrated a correlation between Rosenthal fiber formation and wild-type GFAP overexpression, despite the absence of mutations. We tested the hypothesis that a GFAP gene rearrangement could modulate AxD severity or promote GFAP overexpression and aggregation, resulting in leukoencephalopathy. A QMPSF assay was validated for 11 exonic fragments: 3 in control genes (CFTR, DSCR1, F9) and 8 corresponding to GFAP exons. A total of 97 patients suspected of AxD were analyzed: 28 with a GFAP mutation; 69 with clinical and magnetic resonance imaging criteria compatible with the disease. Neither duplications nor deletions of GFAP were found, suggesting that GFAP coding-region rearrangements may not be involved in AxD or Alexander-related leukoencephalopathies. In addition, 80 patients with undetermined leukodystrophies, and negative for PLP1, GJA12, Sox10 and MCT8 mutations and PLP1 and Lamin B1 rearrangements, were tested. These patients were also negative for GFAP rearrangements. Other hypotheses should be investigated for a molecular diagnosis in patients with undetermined leukoencephalopathy: mutations in GFAP isoforms, splicing sites or regulatory regions, or defaults in genes encoding molecular partners of GFAP. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  20. Alexander Numan (1780-1852 en de veredeling van de Nederlandse schapenrassen

    Directory of Open Access Journals (Sweden)

    Jesper Oldenburger

    2015-10-01

    Full Text Available Alexander Numan and the improvement of the Dutch sheep breedsAlexander Numan’s life and work provide a splendid illustration of the early nineteenth-century Dutch scientist’s view of the role of science and scientists in society. As a professor at the Utrecht veterinary school he spent a substantial part of his time on a practical endeavour: the improvement of the wool quality of the Dutch sheep breeds. He did not confine his activities to the scientific aspects only, but aimed to obtain the active involvement of all relevant stakeholders in his project: the government, the sheep farmers and the wool industry.In the literature, Numan’s project is seen as a failure: the stakeholders were skeptical about his project from the beginning, as wool improvement was seen as a misguided aim. The Dutch wool industry was perfectly satisfied with the quality of the Dutch wool, and the trend among sheep breeders was to improve their sheeps’ meat meat quality rather than their wool. Eventually, the government withdrew its indispensable support.Nevertheless, Numan clung doggedly to the aim he had set himself, and the question we want to answer is this paper is why. We argue that the answer is to be found in Numan’s view of the role of science in society. His motives were not merely economic, but, first and foremost, of a moral nature. Wool quality, for him, was a measure of the level of civilization a country had reached. Social and cultural progress went hand in hand with the availability of higher quality clothing, the raw materials for which the Dutch sheep were as yet unable to provide. By providing these materials Numan was convinced to contribute directly to the well-being and cultural enhancement of the Dutch population, an objective that was characteristic of the self-fashioned private and public persona of the early nineteenth-century Dutch scientist.

  1. The Alexander Technique and musicians: a systematic review of controlled trials.

    Science.gov (United States)

    Klein, Sabine D; Bayard, Claudine; Wolf, Ursula

    2014-10-24

    Musculoskeletal disorders, stress and performance anxiety are common in musicians. Therefore, some use the Alexander Technique (AT), a psycho-physical method that helps to release unnecessary muscle tension and re-educates non-beneficial movement patterns through intentional inhibition of unwanted habitual behaviours. According to a recent review AT sessions may be effective for chronic back pain. This review aimed to evaluate the evidence for the effectiveness of AT sessions on musicians' performance, anxiety, respiratory function and posture. The following electronic databases were searched up to February 2014 for relevant publications: PUBMED, Google Scholar, CINAHL, EMBASE, AMED, PsycINFO and RILM. The search criteria were "Alexander Technique" AND "music*". References were searched, and experts and societies of AT or musicians' medicine contacted for further publications. 237 citations were assessed. 12 studies were included for further analysis, 5 of which were randomised controlled trials (RCTs), 5 controlled but not randomised (CTs), and 2 mixed methods studies. Main outcome measures in RCTs and CTs were music performance, respiratory function, performance anxiety, body use and posture. Music performance was judged by external experts and found to be improved by AT in 1 of 3 RCTs; in 1 RCT comparing neurofeedback (NF) to AT, only NF caused improvements. Respiratory function was investigated in 2 RCTs, but not improved by AT training. Performance anxiety was mostly assessed by questionnaires and decreased by AT in 2 of 2 RCTs and in 2 of 2 CTs. A variety of outcome measures has been used to investigate the effectiveness of AT sessions in musicians. Evidence from RCTs and CTs suggests that AT sessions may improve performance anxiety in musicians. Effects on music performance, respiratory function and posture yet remain inconclusive. Future trials with well-established study designs are warranted to further and more reliably explore the potential of AT in the

  2. Participating in and delivering the ATEAM trial (Alexander technique lessons, exercise, and massage) interventions for chronic back pain: A qualitative study of professional perspectives.

    Science.gov (United States)

    Beattie, Angela; Shaw, Alison; Yardley, Lucy; Little, Paul; Sharp, Debbie

    2010-01-01

    To outline professionals' experiences of participation, perceived benefits and acceptability of the interventions delivered in the ATEAM trial (Alexander technique lessons, exercise, and massage), for patients with chronic or recurrent back pain. Qualitative study using in-depth interviews was conducted with a purposeful sample of twenty professionals (general practitioners (GPs), nurses, Alexander technique teachers, and massage therapists). Data were recorded, transcribed, and analysed thematically using the constant comparison method. Evidence of effectiveness GPs wanted an evidence base for the interventions, whilst nurses, Alexander technique teachers and massage therapists perceived patient reports of benefit as evidence. Professionals' perception of the acceptability of the intervention: professional perspectives differed, with GPs and nurses viewing the structured nature of exercise prescription and Alexander technique lessons as more beneficial and acceptable than massage in alleviating patients' back pain. Economic cost: the cost to patients pursuing Alexander technique lessons and massage was perceived to be a barrier outside the trial. Inter-professional communication: there was little communication between the professionals groups within the trial. Valuable insights have been gained into the perceived benefits and acceptability of exercise, Alexander technique lessons and massage as interventions for chronic back pain. Lessons in the Alexander technique with or without exercise, was perceived as more beneficial and acceptable than massage by professionals who participated and delivered the ATEAM trial interventions. Copyright 2010 Elsevier Ltd. All rights reserved.

  3. “In the hour of trial”: the spiritual life and socio-political issues in sermons Archimandrite Alexander (Lovchiy

    Directory of Open Access Journals (Sweden)

    Murzin Evgenii

    2015-08-01

    Full Text Available The article is devoted to the study of the Orthodox segment of the religious and social thought in Germany during the Third Reich. The basis of the research were «Sunday flyers» — sermons compiled in the period of 1941–1945 by the prior of the st. Nicholas church in Munich, archimandrite Alexander (Lovchiy, one of the most prominent figures of Russian Orthodoxy. The article shows what the current issues the preacher cared about, demonstrates the specificity of his perception of the events. The author explores such themes as USSR and the Russian Orthodox Church, Christianity and national socialism, Russian emigration and its historic mission, science and religion, etc. Reflecting about the fate of Russia, Archimandrite Alexander appreciate happenings in the USSR as the punishment of God for anti-Church policy of the Bolsheviks. Нe compares Godless Soviet Russia and Russian Empire and dreams about its revival. He believes that the revival of the Empire is the duty of the Russian emigration. Simultaneously with the rejection of Communist ideology, Alexander criticizes and national-socialism and accuses its followers of trying to rehabilitate the paganism, hatred and cruelty. The preacher contrasts the ideas of racial superiority the gospel love, compassion and mercy, which constitute the moral basis of European civilization and guarantee its further development. He calls for the conviction of the authorities in cases when their actions are contrary to gospel principles. The article traces a parallel between denunciatory sermons rev. Alexander and leaflets, distributed in Bavaria by members of anti-fascist youth organization «White rose». Denunciatory sermons and leaflets have not only similar content. They also belong to the same period of time (The autumn of 1942. Based on the analysis of the content of leaflets and sermons, as well as specific historical circumstances, the autor suggestes that the relationship between

  4. Berglinien im Vergleich. Bemerkungen zu einem klimageografischen Diagramm Alexander von Humboldts

    Directory of Open Access Journals (Sweden)

    Birgit Schneider

    2013-04-01

    Full Text Available Zusammenfassung Der Artikel analysiert aus bildwissenschaftlicher und historischer Perspektive die unveröffentlichte Skizze zu einem Bergdiagramm aus dem handschriftlichen Nachlass Alexander von Humboldts. Das mehrfach beklebte Skizzenblatt stand im Zentrum klimageografischer Fragestellungen nach den Gründen für die weltweit unterschiedlich hohen Schneegrenzen in Gebirgen. Aufgrund des unfertigen, skizzenhaften Charakters des Diagramms lassen sich Fragen über den Forschungskontext des Diagramms, den epistemischen Stellenwert zeichnerischer Praktiken sowie über die heuristische Rolle der Berge und ihrer charakteristischen Profillinien in Humboldts Forschungen stellen. Gezeigt wird, wie das visuelle Denken und das Interesse Humboldts an neuen grafischen Methoden zu einer wichtigen Bedingung wurden, um die holistische Synopsis der Welt als ökologisches System erforschen und darstellen zu können. Abstract The article analyses from a visual studies and historical perspective the unpublished sketch of a mountain profile found among the handwritten papers of Alexander von Humboldt’s estate. The small sheet of sketches, with its pasted additions, was at the heart of climatic-geographic academic enquiry into the reasons for worldwide differences in the levels of mountain snow lines. The unfinished, sketchy nature of the diagramme raises questions about its research context, about the epistemic value of draughtsmanship practice and about the heuristic role of mountains and their characteristic profiles in Humboldt’s research. It becomes evident how Humboldt’s visual logic and his interest in new forms of graphics became important factors in investigation and depiction of the world as an ecological system. Resumen En el artículo se analizan los bocetos sin publicar de perspectivas históricas y de la ciencia de la imagen del diagrama montañoso de las obras póstumas escritas a mano de Alexander von Humboldt. La hoja de bocetos pegada de

  5. [Baltisches Welterlebnis. Die kulturgeschichtliche Bedeutung von Alexander, Eduard und Hermann Graf Keyserling. Beiträge eines internationalen Symposium in Tartu vom 19. bis 21. September 2003

    Index Scriptorium Estoniae

    Garleff, Michael, 1940-

    2011-01-01

    Baltisches Welterlebnis. Die kulturgeschichtliche Bedeutung von Alexander, Eduard und Hermann Graf Keyserling. Beiträge eines internationalen Symposium in Tartu vom 19. bis 21. September 2003. Heidelberg : Universitätsverlag Winter, 2007

  6. Exploring the psychological processes underlying touch: lessons from the Alexander Technique.

    Science.gov (United States)

    Jones, T; Glover, L

    2014-01-01

    The experience of touch is significant; both in its positive implications and in how it attracts caution and controversy. Accordingly, physical contact within psychological therapy has been shown to improve well-being and the therapeutic relationship, yet the majority of therapists never or rarely use touch. This research aimed to explore psychological processes underlying touch through the Alexander Technique, a psycho-physical technique taught one to one using touch. Six individuals who had received the Alexander Technique were interviewed, and 111 completed surveys. Interview data suggested an incompatibility between touch and the spoken word, which was understood through the way touch lacks verbal discourses in our society. The largely simplistic and dichotomous verbal understanding we have (either only very positive or very negative) could help understand some of the societal-level caution surrounding touch. Touch was seen also as a nurturing experience by interviewees, which influenced inter-personal and intra-personal relational processes. Developmental models were used to frame the way touch strengthened the pupil-teacher relationship and the way pupils' intra-personal psychological change seemed linked to this relational experience. The surveys largely supported these findings, and discussion is made around the notable way pupils negatively interpreted the intention of the survey. Implications for the use of touch in psychological therapies are discussed, as are limitations and ideas for future research. Touch is a powerful experience, and physical contact within psychological therapy has been shown to improve well-being and the therapeutic relationship, yet the majority of therapists never or rarely use touch. The AT is an alternative therapeutic approach to psycho-physical well-being that offers an interesting model to study the impact of touch. Findings from those that have used the technique reaffirmed that touch can improve well-being and can be a

  7. Unterwegs zum Weltbewußtsein. Alexander von Humboldts Wissenschaftsverständnis und die Entstehung einer ethisch fundierten Weltanschauung

    Directory of Open Access Journals (Sweden)

    Ottmar Ette

    2000-10-01

    Full Text Available Article in German, Abstracts in English and Spanish. Towards Global Consciousness. Alexander von Humboldt's Conception of Science and the emerging ethical Weltanschauung. In the context of recent reflections upon global ethics (Hans Küng, global democracy (Otfried Höffe and a new cultural situation after the end of the Cold War (Clifford Geertz, Alexander von Humboldt's concept of global consciousness (Weltbewußtsein marks a decisive point in the ungoing process of the construction of a new ethics of globalization. This article tries to show how Humboldt's transdisciplinary and intercultural conception of sience as WorldWideWeb integrates Kant's philosophical visions of global political institutions and formulates a critique of the non-empirical foundations of Hegel's teleological Weltanschauung. From his Visions of Nature and his Personal Narrative to his Cosmos, Humboldt's theory and practice of science help us to find a new ethos and new answers to the contemporary questions of divergent modernities.

  8. Kohti vapaampaa äänenkäyttöä : Alexander-tekniikka laulajan apuvälineenä

    OpenAIRE

    Kunnaala, Sini

    2017-01-01

    Tämä opinnäytetyö on kaksiosainen. A-osa käsittää opinnäytekonsertin Tyyni on ilta jääpuvussaan. Konsertti taltioitiin Maarian kirkossa 15.12.2016. B-osa opinnäytetyöstä on kirjallinen työ. Tämän opinnäytetyön tarkoitus on esittää Alexander-tekniikan ajatuksia laulajan apuvälineenä. Työssä esitellään sellaisia Alexander-tekniikan käsitteitä, jotka kirjoittaja on kokenut merkityksellisinä omassa oppimisprosessissaan. Työn soveltavassa osiossa kuvataan kirjoittajan omia oppimiskokemuksia Al...

  9. Rahne Alexander: Out in the Redwoods, Documenting Gay, Lesbian, Bisexual, Transgender History at the University of California, Santa Cruz, 1965-2003

    OpenAIRE

    Reti, Irene H.; Colliau, Erin

    2004-01-01

    Rahne Alexander was interviewed on February 11, 2002 and February 25, 2002 in Santa Cruz, California. Erin is a theorist and activist dedicated to transgender, feminist, anti-racist and anti-classist issues, and a personal friend of Rahne Alexander's. Rahne has been a student, activist, and workshop leader at UCSC and in Santa Cruz since the mid- to late-1990s. She is a tranny femme, MTF [Male to Female] activist.

  10. Knowledge about Students in the USA: 30 Years of Educational Research. An Interview with Alexander W. Astin

    Directory of Open Access Journals (Sweden)

    Eliézer de los Santos Valadez

    2001-05-01

    Full Text Available In this interview, Doctor Alexander Astin retraces the work he has done in the last 30 years. He explains about the relevance of getting to know higher education students, since being acquainted with their school trajectory inside and outside campus, is fundamental to institutional decision-making. Doctor Astin also states the importance of evaluating an institution's quality by investigating the students' learning.

  11. Jade aus Amerika und weitere Grünsteinobjekte von Alexander von Humboldt aus dem Berliner Mineralienkabinett

    OpenAIRE

    Renate Nöller

    2009-01-01

    Alexander von Humboldt schickte aus Amerika Mineralproben, die nicht nur von naturwissenschaftlichem oder wirtschaftlichem Interesse waren. Vor allem grünes Steinmaterial, sogenannte Jade, war in Mesoamerika kulturell sehr bedeutsam und weit verbreitet, so daß sich aus diesem Rohstoff in der Sammlung auch bearbeitete Stücke vorfinden. Sie erlangten in Europa unterschiedliche Aufmerksamkeit. Die Jadeaxt und die Sonnenscheibe - beide im zweiten Weltkrieg verloren gegangen, hatten als “Humboldt-...

  12. Future population trends and drivers of change for Alexander Archipelago wolves on and near Prince of Wales Island, Alaska

    OpenAIRE

    Gilbert, Sophie L.; Haynes, Trevor; Lindberg, Mark S.; Albert, David; Kissling, Michelle; David K. Person

    2016-01-01

    Background. The Alexander Archipelago wolf, inhabiting the coastal temperate rainforest of North America, was recently evaluated for protection under the U.S. Endangered Species Act, but ultimately was not listed. Stressors thought to be impacting the population include about habitat alteration from industrial timber harvest and subsequent declines in prey (deer), increased human-caused mortality, and climate change. Methods. To evaluate how these factors likely will affect future abundance o...

  13. [Is the psyche antiquated? A typology of psychotherapeutic critique of civilization in the works of Alexander Mitscherlich].

    Science.gov (United States)

    Roelcke, V

    1995-08-01

    In the oeuvre of the psychotherapist Alexander Mitscherlich, one of the founding-fathers of psychosomatic medicine in post-war Germany, three basic types of critique of civilization can be identified. They each imply a specific conception of the relation between modernity and psychological disorder. Mitscherlich's ideas on the topic have evolved in a manner consistent with his appropriation of psychoanalysis and his confrontation with the causes and consequences of human behaviour during the time of national socialism.

  14. In memoriam: Alexander Ivanovskii, innovative researcher and science manager in computational materials science of advanced inorganic materials

    OpenAIRE

    BANNIKOV V.V.; DENISOVA T.A.; ENYASHIN A.N.; MEDVEDEVA N.I.; SHEIN I.R.; SUETIN D.V.; ZHUKOV V.P.; KUZNETSOV M.V.

    2014-01-01

    The paper is written to pay a tribute to Prof. Alexander Leonidovich Ivanovskii, Head of the Quantum Chemistry and Spectroscopy Laboratory at the Institute of Solid State Chemistry, Ural Branch of the Russian Academy of Sciences (RAS), and is devoted to recalling the most signi cant landmarks in his scienti c career. A broad-minded man of great erudition, A. L. Ivanovskii made invaluable contributions in the eld of computational materials science | a new eld of research covering computational...

  15. GFAP mutations, age at onset, and clinical subtypes in Alexander disease.

    Science.gov (United States)

    Prust, M; Wang, J; Morizono, H; Messing, A; Brenner, M; Gordon, E; Hartka, T; Sokohl, A; Schiffmann, R; Gordish-Dressman, H; Albin, R; Amartino, H; Brockman, K; Dinopoulos, A; Dotti, M T; Fain, D; Fernandez, R; Ferreira, J; Fleming, J; Gill, D; Griebel, M; Heilstedt, H; Kaplan, P; Lewis, D; Nakagawa, M; Pedersen, R; Reddy, A; Sawaishi, Y; Schneider, M; Sherr, E; Takiyama, Y; Wakabayashi, K; Gorospe, J R; Vanderver, A

    2011-09-27

    To characterize Alexander disease (AxD) phenotypes and determine correlations with age at onset (AAO) and genetic mutation. AxD is an astrogliopathy usually characterized on MRI by leukodystrophy and caused by glial fibrillary acidic protein (GFAP) mutations. We present 30 new cases of AxD and reviewed 185 previously reported cases. We conducted Wilcoxon rank sum tests to identify variables scaling with AAO, survival analysis to identify predictors of mortality, and χ(2) tests to assess the effects of common GFAP mutations. Finally, we performed latent class analysis (LCA) to statistically define AxD subtypes. LCA identified 2 classes of AxD. Type I is characterized by early onset, seizures, macrocephaly, motor delay, encephalopathy, failure to thrive, paroxysmal deterioration, and typical MRI features. Type II is characterized by later onset, autonomic dysfunction, ocular movement abnormalities, bulbar symptoms, and atypical MRI features. Survival analysis predicted a nearly 2-fold increase in mortality among patients with type I AxD relative to those with type II. R79 and R239 GFAP mutations were most common (16.6% and 20.3% of all cases, respectively). These common mutations predicted distinct clinical outcomes, with R239 predicting the most aggressive course. AAO and the GFAP mutation site are important clinical predictors in AxD, with clear correlations to defined patterns of phenotypic expression. We propose revised AxD subtypes, type I and type II, based on analysis of statistically defined patient groups.

  16. Speciation despite globally overlapping distributions in Penicillium chrysogenum: the population genetics of Alexander Fleming's lucky fungus.

    Science.gov (United States)

    Henk, D A; Eagle, C E; Brown, K; Van Den Berg, M A; Dyer, P S; Peterson, S W; Fisher, M C

    2011-10-01

    Eighty years ago, Alexander Fleming described the antibiotic effects of a fungus that had contaminated his bacterial culture, kick starting the antimicrobial revolution. The fungus was later ascribed to a putatively globally distributed asexual species, Penicillium chrysogenum. Recently, the species has been shown to be genetically diverse, and possess mating-type genes. Here, phylogenetic and population genetic analyses show that this apparently ubiquitous fungus is actually composed of at least two genetically distinct species with only slight differences detected in physiology. We found each species in air and dust samples collected in and around St Mary's Hospital where Fleming worked. Genotyping of 30 markers across the genome showed that preserved fungal material from Fleming's laboratory was nearly identical to derived strains currently in culture collections and in the same distinct species as a wild progenitor strain of current penicillin producing industrial strains rather than the type species P. chrysogenum. Global samples of the two most common species were found to possess mating-type genes in a near 1:1 ratio, and show evidence of recombination with little geographic population subdivision evident. However, no hybridization was detected between the species despite an estimated time of divergence of less than 1MYA. Growth studies showed significant interspecific inhibition by P. chrysogenum of the other common species, suggesting that competition may facilitate species maintenance despite globally overlapping distributions. Results highlight under-recognized diversity even among the best-known fungal groups and the potential for speciation despite overlapping distribution. © 2011 Blackwell Publishing Ltd.

  17. Quantitative Evaluation of Brain Stem Atrophy Using Magnetic Resonance Imaging in Adult Patients with Alexander Disease.

    Science.gov (United States)

    Yoshida, Tomokatsu; Yasuda, Rei; Mizuta, Ikuko; Nakagawa, Masanori; Mizuno, Toshiki

    2017-01-01

    Brain MRI in adult patients with Alexander disease (AxD) mainly shows atrophy in the medulla oblongata. However, currently there is no quantitative standard for assessing this atrophy. In this study, we quantitatively evaluated the brain stem of AxD patients with glial fibrillary acidic protein (GFAP) mutation using conventional MRI to evaluate its usefulness as an aid to diagnosing AxD in daily clinical practice. Nineteen AxD patients with GFAP mutation were compared with 14 patients negative for GFAP mutation in whom AxD was suspected due to "atrophy of the medulla oblongata." In the GFAP mutation-positive group, the sagittal diameter of the medulla oblongata, the ratio of the diameter of the medulla oblongata to that of the midbrain (MO/MB), and the ratio of the sagittal diameter of the medulla oblongata to that of the pons (MO/Po) were significantly smaller compared to those of the GFAP mutation-negative group (p < 0.01). The sensitivity and specificity of each parameter were 87.5 and 92.3%, 91.7 and 81.3%, and 88.2 and 100% with a sagittal diameter of the medulla oblongata <9.0 mm, MO/MB <0.60, and sagittal MO/Po <0.46, respectively. These parameters can provide very useful information to differentially diagnose AxD from other disorders associated with brain stem atrophy in adult patients. © 2017 S. Karger AG, Basel.

  18. Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease.

    Science.gov (United States)

    Heaven, Michael R; Flint, Daniel; Randall, Shan M; Sosunov, Alexander A; Wilson, Landon; Barnes, Stephen; Goldman, James E; Muddiman, David C; Brenner, Michael

    2016-07-01

    Alexander disease (AxD) is a neurodegenerative disorder characterized by astrocytic protein aggregates called Rosenthal fibers (RFs). We used mouse models of AxD to determine the protein composition of RFs to obtain information about disease mechanisms including the hypothesis that sequestration of proteins in RFs contributes to disease. A method was developed for RF enrichment, and analysis of the resulting fraction using isobaric tags for relative and absolute quantitation mass spectrometry identified 77 proteins not previously associated with RFs. Three of five proteins selected for follow-up were confirmed enriched in the RF fraction by immunobloting of both the AxD mouse models and human patients: receptor for activated protein C kinase 1 (RACK1), G1/S-specific cyclin D2, and ATP-dependent RNA helicase DDX3X. Immunohistochemistry validated cyclin D2 as a new RF component, but results for RACK1 and DDX3X were equivocal. None of these was decreased in the non-RF fractions compared to controls. A similar result was obtained for the previously known RF component, alphaB-crystallin, which had been a candidate for sequestration. Thus, no support was obtained for the sequestration hypothesis for AxD. Providing possible insight into disease progression, the association of several of the RF proteins with stress granules suggests a role for stress granules in the origin of RFs.

  19. Atypical MRI features in familial adult onset Alexander disease: case report.

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    Liu, Yonghong; Zhou, Heng; Wang, Huabing; Gong, Xiaoqing; Zhou, Anna; Zhao, Lin; Li, Xindi; Zhang, Xinghu

    2016-11-04

    Alexander disease (AxD) is a rare neurological disease, especially in adults. It shows variable clinical and radiological features. We diagnosed a female with AxD presenting with paroxysmal numbness of the limbs at the onset age of 28-year-old, progressing gradually to spastic paraparesis at age 30. One year later, she had ataxia, bulbar paralysis, bowel and bladder urgency. Her mother had a similar neurological symptoms and died within 2 years after onset (at the age of 47), and her maternal aunt also had similar but mild symptoms at the onset age of 54-year-old. Her brain magnetic resonance imaging (MRI) showed abnormal signals in periventricular white matter with severe atrophy in the medulla oblongata and thoracic spinal cord, and mild atrophy in cervical spinal cord, which is unusual in the adult form of AxD. She and her daughter's glial fibrillary acidic protein (GFAP) gene analysis revealed the same heterozygous missense mutation, c.1246C > T, p.R416W, despite of no neurological symptoms in her daughter. Our case report enriches the understanding of the familial adult AxD. Genetic analysis is necessary when patients have the above mentioned symptoms and signs, MRI findings, especially with family history.

  20. GFAP expression as an indicator of disease severity in mouse models of Alexander disease.

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    Jany, Paige L; Hagemann, Tracy L; Messing, Albee

    2013-01-01

    AxD (Alexander disease) is a rare disorder caused by heterozygous mutations in GFAP (glial fibrillary acidic protein) resulting in accumulation of the GFAP protein and elevation of Gfap mRNA. To test whether GFAP itself can serve as a biomarker of disease status or progression, we investigated two independent measures of GFAP expression in AxD mouse models, one using a genetic reporter of promoter activity and the other quantifying GFAP protein directly in a manner that could also be employed in human studies. Using a transgenic reporter line that expresses firefly luciferase under the control of the murine Gfap promoter (Gfap-luc), we found that luciferase activity reflected the regional CNS (central nervous system) variability of Gfap mRNA in Gfap(+/+) mice, and increased in mice containing a point mutation in Gfap that mimics a common human mutation in AxD (R239H in the human sequence, and R236H in the murine sequence). In a second set of studies, we quantified GFAP protein in CSF (cerebrospinal fluid) taken from three different AxD mouse models and littermate controls. GFAP levels in CSF were increased in all three AxD models, in a manner corresponding to the concentrations of GFAP in brain. These studies demonstrate that transactivation of the Gfap promoter is an early and sustained indicator of the disease process in the mouse. Furthermore, GFAP in CSF serves as a potential biomarker that is comparable between mouse models and human patients.

  1. Synemin is expressed in reactive astrocytes and Rosenthal fibers in Alexander disease.

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    Pekny, Tulen; Faiz, Maryam; Wilhelmsson, Ulrika; Curtis, Maurice A; Matej, Radoslav; Skalli, Omar; Pekny, Milos

    2014-01-01

    Alexander disease (AxD) is a neurodegenerative disorder with prominent white matter degeneration and the presence of Rosenthal fibers containing aggregates of glial fibrillary acidic protein (GFAP), and small stress proteins HSP27 and αB-crystallin, and widespread reactive gliosis. AxD is caused by mutations in GFAP, the main astrocyte intermediate filament protein. We previously showed that intermediate filament protein synemin is upregulated in reactive astrocytes after neurotrauma. Here, we examined immunohistochemically the presence of synemin in reactive astrocytes and Rosenthal fibers in two patients with AxD. There was an abundance of GFAP-positive Rosenthal fibers and widespread reactive gliosis in the white matter and subpial regions. Many of the GFAP-positive reactive astrocytes were positive for synemin, and synemin was also present in Rosenthal fibers. We show that synemin is expressed in reactive astrocytes in AxD, and is also present in Rosenthal fibers. The potential role of synemin in AxD pathogenesis remains to be investigated. © 2013 APMIS Published by Blackwell Publishing Ltd.

  2. A Multilingual Monologue: Alexander Lenard’s Self-Translated Autobiography in Three Languages

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    Helga Lénárt-Cheng

    2015-01-01

    Full Text Available The paper investigates the question of self-translation in the work of Alexander Lenard (Lénárd Sándor. Lenard, a polyglot writer and translator, rewrote his autobiography three times, in three different languages (in German, English, and Hungarian. This process of self-translation created a fascinating web of autobiographical texts, which invite a multiscopic reading. Following in the footsteps of 18th century parodists, Lenard challenges a great number of protocols associated with life-writing. The most important among these is the authority of the proper name as a guarantee of autobiographical authenticity. To challenge the authority of the proper name Lenard purposely multiplies his own authorial identities, for example by claiming that “A. L. is only a pseudonym.” Thus, the word ‘self-plagiarism’ acquires in Lenard’s case a double meaning, implying both that the author plagiarizes his own text and that he plagiarizes his own self. The paper explains why existing theories of self-translation cannot be applied to Lenard’s texts, and why his unique case can enrich future studies of this topic.

  3. Zum Verhältnis Charles Darwins zu Alexander v. Humboldt und Christian Gottfried Ehrenberg

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    Petra Werner

    2009-05-01

    Full Text Available Article in German, Abstracts in English and German.While it is well known that Charles Darwin and Alexander von Humboldt appreciated each other's work, Humboldt's influence on Darwin has not yet been thoroughly examined. The following paper shows to what extent Darwin was inspired by Humboldt's publications while writing his Origin of Species.Darwin paid special attention to Humboldt's observations on plant migration and throughout his whole scientific career he used Humboldt's books as a major source of information. In fact, Darwin's last annotations in his copy of the Personal Narrative of travels to the Equinoctial Regions of the New continent during the Years 1799-1804 date back to the last weeks of his life.On the other hand, Darwin rejected many of Humboldt's scientific conclusions. The two authors differed in their assessment of Heinrich Bronn's biological research. Finally, Darwin was dissatisfied with Humboldtís last work Cosmos because it did not contain the information he expected. Darwinís collaboration with Humboldt's travel companion Christian Gottfried Ehrenberg proved to be similarly disappointing. Darwin sent 183 samples of infusoria to Berlin, but the results of Ehrenberg's analysis did not support Darwin's theory on evolution.

  4. A Niche for Subjectivity: Emergence and Process according to S. Alexander and A. N. Whitehead

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    Maria Regina Brioschi

    2013-11-01

    Full Text Available Perché un articolo sulla soggettività emergente? Se da una parte l’emergentismo offre un nuovo paradigma per pensare la soggettività oltre ogni dualismo, dall’altra il tema della soggettività mette in questione lo stesso emergentismo. Così, in generale, il presente articolo si interroga su cosa sia una soggettività emergente, e come si costituisca, procedendo in questa interrogazione mediante il pensiero di Samuel Alexander e Alfred North Whitehead. Il primo infatti presenta un coerente sistema emergentista, in cui la soggettività trova il suo posto, pur rimanendo ancorato ad un’interpretazione classica di soggettività, concepita come mente. Il secondo invece offre un modello più innovativo di soggettività, che implica una revisione radicale della sua temporalità e «mondanità», e che lo porta in ultima analisi al di là di una posizione emergentista in senso stretto.

  5. Writing in learning/teaching in French (study case- freshmen “Alexander Xhuvani” University students

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    Leonarda Myslihaka

    2017-03-01

    Full Text Available Writing plays an important role in teaching and learning foreign languages. Students that can write in a foreign language have to verify their grammar, lexical and semantic performance and it is the role of the teacher to assess if students have learned rules correctly. This is both important for their reading and speaking skills and in general students are tested through a writing test. Writing is now an object of research and it is generally accepted that teaching/ learning cannot be performed out of the communicative acts. Students are required to produce and interpret different documents such as leaflets, journal articles etc. in a foreign language, in this case in French. The idea is that if you want to own the writing competency, you have to know very well both the lingual and contextual structure. This paper is a based on a research conducted with the first year students, studying French at the “Alexander Xhuvani” University, Elbasan, Albania, taking in consideration the lingual, psychological and social factors that affect writing. From the conclusions was clear that students had difficulties in writing due to their limited lingual competencies that leads them to orthographical mistakes etc. We also noted that students are eager to acquire this competency because learning a language through writing does not merely mean to learn syntax but it also requires a de – contextualization and creating a chance for students to get in touch with everyday language texts.

  6. Alexander Scriabin: his chronic right-hand pain and Its impact on his piano compositions.

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    Altenmüller, Eckart

    2015-01-01

    Alexander Scriabin was an outstanding pianist and an avant-garde composer who influenced later generations with his innovative "multimedia" conceptions of aesthetic experience. As an adolescent, he was systematically trained as a concert pianist and received lessons from Vassily Safonoff, one of the founders of the legendary Russian Piano School. At age 20, Scriabin suffered an overuse injury of his right hand when attempting to improve the sound quality of his piano touch. This injury caused a deep crisis and influenced his later composition style in his piano works. From this time on, his works were frequently dominated by unusual virtuosic use and wide spans of his left hand. Rest, restricted repertoire, and an increased focus on composition contributed to recovery; however, he always remained anxious concerning the stamina of his right hand. The case report impressively demonstrates the stressors an aspiring young pianist had to cope with at the end of the nineteenth century. Furthermore, it is a convincing example of how resource-oriented behavior and intuition lead to the improvement of health status. Differential diagnoses and the modern concept of multimodal pain therapy in chronic overuse injury will be discussed from a historical perspective. © 2015 Elsevier B.V. All rights reserved.

  7. The Development of Information Policy of the Russian Empire During the Reign of Alexander II

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    Elena S. Ustinovich

    2015-03-01

    Full Text Available During this historical period was actively carried out the process of interaction and interdependence of the development of state power and social consciousness within the limits of formation of the state information policy. Alexander II and his inner circle, given these trends and evaluating the shortcomings of the reign of his father, after years of ignoring the power of public opinion on important socio-political and socio-economic issues, after a long ban on open discussion of the shortcomings of the actions of the authorities and of the state apparatus, deliberately stimulated the beginning of the «era of conviction». Growth of social consciousness, the press has naturally gained a strong influence on representatives of the Russian society and contributed to raising awareness of and advocate for their rights. The authority is committed to the advancement of social development, directs itself to the expansion of media freedom and on the settlement of socio-political issues through dialogue, carried out with the assistance of the media.

  8. The Russian secret service and King Alexander Obrenović of Serbia (1900-1903

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    Rajić Suzana

    2012-01-01

    Full Text Available The period of 1900-1903 saw three phases of cooperation between the Rus­sian Secret Service (Okhrana and King Alexander Obrenović of Serbia. It is safe to say that the Secret Service operated in Serbia as an extended arm of the Russian Ministry of Foreign Affairs, i.e. of its diplomatic mission in Belgrade. Its goal was to fortify the position of Russia in Serbia after King Alexander’s wedding and the departure of his father, ex-King Milan (who abdicated in 1889 in favour of his minor son, from the country. The Serbian King, however, benefited little from the cooperation, because he did not receive assistance from the Secret Service when he needed it most. Thus, the issue of conspiracy against his life was lightly treated throughout 1902 until his assassination in 1903. In the third and last period of cooperation, from the beginning of 1902 until the King’s assassination on 11 June 1903,1 the Russian ministries of Internal and Foreign Affairs forbade the agents to receive money from the Serbian King and relieved them of any duty regarding the protection of his life. [Projekat Ministarstva nauke Republike Srbije, br. 177014: Serbian nation: Integrating and disintegrating processes

  9. Alexander von Humboldt's Idea of Interconnectedness and its Relationship to Interdisciplinarity and Communication

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    Detlev Doherr

    2015-10-01

    Full Text Available Alexander von Humboldt, a German scientist and explorer of the 19th century, viewed the natural world holistically and described the harmony of nature among the diversity of the physical world as a conjoining between all physical disciplines. He noted in his diary: "Everything is interconnectedness." The main feature of Humboldt's pioneering work was later named "Humboldtian science", meaning the accurate study of interconnected real phenomena in order to find a definite law and a dynamic cause. Following Humboldt's idea of nature, an Internet edition of his works must preserve the author's original intention, retain an awareness of all relevant works, and still adhere to the requirements of scholarly edition. At the present time, however, the highly unconventional form of his publications has undermined the awareness and a comprehensive study of Humboldt's works. Digital libraries should supply dynamic links to sources, maps, images, graphs and relevant texts. New forms of interaction and synthesis between humanistic texts and scientific observation need to be created. Information technology is the only way to do justice to the broad range of visions, descriptions and the idea of nature of Humboldt's legacy. It finally leads to virtual research environments as an adequate concept to redesign our digital archives, not only for Humboldt's documents, but for all interconnected data.

  10. Rediscovering MDMA (ecstasy): the role of the American chemist Alexander T. Shulgin.

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    Benzenhöfer, Udo; Passie, Torsten

    2010-08-01

    Alexander T. Shulgin is widely thought of as the 'father' of +/-3,4-methylenedioxymethamphetamine (MDMA). This paper re-assesses his role in the modern history of this drug. We analysed systematically Shulgin's original publications on MDMA, his publications on the history of MDMA and his laboratory notebook. According to Shulgin's book PIHKAL (1991), he synthesized MDMA in 1965, but did not try it. In the 1960s Shulgin also synthesized MDMA-related compounds such as 3,4-methylenedioxyamphetamine (MDA), 3-methoxy-4,5-methylenedioxyamphetamine (MMDA) and 3,4-methylenedioxyethylamphetamine (MDE), but this had no impact on his rediscovery of MDMA. In the mid-1970s Shulgin learned of a 'special effect' caused by MDMA, whereupon he re-synthesized it and tried it himself in September 1976, as confirmed by his laboratory notebook. In 1977 he gave MDMA to Leo Zeff PhD, who used it as an adjunct to psychotherapy and introduced it to other psychotherapists. Shulgin was not the first to synthesize MDMA, but he played an important role in its history. It seems plausible that he was so impressed by its effects that he introduced it to psychotherapist Zeff in 1977. This, and the fact that in 1978 he published with David Nichols the first paper on the pharmacological action of MDMA in humans, explains why Shulgin is sometimes (erroneously) called the 'father' of MDMA.

  11. La fabrique du savoir Essai sur les carnets de voyage d'Alexander von Humboldt

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    Marie-Noëlle Bourguet

    2006-10-01

    Full Text Available Article in French, Abstract in English.Whilst the notebook belongs to the imagery of the enlightened scientist's persona (an auxiliary tool kept by his side to be hastily scribbled with data, when at the bench or in the field, it has been given little attention by historians of science, who are used to consider its manuscript pages as a documentary resource to complement the printed text, but rarely take the notebook as a material and cultural object by itself, the history and epistemology of which is to be explored. Only recently have new trends in the historiography, by historians of printed books and reading practices, and by social and cultural historians of knowledge, called for a fresh look and opened the way for new approaches. Taking Alexander von Humboldt as a paramount example, who expressly devoted his life to "observing and recording" the world, pen in hand, this paper explores the note-taking practices at work in his travel diaries and notebooks from the perspective of the history of scientific observation and cognitive practices. Four themes are successively considered : the question of method and apprenticeship ; the timing of note-taking practices ; the nature and status of the data jotted down on the page ; finally, their uses in the production of scientific knowledge. In the back and forth movement between the observation of the world and the writing of science, the notebook stood as a crucial intellectual step and cognitive tool.

  12. Causes of ransom private railways in the Russian Empire during the reign of Alexander III

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    Pavel A. Gurianov

    2016-03-01

    Full Text Available This article focuses on a number of reasons, redemption of private railways in the Russian Empire during the reign of Alexander III. Preconditions for this step. After the defeat in the Crimean War, the state began to consider two basic ways construction of railways: the expense of the treasury at the expense of private capital, including foreign ones. Attempts to organize joint capital of private foreign and domestic on the example of the main Russian Railway Company ended sadly. Foreign capital is mainly interested in speculation on the Russian stock exchange, as a result the majority of the company's shares went to the Russian capital. To support the private Russian capital the government has gone the way of the guarantee capital, in certain cases, as a joint stock or bond or one of the types of capital. When distribution concessions were not crucial economic factors, and the proximity to the elite or the corruption component. Often concession won by those who offered the lowest price, which affects the quality of railway construction in the country. As a result of the concession is not got the most professionally trained people who are almost entirely the burden shifted to the state, and profits for the most part getting any private owners. As a result, such practice is ruinous for the Treasury forced the government to buy back a significant portion of private railways on acceptable terms. As a result, initially malpractice and corruption safeguards prevent a real manifestation of self-employment initiatives

  13. Professor Alexander Zawadzki of Lvov university – Gregor Mendel’s mentor and inspirer

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    Szybalski W.

    2010-04-01

    Full Text Available It is generally agreed that Johann Gregor Mendel (1822–1884 is the undisputed father of genetics, the study of heredity that is fundamental to our understanding of all living things. However, as a geneticist and engineer, strongly influenced by my teachers in Lvov and Gdansk, in Copenhagen and in Cold Spring Harbor (NY, I have always wondered how it was possible for Mendel to be such an independent thinker while not having a mentor who could have guided his creative and analytical thinking. Was there anybody in Mendel’s life who could have played this role? At the very least, did he get any opportunity to discuss his experimental designs with some colleague or to receive any help from a mentor or a friend in analyzing his results? The purpose in preparing this essay is to bring to light a long neglected story of how an «obscure Polish Professor from Lvov University», Alexander Zawadzki, played a critical role in helping an «obscure Austrian monk», Gregor Mendel, to create the discipline of genetics.

  14. Older adult Alexander Technique practitioners walk differently than healthy age-matched controls.

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    Hamel, Kate A; Ross, Christopher; Schultz, Brooke; O'Neill, Matthew; Anderson, David I

    2016-10-01

    The Alexander Technique (AT) seeks to eliminate harmful patterns of tension that interfere with the control of posture and movement and in doing so, it may serve as a viable intervention method for increasing gait efficacy in older adults. The purpose of this study was to compare the comfortable pace gait kinematics of older AT practitioners with those of healthy, age-matched controls. Participants were six licensed AT practitioners and seven healthy age-matched controls between the ages of 61-76. During the stance phase, AT participants exhibited significantly greater ankle stance range of motion (ROM) and plantar flexion at toe off, as well as lower ROM of the trunk and head compared to controls. During the swing phase, the AT practitioners had significantly increased hip and knee flexion and a trend toward significantly increased dorsiflexion. The findings suggest that the older AT practitioners walked with gait patterns more similar to those found in the literature for younger adults. These promising results highlight the need for further research to assess the AT's potential role as an intervention method for ameliorating the deleterious changes in gait that occur with aging. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. PRAYER AND THE "SPIRITUAL CONSTITUENT" IN THE IMAGE OF A BELOVED IN ALEXANDER PUSHKIN'S LYRIC POETRY

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    Elena Alexandrovna Kuchina

    2013-11-01

    Full Text Available Prayer in Alexander Pushkin's lyric poetry appears in its natural ecclesiological context. In his prayerful poems devoted to a woman the motif of turning Love into Divinity in the light of Christian understanding of Beauty plays the most important role. Pushkin's personal prayers are very close to the patristic idea. In his poem Akathist to Ekaterina Nikolaevna Karamzina Pushkin embodied the prayer-praising; in his poem I loved you — and love it may yet be Deep in my soul... he embodied the prayer-blessing; in his sonnet Madonna the reader can find benediction and in the poem To the Beauty (1832 one can feel the state of religious reverence. The heroine of these poems is considered to be a divine creature, a sacral image. In Pushkin's lyric poetry these profound evangelical ideas are renewed. The hymnologic genre and Christian divine service in his poems become obvious. The artistic embodiment of a prayer becomes possible with the help of an iconic word and image. A prayerful word in Pushkin's poems contributes to idealization of the form that evolves from emotional and sensual state to spiritual and ascetical world-view, from the artistic and figurative word to the iconic clarity.

  16. What is the perceived impact of Alexander technique lessons on health status, costs and pain management in the real life setting of an English hospital? The results of a mixed methods evaluation of an Alexander technique service for those with chronic back pain.

    Science.gov (United States)

    McClean, Stuart; Brilleman, Sam; Wye, Lesley

    2015-07-28

    Randomised controlled trial evidence indicates that Alexander Technique is clinically and cost effective for chronic back pain. The aim of this mixed methods evaluation was to explore the role and perceived impact of Alexander Technique lessons in the naturalistic setting of an acute hospital Pain Management Clinic in England. To capture changes in health status and resource use amongst service users, 43 service users were administered three widely used questionnaires (Brief Pain Inventory, MYMOP and Client Service Resource Inventory) at three time points: baseline, six weeks and three months after baseline. We also carried out 27 telephone interviews with service users and seven face-to-face interviews with pain clinic staff and Alexander Technique teachers. Quantitative data were analysed using descriptive statistics and qualitative data were analysed thematically. Those taking Alexander Technique lessons reported small improvements in health outcomes, and condition-related costs fell. However, due to the non-randomised, uncontrolled nature of the study design, changes cannot be attributed to the Alexander Technique lessons. Service users stated that their relationship to pain and pain management had changed, especially those who were more committed to practising the techniques regularly. These changes may explain the reported reduction in pain-related service use and the corresponding lower associated costs. Alexander Technique lessons may be used as another approach to pain management. The findings suggests that Alexander Technique lessons can help improve self-efficacy for those who are sufficiently motivated, which in turn may have an impact on service utilisation levels.

  17. Alexander von Humboldt: Wissenschaft im Feld Transareale Wissenschaftsfelder in den Tropen

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    Ottmar Ette

    2011-10-01

    Full Text Available ZusammenfassungAlexander von Humboldt verstand sich zwar sicher nicht als Direktor eines Museums, war aber sehr wohl der Welt der Museen, Bibliotheken und Archive nicht nur als Besucher und Leser, sondern auch als Sammler und Forscher verpflichtet. Durch seine Forschungsreisen nach Amerika und Asien vermehrte er im Verlauf eines langen Gelehrtenlebens viele Sammlungen durch eigene Sammeltätigkeit vor Ort. Seine Feldforschung blieb dabei nicht auf naturwissenschaftliche Aspekte begrenzt, sondern bezog ganz selbstverständlich auch die verschiedenartigsten kulturwissenschaftlichen Forschungsgegenstände mitein. Diese transdisziplinär agierende Praxis im Feld lässt sich zugleich als eine transareale, einzelne Areas übergreifende und damit im Sinne von TransArea Studies aus den Beziehungen, Zirkulationen und Wechselwirkungen jenseits des bloß Territorialen sich speisende Wissenschaftskonzeption begreifen. So lässt sich in seiner Auseinandersetzung mit der amerikanischen Tropenwelt eine doppelte transareale Relationalität erkennen, die einerseits intern die Tropenwelt unterschiedlicher Kontinente miteinander verbindet, andererseits aber extern die Tropen insbesondere mit den gemäßigten Zonen in Relation setzt, um dadurch erst globale Zusammenhänge - einschließlich der sich verändernden Schneegrenzen oder der Wanderungsbewegungen der Pflanzenformen, für die sich die mobile Wissenschaft Humboldts in besonderem Maße interessierte - skizzieren und erläutern zu können. Die Tropen sind für ihn die Zone höchster Mannigfaltigkeit und Vielverbundenheit - oder um es mit heutigen Begriffen zum Ausdruck zu bringen: die TransArea par excellence.AbstractAlthough Alexander von Humboldt certainly perceived himself not as director of a museum, he was commited to the world of museums, libraries, and archives, not only as a visitor and reader, but also as a collector and researcher. Through his travels to America and Asia and in the course of a long

  18. Alexander von Humboldt und Carl Friedrich Gauß als Wegbereiter der neuen Disziplin Erdmagnetismus

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    Karin Reich

    2011-03-01

    Full Text Available AbstractThough Alexander von Humboldt was motivated for the first time to deal with earthmagnetism during his stay in Freiberg, it was in France that he really became a specialist in this respect. During most of his journeys he made earthmagnetic measurements. His collaboration with Arago was of great importance, it was in Paris that the first magnetic observatory was built. Humboldt rendered outstanding services to the investigation of earth magnetism by two major achievements: 1. He emphasized intensity measurements and 2. he put forward the law that the magnetic intensity is increasing from the magnetic equator toward the magnetic poles. At least since 1803 Carl Friedrich Gauss was interested in earthmagnetism and especially in Humboldt’s early published data. That Wilhelm Weber became professor of physics at the University of Göttingen in 1831 was a turning point for Gauss. In 1833 Göttingen was the centre of investigating earthmagnetism, a new era began which lasted only until 1843. Gauss’ main contributions were more or less theoretical, in 1832/3 he transformed Humboldt’s relative intensity measurements into absolute ones which were independent of the instrument’s needle. A new epoch began with Gauss’ publication „Allgemeine Theorie des Erdmagnetismus” (1839. The main point was the newly defined notion of „potential“. Gauss was the first to present the surface of the earth with equipotential lines. ZusammenfassungAlexander von Humboldt hatte sich bereits in Freiberg mit dem Erdmagnetismus beschäftigt; jedoch erst in Frankreich lernte er die entsprechenden Beobachtungsmethoden kennen. Auf allen seinen Reisen machte er erdmagnetische Messungen. Seine Zusammenarbeit mit Arago in Paris war besonders fruchtbar, hier wurde das erste magnetische Observatorium gebaut. Humboldt beschäftigte sich vor allem mit Intensitätsmessungen; sein wichtigster Beitrag war die Feststellung, dass die magnetische Intensität vom

  19. Nationwide survey of Alexander disease in Japan and proposed new guidelines for diagnosis.

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    Yoshida, Tomokatsu; Sasaki, Masayuki; Yoshida, Mari; Namekawa, Michito; Okamoto, Yuji; Tsujino, Seiichi; Sasayama, Hiroshi; Mizuta, Ikuko; Nakagawa, Masanori

    2011-11-01

    Alexander disease (AxD) is a rare neurodegenerative disorder characterized by white matter degeneration and formation of cytoplasmic inclusions. Glial fibrillary acidic protein (GFAP) mutations have been reported in various forms of AxD since 2001. However, a definitive diagnosis remains difficult because of uncertain prevalence, and different clinical features seen in infantile AxD and adult AxD may lead to confusion and misdiagnosis. Here we report an epidemiological study conducted in Japan. Two nationwide questionnaire-based surveys were conducted using tentative diagnostic criteria. We gathered information regarding prevalence, neurological findings, magnetic resonance imaging (MRI) findings, electrophysiological findings, genetic information, and the results of therapeutic interventions and home care. Prevalence of various forms of AxD was determined as 27.3% (infantile), 24.2% (juvenile), and 48.5% (adult). Prevalence of AxD in Japan was estimated to be approximately 1 case per 2.7 million individuals. The main characteristics of infantile and juvenile AxD include delayed psychomotor development or mental retardation, convulsions, macrocephaly, and predominant cerebral white matter abnormalities in the frontal lobe on brain MRI. The main characteristics of adult AxD include bulbar signs, muscle weakness with hyperreflexia, and signal abnormalities and/or atrophy of medulla oblongata and cervical spinal cord on MRI. To ensure correct diagnosis of AxD, the physician should understand the importance of the process of GFAP genetic testing, which provides definitive diagnosis. Therefore, we propose new clinical guidelines for diagnosing AxD based on simplified classifications: cerebral AxD (type 1), bulbospinal AxD (type 2), and intermediate form (type 3).

  20. Glial fibrillary acidic protein exhibits altered turnover kinetics in a mouse model of Alexander disease.

    Science.gov (United States)

    Moody, Laura R; Barrett-Wilt, Gregory A; Sussman, Michael R; Messing, Albee

    2017-04-07

    Mutations in the astrocyte-specific intermediate filament glial fibrillary acidic protein (GFAP) lead to the rare and fatal disorder, Alexander disease (AxD). A prominent feature of the disease is aberrant accumulation of GFAP. It has been proposed that this accumulation occurs because of an increase in gene transcription coupled with impaired proteasomal degradation, yet this hypothesis remains untested. We therefore sought to directly investigate GFAP turnover in a mouse model of AxD that is heterozygous for a disease-causing point mutation ( Gfap R236H /+ ) (and thus expresses both wild-type and mutant protein). Stable isotope labeling by amino acids in cell culture, using primary cortical astrocytes, indicated that the in vitro half-lives of total GFAP in astrocytes from wild-type and mutant mice were similar at ∼3-4 days. Surprisingly, results obtained with stable isotope labeling of mammals revealed that, in vivo , the half-life of GFAP in mutant mice (15.4 ± 0.5 days) was much shorter than that in wild-type mice (27.5 ± 1.6 days). These unexpected in vivo data are most consistent with a model in which synthesis and degradation are both increased. Our work reveals that an AxD-causing mutation alters GFAP turnover kinetics in vivo and provides an essential foundation for future studies aimed at preventing or reducing the accumulation of GFAP. In particular, these data suggest that elimination of GFAP might be possible and occurs more quickly than previously surmised. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  1. Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model.

    Science.gov (United States)

    Lee, So-Hyun; Nam, Tai-Seung; Kim, Kun-Hee; Kim, Jin Hee; Yoon, Woong; Heo, Suk-Hee; Kim, Min Jung; Shin, Boo Ahn; Perng, Ming-Der; Choy, Hyon E; Jo, Jihoon; Kim, Myeong-Kyu; Choi, Seok-Yong

    2017-09-07

    Alexander disease (AxD) is an astrogliopathy that predominantly affects the white matter of the central nervous system (CNS), and is caused by a mutation in the gene encoding the glial fibrillary acidic protein (GFAP), an intermediate filament primarily expressed in astrocytes and ependymal cells. The main pathologic feature of AxD is the presence of Rosenthal fibers (RFs), homogeneous eosinophilic inclusions found in astrocytes. Because of difficulties in procuring patient' CNS tissues and the presence of RFs in other pathologic conditions, there is a need to develop an in vivo assay that can determine whether a mutation in the GFAP results in aggregation and is thus disease-causing. We found a GFAP mutation (c.382G > A, p.Asp128Asn) in a 68-year-old man with slowly progressive gait disturbance with tendency to fall. The patient was tentatively diagnosed with AxD based on clinical and radiological findings. To develop a vertebrate model to assess the aggregation tendency of GFAP, we expressed several previously reported mutant GFAPs and p.Asp128Asn GFAP in zebrafish embryos. The most common GFAP mutations in AxD, p.Arg79Cys, p.Arg79His, p.Arg239Cys and p.Arg239His, and p.Asp128Asn induced a significantly higher number of GFAP aggregates in zebrafish embryos than wild-type GFAP. The p.Asp128Asn GFAP mutation is likely to be a disease-causing mutation. Although it needs to be tested more extensively in larger case series, the zebrafish assay system presented here would help clinicians determine whether GFAP mutations identified in putative AxD patients are disease-causing.

  2. The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease.

    Science.gov (United States)

    Sosunov, Alexander A; McKhann, Guy M; Goldman, James E

    2017-03-31

    Rosenthal fibers (RFs) are cytoplasmic, proteinaceous aggregates. They are the pathognomonic feature of the astrocyte pathology in Alexander Disease (AxD), a neurodegenerative disorder caused by heterozygous mutations in the GFAP gene, encoding glial fibrillary acidic protein (GFAP). Although RFs have been known for many years their origin and significance remain elusive issues. We have used mouse models of AxD based on the overexpression of human GFAP (transgenic, TG) and a point mutation in mouse GFAP (knock-in, KI) to examine the formation of RFs and to find astrocyte changes that correlate with the appearance of RFs. We found RFs of various sizes and shapes. The smallest ones appear as granular depositions on intermediate filaments. These contain GFAP and the small heat shock protein, alphaB-crystallin. Their aggregation appears to give rise to large RFs. The appearance of new RFs and the growth of previously formed RFs occur over time. We determined that DAPI is a reliable marker of RFs and in parallel with Fluoro-Jade B (FJB) staining defined a high variability in the appearance of RFs, even in neighboring astrocytes. Although many astrocytes in AxD with increased levels of GFAP and with or without RFs change their phenotype, only some cells with large numbers of RFs show a profound reconstruction of cellular processes, with a loss of fine distal processes and the appearance of large, lobulated nuclei, likely due to arrested mitosis. We conclude that 1) RFs appear to originate as small, osmiophilic masses containing both GFAP and alphaB-crystallin deposited on bundles of intermediate filaments. 2) RFs continue to form within AxD astrocytes over time. 3) DAPI is a reliable marker for RFs and can be used with immunolabeling. 4) RFs appear to interfere with the successful completion of astrocyte mitosis and cell division.

  3. Death by polonium-210: lessons learned from the murder of former Soviet spy Alexander Litvinenko.

    Science.gov (United States)

    McFee, Robin B; Leikin, Jerrold B

    2009-02-01

    The medical response to radiation--whether the result of radiological warfare, terrorist deployment of improvised radiation dispersal weapons, political assassination, occupational or industrial accidents or the medically radiated patient remains one of the least taught among all disciplines within medical education. In the aftermath of 9/11 among medical vulnerabilities to toxicant threats, of all the categories of weapons of mass destruction (WMD)--whether using the CBRNE (chemical, biological, radiological, nuclear, explosive) or NBC (nuclear, biological, chemical) acronym--radiation is the least taught in professional schools, responder cultures or civil preparedness organizations. To date, few health care professionals (HCP) possess the fundamental knowledge or skills to identify and diagnose, let alone treat a radiation victim; this vulnerability made even more obvious in the aftermath of the high profile assassination of former Russian agent Alexander Litvinenko. He was poisoned with Polonium210. Radioactive substances are ubiquitous with radiation sources being in or transported through virtually every region nationwide. It is essential to increase preparedness among community and rural health care facilities as well as urban and university hospitals. Managing radiation injuries effectively requires access to specialized equipment and expertise. Radiation sickness is progressive and may require acute, critical and long-term care throughout the course of illness. Regardless of the source, preparedness rests upon acknowledging a threat exists and dedicating the resources to address the risks including the enhancement of training and equipment. Mass or individual exposures to radiation present unique challenges to the entire response continuum from law enforcement, first responders and emergency medical care. Increased education about and practice in responding to radiological threats is essential to enhance preparedness.

  4. Statistical mechanics of /2+1 gravity from Riemann zeta function and Alexander polynomial: exact results

    Science.gov (United States)

    Kholodenko, A. L.

    2001-05-01

    In the recent publication [J. Geom. Phys. 33 (2000) 23], we have demonstrated that dynamics of /2+1 gravity can be described in terms of train tracks. Train tracks were introduced by Thurston in connection with description of dynamics of surface automorphisms. In this work, we provide an example of utilization of general formalism developed earlier. The complete exact solution of the model problem describing equilibrium dynamics of train tracks on the punctured torus is obtained. Being guided by similarities between the dynamics of two-dimensional liquid crystals and /2+1 gravity the partition function for gravity is mapped into that for the Farey spin chain. The Farey spin chain partition function, fortunately, is known exactly and has been thoroughly investigated recently. Accordingly, the transition between the pseudo-Anosov and the periodic dynamic regime (in Thurston's terminology) in the case of gravity is being reinterpreted in terms of phase transitions in the Farey spin chain whose partition function is just the ratio of two Riemann zeta functions. The mapping into the spin chain is facilitated by recognition of a special role of the Alexander polynomial for knots/links in study of dynamics of self-homeomorphisms of surfaces. At the end of paper, using some facts from the theory of arithmetic hyperbolic 3-manifolds (initiated by Bianchi in 1892), we develop systematic extension of the obtained results to noncompact Riemann surfaces of higher genus. Some of the obtained results are also useful for /3+1 gravity. In particular, using the theorem of Margulis, we provide new reasons for the black hole existence in the Universe: black holes make our Universe arithmetic, i.e. the discrete Lie groups of motion are arithmetic.

  5. Neuromechanical interference of posture on movement: evidence from Alexander technique teachers rising from a chair.

    Science.gov (United States)

    Cacciatore, Timothy W; Mian, Omar S; Peters, Amy; Day, Brian L

    2014-08-01

    While Alexander technique (AT) teachers have been reported to stand up by shifting weight gradually as they incline the trunk forward, healthy untrained (HU) adults appear unable to rise in this way. This study examines the hypothesis that HU have difficulty rising smoothly, and that this difficulty relates to reported differences in postural stiffness between groups. A wide range of movement durations (1-8 s) and anteroposterior foot placements were studied under the instruction to rise at a uniform rate. Before seat-off (SO) there were clear and profound performance differences between groups, particularly for slower movements, that could not be explained by strength differences. For each movement duration, HU used approximately twice the forward center-of-mass (CoM) velocity and vertical feet-loading rate as AT. For slow movements, HU violated task instruction by abruptly speeding up and rapidly shifting weight just before SO. In contrast, AT shifted weight gradually while smoothly advancing the CoM, achieving a more anterior CoM at SO. A neuromechanical model revealed a mechanism whereby stiffness affects standing up by exacerbating a conflict between postural and balance constraints. Thus activating leg extensors to take body weight hinders forward CoM progression toward the feet. HU's abrupt weight shift can be explained by reliance on momentum to stretch stiff leg extensors. AT's smooth rises can be explained by heightened dynamic tone control that reduces leg extensor resistance and improves force transmission across the trunk. Our results suggest postural control shapes movement coordination through a dynamic "postural frame" that affects the resistive behavior of the body. Copyright © 2014 the American Physiological Society.

  6. Project Alexander the Great: a study on the world proliferation of bioengineering/biomedical engineering education.

    Science.gov (United States)

    Abu-Faraj, Ziad O

    2008-01-01

    Bioengineering/Biomedical Engineering is considered amongst the most reputable fields within the global arena, and will likely be the primer for any future breakthroughs in Medicine and Biology. Bioengineering/biomedical engineering education has evolved since late 1950s and is undergoing advancement in leading academic institutions worldwide. This paper delineates an original study on the world proliferation of bioengineering/biomedical engineering education and bears the name 'Project Alexander the Great'. The initial step of the project was to survey all 10448 universities, recognized by the International Association of Universities, spread among the 193 member states of the United Nations within the six continents. The project aims at identifying, disseminating, and networking, through the world-wide-web, those institutions of higher learning that provide bioengineering/biomedical engineering education. The significance of this project is multifold: i) the inception of a web-based 'world-map' in bioengineering/biomedical engineering education for the potential international student desiring to pursue a career in this field; ii) the global networking of bioengineering/biomedical engineering academic/research programs; iii) the promotion of first-class bioengineering/biomedical engineering education and the catalysis of global proliferation of this field; iv) the erection of bridges among educational institutions, industry, and professional societies or organizations involved in Bioengineering/Biomedical Engineering; and v) the catalysis in the establishment of framework agreements for cooperation among the identified institutions offering curricula in this field. This paper presents the results obtained from Africa and North America. The whole project is due to be completed by 2009.

  7. Networking Knowledge. Considering Alexander von Humboldt’s Legacy in a New Shared Space in Education

    Directory of Open Access Journals (Sweden)

    Karin Lundberg

    2015-05-01

    Full Text Available Zusammenfassung Weltbürgerschaft und kulturelle Vielfalt sind überall gegenwärtige Konzepte im heutigen Bildungswesen. In den Vereinigten Staaten werden Lernziele und Kompetenzen geformt, um die Studenten gegenüber den vielen kulturellen Hintergründen, die in den Bildungsinstitutionen vorzutreffen sind, zu sensibilisieren.Trotzdem wird wahre Globalität, wie sie heute in den vielfältigen Diskursen und Perspektiven der Welt repräsentiert ist, immer noch in Lehrplänen und Studienarbeiten vernachlässigt. Dieser Artikel untersucht die Möglichkeiten, die sich heute im Bildungswesen durch den neuen, gemeinsam geteilten, globalen Bildungsraum anbieten, in dem die multikulturelle Studentenbevölkerung verschiedene Formen vernetzten Wissens und facettenreiche Perspektiven der Welt eine globale Plattform des Austausches bildet. Das von Alexander von Humboldt am Anfang des neunzehnten Jahrhunderts beschriebene universale Wissenschaftskonzept, beleuchtet solch einen vernetzten Ansatz an ein Wissen um die Welt, der auf heutige Bildungskonzepte und Kursdesigns einen positiven Einfluss nehmen könnte. Humboldts Schriften unterstreichen die Bedeutung der Inklusivität und des Wechselspiels zwischen Kulturen und Naturphänomenen. Indem wir Studenten mit unterschiedlichem kulturellen Hintergrundwissen dazu einladen, ihre jeweiligen Diskurse des Wissens aktiv zu repräsentieren, werden diese gegenseitig mit einander verknüpten Beziehungen des Wissens transparenter. Auf diese Weise, entsteht die Möglichkeit, heutige Lernziele mit neuen, produktiven Formen des Weltwissens zu berreichern, worin sich ein wahres Weltbürgertum, wie es sich in diesem neuen Bildungsraum des globalen Austausches hervortut, wiederspiegeln würde. Summary Global citizenship and diversity are well-represented concepts in today’s higher education. Learning outcomes and competencies are designed to sensitize students to the many cultural backgrounds of U.S. learning institutions

  8. What is the perceived impact of Alexander Technique lessons on health status, costs and pain management in the real life setting of an English hospital? The results of a mixed methods evaluation of an Alexander Technique service for those with chronic back pain

    OpenAIRE

    McClean, S.; Brilleman, S.; Wye, L.

    2015-01-01

    Background: Randomised controlled trial evidence indicates that Alexander Technique is clinically and cost effective for chronic back pain. The aim of this mixed methods evaluation was to explore the role and perceived impact of Alexander Technique lessons in the naturalistic setting of an acute hospital Pain Management Clinic in England.\\ud \\ud Methods: To capture changes in health status and resource use amongst service users, 43 service users were administered three widely used questionnai...

  9. Alexander disease in a dog: case presentation of electrodiagnostic, magnetic resonance imaging and histopathologic findings with review of literature.

    Science.gov (United States)

    Wrzosek, Marcin; Giza, Elżbieta; Płonek, Marta; Podgórski, Przemysław; Vandevelde, Marc

    2015-05-19

    Alexander disease is a rare neurodegenerative disorder that has not often been described in dogs. None of the existing descriptions include electrodiagnostic or magnetic resonance imaging workup. This is the first presentation of the results of an electrodiagnostic evaluation including electromyography, motor nerve conduction velocity, F-wave, the brainstem auditory evoked response and magnetic resonance imaging of a dog with Alexander disease. A six month old male entire Bernese mountain dog was presented with central nervous system symptoms of generalized tremor, general stiffness, decreased proprioceptive positioning, a reduced menace response, decreased physiological nystagmus, myotonic spasms and increased spinal reflexes which progressed to lateral recumbency. The electromyography revealed normal muscle activity and a decreased motor nerve conduction velocity, temporal dispersion of the compound muscle action potential, prolonged F-wave minimal latency, lowered F-ratio, decreased latency, and lowered amplitude of the brainstem auditory evoked potentials. The magnetic resonance imaging examination revealed ventriculomegaly and linear hyperintensity on the border of the cortical grey and white matter. The histopathological examination confirmed the presence of diffuse degenerative changes of the white matter throughout the neuraxis. A proliferation of abnormal astrocytes was found at the border between the white matter and cortex. There was also a massive accumulation of eosinophilic Rosenthal fibers as well as diffuse proliferation of abnormally large astrocytes and unaffected neurons. This is the first histopathologically confirmed case of Alexander disease in a dog with a full neurological workup. The results of the electrodiagnostic and magnetic resonance imaging examinations allow for a high-probability antemortem diagnosis of this neurodegenerative disorder in dogs.

  10. Bokan Mountain peralkaline granitic complex, Alexander terrane (southeastern Alaska): evidence for Early Jurassic rifting prior to accretion with North America

    Science.gov (United States)

    Dostal, Jaroslav; Karl, Susan M.; Keppie, J. Duncan; Kontak, Daniel J.; Shellnutt, J. Gregory

    2013-01-01

    The circular Bokan Mountain complex (BMC) on southern Prince of Wales Island, southernmost Alaska, is a Jurassic peralkaline granitic intrusion about 3 km in diameter that crosscuts igneous and metasedimentary rocks of the Alexander terrane. The BMC hosts significant rare metal (rare earth elements, Y, U, Th, Zr, and Nb) mineralization related to the last stage of BMC emplacement. U–Pb (zircon) and 40Ar/39Ar (amphibole and whole-rock) geochronology indicates the following sequence of intrusive activity: (i) a Paleozoic basement composed mainly of 469 ± 4 Ma granitic rocks; (ii) intrusion of the BMC at 177 ± 1 Ma followed by rapid cooling through ca. 550 °C at 176 ± 1 Ma that was synchronous with mineralization associated with vertical, WNW-trending pegmatites, felsic dikes, and aegirine–fluorite veins and late-stage, sinistral shear deformation; and (iii) intrusion of crosscutting lamprophyre dikes at >150 Ma and again at ca. 105 Ma. The peralkaline nature of the BMC and the WNW trend of associated dikes suggest intrusion during NE–SW rifting that was followed by NE–SW shortening during the waning stages of BMC emplacement. The 177 Ma BMC was synchronous with other magmatic centres in the Alexander terrane, such as (1) the Dora Bay peralkaline stock and (2) the bimodal Moffatt volcanic suite located ∼30 km north and ∼100 km SE of the BMC, respectively. This regional magmatism is interpreted to represent a regional extensional event that precedes deposition of the Late Jurassic – Cretaceous Gravina sequence that oversteps the Wrangellia and Alexander exotic accreted terranes and the Taku and Yukon–Tanana pericratonic terranes of the Canadian–Alaskan Cordillera.

  11. Impact of the Alexander technique on well-being: a randomised controlled trial involving older adults with visual impairment.

    Science.gov (United States)

    Gleeson, Michael; Sherrington, Catherine; Lo, Serigne; Auld, Robin; Keay, Lisa

    2017-11-01

    Older adults with visual loss have high rates of depression, restricted participation and reduced quality of life. We sought to measure the impact of lessons in the Alexander technique on vision-related emotional and social well-being, as secondary outcomes to a study on improving physical functioning in this population. This is a single-blind randomised controlled trial. One hundred and twenty community-dwelling adults aged 50 to 90 years with visual impairments were randomised to either 12 Alexander lessons over 12 weeks and usual care or usual care. The Perceived Visual Ability Scale, the Keele Assessment of Participation, the emotional subscale of the Impact of Vision Impairment Profile, the Positive and Negative Affect Scale and the five-item Geriatric Depression Scale were administered at baseline and three and 12 months. Participants were receiving services from Guide Dogs NSW/ACT. None of the validated questionnaires found statistically significant improvements after adjustment for baseline at three or 12 months, although the emotional subscale of the Impact of Vision Impairment approached significance in favour of the intervention group (4.54 points, 95 per cent CI: -0.14 to 9.21, p = 0.06). Depressive symptoms were prevalent and associated with greater impact of visual impairment on emotional well-being (odds ratio: 1.12, 95 per cent CI: 1.07 to 1.17, p Alexander technique on social and emotional well-being, although the emotional impact of visual impairment showed a trend toward less distress in the intervention group. Our data found that emotional distress associated with visual impairment influences depressive symptoms but contrary to expectations, the level of social support received was not significant. Additionally, gait speed is a significant predictor of depressive symptoms, suggesting that general mobility is of importance to the well-being of older adults with visual impairments. © 2017 Optometry Australia.

  12. Counseling and Psychotherapy Transcripts, Client Narratives, and Reference Works. A User’s Guide from Alexander Street Press

    OpenAIRE

    2011-01-01

    Представлено руководство по работе в базe Counseling and Psychotherapy Transcripts, Client Narratives, and Reference Works на английском языке издательства Alexander Street Press.

  13. The Grothendieck festschrift a collection of articles written in honor of the 60th birthday of Alexander Grothendieck

    CERN Document Server

    Cartier, Pierre; Katz, Nicholas; Manin, Yuri; Illusie, Luc; Laumon, Gérard; Ribet, Kenneth

    2009-01-01

    This three-volume work contains articles collected on the occasion of Alexander Grothendieck's sixtieth birthday and originally published in 1990. The articles were offered as a tribute to one of the world's greatest living mathematicians. Many of the groundbreaking contributions in these volumes contain material that is now considered foundational to the subject. Topics addressed by these top-notch contributors match the breadth of Grothendieck's own interests, including: functional analysis, algebraic geometry, algebraic topology, number theory, representation theory, K-theory, category theo

  14. Trasmigrazione di piante trasferimenti di concetti: la lettura scientifica ed estetica del paesaggio sud americano in Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Alexander Di Bartolo

    2013-11-01

    Full Text Available The institution of plant geography as a science in Alexander von Humboldt implies for the first time the emergence of concept of migration concerning plants and animals. But plant geography and the study on vegetation in Humboldt’s books aims to conjugate various natural sciences in order to reach an understanding of the geographical distribution of vegetation. A new approach in South American analysis, connected with an aestethic lecture of Tropical lands of New Word, redefines the idea of “New” thanks to use of analogic concepts based on science and European aestethic lexicon.

  15. Alexander von Humboldt” als Name für Forschungsschiffe vor dem Hintergrund seiner meereskundlichen Arbeiten

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    Gerhard Kortum

    2002-10-01

    Full Text Available Article in German, Abstract in English. A. v. Humboldt as a Name of Research VesselsA number of special purpose vessels in the world carried or carry the name of Alexander von Humboldt, who had substantial interests in oceanography. However, most of his marine texts are scattered over his major works, and he never finished his manuscript on ocean circulation. But there is a general agreement that A. v. Humboldt was one of the pioneers of marine sciences. He made his own observations on the sailing vessels he used on his expedition to the Neotropics, mainly concerning sea surface temperatures. In 2002 there was a discussion in Germany about the name of a new research vessel which is going to be commissioned in the summer of 2004. It was suggested by the science community to take the name of „Alexander von Humboldt“ again, as the new vessel is replacing a medium-sized ship with this name operated now by the Baltic Sea Research Institute in Rostock-Warnemünde. This vessel has been in service from 1970 to 1990 for the Academy of Sciences of the former German Democratic Republic. The first German research vessel „Alexander von Humboldt“ was a fishing trawler (1939. Furthermore, Peru and Mexico operate research vessels bearing Humboldt’s name. The best known „Alexander von Humboldt“ is an ocean going sailing ship of the International Sail Training Association, based in Bremen. She is engaged in educational programmes and went the South America in 1999 following Humboldt’s route. Thus, Humboldt’s marine legacy is preserved. The proposal to use the undisputed name of this great all-round scientist for the new German vessel under construction now was not successful. A high-ranking jury decided to prefer “Maria Sibylla Merian” (1647-1717, which was suggested by a young student in a nation-wide competition to find a name. As Humboldt 100 years later, she went to South America to study plants and other fields of natural history.

  16. The Synaxarion Redaction of the Life of St. Alexander Svirsky: A Reconstruction of the Early Stages of the Text History

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    Alexandra E. Soboleva

    2016-08-01

    Full Text Available The paper addresses the problems of the attribution and the geographical and chronological origins of the synaxarion redaction of the Life of St. Alexander Svirsky; it relies on textological, codicological, and palaeographic analysis of the surviving manuscripts. The author draws some conclusions about the formation of the regional variants of this medieval hagiographic text. Alexander Svirsky was the only Christian saint who was honored by receiving a manifestation of the Holy Trinity; this occurred in 1508. He founded the monastery of the Holy Trinity and was its archpriest until his dormition in 1533. The Life of Alexander Svirsky was written in 1545 by Herodion Kochnev, one of the saint’s acolytes, at the directive of Metropolitan Macarius for the Great Menaion Reader. The Life of St. Alexander Svirsky survives in a large number of copies— about 200—from the 16th and 17th centuries. Only nine of these copies show the text variant that the author of this study calls “the synaxarion variant”; they appear in synaxaria from the second half of the 16th and the beginning of the 17th centuries. Word-by-word text comparison allows one to conclude that these nine copies fall into three different redactions, each reflecting Herodion’s text. All three redactions originate from different areas, and they differ in subject matter and in the methods of elaboration of the Menaion text. On the one hand, this confirms that obviously there was a great need for this kind of text; on the other hand, it acknowledges the absence of a norm by means of which such texts might be compiled. The first, earliest, synaxarion redaction survives in seven copies, including one of the earliest copies of the Life, which dates back to 1549, according to a note by the scribe. It might have been created soon after Herodion’s text for the Great Menaion Reader to coincide with Alexander’s canonization in 1547. Despite the small number of surviving copies, this

  17. Connecting the New World. Nets, mobility and progress in the Age of Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Moritz von Brescius

    2012-12-01

    Full Text Available Zusammenfassung Dieser Artikel untersucht das Verhältnis zwischen den revolutionären technologischen Neuerungen des 19. Jahrhunderts und dem Leben und Wirken Alexander von Humboldts (1769-1859. Dabei wird gefragt, wie Humboldt versuchte, die neuen und sprichwörtlich bahnbrechenden Kommunikations- und Transporttechnologien seiner Zeit zu nutzen, um den amerikanischen Kontinent in globale kommerzielle und kulturelle Austauschprozesse zu integrieren. Jüngere Forschungen zu Humboldts amerikanischer Expedition (1799-1804 haben behauptet, dass seine Beschreibungen Südamerikas den Kontinent für zahlreiche „transformative interventions“ (Pratt von Seiten europäischer Kapitalisten und Investoren zugänglich gemacht hätten. Diese Studien haben jedoch nicht analysiert, aus welchen Motiven heraus Humboldt diese Eingriffe in die Natur unterstützte. Darüber hinaus wurde nicht der zentralen Frage nachgegangen, welche Rolle diese Projekte in Humboldts eigener Auffassung über die Kräfte des gesellschaftlichen Fortschritts gespielt haben. Um Humboldts Unterstützung für tiefgreifende Eingriffe in die Natur Amerikas nachvollziehen zu können, analysiert dieser Artikel zunächst, welche Rolle der „Geodeterminismus“ und die Fortschrittstheorien der Aufklärung in seinem Verständnis von zivilisatorischer Entwicklung spielten. Dabei sollen solche Beispiele menschlicher Interventionen in die Natur Amerikas untersucht werden, die Humboldt selbst aktiv förderte – nicht zuletzt, da sie geeignet schienen, „natürliche“ Barrieren für gesellschaftliche Austauschprozesse zu beseitigen. Dies waren vor allem die Nutzung von Dampfschiffen, elektrischer Telegrafie, Eisenbahnen und großangelegten Kanalprojekten, deren gebündelte Effekte zu einer signifikanten Beschleunigung von Welthandel und Kommunikationsprozessen führten. Diese zeitgenössischen Innovationen sollen mit den vier Motiven „Netz“, „Mobilität“, „Fortschritt“ und

  18. [Follow-up and genetic study of 43 Chinese children with type Ⅰ Alexander disease].

    Science.gov (United States)

    Ban, T T; Wu, Y; Zhang, Z B; Zang, L L; Wang, J M; Jiang, Y W

    2017-07-02

    Objective: To identify the clinical and genetic characteristics in 43 Chinese children diagnosed with type Ⅰ Alexander disease (AxD). Method: Forty-three type Ⅰ AxD cases identified by glial fibrillary acidic protein (GFAP) gene mutations in Peking University First Hospital from 2005 to 2016 were followed up. The data of medical history, physical examination and magnetic resonance imaging (MRI) were collected. All these patients were followed up in December 2010, Febury 2012, June 2014 and January 2016, respectively. Result: Forty-three patients were genetically confirmed as type I AxD and the median age at the last visit was 11.71 years (10.27, 13.15). The characteristic clinical manifestations of these type Ⅰ AxD patients were developmental delay (79%, 34/43), seizures (86%, 37/43), macrocephaly (the median percentile of head circumference is 90%), and paroxysmal deterioration (27%, 13/43). All the 43 patients' brain MRI satisfied typical MRI features proposed by van der Knaap. According to the analysis of the long-term follow-up, patients with type Ⅰ AxD began to have obvious regression in motor function after 7 years of age, and the social life ability was milally impaired 8(6, 10)scores at the last follow-up. Seventeen heterozygous missense mutations of GFAP were identified in 43 genetically confirmed patients, and 4 mutations were novel. The mutations in 41 patients (95%, 41/43) were de novo. Three hot spots of mutation in Chinese patients were found: p. Arg239(35%, 15/34), p. Arg79 (26%, 11/43) and p. R88 (16%, 7/43). Conclusion: The characteristic clinical manifestations of type Ⅰ AxD patients are developmental delay, seizures, macrocephaly and paroxysmal deterioration. Moreover, a few patients may present with brain stem symptoms, mental abnormalities, scoliosis or kyphosis. Patients with type Ⅰ AxD may show significant regression in motor function after 7 years of age.

  19. Alexander Mikhailovich Zakharov and his works on the venom apparatus and venoms of some poisonous snakes

    Directory of Open Access Journals (Sweden)

    Cherlin Vladimir Alexandrovich

    2013-10-01

    Full Text Available The article gives brief biographical information about a very talented herpetologist Alexander M. Zakharov, and describes the general results of his works on the structure and function of venom glands of some poisonous snakes and their venoms. In his studies, he got the results, which are fundamentally different from the conventional concept of 30s - 70s of the XX century. Unfortunately, among physicians this concept has not changed up today. At that time it was thought that the poisons of Viperidae snakes are almost completely hemotoxic, and poisons of Elapidae (cobra are almost neurotoxic. But A.M.Zaharov found out, that poisons of both types of snakes (Viperidae and Elapidae include three groups of substances: hemotoxins, neurotoxins and non-toxic component – hyaluronidase. Each of these groups of substances is produced by independent part of venom glands and has its own special effect. Neurotoxins act on the central nervous system (mainly the respiratory center, but are greatly destroyed by means of the blood antigen properties and cannot pass through the hematoencephalic barrier. Hyaluronidase , connecting with neurotoxins, has an important property – to "smuggle" neurotoxins through the hematoencephalic barrier exactly into the target organ – the respiratory center in the central nervous system. In this case, neurotoxin enters the respiratory center not through the blood and lymph vessels, but directly through the nerve channel, through synapsis. The main function of hemotoxins is not to kill the victim, but to protect neurotoxins and hyaluronidase from the destructive activity of the victim's blood. Therefore, the target of the poisons of Viperidae and Elapidae snakes is the central nervous system of victims, but Elapidae has almost no hemotoxins. That’s why their striking effect can be achieved only by a strong increase in the amount of neurotoxins and hyaluronidase. Hemotoxins of Viperidae venoms permits to reduce the amount of

  20. Adult-onset Alexander disease: a series of eleven unrelated cases with review of the literature.

    Science.gov (United States)

    Pareyson, Davide; Fancellu, Roberto; Mariotti, Caterina; Romano, Silvia; Salmaggi, Andrea; Carella, Francesco; Girotti, Floriano; Gattellaro, Grazietta; Carriero, Maria Rita; Farina, Laura; Ceccherini, Isabella; Savoiardo, Mario

    2008-09-01

    Alexander disease (AD) in its typical form is an infantile lethal leucodystrophy, characterized pathologically by Rosenthal fibre accumulation. Following the identification of glial fibrillary acidic protein (GFAP) gene as the causative gene, cases of adult-onset AD (AOAD) are being described with increasing frequency. AOAD has a different clinical and neuroradiological presentation with respect to early-onset AD, as abnormalities are mainly concentrated in the brainstem-spinal cord junction. We report detailed clinical and genetic data of 11 cases of AOAD, observed over a 4-year period, and a review of the previously reported 25 cases of genetically confirmed AOAD. In our series, onset occurred as late as age 62, and up to 71 in an affected deceased relative. Most cases appeared sporadic, but family history may be misleading. The most frequent symptoms were related to bulbar dysfunction-with dysarthria, dysphagia, dysphonia (seven patients)-, pyramidal involvement (seven patients) and cerebellar ataxia (seven patients). Four patients had palatal myoclonus. Sleep disorders were also observed (four cases). Bulbar symptoms, however, were infrequent at onset and two symptomatic patients had an almost pure pyramidal involvement. Two subjects were asymptomatic. Misdiagnosis at presentation was frequent and MRI was instrumental in suggesting the correct diagnosis by showing, in all cases, mild to severe atrophy of the medulla oblongata extending caudally to the cervical spinal cord. In ten patients, molecular studies revealed six novel missense mutations and three previously reported changes in GFAP. The last typical patient carried no definitely pathogenic mutation, but a missense variant (p.D157N), supposedly a rare polymorphism. Revision of the literature and the present series indicate that the clinical picture is not specific, but AOAD must be considered in patients of any age with lower brainstem signs. When present, palatal myoclonus is strongly suggestive

  1. Teachers of the Alexander Technique in the UK and the people who take their lessons: A national cross-sectional survey.

    Science.gov (United States)

    Eldred, J; Hopton, A; Donnison, E; Woodman, J; MacPherson, H

    2015-06-01

    Given the rising profile of the Alexander Technique in the UK, there is a need for a comprehensive description of its teachers and of those who currently take lessons. In a national survey of Alexander teachers, we set out to address this information gap. A cross-sectional survey of 871 UK members of three main Alexander Technique teachers' professional associations was conducted. A questionnaire requested information about their professional background, teaching practice and methods, and about the people who attend lessons and their reasons for seeking help. With an overall response rate of 61%, 534 teachers responded; 74% were female with median age of 58 years, 60% had a higher education qualification, and 95% were self-employed, many with additional non-Alexander paid employment. The majority (87%) offered lessons on their own premises or in a privately rented room, and 19% provided home visits; both individual and group lessons were provided. People who took lessons were predominantly female (66%) with a median age of 48 years, and 91% paid for their lessons privately. Nearly two-thirds (62%) began lessons for reasons related to musculoskeletal conditions, including back symptoms, posture, neck pain, and shoulder pain. Other reasons were general (18%, including well-being), performance-related (10%, including voice-, music-, and sport-related), psychological (5%) and neurological (3%). We estimate that Alexander teachers in the UK provide approximately 400,000 lessons per year. This study provides an overview of Alexander Technique teaching in the UK today and data that may be useful when planning future research. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. [Analysis of the plaster casts of Class II division 1 non-extraction patients treated with Alexander technique].

    Science.gov (United States)

    Cao, Tian; Wei, Song; Zhou, Yan-heng

    2013-09-01

    To investigate the changes of arch width and arch length in Class II division 1 non-extraction patients treated with Alexander technique. Dental casts of 21 Class II division 1 non-extraction patients treated with Alexander appliance were taken before (T1) and after treatment (T2). All the casts were laser scanned. The arch width and arch length were digitally measured. The differences of arch width and arch length between T1 and T2 were recorded and analyzed. The upper arch length decreased from (32.82 ± 2.51) mm to (31.97 ± 2.17) mm (P < 0.05). The lower arch length increased from (27.53 ± 2.61) mm to (28.80 ± 1.81) mm (P < 0.05). The intercanine width in the upper arch changed significantly from T1 to T2. The intermolar width in the upper and lower arches increased significantly from T1 to T2. Class II division 1 non-extraction patients could be treated successfully by increasing the upper arch width.

  3. „Vater einer großen Nachkommenschaft von Forschungsreisenden ...“ Ehrungen Alexander von Humboldts im Jahre 1869

    Directory of Open Access Journals (Sweden)

    Ilse Jahn

    2004-04-01

    Full Text Available Article in German, Abstracts in English and GermanIn 1869 the “Naturwissenschaftlicher Verein” was founded in Magdeburg (Saxony Anhalt. That was the time when the scientific world celebrated Alexander von Humboldt’s 100th birthday. In this context, Humboldt’s achievements were remembered during the founding ceremony of that society. The paper which was read in September 2003 on a meeting of this organisation, focuses on three famous naturalists who celebrated Humboldt because they owed him much help in their own professional careers. The botanist Matthias Jacob Schleiden gave a memorial speech in 1869 in Dresden. The physiologist and pioneer of electro-biology Emil du Bois-Reymond honoured his mentor A. v. Humboldt on the occasion of the dedication of the statues of Wilhelm and Alexander in 1883 in Berlin. Charles Darwin expressed his gratitude to Humboldt by sending him in 1839 the report of his travels and received an interesting reply. These three scholars represented a new epoch in the development of the natural sciences. The paper includes a recently re-discovered letter from Humboldt to Schleiden, dated April 13, 1842.

  4. Recasting the Significant: The Transcultural Memory of Alexander von Humboldt’s Visit to Philadelphia and Washington, D.C.

    Directory of Open Access Journals (Sweden)

    James F. Howell

    2016-07-01

    Full Text Available Alexander von Humboldt was internationally known as a world traveler, having collected data and analyzed samples from five of the world’s seven continents. He spoke several languages fluently, and split most of his adult life between the cosmopolitan centers of Berlin and Paris. The great deal of time Humboldt spent in Latin America, along with his staunch belief in human equality, led to his reverence in those countries. Indeed, Humboldt was a world citizen in the truest sense of the word. But what of the United States? What claim can this nation make to the heritage and legacy of the world-exploring baron? A brief stop in Philadelphia and Washington, D.C. at the end of Humboldt’s expedition to the equatorial regions of the Americas seems to suffice. This short stay, along with the Humboldt-Jefferson correspondence, constitutes the great American link in Humboldt studies, a link whose nature and importance has, over the years, received an exaggerated amount of attention from authors writing for an American audience. The following analysis, using the tools of transcultural memory studies, investigates why this relatively insignificant event in a long and storied life assumes an inflated role in current accounts of the life and work of Alexander von Humboldt.

  5. The metallogeny of Late Triassic rifting of the Alexander terrane in southeastern Alaska and northwestern British Columbia

    Science.gov (United States)

    Taylor, C.D.; Premo, W.R.; Meier, A.L.; Taggart, J.E.

    2008-01-01

    A belt of unusual volcanogenic massive sulfide (VMS) occurrences is located along the eastern margin of the Alexander terrane throughout southeastern Alaska and northwestern British Columbia and exhibits a range of characteristics consistent with a variety of syngenetic to epigenetic deposit types. Deposits within this belt include Greens Creek and Windy Craggy, the economically most significant VMS deposit in Alaska and the largest in North America, respectively. The occurrences are hosted by a discontinuously exposed, 800-km-long belt of rocks that consist of a 200- to 800-m-thick sequence of conglomerate, limestone, marine elastic sedimentary rocks, and tuff intercalated with and overlain by a distinctive unit of mafic pyroclastic rocks and pillowed flows. Faunal data bracket the age of the host rocks between Anisian (Middle Triassic) and late Norian (late Late Triassic). This metallogenic belt is herein referred to as the Alexander Triassic metallogenic belt. The VMS occurrences show systematic differences in degree of structural control, chemistry, and stratigraphic setting along the Alexander Triassic metallogenic belt that suggest important spatial or temporal changes in the tectonic environment of formation. At the southern end of the belt, felsic volcanic rocks overlain by shallow-water limestones characterize the lower part of the sequence. In the southern and middle portion of the belt, a distinctive pebble conglomerate marks the base of the section and is indicative of high-energy deposition in a near slope or basin margin setting. At the northern end of the belt the conglomerates, limestones, and felsic volcanic rocks are absent and the belt is composed of deep-water sedimentary and mafic volcanic rocks. This northward change in depositional environment and lithofacies is accompanied by a northward transition from epithermal-like structurally controlled, discontinuous, vein- and pod-shaped, Pb-Zn-Ag-Ba-(Cu) occurrences with relatively simple mineralogy

  6. Alexander von Humboldt brachte Guano nach Europa - mit ungeahnten globalen Folgen

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    Bärbel Rott

    2016-05-01

    Full Text Available Zusammenfassung Die vorliegende Abhandlung beschäftigt sich mit einem bisher wenig beachteten Aspekt von Humboldts Amerikanischer Reise (1799─1804. Während seine Studien der Pflanzen- und Tierwelt bis heute große Aufmerksamkeit genießen, wird Humboldts Beitrag zu der Entwicklung der modernen Landwirtschaft wenig beachtet. Während seines Aufenthalts in Lima erhielt er Proben von Guano, Vogelmist von den Chincha-Inseln vor der peruanischen Küste. Einige Proben, die er von dieser Reise zurückbrachte, wurden von Wissenschaftlern in Frankreich und Deutschland untersucht. Die Analysenergebnisse zeigten außerordentlich hohe Gehalte an Pflanzennährstoffen, insbesondere Stickstoff und Phosphor. In den folgenden Jahrzehnten wurde Guano zu einem bedeutsamen Düngemittel und Auslöser eines Booms in Europa und Peru. Die Auswirkungen dieser Entwicklung sind bis heute sichtbar und werden hier unter besonderer Beachtung von Phosphor beschrieben. Abstract One aspect of Humboldt’s travel to South America (1799─1804 received little attention. The fascination of his studies of the South American flora and fauna is unbroken to the present day. Yet Humboldt’s contribution to modern agriculture remains almost unnoticed. During his stay in Lima Humboldt received samples of guano, a mixture of bird droppings from the Chincha Islands off the Peruvian coast, which he took to Europe and had analyzed by the most famous chemists in France and Germany. The results showed outstanding fertilizing effects, in particular due to the high content of nitrogen and phosphorus. The ensuing boom starting from the 1840s influenced agriculture in Europe and the economy of Peru seriously. Some aspects of this historical development may give an idea of the ensuing change not only in agriculture. Résumé Il y a un aspect du voyage de Alexander von Humboldt en Amérique du Sud (1799─1804 qui jusqu’à présent a été peu considéré. Ses études de la flore at le da

  7. Infantile-onset Alexander disease in a child with long-term follow-up by serial magnetic resonance imaging: a case report.

    Science.gov (United States)

    Nishibayashi, Fumiko; Kawashima, Miho; Katada, Yoshiaki; Murakami, Nobuyuki; Nozaki, Miwako

    2013-07-26

    Alexander disease is a rare disorder resulting from a glial fibrillary acidic protein gene mutation which causes progressive degeneration of white matter. With the usual poor prognosis, there are few case reports with long-term follow-up. We report the five-year clinical course of Alexander disease in one case using serial magnetic resonance imaging. A 12-month-old Japanese male was referred to the pediatrics department in our hospital because of developmental retardation. Alexander disease was diagnosed by gene examination of the mutation of a glial fibrillary acidic protein. Magnetic resonance imaging findings showed abnormalities in white matter, deep gray matter, and medulla oblongata. Serial magnetic resonance imaging examinations until the age of five were performed and changes in magnetic resonance imaging findings were compared to the progression in clinical symptoms. Alexander disease is a very rare disease with a variety of clinical phenotypes. Therefore serial magnetic resonance imaging studies for long-term survival infantile cases including our case may be important in the analysis of the pathophysiological mechanism.

  8. Functional characterization of a GFAP variant of uncertain significance in an Alexander disease case within the setting of an individualized medicine clinic.

    Science.gov (United States)

    Boczek, Nicole J; Sigafoos, Ashley N; Zimmermann, Michael T; Maus, Rachel L; Cousin, Margot A; Blackburn, Patrick R; Urrutia, Raul; Clark, Karl J; Patterson, Marc C; Wick, Myra J; Klee, Eric W

    2016-09-01

    A de novo GFAP variant, p.R376W, was identified in a child presenting with hypotonia, developmental delay, and abnormal brain MRI. Following the 2015 ACMG variant classification guidelines and the functional studies showing protein aggregate formation in vitro, p.R376W should be classified as a pathogenic variant, causative for Alexander disease.

  9. Late-onset Alexander disease with a V87L mutation in glial fibrillary acidic protein (GFAP) and calcifying lesions in the sub-cortex and cortex.

    Science.gov (United States)

    Suzuki, Hidekazu; Yoshida, Tomokatsu; Kitada, Mari; Ichihashi, Juri; Sasayama, Hiroshi; Nishikawa, Yoshiro; Mistui, Yoshiyuki; Nakagawa, Masanori; Kusunoki, Susumu

    2012-03-01

    Glial fibrillary acidic protein (GFAP) mutation has been reported in Alexander disease. We report a 31-year-old woman suffering from Alexander disease with a V87L mutation in GFAP. She showed psychomotor regression and a history of seizures, in addition to pendular nystagmus, dysarthria, spastic gait, and bladder dysfunction. Brain magnetic resonance imaging (MRI) showed atrophy of the medulla oblongata and mild cervical cord atrophy, deep white matter abnormalities, periventricular rim, and signal changes of the medulla oblongata and dentate hilum. Sequence analysis of her GFAP gene showed a heterozygous c.273G>C mutation predictive of a p.V87L amino acid substitution. We concluded that she was actually affected with Alexander disease. Twenty months later she fell down and sustained a head contusion. Urgent head computed tomography (CT) showed calcification in the subcortical and cortical regions, which may relate to the psychomotor regression and history of seizures. Calcification in the subcortical and cortical regions on head CT has not been reported in Alexander disease; this may be associated with a V87L mutation in GFAP.

  10. Alexander Graham Bell's Patent for the Telephone and Thomas Edison's Patent for the Electric Lamp. The Constitution Community: The Development of the Industrial United States (1870-1900).

    Science.gov (United States)

    Schur, Joan Brodsky

    In 1876 Americans held a Centennial Exhibition in Philadelphia (Pennsylvania) to celebrate the nation's birth 100 years earlier. Machinery Hall drew the most admiration and wonder. Alexander Graham Bell exhibited the first telephone, and Thomas Alva Edison presented the automatic telegraph, one of more than 1,000 inventions he would patent in his…

  11. Discuss: If Essays Are Dead, Then Where Does That Leave Everything Else? A Response to: Shirley Alexander's "Buying Essays: How to Make Sure Assessment Is Authentic"

    Science.gov (United States)

    McQueen, Kelvin

    2015-01-01

    Professor Shirley Alexander is the Deputy Vice-Chancellor and Vice-President (Teaching, Learning & Equity) at the University of Technology, Sydney. On 12 November 2014, an article of hers appeared in "The Conversation": "Buying essays: how to make sure assessment is authentic." That article traverses, in an abbreviated way,…

  12. Jade aus Amerika und weitere Grünsteinobjekte von Alexander von Humboldt aus dem Berliner Mineralienkabinett

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    Renate Nöller

    2002-04-01

    Full Text Available Article in German, Abstracts in English, Spanish and German.Alexander von Humboldt sent samples of minerals from America not only for scientific or economic purposes. We also find carved pieces made out of green stone material known as Jade, that has been culturally very important in Mesoamerica. In Europe these green stone objects have been treated differently. The Jade-Celt and the Sun-Disc - known as “Humboldt-Axt” and “Humboldt-Scheibe” - both lost during the second world war, had gained great interest, whereas a small head-pendant - made out of Jade has been totally forgotten. The samples reflect the understanding of their worth in distinct cultural contexts.

  13. James Sowerby: meteorites and his meteoritic sword made for the Emperor of Russia, Alexander I, in 1814

    Science.gov (United States)

    Henderson, Paul

    2013-01-01

    James Sowerby included meteorites in his publications of British and exotic natural history and so raised interest in their nature and origins at a time of much debate and involving the President of the Royal Society, Sir Joseph Banks. The celebrations over the defeat of France in 1814 prompted Sowerby to make a sword from the Cape of Good Hope iron meteorite to present to the Russian Emperor, Alexander I, at the time of his state visit to London in June 1814 and in recognition of his achievements in bringing peace to Europe. The story of its attempted presentation, its final reception and the following response, including publications, all helped to increase interest in meteorites and their properties. The rediscovery of the sword after a lengthy disappearance probably brings an unusual saga to a fitting close.

  14. "The Waters I am Entering No One yet Has Crossed": Alexander Friedman and the Origins of Modern Cosmology

    CERN Document Server

    Belenkiy, Ari

    2013-01-01

    Ninety years ago, in 1922, Alexander Friedman (1888-1925) demonstrated for the first time that the General Relativity equations admit non-static solutions and thus the Universe may expand, contract, collapse, and even be born. The fundamental equations he derived still provide the basis for the current cosmological theories of the Big Bang and the Accelerating Universe. Later, in 1924, he was the first to realize that General Relativity allows the Universe to be infinite. Friedman's ideas initially met strong resistance from Einstein, yet from 1931 he became their staunchest supporter. This essay connects Friedman's cosmological ideas with the 1998-2004 results of the astronomical observations that led to the 2011 Nobel Prize in Physics. It also describes Friedman's little known topological ideas of how to check General Relativity in practice and compares his contributions to those of Georges Lemaitre. Recently discovered corpus of Friedman's writings in the Ehrenfest Archives at Leiden University sheds some ...

  15. The evolution of ultrahigh carbon steels - from the Great Pyramids, to Alexander the Great, to Y2K

    Energy Technology Data Exchange (ETDEWEB)

    Wadsworth, J

    1999-10-01

    Hypereutectoid steels containing between about 1 and 2.1 wt%C, and now known as ultrahigh carbon steels (UHCS), have both a rich history (dating back to the time of Alexander the Great, i.e. {approximately} 300 BC) and an interesting, recent, technological period of development (from 1975 to the present). The connections between the modern UHCS and their ancient counterparts, and in particular Damascus steels, have received considerable attention. In addition to monolithic products, UHCS have also been used in both ancient and modern times in laminated composites. In the present paper, a summary of the modern development of UHCS and UHCS-containing laminates is given, and parallels are drawn with ancient materials. Also, ancient laminated composites containing other steels are described; controversial issues and a possible solution related to the age of such a laminate found in the Great Pyramid of Gizeh are discussed.

  16. Hallar e inventar a un público. Nuevos proyectos editoriales acerca de la obra de Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Ottmar Ette

    2008-10-01

    Full Text Available Article in español, abstracts in englisch, español and german.In Latin America, Alexander von Humboldt was and is known as one of the most famous historic and literary figures; in his own country, though, the acquaintance with his texts has until the 80s been reduced to groups of specialized scholars. Yet, for a couple of years, a growing interest in the works of Humboldt can be noticed, based on numerous new editions, which have been published since. Among others, these are the new edition of the Relation historique (1991, the editions of the „Humboldt Project“ (2004-2006 as part of the „Andere Bibliothek“, as well as current projects on German editions concerning Asie Centrale and the Examen critique.

  17. Non-Euclidean Space, Movement and Astronomy in Modern Art: Alexander Calder's Mobiles and Ben Nicholson's Reliefs

    Science.gov (United States)

    Malloy, Vanja

    2013-09-01

    John Keats once wrote that `there is no such thing as time and space' rather, believing that time and space are mental constructs that are subject to a variety of forms and as diverse as the human mind. In the 1920s through the 1930s, modern physics in many ways supported this idea through the various philosophical writings on the Theory of General Relativity to the masses by scientists such as Arthur Eddington and Albert Einstein. These new concepts of modern physics fundamentally changed our understanding of time and space and had substantial philosophical implications, which were absorbed by modern artists resulting in the 1936 Dimensionist Manifesto. Seeking to internalize the developments of modern science within modern art, this manifesto was widely endorsed by the most prominent figures of the avant-garde such as Marcel Duchamp, Jean Arp, Naum Gabo, Joan Miró, László Moholy-Nagy, Wassily Kandinsky and Alexander Calder. Of particular interest to this manifesto was the new concept of the fourth-dimension, which in many ways revolutionized the arts. Importantly, its interpretation varied widely in the artistic community, ranging from a purely physical four-dimensional space, to a kinetic concept of space in which space and time are linked, to a metaphysical interest in a space that exists beyond the material realm. The impact of modern science and astronomy on avant-garde art is currently a bourgeoning area of research with considerable implications to our rethinking of substantial artistic figures of this era. Through a case study of Alexander Calder's Mobiles and Ben Nicholson's Reliefs, this paper explores how these artworks were informed by an interest in modern science.

  18. Steers performance fed diets with Alexander grass silage (Urochloa plantaginea x sorghum silage (Sorghum bicolor (L. Moench

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    Flânia Mônego Argenta

    2014-02-01

    Full Text Available This study aimed to evaluate the parameters related to feedlot beef steers fed with Alexander grass silage or sorghum silage as roughage source. Twelve animals with initial average of weight and age of 245 kg and 20 months, respectively, belonging to Nellore (N, Charolais (C, 21/32 N 11/32 C, 21/32 C 11/32 N; 43/64 N 21/64 C and 43/64 C 21/64 N genetic groups were used. The ration was composed by a roughage:concentrate relation of 50:50 (dry matter basis, offered at ease. The dry matter, crude protein, ether extract, neutral detergent fiber and acid detergent fiber daily intake didn’t differ between roughage sources, being the medium values of 10.18; 1.28; 0.20; 4.96 and 2.51 kg/day, respectively. However, the ether extract intake by metabolic size and by corporal weight percentage were higher for the one that consumed sorghum silage, obtaining values of 2.74 and 2.36 g/metabolic size and 0.06 and 0.05 kg/100 kg of live weight. The same behavior was observed for digestible energy intake, presenting values of 364.87 and 302.83 g/metabolic size and 8.10 and 7.02 kg/100 kg of live weight. The daily average gain, final corporal score and feed conversion weren’t influenced by roughage type, being the values of 1.31 kg; 4.05 points and 7.78 kg of DM/kg of weight gain, respectively. The Alexander grass silage is a feasible alternative as its substitution in relation to sorghum silage.

  19. Alexander I, Napoleon and Franco-Russian relations | Alexandre Ier, Napoléon et les relations franco-russes

    Directory of Open Access Journals (Sweden)

    Marie-Pierre Rey

    2011-12-01

    Full Text Available Educated in the spirit of the Enlightenment, upon his accession to the throne in March 1801, Alexander I, intending to reform his empire, gave priority to domestic issues; but very quickly, foreign policy came to dominate the agenda, and his duel with Napoleon wholly absorbed his energies. Because of the ambivalence of the Tilsit alliance, Russian-French relations continuously deteriorated after 1807, leading to the 1812 tragedy. Vanquisher of Napoleon, the tsar who has been transformed by the ordeal (he became religious, became anxious to rebuild the European continent on a new basis. This explains the personal role he played during the Vienna Congress and the project of Holy Alliance that he encouraged. But by 1820-21, Alexander became more and more paranoiac in his political views and the Holy Alliance has been transformed into a tool to repress liberal ideas in the service of conservative regimes. | Alejandro I, entronizado en marzo de 1801 y educado en el espíritu de las Luces, toma conciencia de la necesidad de reformar el imperio dando prioridad a las cuestiones internas; pero pronto la política exterior le absorbe totalmente, de forma que su reinado quedará marcado por el enfrentamiento con Napoleón. La alianza de Tilsit se revela ambigua y las relaciones franco-rusas se degradan hasta la tragedia de 1812. El zar, que salió victorioso y transformado de la prueba –se volvió profundamente religioso–, hace sentir su peso en la reconstrucción del continente europeo, jugando un papel personal importante en el Congreso de Viena y en Tratado de la Santa Alianza. Sin embargo, desde 1820-1821 Alejandro I tiene una visión del mundo cada vez más paranoica, y la Santa Alianza se convierte en una herramienta represiva al servicio del absolutismo.

  20. Experiment und Wissensvermittlung. Alexander von Humboldts Darstellungsmethoden in seinen Versuchen über die gereizte Muskel- und Nervenfaser

    Directory of Open Access Journals (Sweden)

    Alexander Stöger

    2016-11-01

    Full Text Available Zusammenfassung Alexander von Humboldt hat sich in jungen Jahren mit galvanischen Experimenten beschäftigt und die Resultate in einem umfassenden, zweibändigen Werk publiziert. Dabei zeigte er nicht nur, dass er als Experimentator und Teil der wissenschaftlichen Gemeinschaft fähig war, sich mit einem so neuen und komplexen Phänomen zu beschäftigen. Es lässt sich auch erkennen, dass er bereits in dieser frühen Schrift versuchte, das umfangreiche Wissen dem Leser zugänglich zu machen. Der Artikel betrachtet Humboldts Galvanismusschrift Versuche über die gereizte Muskel- und Nervenfaser (1797–1798 und untersucht einige Elemente wie Anhänge und Schreibstil, die Humboldt nutzte, um die umfangreichen Informationen zu ordnen und dem Leser so neben den Big Data seiner Erkenntnisse auch passende Suchfunktionen zur Verfügung zu stellen, die eine gezielte Nutzung überhaupt ermöglichen.  Abstract In the early stages of his scientific career, Alexander von Humboldt took an interest in experiments in galvanism. He publicised the results in a two-volume work under the title Versuche über die gereizte Muskel- und Nervenfaser (Experiments on the Stimulated Muscle and Nerve Fibre in 1797 and 1798. In this treatise, he presented himself as competent experimenter and member of the scientific community, but also demonstrated that he was capable of researching new and complex phenomena. These volumes also provide insight into his early attempts to facilitate the readers’ access to the extensive information he had compiled. This article analyses some aspects of Humboldt’s efforts to arrange his vast numbers of observations and theories, for example by means of appendices and narrative style, which he used not only to present the resulting big data collected during his research, but also to make it possible for the reader to organise and utilise this data.   Resumen A temprana edad Alexander von Humboldt se dedicó a galvanismo. En 1797 y 1798

  1. "SO YOU ARE RIGHT, THE ORACLE OF FRANCE...": ALEXANDER PUSHKIN'S POEM "RUSLAN AND LUDMILA" WITHIN THE FRAMEWORK OF RUSSIAN HISTORY OF THE PERIOD OF THE PATRIOTIC WAR OF 1812

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    Monakhova E. N.

    2008-11-01

    Full Text Available This article compares the images from Alexander Pushkin's poem "Ruslan and Ludmila", collisions in the plot and certain episodes with historical events and particular historical persons modern to Pushkin.

  2. "SO YOU ARE RIGHT, THE ORACLE OF FRANCE...": ALEXANDER PUSHKIN'S POEM "RUSLAN AND LUDMILA" WITHIN THE FRAMEWORK OF RUSSIAN HISTORY OF THE PERIOD OF THE PATRIOTIC WAR OF 1812

    OpenAIRE

    Monakhova E. N.

    2008-01-01

    This article compares the images from Alexander Pushkin's poem "Ruslan and Ludmila", collisions in the plot and certain episodes with historical events and particular historical persons modern to Pushkin.

  3. Rune Frederiksen, Elizabeth R. Gebhard & Alexander Sokolicek (eds.), The Architecture of the Ancient Greek Theatre, Monographs of the Danish Institute, Volume 17 (Aarhus: Aarhus University Press and The Danish Institute at Athens, 2015)

    OpenAIRE

    Miller, William C.

    2017-01-01

    A review of the book: Rune Frederiksen, Elizabeth R. Gebhard & Alexander Sokolicek (eds.), The Architecture of the Ancient Greek Theatre, Monographs of the Danish Institute, Volume 17 (Aarhus: Aarhus University Press and The Danish Institute at Athens, 2015)

  4. A cultura é autônoma ou serve às elites? Um olhar sobre as abordagens sociológicas de Jeffrey Alexander e Pierre Bourdieu

    Directory of Open Access Journals (Sweden)

    Arthur Coelho Bezerra

    2011-06-01

    Full Text Available A proposta deste artigo é analisar comparativamente as abordagens sociológicas de Pierre Bourdieu e Jeffrey Alexander, no campo da cultura, com destaque para a crítica de Alexander ao programa de Bourdieu. Considera-se que a contraposição das ideias desses dois autores pode ser bastante útil para representar duas correntes distintas presentes nas ciências sociais: de um lado, aquela que enxerga uma submissão dos bens e das práticas culturais aos interesses das classes economicamente favorecidas; do outro, a que proclama a autonomia da cultura, cuja dimensão não poderia ser reduzida à estrutura social externa.

  5. „Warum ich nicht Diorit-Trachyt sagen soll.“ – Ein geologischer Brief Gustav Roses an Alexander von Humboldt

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    Konstantin Treuber

    2014-08-01

    Full Text Available Zusammenfassung Gustav Rose (1798-1873 begleitete Alexander von Humboldt auf seiner Russlandreise und stand bis zu Humboldts Tod persönlich und postalisch zum ihm in Kontakt. Die Edition des vorliegenden Briefs zielt darauf ab, die Bedeutung der Person Gustav Rose in ihrer Beziehung zu Alexander von Humboldt und ihrem Einfluss auf den mineralogisch-geologischen Teil des Kosmos zu beleuchten und dem Leser dieses interessante historische Dokument zugänglich zu machen. Abstract Gustav Rose (1798-1873 accompanied Humboldt on his journey to Russia. He kept in touch with Humboldt after this expedition until Humboldt died in 1859. The edition of the letter at hand aims at highlighting Rose’s relation to Humboldt and how he influenced the geological and mineralogical part of the Kosmos. It shall also make this impressive historical document accessible to readers by providing illustrating annotations.

  6. Shakespeare à l’écran : Makibefo d’Alexander Abela, un exemple extrême d’appropriation culturelle Alexander Abela’s Makibefo: an Example of Radical Cultural Appropriation on Screen

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    Anne-Marie Costantini-Cornède

    2009-06-01

    Full Text Available Alexander Abela’s Makibefo (1999 shot in Madagascar and played by non-professional actors. The use of the Antandroy people or “an ancient tribe” who had never even seen a film before, is an example of cultural appropriation or a “transcultural” approach to the play, a complex process of rewriting which consists in a narrative and aesthetic remoulding of the play adapted. By transposing the play Macbeth to an unusual context, a poor fishermen’s village lost at the other end of the world, the filmmaker means to enhance its mythic and universal dimension. He resorts to various narrative and aesthetic strategies such as plot displacements, character suppressions or dialogue simplifications as well as ample and systematic use of cinematic rhetoric (camera movements, framing and angle shot effects or light contrasts, which helps create a filmic mode. The process is paradoxical, as it is not so much meant to deconstruct the play as to reconstruct its essential meaning in a novel, powerful and visionary way, thus offering an alternative reading of the play.

  7. F. C. La Harpe’s report on the education of the grand dukes Alexander and Konstantin during the year 1791

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    Andrei Andreev

    2017-12-01

    Full Text Available This publication puts into the scientific use an unknown previously report of Frederic-Cesar La Harpe, a Swiss mentor at the court of Catherine II, who described in detail an educational content relative to the grand dukes Alexander and Kontantin in the year 1791. The original of this report, addressed to the “gouverneur-en-chef” of the Catherine’s grandchildren, count Nicolas Saltykov, was written in French and is published here translated into Russian with some commentaries to the historical names in this text. This report has a direct link to the series of the similar documents, which were already known by historians and dedicated to the education of the elder grandsons of Catherine II; thus this publication fills a lacuna in the existing row of revealed sources on this problem. The text of the report can make us follow the characteristic features of the education process held under the La Harpe’s guidance. It draws attention the main pedagogical system of La Harpe, his principles of teaching, as well as his observations on the characters of the grand dukes, their and abilities and competencies. It shows the central role played be La Harpe in the whole education of the grand dukes Alexander and Constantin, besides that, the significance of this even report for 1791 lies in the fact, that it was the last year when La Harpe had a possibility to teach according to his own plan and yet not prevented by the disadvantages, appearing from 1792, which arose due to the preparation to the marriage of the grand duke Alexander and the beginning of realization of Catherine’s idea to proclaim Alexander as a future successor of the Russian throne.

  8. Familial adult-onset Alexander disease with a novel mutation (D78N) in the glial fibrillary acidic protein gene with unusual bilateral basal ganglia involvement.

    Science.gov (United States)

    Wada, Yuko; Yanagihara, Chie; Nishimura, Yo; Namekawa, Michito

    2013-08-15

    In this report, we describe the case of a new Japanese family (32 to 64 years old; 2 females and 1 male) affected by adult-onset Alexander disease. Clinically, one member (age at onset, 56 years old) developed cerebellar ataxia, another (age at onset, 55 years old) showed cerebellar ataxia and pseudobulbar signs, and one member (32 years old) was asymptomatic. Marked atrophy of the medulla oblongata and spinal cord was detected in the two symptomatic patients by magnetic resonance imaging (MRI). However, in the asymptomatic patient, cervicomedullary atrophy was mild. Hyperintensity signals in the medulla oblongata were detected in the two symptomatic patients, but not in the asymptomatic patient. In addition, there are symmetrical hyperintensity signals in the posterior part of the globus pallidus on T2-weighted images in the two symptomatic patients, which are rarely observed in adult-onset Alexander disease. Molecular genetic analysis revealed a novel missense mutation (p. D78N) in the glial fibrillary acidic protein (GFAP) gene in this family. The typical atrophy of the medulla oblongata and upper cervical cord detected by MRI is the diagnostic feature of adult-onset Alexander disease. Genetic analysis of the GFAP gene is recommended for all patients with late-onset progressive ataxia and suspected of having adult-onset Alexander disease on the basis of MRI findings. Additionally, these characteristic MRI patterns might even lead to the identification of asymptomatic cases, as in one of our cases. Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.

  9. Alexander Disease: Report of Two Unrelated Infantile Form Cases, Identified by GFAP Mutation Analysis and Review of Literature; The First Report from Iran

    OpenAIRE

    Ashrafi, Mahmoud-Reza; Alireza TAVASOLI; Aryani, Omid; Alizadeh, Hooman; Houshmand, Massoud

    2013-01-01

    Background Alexander disease (AD) is a sporadic leukodystrophy that predominantly affects infants and children and usually results in death within ten years after onset. The infantile form comprises the most of affected individuals. It presents in the first two years of life, typically with progressive psychomotor retardation with loss of developmental milestones, megalencephaly and frontal bossing, seizures, pyramidal signs and ataxia. The diagnosis is based on magnetic resonance imaging (MR...

  10. Aberrant astrocyte Ca2+signals "AxCa signals" exacerbate pathological alterations in an Alexander disease model.

    Science.gov (United States)

    Saito, Kozo; Shigetomi, Eiji; Yasuda, Rei; Sato, Ryuichi; Nakano, Masakazu; Tashiro, Kei; Tanaka, Kenji F; Ikenaka, Kazuhiro; Mikoshiba, Katsuhiko; Mizuta, Ikuko; Yoshida, Tomokatsu; Nakagawa, Masanori; Mizuno, Toshiki; Koizumi, Schuichi

    2018-01-31

    Alexander disease (AxD) is a rare neurodegenerative disorder caused by gain of function mutations in the glial fibrillary acidic protein (GFAP) gene. Accumulation of GFAP proteins and formation of Rosenthal fibers (RFs) in astrocytes are hallmarks of AxD. However, malfunction of astrocytes in the AxD brain is poorly understood. Here, we show aberrant Ca 2+ responses in astrocytes as playing a causative role in AxD. Transcriptome analysis of astrocytes from a model of AxD showed age-dependent upregulation of GFAP, several markers for neurotoxic reactive astrocytes, and downregulation of Ca 2+ homeostasis molecules. In situ AxD model astrocytes produced aberrant extra-large Ca 2+ signals "AxCa signals", which increased with age, correlated with GFAP upregulation, and were dependent on stored Ca 2+ . Inhibition of AxCa signals by deletion of inositol 1,4,5-trisphosphate type 2 receptors (IP3R2) ameliorated AxD pathogenesis. Taken together, AxCa signals in the model astrocytes would contribute to AxD pathogenesis. © 2018 Wiley Periodicals, Inc.

  11. Growing community: the impact of the Stephanie Alexander Kitchen Garden Program on the social and learning environment in primary schools.

    Science.gov (United States)

    Block, Karen; Gibbs, Lisa; Staiger, Petra K; Gold, Lisa; Johnson, Britt; Macfarlane, Susie; Long, Caroline; Townsend, Mardie

    2012-08-01

    This article presents results from a mixed-method evaluation of a structured cooking and gardening program in Australian primary schools, focusing on program impacts on the social and learning environment of the school. In particular, we address the Stephanie Alexander Kitchen Garden Program objective of providing a pleasurable experience that has a positive impact on student engagement, social connections, and confidence within and beyond the school gates. Primary evidence for the research question came from qualitative data collected from students, parents, teachers, volunteers, school principals, and specialist staff through interviews, focus groups, and participant observations. This was supported by analyses of quantitative data on child quality of life, cooperative behaviors, teacher perceptions of the school environment, and school-level educational outcome and absenteeism data. Results showed that some of the program attributes valued most highly by study participants included increased student engagement and confidence, opportunities for experiential and integrated learning, teamwork, building social skills, and connections and links between schools and their communities. In this analysis, quantitative findings failed to support findings from the primary analysis. Limitations as well as benefits of a mixed-methods approach to evaluation of complex community interventions are discussed.

  12. ``The Waters I am Entering No One yet Has Crossed'': Alexander Friedman and the Origins of Modern Cosmology*

    Science.gov (United States)

    Belenkiy, A.

    2013-04-01

    Ninety years ago, in 1922, Alexander Friedman (1888-1925) demonstrated for the first time that the General Relativity equations admit non-static solutions and thus the Universe may expand, contract, collapse, and even be born. The fundamental equations he derived still provide the basis for the current cosmological theories of the Big Bang and the Accelerating Universe. Later, in 1924, he was the first to realize that General Relativity allows the Universe to be infinite. Friedman's ideas initially met strong resistance from Einstein, yet from 1931 he became their staunchest supporter. This essay connects Friedman's cosmological ideas with the 1998-2004 results of the astronomical observations that led to the 2011 Nobel Prize in Physics. It also describes Friedman's little known topological ideas of how to check General Relativity in practice and compares his contributions to those of Georges Lemaître. Recently discovered corpus of Friedman's writings in the Ehrenfest Archives at Leiden University sheds some new light on the circumstances surrounding his 1922 work and his relations with Paul Ehrenfest.

  13. Alexander von Humboldt: galvanism, animal electricity, and self-experimentation part 1: formative years, naturphilosophie, and galvanism.

    Science.gov (United States)

    Finger, Stanley; Piccolino, Marco; Stahnisch, Frank W

    2013-01-01

    During the 1790s, Alexander von Humboldt (1769-1859), who showed an early interest in many facets of natural philosophy and natural history, delved into the controversial subject of galvanism and animal electricity, hoping to shed light on the basic nature of the nerve force. He was motivated by his broad worldview, the experiments of Luigi Galvani, who favored animal electricity in more than a few specialized fishes, and the thinking of Alessandro Volta, who accepted specialized fish electricity but was not willing to generalize to other animals, thinking Galvani's frog experiments flawed by his use of metals. Differing from many German Naturphilosophen, who shunned "violent" experiments, the newest instruments, and detailed measurement, Humboldt conducted thousands of galvanic experiments on animals and animal parts, as well as many on his own body, some of which caused him great pain. He interpreted his results as supporting some but not all of the claims made by both Galvani and Volta. Notably, because of certain negative findings and phenomenological differences, he remained skeptical about the intrinsic animal force being qualitatively identical to true electricity. Hence, he referred to a "galvanic force," not animal electricity, in his letters and publications, a theoretical position he would abandon with Volta's help early in the new century.

  14. Political Storytelling on Instagram: Key Aspects of Alexander Van der Bellen’s Successful 2016 Presidential Election Campaign

    Directory of Open Access Journals (Sweden)

    Karin Liebhart

    2017-12-01

    Full Text Available This article addresses the strategic use of Instagram in election campaigns for the office of the Austrian Federal President in 2016. Based on a comprehensive visual analysis of 504 Instagram posts from Green-backed but independent presidential candidate Alexander Van der Bellen, who resulted as winner after almost one year of campaigning, this contribution reconstructs key aspects of digital storytelling on Instagram. By identifying relevant image types central to the self-representation of the candidate, this article shows how a politician makes use of a digital platform in order to project and manage desired images. The salience of image types allows for the reconstruction of underlying visual strategies: (1 the highlighting of the candidate’s biography (biographical strategy, (2 the presentation of his campaign team (team strategy, and (3 the presentation of the candidate as a legitimate office holder (incumbent strategy. The article thus sheds light on visual aspects of digital storytelling as relevant factor of political communication.

  15. Alexander Technique Training Coupled With an Integrative Model of Behavioral Prediction in Teachers With Low Back Pain.

    Science.gov (United States)

    Kamalikhah, Tahereh; Morowatisharifabad, Mohammad Ali; Rezaei-Moghaddam, Farid; Ghasemi, Mohammad; Gholami-Fesharaki, Mohammad; Goklani, Salma

    2016-09-01

    Individuals suffering from chronic low back pain (CLBP) experience major physical, social, and occupational disruptions. Strong evidence confirms the effectiveness of Alexander technique (AT) training for CLBP. The present study applied an integrative model (IM) of behavioral prediction for improvement of AT training. This was a quasi-experimental study of female teachers with nonspecific LBP in southern Tehran in 2014. Group A contained 42 subjects and group B had 35 subjects. In group A, AT lessons were designed based on IM constructs, while in group B, AT lessons only were taught. The validity and reliability of the AT questionnaire were confirmed using content validity (CVR 0.91, CVI 0.96) and Cronbach's α (0.80). The IM constructs of both groups were measured after the completion of training. Statistical analysis used independent and paired samples t-tests and the univariate generalized linear model (GLM). Significant differences were recorded before and after intervention (P < 0.001) for the model constructs of intention, perceived risk, direct attitude, behavioral beliefs, and knowledge in both groups. Direct attitude and behavioral beliefs in group A were higher than in group B after the intervention (P < 0.03). The educational framework provided by IM for AT training improved attitude and behavioral beliefs that can facilitate the adoption of AT behavior and decreased CLBP.

  16. Prolonged weight-shift and altered spinal coordination during sit-to-stand in practitioners of the Alexander Technique.

    Science.gov (United States)

    Cacciatore, Timothy W; Gurfinkel, Victor S; Horak, Fay B; Day, Brian L

    2011-10-01

    The Alexander Technique (AT) is used to improve postural and movement coordination and has been reported to be clinically beneficial, however its effect on movement coordination is not well-characterized. In this study we examined the sit-to-stand (STS) movement by comparing coordination (phasing, weight-shift and spinal movement) between AT teachers (n=15) and matched control subjects (n=14). We found AT teachers had a longer weight-shift (p<0.001) and shorter momentum transfer phase (p=0.01), than control subjects. AT teachers also increased vertical foot force monotonically, rather than unweighting the feet prior to seat-off, suggesting they generate less forward momentum with hip flexors. The prolonged weight-shift of AT teachers occurred over a greater range of trunk inclination, such that their weight shifted continuously onto the feet while bringing the body mass forward. Finally, AT teachers had greatly reduced spinal bending during STS (cervical, p<0.001; thoracic, p<0.001; lumbar, p<0.05). We hypothesize that the low hip joint stiffness and adaptive axial postural tone previously reported in AT teachers underlies this novel "continuous" STS strategy by facilitating eccentric contractions during weight-shift. Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.

  17. THE TRADITIONS OF ERMOLAY-ERAZMUS'S "THE TALE OF PETER AND FEVRONIA" IN ALEXANDER PUSHKIN'S NOVEL "THE CAPTAIN'S DAUGHTER"

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    Natalya Gennadievna Komar

    2013-11-01

    Full Text Available This article raises the question of the Old Russian sources of Alexander Pushkin’s novel The Captain’s Daughter and presents an attempt to identify the traditions of Ermolay-Erazmus’s The Tale of Peter and Fevronia in it. The main purpose of the research was to identify the parallelism between Pushkin’s novel and The Tale at the imaginative, narrative and thematic levels. Therefore, it was based on application of the comparative method. The main characters of both the books are compared in succession: Prince Peter and Peter Grinyov first, and then Fevronia and Masha Mironova. The results of the analysis lead to the conclusion that the male images reflect the spiritual evolution from being self-willed to obtaining Christian humility, and the key moment of the characters’ spiritual evolution is the meeting with wise virgins, etc. As far as the female images are concerned, the key parallel between them is the praise of their wisdom at the end of both stories. Thus, the material of the research enables us to speak about the traditions of The Tale of Peter and Fevronia being preserved in Pushkin’s last novel.

  18. Two Exceptional Witnesses of Latin American Independence: The Prussian Explorer Alexander Von Humboldt and The Virginian Politician Thomas Jefferson

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    Sandra Rebok

    2014-01-01

    Full Text Available Este artículo analiza las respectivas posturas de Alexander von Humboldt y Thomas Jefferson en relación con la independencia de los territorios hispanoamericanos y el modo en que estas se hallaban condicionadas por sus propias experiencias: Humboldt, como observador de la situación americana justo antes del comienzo de los movimientos independentistas; y Jefferson, como actor importante en la independencia de los EE.UU. y la posterior creación de una nueva sociedad. Asimismo, no se pueden estudiar sus respectivas posiciones hacia los movimientos independentistas en la América española, desvinculadas de sus conclusiones respecto a la Revolución francesa y sus consecuencias. El trabajo muestra de qué manera los dos personajes comentaron estos sucesos en la correspondencia que mantuvieron entre sí. Finalmente, también se evalúan, a través de estos famosos representantes del llamado Nuevo Mundo y el Viejo Mundo, las diferencias y similitudes en la manera de reaccionar ante estos eventos políticos y sociales desde el punto de vista europeo, en comparación con la mirada desde Norteamérica.

  19. Identification of a novel nonsense mutation in the rod domain of GFAP that is associated with Alexander disease.

    Science.gov (United States)

    Nam, Tai-Seung; Kim, Jin Hee; Chang, Chi-Hsuan; Yoon, Woong; Jung, Yoon Seok; Kang, Sa-Yoon; Shin, Boo Ahn; Perng, Ming-Der; Choi, Seok-Yong; Kim, Myeong-Kyu

    2015-01-01

    Alexander disease (AxD) is an astrogliopathy that primarily affects the white matter of the central nervous system (CNS). AxD is caused by mutations in a gene encoding GFAP (glial fibrillary acidic protein). The GFAP mutations in AxD have been reported to act in a gain-of-function manner partly because the identified mutations generate practically full-length GFAP. We found a novel nonsense mutation (c.1000 G>T, p.(Glu312Ter); also termed p.(E312*)) within a rod domain of GFAP in a 67-year-old Korean man with a history of memory impairment and leukoencephalopathy. This mutation, GFAP p.(E312*), removes part of the 2B rod domain and the whole tail domain from the GFAP. We characterized GFAP p.(E312*) using western blotting, in vitro assembly and sedimentation assay, and transient transfection of human adrenal cortex carcinoma SW13 (Vim(+)) cells with plasmids encoding GFAP p.(E312*). The GFAP p.(E312*) protein, either alone or in combination with wild-type GFAP, elicited self-aggregation. In addition, the assembled GFAP p.(E312*) aggregated into paracrystal-like structures, and GFAP p.(E312*) elicited more GFAP aggregation than wild-type GFAP in the human adrenal cortex carcinoma SW13 (Vim(+)) cells. Our findings are the first report, to the best of our knowledge, on this novel nonsense mutation of GFAP that is associated with AxD and paracrystal formation.

  20. Alexander von Humboldt: galvanism, animal electricity, and self-experimentation part 2: the electric eel, animal electricity, and later years.

    Science.gov (United States)

    Finger, Stanley; Piccolino, Marco; Stahnisch, Frank W

    2013-01-01

    After extensive experimentation during the 1790s, Alexander von Humboldt remained skeptical about "animal electricity" (and metallic electricity), writing instead about an ill-defined galvanic force. With his worldview and wishing to learn more, he studied electric eels in South America just as the new century began, again using his body as a scientific instrument in many of his experiments. As had been the case in the past and for many of the same reasons, some of his findings with the electric eel (and soon after, Italian torpedoes) seemed to argue against biological electricity. But he no longer used galvanic terminology when describing his electric fish experiments. The fact that he now wrote about animal electricity rather than a different "galvanic" force owed much to Alessandro Volta, who had come forth with his "pile" (battery) for multipling the physical and perceptable effects of otherwise weak electricity in 1800, while Humboldt was deep in South America. Humboldt probably read about and saw voltaic batteries in the United States in 1804, but the time he spent with Volta in 1805 was probably more significant in his conversion from a galvanic to an electrical framework for understanding nerve and muscle physiology. Although he did not continue his animal electricity research program after this time, Humboldt retained his worldview of a unified nature and continued to believe in intrinsic animal electricity. He also served as a patron to some of the most important figures in the new field of electrophysiology (e.g., Hermann Helmholtz and Emil du Bois-Reymond), helping to take the research that he had participated in to the next level.

  1. Geosciences Information for Teachers (GIFT) Workshops held in Conjunction with Alexander von Humboldt (AvH) EGU Conferences

    Science.gov (United States)

    Laj, Carlo; Cifelli, Francesca

    2015-04-01

    The Alexander von Humboldt Conference Series of the European Geosciences Union are a series of meetings held outside of Europe, in particular in South America, Africa or Asia, on selected topics of geosciences with a socio-economic impact for regions on these continents, jointly organised with the scientists and their institutes and the institutions of these regions. Given the increasing success of the GIFT workshops held in conjunction with the General Assemblies, since 2010 EGU has also developed a series of GIFT workshops held in conjunction with AvH conferences. Associated GIFT workshops were held in Merida, Yucatan, on the theme of Climate Change, Natural Hazards and Societies (March 2010), then in Penang, Malaysia (June 2011) on the theme of Ocean Acidification, in November 2012 in Cusco (Peru) on the theme of Natural Disasters, Global Change and the Preservation of World Heritage Sites, finally in Istanbul (March 2014) on "High Impact Natural Hazards Related to the Euro-Mediterranean Region. The next GIFT workshop is already planned for October 2015 in Adis Ababa (Ethiopia) on the theme "Water". In each case, the GIFT workshop was held on the last two days of the AvH conference and reunited 40-45 teachers from the nation where the AvH was held. Keynote speakers from AvH were speakers to the GIFT workshops which also included hands-on activities animated by sciences educators. These GIFT workshops represented the first workshops specifically aimed at teachers held in the country, and therefore represents a significant Earth Sciences contribution to secondary education in non European countries.

  2. Ice-dammed lateral lake and epishelf lake insights into Holocene dynamics of Marguerite Trough Ice Stream and George VI Ice Shelf, Alexander Island, Antarctic Peninsula

    Science.gov (United States)

    Davies, Bethan J.; Hambrey, Michael J.; Glasser, Neil F.; Holt, Tom; Rodés, Angél; Smellie, John L.; Carrivick, Jonathan L.; Blockley, Simon P. E.

    2017-12-01

    We present new data regarding the past dynamics of Marguerite Trough Ice Stream, George VI Ice Shelf and valley glaciers from Ablation Point Massif on Alexander Island, Antarctic Peninsula. This ice-free oasis preserves a geological record of ice stream lateral moraines, ice-dammed lakes, ice-shelf moraines and valley glacier moraines, which we dated using cosmogenic nuclide ages. We provide one of the first detailed sediment-landform assemblage descriptions of epishelf lake shorelines. Marguerite Trough Ice Stream imprinted lateral moraines against eastern Alexander Island at 120 m at Ablation Point Massif. During deglaciation, lateral lakes formed in the Ablation and Moutonnée valleys, dammed against the ice stream in George VI Sound. Exposure ages from boulders on these shorelines yielded ages of 13.9 to 9.7 ka. Following recession of the ice stream, George VI Ice Shelf formed in George VI Sound. An epishelf lake formed at 15-20 m asl in Ablation and Moutonnée valleys, dated from 9.4 to 4.6 ka, suggesting that the lake was stable and persistent for some 5000 years. Lake-level lowering occurred after this, with the lake level at 12 m at 3.1 ± 0.4 ka and at 5 m asl today. A readvance of the valley glaciers on Alexander Island at 4.4 ± 0.7 ka is recorded by valley glacier moraines overlying epishelf lake sediments. We speculate that the glacier readvance, which occurred during a period of warmth, may have been caused by a dynamic response of the glaciers to a lowering in surface elevation of George VI Ice Shelf.

  3. Una propuesta de la integración psicocorporal a través de la técnica Alexander y la danza movimiento terapia

    OpenAIRE

    Martínez Martínez, Laura

    2012-01-01

    Este trabajo es una propuesta de integración de la Técnica Alexander y la Danza Movimiento Terapia. Partiendo de la realidad de que ambas técnicas tienen como objetivo final la integración de la dimensión de la psique, del cuerpo y de la emoción, para restaurar el equilibrio integral del ser humano que como consecuencia aporta un estado de salud al individuo. Cada una de ellas se posiciona sobre un camino diferente hacia la curación, aunque comparten muchas bases en común. Una de ellas trata ...

  4. Entre a batuta e o tubo de ensaio: a carreira admirável de Alexandre Borodin Between baton and test tube: the admirable career of Alexander Borodin

    Directory of Open Access Journals (Sweden)

    Carlos A. L. Filgueiras

    2002-11-01

    Full Text Available Alexander Borodin (1833-1887 is a singularity in the history of science. Whereas other scientists may have kept lifelong interests in some artistic field, he was unique in pursuing with great success two parallel careers in both chemistry and music, managing to excell in both to the end of his life. Although he considered himself primarily a chemist, present-day appreciation of his powerful music has greatly surpassed interest for his chemistry. This article treats the life and the unusual double career of the Russian chemist-musician.

  5. Alexander Technique Lessons, Acupuncture Sessions or usual care for patients with chronic neck pain (ATLAS): study protocol for a randomised controlled trial.

    Science.gov (United States)

    MacPherson, Hugh; Tilbrook, Helen E; Richmond, Stewart J; Atkin, Karl; Ballard, Kathleen; Bland, Martin; Eldred, Janet; Essex, Holly N; Hopton, Ann; Lansdown, Harriet; Muhammad, Usman; Parrott, Steve; Torgerson, David; Wenham, Aniela; Woodman, Julia; Watt, Ian

    2013-07-10

    Chronic neck pain is a common condition in the adult population. More research is needed to evaluate interventions aiming to facilitate beneficial long-term change. We propose to evaluate the effect of Alexander Technique lessons and acupuncture in a rigorously conducted pragmatic trial with an embedded qualitative study. We will recruit 500 patients who have been diagnosed with neck pain in primary care, who have continued to experience neck pain for at least three months with 28% minimum cut-off score on the Northwick Park Neck Pain Questionnaire (NPQ). We will exclude patients with serious underlying pathology, prior cervical spine surgery, history of psychosis, rheumatoid arthritis, ankylosing spondylitis, osteoporosis, haemophilia, cancer, HIV or hepatitis, or with alcohol or drug dependency currently or in the last 12 months, or actively pursuing compensation or with pending litigation.The York Trials Unit will randomly allocate participants using a secure computer-based system. We will use block randomisation with allocation to each intervention arm being unambiguously concealed from anyone who might subvert the randomisation process.Participants will be randomised in equal proportions to Alexander Technique lessons, acupuncture or usual care alone. Twenty 30-minute Alexander Technique lessons will be provided by teachers registered with the Society of Teachers of the Alexander Technique and twelve 50-minute sessions of acupuncture will be provided by acupuncturists registered with the British Acupuncture Council. All participants will continue to receive usual GP care.The primary outcome will be the NPQ at 12 months, with the secondary time point at 6 months, and an area-under-curve analysis will include 3, 6 and 12 month time-points. Adverse events will be documented. Potential intervention effect modifiers and mediators to be explored include: self-efficacy, stress management, and the incorporation of practitioner advice about self-care and lifestyle

  6. How our changing research arena can inspire innovative environmental research in developing countries (Alexander von Humboldt Medal Lecture)

    Science.gov (United States)

    Bouma, Johan

    2017-04-01

    Alexander von Humboldt was a true pioneer by engagingly articulating an ecosystem-wide vision on environmental issues and research, connecting and moving beyond disciplinary boundaries. Focusing here on soil science as an important discipline within the geosciences, the work of our group has acted in the spirit of this approach by focusing on interdisciplinary systems research in different developing countries in close interaction with stakeholders, based on soil processes in a dynamic landscape context. But recent developments of internet and social media are drastically changing relations between science and society all over the world. Scientists have to continuously struggle to keep their "societal license to research". Researchers in so-called developed countries would be well advised to communicate lessons learned to scientists in developing countries allowing them to leapfrog and avoid making time- consuming mistakes adhering to yesterday's practices. Specifically, attention should be paid to: (i) more continuing interaction with stakeholders when planning and executing research. This takes time that should be allocated in research projects. ; (ii) the quality of a limited number of key papers rather than on the total number of published and cited scientific papers, when judging researchers; (iii) defining new research on the basis of proven inadequacy of existing techniques and methods, realizing that "new" is not necessarily "better" and that available research methods and procedures can solve many current environmental problems; (iv) showing the value of the scientific approach that does not articulate: "yet another opinion" but is essential to face the major environmental challenges of the 21th century. (v) demonstrate the crucial importance of interdisciplinary ecosystem research and innovation when addressing the seventeen UN Sustainable Developments Goals (SDG's) that are attractive now as a focus for the scientific effort in land-related research. (vi

  7. O Impacto da Técnica de Alexander na prática do canto: um estudo qualitativo sobre as percepções de cantores com experiência nessa interação

    OpenAIRE

    Paulo Henrique Campos Silva

    2007-01-01

    Este estudo investiga os possíveis benefícios da Técnica Alexander no desenvolvimento do cantor. A revisão de literatura adotada inclui a descrição anatomofisiológica dos órgãos e mecanismos do aparelho fonador, assim como os princípios e fundamentação teórica da Técnica Alexander e suas relações com o canto. Com o objetivo de obter informação sobre as interfaces entre as duas áreas, foram conduzidas entrevistas semi-estruturadas com cinco cantores praticantes da Técnica Alexander. Os dado...

  8. Beneficial effects of curcumin on GFAP filament organization and down-regulation of GFAP expression in an in vitro model of Alexander disease.

    Science.gov (United States)

    Bachetti, Tiziana; Di Zanni, Eleonora; Balbi, Pietro; Ravazzolo, Roberto; Sechi, GianPietro; Ceccherini, Isabella

    2012-09-10

    Heterozygous mutations of the GFAP gene are responsible for Alexander disease, a neurodegenerative disorder characterized by intracytoplasmic Rosenthal fibers (RFs) in dystrophic astrocytes. In vivo and in vitro models have shown co-localization of mutant GFAP proteins with the small heat shock proteins (sHSPs) HSP27 and alphaB-crystallin, ubiquitin and proteasome components. Results reported by several recent studies agree on ascribing an altered cytoskeletal pattern to mutant GFAP proteins, an effect which induces mutant proteins accumulation, leading to impaired proteasome function and autophagy induction. On the basis of the protective role shown by both these small heat shock proteins (sHSPs), and on the already well established neuroprotective effects of curcumin in several diseases, we have investigated the effects of this compound in an in vitro model of Alexander disease, consisting in U251-MG astrocytoma cells transiently transfected with a construct encoding for GFAP carrying the p.R239C mutation in frame with the reporter green fluorescent protein (GFP). In particular, depending on the dose used, we have observed that curcumin is able to induce both HSP27 and alphaB-crystallin, to reduce expression of both RNA and protein of endogenous GFAP, to induce autophagy and, finally, to rescue the filamentous organization of the GFAP mutant protein, thus suggesting a role of this spice in counteracting the pathogenic effects of GFAP mutations. Copyright © 2012 Elsevier Inc. All rights reserved.

  9. Steinpatrizen aus dem alten Kolumbien zur Vorbereitung des Gusses von Goldobjekten in verlorener Form Alexander von Humboldts „Kalendersteine“ der Muisca

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    Ursula Thiemer-Sachse

    2013-04-01

    Full Text Available Zusammenfassung Im vorspanischen Zentralkolumbien, vor allem in der Muisca-Kultur, wurden Hochreliefs auf Steinpatrizen zur Abformung von Wachsmatrizen für den Guss in verlorener Form benutzt, die Alexander von Humboldt irrtümlich für „Kalendersteine“ der Muisca hielt. Der wissenschaftsgeschichtliche Überblick beschäftigt sich mit den Ursachen dieses Irrtums und dessen Überwindung. Resumen En la región central de la Colombia prehispánica, especialmente en la cultura muisca, se utilizaron altos relieves en pátrices de piedra para moldear mátrices de cera para la fundición en cera perdida, erroneamente comprendidos por Alejandro de Humboldt como piedras de un “calendario” muisca. El conjunto de la historia de la ciencia trata de las causas y de la abnegación de esa idea. Abstract In pre-Hispanic central Colombia, especially in the region of the Muiscan culture, there were high reliefs on stone patrixes used for molding stencils (matrixes to found metals with the lost wax casting method. Alexander von Humboldt understood them as “calendar stones” of the Muisca. A survey of the history of science considers the reasons for and the surmounting of this erroneous idea.

  10. Alexander von Humboldt und Carlos Montúfar als Reisegefährten: ein Vergleich ihrer Tagebücher zum Chimborazo-Aufstieg

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    Reinhard Andress

    2011-03-01

    Full Text Available ZusammenfassungAls Alexander von Humboldt im Juni 1802 von Quito aus zum Rest seiner lateinamerikanischen Forschungsreise aufbrach, begleitete ihn, abgesehen von Aimé Bonpland, Carlos Montúfar bis nach Europa zurück begleitet, u.a. auch auf beim Versuch, den Chimborazo zu ersteigen. Bis kurz vor der Stadt Cajamarca im heutigen Peru schrieb Montúfar ein relativ unbekanntes Tagebuch zur Reise. Nach einem kurzen Ausflug in das Leben von Humboldts Begleiter steht im Zentrum der weiteren Ausführungen die Frage, ob sein Tagebuch ein anderes Licht auf Humboldt und speziell auf den Aufstiegsversuch wirft. Das läuft auf einen Vergleich der Tagebücher der beiden Reisegefährten hinaus und auf den Versuch, die scheinbaren Widersprüche aufzulösen.AbstractWhen Alexander von Humboldt left Quito in June 1802 in order to undertake the rest of his Latin-American trip of exploration, he was accompanied, aside from Aimé Bonpland, by Carlos Montúfar all the way back to Europe, including the attempt to scale the Chimborazo. Up to shortly before the city of Cajamarca in today’s Peru, Montúfar wrote an relatively unknown diary account of their travels. After a brief excursion into the life of Humboldt’s companion, the question is considered whether his diary sheds a different light on Humboldt and specifically on the mountain climb. That amounts to a comparison of the diaries of the two travel companions and to an attempt to explain the apparent contradictions.ResumenCuando Alexander von Humboldt salió de Quito en junio de 1802 para continuar con el resto de su viaje de exploración por la América Latina, fue acompañado por Carlos Montúfar además de Aimé Bonpland hasta que volvieron a Europa. Este trayecto incluía la tentativa de llegar a la cima del Chimborazo. Hasta un poco antes de la cuidad de Cajamarca que está en el Perú de hoy día, Montúfar mantenía un diario relativamente no conocido del viaje. Después de una breve excursión por

  11. On the Sources for the “Life of Alexander of Svir”: The Chapter “About the Person Who Wrote the Life of the Saint”

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    Natalia V. Pak

    2017-08-01

    Full Text Available The article analyzes the literary sources of the “Life of Alexander of Svir,” which was written by Hegumen Herodion of Svir. The discovery of new sources significantly expands the methodological possibilities of studying this literary monument. Knowing which text the medieval author reworked, we can reveal and describe those changes which were made by the author in the adaptation of the borrowed texts. In addition, knowing which circle of sources the author borrowed from, we can come to a conclusion concerning the result that the author sought. The study shows that the final chapter, with autobiographical information on the hagiographer’s life, was compiled on the basis of three sources: “The Life of Theodosius of Kiev,” “The Life of Nikon of Radonezh,” and the epilogue of scribe Athanasius to “Oko tserkovnoe.” The first of these sources was pointed out by I. Yakhontov (1881, but the borrowings from this source that are found in the final chapter of “The Life of Alexander of Svir” have still not been studied. The other two sources are revealed for the first time. Yakhontov concluded that Herodion used in his work the lives of Russian venerables and monastery founders, mainly the works of Pachomius the Serb. Now we have reason to believe that Alexander of Svir’s hagiographer was not ruled only by patriotic or genre considerations, and that he was not an imitator of Pachomius. As far as we can tell, the choice of the source was motivated by a specific literary purpose and by each separate episode, the description of which he created on the basis of the texts of his predecessors. (The examination of these motives, however, are beyond the scope of this article. The texts of all of the sources known to date (especially those sources which were unchanged when they were included in the “Life” of the saint can be used as a control element in the comparison of the copies of the literary monument and in the construction of a

  12. Rune Frederiksen, Elizabeth R. Gebhard & Alexander Sokolicek (eds., The Architecture of the Ancient Greek Theatre, Monographs of the Danish Institute, Volume 17 (Aarhus: Aarhus University Press and The Danish Institute at Athens, 2015

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    William C. Miller

    2017-03-01

    Full Text Available A review of the book: Rune Frederiksen, Elizabeth R. Gebhard & Alexander Sokolicek (eds., The Architecture of the Ancient Greek Theatre, Monographs of the Danish Institute, Volume 17 (Aarhus: Aarhus University Press and The Danish Institute at Athens, 2015

  13. Lamellar-in-lamellar self-assembled C-b-(B-b-A)(m)-b-B-b-C multiblock copolymers : Alexander-de Gennes approach and dissipative particle dynamics simulations

    NARCIS (Netherlands)

    Klymko, Tetyana; Markov, Vladimir; Subbotin, Andrei; ten Brinke, Gerrit

    2009-01-01

    A simple theoretical analysis of the lamellar-in-lamellar self-assembled state of ternary C-b-(B-b-A)(m)-b-B-b-C multiblock copolymer melts in the strong segregation limit is presented using the Alexander de Gennes approximation. For a given value of m, the influence of the chain length of the

  14. [Researchers training in the context of the collaborative projects: experiences of Instituto de Medicina Tropical "Alexander von Humbolt", Universidad Peruana Cayetano Heredia].

    Science.gov (United States)

    Gotuzzo, Eduardo; González, Elsa; Verdonck, Kristien

    2010-09-01

    Research is a main element for human and social development. Under this point of view, it involves particular challenges and opportunities for the so-called "developing countries". An approach for those challenges and opportunities comes from the analysis of two interrelated activities; the training of new researchers and the research development with institutions or researchers which are external to the institution ("collaborative research"). Both activities are essential for the consolidation, widening and updating of the institutional capabilities for scientific production. We present here the experiences of the Instituto de Medicina Tropical "Alexander von Humboldt" of the Universidad Peruana Cayetano Heredia, in relation to the training of new researchers, we discuss the four elements we consider key for this process; the promotion of stimulating environments for research, the proactive identification of fellows, the complementary advice and networks consolidation; and we analyze three successful models of international collaboration for the training of new researchers under different institutional approaches.

  15. Wâhkôhtowin: The Governance of Good Community–Academic Research Relationships to Improve the Health and Well-Being of Children in Alexander First Nation

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    Rebecca J. Gokiert

    2017-04-01

    Full Text Available Community-based participatory research (CBPR is a promising decolonizing approach to health and social sciences research with First Nation Peoples. In CBPR, the use of a community advisory committee can act as an anchoring site for trusting reciprocal relationships, collaborative decision-making, and co-learning and co-creation. Through a qualitative case study, this article illustrates the collective experiences of a well-established, multidisciplinary, and intersectoral committee that reviews, monitors, and guides multiple research projects in a First Nation community in Canada. Participants of the Alexander Research Committee (ARC share examples of the value of fostering a high level of commitment to building both positive working relationships and learning spaces that ultimately result in research and policy impacts for their community.

  16. Saint Sisoes above the grave of Alexander the Great. A monastic theme of post-Byzantine art and its examples from the 17th century Serbian painting

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    Živković Miloš

    2013-01-01

    Full Text Available The depiction of St. Sisoes above the grave of Alexander the Great was formulated at the end of the 15th century. The image in question is a visual interpretation of a short song («I see you, grave», and it was often painted in the churches throughout the Balkans during the next two centuries. With references to the textual basis of this iconographic theme, as well as its meaning, the article is devoted to insufficiently studied Serbian examples of frescoes of St. Sisoes above Alexander’s tomb, preserved on the walls of several churches painted in the first half of the 17th century. [Projekat Ministarstva nauke Republike Srbije, br. 177032: Tradicija, inovacija i identitet u vizantijskom svetu

  17. From Outer Space to the Circus Tent. Science Fiction and the Problems of ’68 in Alexander Kluge’s »Die Ungläubige«

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    Kirkland A. Fulk

    2013-11-01

    Full Text Available This paper explores Alexander Kluge’s forgotten work of science fiction Die Ungläubige , Kluge’s literary addendum to Die Artisten in der Zirkuskuppel: ratlos , and places it against the background of the aesthetic debates of 1968 and Kluge’s larger canon. Why did Kluge turn to science fiction at this particular time? How does this genre interrogate, expand on, or even challenge our understanding of Kluge and his aesthetic project, which in many ways cannot be thought apart from this pivotal period in German post-war history? Kluge’s text is at once a sharp critique of capitalist structures and a critical representation of utopian visions of the future, making the work an important piece of aesthetic, social and political commentary.

  18. Análisis de la traducción de la metáfora en el poema The Rape of the Lock de Alexander Pope

    OpenAIRE

    Vicente González, Bárbara

    2016-01-01

    El presente Trabajo de Fin de Máster trata sobre la traducción de las metáforas al español del poema The Rape of the Lock de Alexander Pope. Está dividido en tres bloques, dos bloques teóricos y un bloque práctico. En el primero de los bloques teóricos se abordan el contexto histórico-político y socio-cultural en el que se enmarcan tanto la obra como la vida del propio autor. En el segundo bloque teórico del trabajo se presentan las teorías de la traducción literaria, así como,...

  19. Russland ist seit jeher das gelobte Land für Magnetismus gewesen: Alexander von Humboldt, Carl Friedrich Gauß und die Erforschung des Erdmagnetismus in Russland

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    Elena Roussanova

    2011-03-01

    Full Text Available AbstractRussia covers an essential part of the earth’s surface. Hence it played an exceptional role in the scientific investigation of earthmagnetism during the 18th and even more in the 19th century. Through Alexander von Humboldt’s interest in earthmagnetism and his organizational and diplomatic abilities earthmagnetism became an international phenomenon studied at many research institutions. Unlike Humboldt, Carl Friedrich Gauss established a new scientific approach. Humboldt’s aim to globally investigate the physical earth and Gauss’ idea to centralize the measurements led to the foundation of a main physical observatory in St. Petersburg in 1849, which, at its time, was a completely new institution exclusively set up for the new discipline geophysics. The head of this institution became the Russian physicist Adolph Theodor Kupffer, collaborator and colleague as well of Humboldt and of Gauss.ZusammenfassungWegen seiner riesigen Ausdehnung hat Russland bei der wissenschaftlichen Erforschung des Erdmagnetismus bereits im 18. Jahrhundert und erst recht im 19. Jahrhundert eine herausragende Rolle gespielt. Alexander von Humboldts Engagement auf dem Gebiet des Erdmagnetismus, sein organisatorisches und diplomatisches Geschick verhalfen dazu, dass man sich international und vielerorts dem Phänomen des Erdmagnetismus zuwandte. Carl Friedrich Gauß stellte dessen Erforschung in der relativ kurzen Zeit zwischen 1833 und 1839 auf ein ganz neues wissenschaftliches Fundament. Die Pläne Humboldts, die Erde möglichst global physikalisch zu erforschen, und die Pläne von Gauß, die erdmagnetischen Forschungen zentral zu koordinieren, gipfelten 1849 in der Gründung des Physikalischen Hauptobservatoriums in St. Petersburg, das zu jener Zeit eine absolut neuartige Institution darstellte – es war der Erforschung der neuen Disziplin Geophysik gewidmet. An der Spitze dieser Institution stand der russische Physiker Adolph Theodor Kupffer

  20. Non-Euclidean Space, Movement and Astronomy in Modern Art: Alexander Calder’s Mobiles and Ben Nicholson’s Reliefs

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    Malloy Vanja

    2013-09-01

    Full Text Available John Keats once wrote that ‘there is no such thing as time and space’ rather, believing that time and space are mental constructs that are subject to a variety of forms and as diverse as the human mind. In the 1920s through the 1930s, modern physics in many ways supported this idea through the various philosophical writings on the Theory of General Relativity to the masses by scientists such as Arthur Eddington and Albert Einstein. These new concepts of modern physics fundamentally changed our understanding of time and space and had substantial philosophical implications, which were absorbed by modern artists resulting in the 1936 Dimensionist Manifesto. Seeking to internalize the developments of modern science within modern art, this manifesto was widely endorsed by the most prominent figures of the avant-garde such as Marcel Duchamp, Jean Arp, Naum Gabo, Joan Miró, László Moholy-Nagy, Wassily Kandinsky and Alexander Calder. Of particular interest to this manifesto was the new concept of the fourth-dimension, which in many ways revolutionized the arts. Importantly, its interpretation varied widely in the artistic community, ranging from a purely physical four-dimensional space, to a kinetic concept of space in which space and time are linked, to a metaphysical interest in a space that exists beyond the material realm. The impact of modern science and astronomy on avant-garde art is currently a bourgeoning area of research with considerable implications to our rethinking of substantial artistic figures of this era. Through a case study of Alexander Calder’s Mobiles and Ben Nicholson’s Reliefs, this paper explores how these artworks were informed by an interest in modern science.

  1. Participação das enfermeiras no processo de implantação de práticas obstétricas humanizadas na maternidade Alexander Fleming (1998-2004 Participación de las enfermeras en el proceso de implementación de prácticas de obstetricia humanizada en la maternidade Alexander Fleming (1998-2004 Participation of nurses in the process of implementation of obstetrical practices in the maternity humanized Alexander Fleming (1998-2004

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    Jane Márcia Progianti

    2012-09-01

    Full Text Available Estudo de natureza histórico-social cujo objetivo é analisar o processo de inserção das enfermeiras na assistência ao parto e as lutas dessas profissionais para implantar as práticas obstétricas humanizadas na Maternidade Alexander Fleming. Utilizou-se a história oral temática como método. As etapas da análise foram: ordenação, classificação e triangulação dos dados. Para sustentação da análise, utilizamos os conceitos de campo, habitus, poder simbólico e capital, de Pierre Bourdieu. Os resultados apontaram que a inserção das enfermeiras na assistência ao parto ocorreu mediante a lotação de recursos humanos para este projeto e de uma capacitação intensiva. Ao serem inseridas no centro obstétrico, as enfermeiras criaram um espaço próprio de atuação e elaboraram um protocolo assistencial. Concluímos que as estratégias de luta simbólica utilizadas pelas enfermeiras contribuíram para a conquista de espaços que as distinguiram no campo pelo desenvolvimento de práticas humanizadas que estavam de acordo com seu habitus.Se trata de un estudio de carácter histórico y social cuya finalidad es analizar el proceso de inserción de las enfermeras en el momento de la entrega y la lucha de estos profesionales para implementar las prácticas obstétricas humanizadas en la Maternidade Alexander Fleming. El método utilizado fue la historia oral temática. Los pasos del análisis fueron: ordenación, clasificación y triangulación de los datos. Para sustentación del análisis se utilizó los conceptos de campo, habitus, poder simbólico y capital, de Pierre Bourdieu. Los resultados mostraron que la inclusión de las enfermeras en la atención del parto se produjo a través de la capacidad de recursos humanos para este proyecto y de un entrenamiento intensivo. Al ser insertado en el centro obstétrico, las enfermeras han creado su propio espacio para la acción y han desarrollado un protocolo de atención. Concluimos que

  2. Scientific findings of Alexander von Humboldt's expedition into the Spanish-American Tropics (1799-1804 from a geographical point of view

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    Gerd Kohlhepp

    2005-06-01

    Full Text Available Alexander von Humboldt's expedition from 1799 till 1804 to the "equinoctial regions of the new world" led through Venezuela, Cuba, Colombia, Ecuador, Peru, and Mexico. In Europe an increased knowledge of the "New World" was connected with the privately funded journey, which served purely scientific purposes and had nothing to do with the exploration and exploitation of natural resources. Besides the research results, which were based on new measuring methods and the quantitative ascertainment of scientific basics, the journey also made possible detailed descriptions in matters of regional studies including social, socio-economic, political, and economic-geographic circumstances, which were based on empirical field studies. The expedition took place shortly before the political change in Latin America. Humboldt, who still experienced the feudal character of global economy based on slave labor in the colonies, vehemently criticized this economic structure - although he was a noble - and its unbearable social conditions. This is the reason why Humboldt is still admired in Latin America till this day. In Europe the scientific insights of his journey to the tropics and his innovative impulses in geog raphy as well as in many other disciplines brought him fame and lasting recognition as a universal scholar, who had crucial influence on the development of the sciences during the first half of the 19th century.A expedição científica de Alexander von Humboldt de 1799 a 1804 pela região equinocial do novo mundo foi realizada através dos países Venezuela, Cuba, Colômbia, Equador, Peru e México. Esta viagem, destinada à obtenção de novos conhecimentos aprofundados sobre o "novo mundo" para a Europa, foi financiada com meios particulares e tinha exclusivamente objetivos científicos e não a exploração de recursos naturais. Paralelamente aos resultados de pesquisa, fundamentados em novos métodos de medida e da elaboração quantitativa de

  3. Frontale Präsenz - Zu einem unbekannten Porträt Alexander von Humboldts im Besitz des französischen Conseil d’État

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    David Blankenstein

    2015-12-01

    Full Text Available Zusammenfassung Ein bislang unveröffentlichtes Porträt Alexander von Humboldts aus der Hand Frédéric d’Houdetots, ein Schüler des Malers Jacques-Louis David, bereichert die Humboldt-Ikonographie um eine Darstellung, die den berühmten Reisenden und Gelehrten als jungen Mann, wenige Jahre nach seiner Rückkehr aus Amerika zeigt – beeindruckend lebendig, fokussiert und präsent. Das 1807 während der Franzosenzeit in Berlin entstandene Porträt verweist als Teil eines im Conseil d’État in Paris aufbewahrten Porträt-Albums auf die Zirkel und Beziehungen, die sich in der besetzten preußischen Hauptstadt zwischen Besatzern, jüdischen Salonkreisen und der wissenschaftlichen Community gebildet haben, ein Nährboden für den transnationalen Austausch von Vertretern einer jungen und vitalen Generation, die sich als echte Europäer verstanden. Résumé Un portrait jusqu’à présent inédit d’Alexander von Humboldt par Frédéric d’Houdetot, élève de Jacques-Louis David, enrichit l’iconographie humboldtienne d’une effigie qui donne à voir le célèbre voyageur et érudit en jeune homme, quelques années seulement après son retour des Amériques – un portrait qui frappe par sa vitalité, sa concentration et la forte présence du savant. Dessiné dans le contexte de l’occupation de Berlin par l’armée napoléonienne et conservé au Conseil d’Etat à Paris, ce portrait est issu d’un album réunissant un grand nombre d’autres portraits de Berlinois des années 1800, qui témoigne des relations étroites que l’occupant put entretenir avec les représentants de l’élite juifs de la ville et la communauté scientifique, dans une dynamique propice aux échanges transnationaux d’une génération jeune, vitale et profondément européenne. Summary A previously unreleased portrait of Alexander von Humboldt, drawn by Jacques-Louis David’s disciple Frédéric d’Houdetot, adds a lively, focused and astonishingly present

  4. Transatlantic communication in the 19th century aspects of the correspondence between alexander von humboldt and george ticknor

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    Schwarz, Ingo

    2004-12-01

    Full Text Available The Prussian explorer Alexander von Humboldt (1769-1859 and the North American scholar George Ticknor (1791-1871 met in 1817 in Paris, after Ticknor had studied languages, history, and natural sciences at the University of Göttingen. Two years later, he became the first Harvard Professor of the French and Spanish Languages and Literatures. When Ticknor visited Europe in 1836 and 1856, Humboldt was his guide in the Prussian Capital. Both, Humboldt and Ticknor were mediators between the Old World and the New Continent at a time when nationalism was fashionable both in literature and in politics. Humboldt and Ticknor did not agree on all political questions. However, their respect for each other helped them avoid controversial topics in their correspondence, and possibly in their conversations. With their ability to rank the things they had in common higher than their differences they were able to maintain a fruitful transatlantic dialogue over forty years.

    El explorador prusiano Alexander von Humboldt (1769-1859 y el erudito norteamericano George Ticknor (1791-1871 se conocieron en 1817 en París, después que Ticknor había estudiado idiomas, historia y ciencias naturales en la Universidad de Göttingen. Dos años más tarde, llegó a ser el primer Profesor Harvard de Lenguas y Literatura francesa y española. Cuando Ticknor visitó Europa en 1836 y 1856, Humboldt fue su guía en la capital prusiana. Humboldt y Ticknor fueron mediadores entre el Viejo Mundo y el Nuevo Continente en una época en que el nacionalismo estaba de moda en la literatura y la política. Humboldt y Ticknor no estaban de acuerdo en todas las cuestiones políticas. Sin embargo, el respecto que existía entre ellos evitó los asuntos controvertibles en su conversación y posiblemente en su correspondencia. Con su habilidad para clasificar las cosas tenían en común por encima de sus diferencias ser capaces de mantener un diálogo fructífero trasatlántico durante

  5. A atualização do habitus da enfermeira obstétrica no processo de implantação do modelo humanizado na maternidade Alexander Fleming (1998-2004)

    OpenAIRE

    Aline Bastos Porfirio

    2011-01-01

    Trata-se de um estudo de natureza histórico-social cujo objeto é a atualização do habitus da enfermeira obstétrica durante o processo de implantação da assistência humanizada na maternidade Alexander Fleming, no período de 1998-2004. Os objetivos deste estudo são: descrever as circunstâncias da inserção das enfermeiras obstétricas na assistência ao parto humanizado na maternidade Alexander Fleming; analisar as estratégias de luta no processo de implantação das práticas humanizadas na maternid...

  6. War and religion: Lucian, the oracle of Alexander in Abonuteichos, and the military defeats of Sedatius Severianus against the Parthians, and Marcus Aurelius against Cuadi and Marcomanni

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    Sabino PEREA YÉBENES

    2013-03-01

    Full Text Available Taking as a start point the opuscule by Lucian of Samosata entitled Alexander or The false Prophet, we call attention on some autophone oracles sent by this controversial oracular shrine in Abonuteichos: with singular attention to oracle given to imperial legate Sedatius Severianus, in war against the parthians (Luc. Alex. 27, and the so called «oracle of the two lions» (Luc. Alex. 48, requested by the emperor Marcus Aurelius shortly before the beginning of the military campaign against the barbarians Cuadi and Marcomanni. The rising of divinatory practices and the popularization of «holy men» in this time are symptoms -rather than having relation with crisisof spiritual changes in the religious beliefs of the period. In the case studies analyzed here, these changes are also transferred to the political field: the war in the frontiers, which also show or announced far-reaching structural changes, with barbarian attacks becoming more systematic and effective who harassed the Roman power across the natural barrier of the Danube. We relate the «oracle of lions» with the scene XII (destroyed, but preserved in a drawing of the XVII Century of the Aurelian Column in Rome.

  7. A canine orthologue of the human GFAP c.716G>A (p.Arg239His) variant causes Alexander disease in a Labrador retriever.

    Science.gov (United States)

    Van Poucke, Mario; Martlé, Valentine; Van Brantegem, Leen; Ducatelle, Richard; Van Ham, Luc; Bhatti, Sofie; Peelman, Luc J

    2016-06-01

    Alexander disease (AxD) is a fatal neurodegenerative disorder of astrocyte dysfunction in man, for which already a number of causal variants are described, mostly de novo dominant missense variants in the glial fibrillary acidic protein (GFAP). A similar disorder was already phenotypically described in animals but without the identification of causal variants. We diagnosed a Labrador retriever with a juvenile form of AxD based on clinical (tetraparesis with spastic front limbs mimicking 'swimming puppy syndrome') and pathological (the detection of GFAP containing Rosenthal fibers in astrocytes) features. In order to identify a causal variant, the coding sequences of the four detected GFAP transcript variants (orthologues from human transcript variants α, γ, δ/ɛ and κ) were sequenced. From the five detected variants, a heterozygous c.719G>A nucleotide substitution resulting in a p.Arg240His substitution was considered to be causal, because it is orthologous to the heterozygous de novo dominant c.716G>A (p.Arg239His) hotspot variant in man, proven to cause a severe phenotype. In addition, the variant was not found in 50 unrelated healthy Labrador retrievers. Because the condition in dogs is morphologically similar to man, it could be a promising animal model for further elucidating the genotype/phenotype correlation in order to treat or prevent this disease.

  8. An autopsied case of adult-onset bulbospinalform Alexander disease with a novel S393R mutation in the GFAP gene.

    Science.gov (United States)

    Iwasaki, Yasushi; Saito, Yufuko; Mori, Keiko; Ito, Masumi; Mimuro, Maya; Aiba, Ikuko; Saito, Kozo; Mizuta, Ikuko; Yoshida, Tomokatsu; Nakagawa, Masanori; Yoshida, Mari

    2015-01-01

    A 50-year-old Japanese man with no apparent family history noticed diplopia. He gradually showed gait disturbance and dysuria. Abducens disorder of eye movement with nystagmus, tongue atrophy with fasciculation, spastic tetraparesis, and sensory disturbance were also observed. MRI showed severe atrophy of the medulla oblongata to the cervical cord ("tadpole appearance"). Tracheotomy and gastrostomy were performed 7 years after onset due to the development of bulbar palsy. Death occurred following respiratory failure after 11 years total disease duration. The brain weighed 1,380 g. The cerebrum, cerebellum, midbrain, and upper pons were preserved from atrophy, but the medulla oblongata to the cervical cord showed severe atrophy. A few Rosenthal fibers were observed in the cerebral white matter, basal ganglia, and cerebellum, whereas numerous Rosenthal fibers were observed in the medulla oblongata to the cervical cord. Myelin loss with relatively preserved axons was extensively observed from the middle of the pons to the spinal cord. The clinicopathological diagnosis was adult-onset bulbospinal-form Alexander disease. Glial fibrillary acidic protein (GFAP) gene analysis revealed a novel mutation of S393R. Expression patterns of S393R mutant GFAP using adrenal carcinoma-derived cells (SW13 cells) showed a decreased number of filamentous structures and abnormal aggregates.

  9. Guerra y pecados de un inglés en cádiz (1810-1812. Fragmentos de la autobiografía de Alexander Dallas

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    Fernando Durán López

    2016-07-01

    Full Text Available El escritor inglés Alexander Dallas participó en el ejército británico que operó en la Guerra de la Independencia y a su fin escribió varias obras literarias de tema español. Se ofrece aquí una traducción de parte de su autobiografía, publicada en 1871, que incluye los capítulos consagrados a su estancia en Cádiz y la Isla de León de 1810 a 1812. En esas páginas el autor refleja el ambiente de la vida social allí (las tertulias de la buena sociedad y evocaciones de las fiestas de Carnaval en 1812, detalles de la organización de la intendencia militar, así como episodios militares como la batalla de Chiclana, algunas operaciones de defensa ante el asedio francés, los efectos de los célebres bombardeos de larga distancia sobre el caso urbano, el júbilo popular cuando el sitio fue levantado y el estado en que quedaron tras la retirada francesa las poblaciones donde se habían asentado. Se relata también un viaje a Ceuta.

  10. “The Snob’s Chaldron”: Alexander Davison and the Private Patronage of History Painting in Early Nineteenth-Century Britain

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    Katherine

    2017-11-01

    Full Text Available In 1806, the wealthy merchant Alexander Davison commissioned eight leading artists to produce paintings depicting scenes from British history to hang in the dining room of his London townhouse in St James’s Square. Many of these pictures are now lost but a record of the gallery is preserved in the patron’s Descriptive Catalogue, which is presented here as a digital facsimile. Davison’s project represents a rare example of a private individual investing heavily in history painting at a time when the dearth of patronage for the genre in Britain preoccupied artists and critics, prompting widespread debate over who could and should support the production of historical pictures. This article explores Davison’s activities in the light of these concerns. It argues that the gallery was designed to serve an ambitious private agenda as the merchant–a prosperous parvenu and convicted fraudster–sought to secure entry into upper-class society and to escape the taint of scandal. Deploying a traditionally public genre for private gain, Davison’s project invites us to consider the opportunities, as well as the problems, associated with patronizing history painting in early nineteenth-century Britain.

  11. A film of patients with movement disorders made in Queen Square, London in the Mid-1920s by Samuel Alexander Kinnier Wilson.

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    Reynolds, E H; Healy, D G; Lees, A J

    2011-12-01

    Through Edward Reynolds' collaboration with Samuel Alexander Kinnier Wilson's (SAKW) son, James, on Babylonian neurology and psychiatry, and his contact with James' nephew, Jim, grandson of SAKW, a remarkable film of patients with movement disorders, made by SAKW in the mid-1920s, has come to light. The 20-min silent film with captions by SAKW includes patients with senile tremor, Parkinson's disease and postencephalitic parkinsonism, hemiballismus, Huntington's chorea, Sydenham's chorea, hysterical palsy and tremor, multiple sclerosis, and progressive lenticular degeneration. Most of the patients are filmed in the square outside the National Hospital. The British Film Institute dates the film to 1924 and the captions to 1925. The case records of 6 of the 14 patients, who were admitted to the National Hospital, Queen Square, under the care of Dr. SAKW have been identified and summarized. SAKW may have been stimulated and facilitated to make this film through his personal contact with Charlie Chaplin with whom he stayed at his Californian estate, probably in the summer of 1924. The first films of neurological patients were made in Europe and USA at the beginning of the 20th century, although most have perished. This may be one of the oldest examples from UK. It is also notable for the inclusion of Wilson's disease and a brief shot of SAKW himself. Copyright © 2011 Movement Disorder Society.

  12. Alexander Disease: Report of Two Unrelated Infantile Form Cases, Identified by GFAP Mutation Analysis and Review of Literature; The First Report from Iran.

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    Ashrafi, Mahmoud-Reza; Tavasoli, Alireza; Aryani, Omid; Alizadeh, Hooman; Houshmand, Massoud

    2013-08-01

    Alexander disease (AD) is a sporadic leukodystrophy that predominantly affects infants and children and usually results in death within ten years after onset. The infantile form comprises the most of affected individuals. It presents in the first two years of life, typically with progressive psychomotor retardation with loss of developmental milestones, megalencephaly and frontal bossing, seizures, pyramidal signs and ataxia. The diagnosis is based on magnetic resonance imaging (MRI) findings and confirmed by GFAP gene molecular testing. GFAP gene encodes glial fibrillary acidic protein, is the only gene in which mutation is currently known to cause AD which is inherited in autosomal dominant manner. In this article we report the first two Iranian cases of infantile AD and their clinical, brain MRI and molecular findings. We report two novel mutations too in the GFAP gene that are associated with infantile form of AD. GFAP gene mutations are a reliable marker for infantile AD diagnosed according to clinical and MRI defined criteria. A genotype-phenotype correlation had been discerned for the two most frequently reported GFAP gene mutations in infantile type of AD (R79 and R239), with the phenotype of the R79 mutations appearing much less severe than that of the R239 mutations. Our findings confirm this theory.

  13. Invariance of vestibulo-ocular reflex gain to head impulses in pitch at different initial eye-in-orbit elevations: implications for Alexander's law.

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    Anastasopoulos, Dimitri; Anagnostou, Evangelos

    2012-10-01

    These findings are in line with previous data on the horizontal vestibulo-ocular reflex (VOR) from this laboratory and suggest that eye position signals do not modulate natural vestibular responses. Hence, the Alexander's law (AL) phenomenon cannot be interpreted simply as a consequence of vestibular or oculomotor nuclei activity modulation with desired gaze. AL states that the intensity of the spontaneous nystagmus of a patient with a unilateral vestibular lesion grows with increasing gaze in the direction of the fast phase. Some of the mechanisms proposed to account for the gaze effects assume a direct modification of the normal VOR by eye position signals. We tested the validity of these assumptions and investigated the effects of gaze direction on the normal vertical human VOR in the behaviorally relevant high frequency range. Head and eye movements were recorded with the search coil method during passive head impulses in pitch, while subjects were asked to hold gaze at various elevation angles in 8° steps within ± 16° from the straight ahead reference position. Upward and downward head rotations produced VOR gains of similar magnitude. Furthermore, the gain remained unaffected by eye-in-orbit position for both upward and downward head impulses.

  14. Effect of the Alexander Technique on Muscle Activation, Movement Kinematics, and Performance Quality in Collegiate Violinists and Violists: A Pilot Feasibility Study.

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    Wolf, Rachelle C; Thurmer, Harvey P; Berg, William P; Cook, Henry E; Smart, L James

    2017-06-01

    Musicians are trained to attend to aural and visual senses, to the detriment of kinesthetic awareness, which often results in unnecessary muscle tension and narrowed attentional focus. The Alexander technique (AT) addresses these concerns by approaching action using a process of whole-body consciousness. Incorporation of AT concepts into skill practice may reduce static tension in playing and result in both prevention of injury and improved quality of performance, but objective evidence of these effects is lacking. This pilot feasibility study was designed to determine if muscle activation, movement kinematics, musical performance, and qualitative self-assessment over the course of a 10- week AT intervention are viable means to assess the efficacy of AT in violinists/ violists. Two groups of collegiate violinists and violists participated: Group A (n=4) participated in weekly 1-hour group AT lessons and kept a personal journal of their progress. Group B (n=3) received no AT lessons. Pre- and post tests included muscle activation recorded using electromyography (EMG) and movement kinematics recorded via motion tracking as musicians played a scale and a Kreutzer étude. Performance was also video-recorded and evaluated by an expert for quality and kinesthetic awareness. The results suggest that the measures and intervention employed could, with some adaptation, be a viable means of determining the potential benefits of AT training.

  15. Analysis of the main activities of the city center of Alexander's psychosomatic hospital of St. Petersburg, focused on the choice of priorities in perfection of treatment and prophylaxis

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    N. P. Vanchakova

    2014-01-01

    Full Text Available The authors have analyzed the results of the City Psychosomatic Centre (CPSC activity in 2009-2011 ys in order to find out the most important trends in the clinical work that may be helpful in planning of management and prophylaxis. The methods applied were statistical and clinico-statistical analyses of the results of of the Center work in 2009-2011 ys. There were changes in the structure by increasing the incidence of diseases associated with stress and organic damage brain with mental disorders, showed an increase in the flow of male patients. Found that the average length of stay in bed in the center of psychosomatic inpatient unit was 9.2-9.7 days, which creates barriers to good practice the use of antidepressants. Overcoming of these challenges can be achieved through the formation of new forms of continuity between the departments of the psychosomatic center, the health center and the offices of St. Petersburg SHCI «Alexander's Hospital,» and other medical institutions of the city.

  16. Generalized rainbows and unfolded glories of oblate drops: organization for multiple internal reflections and extension of cusps into Alexander's dark band.

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    Marston, P L; Kaduchak, G

    1994-07-20

    Oblate drops of water can produce caustics where, unlike a simple Airy caustic, more than two rays merge. We extend previous treatments of generalized primary rainbows based on catastrophe optics [Opt. Lett. 10, 588 (1985); Proc. R. Soc. (London) A 438, 397 (1992)] to rays having (p - 1) = 2 to 5 internal reflections. The analysis is for a horizontally illuminated ellipsoid with a vertical symmetry axis. Aspect ratios causing a vanishing of the vertical curvature at the equator for the outgoing wave front are found from generalized ray tracing. In response to infinitesimal deformation, the axial caustic of real glory rays unfolds producing cusps. Laboratory observations with laser illumination demonstrate that cusps resulting from rays with five internal reflections extend into Alexander's dark band when the drop's aspect ratio is near 1.08. The evolution of this p = 6 scattering pattern as cusps meet the quinary rainbow is suggestive of an E(6) catastrophe. For ellipsoids of varying aspect ratio and refractive index N, there is an organizing singularity associated with an exceptionally flat outgoing wave front from spheres with N = p.

  17. Repräsentation und Augenschein. Organisation des Wissens und Wahrnehmung des Fremden um 1800 am Beispiel der Reiseberichte und -tagebücher Alexander von Humboldts

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    Eva-Maria Siegel

    2003-10-01

    Full Text Available Article in German, Abstracts in English, German and FrenchIn modern times the instrumental reason is meant to be a condition for objectivity and rationality. Referring to this consideration the lecture turns to the question, in which way the instrumental reason impresses upon the encounter with the foreign around 1800 and on which organizational forms of knowledge it is based. How do the representations of European stores of knowledge shape that global reference framework, in which the travel reports and diaries of Alexander von Humboldt are today?The thesis is, that his recordings about the conquest of the New World place the relation of the European world of senses to the supposed directness of the appearance and to the world of senses in the center. Furthermore a comparison to the writings of Georg Forster shows, in which way a change of representational forms at the turn of the 18th to the 19th century, which goes far beyond the genre of travel reports, was introduced.

  18. Considerações sobre os conceitos de natureza, espaço e morfologia em Alexander von Humboldt e a gênese da geografia física moderna Considerations on the concepts of nature, space, and morphology in Alexander von Humboldt and on the genesis of modern physical geography

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    Antonio Carlos Vitte

    2010-01-01

    Full Text Available Discute a formação dos conceitos de natureza, espaço e morfologia na obra de Alexander von Humboldt e seus impactos na formação da geografia física moderna. Influenciado pelas reflexões de Kant em Crítica do juízo e pelos trabalhos de Goethe e Schelling, Humboldt desenvolveu nova interpretação e representação para a natureza na superfície da Terra, em que o conceito de espacialidade é fundamental para a explicação dos fenômenos da natureza. A geografia física moderna estrutura-se a partir de complexo cruzamento de influências estéticas e instrumentais desenvolvidas por Humboldt, nas quais o princípio da conexão é importante para a invenção artística e científica do conceito de paisagem geográfica.The article discusses how Alexander von Humboldt developed the concepts of nature, space, and morphology in his works and impacted the shaping of modern physical geography. Influenced by Kant's ideas in Critique of judgment and also by the writings of Goethe and Schelling, Humboldt devised a new interpretation and representation of nature on Earth's surface, wherein the concept of space is essential to explaining natural phenomena. Modern physical geography is grounded in a complex interweaving of aesthetic and instrumental influences fashioned by Humboldt, with the principle of connection playing an important role in the artistic and scientific development of the notion of a geographic landscape.

  19. „Die zweitgrößte Beleidigung des Menschen sei die Sklaverei ...“. Daniel Kehlmanns neu erfundener Alexander von Humboldt

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    Frank Holl

    2012-12-01

    Full Text Available Zusammenfassung Daniel Kehlmann gibt vor, mit seinem Roman Die Vermessung der Welt „verschwiegene oder übersehene Wahrheiten sichtbar“ zu machen. Dadurch, dass er die Leser bewusst im Zweifel lässt, was historisch belegt und was erfunden ist, entstehen Missverständnisse. Der Beitrag analysiert die wichtigsten Charakteristika des Kehlmann‘schen und des historischen Alexander von Humboldt und weist nach, dass diese nicht übereinstimmen. Der Aufsatz fragt nach Kehlmanns Rolle, der in der Öffentlichkeit gerne die Pose des Gelehrten einnimmt, seine Erfindungen jedoch nicht offenlegt und sie als angebliches Humboldt-Zitat sogar in einem wissenschaftlichen Text publiziert. Der Beitrag kommt zu dem Schluss, dass alle, die etwas für ihre Allgemeinbildung tun möchten, bei Die Vermessung der Welt an der falschen Adresse sind. Abstract With his novel Measuring the World, Daniel Kehlmann pretends „to make visible a reticent and ignored truth“. In leaving the reader intentionally in doubt about what is historically proven and what is invented, Kehlmann’s book prompts misreadings. The article compares the main traits of the „Kehlmannian“ against those of the historical Alexander von Humboldt and documents their mis-matching in some central attributes. Moreover, Kehlmann‘s public and self-declared role as an informed scholar is questioned, especially when he uses fictional Humboldt quotes as if they were a matter of fact (i.e. as part of a foreword to a recent text edition on Charles Darwin. The article comes to the conclusion that those interested in general historical knowledge should not take this novel very seriously. Resumen Con su novela La medición del mundo Daniel Kehlmann pretende “de hacer visible una verdad callada e ignorada”. Pero esa verdad es tramposa. El libro de Kehlmann intencionalmente provoca confusiones sobre lo que son los hechos históricos y lo que es pura ficción. Por ende, el artículo compara las

  20. Alexander von Humboldt’s Footnotes: “Networks of Knowledge” in the Sources of the 1826 Essai politique sur l’île de Cuba

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    Anja Werner

    2014-08-01

    Full Text Available Zusammenfassung Alexander von Humboldts Fußnoten waren ihrer Zeit weit voraus, obwohl sie kaum den heutigen akademischen Standards entsprechen. Dieser Artikel untersucht die Fußnoten in Humboldts Essai politique sur l’île de Cuba (1826. Zwar ist es nicht immer leicht, die manchmal recht geheimnisvollen Verweise zu entschlüsseln, dennoch lohnt sich der Versuch: Humboldts Fußnoten geben nicht nur Auskunft über seine umfassenden Netzwerke des Wissens. Sie verweisen auch auf Auseinandersetzungen verschiedener Gelehrter über Humboldts Schriften. Schließlich beinhalten sie Humboldts Reaktionen auf solche Auseinandersetzungen. Eine Untersuchung von Humboldts Fußnoten erlaubt es folglich dem Leser, mehr über Humboldt den Wissenschaftler aber auch Humboldt den Mensch zu erfahren. Abstract When it comes to footnotes, Alexander von Humboldt was ahead of his times even though his references leave much to be desired by today’s academic standards. This article examines the footnotes of Humboldt’s Essai politique sur l’île de Cuba (1826. While it is not always easy to decipher his sometimes cryptic references, the undertaking is worthwhile: Humboldt’s footnotes do not only reveal his vast networks of knowledge. They also provide glimpses of ongoing, contemporary disputes among different scholars that involve Humboldt’s writings. They also present Humboldt’s reactions to such disputes. Exploring Humboldt’s footnotes consequently allows the reader to access both Humboldt the scholar and Humboldt the human being. Résumé Quand il s’agit de notes, Alexandre de Humboldt était en avance sur son temps, même si ses références laissent beaucoup à désirer par rapport aux normes universitaires d’aujourd’hui. Cet article examine les notes de l’Essai politique sur l’île de Cuba (1826. Même s’il n’est pas toujours facile de déchiffrer ses références parfois cryptiques, l’entreprise vaut la peine: les notes de Humboldt

  1. Alexander Disease Mutations Produce Cells with Coexpression of Glial Fibrillary Acidic Protein and NG2 in Neurosphere Cultures and Inhibit Differentiation into Mature Oligodendrocytes.

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    Gómez-Pinedo, Ulises; Sirerol-Piquer, Maria Salomé; Durán-Moreno, María; García-Verdugo, José Manuel; Matias-Guiu, Jorge

    2017-01-01

    Alexander disease (AxD) is a rare disease caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). The disease is characterized by presence of GFAP aggregates in the cytoplasm of astrocytes and loss of myelin. Determine the effect of AxD-related mutations on adult neurogenesis. We transfected different types of mutant GFAP into neurospheres using the nucleofection technique. We find that mutations may cause coexpression of GFAP and NG2 in neurosphere cultures, which would inhibit the differentiation of precursors into oligodendrocytes and thus explain the myelin loss occurring in the disease. Transfection produces cells that differentiate into new cells marked simultaneously by GFAP and NG2 and whose percentage increased over days of differentiation. Increased expression of GFAP is due to a protein with an anomalous structure that forms aggregates throughout the cytoplasm of new cells. These cells display down-expression of vimentin and nestin. Up-expression of cathepsin D and caspase-3 in the first days of differentiation suggest that apoptosis as a lysosomal response may be at work. HSP27, a protein found in Rosenthal bodies, is expressed less at the beginning of the process although its presence increases in later stages. Our findings seem to suggest that the mechanism of development of AxD may not be due to a function gain due to increase of GFAP, but to failure in the differentiation process may occur at the stage in which precursor cells transform into oligodendrocytes, and that possibility may provide the best explanation for the clinical and radiological images described in AxD.

  2. Alexander Disease Mutations Produce Cells with Coexpression of Glial Fibrillary Acidic Protein and NG2 in Neurosphere Cultures and Inhibit Differentiation into Mature Oligodendrocytes

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    Ulises Gómez-Pinedo

    2017-06-01

    Full Text Available BackgroundAlexander disease (AxD is a rare disease caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP. The disease is characterized by presence of GFAP aggregates in the cytoplasm of astrocytes and loss of myelin.ObjectivesDetermine the effect of AxD-related mutations on adult neurogenesis.MethodsWe transfected different types of mutant GFAP into neurospheres using the nucleofection technique.ResultsWe find that mutations may cause coexpression of GFAP and NG2 in neurosphere cultures, which would inhibit the differentiation of precursors into oligodendrocytes and thus explain the myelin loss occurring in the disease. Transfection produces cells that differentiate into new cells marked simultaneously by GFAP and NG2 and whose percentage increased over days of differentiation. Increased expression of GFAP is due to a protein with an anomalous structure that forms aggregates throughout the cytoplasm of new cells. These cells display down-expression of vimentin and nestin. Up-expression of cathepsin D and caspase-3 in the first days of differentiation suggest that apoptosis as a lysosomal response may be at work. HSP27, a protein found in Rosenthal bodies, is expressed less at the beginning of the process although its presence increases in later stages.ConclusionOur findings seem to suggest that the mechanism of development of AxD may not be due to a function gain due to increase of GFAP, but to failure in the differentiation process may occur at the stage in which precursor cells transform into oligodendrocytes, and that possibility may provide the best explanation for the clinical and radiological images described in AxD.

  3. Improving balance and mobility in people over 50 years of age with vision impairments: can the Alexander Technique help? A study protocol for the VISIBILITY randomised controlled trial.

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    Gleeson, Michael; Sherrington, Catherine; Borkowski, Ewa; Keay, Lisa

    2014-02-01

    Falls are an increasingly important and costly public health problem. Vision is key to postural stability as we age and this puts adults with visual impairments at greater risk of falls. Physical interventions improve balance in the general population and in older adults with visual impairments in residential care. They also prevent falls in the general community but to date have not been shown effective in community-dwelling adults with visual impairments. To investigate, with a randomised controlled trial, whether the Alexander Technique (AT) can improve balance and mobility in the community-dwelling population with visual impairments and thus reduce the risk of falls. The AT is a form of physical re-education that has recently received attention for its possible value in rehabilitation. One hundred and twenty people with visual impairments over 50 years of age will be recruited from Guide Dogs New South Wales/Australian Capital Territory (NSW/ACT). Participants will be independently mobile and cognitively able to take part in the programme. After baseline assessment participants will be randomly assigned to two groups. The control group will receive usual care from Guide Dogs NSW/ACT, and the intervention group will receive 12 weekly home-based lessons in the AT in addition to usual care. The primary outcome measures will be physical measures from the short physical performance battery at 3 months. Secondary outcome measures will be balance, mobility, social participation and emotional well-being at 3 and 12 months. The protocol is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12610000634077).

  4. Adult-onset Alexander disease with typical "tadpole" brainstem atrophy and unusual bilateral basal ganglia involvement: a case report and review of the literature

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    Sakoe Kumi

    2010-04-01

    Full Text Available Abstract Background Alexander disease (ALX is a rare neurological disorder characterized by white matter degeneration and cytoplasmic inclusions in astrocytes called Rosenthal fibers, labeled by antibodies against glial fibrillary acidic protein (GFAP. Three subtypes are distinguished according to age at onset: infantile (under age 2, juvenile (age 2 to 12 and adult (over age 12. Following the identification of heterozygous mutations in GFAP that cause this disease, cases of adult-onset ALX have been increasingly reported. Case Presentation We present a 60-year-old Japanese man with an unremarkable past and no family history of ALX. After head trauma in a traffic accident at the age of 46, his character changed, and dementia and dysarthria developed, but he remained independent. Spastic paresis and dysphagia were observed at age 57 and 59, respectively, and worsened progressively. Neurological examination at the age of 60 revealed dementia, pseudobulbar palsy, left-side predominant spastic tetraparesis, axial rigidity, bradykinesia and gaze-evoked nystagmus. Brain MRI showed tadpole-like atrophy of the brainstem, caused by marked atrophy of the medulla oblongata, cervical spinal cord and midbrain tegmentum, with an intact pontine base. Analysis of the GFAP gene revealed a heterozygous missense mutation, c.827G>T, p.R276L, which was already shown to be pathogenic in a case of pathologically proven hereditary adult-onset ALX. Conclusion The typical tadpole-like appearance of the brainstem is strongly suggestive of adult-onset ALX, and should lead to a genetic investigation of the GFAP gene. The unusual feature of this patient is the symmetrical involvement of the basal ganglia, which is rarely observed in the adult form of the disease. More patients must be examined to confirm, clinically and neuroradiologically, extrapyramidal involvement of the basal ganglia in adult-onset ALX.

  5. Evaluation of the potential of Pontederia parviflora Alexander in the absorption of copper (Cu and its effects on tissues = Avaliação do potencial de pontederia parviflora Alexander na absorção de cobre (Cu e efeitos nos tecidos

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    Graziela Custodio Balassa

    2010-07-01

    Full Text Available The study sought to evaluate the potential of the aquatic macrophytePontederia parviflora Alexander in the absorption of copper (Cu and possible variations in its tissues after 21 days of exposure to this metal. The concentration of Cu was analyzed in the solution and in the vegetal tissues (stem, root and leaves. The experiment was set up in triplicates with weekly measurements of pH, temperature and DO. The results indicated that P. parviflora reduced 96% of Cu in the solution and the root was the vegetal tissue, which accumulated more Cu. Values of pH, DO and temperature were in accordance with the metabolic activities of the plants. In the anatomic analyses, dark spots were identified in the vascular bundles and in the epidermis of the aerial parts, highlighting the variation resulting from the presence of this substance. However, these variations were not sufficient to damage the development of the individuals. P. parviflora showed high capacity of extraction and storage of the metal, being a good alternative to aquatic environments with high concentrations of Cu. O estudo avaliou o potencial da macrófita aquática Pontederia parviflora Alexander na absorção de cobre (Cu e possíveis alterações nos tecidos, após 21 dias de exposição. O teor do metal foi analisado na solução e nos tecidos vegetais (caule, raiz e folhas. O experimento foi montado em triplicatas com medidas semanais dopH, temperatura e OD. Os resultados mostraram que P. parviflora reduziu 96% do Cu na solução e a porção vegetal que acumulou mais o metal foi a radicular. O pH, OD e temperatura apresentaram valores condizentes com as atividades metabólicas das plantas. Nas análises anatômicas, foram identificadas manchas escuras nos feixes vasculares e na epiderme das partes aéreas, evidenciando a alteração provocada pela presença da substância. No entanto essas alterações não foram suficientes para prejudicar o desenvolvimento dos indivíduos. P

  6. "Es ist meine Art, einen und denselben Gegenstand zu verfolgen, bis ich ihn aufgeklärt habe" Äußerungen Alexander von Humboldts über sich selbst

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    Ingo Schwarz

    2000-10-01

    Full Text Available Article in German, Abstracts in English and Spanish. Alexander von Humboldt has been characterized as the second, scientific discoverer of the New World, as the last universal scientist, Aristotle of modern times, etc. However, more or less hidden in his correspondence we find certain self-characterizations which are not that well-known. Some of them are quoted and discussed in the paper. Thus, an attempt is made to answer the question why Humboldt liked to call himself "the old man from the mountains", and whether or not he found it appropriate to be called "Aristotle of our age."

  7. Observatoriya imeni russkogo astronoma v dalekoj Brazilii. K 100-letiyu so diya rozhdeniya Aleksandra Ivanovicha Postoeva (1900 - 1976) %t An observatory in distant Brazil named after a Russian astronomer (dedicated to Alexander Postoyev (1900 - 1976) centennial anniversary

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    Marques Dos Santos, P.; Matsuura, O. T.

    This is a biographical note on the life of Dr. Alexander Postoyev, a victim of Stalin's purge of Soviet astronomers in 1936 - 1937. Together with his family, he left the Soviet Union in 1943 and lived in Germany as a refugee and a "displaced person" until 1952, when he moved to Brazil. There, he started the second part of his professional career. Thanks to his efforts, the Astronomical and Geophysical Institute (IAG) of the University of Sao Paulo (USP) was for the first time included in programs of international cooperation, thus contributing to the institutional consolidation of IAG/USP as a leading center of astronomical research and teaching in Brazil now.

  8. Evaluating return on investment in a school based health promotion and prevention program: the investment multiplier for the Stephanie Alexander Kitchen Garden National Program.

    Science.gov (United States)

    Eckermann, Simon; Dawber, James; Yeatman, Heather; Quinsey, Karen; Morris, Darcy

    2014-08-01

    Successful health promotion and disease prevention strategies in complex community settings such as primary schools rely on acceptance and ownership across community networks. Assessing multiplier impacts from investment on related community activity over time are suggested as key alongside evidence of program health effects on targeted groups of individuals in gauging community network engagement and ownership, dynamic impacts, and program long term success and return on investment. An Australian primary school based health promotion and prevention strategy, the Stephanie Alexander Kitchen Garden National Program (SAKGNP), which has been providing garden and kitchen classes for year 3-6 students since 2008, was evaluated between 2011 and 2012. Returns on Australian Federal Government investment for school infrastructure grants up to $60,000 are assessed up to and beyond a two year mutual obligation period with: (i) Impacts on student lifestyle behaviours, food choices and eating habits surveyed across students (n = 491 versus 260) and parents (n = 300 versus 234) in 28 SAKGNP and 14 matched schools, controlling for school and parent level confounders and triangulated with SAKGNP pre-post analysis; (ii) Multiplier impacts of investment on related school and wider community activity up to two years; and (iii) Evidence of continuation and program evolution in schools observed beyond two years. SAKGNP schools showed improved student food choices (p = 0.024) and kitchen lifestyle behaviour (p = 0.019) domains compared to controls and in pre-post analysis where 20.0% (58/290) reported eating fruit and vegetables more often and 18.6% (54/290) preparing food at home more often. No significant differences were found in case control analysis for eating habits or garden lifestyle behaviour domains, although 32.3% of children helped more in the garden (91/278) and 15.6% (45/289) ate meals together more often in pre-post analysis. The multiplier impact on total

  9. Alexander SMIRNITSKIY 1951-2006

    CERN Document Server

    2006-01-01

    It is with great sadness that we learned of the untimely death of Alexandre Smirnitskiy, a talented Russian physicist well known and respected in the heavy ion community. Alexandre was a valued colleague, a dear friend, loving son, husband and father of two children. He died prematurely at the peak of his scientific career, just as his work was beginning to bear fruit. Alexandre’s career is inextricably tied to the Institute for Theoretical and Experimental Physics (ITEP, Russia) where he worked for 30 years. At ITEP he joined and co-authored a number of unique experiments studying collective phenomena in nuclear matter. This research had anticipated by nearly twenty years a number of the issues which are presently included in the nuclear program of the LHC. From the early 1990s, Alexandre Smirnitskiy dedicated his efforts to using gaseous detectors of parallel plate geometry for precise time-of-flight measurements of ionizing particles. He joined the ALICE collaboration with this idea, and the experi...

  10. Obituary: Alexander Dalgarno (1928 - 2015)

    Science.gov (United States)

    Hartquist, Tom; Babb, James F. Babb; Loeb, Avi

    Alex Dalgarno's major contributions to the understanding of fundamental atomic and molecular processes enabled him to develop diagnostics of the physical conditions of atmospheres and astrophysical sources and to elucidate the roles of such processes in controlling those environments. He greatly influenced the research of physicists, chemists, atmospheric scientists, and astronomers, leading Sir David Bates to write, "There is no greater figure than Alex in the history of atomic physics and its applications." Alex was born and grew up in London. As a child, he enjoyed mathematical puzzles and did well at sports. He was invited to try out for the Tottenham Hotspur soccer team, but his professional sporting career ended due to an injury, which did not prevent Alex playing tennis and squash into his ninth decade. In 1945 Alex began to study Mathematics at University College London (UCL). In 1947 Sir Harrie Massey invited him to work for a PhD in Physics and suggested that Alex investigate collisions of metastable helium atoms in helium gas to determine the cross sections for excitation transfer. Richard Buckingham was Alex's immediate supervisor. After completing his graduate study in 1951, Alex became a member of staff in Applied Mathematics at the Queen's University of Belfast (QUB). He served as the Director of the Computational Laboratory after a 1954 visit to MIT, which had an electronic computer, led Alex to persuade colleagues that QUB needed one. In 1957, the poet Philip Larkin was the best man at the marriage of Alex to Barbara Kane. They had four children, Fergus, Penelope, Piers, and Rebecca, but the marriage dissolved after ten years. Alex's important work during the 1950s on the quantitative evaluation of long-range interactions underpinned his collaborations on precise scattering calculations relevant to ultra-cold collisions and the formation of atomic Bose-Einstein condensates over four decades later. He investigated the theory of atomic and molecular collisions and calculated charge transfer cross sections. Some of these proved later to be important for forming the spectra of diffuse astronomical matter surrounding high mass stars and 100 million solar mass black holes at the centers of active galaxies. In the early 1950s David Bates stimulated Alex's interest in the study of quantum processes occurring in the upper terrestrial atmosphere. Together they considered the sources of the nightglow and dayglow features and concluded that the altitudes previously inferred for them from observations were up to several hundred kilometers too large. Experiments carried on V2 rockets, like those seen by Alex in wartime London, proved him and David to be right. Alex felt that though many theorists believe that "physics is embodied in its equations," it is instead "to be found in the solutions to the equations." He was a master at developing and applying methods that simplified calculations leading to reliable solutions. Exploiting the contemporary advances in electronic computation, by the 1960s Alex and his colleagues were able to address atomic and molecular processes of increasing complexity. Their development and early applications of the S-matrix theory of molecular rotational excitation by particle impact triggered major advances in molecular physics and theoretical chemistry and in the understanding of processes important in many environments, including a wide variety of astrophysical sources. In 1967 Alex became a professor in the Harvard Department of Astronomy and a member of the staff of the Smithsonian Astrophysical Observatory. He was a team member for several Atmosphere Explorer satellite missions, which elucidated the roles of atoms and ions in the upper atmosphere and paved the way for further applications to the other planets. By 1969 Alex was publishing papers on molecular hydrogen (H2) radiative processes, including photodissociation, in which the foundations of molecular astrophysics began to emerge. H2 is the most abundant astrophysical molecule and the main constituent of the regions where stars form. Interstellar H2 was first detected directly in the following year, and data for interstellar H2 began to become abundant in 1973. Alex was well prepared and led efforts to interpret these data, from which he was able to infer the physical properties of diffuse interstellar molecular clouds. At nearly the same time he was involved in work on the ionization and energy deposition in H2 by nearly relativistic and relativistic particles called cosmic rays. The work has relevance to emission in the atmospheres of the giant planets, as well as for conditions in interstellar molecular clouds. Cosmic ray induced ionization initiates much of the basic chemistry in star forming regions, and the emissions of the product molecules control the temperatures and allow the diagnosis of the physical conditions and dynamics of the stellar nurseries. For more than four decades Alex elucidated the chemical networks governing the molecular abundances in a wide variety of astrophysical sources including star forming regions, supernova ejecta, the pregalactic universe, and extreme environments like those in the vicinities of X-ray sources powered by accretion onto black holes. The refinement of the models led to calculations predicting the existence of subsequently discovered negative ions in giant molecular clouds. One of his astrophysical interests that intrigued him late in his career was the emission of soft X-rays by comets and in the heliosphere due to charge transfer with solar wind particles, and he also worked on related processes occurring in the atmospheres of the giant planets. Alex remained very active in fundamental atomic and molecular physics, as well as for its applications to astrophysics and to terrestrial and extraterrestrial planetary atmospheres. Ultra-cold collisions and ultra-cold chemistry were major interests for Alex for much of the latest phase of his career, most recently with pioneering work on atom-molecule collisions. In the early 1980s Alex had concerns about the future of atomic, molecular, and optical (AMO) physics in the United States, where it was inadequately funded and somewhat out of fashion in many of the physics departments providing most of the physicists who became university faculty. Alex played a key role in efforts to address this issue and led a proposal to the National Science Foundation that resulted in the founding on 1 November 1988 of the Institute of Theoretical Atomic and Molecular Physics (ITAMP) at the Harvard-Smithsonian Center for Astrophysics. Alex served for five years as the first ITAMP director. A number of the former ITAMP students and postdoctoral researchers have become leading AMO physicists, and its visitor program and workshops have led to the identification and stimulation of the leading areas of AMO physics. Alex was a Fellow of the Royal Society, a member of the National Academy of Sciences, and a member (Honorary) of the Royal Irish Academy. He received many medals, including the Benjamin Franklin Medal in Physics, the Royal Society's Hughes Medal, the Royal Astronomical Society's Gold Medal, the American Geophysical Society's Fleming Medal, and the Royal Society of Chemistry's Spiers Medal. He served as the editor of the Astrophysical Journal Letters for nearly thirty years starting in 1973, as the Chair of the Harvard Department of Astronomy from 1971 to 1976, and as the Acting Director of Harvard College Observatory and then the Acting Director of the Harvard-Smithsonian Center for Astrophysics from 1971 to 1973 during a critical period of its existence. Alex was a gifted mentor who spoke and wrote with pride of his former students and postdoctoral researchers. He was able to match projects very well with the abilities of the students. He made availability to students a special priority, and despite his supply of problems would encourage students as they developed their own. Alex was very supportive of junior scientists as they developed their careers, and in addition to writing many letters of recommendation he made many visits to colleagues as they were establishing themselves elsewhere. Furthermore, Alex very graciously hosted a number of his former students when they visited. He combined quiet modesty with a confidence that reassured others, and his humor was dry, interactive, and friendly. Alex passed away peacefully on 9 April 2015 in Cambridge, Massachusetts in the company of Fern Creelan, who was his partner for 30 years.

  11. Egypt and Greece Before Alexander

    OpenAIRE

    Pfeiffer, Stefan

    2013-01-01

    Egypto-Hellenic contacts, here defined as contacts between the ancient Egyptians and the“haunebut”—the peoples of the Aegean—can be observed since the beginning of Greekcivilization. Both the Minoans and the Mycenaeans had intensive trade relations with Egypt andused Egyptian prototypes to craft their own objects, adapting the original Egyptian meanings intotheir own cultural contexts. In Egypt, Minoan and Mycenaean influence can be traced in thecraftsmanship of pottery and textiles. The rela...

  12. "Educated, intelligent, rather self-controlled, possessing a good deal of cunning and intellect": on some features of personality of the main renegade of 20th century Alexander Osipov prior to transition to service to the atheistic state

    Directory of Open Access Journals (Sweden)

    Ivan Petrov

    2017-12-01

    Full Text Available This article deals with the personality of archpriest Alexander Osipov, the prominent Orthodox priest, who in the middle of the 20th century renounced his faith in God and became an active fi ghter against the Russian Orthodox Church. The main purpose of the article is to comprehend main reasons for Osipov’s abandoning religion, his psychology and main lines of behaviour. Contrary to the lay opinion, this priest, still serving in non-Soviet Estonia, was extremely ambitious and wished rapid promotion. The article specifi cally demonstrates how the renegade could fi nd his key to hearts of various representatives of church and state authorities, how he altered his own political views and denominational preferences. The article shows how he managed to ingratiate himself with representatives of the Orthodox Church, then literally betrayed them and passed compromising judgments to Soviet security offi cers. The article does not raise the issue of where and when Osipov lost his way to God because excessive ambition and envy were always typical of the renegade, and his conversion to atheism was nothing but a tactical step determined by the inception of the new phase of religious persecutions. The article draws on archival materials, both church and secular: Archive of St Petersburg diocese, Central State Historical Archive of St Petersburg, Estonian Historical Archive in Tartu. Besides, the study made use of the historiography of life and work of archpriest Alexander Osipov.

  13. Review Essay: Das "Politische" in den Science & Technology Studies. Eine Replik auf: Niklas Alexander Chimirri (2012. Review: Michalis Kontopodis & Jörg Niewöhner (Hrsg. (2010. Das Selbst als Netzwerk

    Directory of Open Access Journals (Sweden)

    Michalis Kontopodis

    2012-05-01

    Full Text Available Zum Abschluss seiner fundierten Auseinandersetzung mit den theoretischen, epistemologischen und methodologischen Aspekten unseres Buches "Das Selbst als Netzwerk" (KONTOPODIS & NIEWÖHNER 2010 wirft Niklas Alexander CHIMIRRI (2012 eine Frage auf, deren Beantwortung wir innerhalb unserer kleinen deutschsprachigen Einführung ins relational-materielle Denken nicht im Detail leisten konnten: "Does the relational-materialist perspective […] strive for emancipatory transformation, or plainly said, for improving the everyday life of people?" Um auf diese Frage zu antworten und die von Niklas Alexander CHIMIRRI angeregte Diskussion weiterzuführen, werden hier 1. die verschiedenen Konnotationen des Begriffes des Politischen in den Science & Technology Studies unterschieden und eingeordnet, 2. die zentralen Tendenzen der Expertisedebatte und der Biokapitalismuskritik wie auch die zentralen Merkmale von ontological politics identifiziert und 3. die Zusammenhänge zwischen Ethik und Politik im Rahmen von Science & Technology Studies diskutiert. Mit dem Ziel, weitere Arbeiten in diese Richtung anzustoßen, wird somit den deutschen Leser/innen ein Überblick über internationale Debatten zu dieser Thematik dargeboten. http://nbn-resolving.de/urn:nbn:de:0114-fqs1202242

  14. Sternschnuppen und Erdmagnetismus, ein von Alexander von Humboldt und Carl Friedrich Gauß während der Universitätsfeierlichkeiten in Göttingen im September 1837 initiiertes Projekt

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    Karin Reich

    2011-10-01

    Full Text Available AbstractIn September 1837 the centennial celebrations of Göttingen university took place; Alexander von Humboldt, who visited Göttingen for this purpose, and Carl Friedrich Gauss created the project: Do showers of meteors influence the terrestrial magnetic phaenomena, comparable to the aurora borealis? The investigation should take place in November 1837, when strong meteor showers were once again expected. In this context the letter of Humboldt to Gauss from November 30, 1837 is of great importance; in this letter two enclosures were mentioned which still exist, but which were not presented in the edition of the letters between Humboldt and Gauss.One of these enclosures is a letter from Boguslawski to Humboldt from November 15, 1837, on which Humboldt made several remarks. Boguslawski was astronomer at the observatory of Breslau. The other enclosure was a document, containing the observation data of Humboldt and Herter, which were made in Berlin during November 12 to 15 and 21. These two documents together with the historical context are presented here for the first time, accompanied by the report by Gerling on meteor showers observed in Marburg from November 12 to 14.ZusammenfassungWährend der im September 1837 in Göttingen stattfindenden Universitätsfeierlichkeiten initiierten Alexander von Humboldt und Carl Friedrich Gauß gemeinsam ein Projekt; es ging dabei um die Frage, ob Sternschnuppen die erdmagnetischen Erscheinungen beeinflussen würden, dem Nordlicht vergleichbar. Dies sollte im folgenden November, anlässlich des zu erwartenden großen Sternschnuppenschauers, überprüft werden.Im Zentrum dieser Untersuchung steht der Brief von Alexander von Humboldt an Gauß vom 30. November 1837 (Briefwechsel Humboldt-Gauß, S. 63–65; in diesem wurden zwei Beilagen bzw. Anlagen angesprochen, die zwar noch existieren, die aber bei der Ausgabe des Humboldt-Gaußschen Briefwechsels fast ganz unberücksichtigt blieben. Es handelt sich erstens

  15. Alexander von Humboldt y la cooperación transcontinental en la Geografía de las plantas: una nueva apreciación de la obra fitogeográfica de Francisco José de Caldas

    Directory of Open Access Journals (Sweden)

    Alberto Gómez Gutiérrez

    2016-11-01

    Full Text Available Resumen  El Ensayo sobre la geografía de las plantas de Alexander von Humboldt ha trascendido como una de sus principales propuestas científicas, fundamento de lo que se conoce hoy como “biogeografía”. El origen de este concepto es difuso hasta el momento de la publicación simultánea de su obra en París y en Tübingen, en 1807. El presente artículo propone contrastar la primera versión manuscrita de este ensayo, elaborada en 1803 en Guayaquil y luego leída en 1805 en el Institut National de Paris, con la obra contemporánea del neogranadino Francisco José de Caldas, con quien convivió en Quito en el primer semestre de 1802.  Summary  Alexander von Humboldt´s Essay on the geography of plants has been perceived as one of his main scientific theories now referred as “biogeography”. The origin of this concept remains relatively vague up to the simultaneous publication of his work in Paris and Tübingen, in 1807. The present article intends a comparison of Humboldt´s first manuscript, signed in 1803 in Guayaquil and then read in 1805 in the Institut National de Paris, with the contemporary work of Francisco José de Caldas, with whom he lived in Quito during the first semester of 1802.  Résumé  L´Essai sur la géographie des plantes d´Alexander von Humboldt est à la base de sa principale théorie scientifique, généralement adressée aujourd´hui sous le nom de “biogéographie”. Néanmoins, l'origine du concept reste relativement vague jusqu'à la publication simultanée de son travail à Paris et à Tübingen, en 1807. Le présent article propose une comparaison du premier manuscrit, signé par Humboldt en 1803 à Guayaquil, puis lu en 1805 à l'Institut National de Paris, avec le travail contemporain de Francisco José de Caldas, avec qui Humboldt a vécu à Quito au cours du premier semestre de 1802.

  16. Algo más sobre la infundada atribución a Blanco White de la novela «Vargas», de Alexander Dallas, con unas páginas inéditas de Vicente Llorens

    Directory of Open Access Journals (Sweden)

    Fernando Durán López

    2016-07-01

    Full Text Available Este breve artículo aporta algunas evidencias adicionales a las que ya presenté en Cuadernos de Ilustración y Romanticismo, nº 19 (2013, sobre la autoría de Vargas, a tale of Spain, novela escrita por el escritor inglés Alexander Dallas, pero habitualmente atribuida a José María Blanco White. Por una parte, se informa de la localización en la Biblioteca Nacional de Madrid del manuscrito original de Vargas; por otra, se publica un texto inédito de Vicente Llorens con sus argumentos para defender que la obra no fue escrita por Blanco White.

  17. "Ungeheure Tiefe des Denkens, unerreichbarer Scharfblick und die seltenste Schnelligkeit der Kombination" Zur Wahl Alexander von Humboldts in die Königliche Akademie der Wissenschaften zu Berlin vor 200 Jahren

    Directory of Open Access Journals (Sweden)

    Herbert Pieper

    2000-10-01

    Full Text Available Article in German, Abstracts in English and Spanish. On the 17th of July 1800 Alexander von Humboldt was elected as an extraordinary member of the Prussian Académie royale des sciences et belles-lettres at Berlin. The paper first deals with Humboldt’s scientific activities before his election and then goes into detail as far as his integration into the work of the Academy is concerned. Humboldt was elected as a chimiste célèbre, but as a member of the Academy he did not work as a chemist. When Humboldt proposed in 1837 to classify the members of each class in special fields, he chose for himself the field of "mineralogy-geology".

  18. La conversion d’Alexandre le Grand au judaïsme : transpositions et avatars d’une légende dans les Romans d’Alexandre français du XIIe siècle The conversion of Alexander the Great to Judaism in the French Alexander Romances of the XIIth century : transforming and adapting a legend.

    Directory of Open Access Journals (Sweden)

    Isabelle Fabre

    2009-10-01

    proprement parler.Traced back to Josephus Jewish Antiquities and to various rabbinical sources, the legendary encounter between Alexander the Great and the Jews in Jerusalem has given way to many adaptations throughout the Middle Ages and cand be found in particular in vernacular narratives of the XIIth century. Whereas Alexander’s conversion to judaism has often been taken for granted, my purpose here is to reconsider the story and to question such a view completely. Considering that portraying a conversion to judaism was hardly a genuine option for a medieval writer eager to promote the eminent qualities of his heroe, the inquiry will be twofold : first, are we truly confronted here with a conversion narrative ? And if so, is it really about judaism or are we dealing with some subtile forms of christianization ? Or could it be instead that most of the signs commonly associated with religious conversion are made part of a deceptive strategy of some sort or another ? A close literary analysis of the episode in the Alexander Romances by Alexandre de Paris and Thomas de Kent will show that the answer can not be straightforward. If the two versions are quite divergent in their treatment of the episode, both seem to be concerned with narrating an ambiguous meeting between a prince obsessed with personal ambition and a people holding a religious deposit that in the end remain hidden and undisclosed to him.

  19. Icono-grafía, cali-grafía, auto-grafía. Sobre el arte de la visualización en los diarios del viaje americano de Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Ottmar Ette

    2015-05-01

    Full Text Available Zusammenfassung In Gemälden, die den späten Alexander von Humboldt zeigen, finden sich bildlich verdichtete Zeichen seines wissenschaftlichen Lebens. So erinnert das Bild des von Humboldt nicht ganz bestiegenen Chimborazo an die epistemische Funktion des Unabgeschlossenen in seiner Arbeit, während Karte, Globus und die charakteristische Körperhaltung auf die zentrale Bedeutung der Bewegung und auf das „Schreiben im Angesicht der Dinge“ verweisen. Auffällig ist die Präsenz des Schreibmaterials in den Bildern, das als Verweis auf die lebenslange Bedeutung der Amerikanischen Reisetagebücher verstanden werden kann. In diesen kommen wiederum die zentralen Momente der Humboldtian Science zum Ausdruck. Der Charakter des work in progress und die konsequente Relationalität der Darstellung zeigen die epistemologischen Konstanten dieser Wissenschaft genauso an wie die in der Handschrift erkennbare Dimension der Körper-Leiblichkeit. Resumen En las pinturas que retratan al erúdito Alexander von Humboldt encontramos densos signos visuales las cuales simbolizan su vida científica. La imagen del Chimborazo, cuya cima Humboldt no había alcanzado, recuerda la función epistémica de lo inacabado en su obra, mientras que la carta, el globo y su postura típica remiten al central significado del movimiento y al “escribir de cara a las cosas”. La presencia de sus objetos de escritura en las imagenes llama la atención, ya que se puede entender como referencia al significado de los diarios del viaje americano escritos durante toda la vida. En aquellos se ponen de manifiesto los momentos centrales del Humboldtian Science. El carácter del work in progress y la relacionalidad consecuente de la representación muestran las constantes epistemológicas de esta ciencia así como la dimensión de lo corporal en los manuscritos. Summary In the paintings showing the late Alexander von Humboldt, there are figuratively condensed signs of his scientific

  20. „… zu den wunderlichsten Schlangen der Gelehrsamkeit zusammengegliedert“. Neue Materialien zu den ‚Kosmos-Vorträgen‘ Alexander von Humboldts, nebst Vorüberlegungen zu deren digitaler Edition

    Directory of Open Access Journals (Sweden)

    Dominik Erdmann

    2014-08-01

    Full Text Available Zusammenfassung Alexander von Humboldts 1827/28 gehaltene Kosmos-Vorträge stellen ebenso einen kanonischen Bezugspunkt wie einen weißen Fleck in der Rezeption seines Schaffens dar. Zahlreiche Deutungen basieren auf lediglich zwei unkommentierten Leseausgaben von Collegheften anonym gebliebener Zuhörer Humboldts. Seine 2009 wiedergefundenen eigenhändigen Vorlesungsmanuskripte versprechen, diese schmale Quellenbasis zu erweitern. Alfred Dove hatte bereits 1872 auf ihre Existenz verwiesen und interpretierte sie damals als Nukleus der schriftlichen Ausarbeitung des Kosmos. Diese Sichtweise hat sich in der Rezeption gehalten, während die Materialien, die Dove beschrieb, in Vergessenheit gerieten. Der Artikel stellt anhand ausgewählter Beispiele die Vorlesungsmanuskripte Humboldts und Nachschriften seiner Zuhörer in ihrem Zusammenhang vor, entwickelt die These von der Eigenständigkeit der sogenannten Kosmos-Vorträge gegenüber dem fünfbändigen Kosmos und umreißt die wichtigsten Ziele und Inhalte der geplanten digitalen Edition. Abstract Alexander von Humboldt’s famous Kosmos-Lectures, presented in 1827/28, constitute a major benchmark as well as a blind spot in the reception of his work. Numerous interpretations are based on merely two uncommented textbook editions of notes made by anonymous listeners. Humboldt’s own lecture manuscripts, rediscovered in 2009, promise to extend the sources of interpretation. Already in 1872, Alfred Dove gave a hint to the existence of these papers. At that time, he regarded them as the nucleus of the later published Kosmos. This perception persisted up to recent times, while the existence of the papers on which Dove alluded, fell into oblivion. The article presents examples of Humboldt’s own lecture manuscripts together with notes made by his listeners. It develops the thesis of the autonomy of Humboldt’s Kosmos-Lectures towards the Kosmos, but at the same time points to aspects of continuity

  1. ALEXANDER DUGIN AND MOSCOW’S NEW RIGHT RADICAL INTELLECTUAL CIRCLES AT THE START OF PUTIN’S THIRD PRESIDENTIAL TERM 2012-2013: THE ANTI-ORANGE COMMITTEE, THE IZBORSK CLUB AND THE FLORIAN GEYER CLUB IN THEIR POLITICAL CONTEXT

    OpenAIRE

    Andreas UMLAND

    2016-01-01

    The relatively large attention that Alexander Dugin and his “neo-Eurasian” followers have received in international post-Sovietology and Russian right-wing extremism studies, over the last two decades, is unusual, but justified. Dugin represents for both, analytical and political reasons, a more interesting case than his various ultra-nationalist competitors on the book market, in mass media, and within the public discourse of post-Soviet Russia. Not only has he distinguished himself by his b...

  2. Recensión: El Color de la justicia. La nueva segregación racial en Estados Unidos, de Michelle Alexander, Editorial Capitán Swing, Salamanca

    Directory of Open Access Journals (Sweden)

    Silvio Cuneo Nash

    2015-10-01

    Full Text Available The New Jim Crow. Mass Incarceration in the Age of Colorblindness de la connotada jurista Michelle Alexander cuenta con una traducción al español realizada por Carmen Valle y Ethel Odriozola. Esta versión incluye un prefacio de Cornel West. Se trata de una obra esencial y de lectura obligatoria para quien quiera entender el fenómeno del encarcelamiento masivo en EE.UU. Sin embargo, su lectura se recomienda no sólo para quienes estudien el fenómeno norteamericano, puesto que han sido las políticas penales de EE.UU. las que se han exportado a Europa y Latinoamérica y, pese a las especificidades de las distintas sociedades, el sistema penal estadounidense ha servido de ‘modelo’ inspirador de legislaciones y políticas penales en distintas latitudes. Por otra parte, la imposición norteamericana en Latinoamérica ha significado la promulgación de leyes más punitivas (en materia de tráfico de estupefacientes y propiedad industrial, por ejemplo lo que en los hechos ha significado un aumento sin precedentes del número de personas presas.

  3. „Wir verbrachten mehr als 24 Stunden, ohne etwas anderes als Schokolade und Limonade zu uns zu nehmen“. Hinweise in Alexander von Humboldts Tagebuchaufzeichnungen zu Fragen der Verpflegung auf der Forschungsreise durch Spanisch-Amerika

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    Ursula Thiemer-Sachse

    2013-12-01

    Full Text Available Zusammenfassung In Alexander von Humboldts Tagebüchern seiner berühmten Forschungsreise durch Spanisch-Amerika finden sich Bemerkungen und Hinweise für künftige Leser seiner Reisedarstellungen zu Problemen der Verpflegung. Zumeist werden Engpässe und Missstände erwähnt sowie Fragen soziopolitischer Situation verdeutlicht. Sie beziehen sich auf Extrembedingungen in stadtfernen Gebieten und im Kontakt mit den indigenen Trägern und Helfern während der einzelnen Exkursionen. Die Darstellungen der alltäglichen Gegebenheiten sind zugleich eine interessante Quelle für Verhaltensmuster der verschiedenen Schichten der spanischkolonialen Gesellschaft wie der Forschungsreisenden, die mit den Schwierigkeiten umzugehen hatten, sich anzupassen verstanden oder ihre eigenen Verhaltensmuster entwickelt haben. Damit ermöglichen Humboldts Aufzeichnungen zugleich auch auf diesem Gebiet manchen Blick auf den seither erfolgten Kulturwandel. Resumen En los diarios del famoso viaje de estudios de Alejandro de Humboldt por la América española se encuentran observaciones y notas sobre problemas de aprovisionamiento, en favor de lectores futuros de sus relaciones de viaje. En la mayoría de los casos Humboldt menciona situaciones precarias o ilustra cuestiones de carácter sociopolítico. Frecuentemente, sus apuntes se refieren a condiciones extremas en regiones remotas y en contacto con los cargadores y ayudantes indígenas durante las diferentes excursiones. Las descripciones de los acontecimientos cotidianos al mismo tiempo son una fuente interesante sobre los modos de proceder de las diferentes capas de la sociedad colonial española así como de los viajeros científicos que tuvieron que enfrentar dificultades a las cuales había que adaptarse o desarrollar modelos propios de comportamiento. Por esto al mismo tiempo las noticias de Humboldt también en este asunto posibilitan más de una vez la atención al cambio cultural que se ha realizado hasta hoy

  4. Cultural Memory on "Great" People in a "Small" Town: The Perception of King Alexander Karađorđević and Marshal Josip Broz Tito in the Cultural Memory of Samobor

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    Danijel Vojak

    2015-08-01

    Full Text Available Starting from the thesis that ''history is written by the winners”, ''mainstream'' history can be under¬stood as the revised and politically instrumentalized means of a certain nation's ''cultural'' memory, which some consider to be a ''history of selective memo¬ri¬zation and selective forgetfulness''. Most approaches in con¬temporary Croatian historiography which are focu¬sed on the historical periods of monarchist and socialist Yugoslavia use national-level themes as their starting point. A similar preoccupation is also present in those historiographical approaches which are focused on the problems of analyzing and understanding how collective memories are constructed. However, our aim here is to move from the ''big'' themes to a ''small'' (local setting. In this context, Samobor, a small Croatian urban centre, is going to serve us as the basis for analyzing in which way two Yugoslav rulers – King Alexander Karađorđević and Marshal Josip Broz Tito – were perceived on the local level. By analyzing the relevant archival sources as well as contemporary periodicals, we seek to un¬der¬stand the ways in which local authorities and elites, from their position of social power and status, received the mentioned rulers during their visits, and in which ways did they honour and commemorate these high-profile guests. Through this analysis, we hope to gain a better understanding of the process of the creation of local social memory, the constitution of memorial and cul¬tural patterns, and their key cultural elements and me¬anings, which are often torn apart during periods of social and political upheaval, only to be reconstituted by recombining the same key cultural and social elements while simultaneously encompassing new actors. In other words, the focus of our analysis will be on tracing the collective memory of the population of Samobor to¬wards two ''great leaders''. Starting from the thesis that ''history is written by the winners

  5. Reforming Of The Penology System Of Russia At The Beginning Of The Xix Century: From The Ideas Of Catherine Ii To The Attempt Of Their Embodiment During Alexander I's Ruling

    Directory of Open Access Journals (Sweden)

    Maksim V. Smolyarov

    2014-09-01

    Full Text Available In the present article author analyzed reforming of the penology system of Russia at the beginning of the XIX century, which was based first of all on humanistic views of the empress Catherine II. In her wars she briefly considered main types of punishment which could be applied to the criminal, proclaimed the need for crimes prevention. Laid ideological foundation had a serious impact on the further modernization of penology system during Alexander I ruling. Within the article author pays particular attention to the formation and development of public-government institution – Societies of trustee about prisons which had to deal with issues of "nearest and constant surveillance over prisoners"; assist them in rules of Christian piety and kind moral; "occupy them by decent exercises" and so on. Author considers that Society of trustee about prisons had a certain positive impact on the development of penal system of Russia, adjustment of interaction of the penalty system and public structures, reforming of the punishments execution system in the spirit of European values. According to the author, ideas of the empress Catherine II had positive impact on the change of penitentiary policy of the Russian Empire in the XIX century. Introduction of Society of trustee about prisons in 1819 became the first positive practical step of authorities on the interaction with society for the penal system reforming. In modern Russian state it is important to use historical experience, at the present stage encouraging creation of independent public structures for resocialization of citizens who served sentence in the form of imprisonment, conduct of the independent control over the system of punishments execution. Positive historical experience can be used at the present stage through the implementation of certain provisions into the Concept of the criminal and executive system of the Russian Federation development until 2020.

  6. Diskursiewe patrone in Brandwaterkom van Alexander Strachan ...

    African Journals Online (AJOL)

    The primary narrator is a Hermes-figure who constantly reflects upon the narrative in metafictional fashion, questioning and even belittling his own omniscience and omnipotence as narrator. The main story centres on Fanie Vilonel, a traitor during the Boer War, and the motif of treachery is central in the story, discourse and ...

  7. Port Alexander Alaska Coastal Digital Elevation Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA's National Geophysical Data Center (NGDC) is building high-resolution digital elevation models (DEMs) to support individual coastal States as part of the...

  8. Jevropeiskii biznes gorko platshet / Alexander Rahr

    Index Scriptorium Estoniae

    Rahr, Alexander

    2008-01-01

    Ilmunud ka: Den za Dnjom 2. mai lk. 20, Stolitsa 5. mai lk. 5. Venemaale ja Ida-Euroopa riikidele spetsialiseerunud Saksa politoloogi ettekanne Tallinna linna korraldatud Kodurahu Foorumil, kus põhitähelepanu oli Euroopa riikide suhetel, sh suhetel Venemaaga ning Euroopa poliitika tulevikuperspektiividel. Vahendanud Tatjana Opekina

  9. Does Estonia need foreign policy? / Alexander Astrov

    Index Scriptorium Estoniae

    Astrov, Alexander

    2003-01-01

    Autori arvates vajab Eesti kindlaksmääratud poliitikasuundade asemel rohkem välispoliitikat laiemas mõttes, vajalik oleks loobuda viimase aastakümne eesmärgikesksest ratsionaalsusest enam kontekstitundliku tegutsemis- ja mõtlemisviisi kasuks

  10. Alexander Bort and the Bortian Blobs

    Science.gov (United States)

    McCormack, Alan J.

    1978-01-01

    Presents an imaginative story to be used to introduce elementary school students to the different properties and uses of "Polyox." Various ideas for using "Polyox" in elementary science are given. (MDR)

  11. 27 CFR 9.53 - Alexander Valley.

    Science.gov (United States)

    2010-04-01

    ...., R. 8 W., to the point at which an unnamed unimproved road which parallels the south bank of Martin....), Range 10 West (R. 10 W.), on the Asti Quadrangle map, the boundary runs— (1) West along the north line of Sections 32 and 31, T. 12 N., R. 10 W., and Sections 36, 35, and 34, T. 12 N., R. 11 W., to the...

  12. Alexander, Hannibal, and Scipio in Lucian

    Directory of Open Access Journals (Sweden)

    Barry Baldwin

    1990-06-01

    Full Text Available Not much has been written about this particular Dialogue of the Dead. What there is, apart from noting the obvious fact of it being a comic syncrisis, concentrates on the role of Scipio and Lucian's alleged historical errors throughout the piece. But there is much more to be said about correlation of satire and history in the piece. And the supposed historical errors melt away upon examination. This paper also encompasses two new topics: a general review of the dialogue and its theme in terms of both genre and topicality, and some possible internal evidence for redating it to a later period than has hitherto been done.

  13. Juhile tekitab pingeid segane kohanemisaeg / Alexander Kotchubei

    Index Scriptorium Estoniae

    Kotchubei, Alexander, 1963-

    2006-01-01

    Suur risk vastuolude tekkimiseks organisatsioonis kaasneb uue keskastmejuhi töölevõtmisega, mille põhjuseks on kohanemisperioodi puudumine. Vt. samas: Arenev konflikt vajab jahutamist; Juhtide omavahelises vastuolus kannatab ettevõte

  14. Alexander the Great Universal project in Babylon الإسكندر المقدوني ومشروعه العالمي في بابل

    Directory of Open Access Journals (Sweden)

    Dr. Qays Hatim Hani al-Janabi أ.م.د. قيس حاتم هاني الجنابي

    2015-01-01

    Full Text Available Alexander the Great was one of the most famous figures of the old history. He succeeded to extend his authority to many of the old world countries to control an area that had never been controlled before. He inherited courage, boldness, and strength from his father, plus beauty and delicacy from his mother. That greatly enabled him to get the likelihood of his people. He used to respect the cultures of the peoples he invaded and that led to a kind of acceptance on the part of the people who became under his control. The unique characteristics, he had, helped him much in his endeavor to create an international unified empire collecting all the peoples of the world in one country. He could achieve part of his dream but his sudden death at the age of youth put an end.

  15. Illustrated and online catalog of type specimens of freshwater fishes in the Colección de Peces Dulceacuícolas of Instituto de Investigación de Recursos Biológicos Alexander von Humboldt (IAvH-P), Colombia.

    Science.gov (United States)

    Donascimiento, Carlos; Cárdenas-Bautista, Johann-Stephens; Acosta, Kevin Giancarlo Borja; González-Alvarado, Arturo; Medina, Claudia A

    2016-09-29

    The catalog of type specimens of freshwater fishes deposited in the Colección de Peces Dulceacuícolas del Instituto de Investigación de Recursos Biológicos Alexander von Humboldt (IAvH-P) is presented. This list includes 483 specimens in 65 lots representing 11 holotypes and 472 paratypes of 48 nominal species. Corrections, additions, and updating of information in the original descriptions are included in individual remarks for each catalog number entry and a gallery of pictures of holotypes or paratypes of each nominal species is also presented, which supplements some original descriptions lacking figures of their respective types. An online version of the catalog is available at http://humboldt.org.co/en/servicios/colecciones-biologicas/catalogo-de-tipos.

  16. Alexander Stubb: koostööleping Venemaaga peab tulema / Alexander Stubb ; interv. Krister Paris

    Index Scriptorium Estoniae

    Stubb, Alexander, 1968-

    2008-01-01

    Soome välisminister usub, et parim viis Venemaa kaasamiseks Euroopas on Venemaa tihedam integreerimine Euroopaga, seega on koostööleping kohustuslik. Vene-Saksa gaasijuhtme puhul on Soome jaoks küsimus keskkonnas

  17. ALEXANDER DUGIN AND MOSCOW’S NEW RIGHT RADICAL INTELLECTUAL CIRCLES AT THE START OF PUTIN’S THIRD PRESIDENTIAL TERM 2012-2013: THE ANTI-ORANGE COMMITTEE, THE IZBORSK CLUB AND THE FLORIAN GEYER CLUB IN THEIR POLITICAL CONTEXT

    Directory of Open Access Journals (Sweden)

    Andreas UMLAND

    2016-12-01

    Full Text Available The relatively large attention that Alexander Dugin and his “neo-Eurasian” followers have received in international post-Sovietology and Russian right-wing extremism studies, over the last two decades, is unusual, but justified. Dugin represents for both, analytical and political reasons, a more interesting case than his various ultra-nationalist competitors on the book market, in mass media, and within the public discourse of post-Soviet Russia. Not only has he distinguished himself by his bold incorporation of West European inter- and post-war right-wing extremist ideas – including classical German Nazism – into his post-Soviet Russian fascist ideology. By today, he is one of the few still active veterans of the Soviet Union’s occult underground, entering the Iuzhinskii circle in the early 1980s (Menzel 2013, 195-228, Laruelle 2015b, 563-580. Later on, Dugin was, for a short period in 1988, a member of late Soviet Russia’s first openly ultra-nationalist grouping, the infamous so-called Pamiat’ (Memory Society. Already in the early nineties, Dugin became a prolific post-Soviet publicist whose first articles, in particular his columns for Russia’s leading ultra-nationalist weekly Den’/Zavtra (The Day/Tomorrow, helped to shape the overall world-view of the then emerging new Russian extreme right. This paper will, first, outline the overall background, determinants, and context of the type of non-party activities that, among others, Dugin is engaged in. The argument focuses on both Dugin’s specific strategy, on the side, and the general meaning of right-wing extremist activism outside the electoral realm, i.e. within so-called “uncivil society,” on the other. The paper, secondly, illustrates these general observations by way of continuing Marlene Laruelle’s (2009 and others’ (including my own, Umland 2007 research on post-Soviet Russian right-wing extremist clubs and think-tanks. The focus here will be on three new such

  18. Spectra and dynamics of small molecules Alexander von Humboldt lectures

    CERN Document Server

    Field, Robert W

    2015-01-01

    These seven lectures are intended to serve as an introduction for beginning graduate students to the spectra of small molecules. The author succeeds in illustrating the concepts by using language and metaphors that capture and elegantly convey simple insights into dynamics that lie beyond archival molecular constants. The lectures can simultaneously be viewed as a collection of interlocking special topics that have fascinated the author and his students over the years. Though neither a textbook nor a scholarly monograph, the book provides an illuminating perspective that will benefit students and researchers alike.

  19. Development of a multi-year climate prediction model | Alexander ...

    African Journals Online (AJOL)

    The available water resources in Southern Africa are rapidly approaching the limits of economic exploitation. The situation is compounded by claims that global warming will have a serious adverse effect on future water supplies. There was therefore an urgent need to characterise the numerical properties of the ...

  20. A Measurement of "g" Using Alexander's Diving Bell

    Science.gov (United States)

    Quiroga, M.; Martinez, S.; Otranto, S.

    2010-01-01

    This paper describes a very simple exercise using an inverted test tube pushed straight down into a column of water to determine the free-fall acceleration "g". The exercise employs the ideal gas law and only involves the measurement of the displacement of the bottom of the "diving bell" and the water level inside the tube with respect to the…

  1. Refraction and essay film: the case of Alexander Sokurov

    OpenAIRE

    Nasirov, Yasin

    2017-01-01

    Cataloged from PDF version of article. Thesis (M.S.): Bilkent University, Department of Communication and Design, İhsan Doğramacı Bilkent University, 2017. Includes bibliographical references (leaves 121-125). This thesis analyzes refraction in essay film. As a self-reflexive method, refraction deals with the self-critique of visual representation in essay film. In this thesis, I develop two different dimensions of post-aesthetics of essay film in the line of semio-ideologic...

  2. Memorial to Martin Alexander Baumhoff (1926-1983)

    OpenAIRE

    Thomas, David Hurst

    1984-01-01

    M. A. Baumhoff, Professor of Anthropology at the University of California, Davis, was born in Camino, California, on December 22, 1926. He died of cancer on March 27, 1983. After joining the Davis faculty in 1958, he served as Chairman of the Department of Anthropology from 1963 to 1966. For the next two years, during the heyday of so-called student unrest, he was the Vice Chancellor of Student Affairs at Davis.

  3. [Alexander Pushkin's duel--biographic and medical aspects].

    Science.gov (United States)

    Tangen, J M

    2000-04-10

    The great Russian poet Aleksandr Pushkin (1799-1837) died 46 hours after being wounded by a pistol shot in a duel. The bullet penetrated the right pelvic bone, continued through the lower abdomen, and crushed the right part of the sacral bone. Biographical events leading to the duel are presented in the article, which also reviews articles in Russian medical journals describing the extent of the trauma and discussing the treatment possibilities at the time of the duel as well as present-day treatment. It is concluded that death was caused by peritonitis and that only modern extensive abdominal and orthopaedic surgery combined with antibiotic treatment could have saved the poet's life.

  4. Menschewiken in Stockholm vor und nach 1917 / Alexander Kan

    Index Scriptorium Estoniae

    Kan, Alexander

    2005-01-01

    Rootsi sisserännanud menševikest ja bolševikest, nende koostööst rootsi sotsiaaldemokraatidega, vene revolutsionääride tagasipöördumisest Venemaale Veebruarirevolutsiooni järel, repatrieerujaid toetanud Abikomitee tegevusest

  5. The death of Alexander the Great | Retief | Acta Theologica

    African Journals Online (AJOL)

    ... Liber de morte testamentumque Alexandri Magni. The theory that he was poisoned is rejected, as is the hypothesis that he drank himself to death. His final illness shows symptoms characteristic of malignant tertian malaria (Plasmodium falciparum), possibly precipitated by recent wounds, exhaustion and heavy drinking.

  6. Biografías: Alexander G. Bell, Thomas Alva Edison

    OpenAIRE

    Medina, Carlos

    2009-01-01

    En Biografías, queremos dar a conocer a grandes personajes que con su sed de conocimiento y su grandioso ingenio, han guiado el avance de la tecnología y han contribuido en forma positiva a la humanidad. En esta edición, presentamos a dos grandes creadores, cuyos inventos tuvieron y siguen teniendo un gran impacto en nuestras vidas diarias.

  7. Alexander von Humboldt and British artists: the Oriental taste

    Directory of Open Access Journals (Sweden)

    Garrido, Elisa

    2013-12-01

    Full Text Available Humboldtian landscape is the best result of a close relationship between artists and scientists in the context of the Enlightenment. Many artists inspired Humboldt to develop his concept of landscape as the best way of representing Nature, but some British artists in particular were a strong reference for him. Thomas Daniell and William Hodges had travelled to Asia creating a particular imagery, which inspired the desire to travel and the feeling of the exotic taste in Humboldt. Around Humboldt, mainly two types of artists have been studied: on the one hand, painter travellers who received direct instructions from Humboldt after his experience in America, and on the other, artists who started their trips by themselves after reading his works. However, this paper is focused on the links between Humboldt and these British painters of the Orient, whom he met on a European tour with Georg Forster, before making his trip to America.El paisaje teorizado por Humboldt es el resultado de una estrecha relación entre artistas y científicos, en el contexto de la Ilustración. Muchos artistas inspiraron a Humboldt a desarrollar su concepto del paisaje como la mejor forma de representar la naturaleza pero particularmente, algunos artistas británicos supusieron una fuerte referencia para él. Principalmente, alrededor de Humboldt se han estudiado dos tipos de artistas: por una parte, los pintores viajeros que recibieron instrucciones directas de Humboldt tras su experiencia en América y por otra, los artistas que iniciaron sus viajes por iniciativa propia tras haber leído los sus trabajos. Sin embargo, este texto se centra en las relaciones entre Humboldt y los pintores británicos de Oriente, a quienes él conoció en su viaje europeo junto a Georg Forster, antes de realizar su viaje americano.

  8. the army of alexander the great and combat stress syndrome

    African Journals Online (AJOL)

    diers per 1000, and in Vietnam PTSD was identified in 10-12 per 1000. (although the observation of patients over a longer period revealed a much higher prevalence — at least 20%). In the Angolan border war, the long-term incidence was 26% (Louw 1989). 1.2 Clinical picture. Combat stress has a very varied symptom ...

  9. Learning to See the Ball Using the Alexander Technique

    Science.gov (United States)

    Gosselin, Gaynelle

    2011-01-01

    This article begins with a personal anecdote from the author, for whom childhood P.E. classes were exercises in frustration and humiliation largely because she could not master the coordination needed to catch, throw, or hit a ball. She could not keep her eye on the ball despite well-meaning instruction from coaches, friends, and family members.…

  10. Päästke Läänemeri! / Alexander Stubb

    Index Scriptorium Estoniae

    Stubb, Alexander, 1968-

    2007-01-01

    Euroopa Parlamendi Euroopa Rahvapartei ja Euroopa Demokraatide (ERP-ED) fraktsiooni Soome delegatsiooni liige põhjendab keskkonnale, majandusele ja transpordile keskenduva Läänemere strateegia vajalikkust

  11. The transport glider | Alexander | Scientia Militaria: South African ...

    African Journals Online (AJOL)

    The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader). If you would like more information about how to print, save, and work with PDFs, Highwire Press provides a helpful Frequently Asked Questions about PDFs.

  12. Biographical memoir: Alexander Beaumont Hope, Australian biophysicist, 1928-2008.

    Science.gov (United States)

    Barry, Peter H; Coster, Hans G L; Chow, Wah Soon

    2009-12-01

    This introductory article is the first of four short articles from the Tribute to Alex Hope Symposium held at the 2008 Australian Society for Biophysics meeting in Canberra, Australia, as a tribute to Professor Alex Hope, who died in July last year. As well as briefly introducing the other three articles by three former PhD students, it will also be a biographical memoir of Alex Hope.

  13. John Alexander Sinton, MD FRS VC (1884-1956).

    Science.gov (United States)

    Cook, G C

    2016-05-01

    Brigadier John Sinton is the only individual in history to have been both awarded the Victoria Cross and also elected to the Royal Society. He qualified at Belfast and afterwards joined the Indian Medical Service (IMS). Serving before and during the Great War (1914-18), he was first posted to the North-West Frontier province, and afterwards as a captain in the Indian Expeditionary force in Mesopotamia (now Iraq). It was there in 1916 that, shot in both arms during an engagement and under heavy gunfire, he remained steadfastly at his post; for this bravery he received the Victoria Cross. Following the war he carried out major researches into malaria in India, and became Director of the Malaria Survey of India Both there and shortly afterwards, Sinton published about 200 papers on various aspects of malaria and leishmaniasis. In England, he later worked at the London School of Hygiene and Tropical Medicine and the Ministry of Health's laboratory at Horton, Epsom. In 1946, he was elected to the Royal Society for his researches into malaria and kala-azar, and following retirement he underwent another distinguished career in Northern Ireland. © The Author(s) 2014.

  14. Howard Florey, Alexander Fleming and the fairy tale of penicillin.

    Science.gov (United States)

    Goldsworthy, Peter D; McFarlane, Alexander C

    2002-02-18

    The public myth of the discovery of penicillin is an archetypal "quest story" of the type common to every human culture. But the real story of the discovery, testing and refinement of penicillin is a complex tale of accident, serendipity, oversight, conflict, the pressure of war, idiosyncratic personalities and even--the invention of history.

  15. Alexander Rahr: algamas on uus külm sõda / Alexander Rahr ; interv. Külli-Riin Tigasson

    Index Scriptorium Estoniae

    Rahr, Alexander

    2007-01-01

    Saksamaa Vene-eksperdi hinnangul saab praegu Venemaal valitsevat ärritunud õhkkonda seletada alandustundega. Venelastel on jäänud mulje, et nad on Euroopast kõrvale tõrjutud. Venemaa-küsimuses on Euroopa lõhestunud. V. Putini presidendiaja suurimatest vigadest ja tema õigetest otsustest

  16. Portraits in medical biography: Alexander Pope (1688-1744), poet, patient, celebrity.

    Science.gov (United States)

    James, Douglas

    2013-11-01

    Portraits are underused in the medical biographies of patients, yet they can illuminate health concerns and even health itself in many ways. Tying portraiture and medicine together analytically yields many insights into Pope's medical biography - from his response to satirical ridicule to his friends' concern for his health - without abandoning his portraits as works of 'art'.

  17. A Darwinian mystery: fluctuations in runoff from the la Plata basin (Alexander von Humboldt Medal Lecture)

    Science.gov (United States)

    Clarke, R. T.

    2012-04-01

    During the voyage of HMS Beagle, Charles Darwin sailed in a small boat along the River Paraná, a major tributary of the la Plata drainage system. He wrote about the occurrence of severe droughts (the latest of which had been termed the "gran seco") alternating with periods of severe flooding. From reports received, he concluded that these events appeared to be cyclic with a period "of about fifteen years". Because extended periods of low flow in Brazilian rivers are of immense economic importance, the presentation describes a search for the material which led Darwin to this conclusion. A prolonged period of low flow in another la Plata tributary - the River Paraguay - not unlike the "gran seco" reported by Darwin, has occurred more recently; if such low flows were to recur in the future, the consequences would be severe for a region where more than 70% of energy is supplied by hydropower. A priori considerations suggest the use of statistical long-memory models for predicting River Paraguay water-levels, and some preliminary results from their use are presented.

  18. Alexander Disease and Megalencephalic Leukoencephalopathy with Subcortical Cysts: Leukodystrophies Arising from Astrocyte Dysfunction

    Science.gov (United States)

    Gorospe, J. Rafael; Maletkovic, Jelena

    2006-01-01

    Disorders of white matter are some of the most commonly encountered conditions in the practice of child neurology. For a child presenting with evidence of neurological impairment, a magnetic resonance imaging (MRI) of the brain is usually performed and often proves informative in suggesting the diagnosis. Traditionally, primary white matter…

  19. Ultrastructural aspects of spermatogonesis in Metamicrocotyla macracantha (Alexander, 1954 Koratha, 1955 (Monogenea; Microcotylidae

    Directory of Open Access Journals (Sweden)

    Maria de Fatima Diniz Baptista Farias

    1995-10-01

    Full Text Available Ultrastructural aspects of spermatogenesis, spermiogenesis and of the mature spermatozoon of a microcotylid monogenean Metamicrocotyla macracantha parasite from Mugil liza, are described. The irregularly-shaped spermatogonia divides by successive mitoses, forming the primary spermatocytes, identified by the presence of synaptonemal complexes in their nuclei. The spermatids formed by meiotic cell divisions of the secondary spermatocytes, differentiate into a mature spermatozoon. Cross sections of the head and the middle region of mature spermatozoa show the nucleus with strong condensed chromatin, the mitochondria with short cristae, peripheral microtubules and two axonemes with a 9+1 pattern, confirming the characteristics of this genus.

  20. Alexander the Great: A Strategy Review in the Context of the ACSC strategy Process Model

    Science.gov (United States)

    1984-03-01

    Pharaoh of Egypt. 331 Defeat of Darius at Battle of Arabia. 327-326 Advances into India. Defeat of Porus at Battle of Hydaspes . 323 Dies at Babylon, age 32 years. 39 ...39 i v iv LIST OF ILLUSTRATIONS I . Figure 1. Initial Orders of Battle At Arbela ....... .24 Figure 2. The Battle of...left wing of his father’s army at the dec ive battle of Chaeronea in which Philip defeated the allied Greek forces 1 won control of Greece. Philip

  1. Blahopřání Alexandře Navrátilové

    Czech Academy of Sciences Publication Activity Database

    Frolcová, Věra

    2016-01-01

    Roč. 33, č. 2 (2016), s. 159-162 ISSN 1211-8117 Institutional support: RVO:68378076 Keywords : congratulations * ethnology * anniversary * personality Subject RIV: AC - Archeology, Anthropology, Ethnology

  2. A history of Nigerian Coal Production from 1909-2010 | Alexander ...

    African Journals Online (AJOL)

    The negligence on the part of the federal and state governments in the areas where this mineral resource is found in abundance has led to an almost complete collapse of the industry. The study concludes that a lot could still be done to ameliorate the fallen state of the industry such as the employment of specialist mining ...

  3. Cyrillo-Methodian Studies in scientific works of archpriest Alexander Gorsky

    Directory of Open Access Journals (Sweden)

    Melkov Andrey Sergeevich

    2013-11-01

    Full Text Available The article is devoted to the 1150th anniversary of Slavonic writing language and culture. The work analyses scientific researches of archpriest A. Gorsky (1812-1875 in main problems of Cyrillo-Methodian Studies. Gorsky made a great contribution in solving key problems, connected with the biographies, church honouring, and homiletic glorifying of the Slavonic enlighteners. The results of the researches, made by Gorsky in the middle of the 19th century are actual our days. Accumulated and systematized material opens wide prospects for further Cyrillo-Methodian Studies by modern generation of Slavonic scholars.

  4. Actas Alexander: la extracción de la información.

    Directory of Open Access Journals (Sweden)

    Esteban Dörries

    2016-03-01

    Full Text Available Después de una descripción del proceso histórico de demarcación de la frontera norte de Costa Rica, se detallan los datos contenidos en las llamadas “Actas Alexander” y se explican posibles criterios de comparación con la realidad física fronteriza. Se exponen los problemas que se presentaron en la extracción de datos y su tipificación. Las diversas herramientas matemáticas y cartográficas permitieron obtener, cotejar y definir la validez de la información.

  5. 77 FR 35028 - Bill Alexander, M.D.; Decision and Order

    Science.gov (United States)

    2012-06-12

    ... Corrective Order against Applicant's medical license. Id. According to the ] allegations, the Texas Board... after closing his medical practice in late 2008, he agreed to transport marijuana for a drug... Board took no action against Applicant's medical license other than to impose a $500 administrative...

  6. Presentación atípica de la enfermedad de Alexander infantil sin macrocefalia

    Directory of Open Access Journals (Sweden)

    Carmen Esmer

    2016-05-01

    Conclusiones: Los signos radiológicos en la resonancia fueron determinantes para el diagnóstico, que posteriormente se confirmó con estudio molecular. Es importante considerar que ciertas mutaciones no se asocian con macrocefalia, lo cual puede ocasionar retraso en el diagnóstico.

  7. Digitizing Alexander Grahan Bell’s Beinn Bhreagh for its conservation

    Directory of Open Access Journals (Sweden)

    Mario Santana Quintero

    2014-04-01

    Full Text Available This paper describes Carleton Immersive Media Studio (CIMS and Heritage Standing collaboration for the application of digital technologies for the rehabilitation and conservation of an important heritage place called the Beinn Bhreagh House.  The series of accurate architectural drawings produced will be used for undertaking a project that aims to develop and apply a methodology for the documentation, rehabilitation and conservation of this important landmark in the province of Nova Scotia.

  8. Väga suur ja vana, aga ikka pooleli / Alexander Birnbaum

    Index Scriptorium Estoniae

    Birnbaum, Alexander

    2007-01-01

    Bologna San Petronio Basilica ehk Püha Petroniuse katedraalist. Kiriku fassaadist, interjöörist, seal asuvast päikesekellast. Lühidalt Strasbourgi, Kölni, Siena, Milano ja Barcelona Sagrada Familia katedraalide ehitamisest

  9. Alexander von Humboldt und Carl Friedrich Gauß – im Roman und in Wirklichkeit

    Directory of Open Access Journals (Sweden)

    Eberhard Knobloch

    2012-12-01

    Full Text Available Zusammenfassung Daniel Kehlmanns Roman „Die Vermessung der Welt“ wird hoch gepriesen und streng kritisiert. Kehlmanns Kritiker lesen seine Satire als eine verfälschte Biographie von Gauss und Humboldt, obwohl der Autor wiederholt selbstironische Bemerkungen eingestreut hat, die sein wahres Ziel offenbaren. Der Aufsatz bemüht sich, Kehlmanns fiktiven Roman angemessen zu beurteilen und einige der wirklichen Aktivitäten und Errungenschaften von Gauss und Humboldt zu charakterisieren, indem Kehlmanns erzählte mit den historischen Tatsachen verglichen werden. Beide Wissenschaftler waren stark am Erdmagnetismus interessiert, was zeitweise zu einigen Spannungen zwischen ihnen führte. Humboldts Messmethoden und seine Überzeugung, dass alles Wechselwirkung ist, waren zwei Seiten derselben Medaille. Nur numerische Elemente konnten helfen, die Gesetze zu finden, die die Natur regieren. Humboldts wissenschaftliche Techniken und Ziele (Methode der Mittelwerte waren gut begründet. Humboldts Reisen und Forschen bildeten eine untrennbare Einheit. Humboldts Naturbegriff schloss beide Möglichkeiten ein, das heißt die natura naturans und die natura naturata, die schaffende und herrschende Natur und die Natur, die von bestimmten Gesetzen beherrscht war. Sein überragendes Interesse an Naturgesetzen gründete auf der Überzeugung, dass sie ewig waren und dass sie die Ordnung und Ewigkeit der Welt garantierten. Résumé Le roman de Daniel Kehlmann „Le mesurage du monde“ est célébré et critiqué fortement en même temps. Les critiques de Kehlmann lisent sa satire comme une biographie détériorée de Gauss et de Humboldt quoique l’auteur ait inséré à maintes reprises des remarques autoironiques qui révèlent sa vraie fin. L’article s’efforce de juger justement le roman fictif de Kehlmann et de caractériser quelques-unes des activités et conquêtes réelles de Gauss et de Humboldt en comparant les faits racontés par Kehlmann avec les faits historiques. Les deux savants s’intéressaient beaucoup au magnétisme terrestre ce qui entraînait quelques désaccords pendant quelques années. Les méthodes humboldtiennes de mesurage et sa conviction que tout est interaction étaient deux côtés de la même médaille. Seulement des éléments numériques pouvaient aider de découvrir les lois de la nature. Les techniques scientifiques et les fins de Humboldt (la méthode des valeurs moyennes étaient bien fondées. Ses voyages et ses recherches formaient une unité inséparable. La notion humboldtienne de nature incluait les deux possibilités, à savoir la natura naturans et la natura naturata, la nature créative et gouvernante et la nature gouvernée par certaines lois. Son intérêt extraordinaire aux lois de la nature était basé sur sa conviction qu’elles sont éternelles and qu’elles garantissent l’ordre et l’éternité du monde. Abstract Daniel Kehlmann‘s novel „The measuring of the world“ is highly praised and strongly criticized as well, Kehlmann‘s critics read his satire as a deteriorated biography of Gauss and Humboldt though the author repeatedly inserted self-ironical remarks that reveal his true aim. The paper tries to do justice to Kehlmann‘s fictional novel and to characterize some of Gauss‘s and Humboldt‘s real activities and achievements by comparing Kehlmann‘s narrative with historical facts. Both scientists were strongly interested in earth magnetism that temporarily led to some tensions between them. Humboldt‘s measuring methods and his conviction that everything is interaction were two sides of the same medal. Only numerical elements could help to find the laws ruling the world. Humboldt‘s scientific techniques and aims (method of mean values were well founded. Humboldt‘s travelling and researching formed an unseparable unity. Humboldt‘s notion of nature implied both possibilities, that is natura naturans and natura naturata, the creative and governing nature and the nature governed by certain laws. His outstanding interest in natural laws.

  10. Book Review: A Far-Away War: Angola 1975-1989 | Alexander ...

    African Journals Online (AJOL)

    Abstract. Book Title: A Far-Away War: Angola 1975-1989. Book Authors: Ian Liebenberg, Jorge Risquet and Vladimir Shubin (Eds.) Stellenbosch: Sun Media 2015, 207 pages. ISBN 978-1-920689-72-8 e-book ISBN 978-920689-73-5 ...

  11. ON THE SACRED MEANING OF "THE STATION MASTER" BY ALEXANDER PUSHKIN

    Directory of Open Access Journals (Sweden)

    Ivan Andreevich Esaulov

    2012-11-01

    Full Text Available In the article the author demonstrates the diference between the external “study“ and the internal “comprehension“ of the artistic text on the example of Pushkin’s masterpiece – The Station Master. Studying and comprehension are not synonymical. The German didactic pictures on the walls of the station master’s home are by no means an adequate analogue of the Parable of the Prodigal Son, but rather its moralistic simplification. In his artistic intuition Pushkin follows the evangelical logic of miracle and not the legalistic logic of the German pictures. In the end, the heroine finally performs a return, albeit it is her father's grave that she returns to. She herself 'dies' in her sole function of being just a daughter to the station master, but at the same time is 'resurrected' as a person who sloves and is loved. In the prosaic world there is a place for love, which can be compared to wonder – such is the deep meaning of the Pushikin’s text.

  12. Vielschichtigkeit und Komplexität im Reisewerk Alexander von Humboldts - Bibliographischer Hintergrund

    Directory of Open Access Journals (Sweden)

    Ulrike Leitner

    2005-04-01

    Full Text Available Article in German, Abstracts in English, German and Spanish.The network structure of Humboldt’s American travel journals with emphasise on the bibliographic background is investigated on the basis of O. Ette’s concept of Humboldtian writing. The complexity of Humboldt’s writing is shown in the following dimensions: splitting up into disciplines, hypertext structure of singular texts, multilinguality, connections to Humboldt’s oeuvre and correspondence, Humboldt’s network in the scientific community. This specific structure cannot be fully understood in a strictly linear reading (which is what a regular book asks for, especially because of the lack of a new indexed edition of his travelogues. Therefore, a digital library could be an adequate medium to represent Humboldt’s scientific writing and, consequently, for his specific organisation of knowledge.

  13. Book Abstract: How to Write an Emergency Plan by David Alexander; Reproduced by Permission

    Directory of Open Access Journals (Sweden)

    David Alexander

    2016-07-01

    Contents: Foreword. 1. Introduction. Scope and objectives of this book; 2. What are emergencies? 3. What is an emergency plan? 4. The emergency planning process; 5. First step: background research; 6. Second step: scenario building; 7. Third Step: from scenarios to actions; 8. A note on the structure of the plan; 9. Fourth step: using the plan; 10. Planning to maintain the continuity of normal activities; 11. Specialized emergency planning; 12. Conclusion: the future of emergency planning. Afterword. Appendix 1: Glossary of working definitions by key terms. Appendix 2: Bibliography of selected references. Index.

  14. 78 FR 30791 - Airworthiness Directives; Alexander Schleicher GmbH & Co. Segelflugzeugbau Sailplanes

    Science.gov (United States)

    2013-05-23

    ... abbreviation for Technische Mitteilung. The English translation for Technische Mitteilung is Technical Note... 11, 1964) the European Aviation Safety Agency (EASA), which is the Technical Agent for the Member... technical investigation revealed a misalignment in the automatic elevator control connection, presumably...

  15. Actas Alexander: La elaboración de la información.

    Directory of Open Access Journals (Sweden)

    Esteban Dörries

    2016-03-01

    Full Text Available Para comparar la información obtenida de las “Actas Alexander” con la situación actual, se diseñó, midió y calculó una campaña GPS a lo largo de la parte amojonada de la frontera norte. La transformación de coordenadas en diversas variantes, junto a otros criterios, permitió realizar el estudio comparativo de los mojones fronterizos.

  16. Hydrologic Impacts of Climate Change: Quantification of Uncertainties (Alexander von Humboldt Medal Lecture)

    Science.gov (United States)

    Mujumdar, Pradeep P.

    2014-05-01

    Climate change results in regional hydrologic change. The three prominent signals of global climate change, viz., increase in global average temperatures, rise in sea levels and change in precipitation patterns convert into signals of regional hydrologic change in terms of modifications in water availability, evaporative water demand, hydrologic extremes of floods and droughts, water quality, salinity intrusion in coastal aquifers, groundwater recharge and other related phenomena. A major research focus in hydrologic sciences in recent years has been assessment of impacts of climate change at regional scales. An important research issue addressed in this context deals with responses of water fluxes on a catchment scale to the global climatic change. A commonly adopted methodology for assessing the regional hydrologic impacts of climate change is to use the climate projections provided by the General Circulation Models (GCMs) for specified emission scenarios in conjunction with the process-based hydrologic models to generate the corresponding hydrologic projections. The scaling problem arising because of the large spatial scales at which the GCMs operate compared to those required in distributed hydrologic models, and their inability to satisfactorily simulate the variables of interest to hydrology are addressed by downscaling the GCM simulations to hydrologic scales. Projections obtained with this procedure are burdened with a large uncertainty introduced by the choice of GCMs and emission scenarios, small samples of historical data against which the models are calibrated, downscaling methods used and other sources. Development of methodologies to quantify and reduce such uncertainties is a current area of research in hydrology. In this presentation, an overview of recent research carried out by the author's group on assessment of hydrologic impacts of climate change addressing scale issues and quantification of uncertainties is provided. Methodologies developed with conditional random fields, Dempster-Shafer theory, possibility theory, imprecise probabilities and non-stationary extreme value theory are discussed. Specific applications on uncertainty quantification in impacts on streamflows, evaporative water demands, river water quality and urban flooding are presented. A brief discussion on detection and attribution of hydrologic change at river basin scales, contribution of landuse change and likely alterations in return levels of hydrologic extremes is also provided.

  17. Feldenkrais Method, Alexander Technique, and yoga--body awareness therapy in the performing arts.

    Science.gov (United States)

    Schlinger, Marcy

    2006-11-01

    The three disciplines described are practiced by many individuals for a myriad of reasons. Depending upon ability and depth of study, teachers of all three disciplines may have specific competencies with which to analyse, instruct, and interact with students/clients. In the author's experience, persons who seek out these practices and incorporate them into their daily lives and expressions of physical activity often are motivated to maintain or establish an optimal state of well-being and function. Physicians and therapists who work with performing artists are in a position to encourage such positive direction in patients, provide information on local resources, and consider the practices as collaborative and adjunctive to medical care.

  18. Lo público y lo privado en los escritos de Alexander Von Humboldt sobre Cuba

    Directory of Open Access Journals (Sweden)

    Rebok, Sandra

    2004-12-01

    Full Text Available This study seeks to collect the comments and judgements that Humboldt makes about Cuba and evaluate their character. The resulting analysis and interpretation will be undertaken on two different levels: One refers to the information that can be found in his unofficial works, which means the letters Humboldt sent during or shortly after of his visits to Cuba, as well as the diaries he used during his expedition. The other is based on the official works, which include his travel description, his famous Essay on Cuba and his autobiographical text written in 1804. Constrasting these descriptions, we will compare the evaluations of this Prussian traveller elaborated in the moment he visited the island, with the works he wrote 22 years after his return to Europe.

    Este trabajo tiene el objeto de recopilar los comentarios y juicios que hace Humboldt sobre Cuba y valorar su carácter. El análisis e interpretación que resultará de ello se realiza en dos niveles distintos: uno se refiere a las informaciones que se encuentran en escritos no oficiales, es decir, en las cartas que Humboldt envió durante o poco tiempo después de sus visitas a Cuba, y en los diarios que utilizó a lo largo de su expedición. El otro se fundamenta en los escritos oficiales, que comprenden su narración del viaje, el famoso Ensayo sobre Cuba y la memoria autobiográfica escrita en 1804. Mediante el contraste de estas descripciones se pretende comparar las apreciaciones de este viajero prusiano elaboradas en el preciso momento que visita la isla, cotejándolas con las obras que redactó 22 años después de su vuelta a Europa. Este trabajo tiene el objeto de recopilar los comentarios y juicios que hace Humboldt sobre Cuba y valorar su carácter. El análisis e interpretación que resultará de ello se realiza en dos niveles distintos: uno se refiere a las informaciones que se encuentran en escritos no oficiales, es decir, en las cartas que Humboldt envió durante o poco tiempo después de sus visitas a Cuba, y en los diarios que utilizó a lo largo de su expedición. El otro se fundamenta en los escritos oficiales, que comprenden su narración del viaje, el famoso Ensayo sobre Cuba y la memoria autobiográfica escrita en 1804. Mediante el contraste de estas descripciones se pretende comparar las apreciaciones de este viajero prusiano elaboradas en el preciso momento que visita la isla, cotejándolas con las obras que redactó 22 años después de su vuelta a Europa.

  19. Ettevõte peab tegelema innovatsiooniga, mis ennast ka ära tasub / Alexander Kandybin

    Index Scriptorium Estoniae

    Kandybin, Alexander

    2010-01-01

    Autor analüüsib innovatsiooni tõhususe mõõdikuid. Skeemid: Innovatsioonitõhususe kõver ; Innovatsiooniinvesteeringu kogutulusus ja käibekasv ; Tõhususkõvera tõstmine. Tabel: Innovaatorite seitse tüüpi

  20. Virtuti et merito. El reconocimiento oficial de Alexander von Humboldt en España.

    Directory of Open Access Journals (Sweden)

    Sandra Rebok

    2004-04-01

    Full Text Available Article in Spanish, Abstracts in English, Spanish and GermanThis article studies the recognition of Humboldt and his works at a late moment of his life, during the reign of Isabel II (1844-68, when in 1847 he received in Potsdam the Gran Cruz of the Real y Distinguida Órden Española de Carlos III, founded by Carlos III in 1771 and given since then to selected person for special merits related to the Court. We also publish the unknown letter that Humboldt sent to the prince Sotomayor to express his gratefulness for the decoration awarded to him (9th of August 1848. In this study are also included his prior appointments as correspondent member of the Real Jardín Botánico, the Real Academia Médica Matritense as well as the Real Academia de Ciencias, whose president Antonio Remón Zarco del Valle seems to have a significant importance related to the political recognition of the reign of Isabel II by the central European governments.

  1. Funciones de los astrocitos en las enfermedades neurodegenrativas: Enfermedad de Alexander

    OpenAIRE

    Nae, María Magdalena

    2016-01-01

    Los astrocitos han sido considerados como células de sostén en el Sistema Nervioso central (SNC). Sin embargo, hoy día se sabe que participan de forma activa en muchas de las funciones del SNC y que pueden tener un papel destacado en las enfermedades neurodegenerativas. Existen numerosas evidencias de que las alteraciones de la función astrocitaria pueden contribuir al desarrollo, e incluso provocar patologías en el SNC, especialmente patologías neurodegenerativas. Por un lado,...

  2. A comparison of regression algorithms for wind speed forecasting at Alexander Bay

    CSIR Research Space (South Africa)

    Botha, Nicolene

    2016-12-01

    Full Text Available to forecast 1 to 24 hours ahead, in hourly intervals. Predictions are performed on a wind speed time series with three machine learning regression algorithms, namely support vector regression, ordinary least squares and Bayesian ridge regression. The resulting...

  3. port_alexander_ak_1-3_mhw.new.grd

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NGDC builds and distributes high-resolution, coastal digital elevation models (DEMs) that integrate ocean bathymetry and land topography to support NOAA's mission to...

  4. The Warrior Who Would Rule Russia: A Profile of Alexander Lebed.

    Science.gov (United States)

    1996-01-01

    sults" from Lebed attested to the latter’s " maniacal desire for power." Kulikov, whose troops had done much of the day-to-day fighting in Chechnya...counsel on the ap- pointment of Rodionov to replace Grachev was a resounding testa- ment to Lebed’s access and influence, at least in the defense and...116 The Warrior Who Would Rule Russia For his part, Lebed now controls Russia’s defense and security policy portfolio and commands access to the

  5. Alexander Graham Bell Association for the Deaf and Hard of Hearing

    Science.gov (United States)

    ... Your Stories Family Resources Employment and Legal Resources Parents and Families Blogs Professionals Bookstore Career Center Hearing and Hearing Technology Child Development Parent Guidance, Education and Support Listening and ...

  6. Idee elluviimisel peab juht saavutama kiiresti veendumuse selle edukuses / Alexander Kotchubei

    Index Scriptorium Estoniae

    Kotchubei, Alexander, 1963-

    2005-01-01

    Ilmunud ka: Juhi ideelaegas. - Tallinn, 2006, lk. 83-85. Ärijuhid leiavad end sageli olukorrast, kus neil tuleb välissurve mõjul tegutseda ilma sisemise veendumuseta, et projekt on õige või õigeaegne. Vt. samas: Projekti kiiret õnnestumist pärsib liigse heakskiidu ootamine teistelt osapooltelt

  7. La participación en el urbanismo de Christopher Alexander vista en nuestros días

    National Research Council Canada - National Science Library

    Jorge Insulza Contardo

    2015-01-01

    .... Sin embargo, sin pretender descifrar toda su evolución, ya que ello significa una investigación de mayor tiempo, si podemos extraer aquellas situaciones en donde se han visto efectos reales en el escenario urbano...

  8. CMDT E.G.M. ALEXANDER, CMDT G.K.B. BARREN AND CDR A.A. ...

    African Journals Online (AJOL)

    BARREN AND CDR A.A. BATEMAN: SOUTH. AFRICAN ORDERS DECORATIONS AND. MEDALS (160pp). This book was written by authors representing the SA Army, Air Force and Navy each an auth- ority in his field, and is the standard reference on the subject of South Africa's many prestigious military and civil awards.

  9. Riigi õigused ja kohustused Läänemerre heidetud keemiarelvade suhtes. Mere-, keskkonna- ja julgeolekuõigus / Alexander Lott

    Index Scriptorium Estoniae

    Lott, Alexander, 1987-

    2012-01-01

    Läänemerre heidetud keemiarelvade kogustest, asukohtadest ja uputamise põhjustest. Keemiarelvade merre heitmise õiguspärasusest, nendele kohalduvast õigusest ning riikide kohustusest uputatud keemiarelvad hävitada

  10. Alexander Pope and the Comma Splice, or, Contradictions and Problems in College Composition--An Administrator's View.

    Science.gov (United States)

    Bataille, Robert R.

    The training of doctoral candidates in English often does not match the kind of teaching they must do upon taking their first jobs: namely, training is in literature, while most jobs are available in composition. Even when acceptable composition teachers are found, keeping them in the face of budgetary restraints and declining enrollments is…

  11. The telephone patent conspiracy of 1876 the Elisha Gray-Alexander Bell controversy and its many players

    CERN Document Server

    Evenson, A Edward

    2001-01-01

    ""Useful""--Public Library Quarterly; ""interesting insight...entertaining""--TCI Singing Wires; ""fascinating story""--Chicago Tribune. From court testimony, contemporary accounts, government documents, and the participants' correspondence, a fascinating story emerges. This book recounts the little-known story in full, relying on original documents (most never published) to preserve the flavor of the debate and provide an authentic account. Among the several appendices is the ""lost copy"" of Bell's original patent, the document that precipitated the charge of fraud against the Bell Telepho

  12. 9th Alexander Friedmann International Seminar on Gravitation and Cosmology and 3rd Satellite Symposium on the Casimir Effect

    CERN Document Server

    Petrov, V M

    2016-01-01

    The objective of the meeting is to promote contacts between scientists working in the field of Relativity, Gravitation and Cosmology and related fields. It is well known that the important role in Gravitation and Cosmology is played by the Casimir effect. To underline this, special Satellite Symposia devoted to this effect have been included in the Programs of the 7th and 8th Friedmann Seminars. The Casimir effect is a multidisciplinary subject. Its applications extend from gravitation and cosmology to the van der Waals forces, materials properties and nanotechnology. All these subjects are traditionally touched at the Satellite Simposia on the Casimir effect.

  13. AN ANTHOLOGY OF THE DISTINGUISHED ACHIEVEMENTS IN SCIENCE AND TECHNIQUE. PART 31: PORTRAIT OF THE KHARKIV PHYSICIST ALEXANDER ILYICH AKHIEZER

    Directory of Open Access Journals (Sweden)

    M.I. Baranov

    2016-05-01

    Full Text Available Purpose. Description is in the short form of the basic distinguished scientific achievements, features of personality and way of life of the known Kharkov physicist-theorist A.I. Akhiezer. Methodology. Existent scientific approaches for treatment and systematization of physical knowledges. Methods of historical method at research of development in human society of basic sections of theoretical physics. Results. Short information is resulted about the basic creative and vital stages, and also fundamental scientific achievements of the indicated prominent physicist of the XX century. Some personal qualities of this Kharkov physicist-theorist, becoming a founder known in the world of physical school are described. Originality. First the Kharkov scientist-electro-physicist for the wide circle of readers imagined a short scientifically-historical essay the known physicist of contemporaneity, being based on his scientific labours and published materials about him. Practical value. Scientific popularization of creative activity of the known Kharkov physicist and his achievements in area of theoretical physics. Next reminder a wide reader on the example of creative life in science and got prominent scientific results of labour of one human personality known in the scientific world about incessant in modern society connection of times and generations.

  14. Archaeological Survey Within Designated Portions of the Proposed Len Small Floodway in Dogtooth Bend, Alexander County, Illinois

    Science.gov (United States)

    2005-01-01

    tlM.Np M.MNM.aa M .aIIM,p 1 ..p m NEaRm . .N..Mmmmv.v.IN,.W. .MM . . .N ....I .MM.INN MM.. norma Eir _ama mum .M.Y NMmpNmmp.I.1. .N or .M.1 .laM...PY•ANNPNVf ...1•.W1NANV.. PNMNff PP /PN•N/AMAWA NN NW. HAPWWtl f•.R .•N1PW.tl/vxPW1W1W/ ... APA HWWII•NN•• ....A1M.. ••1.AA1.111.1 P _]MiN...Mm• AY .m.MNmmNMM./mtlMM MAWNp AMPAWxNVWOWMmPAMPA x.vvW Niiii .NA1VWWm1•NN: CMN mWMpm /fAMWY maroonsAmur.. MEP AMP. APA ~MWMA/AWtl/MNMu

  15. Michelle Alexander, The New Jim Crow: Mass Incarceration in the Age of Colourblindness, The New Press, 2012, 304

    OpenAIRE

    Mansley, David

    2017-01-01

    Among social historians of law there is currently a keen interest in popular legalism, i.e. in the active role that ordinary people played in the judiciary and how these people experienced the law. These new strands of research takes the view that ordinary people were not necessarily the victims of legal regimes imposed upon them from above. Instead, historians increasingly highlight the ways in which ordinary people shaped the judiciary. This historiographical shift includes growing attentio...

  16. Alexander von Humboldt y la comparación de las esclavitudes en las Américas

    Directory of Open Access Journals (Sweden)

    Miachel Zeuske

    2005-10-01

    Full Text Available This article has two main aims. Both are motivated by the Humboldtian diary about Cuba in 1804, unknown until today (found by Ulrike Leitner in the Biblioteka Jagiellonska Kraków. First, the article will present the in fact discontinuous but coherent development of the Humboldtian image of slavery in Spanish America (which is culminating to some extent in the diary and builds in nuce what later will become the “Essay on the Island of Cuba”. Second, the article presents the sensation in history of science, that Humboldt starts to apply systematically main elements of scientific method of comparison on social, historical and socioeconomic themes of slavery, when he heard of the proclamation of the new state of “Haity” in Veracruz or Havana in 1804. These two findings (and the diary itself are changing profoundly our knowledge about Humboldt’s political relationship with two larger groups of the population of Spanish America (the parts of the Creole elite who were planning to found “a white republic”, following the French model and the very large group, or caste, of the “pardos” on the “Eve of the Independence Movement”.

  17. Die neue CSR-Richtlinie – Erhöhung der Unternehmenstransparenz in Sozial- und Umweltbelangen / Alexander Eufinger

    Index Scriptorium Estoniae

    Eufinger, Alexander

    2015-01-01

    Euroopa Liidu direktiivist, mis käsitleb finantsteabe avalikustamist teatavate suurettevõtjate ja kontsernide poolt (2014/95) ning eriti ettevõtjate poolt esitatava sotsiaalse ja keskkonnaalase teabe läbipaistvusest

  18. Wilsonian visions of a new world order in concrete terms : the case of William C. Bullitt / Alexander Sedlmaier

    Index Scriptorium Estoniae

    Sedlmaier, Alexander

    2003-01-01

    President Wilsoni internatsionalismi ideede pooldajast, vasakpoolse poliitika kriitikust pärast I maailmasõda Ameerika - Saksamaa suhete taustal, ajakirjanikust ja diplomaadist William C. Bullitt'ist (1891-1967)

  19. Conversations with Four Highly Productive German Educational Psychologists: Frank Fischer, Hans Gruber, Heinz Mandl, and Alexander Renkl

    Science.gov (United States)

    Flanigan, Abraham E.; Kiewra, Kenneth A.; Luo, Linlin

    2018-01-01

    Previous research (Kiewra & Creswell, "Educational Psychology Review" 12(1):135-161, 2000; Patterson-Hazley & Kiewra, "Educational Psychology Review" 25(1):19-45, 2013) has investigated the characteristics and work habits of highly productive educational psychologists. These investigations have focused exclusively on…

  20. The Impression of Reality and the Awareness of the Medium in Alexander Sokurov’s Family Trilogy

    Directory of Open Access Journals (Sweden)

    Bugaj Malgorzata

    2016-09-01

    Full Text Available Drawing on Brigitte Peucker’s question – “in cinematic experience, what promotes the impression of reality, and when does medium awareness come into play?” – I examine how Sokurov’s family trilogy constitutes a certain oscillation between the immediate and the constructed. The films under discussion connect with the sensual, physical-biological and socio-political reality, while, simultaneously, they emphasize the artificial and stylised. Mother and Son employs distancing painterly images which deemphasise the figures of the characters while it finishes with the extreme close-up exploring the skin as a raw material used to construct image with its varied colours and textures. Father and Son, on the other hand, enters the dialogue with medicine; through the employment of haptic images and medical appropriations, the film focuses on the sensual along with the biological dimension of the body. Set within a clear socio-political context, Alexandra explores the senses which are not readily available in cinema, that is touch and smell, and thus emphasises the trace of the physical presence on screen. This paper demonstrates how Sokurov’s family trilogy situates itself on the intersection of the Bolter and Grusin’s “desire for immediacy” with the mediated and remediated.

  1. Conservative Protective Program of Development of the Russian Society during the Reign of Alexander II (1860-1880s

    Directory of Open Access Journals (Sweden)

    Maksim N. Krot

    2013-12-01

    Full Text Available The article is focused on the conservative protective concept of the development of the Russian society during the first post-reform decades (60-80s of the XIX century. The author determines and considers key features of conservative understanding of social progress, such as the priority of spiritual values over material, abandoment of society reforming in accordance with abstract concepts, intention to proceed from the existing social and political realias of the Russian society. Special attention is attached to the disclosure of concervative concept of country modernization within the framework of the estates strata in accordance with the dictates of the times and the model of the correlation of new establishments and institutes with the existing social, economic, cultural and moral principles of the country, offered by the conservatives. The author came to the conclusion that conservative concept of the development of post-reform Russia is the integral element of the country modernization. Its authors and supporters considered that its essence is the addition and balancing of liberal and reform component of this process.

  2. [Anja Wilhelmi. Lebensweltlen von Frauen der deutschen Oberschicht im Baltikum (1800-1939). Eine Untersuchung anhand von Autobiographien] / Alexander Ewig

    Index Scriptorium Estoniae

    Ewig, Alexander, 1980-

    2011-01-01

    Arvustus: Wilhelmi, Anja. Lebenswelten von Frauen der deutschen Oberschicht im Baltikum (1800-1939). Eine Untersuchung anhand von Autobiographien. (Veröffentlichungen des Nordost-Instituts, 10.) (Wiesbaden : HArrassowitz 2008)

  3. Audiovisual correspondences in Sergei Eisenstein’s Alexander Nevsky: a case study in viewer attention\\ud

    OpenAIRE

    Smith, Tim J.

    2014-01-01

    Cognitive film theory is an approach to analyzing film that bridges the traditionally segregated disciplines of film theory, philosophy and the psychological and neurosciences. Considerable work has already been presented from the perspective of film theory that utilizes existing empirical evidence of psychological phenomenon to inform our understanding of film viewers and the form of film itself. But can empirical psychology also provide ways to directly test the insights generated by the th...

  4. Alexander Theodor von Middendorffi tegevus Liivimaa põllumajanduse edendajana ning tema seosed eesti rahvusliku liikumisega / Erki Tammiksaar

    Index Scriptorium Estoniae

    Tammiksaar, Erki, 1969-

    2006-01-01

    Middendorffi tegevusest Peterburis Peterburi Vabamajanduse Seltsi presidendina ja II ülevenemaalise põllumajandusnäituse organiseerijana. Middendorffi agraarpoliitilistest veendumustest, tegevusest Liivimaa Üldkasulikus ja ja Ökonoomilises Sotsieteedis, Middendorffi osast Aleksandrikooli probleemi segapuntras. Kuukirjast Eesti Põllomees ja Middendorffi suhetest J. V. Jannseniga

  5. Innovaatiline mõtlemine nõuab juhilt julgust kastist välja tulla / Alexander Kotchubei

    Index Scriptorium Estoniae

    Kotchubei, Alexander, 1963-

    2005-01-01

    Ilmunud ka: Juhi ideelaegas. - Tallinn, 2006, lk. 194-196. Uuenduslikkuse aluseks on konkurentidest efektiivsem mõtlemine. Vt. samas: Tänapäeva juht peab olema avatud ja riskijulge; Uusi ideid soodustavad muudatused mõtteviisis

  6. Kas missioon on moesõna või organisatsiooni "töövahend"? / Alexander Kotchubei

    Index Scriptorium Estoniae

    Kotchubei, Alexander, 1963-

    2004-01-01

    Autor selgitab missiooni olemust, selle sõnastamise vajalikkust organisatsioonis ning arutleb võimalike põhjuste üle, miks missioon ei toimi. Kommenteerivad Marie Edala ja Urmas Kaarlep. Lisa: Sõnumi kujundamiseks vali kahe lähenemise vahel. Vt. samas: Kuidas viia missiooni töötajateni?

  7. La Vegetación de los Páramos La Aguada, La Fría y Espejo en los Andes Venezolanos /Alexander Berg & Stefan Suchi

    OpenAIRE

    Berg, Alexander; Suchi, Stefan

    2001-01-01

    The vegetation of the páramos La Aguada, La Fría and Espejo in the ±Sierra Nevada de Mérida» National Park (Venezuela) is analyzed using phytosociological methods. Floristic composition, vegetation structure and some ecological aspects are treated. Anthropogenic factors are discussed for selected communities. The spatial distribution of the communities in an area of about 1.400 ha, ranging from 3.000 to 4.980 m a.s.l., is shown in a vegetation map at a 1:15.000 scale. Forests of Podocarpus ol...

  8. A Chapter of the Critique of Affective Reason: The analisis of «Gesinnungen» according to Alexander Pfänder

    Directory of Open Access Journals (Sweden)

    Mariano Crespo

    2014-11-01

    Full Text Available Pfänder’s analysis of Gesinnungen represents first chapter of what would be called a «phenomenology of emotive conscience» or a «critique of affective reason». This early – unfortunately little known – phenomenologist offers a detailed analysis of special kind of experiences and tries also to show their moral significance. This paper points out the main elements of Pfänder’s contribution to a recovery of emotions moral relevance.

  9. A Comparison of the Dynamical Evolution of Planetary Systems Proceedings of the Sixth Alexander von Humboldt Colloquium on Celestial Mechanics Bad Hofgastein (Austria), 21–27 March 2004

    CERN Document Server

    Dvorak, Rudolf

    2005-01-01

    The papers in this volume cover a wide range of subjects covering the most recent developments in Celestial Mechanics from the theoretical point of nonlinear dynamical systems to the application to real problems. We emphasize the papers on the formation of planetary systems, their stability and also the problem of habitable zones in extrasolar planetary systems. A special topic is the stability of Trojans in our planetary system, where more and more realistic dynamical models are used to explain their complex motions: besides the important contribution from the theoretical point of view, the results of several numerical experiments unraveled the structure of the stable zone around the librations points. This volume will be of interest to astronomers and mathematicians interested in Hamiltonian mechanics and in the dynamics of planetary systems.

  10. Aus der Vorgeschichte der Aufforderung Alexander von Humboldts von 1836 an den Präsidenten der Royal Society zur Errichtung geomagnetischer Stationen

    Directory of Open Access Journals (Sweden)

    Kurt-R. Biermann

    2005-10-01

    Full Text Available Article in German, Abstracts in English, German and French.From the history of A. v. Humboldt's appeal of 1836 to the President of the Royal Society to establish geomagnetic stations (Documents on the relations between A. v. Humboldt and C. F.GaußLetters of A. v. Humboldt to astronomers, partly unpublished, shed new light on the origin of his well-known appeal of 1836 which led to the establishment of geomagnetic observation stations all over the world. They show that its final version seriously strained his relations to C. F. Gauß. At the same time they give us a better view of the ways of thinking and working of these two great scientists.

  11. Could the Addition of Alexander Technique Improve the Effectiveness of Physical Therapy in Reducing Violinists' Neck Pain in Comparison to Physical Therapy Alone?

    Science.gov (United States)

    Taheri, Arman; Lajevardi, Mahbod; Shabani, Sanaz; Emami, Sara; Sharifi, Hassan

    2017-03-01

    One hypothesis for the mechanism of neck pain in musicians, particularly string players, is changed behavior of the superficial neck flexor muscles and impairment of the cervical stabilization system. To restore the supporting capacity of neck muscles and reduce neck pain, various types of physical therapies and pain educational modalities have been recommended. However, considering the physio-psychological nature of violinists' neck pain, its treatment may benefit from addition of therapies that address postural and movement habits. In this regard, we suggest that management of violinists' neck pain might benefit from additional approaches that may help to decrease muscle overactivity during performance movements.

  12. Ironical Wanderer. Based on the blog “Archemistry and Absurdecture” by Olga Ermolaeva and Alexander Rappaport (http://papardes1.blogspot.ru/

    Directory of Open Access Journals (Sweden)

    Konstantin Lidin

    2016-11-01

    Full Text Available An ironical way of world perception is peculiar not only to the absurd art. A detached metacultural ironical view is utterly tolerant, because it refers to no one moral-aesthetical system. Visual collages of the blog “Archemistry and Absurdecture” by O. Ermolaeva and A. Rappaport are remarkably ironical: while robbing the familiar visual objects of their meaning, they give those objects new unexpected and paradoxical meanings.

  13. Publication of Renaissance architectural treatises in the Soviet Union in the 1930s: Alexander Gabrichevsky's contribution to the theory and history of architecture

    Directory of Open Access Journals (Sweden)

    Nadejda Podzemskaia

    2016-06-01

    Full Text Available : In just a couple of years in the second half of the 1930s, a considerable corpus of architectural treatises, mostly written in the Renaissance, was translated and published with detailed commentaries in the USSR. This great publishing program was conceived of as part of a new system of architectural training. This article formulates the question of the historical and cultural significance of this publishing project in the wider artistic and political context of the 1920s and 1930s. In discussions about the destiny of classical heritage, two majors tendencies, constructivism, represented by Moisei Ginzburg, and classicism, advocated by Ivan Zholtovsky, show not only their differences, but also their shared positions, such as the criticism of eclecticism. The paper concentrates on the collaboration between Zholtovsky and the art historian and theorist Aleksandr Gabrichevsky. This was a true meeting of minds based on profound mutual understanding and common basic notions of art (such as the ambiguous concept of 'classical art’. Because of the language barrier, Gabrichevsky and his works have remained little known to scholars who work in West-European languages. A disciple of Paul Frankl, during the 1920s he researched the problems of space and time in a broader theoretical and philosophical context at the GAKhN. His main work of the time, The Morphology of Art, demonstrates influences of Friedrich Schelling, Johann Wolfgang Goethe, Henri Bergson and, above all, Georg Simmel. This work could not have been completed nor published at the time. Its recent publication revealed the profound philosophical foundations of Gabrichevsky’s studies of architecture as well as of the project of publishing Renaissance architectural treatises that he organized.

  14. Review: Hannes Heer, Walter Manoschek, Alexander Pollak & Ruth Wodak (2008). The Discursive Construction of History. Remembering the Wehrmacht’s War of Annihilation

    OpenAIRE

    Rupnow, Dirk

    2008-01-01

    Die beiden Wehrmachtsausstellungen (1995/2001) sowie die mit ihnen verbundenen Debatten stellen ein wichtiges Kapitel der deutschen und österreichischen Auseinandersetzung mit den NS-Verbrechen dar. Sie haben nicht nur die Nachkriegslegende von der "sauberen Wehrmacht" nachhaltig infrage gestellt, sondern auch das Bild vom Charakter des Völkermords und der an ihm beteiligten Täter verändert. Ruth WODAK und ihr interdisziplinäres Team beleuchten sowohl die Verbrechen der Wehrmacht selbst wie a...

  15. Review: Hannes Heer, Walter Manoschek, Alexander Pollak & Ruth Wodak (2008. The Discursive Construction of History. Remembering the Wehrmacht's War of Annihilation

    Directory of Open Access Journals (Sweden)

    Dirk Rupnow

    2008-07-01

    Full Text Available The two Wehrmacht exhibitions (1995/2001 and the debates around them represent an important chapter in the history of how Germany and Austria have dealt with the Nazi past. They strongly challenge the postwar myth of an "untainted Wehrmacht" just as they changed the public perception of the Nazi genocide and its perpetrators. Ruth WODAK and her interdisciplinary team shed light on the Wehrmacht crimes during WWII as well as their subsequent reception and representation. The volume gives an excellent overview of this important part of the history and aftermath of the Holocaust. Its specific layout and structure can also serve as a paradigm for comparable studies. URN: urn:nbn:de:0114-fqs080378

  16. Infusion Nursing: An Evidence-Based Approach - Third edition Alexander Mary Infusion Nursing: An Evidence-Based Approach - Third edition 625pp Elsevier 9781416064107 1416064109 [Formula: see text].

    Science.gov (United States)

    2010-11-03

    This book considers all aspects of infusion therapy and provides a solid evidence base. Its 30 chapters are well organised into six sections covering physiological considerations, infusion therapies and nursing practice.

  17. Dispositivos, máquinas y principio-cine : La utopía intermediática de Alexander Kluge

    OpenAIRE

    Russo, Eduardo Adrián

    2011-01-01

    Realizador polimorfo, artista pensador, Kluge es difícilmente apresable por nuestras prácticas de percepción y catalogación usuales, que se empeñan en distinguir disciplinas, especialidades, zonas de destreza o de trabajo experto a veces no tanto por apego al rigor, sino por nuestra necesidad de rótulos. Más allá de sus sucesos cinematográficos tempranos en festivales cinematográficos de altísima repercusión como el de Venecia, donde obtuvo el León de Oro por Artistas bajo la carpa del circo:...

  18. Surface meteorological, biological, chemical, and physical oceanographic data collected ALEXANDER AGASSIZ and HORIZON in the South Pacific Ocean from 19670201 to 19681001 (NODC Accession 7000787)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data and information related to this accession are in an analog form only. Please contact Services.NODC@noaa.gov for additional information.

  19. Euroopa stabiilsusmehhanismi asutamislepingu artikli 4 lõike 4 kooskõla Eesti põhiseadusega / Illimar Pärnamägi, Age Inkinen, Alexander Lott

    Index Scriptorium Estoniae

    Pärnamägi, Illimar

    2012-01-01

    Artikkel põhineb Justiitsministeeriumi poolt Vabariigi Valitsuse nimel Riigikohtule esitatud arvamusel Euroopa stabiilsusmehhanismi asutamislepingu (ESMAL) artikli 4 lõike 4 põhiseaduspärasuse kohta. ESMAL artikli 4 lõike 4 õigusmõju välistamise võimalikkusest, põhiseaduspärasusest ja põhiseaduse printsiipide kaalumisest

  20. Süvendatud majandus- ja rahandusliidu rajamine: mõju põhiõiguste kaitsele ning põhiseaduse aluspõhimõtetele / Alexander Lott

    Index Scriptorium Estoniae

    Lott, Alexander, 1987-

    2013-01-01

    Euroopa Parlamendi ja nõukogu määruse ettepanekust ühtse solveerimismehhanismi ja pankade ühtse solveerimisfondi loomiseks. Kriisilahendusmehhanismi loomise ettepanekust süvendatud majandus- ja rahaliidu rajamise kontekstis, mõjust omandipõhiõiguse kaitsele ja määruse kooskõlast põhiseaduse aluspõhimõtetega

  1. Fluxgate gradiometry survey in the ruins of Karksi castle and palaeoenvironmental analysis in its hinterlands / Heiki Valk, Chantel Summerfield, Pluskowski, Alexander

    Index Scriptorium Estoniae

    Valk, Heiki, 1959-

    2009-01-01

    Gradiomeetriliste uuringute tulemused sobivad üldjoontes Karksi linnuse 17. sajandi plaaniga. Suurim erinevus ilmnes peavärava piirkonnas. Linnusest 5 km lõuna poolt võetud palünoloogiline analüüs näitab, varasematel metsamaastikel suureneb vahemikus 890-1040 pKr kanarbiku osakaal ja ilmuvad rukki õietolmuterad

  2. George Alexander Kennedy: Comparative Rhetoric: An Historical and Cross-cultural introduction. NewYork-Oxford: Oxford University Press, 1998. 238 strani (review

    Directory of Open Access Journals (Sweden)

    Nada Grošelj

    2002-12-01

    Full Text Available Po dolgoletnem ukvarjanju z retoriko v klasični in pozni antiki Zahoda obravnava George A. Kennedy, verjetno eden najbolj cenjenih živečih strokovnjakov za to vedo (njegovo delo Klasična retorika je na voljo tudi v slovenskem prevodu, tudi retoriko v drugih kulturah.

  3. The Peculiarities of Working with “The Tale of the Fisherman and the Fish” (Skazka o Rybake i Rybke by Alexander Pushkin on The Basis of its Folklore Source

    Directory of Open Access Journals (Sweden)

    E V Merkuryeva

    2011-12-01

    Full Text Available The article deals with a new methodological approach to the literary fairy tale of the first half of the XIX century in comparison with its folklore sources within the frame of its international fairy-tale plot at the lessons of Literary Reading at elementary school.

  4. Shoot winter injury and nut cold tolerance: Possible limitations for American chestnut restoration in cold environments? In: Sniezko, Richard A.; Yanchuk, Alvin D.; Kliejunas, John T.; Palmieri, Katharine M.; Alexander, Janice M.; Frankel, Susan J., tech

    Science.gov (United States)

    Thomas M. Saielli; Paul G. Schaberg; Gary J. Hawley; Joshua M. Halman; Kendra M. Gurney

    2012-01-01

    Approximately 100 years ago, American chestnut (Castanea dentata (Marsh.) Borkh.) was rapidly removed as an overstory tree by the fungal pathogen Cryphonectria parasitica (the causal agent of chestnut blight). Currently, the most effective method of restoration involves the hybridization of American chestnut with the...

  5. Pain: clinical manual for nursing practice Pain: clinical manual for nursing practice Margo McCaffery Alexander Beebe Mosby Yearbook UK £17.25 0 7234 1992 2.

    Science.gov (United States)

    1994-12-07

    The ultimate Bible on pain from two of the world's leading individuals in this field. Pain is a subjective experience suffered by every individual at some stage of life. This definitive text dearly and thoroughly explores an important area of nursing practice from many dimensions. The chapter on assessment alone is an invaluable tool for any nurse regardless of speciality.

  6. Adapt or Perish: Aeromedical Evacuation in the Contested Air Space of the Pacific Theater

    Science.gov (United States)

    2016-08-01

    55. Frank W. Walbank, Alexander the Great: King of Macedonia, Encyclopedia ... Britannica Online, (https://www.britannica.com/biography/Alexander-the-Great), (Accessed 7 July 2016). 56. Robert Burnham, Spanish Recruits in the

  7. Televiisorit kaissu ei võta, kuid raamatut küll : raamatupoe letilt võib leida mitte lihtsalt häid, vaid lausa suurepäraseid lasteraamatuid / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2001-01-01

    Sisu : Lloyd Alexander. Llyri loss; Lloyd Alexander. Rändur Taran; Skomantas. Teutoonide vang. Lühidalt ka Otfried Preussleri, Thorbjırn Egneri, Vitezlav Nezvali, Jỉi Trnka, Aino Perviku ja Ellen Niidu raamatutest

  8. Kasahstani presidendi väimees rajab Eestisse kuurorti / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2007-01-01

    Plaanist rajada Anija valda Pillapallu üle kuue miljardi krooni maksev puhkekompleks "The Mahuste Resort". Projekti valmistavad ette Eesti (projektijuht Märt Poots), Suurbritannia ja Iisraeli (projektijuht Alexander Goldman) firmad. Küsimustele vastab Alexander Goldman

  9. Consortia for Improving Medicine with Innovation and Technology (formerly known as Center for Integration of Medicine and Innovative Technology)

    Science.gov (United States)

    2015-12-01

    Accommodate Essential Tremor 2012 Out - 001711 12-1230 Award Closed Slocum , Alexander MIT 2.75 Design Class 2012 Out - 001733 Award Closed Slocum ...Alexander MIT 2.75 Design Class 2011 Out - 001647 Award Closed Slocum , Alexander MIT- CIMIT Precision Medical Devices Graduate Design Course 2.75 2014...Out - 001911 Fully Released Slocum , Alexander MIT-CIMIT Precision Medical Devices Graduate Design Course 2.75 2009 Out - 001097 Award Closed Slocum

  10. Regional Variation in Use of Complementary Health Approaches by U.S. Adults

    Science.gov (United States)

    ... hypnosis, homeopathy, massage, meditation (mantra, mindfulness, and spiritual), Alexander technique, Feldenkreis, Pilates, Trager psychophysical integration, naturopathy, progressive relaxation, ...

  11. Evolution of Transdniestrian Conflict in the Republic of Moldova: Prospects for Its Solution

    Science.gov (United States)

    2004-06-01

    in Chisinau in 1897, what constituted 32 The famous Russian poet Alexander Pushkin was one of the...Tsar Alexander I and Sultan Mahmud II. The Russians viewed this annexation as liberating the Bessarabian Christians from Ottoman repression, and at...143 Gheorghe Cojocaru, op. cit., 139. 144 The main figure in the military opposition was General Alexander Lebed’, Commander of the Fourteenth

  12. Educational Psychology's Past and Future Contributions to the Science of Learning, Science of Instruction, and Science of Assessment

    Science.gov (United States)

    Mayer, Richard E.

    2018-01-01

    Patricia Alexander (2018) provides a thought-provoking analysis of the past and future of educational psychology. Based on the themes in Alexander's paper, the present paper explores the past and future of educational psychology's contributions to: (a) the science of learning, corresponding to Alexander's theme of "a focus on learning as a…

  13. Karje Vana Maailma äärelt / Sven Vabar

    Index Scriptorium Estoniae

    Vabar, Sven

    2005-01-01

    IX Pimedate Ööde Filmifestivali filme - dokumentaalfilm Islandi muusikast "Karjuv meistriteos" ("Screaming Masterpiece") : režissöör Alexander Ergis : Island 2005, mängufilm "Otsides Alexander'it" ("Looking for Alexander") : režissöör Francis Leclerc : Kanada 2004

  14. Disease: H00065 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00065 Alexander disease Alexander disease is a rare, but often fatal neurological ...ult forms. The characteristic neuropathological feature of all forms of Alexander's disease is the presence ...y acidic protein (GFAP) and small stress proteins in astrocytes. Neurodegenerative disease GFAP; glial fibrillary acidic protein (mutation) [HSA:2670] [KO:K05640] thyrotropin releasing hormone [DR:D00176] Disease class: leukodystrophy Affected regtion: midbrain, cerebellum Microscopic lesion: Rosenthal fibers MeSH: D038261 OMIM: 203450 PMID:17498694 Quinlan RA, Brenner M, Goldman JE, Messing A. GFAP and its role in Alexander... R, Gibbon T, Prescott AR, Brenner M, Quinlan RA The Alexander disease-causing gl... M TRH therapy in a patient with juvenile Alexander disease. Brain Dev 28:663-7 (

  15. Book Reviews

    OpenAIRE

    Dieuwke Wendelaar Bonga; Elly Touwen-Bouwsma; Albert Hahl; Pim Schoorl; L. Smits; Jean Robert Opgenort; Janny de Jong; Hugo Klooster; Peter G. Riddell; Nico Kaptein; A.Th. Boone; C. de Jonge; Willemijn de Jong; Bernice de Jong Boers; Roy W. Hamilton

    1998-01-01

    - K. Alexander Adelaar, James T. Collins, Bibliografi dialek Melayu di pulau Sumatera. Kuala Lumpur: Dewan Bahasa dan Pustaka (Kementerian Pendidikan Malaysia), 1995, xliii + 201 pp. [Siri Monograf Bibliografi Sejarah Bahasa Melayu.] - K. Alexander Adelaar, James T. Collins, Bibliografi dialek Melayu di pulau Jawa, Bali dan Sri Lanka. Kuala Lumpur: Dewan Bahasa dan Pustaka (Kementerian Pendidikan Malaysia), 1995, xxxvii + 213 pp. [Siri Monograf Bibliografi Sejarah Bahasa Melayu.] - K. Alexand...

  16. Theoretical-Numerical Analysis of Boundary-Layer Stability with Combined Injection and Acoustic Absorptive Coating

    Science.gov (United States)

    2014-01-01

    Alexander V. Fedorov and Vitaly G. Soudakov Moscow Institute of Physics and Technology 9, Institutskii per. Dolgoprudny, Moscow Region, 141700 Russia...FA9550-12-D-0003 0002 5b. GRANT NUMBER CRDF 12-2044 5c. PROGRAM ELEMENT NUMBER 61102F 6. AUTHOR(S) Alexander V. Fedorov and Vitaly G. Soudakov...Alexander V. Fedorov and Vitaly G. Soudakov Moscow Institute of Physics and Technology Dolgoprudny, Moscow Region, Russia, 141700 January 2014

  17. Element Pattern of an Axial Dipole in a Cylindrical Phased Array. Part 1. Theory. Part 2. Element Design and Experiments. Volume 1

    Science.gov (United States)

    1986-10-01

    PART I: Theory; PART I/: Element Design and Experiments Boris Tomasic, Alexander Hessel and John C. Herper 1l~* . - APPROVED FOR PUBLIC RELEASE...Clausification) Element Pattern of an Axial Dipole (cont.) 61102F 2305 03 03 12. PERSONAL AUTHOR(S) Boris Tomasic, Alexander Hessel , and John C. Herper...the Electromagnetic Sciences Division, Rome Air De- velopment Center, Hanscom AFB, MA 01731. Alexander Hessel is with the Polytechnic University, Route

  18. 78 FR 21411 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Science.gov (United States)

    2013-04-10

    ... Dunavant Cotton Manufacturing Company, 109 E. Fleming Dr., Morganton, 13000227 Haywood County Francis Grist... River Grasslands MPS), Address Restricted, Alexander, 13000233 32MZ422, (Native American Occupation and...

  19. Karst Feature Inventory Points

    Data.gov (United States)

    Minnesota Department of Natural Resources — Southeastern Minnesota is part of the Upper Mississippi Valley Karst (Hedges and Alexander, 1985) that includes southwestern Wisconsin and northeastern Iowa. Karst...

  20. Ejercicio físico como tratamiento en el manejo de lumbalgia Exercise as a treatment for low back pain management

    National Research Council Canada - National Science Library

    Juan Diego Zamora Salas

    2017-01-01

    ...; the recommended exercise methods include exercises for the trunk and abdomen muscles mainly, muscular resistance, spinal stability, Pilates, Williams and Mckenzie exercises, Feldenkrais and Alexander...

  1. Constructing a Regional Order: Northeast Asia and the Systemic Constraints on Korean Unification

    National Research Council Canada - National Science Library

    Vance, Terence J

    2006-01-01

    .... Using a truly unique International Relations approach, this thesis explores the utility of Alexander Wendt's Social Theory of International Politics to address the evolving structure of Northeast...

  2. Body Awareness: a phenomenological inquiry into the common ground of mind-body therapies

    National Research Council Canada - National Science Library

    Mehling, Wolf E; Wrubel, Judith; Daubenmier, Jennifer J; Price, Cynthia J; Kerr, Catherine E; Silow, Theresa; Gopisetty, Viranjini; Stewart, Anita L

    2011-01-01

    ... Psychotherapy, Body Awareness Therapy, mindfulness based therapies/meditation, Feldenkrais, Alexander Method, Breath Therapy and others with reported benefits for a variety of health conditions...

  3. 77 FR 4881 - Commercial Driver's license (CDL) Standards; Rotel North American Tours, LLC; Application for...

    Science.gov (United States)

    2012-01-31

    ... Endres, Helmut Erbersdobler, Reinhard Freudenstein, Alexander Friedl, Peter Hess, Gerhard Kinateder, Hermann Lichtenauer, Karl Lippl, Horst Mahl, Franz Manzinger, Fabian Maurer, Rudolf Ramsl, Paul Schl gl...

  4. Handling Interpretation and Representation in Multilingual Research: A Meta-study of Pragmatic Issues Resulting from the Use of Multiple Languages in a Qualitative Information Systems Research Work

    National Research Council Canada - National Science Library

    Ilse Baumgartner

    2012-01-01

    ...., Temple & Edwards, 2002; Temple, Edwards & Alexander, 2006; Edwards, 1998; Temple & Young 2004). Methodological investigations going beyond pure translation dilemmas in qualitative research are, however, almost non-existent...

  5. Alexander Conze, “On the Origin of the Visual Arts”, Lecture held on July 30, 1896 [in the Royal Prussian Academy of Sciences]. Originally published as ‘Über den Ursprung der bildenden Kunst‘, Sitzungsberichte der Königlich Preußischen Akademie der Wissenschaften zu Berlin. Gesammtsitzung vom 11. Februar 1897, Berlin: Reichsdruckerei 1897, pp. 98-109.

    Directory of Open Access Journals (Sweden)

    Karl Johns (trans & ed.

    2012-12-01

    Full Text Available With the discoveries made by Schliemann, the increasing evidence from other cultures around the world and a subtle analysis as we have it in Riegl’s Stilfragen, one can now clearly see that the geometric style was not the earliest to thrive in Greece. The earliest impulses of art seem to have consisted in the attempt to capture the living image of an object or action ‘images precisely gathered in the memory’ (Joshua Reynolds, and not the urge to sit before something and make a picture of it. They had a common root in the language of sounds as ‘speech in terms of visible forms’. Together with the appeal of rhythm and symmetry this might well be inborn, but also included a technical aspect in which humanity differs from bees by further developing variations. Human and animal imagery did not arise in a naturalist vein but within the dictates of stylistic schemata with a linearity preventing plant forms and reminding us that landscape only arrived later. There was more than one source leading primitive art to geometric motifs.

  6. Alexander Conze, “Greek Relief Sculpture”. Originally published as ‘Über das Relief bei den Griechen’, Sitzungsberichte der Königlich Preussischen Akademie der Wissenschaften zu Berlin. Gesammtsitzung vom 25. Mai, 1882, no. 26, pp. 1-15 (pp. 563-577.

    Directory of Open Access Journals (Sweden)

    Karl Johns (trans & ed.

    2012-12-01

    Full Text Available On the basis of a corpus edition of Attic grave stelae, it becomes possible to make certain broad observations about the nature and development of Greek relief sculpture, a branch of the arts in which the Greeks are admitted to have excelled. Archaeology has added so much to our knowledge in the course of the 19th century that we can dismiss the earlier assumption that these sculptures did not have colour. In fact they were painted, and the evidence shows that in spite of its severe technical limitations, Greek relief sculpture developed in an increasingly painterly direction, in tandem with the development of Greek wall and panel painting as we know it – more so than vase painting. St. Remy and Pergamon provide examples of the prodigious Greek application of the genre, where ‘there were no innovations left for Roman art to make’.

  7. Instruction manual: common frame brushless synchronous motor-generator set : field failure and out-of-step protection assembly for sychronous motor : Kato KCR 360 voltage regulators : installation and maintenance of contactors type EG of different versions : AB DE-ION circuit breakers : CCGS Sir William Alexander

    National Research Council Canada - National Science Library

    Kato Engineering Inc

    1984-01-01

    Contents: Common frame brushless synchronous motor-generator set - Field failure and out-of-step protection assembly for sychronous motor - Kato KCR 360 voltage regulators - Installation and maintenance...

  8. Katilini Yaratan Annelik: Elif Şafak'ın "İskender" Adlı Romanından Yola Çıkarak Türkiye'de Kadınlık Ve Erkeklik Rollerine Dair Bir Sorgulama Motherhood Creating Its Killer: Based On Elif Shafak's Novel "Alexander" Questioning The Femininity And Masculinity In Turkey

    Directory of Open Access Journals (Sweden)

    İlknur MEŞE

    2013-03-01

    Full Text Available Elif Shafak‟s novel “Alexander” holds many references tofemininity and masculinity in the context of the „purity‟ of woman and„honor‟ of man, which still exist in Turkey. On the cover of the book, thewriter poses in man‟s suit which tells us that it is woman –especiallymothers- who prepares man to the appropriate masculinity. Theinequality between man and woman has been built culturally ratherthan a natural result created by biological differences. The concept ofmasculinity has been shaped by political, ideological, and marketorientedinterests. In this sense, masculinity gained hard meanings likemind, power, will, achievement, activity, committing violence, actingindependently, and knowing to rule the others. However, the concept offemininity - having the reverse situation- has soft meanings likecompassion, pity, conscience, peaceful, passivity, and sensuality.Woman has tried to negotiate her secondary position by aspiringthe power of man. In this sense, we can assess woman‟s wish for a malechild as a wish of legitimate power. Her wish of compensating herhelplessness with the power attributed to man has no benefit otherthan creating anothervictimhood. Femininity and its repercussionmotherhood are something produced down the generations. More orless each new generation has been affected by this legacy. Both menand women will be able to get over this power cycle by questioning thecultural system and using the capacity of their subjectivity. Elif Şafak‟ın “İskender” adlı romanı, Türkiye‟de halen varlığınısürdüren, kadının „namusu‟ ve erkeğin „şerefi‟ üzerinden kadınlık veerkeklik rolleri tanımlamalarına dair çok göndermeler bulabileceğimizbir eser. Yazarın, kitabın kapağında bir erkek takım elbisesi içindeverdiği pozun bize anlattığı şey, tıpkı romanın başkahramanı olanİskender gibi, erkekleri, kabullere uygun erkeklik rolüne hazırlayanlarınkadınlar -özellikle anneler- olduğu gerçeğidir. Kadın ve erkekarasındaki eşitsizlik, biyolojik farklılıkların yarattığı doğal bir sonuçolmaktan ziyade kültürel olarak inşa edilmiştir. Siyasi, ideolojik vepiyasaya yönelik çıkarlar doğrultusunda şekillenen erkeklik kavramı,akıl, güç, irade, başarı, aktiflik, şiddet uygulayabilmek, bağımsızdavranmak, başkalarını yönetmeyi bilmek gibi sert anlamlarkazanırken, kadınlık kavramı bunların tam aksi olarak, şefkat,merhamet, vicdan, barışçıl, pasiflik ve duygusallık gibi yufka anlamlarasahip olmuştur.Kadın, erkek karşısındaki ikincil konumunu, eşitlikçi bir ilişkilehine stratejiler üreterek aşmak yerine, erkeğin gücüne talip olaraködünlemeye çalışmıştır. Özellikle kırsal kesime ait bir özellik gibigörülmesinin aksine bütün bir kültürel sisteme hâkim olan kadınlarınerkek çocuk istemini meşru bir güç istemi olarak da okuyabiliriz. Kendiçaresiz konumunu erkeğe atfedilen güç ile ödünleme isteğinin, başkabir mağduriyet yaratması dışında bir faydası yoktur. Bunun travmatiksonuçlarını romanda, erkek çocuk doğuramadı diye kendi bedenindenonu ölüme sürükleyerek öç alan bir kadın ile kendi yarattığı erkeğinmaktulü olan başka bir kadında görebiliriz. Bu iki kadın anne-kızdır.Kadınlık ve onun izdüşümü olan annelik kuşaklar boyu üretilen bir şeyolarak her yeni nesli, dışına çıkmaya çalışsa da bir miktaretkilemektedir. Hem kadınları hem de erkekleri bu iktidar döngüsüiçinden çıkaracak şey, rollerin dayatmalarının farkına vararak kültürelsistemi sorgulamaları ve öznelik kapasitelerini işletmeleri olacaktır.

  9. 76 FR 10587 - Product Cancellation Order for Certain Pesticide Registrations

    Science.gov (United States)

    2011-02-25

    ...-02391 Ortho Dormant Calcium polysulfide Disease Control. 000264-01001 Scout Manufacturing Tralomethrin.... 264 Bayer CropScience LP, 2 T.W. Alexander Drive, P.O. Box 12014, Research Triangle Park, NC 27709. 432 Bayer Environmental Science, 2 T.W. Alexander Drive, P.O. Box 12014, Research Triangle Park, NC...

  10. 75 FR 26969 - National Institute on Aging; Notice of Closed Meetings

    Science.gov (United States)

    2010-05-13

    ... of Alzheimer's Disease. ] Date: June 18, 2010. Time: 12 p.m. to 4:30 p.m. Agenda: To review and..., Suite 2C212, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Alexander Parsadanian, PhD... Conference Call). Contact Person: Alexander Parsadanian, PhD, Scientific Review Officer, National Institute...

  11. 77 FR 26770 - National Institute on Aging; Notice of Closed Meetings

    Science.gov (United States)

    2012-05-07

    ... Committee: National Institute on Aging Special Emphasis Panel; Presenilin and Alzheimer's Disease. Date.... (Telephone Conference Call). Contact Person: Alexander Parsadanian, Ph.D., Scientific Review Officer..., Suite 2C212, Bethesda, MD 20892. (Telephone Conference Call). Contact Person: Alexander Parsadanian, Ph...

  12. 78 FR 26643 - National Institute of Environmental Health Sciences; Notice of Meeting

    Science.gov (United States)

    2013-05-07

    .... Agenda: An overview of the Chronic Disease Epidemiology Group, Molecular & Genetic Epidemiology Group and..., Rodbell Auditorium, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Closed: June 03, 2013, 11.... Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T. W. Alexander Drive...

  13. The Grand Strategy of the Soviet Union

    Science.gov (United States)

    1982-03-25

    and Peter the Great, Alexander Nevskii and Alexander I were powerful but dangerous allies for Stalin a.J the Party. These names and all that went...of sheer numberical advantage, and how reluctantly they recognize the virtues of Russian military thought. And yet before there was a Pushkin to be

  14. RESENSIES / REVIEWS

    African Journals Online (AJOL)

    6 Apr 2016 ... 222 Brandwaterkom (Alexander Strachan)—H. P. van Coller ... Alexander Strachan. The recently published and prizewinning novel Brandwaterkom is vintage Strachan with an intricate structure, imbedded stories ...... Henning 'n irriterende studentikose Afrikaans gebruik wat deurspek is met Engels.

  15. Opfindelsen af naturen

    DEFF Research Database (Denmark)

    Thomsen, Torsten Bøgh

    2016-01-01

    Kritisk omtale og kontekstualisering af Andrea Wulfs, "The Invention of Nature: Alexander von Humboldt’s New World". Der er en direkte forbindelse imellem oplysningstidens naturforståelse og den nuværende klimakrisevirkelighed. Alexander von Humboldt opfandt ikke bare naturen, han påpegede også det...

  16. Vengeance without Justice, Injustice without Retribution: The Afro-American Council's Struggle against Racial Violence

    Science.gov (United States)

    Alexander, Shawn Leigh

    2007-01-01

    On January 19, 1901, just one week after Leavenworth, Kansas, witnessed the burning of Fred Alexander, a twenty-two-year-old black Spanish-American war veteran, the "Wichita Searchlight" called for armed self-defense. The brutal murder of Alexander horrified many African Americans throughout the region, who decided that it was time to…

  17. Detection of the CS20 Colonization Factor Antigen in Diffuse-Adhering Escherichia coli Strains

    Science.gov (United States)

    2010-01-01

    Savarino5 & Claudio F. Lanata4•7 ’Institute de Medicina Tropical ’Alexander von Humboldt’, Universidad Peruana Cayetano Heredia, Lima, Peru; 2Umvers1ty...de C•encias Aplicadas. Lima, Peru Abstract Correspondence: Theresa J. Ochoa, Institute de Medicina Tropical ’Alexander von Humboldt’, Universidad

  18. Multifunction laser systems in clinical and resort practice

    OpenAIRE

    Zabulonov, Yuriy; Vladimirov, Alexander; Chukhraiev, Nikolay; Elmehsenawi, Yousry; Zukow, Walery

    2016-01-01

    SHUPYKNATIONALMEDICALACADEMY OF POSTGRADUATE EDUCATION UKRAINIANSOCIETY OFPHYSICAL AND REHABILITATION MEDICINE RADOM UNIVERSITY       Yuriy Zabulonov, Alexander Vladimirov, Nikolay Chukhraiev, Yousry Elmehsenawi, Walery Zukow       MULTIFUNCTION LASER SYSTEMS IN CLINICAL AND RESORT PRACTICE   Edited by Yuriy Zabulonov, Alexander Vladimirov, Nikolay Chukhraiev, Yousry Elmehsenawi, Walery Zukow  ...

  19. 76 FR 66361 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Science.gov (United States)

    2011-10-26

    ... BERNARD STEVEN JACQUES BERTSCHI HANSPETER ANDREA BINER ALFRED ALEXANDER P BIRDWELL NATALIE ] BLANK JASON... KONG SUIT CHO ALEXANDER HAN CHOI SUN YOUNG CHOONG CAROLINE VICTORIA CHOU PATRICK JAMES CHOU TOM CHI-KWAN CHRISTENSON DEBORAH CHRISTENSON STEPHEN V CHUA CHOON MUI CHUA KEVIN WEI QIANG CHUNG JUDY CLUBB...

  20. Blended Learning: The Army’s Future in Education, Training, and Development

    Science.gov (United States)

    2011-03-24

    Ronald Heifetz , Alexander Grashow, and Marty Linsky, The Practice of Adaptive Leadership; Tools and Tactics for Changing Your Organization and the...work process and possess an “if it is not broke do not fix it” mentality.71 Furthermore, Ron Heifetz , Alexander Grashow, and Marty Linsky, assert that