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Sample records for huskey amy bowen

  1. Use of Bowen Theory.

    Science.gov (United States)

    Gibson, Joan M.; Donigian, Jeremiah

    1993-01-01

    Notes that theory-based approach to treatment of codependency is missing in fields of chemical dependency and mental health. Presents Bowen family systems therapy as foundation and framework for treatment goals and interventions. Illustrates similarities between characteristics of low levels of differentiation of self and codependency. (Author/NB)

  2. Use of Bowen Theory.

    Science.gov (United States)

    Gibson, Joan M.; Donigian, Jeremiah

    1993-01-01

    Notes that theory-based approach to treatment of codependency is missing in fields of chemical dependency and mental health. Presents Bowen family systems therapy as foundation and framework for treatment goals and interventions. Illustrates similarities between characteristics of low levels of differentiation of self and codependency. (Author/NB)

  3. Amy Lum Fern

    Science.gov (United States)

    Rossi, Joe

    2007-01-01

    This article presents an interview with Amy Lum Fern, Hawai'i Department of Education teacher from 1933 to 1972. Amy Lum Fern was born in Honolulu in 1909. She received her early education at Central Grammar School and later attended McKinley High School. After graduating from McKinley in 1928, she entered the University of Hawai'i, where she…

  4. A case of pigmented Bowen's disease*

    Science.gov (United States)

    Vivan, Márcia Maria; Hirata, Sérgio Henrique; do Nascimento, Liliane Santos; Enokihara, Milvia Maria Simões e Silva

    2017-01-01

    Pigmented Bowen's disease is a rare subtype of Bowen's disease. Clinically it presents as a slow-growing, well-defined, hyperpigmented plaque, and should be included as a differential diagnosis of other pigmented lesions. The authors describe a challenging case of pigmented Bowen's disease with non-diagnostic dermscopy findings. PMID:28225972

  5. AMY trigger system

    Energy Technology Data Exchange (ETDEWEB)

    Sakai, Yoshihide [National Laboratory for High Energy Physics, Tsukuba, Ibaraki (Japan)

    1989-04-01

    A trigger system of the AMY detector at TRISTAN e{sup +}e{sup -} collider is described briefly. The system uses simple track segment and shower cluster counting scheme to classify events to be triggered. It has been operating successfully since 1987.

  6. Kingsley Amis: The Prescriptivist

    Directory of Open Access Journals (Sweden)

    Cehan Nadina

    2016-12-01

    Full Text Available In The King’s English: A Guide to Modern Usage, Kingsley Amis identified H. W. Fowler as his great predecessor. Amis revealed himself as a soldier in the army of prescriptivists, voices that settle ‘modern linguistic problems’ while proudly parading as non-linguists. The book exposed Amis’s acrimonious dispute with descriptive linguists, while the writer delivered his very own brand of linguistics to his readers. This paper looks at the success of Amis’s book and its similarities with Fowler’s. It also emphasizes the continuity and popularity of usage handbooks while presenting some of their chief characteristics as exemplified by Amis’s work.

  7. Amy Courtney: Freewheelin' Farm

    OpenAIRE

    Rabkin, Sarah

    2010-01-01

    Shareholders in Freewheelin’ Farm’s community supported agriculture program enjoy an unusual perk: delivery by bicycle-drawn trailer. Freewheelin’ founder Amy Courtney, a 1997 graduate of UCSC’s Apprenticeship in Ecological Horticulture, strives to produce fresh, healthy food while minimizing her environmental footprint. Courtney started the farm in 2002 with almost no motorized vehicles, incorporating used equipment and recycled materials wherever possible in the farm’s operations. She and h...

  8. Ami - The chemist's amanuensis

    Directory of Open Access Journals (Sweden)

    Brooks Brian J

    2011-10-01

    Full Text Available Abstract The Ami project was a six month Rapid Innovation project sponsored by JISC to explore the Virtual Research Environment space. The project brainstormed with chemists and decided to investigate ways to facilitate monitoring and collection of experimental data. A frequently encountered use-case was identified of how the chemist reaches the end of an experiment, but finds an unexpected result. The ability to replay events can significantly help make sense of how things progressed. The project therefore concentrated on collecting a variety of dimensions of ancillary data - data that would not normally be collected due to practicality constraints. There were three main areas of investigation: 1 Development of a monitoring tool using infrared and ultrasonic sensors; 2 Time-lapse motion video capture (for example, videoing 5 seconds in every 60; and 3 Activity-driven video monitoring of the fume cupboard environs. The Ami client application was developed to control these separate logging functions. The application builds up a timeline of the events in the experiment and around the fume cupboard. The videos and data logs can then be reviewed after the experiment in order to help the chemist determine the exact timings and conditions used. The project experimented with ways in which a Microsoft Kinect could be used in a laboratory setting. Investigations suggest that it would not be an ideal device for controlling a mouse, but it shows promise for usages such as manipulating virtual molecules.

  9. Connecting Bowen theory with its human origins.

    Science.gov (United States)

    Innes, M

    1996-12-01

    Murray Bowen recognized the importance of grounding clinical practice within a clearly articulated theoretical framework, which could claim its place within the general scientific tradition. Bowen theory has established itself as a significant contribution to the field of family therapy. However, in its insistence on excluding, in the interests of rigorous inquiry, all contributions except those from a natural science perspective, Bowen theory has neglected the very elements that are the identifying characteristics of Homo sapiens. As well as recognizing the common systemic characteristics of all life forms, a theory of the family and family therapy that does justice to the human condition will also need to attend to the ways in which human systems are distinct from those of other life forms. In this enterprise, the social sciences will be as important as the natural sciences.

  10. Determination of Surface Fluxes Using a Bowen Ratio System

    African Journals Online (AJOL)

    USER

    Physics Department, University of Ghana, Legon, Ghana ... The Bowen ratio was measured as the ratio of air temperature and vapour ..... appear greater than sensible heat flux imply that Bowen ratio is low and, hence, there is water available.

  11. An application of Bowen family systems theory.

    Science.gov (United States)

    Haefner, Judy

    2014-11-01

    While nurse practitioners initially work with the identified patient, Murray Bowen maintains it is the reciprocal functioning of all the members of the family which contributes to the emotional intensity of the patient. The emotional symptoms of an individual are an expression of the emotional symptoms of the family, which are often embedded in patterns of behaviors from past generations. The purpose of this paper is to facilitate understanding Bowen's theoretical concepts of family systems theory and apply these concepts to a family in therapy.

  12. Bowen disease – clinic, dermoscopy, patology

    Directory of Open Access Journals (Sweden)

    Poklękowska Katarzyna

    2011-07-01

    Full Text Available Bowen Disease is squamous cell carcinoma in situ in which the basement membrane is intact on histopathology. Lesions are usually solitary but may be multiple in 10-20 percent of cases. It typically presents as an erythematous enlarging plaque having irregular borders with scaling and crusting. The lesions may be fissured or verrucous or, rarely, pigmented. Ulceration may occur and is often a sign that invasive disease is developing. The risk of progression of Bowen disease to invasive carcinoma is about 3%. Bowen disease is most commonly found in patients over 60 years old. Oher risk factors: include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV- 16, 18, 34 i 48 infection.The majority of cases of Bowen disease revealed a peculiar dermoscopic pattern characterized by glomerular vesselsProliferation of numerous atypical keratinocytes throughout the entire thickness of the epidermis with hyperkeratosis, mitotic figures, multinucleated cells and dyskeratotic cells, full thickness dysplasia of the squamous epithelum, disorderly maturation of the epidermis, parakeratosis and loss of granular layer.

  13. The aliphatic amidase AmiE is involved in regulation of Pseudomonas aeruginosa virulence

    Science.gov (United States)

    Clamens, Thomas; Rosay, Thibaut; Crépin, Alexandre; Grandjean, Teddy; Kentache, Takfarinas; Hardouin, Julie; Bortolotti, Perrine; Neidig, Anke; Mooij, Marlies; Hillion, Mélanie; Vieillard, Julien; Cosette, Pascal; Overhage, Joerg; O’Gara, Fergal; Bouffartigues, Emeline; Dufour, Alain; Chevalier, Sylvie; Guery, Benoit; Cornelis, Pierre; Feuilloley, Marc G. J.; Lesouhaitier, Olivier

    2017-01-01

    We have previously shown that the eukaryotic C-type natriuretic peptide hormone (CNP) regulates Pseudomonas aeruginosa virulence and biofilm formation after binding on the AmiC sensor, triggering the amiE transcription. Herein, the involvement of the aliphatic amidase AmiE in P. aeruginosa virulence regulation has been investigated. The proteome analysis of an AmiE over-producing strain (AmiE+) revealed an expression change for 138 proteins, including some that are involved in motility, synthesis of quorum sensing compounds and virulence regulation. We observed that the AmiE+ strain produced less biofilm compared to the wild type, and over-produced rhamnolipids. In the same line, AmiE is involved in P. aeruginosa motilities (swarming and twitching) and production of the quorum sensing molecules N-acyl homoserine lactones and Pseudomonas Quinolone Signal (PQS). We observed that AmiE overproduction reduced levels of HCN and pyocyanin causing a decreased virulence in different hosts (i.e. Dictyostelium discoideum and Caenorhabditis elegans). This phenotype was further confirmed in a mouse model of acute lung infection, in which AmiE overproduction resulted in an almost fully virulence decrease. Taken together, our data suggest that, in addition to its role in bacterial secondary metabolism, AmiE is involved in P. aeruginosa virulence regulation by modulating pilus synthesis and cell-to-cell communication. PMID:28117457

  14. Codependency: another name for Bowen's undifferentiated self.

    Science.gov (United States)

    Fagan-Pryor, E C; Haber, L C

    1992-01-01

    Codependency is a term used to describe personality characteristics of people involved in unhealthy relationships. The authors purport that characteristics of codependency can be organized and interpreted using concepts from Bowen's family systems theory. Having such a framework addresses the criticisms that the concept of codependency lacks a solid theoretical foundation. In addition, nurses need to understand the concept if they are to evaluate their own actions regarding codependent behaviors.

  15. Benefits and limitations of Bowen therapy with psychiatric inpatients.

    Science.gov (United States)

    Zerbe, K J; Fabacher, J E

    1989-11-01

    The authors discuss the benefits and limitations of Bowen family systems therapy for psychiatric inpatients. Although this method may enable some patients to deal more effectively with crucial problems in their families of origins, its application for psychiatric inpatients has met with varying results. The authors discuss why hospitalized patients may have particular difficulties using Bowen therapy. The assumptions of Bowen theory are reviewed and critiqued in the context of the special problems encountered when working in a psychiatric hospital system.

  16. Is Bowen theory valid? A review of basic research.

    Science.gov (United States)

    Miller, Richard B; Anderson, Shayne; Keala, Davelyne Kaulana

    2004-10-01

    In the last 15 years, a substantial number of studies have tested the theoretical validity of Bowen family systems theory. A review of this basic research provided empirical support for the relationship between differentiation and chronic anxiety, marital satisfaction, and psychological distress. Bowen's assumption that couples with the same level of differentiation marry was not supported. His specific theories of sibling position and triangulation also received little empirical support. Research on multigenerational transmission has generally ignored Bowen's theoretical perspective, and more research needs to test Bowen's claim that his theory is universal. In addition, researchers still need to examine the effect of differentiation on child functioning, physical health problems, and adaptability.

  17. La enfermedad de Bowen en el ojo

    OpenAIRE

    Natteri R., Américo; Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú

    2014-01-01

    En 1942, McGavic, del Instituto de Oftamología del Presbiterian Hospital, publicó cinco casos de tumores que afectaban el área conjuntivo-corneol y que por sus características histológicas eran similares a la entidad que, en 1912, describiera Bowen en la piel como Dermatosis Pre-cancerosa, con el título de "Un estudio de dos casos da Proliferación Epitelial Atípica". In 1942, McGavic, Institute of Ophthalmology of Presbyterian Hospital, published five cases of tumors affecting the connecti...

  18. Energy Balance Bowen Ratio (EBBR) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Cook, D. R. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-01-01

    The Energy Balance Bowen Ratio (EBBR) system produces 30-minute estimates of the vertical fluxes of sensible and latent heat at the local surface. Flux estimates are calculated from observations of net radiation, soil surface heat flux, and the vertical gradients of temperature and relative humidity (RH). Meteorological data collected by the EBBR are used to calculate bulk aerodynamic fluxes, which are used in the Bulk Aerodynamic Technique (BA) EBBR value-added product (VAP) to replace sunrise and sunset spikes in the flux data. A unique aspect of the system is the automatic exchange mechanism (AEM), which helps to reduce errors from instrument offset drift.

  19. Energy Balance Bowen Ratio Station (EBBR) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Cook, DR

    2011-02-23

    The energy balance Bowen ratio (EBBR) system produces 30-minute estimates of the vertical fluxes of sensible and latent heat at the local surface. Flux estimates are calculated from observations of net radiation, soil surface heat flux, and the vertical gradients of temperature and relative humidity (RH). Meteorological data collected by the EBBR are used to calculate bulk aerodynamic fluxes, which are used in the Bulk Aerodynamic Technique (BA) EBBR value-added product (VAP) to replace sunrise and sunset spikes in the flux data. A unique aspect of the system is the automatic exchange mechanism (AEM), which helps to reduce errors from instrument offset drift.

  20. Distribution of Bowen ratio over the north Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    Rao, G.R.L.; Rao, M.V.; Prasad, P.H.; Reddy, K.G.

    The monthly averages of Bowen ratio over the north Indian Ocean have been computed Three typical situations in the months of January May and September are taken for the present study Month to month differences in the Bowen ratio over the study...

  1. The Female Voice: Applications to Bowen's Family Systems Theory.

    Science.gov (United States)

    Knudson-Martin, Carmen

    1994-01-01

    Responds to calls from feminist scholars to address potential biases against women in theories of family therapy. Summarizes findings from studies of female development and integrates findings into expanded model of Bowen's family systems theory. Includes case example comparing expanded model with traditional application of Bowen's theory.…

  2. AMiBA, XMM, and Cluster Surveys

    CERN Document Server

    Liang, H

    2001-01-01

    The Array for Microwave Background Anisotropy (AMiBA) is an interferometric array of 19 dishes co-mounted on a steerable platform and operating at 95GHz. One of the main scientific aims of AMiBA is to conduct cluster surveys using the Sunyaev-Zel'dovich (SZ) effect. Here we explore the potential of AMiBA as a tailor-made SZ instrument for the study of cluster physics and cosmology via cluster surveys out to the epoch of cluster formation. In particular, we explore the potential of combining AMiBA cluster surveys with the XMM-LSS (Large Scale Structure) survey.

  3. Elizabeth Bowen, Modernism, and the Spectre of Anglo-Ireland

    Directory of Open Access Journals (Sweden)

    James F. Wurtz

    2010-03-01

    Full Text Available The recent scholarly focus on Elizabeth Bowen’s modernism tends to reinforce a false dichotomy between Bowen as an Ascendancy Big House novelist and Bowen as a literary modernist. In keeping with Jameson’s argument that the colonial experience is at the root of Western modernism, I propose that her representations of Anglo-Irish Big House culture, in The Last September in particular, are in fact focal points for understanding Bowen as a modernist, and I argue that the Gothic, with its unavoidable political and colonial resonances, is fundamental to Bowen’s Irish modernism.

  4. Library Automation in Nigeria: The Bowen University Library ...

    African Journals Online (AJOL)

    The paper shares Bowen University Library, Iwo, Nigeria automation experiences using Open Source Library Management Software, Koha. ... settle the issue of regular power supply with management before embarking on automation project.

  5. A Case of Hidroacanthoma Simplex Mimicking Bowen s Disease

    Directory of Open Access Journals (Sweden)

    Pinar Ozuguz

    2013-10-01

    Full Text Available Hidroacanthoma simplex is a rare benign tumor that originates from eccrine sweet gland ducts. The lesions are characterized by slowly-growing, flat or slightly elevated, skin-colored, brown or erythematous, verrucous papules or plaques. Clinically, plaques may resemble seborrheic keratosis, basal cell carcinoma and Bowen%u2019s disease. Here, we present a case of atypically localized hidroacanthoma simplex mimicking Bowen%u2019s disease.

  6. Dermoscopy Clues in Pigmented Bowen's Disease

    Directory of Open Access Journals (Sweden)

    Daniela Gutiérrez-Mendoza

    2010-01-01

    Full Text Available Pigmented tumors have similar clinical features that overlap and hamper diagnosis. Dermoscopy increases the diagnostic accuracy of doubtful melanocytic lesions and has been used as a noninvasive tool in the detection of pigmented lesions (PLs like melanoma, basal cell carcinoma, and pigmented Bowen's disease (pBD. Our objective was to show the dermoscopic features of 2 cases of pBD and compare with the findings reported in the literature. Two dermoscopic images of biopsy proven pBD were retrospectively analyzed for dermoscopic patterns. Both cases showed brown regular globules, structureless brown and blue pigmentation, glomerular vessels, hypopigmented regression-like areas, and keratosis. These findings were similar to the cases reported previously. The dermoscopic diagnosis of pBD is based on the absence of criteria for a melanocytic lesion in the presence of glomerular vessels, regular brown globules and keratosis. Although pBD is rare, it should be included in the differential diagnosis of PLs, especially melanoma.

  7. Eccrine porocarcinoma arising within an area of Bowen disease.

    LENUS (Irish Health Repository)

    Lowney, A C

    2012-03-01

    Summary Very little is known about the aetiology of eccrine porocarcinoma (EP), a rare malignant sweat-gland tumour. Most reported cases have arisen de novo, or from a benign eccrine poroma. We report an unusual case, in which eccrine porocarcinoma arose at the exact site of pre-existing Bowen disease (BD).

  8. Periungual Bowen's disease successfully treated with photodynamic therapy.

    NARCIS (Netherlands)

    Zink, B.S.; Valente, L.; Ortiz, B.; Caldas, A.; Jeunon, T.; Marques-da-Costa, J.

    2013-01-01

    Bowen's disease or squamous cell carcinoma in situ is a malignancy of the skin confined to the epidermis that unusually involves the nail apparatus. The ideal treatment should complete clear the tumor, with preservation of the cosmetics and the function of the finger, which can be very difficult to

  9. Periungual Bowen's disease successfully treated with photodynamic therapy.

    NARCIS (Netherlands)

    Zink, B.S.; Valente, L.; Ortiz, B.; Caldas, A.; Jeunon, T.; Marques-da-Costa, J.

    2013-01-01

    Bowen's disease or squamous cell carcinoma in situ is a malignancy of the skin confined to the epidermis that unusually involves the nail apparatus. The ideal treatment should complete clear the tumor, with preservation of the cosmetics and the function of the finger, which can be very difficult to

  10. All in the family: a belated response to Knudson-Martin's feminist revision of Bowen theory.

    Science.gov (United States)

    Horne, K Blake; Hicks, Mary W

    2002-01-01

    The first formal attempt at revising Bowen theory within the marriage and family therapy literature is represented in the work of Knudson-Martin (1994). Claiming that several of the theory's concepts are defined at odds with female development, Knudson-Martin (1994) reconceptualizes and expands Bowen theory to rectify these perceived shortcomings. In turn, we address several fundamental concerns with Knudson-Martin's critique and revision of Bowen theory. An alternative representation of Bowen Theory, as well as its relationship to feminist thought, is put forth. Suggestions for the field's future relationship to Bowen theory are also discussed.

  11. AMY2A — EDRN Public Portal

    Science.gov (United States)

    AMY2A, a secreted protein, is an amylase isoenzyme produced by the pancreas. Amylases hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas.

  12. A Tall Tale: Laura Amy Schlitz

    Science.gov (United States)

    Gallagher, Mary Grace

    2008-01-01

    In this article, American author, children's librarian, and storyteller Laura Amy Schlitz is profiled. Schlitz is the winner of this year's Newbery Medal for her tall tale about the Mongols called "Gulnara the Tartar Warrior." Like her award-winning book, "Good Masters! Sweet Ladies!" (Candlewick, 2007), the tale takes place in the Middle Ages.…

  13. Obituary: George Hamilton Bowen Jr. (1925-2009)

    Science.gov (United States)

    Willson, Lee Anne; Struck, Curtis

    2011-12-01

    Our colleague and collaborator George Hamilton Bowen, Jr., passed away November 1, 2009 in Ames, Iowa. George was born June 20, 1925 in Tulsa, Oklahoma to George and Dorothy (Huntington) Bowen. He married Marjorie Brown June 19, 1948 in Redondo Beach, California; they had five children, with eight grandchildren and five great-grandchildren at the time of his death. George H. Bowen's third or perhaps his fourth career was in astronomy. He was drafted into the navy in 1944, at the end of his first year as a student at Caltech, and ended his war-time service as an electronic technician on the aircraft carrier Shangri-La. He later said "In just nine months, starting from scratch (Ohm's law!), we learned an amazing amount - not by memorization, of course, but by study and real understanding of the basic function of the most advanced AC circuits then being used for instrumentation, measurements, communications, control systems, and much more." He gained a confidence that he could quickly and accurately diagnose and solve technical problems that stood him well in future work. One accomplishment he took particular pride in was figuring out how the radar control used cams and gears to solve the trigonometry for accurate pointing. He also described how the captain was alarmed when weather conditions changed so that refraction no longer showed them distant, small boats around the curvature of Earth. After the war, George Bowen returned to undergraduate and eventually graduate study at Caltech, where he was recruited to the biophysics research group headed by future Nobel Laureate Max Delbrück. George often described his joy in working with these first-rate scientists and finding himself accepted as a part of the effort. He finished his BS with honors in 1949 and his PhD in 1953 with a thesis on "Kinetic Studies on the Mechanism of Photoreactivation of Bacteriophase T2 Inactivated by Ultraviolet Light" involving work with E Coli. This work was supported by grants from the U

  14. Spectrophotometry of Bowen resonance fluorescence lines in three planetary nebulae

    Science.gov (United States)

    O'Dell, C. R.; Miller, Christopher O.

    1992-01-01

    The results are presented of a uniquely complete, carefully reduced set of observations of the O III Bowen fluorescence lines in the planetary nebulae NGC 6210, NGC 7027, and NGC 7662. A detailed comparison with the predictions of radiative excitation verify that some secondary lines are enhanced by selective population by the charge exchange mechanism involving O IV. Charge exchange is most important in NGC 6210, which is of significantly lower ionization than the other nebulae. In addition to the principal Bowen lines arising from Ly-alpha pumping of the O III O1 line, lines arising from pumping of the O3 line are also observed. Comparison of lines produced by O1 and O3 with the theoretical predictions of Neufeld indicate poor agreement; comparison with the theoretical predictions of Harrington show agreement with NGC 7027 and NGC 7662.

  15. Doença de Bowen : perspectivas globais e actuais

    OpenAIRE

    Santos, Luís Miguel da Graça dos

    2014-01-01

    Trabalho final de mestrado integrado em Medicina (Dermatologia), apresentada á Faculdade de Medicina da Universidade de Coimbra Introdução: A Doença de Bowen (DB) é um carcinoma espinho-celular (CEC) in situ, que afecta frequentemente idosos (áreas expostas à radiação solar) e imunodeprimidos, e que tem um risco de até 10% de evolução para CEC invasivo. Por isso, estas lesões devem ser identificadas e tratadas precocemente. Objectivos: Avaliar a evidência disponível de modo a proceder a...

  16. AmiGO: online access to ontology and annotation data

    Energy Technology Data Exchange (ETDEWEB)

    Carbon, Seth; Ireland, Amelia; Mungall, Christopher J.; Shu, ShengQiang; Marshall, Brad; Lewis, Suzanna

    2009-01-15

    AmiGO is a web application that allows users to query, browse, and visualize ontologies and related gene product annotation (association) data. AmiGO can be used online at the Gene Ontology (GO) website to access the data provided by the GO Consortium; it can also be downloaded and installed to browse local ontologies and annotations. AmiGO is free open source software developed and maintained by the GO Consortium.

  17. AmiGO: online access to ontology and annotation data

    Energy Technology Data Exchange (ETDEWEB)

    Carbon, Seth; Ireland, Amelia; Mungall, Christopher J.; Shu, ShengQiang; Marshall, Brad; Lewis, Suzanna

    2009-01-15

    AmiGO is a web application that allows users to query, browse, and visualize ontologies and related gene product annotation (association) data. AmiGO can be used online at the Gene Ontology (GO) website to access the data provided by the GO Consortium; it can also be downloaded and installed to browse local ontologies and annotations. AmiGO is free open source software developed and maintained by the GO Consortium.

  18. A dermatoglyphic study of the Amis aboriginal population of Taiwan

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Amis is the largest aboriginal population in Taiwan. The previous dermatoglyphic studies of the Amis only reported limited data. In this study, we collected and analyzed the dermatoglyphs of 200 Amis in-dividuals, and we reported a wide range of dermatoglyphic variables including total finger ridge count, a-b ridge count, atd angle, axial triradius percent distance, and frequencies of fingerprint pattern, pal-mar thenar pattern, palmar interdigital pattern, and simian line. This study is the first comprehensive dermatoglyphic research of Amis since 1960s, and its dermatoglyphic data will be useful for future re-search in anthropology, genetics and medicine.

  19. A dermatoglyphic study of the Amis aboriginal population of Taiwan

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Amis is the largest aboriginal population in Taiwan. The previous dermatoglyphic studies of the Amis only reported limited data. In this study, we collected and analyzed the dermatoglyphs of 200 Amis individuals, and we reported a wide range of dermatoglyphic variables including total finger ridge count, a-b ridge count, atd angle, axial triradius percent distance, and frequencies of fingerprint pattern, palmar thenar pattern, palmar interdigital pattern, and simian line. This study is the first comprehensive dermatoglyphic research of Amis since 1960s, and its dermatoglyphic data will be useful for future research in anthropology, genetics and medicine.

  20. Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study.

    Science.gov (United States)

    Dodson, John A; Geda, Mary; Krumholz, Harlan M; Lorenze, Nancy; Murphy, Terrence E; Allore, Heather G; Charpentier, Peter; Tsang, Sui W; Acampora, Denise; Tinetti, Mary E; Gill, Thomas M; Chaudhry, Sarwat I

    2014-11-05

    While older adults (age 75 and over) represent a large and growing proportion of patients with acute myocardial infarction (AMI), they have traditionally been under-represented in cardiovascular studies. Although chronological age confers an increased risk for adverse outcomes, our current understanding of the heterogeneity of this risk is limited. The Comprehensive Evaluation of Risk Factors in Older Patients with AMI (SILVER-AMI) study was designed to address this gap in knowledge by evaluating risk factors (including geriatric impairments, such as muscle weakness and cognitive impairments) for hospital readmission, mortality, and health status decline among older adults hospitalized for AMI. SILVER-AMI is a prospective cohort study that is enrolling 3000 older adults hospitalized for AMI from a recruitment network of approximately 70 community and academic hospitals across the United States. Participants undergo a comprehensive in-hospital assessment that includes clinical characteristics, geriatric impairments, and health status measures. Detailed medical record abstraction complements the assessment with diagnostic study results, in-hospital procedures, and medications. Participants are subsequently followed for six months to determine hospital readmission, mortality, and health status decline. Multivariable regression will be used to develop risk models for these three outcomes. SILVER-AMI will fill critical gaps in our understanding of AMI in older patients. By incorporating geriatric impairments into our understanding of post-AMI outcomes, we aim to create a more personalized assessment of risk and identify potential targets for interventions. NCT01755052 .

  1. Evolution of the ATLAS Metadata Interface (AMI)

    CERN Document Server

    Odier, Jerome; The ATLAS collaboration; Fulachier, Jerome; Lambert, Fabian

    2015-01-01

    The ATLAS Metadata Interface (AMI) can be considered to be a mature application because it has existed for at least 10 years. Over the years, the number of users and the number of functions provided for these users has increased. It has been necessary to adapt the hardware infrastructure in a seamless way so that the Quality of Service remains high. We will describe the evolution of the application from the initial one, using single server with a MySQL backend database, to the current state, where we use a cluster of Virtual Machines on the French Tier 1 Cloud at Lyon, an ORACLE database backend also at Lyon, with replication to CERN using ORACLE streams behind a back-up server.

  2. 76 FR 13127 - Action Affecting Export Privileges; Amy Farrow

    Science.gov (United States)

    2011-03-10

    ... Bureau of Industry and Security Action Affecting Export Privileges; Amy Farrow In the Matter of: Amy... Export Administration Regulations (the ``Regulations'') \\1\\ and Section 13(c) of the Export... Emergency Economic Powers Act (50 U.S.C. 1701 et seq.). Charges 1-116 15 CFR 764.2(a): Exporting Stun...

  3. AmiE, a novel N-acylhomoserine lactone acylase belonging to the amidase family, from the activated-sludge isolate Acinetobacter sp. strain Ooi24.

    Science.gov (United States)

    Ochiai, Seiji; Yasumoto, Sera; Morohoshi, Tomohiro; Ikeda, Tsukasa

    2014-11-01

    Many Gram-negative bacteria use N-acyl-l-homoserine lactones (AHLs) as quorum-sensing signal molecules. We have reported that Acinetobacter strains isolated from activated sludge have AHL-degrading activity. In this study, we cloned the amiE gene as an AHL-degradative gene from the genomic library of Acinetobacter sp. strain Ooi24. High-performance liquid chromatography analysis revealed that AmiE functions as an AHL acylase, which hydrolyzes the amide bond of AHL. AmiE showed a high level of degrading activity against AHLs with long acyl chains but no activity against AHLs with acyl chains shorter than eight carbons. AmiE showed homology with a member of the amidases (EC 3.5.1.4) but not with any known AHL acylase enzymes. An amino acid sequence of AmiE from Ooi24 showed greater than 99% identities with uncharacterized proteins from Acinetobacter ursingii CIP 107286 and Acinetobacter sp. strain CIP 102129, but it was not found in the draft or complete genome sequences of other Acinetobacter strains. The presence of transposase-like genes around the amiE genes of these three Acinetobacter strains suggests that amiE is transferred by a putative transposon. Furthermore, the expression of AmiE in Pseudomonas aeruginosa PAO1 reduced AHL accumulation and elastase activity, which were regulated by AHL-mediated quorum sensing.

  4. Bowen fluorescence from companion stars in x-ray Binaries

    Directory of Open Access Journals (Sweden)

    J. Casares

    2004-01-01

    Full Text Available Este art culo examina una nueva t ecnica para detectar estrellas compa~neras en los LMXB y las transitorias de rayos X durante la transferencia de masa utilizando las l neas NIII uorescentes de Bowen en 4634-4640. Estas l neas se reprocesan muy e cientemente en las atm osferas de las estrellas compa~neras proporcionando estimaciones de las velocidades K2 y funciones de masas. Este m etodo se aplic o a Sco X-1, X 822-371 y GB339-4 el cual, en este ultimo caso, proporciona una evidencia din amica de la presencia de un agujero negro acreciente. Tambi en se presentan resultados preliminares de una campa~na VLT sobre V801 Ara, V926 Sco y XTE J1814-338.

  5. [Oncogenic human papillomaviruses in extra-genital Bowen disease revealed by in situ hybridization].

    Science.gov (United States)

    Derancourt, C; Mougin, C; Chopard Lallier, M; Coumes-Marquet, S; Drobacheff, C; Laurent, R

    2001-01-01

    The association between mucosal oncogenic human papillomaviruses (HPV) and bowenoid papulosis or genital Bowen's disease is well documented. In contrast this association with extra-genital Bowen's disease is poorly studied. The aim of this study was to detect oncogenic (16/18, 31/33/51) and non oncogenic (8/11) mucosal HPV using a in situ hybridization method in 28 skin biopsy specimens of extra-genital Bowen's disease. Twenty-eight cases of extra-genital Bowen's disease seen in the period 1990-96 in the Dermatology department were included: 19 women and 9 men (mean age: 72 years). Bowen's disease locations were: hands and feet (8 cases), limbs (11 cases), face (8 cases), trunk (1 case). Blinded histopathologic examination confirmed the diagnosis of Bowen's disease and signs of HPV infection (koilocytosis). In situ hybridization was performed using three biotinylated probes detecting HPV types 6/11, 16/18, 31/33/51. Oncogenic HPV genoma was detected in 8 skin samples (28.6 p. 100). In all these cases, 16/18 probe was positive and in two cases, both 16/18 and 31/33/51 probes were positive; 4/8 Bowen's diseases of the extremities were positive for HPV. Koilocytes were found in 6/8 of skin samples with positive HPV detection. Mucosal oncogenic HPV are detected by in situ hybridization in 28.6 p. 100 of extra-genital Bowen's disease. In situ hybridization is an easier technique than Southern-Blot hybridization which is the gold standard. Five studies reported similar results and three studies reported different results that we discuss. A precise understanding of oncogenic HPV implication in the development of extra-genital Bowen's disease could lead to the development of new therapeutic strategies (topical cidofovir or imiquimod).

  6. Evolving the Bowen-York initial data for spinning black holes

    CERN Document Server

    Gleiser, R J; Price, R; Pullin, J; Gleiser, Reinaldo; Nicasio, Oscar; Price, Richard; Pullin, Jorge

    1998-01-01

    The Bowen-York initial value data typically used in numerical relativity to represent spinning black hole are not those of a constant-time slice of the Kerr spacetime. If Bowen-York initial data are used for each black hole in a collision, the emitted radiation will be partially due to the ``relaxation'' of the individual holes to Kerr form. We compute this radiation by treating the geometry for a single hole as a perturbation of a Schwarzschild black hole, and by using second order perturbation theory. We discuss the extent to which Bowen-York data can be expected accurately to represent Kerr holes.

  7. Tests of AMiBA Data Integrity

    CERN Document Server

    Nishioka, Hiroaki; Wu, Jiun-Huei Proty; Ho, Paul T P; Huang, Chih-Wei Locutus; Koch, Patrick M; Liao, Yu-Wei; Lin, Kai-Yang; Liu, Guo-Chin; Molnar, Sandor M; Umetsu, Keiichi; Birkinshaw, Mark; Altamirano, Pablo; Chang, Chia-Hao; Chang, Shu-Hao; Chang, Su-Wei; Chen, Ming-Tang; Han, Chih-Chiang; Huang, Yau-De; Hwang, Yuh-Jing; Jiang, Homin; Kesteven, Michael; Kubo, Derek Y; Li, Chao-Te; Martin-Cocher, Pierre; Oshiro, Peter; Raffin, Philippe; Wei, Tashun; Wilson, Warwick

    2008-01-01

    We describe methods used to validate data from the Y.T. Lee Array for Microwave Background Anisotropy (AMiBA), an interferometric array designed to measure the Sunyaev-Zel'dovich effect and the anisotropy of the Cosmic Microwave Background (CMB). We perform several statistical tests on data from pointed galaxy cluster observations taken in 2007 and noise data from long-term blank sky observations and measurements with the feeds covered by the absorbers. We apply power spectrum analysis, cross power spectrum analysis among different outputs with different time lags in our analog correlator, and sample variance law tests to noise data. We find that (1) there is no time variation of electronic offsets on the time scale of our two-patch observations (~10 minutes); (2) noise is correlated by less than 10% between different lags; and (3) the variance of noise scales with the inverse of time. To test the Gaussianity of the data, we apply Kolmogorov-Smirnov (K-S) tests to cluster data, and find that a 5% significance...

  8. ATLAS Metadata Interface (AMI), a generic metadata framework

    CERN Document Server

    Fulachier, Jerome; The ATLAS collaboration

    2017-01-01

    The ATLAS Metadata Interface (AMI) is a mature application of more than 15 years of existence. Mainly used by the ATLAS experiment at CERN, it consists of a very generic tool ecosystem for metadata aggregation and cataloguing. We briefly describe the architecture, the main services and the benefits of using AMI in big collaborations, especially for high energy physics. We focus on the recent improvements, for instance: the lightweight clients (Python, JavaScript, C++), the new smart task server system and the Web 2.0 AMI framework for simplifying the development of metadata-oriented web interfaces.

  9. A utility of AMI-25 enhanced MRI for HCC

    Energy Technology Data Exchange (ETDEWEB)

    Matsuda, Hiromichi; Saito, Kazuhiro; Saguchi, Tohru (Tokyo Medical Coll. (Japan)) (and others)

    1993-05-01

    After injection of superparamagnetic iron oxide (AMI-25), the detection number of hepatocellular carcinoma (HCC) increased over 2 times. But in some cases, contrast to noise ratio did not change. The most excellent pulse sequence for detection of HCC was T2-weighted images, but field echo image had a better capability due to a strong T2 relaxation. Two cases of adenomatous hyperplasia decreased their signal intensities after injection of AMI-25, but well differentiated HCC also did. In two HCCs with peripheral hyperintensity (PHI), one of PHI disappeared on the AMI-25 enhanced MRI, but another did not. (author).

  10. ATLAS Metadata Interface (AMI), a generic metadata framework

    CERN Document Server

    Fulachier, Jerome; The ATLAS collaboration

    2016-01-01

    The ATLAS Metadata Interface (AMI) is a mature application of more than 15 years of existence. Mainly used by the ATLAS experiment at CERN, it consists of a very generic tool ecosystem for metadata aggregation and cataloguing. We briefly describe the architecture, the main services and the benefits of using AMI in big collaborations, especially for high energy physics. We focus on the recent improvements, for instance: the lightweight clients (Python, Javascript, C++), the new smart task server system and the Web 2.0 AMI framework for simplifying the development of metadata-oriented web interfaces.

  11. Broadband PLC for Clustered Advanced Metering Infrastructure (AMI Architecture

    Directory of Open Access Journals (Sweden)

    Augustine Ikpehai

    2016-07-01

    Full Text Available Advanced metering infrastructure (AMI subsystems monitor and control energy distribution through exchange of information between smart meters and utility networks. A key challenge is how to select a cost-effective communication system without compromising the performance of the applications. Current communication technologies were developed for conventional data networks with different requirements. It is therefore necessary to investigate how much of existing communication technologies can be retrofitted into the new energy infrastructure to cost-effectively deliver acceptable level of service. This paper investigates broadband power line communications (BPLC as a backhaul solution in AMI. By applying the disparate traffic characteristics of selected AMI applications, the network performance is evaluated. This study also examines the communication network response to changes in application configurations in terms of packet sizes. In each case, the network is stress-tested and performance is assessed against acceptable thresholds documented in the literature. Results show that, like every other communication technology, BPLC has certain limitations; however, with some modifications in the network topology, it indeed can fulfill most AMI traffic requirements for flexible and time-bounded applications. These opportunities, if tapped, can significantly improve fiscal and operational efficiencies in AMI services. Simulation results also reveal that BPLC as a backhaul can support flat and clustered AMI structures with cluster size ranging from 1 to 150 smart meters.

  12. Obesity, starch digestion and amylase: association between copy number variants at human salivary (AMY1) and pancreatic (AMY2) amylase genes.

    Science.gov (United States)

    Carpenter, Danielle; Dhar, Sugandha; Mitchell, Laura M; Fu, Beiyuan; Tyson, Jess; Shwan, Nzar A A; Yang, Fengtang; Thomas, Mark G; Armour, John A L

    2015-06-15

    The human salivary amylase genes display extensive copy number variation (CNV), and recent work has implicated this variation in adaptation to starch-rich diets, and in association with body mass index. In this work, we use paralogue ratio tests, microsatellite analysis, read depth and fibre-FISH to demonstrate that human amylase CNV is not a smooth continuum, but is instead partitioned into distinct haplotype classes. There is a fundamental structural distinction between haplotypes containing odd or even numbers of AMY1 gene units, in turn coupled to CNV in pancreatic amylase genes AMY2A and AMY2B. Most haplotypes have one copy each of AMY2A and AMY2B and contain an odd number of copies of AMY1; consequently, most individuals have an even total number of AMY1. In contrast, haplotypes carrying an even number of AMY1 genes have rearrangements leading to CNVs of AMY2A/AMY2B. Read-depth and experimental data show that different populations harbour different proportions of these basic haplotype classes. In Europeans, the copy numbers of AMY1 and AMY2A are correlated, so that phenotypic associations caused by variation in pancreatic amylase copy number could be detected indirectly as weak association with AMY1 copy number. We show that the quantitative polymerase chain reaction (qPCR) assay previously applied to the high-throughput measurement of AMY1 copy number is less accurate than the measures we use and that qPCR data in other studies have been further compromised by systematic miscalibration. Our results uncover new patterns in human amylase variation and imply a potential role for AMY2 CNV in functional associations.

  13. A new method to measure bowen ratios using high resolution vertical dry and wet bulb temperature profiles

    NARCIS (Netherlands)

    Euser, T.; Luxemburg, W.; Everson, C.; Mengistu, M.; Clulow, A.; Bastiaanssen, W.

    2013-01-01

    The Bowen ratio surface energy balance method is a relatively simple method to determine the latent heat flux and the actual land surface evaporation. Despite its simplicity, the Bowen ratio method is generally considered to be unreliable due to the use of two-level sensors that are installed by def

  14. Evolving the Bowen-York initial data for spinning black holes

    OpenAIRE

    1997-01-01

    The Bowen-York initial value data typically used in numerical relativity to represent spinning black hole are not those of a constant-time slice of the Kerr spacetime. If Bowen-York initial data are used for each black hole in a collision, the emitted radiation will be partially due to the ``relaxation'' of the individual holes to Kerr form. We compute this radiation by treating the geometry for a single hole as a perturbation of a Schwarzschild black hole, and by using second order perturbat...

  15. The AMI Meeting Corpus: A Pre-announcement

    NARCIS (Netherlands)

    Carletta, Jean; Ashby, Simone; Bourban, Sebastien; Flynn, Mike; Guillemot, Mael; Hain, Thomas; Kadlec, Jaroslav; Karaiskos, Vasilis; Kraaij, Wessel; Kronenthal, Melissa; Lathoud, Guillaume; Lincoln, Mike; Lisowska, Agnes; McCowan, Iain; Post, Wilfried; Reidsma, Dennis; Wellner, Pierre; Renals, S.; Bengio, S.

    2006-01-01

    The AMI Meeting Corpus is a multi-modal data set consisting of 100 hours of meeting recordings. It is being created in the context of a project that is developing meeting browsing technology and will eventually be released publicly. Some of the meetings it contains are naturally occurring, and some

  16. Missed Opportunities To Impact Fast Response to AMI Symptoms.

    Science.gov (United States)

    Zapka, Jane G.; Oakes, J. Michael; Simons-Morton, Denise G.; Mann, N. Clay; Goldberg, Robert; Sellers, Deborah E.; Estabrook, Barbara; Gilliland, Janice; Linares, Adriana C.; Benjamin-Garner, Ruby; McGovern, Paul

    2000-01-01

    Examines factors that influence the prompt seeking of care for symptoms of acute myocardial infarction (AMI). Survey of adults in 20 communities in 10 states confirmed the importance of attrition and perceived self-confidence in symptom recognition in care seeking. Concludes that the lack of a significant role of health history and clinician…

  17. A case of Bowen’s disease responding well to radiotherapy

    Directory of Open Access Journals (Sweden)

    Goknur Kalkan

    2013-08-01

    Full Text Available Bowen’s disease is a form of intraepidermal squamous cell carcinoma which is known as carsinoma in situ. The head, neck, and extremities are the most commonly affected anatomic locations. Treatment options for Bowen’s disease include observation, surgery, cryotherapy, electrodesiccation and curettage, topical application of 5-fluorouracil or imiquimod, Moh’s micrographic surgery, photodynamic therapy, and radiotherapy. Radiation therapy is advantageous in patients who refuse surgery, for large or multiple lesions, for lesions in cosmetically sensitive areas, and in patients who are predisposed to formation of keloids, with a high cure rate cited in the literature. Here we report a 70-year-old man who was diagnosed as Bowen’s disease and completely healed with the treatment of radiotherapy. By means of this case report, we will review the current literature and empasize that radiotherapy is an effective treatment alternative for Bowen's disease in the suitable lesions. [Cukurova Med J 2013; 38(4.000: 813-817

  18. Play, Healing, and Wellness as Seen by a Physician Who Clowns: An Interview with Bowen White

    Science.gov (United States)

    American Journal of Play, 2009

    2009-01-01

    Bowen White is a physician. He founded the Department of Preventive and Stress Medicine at the Baptist Medical Center in Kansas City, Missouri, in 1983 and later established the center's Department of Wellness and Health Promotion. White is also a clown who goes by the name of Dr. Jerko. For years he mixed these dual interests, skills, and egos…

  19. 41 CFR 102-33.455 - What is C-AMIS?

    Science.gov (United States)

    2010-07-01

    ... Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 33-MANAGEMENT OF GOVERNMENT AIRCRAFT Reporting Information on Government Aircraft Common Aviation Management Information Standard (c-Amis) § 102-33.455 What is C-AMIS? Common Aviation Management Information Standard (C-AMIS),...

  20. Multiscale Variability of the Tropopause Transition Layer During AMIE

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Richard H. [Colorado State Univ., Fort Collins, CO (United States). Dept. of Atmospheric Science; Birner, Thomas [Colorado State Univ., Fort Collins, CO (United States). Dept. of Atmospheric Science

    2016-11-28

    An investigation has been carried out of the influence of the Madden-Julian Oscillation on the tropical tropopause layer (TTL) using data from the ARM MJO Investigation Experiment (AMIE) during the period October-November 2011. A variety of data from the ARM Mobile Facility deployed during AMIE on Gan Island have been used in the study: 3-hourly atmospheric soundings, the Ka-band ARM Zenith Radar (KAZR) radar reflectivity fields, and the ARM PI-Product CombRet (Combined Retrieval, Microphysical Retrievals, and Heating Rates) produced by PNNL. Additional data used in the study are from CALIPSO, ERAi reanalyses, DYNAMO (Dynamics of the MJO) sounding network observations, the S-PolKa radar on Gan Island, and the DOE ARM sites at Manus and Nauru.

  1. Interannual variation of the Bowen ratio in a subtropical coniferous plantation in southeast China, 2003-2012.

    Science.gov (United States)

    Tang, Yakun; Wen, Xuefa; Sun, Xiaomin; Wang, Huimin

    2014-01-01

    The interannual variation of the Bowen ratio, through its effect on the warming extent of available energy to the ecosystem land surface air, heavily influences the ecosystem microclimate and affects the hydrological cycle at both regional and global scales. Although the precipitation amount in southeast China is not expected to change greatly as a result of climate change, the precipitation frequency may be altered in the future. We explored the interannual variation of the Bowen ratio and its affecting mechanisms based on eddy covariance measurements in a subtropical plantation in southeast China during 2003-2012. The results indicated that the annual mean Bowen ratio was 0.35 ± 0.06, with a range of 0.29-0.45. The Bowen ratio during the dry season (July-October) positively correlated with the annual Bowen ratio (R(2) = 0.85, p<0.001). The effective precipitation frequency during the dry season, through its positive effect on shallow soil water content, indirectly and negatively affected the annual Bowen ratio. Between 2003 and 2012, the annual Bowen ratio exhibited a marginally significant decreasing trend (p = 0.061), meanwhile the effective precipitation frequency and shallow soil water content during the dry season increased significantly (p<0.001). The annual Bowen ratio may decrease further if the effective precipitation frequency and shallow soil water content during the dry season follow similar trends in the future. The warming effect of available energy to the surface air of our studied plantation may decline with the decreasing annual Bowen ratio.

  2. The AMY experiment: Microwave emission from air shower plasmas

    Directory of Open Access Journals (Sweden)

    Alvarez-Muñiz J.

    2016-01-01

    Full Text Available You The Air Microwave Yield (AMY experiment investigate the molecular bremsstrahlung radiation emitted in the GHz frequency range from an electron beam induced air-shower. The measurements have been performed at the Beam Test Facility (BTF of Frascati INFN National Laboratories with a 510 MeV electron beam in a wide frequency range between 1 and 20 GHz. We present the apparatus and the results of the tests performed.

  3. Determination of CKMB Activity and Protein Concentration and Their Application in the Diagnosis of AMI

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The activity and protein concentration of CKMB in 19 patients with AMI, 17 non-AMI patients and 26 normal persons. It was found that both peak times in patients with AMI and nonAMI patients were similar but the peak values were different. At peak values, the F value of CKMB (5. 3) was much lower than that of CKMB protein concentration (50. 1). We are led to conclude that the measurement of CKMB protein level can identify AMI much earlier than that of CKMB activity.

  4. AmI and Deployment Considerations in AAL Services Provision for Elderly Independent Living: The MonAMI Project

    Directory of Open Access Journals (Sweden)

    Alejandro Ibarz

    2013-07-01

    Full Text Available The MonAMI project aims to investigate the feasibility of the deployment of open platforms for Ambient Assisted Living (AAL services provision based on Ambient Intelligence (AmI and to test user acceptance and the usability of the services. Services were designed to provide support in the areas of environmental control, security, well-being and leisure. These services were installed and evaluated in a Spanish geriatric residence. The participants included elderly persons with disabilities, nursing home care givers and informal carers. The concept of the open platform proved to be satisfactory for the provision of the services in a context aware framework. Furthermore, the usability of the technology was viewed positively and the overall results indicate that this system has the potential to prolong independent living at home for elderly people with disabilities. Deployment was proven successful and awareness of open-platform AAL service delivery was raised in local communities throughout Europe.

  5. Are AMI patients with comorbid mental illness more likely to be admitted to hospitals with lower quality of AMI care?

    Directory of Open Access Journals (Sweden)

    Xueya Cai

    Full Text Available OBJECTIVE: Older patients with comorbid mental illness are shown to receive less appropriate care for their medical conditions. This study analyzed Medicare patients hospitalized for acute myocardial infarction (AMI and determined whether those with comorbid mental illness were more likely to present to hospitals with lower quality of AMI care. METHODS: Retrospective analyses of Medicare claims in 2008. Hospital quality was measured using the five "Hospital Compare" process indicators (aspirin at admission/discharge, beta-blocker at admission/discharge, and angiotension-converting enzyme inhibitor or angiotension receptor blocker for left ventricular dysfunction. Multinomial logit model determined the association of mental illness with admission to low-quality hospitals (rank of the composite process score 90(th percentile, compared to admissions to other hospitals with medium quality. Multivariate analyses further determined the effects of hospital type and mental diagnosis on outcomes. RESULTS: Among all AMI admissions to 2,845 hospitals, 41,044 out of 287,881 patients were diagnosed with mental illness. Mental illness predicted a higher likelihood of admission to low-quality hospitals (unadjusted rate 2.9% vs. 2.0%; adjusted odds ratio [OR]1.25, 95% confidence interval [CI] 1.17-1.34, p<0.01, and an equal likelihood to high-quality hospitals (unadjusted rate 9.8% vs. 10.3%; adjusted OR 0.97, 95% CI 0.93-1.01, p = 0.11. Both lower hospital quality and mental diagnosis predicted higher rates of 30-day readmission, 30-day mortality, and 1-year mortality. CONCLUSIONS: Among Medicare myocardial infarction patients, comorbid mental illness was associated with an increased risk for admission to lower-quality hospitals. Both lower hospital quality and mental illness predicted worse post-AMI outcomes.

  6. AmyR is a novel negative regulator of amylovoran production in Erwinia amylovora.

    Directory of Open Access Journals (Sweden)

    Dongping Wang

    Full Text Available In this study, we attempted to understand the role of an orphan gene amyR in Erwinia amylovora, a functionally conserved ortholog of ybjN in Escherichia coli, which has recently been characterized. Amylovoran, a high molecular weight acidic heteropolymer exopolysaccharide, is a virulent factor of E. amylovora. As reported earlier, amylovoran production in an amyR knockout mutant was about eight-fold higher than that in the wild type (WT strain of E. amylovora. When a multicopy plasmid containing the amyR gene was introduced into the amyR mutant or WT strains, amylovoran production was strongly inhibited. Furthermore, amylovoran production was also suppressed in various amylovoran-over-producing mutants, such as grrSA containing multicopies of the amyR gene. Consistent with amylovoran production, an inverse correlation was observed between in vitro expression of amyR and that of amylovoran biosynthetic genes. However, both the amyR knockout mutant and over-expression strains showed reduced levan production, another exopolysaccharide produced by E. amylovora. Virulence assays demonstrated that while the amyR mutant was capable of inducing slightly greater disease severity than that of the WT strain, strains over-expressing the amyR gene did not incite disease on apple shoots or leaves, and only caused reduced disease on immature pear fruits. Microarray studies revealed that amylovoran biosynthesis and related membrane protein-encoding genes were highly expressed in the amyR mutant, but down-regulated in the amyR over-expression strains in vitro. Down-regulation of amylovoran biosynthesis genes in the amyR over-expression strain partially explained why over-expression of amyR led to non-pathogenic or reduced virulence in vivo. These results suggest that AmyR plays an important role in regulating exopolysaccharide production, and thus virulence in E. amylovora.

  7. AmyR is a novel negative regulator of amylovoran production in Erwinia amylovora.

    Science.gov (United States)

    Wang, Dongping; Korban, Schuyler S; Pusey, P Lawrence; Zhao, Youfu

    2012-01-01

    In this study, we attempted to understand the role of an orphan gene amyR in Erwinia amylovora, a functionally conserved ortholog of ybjN in Escherichia coli, which has recently been characterized. Amylovoran, a high molecular weight acidic heteropolymer exopolysaccharide, is a virulent factor of E. amylovora. As reported earlier, amylovoran production in an amyR knockout mutant was about eight-fold higher than that in the wild type (WT) strain of E. amylovora. When a multicopy plasmid containing the amyR gene was introduced into the amyR mutant or WT strains, amylovoran production was strongly inhibited. Furthermore, amylovoran production was also suppressed in various amylovoran-over-producing mutants, such as grrSA containing multicopies of the amyR gene. Consistent with amylovoran production, an inverse correlation was observed between in vitro expression of amyR and that of amylovoran biosynthetic genes. However, both the amyR knockout mutant and over-expression strains showed reduced levan production, another exopolysaccharide produced by E. amylovora. Virulence assays demonstrated that while the amyR mutant was capable of inducing slightly greater disease severity than that of the WT strain, strains over-expressing the amyR gene did not incite disease on apple shoots or leaves, and only caused reduced disease on immature pear fruits. Microarray studies revealed that amylovoran biosynthesis and related membrane protein-encoding genes were highly expressed in the amyR mutant, but down-regulated in the amyR over-expression strains in vitro. Down-regulation of amylovoran biosynthesis genes in the amyR over-expression strain partially explained why over-expression of amyR led to non-pathogenic or reduced virulence in vivo. These results suggest that AmyR plays an important role in regulating exopolysaccharide production, and thus virulence in E. amylovora.

  8. The predictive values of D-dimer for the early prognosis of the acute myocardial infarction(AMI):a review of 3134 AMI patients

    Institute of Scientific and Technical Information of China (English)

    杨军

    2013-01-01

    Objective To investigate whether D-dimer could be an early warning signal for patients with acute myocardial infarction(AMI),then may be helpful in risk accessment in emergency department. Methods Three thousand one hundred and thirty-four emergency AMI cases admitted to

  9. Former Intern: Amy Stull Returns to Her Roots | Poster

    Science.gov (United States)

    By Carolynne Keenan, Contributing Writer When Amy Stull, a 2000 graduate of Walkersville High School, began working in a laboratory at the National Cancer Institute (NCI) at Frederick, she likely did not know the role NCI would play in her career. Stull started at NCI as a Werner H. Kirsten (WHK) student intern after her junior year of high school, working in a lab as she prepared for a career in chemical engineering. The student intern program pairs rising high school seniors with laboratory scientists to encourage the students to pursue careers in both science and health care fields.

  10. Evolution of the Architecture of the ATLAS Metadata Interface (AMI)

    CERN Document Server

    Odier, Jerome; The ATLAS collaboration; Fulachier, Jerome; Lambert, Fabian

    2015-01-01

    The ATLAS Metadata Interface (AMI) is now a mature application. Over the years, the number of users and the number of provided functions has dramatically increased. It is necessary to adapt the hardware infrastructure in a seamless way so that the quality of service remains high. We describe the evolution from the beginning of the application life, using one server with a MySQL backend database, to the current state in which a cluster of virtual machines on the French Tier 1 cloud at Lyon, an Oracle database also at Lyon, with replication to Oracle at CERN and a back-up server are used.

  11. Analysis on the Theme of Amy Lowell’s Patterns

    Institute of Scientific and Technical Information of China (English)

    祝小玉

    2014-01-01

    There are a lot of, or precisely speaking, a train of patterns in Amy Lowell’s Patterns for it seems to be consisted of dis-parate patterns but as a matter of fact these seemingly disrelated patterns disclose one pattern together from the points of both fem-inism and psychology. And this paper is aimed to discover the inherent co-relationship among these different patterns and shed light on the theme of this pome, in other words, the feminism of this pome.

  12. Genital Bowenʼs Disease in a Bulgarian Patient: Complete Remission after Surgical Approach

    Directory of Open Access Journals (Sweden)

    Georgi Tchernev

    2017-07-01

    Full Text Available A 60-year-old male patient presented with complaints of persistent red to a brown-colored plaque on his scrotum, with duration of approximately three years. The patient had been treated with oral and topical antifungals for inguinal tinea for several months and after that with topical corticosteroids for eczema for several more months. None of the regimens achieved any therapeutic effect. The histopathological evaluation revealed the presence of atypical keratinocytes in all layers of the epidermis with the altered epidermal pattern, spread parabasal mitotic activity, without secondary satellites, multiple dyskeratotic cells and multinucleated cells. The diagnosis of an intraepithelial non-invasive squamous cell carcinoma, associated with koilocytic dysplasia and hyperplasia was made, meeting the criteria for Bowen disease. An elliptic surgical excision of the lesion was made, while the defect was closed with single stitches, with excellent therapeutic and aesthetic result. First described by John T. Bowen in 1912, Bowen disease (BD represents a squamous cell carcinoma (SCC in situ with the potential for significant lateral spread. Treatment options include the application of topical 5-flurorouracil cream – useful in non-hairy areas, imiquimod cream or destructive methods such as radiation, curettage, cryotherapy, laser ablation and photodynamic therapy, especially useful in nail bed involvement. Despite the early lesions, surgical excision is the preferred treatment option, regarding the potential malignant transformation risk.

  13. A Key Management Scheme for ZigBee in AMI of Smart Grid

    Institute of Scientific and Technical Information of China (English)

    Jianquan Liang; Xianji Jin; Shuidong Dai; Weiming Tong; Zhongwei Li

    2016-01-01

    Advanced metering infrastructure ( AMI) is a critical part of the smart grid, and ZigBee is playing an increasingly important role in AMI. The cyber security is the prerequisite to ensure the reliable operation of AMI. To guarantee the ZigBee communication security in AMI, a key management scheme based on the elliptic curve cryptosystem ( ECC) is proposed. According to the ways of information transformation in AMI, the scheme is categorized as unicast communication key management process and multicast communication key management process. And in the scheme, the selection of elliptic curve, the calculation of ZigBee node’ s ECC public key and private key, the establishment and distribution of the link key in unicast communication, and the establishment and distribution of the network key in multicast communication are elaborated. The analysis results show that the proposed key management scheme is secure, and consumes less memory and energy, thus, can meet the demands of communication security of AMI.

  14. A new method to measure bowen ratios using high resolution vertical dry and wet bulb temperature profiles

    Directory of Open Access Journals (Sweden)

    T. Euser

    2013-06-01

    Full Text Available The Bowen ratio surface energy balance method is a relatively simple method to determine the latent heat flux and the actual land surface evaporation. Despite its simplicity, the Bowen ratio method is generally considered to be unreliable due to the use of two-level sensors that are installed by default in operational Bowen ratio systems. In this paper we present the concept of a new measurement methodology to estimate the Bowen ratio from high resolution vertical dry and wet bulb temperature profiles. A short field experiment with Distributed Temperature Sensing (DTS in a fibre optic cable having 13 levels was undertaken. A dry and a wetted section of a fibre optic cable were suspended on a 6 m high tower installed over a sugar beet trial near Pietermaritzburg (South Africa. Using the DTS cable as a psychrometer, a near continuous observation of vapour pressure and temperature at 0.20 m intervals was established. These data allows the computation of the Bowen ratio with a high precision. By linking the Bowen ratio to net radiation and soil heat flux, the daytime latent heat flux was estimated. The latent heat flux derived from DTS-based Bowen ratio (BR-DTS showed consistent agreement (correlation coefficients between 0.97 and 0.98 with results derived from eddy covariance, surface layer scintillometer and surface renewal techniques. The latent heat from BR-DTS overestimated the latent heat derived with the eddy covariance by 4% and the latent heat derived with the surface layer scintillometer by 8%. Through this research, a new window is opened to engage on simplified, inexpensive and easy to interpret in situ measurement techniques for measuring evaporation.

  15. Doença de bowen perianal - diagnóstico e tratamento: relato de caso Perianal bowen's disease - diagnosis and treatment: case report

    Directory of Open Access Journals (Sweden)

    Luciana Paes Peixoto Netto

    2009-03-01

    Full Text Available Os autores relatam um caso e objetivam a discussão sobre a Doença de Bowen. Patologia de ocorrência rara, principalmente na região perianal. Trata-se de um carcinoma escamoso in situ com potencial invasor. Apresenta como característica marcante alterações histopatológicas da epiderme que não ultrapassam a membrana basal. É doença de evolução lenta, oligo ou assintomática e de aspecto macroscópico variável. Assim sendo, muitas vezes o diagnóstico é retardado. A confirmação diagnóstica se dá por biópsia e estudo histopatológico. O tratamento de escolha, por seus menores índices de recidiva, é a ressecção cirúrgica com margens amplas. A utilização de enxertos ou retalhos é frequentemente necessária para corrigir o defeito cutâneo deixado e permitir a cicatrização satisfatória.The authors report a case and aimed at discussing about Bowen's disease, an unusual pathology, especially in perianal area. It is an in situ carcinoma with invasive potential. Epidermal's histological abnormalities with basal membrane preservation is its main characteristic. This disease presents a slow progression, few or no specific symptoms and variable macroscopic aspect. These facts lead in several times to a late diagnosis. Biopsies and histopathological study confirm the diagnosis. The treatment of choice is wide surgical resection. Often it is necessary to utilize grafts or flaps to correct the cutaneous defects and allows a satisfactory cicatrization.

  16. System mass constraints for the accreting millisecond pulsar XTE J1814-338 using Bowen fluorescence

    Science.gov (United States)

    Wang, L.; Steeghs, D.; Casares, J.; Charles, P. A.; Muñoz-Darias, T.; Marsh, T. R.; Hynes, R. I.; O'Brien, K.

    2017-04-01

    We present phase-resolved spectroscopy of the millisecond X-ray pulsar XTE J1814-338 obtained during its 2003 outburst. The spectra are dominated by high-excitation emission lines of He II λ4686, Hβ, and the Bowen blend C III/N III 4630-50 Å. We exploit the proven Bowen fluorescence technique to establish a complete set of dynamical system parameter constraints using bootstrap Doppler tomography, a first for an accreting millisecond X-ray pulsar binary. The reconstructed Doppler map of the N III λ4640 Bowen transition exhibits a statistically significant (>4σ) spot feature at the expected position of the companion star. If this feature is driven by irradiation of the surface of the Roche lobe filling companion, we derive a strict lower limit to the true radial velocity semi-amplitude K2. Combining our donor constraint with the well-constrained orbit of the neutron star leads to a determination of the binary mass ratio: q = 0.123^{+0.012}_{-0.010}. The component masses are not tightly constrained given our lack of knowledge of the binary inclination. We cannot rule out a canonical neutron star mass of 1.4 M⊙ (1.1 M⊙ confidence limits of M2 are consistent with the companion being a significantly bloated, M-type main-sequence star. Our findings, combined with results from studies of the quiescent optical counterpart of XTE J1814-338, suggest the presence of a rotation-powered millisecond pulsar in XTE J1814-338 during an X-ray quiescent state. The companion mass is typical of the so-called redback pulsar binary systems (M2 ˜ 0.2 M⊙).

  17. Clinical, histological, and immunohistochemical markers of resistance to Methyl-aminolevulinate Photodynamic therapy in Bowen's disease.

    Science.gov (United States)

    Gracia-Cazaña, T; Salazar, N; Vera-Álvarez, J; Aguilera, J; López-Navarro, N; Herrera-Ceballos, E; González, S; Juarranz, Á; Gilaberte, Y

    2017-09-08

    Bowen's disease (BD) is an intraepidermic squamous cell carcinoma (SCC), which principally appears on photoexposed areas.(1) Methyl-aminolevulinate (MAL) photodynamic therapy (PDT) is an excellent option for the treatment of BD (strength of recommendation, A; quality of evidence, 1). However, despite good response rates, some tumors prove non-responsive due to primary or acquired resistance.(2) The present study sought to identify clinical, histological, and molecular variables implicated in the response to MAL-PDT in BD. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  18. Co-existence of porokeratosis variants concurrent with Bowen's disease: two rare cases report.

    Science.gov (United States)

    Korviriyakamol, Tarinee; Kattipathananpong, Pinnaree; Chunhasewee, Chakkrapong; Wessagowit, Vesarat; Kootiratrakarn, Tanawatt

    2014-03-01

    Coexisting variants of porokeratosis rarely occurs. Disseminated superficial porokeratosis (DSP) is characterized by multiple uniform small annular papules distributed all over body. DSP commonly coexist with linear porokeratosis (LP), but it is uncommon for DSP to coexist with porokeratosis of Mibelli (PM). PM presents with central atrophic erythematous plaques and thread-like elevated border. It occurs mainly on extremities. Although malignant transformation can be found in the porokeratosis, there is still no report case of coexisting variants of porokeratosis concurrent with Bowen's disease. The clinical and histopathologic finding of rare coexisting variants of porokeratosis (PM and DSP) concurrent with squamous dysplasia is described.

  19. 41 CFR 102-33.460 - What is our responsibility in relation to C-AMIS?

    Science.gov (United States)

    2010-07-01

    ... 33-MANAGEMENT OF GOVERNMENT AIRCRAFT Reporting Information on Government Aircraft Common Aviation Management Information Standard (c-Amis) § 102-33.460 What is our responsibility in relation to C-AMIS? If you use a management information system to provide data to FAIRS by batch upload, you are...

  20. Quest for Self—An Interpretation of Amy Tan's The Joy Luck Club

    Institute of Scientific and Technical Information of China (English)

    杨平

    2015-01-01

    Based on the text analysis of Amy Tan's The Joy Luck Club this dissertation tries to prove that Amy Tan uses this semi-autobiographical novel as attempted quests for her identity in American society and tries to understand her own relationship with her mother.

  1. AMiBA: Cluster Sunyaev-Zel'dovich Effect Observations with the Expanded 13-Element Array

    CERN Document Server

    Lin, Kai-Yang; Wang, Fu-Cheng; Huang, Chih-Wei Locutus; Liao, Yu-Wei; Wu, Jiun-Huei Proty; Koch, Patrick M; Umetsu, Keiichi; Chen, Ming-Tang; Chan, Shun-Hsiang; Chang, Shu-Hao; Chang, Wen-Hsuan Lucky; Cheng, Tai-An; Duy, Hoang Ngoc; Fu, Szu-Yuan; Han, Chih-Chiang; Ho, Solomon; Ho, Ming-Feng; Ho, Paul T P; Huang, Yau-De; Jiang, Homin; Kubo, Derek Y; Li, Chao-Te; Lin, Yu-Chiung; Liu, Guo-Chin; Martin-Cocher, Pierre; Molnar, Sandor M; Nunez, Emmanuel; Oshiro, Peter; Pai, Shang-Ping; Raffin, Philippe; Ridenour, Anthony; Shih, Chia-You; Stoebner, Sara; Teo, Giap-Siong; Yeh, Jia-Long Johnny; Williams, Joshua; Birkinshaw, Mark

    2016-01-01

    The Yuan-Tseh Lee Array for Microwave Background Anisotropy (AMiBA) is a co-planar interferometer array operating at a wavelength of 3mm to measure the Sunyaev-Zeldovich effect (SZE) of galaxy clusters. In the first phase of operation -- with a compact 7-element array with 0.6m antennas (AMiBA-7) -- we observed six clusters at angular scales from 5\\arcmin to 23\\arcmin. Here, we describe the expansion of AMiBA to a 13-element array with 1.2m antennas (AMiBA-13), its subsequent commissioning, and our cluster SZE observing program. The most important changes compared to AMiBA-7 are (1) array re-configuration with baselines ranging from 1.4m to 4.8m covering angular scales from 2\\arcmin to 11.5\\arcmin, (2) thirteen new lightweight carbon-fiber-reinforced plastic (CFRP) 1.2m reflectors, and (3) additional correlators and six new receivers. From the AMiBA-13 SZE observing program, we present here maps of a subset of twelve clusters. In highlights, we combine AMiBA-7 and AMiBA-13 observations of Abell 1689 and perfo...

  2. Expression, purification and functional characterization of AmiA of acetamidase operon of Mycobacterium smegmatis.

    Science.gov (United States)

    Sundararaman, Balaji; Palaniyandi, Kannan; Venkatesan, Arunkumar; Narayanan, Sujatha

    2014-11-01

    Regulation of gene expression is one of the mechanisms of virulence in pathogenic organisms. In this context, we would like to understand the gene regulation of acetamidase enzyme of Mycobacterium smegmatis, which is the first reported inducible enzyme in mycobacteria. The acetamidase is highly inducible and the expression of this enzyme is increased 100-fold when the substrate acetamide is added. The acetamidase structural gene (amiE) is found immediately downstream of three predicted open reading frames (ORFs). Three of these genes along with a divergently expressed ORF are predicted to form an operon and involved in the regulation of acetamidase enzyme. Here we report expression, purification and functional characterization of AmiA which is one of these predicted ORFs. Electrophoretic mobility shift assays showed that AmiA binds to the region between the amiA and amiD near the predicted promoter (P2). Over-expression of AmiA significantly lowered the expression of acetamidase compared to the wild type as demonstrated by qRT-PCR and SDS-PAGE. We conclude that AmiA binds near P2 promoter and acts as a repressor in the regulation of acetamidase operon. The described work is a further step forward toward broadening the knowledge on understanding of the complex gene regulatory mechanism of Mycobacterium sp.

  3. On Chinese American Identity Dilemma in Amy Tan's The Bonesetter's Daughter

    Institute of Scientific and Technical Information of China (English)

    梁福江

    2010-01-01

    In The Bonesetter's Daughter,Amy Tan explores the complexity of Chinese American identity dilemma confronted by the major charactersThis paper in-tends to examine the marginalized position of the Chinese immigrant mother Luling and the American bom daughter Ruth and reveal the ideology of Amy Tan's writing beyond the bounds of ethnicity.

  4. AmyR is a novel negative regulator of amylovoran production in Erwinia amylovora

    Science.gov (United States)

    We have previously reported the characterization of an orphan gene ybjN from Escherichia coli. In this study, we attempted to understand the role of amyR in Erwinia amylovora, a functionally conserved homolog of E. coli ybjN. As reported earlier, amylovoran production in the amyR knockout mutant is ...

  5. A modified Bowen ratio method to determine sensible and latent heat fluxes

    Directory of Open Access Journals (Sweden)

    Heping Liu

    2001-03-01

    Full Text Available The sensible heat flux (H and the latent heat flux (λE were measured above a grassland during June, 1997 (LINEX-97/1 Experiment, using the eddy covariance method (EC and the Bowen ratio/Energy balance method (BREB. The results indicate that HBREB is about (30 ± 20 Wm-2 higher than HEC, and λEBREB is about (180 ± 40 Wm-2 higher than λEEC during the daytime, and this is mainly caused by an imbalance in the closure of the surface energy balance in the BREB. In order to avoid the inaccuracies associated with the surface energy balance method, we propose a modified Bowen ratio method (MBR to determine sensible and latent heat fluxes without using the surface energy balance equation. The results and error analysis show that MBR can give more accurate results than BREB. For the MBR, a measurement system using a sonic anemometer together with temperature and humidity measurements at two levels is being recommended to obtain sensible and latent heat fluxes.

  6. A Bowen Family Systems Model of Generalized Anxiety Disorder and Romantic Relationship Distress.

    Science.gov (United States)

    Priest, Jacob B

    2015-07-01

    Many individuals with generalized anxiety disorder (GAD) do not respond well to currently available treatments. Moreover, treatments are less effective when GAD is accompanied by romantic relationship distress. In order to develop effective treatments for GAD and relationship distress, it is necessary to conduct theory-based research to identify links common to both GAD and romantic relationship distress. Drawing on Bowen's family systems theory, the roles of family abuse/violence and differentiation in GAD and romantic relationship distress were examined using existing data from the National Comorbidity Survey Replication (n = 2,312; 2005). As predicted, family abuse/violence was directly linked to both GAD and romantic relationship distress. Differentiation mediated the relationship between family abuse/violence and GAD, and partially mediated the relationship between family abuse/violence and romantic relationship distress. Findings suggest that current and past relationship processes may help maintain chronic anxiety and that Bowen's theory may be a useful framework for developing couple therapy treatment of GAD and romantic relationship distress. © 2013 American Association for Marriage and Family Therapy.

  7. Multiscale Convective Interactions During DYNAMO/CINDY2011/AMIE

    Science.gov (United States)

    Schumacher, C.; DePasquale, A. M.; Fliegel, J. M.; Funk, A. B.

    2014-12-01

    Radar and sounding observations are used to examine precipitation, cloud, and environmental characteristics over Addu Atoll from the Dynamics of the Madden-Julian (MJO) Oscillation (DYNAMO), the Cooperative Indian Ocean Experiment on Intraseasonal Variability in the Year 2011 (CINDY2011), and the Atmospheric Radiation Measurement (ARM) Madden-Julian Oscillation Investigation Experiment (AMIE) field campaigns. Particular focus is placed on how the existence of and interactions between three MJO events, 10 Kelvin waves (KWs), and the diurnal cycle impact convective system properties. For example, the average MJO characteristics were generally consistent with past studies, although an increase in deep convective rain and echo tops appeared to precede relative humidity increases at low- to middle-levels. MJO convective organization was also impacted by deep tropospheric wind shear. The active and developing MJO KWs produced more rain and cloud than suppressed MJO KWs and had a secondary peak in stratiform rain potentially associated with subsynoptic-scale cloud clusters. The diurnal cycle of rain was also more pronounced during the active MJO. The suppressed MJO KW composite displayed previously documented structure of vertical moisture buildup prior to the KW passage, whereas the developing and active MJO KWs did not. Upper level moisture was enhanced after KW passages, regardless of MJO phase. However, upper level moisture was most enhanced after the developing MJO KW passage, providing deep tropospheric moisture that may have assisted MJO onset. Non-precipitating upper level cloud and midlevel altocumulus/altostratus also persisted after most KW passages with potential radiative impacts.

  8. AMIE Gan Island Ancillary Disdrometer Field Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Oue, Mariko [Stony Brook Univ., NY (United States)

    2016-04-01

    As part of the U.S. Department of Energy (DOE)’s Atmospheric Radiation Measurement Climate Research Facility (ARM) Madden-Julian Oscillation (MJO) Investigation Experiment (AMIE), in January 2012 a disdrometer observation took place with the second ARM Mobile Facility (AMF2), the Scanning ARM Cloud Radar (SACR), the Texas A&M SMART-R C-band radar, and the National Center for Atmospheric Research (NCAR) dual wavelength S- and Ka-bands polarimetric (SPolKa) radar on Gan Island, Maldives. In order to measure raindrop size distributions, a disdrometer of Nagoya University, Japan, was set up close to the ARM Two-Dimensional (2D) Video Disdrometer (2DVD). The SMART-R and SPolKa radars performed range-height-indicator scanning in the direction of the disdrometer site. Comparing the disdrometer data with 2DVD data, the raindrop size distribution data will be calibrated. Furthermore, the analysis of the raindrop size distribution and radar data will be expected to clarify the microphysics in tropical convective clouds.

  9. Amy63, a novel type of marine bacterial multifunctional enzyme possessing amylase, agarase and carrageenase activities.

    Science.gov (United States)

    Liu, Ge; Wu, Shimei; Jin, Weihua; Sun, Chaomin

    2016-01-04

    A multifunctional enzyme is one that performs multiple physiological functions, thus benefiting the organism. Characterization of multifunctional enzymes is important for researchers to understand how organisms adapt to different environmental challenges. In the present study, we report the discovery of a novel multifunctional enzyme Amy63 produced by marine bacterium Vibrio alginolyticus 63. Remarkably, Amy63 possesses amylase, agarase and carrageenase activities. Amy63 is a substrate promiscuous α-amylase, with the substrate priority order of starch, carrageenan and agar. Amy63 maintains considerable amylase, carrageenase and agarase activities and stabilities at wide temperature and pH ranges, and optimum activities are detected at temperature of 60 °C and pH of 6.0, respectively. Moreover, the heteroexpression of Amy63 dramatically enhances the ability of E. coli to degrade starch, carrageenan and agar. Motif searching shows three continuous glycosyl hydrolase 70 (GH70) family homologs existed in Amy63 encoding sequence. Combining serial deletions and phylogenetic analysis of Amy63, the GH70 homologs are proposed as the determinants of enzyme promiscuity. Notably, such enzymes exist in all kingdoms of life, thus providing an expanded perspective on studies of multifunctional enzymes. To our knowledge, this is the first report of an amylase having additional agarase and carrageenase activities.

  10. Arabidopsis thaliana AMY3 is a unique redox-regulated chloroplastic α-amylase.

    Science.gov (United States)

    Seung, David; Thalmann, Matthias; Sparla, Francesca; Abou Hachem, Maher; Lee, Sang Kyu; Issakidis-Bourguet, Emmanuelle; Svensson, Birte; Zeeman, Samuel C; Santelia, Diana

    2013-11-22

    α-Amylases are glucan hydrolases that cleave α-1,4-glucosidic bonds in starch. In vascular plants, α-amylases can be classified into three subfamilies. Arabidopsis has one member of each subfamily. Among them, only AtAMY3 is localized in the chloroplast. We expressed and purified AtAMY3 from Escherichia coli and carried out a biochemical characterization of the protein to find factors that regulate its activity. Recombinant AtAMY3 was active toward both insoluble starch granules and soluble substrates, with a strong preference for β-limit dextrin over amylopectin. Activity was shown to be dependent on a conserved aspartic acid residue (Asp(666)), identified as the catalytic nucleophile in other plant α-amylases such as the barley AMY1. AtAMY3 released small linear and branched glucans from Arabidopsis starch granules, and the proportion of branched glucans increased after the predigestion of starch with a β-amylase. Optimal rates of starch digestion in vitro was achieved when both AtAMY3 and β-amylase activities were present, suggesting that the two enzymes work synergistically at the granule surface. We also found that AtAMY3 has unique properties among other characterized plant α-amylases, with a pH optimum of 7.5-8, appropriate for activity in the chloroplast stroma. AtAMY3 is also redox-regulated, and the inactive oxidized form of AtAMY3 could be reactivated by reduced thioredoxins. Site-directed mutagenesis combined with mass spectrometry analysis showed that a disulfide bridge between Cys(499) and Cys(587) is central to this regulation. This work provides new insights into how α-amylase activity may be regulated in the chloroplast.

  11. Amy Tan’s View on Cultural Identity in The Joy Luck Club

    Institute of Scientific and Technical Information of China (English)

    YANY Jing; FAN Yuan

    2016-01-01

    In The Joy Luck Club, Amy Tan explores the issue of cultural identity and shows her thoughtful understanding of the mi-nority’s cultural identity. With a series of analysis and elaborations about The Joy Luck Club based upon post-colonial theories, the author of this thesis holds that:in Amy Tan’s opinion, the ethnic cultural identities should not be fixed, single but negotiable and hybrid. Amy Tan’s exploration of the ethnic cultural identity can provide some positive enlightenment for those minorities who are still confused about their cultural identities.

  12. Development of Heart Rate Variaty in the Early and Rehabilitation Phase of AMI

    Institute of Scientific and Technical Information of China (English)

    R. Tanhbalouti; Feng Jianzhang; Feng Xiuhua

    2000-01-01

    Heart rate variaty (HRV) of 85 cases with AMI was observed in the early phase after onset and rehabilitation phase at first month and sixth month, and was contrasted with six time threshold indices of 111 cases with coronary heart disease and that of 35 normal control. We found the HRV of AMI was apperantly lower in the acute phase than that of coronary heart disease and normal controls. HRV recovered gradually with inclining to be stable after half a year, but it was still lower than that of controls. Low HRV in early phase of AMI suggested the poor prognosis.

  13. Testing a model of codependency for college students in Taiwan based on Bowen's concept of differentiation.

    Science.gov (United States)

    Chang, Shih-Hua

    2016-04-01

    The purpose of this study was to test a model of codependency based on Bowen's concept of differentiation for college students in Taiwan. The relations between family-of-origin dysfunction, differentiation of self, codependency traits and related symptoms including low self-esteem, relationship distress and psychological adjustment problems were examined. Data were collected from 567 college students from 2 large, urban universities in northern Taiwan. Results indicated a significantly negative relationship between levels of codependency and self-differentiation and that self-differentiation partially mediated the relationship between family-of-origin dysfunction and codependency. The implications of these findings for counselling Taiwanese college students who experience codependency traits and related symptoms as well as suggestions for future research are discussed. © 2016 International Union of Psychological Science.

  14. Arabidopsis thaliana AMY3 Is a Unique Redox-regulated Chloroplastic α-Amylase

    DEFF Research Database (Denmark)

    Seung, David; Thalmann, Matthias; Sparla, Francesca;

    2013-01-01

    α-Amylases are glucan hydrolases that cleave α-1,4-glucosidic bonds in starch. In vascular plants, α-amylases can be classified into three subfamilies. Arabidopsis has one member of each subfamily. Among them, only AtAMY3 is localized in the chloroplast. We expressed and purified AtAMY3 from......-amylases, with a pH optimum of 7.5–8, appropriate for activity in the chloroplast stroma. AtAMY3 is also redox-regulated, and the inactive oxidized form of AtAMY3 could be reactivated by reduced thioredoxins. Site-directed mutagenesis combined with mass spectrometry analysis showed that a disulfide bridge between...... Cys499 and Cys587 is central to this regulation. This work provides new insights into how α-amylase activity may be regulated in the chloroplast....

  15. Security Analysis of Selected AMI Failure Scenarios Using Agent Based Game Theoretic Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Abercrombie, Robert K [ORNL; Schlicher, Bob G [ORNL; Sheldon, Frederick T [ORNL

    2014-01-01

    Information security analysis can be performed using game theory implemented in dynamic Agent Based Game Theoretic (ABGT) simulations. Such simulations can be verified with the results from game theory analysis and further used to explore larger scale, real world scenarios involving multiple attackers, defenders, and information assets. We concentrated our analysis on the Advanced Metering Infrastructure (AMI) functional domain which the National Electric Sector Cyber security Organization Resource (NESCOR) working group has currently documented 29 failure scenarios. The strategy for the game was developed by analyzing five electric sector representative failure scenarios contained in the AMI functional domain. From these five selected scenarios, we characterize them into three specific threat categories affecting confidentiality, integrity and availability (CIA). The analysis using our ABGT simulation demonstrates how to model the AMI functional domain using a set of rationalized game theoretic rules decomposed from the failure scenarios in terms of how those scenarios might impact the AMI network with respect to CIA.

  16. ARM MJO Investigation Experiment on Gan Island (AMIE-Gan) Science Plan

    Energy Technology Data Exchange (ETDEWEB)

    Long, CL; Del Genio, A; Deng, M; Fu, X; Gustafson, W; Houze, R; Jakob, C; Jensen, M; Johnson, R; Liu, X; Luke, E; May, P; McFarlane, S; Minnis, P; Schumacher, C; Vogelmann, A; Wang, Y; Webster, P; Xie, S; Zhang, C

    2011-04-11

    The overarching campaign, which includes the ARM Mobile Facility 2 (AMF2) deployment in conjunction with the Dynamics of the Madden-Julian Oscillation (DYNAMO) and the Cooperative Indian Ocean experiment on intraseasonal variability in the Year 2011 (CINDY2011) campaigns, is designed to test several current hypotheses regarding the mechanisms responsible for Madden-Julian Oscillation (MJO) initiation and propagation in the Indian Ocean area. The synergy between the proposed AMF2 deployment with DYNAMO/CINDY2011, and the corresponding funded experiment on Manus, combine for an overarching ARM MJO Investigation Experiment (AMIE) with two components: AMF2 on Gan Island in the Indian Ocean (AMIE-Gan), where the MJO initiates and starts its eastward propagation; and the ARM Manus site (AMIE-Manus), which is in the general area where the MJO usually starts to weaken in climate models. AMIE-Gan will provide measurements of particular interest to Atmospheric System Research (ASR) researchers relevant to improving the representation of MJO initiation in climate models. The framework of DYNAMO/CINDY2011 includes two proposed island-based sites and two ship-based locations forming a square pattern with sonde profiles and scanning precipitation and cloud radars at both island and ship sites. These data will be used to produce a Variational Analysis data set coinciding with the one produced for AMIE-Manus. The synergy between AMIE-Manus and AMIE-Gan will allow studies of the initiation, propagation, and evolution of the convective cloud population within the framework of the MJO. As with AMIE-Manus, AMIE-Gan/DYNAMO also includes a significant modeling component geared toward improving the representation of MJO initiation and propagation in climate and forecast models. This campaign involves the deployment of the second, marine-capable, AMF; all of the included measurement systems; and especially the scanning and vertically pointing radars. The campaign will include sonde

  17. Low AMY1 Gene Copy Number Is Associated with Increased Body Mass Index in Prepubertal Boys.

    Directory of Open Access Journals (Sweden)

    M Loredana Marcovecchio

    Full Text Available Genome-wide association studies have identified more than 60 single nucleotide polymorphisms associated with Body Mass Index (BMI. Additional genetic variants, such as copy number variations (CNV, have also been investigated in relation to BMI. Recently, the highly polymorphic CNV in the salivary amylase (AMY1 gene, encoding an enzyme implicated in the first step of starch digestion, has been associated with obesity in adults and children. We assessed the potential association between AMY1 copy number and a wide range of BMI in a population of Italian school-children.744 children (354 boys, 390 girls, mean age (±SD: 8.4±1.4years underwent anthropometric assessments (height, weight and collection of saliva samples for DNA extraction. AMY1 copies were evaluated by quantitative PCR.A significant increase of BMI z-score by decreasing AMY1 copy number was observed in boys (β: -0.117, p = 0.033, but not in girls. Similarly, waist circumference (β: -0.155, p = 0.003, adjusted for age was negatively influenced by AMY1 copy number in boys. Boys with 8 or more AMY1 copy numbers presented a significant lower BMI z-score (p = 0.04 and waist circumference (p = 0.01 when compared to boys with less than 8 copy numbers.In this pediatric-only, population-based study, a lower AMY1 copy number emerged to be associated with increased BMI in boys. These data confirm previous findings from adult studies and support a potential role of a higher copy number of the salivary AMY1 gene in protecting from excess weight gain.

  18. AMI observations of unmatched Planck ERCSC LFI sources at 15.75 GHz

    OpenAIRE

    2011-01-01

    The Planck Early Release Compact Source Catalogue includes 26 sources with no obvious matches in other radio catalogues (of primarily extragalactic sources). Here we present observations made with the Arcminute Microkelvin Imager Small Array (AMI SA) at 15.75 GHz of the eight of the unmatched sources at declination > +10 degrees. Of the eight, four are detected and are associated with known objects. The other four are not detected with the AMI SA, and are thought to be spurious.

  19. Low AMY1 Gene Copy Number Is Associated with Increased Body Mass Index in Prepubertal Boys

    Science.gov (United States)

    Verginelli, Fabio; De Lellis, Laura; Capelli, Cristian; Verzilli, Delfina; Chiarelli, Francesco; Mohn, Angelika; Cama, Alessandro

    2016-01-01

    Background Genome-wide association studies have identified more than 60 single nucleotide polymorphisms associated with Body Mass Index (BMI). Additional genetic variants, such as copy number variations (CNV), have also been investigated in relation to BMI. Recently, the highly polymorphic CNV in the salivary amylase (AMY1) gene, encoding an enzyme implicated in the first step of starch digestion, has been associated with obesity in adults and children. We assessed the potential association between AMY1 copy number and a wide range of BMI in a population of Italian school-children. Methods 744 children (354 boys, 390 girls, mean age (±SD): 8.4±1.4years) underwent anthropometric assessments (height, weight) and collection of saliva samples for DNA extraction. AMY1 copies were evaluated by quantitative PCR. Results A significant increase of BMI z-score by decreasing AMY1 copy number was observed in boys (β: -0.117, p = 0.033), but not in girls. Similarly, waist circumference (β: -0.155, p = 0.003, adjusted for age) was negatively influenced by AMY1 copy number in boys. Boys with 8 or more AMY1 copy numbers presented a significant lower BMI z-score (p = 0.04) and waist circumference (p = 0.01) when compared to boys with less than 8 copy numbers. Conclusions In this pediatric-only, population-based study, a lower AMY1 copy number emerged to be associated with increased BMI in boys. These data confirm previous findings from adult studies and support a potential role of a higher copy number of the salivary AMY1 gene in protecting from excess weight gain. PMID:27149670

  20. Migration of the ATLAS Metadata Interface (AMI) to Web 2.0 and cloud

    Science.gov (United States)

    Odier, J.; Albrand, S.; Fulachier, J.; Lambert, F.

    2015-12-01

    The ATLAS Metadata Interface (AMI), a mature application of more than 10 years of existence, is currently under adaptation to some recently available technologies. The web interfaces, which previously manipulated XML documents using XSL transformations, are being migrated to Asynchronous JavaScript (AJAX). Web development is considerably simplified by the introduction of a framework based on JQuery and Twitter Bootstrap. Finally, the AMI services are being migrated to an OpenStack cloud infrastructure.

  1. Deploying the ATLAS Metadata Interface (AMI) on the cloud with Jenkins.

    CERN Document Server

    Lambert, Fabian; The ATLAS collaboration

    2016-01-01

    The ATLAS Metadata Interface (AMI) is a mature application of more than 15 years of existence. Mainly used by the ATLAS experiment at CERN, it consists of a very generic tool ecosystem for metadata aggregation and cataloguing. AMI is used by the ATLAS production system, therefore the service must guarantee a high level of availability. We describe our monitoring and administration systems and the Jenkins-based strategy used to dynamically test and deploy cloud OpenStack nodes on demand.

  2. Migration of the ATLAS Metadata Interface (AMI) to Web 2.0 and cloud

    CERN Document Server

    Odier, Jerome; The ATLAS collaboration; Fulachier, Jerome; Lambert, Fabian

    2015-01-01

    The ATLAS Metadata Interface (AMI), a mature application of more than 10 years of existence, is currently under adaptation to some recently available technologies. The web interfaces, which previously manipulated XML documents using XSL transformations, are being migrated to Asynchronous JavaScript (AJAX). Web development is considerably simplified by the introduction of a framework based on JQuery and Twitter Bootstrap. Finally, the AMI services are being migrated to an OpenStack cloud infrastructure.

  3. Human papillomavirus infection in Bowen disease: negative p53 expression, not p16(INK4a) overexpression, is correlated with human papillomavirus-associated Bowen disease.

    Science.gov (United States)

    Murao, Kazutoshi; Yoshioka, Rika; Kubo, Yoshiaki

    2014-10-01

    Genital Bowen disease (BD) has been linked to the high-risk types of human papillomavirus (HPV) infection. Recently, it has been recognized that HPV also can be associated with extragenital BD. HPV oncoproteins E6 and E7 interfere with the function of p53 and pRb, respectively, leading carcinogenesis. p16(INK4a) overexpression induced by inactivation of pRb is recognized as a surrogate marker for HPV-associated cervical cancer. In this study, we examined the presence of HPV DNA in 142 BD lesions by polymerase chain reaction (PCR), and determined the type of HPV by PCR restriction fragment length polymorphism or direct DNA sequencing. HPV DNA was detected in 66.7% of genital BD and 8.3% of extragenital BD. The types of HPV detected were HPV types 6, 16, 33, 52, 56, 58 and 59. We also investigated the expression of p16(INK4a) , pRb and p53 by immunohistochemistry. Positive expression was detected in 88.6% for p16(INK4a) , 25.2% for pRb, and 63.8% for p53. There was no significant difference in p16(INK4a) and pRb expression between HPV-positive and -negative BD. However, a strong correlation of HPV positivity with p53 negativity was found. A total of 66.7% of HPV-positive BD showed no p53 expression, whereas the corresponding rate was 32.8% of HPV-negative BD. This study demonstrated that HPV can participate in the development of BD, not only in the genital lesion, but also in extragenital lesion. p16(INK) (4a) overexpression is not a marker for HPV infection in BD. Instead, negative p53 expression is correlated with HPV-associated BD.

  4. AmyA, an alpha-amylase with beta-cyclodextrin-forming activity, and AmyB from the thermoalkaliphilic organism Anaerobranca gottschalkii: two alpha-amylases adapted to their different cellular localizations.

    Science.gov (United States)

    Ballschmiter, Meike; Armbrecht, Martin; Ivanova, Krasimira; Antranikian, Garabed; Liebl, Wolfgang

    2005-07-01

    Two alpha-amylase genes from the thermophilic alkaliphile Anaerobranca gottschalkii were cloned, and the corresponding enzymes, AmyA and AmyB, were investigated after purification of the recombinant proteins. Based on their amino acid sequences, AmyA is proposed to be a lipoprotein with extracellular localization and thus is exposed to the alkaline milieu, while AmyB apparently represents a cytoplasmic enzyme. The amino acid sequences of both enzymes bear high similarity to those of GHF13 proteins. The different cellular localizations of AmyA and AmyB are reflected in their physicochemical properties. The alkaline pH optimum (pH 8), as well as the broad pH range, of AmyA activity (more than 50% activity between pH 6 and pH 9.5) mirrors the conditions that are encountered by an extracellular enzyme exposed to the medium of A. gottschalkii, which grows between pH 6 and pH 10.5. AmyB, on the other hand, has a narrow pH range with a slightly acidic pH optimum at 6 to 6.5, which is presumably close to the pH in the cytoplasm. Also, the intracellular AmyB is less tolerant of high temperatures than the extracellular AmyA. While AmyA has a half-life of 48 h at 70 degrees C, AmyB has a half-life of only about 10 min at that temperature, perhaps due to the lack of stabilizing constituents of the cytoplasm. AmyA and AmyB were very similar with respect to their substrate specificity profiles, clearly preferring amylose over amylopectin, pullulan, and glycogen. Both enzymes also hydrolyzed alpha-, beta-, and gamma-cyclodextrin. Very interestingly, AmyA, but not AmyB, displayed high transglycosylation activity on maltooligosaccharides and also had significant beta-cyclodextrin glycosyltransferase (CGTase) activity. CGTase activity has not been reported for typical alpha-amylases before. The mechanism of cyclodextrin formation by AmyA is unknown.

  5. Verifying the distributed temperature sensing Bowen ratio method for measuring evaporation

    Science.gov (United States)

    Schilperoort, Bart; Coenders-Gerrits, Miriam; Luxemburg, Willem; Cisneros Vaca, César; Ucer, Murat

    2016-04-01

    Evaporation is an important process in the hydrological cycle, therefore measuring evaporation accurately is essential for water resource management, hydrological management and climate change models. Current techniques to measure evaporation, like eddy covariance systems, scintillometers, or lysimeters, have their limitations and therefore cannot always be used to estimate evaporation correctly. Also the conventional Bowen ratio surface energy balance method has as drawback that two sensors are used, which results in large measuring errors. In Euser et al. (2014) a new method was introduced, the DTS-based Bowen ratio (BR-DTS), that overcomes this drawback. It uses a distributed temperature sensing technique (DTS) whereby a fibre optic cable is placed vertically, going up and down along a measurement tower. One stretch of the cable is dry, the other wrapped with cloth and kept wet, akin to a psychrometer. Using this, the wet and dry bulb temperatures are determined every 12.5 cm over the height, from which the Bowen ratio can be determined. As radiation and wind have an effect on the cooling and heating of the cable's sheath as well, the DTS cables do not necessarily always measure dry and wet bulb temperature of the air accurately. In this study the accuracy in representing the dry and wet bulb temperatures of the cable are verified, and evaporation observations of the BR-DTS method are compared to Eddy Covariance (EC) measurements. Two ways to correct for errors due to wind and solar radiation warming up the DTS cables are presented: one for the dry cable and one for the wet cable. The measurements were carried out in a pine forest near Garderen (The Netherlands), along a 46-meter tall scaffold tower (15 meters above the canopy). Both the wet (Twet) and dry (Tdry) temperature of the DTS cable were compared to temperature and humidity (from which Twet is derived) observations from sensors placed along the height of the tower. Underneath the canopy, where there was

  6. Suburban Energy Balance Estimates for Vancouver, B.C., Using the Bowen Ratio-Energy Balance Approach.

    Science.gov (United States)

    Kalanda, B. D.; Oke, T. R.; Spittlehouse, D. L.

    1980-07-01

    The energy balance of a suburban site in Vancouver, B.C. in late summer is presented. The balance is obtained from direct measurements of net radiation, parameterized heat storage and turbulent fluxes determined according to the Bowen ratio-energy balance method with reversing psychrometers. An error analysis shows the turbulent fluxes are good to within 10-20% by day. Features of the suburban energy balance are found to be intermediate between those previously reported for urban and rural surfaces. Average daytime Bowen ratios are usually in the range 0.5-1.0 with some days as high as 2.5. The daytime sensible heat flux is in-phase with the net radiation. At night this flux is sometimes positive. Evapotranspiration is always an important term in the balance. The role of urban irrigation and microscale heat advection in maintaining evapotranspiration rates is discussed.

  7. Spectrophotometry near the atmospheric cutoff of the strongest Bowen resonance fluorescence lines of O III in two planetary nebulae

    Science.gov (United States)

    O'Dell, C. R.; Opal, Chet B.

    1989-01-01

    Spectrophotometric results are presented for the stronger, well-resolved Bowen O III resonance fluorescence emission lines in the planetary nebulae 7027 and NGC 7662 down to and including the intrinsically strong line at 3133 A. These data are combined with results from the IUE atlas of spectra and similar results for the longer wavelength lines by Likkel and Aller (1986) to give the first full coverage of the Bowen lines. Good agreement is found with fluorescence theory for the primary cascade lines, except for the Likkel and Aller results. The efficiency of conversion of the exciting He II Ly-alpha into O III lines is determined, and values comparable to other planetary nebulae are found.

  8. [Detection of human papillomavirus in cutaneous extragenital Bowen's disease in immunocompetent patients].

    Science.gov (United States)

    Lampert, A; Pauwels, C; Duboucher, C; Morel, G; Poveda, J D; Périé, G

    2000-01-01

    A specific link between human papillomavirus (HPV) types 16, 18, 31, and 33 and genital carcinomas and between HPV type 5 and cutaneous extragenital carcinomas in patients with epidermodysplasia verruciformis and renal transplant has been previously found. The aim of this prospective study was to detect HPV in cases of cutaneous extragenital Bowen's disease (BD) from non-immunosuppressed patients. Twelve cases of cutaneous extragenital BD or Bowen's carcinoma (BC), seen in the period 1994-1996 and confirmed by histologic examination, were included in the study. Tissue sections were studied by in situ hybridization with a mixture of HPV DNA probes and specific HPV DNA probes. In addition, study on fresh materiel from 1995 included: Southern blot hybridization with various usual HPV probes (6, 11, 16, 18, 31, 33, 35, 39, 42), polymerase chain reaction (PCR) with hybridization using consensus HPV probes and probes specific for HPV types 6, 11, 16, 18 and 33. In positive samples with conventional PCR, in situ PCR with probes specific for HPV types 6/11 and 16 was performed on tissue sections. In situ hybridization was negative in all the cases. Southern blot hybridization was negative in our 9 studied cases. Three cases studied by consensus PCR were positive. PCR with specific HPV probes revealed positivity on two of these cases: HPV 6 in one, and HPV 16 in another. In situ PCR was positive with a mixed 6/11 HPV probe in the third positive consensus PCR case. Our study revealed the presence of HPV in 3 out of 12 cases of cutaneous extragenital BD and BC. HPV type 16, found in BC of skull, was the most usually found type in the literature. HPV types 6/11, detected in 2 cases, were rarely found in cutaneous extragenital BD and BC and these results are in favor of the oncogenic effect of these virus types. In our study, in situ hybridization and Southern blot hybridization were negative in all the cases; HPV was only found in 3 cases by conventional PCR and in 1 case by

  9. FunBlocks. A Modular Framework for AmI System Development

    Science.gov (United States)

    Baquero, Rafael; Rodríguez, José; Mendoza, Sonia; Decouchant, Dominique; Papis, Alfredo Piero Mateos

    2012-01-01

    The last decade has seen explosive growth in the technologies required to implement Ambient Intelligence (AmI) systems. Technologies such as facial and speech recognition, home networks, household cleaning robots, to name a few, have become commonplace. However, due to the multidisciplinary nature of AmI systems and the distinct requirements of different user groups, integrating these developments into full-scale systems is not an easy task. In this paper we propose FunBlocks, a minimalist modular framework for the development of AmI systems based on the function module abstraction used in the IEC 61499 standard for distributed control systems. FunBlocks provides a framework for the development of AmI systems through the integration of modules loosely joined by means of an event-driven middleware and a module and sensor/actuator catalog. The modular design of the FunBlocks framework allows the development of AmI systems which can be customized to a wide variety of usage scenarios. PMID:23112599

  10. FunBlocks. A Modular Framework for AmI System Development

    Directory of Open Access Journals (Sweden)

    Alfredo Piero Mateos Papis

    2012-07-01

    Full Text Available The last decade has seen explosive growth in the technologies required to implement Ambient Intelligence (AmI systems. Technologies such as facial and speech recognition, home networks, household cleaning robots, to name a few, have become commonplace. However, due to the multidisciplinary nature of AmI systems and the distinct requirements of different user groups, integrating these developments into full-scale systems is not an easy task. In this paper we propose FunBlocks, a minimalist modular framework for the development of AmI systems based on the function module abstraction used in the IEC 61499 standard for distributed control systems. FunBlocks provides a framework for the development of AmI systems through the integration of modules loosely joined by means of an event-driven middleware and a module and sensor/actuator catalog. The modular design of the FunBlocks framework allows the development of AmI systems which can be customized to a wide variety of usage scenarios.

  11. Taste and odor occurrence in Lake William C. Bowen and Municipal Reservoir #1, Spartanburg County, South Carolina

    Science.gov (United States)

    Journey, Celeste; Arrington, Jane M.

    2009-01-01

    The U.S. Geological Survey and Spartanburg Water are working cooperatively on an ongoing study of Lake Bowen and Reservoir #1 to identify environmental factors that enhance or influence the production of geosmin in the source-water reservoirs. Spartanburg Water is using information from this study to develop management strategies to reduce (short-term solution) and prevent (long-term solution) geosmin occurrence. Spartanburg Water utility treats and distributes drinking water to the Spartanburg area of South Carolina. The drinking water sources for the area are Lake William C. Bowen (Lake Bowen) and Municipal Reservoir #1 (Reservoir #1), located north of Spartanburg. These reservoirs, which were formed by the impoundment of the South Pacolet River, were assessed in 2006 by the South Carolina Department of Health and Environmental Control (SCDHEC) as being fully supportive of all uses based on established criteria. Nonetheless, Spartanburg Water had noted periodic taste and odor problems due to the presence of geosmin, a naturally occurring compound in the source water. Geosmin is not harmful, but its presence in drinking water is aesthetically unpleasant.

  12. Complex Copy Number Variation of AMY1 does not Associate with Obesity in two East Asian Cohorts.

    Science.gov (United States)

    Yong, Rita Y Y; Mustaffa, Su'Aidah B; Wasan, Pavandip S; Sheng, Liang; Marshall, Christian R; Scherer, Stephen W; Teo, Yik-Ying; Yap, Eric P H

    2016-07-01

    The human amylase gene locus at chromosome 1p21.1 is structurally complex. This region contains two pancreatic amylase genes, AMY2B, AMY2A, and a salivary gene AMY1. The AMY1 gene harbors extensive copy number variation (CNV), and recent studies have implicated this variation in adaptation to starch-rich diets and in association to obesity for European and Asian populations. In this study, we showed that by combining quantitative PCR and digital PCR, coupled with careful experimental design and calibration, we can improve the resolution of genotyping CNV with high copy numbers (CNs). In two East Asian populations of Chinese and Malay ethnicity studied, we observed a unique non-normal distribution of AMY1 diploid CN genotypes with even:odd CNs ratio of 4.5 (3.3-4.7), and an association between the common AMY2A CN = 2 genotype and odd CNs of AMY1, that could be explained by the underlying haplotypic structure. In two further case-control cohorts (n = 932 and 145, for Chinese and Malays, respectively), we did not observe the previously reported association between AMY1 and obesity or body mass index. Improved methods for accurately genotyping multiallelic CNV loci and understanding the haplotype complexity at the AMY1 locus are necessary for population genetics and association studies.

  13. Health Information Management Leaders and the Practice of Leadership through the Lens of Bowen Theory

    Science.gov (United States)

    Sheridan, Patty Thierry; Watzlaf, Valerie; Fox, Leslie Ann

    2016-01-01

    Even though leadership is one of the most examined topics in the organizational literature, its application in the field of health information management (HIM) has not been studied extensively. This descriptive, mixed-methodology study examined HIM leadership through the lens of Bowen theory. The researchers conducted surveys of HIM directors and managers, administrators and colleagues of HIM leaders, and HIM staff using focus groups, observations of meetings, and face-to-face interviews. Results showed that HIM leaders are valued for HIM expertise in electronic health records, privacy, security, and coding; for being the center or heart of the organization; and for commonly valued leadership behaviors and skills including dependability, strategic planning, project management, listening ability, and fairness. Leadership was seen as a reciprocal process, and a team approach was preferred. Good communication, education, and training on HIM topics were also valued. However, HIM leaders believed that they spend more time on management activities than on leadership activities, although they would prefer the reverse. Future research is needed to examine how HIM leadership can be practiced more consistently in the workplace across different HIM functions. PMID:27134609

  14. Health Information Management Leaders and the Practice of Leadership through the Lens of Bowen Theory.

    Science.gov (United States)

    Sheridan, Patty Thierry; Watzlaf, Valerie; Fox, Leslie Ann

    2016-01-01

    Even though leadership is one of the most examined topics in the organizational literature, its application in the field of health information management (HIM) has not been studied extensively. This descriptive, mixed-methodology study examined HIM leadership through the lens of Bowen theory. The researchers conducted surveys of HIM directors and managers, administrators and colleagues of HIM leaders, and HIM staff using focus groups, observations of meetings, and face-to-face interviews. Results showed that HIM leaders are valued for HIM expertise in electronic health records, privacy, security, and coding; for being the center or heart of the organization; and for commonly valued leadership behaviors and skills including dependability, strategic planning, project management, listening ability, and fairness. Leadership was seen as a reciprocal process, and a team approach was preferred. Good communication, education, and training on HIM topics were also valued. However, HIM leaders believed that they spend more time on management activities than on leadership activities, although they would prefer the reverse. Future research is needed to examine how HIM leadership can be practiced more consistently in the workplace across different HIM functions.

  15. Coal resources of the Cullin-la-ringo, Gindie Creek and Minerva Prospects, southwest Bowen Basin

    Energy Technology Data Exchange (ETDEWEB)

    D' Arcy, R.K. (Department of Resource Industries, Qld. (Australia))

    1990-03-01

    Between 1976 and 1989 the Queensland Department of Mines (now the Department of Resource Industries) drilled 20 widely spaced, fully and partly cored holes in an area south of Emerald between Fairbairn reservoir and Mount Alexander. These holes were drilled to test the coal resource potential of the Permian age Reids Dome beds on the northwestern margin of the Denison Trough, southwest Bowen Basin. Eighteen holes intersected thick coal seams within the Reids Dome beds underlying an area about 8 km wide and 24 km long. Numerous seams up to 11 m thick were intersected at depths ranging from 45 m to 476 m. Analysis indicated these seams to be of high quality, being low ash, low sulphur, high volatile non-coking coal with a high calorific value. The study area has been divided along structural trends into three parts or prospects for the purpose of resource description: Cullin-la-ringo in the north, Gindie Creek in the centre and Minerva in the south. Current borehole spacing in these areas is insufficient to allow more than an inferred estimate of in situ coal resources. A total inferred resource of approximately 3 800 million tonnes in situ has been identified to date. Significant potential exists for further expansion of these resources in the Gindie Creek and Minerva prospects, where little drilling has yet taken place. Some potential for resources amenable to opencut mining is indicated in the Minerva prospect, where areas free of basalt cover have been identified.

  16. Estimating evapotranspiration from a reed bed using the Bowen ratio energy balance method

    Science.gov (United States)

    Peacock, C. E.; Hess, T. M.

    2004-02-01

    An increase in demand for water for agricultural and domestic use, combined with new legislation regarding the water needs of natural habitats, has led to an increased requirement for accurate calculations of hydrological fluxes through wetlands. Evapotranspiration is one of the most important but least well understood fluxes in wetland hydrology. Research has been carried out on Stodmarsh National Nature Reserve in Kent, UK, a Ramsar site containing the largest reed beds in southern England. The objective was to quantify water loss through evapotranspiration on the site to allow more effective management of water levels and maintenance of maximum conservation potential for bird life. The Bowen ratio energy balance approach was employed, which is one of the most accurate ways of measuring evapotranspiration but has been rarely used on reed beds. These measurements were used with Penman-Monteith reference evapotranspiration in order to create crop coefficients. It was found that crop coefficients were inconsistent from day to day but were generally less than unity. The inconsistency was thought to be caused by variations in meteorological conditions: e.g. significant differences in crop coefficients were found between days with high radiation and a dry canopy, compared with days with low radiation and a wet canopy. Canopy interception of precipitation was particularly important, with crop coefficients being significantly higher on wet days, possibly due to the higher rates of evaporation of intercepted water due to the lack of stomatal resistance.

  17. Ligusticum wallichii Extract Inhibited the Expression of IL-1β after AMI in Rats

    Directory of Open Access Journals (Sweden)

    Zhuo Yuan

    2014-01-01

    Full Text Available This study investigated the effects of Ligusticum wallichii on IL-1β expression in myocardium and central nervous system after AMI. AMI rat was administrated with Ligusticum wallichii extract. A series of assays were used to detect the effects of Ligusticum wallichii extract on infarct size, left ventricular ejection fraction, expression of TLR-4, NF-κB, and IL-1β in myocardium, IL-1β expression in serum and hypothalamus, and NPY expression in hypothalamus. We observed that Ligusticum wallichii extract improved the left ventricular ejection fraction and reduced infarct area enlargement after AMI, by inhibiting the expression of IL-1β in myocardium, serum, and hypothalamus. Ligusticum wallichii extract reduced the expression of IL-1β in myocardium by regulating TLR4-NF-κB signaling pathway and inhibited IL-1β in hypothalamus by regulating NPY mRNA expression.

  18. A Power Planning Algorithm Based on RPL for AMI Wireless Sensor Networks.

    Science.gov (United States)

    Miguel, Marcio L F; Jamhour, Edgard; Pellenz, Marcelo E; Penna, Manoel C

    2017-03-25

    The advanced metering infrastructure (AMI) is an architecture for two-way communication between electric, gas and water meters and city utilities. The AMI network is a wireless sensor network that provides communication for metering devices in the neighborhood area of the smart grid. Recently, the applicability of a routing protocol for low-power and lossy networks (RPL) has been considered in AMI networks. Some studies in the literature have pointed out problems with RPL, including sub-optimal path selection and instability. In this paper, we defend the viewpoint that careful planning of the transmission power in wireless RPL networks can significantly reduce the pointed problems. This paper presents a method for planning the transmission power in order to assure that, after convergence, the size of the parent set of the RPL nodes is as close as possible to a predefined size. Another important feature is that all nodes in the parent set offer connectivity through links of similar quality.

  19. amiA is a negative regulator of acetamidase expression in Mycobacterium smegmatis

    Directory of Open Access Journals (Sweden)

    Turner Jane

    2001-08-01

    Full Text Available Abstract Background The acetamidase of Mycobacterium smegmatis is a highly inducible enzyme. Expression of this enzyme is increased 100-fold when the substrate acetamide is present. The acetamidase gene is found immediately downstream of three open reading frames. Two of these are proposed to be involved in regulation. Results We constructed a deletion mutant in one of the upstream ORFs (amiA. This mutant (Mad1 showed a constitutively high level of acetamidase expression. We identified four promoters in the upstream region using a β-galactosidase reporter gene. One of these (P2 was inducible in the wild-type, but was constitutively active in Mad1. Conclusions These results demonstrate that amiA encodes a negative regulatory protein which interacts with P2. Since amiA has homology to DNA-binding proteins, it is likely that it exerts the regulatory effect by binding to the promoter to prevent transcription.

  20. Simulation of Cosmic Microwave Background Polarization Fields for AMiBA Experiment

    CERN Document Server

    Park, C G; Park, Chan-Gyung; Park, Changbom

    2002-01-01

    We have made a topological study of cosmic microwave background (CMB) polarization maps by simulating the AMiBA experiment results. A $\\Lambda$CDM CMB sky is adopted to make mock interferometric observations designed for the AMiBA experiment. CMB polarization fields are reconstructed from the AMiBA mock visibility data using the maximum entropy method. We have also considered effects of Galactic foregrounds on the CMB polarization fields. The genus statistic is calculated from the simulated $Q$ and $U$ polarization maps, where $Q$ and $U$ are Stokes parameters. Our study shows that the Galactic foreground emission, even at low Galactic latitude, is expected to have small effects on the CMB polarization field. Increasing survey area and integration time is essential to detect non-Gaussian signals of cosmological origin through genus measurement.

  1. AMiBA: Cluster Sunyaev-Zel’dovich Effect Observations with the Expanded 13-element Array

    Science.gov (United States)

    Lin, Kai-Yang; Nishioka, Hiroaki; Wang, Fu-Cheng; Locutus Huang, Chih-Wei; Liao, Yu-Wei; Proty Wu, Jiun-Huei; Koch, Patrick M.; Umetsu, Keiichi; Chen, Ming-Tang; Chan, Shun-Hsiang; Chang, Shu-Hao; Lucky Chang, Wen-Hsuan; Cheng, Tai-An; Duy, Hoang Ngoc; Fu, Szu-Yuan; Han, Chih-Chiang; Ho, Solomon; Ho, Ming-Feng; Ho, Paul T. P.; Huang, Yau-De; Jiang, Homin; Kubo, Derek Y.; Li, Chao-Te; Lin, Yu-Chiung; Liu, Guo-Chin; Martin-Cocher, Pierre; Molnar, Sandor M.; Nunez, Emmanuel; Oshiro, Peter; Pai, Shang-Ping; Raffin, Philippe; Ridenour, Anthony; Shih, Chia-You; Stoebner, Sara; Teo, Giap-Siong; Yeh, Jia-Long Johnny; Williams, Joshua; Birkinshaw, Mark

    2016-10-01

    The Yuan-Tseh Lee Array for Microwave Background Anisotropy (AMiBA) is a co-planar interferometer array operating at a wavelength of 3 mm to measure the Sunyaev-Zel’dovich effect (SZE) of galaxy clusters at arcminute scales. The first phase of operation—with a compact 7-element array with 0.6 m antennas (AMiBA-7)—observed six clusters at angular scales from 5\\prime to 23\\prime . Here, we describe the expansion of AMiBA to a 13-element array with 1.2 m antennas (AMiBA-13), its subsequent commissioning, and cluster SZE observing program. The most noticeable changes compared to AMiBA-7 are (1) array re-configuration with baselines ranging from 1.4 m to 4.8 m, allowing us to sample structures between 2\\prime and 10\\prime , (2) 13 new lightweight carbon-fiber-reinforced plastic (CFRP) 1.2 m reflectors, and (3) additional correlators and six new receivers. Since the reflectors are co-mounted on and distributed over the entire six-meter CFRP platform, a refined hexapod pointing error model and phase error correction scheme have been developed for AMiBA-13. These effects—entirely negligible for the earlier central close-packed AMiBA-7 configuration—can lead to additional geometrical delays during observations. Our correction scheme recovers at least 80 ± 5% of the point-source fluxes. We, therefore, apply an upward correcting factor of 1.25 to our visibilities to correct for phase decoherence, and a ±5% systematic uncertainty is added in quadrature with our statistical errors. We demonstrate the absence of further systematics with a noise level consistent with zero in stacked uv-visibilities. From the AMiBA-13 SZE observing program, we present here maps of a subset of 12 clusters with signal-to-noise ratios above five. We demonstrate combining AMiBA-7 with AMiBA-13 observations on Abell 1689, by jointly fitting their data to a generalized Navarro-Frenk-White model. Our cylindrically integrated Compton-y values for five radii are consistent with results from

  2. Carrier attitude test system based on AMI 602 sensor%基于AMI 602传感器的载体姿态测试系统

    Institute of Scientific and Technical Information of China (English)

    荆雷; 陈志保; 常丹华; 朱绍图

    2012-01-01

    针对捷联式载体姿态测试系统中存在的抗干扰能力差、不能很好地消除坐标误差以及姿态角测量范围的局限性等缺陷,提出了一种基于集加速度、地磁于一体的6维AMI 602动作传感器的姿态测试系统.通过AMI 602动作传感器输出6维数据结合加速度和地磁2个常量来确定载体在空间中的姿态.测试表明:该系统能解决上述缺陷,且具有精度高、功耗低、小型化等特点,可应用于GPS、手机、游戏设备等姿态测量领域.%Aiming at the defects of poor anti-interference ability,coordinate errors cat not be eliminated,limitation of attitude angle measurement range and so on, which exist in strapdown carrier attitude lest system is proposed. This system is a 6D AMI 602 motion sensor which incorporates geomagnetism and acceleration. The attitude of carrier in the space is determined through the output 6D datas of AMI 602 motion sensor incorporates with the two constants of acceleration and geomagnetism. Tests show that the system can solve ihe above deficiencies and has the characteristics of high precision, low power consumption and miniaturization,can be applied to GPS, mobile phones, game devices and other areas of attitude measurement.

  3. Migration of the ATLAS Metadata Interface (AMI) to Web 2.0 and cloud

    CERN Document Server

    Odier, Jerome; The ATLAS collaboration; Fulachier, Jerome; Lambert, Fabian

    2015-01-01

    The ATLAS Metadata Interface (AMI) can be considered to be a mature application because it has existed for at least 10 years. Over the last year, we have been adapting the application to some recently available technologies. The web interface, which previously manipulated XML documents using XSL transformations, has been migrated to Asynchronous Java Script (AJAX). Web development has been considerably simplified by the development of a framework for AMI based on JQuery and Twitter Bootstrap. Finally there has been a major upgrade of the python web service client.

  4. Deploying the ATLAS Metadata Interface (AMI) on the cloud with Jenkins

    CERN Document Server

    Lambert, Fabian; The ATLAS collaboration

    2016-01-01

    The ATLAS Metadata Interface (AMI) is a mature application of more than 15 years of existence. Mainly used by the ATLAS experiment at CERN, it consists of a very generic tool ecosystem for metadata aggregation and cataloguing. AMI is used by the ATLAS production system, therefore the service must guarantee a high level of availability. We describe our monitoring system and the Jenkins-based strategy used to dynamically test and deploy cloud OpenStack nodes on demand. Moreover, we describe how to switch to a distant replica in case of downtime.

  5. Low Rate of Detection of Mucosal High-Risk-Type Human Papillomavirus in Korean Patients with Extragenital Bowen's Disease and Squamous Cell Carcinoma, Especially in Digital Cases

    Directory of Open Access Journals (Sweden)

    Hye-Rim Park

    2013-01-01

    Full Text Available Human papillomavirus (HPV infection has been demonstrated in some of the nonmelanoma skin cancers as well as in precancerous lesions. Multiple infections of mucosal high-risk HPV may contribute to the onset of digital Bowen's disease through, if any, digital-genital transmission. We screened for the presence of the mucosal HPV DNA in patients with extragenital Bowen's disease (, squamous cell carcinoma (, bowenoid papulosis (, verrucous carcinoma (, actinic keratosis (, and basal cell carcinoma (. We used a PANArray HPV Genotyping Chip for high-risk and low-risk mucosal types. Genotyping data was confirmed using a conventional direct DNA sequencing method. Two cases of extragenital Bowen's disease were positive for types 16 and 33 of mucosal HPV, respectively. None of the squamous cell carcinoma cases were positive. Neither patients with digital Bowen's disease ( nor those with squamous cell carcinoma ( showed any mucosal high-risk HPV. Mucosal high-risk HPV DNA was confirmed in 5 (55.6% of the 9 patients with bowenoid papulosis. HPV 16 was most prevalent (, while the DNA of HPVs 35 and 67 was detected in one sample for each of the two types. Our study demonstrated that two (6.7% of the patients with 30 extragenital Bowen's disease were positive for types 16 and 33 of mucosal HPV, respectively. HPVs belonging to the mucosal high-risk group may participate in the development of extragenital Bowen's disease. However, we could not find any relationship between the mucosal high-risk HPV and Bowen's disease or squamous cell carcinoma in the fingers.

  6. Amylase activity is associated with AMY2B copy numbers in dog: implications for dog domestication, diet and diabetes.

    Science.gov (United States)

    Arendt, Maja; Fall, Tove; Lindblad-Toh, Kerstin; Axelsson, Erik

    2014-10-01

    High amylase activity in dogs is associated with a drastic increase in copy numbers of the gene coding for pancreatic amylase, AMY2B, that likely allowed dogs to thrive on a relatively starch-rich diet during early dog domestication. Although most dogs thus probably digest starch more efficiently than do wolves, AMY2B copy numbers vary widely within the dog population, and it is not clear how this variation affects the individual ability to handle starch nor how it affects dog health. In humans, copy numbers of the gene coding for salivary amylase, AMY1, correlate with both salivary amylase levels and enzyme activity, and high amylase activity is related to improved glycemic homeostasis and lower frequencies of metabolic syndrome. Here, we investigate the relationship between AMY2B copy numbers and serum amylase activity in dogs and show that amylase activity correlates with AMY2B copy numbers. We then describe how AMY2B copy numbers vary in individuals from 20 dog breeds and find strong breed-dependent patterns, indicating that the ability to digest starch varies both at the breed and individual level. Finally, to test whether AMY2B copy number is strongly associated with the risk of developing diabetes mellitus, we compare copy numbers in cases and controls as well as in breeds with varying diabetes susceptibility. Although we see no such association here, future studies using larger cohorts are needed before excluding a possible link between AMY2B and diabetes mellitus.

  7. Amylase activity is associated with AMY2B copy numbers in dog: implications for dog domestication, diet and diabetes

    Science.gov (United States)

    Arendt, Maja; Fall, Tove; Lindblad-Toh, Kerstin; Axelsson, Erik

    2014-01-01

    High amylase activity in dogs is associated with a drastic increase in copy numbers of the gene coding for pancreatic amylase, AMY2B, that likely allowed dogs to thrive on a relatively starch-rich diet during early dog domestication. Although most dogs thus probably digest starch more efficiently than do wolves, AMY2B copy numbers vary widely within the dog population, and it is not clear how this variation affects the individual ability to handle starch nor how it affects dog health. In humans, copy numbers of the gene coding for salivary amylase, AMY1, correlate with both salivary amylase levels and enzyme activity, and high amylase activity is related to improved glycemic homeostasis and lower frequencies of metabolic syndrome. Here, we investigate the relationship between AMY2B copy numbers and serum amylase activity in dogs and show that amylase activity correlates with AMY2B copy numbers. We then describe how AMY2B copy numbers vary in individuals from 20 dog breeds and find strong breed-dependent patterns, indicating that the ability to digest starch varies both at the breed and individual level. Finally, to test whether AMY2B copy number is strongly associated with the risk of developing diabetes mellitus, we compare copy numbers in cases and controls as well as in breeds with varying diabetes susceptibility. Although we see no such association here, future studies using larger cohorts are needed before excluding a possible link between AMY2B and diabetes mellitus. PMID:24975239

  8. Chicks in Charge: Andrea Baker & Amy Daniels--Airport High School Media Center, Columbia, SC

    Science.gov (United States)

    Library Journal, 2004

    2004-01-01

    This article briefly discusses two librarians exploration of Linux. Andrea Baker and Amy Daniels were tired of telling their students that new technology items were not in the budget. They explored Linux, which is a program that recycles older computers, installs free operating systems and free software.

  9. Voltage Harmonics Monitoring in a Microgrid Based on Advanced Metering Infrastructure (AMI)

    DEFF Research Database (Denmark)

    Firoozabadi, Mehdi Savaghebi; Guan, Yajuan; Quintero, Juan Carlos Vasquez

    2015-01-01

    Smart meters are the main part of Advanced Metering Infrastructure (AMI) and are usually able to provide detailed information on customers’ energy consumptions, voltage variations and interruptions. In addition, these meters are potentially able to provide more information about power quality (PQ...

  10. AmI in good care? Developing design principles for ambient intelligent domotics for elderly

    NARCIS (Netherlands)

    Meulendijk, Michiel; van de Wijngaert, Lidwien; Brinkkemper, Sjaak; Leenstra, Herbert

    2011-01-01

    The combination of ambient intelligence (AmI) and domotics has the potential to respond to elderly people's desire to live independent from extensive forms of care. Their slow adoption of technological aids shows reluctance, though. This article investigates their motivations to adopt ambient

  11. Regional Bowen ratio controls on afternoon moist convection: A large eddy simulation study

    Science.gov (United States)

    Kang, Song-Lak

    2016-12-01

    This study examines the effect of the regional Bowen ratio β, the ratio of the domain-averaged surface sensible heat flux (SHF) to latent heat flux (LHF), on afternoon moist convection. With a temporally evolving but spatially uniform surface available energy over a mesoscale domain under a weak capping inversion, we run large eddy simulation of the afternoon convective boundary layer (CBL). We first prescribe a small β of 0.56 (a wet surface) and then the reversed large β of 1.80 (a dry surface) by switching the SHF and LHF fields. The perturbation fields of the fluxes are prescribed with the Fourier spectra of κ- 3 (κ is horizontal wave number; strong mesoscale heterogeneity) and κ0 (homogeneity). The large β cases have strong vertical buoyancy fluxes and produce more vigorous updrafts. In the heterogeneous, large β surface case, with the removal of convective inhibition over a mesoscale subdomain of large SHF, deep convection develops. In the heterogeneous, small β surface case, convective clouds develop but do not progress into precipitating convection. In the homogeneous surface cases, randomly distributed shallow clouds develop with significantly more and thicker clouds in the large β case. (Co)spectral analyses confirm the more vigorous turbulent thermals in the large β cases and reveal that the moisture advection by the surface heterogeneity-induced mesoscale flows makes the correlation between mesoscale temperature and moisture perturbations change from negative to positive, which facilitates the mesoscale pool of high relative humidity air just above the CBL top, a necessary condition for deep convection.

  12. Evaluation of rock mass classification schemes: a case study from the Bowen Basin, Australia

    Science.gov (United States)

    Brook, Martin; Hebblewhite, Bruce; Mitra, Rudrajit

    2016-04-01

    The development of an accurate engineering geological model and adequate knowledge of spatial variation in rock mass conditions are important prerequisites for slope stability analyses, tunnel design, mine planning and risk management. Rock mass classification schemes such as Rock Mass Rating (RMR), Coal Mine Roof Rating (CMRR), Q-system and Roof Strength Index (RSI) have been used for a range of engineering geological applications, including transport tunnels, "hard rock" mining and underground and open-cut coal mines. Often, rock mass classification schemes have been evaluated on subaerial exposures, where weathering has affected joint characteristics and intact strength. In contrast, the focus of this evaluation of the above classification schemes is an underground coal mine in the Bowen Basin, central Queensland, Australia, 15 km east of the town of Moranbah. Rock mass classification was undertaken at 68 sites across the mine. Both the target coal seam and overlying rock show marked spatial variability in terms of RMR, CMRR and Q, but RSI showed limited sensitivity to changes in rock mass condition. Relationships were developed between different parameters with varying degrees of success. A mine-wide analysis of faulting was undertaken, and compared with in situ stress field and local-scale measurements of joint and cleat. While there are no unequivocal relationships between rock mass classification parameters and faulting, a central graben zone shows heterogeneous rock mass properties. The corollary is that if geological features can be accurately defined by remote sensing technologies, then this can assist in predicting rock mass conditions and risk management ahead of development and construction.

  13. Human Papillomavirus Infection and p16 Expression in Extragenital/Extraungual Bowen Disease in Immunocompromised Patients.

    Science.gov (United States)

    Švajdler, Marián; Mezencev, Roman; Kašpírková, Jana; Kacerovská, Denisa; Kazakov, Dmitry V; Ondič, Ondrej; Michal, Michal

    2016-10-01

    An increased rate of second nonmelanoma skin cancers is found in immunocompromised patients. Epidemiological and molecular data implicate ultraviolet radiation as the major risk factor. In addition, there is increasing evidence supporting the role of human papillomavirus (HPV) in the pathogenesis of premalignant and malignant skin lesions in both immunocompetent and immunocompromised patients. In a retrospective cross-sectional study, the authors examined the expression of p16 by immunohistochemistry and the presence of mucosal (α-genus) and cutaneous/epidermodysplasia verruciformis (β-genus) HPV DNA by polymerase chain reaction in 29 biopsy specimens of extragenital/extraungual Bowen disease (BD) from 24 Eastern European white immunocompromised patients. Furthermore, the author evaluated the association between the expression of p16 protein and the presence of HPV DNA. Among 25 specimens from 21 patients evaluable by polymerase chain reaction, HPV DNA was detected in 10 (40%) BD lesions from 9 patients. Beta-HPV predominated over alpha-HPV types. Among 29 immunohistochemically evaluable BD specimens, 22 lesions (∼76%) from 20 patients were scored as p16 positive. HPV DNA-positive and HPV DNA-negative lesions displayed the same proportion of p16 positivity (80%) and no correlation was found between the HPV DNA presence and the p16 expression status. Our pilot study demonstrated that β-HPV infections predominate in BD cases diagnosed among immunocompromised patients, although high- and low-risk mucosal (alpha) HPV genotypes may be detected in a minority of cases. In contrast to anogenital HPV-associated lesions, positive p16 expression is not a reliable marker of high-risk α-HPV infection in BD cases, as it can be also detected in β-HPV infected and HPV-negative cases.

  14. High Resolution Maps of the Moon Surface with AMIE/SMART-1

    Science.gov (United States)

    Despan, Daniela; Erard, S.; Barucci, A.; Josset, J. L.; Beauvivre, S.; Chevrel, S.; Pinet, P.; Koschny, D.; Almeida, M.; Grieger, B.; Foing, B.; AMIE Team

    2008-09-01

    The Advanced Moon micro-Imager Experiment (AMIE) on board the ESA lunar mission Smart-1 has performed colour imaging of the lunar surface using various filters in the visible and NIR range. This micro-camera provided high resolution images of selected parts of the lunar surface, including the North and South pole areas. Being give that the SMART-1 mission was in a 300km x 300km orbit with perilune over the South pole, the coverage between the North and the South regions is different. The AMIE images were obtained using a tele-objective with 5.3° x 5.3° field of view and a sensor of 1024 x 1024 pixels. The output images have resolution 45m/pixel at 500km, and are encoded with 10 bits/pixel. The data for the North pole were obtained at a much higher altitude than the South pole data. From the 300 Km pericenter altitude, the same field of view corresponds to a spatial resolution about 27 m/pixel. The high resolution imaging of the Moon surface makes possible detailed analysis of the morphological features and physical characteristics of the lunar surface. In order to construct AMIE data maps, systematic analysis and processing is being carried on using the whole data set. Geometrical analysis of AMIE images relies on the SPICE system: image coordinates are computed to get precise projection at the surface, and illumination angles are computed to analyze the photometric sequences. Using this method, high resolution mosaics were constructed then compared to lower resolution Clementine UV-Vis and NIR images. Maps of both North and South pole were obtained as well as other regions of interest. Eventually, this method will be applied in all areas where AMIE has provided high resolution observations of the surface, typically a factor of 3 higher than the Clementine UV-Vis camera. New results will be presented at the conference.

  15. Medium dependent dual turn on/turn off fluorescence sensing for Cu2 + ions using AMI/SDS assemblies

    Science.gov (United States)

    Gujar, Varsha B.; Ottoor, Divya

    2017-02-01

    Behavior of Amiloride (AMI) as a metal ion sensor in anionic surfactant assemblies of varying concentrations at different pH is depicted in this work. From a non-sensor fluorophore, AMI has been transformed in to a tunable fluorosensor for Cu2 + ions in various SDS concentrations. At premicellar concentration of SDS, ion-pair complex is expected to be formed between AMI and SDS due to electrostatic interactions between them. However at CMC concentrations of SDS, fluorescence intensity of AMI is greatly enhanced with red shift in emission, due to the incorporation of AMI molecule in the hydrophobic micellar interface. The behavior of metal sensing by AMI-SDS assemblies gives rise to several interesting observations. Micellation of SDS has been greatly enhanced by increasing copper ion concentrations, as these counter ions screens the charge on monomers of SDS which lead to the aggregation at premicellar concentrations only. Concentrations and pH dependent discrete trends of interactions between SDS-AMI and SDS-Cu2 + ions, have given tunable fluorescence responses (fluorescence turn on/turn off) of AMI for added Cu2 + ions. The electrostatic interaction between the metal cations and the anionic surfactants is the driving force for bringing the metal ions near to the vicinity of micelle where AMI resides. Thus, a comprehensive understanding of the mechanism related to the 'turn on-turn off' fluorescence response of AMI with respect to pH and SDS concentration for effective Cu2 + ion sensing is illustrated in this work.

  16. Non-redundant Aperture Masking Interferometry (AMI) and segment phasing with JWST-NIRISS

    Science.gov (United States)

    Sivaramakrishnan, Anand; Lafrenière, David; Ford, K. E. Saavik; McKernan, Barry; Cheetham, Anthony; Greenbaum, Alexandra Z.; Tuthill, Peter G.; Lloyd, James P.; Ireland, Michael J.; Doyon, René; Beaulieu, Mathilde; Martel, André; Koekemoer, Anton; Martinache, Frantz; Teuben, Peter

    2012-09-01

    The Aperture Masked Interferometry (AMI) mode on JWST-NIRISS is implemented as a 7-hole, 15% throughput, non-redundant mask (NRM) that operates with 5-8% bandwidth filters at 3.8, 4.3, and 4.8 microns. We present refined estimates of AMI's expected point-source contrast, using realizations of noise matched to JWST pointing requirements, NIRISS detector noise, and Rev-V JWST wavefront error models for the telescope and instrument. We describe our point-source binary data reduction algorithm, which we use as a standardized method to compare different observational strategies. For a 7.5 magnitude star we report a 10-a detection at between 8.7 and 9.2 magnitudes of contrast between 100 mas to 400 mas respectively, using closure phases and squared visibilities in the absence of bad pixels, but with various other noise sources. With 3% of the pixels unusable, the expected contrast drops by about 0.5 magnitudes. AMI should be able to reach targets as bright as M=5. There will be significant overlap between Gemini-GPI and ESO-SPHERE targets and AMI's search space, and a complementarity with NIRCam's coronagraph. We also illustrate synthesis imaging with AMI, demonstrating an imaging dynamic range of 25 at 100 mas scales. We tailor existing radio interferometric methods to retrieve a faint bar across a bright nucleus, and explain the similarities to synthesis imaging at radio wavelengths. Modest contrast observations of dusty accretion flows around AGNs will be feasible for NIRISS AMI. We show our early results of image-plane deconvolution as well. Finally, we report progress on an NRM-inspired approach to mitigate mission-level risk associated with JWST's specialized wavefront sensing hardware. By combining narrow band and medium band Nyquist-sampled images taken with a science camera we can sense JWST primary mirror segment tip-tilt to lOmas, and piston to a few nm. We can sense inter-segment piston errors of up to 5 coherence lengths of the broadest bandpass filter used

  17. AMIE SMART-1: review of results and legacy 10 years after launch

    Science.gov (United States)

    Josset, Jean-Luc; Souchon, Audrey; Josset, Marie; Foing, Bernard

    2014-05-01

    The Advanced Moon micro-Imager Experiment (AMIE) camera was launched in September 2003 onboard the ESA SMART-1 spacecraft. We review the technical characteristics, scientific objectives and results of the instrument, 10 years after its launch. The AMIE camera is an ultra-compact imaging system that includes a tele-objective with a 5.3° x 5.3° field of view and an imaging sensor of 1024 x 1024 pixels. It is dedicated to spectral imaging with three spectral filters (750, 915 and 960 nm filters), photometric measurements (filter free CCD area), and Laser-link experiment (laser filter at 847 nm). The AMIE camera was designed to acquire high-resolution images of the lunar surface, in white light and for specific spectral bands, under a number of different viewing conditions and geometries. Specifically, its main scientific objectives included: (i) imaging of high latitude regions in the southern hemisphere, in particular the South Pole Aitken basin and the permanently shadowed regions close to the South Pole; (ii) determination of the photometric properties of the lunar surface from observations at different phase angles (physical properties of the regolith); (iii) multi-band imaging for constraining the chemical and mineral composition of the surface; (iv) detection and characterisation of lunar non-mare volcanic units; (v) study of lithological variations from impact craters and implications for crustal heterogeneity. The study of AMIE images enhanced the knowledge of the lunar surface, in particular regarding photometric modelling and surface physical properties of localized lunar areas and geological units. References: http://scholar.google.nl/scholar?q=smart-1+amie We acknowledge ESA, member states, industry and institutes for their contribution, and the members of the AMIE Team: J.-L. Josset, P. Plancke, Y. Langevin, P. Cerroni, M. C. De Sanctis, P. Pinet, S. Chevrel, S. Beauvivre, B.A. Hofmann, M. Josset, D. Koschny, M. Almeida, K. Muinonen, J. Piironen, M. A

  18. The Rising Cost of Higher Education: Charles Eliot's "Free Money" Strategy and the Beginning of Howard Bowen's "Revenue Theory of Cost," 1869-1979

    Science.gov (United States)

    Kimball, Bruce A.

    2014-01-01

    In order to explain the rising cost of higher education, economist Howard Bowen in 1980 proposed his "famous law" of institutional finance. Bowen based his "revenue theory of cost" on a study of aggregate quantitative data extending from 1929 to 1979. Neither he nor subsequent economists asked whether or how that…

  19. Validating Evapotranspiraiton Equations Using Bowen Ratio in New Brunswick, Maritime, Canada.

    Science.gov (United States)

    Xing, Zisheng; Chow, Lien; Meng, Fan-Rui; Rees, Herb W; Steve, Lionel; Monteith, John

    2008-01-24

    Three methods including the Penman-Monteith (PM), Priestley-Taylor (PT), and 1963 Penman equation (PE) for calculating daily reference evapotranspiration (ETo) were evaluated in the Maritime region of Canada with the data collected from 2004 to 2007. An automatically operated meteorological station located on the Potato Research Centre, Agriculture and Agri-Food Canada, Fredericton, New Brunswick, Canada, was used to collect required meteorological data for evapotranspiration modeling. A Bowen Ratio system (BR) was setup near the Environment Canada grade one weather station to provide evapotranspiration observations for the validation research of reference evapotranspiration models. The results showed that the prediction from each of the tested models had a certain degree of offset in comparison with the observations obtained by the BR method. All of the tested models slightly overestimated evapotranspiration compared to the BR system by 5-14%, depending on the method. However, the PM generated a better fit to the pooled dataset while the PT produced the best prediction for the 2007 validation dataset. The PM generated the best estimation of evapotranspiration for year 2004 during a inter-annual comparison. The BR revealed that the average daytime ET for the site was around 2.5 mm day(-1)(±0.1) averaged for Julian day 157-276 in 2004 to 2006 and possible condensation was 0.16 mm day(-1) for the same period. Crop coefficient (Kc) varied with different models, for example, 0.42 for the PM, 0.44 for the PT, and 0.67 for the PE with a slight yearly variation. With this set of Kc values, a validation with additional dataset collected in 2007 indicated that all three equations achieved a good fit with observations using the above Kc values. The PT performed slightly better than the other two models. A single factor analysis did not show any statistically significant difference between predicted and measured ET. With a consideration of simplicity and application for

  20. Validating Evapotranspiraiton Equations Using Bowen Ratio in New Brunswick, Maritime, Canada

    Directory of Open Access Journals (Sweden)

    John Monteith

    2008-01-01

    Full Text Available Three methods including the Penman-Monteith (PM, Priestley-Taylor (PT, and 1963 Penman equation (PE for calculating daily reference evapotranspiration (ETo were evaluated in the Maritime region of Canada with the data collected from 2004 to 2007. An automatically operated meteorological station located on the Potato Research Centre, Agriculture and Agri-Food Canada, Fredericton, New Brunswick, Canada, was used to collect required meteorological data for evapotranspiration modeling. A Bowen Ratio system (BR was setup near the Environment Canada grade one weather station to provide evapotranspiration observations for the validation research of reference evapotranspiration models. The results showed that the prediction from each of the tested models had a certain degree of offset in comparison with the observations obtained by the BR method. All of the tested models slightly overestimated evapotranspiration compared to the BR system by 5-14%, depending on the method. However, the PM generated a better fit to the pooled dataset while the PT produced the best prediction for the 2007 validation dataset. The PM generated the best estimation of evapotranspiration for year 2004 during a inter-annual comparison. The BR revealed that the average daytime ET for the site was around 2.5 mm day-1(±0.1 averaged for Julian day 157-276 in 2004 to 2006 and possible condensation was 0.16 mm day-1 for the same period. Crop coefficient (Kc varied with different models, for example, 0.42 for the PM, 0.44 for the PT, and 0.67 for the PE with a slight yearly variation. With this set of Kc values, a validation with additional dataset collected in 2007 indicated that all three equations achieved a good fit with observations using the above Kc values. The PT performed slightly better than the other two models. A single factor analysis did not show any statistically significant difference between predicted and measured ET. With a consideration of simplicity and

  1. Photodynamic therapy in combination with CO2 laser for the treatment of Bowen's disease.

    Science.gov (United States)

    Cai, Hong; Wang, Yi-xia; Zheng, Ji-Chun; Sun, Ping; Yang, Zhi-yong; Li, Yuan-li; Liu, Xiao-yong; Li, Qiang; Liu, Wei

    2015-07-01

    Photodynamic therapy (PDT) involves the activation of a previously administered photosensitizing agent by visible light to induce tumor necrosis. Photosensitizers are topically applied in the treatment of skin tumors to avoid systemic side effects. In this study, we evaluated the feasibility and efficacy of aminolevulinic acid (ALA) as a photosensitizer (ALA-PDT) in combination with CO2 laser in the treatment of Bowen's disease (BD; intraepithelial squamous cell carcinoma). Twenty-two lesions from 18 patients were randomized into two groups: 11 lesions were treated with topical ALA-PDT (180 J/cm(2) at 100 mW/cm(2)) + CO2 laser for one to three sessions. The remaining 11 lesions were treated with CO2 laser alone, serving as control group. All patients were reviewed at ≤1-week intervals. Biopsies were taken from BD lesions prior to treatment. The initial evaluation was undertaken 1 month after treatment, and biopsies were harvested for histological evaluation. Patients who did not respond to the three sessions of treatment were referred to surgical treatment. In the ALA-PDT + CO2 laser group, 72.73 % (8/11) of BD lesions showed complete remission, with an overall clearance of 90.91 %, and only one recurred (9 %) during follow-up. Local side effects included mild erythema, edema, erosion, and burning and/or stinging sensation. No systemic side effects were observed. In the control group, 63.63 % (7/11) of lesions had complete remission and the overall clearance was 54.55 %. However, five lesions (45.45 %) had recurrence. Local side effects included mild to moderate edema, erosion, ulceration, delayed healing, prolonged pain, and scarring. There existed a significant difference in recurrence rate between the two groups (P laser treatment, complete necrosis was observed in responsive lesions, and 3 months later, the atypical BD cells were replaced by normal keratinocytes. Topical ALA-PDT in combination with CO2 laser is safe, effective, and is

  2. O efeito agudo da terapia Bowen no limiar de dor e controlo postural em indivíduos saudáveis

    OpenAIRE

    Félix, Gonçalo José Silva

    2014-01-01

    Introdução: A fáscia é tecido conjuntivo inervado por terminações nervosas livres e por mecanoretores, tendo um papel importante na dor e na proprioceção. Acredita-se que a Terapia Bowen estimule os mecanorecetores e as terminações nervosas livres presentes na fáscia. Objetivos: Determinar o efeito imediato da Terapia Bowen no limiar de dor à pressão mecânica e no controlo postural em indivíduos saudáveis. Métodos: Este foi um estudo cruzado de amostras emparelhadas, duplamente cego, constitu...

  3. No gender differences in prognosis and preventive treatment in patients with AMI without significant stenoses

    DEFF Research Database (Denmark)

    Hansen, Kim Wadt; Hvelplund, Anders; Abildstrøm, Steen Zabell

    2012-01-01

    Objective: To investigate possible gender differences in patients with acute myocardial infarction (AMI) and without significant stenoses on coronary angiography (CAG) regarding prognosis and use of secondary preventive medication. Design: Nationwide register-based cohort study. Patients: By comp......Objective: To investigate possible gender differences in patients with acute myocardial infarction (AMI) and without significant stenoses on coronary angiography (CAG) regarding prognosis and use of secondary preventive medication. Design: Nationwide register-based cohort study. Patients...... a prescription for a lipid-lowering drug, beta-blocker, clopidogrel, or aspirin within 60 days of discharge. Results: During follow-up, 97 women and 60 men died, resulting in a crude female/male hazard ratio (HR) of 1.51 (95% CI 1.09-2.08). After adjustment for age, time-period, and comorbidity, the gender...

  4. A Study of Ethnocentrism and its Dysfunction in Amy Tan’s The Joy Luck Club

    Institute of Scientific and Technical Information of China (English)

    王真

    2013-01-01

    In Amy Tan’s famous novel: The Joy Luck Club, ethnocentrism held by different groups including the mainstream so⁃ciety and minorities is to blame for cultural conflicts. In this article, it gives the theoretical framework by discussing the definition, function and consequences of ethnocentrism. The second chapter probes into Amy Tan’story and gives examples of ethnocen⁃trism held by family members within the minority group and by people around them. It concludes that the ethnocentrism is not limited to history or to some specific country or races. High level of ethnocentrism is dysfunctional, leading to misunderstanding and conflicts with out-group members. It is indicated that cultural relativism is the reasonable method people should adopt when they are involved in intercultural communication.

  5. Enhanced ID-Based Authentication Scheme Using OTP in Smart Grid AMI Environment

    Directory of Open Access Journals (Sweden)

    Sang-Soo Yeo

    2014-01-01

    Full Text Available This paper presents the vulnerabilities analyses of KL scheme which is an ID-based authentication scheme for AMI network attached SCADA in smart grid and proposes a security-enhanced authentication scheme which satisfies forward secrecy as well as security requirements introduced in KL scheme and also other existing schemes. The proposed scheme uses MDMS which is the supervising system located in an electrical company as a time-synchronizing server in order to synchronize smart devices at home and conducts authentication between smart meter and smart devices using a new secret value generated by an OTP generator every session. The proposed scheme has forward secrecy, so it increases overall security, but its communication and computation overhead reduce its performance slightly, comparing the existing schemes. Nonetheless, hardware specification and communication bandwidth of smart devices will have better conditions continuously, so the proposed scheme would be a good choice for secure AMI environment.

  6. Platform Deformation Refined Pointing and Phase Correction for the AMiBA Hexapod Telescope

    CERN Document Server

    Koch, Patrick M; Chang, Yu-Yen; Huang, Yau-De; Raffin, Philippe; Chen, Ke-Yung; Chereau, Guillaume; Chen, Ming-Tang; Ho, Paul T P; Huang, Chih-Wie; Ibanez-Romano, Fabiola; Jiang, Homin; Liao, Yu-Wei; Lin, Kai-Yang; Liu, Guo-Chin; Molnar, Sandor M; Nishioka, Hiroaki; Umetsu, Keiichi; Wang, Fu-Cheng; Wu, Jiun-Huei Proty; Altamirano, Pablo; Chang, Chia-Hao; Chang, Shu-Hao; Chang, Su-Wei; Han, Chi-Chiang; Kubo, Derek; Li, Chao-Te; Martin-Cocher, Pierre; Oshiro, Peter

    2009-01-01

    The Array for Microwave Background Anisotropy (AMiBA) is a radio interferometer for research in cosmology, currently operating 7 0.6m diameter antennas co-mounted on a 6m diameter platform driven by a hexapod mount. AMiBA is currently the largest hexapod telescope. We briefly summarize the hexapod operation with the current pointing error model. We then focus on the upcoming 13-element expansion with its potential difficulties and solutions. Photogrammetry measurements of the platform reveal deformations at a level which can affect the optical pointing and the receiver radio phase. In order to prepare for the 13-element upgrade, two optical telescopes are installed on the platform to correlate optical pointing tests. Being mounted on different locations, the residuals of the two sets of pointing errors show a characteristic phase and amplitude difference as a function of the platform deformation pattern. These results depend on the telescope's azimuth, elevation and polarization position. An analytical model ...

  7. Using AMIE data to study cloud processes within the Madden-Julian Oscillation

    Energy Technology Data Exchange (ETDEWEB)

    Houze, Robert A. [Univ. of Washington, Seattle, WA (United States). Dept. of Atmospheric Sciences

    2015-12-17

    This study uses AMIE data to show how the small clouds in the Madden-Julian Oscillation first organize into lines and other patterns, how they develop the first rainshowers, how those showers deposit cool air over the ocean surface, how this cool air spreads and triggers deeper convection, how the deep convection develops into mesoscale systems, how the mesoscale systems modify the heating profile through the depth of the troposphere, and how the development of the clouds responds to and interacts with large-scale waves circumnavigating the globe at upper levels, and how equatorial trapped waves at lower levels modulates the development of the cloud population. The techniques used to analyze the radar and sounding data collected in AMIE to achieve the above results are innovative, and to obtain more general results we have used regional modeling with a variety of cloud microphysical schemes in combination with the data analyses.

  8. Towards Efficient Energy Management: Defining HEMS, AMI and Smart Grid Objectives

    DEFF Research Database (Denmark)

    Rossello Busquet, Ana; Kardaras, Georgios; Soler, José

    2011-01-01

    electricity in the grid will also help to reduce the increase of energy consumption in the future. In order to reduce energy consumption in home environments, researches have been designing Home Energy Management Systems (HEMS). In addition, Advanced Metering Infrastructure (AMI) and smart grids are also...... being developed to distribute and produce electricity efficiently. This paper presents the high level goals and requirements of HEMS. Additionally, it gives an overview of Advanced Metering Infrastructure benefits and smart grids objectives....

  9. Towards Efficient Energy Management: Defining HEMS, AMI and Smart Grid Objectives

    DEFF Research Database (Denmark)

    Rossello Busquet, Ana; Kardaras, Georgios; Soler, José

    2011-01-01

    electricity in the grid will also help to reduce the increase of energy consumption in the future. In order to reduce energy consumption in home environments, researches have been designing Home Energy Management Systems (HEMS). In addition, Advanced Metering Infrastructure (AMI) and smart grids are also...... being developed to distribute and produce electricity efficiently. This paper presents the high level goals and requirements of HEMS. Additionally, it gives an overview of Advanced Metering Infrastructure benefits and smart grids objectives....

  10. Limnological Conditions in Lake William C. Bowen and Municipal Reservoir #1, Spartanburg County, South Carolina, August to September 2005, May 2006, and October 2006

    Science.gov (United States)

    Journey, Celeste A.; Abrahamsen, Thomas A.

    2008-01-01

    The U.S. Geological Survey, in cooperation with the Spartanburg Water System, conducted three spatial surveys of the limnological conditions in Lake William C. Bowen (Lake Bowen) and Municipal Reservoir #1 (Reservoir #1), Spartanburg County, South Carolina, during August to September 2005, May 2006, and October 2006. The surveys were conducted to identify spatial distribution and concentrations of geosmin and 2-methylisoborneol, common trophic state indicators (nutrients, transparency, and chlorophyll a), algal community structure, and stratification of the water column at the time of sampling. Screening tools such as the Carlson trophic state index, total nitrogen to total phosphorus ratios, and relative thermal resistance to mixing were used to help compare data among sites and among seasons. Water-column samples were collected at two depths at each selected site: a near-surface sample collected above a 1-meter depth and a lake-bottom sample collected at a depth of 2.5 to 7 meters, depending on the depth at the site. The degree of stratification of the water column was demonstrated by temperature-depth profiles and computed relative thermal resistance to mixing. Seasonal occurrence of thermal stratification (August to September 2005; May 2006) and de-stratification (October 2006) was evident in the depth profiles of water temperature in Lake Bowen. The most stable water-column (highest relative thermal resistance to mixing) conditions occurred in Lake Bowen during the August to September 2005 survey. The least stable water-column (destratified) conditions occurred in Lake Bowen during the October 2006 survey and Reservoir #1 during all three surveys. Changes with depth in dissolved oxygen (decreased with depth to near anoxic conditions in the hypolimnion), pH (decreased with depth), and specific conductance (increased with depth) along with thermal stratification indicated Lake Bowen was exhibiting characteristics common to both mesotrophic and eutrophic

  11. PLATFORM DEFORMATION PHASE CORRECTION FOR THE AMiBA-13 COPLANAR INTERFEROMETER

    Energy Technology Data Exchange (ETDEWEB)

    Liao, Yu-Wei; Lin, Kai-Yang; Huang, Yau-De; Ho, Paul T. P.; Chen, Ming-Tang; Locutus Huang, Chih-Wei; Koch, Patrick M.; Nishioka, Hiroaki; Umetsu, Keiichi; Han, Chih-Chiang; Li, Chao-Te; Martin-Cocher, Pierre; Oshiro, Peter [Institute of Astronomy and Astrophysics, Academia Sinica, P.O. Box 23-141, Taipei 10617, Taiwan (China); Proty Wu, Jiun-Huei; Cheng, Tai-An; Fu, Szu-Yuan; Wang, Fu-Cheng [Department of Physics, Institute of Astrophysics, and Center for Theoretical Sciences, National Taiwan University, Taipei 10617, Taiwan (China); Liu, Guo-Chin [Department of Physics, Tamkang University, 251-37 Tamsui, New Taipei City, Taiwan (China); Molnar, Sandor M. [Leung Center for Cosmology and Particle Astrophysics, National Taiwan University, Taipei 10617, Taiwan (China); Chang, Yu-Yen, E-mail: ywliao@asiaa.sinica.edu.tw, E-mail: jhpw@phys.ntu.edu.tw [Max-Planck-Institut fuer Astronomie, Koenigstuhl 17, D-69117 Heidelberg (Germany)

    2013-05-20

    We present a new way to solve the platform deformation problem of coplanar interferometers. The platform of a coplanar interferometer can be deformed due to driving forces and gravity. A deformed platform will induce extra components into the geometric delay of each baseline and change the phases of observed visibilities. The reconstructed images will also be diluted due to the errors of the phases. The platform deformations of The Yuan-Tseh Lee Array for Microwave Background Anisotropy (AMiBA) were modeled based on photogrammetry data with about 20 mount pointing positions. We then used the differential optical pointing error between two optical telescopes to fit the model parameters in the entire horizontal coordinate space. With the platform deformation model, we can predict the errors of the geometric phase delays due to platform deformation with a given azimuth and elevation of the targets and calibrators. After correcting the phases of the radio point sources in the AMiBA interferometric data, we recover 50%-70% flux loss due to phase errors. This allows us to restore more than 90% of a source flux. The method outlined in this work is not only applicable to the correction of deformation for other coplanar telescopes but also to single-dish telescopes with deformation problems. This work also forms the basis of the upcoming science results of AMiBA-13.

  12. AToMS: A Ubiquitous Teleconsultation System for Supporting AMI Patients with Prehospital Thrombolysis

    Directory of Open Access Journals (Sweden)

    Bruno S. P. M. Correa

    2011-01-01

    Full Text Available The latest population-based studies in the medical literature worldwide indicate that acute myocardial infarction (AMI patients still experience prolonged delay to be rescued, which often results in morbidity and mortality. This paper reports from a technological standpoint a teleconsultation and monitoring system named AToMS. This system addresses the problem of prehospital delivery of thrombolysis to AMI patients by enabling the remote interaction of the paramedics and a cardiologist available at a Coronary Care Unit (CCU. Such interaction allows the diagnosis of the patient eligibility to the immediate application of thrombolysis, which is meant to reduce the delay between the onset of symptoms and the eventual application of proper treatment. Such delay reduction is meant to increase the AMI patient's chances of survival and decrease the risks of postinfarction sequels. The teleconsultation is held with the support of wireless and mobile technologies, which also allows the cardiologist to monitor the patient while he/she is being taken to the nearest CCU. All exchanged messages among paramedics and cardiologists are recorded to render an auditable system. AToMS has been deployed in a first stage in the city of Rio de Janeiro, where the medical team involved in the project has conducted commissioned tests.

  13. Field evaluation of polymer capacitive humidity sensors for Bowen ratio energy balance flux measurements.

    Science.gov (United States)

    Savage, Michael J

    2010-01-01

    The possibility of reliable, reasonably accurate and relatively inexpensive estimates of sensible heat and latent energy fluxes was investigated using a commercial combination thin-film polymer capacitive relative humidity and adjacent temperature sensor instrument. Long-term and unattended water vapour pressure profile difference measurements using low-power combination instruments were compared with those from a cooled dewpoint mirror hygrometer, the latter often used with Bowen ratio energy balance (BREB) systems. An error analysis, based on instrument relative humidity and temperature errors, was applied for various capacitive humidity instrument models. The main disadvantage of a combination capacitive humidity instrument is that two measurements, relative humidity and temperature, are required for estimation of water vapour pressure as opposed to one for a dewpoint hygrometer. In a laboratory experiment using an automated procedure, water vapour pressure differences generated using a reference dewpoint generator were measured using a commercial model (Dew-10) dewpoint hygrometer and a combination capacitive humidity instrument. The laboratory measurement comparisons showed that, potentially, an inexpensive model combination capacitive humidity instrument (CS500 or HMP50), or for improved results a slightly more expensive model (HMP35C or HMP45C), could substitute for the more expensive dewpoint hygrometer. In a field study, in a mesic grassland, the water vapour pressure measurement noise for the combination capacitive humidity instruments was greater than that for the dewpoint hygrometer. The average water vapour pressure profile difference measured using a HMP45C was highly correlated with that from a dewpoint hygrometer with a slope less than unity. Water vapour pressure measurements using the capacitive humidity instruments were not as accurate, compared to those obtained using a dewpoint hygrometer, but the resolution magnitudes for the profile

  14. Field Evaluation of Polymer Capacitive Humidity Sensors for Bowen Ratio Energy Balance Flux Measurements

    Directory of Open Access Journals (Sweden)

    Michael J. Savage

    2010-08-01

    Full Text Available The possibility of reliable, reasonably accurate and relatively inexpensive estimates of sensible heat and latent energy fluxes was investigated using a commercial combination thin-film polymer capacitive relative humidity and adjacent temperature sensor instrument. Long-term and unattended water vapour pressure profile difference measurements using low-power combination instruments were compared with those from a cooled dewpoint mirror hygrometer, the latter often used with Bowen ratio energy balance (BREB systems. An error analysis, based on instrument relative humidity and temperature errors, was applied for various capacitive humidity instrument models. The main disadvantage of a combination capacitive humidity instrument is that two measurements, relative humidity and temperature, are required for estimation of water vapour pressure as opposed to one for a dewpoint hygrometer. In a laboratory experiment using an automated procedure, water vapour pressure differences generated using a reference dewpoint generator were measured using a commercial model (Dew-10 dewpoint hygrometer and a combination capacitive humidity instrument. The laboratory measurement comparisons showed that, potentially, an inexpensive model combination capacitive humidity instrument (CS500 or HMP50, or for improved results a slightly more expensive model (HMP35C or HMP45C, could substitute for the more expensive dewpoint hygrometer. In a field study, in a mesic grassland, the water vapour pressure measurement noise for the combination capacitive humidity instruments was greater than that for the dewpoint hygrometer. The average water vapour pressure profile difference measured using a HMP45C was highly correlated with that from a dewpoint hygrometer with a slope less than unity. Water vapour pressure measurements using the capacitive humidity instruments were not as accurate, compared to those obtained using a dewpoint hygrometer, but the resolution magnitudes for the

  15. Comparison and characterization of α-amylase inducers in Aspergillus nidulans based on nuclear localization of AmyR

    OpenAIRE

    Murakoshi, Yuriko; Makita, Tomohiro; Kato, Masashi; Kobayashi, Tetsuo

    2012-01-01

    AmyR, a fungal transcriptional activator responsible for induction of amylolytic genes in Aspergillus nidulans, localizes to the nucleus in response to the physiological inducer isomaltose. Maltose, kojibiose, and d-glucose were also found to trigger the nuclear localization of GFP-AmyR. Isomaltose- and kojibiose-triggered nuclear localization was not inhibited by the glucosidase inhibitor, castanospermine, while maltose-triggered localization was inhibited. Thus, maltose itself does not appe...

  16. Appending limited clinical data to an administrative database for assessing institutional quality outliers for AMI care: does it matter?

    Science.gov (United States)

    Weller, Wendy E; Kabra, Garima; Cozzens, Kimberly S; Hannan, Edward L

    2010-04-01

    The major objective of this study was to determine whether individual hospital performance would be assessed differently if clinical data were added to an administrative dataset. Patients in the 2004 New York State AMI Registry (AMI registry) who could be matched to patients in the New York State Hospital Discharge Database (SPARCS model) comprised the study sample (n=3153). Stepwise logistic regression models were developed (SPARCS model, SPARCS/AMI registry model). Risk-adjusted mortality rates (RAMR) for each hospital in the matched dataset were determined and compared for the SPARCS and the SPARCS/AMI registry model. The RAMR for each hospital was determined by dividing its observed mortality rate by its expected mortality rate and multiplying by the overall mortality rate for the state of New York. Hospitals were considered outliers if they had a RAMR significantly higher or lower than the overall statewide mortality rate. Hierarchical Models were also used to identify hospital outliers. The SPARCS logistic model identified two high hospital outliers; the SPARCS/AMI registry model identified one of those outliers and no others. When Hierarchical Models were used, the SPARCS model also identified two high outliers (one in common with the logistic model) and the SPARCS/AMI registry model identified one high outlier (the same as identified in the logistic model). It is worth exploring the impact of the addition of a small number of clinical data elements to administrative datasets on hospital outlier status. Copyright 2008 Elsevier Ireland Ltd. All rights reserved.

  17. Amidase Activity of AmiC Controls Cell Separation and Stem Peptide Release and Is Enhanced by NlpD in Neisseria gonorrhoeae.

    Science.gov (United States)

    Lenz, Jonathan D; Stohl, Elizabeth A; Robertson, Rosanna M; Hackett, Kathleen T; Fisher, Kathryn; Xiong, Kalia; Lee, Mijoon; Hesek, Dusan; Mobashery, Shahriar; Seifert, H Steven; Davies, Christopher; Dillard, Joseph P

    2016-05-13

    The human-restricted pathogen Neisseria gonorrhoeae encodes a single N-acetylmuramyl-l-alanine amidase involved in cell separation (AmiC), as compared with three largely redundant cell separation amidases found in Escherichia coli (AmiA, AmiB, and AmiC). Deletion of amiC from N. gonorrhoeae results in severely impaired cell separation and altered peptidoglycan (PG) fragment release, but little else is known about how AmiC functions in gonococci. Here, we demonstrated that gonococcal AmiC can act on macromolecular PG to liberate cross-linked and non-cross-linked peptides indicative of amidase activity, and we provided the first evidence that a cell separation amidase can utilize a small synthetic PG fragment as substrate (GlcNAc-MurNAc(pentapeptide)-GlcNAc-MurNAc(pentapeptide)). An investigation of two residues in the active site of AmiC revealed that Glu-229 is critical for both normal cell separation and the release of PG fragments by gonococci during growth. In contrast, Gln-316 has an autoinhibitory role, and its mutation to lysine resulted in an AmiC with increased enzymatic activity on macromolecular PG and on the synthetic PG derivative. Curiously, the same Q316K mutation that increased AmiC activity also resulted in cell separation and PG fragment release defects, indicating that activation state is not the only factor determining normal AmiC activity. In addition to displaying high basal activity on PG, gonococcal AmiC can utilize metal ions other than the zinc cofactor typically used by cell separation amidases, potentially protecting its ability to function in zinc-limiting environments. Thus gonococcal AmiC has distinct differences from related enzymes, and these studies revealed parameters for how AmiC functions in cell separation and PG fragment release.

  18. Família e o processo de individuação na perspectiva de Murray Bowen

    OpenAIRE

    Elizabeth Medeiros de Almeida Martins

    2005-01-01

    O estudo Família e o Processo de Individuação na Perspectiva de Murray Bowen tem como objetivo investigar a aplicabilidade do conceito de diferenciação do self em três casos clínicos, atendidos em clínica de terapia familiar, nos períodos de 1998 a 1999 e de 2002 a 2005. Pretendeu igualmente problematizar e ampliar uma análise crítica reflexiva, a partir do entendimento de que a família nuclear está inserida numa rede de relações multigeracionais na qual a sua funcionalidade é direcionada pel...

  19. In-situ analysis of solid bitumen in coal: Examples from the Bowen Basin and the Illinois Basin

    Science.gov (United States)

    Mastalerz, Maria; Glikson, M.

    2000-01-01

    Solid bitumen and associated vitrinite from selected coals from the Bowen Basin and the Illinois Basin were studied using electron microprobe and micro-FTIR techniques. The coal studied covers a range of vitrinite reflectance from 0.59% to 1.33%. Carbon content in the bitumen is generally lower than in vitrinite in coals with vitrinite reflectance below 0.67%. In coals with reflectance above 0.67%, carbon content of bitumen is higher than in vitrinite, reflecting higher aromaticity due to hydrocarbon generation. Sulfur and iron content are comparable between vitrinite and bitumen. Functional group distribution suggests the presence of two types of bitumen in the Illinois Basin coals. The more aliphatic variety occurring in veins and cleats is interpreted as pre-gas generation bitumen, and the more aromatic variety filling cells and voids in inertinite as post-gas generation bitumen. (C) 2000 Elsevier Science B.V. All rights reserved.Solid bitumen and associated vitrinite from selected coals from the Bowen Basin and the Illinois Basin were studied using electron microprobe and micro-FTIR techniques. The coal studied covers a range of vitrinite reflectance from 0.59% to 1.33%. Carbon content in the bitumen is generally lower than in vitrinite in coals with vitrinite reflectance below 0.67%. In coals with reflectance above 0.67%, carbon content of bitumen is higher than in vitrinite, reflecting higher aromaticity due to hydrocarbon generation. Sulfur and iron content are comparable between vitrinite and bitumen. Functional group distribution suggests the presence of two types of bitumen in the Illinois Basin coals. The more aliphatic variety occurring in veins and cleats is interpreted as pre-gas generation bitumen, and the more aromatic variety filling cells and voids in inertinite as post-gas generation bitumen.

  20. The peculiar mass-loss history of SN 2014C as revealed through AMI radio observations

    Science.gov (United States)

    Anderson, G. E.; Horesh, A.; Mooley, K. P.; Rushton, A. P.; Fender, R. P.; Staley, T. D.; Argo, M. K.; Beswick, R. J.; Hancock, P. J.; Pérez-Torres, M. A.; Perrott, Y. C.; Plotkin, R. M.; Pretorius, M. L.; Rumsey, C.; Titterington, D. J.

    2017-04-01

    We present a radio light curve of supernova (SN) 2014C taken with the Arcminute Microkelvin Imager (AMI) Large Array at 15.7 GHz. Optical observations presented by Milisavljevic et al. demonstrated that SN 2014C metamorphosed from a stripped-envelope Type Ib SN into a strongly interacting Type IIn SN within 1 yr. The AMI light curve clearly shows two distinct radio peaks, the second being a factor of 4 times more luminous than the first peak. This double bump morphology indicates two distinct phases of mass-loss from the progenitor star with the transition between density regimes occurring at 100-200 d. This reinforces the interpretation that SN 2014C exploded in a low-density region before encountering a dense hydrogen-rich shell of circumstellar material that was likely ejected by the progenitor prior to the explosion. The AMI flux measurements of the first light-curve bump are the only reported observations taken within ∼50 to ∼125 d post-explosion, before the blast-wave encountered the hydrogen shell. Simplistic synchrotron self-absorption and free-free absorption modelling suggest that some physical properties of SN 2014C are consistent with the properties of other Type Ibc and IIn SNe. However, our single frequency data does not allow us to distinguish between these two models, which implies that they are likely too simplistic to describe the complex environment surrounding this event. Lastly, we present the precise radio location of SN 2014C obtained with the electronic Multi-Element Remotely Linked Interferometer Network, which will be useful for future very long baseline interferometry observations of the SN.

  1. Acylation and deacylation mechanism of Helicobacter pylori AmiF formamidase: A computational DFT study

    Science.gov (United States)

    He, Rongxing; Yang, Qinlei; Li, Ming

    2014-04-01

    The acylation and deacylation mechanisms of Helicobacter pylori AmiF formamidase were investigated using DFT method. In the constructed active site, residues Glu60, Glu141 and His167 were taken into account besides Lys133 and Cys166. Calculations provided insight on the details of mechanism and explained crucial roles played by Glu60, Glu141 and His167. For acetylation, we proposed a new stepwise mechanism in which the thiol group first attacks the carbon atom of formamide and produces tetrahedral intermediate. In deacylation, Glu60 activates a water molecule to perform nucleophilic attack and then forms an intermediate, which is different from the usually suggested mechanism.

  2. Towards Efficient Energy Management: Defining HEMS, AMI and Smart Grid Objectives

    DEFF Research Database (Denmark)

    Rossello Busquet, Ana; Kardaras, Georgios; Soler, José;

    2011-01-01

    Energy consumption has increased considerably in the recent years. The way to reduce and make energy consumption more efficient has become of great interest for researchers. One of the research areas is the reduction of energy consumption in users’ residences. Efficiently managing and distributing...... electricity in the grid will also help to reduce the increase of energy consumption in the future. In order to reduce energy consumption in home environments, researches have been designing Home Energy Management Systems (HEMS). In addition, Advanced Metering Infrastructure (AMI) and smart grids are also...

  3. Degradation of Raw Corn Starch by an α-Amylase (AmyP) from Marine Environment%海洋环境来源的淀粉酶AmyP对生玉米淀粉的降解特性

    Institute of Scientific and Technical Information of China (English)

    彭惠; 雷寅; 刘源涛; 汪颖

    2012-01-01

    来自海洋宏基因组文库的α-淀粉酶(AmyP)属于最新建立的糖苷水解酶亚家族GH13_37.AmyP是一个生淀粉降解酶,能有效降解玉米生淀粉.在最适反应条件pH7.5和40℃下,生玉米淀粉的比活达到(39.6±1.4) U/mg.酶解反应动力学显示AmyP可以非常快速的降解生玉米淀粉.对1%的生玉米淀粉降解仅需要30min;4%和8%的生玉米淀粉只需3h.DTT可以显著提高AmyP对生玉米淀粉的降解活性,1% DTT促使活性增加1倍.根据电镜观察和产物分析,认为AmyP是以内腐蚀的模式降解生玉米淀粉颗粒,释放出葡萄糖、麦芽糖和麦芽三糖作为终产物.%The α-amylase ( AmyP) from a marine metagenomic library belongs to the recently classified glycoside hydrolase subfamily GH13_37. AmyP is raw starch degrading enzyme, exhibiting a remarkable ability to digest raw corn starch. The specific activity of raw corn starch was reached (39. 6 ± 1.4) U/mg under the optimum pH 7. 5 and temperature 40 ℃. The hydrolysis curve showed that AmyP could hydrolyze raw corn starch at a very high speed. The final hydrolysis degrees were obtained in 30min for 1% raw corn starch and 3h for 4% and 8% concentration. The enzyme's activity was greatly increased in the presence of DTT. 1% DTT led to a twofold-enhanced activity. The results of scanning electron microscopy and thin-layer chromatography show that AmyP attacks sites on raw corn starch granules with a mode of endo-corrosion, and releases glucose, maltose and maltotriose as end products.

  4. Ontological Representation of Light Wave Camera Data to Support Vision-Based AmI

    Directory of Open Access Journals (Sweden)

    José Manuel Molina

    2012-09-01

    Full Text Available Recent advances in technologies for capturing video data have opened a vast amount of new application areas in visual sensor networks. Among them, the incorporation of light wave cameras on Ambient Intelligence (AmI environments provides more accurate tracking capabilities for activity recognition. Although the performance of tracking algorithms has quickly improved, symbolic models used to represent the resulting knowledge have not yet been adapted to smart environments. This lack of representation does not allow to take advantage of the semantic quality of the information provided by new sensors. This paper advocates for the introduction of a part-based representational level in cognitive-based systems in order to accurately represent the novel sensors’ knowledge. The paper also reviews the theoretical and practical issues in part-whole relationships proposing a specific taxonomy for computer vision approaches. General part-based patterns for human body and transitive part-based representation and inference are incorporated to an ontology-based previous framework to enhance scene interpretation in the area of video-based AmI. The advantages and new features of the model are demonstrated in a Social Signal Processing (SSP application for the elaboration of live market researches.

  5. Constraining Intra-cluster Gas Models with AMiBA13

    CERN Document Server

    Molnar, Sandor M; Birkinshaw, Mark; Bryan, Greg; Haiman, Zoltan; Hearn, Nathan; Ho, Paul T P; Huang, Chih-Wei L; Koch, Patrick M; Liao, Yu-Wei V; Linh, Kai-Yang; Liuh, Guo-Chin; Nishioka, Hiroaki; Wang, Fu-Cheng; Wu, Jiun-Huei P; Astronomy, Institute of; Astrophysics,; Sinica, Academia; 23-141, P O Box; 106, Taipei; Taiwan,; ROC,; Laboratory, H H Wills Physics; Bristol, University of; Ave, Tyndall; 1TL, Bristol BS8; UK,; Astronomy, Department of; University, Columbia; Street, 550 West 120th; York, New; 10027, NY; Flashes, ASC/Alliances Center for Astrophysical Thermonuclear; Chicago, University of; 60637, Chicago IL; Astrophysics, Harvard-Smithsonian Center for; Street, 60 Garden; Cambridge,; 02138, MA; Physics, Department of; Astrophysics, Institute of; University, National Taiwan; 10617, Taipei; Taiwan,; ROC,; Physics, Department of; University, Tamkang; 251-37,; Tamsui,; County, Taipei; Taiwan,; ROC,

    2010-01-01

    Clusters of galaxies have been used extensively to determine cosmological parameters. A major difficulty in making best use of Sunyaev--Zel'dovich (SZ) and X-ray observations of clusters for cosmology is that using X-ray observations it is difficult to measure the temperature distribution and therefore determine the density distribution in individual clusters of galaxies out to the virial radius. Observations with the new generation of SZ instruments are a promising alternative approach. We use clusters of galaxies drawn from high-resolution adaptive mesh refinement (AMR) cosmological simulations to study how well we should be able to constrain the large-scale distribution of the intra-cluster gas (ICG) in individual massive relaxed clusters using AMiBA in its configuration with 13 1.2-m diameter dishes (AMiBA13) along with X-ray observations. We show that non-isothermal beta models provide a good description of the ICG in our simulated relaxed clusters. We use simulated X-ray observations to estimate the qua...

  6. AMI radio continuum observations of young stellar objects with known outflows

    CERN Document Server

    Ainsworth, Rachael E; Ray, Tom P; Buckle, Jane V; Davies, Matthew; Franzen, Thomas M O; Grainge, Keith J B; Hobson, Michael P; Hurley-Walker, Natasha; Lasenby, Anthony N; Olamaie, Malak; Perrott, Yvette C; Pooley, Guy G; Richer, John S; Rodriguez-Gonzalvez, Carmen; Schammel, Michel P; Scott, Paul F; Shimwell, Timothy; Saunders, Richard D E; Titterington, David; Waldram, Elizabeth

    2012-01-01

    We present 16 GHz (1.9 cm) deep radio continuum observations made with the Arcminute Microkelvin Imager (AMI) of a sample of low-mass young stars driving jets. We combine these new data with archival information from an extensive literature search to examine spectral energy distributions (SEDs) for each source and calculate both the radio and sub-mm spectral indices in two different scenarios: (1) fixing the dust temperature (Td) according to evolutionary class; (2) allowing Td to vary. We use the results of this analysis to place constraints on the physical mechanisms responsible for the radio emission. From AMI data alone, as well as from model fitting to the full SED in both scenarios, we find that 80 per cent of the objects in this sample have spectral indices consistent with free-free emission. We find an average spectral index in both Td scenarios consistent with free-free emission. We examine correlations of the radio luminosity with bolometric luminosity, envelope mass, and outflow force and find that...

  7. Failure Impact Analysis of Key Management in AMI Using Cybernomic Situational Assessment (CSA)

    Energy Technology Data Exchange (ETDEWEB)

    Abercrombie, Robert K [ORNL; Sheldon, Frederick T [ORNL; Hauser, Katie R [ORNL; Lantz, Margaret W [ORNL; Mili, Ali [New Jersey Insitute of Technology

    2013-01-01

    In earlier work, we presented a computational framework for quantifying the security of a system in terms of the average loss a stakeholder stands to sustain as a result of threats to the system. We named this system, the Cyberspace Security Econometrics System (CSES). In this paper, we refine the framework and apply it to cryptographic key management within the Advanced Metering Infrastructure (AMI) as an example. The stakeholders, requirements, components, and threats are determined. We then populate the matrices with justified values by addressing the AMI at a higher level, rather than trying to consider every piece of hardware and software involved. We accomplish this task by leveraging the recently established NISTR 7628 guideline for smart grid security. This allowed us to choose the stakeholders, requirements, components, and threats realistically. We reviewed the literature and selected an industry technical working group to select three representative threats from a collection of 29 threats. From this subset, we populate the stakes, dependency, and impact matrices, and the threat vector with realistic numbers. Each Stakeholder s Mean Failure Cost is then computed.

  8. Advances in Autonomous Mini Robots : Proceedings of the 6-th AMiRE Symposium

    CERN Document Server

    Joaquin, Sitte; Felix, Werner

    2012-01-01

    Autonomous robots must carry out useful tasks all by themselves relying entirely on their own perceptions of their environment. The cognitive abilities required for autonomous action are largely independent of robot size, which makes mini robots attractive as artefacts for research, education and entertainment. Autonomous mini robots must be small enough for experimentation on a desktop or a small laboratory.  They must be easy to carry and safe for interaction with humans. They must not be expensive. Mini robot designers have to work at the leading edge of technology so that their creations can carry out purposeful autonomic action under these constraints. Since 2001 researchers have met every two years for an international symposium to report on the advances achieved in Autonomous Mini  Robots for Research and Edutainment (AMiRE). The AMiRE Symposium is a single track conference that offers ample opportunities for discussion and exchange of ideas. This volume contains the contributed papers of the 2011 AM...

  9. Diasporic Authenticity Assertions: Analysis of Amy Tan’s The Bonesetter’s Daughter

    Directory of Open Access Journals (Sweden)

    Naeimeh Tabatabaei Lotfi

    2015-07-01

    Full Text Available This essay is an attempt to examine the active interaction of history and memory, in formulation of a diasporic authentic picture of past, in Amy Tan’s The Bonesetter’s Daughter (2001. Amongst discursive disciplines, memory and history perform vitally, in picturing past; both attempt to reproduce events, by emblematic narrative acts. However, their erratic quality endorses the existence of counter- stories that endangers displaying a homogeneous past. Among miscellaneous categories of memories, autobiographical memory asserts to obtain an authentic presentation, but as any other forms of accounts, it exhibits an imprecise fictional image. This psychological alleviation ensures the future mental integrity of trauma victims. In memory narratives, the contingent temperament of power network and continual formulation of resisting frameworks might be explored. Tan’s diasporic assertion of authenticity, as a migrant writer, amalgamated with employment of fantasy is to obtain a shared diasporic identity, among her characters, although personal accounts of characters undergo an extensive amount of contingency. The newly forged identity is collective in nature and defies the geographical and temporal borders and grants a humane picture rather than a diasporic one; an identity that is established to venerate the cardinal role of personal memory, in endowing legitimate truth. Keywords: Amy Tan- Authenticity Assertion- Memory- History- Diasporic Narrative

  10. The late Proterozoic Amis River Formation of Namibia—a turbidite system developed by vertical accretion

    Science.gov (United States)

    Swart, Roger

    1990-04-01

    Vertical facies changes form the fundamental basis of interpretation of many submarine turbidite systems. Some systems, however, do not show major vertical cyclicity over thicknesses of hundreds of metres, but rather display significant lateral changes. The late Proterozoic Amis River Formation of Namibia, which contains the facies typical of submarine turbidite systems, shows little vertical variation but has major lateral changes. In the west of the exposed area the sequence consists predominantly of bundles of facies C 2 and D 1 (facies scheme of Mutti and Ricci Lucchi, 1975) with interbedded packages of facies B 1 beds, which become more common upwards. Only minor vertical cyclicity is observed, beds are laterally continuous for many kilometres and the sandstone: shale ratio is high. In the east largely thin-bedded facies D 2 beds occur with a much lower sandstone: shale ratio than in the west. This system is interpreted here as developing largely by vertical accretion rather than progradation.

  11. Automating Routine Tasks in AmI Systems by Using Models at Runtime

    Science.gov (United States)

    Serral, Estefanía; Valderas, Pedro; Pelechano, Vicente

    One of the most important challenges to be confronted in Ambient Intelligent (AmI) systems is to automate routine tasks on behalf of users. In this work, we confront this challenge presenting a novel approach based on models at runtime. This approach proposes a context-adaptive task model that allows routine tasks to be specified in an understandable way for users, facilitating their participation in the specification. These tasks are described according to context, which is specified in an ontology-based context model. Both the context model and the task model are also used at runtime. The approach provides a software infrastructure capable of automating the routine tasks as they were specified in these models by interpreting them at runtime.

  12. Science objectives and first results from the SMART-1/AMIE multicolour micro-camera

    Science.gov (United States)

    Josset, J.-L.; Beauvivre, S.; Cerroni, P.; de Sanctis, M. C.; Pinet, P.; Chevrel, S.; Langevin, Y.; Barucci, M. A.; Plancke, P.; Koschny, D.; Almeida, M.; Sodnik, Z.; Mancuso, S.; Hofmann, B. A.; Muinonen, K.; Shevchenko, V.; Shkuratov, Yu.; Ehrenfreund, P.; Foing, B. H.

    The Advanced Moon micro-Imager Experiment (AMIE), on-board SMART-1, the first European mission to the Moon, is an imaging system with scientific, technical and public outreach objectives. The science objectives are to image the lunar South Pole, permanent shadow areas (ice deposit), eternal light (crater rims), ancient lunar non-mare volcanism, local spectrophotometry and physical state of the lunar surface, and to map high latitudes regions (south) mainly at far side (South Pole Aitken basin). The technical objectives are to perform a Laserlink experiment (detection of laser beam emitted by ESA/Tenerife ground station), flight demonstration of new technologies and on-board autonomy navigation. The public outreach and educational objectives are to promote planetary exploration and space. We present here the first results obtained during the cruise phase.

  13. Long-term follow-up of metil aminolevulinate (MAL)-PDT in difficult-to-treat cutaneous Bowen's disease.

    Science.gov (United States)

    Cavicchini, Stefano; Serini, Stefano Maria; Fiorani, Roberta; Girgenti, Valentina; Ghislanzoni, Massimo; Sala, Francesco

    2011-08-01

    Bowen's disease (BD) is a form of intraepidermal squamous cell carcinoma, which is clinically characterized by gradually enlarging, well-demarcated erythematous plaques with irregular borders and surface crusting or scaling, affecting primarily the elderly. BD often presents with lesions difficult to treat with standard therapy as surgery, cryosurgery, or 5-fluorouracil (5-FU) for the risk of significantly poor cosmetic outcome, failure rate, and adverse events, related mainly to the age of the patients. Topical PDT with methyl aminolevulinate (MAL) represents a valid and approved therapy for BD lesions in many cases, especially for lesions located at poor healing sites or for large patches of disease, due to its high efficacy coupled with good tolerability and tissue-sparing attitude. In this study, we sought to investigate the efficacy, safety, and cosmetic outcome of MAL-PDT in a series of patients with BD lesions which were challenging to treat for clinical, surgical, and patient-related reasons, such as size of the lesion, difficult surgical approach for anatomical sites, or age of patients and request of the best cosmetic result. We also performed a long-term follow-up to assess recurrence rates and eventual late-onset adverse events.

  14. Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape.

    Directory of Open Access Journals (Sweden)

    Catherine Chaput

    2006-09-01

    Full Text Available The human gastric pathogen Helicobacter pylori is responsible for peptic ulcers and neoplasia. Both in vitro and in the human stomach it can be found in two forms, the bacillary and coccoid forms. The molecular mechanisms of the morphological transition between these two forms and the role of coccoids remain largely unknown. The peptidoglycan (PG layer is a major determinant of bacterial cell shape, and therefore we studied H. pylori PG structure during the morphological transition. The transition correlated with an accumulation of the N-acetyl-D-glucosaminyl-beta(1,4-N-acetylmuramyl-L-Ala-D-Glu (GM-dipeptide motif. We investigated the molecular mechanisms responsible for the GM-dipeptide motif accumulation, and studied the role of various putative PG hydrolases in this process. Interestingly, a mutant strain with a mutation in the amiA gene, encoding a putative PG hydrolase, was impaired in accumulating the GM-dipeptide motif and transforming into coccoids. We investigated the role of the morphological transition and the PG modification in the biology of H. pylori. PG modification and transformation of H. pylori was accompanied by an escape from detection by human Nod1 and the absence of NF-kappaB activation in epithelial cells. Accordingly, coccoids were unable to induce IL-8 secretion by AGS gastric epithelial cells. amiA is, to our knowledge, the first genetic determinant discovered to be required for this morphological transition into the coccoid forms, and therefore contributes to modulation of the host response and participates in the chronicity of H. pylori infection.

  15. MR tomography of focal liver lesions using the superparamagnetic contrast agent AMI-25 at 1.5 tesla; MR-Tomographie fokaler Leberlaesionen mit dem superparamagnetischen Kontrastmittel AMI-25 bei 1,5 Tesla

    Energy Technology Data Exchange (ETDEWEB)

    Duda, S.H. [Tuebingen Univ. (Germany). Abt. fuer Radiologische Diagnostik; Laniado, M. [Tuebingen Univ. (Germany). Abt. fuer Radiologische Diagnostik; Kopp, A.F. [Tuebingen Univ. (Germany). Abt. fuer Radiologische Diagnostik; Groenewaeller, E. [Tuebingen Univ. (Germany). Abt. fuer Radiologische Diagnostik; Aicher, K.P. [Tuebingen Univ. (Germany). Abt. fuer Radiologische Diagnostik; Pavone, P. [Univ. `La Sapienza`, Rome (Germany). Abt. fuer Radiologische Diagnostik; Jehle, E. [Tuebingen Univ. (Germany). Abt. fuer Allgemeinchirurgie; Claussen, C.D. [Tuebingen Univ. (Germany). Abt. fuer Radiologische Diagnostik

    1994-01-01

    Superparamagnetic iron oxide particles (AMI-25) were evaluated as a liver contrast agent in high-field MR imaging (1.5 T). 16 patients with up to 5 presumed focal liver lesions (liver metastases n=8, HCC n=5, Klatskin tumours n=2, FNH n=1) received 15 {mu}mol Fe/kg BW intravenously and were examined via standard T{sub 1}- and T{sub 2}-weighted spin-echo sequences. Quantitative image analysis showed a post-contrast increase of the contrast-to-noise ratio (C/N) from 1.6 to 7.4 on SE 2,500/15 images (p<.05). However, C/N was in the same range on plain SE 2,500/90 scans. Blind evaluation by two independent readers revealed that AMI-25-enhanced images did not provide a significantly increased number of lesions. Two patients reported minor, self-limited side-effects (flush, back pain). We conclude that in contrast to reports at mid-field MR imagers, the use of AMI-25 at 1.5 T does not significantly improve the detection of focal liver lesions on conventional SE images. (orig.) [Deutsch] Die Vertraeglichkeit und diagnostische Wirksamkeit eines superparamagnetischen MR-Leberkontrastmittels wurde untersucht. Die Eisenoxidpartikel (AMI-25, Guerbet, Frankreich) wurden 16 Patienten (Lebermetastasen n=8, HCC n=5, Klatskin-Tumor n=2, FNH n=1) mit bis zu 5 vermuteten fokalen Leberlaesionen in einer Dosis von 15 {mu}mol Fe/kg i.v. verabreicht. Vor und 60 Minuten nach Infusionsbeginn erfolgten T{sub 1}- und T{sub 2}-gewichtete SE-Aufnahmen bei 1,5 T. Die quantitative Auswertung ergab einen Anstieg des KRV von 1,6{+-}6,3 auf 7,4{+-}4,9 nach Gabe von AMI-25 (p<0,05) (SE 2500/15). Das KRV nativer T{sub 2}-gewichteter Aufnahmen lag jedoch mit 6,3{+-}3,1 in derselben Groessenordnung (SE 2500/90). Die Blindanalyse der Prae- und Postkontrastbilder durch zwei Auswerter ergab keinen signifikanten Anstieg der Sensitivitaet nach AMI-25. Zwei der 16 Patienten berichteten jeweils eine voruebergehende Nebenwirkung (Flush, Rueckenschmerzen). Bei 1,5 T liess sich an unserem kleinen

  16. A broader role for AmyR in Aspergillus niger: regulation of the utilisation of d-glucose or d-galactose containing oligo- and polysaccharides

    NARCIS (Netherlands)

    vanKuyk, P.A.; Benen, J.A.E.; Wosten, H.A.B.; Visser, de J.A.G.M.; Vries, de R.P.

    2012-01-01

    AmyR is commonly considered a regulator of starch degradation whose activity is induced by the presence of maltose, the disaccharide building block of starch. In this study, we demonstrate that the role of AmyR extends beyond starch degradation. Enzyme activity assays, genes expression analysis and

  17. The Brief Analysis of Faux Amis in Chinese-English Translation---Taking Two Sets of Words for Example

    Institute of Scientific and Technical Information of China (English)

    杜杨

    2014-01-01

    Taking “个人主义”& “individualism” and “封建”&“feudal” for example, this paper gives the brief analysis of faux amis in Chinese-English translation, and puts forward some measures to avoid them in translation.

  18. Biochemical and Structural Characterization of Amy1: An Alpha-Amylase from Cryptococcus flavus Expressed in Saccharomyces cerevisiae

    Science.gov (United States)

    Galdino, Alexsandro Sobreira; Silva, Roberto Nascimento; Lottermann, Muriele Taborda; Álvares, Alice Cunha Morales; de Moraes, Lídia Maria Pepe; Torres, Fernando Araripe Gonçalves; de Freitas, Sonia Maria; Ulhoa, Cirano José

    2011-01-01

    An extracellular alpha-amylase (Amy1) whose gene from Cryptococcus flavus was previously expressed in Saccharomyces cerevisiae was purified to homogeneity (67 kDa) by ion-exchange and molecular exclusion chromatography. The enzyme was activated by NH4+ and inhibited by Cu+2 and Hg+2. Significant biochemical and structural discrepancies between wild-type and recombinant α-amylase with respect to Km values, enzyme specificity, and secondary structure content were found. Far-UV CD spectra analysis at pH 7.0 revealed the high thermal stability of both proteins and the difference in folding pattern of Amy1 compared with wild-type amylase from C. flavus, which reflected in decrease (10-fold) of enzymatic activity of recombinant protein. Despite the differences, the highest activity of Amy1 towards soluble starch, amylopectin, and amylase, in contrast with the lowest activity of Amy1w, points to this protein as being of paramount biotechnological importance with many applications ranging from food industry to the production of biofuels. PMID:21490699

  19. Phosphorylation of DegU is essential for activation of amyE expression in Bacillus subtilis

    Indian Academy of Sciences (India)

    Monica Gupta; K Krishnamurthy Rao

    2014-12-01

    Alpha ()-amylase (amyE) is one of the major exo-enzymes secreted by Bacillus subtilis during the post-exponential phase. The DegS-DegU two-component system regulates expression of majority of post-exponentially expressed genes in B. subtilis. It has been demonstrated that varying levels of the phosphorylated form of DegU (DegU-P) control different cellular processes. Exo-protease production is observed when effective concentration of DegU-P rises in the cell, whereas swarming motility is favoured at very low amounts of DegU-P. In this study we show that like other exo-proteases, expression of amyE is positively regulated by increase in DegU-P levels in the cell. We also demonstrate that residues at the DNA-binding helix-turn-helix (HTH) motif of DegU are necessary for the amyE expression. This observation is further reinforced by demonstrating the direct interaction of DegU on amyE promoter.

  20. What Belongs in a Montessori Primary Classroom? Results from a Survey of AMI and AMS Teacher Trainers

    Science.gov (United States)

    Lillard, Angeline S.

    2011-01-01

    There are two major types of Montessori teacher education in the United States: (1) AMI-USA (the American branch of the Association Montessori Internationale, founded by Dr. Montessori to carry on her work); and (2) AMS (American Montessori Society, founded by Nancy Rambusch to represent Montessori in America). This article presents the results…

  1. What Belongs in a Montessori Primary Classroom? Results from a Survey of AMI and AMS Teacher Trainers

    Science.gov (United States)

    Lillard, Angeline S.

    2011-01-01

    There are two major types of Montessori teacher education in the United States: (1) AMI-USA (the American branch of the Association Montessori Internationale, founded by Dr. Montessori to carry on her work); and (2) AMS (American Montessori Society, founded by Nancy Rambusch to represent Montessori in America). This article presents the results…

  2. Contribution of AmyA, an extracellular alpha-glucan degrading enzyme, to group A streptococcal host-pathogen interaction.

    Science.gov (United States)

    Shelburne, Samuel A; Keith, David B; Davenport, Michael T; Beres, Stephen B; Carroll, Ronan K; Musser, James M

    2009-10-01

    alpha-Glucans such as starch and glycogen are abundant in the human oropharynx, the main site of group A Streptococcus (GAS) infection. However, the role in pathogenesis of GAS extracellular alpha-glucan binding and degrading enzymes is unknown. The serotype M1 GAS genome encodes two extracellular proteins putatively involved in alpha-glucan binding and degradation; pulA encodes a cell wall anchored pullulanase and amyA encodes a freely secreted putative cyclomaltodextrin alpha-glucanotransferase. Genetic inactivation of amyA, but not pulA, abolished GAS alpha-glucan degradation. The DeltaamyA strain had a slower rate of translocation across human pharyngeal epithelial cells. Consistent with this finding, the DeltaamyA strain was less virulent following mouse mucosal challenge. Recombinant AmyA degraded alpha-glucans into beta-cyclomaltodextrins that reduced pharyngeal cell transepithelial resistance, providing a physiologic explanation for the observed transepithelial migration phenotype. Higher amyA transcript levels were present in serotype M1 GAS strains causing invasive infection compared with strains causing pharyngitis. GAS proliferation in a defined alpha-glucan-containing medium was dependent on the presence of human salivary alpha-amylase. These data delineate the molecular mechanisms by which alpha-glucan degradation contributes to GAS host-pathogen interaction, including how GAS uses human salivary alpha-amylase for its own metabolic benefit.

  3. The Dynamics of Complex Formation between Amy lose Brushes on Gold and Fatty Acids by QCM-D

    NARCIS (Netherlands)

    Cao, Zheng; Tsoufis, Theodoros; Svaldo-Lanero, Tiziana; Duwez, Anne-Sophie; Rudolf, Petra; Loos, Katja

    2013-01-01

    Amy lose brushes were synthesized by enzymatic polymerization with glucose-l-phosphate as monomer and rabbit muscle phosphorylase b as catalyst on gold-covered surfaces of a quartz crystal microbalance. Fourier transform infrared (FT-IR) spectra confirmed the presence of the characteristic absorptio

  4. Biochemical and Structural Characterization of Amy1: An Alpha-Amylase from Cryptococcus flavus Expressed in Saccharomyces cerevisiae

    Directory of Open Access Journals (Sweden)

    Alexsandro Sobreira Galdino

    2011-01-01

    Full Text Available An extracellular alpha-amylase (Amy1 whose gene from Cryptococcus flavus was previously expressed in Saccharomyces cerevisiae was purified to homogeneity (67 kDa by ion-exchange and molecular exclusion chromatography. The enzyme was activated by NH4+ and inhibited by Cu+2 and Hg+2. Significant biochemical and structural discrepancies between wild-type and recombinant α-amylase with respect to Km values, enzyme specificity, and secondary structure content were found. Far-UV CD spectra analysis at pH 7.0 revealed the high thermal stability of both proteins and the difference in folding pattern of Amy1 compared with wild-type amylase from C. flavus, which reflected in decrease (10-fold of enzymatic activity of recombinant protein. Despite the differences, the highest activity of Amy1 towards soluble starch, amylopectin, and amylase, in contrast with the lowest activity of Amy1w, points to this protein as being of paramount biotechnological importance with many applications ranging from food industry to the production of biofuels.

  5. Investigations of Possible Low-Level Temperature and Moisture Anomalies During the AMIE Field Campaign on Manus Island

    Energy Technology Data Exchange (ETDEWEB)

    Long, CN; Holdridge, DJ

    2012-11-19

    This document discusses results stemming from the investigation of near-surface temperature and moisture “oddities” that were brought to light as part of the Atmospheric Radiation Measurement (ARM) Madden-Julian Oscillation (MJO) Investigation Experiment (AMIE), Dynamics of the Madden-Julian Oscillation (DYNAMO), and Cooperative Indian Ocean experiment on intraseasonal variability in the Year 2011 (CINDY2011) campaigns.

  6. α-淀粉酶基因amyP在家蚕生物反应器中的表达

    Institute of Scientific and Technical Information of China (English)

    杨灵; 徐慧琴; 张志芳; 李轶女

    2014-01-01

    从高温菌Geobacillus. sp. POT5基因组中扩增得到推定的α-淀粉酶基因amyP,将其插入杆状病毒转移载体pVL1393上,获得重组转移载体pVL-amyP,经与线性化的亲本病毒DNA共转染家蚕细胞Bm-5后,通过体内同源重组的方式获得重组杆状病毒,将重组病毒感染家蚕5龄幼虫,提取发病家蚕血淋巴液进行淀粉酶活力分析,结果表明amyP基因在家蚕生物反应器中得到了正确的表达。%The putatived α-amylased gene is amplified from the genome of thermostable strain Geobacillus. sp. POT5 and is inserted into the transfer vector pVL1393. Thus the recombinant transfer vector pVL-amyP is obtained and co-transfected with linerizated parental virus DNA into the Bm-5 cells. The recombinant baculovirus is obtained by homologous recombination. Recombinant virus infect 5 instar larvae of silkworm, hemolymph is extracted and performed with activity analysis ofα-amylase. The results indicat that the amyP gene is correctly expressed in the silkworm.

  7. Euro Heart Survey 2009 Snapshot: regional variations in presentation and management of patients with AMI in 47 countries

    Science.gov (United States)

    Puymirat, Etienne; Battler, Alex; Birkhead, John; Bueno, Hector; Clemmensen, Peter; Cottin, Yves; Fox, Keith AA; Gorenek, Bulent; Hamm, Christian; Huber, Kurt; Lettino, Maddalena; Lindahl, Bertil; Müller, Christian; Parkhomenko, Alexander; Price, Susanna; Quinn, Tom; Schiele, Francois; Simoons, Maarten; Tatu-Chitoiu, Gabriel; Tubaro, Marco; Vrints, Christiaan; Zahger, Doron; Zeymer, Uwe

    2013-01-01

    Aims: Detailed data on patients admitted for acute myocardial infarction (AMI) on a European-wide basis are lacking. The Euro Heart Survey 2009 Snapshot was designed to assess characteristics, management, and hospital outcomes of AMI patients throughout European Society of Cardiology (ESC) member countries in a contemporary ‘real-world’ setting, using a methodology designed to improve the representativeness of the survey. Methods: Member countries of the ESC were invited to participate in a 1-week survey of all patients admitted for documented AMI in December 2009. Data on baseline characteristics, type of AMI, management, and complications were recorded using a dedicated electronic form. In addition, we used data collected during the same time period in national registries in Sweden, England, and Wales. Data were centralized at the European Heart House. Results: Overall, 4236 patients (mean age 66±13 years; 31% women) were included in the study in 47 countries. Sixty per cent of patients had ST-segment elevation myocardial infarction, with 50% having primary percutaneous coronary intervention and 21% fibrinolysis. Aspirin and thienopyridines were used in >90%. Unfractionated and low-molecular-weight heparins were the most commonly used anticoagulants. Statins, beta-blockers, and angiotensin-converting enzyme inhibitors were used in >80% of the patients. In-hospital mortality was 6.2%. Regional differences were observed, both in terms of population characteristics, management, and outcomes. Conclusions: In-hospital mortality of patients admitted for AMI in Europe is low. Although regional variations exist in their presentation and management, differences are limited and have only moderate impact on early outcomes. PMID:24338295

  8. Cold-climate, fluvial to paralic coal-forming environments in the Permian Collinsville Coal Measures, Bowen Basin, Australia

    Energy Technology Data Exchange (ETDEWEB)

    Martini, I.P.; Johnson, D.P.

    1987-05-01

    The Middle Permian Collinsville Coal Measures of the northern Bowen Basin illustrate a range of cold to cold-temperate, coal-forming environments. Cold climate is indicated by Glossopteris flora in the Coal Measures and by restricted marine fauna dominated by brachiopods and bryozoa in correlative marine sequences of the Back Creek Group which contains also abundant lonestones (dropstones). Sedimentation was characterised by an overall transgression, interrupted by local fluvial and coastal progradation in a shallow, epicontinental sea during a relatively quiescent tectonic period. Six sedimentary environments are represented: fluvial, fluvio-paralic, barrier-strandplain, back-barrier, tidal flat and open marine. The basal coal formed from peat of swamps of abandoned areas of gravelly braided streams, and is massive, dull, and with high ash (20%), low sulphur (1%) contents. Overlying coals developed from peats formed in fluvio-paralic and paralic environments, and thicker seams are generally brighter, with low to moderate ash (8-17%) and moderate to high total sulphur (1-6%) contents. Seams associated with fluvial influence show splits and high ash yield, while seams associated with coastal deposits show high sulphur levels (up to 21%). In contrast to reported models of coal-forming environments, no clearly defined deltaic or interdistributary bay-fill sequences were identified in the area studied. Rather, vast freshwater wetlands backed low-gradient, progradational coasts locally having bars and barriers. The barriers were not prerequisites for substantial peat accumulation, although may have locally assisted peatland development by raising the profile of coastal equilibrium. 37 refs.

  9. Application of detailed temperature profile measurements for improving data quality check by Bowen Ratio/Energy Balance method

    Science.gov (United States)

    Pozníková, Gabriela; Fischer, Milan; Orság, Matěj; Trnka, Miroslav; Žalud, Zdeněk

    2015-04-01

    Water plays a key role in the functionality and sustainability of the ecosystems. In the light of the predicted climate change research should be focused on the water cycle and its individual components. Apart from the runoff, the major component of the water balance which drives the water from the ecosystems is represented by the evapotranspiration (ET). One of the standard methods for measuring ET is Bowen Ratio/Energy Balance method (BREB). It is based on the assumption that the water vapour and heat are transported by identical eddies with equal efficiency. In fact, this basic premise is based on a more complicated Monin-Obukhov similarity theory that explains the relationship between the profiles of wind, temperature and water vapour in the surface layer of the atmosphere. When BREB method is used we assume that the profiles of temperature and air humidity are ideally logarithmic or at least consistent. However, as this method is usually based on the measurements of temperature and humidity in only two heights, it is difficult to verify this assumption. We therefore conducted a field experiment using 4m high measurement-mast with 20 thermocouples connected to data-logger for detailed measurement of air temperature profile above different covers, e.g. grassland, spring barley, poplar plantation. The main goal of our effort was to capture so called "kink" in the profile of the temperature and verify if the assumptions made by BREB hold under various weather conditions and over different canopies testing the basic requirements of the BREB method use. Finally we devised a technique improving data selection for subsequent ET calculation. This study was funded by project "Building up a multidisciplinary scientific team focused on drought" No. CZ.1.07/2.3.00/20.0248,PASED - project supported by Czech program KONTAKT II No. LH12037 "Development of models for assessment of abiotic stresses in selected bioenergy plants" and LD130030 project supporting COST action ES1106.

  10. Exploring the Tropical Land-Ocean Convective Intensity Difference through Surface Bowen Ratio and Island Size Variations

    Science.gov (United States)

    Hansen, Z.; Back, L. E.

    2014-12-01

    A better understanding of the mean distribution and variability in convective patterns is important for improving our understanding of the climate system. General circulation models (GCMs) still have trouble simulating climate variability in the tropics, where deep convection plays an important role in determining the mean climate and its variability. It has been observed that lightning flash rates over land in the tropics are orders of magnitude higher than those over the ocean. Because higher lightning flash rates tend to be associated with higher updraft velocities, deep convective updrafts over land are expected to be stronger than those over the tropical oceans. We hope to elucidate the physical mechanisms that influence updraft intensity using a cloud resolving model (CRM), which, unlike a GCM, is able to explicitly simulate individual convective updrafts. There are numerous hypotheses regarding what causes the discrepancy between land and ocean convection in the tropics. The hypotheses that we explore are variations in the Surface Bowen Ratio (SBR), as well as the existence of horizontal heterogeneities interacting with an ocean. We test these hypotheses in two different contexts: initial condition simulations, and radiative convective equilibrium (RCE) simulations. We modified the SBR of a region in RCE which by extension changes its boundary layer depth. The expectation in this case was that higher SBRs would lead to more enhanced convection. However, we find that higher SBRs have no effect or a slightly negative effect on updraft statistics in RCE simulations. We also looked at how the inclusion of differently sized islands affected convection in initial condition simulations. Previously, there had been discussion of a resonant island size that may produce more intense convection (Robinson, Sherwood, and Li 2008; Robinson et al. 2011,). We were able to reproduce predicted variations in convective intensity using differently sized islands. It remains to be

  11. 论谭恩美与东方主义%On Amy Tan and Orientalism

    Institute of Scientific and Technical Information of China (English)

    陈学芬

    2016-01-01

    In the era of globalization, there is still Orientalism. A series of novels of Amy Tan sometimes follow Orientalism conventionality, sometimes beyond it. Besides she is influenced by the western tradition of Orientalism, reasons of follow Orientalism also have catering to the western readers’ imagination of exotic, to meet the market demand;And due to miscommunication between east and west. The reasons of surpassing Orientalism mainly include the following:one is that the identity of the Chinese American makes her learn more about what is the real east than whites;the second is Amy tan try to resist cultural hegemony, rewrite the east of her idea;the third is the desire and drive of the innovation. Only surpassing Orientalism, can we better deal with relationship between east and west, live in peace.%全球化时代,依然有东方主义。谭恩美的系列小说有时因袭东方主义,有时又超越。因袭的原因除了有受西方传统的东方主义的影响外,还有为了迎合西方读者对异域的想象,满足市场需求;以及东西方交流不畅造成的。超越东方主义的原因主要有以下几点:一是华裔的身份使她比白人更了解真实的东方究竟是什么样子;二是谭恩美试图反抗文化霸权,重写心目中的东方;三是创新的渴望和驱动。只有超越东方主义,才能更好地处理东西方关系,和平相处。

  12. Energy budget measurements using eddy correlation and Bowen ratio techniques at the Kinosheo Lake tower site during the Northern Wetlands Study

    Science.gov (United States)

    Den Hartog, G.; Neumann, H. H.; King, K. M.; Chipanshi, A. C.

    1994-01-01

    Fluxes of heat and water vapor were measured on a 20-m tower at Kinosheo Lake in the Hudson Bay lowlands using eddy correlation and Bowen ratio energy balance techniques. The study period was June 25 to July 28, 1990. Measurements were made over a peat bog consisting of a mixture of sphagnum moss and lichen hummocks and black pools. About 200 m west of the tower were several shallow ponds. The hummocks had a dry, insulating surface and were underlain by an ice layer near 50 cm depth until mid-July. At the beginning of the period the black pools were covered with water, and although the free water gradually disappeared over the study period, they remained saturated to the end of July. The depth of peat near the tower was about 3 m. Despite the ice layer under the hummocks, their daytime surface temperatures were high, near 35 C, and after the middle of July, above 40 C. Inspection of temperature, precipitation, and radiation data showed that the midsummer period of 1990 was warmer, drier, and sunnier than usual at Moosonee and so by influence at Lake Kinosheo. When all the data were combined to yield average diurnal energy balance components, the eddy correlation fluxes accounted for 90% of the available energy. Latent heat flux averaged 46% of the total available energy and the sensible heat flux averaged 34%. Daytime Bowen ratios were near 1 for the experimental period, suggesting that the bog behaved more like a dryland than a wetland. Eddy correlation measurements of sensible heat and latent heat flux were less than those measured using the Bowen ratio energy balance technique, the average ratios being 0.81 and 0.86 respectively. These differences were possibly due to the difficulty in measuring energy balance components of net radiation and ground heat flux over the mosaic surface.

  13. Ground observation and AMIE-TIEGCM modeling of a large-scale traveling ionospheric disturbance

    Science.gov (United States)

    Shiokawa, K.; Lu, G.; Nishitani, N.; Sato, N.

    We show comparison of ground observation and modeling of a prominent large-scale traveling ionospheric disturbance (LSTID) observed in Japan during the major magnetic storm of March 31, 2001 (Shiokawa et al., JGR, 2003). The LSTID was detected as an enhancement of the 630-nm airglow intensity, an enhancement of GPS-TEC, a decrease of F-layer virtual height, and an increase of foF2. They moved equatorward with a velocity of 400-500 m/s. These results suggest that an enhancement of poleward neutral wind (propagating equatorward as a traveling atmospheric wave) caused the observed ionospheric features of the LSTID. The ion drift measurement by the MU radar and Doppler wind measurement by a Fabry-Perot interferometer (630-nm and 558-nm airglow) at Shigaraki actually showed poleward wind enhancement during the LSTID event. To model this LSTID event, we used the assimilative mapping of ionospheric electrodynamics (AMIE) technique as inputs to the thermosphere-ionosphere-electrodynamics general circulation model (TIEGCM). The model shows fine structures of the poleward wind enhancement both propagated from the auroral zone and generated directly at midlatitudes.

  14. Evaluation of free and immobilized Aspergillus niger NRC1ami pectinase applicable in industrial processes.

    Science.gov (United States)

    Esawy, Mona A; Gamal, Amira A; Kamel, Zeinat; Ismail, Abdel-Mohsen S; Abdel-Fattah, Ahmed F

    2013-02-15

    The Aspergillus niger NRC1ami pectinase was evaluated according to its hydrolysis efficiency of dry untreated orange peels (UOP), HCl-treated orange peels and NaOH-treated orange peels (HOP and NOP). Pectinase was entrapped in polyvinyl alcohol (PVA) sponge and the optimum pH and temperature of the free and immobilized enzymes were shifted from 4, 40 °C to 6, 50 °C respectively. The study of pH stability of free and immobilized pectinase showed that the immobilization process protected the enzyme strongly from severe alkaline pHs. The immobilization process improved the enzyme thermal stability to great instant. The unique feature of the immobilization process is its ability to solve the orange juice haze problem completely. Immobilized enzyme was reused 12 times in orange juice clarification with 9% activity loss from the original activity. Maximum reaction rate (V(max)) and Michaelis-Menten constant (K(m)) of the partially purified form were significantly changed after immobilization.

  15. The Animals Reader: The Essential Classic and Contemporary Writings (Linda Kalof y Amy Fitzgerald, Eds.

    Directory of Open Access Journals (Sweden)

    Beto Vianna

    2009-01-01

    Full Text Available Las propuestas explicativas de la sociobiología y, aún más recientemente, de la psicología evolucionista han suscitado la queja, entre los científicos humanos, de una “colonización de las ciencias sociales” (término de Rose, 2000 desde la biología. La queja es legítima, si no por otros motivos, por una lamentable tendencia a la simplificación de las intricadas redes conductuales humanas a través de “explicaciones evolutivas”. Pero no podemos olvidar que hay un movimiento de igual tamaño e impacto desde las ciencias sociales que, a ejemplo de Bruno Latour, Tim Ingold y tantos otros, “colonizan” los estudios y objetos naturales (ver, por ejemplo, Latour, 1996 e Ingold, 2008. En The Animals Reader, dos sociólogas - Linda Kalof, de la Universidad del Estado de Michigan, y Amy Fitzgerald, de la Universidade de Windsor, Canada - son las responsables de hacer una incursión en un territorio tradicionalmente natural y, por tanto, perteneciente a las ciencias de la naturaleza: las descripciones que hacemos y las relaciones que mantenemos con los animales. The Animals Reader es una compilación bien cuidada, pienso que la primera de su tipo, que da forma a una preocupación multidisciplinar: los “estudios animales”.

  16. The Politics of Transnational Memory in Amy Tan’s The Joy Luck Club

    Directory of Open Access Journals (Sweden)

    Silvia Schultermandl

    2011-12-01

    Full Text Available “The Politics of Transnational Memory in Amy Tan’s The Joy Luck Club” sees Tan’s representation of memory as either a function of loss (and limited recovery or of distance (whether temporal or physical. For Schultermandl, the text suggests that familial or national relationships built on generational and immigrant memory cannot really create conditions of solidarity or identification and are thus doomed to failure—either that, or what is “memory” must be transformed by “experience” and then be understood, what Schultermandl calls “belated memory.” Schultermandl offers an account of the failure of the narrative to provide for a bond between the generations of women—immigrant mothers and American-born daughters. This conceptual problem is represented by the novel’s end, where the overriding implication of the narrative is that in order to reconcile and occupy the identity of a Chinese American one must somehow be both Chinese and American, an experience of being that Schultermandl questions. Additionally, in not representing modern China or modern Chinese women, Schultermandl argues, the novel gives up an opportunity to create a “transnational solidarity” among women in favor of a national identity that supersedes the individual, who in Tan’s text becomes a mere stand-in for traditionally held ideological and national stereotypes.

  17. Reduction of Driver Stress Using AmI Technology while Driving in Motorway Merging Sections

    Science.gov (United States)

    Zia, Kashif; Riener, Andreas; Ferscha, Alois

    High average intensity of traffic and problems like traffic congestions, road safety, etc. are challenging problems striking highway operators in these days. With the broad application of intelligent transport systems (ITS), particularly for the most dense street sections, some of these problems can be minimized or even solved; supplementary great potential is attributed to applications based on state-of-the art technology like car-to-x communication, for instance by extending an individuals "field of vision" by observations taken from all the vehicles in front. In this work we present a simulation based approach for improving driving experience and increasing road safety in merging sections by redirecting vehicles in advance according to a negotiation of requirements and desires of the flowing traffic on the main road and cars merging from the entrance lane. The simulation experiments performed in a cellular automaton based environment were data driven and on real scale, using traffic flow data on a minute-by-minute basis from a large urban motorway in a main city of the European Union. Our results have shown that the application of AmI technology has potential to influence driver's behavior (seamlessly invoking for a lane change well before an abrupt merging point) resulting in a reduction of panic, particularly for sections with limited range of view.

  18. Off-line tracking of series parameters in distribution systems using AMI data

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Tess L.; Sun, Yannan; Schneider, Kevin

    2016-05-01

    Electric distribution systems have historically lacked measurement points, and equipment is often operated to its failure point, resulting in customer outages. The widespread deployment of sensors at the distribution level is enabling observability. This paper presents an off-line parameter value tracking procedure that takes advantage of the increasing number of measurement devices being deployed at the distribution level to estimate changes in series impedance parameter values over time. The tracking of parameter values enables non-diurnal and non-seasonal change to be flagged for investigation. The presented method uses an unbalanced Distribution System State Estimation (DSSE) and a measurement residual-based parameter estimation procedure. Measurement residuals from multiple measurement snapshots are combined in order to increase the effective local redundancy and improve the robustness of the calculations in the presence of measurement noise. Data from devices on the primary distribution system and from customer meters, via an AMI system, form the input data set. Results of simulations on the IEEE 13-Node Test Feeder are presented to illustrate the proposed approach applied to changes in series impedance parameters. A 5% change in series resistance elements can be detected in the presence of 2% measurement error when combining less than 1 day of measurement snapshots into a single estimate.

  19. Família e o processo de diferenciação na perspectiva de Murray Bowen: um estudo de caso

    Directory of Open Access Journals (Sweden)

    Elizabeth Medeiros de Almeida Martins

    2008-06-01

    Full Text Available Este estudo teve como objetivo investigar a aplicabilidade do conceito de diferenciação do self elaborado por Murray Bowen na terapia da família. Focalizou a história de uma família mostrando como as histórias de vida do casal, a partir das primeiras triangulações, tanto na família nuclear quanto na extensa, foram transmitidas entre gerações até gerar uma história renovada do casal e de sua própria família.

  20. Família e o processo de diferenciação na perspectiva de Murray Bowen: um estudo de caso

    OpenAIRE

    Elizabeth Medeiros de Almeida Martins; Elaine Pedreira Rabinovich; Célia Nunes Silva

    2008-01-01

    Este estudo teve como objetivo investigar a aplicabilidade do conceito de diferenciação do self elaborado por Murray Bowen na terapia da família. Focalizou a história de uma família mostrando como as histórias de vida do casal, a partir das primeiras triangulações, tanto na família nuclear quanto na extensa, foram transmitidas entre gerações até gerar uma história renovada do casal e de sua própria família.

  1. Enabling cell-cell communication via nanopore formation: structure, function and localization of the unique cell wall amidase AmiC2 of Nostoc punctiforme.

    Science.gov (United States)

    Büttner, Felix M; Faulhaber, Katharina; Forchhammer, Karl; Maldener, Iris; Stehle, Thilo

    2016-04-01

    To orchestrate a complex life style in changing environments, the filamentous cyanobacterium Nostoc punctiforme facilitates communication between neighboring cells through septal junction complexes. This is achieved by nanopores that perforate the peptidoglycan (PGN) layer and traverse the cell septa. The N-acetylmuramoyl-l-alanine amidase AmiC2 (Npun_F1846; EC 3.5.1.28) in N. punctiforme generates arrays of such nanopores in the septal PGN, in contrast to homologous amidases that mediate daughter cell separation after cell division in unicellular bacteria. Nanopore formation is therefore a novel property of AmiC homologs. Immunofluorescence shows that native AmiC2 localizes to the maturing septum. The high-resolution crystal structure (1.12 Å) of its catalytic domain (AmiC2-cat) differs significantly from known structures of cell splitting and PGN recycling amidases. A wide and shallow binding cavity allows easy access of the substrate to the active site, which harbors an essential zinc ion. AmiC2-cat exhibits strong hydrolytic activity in vitro. A single point mutation of a conserved glutamate near the zinc ion results in total loss of activity, whereas zinc removal leads to instability of AmiC2-cat. An inhibitory α-helix, as found in the Escherichia coli AmiC(E. coli) structure, is absent. Taken together, our data provide insight into the cell-biological, biochemical and structural properties of an unusual cell wall lytic enzyme that generates nanopores for cell-cell communication in multicellular cyanobacteria. The novel structural features of the catalytic domain and the unique biological function of AmiC2 hint at mechanisms of action and regulation that are distinct from other amidases. The AmiC2-cat structure has been deposited in the Protein Data Bank under accession number 5EMI. © 2016 Federation of European Biochemical Societies.

  2. Differences in AMY1 Gene Copy Numbers Derived from Blood, Buccal Cells and Saliva Using Quantitative and Droplet Digital PCR Methods: Flagging the Pitfall

    Science.gov (United States)

    Ong, Siong Gim; Chan, Yiong Huak; Heng, Chew Kiat

    2017-01-01

    Introduction The human salivary (AMY1) gene, encoding salivary α-amylase, has variable copy number variants (CNVs) in the human genome. We aimed to determine if real-time quantitative polymerase chain reaction (qPCR) and the more recently available Droplet Digital PCR (ddPCR) can provide a precise quantification of the AMY1 gene copy number in blood, buccal cells and saliva samples derived from the same individual. Methods Seven participants were recruited and DNA was extracted from the blood, buccal cells and saliva samples provided by each participant. Taqman assay real-time qPCR and ddPCR were conducted to quantify AMY1 gene copy numbers. Statistical analysis was carried out to determine the difference in AMY1 gene copy number between the different biological specimens and different assay methods. Results We found significant within-individual difference (p<0.01) in AMY1 gene copy number between different biological samples as determined by qPCR. However, there was no significant within-individual difference in AMY1 gene copy number between different biological samples as determined by ddPCR. We also found that AMY1 gene copy number of blood samples were comparable between qPCR and ddPCR, while there is a significant difference (p<0.01) between AMY1 gene copy numbers measured by qPCR and ddPCR for both buccal swab and saliva samples. Conclusions Despite buccal cells and saliva samples being possible sources of DNA, it is pertinent that ddPCR or a single biological sample, preferably blood sample, be used for determining highly polymorphic gene copy numbers like AMY1, due to the large within-individual variability between different biological samples if real time qPCR is employed. PMID:28125683

  3. AMI observations of ten CLASH galaxy clusters: SZ and X-ray data used together to determine cluster dynamical states

    CERN Document Server

    Rumsey, Clare; Perrott, Yvette C; Russell, Helen R; Feroz, Farhan; Grainge, Keith J B; Handley, Will J; Hobson, Michael P; Saunders, Richard D E; Schammel, Michel P

    2016-01-01

    Using Arcminute Microkelvin Imager (AMI) SZ observations towards ten CLASH clusters we investigate the influence of cluster mergers on observational galaxy cluster studies. Although selected to be largely relaxed, there is disagreement in the literature on the dynamical states of CLASH sample members. We analyse our AMI data in a fully Bayesian way to produce estimated cluster parameters and consider the intrinsic correlations in our NFW/GNFW-based model. Varying pressure profile shape parameters, illustrating an influence of mergers on scaling relations, induces small deviations from the canonical self-similar predictions -- in agreement with simulations of Poole et al. 2007 who found that merger activity causes only small scatter perpendicular to the relations. We demonstrate this effect observationally using the different dependencies of SZ and X-ray signals to $n_{\\rm e}$ that cause different sensitivities to the shocking and/or fractionation produced by mergers. Plotting $Y_{\\rm X}$--$M_{\\rm gas}$ relati...

  4. Geometrical Analysis of AMIE/Smart-1 Images and Applications to Photometric Studies of the Lunar Surface

    Science.gov (United States)

    Despan, Daniela; Erard, S.; Barucci, M. A.; Josset, J. L.; Beauvivre, S.; Chevrel, S.; Pinet, P.; Koschny, D.; Almeida, M.; Foing, B. H.; AMIE Team

    2007-10-01

    AMIE, the Advanced Moon micro-Imager Experiment on board the ESA lunar mission SMART-1, is an imaging system to survey the terrain in visible and near-infrared light. AMIE provides high resolution images obtained using a tele-objective with 5.3° x 5.3° field of view and a sensor of 1024 x 1024 pixels. The output images have resolution 45m/pixel at 500km, and are encoded with 10 bits/pixel. From the 300 Km pericenter altitude, the same field of view corresponds to a spatial resolution about 30 m/pixel. The FOV is shared by various filters, allowing to reconstruct mosaics of the surface in 3 colors, depending on pointing mode. Spot-pointing observations provide photometric sequences that allow to study the surface properties in restricted areas. One of the scientific objectives of the mission is to get high resolution imaging of the Moon surface, e.g. high latitude regions in the southern hemisphere. In order to map the lunar surface with AMIE, systematic analysis and processing is being carried on using the whole data set. Geometrical analysis of AMIE images relies on the SPICE system: image coordinates are computed to get precise projection at the surface, and illumination angles are computed to analyze the photometric sequences. High resolution mosaics were constructed then compared to lower resolution Clementine UV-Vis and NIR images. Spot-pointing sequences are used to constrain the photometric and physical properties of surface materials in areas of interest, based on Hapke's modeling. Optical alignment parameters in the Spice kernels have been refined and provide absolute coordinates in the IAU lunar frame (ULCN). They provide discrepancies with the Clementine basemap, ranging up to some 0.1° in the equatorial regions, as expected (e.g., Cook et al DPS 2002; Arcinal et al. EPSC 2006). A progress report will be presented at the conference.

  5. AMI observations of 10 CLASH galaxy clusters: SZ and X-ray data used together to determine cluster dynamical states

    Science.gov (United States)

    Rumsey, Clare; Olamaie, Malak; Perrott, Yvette C.; Russell, Helen R.; Feroz, Farhan; Grainge, Keith J. B.; Handley, Will J.; Hobson, Michael P.; Saunders, Richard D. E.; Schammel, Michel P.

    2016-07-01

    Using Arcminute Microkelvin Imager (AMI) Sunyaev-Zel'dovich (SZ) observations towards 10 CLASH (Cluster Lensing and Supernova Survey with Hubble) clusters, we investigate the influence of cluster mergers on observational galaxy cluster studies. Although selected to be largely relaxed, there is disagreement in the literature on the dynamical states of CLASH sample members. We analyse our AMI data in a fully Bayesian way to produce estimated cluster parameters and consider the intrinsic correlations in our Navarro, Frenk and White/generalized Navarro, Frenk and White-based model. Varying pressure profile shape parameters, illustrating an influence of mergers on scaling relations, induces small deviations from the canonical self-similar predictions - in agreement with simulations of Poole et al. (2007) who found that merger activity causes only small scatter perpendicular to the relations. We demonstrate this effect observationally using the different dependences of SZ and X-ray signals to ne that cause different sensitivities to the shocking and/or fractionation produced by mergers. Plotting YX-Mgas relations (where YX = MgasT) derived from AMI SZ and from Chandra X-ray gives ratios of AMI and Chandra YX and Mgas estimates that indicate movement of clusters along the scaling relation, as predicted by Poole et al. (2007). Clusters that have moved most along the relation have the most discrepant TSZ and TX estimates: all the other clusters (apart from one) have SZ and X-ray estimates of Mgas, T and YX that agree within r500. We use SZ versus X-ray discrepancies in conjunction with Chandra maps and TX profiles, making comparisons with simulated cluster merger maps in Poole et al. (2006) to identify disturbed members of our sample and estimate merger stages.

  6. SZ observations with AMI of the hottest galaxy clusters detected in the XMM-Newton Cluster Survey

    CERN Document Server

    :,; Rodriguez-Gonzalvez, Carmen; Feroz, Farhan; Franzen, Thomas M O; Grainge, Keith J B; Hobson, Michael P; Hurley-Walker, Natasha; Lasenby, Anthony N; Lloyd-Davies, E J; Olamaie, Malak; Perrott, Yvette C; Pooley, Guy G; Rumsey, Clare; Romer, A Kathy; Saunders, Richard D E; Scaife, Anna M M; Schammel, Michel P; Scott, Paul F; Titterington, David J; Waldram, Elizabeth M

    2013-01-01

    We have obtained deep SZ observations towards 15 of the apparently hottest XMM Cluster Survey (XCS) clusters that can be observed with the Arcminute Microkelvin Imager (AMI). We use a Bayesian analysis to quantify the significance of our SZ detections. We detect the SZ effect at high significance towards three of the clusters and at lower significance for a further two clusters. Towards the remaining ten clusters, no clear SZ signal was measured. We derive cluster parameters using the XCS mass estimates as a prior in our Bayesian analysis. For all AMI-detected clusters, we calculate large-scale mass and temperature estimates while for all undetected clusters we determine upper limits on these parameters. We find that the large- scale mean temperatures derived from our AMI SZ measurements (and the upper limits from null detections) are substantially lower than the XCS-based core-temperature estimates. For clusters detected in the SZ, the mean temperature is, on average, a factor of 1.4 lower than temperatures ...

  7. Radar observations of MJO and Kelvin wave interactions during DYNAMO/CINDY2011/AMIE

    Science.gov (United States)

    DePasquale, Amanda; Schumacher, Courtney; Rapp, Anita

    2014-06-01

    Radar and sounding data collected during the Dynamics of the Madden-Julian Oscillation (DYNAMO), the Cooperative Indian Ocean Experiment on Intraseasonal Variability in the Year 2011 (CINDY2011), and the Atmospheric Radiation Measurement (ARM) Madden-Julian Oscillation Investigation Experiment (AMIE) field campaigns in the equatorial Indian Ocean to study the initiation of the Madden-Julian Oscillation (MJO) are used to examine the precipitation, cloud, and moisture characteristics during the MJO and convectively coupled Kelvin waves (KWs). Three MJO events and 10 KWs were identified from satellite data using different wave number frequency filters, although event identification varied based on the chosen range of latitude, frequency, and outgoing longwave radiation threshold. Radar and sounding data were composited for the three MJO events, four KWs during the active MJO, five KWs during the suppressed MJO, and one KW during the developing MJO. The MJO composite was generally consistent with past studies, although an increase in convective rain appeared to precede relative humidity increases at low- to middle-levels. The active and developing MJO KWs produced more rain and cloud than suppressed MJO KWs and had a secondary peak in stratiform rain potentially associated with subsynoptic-scale cloud clusters. The suppressed MJO KW composite displayed previously documented structure of vertical moisture buildup prior to the KW passage, whereas the developing MJO KW did not. The KW moisture signature during the active MJO was somewhat overwhelmed by the moist environment associated with the active MJO. Upper level moisture was enhanced after KW passage, regardless of MJO phase. However, upper level moisture was most enhanced after the developing MJO KW passage, providing deep tropospheric moisture that may have assisted MJO onset. Nonprecipitating upper level cloud and midlevel altocumulus/altostratus also persisted after most KW passages.

  8. Stratiform and Convective Precipitation Observed by Multiple Radars during the DYNAMO/AMIE Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Min; Kollias, Pavlos; Feng, Zhe; Zhang, Chidong; Long, Charles N.; Kalesse, Heike; Chandra, Arunchandra; Kumar, Vickal; Protat, Alain

    2014-11-01

    The motivation for this research is to develop a precipitation classification and rain rate estimation method using cloud radar-only measurements for Atmospheric Radiation Measurement (ARM) long-term cloud observation analysis, which are crucial and unique for studying cloud lifecycle and precipitation features under different weather and climate regimes. Based on simultaneous and collocated observations of the Ka-band ARM zenith radar (KAZR), two precipitation radars (NCAR S-PolKa and Texas A&M University SMART-R), and surface precipitation during the DYNAMO/AMIE field campaign, a new cloud radar-only based precipitation classification and rain rate estimation method has been developed and evaluated. The resulting precipitation classification is equivalent to those collocated SMART-R and S-PolKa observations. Both cloud and precipitation radars detected about 5% precipitation occurrence during this period. The convective (stratiform) precipitation fraction is about 18% (82%). The 2-day collocated disdrometer observations show an increased number concentration of large raindrops in convective rain compared to dominant concentration of small raindrops in stratiform rain. The composite distributions of KAZR reflectivity and Doppler velocity also show two distinct structures for convective and stratiform rain. These indicate that the method produces physically consistent results for two types of rain. The cloud radar-only rainfall estimation is developed based on the gradient of accumulative radar reflectivity below 1 km, near-surface Ze, and collocated surface rainfall (R) measurement. The parameterization is compared with the Z-R exponential relation. The relative difference between estimated and surface measured rainfall rate shows that the two-parameter relation can improve rainfall estimation.

  9. Radiative Energetics of Mineral Dust Aerosol over Zhangye China during the AMY 2008 Field Campaign

    Science.gov (United States)

    Hansell, R. A.; Tsay, S.; Ji, Q.; Hsu, C.; Bell, S.; Li, C.; Wang, C.

    2010-12-01

    In support of the DOE ARM program, NASA Goddard’s mobile ground-based laboratories (SMART-COMMIT) were deployed to Zhangye China (39.082°N; 100.276°E) from April-June 2008 as an ARM Ancillary Facility (AAF) to support the Asian Monsoon Year (AMY) field study. The primary objective at Zhangye, a semi-arid region located between the Taklimakan and Gobi deserts, was to both capture and characterize dust aerosol near the source region and to determine its direct aerosol radiative effects (DARE). To facilitate this study, the AAF’s Atmospheric Emitted Radiance Interferometer (AERI), a key instrument for spectrally characterizing the thermal IR, is employed to retrieve the daytime/nighttime dust IR aerosol optical thickness (AOT) for several notable dust events. Regional dust microphysical and mineralogy measurements are also used for developing a representative aerosol optical model of dust single-scattering properties. The retrieved AOT are then inputted into a 1-D radiative transfer model constrained by local measurements to evaluate dust’s local instantaneous shortwave (SW) and longwave (LW) DARE at the surface and top of the atmosphere (TOA) along with the heating rate profiles under cloud-free atmospheres. Comparisons of the SW DARE are made with a previous study over the same area using broadband data from thermal dome effect corrected pyranometers and the significance of the LW effects relative to the SW is examined. This study is part of an on-going effort to complete a global assessment of dust DARE for the major dust source regions of the world.

  10. A broader role for AmyR in Aspergillus niger: regulation of the utilisation of D-glucose or D-galactose containing oligo- and polysaccharides.

    Science.gov (United States)

    vanKuyk, Patricia A; Benen, Jaques A E; Wösten, Han A B; Visser, Jaap; de Vries, Ronald P

    2012-01-01

    AmyR is commonly considered a regulator of starch degradation whose activity is induced by the presence of maltose, the disaccharide building block of starch. In this study, we demonstrate that the role of AmyR extends beyond starch degradation. Enzyme activity assays, genes expression analysis and growth profiling on D-glucose- and D-galactose-containing oligo- and polysaccharides showed that AmyR regulates the expression of some of the Aspergillus niger genes encoding α- and β-glucosidases, α- and β- galactosidases, as well as genes encoding α-amlyases and glucoamylases. In addition, we provide evidence that D-glucose or a metabolic product thereof may be the inducer of the AmyR system in A. niger and not maltose, as is commonly assumed.

  11. The incidence and risk factors of associated acute myocardial infarction (AMI in acute cerebral ischemic (ACI events in the United States.

    Directory of Open Access Journals (Sweden)

    Ali Seifi

    Full Text Available OBJECTIVES: To determine the association between myocardial infarction (AMI and clinical outcome in patients with primary admissions diagnosis of acute cerebral ischemia (ACI in the US. METHODS: Data from Nationwide Inpatient Sample (NIS was queried from 2002-2011 for inpatient admissions of patients with a primary diagnosis of ACI with and without AMI using International Classification of Diseases, Ninth Revision, Clinical Modification coding (ICD-9. A multivariate stepwise regression analysis was performed to assess the correlation between identifiable risk factors and clinical outcomes. RESULTS: During 10 years the NIS recorded 886,094 ACI admissions with 17,526 diagnoses of AMI (1.98%. The overall cumulative mortality of cohort was 5.65%. In-hospital mortality was associated with AMI (aOR 3.68; 95% CI 3.49-3.88, p≤0.0001, rTPA administration (aOR 2.39 CI, 2.11-2.71, p<0.0001, older age (aOR 1.03, 95% CI, 1.03-1.03, P<0.0001 and women (aOR 1.06, 95% CI 1.03-1.08, P<0.0001. Overall, mortality risk declined over the course of study; from 20.46% in 2002 to 11.8% in 2011 (OR 0.96, 95% CI 0.95-0.96, P<0.0001. Survival analysis demonstrated divergence between the AMI and non-AMI sub-groups over the course of study (log-rank p<0.0001. CONCLUSION: Our study demonstrates that although the prevalence of AMI in patients hospitalized with primary diagnosis of ACI is low, it negatively impacts survival. Considering the high clinical burden of AMI on mortality of ACI patients, a high quality monitoring in the event of cardiac events should be maintained in this patient cohort. Whether prompt diagnosis and treatment of associated cardiovascular diseases may improve outcome, deserves further study.

  12. Lunar swirls as possible targets for the AMIE/SMART-1 mission

    Science.gov (United States)

    Shevchenko, V.

    as a swirl of the same type as Reiner Gamma. Moreover, photometric and spectral properties of the swirl formations are very similar. Preliminary estimations of the swirl age show that Reiner Gamma formation and the swirl formation placed inside crater Gerasimovich are very young lunar features and they appeared about 107 years ago. Nature and origin of the swirl formations are open questions in lunar science. Investigation of them could be a good science objective for AMIE/SMART-1 mission.

  13. Anti-microbial coating innovations to prevent infectious diseases (AMiCI): Cost action ca15114.

    Science.gov (United States)

    Dunne, Colum P; Keinänen-Toivola, Minna M; Kahru, Anne; Teunissen, Birgit; Olmez, Hulya; Gouveia, Isabel; Melo, Luis; Murzyn, Kazimierz; Modic, Martina; Ahonen, Merja; Askew, Pete; Papadopoulos, Theofilos; Adlhart, Christian; Crijns, Francy R L

    2017-04-28

    Worldwide, millions of patients are affected annually by healthcare-associated infection (HCAI), impacting up to 80,000 patients in European Hospitals on any given day. This represents not only public health risk, but also an economic burden. Complementing routine hand hygiene practices, cleaning and disinfection, antimicrobial coatings hold promise based, in essence, on the application of materials and chemicals with persistent bactericidal or -static properties onto surfaces or in textiles used in healthcare environments. The focus of considerable commercial investment and academic research energies, such antimicrobial coating-based approaches are widely believed to have potential in reduction of microbial numbers on surfaces in clinical settings. This belief exists despite definitive evidence as to their efficacy and is based somewhat on positive studies involving, for example, copper, silver or gold ions, titanium or organosilane, albeit under laboratory conditions. The literature describes successful delay and/or prevention of recontamination following conventional cleaning and disinfection by problematic microbes such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE), among others. However, there is a scarcity of studies assessing antimicrobial surfaces other than copper in the clinical environment, and a complete lack of published data regarding the successful implementation of these materials on clinically significant outcomes (including HCAI). Through its Cooperation in Science and Technology program (COST), the European Commission has funded a 4-year initiative to establish a network of stakeholders involved in development, regulation and use of novel anti-microbial coatings for prevention of HCAI. The network (AMiCI) comprises participants of more than 60 universities, research institutes and companies across 29 European countries and, to-date, represents the most comprehensive consortium targeting use of

  14. Estimating evapotranspiration using remote sensing: A hybrid approach between MODIS derived enhanced vegetation index, Bowen ratio system, and ground based micro-meteorological data

    Science.gov (United States)

    Chatterjee, Sumantra

    We investigated water loss by evapotranspiration (ET) from the Palo Verde Irrigation District (PVID) and the Cibola National Wildlife Refuge (CNWR) in southern California bordering the Colorado River collaborating with the United States Bureau of Reclamation (U.S.B.R.). We developed an empirical model to estimate ET for the entire PVID using satellite derived MODIS enhanced vegetation index (EVI), and ground based measurements of solar radiation and vapor pressure. We compared our predictions with U.S.B.R. estimates through statistical cross validation and showed they agree with an error less than 8%. We tested the same model for an alfalfa field inside PVID to check its applicability at a smaller spatial scale. We showed that the same model developed for PVID is the best model for estimating ET for the alfalfa field. We collected data from three Bowen ratio energy balance (BREB) towers installed in the invasive saltcedar (Tamarix spp) dominated riparian zone in the CNWR and a fourth tower in the alfalfa field in PVID. The riparian sites were selected according to different densities of vegetation. We collected data from these sites at various intervals during the period between June 2006 to November 2008. We reduced the errors associated with the Bowen ratio data using statistical procedures taking into account occasional instrument failures and problems inherent in the BREB method. Our results were consistent with vegetation density and estimates from MODIS EVI images. To estimate ET for larger patches of mixed vegetation we modified the crop coefficient equation and represented it in terms of EVI. Using this approach, we scaled the alfalfa field data to the entire PVID and compared the results with U.S.B.R. (2001-2007) estimates. We predicted ET well within the acceptable range established in the literature. We empirically developed ET models for the riparian tower sites to provide accurate point scale ET estimation and scaled for the entire riparian region in

  15. Papulose bowenóide: um aspecto clínico da infecção pelo HPV Bowenoid papulosis: a clinical feature of the HPV infection

    Directory of Open Access Journals (Sweden)

    Sidney Roberto Nadal

    2009-12-01

    Full Text Available Papulose bowenóide é uma doença que acomete a pele da região anogenital e que se caracteriza pelas múltiplas pequenas pápulas planas ou aveludadas e de coloração que varia do róseo ao castanho-escuro. É provocada pelo HPV e a transmissão sexual é a forma mais freqüente de contaminação. As queixas mais comuns são prurido e dor. O aspecto é característico e o exame histopatológico confirma o diagnóstico. Junto com a doença de Bowen e a eritroplasia de Queyrat, é considerada como carcinoma in situ, ou neoplasia intra-epitelial de alto grau (NIAA, a lesão precursora do carcinoma espinocelular (CEC anal. Sem tratamento, a maioria das lesões permanece benigna e estável. Várias modalidades terapêuticas estão disponíveis, incluindo as medicações tópicas para citodestruição e as técnicas ablativas. Os esquemas tópicos são efetivos. Cabe ao profissional médico escolher a terapia adequada, tendo em mente que a doença é benigna e raramente evolui para carcinoma. Como as recidivas são freqüentes e ainda persistem dúvidas quanto ao potencial de malignização, os doentes devem ser examinados periodicamente para diagnosticar as lesões iniciais.Bowenoid papulosis is an anogenital skin disease characterized by multiple little papules, flat or velvet, which color varies from pink to dark brown. It is provoked by HPV and its transmission is sexual. Most common symptoms are anal pain and itching. Its appearance is characteristic and hystopathological examination confirms diagnosis. Together with Bowen´s disease and Queyrat erythroplasia, is considered as an in situ carcinoma, or high grade intra-epithelial neoplasia (HAIN, a precursor of the squamous-cell carcinoma. Most of lesions remain benign and stable without treatment. There are several kinds of treatment including topical drugs for cytodestruction and ablative techniques. Topic schemes are effectives. The consultant doctor may choose the most adequate therapy

  16. Limnological Conditions and Occurrence of Taste-and-Odor Compounds in Lake William C. Bowen and Municipal Reservoir #1, Spartanburg County, South Carolina, 2006-2009

    Science.gov (United States)

    Journey, Celeste A.; Arrington, Jane M.; Beaulieu, Karen M.; Graham, Jennifer L.; Bradley, Paul M.

    2011-01-01

    Limnological conditions and the occurrence of taste-and-odor compounds were studied in two reservoirs in Spartanburg County, South Carolina, from May 2006 to June 2009. Lake William C. Bowen and Municipal Reservoir #1 are relatively shallow, meso-eutrophic, warm monomictic, cascading impoundments on the South Pacolet River. Overall, water-quality conditions and phytoplankton community assemblages were similar between the two reservoirs but differed seasonally. Median dissolved geosmin concentrations in the reservoirs ranged from 0.004 to 0.006 microgram per liter. Annual maximum dissolved geosmin concentrations tended to occur between March and May. In this study, peak dissolved geosmin production occurred in April and May 2008, ranging from 0.050 to 0.100 microgram per liter at the deeper reservoir sites. Peak dissolved geosmin production was not concurrent with maximum cyanobacterial biovolumes, which tended to occur in the summer (July to August), but was concurrent with a peak in the fraction of genera with known geosmin-producing strains in the cyanobacteria group. Nonetheless, annual maximum cyanobacterial biovolumes rarely resulted in cyanobacteria dominance of the phytoplankton community. In both reservoirs, elevated dissolved geosmin concentrations were correlated to environmental factors indicative of unstratified conditions and reduced algal productivity, but not to nutrient concentrations or ratios. With respect to potential geosmin sources, elevated geosmin concentrations were correlated to greater fractions of genera with known geosmin-producing strains in the cyanobacteria group and to biovolumes of a specific geosmin-producing cyanobacteria genus (Oscillatoria), but not to actinomycetes concentrations. Conversely, environmental factors that correlated with elevated cyanobacterial biovolumes were indicative of stable water columns (stratified conditions), warm water temperatures, reduced nitrogen concentrations, longer residence times, and high

  17. Individual differences in AMY1 gene copy number, salivary α-amylase levels, and the perception of oral starch.

    Directory of Open Access Journals (Sweden)

    Abigail L Mandel

    Full Text Available BACKGROUND: The digestion of dietary starch in humans is initiated by salivary α-amylase, an endo-enzyme that hydrolyzes starch into maltose, maltotriose and larger oligosaccharides. Salivary amylase accounts for 40 to 50% of protein in human saliva and rapidly alters the physical properties of starch. Importantly, the quantity and enzymatic activity of salivary amylase show significant individual variation. However, linking variation in salivary amylase levels with the oral perception of starch has proven difficult. Furthermore, the relationship between copy number variations (CNVs in the AMY1 gene, which influence salivary amylase levels, and starch viscosity perception has not been explored. PRINCIPAL FINDINGS: Here we demonstrate that saliva containing high levels of amylase has sufficient activity to rapidly hydrolyze a viscous starch solution in vitro. Furthermore, we show with time-intensity ratings, which track the digestion of starch during oral manipulation, that individuals with high amylase levels report faster and more significant decreases in perceived starch viscosity than people with low salivary amylase levels. Finally, we demonstrate that AMY1 CNVs predict an individual's amount and activity of salivary amylase and thereby, ultimately determine their perceived rate of oral starch viscosity thinning. CONCLUSIONS: By linking genetic variation and its consequent salivary enzymatic differences to the perceptual sequellae of these variations, we show that AMY1 copy number relates to salivary amylase concentration and enzymatic activity level, which, in turn, account for individual variation in the oral perception of starch viscosity. The profound individual differences in salivary amylase levels and salivary activity may contribute significantly to individual differences in dietary starch intake and, consequently, to overall nutritional status.

  18. Differences in AMY1 Gene Copy Numbers Derived from Blood, Buccal Cells and Saliva Using Quantitative and Droplet Digital PCR Methods: Flagging the Pitfall.

    Science.gov (United States)

    Ooi, Delicia Shu Qin; Tan, Verena Ming Hui; Ong, Siong Gim; Chan, Yiong Huak; Heng, Chew Kiat; Lee, Yung Seng

    2017-01-01

    The human salivary (AMY1) gene, encoding salivary α-amylase, has variable copy number variants (CNVs) in the human genome. We aimed to determine if real-time quantitative polymerase chain reaction (qPCR) and the more recently available Droplet Digital PCR (ddPCR) can provide a precise quantification of the AMY1 gene copy number in blood, buccal cells and saliva samples derived from the same individual. Seven participants were recruited and DNA was extracted from the blood, buccal cells and saliva samples provided by each participant. Taqman assay real-time qPCR and ddPCR were conducted to quantify AMY1 gene copy numbers. Statistical analysis was carried out to determine the difference in AMY1 gene copy number between the different biological specimens and different assay methods. We found significant within-individual difference (pcopy number between different biological samples as determined by qPCR. However, there was no significant within-individual difference in AMY1 gene copy number between different biological samples as determined by ddPCR. We also found that AMY1 gene copy number of blood samples were comparable between qPCR and ddPCR, while there is a significant difference (pcopy numbers measured by qPCR and ddPCR for both buccal swab and saliva samples. Despite buccal cells and saliva samples being possible sources of DNA, it is pertinent that ddPCR or a single biological sample, preferably blood sample, be used for determining highly polymorphic gene copy numbers like AMY1, due to the large within-individual variability between different biological samples if real time qPCR is employed.

  19. Análise das necessidades hídricas da vegetação Tamarisk através da razão de Bowen e do modelo SEBAL Water demand analysis of the Tamarisk vegetation through of the Bowen ratio and SEBAL model

    Directory of Open Access Journals (Sweden)

    Carlos Antonio Costa dos Santos

    2011-03-01

    Full Text Available O objetivo desse estudo foi determinar a evapotranspiração real diária (ETr da vegetação tamarisk utilizando dados micrometeorológicos e o modelo SEBAL. Foram utilizados dados provenientes do método da razão de Bowen, além do modelo SEBAL aplicado a imagens do Landsat 5 - TM, na obtenção da ETr diária da vegetação tamarisk do Baixo Rio Colorado, CA/EUA. Na obtenção da evapotranspiração de referência (ET0 foi utilizado o método da FAO/Penman-Monteith. Os resultados mostram características de forte advecção de ar, e que a radiação solar é o componente de maior influência na obtenção da ET0. Verifica-se também, que a vegetação tamarisk tem alto consumo hídrico e a sua rápida expansão poderá trazer impactos negativos para os rios da região. As estimativas da ETr pelo modelo SEBAL são similares aos valores medidos na torre micrometeorológica pelo método da razão de Bowen, demonstrando a aplicabilidade do modelo SEBAL na obtenção da distribuição espacial da evapotranspiração real diária.The objective of this study was to determine the daily actual evapotranspiration (ETr of the tamarisk vegetation using micrometeorological data and SEBAL model. Data originating from the Bowen ratio method were used, besides the SEBAL model applied to TM Landsat 5 image for obtaining the daily ETr of the tamarisk vegetation of Lower Colorado River, CA/USA. For obtaining the reference evapotranspiration (ET0 the FAO/Penman-Monteith method was used. The results show characteristics of strong air advection and that the solar radiation has the largest influence in obtaining ET0, as well as, that the tamarisk vegetation has high water demand and its fast expansion can bring negative impacts for the rivers of the area. The estimates of ETr through the SEBAL model are similar to the measured values on the micrometeorological tower by the Bowen ratio method, demonstrating the applicability of the SEBAL model to obtain the spatial

  20. ENFERMEDAD DE BOWEN TRATADA CON CRIOTERAPIA COMBINADA CON IMIQUIMOD TOPICO AL 5%. TRATAMIENTO ALTERNATIVO A LA CIRUGÍA EN PACIENTES MAYORES CON CO-MORBILIDADES

    Directory of Open Access Journals (Sweden)

    Lezcano Liz

    2011-04-01

    Full Text Available Bowen's disease (BD is an in situ squamous cell carcinoma in which dysplastic changes occur throughout the full thickness of the epidermis. It usually affects fair-skinned people over 60 years. It is characterized by erythematous papules and plaques solitary or multiple, with a slow centrifugal growth. The differential diagnosis of BD should be established with chronic dermatoses such as psoriasis, chronic eczema, superficial basal cell carcinoma and Paget's disease of the skin. Only 5% of cases progress to invasive squamous cell carcinoma. We report the case of a woman of 63 years of age with BD treated with cryotherapy combined with topical 5% imiquimod who responded adequately to this combination therapy.

  1. FTT-MA: a flexible time-triggered middleware architecture for time sensitive, resource-aware AmI systems.

    Science.gov (United States)

    Noguero, Adrián; Calvo, Isidro; Pérez, Federico; Almeida, Luis

    2013-05-13

    There is an increasing number of Ambient Intelligence (AmI) systems that are time-sensitive and resource-aware. From healthcare to building and even home/office automation, it is now common to find systems combining interactive and sensing multimedia traffic with relatively simple sensors and actuators (door locks, presence detectors, RFIDs, HVAC, information panels, etc.). Many of these are today known as Cyber-Physical Systems (CPS). Quite frequently, these systems must be capable of (1) prioritizing different traffic flows (process data, alarms, non-critical data, etc.), (2) synchronizing actions in several distributed devices and, to certain degree, (3) easing resource management (e.g., detecting faulty nodes, managing battery levels, handling overloads, etc.). This work presents FTT-MA, a high-level middleware architecture aimed at easing the design, deployment and operation of such AmI systems. FTT-MA ensures that both functional and non-functional aspects of the applications are met even during reconfiguration stages. The paper also proposes a methodology, together with a design tool, to create this kind of systems. Finally, a sample case study is presented that illustrates the use of the middleware and the methodology proposed in the paper.

  2. Effects of Polymorphisms in Pepsinogen (PEP, Amylase (AMY and Trypsin (TRY Genes on Food Habit Domestication Traits in Mandarin Fish

    Directory of Open Access Journals (Sweden)

    Tilin Yi

    2013-10-01

    Full Text Available Mandarin fish (Siniperca chuatsi have a peculiar feeding habit of only accepting live fish prey and refusing dead prey and artificial diets. However, previous research has shown that some individuals accept dead prey after gradual domestication. Digestive enzymes are correlated with feeding habits in fish. In the current study, SNPs in the mandarin fish genes for pepsinogen (PEP, amylase (AMY, and trypsin (TRY were evaluated for associations with feeding habits in domesticated mandarin fish by scanning their complete genomic sequence. In total, two SNPs were found in PEP, one was found in TRY, and none were found in AMY. The D1(CTCC and D5(TTTT diplotypes in the PEP gene tended to show strong effects on the feeding habits of domesticated fish (p < 0.01. The results indicate that PEP may be associated with the genetic mechanism for feeding habits in mandarin fish, and the D1(CTCC and D5(TTTT diplotypes in the PEP gene may be useful markers for selecting mandarin fish with appropriate feeding habits for domestication.

  3. Effects of polymorphisms in pepsinogen (PEP), amylase (AMY) and trypsin (TRY) genes on food habit domestication traits in mandarin fish.

    Science.gov (United States)

    Yi, Tilin; Sun, Jian; Liang, Xufang; He, Shan; Li, Ling; Wen, Zhengyong; Shen, Dan

    2013-10-30

    Mandarin fish (Siniperca chuatsi) have a peculiar feeding habit of only accepting live fish prey and refusing dead prey and artificial diets. However, previous research has shown that some individuals accept dead prey after gradual domestication. Digestive enzymes are correlated with feeding habits in fish. In the current study, SNPs in the mandarin fish genes for pepsinogen (PEP), amylase (AMY), and trypsin (TRY) were evaluated for associations with feeding habits in domesticated mandarin fish by scanning their complete genomic sequence. In total, two SNPs were found in PEP, one was found in TRY, and none were found in AMY. The D1(CTCC) and D5(TTTT) diplotypes in the PEP gene tended to show strong effects on the feeding habits of domesticated fish (p < 0.01). The results indicate that PEP may be associated with the genetic mechanism for feeding habits in mandarin fish, and the D1(CTCC) and D5(TTTT) diplotypes in the PEP gene may be useful markers for selecting mandarin fish with appropriate feeding habits for domestication.

  4. AMiBA: Sunyaev-Zel'dovich effect derived properties and scaling relations of massive galaxy clusters

    CERN Document Server

    Ho, Paul T P; Liu, Guo-Chin; Molnar, Sandor M; Nishioka, Hiroaki; Umetsu, Keiichi; Altamirano, Pablo; Birkinshaw, Mark; Chang, Chia-Hao; Chang, Shu-Hao; Chang, Su-Wei; Chen, Ming-Tang; Han, Chih-Chiang; Huang, Yau-De; Hwang, Yuh-Jing; Jiang, Homin; Kesteven, Michael; Kubo, Derek; Li, Chao-Te; Martin-Cocher, Pierre; Oshiro, Peter; Raffin, Philippe; Wei, Tashun; Wilson, Warwick

    2010-01-01

    The Sunyaev-Zel'dovich Effect (SZE) has been observed toward six massive galaxy clusters, at redshifts 0.091 \\leq z \\leq 0.322 in the 86-102 GHz band with the Y. T. Lee Array for Microwave Background Anisotropy (AMiBA). We modify an iterative method, based on the isothermal \\beta-models, to derive the electron temperature T_e, total mass M_t, gas mass M_g, and integrated Compton Y within r_2500, from the AMiBA SZE data. Non-isothermal universal temperature profile (UTP) \\beta models are also considered in this paper. These results are in good agreement with those deduced from other observations. We also investigate the embedded scaling relations, due to the assumptions that have been made in the method we adopted, between these purely SZE-deduced T_e, M_t, M_g and Y. Our results suggest that cluster properties may be measurable with SZE observations alone. However, the assumptions built into the pure-SZE method bias the results of scaling relation estimations and need further study.

  5. AMiBA: scaling relations between the integrated Compton-y and X-ray derived temperature, mass, and luminosity

    CERN Document Server

    Ho, Paul T P; Liu, Guo-Chin; Molnar, Sandor M; Nishioka, Hiroaki; Umetsu, Keiichi; Altamirano, Pablo; Birkinshaw, Mark; Chang, Chia-Hao; Chang, Shu-Hao; Chang, Su-Wei; Chen, Ming-Tang; Han, Chih-Chiang; Huang, Yau-De; Hwang, Yuh-Jing; Jiang, Homin; Kesteven, Michael; Kubo, Derek; Li, Chao-Te; Martin-Cocher, Pierre; Oshiro, Peter; Raffin, Philippe; Wei, Tashun; Wilson, Warwick

    2009-01-01

    We investigate the scaling relations between the X-ray and the thermal Sunyaev-Zel'dovich Effect (SZE) properties of clusters of galaxies, using data taken during 2007 by the Y.T. Lee Array for Microwave Background Anisotropy (AMiBA) at 94 GHz for the six clusters A1689, A1995, A2142, A2163, A2261, and A2390. The scaling relations relate the integrated Compton-y parameter Y_{2500} to the X-ray derived gas temperature T_{e}, total mass M_{2500}, and bolometric luminosity L_X within r_{2500}. Our results for the power-law index and normalization are both consistent with the self-similar model and other studies in the literature except for the Y_{2500}-L_X relation, for which a physical explanation is given though further investigation may be still needed. Our results not only provide confidence for the AMiBA project but also support our understanding of galaxy clusters.

  6. FTT-MA: A Flexible Time-Triggered Middleware Architecture for Time Sensitive, Resource-Aware AmI Systems

    Directory of Open Access Journals (Sweden)

    Federico Pérez

    2013-05-01

    Full Text Available There is an increasing number of Ambient Intelligence (AmI systems that are time-sensitive and resource-aware. From healthcare to building and even home/office automation, it is now common to find systems combining interactive and sensing multimedia traffic with relatively simple sensors and actuators (door locks, presence detectors, RFIDs, HVAC, information panels, etc.. Many of these are today known as Cyber-Physical Systems (CPS. Quite frequently, these systems must be capable of (1 prioritizing different traffic flows (process data, alarms, non-critical data, etc., (2 synchronizing actions in several distributed devices and, to certain degree, (3 easing resource management (e.g., detecting faulty nodes, managing battery levels, handling overloads, etc.. This work presents FTT-MA, a high-level middleware architecture aimed at easing the design, deployment and operation of such AmI systems. FTT-MA ensures that both functional and non-functional aspects of the applications are met even during reconfiguration stages. The paper also proposes a methodology, together with a design tool, to create this kind of systems. Finally, a sample case study is presented that illustrates the use of the middleware and the methodology proposed in the paper.

  7. Prevention of AMI Induced Ventricular Remodeling: Inhibitory Effects of Heart-Protecting Musk Pill on IL-6 and TNF-Alpha

    Science.gov (United States)

    Chen, Zhiliang; Hoppe, Ralph

    2017-01-01

    Heart-Protecting Musk Pill (HMP) is a Traditional Chinese Medicine (TCM) that has been used for the prevention and treatment of coronary heart disease in clinic. The current study investigated the effect of HMP on the concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) and observed the relationship between level changes of inflammatory cytokines and ventricular remodeling in rats with acute myocardial infarction (AMI). Animal models of AMI were made by coronary artery ligation in Sprague-Dawley (SD) rats. AMI rats showed increased levels of IL-6 and TNF-α. Treatment with HMP decreases IL-6 and TNF-α concentrations in rats with AMI. Histopathological and transmission electron microscopic findings were also essentially in agreement with biochemical findings. The results of our study revealed that inflammatory cytokines IL-6 and TNF-α induce cardiac remodeling in rats after AMI; HMP improves cardiac function and ameliorates ventricular remodeling by downregulating the expression of IL-6 and TNF-α and further suppressing the ultrastructural changes of myocardial cells. PMID:28373886

  8. Asteroid Moon Micro-imager Experiment (amie) For Smart-1 Mission, Science Objectives and Devel- Opment Status.

    Science.gov (United States)

    Josset, J.-L.; Heather, D.; Dunkin, S.; Roussel, F.; Beauvivre, S.; Kraenhenbuehl, D.; Plancke, P.; Lange-Vin, Y.; Pinet, P.; Chevrel, S.; Cerroni, P.; de Sanctis, M.-C.; Dillelis, A.; Sodnik, Z.; Koschny, D.; Barucci, A.; Hofmann, B.; Josset, M.; Muinonen, K.; Pironnen, J.; Ehrenfreud, P.; Shkuratov, Y.; Shevchenko, V.

    The Asteroid Moon micro-Imager Experiment (AMIE), which will be on board the first ESA SMART-1 mission to the Moon (launch foreseen late 2002), is an imaging sys- tem with scientific, technical and public outreach oriented objectives. The science objectives are to imagine the Lunar South Pole (Aitken basin), permanent shadow areas (ice deposit), eternal light (crater rims), ancient Lunar Non- mare volcanism, local spectro-photometry and physical state of the lunar surface, and to map high latitudes regions (south) mainly at far side (Fig. 1). The technical objectives are to perform a laser-link experiment (detection of laser beam emitted by ESA Tenerife ground station), flight demonstration of new technologies, navigation aid (feasi- bility study), and on-board autonomy investigations. Figure 3: AMIE camera ( 100m) and a mirror to image downwards. The samples used were anorthosite from northern Finland, basalt from Antarctis, meteorites and other lunar analog materials. A spectralon panel has also been used to have flat fields references. The samples were imaged with dif- Figure 1: SMART-1 camera imaging the Moon (simulated view) ferent phase angles. Figure 4 shows images obtained with In order to have spectral information of the surface of the basalt and olivine samples, with different integration times Moon, the camera is equipped with a set of filters (Fig. 2), in order to have information in all areas. introduced between the CCD and the teleobjective. Bandpass-filter No Filter, 750 nm (1) AR coating (3) Bandpass-filter 915 nm (2) Longpass-filter 960 nm (4) Band- Band- Figure 4: Basalt and Olivine sample ­ entire image (left) and passfilter passfilter 915 nm 750 nm visible part () (6) (7) Bandpass- More than 150 images were acquired during this validation filter 847 nm (5) campaign and analysis of this data will give precious in- formation about the instrument ability to image the south Figure 2: AMIE Filters in front of the detector pole of our satellite, with

  9. AMIE (ARM MJO Investigation Experiment): Observations of the Madden-Julian Oscillation for Modeling Studies Science Plan

    Energy Technology Data Exchange (ETDEWEB)

    Long, C; Del Genio, A; Gustafson, W; Houze, R; Jakob, C; Jensen, M; Klein, S; Leung, L Ruby; Liu, X; Luke, E; May, P; McFarlane, S; Minnis, P; Schumacher, C; Vogelmann, A; Wang, Y; Wu, X; Xie, S

    2010-03-22

    Deep convection in the tropics plays an important role in driving global circulations and the transport of energy from the tropics to the mid-latitudes. Understanding the mechanisms that control tropical convection is a key to improving climate modeling simulations of the global energy balance. One of the dominant sources of tropical convective variability is the Madden-Julian Oscillation (MJO), which has a period of approximately 30–60 days. There is no agreed-upon explanation for the underlying physics that maintain the MJO. Many climate models do not show well-defined MJO signals, and those that do have problems accurately simulating the amplitude, propagation speed, and/or seasonality of the MJO signal. Therefore, the MJO is a very important modeling target for the ARM modeling community geared specifically toward improving climate models. The ARM MJO Investigation Experiment (AMIE) period coincides with a large international MJO initiation field campaign called CINDY2011 (Cooperative Indian Ocean experiment on intraseasonal variability in the Year 2011) that will take place in and around the Indian Ocean from October 2011 to January 2012. AMIE, in conjunction with CINDY2011 efforts, will provide an unprecedented data set that will allow investigation of the evolution of convection within the framework of the MJO. AMIE observations will also complement the long-term MJO statistics produced using ARM Manus data and will allow testing of several of the current hypotheses related to the MJO phenomenon. Taking advantage of the expected deployment of a C-POL scanning precipitation radar and an ECOR surface flux tower at the ARM Manus site, we propose to increase the number of sonde launches to eight per day starting in about mid-October of the field experiment year, which is climatologically a period of generally suppressed conditions at Manus and just prior to the climatologically strongest MJO period. The field experiment will last until the end of the MJO

  10. The effect of acute Lithium and AMI-193, a new 5HT2 antagonist, on Apomorphine-induced pecking in pigeon

    OpenAIRE

    Bagheri T; Ejtemaei Mehr Sh; Shamshirgaran Sh

    2002-01-01

    Intramascular (IM) administration of apomorphine (a mixed D1/D2 dopamine receptors agonist 0.2-1.6 mg/kg) induced pecking, a stereotype behavior in pigeons in a dose- dependent manner. In this study the effect of lithium (Li+, 240 mg/kg, IM) and AMI-193 (a new 5-HT2 antagonist, 0.003 mg/pigeon) on apomorphine-induced peking (AIP) were investigated. This study showed that Li+ and AMI-193 did not induce pecking by itself but administration of each of these agents before apomorphine increased an...

  11. The loss of a large DNA fragment is associated with an aerial mycelium negative (Amy-) phenotype of Streptomyces cattleya.

    Science.gov (United States)

    Usdin, K; Christians, K M; de Wet, C A; Potgieter, T D; Shaw, C B; Kirby, R

    1985-04-01

    Hybridization of various Streptomyces cattleya aerial mycelium negative (Amy-) mutants with a probe containing the gene for argininosuccinate synthetase (pTG17) has revealed the presence of two different types of mutants (stable and unstable). Stable mutants appear to have lost all or part of the region covered by the probe, while the unstable mutants demonstrate no detectable changes in this region. In one group of stable mutants (those demonstrating a partial loss of sequences hybridizing to the probe), a 4.17 kb extrachromosomal element was detected, which hybridized with the pTG17 probe. The significance of this finding is discussed with reference to the genetic instability of the genus Streptomyces.

  12. Studierende, Google, die Welt der Bibliotheken und deren kulturelle Bedeutung. Ein Essay zu einem Aufsatz von Amy Bruckman

    Directory of Open Access Journals (Sweden)

    Thomas Hapke

    2006-04-01

    Full Text Available Amy S. Bruckman skizziert in ihrem Artikel „Student research and the internet“ die Welt der Information für Studierende und weist auf die Notwendigkeit einer ernsthaften Reflexion über Information sowie die erkenntnistheoretische Problematik der Bewertung und Gültigkeit von Wissen und damit über die soziale Konstruktion von Wissen und Wissenschaft hin. Informationskompetenz umfasst – mehr als Recherchekompetenz – vor allem Kreativität, den eigenen Informationsprozess bewusst und bedarfsgerecht zu gestalten. In einem Exkurs werden Aktivitäten der Suchmaschine Google hinsichtlich ihrer Bedeutung für den Informationsprozess beleuchtet und der bleibende kulturelle Einfluss von Bibliotheken betont. Über Informationskompetenz hinaus sollten wissenschaftstheoretische und wissenschaftsgeschichtliche Aspekte von Wissenschaft aber auch Methoden und Techniken wissenschaftlichen Arbeitens verpflichtender Teil jedes Studiums sein. Ein Teil, der durchaus auch zur Informationskompetenz-Förderung durch Bibliotheken gehören kann.

  13. Module 1,Unit 1 Amy is taller than Lingling(《新标准英语》Book 8)

    Institute of Scientific and Technical Information of China (English)

    黎娜; 郑文

    2005-01-01

    一、案例背景1.教学内容本节课教学内容是形容词比较级的用法,所涉及的语言功能是进行两者之间的比较,所运用的主要语言结构是:Amy is taller thanLingling./Amy’s foot is longer than Lin-gling’s./Which one is shorter?本模块拟用三课时完成,本节课是第一课时。通过本课时的学习,学生应能初步运用"...is...than..."句型对两件事物进行比较。2.教学目标(1)知识目标:掌握形容词的比较级:

  14. Betwixt and Between Past and Present: Cultural and Generic Hybridity in the Fiction of Amy Tan and Mary Yukari Waters

    Directory of Open Access Journals (Sweden)

    Rania Youssef

    2013-10-01

    Full Text Available Amy Tan and Mary Yukari Waters are both Asian-Americans who portray hybridity in their short stories which depict the shifting identities of the self. But do the internal categories of gender, race and ethnicity help in the coherence or do they add to the fragmentation of diverse identities? It is the dynamics of this critique of multiple identification and hybrid cultures that is being traced here in this study and how all this is reflected in narrative responses to such conditions of the examination of the self and, on a broader scale, community. The study builds on Victor Turner’s theory of liminality. Key words Hybridity, liminality, multiple identity, race, culture.

  15. Cardio-eigenoscopy: significance of this new method in prognosis of risks of fatal arrhythmia progression in AMI patients

    Directory of Open Access Journals (Sweden)

    Dmitry V. Issakevich

    2013-05-01

    Full Text Available The aim of the study was to evaluate the significance of cardioeigenoscopy method for the prognosis of risks of fatal arrhythmia (the primary and secondary VF progression in AMI individuals.The study was performed with the use of the PC-assisted hemodynamic analyzer Cardiocode. The cardio-eigenoscopy was developed as a methodology that is capable of presenting all ECG changes in the basis of eigenvectors of a covariance matrix of ECG amplitudes and providing an analysis of a spectrum of eigenvalues. The ECG analysis software is implemented as a real-time monitoring of a set of parameters that makes possible to evaluate the therapy effectiveness. The cardio-eigenoscopy method is capable of assessing the risk of progression of fatal arrhythmia events in MI patients. The major markers of the possible progression of fatal arrhythmia were identified. The cardioeigenoscopy provided the maximum expressibility of an ECG curve at any specified EVE values.

  16. On the Equality Assumption of Latent and Sensible Heat Energy Transfer Coefficients of the Bowen Ratio Theory for Evapotranspiration Estimations: Another Look at the Potential Causes of Inequalities

    Directory of Open Access Journals (Sweden)

    Suat Irmak

    2014-08-01

    Full Text Available Evapotranspiration (ET and sensible heat (H flux play a critical role in climate change; micrometeorology; atmospheric investigations; and related studies. They are two of the driving variables in climate impact(s and hydrologic balance dynamics. Therefore, their accurate estimate is important for more robust modeling of the aforementioned relationships. The Bowen ratio energy balance method of estimating ET and H diffusions depends on the assumption that the diffusivities of latent heat (KV and sensible heat (KH are always equal. This assumption is re-visited and analyzed for a subsurface drip-irrigated field in south central Nebraska. The inequality dynamics for subsurface drip-irrigated conditions have not been studied. Potential causes that lead KV to differ from KH and a rectification procedure for the errors introduced by the inequalities were investigated. Actual ET; H; and other surface energy flux parameters using an eddy covariance system and a Bowen Ratio Energy Balance System (located side by side on an hourly basis were measured continuously for two consecutive years for a non-stressed and subsurface drip-irrigated maize canopy. Most of the differences between KV and KH appeared towards the higher values of KV and KH. Although it was observed that KV was predominantly higher than KH; there were considerable data points showing the opposite. In general; daily KV ranges from about 0.1 m2∙s−1 to 1.6 m2∙s−1; and KH ranges from about 0.05 m2∙s−1 to 1.1 m2∙s−1. The higher values for KV and KH appear around March and April; and around September and October. The lower values appear around mid to late December and around late June to early July. Hourly estimates of KV range between approximately 0 m2∙s−1 to 1.8 m2∙s−1 and that of KH ranges approximately between 0 m2∙s−1 to 1.7 m2∙s−1. The inequalities between KV and KH varied diurnally as well as seasonally. The inequalities were greater during the non

  17. Characterization of the starch-acting MaAmyB enzyme from Microbacterium aurum B8.A representing the novel subfamily GH13_42 with an unusual, multi-domain organization

    NARCIS (Netherlands)

    Valk, Vincent; van der Kaaij, Rachel M; Dijkhuizen, Lubbert

    2016-01-01

    The bacterium Microbacterium aurum strain B8.A degrades granular starches, using the multi-domain MaAmyA α-amylase to initiate granule degradation through pore formation. This paper reports the characterization of the M. aurum B8.A MaAmyB enzyme, a second starch-acting enzyme with multiple FNIII and

  18. Rock and roll or rock and fall? Gendered framing of the rock and roll lifestyles of Amy Winehouse and Pete Doherty in British broadsheets

    NARCIS (Netherlands)

    P.P.L. Berkers (Pauwke); M. Eeckelaer (Merel)

    2014-01-01

    textabstractCombining insights from gender, popular music, and celebrity studies, this article addresses to what extent British broadsheets frame Amy Winehouse and Pete Doherty differently with regard to their rock and roll lifestyle. Our content analyses of The Guardian and The Independent indicate

  19. Rock and roll or rock and fall? Gendered framing of the rock and roll lifestyles of Amy Winehouse and Pete Doherty in British broadsheets

    NARCIS (Netherlands)

    P.P.L. Berkers (Pauwke); M. Eeckelaer (Merel)

    2014-01-01

    textabstractCombining insights from gender, popular music, and celebrity studies, this article addresses to what extent British broadsheets frame Amy Winehouse and Pete Doherty differently with regard to their rock and roll lifestyle. Our content analyses of The Guardian and The Independent indicate

  20. One-year results of the randomized, controlled, short-term psychotherapy in acute myocardial infarction (STEP-IN-AMI) trial

    NARCIS (Netherlands)

    Roncella, Adriana; Pristipino, Christian; Cianfrocca, Cinzia; Scorza, Silvia; Pasceri, Vincenzo; Pelliccia, Francesco; Denollet, J.; Pedersen, S.S.; Speciale, Giulio

    2013-01-01

    BACKGROUND: Previous studies on cognitive and interpersonal interventions have yielded inconsistent results in ischemic heart disease patients. METHODS: 101 patients aged ≤ 70 years, and enrolled one week after complete revascularization with urgent/emergent angioplasty for an AMI, were randomized t

  1. Balanço de energia e estimativa da evapotranspiração em culturas irrigadas de maracujazeiro pelo método da razão de Bowen Energy balance and estimative of the evapotranspiration of irrigated passionfruit crops by the Bowen ratio method

    Directory of Open Access Journals (Sweden)

    Tonny J. A. Silva

    2007-08-01

    Full Text Available A cultura do maracujazeiro-amarelo tem tido grande expansão da área cultivada no Estado de São Paulo e, apesar da importância da irrigação para a cultura, há poucos estudos sobre sua utilização. Este trabalho foi realizado na área experimental de irrigação, na Fazenda Areão, do Departamento de Engenharia Rural, da Escola Superior de Agricultura "Luiz de Queiroz" - ESALQ/USP (Piracicaba - SP. Foram coletados dados de saldo de radiação, fluxo de calor no solo, gradientes de temperatura e pressão de vapor do ar com o objetivo de avaliar a partição da energia disponível e a evapotranspiração em cultivo de maracujazeiros em dois sistemas de plantio (linhas de cultivo norte-sul e leste-oeste. O método da razão de Bowen foi utilizado na determinação dos fluxos de calor sensível e latente. O saldo de radiação não foi influenciado pelo sistema de plantio, sendo equivalente a 60% da radiação global. O componente de maior contribuição no balanço de energia foi o calor latente de evaporação ocorrendo imediatamente após a chuva ou irrigação. A utilização do modelo de análise e exclusão de intervalos em que o método da Razão de Bowen falha, melhora a estimativa da evapotranspiração.Passionfruit crop has been having great expansion in the cultivated area of São Paulo State and beside the irrigation importance for crop; there are few studies about its utilization. This work was carried out at the experimental irrigation farm of the Engineering Department - College of Agriculture "Luiz de Queiroz" - ESALQ/USP, in Piracicaba, São Paulo State, Brazil. Were collected micrometeorological data from net radiation, soil flux heat, temperature and vapor pressure gradient with the aim to evaluate the partition of available energy and evapotranspiration of passionfruit crop planted under two row directions (North-South and East-West. The Bowen ratio method was used to determine both sensible and latent fluxes. The net

  2. Comparison of eddy covariance and modified Bowen ratio methods for measuring gas fluxes and implications for measuring fluxes of persistent organic pollutants

    Science.gov (United States)

    Bolinius, Damien Johann; Jahnke, Annika; MacLeod, Matthew

    2016-04-01

    Semi-volatile persistent organic pollutants (POPs) cycle between the atmosphere and terrestrial surfaces; however measuring fluxes of POPs between the atmosphere and other media is challenging. Sampling times of hours to days are required to accurately measure trace concentrations of POPs in the atmosphere, which rules out the use of eddy covariance techniques that are used to measure gas fluxes of major air pollutants. An alternative, the modified Bowen ratio (MBR) method, has been used instead. In this study we used data from FLUXNET for CO2 and water vapor (H2O) to compare fluxes measured by eddy covariance to fluxes measured with the MBR method using vertical concentration gradients in air derived from averaged data that simulate the long sampling times typically required to measure POPs. When concentration gradients are strong and fluxes are unidirectional, the MBR method and the eddy covariance method agree within a factor of 3 for CO2, and within a factor of 10 for H2O. To remain within the range of applicability of the MBR method, field studies should be carried out under conditions such that the direction of net flux does not change during the sampling period. If that condition is met, then the performance of the MBR method is neither strongly affected by the length of sample duration nor the use of a fixed value for the transfer coefficient.

  3. Growth arrest in the ribosomopathy, Bowen-Conradi syndrome, is due to dramatically reduced cell proliferation and a defect in mitotic progression.

    Science.gov (United States)

    Armistead, Joy; Patel, Nehal; Wu, Xiaoli; Hemming, Richard; Chowdhury, Biswajit; Basra, Gagandeep Singh; Del Bigio, Marc R; Ding, Hao; Triggs-Raine, Barbara

    2015-05-01

    Bowen-Conradi syndrome (BCS) is a ribosomopathy characterized by severe developmental delay and growth failure that typically leads to death by one year of age. It is caused by a c.257A>G, p.D86G substitution in the ribosomal biogenesis protein, Essential for Mitotic Growth 1 (EMG1). We generated a knock-in of the D86G substitution in mice to characterize the effects of EMG1 deficiency, particularly in the brain, where EMG1 expression is high. Embryos homozygous for the mutation in Emg1 were small for gestational age with neural tube defects, and died between embryonic days 8.5 and 12.5. These embryos exhibited dramatically reduced cell proliferation, which we also detected in autopsy brain tissue and bone marrow of BCS patients, consistent with a requirement for high levels of EMG1 in tissues with rapid cell proliferation. In fibroblasts derived from the BCS mouse embryos, we detected a high proportion of binucleated cells, indicating that a mitotic defect underlies the growth arrest in BCS. These studies add to growing evidence of a link between ribosome biogenesis, mitotic progression, and brain development that is currently unexplored.

  4. Comparison of eddy covariance and modified Bowen ratio methods for measuring gas fluxes and implications for measuring fluxes of persistent organic pollutants

    Directory of Open Access Journals (Sweden)

    D. J. Bolinius

    2015-11-01

    Full Text Available Semi-volatile persistent organic pollutants (POPs cycle between the atmosphere and terrestrial surfaces, however measuring fluxes of POPs between the atmosphere and other media is challenging. Sampling times of hours to days are required to accurately measure trace concentrations of POPs in the atmosphere, which rules out the use of eddy covariance techniques that are used to measure gas fluxes of major air pollutants. An alternative, the modified Bowen ratio (MBR method, has been used instead. In this study we used data from FLUXNET for CO2 and water vapor (H2O to compare fluxes measured by eddy covariance to fluxes measured with the MBR method using vertical concentration gradients in air derived from averaged data that simulates the long sampling times typically required to measure POPs. When concentration gradients are strong and fluxes are unidirectional, the MBR method and the eddy covariance method agree within a factor of 3 for CO2, and within a factor of 10 for H2O. To remain within the range of applicability of the MBR method field, studies should be carried out under conditions such that the direction of net flux does not change during the sampling period. If that condition is met then the performance of the MBR method is not strongly affected by the length of sample duration nor the use of a fixed value for the transfer coefficient.

  5. The Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) Classification System: A Taxonomy for Young Women With Acute Myocardial Infarction.

    Science.gov (United States)

    Spatz, Erica S; Curry, Leslie A; Masoudi, Frederick A; Zhou, Shengfan; Strait, Kelly M; Gross, Cary P; Curtis, Jeptha P; Lansky, Alexandra J; Soares Barreto-Filho, Jose Augusto; Lampropulos, Julianna F; Bueno, Hector; Chaudhry, Sarwat I; D'Onofrio, Gail; Safdar, Basmah; Dreyer, Rachel P; Murugiah, Karthik; Spertus, John A; Krumholz, Harlan M

    2015-11-03

    Current classification schemes for acute myocardial infarction (AMI) may not accommodate the breadth of clinical phenotypes in young women. We developed a novel taxonomy among young adults (≤55 years) with AMI enrolled in the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) study. We first classified a subset of patients (n=600) according to the Third Universal Definition of MI using a structured abstraction tool. There was heterogeneity within type 2 AMI, and 54 patients (9%; including 51 of 412 women) were unclassified. Using an inductive approach, we iteratively grouped patients with shared clinical characteristics, with the aims of developing a more inclusive taxonomy that could distinguish unique clinical phenotypes. The final VIRGO taxonomy classified 2802 study participants as follows: class 1, plaque-mediated culprit lesion (82.5% of women; 94.9% of men); class 2, obstructive coronary artery disease with supply-demand mismatch (2a: 1.4% women; 0.9% men) and without supply-demand mismatch (2b: 2.4% women; 1.1% men); class 3, nonobstructive coronary artery disease with supply-demand mismatch (3a: 4.3% women; 0.8% men) and without supply-demand mismatch (3b: 7.0% women; 1.9% men); class 4, other identifiable mechanism (spontaneous dissection, vasospasm, embolism; 1.5% women, 0.2% men); and class 5, undetermined classification (0.8% women, 0.2% men). Approximately 1 in 8 young women with AMI is unclassified by the Universal Definition of MI. We propose a more inclusive taxonomy that could serve as a framework for understanding biological disease mechanisms, therapeutic efficacy, and prognosis in this population. © 2015 American Heart Association, Inc.

  6. Impact of Percutaneous Coronary Intervention for Chronic Total Occlusion in Non-Infarct-Related Arteries in Patients With Acute Myocardial Infarction (from the COREA-AMI Registry).

    Science.gov (United States)

    Choi, Ik Jun; Koh, Yoon-Seok; Lim, Sungmin; Choo, Eun Ho; Kim, Jin Jin; Hwang, Byung-Hee; Kim, Tae-Hoon; Seo, Suk Min; Kim, Chan Joon; Park, Mahn-Won; Shin, Dong Il; Choi, Yun-Seok; Park, Hun-Jun; Her, Sung-Ho; Kim, Dong-Bin; Park, Chul Soo; Lee, Jong-Min; Moon, Keon Woong; Chang, Kiyuk; Kim, Hee Yeol; Yoo, Ki-Dong; Jeon, Doo Soo; Chung, Wook-Sung; Ahn, Youngkeun; Jeong, Myung Ho; Seung, Ki-Bae; Kim, Pum-Joon

    2016-04-01

    Chronic total occlusion (CTO) in a non-infarct-related artery (IRA) is an independent predictor of clinical outcomes in patients with acute myocardial infarction (AMI). This study evaluated the impact of successful percutaneous coronary intervention (PCI) for CTO of a non-IRA on the long-term clinical outcomes in patients with AMI. A total of 4,748 patients with AMI were consecutively enrolled in the Convergent Registry of Catholic and Chonnam University for AMI registry from January 2004 to December 2009. We enrolled 324 patients with CTO in a non-IRA. To adjust for baseline differences, propensity matching (96 matched pairs) was used to compare successful PCI and occluded CTO for the treatment of CTO in non-IRA. The primary clinical end points were all-cause mortality and a composite of the major adverse cardiac events, including cardiac death, MI, stroke, and any revascularization during the 5-year follow-up. Patients who received successful PCI for CTO of non-IRA had lower rates of all-cause mortality (16.7% vs 32.3%, hazard ratio 0.459, 95% CI 0.251 to 0.841, p = 0.012) and major adverse cardiac events (21.9% vs 55.2%, hazard ratio 0.311, 95% CI 0.187 to 0.516, p <0.001) compared with occluded CTO group. Subgroup analyses revealed that successful PCI resulted in a better mortality rate in patients with normal renal function compared to patients with chronic kidney disease (p = 0.010). In conclusion, successful PCI for CTO of non-IRA is associated with improved long-term clinical outcomes in patients with AMI.

  7. Purification, characterization, and partial primary sequence of a major-maltotriose-producing alpha-amylase, ScAmy43, from Sclerotinia sclerotiorum.

    Science.gov (United States)

    Ben Abdelmalek-Khedher, Imen; Urdaci, Maria Camino; Limam, Ferid; Schmitter, Jean Marie; Marzouki, M Nejib; Bressollier, Philippe

    2008-09-01

    A novel alpha-amylase (alpha-1,4-alpha-D-glucan glucanohydrolase, E.C. 3.2.1.1), ScAmy43, was found in the culture medium of the phytopathogenic fungus Sclerotinia sclerotiorum grown on oats flour. Purified to homogeneity, ScAmy43 appeared as a 43 kDa monomeric enzyme, as estimated by SDS-PAGE and Superdex 75 gel filtration. The MALDI peptide mass fingerprint of ScAmy43 tryptic digest as well as internal sequence analyses indicate that the enzyme has an original primary structure when compared with other fungal alpha- amylases. However, the sequence of the 12 N-terminal residues is homologous with those of Aspergillus awamori and Aspergillus kawachii amylases, suggesting that the new enzyme belongs to the same GH13 glycosyl hydrolase family. Assayed with soluble starch as substrate, this enzyme displayed optimal activity at pH 4 and 55oC with an apparent Km value of 1.66 mg/ml and Vmax of 0.1 micromol glucose x min-1 x ml-1. ScAmy43 activity was strongly inhibited by Cu2+, Mn2+, and Ba2+, moderately by Fe2+, and was only weakly affected by Ca2+ addition. However, since EDTA and EGTA did not inhibit ScAmy43 activity, this enzyme is probably not a metalloprotein. DTT and beta-mercaptoethanol strongly increased the enzyme activity. Starting with soluble starch as substrate, the end products were mainly maltotriose, suggesting for this enzyme an endo action.

  8. «Il nastro a rovescio». Possibili influenze di Storie Naturali ne La freccia del tempo di Martin Amis

    Directory of Open Access Journals (Sweden)

    Giuseppe Alvino

    2016-11-01

    Full Text Available Il presente contributo si propone di ripercorrere le tappe del rapporto letterario tra Martin Amis e Primo Levi, sottolineando l’attenzione dello scrittore inglese nei confronti dei testi di Levi. Come Amis stesso scrive più volte, Levi fu per lui una delle letture fondamentali nel suo percorso di ricerca letteraria; e nella Postfazione di una delle sue opere principali, Time’s arrow (La freccia del tempo, l’autore richiama per ben due volte l’attenzione su Levi, da un lato, ritenendo che senza le letture leviane non avrebbe potuto scrivere il suo romanzo, e dall’altro, avvertendo il lettore che il titolo pensato originariamente era un’espressione leviana, La natura dell’offesa (oggi secondo titolo de La freccia del tempo. Partendo da questi presupposti si nota come, nel racconto Trattamento di quiescenza della raccolta Storie Naturali, Levi parla tangenzialmente di uno scorrere del tempo al contrario e con una causalità inversa, nello stesso modo in cui Amis, in maniera più sistematica e precisa, costruisce per intero il suo romanzo. Dunque si potrebbe ipotizzare che Amis si sia ispirato non solo al Levi di Se questo è un uomo, La tregua e I sommersi e i salvati per il tema del suo romanzo (e cioè la barbarie nazista, ma anche al Levi dei racconti per il modo tutto particolare di narrare la sua storia. Del resto, la scelta di scrivere il romanzo ‘al contrario’ è funzionale al tema: solo in un mondo con un tempo e una causalità ‘al contrario’ la barbarie dei campi di concentramento sarebbe giustificabile. The purpose of this paper is to explore the literary relationship between Martin Amis and Primo Levi, highlighting how the English writer directed his attention to Levi’s works. As Amis himself often writes, Levi was one of his fundamental readings in his literary research; in the Afterword of one of his masterpieces, Time’s Arrow, the author mentions Levi twice: on the one hand, he claims that he could not

  9. Cloning,expression and characterization of α-amylase gene amy608 from deep-sea bacterium Flammeovirga pacifica%深海细菌太平洋火色杆菌中α-淀粉酶基因 amy608的克隆表达及其酶学性质研究

    Institute of Scientific and Technical Information of China (English)

    商谢谢; 蔡亚萍; 金敏; 曾润颖

    2016-01-01

    从来自深海沉积物的太平洋火色杆菌(Flammeovirga pacifica)的基因组中发现了一个全长为1875 bp 的α-淀粉酶基因 amy608.该基因在数据库中找不到具有同源性的序列,而所编码的Amy608蛋白与已注册蛋白的氨基酸序列相似性最高仅为56%,但具有α-淀粉酶水解活性所必需的保守基序 DXEXD.进化树分析表明其属于糖苷水解酶13(GH13)家族第二亚家族.构建了pColdΙ-amy608表达载体,在大肠杆菌中进行重组 Amy608蛋白的异源表达,并采用镍离子亲和层析柱对重组蛋白进行了纯化.酶学性质分析表明,重组酶 Amy608的最适作用温度为40℃,在40℃保温4 d 后,仍保留70%以上的酶活,显示出良好的中温热稳定性;最适 pH 值为7.0,pH 值范围在6~9时仍保留60%以上的酶活力,表明该酶具有较宽的 pH 值作用范围.Ca2+、Na +、K +对α-淀粉酶 Amy608有激活作用,尤其是 Ca2+可使酶活显著提高40%.薄层色谱分析结果显示该酶水解可溶性淀粉的最终产物以葡萄糖为主,表明该酶是一个糖化型淀粉水解内切酶.这些结果表明Amy608为 GH13家族第二亚家族中一个新型的α-淀粉酶.%A 1 875 bp α-amylase gene (designated as amy608)was identified from Flammeovirga pacific,which was isolated from deep-sea sediments.The DNA sequence of amy608 exhibited no significant similarity to those of any known genes.Amino acid sequence analysis showed that Amy608 possess a conserved DXEXD motif,which is essential for the hydrolysis activities of α-amylase.However,Amy608 shares only 56% maximum amino acid se-quence identity to other existing α-amylases.According to the phylogeny analytical results,Amy608 could be fur-ther classified into GH13 (glycoside hydrolase 13)subfamily-2.After heterologous expression in Escherichia coli, the recombinant Amy608 was purified with a Ni +affinity column.The recombinant enzyme was

  10. High external pH enables more efficient secretion of alkaline α-amylase AmyK38 by Bacillus subtilis

    Directory of Open Access Journals (Sweden)

    Manabe Kenji

    2012-06-01

    Full Text Available Abstract Background Bacillus subtilis genome-reduced strain MGB874 exhibits enhanced production of exogenous extracellular alkaline cellulase Egl-237 and subtilisin-like alkaline protease M-protease. Here, we investigated the suitability of strain MGB874 for the production of α-amylase, which was anticipated to provoke secretion stress responses involving the CssRS (Control secretion stress Regulator and Sensor system. Results Compared to wild-type strain 168, the production of a novel alkaline α-amylase, AmyK38, was severely decreased in strain MGB874 and higher secretion stress responses were also induced. Genetic analyses revealed that these phenomena were attributable to the decreased pH of growth medium as a result of the lowered expression of rocG, encoding glutamate dehydrogenase, whose activity leads to NH3 production. Notably, in both the genome-reduced and wild-type strains, an up-shift of the external pH by the addition of an alkaline solution improved AmyK38 production, which was associated with alleviation of the secretion stress response. These results suggest that the optimal external pH for the secretion of AmyK38 is higher than the typical external pH of growth medium used to culture B. subtilis. Under controlled pH conditions, the highest production level (1.08 g l-1 of AmyK38 was obtained using strain MGB874. Conclusions We demonstrated for the first time that RocG is an important factor for secretory enzyme production in B. subtilis through its role in preventing acidification of the growth medium. As expected, a higher external pH enabled a more efficient secretion of the alkaline α-amylase AmyK38 in B. subtilis. Under controlled pH conditions, the reduced-genome strain MGB874 was demonstrated to be a beneficial host for the production of AmyK38.

  11. Assessment of ionospheric Joule heating by GUMICS-4 MHD simulation, AMIE, and satellite-based statistics: towards a synthesis

    Directory of Open Access Journals (Sweden)

    M. Palmroth

    2005-09-01

    Full Text Available We investigate the Northern Hemisphere Joule heating from several observational and computational sources with the purpose of calibrating a previously identified functional dependence between solar wind parameters and ionospheric total energy consumption computed from a global magnetohydrodynamic (MHD simulation (Grand Unified Magnetosphere Ionosphere Coupling Simulation, GUMICS-4. In this paper, the calibration focuses on determining the amount and temporal characteristics of Northern Hemisphere Joule heating. Joule heating during a substorm is estimated from global observations, including electric fields provided by Super Dual Auroral Network (SuperDARN and Pedersen conductances given by the ultraviolet (UV and X-ray imagers on board the Polar satellite. Furthermore, Joule heating is assessed from several activity index proxies, large statistical surveys, assimilative data methods (AMIE, and the global MHD simulation GUMICS-4. We show that the temporal and spatial variation of the Joule heating computed from the GUMICS-4 simulation is consistent with observational and statistical methods. However, the different observational methods do not give a consistent estimate for the magnitude of the global Joule heating. We suggest that multiplying the GUMICS-4 total Joule heating by a factor of 10 approximates the observed Joule heating reasonably well. The lesser amount of Joule heating in GUMICS-4 is essentially caused by weaker Region 2 currents and polar cap potentials. We also show by theoretical arguments that multiplying independent measurements of averaged electric fields and Pedersen conductances yields an overestimation of Joule heating.

    Keywords. Ionosphere (Auroral ionosphere; Modeling and forecasting; Electric fields and currents

  12. α-淀粉酶基因amyP的原核表达及酶学性质分析

    Institute of Scientific and Technical Information of China (English)

    赵金海; 杨灵; 张志芳; 李轶女

    2014-01-01

    α-淀粉酶作为一种十分重要的酶制剂,目前工业上都是以微生物发酵法大规模生产的。从耐高温菌株Geobacillus. sp. POT5基因组中,用PCR的方法扩增得到该菌的α-淀粉酶基因,此基因被克隆,测序并在原核Escherichia coli表达系统中进行表达,并对该重组酶的酶学性质进行初步分析。%α-amylase is a very important enzyme,the mass production ofα-amylase is based on microorganism fermentation in the industry at present. The gene ofα-amylases(amyP)is amplified from the genome of the thermostable strain Geoba- cillus. sp. POT5 by PCR. This gene is cloned,Sequence analysis and expressed in procaryotic expression system in E.coli. This study also developes a preliminary analysis of enzyme properties about the recombinantα-amylase.

  13. AMI-LA radio continuum observations of Spitzer c2d small clouds and cores: Serpens region

    CERN Document Server

    Scaife, Anna M M; Ainsworth, Rachael E; Buckle, Jane V; Davies, Matthew; Franzen, Thomas M O; Grainge, Keith J B; Hobson, Michael P; Hurley-Walker, Natasha; Lasenby, Anthony N; Olamaie, Malak; Perrott, Yvette C; Pooley, Guy G; Richer, John S; Rodriguez-Gonzalvez, Carmen; Saunders, Richard D E; Schammel, Michel P; Scott, Paul F; Shimwell, Timothy; Titterington, David; Waldram, Elizabeth

    2011-01-01

    We present deep radio continuum observations of the cores identified as deeply embedded young stellar objects in the Serpens molecular cloud by the Spitzer c2d programme at a wavelength of 1.8cm with the Arcminute Microkelvin Imager Large Array (AMI-LA). These observations have a resolution of ~30arcsec and an average sensitivity of 19microJy/beam. The targets are predominantly Class I sources, and we find the detection rate for Class I objects in this sample to be low (18%) compared to that of Class 0 objects (67%), consistent with previous works. For detected objects we examine correlations of radio luminosity with bolometric luminosity and envelope mass and find that these data support correlations found by previous samples, but do not show any indiction of the evolutionary divide hinted at by similar data from the Perseus molecular cloud when comparing radio luminosity with envelope mass. We conclude that envelope mass provides a better indicator for radio luminosity than bolometric luminosity, based on t...

  14. Study of Ami Maka Ana ( Traditional Fermented Buffalo Milk as Nutritional Food at Los Palos East Timor

    Directory of Open Access Journals (Sweden)

    I Made Sugitha

    2014-01-01

    Full Text Available The study was conducted  to determine the public attitude toward the existence of traditional food ami maka-ana (AMAprepared by addition of maka wele( alip-bark in to buffalo milk at Locales. The method used were explorative and laboratory research, for determining the location was based on the method of purposive sampling, in which 4 villages  in the sub district of Locales was chosen as the location of the study. The samples of AMA were collected from each village which were tested organoleptically and chemical composition at  Food Nutrition Laboratory of FTP-Unud Denpasar, Bali, Indonesia.  The results showed that Panelists were like the taste and overall acceptance by its characteristics such as moisture ( 50.15%,  ash ( 2.00%, protein (18.15%, fat( 20.78%, lactose( 3.68%, total acidity( 0.86%,,  total solids ( 49.95% ,   total solids non fat ( 34.71%,  total count (5.65 x 104 CFU/g and lactic acid bacteria ( 2.15 x 104 CFU/g.

  15. Experimental study of fast and ultrafast T2-weighted imaging sequences using AMI-25 superparamagnetic iron oxide (SPIO.

    Directory of Open Access Journals (Sweden)

    Kurokawa H

    2001-02-01

    Full Text Available The objective of this study was to evaluate fast and ultrafast T2-weighted images (T2WI, including echo planar imaging (EPI, using an AMI-25 agar phantom. Image quality for conventional spin echo (CSE and turbo spin echo (TSE was almost equivalent. In high-resolution TSE, image quality was highest due to the use of a 512 x 256 matrix. Half-Fourier single-shot turbo SE (HASTE was associated with blurring of images, and turbo-gradient SE (TGSE showed a deterioration of image quality. EPI also suffered from poor image quality because this method is very sensitive to magnetic field inhomogeneity. CSE showed good signal-to-noise ratio (S/N and contrast ratio (CR, but also required the longest imaging times. Among the TSE sequences, TSE with a short echo train length (ETL was superior in terms of S/N. The CR of EPI and fast low angle shot (FLASH images were improved in proportion to the effective echo time (TE. At present, TSE is inferior to CSE in terms of S/N and CR. However, taking into consideration scanning time, TSE with a short ETL is thought to be suitable for routine examinations. Effective TE is an important factor in gradient echo (GRE examinations.

  16. Moist Process Biases in Simulations of the Madden–Julian Oscillation Episodes Observed during the AMIE/DYNAMO Field Campaign

    Energy Technology Data Exchange (ETDEWEB)

    Hagos, Samson M.; Feng, Zhe; Burleyson, Casey D.; Zhao, Chun; Martini, Matus N.; Berg, Larry K.

    2016-02-01

    Two Madden-Julian Oscillation (MJO) episodes observed during the 2011 AMIE/DYNAMO field campaign are simulated using a regional cloud-permitting model, a regional model with various cumulus parameterizations, and a global variable-resolution model with a high-resolution region centered over the tropical Indian Ocean. Model biases associated with moisture mode instability, wind-induced surface heat exchange (WISHE), and convective momentum transport (CMT) are examined and their relative contributions to the overall model errors are quantified using a linear statistical model. Linear relationships are found among the normalized root mean square errors of precipitation, saturation fraction, evaporation, and surface wind speed suggesting that errors may propagate across the processes involving these variables. Analysis using a linear statistical model shows the relationship between convection and local surface wind speed (related to CMT processes) is the source of the largest uncertainty. In comparison, WISHE processes in the simulations tend to be biased consistently, with excess evaporation for the same wind speeds as the observations, which suggests they are likely related to biases in boundary layer and/or surface schemes. The relationship between precipitation and saturation fraction (which is associated with moisture mode instability) is captured relatively well with slightly larger model precipitation in the simulations in comparison to observations for the same saturation fraction, especially for weak rain rates. By linking developments in theoretical understanding of MJO processes and cumulus parameterizations, this study provides guidance to future improvements of MJO simulation by in high-resolution regional and global models.

  17. Assessment of ionospheric Joule heating by GUMICS-4 MHD simulation, AMIE, and satellite-based statistics: towards a synthesis

    Science.gov (United States)

    Palmroth, M.; Janhunen, P.; Pulkkinen, T. I.; Aksnes, A.; Lu, G.; Østgaard, N.; Watermann, J.; Reeves, G. D.; Germany, G. A.

    2005-09-01

    We investigate the Northern Hemisphere Joule heating from several observational and computational sources with the purpose of calibrating a previously identified functional dependence between solar wind parameters and ionospheric total energy consumption computed from a global magnetohydrodynamic (MHD) simulation (Grand Unified Magnetosphere Ionosphere Coupling Simulation, GUMICS-4). In this paper, the calibration focuses on determining the amount and temporal characteristics of Northern Hemisphere Joule heating. Joule heating during a substorm is estimated from global observations, including electric fields provided by Super Dual Auroral Network (SuperDARN) and Pedersen conductances given by the ultraviolet (UV) and X-ray imagers on board the Polar satellite. Furthermore, Joule heating is assessed from several activity index proxies, large statistical surveys, assimilative data methods (AMIE), and the global MHD simulation GUMICS-4. We show that the temporal and spatial variation of the Joule heating computed from the GUMICS-4 simulation is consistent with observational and statistical methods. However, the different observational methods do not give a consistent estimate for the magnitude of the global Joule heating. We suggest that multiplying the GUMICS-4 total Joule heating by a factor of 10 approximates the observed Joule heating reasonably well. The lesser amount of Joule heating in GUMICS-4 is essentially caused by weaker Region 2 currents and polar cap potentials. We also show by theoretical arguments that multiplying independent measurements of averaged electric fields and Pedersen conductances yields an overestimation of Joule heating. Keywords. Ionosphere (Auroral ionosphere; Modeling and forecasting; Electric fields and currents)

  18. Purification, sequencing, and biochemical characterization of a novel calcium-independent α-amylase AmyTVE from Thermoactinomyces vulgaris.

    Science.gov (United States)

    El-Sayed, Ahmed K A; Abou Dobara, Mohamed I; El-Fallal, Amira A; Omar, Noha F

    2013-06-01

    α-Amylase from Thermoactinomyces vulgaris was highly purified 48.9-fold by ammonium sulfate precipitation, gel filtration on Sephadex G-50 column, and ion exchange chromatography column of DEAE-cellulose. The molecular weight of the enzyme was estimated to be 135 and 145 kDa by SDS-PAGE. Its high molecular weight is due to high glycosylation. The purified amylase exhibited maximal activity at pH 6.0 to 7.0 and was stable in the range of pH 4.0 to 9.0. The optimum temperature for its activity was 50 °C. The enzyme half-life time was 120 min at 50 °C, suggesting intermediate temperature stable α-amylase. The enzyme was sensitive to different metal ions, including NaCl, CoCl(2), and CaCl(2), and to different concentrations of EDTA. The enzyme activity was inhibited in the presence of 1 mM CaCl(2), suggesting that it is a calcium-independent α-amylase. The TLC showed that the amylase hydrolyzed starch to produce large maltooligosaccharides as the main products. A 1.1-kb DNA fragment of the putative α-amylase gene (amy TVE) from T. vulgaris was amplified by using two specific newly designed primers. Sequencing analysis showed 56.2 % similarity to other Thermoactinomyces α-amylases with two conserved active sites confirming its function.

  19. Short 5'-flanking regions of the Amy gene of Drosophila kikkawai affect amylase gene expression and respond to food environments.

    Science.gov (United States)

    Inomata, Nobuyuki; Nakashima, Shuichi

    2008-04-15

    Evolution of the duplicated genes and regulation in gene expression is of great interest, especially in terms of adaptation. Molecular population genetic and evolutionary studies on the duplicated amylase genes of Drosophila species have suggested that their 5'-flanking (cis-regulatory) regions play an important role in evolution of these genes. For better understanding of evolution of the duplicated amylase genes and gene expression, we studied functional significance of the Amy1 gene of Drosophila kikkawai using in vitro deletion mutagenesis followed by P-element-mediated germline transformation. We found that a 1.6-kb of the 5'-flanking region can produce strikingly higher level of larval amylase activity on starch food compared with that on glucose food. We found two cis-regulatory elements, which increase larval amylase activity on starch food. We also found a larval cis-regulatory element, which responds to the food difference. This food-response element is necessary for the function of the element increasing larval activity on starch food. A 5-bp deletion in a putative GRE caused high amylase activity, indicating a cis-regulatory element decreasing amylase activity. These cis-regulatory elements identified in the 5'-flanking region could be the targets of natural selection.

  20. The Politics of Transnational Memory in Amy Tan’s The Joy Luck Club

    Directory of Open Access Journals (Sweden)

    Silvia Schultermandl

    2011-12-01

    Full Text Available “The Politics of Transnational Memory in Amy Tan’s The Joy Luck Club” sees Tan’s representation of memory as either a function of loss (and limited recovery or of distance (whether temporal or physical. For Schultermandl, the text suggests that familial or national relationships built on generational and immigrant memory cannot really create conditions of solidarity or identification and are thus doomed to failure—either that, or what is “memory” must be transformed by “experience” and then be understood, what Schultermandl calls “belated memory.” Schultermandl offers an account of the failure of the narrative to provide for a bond between the generations of women—immigrant mothers and American-born daughters. This conceptual problem is represented by the novel’s end, where the overriding implication of the narrative is that in order to reconcile and occupy the identity of a Chinese American one must somehow be both Chinese and American, an experience of being that Schultermandl questions. Additionally, in not representing modern China or modern Chinese women, Schultermandl argues, the novel gives up an opportunity to create a “transnational solidarity” among women in favor of a national identity that supersedes the individual, who in Tan’s text becomes a mere stand-in for traditionally held ideological and national stereotypes.

  1. Characterization of the starch-acting MaAmyB enzyme from Microbacterium aurum B8.A representing the novel subfamily GH13_42 with an unusual, multi-domain organization

    Science.gov (United States)

    Valk, Vincent; van der Kaaij, Rachel M.; Dijkhuizen, Lubbert

    2016-01-01

    The bacterium Microbacterium aurum strain B8.A degrades granular starches, using the multi-domain MaAmyA α-amylase to initiate granule degradation through pore formation. This paper reports the characterization of the M. aurum B8.A MaAmyB enzyme, a second starch-acting enzyme with multiple FNIII and CBM25 domains. MaAmyB was characterized as an α-glucan 1,4-α-maltohexaosidase with the ability to subsequently hydrolyze maltohexaose to maltose through the release of glucose. MaAmyB also displays exo-activity with a double blocked PNPG7 substrate, releasing PNP. In M. aurum B8.A, MaAmyB may contribute to degradation of starch granules by rapidly hydrolyzing the helical and linear starch chains that become exposed after pore formation by MaAmyA. Bioinformatics analysis showed that MaAmyB represents a novel GH13 subfamily, designated GH13_42, currently with 165 members, all in Gram-positive soil dwelling bacteria, mostly Streptomyces. All members have an unusually large catalytic domain (AB-regions), due to three insertions compared to established α-amylases, and an aberrant C-region, which has only 30% identity to established GH13 C-regions. Most GH13_42 members have three N-terminal domains (2 CBM25 and 1 FNIII). This is unusual as starch binding domains are commonly found at the C-termini of α-amylases. The evolution of the multi-domain M. aurum B8.A MaAmyA and MaAmyB enzymes is discussed. PMID:27808246

  2. Slides for AMI CHEP presentation: Looking back on 10 years of the ATLAS Metadata Interface. Reflections on architecture, code design and development methods.

    CERN Document Server

    Fulachier, J; The ATLAS collaboration; Albrand, S; Lambert, F

    2013-01-01

    . The “ATLAS Metadata Interface” framework (AMI) has been developed in the context of ATLAS, one of the largest scientific collaborations. AMI can be considered to be a mature application, since its basic architecture has been maintained for over 10 years. In this paper we describe briefly the architecture and the main uses of the framework within the experiment (TagCollector for release management and Dataset Discovery). These two applications, which share almost 2000 registered users, are superficially quite different, however much of the code is shared and they have been developed and maintained over a decade almost completely by the same team of 3 people. We discuss how the architectural principles established at the beginning of the project have allowed us to continue both to integrate the new technologies and to respond to the new metadata use cases which inevitably appear over such a time period.

  3. Ambient ionization-accurate mass spectrometry (AMI-AMS) for the identification of nonvisible set-off in food-contact materials.

    Science.gov (United States)

    Bentayeb, Karim; Ackerman, Luke K; Begley, Timothy H

    2012-02-29

    Set-off is the unintentional transfer of substances used in printing from the external printed surface of food packaging to the inner, food-contact surface. Ambient ionization-accurate mass spectrometry (AMI-AMS) detected and identified compounds from print set-off not visible to the human eye. AMI mass spectra from inner and outer surfaces of printed and nonprinted food packaging were compared to detect and identify nonvisible set-off components. A protocol to identify unknowns was developed using a custom open-source database of printing inks and food-packaging compounds. The protocol matched print-related food-contact surface ions with the molecular formulas of common ions, isotopes, and fragments of compounds from the database. AMI-AMS was able to detect print set-off and identify seven different compounds. Set-off on the packaging samples was confirmed using gas chromatographic-mass spectrometric (GC-MS) analysis of single-sided solvent extracts. N-Ethyl-2(and 4)-methylbenzenesulfonamide, 2,4-diphenyl-4-methyl-1(and 2)-pentene, and 2,4,7,9-tetramethyl-5-decyne-4,7-diol were present on the food-contact layer at concentrations from 0.21 to 2.7 ± 1.6 μg dm⁻², corresponding to nearly milligram per kilogram concentrations in the packaged food. Other minor set-off compounds were detected only by AMI-AMS, a fast, simple, and thorough technique to detect and identify set-off in food packaging.

  4. The effect of acute Lithium and AMI-193, a new 5HT2 antagonist, on Apomorphine-induced pecking in pigeon

    Directory of Open Access Journals (Sweden)

    Bagheri T

    2002-06-01

    Full Text Available Intramascular (IM administration of apomorphine (a mixed D1/D2 dopamine receptors agonist 0.2-1.6 mg/kg induced pecking, a stereotype behavior in pigeons in a dose- dependent manner. In this study the effect of lithium (Li+, 240 mg/kg, IM and AMI-193 (a new 5-HT2 antagonist, 0.003 mg/pigeon on apomorphine-induced peking (AIP were investigated. This study showed that Li+ and AMI-193 did not induce pecking by itself but administration of each of these agents before apomorphine increased and decreased the AIP (apomor-phine 0.8 mg/kg respectively whereas concomitant use of Li+ (240 mg/kg IM and AMI-193 decreased AIP significantly. These results suggested that 5-HT2 antagonists inhibit the inhibitory effect of serotonin on the dopamine release in the raphe-striatal pathway but Li+ can modulate dopamine and serotonin function by different mechanisms and decrease this effect. As a result, it is mechanisms and decrease this effect. As a result, it is concluded serotonin can decrease the AIP through 5-HT2 receptors indirectly by decrease the dopamine release.

  5. Gender differences in presentation, management, and in-hospital outcomes for patients with AMI in a lower-middle income country: evidence from Egypt.

    Directory of Open Access Journals (Sweden)

    Neel M Butala

    Full Text Available BACKGROUND: Many studies in high-income countries have investigated gender differences in the care and outcomes of patients hospitalized with acute myocardial infarction (AMI. However, little evidence exists on gender differences among patients with AMI in lower-middle-income countries, where the proportion deaths stemming from cardiovascular disease is projected to increase dramatically. This study examines gender differences in patients in the lower-middle-income country of Egypt to determine if female patients with AMI have a different presentation, management, or outcome compared with men. METHODS AND FINDINGS: Using registry data collected over 18 months from 5 Egyptian hospitals, we considered 1204 patients (253 females, 951 males with a confirmed diagnosis of AMI. We examined gender differences in initial presentation, clinical management, and in-hospital outcomes using t-tests and χ(2 tests. Additionally, we explored gender differences in in-hospital death using multivariate logistic regression to adjust for age and other differences in initial presentation. We found that women were older than men, had higher BMI, and were more likely to have hypertension, diabetes mellitus, dyslipidemia, heart failure, and atrial fibrillation. Women were less likely to receive aspirin upon admission (p<0.01 or aspirin or statins at discharge (p = 0.001 and p<0.05, respectively, although the magnitude of these differences was small. While unadjusted in-hospital mortality was significantly higher for women (OR: 2.10; 95% CI: 1.54 to 2.87, this difference did not persist in the fully adjusted model (OR: 1.18; 95% CI: 0.55 to 2.55. CONCLUSIONS: We found that female patients had a different profile than men at the time of presentation. Clinical management of men and women with AMI was similar, though there are small but significant differences in some areas. These gender differences did not translate into differences in in-hospital outcome, but

  6. Anlysis of characters of young AMI%青年人急性心肌梗死临床特点及冠脉造影结果分析

    Institute of Scientific and Technical Information of China (English)

    荆忻; 荆忱; 贾绍斌

    2011-01-01

    Objective To study and analyze risk factor, clinic characteristics and coronary lesions in young AMI.Methods The clinical data including results of coronary angiography of 56 (<45 years old) young and elderly(≥60 years old) AMI patients were retrospectively analyzed.Results Smoking, male, obesity, family history, and hihertriglyceride levels of cardiovascular disease were more common in young cases (P<0.01 or P<0.05).The typical chest pain symptom often more in young group and complications less than eldly group(P<0.01).Focal and single-vessel appeared more in young group , while multi-vessel lesions more in elderly group(P<0.05).Conclusion Smoking, male, positive family history and hyperlipidemia were are risk factors for young AMI.Young AMI also had typical symptoms and fewer complications.Normal coronary artery is frequent in young patients.%目的:探讨青年急性心肌梗死(AMI)患者危险因素、临床特点、冠状动脉病变特点.方法:对青年组56例(<45岁)AMI患者、老年组156例(≥60岁)AMI患者的临床特点及冠脉造影结果进行对比分析.结果:青年AMI组危险因素如吸烟、男性、超重、心血管病家族吏、血脂异常明显多于老年组(P<0.01或P<0.05),发病时症状较老年人典型(P<0.01),并发症明显少于老年患者(P<0.01).冠脉造影(CAG)显示青年患者冠脉病变以单支、局限性病变为主,而老年组则以多支病变多见(P<0.05).结论:青年人AMI患者吸烟、男性、家族史、血脂异常是其发病的重要危险因素;发病时症状典型、并发症少;CAG显示冠脉正常者占有一定比例.

  7. A starch-binding domain identified in α-amylase (AmyP) represents a new family of carbohydrate-binding modules that contribute to enzymatic hydrolysis of soluble starch.

    Science.gov (United States)

    Peng, Hui; Zheng, Yunyun; Chen, Maojiao; Wang, Ying; Xiao, Yazhong; Gao, Yi

    2014-04-02

    A novel starch-binding domain (SBD) that represents a new carbohydrate-binding module family (CBM69) was identified in the α-amylase (AmyP) of the recently established alpha-amylase subfamily GH13_37. The SBD and its homologues come mostly from marine bacteria, and phylogenetic analysis indicates that they are closely related to the CBM20 and CBM48 families. The SBD exhibited a binding preference toward raw rice starch, but the truncated mutant (AmyPΔSBD) still retained similar substrate preference. Kinetic analyses revealed that the SBD plays an important role in soluble starch hydrolysis because different catalytic efficiencies have been observed in AmyP and the AmyPΔSBD.

  8. AMI : Augmented Michelson Interferometer

    OpenAIRE

    Furio, David; Hachet, Martin; Guillet, Jean-Paul; Bousquet, Bruno; Fleck, Stéphanie; Reuter, Patrick; Canioni, Lionel

    2015-01-01

    International audience; Experiments in optics are essential for learning and understanding physical phenomena. The problem with these experiments is that they are generally time consuming for both their construction and their maintenance, potentially dangerous through the use of laser sources, and often expensive due to high technology optical components.We propose to simulate such experiments by way of hybrid systems that exploit both spatial augmented reality and tangible interaction. In pa...

  9. Variations in coal maceral chemistry with rank advance in the German Creek and Moranbah Coal Measures of the Bowen Basin, Australia, using electron microprobe techniques

    Energy Technology Data Exchange (ETDEWEB)

    Ward, Colin R.; Li, Zhongsheng; Gurba, Lila W. [School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, 2052 (Australia)

    2005-07-20

    Variations in the elemental composition of individual macerals in seams from the Permian German Creek and Moranbah Coal Measures in the Bowen Basin of Queensland have been studied over a wide range of coal ranks, using light-element electron microprobe techniques, to establish the coalification tracks of key macerals in a single coal-bearing interval from subbituminous through bituminous coal to anthracite. Vitrinite reflectance (Rv{sub max}) in the seams studied increases from 0.39% in the western part of the basin to over 3.5% in the east, apparently due to increases in burial depth. The study extends significantly the rank range covered by previous work on elemental analysis of individual macerals in the Gunnedah Basin, and provides a more useful basis than whole-coal analysis to evaluate the performance of coals in different utilisation processes. The microprobe results show that the carbon content of the telocollinite increases dramatically from 66% to 90% as the vitrinite reflectance of the coals (Rv{sub max}) increases from 0.39% to around 1.75%, but increases only slightly, from 90% to 91%, as Rv{sub max} increases from 1.75% to 3.52%. Oxygen decreases from around 26% to approximately 5% as Rv{sub max} increases from 0.39% to around 1.75%, and then decreases only very slightly into the anthracite range. The nitrogen content of the telocollinite in these coals also appears to decrease slightly with rank advance, and appears moreover to display a relatively abrupt drop at around 2% Rv{sub max}. This may be associated with the development of ammonium illite in the mineral matter. Organic sulphur in the telocollinite, on the other hand, seems to remain essentially constant with rank advance, at least in this particular succession. In contrast to vitrinite, fusinite and inertodetrinite have significantly higher but somewhat more constant carbon contents, varying only from around 81% to 93% C over the rank range studied. Oxygen in these macerals decreases from

  10. Bower ratio-energy balance associated errors in vineyards under dripping irrigation Erros associados pela razão de bowen ao balanço de energia em parreirais sob irrigação por gotejamento

    Directory of Open Access Journals (Sweden)

    José Monteiro Soares

    2007-08-01

    Full Text Available This study was conducted at the Bebedouro Experimental Station in Petrolina-PE, Brazil, to evaluate the errors associated to the application of the Bowen ratio-energy balance in a 3-years old vineyard (Vitis vinifera, L, grown in a trellis system, irrigated by dripping. The field measurements were taken during fruiting cycle (July to November, 2001, which was divided into eigth phenological stages. A micrometeorological tower was mounted in a grape-plants row in which sensors of net radiation, global solar radiation and wind speed were installed at about 1.0 m above the canopy. Also in the tower, two psicometers were installed at two levels (0.5 and 1.8 m above the vineyard canopy. Two soil heat flux plates were buried at 0.02 m beneath the soil surface. All these sensors were connected to a Data logger 21 X of Campbell Scientific Inc., programmed for collecting data once every 5 seconds and storage averages for every 15 minutes. A comparative analysis were made among four Bowen ratio accepting/rejecting rules, according to the methodology proposed by Spano et al. (2000: betar1 - values of beta calculated by Bowen (1926 equation; betar2 - values of beta as proposed by Verma et al. (1978 equation; betar3 - exclusion of the beta values obtained as recommended by Unland et al. (1996 and betar4 - exclusion of the beta values calculated as proposed by Bowen (1926, out of the interval (-0.7 Este estudo foi conduzido na Estação Experimental de Bebedouro, Petrolina-PE, Brasil, para avaliar os erros associados com a aplicação do balanço de energia com base na razão de Bowen em um parreiral (Vitis vinifera, L com três anos de idade, conduzido em latada, sob irrigação por gotejamento. As medições foram feitas durante o ciclo produtivo de julho a novembro de 2001, que foi dividido em oito estádios fenológicos. Numa torre micrometeorológica localizada no centro do parreiral, foram instalados a 1,00 m acima do dossel da videira, os seguintes

  11. Erythropoietin prevention trial of coronary restenosis and cardiac remodeling after ST-elevated acute myocardial infarction (EPOC-AMI): a pilot, randomized, placebo-controlled study.

    Science.gov (United States)

    Taniguchi, Norimasa; Nakamura, Takeshi; Sawada, Takahisa; Matsubara, Kinya; Furukawa, Keizo; Hadase, Mitsuyoshi; Nakahara, Yoshifumi; Nakamura, Takashi; Matsubara, Hiroaki

    2010-11-01

    Erythropoietin (EPO) enhances re-endothelialization and anti-apoptotic action. Larger clinical studies to examine the effects of high-dose EPO are in progress in patients with acute myocardial infarction (AMI). The aim of this multi-center pilot study was to investigate the effect of `low-dose EPO' (6,000 IU during percutaneous coronary intervention (PCI), 24 h and 48 h) in 35 patients with a first ST-elevated AMI undergoing PCI who was randomly assigned to EPO or placebo (saline) treatment. Neointimal volume, cardiac function and infarct size were examined in the acute phase and 6 months later (ClinicalTrials.gov identifier: NCT00423020). No significant regression in in-stent neointimal volume was observed, whereas left ventricular (LV) ejection fraction was significantly improved (49.2% to 55.7%, P=0.003) and LV end-systolic volume was decreased in the EPO group (47.7 ml to 39.0 ml, P=0.036). LV end-diastolic volume tended to be reduced from 90.2% to 84.5% (P=0.159), whereas in the control group it was inversely increased (91.7% to 93.7%, P=0.385). Infarction sizes were significantly reduced by 38.5% (P=0.003) but not in the control group (23.7%, P=0.051). Hemoglobin, peak creatine kinase values, and CD34(+)/CD133(+)/CD45(dim) endothelial progenitors showed no significant changes. No adverse events were observed during study periods. This is a first study demonstrating that short-term `low-dose' EPO to PCI-treated AMI patients did not prevent neointimal hyperplasia but rather improved cardiac function and infarct size without any clinical adverse effects.

  12. Evolution in Cloud Population Statistics of the MJO. From AMIE Field Observations to Global-Cloud Permitting Models final report Version 1

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Min [Univ. of Wyoming, Laramie, WY (United States)

    2016-01-08

    Methods of convective/stratiform precipitation classification and surface rain rate estimation based on the Atmospheric Radiation Measurement (ARM) program cloud radar measurements were developed and evaluated. Simultaneous and collocated observations of the Ka-band ARM zenith radar (KAZR), two scanning precipitation radars (NCAR S-PolKa and Texas A&M University SMART-R), and surface precipitation during the DYNAMO/AMIE field campaign were used. The motivation of this study is to apply the unique long-term ARM cloud radar observations without accompanying precipitation radars to the study of cloud lifecycle and precipitation features under different weather and climate regimes.

  13. Heme oxygenase-1 is involved in nitric oxide- and cGMP-induced α-Amy2/54 gene expression in GA-treated wheat aleurone layers.

    Science.gov (United States)

    Wu, Mingzhu; Wang, Fangquan; Zhang, Chen; Xie, Yanjie; Han, Bin; Huang, Jingjing; Shen, Wenbiao

    2013-01-01

    Here, α-Amy2/54 gene expression was used as a molecular probe to investigate the interrelationship among nitric oxide (NO), cyclic GMP (cGMP), and heme oxygenase-1 (HO-1) in GA-treated wheat aleurone layers. The inducible expressions of α-Amy2/54 and α-amylase activity were respectively amplified by two NO-releasing compounds, sodium nitroprusside (SNP) and spermine NONOate, in a GA-dependent fashion. Similar responses were observed when an inducer of HO-1, hemin-or one of its catalytic products, carbon monoxide (CO) in aqueous solution-was respectively added. The SNP-induced responses, mimicked by 8-bromoguanosine 3',5'-cyclic monophosphate (8-Br-cGMP), a cGMP derivative, were NO-dependent. This conclusion was supported by the fact that endogenous NO overproduction was rapidly induced by SNP, and thereafter induction of α-Amy2/54 gene expression and increased α-amylase activity were sensitive to the NO scavenger. We further observed that the above induction triggered by SNP and 8-Br-cGMP was partially prevented by zinc protoporphyrin IX (ZnPPIX), an inhibitor of HO-1. These blocking effects were clearly reversed by CO, confirming that the above response was HO-1-specific. Further analyses showed that both SNP and 8-Br-cGMP rapidly up-regulated HO-1 gene expression and increased HO activity, and SNP responses were sensitive to cPTIO and the guanylate cyclase inhibitor 6-anilino-5,8-quinolinedione (LY83583). Molecular evidence confirmed that GA-induced GAMYB and ABA-triggered PKABA1 transcripts were up-regulated or down-regulated by SNP, 8-Br-cGMP or CO cotreated with GA. Contrasting changes were observed when cPTIO, LY83583, or ZnPPIX was added. Together, our results suggested that HO-1 is involved in NO- and cGMP-induced α-Amy2/54 gene expression in GA-treated aleurone layers.

  14. Estimativa do balanço de energia em cambarazal e pastagem no norte do Pantanal pelo método da razão de Bowen Estimate of energy balance in cambarazaland pasture in the north of Pantanal by Bowen ratio method

    Directory of Open Access Journals (Sweden)

    Marcelo Sacardi Biudes

    2009-06-01

    Full Text Available O estudo do balanço de energia de uma superfície vegetada e a atmosfera é importante para caracterizar o microclima local, identificar interações entre variáveis ambientais e a vegetação, e identificar efeitos das atividades antropogênicas. O objetivo deste trabalho foi estimar a variação sazonal do balanço de energia pelo método da razão de Bowen em uma área de vegetação monodominante de Cambará na RPPN SESC-Pantanal e uma área de pastagem na Fazenda Experimental da UFMT. Os componentes do balanço de energia apresentaram sazonalidade, com maiores médias na estação chuvosa nas duas áreas de estudo. No cambarazal houve maior variação do fluxo de calor latente da estação seca para a chuvosa que na pastagem. Entretanto, a variação sazonal do fluxo de calor sensível foi menor no cambarazal que na pastagem, devido ao efeito termo-regulador do cambarazal, em função da maior biomassa. A energia disponível aos dois sítios foi destinada prioritariamente em fluxo de calor latente, 80,0% no cambarazal e 56,6% na pastagem, seguido pelo fluxo de calor sensível, 19,1 e 42,9%, e pelo fluxo de calor no solo, 0,3 e 7,2%.The energy balance study of a vegetated surface and atmosphere is important to characterize the local microclimate, identify interactions among environmental variables and the vegetation and to identify anthropogenic activities effects. The objective of this work was estimate the seasonality of energy balance by Bowen ratio method in a monodominant vegetation of Cambará area in the RPPN SESC-Pantanal and a pasture area in UFMT's Experimental Farm. The energy balance components presented seasonality, with larger averages at the rainy station in two areas of study. In the cambarazal was a higher variation of the latent heat flux of the dry season for the rainy season that in the pasture. However, the seasonal variation of the sensible heat flux in the cambarazal was lower than in the pasture, due to the thermo

  15. Measuring Evapotranspiration of five Alley Cropping systems in Germany using the Eddy-Covariance- and Bowen-Ratio Energy-Balance methods

    Science.gov (United States)

    Markwitz, Christian; Knohl, Alexander; Siebicke, Lukas

    2017-04-01

    The inclusion of trees into the agricultural landscape of Europe is gaining popularity as a source for energy production. Fast growing tree species such as poplar or willow are included as short rotation coppice or alley cropping systems, which consist of tree alleys interleaved by annual rotating crops or perennial grasslands. Estimating turbulent fluxes of those systems using the eddy-covariance- (ECEB) and bowen-ratio energy-balance (BREB) method is challenging due to the methods limitation to horizontally homogeneous terrain and steady state conditions. As the conditions are not fulfilled for those systems the energy-balance is commonly not fully closed, with the non-closure being site specific. An underestimation of measured heat fluxes leads to an overestimation of the latent heat fluxes inferred from the ECEB method. The aim of our study is to 1) quantify the site specific non-closure of the energy-balance and 2) characterize the performance of both methods, compared to direct eddy-covariance measurements using a high frequency infra-red gas analyzer (LI-7200, Licor Inc.). To assess continuous evapotranspiration (ET) rates on a 30-minute time scale we installed a combined ECEB and BREB system at five alley cropping and five agricultural reference sites across Germany. For time periods of four weeks we performed direct eddy covariance flux measurements for H2O and CO2 over one crop- and one grassland alley cropping- and their respective reference systems during the growing season of 2016. We found a non-closure between 21 and 26 % for all sites, considering all day- and night-time data. The residual energy was highest during the morning and lowest in the afternoon. Related to that the energy-balance ratio (EBR), i.e. the ratio between the turbulent heat fluxes and available energy, was below one in the morning hours and increased slightly during the day up to 1.8, until the EBR decreased sharply after sunset. The EBR correlated to the daily cycle of solar

  16. Clinical Effect of 5-aminolevulinic Acid Photodynamic Treating 10 Cases Bowen' s Disease%5-氨基酮戊酸光动力疗法治疗鲍温病10例疗效观察

    Institute of Scientific and Technical Information of China (English)

    熊林; 陆延娜; 万静; 魏亚东; 赵延东

    2012-01-01

    目的 观察5-氨基酮戊酸光动力疗法治疗鲍温病的临床疗效.方法 将20例鲍温病患者分为两组,各10例.治疗组予5-氨基酮戊酸外涂于皮损处,3h后予红光照射20min,能量密度100~120 J/cm2,1次/周,共4周.对照组外涂5-氟尿嘧啶软膏皮损处,2次/d,共4周.结果 治疗组完全缓解率为90.00%,对照组为30.00%,两组间完全缓解率比较,差异有统计学意义(P<0.05).且治疗组均未见严重不良反应,对照组有溃疡及瘢痕等不良反应.结论 5-氨基酮戊酸光动力疗法治疗鲍温病临床疗效较好,且无严重不良反应,值得临床推广应用.%Objective To observe the clinical effect of 5-aminolevulinic acid photodynamic therapy ( ALA-PDT) treating Bowen' s disease. Methods Twonty cases of Bowen' s disease were randomly divided into treatment group and control. Each group has 10 cases. Treatment group: applied 5-aminolevulinic acid (ALA) to the skin lesions, 3 hours later red light irradiated 20min, energy density was 100 ~ 120 J/cm2, one time a week for 4 weeks. Control group: smearing 5-fluorouracil cream(5-Fu ointment) on skin lesions,, twice daily for 4 weeks. Results Completely remission rate was 90. 00% in treatment group and 30. 00% in control. The difference between them had statistical significance(P <0.05). There were no serious side effects in the treatment group, but the control group appeared ulcer, scar and other side effects. Conclusion 5-aminolevulinic acid photodynamic is a good therapeutic method for Bowen' s disease.

  17. Evapotranspiração do capim Tanzânia obtida pelo método de razão de Bowen e lisímetro de pesagem

    OpenAIRE

    2005-01-01

    A irrigação de pastagens no Brasil apresentou crescimento acentuado nos últimos anos. No entanto, em função da ausência de pesquisas sobre a aplicação de água em pastagens, o manejo da irrigação não vem sendo realizado de maneira racional. Com o objetivo de contribuir para suprir a carência de informações, neste trabalho, comparou-se a evapotranspiração do capim Tanzânia estimada pelo método de razão de Bowen com a medida por lisímetro de pesagem. O experimento foi conduzido em Piracicaba - S...

  18. 艾兹拉·庞德、艾米·洛威尔与李白的诗歌情缘%The Love of Ezra Pound and Amy Lowell for Libai’s Poems

    Institute of Scientific and Technical Information of China (English)

    陈怀志; 王拉沙; 罗伦全; 赵彤; 胡竹

    2012-01-01

      Libai is one great poet in Tang dynasty. Ezra Pound and Amy Lowell are two representatives of American Imagists peotry in the early twentith century. Ezra Pound an Amy Lowell didn’t understand Chinese,but both of them deeply loved Libai’s poems and translated many of them in the early twentith century.%  李白是中国唐代伟大诗人,艾兹拉·庞德(Ezra Pound)和艾米·洛威尔(Amy Lowell)是20世纪初美国诗歌意象派的代表。艾兹拉·庞德和艾米·洛威尔不懂中文,却在20世纪初和李白诗歌结下了深厚的情缘。

  19. GuitarAMI : desenvolvimento, implementação e performance de um instrumento musical aumentado que explora possibilidades de modificação de características intrínsecas do violão

    OpenAIRE

    Eduardo Aparecido Lopes Meneses

    2016-01-01

    Este trabalho relata a construção e utilização de um AMI (acrônimo de Augmented Musical Instrument, ou instrumento musical aumentado) intitulado GuitarAMI e criado para execução de emph{patches} programados em Pure Data com a finalidade de modificar algumas características intrínsecas do violão. É traçado um panorama histórico sobre a música eletroacústica mista com suporte dinâmico e são analisados alguns AMI que utilizam violão ou guitarra elétrica em sua construção. São abordados também as...

  20. Caracterización bioquímica de AmiJ33, una amilasa de Bacillus amyloliquefaciens aislada de suelos cultivados con caña de azúcar en la región del Papaloapan

    Directory of Open Access Journals (Sweden)

    J. J. Montor-Antonio

    2014-01-01

    Full Text Available La amilasa (E.C. 3.2.1.1 de Bacillus amyloliquefaciens JJC33M (AmiJ33 fue producida por fermentación sumergida. Se probó el efecto de peptona, extracto de levadura, Ca+2 y glicina en la producción de AmiJ33. El extracto de levadura y Ca+2 tuvieron un efecto positivo sobre la síntesis de AmiJ33. La enzima fue recuperada mediante precipitación a saturación al 60% con (NH42SO4. El peso molecular aproximado de la enzima purificada fue de 50 kDa. Así mismo, se evaluó el efecto del pH y la temperatura sobre la actividad enzimática, concluyendo que los valores más altos de actividad se observaron a pH 6.0 y 80°C, respectivamente. En condiciones ligeramente ácidas (pH 4.0 y 5.0, AmiJ33 mantuvo el 72% de su actividad. AmiJ33 fue estable por 3 h a 40°C, y por 30 min a 45 y 50°C, conservando el 88 y 82% de actividad residual. A 60°C, la actividad disminuyó 40%. La actividad de AmiJ33 se incrementó 50.27% con b- mercaptoetanol, no fue inhibida por EDTA y se inhibió totalmente con SDS.

  1. Select Biochemical Indexes Used for the AMI Earlier Diagnosis%从动物模型角度探讨AMI早期诊断中生化指标的选择

    Institute of Scientific and Technical Information of China (English)

    左雪梅; 孙晨光

    2003-01-01

    Objective To ligate the coronary artery of left descending anterior branch of the New Zealand Rabbit and toform AMI model,to supervise and observe different period biochemistry indexes(CK, CK- MB, ALT, AST, M - AST, LDH,LDH-isozyme,a- HBDH,TNI,K, CRP, SCRP),to select a set of combine indexes used for the AMI earlier diagnose andapplication in clinical. Method Anaesthesia rabbit and ligate the coronary artery of left descending anteior branch of the NewZealand Rabbit and to form AMI model. Adopt the blood from rabbit humerus vein to examine before ligation and after ligation30min, 1h,2h,3h,4h,5h,6h,7h,8h. Result The most sensitivity biochemistry index is TNT which display positive in 1h. CKin3h,CK- MB, CRP in 5h has been increasing. But ALT, AST, LDH and its isozyme, a- HBDH, M- AST is no moredifference between ligature fore- and - aft. It was reported that K,SCRP,etc. reaction protein stimulate would be increased.but no embodiment in the task. Conchusions It should be first select TNT in the diagnosis AMI indexes. It is the mostsensitive index for evaluating the tiny deal of myocardial,replacing the CK- MB become the newly AMI diagnostic standards.The next in order are the CK,CK- MB and CRP.As far as ALT,AST,LDH and its isozyme, M - AST etc. are no longerfunction in the diagnosis AMI.

  2. AmyI-1-18, a cationic α-helical antimicrobial octadecapeptide derived from α-amylase in rice, inhibits the translation and folding processes in a protein synthesis system.

    Science.gov (United States)

    Taniguchi, Masayuki; Ochiai, Akihito; Fukuda, Shun; Sato, Teppei; Saitoh, Eiichi; Kato, Tetsuo; Tanaka, Takaaki

    2016-10-01

    In our previous study, we used a cell-free rapid translation system (RTS), which is an in vitro protein synthesis system based on Escherichia coli lysate, for evaluating the inhibition of green fluorescent protein (GFP) synthesis by pyrrhocoricin. In this study, using an RTS, we evaluated the inhibition of GFP synthesis by AmyI-1-18, an antimicrobial octadecapeptide. We found that, similarly to pyrrhocoricin, AmyI-1-18 inhibited GFP synthesis in the RTS in a concentration-dependent manner. In addition, the blockage of transcription and translation steps in the RTS was individually estimated using RT-PCR after gene expression to determine the mRNA products and using sodium dodecyl sulfate-polyacrylamide gel electrophoresis to determine the amounts of GFP expressed from purified mRNA, respectively. The results demonstrated that the inhibition of GFP synthesis by AmyI-1-18 did not occur at the transcription step but rather at the translation step. Furthermore, we assessed the inhibition of DnaK-mediated refolding of chemically denatured luciferase by AmyI-1-18; AmyI-1-18 inhibited the protein folding activity of the ATP-dependent DnaK/DnaJ molecular chaperone system in a concentration-dependent manner. Surface plasmon resonance (SPR) analysis showed that AmyI-1-18 strongly bound to RNA with a KD value of 1.4 × 10(-8) M but not to DNA and that AmyI-1-18 specifically bound to DnaK with a KD value of 4.4 × 10(-6) M. These SPR analysis results supported the results obtained in both the RTS and the molecular chaperone system. These results demonstrated that both RNA and DnaK are most likely the target of AmyI-1-18 in the protein synthesis system. Copyright © 2016 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  3. An Analysis of the Absurdity in Amy Tan’s Saving Fish from Drowning%《沉没之鱼》的荒诞色彩解读

    Institute of Scientific and Technical Information of China (English)

    张雨

    2015-01-01

    Amy Tan’s Saving Fish from Drowning is featured with the absurdity. In this novel,Amy Tan adopts broader and newer narrative methods by giving up her proficient autobiographical narrative about Chinese Americans. Tan annotates the social reality solemnly and arouses readers to retrospect it more deeply by portraying a group of absurd people. The absurd and incredible events commonly seen in the story show heavy sarcasm to the distorting society reverse the contingency and the inevitability and express the Amy’s regret and pity toward the ab⁃surdity in the factual society. The ghost narration and the prophetic narration create a sense of strangeness and mys⁃tery in readers who are shocked at the artistic effect of Amy’s writing and inspired to discover the philosophical ab⁃surdity in the story.%谭恩美的《沉没之鱼》是一部充满荒诞色彩的作品。小说借助于幽灵叙事和预示性叙事,创造出熟悉的陌生感和神秘感,带给读者震撼人心的艺术效果和极富启示意义的哲学思考,大大强化了作品的荒诞色彩。随处可见的荒诞情节辛辣地讽刺着扭曲的社会,颠倒了偶然与必然的关系,反映了作者对荒诞现实社会的无奈与遗憾。

  4. Clinical Impact of Rapid Reduction of Low-Density Lipoprotein Cholesterol Level on Long-Term Outcome of Acute Myocardial Infarction in the Statin Era: Subanalysis of the ALPS-AMI Study.

    Directory of Open Access Journals (Sweden)

    Takashi Miura

    Full Text Available The optimal period to achieve target percent reduction of low-density lipoprotein cholesterol (LDL-C level for secondary prevention of acute myocardial infarction (AMI is not well established.The Assessment of Lipophilic vs. Hydrophilic Statin Therapy in AMI (ALPS-AMI study enrolled 508 patients (mean age, 66.0± 11.6 years; 80.6% male who were hospitalized for AMI and underwent percutaneous coronary intervention (PCI. Of these patients, 81 were excluded because of the absence of LDL-C measurements at 4 weeks after randomization. In the remaining 427 patients, the target LDL-C level reduction of ≥30% was achieved and not reached within 4 weeks after randomization in 204 cases (early reduction group and 223 cases (late reduction group. The groups were formed prospectively and analyzed with regard to the composite end point (major adverse cardiovascular event [MACE]: all-cause death, myocardial infarction, and stroke and clinical outcomes.MACE were significantly more frequent in the late reduction group compared to the early reduction group (9.4% vs. 3.4%, P = 0.013. The incidence of cardiac deaths was also significantly higher in the late reduction group (3.1% vs. 0.5%, P = 0.044. On age-adjusted Cox proportional hazards analysis in statin-naïve patients, percent reduction of LDL-C level during the initial 4 weeks (HR, 0.98; 95% CI: 0.97-0.99, P = 0.042 and baseline LDL-C level (HR, 0.98; 95% CI: 0.97-0.99, P = 0.033 predicted adverse events.Rapid reduction of LDL-C level is strongly associated with favorable outcome in patients with AMI.

  5. Diagnostyka i postępowanie w otępieniu z ciałami Lewy’ego: aktualne zalecenia i nierozwiązane problemy

    Directory of Open Access Journals (Sweden)

    Tomasz Sobów

    2013-12-01

    Full Text Available Otępienie z ciałami Lewy’ego (dementia with Lewy bodies, DLB jest uważane za drugą co do częstości, po chorobie Alzheimera, przyczynę otępień pierwotnie zwyrodnieniowych. Mimo że w badaniach epidemiologicznych i kliniczno-neuropatologicznych potwierdzono jego znaczne rozpowszechnienie, pozostaje względnie rzadko rozpoznawane. Najczęściej mylnie wskazuje się na choroby Alzheimera lub Parkinsona, rzadziej psychozę (zwykle wiązaną z zaawansowanym wiekiem chorych. Nieprawidłowa diagnoza skutkuje leczeniem nieskutecznym, a z powodu nadwrażliwości na nawet niewielkie dawki leków przeciwpsychotycznych u chorych z DLB – często skrajnie niebezpiecznym. Diagnostyka różnicowa obejmuje w głównej mierze różnicowanie z innymi zespołami pierwotnie zwyrodnieniowymi, w tym z najbardziej zbliżonymi fenotypowo – chorobą Alzheimera z parkinsonizmem i otępieniem w chorobie Parkinsona. Różnicowanie i ustalenie poprawnego rozpoznania ułatwia stosowanie klinicznych kryteriów diagnostycznych oraz badań dodatkowych. Najważniejszą kwestią pozostaje stwierdzenie charakterystycznego obrazu klinicznego psychiatrycznego i neurologicznego oraz sekwencja wystąpienia otępienia i parkinsonizmu. Prawidłowe rozpoznanie i posługiwanie się strategiami terapeutycznymi z pogranicza neurologii i psychiatrii pozwala na uzyskanie optymalnych popraw u większości pacjentów. Kluczowe pozostaje dziś zastosowanie inhibitorów cholinesteraz (leków wpływających korzystnie na funkcje poznawcze, ale także na niektóre objawy behawioralne, w tym psychotyczne oraz lewodopy (w celu kontroli objawów ruchowych. Leki przeciwpsychotyczne należy co do zasady stosować bardzo ostrożnie, a lekiem z wyboru jest obecnie kwetiapina. Istotny problem stanowi także terapia współistniejących zaburzeń snu związanych z fazą REM oraz zaburzeń autonomicznych.

  6. Outcome of the HORIZONS-AMI trial: bivalirudin enhances long-term survival in patients with ST-elevation myocardial infarction undergoing angioplasty

    Directory of Open Access Journals (Sweden)

    Feldman DN

    2012-02-01

    Full Text Available Ashish Shah, Dmitriy N FeldmanGreenberg Division of Cardiology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USAAbstract: Cardiovascular disease is the leading cause of death in the US. For patients with ST-elevation myocardial infarction (STEMI, urgent reperfusion of the culprit arterial occlusion, often achieved via primary percutaneous coronary intervention (PCI, reduces post-MI mortality and other major adverse cardiovascular events (MACE. Adjunctive antithrombotic and antiplatelet therapies are used during PCI to reduce MACE rates. Currently, a variety of antithrombotic options are available for peri-procedural use. The most commonly used agents include unfractionated heparin or low molecular weight heparin ± glycoprotein IIb/IIIa inhibitors (GPI. These agents reduce the rates of peri-procedural ischemic and thrombotic events, though these benefits come at the cost of an increase in bleeding complications. Bivalirudin is a direct thrombin inhibitor with a short half-life and linear pharmacokinetics, which results in predictable serum concentrations and anticoagulant effect. Bivalirudin has emerged as an efficacious and safe alternative to heparin plus GP IIb/IIIa inhibitors in both stable coronary artery disease and acute coronary syndrome patients. In the HORIZONS-AMI trial, monotherapy with bivalirudin was compared with the combination of heparin and a GPI in a large population of patients with STEMI who underwent primary PCI. Bivalirudin treatment was associated with improved event-free survival at 30 days and reduced rates of major bleeding. Based on the results of the trial, the American College of Cardiology/American Heart Association and European Society of Cardiology guidelines have incorporated recommendations for bivalirudin use in the setting of STEMI. Recently, 3-year follow-up data from the HORIZONS-AMI cohort were published, demonstrating sustained benefits in patients treated with bivalirudin

  7. Mutation of EMG1 causing Bowen-Conradi syndrome results in reduced cell proliferation rates concomitant with G2/M arrest and 18S rRNA processing delay.

    Science.gov (United States)

    Armistead, Joy; Hemming, Richard; Patel, Nehal; Triggs-Raine, Barbara

    2014-06-01

    Bowen-Conradi syndrome (BCS) is a lethal autosomal recessive disorder caused by a D86G substitution in the protein, Essential for Mitotic Growth 1 (EMG1). EMG1 is essential for 18S rRNA maturation and 40S ribosome biogenesis in yeast, but no studies of its role in ribosome biogenesis have been done in mammals. To assess the effect of the EMG1 mutation on cell growth and ribosomal biogenesis in humans, we employed BCS patient cells. The D86G substitution did not interfere with EMG1 nucleolar localization. In BCS patient lymphoblasts, cells accumulated in G2/M, resulting in reduced proliferation rates; however, patient fibroblasts showed normal proliferation. The rate of 18S rRNA processing was consistently delayed in patient cells, although this did not lead to a difference in the levels of 40S ribosomes, or a change in protein synthesis rates. These results demonstrate that as in yeast, EMG1 in mammals has a role in ribosome biogenesis. The obvious phenotype in lymphoblasts compared to fibroblasts suggests a greater need for EMG1 in rapidly dividing cells. Tissue-specific effects have been seen in other ribosomal biogenesis disorders, and it seems likely that the impact of EMG1 deficiency would be larger in the rapidly proliferating cells of the developing embryo.

  8. A propósito del tomo III y último de la «Historia de la educación occidental» de J. Bowen. Comentarios y consideraciones

    Directory of Open Access Journals (Sweden)

    Antonio VIÑAO FRAGO

    2010-03-01

    Full Text Available RESUMEN: Con la misma diferencia cuatrienal que transcurrió, entre la edición castellana y la inglesa, en los dos tomos anteriores, la editorial Herder ha publicado el tomo III de la Historia de la Educación Occidental de James Bowen, que cubre los siglos XVII a XX. Aunque ya en su día, por razones profesionales, tuvimos que hacer un profuso uso de la edición original inglesa de 1981, esta traducción nos alegra por venir a completar una de las pocas historias de la educación en lengua castellana que se hallan en el mercado. Esto sólo ya es por sí mismo satisfactorio. Mucho más si con ella se pretende, en palabras del autor, desde una perspectiva «revisionista», la «construcción de un nuevo pasado» en el que basar una «nueva moral social y educativa».

  9. The Detection and Clinical Significance of LP(a), HCY and CRP in AMI Patients%AMI患者LP(a)、HCY和CRP的检测及临床意义

    Institute of Scientific and Technical Information of China (English)

    张蓉; 张磊; 马艳辉

    2014-01-01

    目的:检测急性心肌梗死(AMI)患者治疗前后血清中脂蛋白a[Lp(a)]、同型半胱氨酸(HCY)和C-反应蛋白(CRP)的变化情况。方法采用生物化学方法测定60例试验组及30例对照组外周血中LP(a)、HCY和CRP的含量。结果 AMI患者LP(a)、HCY和CRP均显著高于对照组(P=0.001、P=0.001和P=0.007);AMI患者治疗后HCY和CRP浓度显著下降(P=0.001),Lp(a)治疗前、后差异无统计学意义(P=0.731)。结论高Lp(a)和HCY与AMI的发生有关,二者与CRP同时检测可以作为AMI的预防和疗效观察的辅助指标。%Objective To explore the changes of serum lipoprotein a [Lp (a)], homocysteiine (HCY) and C-reactive protein (CRP) in acute myocardial infarction (AMI) patients before and after treatment. Methods Biochemical method was used to detect the content of LP (a) , Hcy and CRP in peripheral blood within experiment groups (60 cases) and control groups (30 cases). Results The contents of LP(a)、HCY and CRP in AMI patients are obviously higher than those in control group (P=0.001, P=0.001和P=0.007). After treatment, HCY and CRP concentrations decreased markedly in AMI patients (P=0.001). As for Lp(a) there was no signiifcant difference after treatment. Conclusion There is a relationship between high Lp(a), Hcy and the occurring of AMI. The former two detected simultaneously with CRP can be used as the auxiliary indicators in preventing AMI and observing its curative effect.

  10. α-淀粉酶基因amyP的原核表达及酶学性质初步分析

    Institute of Scientific and Technical Information of China (English)

    赵金海; 杨灵; 张志芳; 李轶女

    2014-01-01

    α-amylase is a very important enzyme, the mass production ofα-amylase is based on microorganism fermentation in the industry at present. The gene ofα-amylases (amyP) is amplified from the genome of the thermostable strain Geobacillus. POT-5 by PCR. This gene is cloned, sequence analysis and expressed in procaryotic expression system in E.coli. This study also develops a preliminary analysis of enzyme properties about the recombinantα-amylase.%α-淀粉酶作为一种十分重要的酶制剂,目前工业上都是以微生物发酵法大规模生产的。从耐高温菌株Geobacillus. POT-5基因组中,用PCR的方法扩增得到该菌的α-淀粉酶基因,此基因被克隆、测序,并在原核Escherichia coli表达系统中进行表达,并对该重组酶的酶学性质进行初步的分析。

  11. Design of Intelligent electric service platform based on AMI%基于AMI的智能用电服务平台设计

    Institute of Scientific and Technical Information of China (English)

    陈志欣

    2014-01-01

    Intelligent electric service platform to business applications and intelligent service as the goal, to the intelligent building electrical small pilot based, fully grasp the power demand side management requirements of intelligent, advanced metering infrastructure for smart grid (AMI) based on the research, the sensing, control, information and network technology, extensive integration of IOT, cloud computing, the modern service concept, to provide intelligent electricity services and social value-added service to the clients.%智能用电服务平台以业务应用和智能服务为目标,以智能用电小区试点建设为依托,充分把握智能化电力需求侧管理的要求,基于面向智能电网的高级计量架构(AMI)的研究,采用传感测量、智能控制、信息网络技术,广泛融合物联网、云计算、现代服务等理念,为客户提供智能用电服务和社会增值服务。

  12. Evaluation of convection-permitting model simulations of cloud populations associated with the Madden-Julian Oscillation using data collected during the AMIE/DYNAMO field campaign

    Energy Technology Data Exchange (ETDEWEB)

    Hagos, Samson M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Feng, Zhe [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Burleyson, Casey D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lim, Kyo-Sun [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Long, Charles N. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wu, Di [NASA Goddard Space Flight Center (GSFC), Greenbelt, MD (United States); Science Systems and Applications, Inc., Lanham, MD (United States); Thompson, Gregory [National Center for Atmospheric Research, Boulder, CO (United States)

    2014-11-12

    Regional cloud permitting model simulations of cloud populations observed during the 2011 ARM Madden Julian Oscillation Investigation Experiment/ Dynamics of Madden-Julian Experiment (AMIE/DYNAMO) field campaign are evaluated against radar and ship-based measurements. Sensitivity of model simulated surface rain rate statistics to parameters and parameterization of hydrometeor sizes in five commonly used WRF microphysics schemes are examined. It is shown that at 2 km grid spacing, the model generally overestimates rain rate from large and deep convective cores. Sensitivity runs involving variation of parameters that affect rain drop or ice particle size distribution (more aggressive break-up process etc) generally reduce the bias in rain-rate and boundary layer temperature statistics as the smaller particles become more vulnerable to evaporation. Furthermore significant improvement in the convective rain-rate statistics is observed when the horizontal grid-spacing is reduced to 1 km and 0.5 km, while it is worsened when run at 4 km grid spacing as increased turbulence enhances evaporation. The results suggest modulation of evaporation processes, through parameterization of turbulent mixing and break-up of hydrometeors may provide a potential avenue for correcting cloud statistics and associated boundary layer temperature biases in regional and global cloud permitting model simulations.

  13. Development and validation of an instrument to assess patients' appraisal, emotions and action tendencies preceding care-seeking in acute myocardial infarction: The PA-AMI questionnaire.

    Science.gov (United States)

    Nymark, C; Saboonchi, F; Mattiasson, A-C; Henriksson, P; Kiessling, A

    2017-03-01

    Reducing patient delay for patients afflicted by an acute myocardial infarction is a task of great complexity, which might be alleviated if more factors that influence this delay could be identified. Although a number of self-reported instruments associated with patient delay exist, none of these taps the content of the appraisal process related to patients' subjective emotions. The aim of this study was to develop and validate a questionnaire aimed at assessing patients' appraisal, emotions and action tendencies when afflicted by an acute myocardial infarction. An item pool was generated based on themes conceptualized in a recent qualitative study of acute myocardial infarction patients' thoughts, feelings and actions preceding the decision to seek medical care. The 'Think-Aloud Protocol' and test-retest analysis at item level were performed. The modified item pool was administered to 96 patients when treated for acute myocardial infarction. Explorative factor analysis and principal component analysis with the non-linear iterative partial least squares algorithm were performed to examine the underlying factor structure of the items. The findings indicated three core dimensions corresponding to three subscales, namely, 'symptom appraisal'; 'perceived inability to act'; 'autonomy preservation'. The results demonstrated acceptable measures of reliability and validity Conclusions: The PA-AMI questionnaire demonstrated satisfactory psychometric properties. Assessment of the included core dimensions may contribute to greater understanding of the appraisal processes for patients afflicted by an acute myocardial infarction.

  14. Influência do conteúdo vaginal de gestantes sobre a recuperação do estreptococo do grupo B nos meios de transporte Stuart e Amies Influence of vaginal environment of pregnant women on the recovery of group B streptococcus in Stuart and Amies transport media

    Directory of Open Access Journals (Sweden)

    José Antonio Simões

    2005-11-01

    Full Text Available OBJETIVO: avaliar a influência do meio vaginal de gestantes na sobrevivência do estreptococo do grupo B (EGB mantido por 8, 24 e 48 horas nos meios de transporte Amies e Stuart. MÉTODOS: foram coletados três swabs vaginais de 30 gestantes atendidas no Ambulatório de Pré-Natal do Centro de Atenção Integral à Saúde da Mulher (CAISM, Universidade Estadual de Campinas (UNICAMP. O primeiro swab foi mergulhado diretamente no meio seletivo de Todd-Hewitt; o segundo foi utilizado para a realização da bacterioscopia corada pelo Gram e o terceiro foi mergulhado em 2 mL de solução salina à qual foram acrescentados 200 µL de uma suspensão contendo EGB na concentração de 1-2 x 10(8 unidades formadoras de colônia. Desta última suspensão de EGB, foram colhidos três swabs do meio Amies e três do meio Stuart, os quais foram mantidos em temperatura ambiente por 8, 24 e 48 horas, para posterior semeadura em ágar sangue. A leitura do crescimento das placas foi realizada após 24 horas de incubação e classificada semiquantitativamente (0-3 cruzes de acordo com o número de colônias observadas. A análise estatística foi efetuada com o teste exato de Fisher. RESULTADOS: a recuperação do EGB nos meios de transporte Amies e Stuart após 48 horas de estocagem foi de 97 e 87%, respectivamente. Em um dos quatro casos em que não houve a recuperação do EGB após 48 horas de armazenamento, o pH vaginal foi superior a 4,5 e em dois casos havia a presença de vaginose citolítica. CONCLUSÕES: ambos os meios de transporte mostraram-se adequados para a recuperação do EGB em gestantes até 48 horas após a coleta. As características do meio vaginal não influenciaram a recuperação do EGB no presente estudo.PURPOSE: to evaluate the influence of vaginal environment of pregnant women on group B streptococcus (GBS survival after 8, 24 e 48 h in Amies and Stuart transport media. METHODS: Three vaginal samples were collected from 30 pregnant

  15. Reference scheme of Chinese program for AMI cardiac rehabilitation%中国心肌梗死康复程序参考方案(第三版试行稿)

    Institute of Scientific and Technical Information of China (English)

    中国康复医学会心血管病专业委员会; 《心血管康复医学杂志》编辑委员会

    2003-01-01

    @@ 目录 前言…………………………………………(542) 第一章急性心肌梗死(AMI)康复的意义和机制……………………………………………(542) 一、AMI康复的意义……………………(542)

  16. Amy Winehouse e a casa dos mortos: a noção de genialidade no Romantismo Alemão DOI - 10.5752/P.2358-3428.2012v16n31p97

    Directory of Open Access Journals (Sweden)

    Sérgio Murilo Rodrigues

    2012-12-01

    Full Text Available  Criar significa destruir também. A genialidade cobra um preço alto: a angústia, a vida dilacerada. A chama que ilumina mais, dura menos. Amy Winehouse não foi a primeira e provavelmente não será a última artista genial a entrar em um processo autodestrutivo. Um processo de total perda de esperança resultando na busca deliberada pela morte. No Romantismo Alemão vários escritores e filósofos falaram sobre o peso da genialidade. Schelling coloca que o gênio é capaz da mesma intuição criadora do Espírito Absoluto. Schopenhauer nos fala da dor de ser gênio. Nietzsche, como Schiller, defende a genialidade artística como o único objetivo digno da vida humana. A vida é arte e cabe a nós desenvolvermos essa arte. Os poetas malditos, as estrelas do rock e do jazz celebraram esta festa, a vida, mesmo que, ao final, não haja mais vida alguma. Diante de um fenômeno midiático como Amy Winehouse, como podemos compreender toda essa reflexão filosófica sobre arte, vida, genialidade e morte?  Palvras-chave: Filosofia. Amy Winehouse. Genialidade. Romantismo Alemão.

  17. Baseline NT-proBNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction: insights from the APEX-AMI trial.

    Science.gov (United States)

    van Diepen, Sean; Roe, Matthew T; Lopes, Renato D; Stebbins, Amanda; James, Stefan; Newby, L Kristin; Moliterno, David J; Neumann, Franz-Josef; Ezekowitz, Justin A; Mahaffey, Kenneth W; Hochman, Judith S; Hamm, Christian W; Armstrong, Paul W; Theroux, Pierre; Granger, Christopher B

    2012-07-01

    Coronary plaque rupture is associated with a systemic inflammatory response. The relationship between baseline N-terminal pro B-type natriuretic peptide (NT-proBNP), a prognostic marker in patients with acute coronary syndromes, and systemic inflammatory mediators in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) is not well described. Of 5,745 STEMI patients treated with primary PCI in the APEX-AMI trial, we evaluated the relationship between baseline NT-proBNP levels and baseline levels of inflammatory markers and markers of myonecrosis in a subset of 772 who were enrolled in a biomarker substudy. Spearman correlations (r (s)) were calculated between baseline NT-proBNP levels and a panel of ten systemic inflammatory biomarkers. Interleukin (IL)-6, a pro-inflammatory cytokine, was significantly positively correlated with NT-proBNP (r (s) = 0.317, P < 0.001). In a sensitivity analysis excluding all heart failure patients, the correlation between baseline IL-6 and NT-proBNP remained significant (n = 651, r (s) = 0.296, P < 0.001). A positive association was also observed with high sensitivity C-reactive protein (r (s) = 0.377, P < 0.001) and there was a weak negative correlation with the anti-inflammatory cytokine IL-10 (r (s) = -0.109, P = 0.003). No other significant correlations were observed among the other testes inflammatory cytokines and chemokines. In STEMI patients undergoing primary PCI, the pro-inflammatory cytokine IL-6 was modestly correlated with baseline NT-proBNP levels. This relationship remained significant in patients without heart failure. This finding is consistent with pre-clinical and clinical research suggesting that systemic inflammation may influence NT-proBNP expression independently of myocardial stretch.

  18. Variations in the polar cap area during intervals of substorm activity on 20-21 March 1990 deduced from AMIE convection patterns

    Directory of Open Access Journals (Sweden)

    J. R. Taylor

    Full Text Available The dynamic behaviour of the northern polar cap area is studied employing Northern Hemisphere electric potential patterns derived by the Assimilative Mapping of Ionospheric Electrodynamics (AMIE procedure. The rate of change in area of the polar cap, which can be defined as the region of magnetospheric field lines open to the interplanetary magnetic field (IMF, has been calculated during two intervals when the IMF had an approximately constant southward component (1100–2200 UT, 20 March 1990 and 1300–2100 UT, 21 March 1990. The estimates of the polar cap area are based on the approximation of the polar cap boundary by the flow reversal boundary. The change in the polar cap area is then compared to the predicted expansion rate based on a simple application of Faraday's Law. Furthermore, timings of magnetospheric substorms are also related to changes in the polar cap area. Once the convection electric field reconfigures following a southward turning of the IMF, the growth rate of the observed polar cap boundary is consistent with that predicted by Faraday's Law. A delay of typically 20 min to 50 min is observed between a substorm expansion phase onset and a reduction in the polar cap area. Such a delay is consistent with a synthesis between the near Earth neutral line and current disruption models of magnetospheric substorms in which the dipolarisation in the magnetotail may act as a trigger for reconnection. These delays may represent a propagation time between near geosynchronous orbit dipolarisation and subsequent reconnection further down tail. We estimate, from these delays, that the neutral X line occurs between ~35RE and ~75RE downstream in the tail.

  19. Un ami qui est toujours

    Institute of Scientific and Technical Information of China (English)

    王艳

    2012-01-01

    Un jour,pendant la récréation,je suis descendue dans le bureau du secrétariat.Quand je préparais un café,une femme professeur d'espagnol s'est exclamée:《Tiens! Tu es de bonne humeur ce matin ! 》 (E)tonnée,je lui ai demandé pourquoi.Elle a répondu:《 Parce que tu prends un ca fé.》Quelle réponse inattendue! Ce n'est qu'un café instantané,un peu fade,pas très bon,à dire vrai.Si j'en prends une petite tasse,ce n'est pas que je suis de bonne humeur.C'est plut(o)t mon habitude,ou bien c'est que le café me donne une belle humeur.

  20. L'ami Magritte (Frans)

    NARCIS (Netherlands)

    Torczyner, H.

    2001-01-01

    Rene Magritte ne conservait pas de copie de ses propres lettres ni en regle generale de celles qu'il recevait en reponse. Dans le cas present toutefois le lecteur decouvrira une correspondance complete et pleine de vie de Magritte accompagnee de lettres ou de commentaires de Harry Torczyner qui four

  1. Design of smart meter based on AMI and DSP & ZigBee%基于AMI并采用DSP和ZigBee的智能电表的设计

    Institute of Scientific and Technical Information of China (English)

    唐旸; 杨冠鲁; 罗钧铃

    2012-01-01

    Smart meters play an important role in the gordian technique of the advanced metering Infrastructure (AMI).To achieve the goal of saving energy by electric information , a smart meter that meeting the demand of AMI was designed. Besides the function of accurately measuring, the smart meter can also make the indoor electricity network being an organic whole, which made the interacting communication and the indoor appliances control come true. In this system, the microcontroller of DSP TMS320F5402 was adopt as the central control unit, the high-precision measurement chip was used as the measurement platform, in addition, the ZigBee wireless communication technology and the external circuit were adopt, making the system become a smart client side network.Primary test indicated that this smart meter measure accurately , make power distribution automatic and the energy consumption interactive%智能电表在高级量测体系(AMI)的关键技术中占据着重要的地位。为使智能电表在精确计量电能的同时,使户内用电网络形成一个有机整体,实现双向通信和户内家电的控制,从而达到信息节能的目的,本文设计了一种能满足AMI系统需要的智能电表。介绍了智能电表的总体设计,采用DSP TMS320F5402的微控制器作中央控制单元,以高精度计量芯片作为测量平台,并配合ZigBee无线通信和外围电路实现对智能用户端的整体构建。实验表明,该表计量准确,实现了配电自动化,用电互动的要求。

  2. 基于SVM的AMI环境下用电异常检测研究%SVM Based Energy Consumption Abnormality Detection in AMI System

    Institute of Scientific and Technical Information of China (English)

    简富俊; 曹敏; 王磊; 孙中伟; 张建伟; 王洪亮

    2014-01-01

    Electrical power system is facing serious security problems due to Advanced Metering Infrastructure(AMI) system which introduces a lot of new technologies in traditional electrical power system. As a result of smart grid, the contradiction of openness and security is increased which will give rise to the increase of electricity fraud. How to detect electricity fraud has become a new issue of grid informatization. On the basis of the AMI’s architecture, the paper adopts One-class SVM technique to detect the abnormal behavior of electricity users which works at a non-supervision Machine learning mode and can get a high accuracy of detection in small sample or unbalanced classification environment. In order to reduce the false alarm rate of the system, the system uses filtering method to handle the test results of SVM classification processing. System can improve the efficiency of electrical inspection and reduce the Non-Technical Losses(NTL) of power system. The paper also gives an implementation of the system which verifies execution efficiency and detection efficiency of the algorithm by real example.%高级测量体系的建设在传统电力系统中引入了许多新技术,对电力系统安全提出了新的考验。网络的开放性和安全性之间的矛盾加大,使得非法电力用户窃电的手段增多,如何有效检测窃电成为电网信息化的一个新问题。根据高级测量体系系统架构的特点,使用One-class SVM无监督机器学习架构对电力用户负荷异常进行检测,可以在小样本、样本分类不均衡环境下提高检测的准确性。使用对检测结果过滤的方法对检测结果进行分类处理,降低系统的虚警率。系统能提高用电稽查效率,降低电力系统的非技术性损失。最后对系统进行架构搭建实现,使用真实算例验证了算法的执行效率和检测效率。

  3. HPV Typing and Expression of hMLH1 and hMSH2 in Bowen Disease%鲍温病HPV分型和hMLH1,hMSH2蛋白的检测

    Institute of Scientific and Technical Information of China (English)

    张跃; 袁伟; 贾常莎

    2014-01-01

    目的 探讨人乳头瘤病毒感染与不同部位鲍温病(Bowen)病发病的关系并检测肿瘤错配修复基因hM-LH1,hMSH2蛋白在Bowen病中的表达情况.方法 20例Bowen病组织来源于2004-2011年皮肤科病理证实标本,其中肛周和外生殖器共3例,其他部位共17例,另取10例正常皮肤为对照.采用人乳头瘤病毒核酸扩增分型方法对Bowen病皮损进行基因分型检测.免疫组化法检测Bowen病组织及10例正常皮肤组织中hMLH1,hMSH2蛋白的表达.结果 20例Bowen病患者中肛周和外生殖器、其他部位共检出6例HPV阳性(30.00%),为HPV16,HPV18,HPV33型.Bowen病组织中hMLH1,hMSH2蛋白阳性表达较正常皮肤组织降低,差异有统计学意义(P< 0.05);Bowen病高危型HPV感染组中hM-LH1,hMSH2蛋白阳性表达低于非感染组(P<0.05).结论 Bowen病的发生可能与HPV感染有关,Bowen病患者皮损中hMLH1,hMSH2蛋白低表达也许与其进展为肿瘤有关联.

  4. 兰州大尾羊血清淀粉酶酯酶及苹果酸脱氢酶同工酶的研究%Study on polymorphism of amylase (Amy), arylesterase (Es), and malate dehydrogenase (MDH) in Lanzhou fat-tailed sheep

    Institute of Scientific and Technical Information of China (English)

    马海明; 门正明; 韩建林

    2002-01-01

    采用聚丙烯酰胺凝胶水平板电泳,对131只兰州大尾羊的血清淀粉酶(Amy)、酯酶(Es)和苹果酸脱氢酶(MHD)的多态性进行检测和分析.结果发现,Amy2基因座2个等位基因Amy2A和Amy2O的基因频率分别为0.166 4和0.833 6,3种基因型Amy2AA*、Amy2AO和Amy2OO的频率分别为0.007 7、0.277 6和0.694 7;Es基因座2个等位基因Es+和Es-的基因频率分别为0.409 4和0.590 6,3种基因型Es++、Es+–、Es––的频率分别为0.169 6、0.483 6和0.348 8;MDH基因座2个等位基因MDSF和MDHS的频率分别为0.264 8和0.735 2,3种基因型FF、FS和SS的频率分别为0.142 9、0.207 7和0.649 4.

  5. Análise de sensibilidade dos métodos de estimativa da evapotranspiração de referência e razão de Bowen em cultura da cana-de-açúcar Sensitivity analysis of methods for estimating reference evapotranspiration and sugarcane evapotranspiration

    Directory of Open Access Journals (Sweden)

    Bruce K. N Silva

    2011-10-01

    Full Text Available A técnica de análise de sensibilidade de modelos foi aplicada nos dados obtidos em experimento de campo conduzido no ano de 2009, na Destilaria Miriri, localizada no município de Capim, PB, e aos dados de evapotranspiração de referência (ETo, obtidos pela equação de Penman-Monteith (FAO/56, e da evapotranspiração da cultura da cana-de-açúcar (ETc, obtidos pelo balanço de energia com base na razão de Bowen. As análises de sensibilidade e de erros foram aplicadas ao método da razão de Bowen para os intervalos de medição de 15, 30, 60 e 120 minutos enquanto o método de Penman-Monteith foi aplicado para a escala diária durante o ano de 2009. Os resultados evidenciam que o saldo de radiação é a variável mais sensitiva no cálculo do balanço de energia, enquanto o fluxo de calor no solo oferece a menor contribuição; já os erros relativos de todas as variáveis envolvidas do cálculo balanço de energia baseado na razão de Bowen aumentaram significativamente com o aumento do intervalo de amostragem. A variável mais sensível na determinação da ETo pelo método de Penman-Monteith é o saldo de radiação seguida da umidade relativa, velocidade do vento a 2m de altura e a temperatura média do ar.The sensitivity analysis technique of models was applied to the data obtained from field experiment carried out during 2009 at Distillery Miriri, Capim, PB. This technique was applied to the reference evapotranspiration (ETo by Penman-Monteith (FAO/56 and the sugarcane evapotranspiration (ETc by energy balance equation based on Bowen ratio. The sensitivity analysis and errors were applied to the Bowen ratio method in measurement intervals of 15, 30, 60 and 120 min; however Penman-Monteith approach was applied on daily basis throughout the 2009 year. Results showed that the net radiation is the most sensitive variable in the energy equation balance and soil heat flux offers the lowest contribution. On the other hand, the relative

  6. 退出江湖 Bruce Bowen

    Institute of Scientific and Technical Information of China (English)

    Husky

    2009-01-01

    这几年来在球员与球迷之间饱受批评的鲍文,终于宣布退休高挂球鞋。这个消息一出,包括布莱恩特(Kobe Bryant)、纳什(Steve Nash)等知名后卫球员,心情上大概都不会觉得太惋惜,其实连鲍文自己都说:"我相信不少人都感到很高兴。"

  7. Foundation on Economic Trends v. Bowen.

    Science.gov (United States)

    1989-10-04

    The National Enviromental Policy Act requires that government agencies make a detailed enviromental impact statement (EIS) for all research significantly affecting the environment. These statements must be supplemented if the project substantially changes or if new information is obtained. The Foundation on Economic Trends argued that three developments in recombinant DNA research will significantly alter the enviromental impact, thereby mandating a new EIS by the National Institutes of Health (NIH). These developments are cloning oncogenic viruses, engineering the human immunodeficiency virus into cells not normally susceptible to it, and introducing AIDS genetic codes into mice. The U.S. District Court, District of Columbia, held that the first two projects do not pose a greater risk and that the enviromental assessment being prepared by NIH on the third satisfies the requirements of the National Enviromental Policy Act.

  8. Genetics Home Reference: Bowen-Conradi syndrome

    Science.gov (United States)

    ... Wiechert J, Cattini PA, Koetter P, Wrogemann K, Greenberg CR, Entian KD, Zelinski T, Triggs-Raine B. ... Frappier D, Innes AM, Lemire EG, Lowry RB, Greenberg CR, Triggs-Raine BL, Morgan K, Wrogemann K, ...

  9. Élaboration d’indicateurs pour l’évaluation des collectivités-amies des aînés au Canada : démarche et résultats

    Directory of Open Access Journals (Sweden)

    H. Orpana

    2016-01-01

    Full Text Available Introduction : En 2006, l’Organisation mondiale de la Santé (OMS a lancé le projet mondial « Villes-amies des aînés » afin de favoriser un vieillissement actif. Si un grand nombre d’initiatives « amies des aînés » ont été mises en oeuvre au Canada, on dispose de peu d’information sur l’efficacité et les résultats des initiatives des collectivités-amies des aînés (CAA. En outre, les intervenants affirment qu’ils n’ont pas la capacité et les outils nécessaires pour élaborer et réaliser des évaluations relatives à leurs initiatives de CAA. Afin de pallier ces lacunes, l’Agence de la santé publique du Canada a mis au point des indicateurs pour l’évaluation des initiatives de CAA dans de nombreuses collectivités canadiennes. Ces indicateurs, destinés à répondre aux différents besoins des collectivités, ne sont pas conçus pour faire l’évaluation de répercussions collectives ou pour rendre possible une comparaison entre collectivités. Méthodologie : Une démarche de consultation itérative fondée sur des données probantes a été employée pour l’élaboration d’indicateurs relatifs aux CAA. Elle a nécessité une revue de la littérature et une analyse du contexte. Deux rondes de consultation auprès d’experts et d’intervenants clés ont été menées, ce qui a permis de classer les indicateurs potentiels en fonction de leur importance, de leur capacité à être mis en pratique et de leur faisabilité. Une liste définitive d’indicateurs et de mesures potentielles a ensuite été mise au point, en fonction des résultats de ces consultations et de considérations clés relatives aux politiques. Résultats : Trente-neuf indicateurs répartis en huit domaines relevant des CAA et quatre indicateurs relevant des résultats liés à la santé et aux conditions sociales à long terme ont été sélectionnés. Tous sont conformes à l’objectif énoncé, à savoir l’évaluation des

  10. 从读者接受理论解析谭恩美作品之意象翻译%Image Translation Analysis of Amy Tan's Works from the Perspective of Readers Reception Theory

    Institute of Scientific and Technical Information of China (English)

    田园

    2011-01-01

    Readers reception theory stresses that the significance of works can only be generated in the process of reading and any text would have different meanings in the process of consumption and self-realization. Only when readers' expected visions have common points with the texts, reception and understanding could be initially achieved. Amy Tan's works are one of the represent- atives for Chinese-American literature and the creation specialty will surely lead to understanding deviation for Chinese readers. An initial analysis is made from the angle of readers reception theory for the translation of "mother" and "food"- the two major images in Amy Tan's works, with the expectation of achieving satisfying reader effect.%读者接受理论强调作品的意义只有在阅读过程中才能产生,任何文本在其自身被消费、被自我实现的过程中都会有不同的意义。只有读者的期待视野与文学文本相融合,才谈得上接受和理解。谭恩美作品是海外华文文学的代表之一,其创作的特殊性必定会使中国读者在作品理解上产生偏差。尝试从读者接受理论的视角出发,分析谭恩美作品的两大意象——“母亲”与“食物”的翻译,期望能获得满意的读者效果。

  11. 音乐在PCI术后早期急性心肌梗死患者中的应用%Effects of Music on Early Period of Post-PCI of AMI Patients

    Institute of Scientific and Technical Information of China (English)

    杨黎; 黄惠根; 吴兰笛; 周英; 王娇艳

    2012-01-01

    目的:探讨音乐应用于PCI术后早期急性心肌梗死患者的作用,促进患者康复.方法:便利抽样100名PCI术后AMI患者,分对照组和音乐组各50例,采用《HAD》和《AIS》调查并记录患者实验前后血压、心率、呼吸.结果:音乐组患者焦虑、睡眠质量、血压、心率、呼吸得分差值下降多于对照组,但抑郁得分较对照组高(P<0.05).结论:音乐可缓解患者的焦虑,提高睡眠质量,维持血压、心率、呼吸处于相对较低水平.但音乐可释放抑郁情绪,应注意心理护理.%Objective , The purpose of this study was to find out the effects of Music on early period of post-PCI of AMI patients. Method ,100 participants took part in the experiment. They divided into the mached group (n=50) and experiment group (n=50). HADSAIS^BP^HR and BR were recorded before and after the experiment. Results, The participants in the experiment group's anxiety Nsleep quality ,BP,HR and BR all decreased more than the mached group' s, However the depression score was higher than the mached group's (P<0.05. Conclusion, Music can significant release the anxiety, improve sleep quality, lower BP,HR and BR of AMI patients.

  12. Relationship between TNF-α and ventricular arrhythmias in acute myocardial infarction(AMI)%急性心肌梗死时肿瘤坏死因子-α表达与室性心律失常的关系

    Institute of Scientific and Technical Information of China (English)

    肖华; 陈志坚; 廖玉华; 程翔; 刘坤; 王敏

    2008-01-01

    胞内钙短时间内大量增加有关.%Objective To investigate the relatonahip between TNF-α and ventricular arrhythmias after acute myocardial infarction(AMI)and its mechanism.Method Both the clinical and animal experiments were done.(1)Clinical experiment:Eighty patients with AMI were included in Union Hospital,Tongji Medical College,Huazhong University of Science and Techology,from May 2005 to November 2006 according to the WHO diagnostic criteria.Co-infection of diseases such as severe upper respiratory infection,lung infection,high fever,cancer,et al were excluded.The relationship between the levels of TNF-α and arrhythmias were observed at different times after AMI.A straight line correlation,analysis Was done.(2)Animal experiment:Different concentrations of TNF-αwere added to isohted rat hearts for observing the arrhythrnia effects.The effect of TNF-α on intracellular Ca2+ concentration was detected by laser confocal technique.All data were analyzed by SNK-q test using SPSS 13.0 sofeware prograrn.Results(1)The plasma levels of TNF-α were significantly associated with the Lown class of PVC after AMI and they were higher in AMI of anterior wall[(46.41±10.34)pg/ml]than other positions [(28.25±6.35)pg/ml,P<0.05].2)The frequency of ventricular arrhythmias was interrelated with the concentralions of TNF-α.Using etanercept beforehand,TNF-α induced a slight increase of intracellular Ca2+ intensity (P<0.05).Conclusions There was a relationship between TNF-αlevels and ventricular arrhythmisa in patients with AMI.Animal experiments confirmed the isolated heart perfusion with TNF-α induced ventricular arrhytrnias.Expression of TNF-α after AMI was related with the occurrence of ventricular arrhythrnias.The effect might be associated with the increased inuaeellular Ca2+ intensity caused by TNF-α.

  13. 循证护理用于急性心肌梗死患者的效果评价%The Effective Evaluation on Evidence-based Nursing to AMI Patients

    Institute of Scientific and Technical Information of China (English)

    牛芳荣; 李丽; 唐丹; 武晓红; 王庆芬

    2015-01-01

    目的:探讨循证护理在急性心肌梗死患者中的应用效果。方法:将50例急性心肌梗死患者随机分为观察组和对照组各25例。对照组实施常规护理,观察组给予循证护理。观察2组护理前后心理健康(Zung焦虑自评量表-SAS和Zung抑郁自评量表-SDS)和生活质量(采用SF-36量表评定情感指数、健康指数和生活满意度)变化。结果:护理后SAS、SDS评分观察组分别为(36.92±5.24)分、(41.72±4.13)分,对照组分别为(41.54±3.73)分、(45.63±4.59)分,观察组均明显低于对照组(P<0.05)。护理后情感指数、健康指数和生活满意度观察组分别为(8.56±1.89)分、(10.64±3.71)分、(9.88±2.11)分,对照组分别为(7.17±1.66)分、(8.25±2.03)分、(8.33±1.66)分,观察组均高于对照组(P<0.05)。结论:循证护理能明显改善急性心肌梗死患者的焦虑、抑郁状态,提高生活质量。%Objective:To discuss the application of evidence-based nursing for acute myocardial infarction (A-MI) patients. Methods:The 50 AMI patients were randomize into 25 cases of observation and control groups. The cases in the observation group were implemented the conventional nursing while the control group given evi-dence-based nursing. The psychological health (assessed by SAS and SDS) and life quality (valued the emotional and healthy indexes as well as life satisfaction of the patients by SF-36) of both groups before and after nursing were observed. Results:After nursing, the SAS and SDS scores in the observation group were (36.92 ±5.24) and (41.72 ± 4.13) respectively, while those in the control group were (41.54 ±3.73) and (45.63 ±4.59), and the SAS and SDS scores of the observation group were significantly lower than those of the control group (P<0.05). The emotional and healthy indexes as well as life satisfaction of the patients in the observation group were (8.56±1.89), (10.64± 3.71) and (9.88±2

  14. Cloning and Bioinformatic Analysis of Potato α-Amylase Gene amyA1%马铃薯α-淀粉酶基因的克隆及生物信息学分析

    Institute of Scientific and Technical Information of China (English)

    王玉丽; 王永刚; 马建忠; 王倩; 陶鹏飞; 苏移

    2010-01-01

    本研究利用RT-PCR从马铃薯(Solanum tuberosum)茎段总RNA中扩增、克隆了一cDNA分子.该cDNA分子含有一长为1 224 bp的开放读框,可编码一含407个氨基酸残基的多肽、理论分子量为46.40 kD、可能为亲水性的胞外酶.因其氨基酸序列同源于α-淀粉酶,故将该基因命名为amyA1(NCBI收录号:GQ406048.1).采用半定量RT-PCR方法检测了amyA1基因在马铃薯茎、叶等不同组织中的表达强度,表明在茎组织中的表达丰度略高.利用生物信息学软件分析了amyA1密码子的偏好性,以期为选择适宜的表达系统提供依据;同时对amyA1的理化性质、细胞内定位、保守结构及高级结构进行了预测.基于NCBI数据库中有物种代表性的29种α-淀粉酶基因序列构建了基因进化树.与NCBI收录的马铃薯α-淀粉酶基因(NCBI收录号:M79328.1)的核苷酸及氨基酸序列同源性达98%.第20至第348范围内的氨基酸残基含有与淀粉酶13家族及亚家族相似的催化活性域(PF00128、SM00624),第349至第407范围内的氨基酸残基含有α-淀粉酶C-末端β折叠区域(PF07821).蛋白质结构预测表明氨基酸残基序列有维持淀粉酶活性的(β/α)8桶状结构以及其它几个功能域结构.所构建的基因进化树表明,2个马铃薯α-淀粉酶基因与木薯、苹果的序列同源性较高,与菜豆的次之,与水稻、大麦和玉米等单子叶植物的序列同源性较低.

  15. Clinical Significance of Changes of Plasma ET and NPY Levels After Treatment in Patients with AMI%AMI患者治疗前后血浆ET和NPY水平的变化及临床意义

    Institute of Scientific and Technical Information of China (English)

    周金保

    2005-01-01

    目的:探讨了急性心肌梗死(AMI)患者血浆内皮素(ET)、神经肽Y(NPY)水平的变化.方法:应用放射免疫分析对36例急性心肌梗死患者进行了血浆ET、NPY测定,并与35名正常健康人作比较.结果:急性心肌梗死患者治疗前血浆ET、NPY水平显著地高于正常人组水平(P<0.01),治疗后一个月仍高于正常组水平(P<0.05).结论:测定急性心肌梗死患者血浆ET、NPY水平对观察病情和预后判定具有重要的临床价值.

  16. Spectral state dependence of the 0.4-2 MeV polarized emission in Cygnus X-1 seen with INTEGRAL/IBIS, and links with the AMI radio data

    CERN Document Server

    Rodriguez, J; Laurent, P; Bel, M Cadolle; Pottschmidt, K; Pooley, G; Bodaghee, A; Wilms, J; Gouiffès, C

    2015-01-01

    Polarization of the >~400 keV hard tail of the microquasar Cygnus X-1 has been independently reported by INTEGRAL/IBIS, and INTEGRAL/SPI and interpreted as emission from a compact jet. These conclusions were, however, based on the accumulation of all INTEGRAL data regardless of the spectral state. We utilize additional INTEGRAL exposure accumulated until December 2012, and include the AMI/Ryle (15 GHz) radio data in our study. We separate the observations into hard, soft, and intermediate/transitional states and detect radio emission from a compact jet in hard and intermediate states, but not in the soft. The 10-400 keV INTEGRAL (JEM-X and IBIS) state resolved spectra are well modeled with thermal Comptonization and reflection components. We detect a hard tail in the 0.4-2 MeV range for the hard state only. We extract the state dependent polarigrams of Cyg X-1, which all are compatible to no or undetectable level of polarization except in 400-2000 keV range in the hard state where the polarization fraction is...

  17. 运用探究式 学习比较级——New Standard English Book 4(三年级起始)(新标准英语第四册)Module 5 Size Unit 1 Amy's taller than Lingling课堂教学实录与评析

    Institute of Scientific and Technical Information of China (English)

    崔秀利; 肖娜

    2007-01-01

    @@ Function (功能): Talking about comparisons. Teaching points (重点): 1. The comparative degree of adjective. 2. Vocabulary: old young than strong 3. Sentences: Amy's taller than Lingling. 4. Using adjectives with regular comparative to make comparison. Teaching aids(教具):CAI,tape recorder Teacher(教师):Xiao Na,from Erhulai School Students(学生):Class2,Grade4

  18. Effects of intra-aortic balloon pump combined with emergency PCI in AMI patients complicated cardiogenic shock%急诊PCI联合主动脉内球囊反搏对急性心肌梗死合并心源性休克的疗效

    Institute of Scientific and Technical Information of China (English)

    李建伟; 王曼; 谢芳元; 董昕

    2012-01-01

    Objective: To study clinical efficacy of intra- aortic balloon pump (IABP) combined with emergency percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) complicated cardiogenic shock. Methods: Clinical data of 16 AMI complicated cardiogenic shock patients undergoing PCI combined with IABP were retrospectively studied. Results: All patients successfully underwent IABP and PCI. IABP duration was 20~190 (70. 6+ 37. 2) h. Bleeding of local puncture sites occurred in three cases (18. 75%) and they were stopped after compression. One case (6.25%) died during admission and there were no other severe complications besides one case death. Conclusion: Intra - aortic balloon pump combined with percutaneous coronary intervention is safe and effective in AMI patients with cardiogenic shock.%目的:探讨经皮冠状动脉介入治疗(PCI)联合主动脉球囊反搏术(IABP)治疗急性心肌梗死(AMI)心源性休克患者的临床疗效.方法:回顾性分析16例联合IABP行PCI治疗的AMI合并心源性休克患者的临床资料.结果:16例患者均成功置入IABP及行PCI术,IABP使用时间20~190 (70.6±37.2)h,3例(18.75%)出现局部穿刺部位出血,经压迫后出血停止,除住院期间死亡1例(6.25%),无重大并发症.结论:对于心源性休克患者,联合主动脉球囊反搏术行经皮冠状动脉介入治疗安全、有效.

  19. Clinical Analysis and Coronary Angiographic of Young Patients with AMI%青年急性心肌梗死患者的临床及冠状动脉造影病变特点的分析

    Institute of Scientific and Technical Information of China (English)

    李丹; 林海龙; 顾宇; 颜培实

    2013-01-01

    目的:分析青年急性心肌梗死患者的临床及冠状动脉造影病变特点的分析。方法将2011年9月至2013年8月我院的136例急性心肌梗死患者,按年龄分为青年组50例(<50岁)和老年组86例(50~79岁)。分别比较两组患者的临床特征,冠状动脉造影特点及心功能变化。结果青年组及老年组中高血压、糖尿病、吸烟等分别占10%、10%、92%;72.1%、42%、85%。青年组中男性患者较多,低密度脂蛋白高于老年组,冠状动脉造影单支病变多见,多见于前降支(80%),其次是右冠(4%)。老年男性组多支病变多见,住院期间主要心血管不良事件的发生率高于青年组。结论吸烟及高脂血症、高血压等是青年急性心肌梗死的重要危险因素,青年组单支病变多见,冠状动脉介入术后预后好。%Objective To analy the characteristics and coronary angiographic of acute myocardial infarction in the young. Methods 136 AMI cases from September 2011 to August 2013 who were performed percutaneous coronary intervention were divided into 50 cases in the Young and 86 cases in the elderly. Including clinical charactericstics,coronary angiographic and vary of ventuiculer dysfunction. Results The propretional of the hypertension, DM and smoking was respectively 10%, 10%, 92%in adults and 72.1%, 42%, 85%in elder patients. LDL in young patients was higher than elder patients. Young patients were predominantly males incomparision with those in elder patients. Single vessel lesions were common. The left anterior descending arteries (80%) were affected and the second arteries were RCA (4%). The major adverse cardiovascular events were found in elder patients during hospitalization. Conculsion Smoking and hypertension, hyperlipidaemia are the most important risk factors in the young patients with AMI. Young patients are more likely to have single vessel lesions and have a good prognosis.

  20. Prognostic implications of Q waves at presentation in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: An analysis of the HORIZONS-AMI study.

    Science.gov (United States)

    Kosmidou, Ioanna; Redfors, Björn; Crowley, Aaron; Gersh, Bernard; Chen, Shmuel; Dizon, José M; Embacher, Monica; Mehran, Roxana; Ben-Yehuda, Ori; Mintz, Gary S; Stone, Gregg W

    2017-07-11

    Presence of Q waves on the presenting electrocardiogram (ECG) in patients with ST-segment elevation myocardial infarction (STEMI) has been associated with worse prognosis; however, whether the prognostic value of Q waves is influenced by baseline characteristics and/or rapidity of revascularization based on the guideline-based metric of door-to-balloon time remains unknown. We hypothesized that Q waves in the presenting ECG will be predictive of long term mortality regardless of time to reperfusion. The Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial enrolled 3602 patients with STEMI undergoing primary percutaneous coronary intervention. We stratified patients without prior history of myocardial infarction or coronary revascularization according to presence or absence of pathological Q waves on their presenting ECG. Associations between Q waves, death, and cardiovascular outcomes within 3 years were assessed using Cox proportional hazards regression. Among 2723 patients with evaluable ECGs, 1084 (39.8%) had Q waves on their presenting ECG. Male sex and time from symptom onset to balloon inflation were independent predictors of presence of Q waves. Patients with Q waves had higher adjusted risks of all-cause death (adjusted hazard ratio: 1.45, 95% confidence interval: 1.02-2.05, P = 0.04) and cardiac death (adjusted hazard ratio: 1.72, 95% confidence interval: 1.08-2.72, P = 0.02). The association between Q waves and cardiac death was consistent regardless of sex, diabetes status, target vessel, or door-to-balloon time (Pinteraction > 0.4 for all). Presence of Q waves on the presenting ECG in patients undergoing primary percutaneous coronary intervention due to STEMI is an independent predictor of mortality and adds prognostic value, regardless of sex or rapidity of revascularization. © 2017 Wiley Periodicals, Inc.

  1. Hydrographic and Impairment Statistics Database: AMIS

    Data.gov (United States)

    National Park Service, Department of the Interior — Hydrographic and Impairment Statistics (HIS) is a National Park Service (NPS) Water Resources Division (WRD) project established to track certain goals created in...

  2. Le médecin, mon ami?

    OpenAIRE

    Rieder, Philip Alexander

    2014-01-01

    Cet article retrace l'histoire de la relation thérapeutique au cours de l'Ancien Régime en mettant en évidence l'importance de l'amitié entre le médecin et son malade. Une explication est proposée à la transition, au 19e siècle, vers une relation thérapeutique professionnelle.

  3. 21st Century Skylines / Amy Bryzgel

    Index Scriptorium Estoniae

    Bryzgel, Amy

    2008-01-01

    Kumu Kunstimuuseumist Tallinnas (arh. Pekka Vapaavuori), Leedu rahvusliku kunstigalerii renoveerimisest (Vilnius, ehitatud 1968. aastal, arh. Gediminas Baravykas ja Vytautas Vielius), uuest ehitatavast Guggenheim-Ermitaazhi muuseumist Vilniuses (arh. Zaha Hadid), Riia uuest kunstimuuseumist, mis ehitatakse vanasse 1905. a. ehitatud tööstushoonesse. (arh. Rem Koolhaas)

  4. 21st Century Skylines / Amy Bryzgel

    Index Scriptorium Estoniae

    Bryzgel, Amy

    2008-01-01

    Kumu Kunstimuuseumist Tallinnas (arh. Pekka Vapaavuori), Leedu rahvusliku kunstigalerii renoveerimisest (Vilnius, ehitatud 1968. aastal, arh. Gediminas Baravykas ja Vytautas Vielius), uuest ehitatavast Guggenheim-Ermitaazhi muuseumist Vilniuses (arh. Zaha Hadid), Riia uuest kunstimuuseumist, mis ehitatakse vanasse 1905. a. ehitatud tööstushoonesse. (arh. Rem Koolhaas)

  5. AMiBA Wideband Analog Correlator

    CERN Document Server

    Li, Chao-Te; Wilson, Warwick; Lin, Kai-Yang; Chen, Ming-Tang; Ho, P T P; Chen, Chung-Cheng; Han, Chih-Chiang; Oshiro, Peter; Martin-Cocher, Pierre; Chang, Chia-Hao; Chang, Shu-Hao; Altamirano, Pablo; Jiang, Homin; Chiueh, Tzi-Dar; Lien, Chun-Hsien; Wang, Huei; Wei, Ray-Ming; Yang, Chia-Hsiang; Peterson, Jeffrey B; Chang, Su-Wei; Huang, Yau-De; Hwang, Yuh-Jing; Kesteven, Michael; Koch, Patrick; Liu, Guo-Chin; Nishioka, Hiroaki; Umetsu, Keiichi; Wei, Tashun; Wu, Jiun-Huei Proty

    2010-01-01

    A wideband analog correlator has been constructed for the Yuan-Tseh Lee Array for Microwave Background Anisotropy. Lag correlators using analog multipliers provide large bandwidth and moderate frequency resolution. Broadband IF distribution, backend signal processing and control are described. Operating conditions for optimum sensitivity and linearity are discussed. From observations, a large effective bandwidth of around 10 GHz has been shown to provide sufficient sensitivity for detecting cosmic microwave background variations.

  6. G.hnem for AMI and DR

    DEFF Research Database (Denmark)

    Rossello Busquet, Ana

    2012-01-01

    consumption and production. Power Line Communication (PLC) is a candidate technology for connecting the customers and utilities as it is easy to deploy and has extensive coverage. ITU-T G.hnem standard defines a narrowband PLC, which was specially designed for Smart Grid applications. This paper proposes...... a PLC network architecture following the G.hnem standard, which enables bi-directional communication among customers and utilities....

  7. Effect of Recipe of Supplementing Qi and Activating Blood (RSA) on NO3-、ONOO-、MDA、GLU、AMY in Faeces of High Fat Diet Rats%补气活血法对高脂饮食大鼠粪便NO-3 、ONOO- 、MDA、GLU、AMY的影响

    Institute of Scientific and Technical Information of China (English)

    马月梅; 刘晓秋; 张永斌

    2011-01-01

    Objective To investigate the effect of high fat diet on NO3-、 ONOO - ,MDA,glucose,amylase activity. PNA,PSA binding rates af amylase, amylase isoenzyme profile in rat faeces and the effect of recipe of supplementing Qi and activating blood ( RSA )Methods Male rats were randomly divided into four groups: normal group( feeding ordinary diet) ; model group( feeding high fat diet) ;RSA Ⅰ ( feeding RSAI ( S: A =2: 1) by gastrogavage) ; RSA 2 ( feeding RSA2 ( S: A = 1 : 2) by gastrogavage) . N03- , ONOO- , MDA , glucose and amylase activity in rat faeces were determined by colorimetric method. N -glycan patterns of amylase were determined with lectin ( PSA and PNA) affinity precipitation method, and faeces amylase isoenzyme profile was separated by electrophoresis on polyacrylamide gels electrophoresis ( PAGE). Results High fat diet rats showed the symptoms of polyuria, polydipsia, polyphagia and weight loss. These abnormal signs were improved after treatment with RSA. In high fat diet rats, amylase activity, N03 - , P - Amy.S - Amy in faeces were decreased, while PSA, PNA binding rates of amylase, glucose, ONOO - in faeces were increased. After treatment with RSA, all of these indicators were improved. There was difference between RSA1 action and RSA 2 action. Conclusion Supplementing Qi and activating blood method can improve N - glycan deficiency in faeces amylase and up - regulate faeces amylase activity , and increase N03- , also decrease glucose, ONOO- in faeces, thus can regulate the digestion/absorption and glucose metabolism, can reduce oxygen free radicalinduced intestinal damage. This study also showed the different impacts of two different RSA.%目的 研究高脂饮食对大鼠粪便NO3-、ONOO-、MDA、GLU、AMY活性、AMY PSA、PNA结合率、AMY谱的影响,同时研究补气活血中药的作用.方法 雄性SD大鼠随机分为正常组,喂饲普通饲料;模型组,喂饲高脂饲料;补气活血1组(RSA 1),2∶ 1补气

  8. 心型脂肪酸结合蛋白在急性心肌梗死早期诊断中的临床应用%The clinical application of heart-fatty acid binding protein in AMI early diagnosis

    Institute of Scientific and Technical Information of China (English)

    罗俭权; 李竞春; 龙振洪; 徐超成; 江金萍

    2016-01-01

    目的探讨心型脂肪酸结合蛋白(heart-fatty acid binding protein, H-FABP)对早期诊断急性心肌梗死(acute myocardial infarction, AMI)的临床应用价值。方法选取2013年1月至2015年6月我院诊断为AMI的患者151例为AMI组,同期选择有胸痛指征但最终排除AMI诊断的其他疾病患者68例为对照组,检测两组患者发病后0-3 h、3-6 h、6-12 h血清H-FABP、心肌肌钙蛋白I(cardiac tro-ponin I, cTnI)、肌酸激酶(creatine kinase, CK)及肌酸激酶同工酶(MB isoenzyme of creatine kinase, CK-MB)水平,对检测结果进行统计学分析。结果 AMI组0-3 h、3-6 h、6-12 h的H-FABP、cTnI、CK、CK-MB检测水平均显著高于对照组,且差异均具有统计学意义(P均<0.05)。血清H-FABP诊断AMI的灵敏度、特异性及受试者工作特征曲线下面积分别为78.8%、89.7%及0.919,均高于其他三项指标。所有AMI患者中,H-FABP与cTnI、CK及CK-MB在不同时间段的检测结果均有较好的相关性,且相关系数r均>0.8。结论 H-FABP对早期诊断AMI有较好的临床应用价值,优于cTnI、CK及CK-MB。%Objective To investigate the clinical application value of heart-fatty acid binding protein (H-FABP) in acute myocardial infarction(AMI) diagnosis. Methods 151 cases AMI patients in our hospital from January 2013 to June 2015 were collected as the AMI group. 68 cases patients with chest pain indications but obviated AMI during the same period were selected as the control group. The levels of H-FABP , cardiac troponin I(cTnI), creatine kinase(CK) and MB isoenzyme of creatine kinase(CK-MB) at 0-3 h, 3-6 h, 6-12 h of all the patients to fall in disease were detected. The results were analyzed statistically. Results The levels of H-FABP, cTnI, CK and CK-MB at 0-3 h, 3-6 h, 6-12 h in AMI group were all higher than that of control group, and the differences all had statistical significance

  9. Clinical analysis of intra-aortic balloon pump counterpulsation in adjuvant treatment of AMI complicated with cardiogenic shock%主动脉内球囊反搏辅助治疗急性心肌梗死合并心源性休克的临床分析

    Institute of Scientific and Technical Information of China (English)

    崔晓琼; 李彤; 胡晓旻; 张文芳; 刘迎午; 王禹; 张强; 稂与恒

    2011-01-01

    目的 分析主动脉内球囊反搏(IABP)辅助治疗急性心肌梗死合并心源性休克的临床疗效.方法 选择急性心肌梗死合并心源性休克的老年患者50例,观察置入IABP前后患者血流动力学变化、心功能、IABP并发症及预后情况.结果 与IABP置入前比较,患者置入IABP后平均动脉压、心率、LVEF及心功能指标均得到不同程度的改善,无严重并发症出现,预后良好.结论 IABP辅助治疗急性心肌梗死合并心源性休克可能有效安全.%Objective To analyze clinical efficacy of intra-aortic balloon pump(IABP) counterpulsation in adjuvant treatment of patients with acute myocardial infarction(AMI) complicated with cardiogenic shock. Methods Fifty senile patients with AMI complicated with cardiogenic shock were chosen to observe the hemodynamic changes,the cardiac function,the IABP complication and prognosis before and after applying IABP. Results Compared with before applying IABP, hemodynamic parameters such as MAP,HR,LVEF and the cardiac function were improved in varying degrees after applying IABP,no serious complication appeared and prognosis was good. ConclusionIABP for adjuvant treatment of AMI complicated with cardiogenic shock is safe and effective.

  10. 急性心肌梗死给予脑钠肽前体检测对溶栓治疗预后的评价%The Thrombolysis Treatment Prognosis Evaluation about Plasma NT-proBNP in the AMI Patients

    Institute of Scientific and Technical Information of China (English)

    朱自强; 于力

    2014-01-01

    Objective:To observe whether early cardiovascular events occurred in patients with successful thrombolysis to explore the differences of NT-proBNP,and to detect its correlation with serum troponin T,CK,CK-MB,left ventricular ejection fraction,left ventricular end-diastolic volume,and discuss the value of plasma NT-proBNP for severity and prognostic significance in the AMI patients with successful thrombolysis.Method:The plasma NT-proBNP collecting before thrombolytic therapy in 61 patients with AMI was measured by enzyme-lined imunosorbent assay. All patients were followed up for 30 days,the occurrence of cardiovascular death,heart failure,recurrent AMI in 30 days,post-infarction angina,etc were observed. Result:Index of age, gender, height, weight, smoking, hypertension, diabetes and the incidence of myocardial infarction site of two groups had no difference(P>0.05),there were positive correlation between logNT-proBNP level and cTnT, CK, CK-MB,LVEDV(P0.05),logNT-proBNP水平与cTnT、CK、CK-MB、LVEDV存在正相关(P<0.05),与LVEF存在负相关(P<0.05)。结论:测定入院时血浆NT-proBNP水平对评估AMI经过成功溶栓治疗的患者30 d内发生心血管事件有重要的临床价值。

  11. Clinical observation of bedside IABP combined with MV in treatment of 35 elderly AMI patients combined with cardiogenic shock%床边主动脉球囊反搏联合机械通气治疗老年急性心肌梗死合并心源性休克患者35例的临床观察

    Institute of Scientific and Technical Information of China (English)

    陈中俊; 杜叶平; 梁战海; 韩秋

    2012-01-01

    Objective To investigate the clinical effect of bedside intra-aortic balloon pump (IABP) combined with mechanical ventilation (MV) in the treatment of 35 elderly AMI patients combined with cardiogenic shock. Methods 35 cases of elderly AMI patients combined with cardiogenic shock were treated with bedside IABP and MV at the same time. The correct time of cardiogenic shock, MV and IABP removing time, incidence of death and complications, and blood gas analysis index before and after treatment were observed. Results Among 35 patients, 15 cases were dead, the mortality rate was 42.85%. The MAP, HR, PaO2 and PaCO2 of patients after treatment were significantly improved than those of before treatment, the differences were statistically significant (P < 0.01). Conclusion The efficacy of bedside IABP combined with MV in treatment of elderly AMI patients combined with cardiogenic shock is exactly, which should be used as soon as possible.%目的 探讨床边主动脉球囊反搏联合机械通气治疗老年急性心肌梗死并心源性休克的临床疗效.方法 35例老年急性心肌梗死(AMI)合并心源性休克患者在床边行主动脉内球囊反搏(IABP)合并给予机械通气(MV)治疗.观察心源性休克纠正时间、MV撤机时间、IABP撤机时间、死亡及并发症发生情况,并比较治疗前后血气分析指标.结果 本组35例患者死亡15例,病死率为42.85%;治疗前后平均动脉压(MAP)、心率(HR)、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)均有显著改善,差异有高度统计学意义(P < 0.01).结论 床边IABP联合MV治疗老年AMI合并心源性休克疗效确切,应尽早使用.

  12. The Plasma Levels of Brain Natriuretic Peptide (BNP) in Patients With Acute Myocardial Infarction (AMI) Study of the Change%血浆中脑钠素(BNP)在急性心肌梗死(AMI)后的水平变化研究

    Institute of Scientific and Technical Information of China (English)

    祝红娟

    2015-01-01

    ObjectiveTo study the plasma levels of brain natriuretic peptide (BNP) in patients with acute myocardial infarction (AMI) after the change level.Methods the changes of BNP between the two groups comparison between AMI patients and healthy people.Results The observation group patients with 24 h within the plasma levels of BNP was significantly increased compared to the same period, with statistically significant difference between groups (P<0.05). ConclusionThe level of serum BNP in patients with acute myocardial infarction value to make early diagnosis of myocardial infarction with positive value.%目的:研究血浆中脑钠素(BNP)在急性心肌梗死(AMI)后的水平变化情况。方法对比 AMI患者和健康人两组间BNP变化。结果观察组患者24 h之内的BNP血浆水平明显增高,组间差异具有统计学意义(P<0.05)。结论急性心肌梗死患者的血浆BNP值对心肌梗死作出早期诊断具有积极的价值。

  13. 联合检测血清H-FABP、P选择素对急性心肌梗死近期预后的评估%The prognostic value of the combined detection of serum H-FABP and soluble P-selectin on short-term prognosis in patients with acute myocardial infarction(AMI)

    Institute of Scientific and Technical Information of China (English)

    杨溶海; 方长庚; 梁建光

    2014-01-01

    Objective:To evaluate the prognostic value of the combined detection of serum H-FABP and soluble P-selectin on short-term prognosis in patients with acute myocardial infarction ( AMI ) . Methods: 123 patients with acute AMI were categorized into main adverse cardiac events ( MACE) group ( 44 cases) and non-MACE group ( 79 cases) . Then, the concentration of H-FABP and soluble P-selectin were compared between the two groups.Results:The serum H-FABP and soluble P-selectin of group MACE were (68.53±32.57) ng/L and (353.21±88.17) ng/L respectively, which were significantly higher than those of non-MACE group [H-FABP:(47.58±21.56) ng/L;soluble P-selectin:(286.21±76.35) ng/L] (P<0.05).Conclusion:H-FABP and soluble P-selectin may better provide early warning for occurrence of MACE in patients with AMI.%目的:探讨联合检测血清H-FABP、P选择素检测对急性心肌梗死近期预后的评估。方法:将123例急性心肌梗死分成不良心血管事件( MACE )组(44例)和非 MACE 组(79例),比较两组血浆H-FABP、P选择素浓度。结果:MACE 组血清H-FABP为(68.53±32.57) ng/L、P选择素为(353.21±88.17) ng/L,均高于非 MACE 组的(47.58±21.56) ng/L、(286.21±76.35) ng/L(均 P<0.05)。结论:血浆 H-FABP、P选择素对急性心肌梗死患者发生不良心血管事件具有较好的预警作用。

  14. Market Economy, Democratic System, and Ethnic Hatred— introducing World On Fire: How Free Market Democracy Breeds Ethnic Hatred and Global Instability by Amy Chu%市场经济、民主体制和种族仇视 --读《燃烧的世界》

    Institute of Scientific and Technical Information of China (English)

    秦亚青

    2003-01-01

    @@ 西方主流政治学理论认为经济市场化和政治民主化是共生共存的.在过去40年里,这一观点一直占据了理论界的主导地位.美国耶鲁大学华裔法学教授蔡美儿(Amy Chua)刚刚出版的著作却从种族研究的视角,对主流政治学的发展理论提出了挑战.①该书一经出版,立即引起了学界的重视,并且引发了不小的争论.

  15. The value of myocardium enzyme and APACHE Ⅱ score in the prognosis of ICU patients without AMI%心肌酶与APACHE Ⅱ评分在ICU非心肌梗死患者预后中的价值

    Institute of Scientific and Technical Information of China (English)

    朱建辉; 吴政庚; 李晓斌; 李福强

    2011-01-01

    目的 探讨心肌酶与APACHE Ⅱ评分在ICU非心肌梗死(AMI)患者预后中的价值及其相关性.方法 从2007年11月至2010年10月入住本院ICU的非AMI患者中随机选取199例,其中存活132例(存活组),死亡67例(死亡组),均于入院时进行APACHE Ⅱ评分,24 h内常规检测各项心肌酶指标.比较2组患者心肌酶测定结果、APACHE Ⅱ评分,以及心肌酶各项指标与APACHE Ⅱ评分的相关性.结果 死亡组心肌酶各项指标明显高于存活组,2组间比较差异有统计学意义(P<0.01);存活组APACHE Ⅱ(12.70±7.85)分,低于死亡组的(24.80±7.46)分,2组间比较差异有统计学意义(P<0.01);心肌酶各项指标与APACHE Ⅱ评分均呈高度正相关.结论 心肌酶和APACHE Ⅱ评分反映出ICU非AMI患者疾病的严重程度和转归,均可作为评估患者预后的参考指标之一.%Objective To investigate the clinical value of and correlation between myocardium enzymes and APACHE Ⅱ score in the prognosis o~ intensive care unit(ICU) patients without AMI. Methods During Nov. 2007 to Oct. 2010,199 cases of ICU pa tients without AMI in our hospital were selected randomly,among which 132 cases survived(survival group)and 67 cases were dead (death group). APACHE Ⅱ score at admission and myocardium enzymes detection in 24 hours were carried out. The detection re sults of myocardium enzymes and APACHE Ⅱ score were compared between the two groups and the correlation between various myocardium enzymes and APACHE Ⅱ was analyzed. Results Serum levels of all myocardium enzymes in the death group were significantly higher than those in the survival group(P<0.01). APACHE Ⅱ score of the death group were significantly higher than that of the survival group (P<0.01). There was fine correlation between various myocardium enzymes and APACHE Ⅱ score. Conclusion Myocardium enzymes and APACHE Ⅱ score can reflect the severity and turnover of the diseases and can be used for the prognosis of

  16. Impact of Diabetes Mellitus on Prognosis of AMI Patients Undergoing PCI%糖尿病对直接冠状动脉介入治疗的急性心肌梗死患者预后的影响研究

    Institute of Scientific and Technical Information of China (English)

    高玉龙; 王春梅; 朱小玲; 艾辉; 李艳芳

    2013-01-01

    目的 观察糖尿病(DM)对接受直接经皮冠状动脉介入治疗(PCI)的急性心肌梗死(AMI)患者预后的影响.方法 回顾性分析因AMI于2010-2011年在我院住院行直接PCI的患者794例,根据是否患有糖尿病分为DM组(175例)与对照组(619例).通过观察两组临床特点、造影结果、术后心肌梗死溶栓试验(TIMI)血流及住院期间病死率评价预后.结果 与对照组相比,DM组患者年龄、高血压史、发病至就诊时间、术前TIMI血流0级、病变血管数、梗死相关动脉(IRA)开通时间、术后无复流或慢血流发生比例、住院期间病死率均增高,而男性比例、吸烟、左室射血分数、术后TIMI血流3级比例、ST段回落率均降低,两组间差异有统计学意义(均P<0.05);Logistic回归分析显示:DM与直接PCI术后住院期间病死率有回归关系[OR=2.034,95%CI(0.976,3.988),P=0.031].结论 DM患者直接PCI术后心功能及组织灌注差,住院期间病死率高,应重视这些临床特点、加强监护、积极干预.%Objective To investigate the impact of diabetes mellitus ( DM ) on prognosis of patients with acute myo-cardial infarction ( AMI) who underwent primary percutaneous coronary intervention ( PCI ). Methods The data of 794 AMI patients undergoing PCI from 2010 to 2011 were analyzed retrospectively. The patients were divided into DM group ( n = 175 ), the others into control group ( n = 619 ). The clinical features, angiographic results, post - operative TIMI flow and hospital mortality were observed to evaluate prognosis. Results As compared with control group, age, hypertension, onset to treatment time, pre - operative TIMI flow 0 degree, number of diseased vessels, IRA - time, post - operative non - occurrence rate of re-flow or slow flow, hospital mortality increased, while the proportion of males, smoking, left ventricular ejection fraction, rate of post - operative TIMI flow 3 degree, ST segment drop rate decreased, the difference

  17. Influencing factor analysis of recovering to normal atrioventricular nodal conduction in patients with AMI complicated III° AVB%急性心肌梗死合并III°房室传导阻滞恢复正常房室结传导的影响因素分析

    Institute of Scientific and Technical Information of China (English)

    蔺红梅; 李帮清

    2016-01-01

    目的:探讨急性心肌梗死(AMI)合并III°房室传导阻滞(III°AVB)患者恢复正常的房室结传导的影响因素。方法:选择AMI合并III°AVB患者82例,根据III°AVB是否恢复正常房室结传导分为恢复组51例,未恢复组31例(其中安装永久人工心脏起搏器3例,死亡28例)。观察两组Killip分级、心源性休克等因素的差异。结果:AMI合并III°AVB患者中,房室结传导恢复组与未恢复组在年龄、性别比例、吸烟史、高血压病史、糖尿病史、缺血预适应、到达急诊室时间、入院心率水平、入院收缩压、血红蛋白水平及实施早期再灌注治疗方面,差异无显著性(P>0.05)。与恢复组比较,未恢复组Killip ≥II级(39.2%比80.6%)、心源性休克(21.6%比45.2%)、前壁梗死比例(7.8%比32.3%)、肌酐水平[(107.25±6.69)μmol/L比(132.43±11.52)μmol/L ]及死亡率(0%比90.3%)显著升高,而下壁梗死比例(92.2%比67.7%)显著降低,P<0.05或<0.01。多因素Logstic回归分析显示,Killip分级为影响AMI合并III°AVB患者房室结功能恢复正常的独立预测因素(OR=0.190,P=0.002)。结论:Killip分级为影响急性心肌梗死合并III°房室传导阻滞患者房室结功能恢复的独立预测因素。%Objective:To explore the influencing factors of recovering to normal atrioventricular nodal conduction (AVNC) in patients with acute myocardial infarction (AMI) complicated III atrioventricular block (AVB) .Meth‐ods:According to III AVB recovered to normal or not ,a total of 82 AMI complicated III AVB patients were divid‐ed into recovery group (n=51) and non- recovery group (n=31 ,including three cases undergoing permanent pace‐maker implantation and 28 dead cases) .The relationship among diabetes mellitus (DM) history ,ischemic precondi‐tioning (IP) ,levels of creatinine (Cr) and hemoglobin (Hb) at

  18. 谭恩美小说的女性话语与种族意识——以《接骨师之女》为例%The Female Words and Ethnic Consciousness of Amy Tan's Novels --Taking The Bone setter's Daughter as an Example

    Institute of Scientific and Technical Information of China (English)

    杨峰

    2012-01-01

    Amy Tan is a famous contemporary American Chinese woman novelist. Her works primarily reflect the predicament and struggle of Chinese - born women in western countries as well as their mental process. Taking her masterpiece The Bone - setter' s Daughter as an example, this paper analyses her works at the angles of female words and ethnic con- sciousness, and discusses how the main characters realize and regain their identity and reestablish their subjective status in a social position of double remoteness.%谭恩美是当代著名美籍华裔女作家,其作品主要展现了身处西方社会的华裔女性的困境和抗争,以及她们的心路历程。本文以其代表作《接骨师之女》为例,从女性话语和种族意识的角度去解读其作品,探讨其中的主要人物是如何在双重边缘性境地中认识和找回自己的身份并重塑自身的主体地位的。

  19. Chronic total occlusion in a non-infarct-related artery is closely associated with increased five-year mortality in patients with ST-segment elevation acute myocardial infarction undergoing primary percutaneous coronary intervention (from the CREDO-Kyoto AMI registry).

    Science.gov (United States)

    Watanabe, Hiroki; Morimoto, Takeshi; Shiomi, Hiroki; Furukawa, Yutaka; Nakagawa, Yoshihisa; Ando, Kenji; Kadota, Kazushige; Kimura, Takeshi

    2017-02-03

    We sought to investigate the clinical impact of chronic total occlusion (CTO) in a non-infarct-related artery (IRA) on long-term cardiovascular outcomes in patients with ST-elevation myocardial infarction (STEMI). Among 5,429 patients enrolled in the CREDO-Kyoto AMI registry, the current study population consisted of 2,045 STEMI patients with multivessel disease (MVD) who underwent primary PCI within 24 hours after symptom onset. The cumulative five-year, 30-day and 30-day to five-year incidences of all-cause death were all significantly higher in the CTO group than in the non-CTO group (37.0% versus 22.0%, log-rank pfive years, during the initial 30 days, and beyond 30 days and up to five years (hazard ratio [HR]: 1.47, 95% confidence interval [CI]: 1.18-1.84, p=0.0009; HR: 1.49, 95% CI: 1.04-2.13, p=0.03; and HR: 1.61, 95% CI: 1.23-2.07, p=0.0006, respectively). CTO in a non-IRA was associated with increased five-year mortality in STEMI patients with MVD. This was consistently seen even after excluding early deaths within 30 days of the index STEMI event.

  20. Sense of "Self":A Sure Path to Real Happiness——A critical reading of The Joy Luck Club by Amy Tan%“自我意识”:通向幸福的必由之路——读谭恩美《喜福会》

    Institute of Scientific and Technical Information of China (English)

    江蕙

    2012-01-01

    长篇小说《喜福会》是美国华裔女作家谭恩美的代表作,于上世纪末出版后即获得很大成功并很快成为学术界研究的热点,评论者角度各异,观点不一。本文以女性主义和文化研究为依托,吸取心理学人格结构理论的研究成果,运用文本细读的批评方法,分析在不同时代与文化背景下,母女两代人在寻求幸福的道路上,自我意识由缺失到觉醒,迷失到重拾的过程,侧重探讨了自我意识与个人幸福之间的关系。%The Joy Luck Club,Chinese-American female writer Amy Tan's masterpiece,won great popularity immediately after its publication at the end of the twentieth century and has soon become a hot subject for academic studies home and abroad.Following the principles of Feminism and Cultural Studies,as well as psychological research results in "the structure of mind",this article analyzes the life stories of mothers and daughters in the novel with regards of their losing and regaining "self-consciousness" while pursuing happiness in different time and social backgrounds.It focuses on investigating the interrelationship between "sense of self" and personal happiness.

  1. Judging Amy: Automated legal assessment using OWL 2

    NARCIS (Netherlands)

    van de Ven, S.; Hoekstra, R.; Breuker, J.; Wortel, L.; El-Ali, A.

    2008-01-01

    One of the most salient tasks in law is legal assessment, and concerns the problem of determining whether some case is allowed or disallowed given an appropriate body of legal norms. In this paper we describe a system and Protégé 4 plugin, called OWL Judge, that uses standard OWL 2 DL reasoning for

  2. Content Analytic Comparison of Four Expert Counselors' Approaches to Family Treatment: Ackerman, Bowen, Jackson, and Whitaker.

    Science.gov (United States)

    Friedlander, Myrna L.; And Others

    1985-01-01

    Used a multidimensional content analysis to compare four expert counselors' approaches to family treatment. Two common change factors in family counseling were proposed: disruption of the existing balance of power among family members and education in the nature and strength of family systems. (JAC)

  3. A Case Report: Lichen Simplex Chronicus Mimicking Bowen%u2019s Disease

    Directory of Open Access Journals (Sweden)

    Ižlknur Balta

    2014-02-01

    Full Text Available Lichen simplex chronicus (LSC, also known as ‘’neurodermatitis’’. It can present clinically as isolated or multiple lichenified thickened plaques that are usually hyper pigmented and excoriated with accentuated skin markings. The diagnosis of LSC is usually easily made from characteristic lesions. In more difficult cases histopathological study is useful. A 59–year–old male patient had a one-year history of erythema and crusts beginning on the left lumbar region and enlarging peripherally. His past medical history was unremarkable. Dermatological examination revealed 3x4 cm sharply demarcated, erythematous, slightly scaling and crusted solitary plaque on the left lumbar region.  Because of  the clinical characteristics of the lesions, Bowen’s disease was suspected clinically in the diagnosis of the disease. Histological examination was compatible with the diagnosis of LSC.  Thus, a diagnosis of Bowen’s disease was eliminated. Our case is presented in order to remind that LSC should be kept in mind, in differential diagnosis of  Bowen’s disease.

  4. 78 FR 60900 - Kiewit Power Constructors Co. et al. (Avalotis Corp., Bowen Engineering Corporation, Commonwealth...

    Science.gov (United States)

    2013-10-02

    ... Engineering Corporation, Commonwealth Dynamics, Inc., Gibraltar Chimney International, LLC, Hamon Custodis..., Commonwealth Dynamics, Inc., Gibraltar Chimney International, LLC, Hamon Custodis, Inc., Hoffmann, Inc...-Atlantic, LLC)), 8802 N. Meridian St.Indianapolis, IN 46260 Commonwealth Dynamics, Inc., 95 Court Street...

  5. Studio della misura di Sinai-Ruelle-Bowen in un sistema semplice

    CERN Document Server

    Porta, Marcello

    2010-01-01

    In this thesis we discuss some applications of the theory of Anosov systems to nonequilibrium statistical mechanics. In particular, we perform a perturbative check of the Gallavotti-Cohen fluctuation relation for a simple Anosov system; we find that the lack of differentiability of the time reversal operator implies a violation of the Gallavotti-Cohen fluctuation relation.

  6. Feasibility of conducting wetfall chemistry investigations around the Bowen Power Plant

    Energy Technology Data Exchange (ETDEWEB)

    Chen, N.C.J.; Patrinos, A.A.N.

    1979-10-01

    The feasibility of expanding the Meteorological Effects of Thermal Energy Releases - Oak Ridge National Laboratory (METER-ORNL) research at Bower Power Plant, a coal-fired power plant in northwest Georgia, to include wetfall chemistry is evaluated using results of similar studies around other power plants, several atmospheric washout models, analysis of spatial variability in precipitation, and field logistical considerations. An optimal wetfall chemistry network design is proposed, incorporating the inner portion of the existing rain-gauge network and augmented by additional sites to ensure adequate coverage of probable target areas. The predicted sulfate production rate differs by about four orders of magnitude among the models reviewed with a pH of 3. No model can claim superiority over any other model without substantive data verification. The spatial uniformity in rain amount is evaluated using four storms that occurred at the METER-ORNL network. Values of spatial variability ranged from 8 to 31% and decreased as the mean rainfall increased. The field study of wetfall chemistry will require a minimum of 5 persons to operate the approximately 50 collectors covering an area of 740 km/sup 2/. Preliminary wetfall-only samples collected on an event basis showed lower pH and higher electrical conductivity of precipitation collected about 5 km downwind of the power plant relative to samples collected upwind. Wetfall samples collected on a weekly basis using automatic samplers, however, showed variable results, with no consistent pattern. This suggests the need for event sampling to minimize variable rain volume and multiple-source effects often associated with weekly samples.

  7. On the Value of LIU Bowen%刘伯温的价值观

    Institute of Scientific and Technical Information of China (English)

    俞美玉

    2012-01-01

    基于刘伯温对宇宙、自然、社会管理建设、以及人生既有理论上思考又有身体力行的实践,从刘伯温生甲经历、功勋成就以及著书立说里梳理得出:成己而后利他,丰满的自我而后创造了社会价值,融自我价值社会价值为一体是刘伯温的价值观,是高屋建瓴并且是具有超越时代性意义的价值观。%Based on Liuji's views on universe, nature, construction of social management, and the life with theoretical reflection and personal practice, the article puts forward the opinions as follows: Altruism should be carried out after self- achievement; Full-self first can create social value; The integration of self-value with social value is not only a LIU Bowen's value, but also a great value beyond time significance.

  8. Content Analytic Comparison of Four Expert Counselors' Approaches to Family Treatment: Ackerman, Bowen, Jackson, and Whitaker.

    Science.gov (United States)

    Friedlander, Myrna L.; And Others

    1985-01-01

    Used a multidimensional content analysis to compare four expert counselors' approaches to family treatment. Two common change factors in family counseling were proposed: disruption of the existing balance of power among family members and education in the nature and strength of family systems. (JAC)

  9. Cross-Cultural Revelation of Amy Tan“The Joy Luck Club”

    Institute of Scientific and Technical Information of China (English)

    LIU Chang

    2016-01-01

    Cross-cultural communication refers to the different cultural backgrounds of communication between individuals, that is people from different cultural backgrounds of the interaction between what happened.“The Joy Luck Club”considers Chinese American, a special“the other”image, as the object, proceeding from the relationship between mother and daughter from differ-ent cultural backgrounds, with a view to look at the cultural conflict and integration under the global view to discuss the differ-ence and communication between Chinese and eastern culture. Therefore, it has an important meaning for us to research cross-cultural communication.

  10. Maria Edgeworth's Angelina, or L'amie Inconnue: queer materiality and the woman writer's grotesque body.

    Science.gov (United States)

    Gonda, Caroline

    2013-01-01

    Despite its many similarities to her better-known novel Belinda, Maria Edgeworth's Angelina is not usually read as a work about lesbianism--even though it begins with the heroine eloping to live with another woman. This article explores same-sex relationships in Angelina and suggests reasons for the work's comparative neglect by lesbian criticism. It examines the process by which the heroine's "unknown friend," the novelist Araminta, moves from being "nobody," a textual construct, to a woman all too thoroughly and grotesquely embodied; and it discusses the role of queer objects, including literary texts, in that process of embodiment.

  11. Mechanical complications after percutaneous coronary intervention in ST-elevation myocardial infarction (from APEX-AMI).

    Science.gov (United States)

    French, John K; Hellkamp, Anne S; Armstrong, Paul W; Cohen, Eric; Kleiman, Neil S; O'Connor, Christopher M; Holmes, David R; Hochman, Judith S; Granger, Christopher B; Mahaffey, Kenneth W

    2010-01-01

    A decrease in mechanical complications after ST-elevation myocardial infarction may have contributed to improved survival rates associated with reperfusion by primary percutaneous coronary intervention (PCI). Mechanical complications occurred in 52 of 5,745 patients (0.91%) in the largest reported randomized trial in which primary PCI was the reperfusion strategy. The frequencies were 0.52% (30) for cardiac free-wall rupture (tamponade), 0.17% (10) for ventricular septal rupture, and 0.26% (15) for papillary muscle rupture (3 patients had 2 complications). Ninety-day survival rates were 37% (11) for cardiac free-wall rupture, 20% (2) for ventricular septal rupture, and 73.3% (11) for papillary muscle rupture. These mechanical complications occurred at a median of 23.5 hours (interquartile range 5.0 to 76.8) after symptom onset and were associated with 44% (23 of 52) survival through 90 days, which accounted for 11% of the 90-day mortality. Factors associated with mechanical complications were older age, female gender, Q waves, presence of radiologic pulmonary edema, and increased prerandomization troponin levels. In conclusion, rates of mechanical complications are lower with primary PCI than those previously reported after fibrinolytic therapy.

  12. Educator Sexual Misconduct and Nondisclosure Agreements: Policy Guidance from Missouri's Amy Hestir Student Protection Act

    Science.gov (United States)

    Surface, Jeanne L.; Stader, David L.; Armenta, Anthony D.

    2014-01-01

    Allegations of sexual misconduct may prompt districts to enter into non-disclosure or settlement agreements with alleged perpetrators in exchange for a recommendation. Non-disclosure settlements typically limit how much information districts can share with other districts. This process, often referred to as "passing the trash," can be…

  13. "AMI" Go Home - Assessing the Realignment of U.S. Army Forces in Europe

    Science.gov (United States)

    2005-03-18

    a major U.S. investment.37 According to Stuart Drury of the Joint Chiefs of Staff, deploying would be much more difficult from Eastern Europe...35 Ibid, xvi. 36 Ibid,12. 37 Ibid, 29. 38 Stuart P. Drury , “The Argument Against Relocating U.S. Forces in Europe,” National Defense University...Europe in the 21st Century,” Parameters (Autumn 2004): 61. 53 Colin Powell, “A Strategy of Partnership,” Foreign Affairs (Jan/Feb 2004): 22. 54 Michael

  14. Freedom & Responsibility: A Glorious Counterpoint. AMI/USA Conference (Boston, Massachusetts, July 20-23, 2000).

    Science.gov (United States)

    American Montessori International of the United States, Inc., Rochester, NY.

    This conference proceedings compile presentations from a 2000 meeting of the American Montessori International of the United States, focusing on the Montessori view toward freedom and responsibility and addressing other issues of importance in Montessori education. The papers presented at the conference are: (1) "Strategies for You and Your…

  15. Advanced sampling theory with applications how Michael ‘selected’ Amy

    CERN Document Server

    Singh, Sarjinder

    2003-01-01

    This book is a multi-purpose document. It can be used as a text by teachers, as a reference manual by researchers, and as a practical guide by statisticians. It covers 1165 references from different research journals through almost 1900 citations across 1194 pages, a large number of complete proofs of theorems, important results such as corollaries, and 324 unsolved exercises from several research papers. It includes 159 solved, data-based, real life numerical examples in disciplines such as Agriculture, Demography, Social Science, Applied Economics, Engineering, Medicine, and Survey Sampling. These solved examples are very useful for an understanding of the applications of advanced sampling theory in our daily life and in diverse fields of science. An additional 173 unsolved practical problems are given at the end of the chapters. University and college professors may find these useful when assigning exercises to students. Each exercise gives exposure to several complete research papers for researchers/stude...

  16. 3rd Workshop on Semantic Ambient Media Experience (SAME) - In Conjunction with AmI-2010

    Science.gov (United States)

    Lugmayr, Artur; Stockleben, Bjoern; Kaario, Juha; Pogorelc, Bogdan; Risse, Thomas

    The SAME workshop takes place for the 3rd time in 2010, and it's theme in this year was creating the business value-creation, vision, media theories and technology for ambient media. SAME differs from other workshops due to its interactive and creative touch and going beyond simple powerpoint presentations. Several results will be published by AMEA - the AMbient Media Association (www.ambientmediaassociation.org.

  17. WiMax radio deployment in a smart grid AMI use case

    Energy Technology Data Exchange (ETDEWEB)

    Bulumulla, S.; DeGuzman, R.; Mahony, M.; Garrity, J. [General Electric, Mississauga, ON (Canada)

    2009-07-01

    This presentation described the deployment of a WiMax radio in a smart grid advanced metering infrastructure by CenterPoint Energy Houston Electric in the Houston, Texas area. The project involved the first year of a multi-year project roll-out to over 2 million customers. The WiMax radio system was provided by GE Digital Energy. The architecture and WiMax radios were illustrated and outlined. The presentation described the radio infrastructure and deployment with particular reference to the cell relay node; take out point; radio propagation tests; and link test. It was concluded that when the system is fully operational, end use customers will be able to monitor electrical usage in near real time and offer on-line control of smart appliances within residence. 2 figs.

  18. Artificial micro RNA (amiRNA) induced gene silencing in alfalfa (Medicago sativa)

    Science.gov (United States)

    Gene silencing is a powerful technique that allows the study of the function of specific genes by selectively reducing their transcription. Several different approaches can be used; however, they all have in common the artificial generation of single-stranded small RNAs that are utilized by the endo...

  19. Reinventing the Formal Definition of Limit: The Case of Amy and Mike

    Science.gov (United States)

    Swinyard, Craig

    2011-01-01

    Relatively little is known about how students come to reason coherently about the formal definition of limit. While some have conjectured how students might think about limits formally, there is insufficient empirical evidence of students making sense of the conventional [superscript epsilon]-[delta] definition. This paper provides a detailed…

  20. Pour une typologie des faux-amis en français et en espagnol

    Directory of Open Access Journals (Sweden)

    Mari Carmen Jorge Chaparro

    2012-01-01

    Full Text Available When two languages are compared a semantic reconstruction comes to show the difference in sense of certain terms with a common origin. That is the case with false friends. In this study I establish a typology that compares certain representative cases in French and in Spanish analyzing the degree of proximity between them, from the point of view of etymology and that of meaning.Cuando se comparan dos lenguas una reconstrucción semántica permite comprobar la divergencia de sentido de ciertos términos con un origen común. Es el caso de los denominados falsos amigos. En este estudio establezco una tipología que compara ciertos casos representativos en francés y en español analizando el grado de proximidad que existe entre ellos, desde el punto de vista etimológico y del contenido significativo.

  1. Contamination of the Central Sunyaev--Zel'dovich Decrements in AMiBA Galaxy Cluster Observations

    CERN Document Server

    Liu, Guo-Chin; Wu, Jiun-Huei Proty; Ho, Paul T P; Huang, Chih-Wei Locutus; Liao, Yu-Wei; Lin, Kai-Yang; Molnar, Sandor M; Nishioka, Hiroaki; Koch, Patrick M; Umetsu, Keiichi; Wang, Fu-Cheng; Altamirano, Pablo; Chang, Chia-Hao; Chang, Shu-Hao; Chang, Su-Wei; Chen, Ming-Tang; Han, Chih-Chiang; Huang, Yau-De; Hwang, Yuh-Jing; Jiang, Homin; Kesteven, Michael; Kubo, Derek; Li, Chao-Te; Martin-Cocher, Pierre; Oshiro, Peter; Raffin, Philippe; Wei, Tashun; Wilson, Warwick

    2010-01-01

    We investigate the contamination of the Sunyaev--Zel'dovich (SZ) effect for six galaxy clusters, A1689, A1995, A2142, A2163, A2261, and A2390, observed by the Y. T. Lee Array for Microwave Background Anisotropy during 2007. With the range of baselines used, we find that the largest effect (of order 13%-50% of the central SZ flux density) comes from primary anisotropies in the cosmic microwave background and exceeds the thermal noise in all six cases. Contamination from discrete radio sources is estimated to be at a level of (3%-60%) of the central SZ flux density. We use the statistics of these contaminating sources to estimate and correct the errors in the measured SZ effects of these clusters.

  2. ESC/ACC联合研讨 AMI 的处理

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ 主持:由美国DiMarco JP(Virinia医学中心)和瑞士Luscher TF(苏黎世大学医院)主持.共有4个发言. 主持人发言:这场参加者踊跃的研讨会的交流重点是度过了最早的急性期之后的AMI病人的处理.

  3. On Amy Tan's The Joy Luck Club from the Perspective of Symbolism

    Institute of Scientific and Technical Information of China (English)

    SHAO Yi-hong

    2016-01-01

    This paper tries to explore the symbolic meanings in Tan's The Joy Luck Club from the following two parts: symbolic meanings of food and symbolic meaning of water. By employing symbolism, Tan extends the traditional Chinese images into cultural ones, in which the conflicts between Chinese and American cultures are symbolized and allegorized, and the novel holds more symbolic meanings with deeper cultural implication. The happy ending of this novel illustrates that the ancient China and the young American eventually reach mutual communication and understanding.

  4. Bowen Family Systems Theory and Its Relationship to Teachers: Does Differentiation of Self Predict Teacher Job Satisfaction?

    Science.gov (United States)

    Cochran, Noal Baxter

    2011-01-01

    Educational leaders are charged with maintaining the academic success of students, the faith of stakeholders in the educational process, and the growth of the educational profession. These objectives have become difficult during a time of noticeable discontent among the stakeholders of educational systems. The discontent is noted strongly among…

  5. Comparing CO2 flux data from eddy covariance methods with bowen ratio energy balance methods from contrasting soil management

    Science.gov (United States)

    Measuring CO2 fluxes from contrasting soil management practices is important for understanding the role of agriculture in source-sink relationship with CO2 flux. There are several micrometeorological methods for measuring CO2 emissions, however all are expensive and thus do not easily lend themselve...

  6. Analysis of the climate variability on Lake Nasser evaporation based on the Bowen ratio energy budget method.

    Science.gov (United States)

    Elsawwaf, Mohamed; Willems, Patrick

    2012-04-01

    Variations in lake evaporation have a significant impact on the energy and water budgets of lakes. Understanding these variations and the role of climate is important for water resources management as well as predicting future changes in lake hydrology as a result of climate change. This study presents a comprehensive, 10-year analysis of seasonal, intraseasonal, and interannual variations in lake evaporation for Lake Nasser in South Egypt. Meteorological and lake temperature measurements were collected from an instrumented platform (Raft floating weather station) at 2 km upstream ofthe Aswan High Dam. In addition to that, radiation measurements at three locations on the lake: Allaqi, Abusembel and Arqeen (respectively at 75, 280 and 350 km upstream of the Aswan High Dam) are used. The data were analyzed over 14-day periods from 1995 to 2004 to provide bi-weekly energy budget estimates of evaporation rate. The mean evaporation rate for lake Nasser over the study period was 5.88 mm day(-1), with a coefficient of variation of 63%. Considerable variability in evaporation rates was found on a wide range of timescales, with seasonal changes having the highest coefficient of variation (32%), followed by the intraseasonal (28%) and interannual timescales (11.6%; for summer means). Intraseasonal changes in evaporation were primarily associated with synoptic weather variations, with high evaporation events tending to occur during incursions of cold, dry air (due, in part, to the thermal lag between air and lake temperatures). Seasonal variations in evaporation were largely driven by temperature and net energy advection, but are out-of-phase with changes in wind speed. On interannual timescales, changes in summer evaporation rates were strongly associated with changes in net energy advection and showed only moderate connections to variations in temperature or humidity.

  7. Evolution in Cloud Population Statistics of the MJO: From AMIE Field Observations to Global-Cloud Permitting Models Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Kollias, Pavlos [McGill Univ., Montreal, QC (Canada). Atmospheric and Oceanic Sciences Dept.

    2017-02-09

    This is a multi-institutional, collaborative project using a three-tier modeling approach to bridge field observations and global cloud-permitting models, with emphases on cloud population structural evolution through various large-scale environments. Our contribution was in data analysis for the generation of high value cloud and precipitation products and derive cloud statistics for model validation. There are two areas in data analysis that we contributed: the development of a synergistic cloud and precipitation cloud classification that identify different cloud (e.g. shallow cumulus, cirrus) and precipitation types (shallow, deep, convective, stratiform) using profiling ARM observations and the development of a quantitative precipitation rate retrieval algorithm using profiling ARM observations. Similar efforts have been developed in the past for precipitation (weather radars), but not for the millimeter-wavelength (cloud) radar deployed at the ARM sites.

  8. Invariance of the magnetic behavior and AMI in ferromagnetic biphase films with distinct non-magnetic metallic spacers

    Energy Technology Data Exchange (ETDEWEB)

    Silva, E.F. [Departamento de Física, Universidade Federal do Rio Grande do Norte, 59078-900 Natal, RN (Brazil); Departamento de Física, Universidade Federal de Pernambuco, 50670-901 Recife, PE (Brazil); Gamino, M. [Departamento de Física, Universidade Federal de Pernambuco, 50670-901 Recife, PE (Brazil); Instituto de Física, Universidade Federal do Rio Grande de Sul, 91501-970 Porto Alegre, RS (Brazil); Andrade, A.M.H. de [Instituto de Física, Universidade Federal do Rio Grande de Sul, 91501-970 Porto Alegre, RS (Brazil); Vázquez, M. [Instituto de Ciencia de Materiales de Madrid, CSIC, 28049 Madrid (Spain); Correa, M.A. [Departamento de Física, Universidade Federal do Rio Grande do Norte, 59078-900 Natal, RN (Brazil); Bohn, F., E-mail: felipebohn@fisica.ufrn.br [Departamento de Física, Universidade Federal do Rio Grande do Norte, 59078-900 Natal, RN (Brazil)

    2017-02-01

    We investigate the quasi-static magnetic, magnetotransport, and dynamic magnetic properties in ferromagnetic biphase films with distinct non-magnetic metallic spacer layers. We observe that the nature of the non-magnetic metallic spacer material does not have significant influence on the overall biphase magnetic behavior, and, consequently, on the magnetotransport and dynamic magnetic responses. We focus on the magnetoimpedance effect and verify that the films present asymmetric magnetoimpedance effect. Moreover, we explore the possibility of tuning the linear region of the magnetoimpedance curves around zero magnetic field by varying the probe current frequency in order to achieve higher sensitivity values. The invariance of the magnetic behavior and the asymmetric magnetoimpedance effect in ferromagnetic biphase films with distinct non-magnetic metallic spacers place them as promising candidates for probe element and open possibilities to the development of lower-cost high sensitivity linear magnetic field sensor devices.

  9. Ægtefællers oplevelser, når deres partner indlægges med AMI

    DEFF Research Database (Denmark)

    Hansen, Birgitte; Lomborg, Kirsten

    2006-01-01

    addressed the issue. The purpose of this article is to report on findings from a qualitative descriptive study of spouses’ experiences when their partner was admitted to hospital with acute myocardial infarction. Three spouses were interviewed using a semi-structured interview guide. Findings indicated...... that – even though emotional support was advertised by the spouses – need might not be fully recognised by the health care professional. A discussion of findings is elaborated, drawing on Ida J. Orlando’s ideas on nurse-patient relationships. The conclusion is drawn that the recent change in treatment...

  10. Emprunts du français et de l’allemand au latin. Vrais et faux amis

    OpenAIRE

    Corbellari, Michel

    2014-01-01

    L’étude comparée des latinismes en français et en allemand nous amène à distinguer plusieurs cas : 1. Mots ou expressions qui existent dans les deux langues et ont le même sens Ils sont nombreux. das Alter Ego l’alter ego der Cannabis le cannabis der Deus ex machina le deus ex machina das Exvoto l’ex-voto das Imprimatur l’imprimatur der Index l’index (également : l’indice) der Malus le malus die Mater dolorosa la mater dolorosa der Modus Operandi le modus operandi (également : le mode opérato...

  11. AMI SZ observation of galaxy-cluster merger CIZA J2242+5301: perpendicular flows of gas and dark matter

    Science.gov (United States)

    Rumsey, Clare; Perrott, Yvette C.; Olamaie, Malak; Saunders, Richard D. E.; Hobson, Michael P.; Stroe, Andra; Schammel, Michel P.; Grainge, Keith J. B.

    2017-10-01

    Arcminute Microkelvin Imager observations towards CIZA J2242+5301, in comparison with observations of weak gravitational lensing and X-ray emission from the literature, are used to investigate the behaviour of non-baryonic dark matter (NBDM) and gas during the merger. Analysis of the Sunyaev-Zel'dovich (SZ) signal indicates the presence of high pressure gas elongated perpendicularly to the X-ray and weak-lensing morphologies, which, given the merger-axis constraints in the literature, implies that high pressure gas is pushed out into a linear structure during core passing. Simulations in the literature closely matching the inferred merger scenario show the formation of gas density and temperature structures perpendicular to the merger axis. These SZ observations are challenging for modified gravity theories in which NBDM is not the dominant contributor to galaxy-cluster gravity.

  12. Miks ühel õnnestub ja teisel mitte? / Amy Edmonson, Richard Bohmer, Gary Pisano ; tõlk. Kadre Vaik

    Index Scriptorium Estoniae

    Edmonson, Amy

    2003-01-01

    16 meditsiinikeskuses läbi viidud uuringust eesmärgiga jälgida kirurgimeeskondade tööd ning kohanemist uute töömeetoditega. Kommenteerivad Toomas-Andres Sulling, Tiit Ojaveski ja Ela Velström. Vt. samas: Uus meetod murtud südame parandamiseks; Kahe haigla lugu. Lisa: Õppiv liider

  13. A cluster randomised trial to assess the impact of clinical pathways on AMI management in rural Australian emergency departments

    Directory of Open Access Journals (Sweden)

    Snow Pamela C

    2009-05-01

    Full Text Available Abstract Background People living in rural Australia are more likely to die in hospital following an acute myocardial infarction than those living in major cities. While several factors, including time taken to access hospital care, contribute to this risk, it is also partially attributable to the lower uptake of evidence-based guidelines for the administration of thrombolytic drugs in rural emergency departments where up to one-third of eligible patients do not receive this life-saving intervention. Clinical pathways have the potential to link evidence to practice by integrating guidelines into local systems, but their impact has been hampered by variable implementation strategies and sub-optimal research designs. The purpose of this study is to determine the impact of a five-step clinical pathways implementation process on the timely and efficient administration of thrombolytic drugs for acute myocardial infarctions managed in rural Australian emergency departments. Methods/Design The design is a two-arm, cluster-randomised trial with rural hospital emergency departments that treat and do not routinely transfer acute myocardial infarction patients. Six rural hospitals in the state of Victoria will participate, with three in the intervention group and three in the control group. Intervention hospitals will participate in a five-step clinical pathway implementation process: engagement of clinicians, pathway development according to local resources and systems, reminders, education, and audit and feedback. Hospitals in the control group will each receive a hard copy of Australian national guidelines for chest pain and acute myocardial infarction management. Each group will include 90 cases to give a power of 80% at 5% significance level for the two primary outcome measures: proportion of those eligible for thrombolysis receiving the drug and time to delivery of thrombolytic drug. Discussion Improved compliance with thrombolytic guidelines via clinical pathways will increase acute myocardial infarction survival rates in rural hospitals and thereby help to reduce rural-urban mortality inequalities. Such knowledge translation has the potential to be adapted for a range of clinical problems in a wide array of settings. Trial registration Australia New Zealand Clinical Trials Registry code ACTRN12608000209392.

  14. Evolution in Cloud Population Statistics of the MJO: From AMIE Field Observations to Global Cloud-Permitting Models

    Energy Technology Data Exchange (ETDEWEB)

    Dudhia, Jimy [National Center for Atmospheric Research (UCAR), Boulder, CO (United States)

    2015-10-05

    The NCAR role in this project was to host a visiting PostDoc from the University of Miami. The NCAR PI (Jimy Dudhia) provided oversight of the PostDoc's work and mentoring and guidance as needed throughout the duration of the project. The University of Miami (the lead of this project), will provide the final technical report on the main work carried out under this proposal, which will be submitted once their no-cost extension period is completed.

  15. Using Kinesiology: A Comparison of Applied Veins in the Subdisciplines. The Twenty-sixth Amy Morris Honors Lecture 1992.

    Science.gov (United States)

    Harris, Janet C.

    1993-01-01

    Compares three domains in kinesiology with regard to essential professional competencies: biophysical sciences focused on exercise and sport, behavioral/sociocultural sciences focused on sport, and pedagogical sciences focused on school physical education. The paper compares the relative emphases placed on technical and critical/reflective…

  16. Invariance of the magnetic behavior and AMI in ferromagnetic biphase films with distinct non-magnetic metallic spacers

    Science.gov (United States)

    Silva, E. F.; Gamino, M.; Andrade, A. M. H. de; Vázquez, M.; Correa, M. A.; Bohn, F.

    2017-02-01

    We investigate the quasi-static magnetic, magnetotransport, and dynamic magnetic properties in ferromagnetic biphase films with distinct non-magnetic metallic spacer layers. We observe that the nature of the non-magnetic metallic spacer material does not have significant influence on the overall biphase magnetic behavior, and, consequently, on the magnetotransport and dynamic magnetic responses. We focus on the magnetoimpedance effect and verify that the films present asymmetric magnetoimpedance effect. Moreover, we explore the possibility of tuning the linear region of the magnetoimpedance curves around zero magnetic field by varying the probe current frequency in order to achieve higher sensitivity values. The invariance of the magnetic behavior and the asymmetric magnetoimpedance effect in ferromagnetic biphase films with distinct non-magnetic metallic spacers place them as promising candidates for probe element and open possibilities to the development of lower-cost high sensitivity linear magnetic field sensor devices.

  17. The highest-frequency detection of a radio relic: 16-GHz AMI observations of the `Sausage' cluster

    CERN Document Server

    Stroe, Andra; Harwood, Jeremy J; van Weeren, Reinout; Röttgering, Huub J A; Saunders, Richard D E; Sobral, David; Perrott, Yvette C; Schammel, Michel P

    2014-01-01

    We observed the cluster CIZA J2242.8+5301 with the Arcminute Microkelvin Imager at $16$ GHz and present the first high radio-frequency detection of diffuse, non-thermal cluster emission. This cluster hosts a variety of bright, extended, steep-spectrum synchrotron-emitting radio sources, associated with the intra-cluster medium, called radio relics. Most notably, the northern, Mpc-wide, narrow relic provides strong evidence for diffusive shock acceleration in clusters. We detect a puzzling, flat-spectrum, diffuse extension of the southern relic, which is not visible in the lower radio-frequency maps. The northern radio relic is unequivocally detected and measures an integrated flux of $1.2\\pm0.3$ mJy. While the low-frequency ($<2$ GHz) spectrum of the northern relic is well represented by a power-law, it clearly steepens towards $16$ GHz. This result is inconsistent with diffusive shock acceleration predictions of ageing plasma behind a uniform shock front. The steepening could be caused by an inhomogeneous...

  18. Impact of transfer for primary percutaneous coronary intervention on survival and clinical outcomes (from the HORIZONS-AMI Trial).

    NARCIS (Netherlands)

    Wohrle, J.; Desaga, M.; Metzger, C.; Huber, K.; Suryapranata, H.; Guetta, V.; Guagliumi, G.; Witzenbichler, B.; Parise, H.; Mehran, R.; Stone, G.W.

    2010-01-01

    Primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy in patients with ST-segment elevation myocardial infarction (STEMI). We evaluated whether presentation of patients with STEMI to a noninterventional facility requiring transfer for primary PCI compared to direct a

  19. Analysis, Modification, and Implementation (AMI) of Scheduling Algorithm for the IEEE 802.116e (Mobile WiMAX)

    CERN Document Server

    Ravichandiran, C; Vaidhyanathan, V

    2010-01-01

    Mobile WiMAX (Worldwide Interoperability for Microwave Access) is being touted as the most promising and potential broadband wireless technology. And the popularity rate has been surging to newer heights as the knowledge-backed service era unfolds steadily. Especially Mobile WiMAX is being projected as a real and strategic boon for developing counties such as India due to its wireless coverage acreage is phenomenally high. Mobile WiMAX has spurred tremendous interest from operators seeking to deploy high-performance yet cost-effective broadband wireless networks. The IEEE 802.16e standard based Mobile WiMAX system will be investigated for the purpose of Quality of Service provisioning. As a technical challenge, radio resource management will be primarily considered and main is the costly spectrum and the increasingly more demanding applications with ever growing number of subscribers. It is necessary to provide Quality of Service (QoS) guaranteed with different characteristics. As a possible solution the sche...

  20. Organoleptické defekty vína zpôsobené plesňami

    OpenAIRE

    Peško, Jakub

    2015-01-01

    This thesis dealt with the issue of an impact of mildew on wine quality. It clarifies the negative effects of mold which already occur in vineyard on grape bunches and the rest of the vine bush. It also explains that the mold is not getting into the wine only from mold infected grapes but also during the wine making and wine improving in cellar management. The thesis analyzes the characteristics and impacts of mold secondary metabolites and their wine quality affecting changes. It further des...

  1. Efficient and Privacy-Aware Power Injection over AMI and Smart Grid Slice in Future 5G Networks

    Directory of Open Access Journals (Sweden)

    Yinghui Zhang

    2017-01-01

    Full Text Available Smart grid is critical to the success of next generation of power grid, which is expected to be characterized by efficiency, cleanliness, security, and privacy. In this paper, aiming to tackle the security and privacy issues of power injection, we propose an efficient and privacy-aware power injection (EPPI scheme suitable for advanced metering infrastructure and 5G smart grid network slice. In EPPI, each power storage unit first blinds its power injection bid and then gives the blinded bid together with a signature to the local gateway. The gateway removes a partial blind factor from each blinded bid and then sends to the utility company aggregated bid and signature by using a novel aggregation technique called hash-then-addition. The utility company can get the total amount of collected power at each time slot by removing a blind factor from the aggregated bid. Throughout the EPPI system, both the gateway and the utility company cannot know individual bids and hence user privacy is preserved. In particular, EPPI allows the utility company to check the integrity and authenticity of the collected data. Finally, extensive evaluations indicate that EPPI is secure and privacy-aware and it is efficient in terms of computation and communication cost.

  2. La bohème, les amis. L’art jeune transylvain de l’entre-deux guerres

    Directory of Open Access Journals (Sweden)

    Ioana Vlasiu

    2011-01-01

    Full Text Available Les histoires de l’art roumain du XXe siecle ont privilégié plutôt l’art de Bucarest, de la capitale, où évidemment régnait une plus grande diversité et ampleur de la vie artistique, absentes ailleurs. Le jeune art de Cluj connaît dans les années ’30 un remarquable essor grâce à la fondation, ici, de l’Ecoles des beaux-arts en 1925, après l’Union de la Transylvanie au royaume de Roumanie à la suite de la première guerre mondiale. Autour des professeurs, eux mêmes tres jeunes – Catul Bogdan, Romul Ladea, Anastase Demian, Aurel Ciupe - des artistes des premières promotions, essaient dans des conditions peu propices de construire un climat artistique et d’affirmer une modernité qui ait ses traits caractéristiques et une certaine originalité par rapport à l’art bucarestois de la même époque.

  3. Bowen系统家庭的理论及治疗要点简介%Bowen System Family Theory and Therapeutic Main Points

    Institute of Scientific and Technical Information of China (English)

    易春丽; 钱铭怡; 章晓云

    2004-01-01

    @@ Murray Bowen是系统家庭理论的奠基人,他最初是精神分析取向的治疗师,20世纪40年代末以来,他在从事精神科临床工作中对家庭关系的作用产生了兴趣.随着20世纪50年代中期他对精神分裂症的家庭进行的深入的研究,Bowen的系统家庭理念逐渐完善.

  4. Expressions of bcl-2 and P53 protein in Bowen's disease%Bowen病bcl-2及P53蛋白的表达

    Institute of Scientific and Technical Information of China (English)

    张士发; 王良明; 赵丽萍; 许静; 顾绍裘

    2004-01-01

    目的:探讨bcl-2及P53蛋白在Bowen病及Bowen样鳞癌中的表达及其意义.方法:应用免疫组织化学技术对11例Bowen病及3例Bowen样鳞癌bcl-2和/或P53蛋白的表达进行了检测.结果:11例Bowen病中bcl-2蛋白阳性2例(18%),P53蛋白阳性3例(27%);3例Bowen样鳞癌均见bcl-2蛋白表达.Bowen病中bcl-2与P53蛋白表达显著正相关(r=0.769,P<0.05).结论:Bowen病中bcl-2蛋白表达与P53基因突变有关,并参与了Bowen病的进展及向Bowen样鳞癌的演变.

  5. 5-氨基酮戊酸光动力学疗法治疗Bowen病%Photodynamic Therapy of Bowen's Disease Using 5-Aminolevulinic Acid

    Institute of Scientific and Technical Information of China (English)

    王秀丽; 徐世正; 张春荣; 郑卫

    1999-01-01

    目的探讨5-氨基酮戊酸(ALA)光动力学疗法(PDT)治疗Bowen病的疗效.方法 5例Bowen病患者皮损发生于腹部及股部,面积3.2 cm×3.0 cm至4.5 cm×3.0 cm,均经病理组织学检查确诊.局部外用新鲜配制的20%ALA霜,3 h后用波长632.8 nm的He-Ne激光照射,激光机输出功率为100 mW,每次光剂量60~100 J/cm2,照射时间8~15 min.结果经1次(1例)和4次(4例)治疗后,患者皮损完全消退,恢复正常皮纹.随访6~16个月,未见复发.结论 ALA-PDT治疗Bowen病简单、有效、耐受性好,为大面积Bowen病的治疗提供了新思路.

  6. The Study of Two Psychotherapy Approaches (Rogers Self Theory and Ellis Rational Theory) in Improvement of Bowen Self-differentiation and Intimacy.

    Science.gov (United States)

    Yousefi, Naser; Kiani, Mohammad Ali

    2014-01-01

    To compare the effectiveness of rational, behavioral and emotive therapy (REBT) and person-centered therapy (PCT) on self-differentiation and intimacy among divorce clients. In quasi-experimental study, 42 divorce clients (both males and females) who presented to the Counsling Center of Sanandaj, Iran were sampled. They were categorized into three groups of PCT, REBT, and control group (each group contained 14 subjects). The recovery indices (dependent variables) employed were the subject of self-differentiation and intimacy, which were measured twice before and after intervention of Differentiation of Self Inventory-2 (DSI-2) and intimacy. The therapy involved 8 one-hour sessions. It was held twice a week and therapeutic effects were traced after 8 months. The results showed that REBT and PCT were effective on self-differentiation scale and intimacy. Also they were influential in recovery self-differentiation scale and intimacy follow up stage. REBT and PCT were effective on self-differentiation and its subscales (Emotional reactivity, "I" position, Emotional cut off and Fusion with other) and general intimacy. None.

  7. 重构职务专利归属制度%Ownership of Work Made for Hire YANG Bowen, QIU Min

    Institute of Scientific and Technical Information of China (English)

    杨博闻; 邱敏

    2013-01-01

    职务专利的归属立法关乎劳动者创造性的激励,对于我国实施创新驱动发展战略有着至关重要的作用。根据我国现行《专利法》,单位是职务专利的权利人;虽然该法律同时规定单位应当支付给发明、设计人一定的奖励或报酬,但对奖励和报酬的数额规定过低,这显然不利于劳动者创造性的激发。应当改革现有职务专利归属制度,综合平衡发明人利益、单位需求和专利效益最大化,赋予发明人部分专利权的同时,规定单位有发明人服务期间的排他使用权和发明人离职时的强制赎买权;同时,为了防止单位滥用自己作为雇主的优势地位损害发明人正当利益,应该对单位和发明人之间的约定加以限制。%The ownership of wok -made-for-hire makes a key point to inspire the employees ’ creativity.It’ s also sig-nificant for the implement of innovation -driven development strategy , which is determined on the Eighteenth National Con-gress of the CPC.According to the current patent law of the People's Republic of China , the entity that is granted the patent right shall award to the inventor or creator of a service invention -creation a reward and , upon the exploitation of the paten-ted invention-creation, shall award to the inventor or creator an appropriate remuneration based on the extent of exploita -tion and application and the economic benefits yielded.However , the amount of the award is too low to inspire the employ-ees’ creativity.The needs of employees have risen from high standard of living to self -fulfillment because of social devel-opment.So the law related should be reformed for the benefits of employees.That is to say, the employees should be enti-tled as part-owner of the patent.Meanwhile , to improve the efficiency of the use of patent , the entity ’ s right to apply the patent to production ought to be acknowledged.And when the inventor resigns , the entity can redeem his or her part , and become the only owner of the patent.

  8. Comments on 'On the estimation of overwater bowen ratio from sea-air temperature difference. Reply to: Hsu, S.A. - A relationship between the Bowen ratio and sea-air temperature difference under unstable conditions at sea. J. Phys. Oceanogr. Vol. 28; p. 2222-2226'

    Digital Repository Service at National Institute of Oceanography (India)

    Sadhuram, Y.; Murty, T.V.R.; Sarma, Y.V.B; Murty, V.S.N.

    stream_size 2 stream_content_type text/plain stream_name J_Phys_Oceanogr_31_1933.pdf.txt stream_source_info J_Phys_Oceanogr_31_1933.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  9. Optimal Throughput and Self-adaptability of Robust Real-Time IEEE 802.15.4 MAC for AMI Mesh Network

    Science.gov (United States)

    Shabani, Hikma; Mohamud Ahmed, Musse; Khan, Sheroz; Hameed, Shahab Ahmed; Hadi Habaebi, Mohamed

    2013-12-01

    A smart grid refers to a modernization of the electricity system that brings intelligence, reliability, efficiency and optimality to the power grid. To provide an automated and widely distributed energy delivery, the smart grid will be branded by a two-way flow of electricity and information system between energy suppliers and their customers. Thus, the smart grid is a power grid that integrates data communication networks which provide the collected and analysed data at all levels in real time. Therefore, the performance of communication systems is so vital for the success of smart grid. Merit to the ZigBee/IEEE802.15.4std low cost, low power, low data rate, short range, simplicity and free licensed spectrum that makes wireless sensor networks (WSNs) the most suitable wireless technology for smart grid applications. Unfortunately, almost all ZigBee channels overlap with wireless local area network (WLAN) channels, resulting in severe performance degradation due to interference. In order to improve the performance of communication systems, this paper proposes an optimal throughput and self-adaptability of ZigBee/IEEE802.15.4std for smart grid.

  10. Impact of different clinical pathways on outcomes of patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: the RAPID-AMI study

    Institute of Scientific and Technical Information of China (English)

    ZHANG Qi; ZHANG Rui-yan; QIU Jian-ping; JIN Hui-gen; ZHANG Jun-feng; WANG Xiao-long; JIANG Li; LIAO Min-lei; HU Jian; DING Feng-hua; ZHANG Jian-sheng; SHEN Wei-feng

    2009-01-01

    Background Current guidelines support primary percutaneous coronary intervention (primary PCI) as the first treatment of choice (as opposed to thrombolytic therapy) for patients with acute ST-segment elevation myocardial infarction (STEMI) especially when delivered within 12 hours of symptom onset. We aimed to evaluate the impact of different clinical pathways on reduction of reperfusion delay and subsequent improvement in outcomes in patients with STEMI.Methods From November 2005 to November 2007, 546 consecutive patients with definite STEMI, who upon arrival at the emergency room were triaged to undergo primary PCI, were included. Of them, 271 patients were brought directly to catheterization laboratory (rapid group), and 275 patients were admitted to the coronary care unit (CCU) or cardiac ward first, and then transferred to the catheterization laboratory (non-rapid group). Primary endpoint was door-to-balloon (D28) time, and secondary endpoints included infarct size assessed by peak CK-MB level and rates of major cardiac adverse events (MACE) including death, reinfarction, or target-vessel revascularization during hospitalization and at 30-day clinical follow-up.Results Baseline clinical characteristics, angiographic features and procedural success rates were comparable between the two groups, except that more patients received glycoprotein Ⅱb/Ⅲa receptor inhibitors before angiography (84.0% and 77.1, P=0.042) and had TIMI 3 flow in the culprit vessel at initial angiogram (17.1% and 9.2%, P=0.007) in the non-rapid group. The D2B time was shortened ((108±44) minutes and (138±31) minutes, P <0.0001), and number of patients with D2B time <90 minutes was greater (22.6% and 10.9%, P <0.0001) in the rapid group. The advantages associated with rapid intra-hospital transfer were enhanced if the patients presented to the hospital at regular hours. Peak CK-MB level was significantly reduced in the rapid group. In-hospital mortality (4.1% and 5.8%) and cumulative MACE rate (7.0% and 9.8%) did not significantly differ between rapid and non-rapid groups. At 30 days, cumulative death-and MACE-free survival rates were improved in the rapid group (94.5% and 89.5%, P=0.035; 90.1% and 84.0%, P=0.034, respectively).Conclusions Clinical pathway with bypass of CCU/cardiac ward admission was associated with rapid reperfusion, smaller infarct size, and improved short-term survival for patients with STEMI undergoing primary PCI. In the future, it is essential to reduce the time delay for patients presenting at off-hours.

  11. Use of podcast technology to facilitate education, communication and dissemination in palliative care: the development of the AmiPal podcast.

    Science.gov (United States)

    Nwosu, Amara Callistus; Monnery, Daniel; Reid, Victoria Louise; Chapman, Laura

    2017-06-01

    Podcasts have the potential to facilitate communication about palliative care with researchers, policymakers and the public. Some podcasts about palliative care are available; however, this is not reflected in the academic literature. Further study is needed to evaluate the utility of podcasts to facilitate knowledge-transfer about subjects related to palliative care. The aims of this paper are to (1) describe the development of a palliative care podcast according to international recommendations for podcast quality and (2) conduct an analysis of podcast listenership over a 14-month period. The podcast was designed according to internationally agreed quality indicators for medical education podcasts. The podcast was published on SoundCloud and was promoted via social media. Data were analysed for frequency of plays and geographical location between January 2015 and February 2016. 20 podcasts were developed which were listened to 3036 times (an average of 217 monthly plays). The Rich Site Summary feed was the most popular way to access the podcast (n=1937; 64%). The mean duration of each podcast was 10 min (range 3-21 min). The podcast was listened to in 68 different countries and was most popular in English-speaking areas, of which the USA (n=1372, 45.2%), UK (n=661, 21.8%) and Canada (n=221, 7.3%) were most common. A palliative care podcast is a method to facilitate palliative care discussion with global audience. Podcasts offer the potential to develop educational content and promote research dissemination. Future work should focus on content development, quality metrics and impact analysis, as this form of digital communication is likely to increase and engage wider society. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  12. NEYZEN TEVFİK (HIS LIFE, PERSONALITY AND WORKS NEYZEN TEVFİK (YAŞAMI, KİŞİLİĞİ VE ESERLERİ

    Directory of Open Access Journals (Sweden)

    Selman YAŞAR

    2010-07-01

    Full Text Available Neyzen Tevfik when was born in 1879 in Bodrum, has gained a fame with mastery in reed instrument. Neyzen Tevfik who has been accept for third satire artisan in our literature, has been published poem boks which named “Hiç” and “Azab-ı Mukaddes”, composed poems and records. Neyzen which write a article in the newspapers also has got a role in the films. Neyzen Tevfik who has personality which peculiar to himself, hasn’t attached importance to money, post and position, has distrubuted his gained to his surroundings. 1879 yılında Bodrum’da doğan Neyzen Tevfik ney enstrümanındaki ustalığı ile ün kazanmıştır. Edebiyatımızda Nef’i ve Eşref’ten sonra 3. büyük hiciv ustası olarak kabul edilen Neyzen Tevfik’in yayınlanan “Hiç” ve “Azab-ı Mukaddes” adlı şiir kitapları, bestelenmiş şiirleri ile plakları vardır. Gazetelerde yazılar yazan Neyzen filmlerde de rol almıştır. Kendine özgü bir kişiliği olan Neyzen Tevfik, paraya, makam ve mevkiye önem vermemiş, kazandıklarını çevresindekilere dağıtmıştır.

  13. Narrowband G3 Power Line Communication Technology and Its Application in AMI%窄带G3-PLC技术及其在AMI中应用探讨

    Institute of Scientific and Technical Information of China (English)

    陶维青; 余根; 刘明武; 杨镕旭

    2012-01-01

      随着智能电网技术的发展,传统的NB-PLC技术已经不能满足其不断增长的网络数据量和对安全性以及数据传输可靠性的要求,具有更高速率、更加强健、更加安全的NB-PLC技术必将成为未来发展的趋势.G3-PLC技术是新一代NB-PLC技术规范,规范定义了强健的物理层和基于IEEE 802.15.4的MAC层以及网络层、传输层和基于COSEM的应用层,是一个面向现在和未来的开放性NB-PLC规范.在对规范作了简要介绍基础上,探讨了该技术在智能电网AMI中的应用前景和方案.

  14. « Petits meurtres entre amis », Approche psychosomatique et psychodynamique du harcèlement moral au travail

    Directory of Open Access Journals (Sweden)

    Marie Grenier-Pezé

    2005-11-01

    Full Text Available La présence médiatique du harcèlement moral interroge sa légitimité sociale et psychopathologique. Comprendre la redoutable toxicité de la situation de harcèlement impose de se pencher sur les enjeux identitaires liés à la situation de travail. Il s’agit de replacer ce nouveau syndrome dans le contexte plus large des effets positifs et négatifs de l’organisation du travail sur la santé psychique et physique. Les mécanismes de défense individuels et les stratégies collectives mobilisés par les sujets pour tenir au travail peuvent souder ou disloquer un collectif de travail entraînant la désignation d’un bouc émissaire. L’intériorisation des valeurs organisationnelles de l’entreprise autorisent la banalisation du mal exercé sur autrui, sa systématisation en techniques de disciplinarisation du corps. La rencontre avec le réseau de prise en charge, médecin du travail, médecin inspecteur, médecin généraliste, psychologue n’est pas qu’une stratégie médico-administrative. Ce travail du lien met un terme symbolique à l’isolement du harcelé et un point d’arrêt à la désintrication psychosomatique en cours.The presence of moral harassment in the media questions its own social and psychopathological legitimacy. To understand the formidable toxicity of the harassment situation, identity issues related to the work situation need to be investigated. This new syndrome must be re-situated within the broader framework of the positive and negative effects of work organization on mental and physical health. The individual defence mechanisms and collective strategies that subjects mobilize to cope at work can either strengthen or dismantle a work collective, thus resulting in the creation of a scapegoat. Internalizing the company’s organizational values allows banalization of the harm imposed on others, and its systematization through bodily discipline techniques. Meeting with the network (the company medical officer, the government medical inspector, the general practitioner, the workplace psychologist is not just a medical and administrative strategy. This networking also puts a symbolic end to the harassed person’s isolation and an end to the evolving psychosomatic symptoms.La presencia mediática del acoso moral interroga su legitimidad social y psicopatológica. Comprender la temible toxicidad de la situación de acoso impone examinar lo que está en juego desde el punto de vista de la identidad en realción con la situación de trabajo. Se trata de reposicionar este nuevo síndrome en el contexto más amplio de los efectos positivos y negativos de la organización del trabajo sobre la salud psíquica y física. Los mecanismos de defensa individuales y las estrategias colectivas mobilizadas por los sujetos para mantenerse en el trabajo pueden solidificar o desmembrar un colectivo de trabajo ocasionando la designación de un chivo expiatorio. La interiorización de valores organizacionales de la empresa autoriza la banalización del mal ejercido contra el otro, su sistematización en técnicas cuyo objetivo es disciplinar el cuerpo. El encuentro con la red de contención, médico del trabajo, médico inspector, médico generalista, psicólogo no es solo una estrategia médico-administrativa. El trabajo sobre el vínculo pone un término simbólico al aislamiento del acosado y un freno a la desintricación psicosomática en curso.

  15. AMI 患者溶栓后发生再灌注心律失常的防治与护理

    Institute of Scientific and Technical Information of China (English)

    侯吉明

    2014-01-01

    reperfusion arrhythmia is the important pathogenesis of sudden cardiac death in patients with ,after thrombolytic therapy in acute myo-cardial infarction in recovery of patients with cardiac ischemia state blood perfusion during cardiac arrhythmias .Medical personnel closely monitoring ecg changes ,active prevention and control the occurrence of complications ;Heart function in patients with symptomatic treatment ,to safeguard ;Ac-tively improve the patient's blood supply ,symptomatic treatment ;Suit the medicine to ensure improve thrombolysis in patients with cure rate .%再灌注性心律失常是患者发生心脏性猝死的重要发病机制,常见于急性心肌梗死溶栓治疗后,处于心脏缺血状态的患者在恢复血流灌注过程中发生的心律失常。医护人员严密监护心电变化,积极预防与控制并发症的发生;对症治疗,保护好患者的心脏功能;积极改善患者血液供应,对症处理;对症用药,确保提高患者溶栓治愈率。本文入选的60例患者,急性心肌梗死溶栓后心律失常发病率42%,多发生在胸痛缓解、S T 段下移之后持续2-120min。其中,AIVR发病率占12.1%,BHS发病率占11.5%,新出现室早或室早增多发病率占9.8%,室颤发病率占5.3%。入选的60例患者,经过临床救治均康复出院。

  16. 右位心合并急性心肌梗死的临床心电图分析%Clinical ECG Analysis of Dextrocardia with AMI

    Institute of Scientific and Technical Information of China (English)

    贺茜影; 刘仁光; 王晓梅

    2016-01-01

    Dextrocardia with acute myocardial infarction is clinically rare.Based on the ECG analysis of a case of mirror-image dextrocardia with acute myocardial infarction, this paper discusses the electrocardiogram features of mirror-image dextrocardia, diag-nosis and differential diagnosis of complicated acute myocardial infarction and the related issues.%右位心合并急性心肌梗死临床上较为少见,本文结合1例镜像右位心合并急性心肌梗死的心电图分析,讨论镜像右位心的心电图特点,合并急性心肌梗死的诊断和鉴别诊断有关问题。

  17. PCI in AMI: concern and objective appraisal%急性心梗患者的介入治疗:考虑及客观评估

    Institute of Scientific and Technical Information of China (English)

    张建; 齐向前

    2010-01-01

    @@ 1 Stent thrombosis PCI has become the most frequently used method of myocardial revascularization:Within 2 years of being introduced,4.5 million DES were implanted worldwide,helping to treat 3 million patient.No permanent,implantable medical device has experienced such rapid market penetration and acceptance.

  18. A scientist born in amiens : jacques rohault (1620-1672) (French Title: Un savant amiénois : jacques rohault (1620-1672))

    Science.gov (United States)

    Le Boeuffle, A.

    2004-12-01

    Jacques Rohault is born in Amiens town at the beginning of the seventeen century. After the Middle Ages, science try to use nex methods and want to abandon Greek's dogmas. Rohault came to Paris to continue his studies and met J.B. Poquelin (Molière). He became a friend an a supporter of René Descartes. He was a very popular scientist. He practised many experiments in public and writed the book La physique to popularize science.

  19. Comparison of biolimus eluted from an erodible stent coating with bare metal stents in acute ST-elevation myocardial infarction (COMFORTABLE AMI trial): rationale and design

    NARCIS (Netherlands)

    Räber, L.; von Birgelen, Clemens

    2012-01-01

    Aims: Compared with bare metal stents (BMS), early generation drug-eluting stents (DES) reduce the risk of revascularisation in patients with ST-elevation myocardial infarction (STEMI) at the expense of an increased risk of very late stent thrombosis (ST). Durable polymer coatings for controlled

  20. National Assessment of Statin Therapy in Patients Hospitalized with Acute Myocardial Infarction: Insight from China PEACE-Retrospective AMI Study, 2001, 2006, 2011.

    Directory of Open Access Journals (Sweden)

    Lihua Zhang

    Full Text Available Statin therapy is among the most effective treatments to improve short- and long-term mortality after acute myocardial infarction. The use of statin, and the intensity of their use, has not been described in acute myocardial infarction patients in China, a country with a rapidly growing burden of cardiovascular disease.Using a nationally representative sample of patients with acute myocardial infarction admitted to 162 Chinese hospitals in 2001, 2006 and 2011, we identified 14,958 patients eligible for statin therapy to determine rates of statin use and the intensity of statin therapy, defined as those statin regimens with expected low-density lipoprotein cholesterol lowering of at least 40%, to identify factors associated with the use of statin therapy. Statin use among hospitalized patients with acute myocardial infarction increased from 27.9% in 2001 to 72.5% in 2006, and 88.8% in 2011 (P<0.001 for trend. Regional variation in statin use correspondingly decreased over time. Among treated patients, those receiving intensive statin therapy increased from 1.0% in 2001 to 24.2% in 2006 to 57.2% in 2011(P<0.001 for trend. Patients without low-density lipoprotein cholesterol measured were less likely to be treated with statin or to receive intensive therapy.The use of statin therapy has dramatically increased over the past decade in Chinese patients with acute myocardial infarction. However, half of patients still did not receive intensive statin therapy in 2011.Given that guidelines strongly endorse intensive statin therapy for acute myocardial infarction patients, initiatives promoting the use of statin therapy, with attention to treatment intensity, would support further improvements in practice.

  1. Assessing impacts of PBL and surface layer schemes in simulating the surface-atmosphere interactions and precipitation over the tropical ocean using observations from AMIE/DYNAMO

    Energy Technology Data Exchange (ETDEWEB)

    Qian, Yun; Yan, Huiping; Berg, Larry K.; Hagos, Samson M.; Feng, Zhe; Yang, Ben; Huang, Maoyi

    2016-11-01

    Accuracy of turbulence parameterization in representing Planetary Boundary Layer (PBL) processes in climate models is critical for predicting the initiation and development of clouds, air quality issues, and underlying surface-atmosphere-cloud interactions. In this study, we 1) evaluate WRF model-simulated spatial patterns of precipitation and surface fluxes, as well as vertical profiles of potential temperature, humidity, moist static energy and moisture tendency terms as simulated by WRF at various spatial resolutions and with PBL, surface layer and shallow convection schemes against measurements, 2) identify model biases by examining the moisture tendency terms contributed by PBL and convection processes through nudging experiments, and 3) evaluate the dependence of modeled surface latent heat (LH) fluxes onPBL and surface layer schemes over the tropical ocean. The results show that PBL and surface parameterizations have surprisingly large impacts on precipitation, convection initiation and surface moisture fluxes over tropical oceans. All of the parameterizations tested tend to overpredict moisture in PBL and free atmosphere, and consequently result in larger moist static energy and precipitation. Moisture nudging tends to suppress the initiation of convection and reduces the excess precipitation. The reduction in precipitation bias in turn reduces the surface wind and LH flux biases, which suggests that the model drifts at least partly because of a positive feedback between precipitation and surface fluxes. The updated shallow convection scheme KF-CuP tends to suppress the initiation and development of deep convection, consequently decreasing precipitation. The Eta surface layer scheme predicts more reasonable LH fluxes and the LH-Wind Speed relationship than the MM5 scheme, especially when coupled with the MYJ scheme. By examining various parameterization schemes in WRF, we identify sources of biases and weaknesses of current PBL, surface layer and shallow convection schemes in reproducing PBL processes, the initiation of convection and intra-seasonal variability of precipitation.

  2. Tendencias de la multialfabetización en los albores del siglo XXI: alfabetización mediática e informacional (AMI) como propuesta integradora

    OpenAIRE

    2015-01-01

    La evolución de alfabetismos se produjo como resultado de la transición de una cultura oral a una cultura letrada. El presente estudio examina las principales tendencias de la multialfabetización a principios del siglo XXI. Se combina el método de análisis documental y el método bibliométrico en el análisis de la evolución de los alfabetismos, a través de documentos que establecen pautas en su fundamentación y el comportamiento de la producción científica por año en la primera década del sigl...

  3. Design and implementation of a Smart Measurement System for AMI in the microgrid of the University of Nariño

    Directory of Open Access Journals (Sweden)

    Andrés F. Arciniegas M.

    2017-02-01

    Full Text Available This project describes a proposed Measure Management System, from the design stage to the implementation of a prototype smart meter, adapted to operate in the microgrid at the University of Nariño. This device features a constant record of measures, with resolution of 24 bits, sufficient to perform power quality analysis. In addition, it is integrated into the SCADA system through the open protocols MODBUS, DNP3 and IEC 61850, with scheduled cybersecurity techniques. Likewise, several management platforms for the monitoring of electrical variables and control over the current flow to the loads is designed. Finally, two study cases show the application of the implemented measure management system in the microgrid.

  4. Expression of bc1-2 and p53 Protein in Bowen's Disease%Bowen病bc1-2及p53蛋白的表达

    Institute of Scientific and Technical Information of China (English)

    曲长青; 张士发; 张素宁; 林俊萍; 王良明; 梁再赋; 冯永山; 许静; 顾绍裘

    2000-01-01

    目的:探讨bc1-2及p53蛋白在Bowen病及Bowen样鳞癌中的表达及其意义.方法:应用免疫组织化学技术对11例Bowen病及3例Bowen样鳞癌bc1-2和/或p53蛋白的表达进行了检测.结果:11例Bowen病bc1-2蛋白阳性者2例(18%),p53蛋白阳性者3例(27%);3例Bowen样鳞癌均见bc1-2蛋白表达.Bowen中bc1-2蛋白与p53蛋白表达呈显著正相关(r=0.769,P<0.05).结论:Bowen病中bc1-2蛋白的表达与p53基因突变有关,并参与了Bowen病的进展及向Bowen样鳞癌演变.

  5. Trouble dans la guerre : The Heat of the Day d’Elizabeth Bowen, un roman d’espionnage au féminin Gendered Double: Elizabeth Bowen’s The Heat of the Day, a Decentred Spy Story

    Directory of Open Access Journals (Sweden)

    Céline Magot

    2009-08-01

    Full Text Available The Second World War saw a radicalisation of gendered and social identities. In many ways, Elizabeth Bowen’s novel, The Heat of the Day renders the rising tensions of the period and reflects stereotypical visions of women as conveyed by male characters. But what may, at first, seem to be a conventional wartime spy novel in fact turns out to be a decentred version of the genre: by placing female characters at the centre of the plot, the traditional characteristics of the spy story become, in turn, feminised. The thematic and formal transformations are accentuated by laying the London plot side by side with the peace-land of a conservative Anglo-Irish world.

  6. Reading Elizabeth Bowen's "Demon Lover" in the Context of the Female Gothic%从女性哥特主义传统解读伊丽莎白·鲍恩的《魔鬼情人》

    Institute of Scientific and Technical Information of China (English)

    陈榕

    2006-01-01

    在这篇取材于英国民间歌谣的小说中,伊丽莎白·鲍恩对"魔鬼情人"这一文学原型进行了女性哥特主义改写,突出了男性迫害者对女性主体所构成的威胁,将男性暴力转化为对战争的隐喻.小说充斥着诡异迷离的气氛,细腻地描绘了挣扎在男性中心主义和战争双重阴影下的一位平凡女性的内心世界.小说开放的结局,增加了"魔鬼情人"形象的复义性.

  7. 皮肤磨削术联合光动力疗法治疗鲍恩病疗效观察%Clinical efficacy of dermabrasion combined with photodynamic therapy for the treatment of Bowen disease

    Institute of Scientific and Technical Information of China (English)

    羊剑秋

    2014-01-01

    目的:观察皮肤磨削术联合光动力疗法(PDT)治疗鲍恩病的临床疗效.方法:将门诊经组织病理诊断为鲍恩病的19例患者随机分为两组.联合治疗组:先进行肿瘤皮损的皮肤磨削术,术后外用5-氨基酮戊酸(ALA)溶液封包,5h后给予红光照射,波长635 nm,能量密度为100 J/cm2,照射20 min.14d后待创面愈合进行第2次,1周后进行第3次,3次为一个疗程,于1、2、3、6周及半年观察患者病灶局部反应.对照组:单用PDT,方法同联合治疗组,每周1次,3次为一个疗程.结果:联合治疗组治疗后,8例患者病灶完全缓解,2例患者病灶明显缩小>50%.对照组中5例完全缓解,3例部分缓解,1例无效.两组完全缓解率差异有统计学意义.结论:皮肤磨削术结合PDT可以作为鲍恩病治疗的一种新选择.

  8. 5-氨基酮戊酸光动力疗法(ALA-PDT)治疗Bowen病的临床分析%Clinical analysis of 5-aminolevulinic acid photodynamic therapy (ALA-PDT)in the treatment of Bowen disease

    Institute of Scientific and Technical Information of China (English)

    熊林; 张晓燕; 张文娟; 陆延娜; 周晓凤; 万静; 魏亚东

    2012-01-01

    目的 分析5-氨基酮戊酸(ALA)光动力学疗法(PDT)治疗Bowen病的临床近期效果.方法 选择经病理组织学检查确诊为Bowen病患者23例,随机分为治疗组12例和对照组11例.治疗组皮损处局部外用20%ALA霜,3h后行红光照射,剂量为(100~120)J/cm2,照射时间约20~30 min,4周内每周照射1次.对照组每日外用5-氟尿嘧啶软膏(5-FU软膏)2次,用药4周.比较两组患者的临床疗效.结果 治疗组完全有效率91.67%,总有效率100%;对照组完全有效率27.27%,总有效率90.91%.治疗组的完全有效率明显优于对照组,两组间差异有统计学意义(P<0.01).结论 ALA-PDT治疗Bowen病简单有效、耐受性好,且无严重副作用,值得临床推广.

  9. Geographical clustering of incident acute myocardial infarction in Denmark

    DEFF Research Database (Denmark)

    Kjærulff, Thora Majlund; Ersbøll, Annette Kjær; Gislason, Gunnar

    2016-01-01

    OBJECTIVES: To examine the geographical patterns in AMI and characterize individual and neighborhood sociodemographic factors for persons living inside versus outside AMI clusters. METHODS: The study population comprised 3,515,670 adults out of whom 74,126 persons experienced an incident AMI (200...... versus outside AMI clusters. CONCLUSIONS: AMI is geographically unequally distributed throughout Denmark and determinants of these geographical patterns might include individual- and neighborhood-level sociodemographic factors.......OBJECTIVES: To examine the geographical patterns in AMI and characterize individual and neighborhood sociodemographic factors for persons living inside versus outside AMI clusters. METHODS: The study population comprised 3,515,670 adults out of whom 74,126 persons experienced an incident AMI (2005......-2011). Kernel density estimation and global and local clustering methods were used to examine the geographical patterns in AMI. Median differences and frequency distributions of sociodemographic factors were calculated for persons living inside versus outside AMI clusters. RESULTS: Global clustering of AMI...

  10. Successful Management of a Patient with Refractory Ventricular Fibrillation (VF) due to Acute Myocardial Infarction (AMI) and Lung Injury by Transition from Percutaneous Cardiopulmonary Support (PCPS) to Veno-Venous Extracorporeal Membrane Oxygenation (ECMO).

    Science.gov (United States)

    Sato, Atsushi; Isoda, Kikuo; Gatate, Yodo; Akita, Koji; Daida, Hiroyuki

    2016-01-01

    A 69-year-old man was admitted to our hospital with cardiopulmonary arrest. Percutaneous cardio-pulmonary support (PCPS) using the right femoral artery and vein was initiated, because ventricular fibrillation continued. Although we succeeded in defibrillation after percutaneous coronary intervention (PCI), a chest radiograph indicated a pneumothorax in the right lung and a pulmonic contusion in the left lung caused by cardiopulmonary resuscitation. Two days after PCI, partial pressure of arterial oxygen (PaO2) from the right radial artery suddenly decreased, and his cardiac function showed improvement on an echocardiogram. To avoid additional brain damage, we converted the treatment to veno-venous extracorporeal membrane oxygenation by changing the blood returning site of PCPS from the right femoral artery to the right jugular vein. Thereafter, the patient's PaO2 level gradually improved.

  11. Analysis of Efficiency of Drilling of Large-Diameter Wells With a Profiled Wing Bit / Badania Efektywności Wiercenia Studni Wielkośrednicowych Świdrem Skrawającym z Profilowanymi Skrzydłami

    Science.gov (United States)

    Macuda, Jan

    2012-11-01

    In Poland all lignite mines are dewatered with the use of large-diameter wells. Drilling of such wells is inefficient owing to the presence of loose Quaternary and Tertiary material and considerable dewatering of rock mass within the open pit area. Difficult geological conditions significantly elongate the time in which large-diameter dewatering wells are drilled, and various drilling complications and break-downs related to the caving may occur. Obtaining higher drilling rates in large-diameter wells can be achieved only when new cutter bits designs are worked out and rock drillability tests performed for optimum mechanical parameters of drilling technology. Those tests were performed for a bit ø 1.16 m in separated macroscopically homogeneous layers of similar drillability. Depending on the designed thickness of the drilled layer, there were determined measurement sections from 0.2 to 1.0 m long, and each of the sections was drilled at constant rotary speed and weight on bit values. Prior to drillability tests, accounting for the technical characteristic of the rig and strength of the string and the cutter bit, there were established limitations for mechanical parameters of drilling technology: P ∈ (Pmin; Pmax) n ∈ (nmin; nmax) where: Pmin; Pmax - lowest and highest values of weight on bit, nmin; nmax - lowest and highest values of rotary speed of bit, For finding the dependence of the rate of penetration on weight on bit and rotary speed of bit various regression models have been analyzed. The most satisfactory results were obtained for the exponential model illustrating the influence of weight on bit and rotary speed of bit on drilling rate. The regression coefficients and statistical parameters prove the good fit of the model to measurement data, presented in tables 4-6. The average drilling rate for a cutter bit with profiled wings has been described with the form: Vśr= Z ·Pa· nb where: Vśr- average drilling rate, Z - drillability coefficient, P - weight on bit, n - rotary speed of bit, a - coefficient of influence of weight on bit on drilling rate, b - coefficient of influence of rotary speed of bit on drilling rate. Industrial tests were performed for assessing the efficiency of drilling of large-diameter wells with a cutter bit having profiled wings ø 1.16 m according to elaborated model of average rate of drilling. The obtained values of average rate of drilling during industrial tests ranged from 8.33×10-4 to 1.94×10-3 m/s and were higher than the ones obtained so far, i.e. from 181.21 to 262.11%.

  12. The validation of GRACE risk model in AMI patients around Soochow area%GRACE风险评分系统在苏州地区急性心肌梗死患者中的验证研究

    Institute of Scientific and Technical Information of China (English)

    韩良富; 卞晓洁; 郭艳霞; 陆士奇

    2015-01-01

    Objective To validate the GRACE risk score system of STEMI and NSTEMI in Soochow area .Methods A total of 312 patients with STEMI and NSTEMI were identified and the GRACE risk score were calculated for each patient .The validity of the model was assessed with discrimination , calibration and decision curve analysis .Results GRACE risk score demonstrated good discrimination (C-index 0.720, 95%CI 0.607~0.833).The calibration plot demonstrated that the risk was underestimated for low risk cohorts .Decision curve analysis showed that GRACE risk score system was suitable for all the patients enrolled in the validation cohorts .Conclusion GRACE risk score could make a good risk stratification of ACS subgroup ( STEMI and NSTEMI ) in Soochow area . Furthermore it was beneficial for stratifying , making individualized treatment and improving the prognosis.At present, the calibration ability of GRACE risk score system should be improved , validating with larger sample size of the risk stratification system is necessary .%目的 在苏州地区急性ST段抬高性心肌梗死( ST elevation myocardial infarction , STEMI)和急性非ST段抬高性心肌梗死(non-ST elevation myocardial infarction , NSTEMI)患者中外部验证GRACE风险评分系统. 方法 收集312 例STEMI和NSTEMI患者,计算每个患者的GRACE风险评分,通过区分、校准和决策曲线分析评估该模型的有效性. 结果 GRACE风险评分系统在苏州地区STEMI和NSTEMI患者中有着良好的区分度(C-index 0.720,95%CI 0.607~0.833). 校准曲线提示,低风险人群的风险被低估. 决策曲线分析表明, GRACE风险评分对验证人群的所有患者均适用. 结论 GRACE风险评分系统对苏州急性冠脉综合征( ACS)中STEMI和NSTEMI亚组能够进行较好地风险分层,有助于患者进行相对精确的风险分层,制定个体化的治疗方案,改善患者预后. 目前,GRACE风险评分系统的辨别能力还有待改进,需要更大样本量的研究或校准的风险分层评分系统问世.

  13. Estudio para la implementación del sistema de Infraestructura de Medición Avanzada (AMI) en la Empresa Eléctrica Regional Centro Sur C.A.

    OpenAIRE

    Coronel Gutiérrez, Marco Vinicio

    2011-01-01

    El concepto de eficiencia energética ha tomado fuerza en los últimos años, siendo un tema difundido y utilizado a nivel mundial en todo ámbito, incluyendo al sector de las empresas eléctricas dedicadas al negocio de la distribución de electricidad. Esta situación, despertó mi interés por este tema de tesis, que reconociendo la tendencia establecida de proponer un manejo más inteligente y adecuado de los activos de la red eléctrica, se pretende llevar la gestión de la cadena del suministro de ...

  14. 肯尼迪病与肌萎缩侧索硬化的临床及电生理特点比较%Comparison of clinical and physiological characteristics between Kennedy disease and amy-otrophic lateral sclerosis

    Institute of Scientific and Technical Information of China (English)

    杨嘉玲; 王群; 林丽珍; 王冬梅; 郑卉; 管玉青

    2014-01-01

    目的:分析肯尼迪病(Kennedy disease, KD)的临床特点,比较KD与肌萎缩侧索硬化(amyotrophic lateral sclerosis, ALS)的神经电生理改变。方法收集KD患者9例、ALS患者13例及正常对照26例,分析KD患者的临床表现,并对3组受试者的运动和感觉神经传导及常规肌电图结果进行统计分析。结果(1)KD组早中期舌肌萎缩、面肌束颤发生率分别为100%、88.9%;(2)KD组腓肠神经感觉神经动作电位(sensory nerve action potential, SNAP)未引出率56.3%,其波幅(7.9.±3.4)μV显著低于ALS组(20.0±5.2)μV及正常对照组(26.1±16.8)μV(P<0.05)。结论对于临床表现类似运动神经元病的男性患者,若早中期出现舌肌萎缩、面肌束颤,电生理检查有助于KD与ALS的鉴别诊断,腓肠神经SNAP波幅显著降低提示患者需行KD基因检查。%Objective To study the clinical presentations of Kennedy disease (KD) and compare the neurophysiological features between KD and amyotrophic lateral sclerosis(ALS). Methods Nine patients with KD, 13 patients with ALS and 26 normal control subjects were recruited. The clinical presentations of KD were analyzed, and the results of nerve conduction studies and electromyography were compared among the 3 groups. Results The rates of tongue atrophy and facial fasciculation were 100% and 88.9%, respectively, in the early course and mid-course of KD, sensory damages might be perceived. 2)The sural nerve sensory nerve action potential (SNAP) was not elicited in 56.3% of the patients with KD, and sural nerve SNAP amplitudes were significantly lower in KD (7.9±3.4μV) than in ALS patients (20.0±5.2μV) and normal control subjects (26.1± 16.8 μV) (P<0.05). Conclusion The onset of clinical presentations mimicking motor neuron disease, appearance of tongue atrophy and facial fasciculation in the early and mid-course, and presence of sensory impairment with a decreased sural nerve SNAP amplitude may suggest the diagnosis of KD and should prompt a genetic test for KD.

  15. 美托洛尔对心肌梗死后心力衰竭的疗效观察%The Effects of Metoprolol Therapy in the Patients of Acute Myocardial Infarction (AMI) with Cardiac Dysfunction

    Institute of Scientific and Technical Information of China (English)

    何建平; 伍蓓影

    2002-01-01

    目的探讨美托洛尔对心肌梗死后心力衰竭的临床疗效. 方法将132例同期心肌梗死后心力衰竭患者分为2组,观察组66例在常规治疗基础上加用美托洛尔治疗.观察心率、血压、心功能及副作用发生率,并作近期预后比较,对存活者定期行超声心动图测定左室收缩末期内径(LVIDs)、左室舒张末期内径(LVIDd)和左室射血分数(LVEF).对照组66例予常规治疗. 结果观察组治疗期间心率、血压均下降,心功能明显改善,2组近期预后比较,观察组梗死后心绞痛的发生率和住院病死率明显低于对照组,LVIDs、LVIDd和LVEF较对照组明显改善,观察组效果明显优于对照组,差异有显著意义(p<0.05).本组无因美托洛尔的副作用而停药者. 结论美托洛尔治疗心肌梗死后心力衰竭效果良好、安全.

  16. Comparison of Identify-Friend-Foe and Blue-Force Tracking Decision Support for Combat Identification (Comparaison des Systemes d’aide a la Decision Identification ami ou Ennemi et Suivi des Forces Bleues pour l’Identification au Combat)

    Science.gov (United States)

    2011-02-01

    conditions opérationnelles normales, les intempéries, la poussière et d’autres facteurs environnementaux peuvent nuire au fonctionnement des...dispositifs d’IAE et de SFB, il est essentiel d’examiner plus en profondeur l’influence des facteurs qui réduisent l’efficacité de ces appareils sur le...detected in the battlespace based on all available sources of data. Ultimately, the purpose of CID is to gain the maximal combat effectiveness possible

  17. An Analysis of Martin Amis's Yellow Dog from the Perspective of Postmodern Realism%后现代现实主义:解读马丁·艾米斯的小说《黄狗》

    Institute of Scientific and Technical Information of China (English)

    周庭华

    2010-01-01

    在饱受争议的小说中,马丁·艾米斯超越了现实主义和后现代主义的内在矛盾.他用现实主义手法表现了后现代社会的不安定感,表达了深刻的人文和道德关怀.后现代主义不仅仅是炫目的小说技巧,也是对影像和信息时代人类生存状况的本质反映.面对后现代社会真假杂糅、道德缺失的现状,艾米斯一面揭开丑恶和病态的根源,一面大声呼唤良知和真爱,使得这部作品在辛辣嘲讽的同时带有一股浓厚的道德劝谕的味道.

  18. CMR Native T1 Mapping Allows Differentiation of Reversible Versus Irreversible Myocardial Damage in ST-Segment-Elevation Myocardial Infarction: An OxAMI Study (Oxford Acute Myocardial Infarction).

    Science.gov (United States)

    Liu, Dan; Borlotti, Alessandra; Viliani, Dafne; Jerosch-Herold, Michael; Alkhalil, Mohammad; De Maria, Giovanni Luigi; Fahrni, Gregor; Dawkins, Sam; Wijesurendra, Rohan; Francis, Jane; Ferreira, Vanessa; Piechnik, Stefan; Robson, Matthew D; Banning, Adrian; Choudhury, Robin; Neubauer, Stefan; Channon, Keith; Kharbanda, Rajesh; Dall'Armellina, Erica

    2017-08-01

    CMR T1 mapping is a quantitative imaging technique allowing the assessment of myocardial injury early after ST-segment-elevation myocardial infarction. We sought to investigate the ability of acute native T1 mapping to differentiate reversible and irreversible myocardial injury and its predictive value for left ventricular remodeling. Sixty ST-segment-elevation myocardial infarction patients underwent acute and 6-month 3T CMR, including cine, T2-weighted (T2W) imaging, native shortened modified look-locker inversion recovery T1 mapping, rest first pass perfusion, and late gadolinium enhancement. T1 cutoff values for oedematous versus necrotic myocardium were identified as 1251 ms and 1400 ms, respectively, with prediction accuracy of 96.7% (95% confidence interval, 82.8% to 99.9%). Using the proposed threshold of 1400 ms, the volume of irreversibly damaged tissue was in good agreement with the 6-month late gadolinium enhancement volume (r=0.99) and correlated strongly with the log area under the curve troponin (r=0.80) and strongly with 6-month ejection fraction (r=-0.73). Acute T1 values were a strong predictor of 6-month wall thickening compared with late gadolinium enhancement. Acute native shortened modified look-locker inversion recovery T1 mapping differentiates reversible and irreversible myocardial injury, and it is a strong predictor of left ventricular remodeling in ST-segment-elevation myocardial infarction. A single CMR acquisition of native T1 mapping could potentially represent a fast, safe, and accurate method for early stratification of acute patients in need of more aggressive treatment. Further confirmatory studies will be needed. © 2017 The Authors.

  19. 磷酸肌酸钠在治疗急性心梗的作用%The Role of Creatine Phosphate Sodium in the Treatment of Acute Myocar-dial Infarction (ami)

    Institute of Scientific and Technical Information of China (English)

    王庆奎; 李永东

    2015-01-01

    磷酸肌酸为人体内的一类能量供应商,可以为各个组织提供能量支持。磷酸肌酸钠为一种商业化磷酸肌酸药物,近年来在急性心肌梗死中的应用越来越广泛,并取得良好的效果。该文将综述磷酸肌酸的作用、磷酸肌酸钠的作用机制及其应用进展,为磷酸肌酸钠的进一步临床应用提供参考。%the creatine phosphate is the body of energy suppliers, can provide energy support to various organizations. Creatine phosphate sodium for a commercial, creatine phosphate drugs application in acute myocardial infarction in recent years, more and more widely, and achieved good effect. This article will review the effect of creatine phosphate, sodium phosphocreatine, action mechanism and application of progress for sodium phosphocreatine can provide reference for clinical application.

  20. 中国心肌梗塞康复程序参考方案(第四版试行稿)%Reference scheme of Chinese program for AMI cardiac rehabilitation(forth edition)

    Institute of Scientific and Technical Information of China (English)

    中国康复医学会心血管病专业委员会; 心血管康复医学杂志编委会

    2006-01-01

    急性心肌梗塞(AMI)传统疗法的卧床休息时间、住院时间过长。目前我国多数医院AMI的严格卧床休息时间仍为1~2周。Wenger于本世纪60年代首先提出系统的康复程序,主张早活动、早下床、早出院。随后接受AMI康复医疗的患者住院时间由4周逐步缩短至2周,甚至有的无合并症患者已缩短至7天,而合并症并无增加;脑力劳动者于AMI发病后7周可恢复工作。患者早期回归家庭、社会,减轻了家庭、社会的负担,无疑有重大的社会意义和经济效益。1986年曲镭等在我国首先发表了AMI的康复医疗报告。同年,孙雨明等报告了心脏手术后的康复医疗。

  1. 商议民主的教育理论——埃米·古特曼的民主教育思想简析%The Educational Theory of Deliberative Democracy: Analyzing Amy Gutmann's Thought of Democratic Education

    Institute of Scientific and Technical Information of China (English)

    杨立峰

    2007-01-01

    埃米·古特曼是美国当代著名政治理论家,她提出的民主教育思想影响非常广泛.文章对她的这一思想进行了介绍和分析,把其定性为一种商议民主的教育理论,并把其主要内容总结为三个方面.最后,简要分析了她的理论对于我国当前教育问题的借鉴意义.

  2. Utility of peak creatine kinase-MB measurements in predicting myocardial infarct size, left ventricular dysfunction, and outcome after first anterior wall acute myocardial infarction (from the INFUSE-AMI trial).

    Science.gov (United States)

    Dohi, Tomotaka; Maehara, Akiko; Brener, Sorin J; Généreux, Philippe; Gershlick, Anthony H; Mehran, Roxana; Gibson, C Michael; Mintz, Gary S; Stone, Gregg W

    2015-03-01

    Infarct size after ST-segment elevation myocardial infarction (STEMI) is associated with long-term clinical outcomes. However, there is insufficient information correlating creatine kinase-MB (CK-MB) or troponin levels to infarct size and infarct location in first-time occurrence of STEMI. We, therefore, assessed the utility of CK-MB measurements after primary percutaneous coronary intervention of a first anterior STEMI using bivalirudin anticoagulation in patients who were randomized to intralesion abciximab versus no abciximab and to manual thrombus aspiration versus no aspiration. Infarct size (as a percentage of total left ventricular [LV] mass) and LV ejection fraction (LVEF) were evaluated by cardiac magnetic resonance imaging at 30 days and correlated to peak CK-MB. Peak CK-MB (median 240 IU/L; interquartile range 126 to 414) was significantly associated with infarct size and with LVEF (r = 0.67, p MB tertile group than in the other tertiles (87.6% vs 49.5% vs 9.1%, p MB of at least 300 IU/L predicted with moderate accuracy both a large infarct size (area under the curve 0.88) and an LVEF ≤40% (area under the curve 0.78). Furthermore, CK-MB was an independent predictor of 1-year major adverse cardiac events (hazard ratio 1.42 per each additional 100 IU/L [1.20 to 1.67], p MB measurement is useful in estimating infarct size and LVEF and in predicting 1-year clinical outcomes after primary percutaneous coronary intervention for first anterior STEMI. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Cost-effectiveness of high-sensitive troponin assays for the early rule-out or diagnosis of acute myocardial infarction (AMI) in people with acute chest pain : A nice diagnostic assessment

    NARCIS (Netherlands)

    Ramaekers, B.L.T.; Armstrong, N.; Joore, M.A.; Westwood, M.; Whiting, P.; Thokala, P.; Ross, J.; Kleijnen, J.; Severens, J.; Van Asselt, A.

    2014-01-01

    Objectives: To assess cost-effectiveness of high sensitivity troponin (hs-cTn) assays for the management of adults presenting with acute chest pain at the emergency department. Methods: An economic model was constructed to estimate lifetime costs and QALYs of five hs-cTn strategies (differing accord

  4. Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach.

    Science.gov (United States)

    Bonnefond, Amélie; Yengo, Loïc; Dechaume, Aurélie; Canouil, Mickaël; Castelain, Maxime; Roger, Estelle; Allegaert, Frédéric; Caiazzo, Robert; Raverdy, Violeta; Pigeyre, Marie; Arredouani, Abdelilah; Borys, Jean-Michel; Lévy-Marchal, Claire; Weill, Jacques; Roussel, Ronan; Balkau, Beverley; Marre, Michel; Pattou, François; Brousseau, Thierry; Froguel, Philippe

    2017-02-23

    Salivary (AMY1) and pancreatic (AMY2) amylases hydrolyze starch. Copy number of AMY1A (encoding AMY1) was reported to be higher in populations with a high-starch diet and reduced in obese people. These results based on quantitative PCR have been challenged recently. We aimed to re-assess the relationship between amylase and adiposity using a systems biology approach. We assessed the association between plasma enzymatic activity of AMY1 or AMY2, and several metabolic traits in almost 4000 French individuals from D.E.S.I.R. longitudinal study. The effect of the number of copies of AMY1A (encoding AMY1) or AMY2A (encoding AMY2) measured through droplet digital PCR was then analyzed on the same parameters in the same study. A Mendelian randomization analysis was also performed. We subsequently assessed the association between AMY1A copy number and obesity risk in two case-control studies (5000 samples in total). Finally, we assessed the association between body mass index (BMI)-related plasma metabolites and AMY1 or AMY2 activity. We evidenced strong associations between AMY1 or AMY2 activity and lower BMI. However, we found a modest contribution of AMY1A copy number to lower BMI. Mendelian randomization identified a causal negative effect of BMI on AMY1 and AMY2 activities. Yet, we also found a significant negative contribution of AMY1 activity at baseline to the change in BMI during the 9-year follow-up, and a significant contribution of AMY1A copy number to lower obesity risk in children, suggesting a bidirectional relationship between AMY1 activity and adiposity. Metabonomics identified a BMI-independent association between AMY1 activity and lactate, a product of complex carbohydrate fermentation. These findings provide new insights into the involvement of amylase in adiposity and starch metabolism.

  5. 25 LIPID PROFILE OF ADULT NIGERIANS ATTENDING MEDICAL ...

    African Journals Online (AJOL)

    2010-12-01

    Dec 1, 2010 ... *Department of Family Medicine, Baptist Medical Centre (now Bowen University. Teaching Hospital) ... Background: Economic development ... abdominal obesity among adults attending the ... prevalence of abdominal obesity.

  6. Insights into the "pair of sugar tongs" surface binding site in barley alpha-amylase isozymes and crystallization of appropriate sugar tongs mutants

    DEFF Research Database (Denmark)

    Tranier, S.; Deville, K.; Robert, X.

    2005-01-01

    Recently, the three-dimensional structure of AMY1 in complex with a thio-maltotetraose (thio-DP4) has contributed to the understanding of the isozyme differences between AMY1 and AMY2, particularly the higher activity of AMY1 on starch granules. Indeed, this structure reveals the presence of an a...

  7. Interactions of barley alpha-amylase isozymes with Ca2+, substrates and proteinaceous inhibitors

    DEFF Research Database (Denmark)

    Abou Hachem, Maher; Bozonnet, Sophie; Willemoes, Martin

    2006-01-01

    discovered 'sugar tongs' site in domain C of AMY1 is thus critical for binding to starch granules. Furthermore, mutations of binding sites mostly reduced the degree of multiple attack in amylose hydrolysis. AMY1 has higher substrate affinity than AMY2, but isozyme chimeras with AMY2 domain C and other...

  8. Insights into the "pair of sugar tongs" surface binding site in barley alpha-amylase isozymes and crystallization of appropriate sugar tongs mutants

    DEFF Research Database (Denmark)

    Tranier, S.; Deville, K.; Robert, X.

    2005-01-01

    Recently, the three-dimensional structure of AMY1 in complex with a thio-maltotetraose (thio-DP4) has contributed to the understanding of the isozyme differences between AMY1 and AMY2, particularly the higher activity of AMY1 on starch granules. Indeed, this structure reveals the presence of an a...

  9. Physical Activity in the Life of a Woman with Severe Cerebral Palsy: Showing Competence and Being Socially Connected

    Science.gov (United States)

    Gaskin, Cadeyrn J.; Andersen, Mark B.; Morris, Tony

    2009-01-01

    We used a life-history approach to investigate the meanings and experiences of physical activity in the life of a 25-year-old woman with severe cerebral palsy (Amy). Amy and her mother were interviewed about Amy's life and her involvement in physical activity. The conversation was audio-recorded and transcribed verbatim. We interpreted Amy's story…

  10. Catalytic properties of two Rhizopus oryzae 99-880 glucoamylase enzymes without starch binding domains expressed in Pichia pastoris

    Science.gov (United States)

    Catalytic properties of the two glucoamylases, AmyC and AmyD, without starch binding domains from Rhizopus oryzae strain 99-880 were heterologously expressed and purified to homogeneity. AmyC and AmyD demonstrate pH optima of 5.5 and 6.0, respectively, nearly 1 unit higher than most fungal glucoamy...

  11. Comparisons of Copy Number, Genomic Structure, and Conserved Motifs for α-Amylase Genes from Barley, Rice, and Wheat

    Directory of Open Access Journals (Sweden)

    Qisen Zhang

    2017-10-01

    Full Text Available Barley is an important crop for the production of malt and beer. However, crops such as rice and wheat are rarely used for malting. α-amylase is the key enzyme that degrades starch during malting. In this study, we compared the genomic properties, gene copies, and conserved promoter motifs of α-amylase genes in barley, rice, and wheat. In all three crops, α-amylase consists of four subfamilies designated amy1, amy2, amy3, and amy4. In wheat and barley, members of amy1 and amy2 genes are localized on chromosomes 6 and 7, respectively. In rice, members of amy1 genes are found on chromosomes 1 and 2, and amy2 genes on chromosome 6. The barley genome has six amy1 members and three amy2 members. The wheat B genome contains four amy1 members and three amy2 members, while the rice genome has three amy1 members and one amy2 member. The B genome has mostly amy1 and amy2 members among the three wheat genomes. Amy1 promoters from all three crop genomes contain a GA-responsive complex consisting of a GA-responsive element (CAATAAA, pyrimidine box (CCTTTT and TATCCAT/C box. This study has shown that amy1 and amy2 from both wheat and barley have similar genomic properties, including exon/intron structures and GA-responsive elements on promoters, but these differ in rice. Like barley, wheat should have sufficient amy activity to degrade starch completely during malting. Other factors, such as high protein with haze issues and the lack of husk causing Lauting difficulty, may limit the use of wheat for brewing.

  12. Getting the HR message across: The linkage between line HR consensus and commitment strength among hospital employees

    NARCIS (Netherlands)

    Dorenbosch, Luc; Reuver, Renee; Sanders, Karin

    2006-01-01

    Related to the theoretical work of Bowen and Ostroff (2004; also Ostroff/Bowen 2000), this article focuses on the features of an HRM system that help or constrain organizations to get their HR message across. At a department-level of analysis, we focus on the consensus between line managers and

  13. Getting the HR message across: The linkage between line HR consensus and commitment strength among hospital employees

    NARCIS (Netherlands)

    Dorenbosch, Luc; Reuver, Renee; Sanders, Karin

    2006-01-01

    Related to the theoretical work of Bowen and Ostroff (2004; also Ostroff/Bowen 2000), this article focuses on the features of an HRM system that help or constrain organizations to get their HR message across. At a department-level of analysis, we focus on the consensus between line managers and dece

  14. Increasing Small Arms Lethality in Afghanistan Taking Back the Infantry Half-Kilometer

    Science.gov (United States)

    2009-05-21

    John A. Malinowski , and Robert E. Bowen. "Bullet Fragmentation: A Major Cause of Tissue Disruption." JTrauma, 1984: 35-39. 67 Initial muzzle...Fackler, Martin L, M.D., M.A. John S. Surinchak, B.S. John A. Malinowski , and Robert E. Bowen. "Bullet Fragmentation: A Major Cause of Tissue

  15. Viewing Aging Issues From a Family Theory and Therapy Perspective.

    Science.gov (United States)

    Kerr, Kathleen B.

    When applied to older persons, basic concepts of Bowen Family Systems Theory, the most well developed theory emerging from the family movement in psychiatry, focus on the family systems of older people rather than on the problems of the aged. This Bowen focus on the value of intergenerational contact and continuity leads naturally to seeing the…

  16. Getting the HR Message Across: The Linkage between Line - HR Consensus and "Commitment Strength" among Hospital Employees

    NARCIS (Netherlands)

    Dorenbosch, Luc; Reuver, Renee; Sanders, Karin

    2006-01-01

    Related to the theoretical work of Bowen and Ostroff (2004; also Ostroff/Bowen 2000), this article focuses on the features of an HRM system that help or constrain organizations to get their HR message across. At a department-level of analysis, we focus on the consensus between line managers and dece

  17. Oscillatory infragravity wave contribution to surf zone sediment transport

    DEFF Research Database (Denmark)

    Aagaard, Troels; Greenwood, Brian

    2008-01-01

    can create a perturbation of the bar crest and/or generate a crescentic bar. These results provide support for the template model for crescentic bar formation, first proposed by Bowen and Inman (Bowen, A.J. and Inman, D.L., 1971. Edge waves and crescentic bars. J.Geophys.Res., 76, 8662-8670) although...

  18. 77 FR 23203 - Radio Broadcasting Services; Summit, MS

    Science.gov (United States)

    2012-04-18

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Summit, MS AGENCY: Federal Communications Commission.... The Commission requests comment on a petition filed by Bowen Broadcasting, proposing to amend the...., Officer, Bowen Broadcasting, 1125 Petrified Forest Road, Flora, Mississippi 39071. FOR FURTHER...

  19. Differentiation of Self, Personal Adjustment, Problem Solving, and Ethnic Group Belonging among Persons of Color.

    Science.gov (United States)

    Skowron, Elizabeth A.

    2004-01-01

    This study focused on examining the cross-cultural validity of Bowen family systems theory (M. Bowen, 1978), namely differentiation of self for individuals of color. Ethnic minority men and women completed measures of differentiation of self, ethnic group belonging, and 3 indices of personal adjustment. Initial support for the cross-cultural…

  20. Spousal depression, anxiety, and suicide after myocardial infarction

    DEFF Research Database (Denmark)

    Fosbøl, Emil Loldrup; Peterson, Eric D; Weeke, Peter

    2013-01-01

    or non-fatal AMI. Married patients with fatal or non-fatal AMI (1997-2008) were matched with their counterparts dying or hospitalized with a non-AMI cause; incident use of antidepressants and benzodiazepines, incident depression care, and suicides were compared pre- and post-event using Poisson models....... Overall, 16 506 spouses of individuals dying of AMI were matched with 49 518 spouses of individuals dying of a non-AMI cause. Similarly, 44 566 spouses of individuals with a non-fatal AMI were matched with 131 563 spouses of individuals with a non-fatal, non-AMI hospitalization. Those whose spouse died...... of AMI (compared with a non-AMI cause) had increased antidepressant and benzodiazepine use [peak incidence rate ratio (IRR) 5.7 vs. 3.3, and 46.4 vs. 13.0, respectively; P

  1. 从历史语篇分析的角度来解读刘志军贪腐案的微博博文%From the analysis of historical discourse perspective to see Liu Zhi-jun corruption case micro-blog Bowen

    Institute of Scientific and Technical Information of China (English)

    王涵

    2014-01-01

    语篇历史方法是Ruth Wodak和她领导的研究小组进行语篇研究的一种方法。本文以语言学家Ruth Wodak的话语历史分析为理论框架,结合互文性理论的分析,选取新浪微博和腾讯微博有关原铁道部部长刘志军贪腐案的热门报道共60篇样本,通过分析刘志军贪腐案相关的微博语篇,把潜藏在微博语篇之下的网络民众对于官员贪腐的批判性意识形态显现出来,进一步体现人们的话语权意识在不知不觉中被唤醒,民众更加独立地发表自己的观点,通过微博语篇表达自己的话语权力。%Discourse historical approach is textual research method of Ruth Wodak and her team. In this paper, linguist Ruth Wodak discourse historical analysis of the theoretical framework, combined with the analysis of the theory of intertextuality, popular reports selected micro-blog Sina and Tencent micro-blog about formerrailways minister Liu Zhijun corruption case of a total of 60 samples, through the analysis of Liu Zhijun's corruption cases related micro-blog discourse, the hidden in the micro-blog discourse under the network the critical ideology of corrupt officials revealed, further embodiment of people's right consciousness is awakened in the imperceptibly, people express their views more independently, to express their own discourse power by micro-blog discourse.

  2. δ-ALA-PDT治疗面部基底细胞癌、Bowen病及日光性角化病的临床研究%The clinical research on treating facial basal cell carcinoma,Bowen's disease and actinic keratosis with δ-Aminolaevulinic acid-photodynamic therapy

    Institute of Scientific and Technical Information of China (English)

    李洁思; 李森真; 李春香

    2009-01-01

    目的 探讨δ-氨基酮戊酸光动力学疗法(δ-ALA -PDT)治疗面部浅表基底细胞癌(BCC)、Bowen病(BD)及日光性角化病(AK)的近期效果.方法 24例患者中,16例皮肤BCC,3例BD病,5例AK,均经病理组织学确诊.局部外用新鲜配制的20%ALA乳膏,封包4 h后用中心波长630 nm的德国Waldmann PDT 1200不连续红光照射,病变部位照射强度为105~168 mW/cm2,剂量为150~200 J/cm2,照射时间20~30 min.结果 经过1次(12例)、2次(3例)和3次(1例)治疗后,BCC患者10例完全缓解,5例部分缓解,1例无反应;BD患者2例完全缓解,1例部分缓解;AK患者3例完全缓解,2例部分缓解.结论 δ-ALA-PDT治疗面部浅表BCC、BD病及AK有效,方法简单,患者耐受性好,无瘢痕形成,在保持患者面部美容方面有优势.

  3. 急性心肌梗塞病人的负性情绪研究%A Comparative Study of Negative Emotion Between Acute Myocardial Infarction and Normal Persons

    Institute of Scientific and Technical Information of China (English)

    程艳春; 邹文华; 巢检化; 何杏桃

    2003-01-01

    Objective: To study etiological relation of negative emotion and acute myocardial infarct ( AMI), Methods: 51 AMI patients and 50 normal persons were investigated with SCL - 90, SAS, SDS, LES, SSRS, Results: Competed normal group with AMI group, AMI patients got significant higher score in anxiety, depression, obsession, interpersonal sensitivity, hostility, phobia, pa-ranoid, somatization and negative life events in a year before AMI as well as had significant lower score in social supports( P < 0.01 ), Conclusion: negative emotion, more negative life events and lacking social supports may be high risk factors of AMI and make patients'' condition worsening.

  4. Long-term recurrence of nonmelanoma skin cancer after topical methylaminolevulinate photodynamic therapy in a dermato-oncology department.

    Science.gov (United States)

    Cabete, Joana; Rafael, Margarida; Cravo, Mariana; Moura, Cecília; Sachse, Fernanda; Pecegueiro, Manuela

    2015-01-01

    Most available studies on the efficacy of topical photodynamic therapy focus on short-to medium-term results. Long-term data are scarce. To evaluate the long-term efficacy of photodynamic therapy with topical methylaminolevulinate to treat Bowen's disease and basal cell carcinoma in the clinical practice setting of a dermato-oncology department. The study included patients diagnosed with Bowen's disease or basal cell carcinoma, and who received photodynamic therapy from 2004 to 2008. Treatment protocol and clinical follow-up were standardized. The primary endpoint was clinically observed recurrence in a previous photodynamic therapy-treated area. Descriptive and survival analyses were performed. A total of 31 Bowen's disease lesions and 44 superficial basal cell carcinoma were treated, with a median follow-up of 43.5 months. Recurrence was observed in 14 Bowen's disease lesions (53.8%) and in 11 superficial basal cell carcinoma (33.3%). Significantly higher estimates for recurrence rates were found in patients with Bowen's disease (p=0.0036) or those aged under 58 years (p=0.039). The risk of recurrence was higher in patients with Bowen's disease than in those with superficial basal cell carcinoma and younger patients. Recurrence should be considered when choosing to treat non-melanoma skin cancer with photodynamic therapy. Younger age and Bowen's disease were independent predictors for long-term recurrence, suggesting the need to establish an extended period of follow-up for this subset of patients.

  5. 76 FR 14827 - Disclosure of Returns and Return Information to Designee of Taxpayer

    Science.gov (United States)

    2011-03-18

    ...: Concerning the proposed regulation, contact Amy Mielke, (202) 622-4570; concerning submissions of comments... principal author of this proposed regulation is Amy Mielke, Office of the Associate Chief Counsel...

  6. 78 FR 26506 - Disclosure of Returns and Return Information to Designee of Taxpayer

    Science.gov (United States)

    2013-05-07

    ... INFORMATION CONTACT: Amy Mielke, (202) 622-4570 (not a toll-free number). SUPPLEMENTARY INFORMATION: Paperwork... the final regulations is Amy Mielke, Office of the Associate Chief Counsel (Procedure...

  7. Short-term prognosis and risk factors of ventricular septal rupture following acute myocardial infarction

    Institute of Scientific and Technical Information of China (English)

    胡小莹

    2013-01-01

    Objective To analyze the short-term prognosis and risk factors of ventricular septal rupture(VSR)following acute myocardial infarction(AMI).Methods A total of 70 consecutive VSR patients following AMI hospitalized in

  8. Short-term prognosis and risk factors of ventricular septal rupture following acute myocardial infarction

    Institute of Scientific and Technical Information of China (English)

    胡小莹

    2013-01-01

    Objective To analyze the short-term prognosis and risk factors of ventricular septal rupture(VSR)following acute myocardial infarction(AMI).Methods A total of 70 consecutive VSR patients following AMI

  9. Aldosterone blockade in post-acute myocardial infarction heart failure

    NARCIS (Netherlands)

    Pitt, Bertram; Ferrari, Roberto; Gheorghiade, Mihai; van Veldhuisen, Dirk J.; Krum, Henry; McMurray, John; Lopez-Sendon, Jose

    2006-01-01

    Development of heart failure (HF) or left ventricular systolic dysfunction (LVSD) significantly increases mortality post acute myocardial infarction (AMI). Aldosterone contributes to the development and progression of HF post AMI, and major guidelines now recommend aldosterone blockade in this setti

  10. Dicty_cDB: FC-BJ12 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available AEQVVKKSASLLAKLASRAKGRVLDSAIESQIG EGNFFARIT*rqgqvgkcdgyileake*nstkedskrrntnk*tyrlfys*kkkkkkkk Translated Ami...PYKQWYETHYGVVVGKKKSAKKDGEAEQVVKKSASLLAKLASRAKGRVLDSAIESQIG EGNFFARIT*rqgqvgkcdgyileake*nstkedskrrntnk*tyrlfy

  11. Prognosis of late versus early ventricular fibrillation in acute myocardial infarction

    DEFF Research Database (Denmark)

    Jensen, G V; Torp-Pedersen, C; Køber, L;

    1990-01-01

    To determine the prognosis of late ventricular fibrillation (VF) after acute myocardial infarction (AMI), the length of the monitoring period after AMI was extended. All patients in this series were continuously monitored in a coronary care unit to ensure observation of all VF within 18 days of AMI...

  12. Design, Construction, and Validation of Artificial MicroRNA Vectors Using Agrobacterium-Mediated Transient Expression System.

    Science.gov (United States)

    Bhagwat, Basdeo; Chi, Ming; Han, Dianwei; Tang, Haifeng; Tang, Guiliang; Xiang, Yu

    2016-01-01

    Artificial microRNA (amiRNA) technology utilizes microRNA (miRNA) biogenesis pathway to produce artificially selected small RNAs using miRNA gene backbone. It provides a feasible strategy for inducing loss of gene function, and has been applied in functional genomics study, improvement of crop quality and plant virus disease resistance. A big challenge in amiRNA applications is the unpredictability of silencing efficacy of the designed amiRNAs and not all constructed amiRNA candidates would be expressed effectively in plant cells. We and others found that high efficiency and specificity in RNA silencing can be achieved by designing amiRNAs with perfect or almost perfect sequence complementarity to their targets. In addition, we recently demonstrated that Agrobacterium-mediated transient expression system can be used to validate amiRNA constructs, which provides a simple, rapid and effective method to select highly expressible amiRNA candidates for stable genetic transformation. Here, we describe the methods for design of amiRNA candidates with perfect or almost perfect base-pairing to the target gene or gene groups, incorporation of amiRNA candidates in miR168a gene backbone by one step inverse PCR amplification, construction of plant amiRNA expression vectors, and assay of transient expression of amiRNAs in Nicotiana benthamiana through agro-infiltration, small RNA extraction, and amiRNA Northern blot.

  13. Effects of calcium ion concentration on starch hydrolysis of barley α-amylase isozymes

    DEFF Research Database (Denmark)

    Yuk, Jeong-Bin; Choi, Seung-Ho; Lee, Tae-Hee

    2008-01-01

    in glucose, maltose, or maltotriose. Against insoluble blue starch, AMY1 showed the highest activity at 0.1-5 mM calcium concentration, whereas 15-20 mM was optimal for AMY2. On the hydrolysis of soluble starch, unexpectedly, there was no significant difference between AMYs with increase of calcium. However...

  14. Mortality and Revascularization following Admission for Acute Myocardial Infarction: Implication for Rural Veterans

    Science.gov (United States)

    Abrams, Thad E.; Vaughan-Sarrazin, Mary; Kaboli, Peter J.

    2010-01-01

    Introduction: Annually, over 3,000 rural veterans are admitted to Veterans Health Administration (VA) hospitals for acute myocardial infarction (AMI), yet no studies of AMI have utilized the VA rural definition. Methods: This retrospective cohort study identified 15,870 patients admitted for AMI to all VA hospitals. Rural residence was identified…

  15. Presenting the networked home: a content analysis of promotion material of Ambient Intelligence applications

    NARCIS (Netherlands)

    Ben Allouch, Soumaya; van Dijk, Johannes A.G.M.; Peters, O.

    2006-01-01

    Ambient Intelligence (AmI) for the home uses information and communication technologies to make users’ everyday life more comfortable. AmI is still in its developmental phase and is headed towards the first stages of diffusion. Characteristics of AmI design can be observed, among others, in the

  16. Thrombolytic therapy preserves vagal activity early after acute myocardial infarction

    DEFF Research Database (Denmark)

    Lind, P; Hintze, U; Møller, M

    2001-01-01

    OBJECTIVE: The purpose of this study was to evaluate the effects of thrombolytic therapy on vagal tone after acute myocardial infarction (AMI). DESIGN: Holter monitoring for 24 h was performed at hospital discharge and 6 weeks after AMI in 74 consecutive male survivors of a first AMI, who fulfill...

  17. The gender specific frequency of risk factor and CHD diagnoses prior to incident MI: a community study.

    Science.gov (United States)

    Yawn, Barbara P; Wollan, Peter C; Yawn, Roy A; Jacobsen, Steven J; Roger, Veronique

    2007-04-04

    CHD is a chronic disease often present years prior to incident AMI. Earlier recognition of CHD may be associated with higher levels of recognition and treatment of CHD risk factors that may delay incident AMI. To assess timing of CHD and CHD risk factor diagnoses prior to incident AMI. This is a 10-year population based medical record review study that included all medical care providers in Olmsted County, Minnesota for all women and a sample of men residing in Olmsted County, MN with confirmed incident AMI between 1995 and 2000. All medical care for the 10 years prior to incident AMI was reviewed for 150 women and 148 men (38% sample) in Olmsted County, MN. On average, women were older than men at the time of incident AMI (74.7 versus 65.9 years, p < 0.0001). 30.4% of the men and 52.0% of the women received diagnoses of CHD prior to incident AMI (p = 0.0002). Unrecognized and untreated CHD risk factors were present in both men (45% of men 5 years prior to AMI) and women (22% of women 5 years prior to first AMI), more common in men and those without a diagnosis of CHD prior to incident AMI (p < 0.0001). A CHD diagnosis prior to incident AMI is associated with higher rates of recognition and treatment of CHD risk factors suggesting that diagnosing CHD prior to AMI enhances opportunities to lower the risk of future CHD events.

  18. Quality of Care for Myocardial Infarction in Rural and Urban Hospitals

    Science.gov (United States)

    Baldwin, Laura-Mae; Chan, Leighton; Andrilla, C. Holly A.; Huff, Edwin D.; Hart, L. Gary

    2010-01-01

    Background: In the mid-1990s, significant gaps existed in the quality of acute myocardial infarction (AMI) care between rural and urban hospitals. Since then, overall AMI care quality has improved. This study uses more recent data to determine whether rural-urban AMI quality gaps have persisted. Methods: Using inpatient records data for 34,776…

  19. Quality of Care for Myocardial Infarction in Rural and Urban Hospitals

    Science.gov (United States)

    Baldwin, Laura-Mae; Chan, Leighton; Andrilla, C. Holly A.; Huff, Edwin D.; Hart, L. Gary

    2010-01-01

    Background: In the mid-1990s, significant gaps existed in the quality of acute myocardial infarction (AMI) care between rural and urban hospitals. Since then, overall AMI care quality has improved. This study uses more recent data to determine whether rural-urban AMI quality gaps have persisted. Methods: Using inpatient records data for 34,776…

  20. High-sensitivity troponin assays for the early rule-out or diagnosis of acute myocardial infarction in people eith acute chest pain: a systematic review and cost-effectiveness analysis

    NARCIS (Netherlands)

    M. Westwood (Marie); T. van Asselt (Thea); B. Ramaekers (Bram); P. Whiting (Penny); P. Tokala (Praveen); M.A. Joore (Manuela); N. Armstrong (Nigel); J. Ross (Janine); J.L. Severens (Hans); J. Kleijnen (Jos)

    2015-01-01

    textabstractBackground: Early diagnosis of acute myocardial infarction (AMI) can ensure quick and effective treatment but only 20% of adults with emergency admissions for chest pain have an AMI. High-sensitivity cardiac troponin (hs-cTn) assays may allow rapid rule-out of AMI and avoidance of unnece

  1. High-sensitivity troponin assays for the early rule-out or diagnosis of acute myocardial infarction in people with acute chest pain : a systematic review and cost-effectiveness analysis

    NARCIS (Netherlands)

    Westwood, Marie; van Asselt, Thea; Ramaekers, Bram; Whiting, Penny; Thokala, Praveen; Joore, Manuela; Armstrong, Nigel; Ross, Janine; Severens, Johan; Kleijnen, Jos

    2015-01-01

    BACKGROUND: Early diagnosis of acute myocardial infarction (AMI) can ensure quick and effective treatment but only 20% of adults with emergency admissions for chest pain have an AMI. High-sensitivity cardiac troponin (hs-cTn) assays may allow rapid rule-out of AMI and avoidance of unnecessary hospit

  2. 77 FR 65125 - Approval and Promulgation of Implementation Plans; Georgia 110(a)(1) and (2) Infrastructure...

    Science.gov (United States)

    2012-10-25

    ... in permit actions--Plant Bowen's title V Permit and Plant Washington's PSD permit--to support its... FR Maintenance Plan. encompassing a 53432. portion of Monroe County. 26. Murray County 8-hour...

  3. Postpartum Support International

    Science.gov (United States)

    ... Dads for World Maternal Mental Health Day Overview Tips for Postpartum Dads and Partners Beyond the Blues: Partners Resources for Fathers Interview with Wade Bowen Coping with Suicide & Loss Perinatal ...

  4. ON HF (TLD -100) PHOSPHORS

    African Journals Online (AJOL)

    2005-08-19

    Aug 19, 2005 ... Department of Physics and Solar Energ/, Bowen University, Two, Nigeria ... annealing at higher temperatures for longer length of time appears to improve the sensitivity of the ... reported that it was sublinear at low dose;.

  5. A sequential mixed methods research approach to investigating HIV ...

    African Journals Online (AJOL)

    2016-09-03

    Sep 3, 2016 ... show that corporate knowledge about HIV/AIDS is inconsistent .... Gilbert, Cattell, Edwards & Bowen • A sequential mixed methods ... 29 substantial ..... formal sector. However ..... Construction Engineering and Management.

  6. Measurements and modelling of evapotransiration to assess agricultural water productivity in basins with changing land use patterns : a case study in the São Francisco River basin, Brazil

    NARCIS (Netherlands)

    Castro Teixeira, de A.H.

    2008-01-01

    Key words: Vineyards, mango, energy balance, evapotranspiration, water productivity, Bowen ratio, eddy correlation, water balance, natural vegetation, latent heat flux, sensible heat flux, biomass, water productivity, remote sensing, water management. . The São Francisco River basin in Brazil is

  7. 77 FR 75622 - Notice of Intent to Grant an Exclusive License of the United States; Patent No. 6,569,807

    Science.gov (United States)

    2012-12-21

    ..., Mycoleptodiscus terrestris, to produce survival propagules termed microsclerotia in fermentation broth culture... aquatic plant control. Brenda S. Bowen, Army Federal Register Liaison Officer. BILLING CODE 3720-58-P...

  8. Risk of stroke after acute myocardial infarction among Chinese

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Following an acute myocardial infarction (AMI), patients have an increased risk of stroke. Estimates of risk are mainly derived from AMI treatment trials or secondary prevention studies. The reported incidence of stroke in Caucasians in the early phase after AMI ranged from 0.5% to 2.5%.1-3 Similar assessment of risk in the Chinese population is lacking. As thrombolytic therapy becomes standard treatment for AMI, there is concern that there may be an increase in haemorrhagic stroke complicating AMI treatment, especially since haemorrhagic stroke is more common in Asian populations.

  9. Temporal decline in the prognostic impact of a recurrent acute myocardial infarction 1985 to 2002

    DEFF Research Database (Denmark)

    Buch, P.; Rasmussen, S.; Gislason, Gunnar Hilmar

    2007-01-01

    OBJECTIVE: To investigate trends in case-fatality and prognostic impact from recurrent acute myocardial infarction (re-AMI) during 1985-2002. DESIGN: Retrospective cohort study using nationwide administrative data from Denmark. Settings: National registries on hospital admissions and causes...... of death were linked to identify patients with first AMI, re-AMI and subsequent prognosis. PATIENTS: Patients > or =30 years old with a discharge diagnosis of AMI during 1985-2002 were tracked for first hospital admission for re-AMI 1 year after discharge. MAIN OUTCOME MEASURES: One-year case...

  10. Enhancing recruitment of African-American families into genetic research: lessons learned from Project SuGar

    OpenAIRE

    2010-01-01

    Despite some recruitment success in biomedical research among minorities, participation by African-American families into research, specifically genetic research, is lower than Caucasian families (Bowen and Penchaszadeh Community Genet 11:189–190, 2008). Such low participation rates by African-Americans prevent the exploration of specific ethnic differences in patterns of diseases and diminish the identification of specific disease risks among ethnic groups (Bowen and Penchaszadeh Community G...

  11. In Silico Investigation of Intracranial Blast Mitigation with Relevance to Military Traumatic Brain Injury

    Science.gov (United States)

    2010-09-01

    field overpressure was selected to be above the threshold for unarmored blast lung injury given by the Bowen curves, which estimate the tolerance to a...Explosive blast neurotrauma. J Neurotraum 28:815–825. 11. Murray C, et al. (2005) Spectrum of care provided at an Echelon II medical unit during...Nashville, TN), Vol C2.00001. 23. Bowen I, Fletcher E, Richmond D, Hirsch F, White C (1968) Biophysical mechanisms and scaling procedures applicable in

  12. Energy Partition From Various Climate Conditions And Land Use Types

    Science.gov (United States)

    Cheng, Chi-Han; Hsu2, Pang-Chi

    2015-04-01

    Investigating how energy partitions and what factors control energy exchange is critical for better understanding the hydrological cycle, boundary layer dynamics, and land -atmosphere coupling. Climate and land use conditions are the two main factors to control energy partitation. However, previous studies discussed energy partition and factors that controlled Bowen ratio (i.e., ratio of sensible heat flux to latent heat flux) in limited land use types and climate conditions. To provide a more comprehensive analysis over various climate and vegetation types, in this study, we studied eleven different land use types in the eight different climate zones within the United State. The results found out that the Mediterranean climate zone with dry summer season, dry arid (desert) climate zone, and the higher latitude area with severe winter would had higher Bowen ratio, lower precipitation and net radiation. In contrast, the humid climate zones had the lower Bowen ratio, higher net radiation and precipitation. Moreover, the higher Bowen ratio usually happened in the winter or early spring seasons. Regarding land conditions, it is found that soil moistures are the key factor to control Bowen ratio in the drier climate areas. Hence, the grassland and closed shrublands sites have higher Bowen ratio than deciduous broadleaf forests and evergreen needle-leaf forests sites' because of shallower root systems that lack access to the full storage of water in the vadose zone. However, in the humid areas, land use factors, such as stomatal resistance and leaf area, would play an important role in changing latent heat and sensible heat. Based on the tight relationships between Bowen ratio and conditions of climate and land use, we suggest that Bowen ratio could be a useful tool for understanding the potential feedbacks of changes in climate and land use to energy partition and exchange.

  13. Uncommon Presentation Of Bowen′s Disease

    Directory of Open Access Journals (Sweden)

    Dawn Goutam

    1995-01-01

    Full Text Available Bowen’s disease is desired as persistent, progressive, non- elevated, red scarry or crusted plaque, which is due to an intraepidermal carcinoma and is potentially malignant. Sunlight is considered as an important aetiological factor. In the past; arsenic exposure was also said to be important 1. The curaneous lesion of Bowen’s disease can sometimes be hyperkeratotic or fissured 2. Morphology can vary depending on site of involvement.

  14. Le Bret, Cuigy, Casteljaloux, Bignon, Royer de Prade et Regnault des Boisclairs : du nouveau sur quelques bons amis de Cyrano et sur l’édition posthume des états et empires de la lune (1657

    Directory of Open Access Journals (Sweden)

    Madeleine Alcover

    2009-02-01

    Full Text Available This article deals mainly with Henry Le Bret, Cyrano’s friend and editor. Only Le Bret’s Parisian years are concerned here, the ones which preceeded his clerical career in Montauban.Till now very little was known of Le Bret’s Parisian period and nothing at all of his career as a « avocat au Conseil Privé du Roi ». Long investigations in Archives Nationales (Paris, CARAN, mainly in notarial deeds (Minutier Central and in Conseil Privé’s archives (series V6, as well as in Archives départementales de Tarn-et-Garonne (Montauban, allowed me to revive many of his friends and clients : in the second category can be found Bishop of Albi, Gaspard de Daillon du Lude, related to the Roquelaures, and to Cyrano through the wealthy Feydeau family ; in the first category appear many people named in Le Bret’s posthumous preface of Cyrano’s Etats et Empires de la Lune (1657, like the Cuigys, the Durets, Captain Carbon de Casteljaloux, the engraver Bignon and the dramatist and historian Royer de Prade. They were all living in a delimited area of the « Marais » (Right Bank : rues de la Verrerie, des Billettes, Sainte-Croix de la Bretonnerie, Simon Lefranc and Sainte-Avoye ; even Cyrano’s protectors were there, Regnault des Boisclairs at rue de la Verrerie, and Duke of Arpajon, whose residence partly burnt in January 1655, at Vieille rue du Temple. A precious notarial deed reveals that Le Bret was a cleric before Cyrano died, situation which should bring a new light on the making of the posthumous edition, published with numerous cuts (« lacunes » and variants ; another notarized document concerns the donation of Clamard « seigneurie » to Cuigy junior in 1656, donation which not only explains a variant of the posthumous edition but also provides an irrefutable evidence that Cyrano’s novel was altered after his death.Among the addenda completing this article are the autograph last will of Casteljaloux, written in 1642 in Clamard where he died in 1654, the donation of Clamard to Cuigy junior (1656 and a substantial repayment to Le Bret by Royer de Prade (1657 just before the former went to Montauban.

  15. The Characteristics of Cellulase and Amylase from B.amy lolique f aciens FAJT-8754 and Optimization of Fermentation Conditions%解淀粉芽胞杆菌FJAT-8754产纤维素酶和淀粉酶特性及发酵条件优化

    Institute of Scientific and Technical Information of China (English)

    王凯; 蓝江林; 刘波; 刘程程; 李安琪

    2014-01-01

    采用淀粉平板和羧甲基纤维素钠(CMC-Na)平板从选取的140株芽胞杆菌中初筛出8株具有产纤维素酶和淀粉酶复合酶芽胞杆菌,经酶活力测定解淀粉芽胞杆菌FJAT-8754(Bacillus amyloliquef aciens)具有较高的淀粉酶、纤维素酶活力。通过研究解淀粉芽胞杆菌FJAT-8754的生长、产酶曲线以及酶学特性,确定在发酵28 h后菌体生长进入稳定期,培养44 h时发酵液中活菌数达到最大为4.41×109 cf u · mL -1,在36 h时纤维素酶、淀粉酶均达到酶活最高峰,酶活分别为135.8、1543.3 U · mL -1;纤维素酶反应最适p H值为5.5、最适温度为50℃,Vmax为5.14×10-3 mg · mL -1· min-1、 Km值为7.71×10-1 mg · mL -1;淀粉酶反应最适pH值为5.5、最适温度为55℃,Vmax为3.35×10-2 mg · mL -1· min-1、 Km值为6.03×10-3 mg · mL -1。采用3因素7水平,即U 7(73)均匀设计法优化解淀粉芽胞杆菌产酶条件,确定产纤维素酶、淀粉酶的最优条件均为:初始pH值6.2、培养温度37.5℃、转速180 r · min-1,优化后解淀粉芽胞杆菌 FJAT-8754纤维素酶活力为202.9 U·mL -1、淀粉酶活力为2392.9U·mL -1。%Eight Bacillus strains which produce cellulase and amylase were screened from 140 standard Bacillus strains by using starch medium and carboxymethylcellulose sodium (CMC-Na) plate screening method .FJAT-8754 had the highest cellulase and amylase producing activities and the biological characterizes (e .g .growth curves , dynamic changes of enzyme activity and enzymatic properties ) were tested .Our results suggested that the stationary phase of FJAT-8754 was at 28 h ,the colony count was 4.41 × 109 cfu · mL -1 at 44 h and the activity of cellulase and amylase peaked at 36 h simultaneously .Meanwhile ,the optimum reaction conditions for cellulase were at pH 5.5 ,55℃ ,Vmax was 5.14 × 10-3 mg · mL -1 · min-1 and Km was 7.71 × 10-1 mg · mL -1 ;the optimal reaction conditions of amylase were at pH 5.5 ,60℃ ,Vmax was 3.35 × 10-2 mg · mL -1 · min-1 and Km was 6.03 × 10-3 mg · mL -1 .Furthermore ,uniform design assays showed that the optimal submerged culture conditions for cellulase and amylase was at pH 6.2 ,fermentation temperature was at 37.5℃ ,shaking speed was 180 r · min-1 ,and the activity of cellulase and amylase could reach 202.9 , 2 392.9 U · mL -1 , respectively .

  16. Fiches pratiques: Si on jouait a la famille Dubois...; Pic et pic...et phonetique; Les rendez-vous des souvenirs; A l'ami (Practical Ideas: Let's Play House; Tick and Tick...and Phonetic; Rendezvous with Memories; To My Friend).

    Science.gov (United States)

    Bravo, Maria Antonia Lavandera; And Others

    1991-01-01

    Four activities for French language classroom use are presented, including a simulation of the relationships and communication within a family; pronunciation instruction through phonetic transcription; cultural awareness through students' analysis of their own and their parents' specific memories; and analysis and comparison of a literary text and…

  17. 急性心肌梗死后急性期室壁瘤形成患者血浆脑钠素的动态变化和意义%The Clinical Significance of Dynamic Change of Plasma BNP Concentration in Patients with AVA Formation after AMI

    Institute of Scientific and Technical Information of China (English)

    陈欣华; 李燕; 孟文格

    2008-01-01

    目的:探讨急性心肌梗死(AMl)后急性期室壁瘤(AVA)形成患者皿浆脑钠素(BNP)的动态变化和意义.方法:测定AMI患者发病后6h、12h、18h、1d、2d、3d、5d、24w的血浆BNP浓度.结果:有AVA形成组患者血浆BNP浓度存所测时间点高于无AVA形成组患者,BNP峰值浓度高于无AVA形成组患者,为(12.30±2.24)ng/ml、vs(9.92 ±2.54)ng/ml,P<0.01;峰值时间早于无AVA形成组患者,峰值时间提前2.07h,有统计学差异[(20.48±3.77)h vs(22,55±3.68)h,P<0.01];结论:AMI后AVA形成组患者血浆BNP的峰值浓度明显高于无AVA形成组患者,且其达到峰值时间明显提前.

  18. On-call x-rays made easy AN Au-Yong On-call x-rays made easy , Amy Au-Yong and Nigel Broderick Churchill Livingstone Elsevier £21.99 304pp 9780702034459 0702034452 [Formula: see text].

    Science.gov (United States)

    2011-02-10

    DesigneD for clinicians involved in the management of acutely ill patients, this book enables them to recognise quickly the appearance of life-threatening conditions. It also concentrates on the interpretation of plain chest and abdominal images.

  19. 无创正压通气治疗对肌萎缩侧索硬化患者预后影响的研究%Effect to prognosis by early or late use of noninvasive positive pressure ventilation in patients with amy­ otrophic lateral sclerosis

    Institute of Scientific and Technical Information of China (English)

    邓畔; 樊东升

    2015-01-01

    目的:研究肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)患者使用无创正压通气(noninvasive positive pressure ventilation,NIPPV)治疗对其生存时间的影响。方法回顾性分析2003~2012年本院神经内科ALS数据库资料,根据国际E1 Escorial诊断标准入选并随访全部患者,采用统一设计的病例报告表(CRF)记录患者相关临床数据,将用力肺活量(FVC)≥50%或临床尚无呼吸困难症状时开始使用NIPPV治疗的患者纳入早期使用组、FVC<50%或临床已有呼吸困难症状时开始使用NIPPV治疗的患者纳入晚期使用组。每3个月对患者进行电话随访并记录变化信息。结果1697例ALS患者中,208例使用了NIPPV治疗,其中,有完整FVC或呼吸困难症状资料者147例,早期使用组47例,晚期使用组100例,两组患者在诊断分型、起病部位、确诊延迟时间、开始使用NIPPV治疗时的球部症状、体质指数(BMI)等方面存在显著差异;将两组按1︰1进行巢式配对,并对相关数据进行单因素及多因素分析,结果显示,以FVC 50%和呼吸症状作为使用NIPPV治疗的指标对生存时间无显著影响。结论依据FVC 50%和呼吸症状作为使用NIPPV治疗的指标并未明显延长ALS患者的生存时间。%ObjectiveTo observe the effect to survival time of amyotrophic lateral sclerosis (ALS) patients by early or late onset use of noninvasive positive pressure ventilation (NIPPV).MethodRetrospectively analyzed the patients in the database of ALS patients admitted from outpatient in neurology department of Peking University Third Hospital from 2003 to 2012. Chose the patients who were diagnosed as ALS according to the Escorial Criteria and whose diagnosing grade was definite, probable or possible, another criteria was that their diagnosis as ALS didn’t change during our follow-up, used the same designed recording book to record their clinic materials, and followed up them by phone every 3 months and also recorded the related clinic materials.ResultIn the database of 1697 ALS patients in our department from 2003 to 2012, 208 patients used NIPPV. We deifned the patients who began to use NIPPV when their FVC≥50% or they didn’t have respiratory symptom as early-onset users, and those who began to use NIPPV when their FVC<50% or they had respiratory symptom as late-onset users. Then we analyzed the 147 ALS patients (47 early-onset users, 100 late-onset users) who had complete data and use NIPPV, and we found there was signiifcant difference between early-onset and late-onset users in these factors, namely, subtype of diagnosis, subtype of diagnosis, onset site, delay time of diagnosis, exist bulbar symptom and BMI when patients began to use NIPPV. So we matched the 47 early-onset users to 47 late-onset users and divided them into groups with or without bulbar symptom when they began to use NIPPV in order to make sure that every factor was compatible. We analyzed the data above using the single-factor analysis and multiple-factor analysis and foundthat survival time was compatible between early-onset and late-onset users.ConclusionUsing FVC and respiratory symptom as criteria to deifne early-onset and late-onset users, our retrospective nonsynchronous control research suggested that early-onset users of NIPPV didn’t extend their survival time than late-onset users.

  20. Burden and Grace——on Christian Color in Amy Tan's Novels and the Literary Value%重负与神恩——论谭恩美小说中的基督教色彩及其文学价值

    Institute of Scientific and Technical Information of China (English)

    王文胜

    2014-01-01

    谭恩美是美国当代著名的华裔女作家,她的小说叙事与《圣经》文本有密切的关联,这是被研究者所忽略的.一方面她吸纳了基督教对人性的理解,突破了东西方的界限来探究人性深处的罪恶和良善,另一方面她对《圣经》资源的利用也表明中国故事同样可以借助于《圣经》资源来完成叙事.这是值得中国当代作家借鉴的.

  1. 国内常用三分法画钟测验在阿尔茨海默病和血管性痴呆中的鉴别作用%Function of Three-point Scoring System for the Clock Drawing Test in Differentiating between Alzbeimer's Disease ami Vascular dementia in China

    Institute of Scientific and Technical Information of China (English)

    郎琪; 杨雪; 冯虹; 陈宁; 何俐

    2011-01-01

    Objective To investigate the differential function of the three-point scoring system for the clock drawing test (CDT) between Alzheimer's disease (AD) and vascular dementia (VD).Methods We analyzed the clinical data of 150 patients with cognitive impairment treated in the neurology and inpatient departments of our hospital from September 2009 to July 2010.Medical history of the subjects were collected.Through the assessment by neurological and psychological rating scale, we picked out 57 patients with AD and 43 with VD and tested them with CDT.The difference of CDT results between the two groups, and the correlation of CDT with Chinese version of the mini-mental state examination (MMSE) and clinical dementia rating scale (CDR) were analyzed.Results There was no statistical difference of CDT results between AD and VD patients (P>0.005).CDT had a correlations with MMSE and CDR, the Spearman correlation coefficient being 0.573 and -0.542 respectively (P<0.001).Conclusion The three-point scoring system for the dock drawing test cannot differentiate exactly between Alzheimer Disease and Vascular Dementia, but it can make a gross judgment of the degree of AD and VD.%目的 探讨3分法画钟测验(clock drawing test,CDT)对阿尔茨海默病患者(Alzheimer disease,AD)与血管性痴呆患者(vascular dementia,VD)的鉴别作用.方法 收集四川大学华西医院神经内科门诊及住院部2009年9月-2010年6月就诊的认知功能障碍患者150例,进行病史采集及神经心理测试量表,筛选出AD患者57例及VD 患者43例,共计纳入100例.在两者间进行CDT,分析两者间CDT有无差别、CDT与中文版简易智能量表(Chinese version of the mini-mental state examination,MMSE)及临床痴呆评定量表(clinical dementia rating scale,CDR)的相关性.结果 AD患者及VD患者间CDT差异无统计学意义(P>0.05);CDT与MMSE及CDR有相关性,Spearman 相关系数分别为0.573和-0.542(P<0.001).结论 3分法画钟测验无法准确区分AD和VD,但对粗略判断AD 及VD程度可能有一定效果.

  2. The Study of Protection and Mechanism Effect of CJY Flavanoid on the Beta-amy-loid Peptide 25-35-induced Injury in PC12%黄酮类化合物对 Aβ25-35介导的 PC12细胞损伤的保护及机制研究

    Institute of Scientific and Technical Information of China (English)

    樊茹

    2016-01-01

    目的:探讨黄酮类化合物(CJY)对β-淀粉样蛋白25-35(Aβ25-35)介导的 PC12细胞(大鼠嗜铬细胞瘤细胞)氧化损伤的保护作用及其可能机制。方法:对 PC12细胞采用不同浓度的 Aβ25-35进行损伤,MTT 法测定PC12细胞的损伤率和存活率;采用 SOD 试剂盒检测 Aβ25-35对 PC12细胞的氧化损伤;使用 DCFH-DA 结合活细胞高内涵成像系统检测细胞内 ROS 的水平。结果:经终浓度为10μM的 Aβ25-35对 PC12细胞损伤后,可降低细胞的存活率,而浓度为5μM,10μM,50μM的 CJY 呈浓度依赖性地提高 PC12细胞的存活率,并明显改善细胞形态。Aβ25-35可触发细胞内的氧化应激反应,造成细胞氧化损伤,提高细胞内 ROS 水平,降低细胞内 SOD 的活性;CJY 则降低细胞内 ROS 水平,升高 SOD 的活性,具有明显的抗氧化损伤作用。结论:通过离体实验证明黄酮类化合物CJY 对 Aβ25-35诱导的 PC12细胞损伤有保护作用,为进一步研究黄酮类化合物在阿尔茨海默病中的应用提供实验依据。%Objective:To explore the the protective effects and the potential mechanism of CJY flavanoids on inju-ries induced by the beta-amyloid peptide25-35( Aβ25-35 )in rat pheochromocytoma cells( PC12 cells). Methods:The Aβ25-35 with different concentrations were used to cause injuries in PC12 cells by the same way. The damage and survival rate of PC12 cells were detected by MTT as well as Oxidative damage by SOD and the content level of ROS in cells by DCFH-DA combined with living cells high content imaging system. Results:The injuries induced by the Aβ25-35 with the concentration of 10 μM resulted in the significant decrease of the survival rate of PC12 cells. CJY flavonoids(concentra-tions:5 μM,10 μM,50 μM)could markedly improve damage cells form and the survival rate of PC12 cells,which was dose-dependent. The oxidative stress in cells could be triggered by the Aβ25-35 ,which increased the intracellular ROS lev-el and significantly decreased the activity of SOD,resulting in oxidative damage in cells,while flavonoids caused the ob-vious protective action against oxidative damage. Conclusions:The experiment in vitro has proved the the protective effects of flavanoids on the Aβ25-35-induced injuries in PC12 cells,which can provide with experimental basis for fla-vanoids being used as a remedy for AD.

  3. No covariation between the geomagnetic activity and the incidence of acute myocardial infarction in the polar area of northern Sweden

    Science.gov (United States)

    Messner, T.; Häggström, I.; Sandahl, I.; Lundberg, V.

    2002-05-01

    This study was undertaken to investigate whether there was any relation between the aurora borealis (measured as the geomagnetic activity) and the number of acute myocardial infarctions (AMI) in the northern, partly polar, area of Sweden. The AMI cases were collected from The Northern Sweden MONICA (multinational MONItoring of trends and determinants of CArdiovascular disease) AMI registry between 1985 and 1998, inclusive, and the information on the geomagnetic activity from continuous measurements at the Swedish Institute of Space Physics, Kiruna. In the analyses, both the relation between the individual AMI case and ambient geomagnetic activity, and the relation between the mean daily K index and the daily number of AMI cases were tested. We found no statistically significant relation between the number of fatal or non-fatal AMI cases, the number of sudden deaths or the number of patients with chest pain without myocardial damage, and geomagnetic activity. Our data do not support a relation between the geomagnetic activity and AMI.

  4. Effects of calcium ion concentration on starch hydrolysis of barley alpha-amylase isozymes.

    Science.gov (United States)

    Yuk, Jeong-Bin; Choi, Seung-Ho; Lee, Tae-Hee; Jang, Myoung-Uoon; Park, Jung-Mi; Yi, Ah-Rum; Svensson, Birte; Kim, Tae-Jip

    2008-04-01

    Barley alpha-amylase genes, amy1 and amy2, were separately cloned into the expression vector of pPICZalphaA and recombinant Pichia strains were established by homologous recombination. Both AMYs from Pichia shared almost identical hydrolysis patterns on short maltooligosaccharides to result in glucose, maltose, or maltotriose. Against insoluble blue starch, AMY1 showed the highest activity at 0.1-5 mM calcium concentration, whereas 15-20 mM was optimal for AMY2. On the hydrolysis of soluble starch, unexpectedly, there was no significant difference between AMYs with increase of calcium. However, the relative activity on various starch substrates was significantly different between AMYs, which supports that the isozymes are clearly distinguished from each other on the basis of their unique preferences for substrates.

  5. Interpretation of positive troponin results among patients with and without myocardial infarction

    Science.gov (United States)

    Tecson, Kristen M.; Arnold, William; Barrett, Tyler; Birkhahn, Robert; Daniels, Lori B.; DeFilippi, Christopher; Headden, Gary; Peacock, W. Frank; Reed, Michael; Singer, Adam J.; Schussler, Jeffrey M.; Smith, Stephen; Than, Martin P.

    2017-01-01

    Measuring cardiac troponins is integral to diagnosing acute myocardial infarction (AMI); however, troponins may be elevated without AMI, and the use of multiple different assays confounds comparisons. We considered characteristics and serial troponin values in emergency department chest pain patients with and without AMI to interpret troponin excursions. We compared serial troponin in 124 AMI and non-AMI patients from the observational Performance of Triage Cardiac Markers in the Clinical Setting (PEARL) study who presented with chest pain and had at least one troponin value exceeding the 99th percentile of normal. Because 8 assays were used during data collection, we employed a method of scaling the troponin value to the corresponding assay's 99th percentile upper reference limit to standardize the results. In 81 AMI patients, 96% had elevated troponin at the first test following initial elevation, compared to 73% of the 43 non-AMI patients (P < 0.001). Scaling troponin to the 99th percentile of normal yielded a median value that was 4.8 [2.2, 14.1] times higher than the 99th percentile cutpoint among AMI patients, compared to 2.3 [1.5, 6.5] times higher among non-AMI patients (P = 0.04). The rise in serial scaled troponin values distinguished the AMI patients. Scaling to the 99th percentile was useful for comparing troponin when different assays were utilized. PMID:28127121

  6. Pre-existing Arterial Micro-Calcification Predicts Primary Unassisted Arteriovenous Fistula Failure in Incident Hemodialysis Patients.

    Science.gov (United States)

    Choi, Su Jin; Yoon, Hye Eun; Kim, Young Soo; Yoon, Sun Ae; Yang, Chul Woo; Kim, Yong-Soo; Park, Sun Cheol; Kim, Young Ok

    2015-01-01

    Vascular access micro-calcification is a risk factor for cardiovascular morbidity and mortality in hemodialysis (HD) patients but its influence on vascular access patency is still undetermined. Our study aimed to determine the impact of arterial micro-calcification (AMiC) on the patency of vascular access in HD patients. One-hundred fourteen HD patients receiving arteriovenous fistula (AVF) operation were included in this study. During the operation, we obtained partial arterial specimen and performed pathological examination by von Kossa stain to identify AMiC. We compared primary unassisted AVF failure within 1 year between positive and negative AMiC groups, and performed Cox regression analysis for evaluating risk factor of AVF failure. The incidence of AMiC was 37.7% and AVF failure occurred in 45 patients (39.5%). The AVF failure rate within 1 year was greater in the positive AMiC group than those in the negative AMiC group (53.5% vs. 31.0%, p = 0.02). Kaplan-Meier analysis showed that the positive AMiC group had a lower AVF patency rate than the negative AMiC group (p = 0.02). The presence of AMiC was an independent risk factor for AVF failure. In conclusion, preexisting AMiC of the vascular access is associated with primary unassisted AVF failure in incident HD patients.

  7. Comprehensive protein-based artificial microRNA screens for effective gene silencing in plants.

    Science.gov (United States)

    Li, Jian-Feng; Chung, Hoo Sun; Niu, Yajie; Bush, Jenifer; McCormack, Matthew; Sheen, Jen

    2013-05-01

    Artificial microRNA (amiRNA) approaches offer a powerful strategy for targeted gene manipulation in any plant species. However, the current unpredictability of amiRNA efficacy has limited broad application of this promising technology. To address this, we developed epitope-tagged protein-based amiRNA (ETPamir) screens, in which target mRNAs encoding epitope-tagged proteins were constitutively or inducibly coexpressed in protoplasts with amiRNA candidates targeting single or multiple genes. This design allowed parallel quantification of target proteins and mRNAs to define amiRNA efficacy and mechanism of action, circumventing unpredictable amiRNA expression/processing and antibody unavailability. Systematic evaluation of 63 amiRNAs in 79 ETPamir screens for 16 target genes revealed a simple, effective solution for selecting optimal amiRNAs from hundreds of computational predictions, reaching ∼100% gene silencing in plant cells and null phenotypes in transgenic plants. Optimal amiRNAs predominantly mediated highly specific translational repression at 5' coding regions with limited mRNA decay or cleavage. Our screens were easily applied to diverse plant species, including Arabidopsis thaliana, tobacco (Nicotiana benthamiana), tomato (Solanum lycopersicum), sunflower (Helianthus annuus), Catharanthus roseus, maize (Zea mays) and rice (Oryza sativa), and effectively validated predicted natural miRNA targets. These screens could improve plant research and crop engineering by making amiRNA a more predictable and manageable genetic and functional genomic technology.

  8. Value of multislice computed tomography in the diagnosis of acute mesenteric ischemia

    Energy Technology Data Exchange (ETDEWEB)

    Yikilmaz, Ali, E-mail: dryikilmaz@yahoo.com [Erciyes University, School of Medicine, Gevher Nesibe Hospital, Department of Radiology, Talas Yolu, 38038 Melikgazi, Kayseri (Turkey); Karahan, Okkes Ibrahim; Senol, Serkan; Tuna, Ibrahim Sacit [Erciyes University, School of Medicine, Gevher Nesibe Hospital, Department of Radiology, Talas Yolu, 38038 Melikgazi, Kayseri (Turkey); Akyildiz, Hizir Yakup [Erciyes University, School of Medicine, Gevher Nesibe Hospital, Department of General Surgery, Talas Yolu, 38038 Melikgazi, Kayseri (Turkey)

    2011-11-15

    Objective: To define the value of multislice computed tomography (CT) in the diagnosis of acute mesenteric ischemia (AMI). Materials and methods: Two hundred patients (age range: 20-92 years) who were referred to the emergency CT department with a clinical suspicion of AMI were prospectively included in the study. CT examinations were performed with a multislice (16) CT scanner and the protocol included pre-contrast, arterial and venous phase acquisitions. Images were evaluated by using multiplanar reconstruction, maximum intensity projection and volume-rendering techniques at the CT workstation. Results: Ninety-four patients (47%) underwent surgery for AMI or for other causes of acute abdominal pain. One hundred-six patients (53%) were followed conservatively according to clinical, radiologic and laboratory findings. Of the 94 patients who underwent surgery, 49 (25%) were found to have AMI. All of these 49 patients with a proven AMI diagnosis were diagnosed with CT. In the other 45 patients who underwent surgery, CT findings were negative for AMI. None of the patients, who were followed conservatively, were eventually diagnosed as having AMI except 1 patient. This patient was unfit for surgery although his clinical and radiologic findings were consistent with AMI and died in 3 days. The sensitivity and specificity values of CT for the detection of AMI were calculated to be 100% for each. Conclusions: Multislice CT is an effective imaging technique for the diagnosis of AMI with excellent sensitivity and specificity values.

  9. Structural inversion of the Tamworth Belt: Insights into the development of orogenic curvature in the southern New England Orogen, Australia

    Science.gov (United States)

    Phillips, G.; Robinson, J.; Glen, R.; Roberts, J.

    2016-05-01

    The middle to late Permian Hunter Bowen Event is credited with the development of orogenic curvature in the southern New England Orogen, yet contention surrounds the structural dynamics responsible for the development of this curvature. Debate is largely centred on the roles of orogen parallel strike-slip and orogen normal extension and contraction to explain the development of curvature. To evaluate the dynamic history of the Hunter Bowen Event, we present new kinematic reconstructions of the Tamworth Belt. The Tamworth Belt formed as a Carboniferous forearc basin and was subsequently inverted during the Hunter Bowen Event. Kinematic reconstructions of the Tamworth Belt are based on new maps and cross-sections built from a synthesis of best-available mapping, chronostratigraphic data and new interpretations of depth-converted seismic data. The following conclusions are made from our study: (i) the Hunter Bowen Event was dominantly driven by margin normal contraction (east-west shortening; present-day coordinates), and; (ii) variations in structural style along the strike of the Tamworth Belt can be explained by orthogonal vs. oblique inversion, which reflects the angular relationship between the principal shortening vector and continental-arc margin. Given these conclusions, we suggest that curvature around the controversial Manning Bend was influenced by the presence of primary curvature in the continental margin, and that the Hastings Block was translated along a sinistral strike-slip fault system that formed along this oblique (with respect to the regional east-west extension and convergence direction) part of the margin. Given the available temporal data, the translation of the Hastings Block took place in the Early Permian (Asselian) and therefore preceded the Hunter Bowen Event. Accordingly, we suggest that the Hunter Bowen Event was dominantly associated with enhancing curvature that was either primary in origin, or associated with fault block translation

  10. Effects of Shenqi Fuzheng Injection(参芪扶正注射液)on Changes of Matrix Metalloproteinases in Patients with Acute Myocardial Infarction

    Institute of Scientific and Technical Information of China (English)

    郝玉明

    2004-01-01

    Objective: To investigate the effects of Shenqi Fuzheng injection (参芪扶正注射液, SQFZI)on ventricular remodeling (VR) after acute myocardial infarction (AMI). Methods: Sixty patients with AMI were randomly divided into two groups and received conventional therapy and conventional therapy plus SQFZI separately. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-9 (TIMP-9) in plasma was measured on the 1st and 14th days after AMI. Results: MMP-9 and MMP-9/TIMP-9 were increased after AMI, after 2-week treatment, the level of MMP-9 and MMP-9/TIMP-9 decreased more significantly in SQFZI group than that in the conventional group (P<0.05). Conclusion: Early treatment with SQFZI after AMI could reduce the level of MMPs and the production of collagen. It may be useful for the prevention of VR and heart failure after AMI.

  11. Effects of Shenqi Fuzheng Injection (参芪扶正注射液) on Changes of Matrix Metalloproteinases in Patients with Acute Myocardial Infarction

    Institute of Scientific and Technical Information of China (English)

    郝玉明

    2004-01-01

    Objective: To investigate the effects of Shenqi Fuzheng injection (参芪扶正注射液, SQFZI) on ventricular remodeling (VR) after acute myocardial infarction (AMI). Methods: Sixty patients with AMI were randomly divided into two groups and received conventional therapy and conventional therapy plus SQF-Zl separately. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-9 (TIMP-9) in plasma was measured on the 1st and 14th days after AMI. Results: MMP-9 and MMP-9/TIMP-9 were increased after AMI, after 2-week treatment, the level of MMP-9 and MMP-9/TIMP-9 decreased more significantly in SQFZl group than that in the conventional group (P<0.05). Conclusion: Early treatment with SQFZl after AMI could reduce the level of MMPs and the production of collagen. It may be useful for the prevention of VR and heart failure after AMI.

  12. Predischarge maximal exercise test identifies risk for cardiac death in patients with acute myocardial infarction

    DEFF Research Database (Denmark)

    Nielsen, J R; Mickley, H; Damsgaard, E M

    1990-01-01

    A maximal exercise test was performed in 54 patients with acute myocardial infarction (AMI) before discharge and in 49 age-matched control subjects. The long-term prognosis was assessed after an average follow-up of 7.6 years in AMI patients and 5.8 years in control subjects. The maximal work...... capacity and systolic blood pressure increase in AMI patients was 59% that of control subjects (p less than 0.001). Seventeen AMI patients had significant ST-segment shifts, 13 with ST depression and 4 with ST elevation. In AMI patients experiencing a cardiac death during follow-up the maximal work...... were of no significant value. In this study maximal work capacity turned out to be the best single exercise variable for identifying groups of AMI patients with very low and relative high risk of cardiac death. When all 3 exercise variables were combined, the predischarge maximal exercise test...

  13. Effects of calcium ion concentration on starch hydrolysis of barley α-amylase isozymes

    DEFF Research Database (Denmark)

    Yuk, Jeong-Bin; Choi, Seung-Ho; Lee, Tae-Hee;

    2008-01-01

    Barley (x-amylase genes, amyl and amy2, were separately cloned into the expression vector of pPICZ alpha A and recombinant Pichia strains were established by homologous recombination. Both AMYs from Pichia shared almost identical hydrolysis patterns on short maltooligosaccharides to result...... in glucose, maltose, or maltotriose. Against insoluble blue starch, AMY1 showed the highest activity at 0.1-5 mM calcium concentration, whereas 15-20 mM was optimal for AMY2. On the hydrolysis of soluble starch, unexpectedly, there was no significant difference between AMYs with increase of calcium. However......, the relative activity on various starch substrates was significantly different between AMYs, which supports that the isozymes are clearly distinguished from each other on the basis of their unique preferences for substrates....

  14. Amylase, lipase, pancreatic isoamylase, and phospholipase A in diagnosis of acute pancreatitis.

    Science.gov (United States)

    Clavé, P; Guillaumes, S; Blanco, I; Nabau, N; Mercé, J; Farré, A; Marruecos, L; Lluís, F

    1995-08-01

    To determine the utility of serum amylase (AMY), lipase (Lp), pancreatic isoamylase (isoA), phospholipase A (PLA), and urine AMY in the diagnosis of acute pancreatitis, samples of serum and urine were obtained on admission and every day thereafter for 5 days from 384 patients with acute abdominal pain. Diagnostic accuracy, determined as the area under the receiver operating characteristic curve, was > 0.975 for serum AMY, Lp, isoA, and urine AMY. For each of these enzymes, a threshold value (twice to sixfold the upper limit of the reference values) offering diagnostic efficiency > 95% could be determined. In contrast, accuracy and efficiency of serum PLA were low. The profiles of these enzymes in acute pancreatitis decreased in a parallel fashion over 5 days except for PLA. We conclude that diagnostic utilities are similar for serum AMY, Lp, isoA, and urine AMY for acute pancreatitis, provided that an appropriate threshold is established.

  15. Immobilization of -Amylase onto Luffa operculata Fibers

    Directory of Open Access Journals (Sweden)

    Ricardo R. Morais

    2013-01-01

    Full Text Available A commercial amylase (amy was immobilized by adsorption onto Luffa operculata fibers (LOFs. The derivative LOF-amy presented capacity to hydrolyze starch continuously and repeatedly for over three weeks, preserving more than 80% of the initial activity. This system hydrolyzed more than 97% of starch during 5 min, at room temperature. LOF-amy was capable to hydrolyze starch from different sources, such as maize (93.96%, wheat (85.24%, and cassava (79.03%. A semi-industrial scale reactor containing LOF-amy was prepared and showed the same yield of the laboratory-scale system. After five cycles of reuse, the LOF-amy reactor preserved over 80% of the initial amylase activity. Additionally, the LOF-amy was capable to operate as a kitchen grease trap component in a real situation during 30 days, preserving 30% of their initial amylase activity.

  16. Percutaneous coronary intervention for acute myocardial infarction in elderly patients with renal dysfunction: results from the Korea Acute Myocardial Infarction Registry.

    Science.gov (United States)

    Lim, Sang Yup; Bae, Eun Hui; Choi, Joon Seok; Kim, Chang Seong; Ma, Seong Kwon; Ahn, Youngkeun; Jeong, Myung Ho; Kim, Weon; Woo, Jong Shin; Kim, Young Jo; Cho, Myeong Chan; Kim, Chong Jin; Kim, Soo Wan

    2013-07-01

    This study aimed to evaluate the effects of percutaneous coronary intervention (PCI) on short- and long-term major adverse cardiac events (MACE) in elderly (>75 yr old) acute myocardial infarction (AMI) patients with renal dysfunction. As part of Korea AMI Registry (KAMIR), elderly patients with AMI and renal dysfunction (GFRrenal dysfunction, PCI therapy yields favorable in-hospital and short-term and long-term MACE-free survival.

  17. Acute myocardial infarction mimicking squamous cell lung cancer with bone metastases due to hypercalcemia: a case report

    Institute of Scientific and Technical Information of China (English)

    FANG Chong-feng; XU Geng; CHEN Yang-xin

    2010-01-01

    @@ Acute myocardial infarction (AMI), the most severe coronary artery disease, is one of the most frequent cardiac emergencies, and early diagnosis and treatment are very important to decrease the subsequent cardiac adverse events such as malignant arrhythmia and sudden cardiac death. But in fact, lots of diseases are similar to AMI in clinical practice, of which the most common are myocarditis, pulmonary embolism in department of cardiology. Here we report a case of AMI-like squamous cell lung cancer with bone metastases.

  18. Optimized Information Transmission Scheduling Strategy Oriented to Advanced Metering Infrastructure

    OpenAIRE

    Weiming Tong; Xianji Jin; Lei Lu

    2013-01-01

    Advanced metering infrastructure (AMI) is considered to be the first step in constructing smart grid. AMI allows customers to make real-time choices about power utilization and enables power utilities to increase the effectiveness of the regional power grids by managing demand load during peak times and reducing unneeded power generation. These initiatives rely heavily on the prompt information transmission inside AMI. Aiming at the information transmission problem, this paper researches the ...

  19. Dicty_cDB: VSB406 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available GTVRKAIARVLTVFNQTQKNHLR XVYSKKSSSKIPTDLRYKKTRAIRRRLTNKQSKVVTLRVSKTATNFPQRVFAVKA*ici* milknkiy Translated Ami...RRLTNKQSKVVTLRVSKTATNFPQRVFAVKA*ici* milknkiy Homology vs CSM-cDNA Score E Sequences producing significant a

  20. 78 FR 33859 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-DIE Products...

    Science.gov (United States)

    2013-06-05

    ...; AMI Semiconductor, Oudenaarrde, Belgium; Avago Technologies, Singapore, Singapore; Infineon Technologies, AG, Munich, Germany; Freescale Semiconductor, Inc., Austin, TX; Philips Semiconductors, Inc.,...