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Sample records for hurricane ivan adam

  1. Hurricane Ivan Poster (September 15, 2004)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Ivan poster. Multi-spectral image from NOAA-16 shows Hurricane Ivan in the Gulf of Mexico on September 15, 2004. Poster size is 34"x30".

  2. Tropical Storm Frances/ Hurricane Ivan Situation Report, September 10, 2014 (10:00 AM EDT)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2004-09-10

    The report provides highlights related to impacts of Hurricane Frances and Hurricane Ivan in the Florida area. Sections on electric information, oil and gas information, county outage data, and a table for restoration targets/status are provided.

  3. Tropical Storm Frances and Hurricane Ivan Situation Report, September 9, 2004 (10:00 PM EDT)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2004-09-09

    The report provides highlights related to impacts of Hurricane Frances and Hurricane Ivan in the Florida area. Sections on electric information, oil and gas information, and county outage data are provided.

  4. Impact of Hurricane Ivan on pharmacies in Baldwin County, Alabama.

    Science.gov (United States)

    Azziz-Baumgartner, Eduardo; Wolkin, Amy; Sanchez, Carlos; Bayleyegn, Tesfaye; Young, Stacy; Kieszak, Stephanie; Oberst, Kathleen; Batts, Dahna; Thomas, Charles C; Rubin, Carol

    2005-01-01

    To evaluate the impact of Hurricane Ivan, which made landfall east of Mobile, Alabama, on September 16, 2004, on pharmacies in the affected areas. Retrospective cross-sectional analysis. Baldwin County, Alabama. Pharmacy community rapid-needs-assessment survey. 41 hospital and community (chain and independent) pharmacies. Posthurricane pharmacy hours of operations, prescription volumes, infrastructure damage, and prehurricane disaster planning. During the week of the hurricane, both chain and independent community pharmacies within the evacuation zone worked significantly fewer hours (46% and 49%, respectively) and dispensed significantly fewer prescriptions (37% and 52%) compared with the same week of the prior year. Overall, 40% of pharmacies depleted their supplies of certain medications (e.g., anxiolytics, antihypertensives). A total of 60% of the chain and independent pharmacies outside the evacuation zone closed because of loss of electricity, but pharmacies with a generator were significantly less likely to report having turned away patients. The proportion of pharmacies that had a disaster plan but turned away patients or rationed or ran out of medications was similar to that of pharmacies without a disaster plan. Although Hurricane Ivan primarily affected the operation of pharmacies within the evacuation zone, pharmacies in the surrounding area were also affected because of loss of power. Emergency management officials should evaluate the efficacy of specific guidelines outlined in disaster plans and identify ways to deliver essential medications to people in disaster-affected areas.

  5. EFFECTS OF HURRICANE IVAN ON WATER QUALITY IN PENSACOLA BAY, FL USA

    Science.gov (United States)

    Pensacola Bay was in the strong NE quadrant of Hurricane Ivan when it made landfall on September 16, 2004 as a category 3 hurricane on the Saffir-Simpson scale. We present data describing the timeline and maximum height of the storm surge, the extent of flooding of coastal land, ...

  6. EFFECTS OF HURRICANE IVAN ON WATER QUALITY IN PENSACOLA BAY, FL USA

    Science.gov (United States)

    Pensacola Bay was in the strong NE quadrant of Hurricane Ivan when it made landfall on September 16, 2004 as a category 3 hurricane on the Saffir-Simpson scale. We present data describing the timeline and maximum height of the storm surge, the extent of flooding of coastal land, ...

  7. Hurricane Ivan Aerial Photography: High-Resolution Imagery of the Florida Panhandle and Surrounding Regions After Landfall

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The imagery posted on this site is of the Florida panhandle and surrounding regions after Hurricane Ivan made landfall. The regions photographed range from Gulf...

  8. Ocean-Wave Coupled Modeling in COAMPS-TC: A Study of Hurricane Ivan (2004)

    Science.gov (United States)

    2013-08-15

    Hurricane Ivan (2004) 0603207N 73-9270-01-5 Travis A. Smith, Sue Chen, Timothy Campbell, Paul Martin, W. Erick Rogers, Sasa Gabersek, David Wang, Suzanne...Timothy Campbell a, Paul Martin a, W. Erick Rogers a, Saša Gaberšek b, David Wang a, Suzanne Carroll c, Richard Allard a aNaval Research Laboratory...the shelf currents followed Ekman dynamics with overlapping surface and bottom layers during Ivan’s approach and transitioned to a dominant surface

  9. Two-dimensional modelling of overwash at Santa Rosa Island during Hurricane Ivan

    Science.gov (United States)

    McCall, R. T.; van Thiel de Vries, J. S. M.; Roelvink, J. A.; van Dongeren, A. R.; Thompson, D. M.; Plant, N. G.

    2009-04-01

    Approximately 10% of the world's coastline consists of low-lying barrier coasts, which are susceptible to coastal flooding, dune overwash and breaching. Although several numerical cross shore models exist to calculate beach and dune profile change during storms, overwash and breaching are not necessarily incorporated. Additionally, these models assume longshore uniformity and therefore do not include longshore variation in for instance dune height, shoreline angle and wave conditions. In order to simulate overwash on a barrier island we use a new numerical model for the nearshore and coast called XBeach (Roelvink et al., ICCE 2008). This process-based and time dependent model solves coupled short and long wave propagation, sediment transport and morphology in 2DH. The model has a robust numerical scheme, allowing it to simulate flooding and drying, thereby removing the need for separate dry and wet domains and procedures. XBeach is used to model a section of Santa Rosa Island, Florida, during Hurricane Ivan in 2004. This island was heavily overwashed during the hurricane and breached in one location. The model is set-up using high resolution airborne LIDAR altimetry and bathymetry data and forced using surge and wave data from larger scale numerical models. The modelled final bed elevation is compared to airborne LIDAR data acquired three days after the storm. The results show that XBeach is capable of simulating the complex hydrodynamics that occur during extreme overwash events. It is shown that the model can recreate the morphological developments that occurred on the island during the storm and that the model has considerable quantitative skill in predicting the final bed elevation.

  10. Post-Hurricane Ivan coastal oblique aerial photographs collected from Crawfordville, Florida, to Petit Bois Island, Mississippi, September 17, 2004

    Science.gov (United States)

    Morgan, Karen L.M.; Krohn, M. Dennis; Peterson, Russell D.; Thompson, Philip R.; Subino, Janice A.

    2015-01-01

    The U.S. Geological Survey (USGS) conducts baseline and storm response photography missions to document and understand the changes in vulnerability of the Nation's coasts to extreme storms. On September 17, 2004, the USGS conducted an oblique aerial photographic survey from Crawfordville, Florida, to Petit Bois Island, Mississippi aboard a Piper Navajo Chieftain (aircraft) at an altitude of 500 feet (ft) and approximately 1,000 ft offshore. This mission was flown to collect post-Hurricane Ivan data for assessing incremental changes in the beach and nearshore area since the last survey in 2001, and the data can be used in the assessment of future coastal change.

  11. Characterization of rainfall distribution and flooding associated with U.S. landfalling tropical cyclones: Analyses of Hurricanes Frances, Ivan, and Jeanne (2004)

    Science.gov (United States)

    Villarini, Gabriele; Smith, James A.; Baeck, Mary Lynn; Marchok, Timothy; Vecchi, Gabriel A.

    2011-12-01

    Rainfall and flooding associated with landfalling tropical cyclones are examined through empirical analyses of three hurricanes (Frances, Ivan, and Jeanne) that affected large portions of the eastern U.S. during September 2004. Three rainfall products are considered for the analyses: NLDAS, Stage IV, and TMPA. Each of these products has strengths and weaknesses related to their spatio-temporal resolution and accuracy in estimating rainfall. Based on our analyses, we recommend using the Stage IV product when studying rainfall distribution in landfalling tropical cyclones due to its fine spatial and temporal resolutions (about 4-km and hourly) and accuracy, and the capability of estimating rainfall up to 150 km from the coast. Lagrangian analyses of rainfall distribution relative to the track of the storm are developed to represent evolution of the temporal and spatial structure of rainfall. Analyses highlight the profound changes in rainfall distribution near landfall, the changing contributions to the rainfall field from eyewall convection, inner rain bands and outer rain bands, and the key role of orographic amplification of rainfall. We also present new methods for examining spatial extreme of flooding from tropical cyclones and illustrate the links between evolving rainfall structure and spatial extent of flooding.

  12. Geologic, geomorphic, and meteorological aspects of debris flows triggered by Hurricanes Frances and Ivan during September 2004 in the Southern Appalachian Mountains of Macon County, North Carolina (southeastern USA)

    Science.gov (United States)

    Wooten, R.M.; Gillon, K.A.; Witt, A.C.; Latham, R.S.; Douglas, T.J.; Bauer, J.B.; Fuemmeler, S.J.; Lee, L.G.

    2008-01-01

    In September 2004, rain from the remnants of Hurricanes Frances and Ivan triggered at least 155 landslides in the Blue Ridge Mountains of North Carolina. At least 33 debris flows occurred in Macon County, causing 5 deaths, destroying 16 homes, and damaging infrastructure. We mapped debris flows and debris deposits using a light-detecting and ranging digital elevation model, remote imagery and field studies integrated in a geographic information system. Evidence of past debris flows was found at all recent debris flow sites. Orographic rainfall enhancement along topographic escarpments influenced debris flow frequency at higher elevations. A possible trigger for the Wayah and fatal Peeks Creek debris flows was a spiral rain band within Ivan that moved across the area with short duration rainfall rates of 150-230 mm/h. Intersecting bedrock structures in polydeformed metamorphic rock influence the formation of catchments within structural-geomorphic domains where debris flows originate. ?? 2007 Springer-Verlag.

  13. 2004 Landfalling Hurricanes Poster

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 2004 U.S. Landfalling Hurricanes poster is a special edition poster which contains two sets of images of Hurricanes Charley, Frances, Ivan, and Jeanne, created...

  14. Caring for Ivan Ilyich.

    Science.gov (United States)

    Charlton, Blake; Verghese, Abraham

    2010-01-01

    For over a century, Leo Tolstoy's The Death of Ivan Ilych has been one of the most influential examinations of how we come to terms with our own mortality. Of the many who care for Ivan Ilych, only the uneducated peasant, Gerasim, is able to help him find meaning and resolution before death. An excerpt that describes Gerasim's key interaction with Ivan Ilych is provided. Analysis of the text reveals how cultural values may hinder a patient's ability to confront mortality and how unique social barriers inhibit different caretakers' ability to care for a dying patient.

  15. Intervista a Ivan Fedele

    Directory of Open Access Journals (Sweden)

    Marco Ligabue

    2010-12-01

    Full Text Available The interview to Ivan Fedele – which opens this number of Music / Technology as ‘provoking’ element – expresses the composer’s attitude towards technology – mainly found in computer music –, the use he made within his work, as well as the developments generally considered harbingers of more interesting perspectives for the future. Several passages stress the primacy of the compositional idea on the technological means and the need of the composer to maintain control of the situation without giving up the prerogatives of the medium; indeed, it must be ‘bent’ – if not specifically designed – to the requirements of the compositional idea.

  16. Ivan Groznõi vozvrashtshajetsja! / Jaroslav Shtshedrov

    Index Scriptorium Estoniae

    Shtshedrov, Jaroslav

    2008-01-01

    Vene režissöör Pavel Lungin koos operaator Tom Sterniga alustasid Suzdalis mängufilmi "Ivan Groznõi ja metrpoliit Filipp" võtteid. Osalevad Pjotr Mamonov (Ivan IV), Oleg Jankovski (Filipp), Ivan Ohlobõstin, Aleksandr Domogarov jt

  17. Hurricane Safety

    Science.gov (United States)

    ... English Hurricane Safety Checklist - Arabic Hurricane Safety Checklist - Chinese Hurricane Safety Checklist - French Hurricane Safety Checklist - Haitian ... Cross serves in the US, its territories and military installations around the world. Please try again. Your ...

  18. Arhitektuuri Meka - R'dam? / Ivan Sergejev

    Index Scriptorium Estoniae

    Sergejev, Ivan

    2009-01-01

    Rotterdamis Erick van Egeraati arhitektuuribüroos praktikal olnud Ivan Sergejev arhitektuurile orienteeritud Rotterdamist, linnas asuvatest arhitektuurifirmadest ja -koolidest, vaatamisväärsustest, ehitamisel olevatest hoonetest. 14. mail 1940 hävinud Rotterdami ei taastatud, vaid ehitati uus linn

  19. Arhitektuuri Meka - R'dam? / Ivan Sergejev

    Index Scriptorium Estoniae

    Sergejev, Ivan

    2009-01-01

    Rotterdamis Erick van Egeraati arhitektuuribüroos praktikal olnud Ivan Sergejev arhitektuurile orienteeritud Rotterdamist, linnas asuvatest arhitektuurifirmadest ja -koolidest, vaatamisväärsustest, ehitamisel olevatest hoonetest. 14. mail 1940 hävinud Rotterdami ei taastatud, vaid ehitati uus linn

  20. Forecasting hurricane impact on coastal topography: Hurricane Ike

    Science.gov (United States)

    Plant, Nathaniel G.; Stockdon, Hilary F.; Sallenger,, Asbury H.; Turco, Michael J.; East, Jeffery W.; Taylor, Arthur A.; Shaffer, Wilson A.

    2010-01-01

    Extreme storms can have a profound impact on coastal topography and thus on ecosystems and human-built structures within coastal regions. For instance, landfalls of several recent major hurricanes have caused significant changes to the U.S. coastline, particularly along the Gulf of Mexico. Some of these hurricanes (e.g., Ivan in 2004, Katrina and Rita in 2005, and Gustav and Ike in 2008) led to shoreline position changes of about 100 meters. Sand dunes, which protect the coast from waves and surge, eroded, losing several meters of elevation in the course of a single storm. Observations during these events raise the question of how storm-related changes affect the future vulnerability of a coast.

  1. Un poema epico neolatino su Ivan Mazepa

    Directory of Open Access Journals (Sweden)

    Giovanna Siedina

    2007-12-01

    Full Text Available A Neo-Latin Poem on Ivan Mazepa The author publishes for the first time, translates into Italian, and analyzes a Neo-Latin poem devoted to the Ukrainian hetman Ivan Mazepa, which celebrates the conquest of a few Turkish fortresses along the Dnipro (1695. A peculiar feature of this poem is that, on the one side, it is one of the few, or even the only epic poem devoted to the Ukrainian hetman, while on the other it is modeled, at least partly, on Virgil’s Aeneid. The poem, however, also shows some features of the panegyric genre. The author points out the many linguistic-literary and historical reminiscences, especially those of Latin epic authors and Roman history, but also of the panegyric discourse elaborated by the Latin-Polish rhetorical tradition. Through these reminiscences, the author of the poem aspires to insert the history of Ukraine-Hetmanščyna into the European Latinitas by underlining the glorious deeds of its hetman Ivan Mazepa, whose fundamental contribution to the antemurale christianitatis and to Russian history only recently has begun to be assessed in an objective and unprejudiced manner.

  2. Hydrometeor and latent heat profiles of tropical cyclones Conson, Ivan and Catarina using PR/TRMM data Perfis de hidrometeoros e de calor latente dos ciclones tropicais Conson, Ivan e Catarina usando dados do PR/TRMM

    Directory of Open Access Journals (Sweden)

    Marcelo Barbio Rosa

    2010-06-01

    Full Text Available ABSTRACT Microphysical and thermodynamical features of two tropical systems, namely Hurricane Ivan and Typhoon Conson, and one sub-tropical, Catarina, have been analyzed based on space-born radar PR measurements available on the TRMM satellite. The procedure to classify the reflectivity profiles followed the Heymsfield et al (2000 and Steiner et al (1995 methodologies. The water and ice content have been calculated using a relationship obtained with data of the surface SPOL radar and PR in Rondonia State in Brazil. The diabatic heating rate due to latent heat release has been estimated using the methodology developed by Tao et al (1990. A more detailed analysis has been performed for Hurricane Catarina, the first of its kind in South Atlantic. High water content mean value has been found in Conson and Ivan at low levels and close to their centers. Results indicate that hurricane Catarina was shallower than the other two systems, with less water and the water was concentrated closer to its center. The mean ice content in Catarina was about 0.05 g kg-1 while in Conson it was 0.06 g kg-1 and in Ivan 0.08 g kg-1. Conson and Ivan had water content up to 0.3 g kg-1 above the 0ºC layer, while Catarina had less than 0.15 g kg-1. The latent heat released by Catarina showed to be very similar to the other two systems, except in the regions closer to the center.No presente trabalho foram analisados as características microfísicas e termodinâmicas de dois sistemas tropicais, o Furacão Ivan e o Tufão Conson, e um sub-tropical, Catarina, a partir de medições feitas com o radar PR a bordo do satélite TRMM. Na análise, os perfis de refletividade foram classificados conforme as técnicas de Heymsfield et al (2000 e Steiner et al (1995 e em seguida foram calculados os conteúdos de água e gelo, a partir de uma relação obtida no Estado de Rondônia (Brasil. Com estes perfis calculou-se a taxa de aquecimento diabático devido a liberação de calor

  3. Impact of Hurricane Exposure on Reproductive Health Outcomes, Florida, 2004.

    Science.gov (United States)

    Grabich, Shannon C; Robinson, Whitney R; Konrad, Charles E; Horney, Jennifer A

    2017-08-01

    Prenatal hurricane exposure may be an increasingly important contributor to poor reproductive health outcomes. In the current literature, mixed associations have been suggested between hurricane exposure and reproductive health outcomes. This may be due, in part, to residual confounding. We assessed the association between hurricane exposure and reproductive health outcomes by using a difference-in-difference analysis technique to control for confounding in a cohort of Florida pregnancies. We implemented a difference-in-difference analysis to evaluate hurricane weather and reproductive health outcomes including low birth weight, fetal death, and birth rate. The study population for analysis included all Florida pregnancies conceived before or during the 2003 and 2004 hurricane season. Reproductive health data were extracted from vital statistics records from the Florida Department of Health. In 2004, 4 hurricanes (Charley, Frances, Ivan, and Jeanne) made landfall in rapid succession; whereas in 2003, no hurricanes made landfall in Florida. Overall models using the difference-in-difference analysis showed no association between exposure to hurricane weather and reproductive health. The inconsistency of the literature on hurricane exposure and reproductive health may be in part due to biases inherent in pre-post or regression-based county-level comparisons. We found no associations between hurricane exposure and reproductive health. (Disaster Med Public Health Preparedness. 2017;11:407-411).

  4. Adam Smith, Behavioral Economist

    National Research Council Canada - National Science Library

    Ashraf, Nava; Camerer, Colin F; Loewenstein, George

    2005-01-01

    Adam Smith's psychological perspective in The Theory of Moral Sentiments is remarkably similar to "dual-process" frameworks advanced by psychologists, neuroscientists, and more recently by behavioral...

  5. Ivan Yakovych Gorbachevsky – Scientist, Patriot, Citizen

    Directory of Open Access Journals (Sweden)

    V. M. Danilova

    2014-10-01

    Full Text Available The article presents the facts about life and research activity of Ivan Ya. Gorbachevsky (1854-1942, the prominent scientist, Ukrainian by origin, doctor of medical sciences, professor, dean of the medical faculty and the rector of Charles University in Prague, member of the health board of the Czech Kingdom, a member of the Supreme Council of Health of Austria-Hungary in Vienna, a lifelong member of the House of Lords of the Austrian Parliament, first health minister of Austria-Hungary, rector of the Ukrainian Free University in Prague, professor of chemistry at the Padebradsk Economic Academy and the Ukrainian Pedagogical Dragomanov University, AUAS member in 1925, member of the Shevchenko Scientific Society. His research works were devoted to digestion of proteins, public and food hygiene. He was the first who synthesized uric acid (1882 and discovered xanthine oxidase (1889.

  6. Hurricane Katrina Wind Investigation Report

    Energy Technology Data Exchange (ETDEWEB)

    Desjarlais, A. O.

    2007-08-15

    This investigation of roof damage caused by Hurricane Katrina is a joint effort of the Roofing Industry Committee on Weather Issues, Inc. (RICOWI) and the Oak Ridge National Laboratory/U.S. Department of Energy (ORNL/DOE). The Wind Investigation Program (WIP) was initiated in 1996. Hurricane damage that met the criteria of a major windstorm event did not materialize until Hurricanes Charley and Ivan occurred in August 2004. Hurricane Katrina presented a third opportunity for a wind damage investigation in August 29, 2005. The major objectives of the WIP are as follows: (1) to investigate the field performance of roofing assemblies after major wind events; (2) to factually describe roofing assembly performance and modes of failure; and (3) to formally report results of the investigations and damage modes for substantial wind speeds The goal of the WIP is to perform unbiased, detailed investigations by credible personnel from the roofing industry, the insurance industry, and academia. Data from these investigations will, it is hoped, lead to overall improvement in roofing products, systems, roofing application, and durability and a reduction in losses, which may lead to lower overall costs to the public. This report documents the results of an extensive and well-planned investigative effort. The following program changes were implemented as a result of the lessons learned during the Hurricane Charley and Ivan investigations: (1) A logistics team was deployed to damage areas immediately following landfall; (2) Aerial surveillance--imperative to target wind damage areas--was conducted; (3) Investigation teams were in place within 8 days; (4) Teams collected more detailed data; and (5) Teams took improved photographs and completed more detailed photo logs. Participating associations reviewed the results and lessons learned from the previous investigations and many have taken the following actions: (1) Moved forward with recommendations for new installation procedures

  7. Hurricane Katrina Wind Investigation Report

    Energy Technology Data Exchange (ETDEWEB)

    Desjarlais, A. O.

    2007-08-15

    This investigation of roof damage caused by Hurricane Katrina is a joint effort of the Roofing Industry Committee on Weather Issues, Inc. (RICOWI) and the Oak Ridge National Laboratory/U.S. Department of Energy (ORNL/DOE). The Wind Investigation Program (WIP) was initiated in 1996. Hurricane damage that met the criteria of a major windstorm event did not materialize until Hurricanes Charley and Ivan occurred in August 2004. Hurricane Katrina presented a third opportunity for a wind damage investigation in August 29, 2005. The major objectives of the WIP are as follows: (1) to investigate the field performance of roofing assemblies after major wind events; (2) to factually describe roofing assembly performance and modes of failure; and (3) to formally report results of the investigations and damage modes for substantial wind speeds The goal of the WIP is to perform unbiased, detailed investigations by credible personnel from the roofing industry, the insurance industry, and academia. Data from these investigations will, it is hoped, lead to overall improvement in roofing products, systems, roofing application, and durability and a reduction in losses, which may lead to lower overall costs to the public. This report documents the results of an extensive and well-planned investigative effort. The following program changes were implemented as a result of the lessons learned during the Hurricane Charley and Ivan investigations: (1) A logistics team was deployed to damage areas immediately following landfall; (2) Aerial surveillance--imperative to target wind damage areas--was conducted; (3) Investigation teams were in place within 8 days; (4) Teams collected more detailed data; and (5) Teams took improved photographs and completed more detailed photo logs. Participating associations reviewed the results and lessons learned from the previous investigations and many have taken the following actions: (1) Moved forward with recommendations for new installation procedures

  8. Det Syriske Adams Testamente

    DEFF Research Database (Denmark)

    Holst, Søren; Christensen, Peter; Kristensen, Stefan;

    2015-01-01

    Artiklen præsenterer en dansk oversættelse af det ældste bevarede manuskript af det syriske Adams Testamente, samt en introduktion og diskussion af centrale aspekter af skriftets sprog og teologi, såsom fortolkningen af begivenhederne i Edens have, den forbudne frugt, Adams fremtidige skæbne og de...

  9. Det Syriske Adams Testamente

    DEFF Research Database (Denmark)

    Holst, Søren; Christensen, Peter; Kristensen, Stefan

    2015-01-01

    Artiklen præsenterer en dansk oversættelse af det ældste bevarede manuskript af det syriske Adams Testamente, samt en introduktion og diskussion af centrale aspekter af skriftets sprog og teologi, såsom fortolkningen af begivenhederne i Edens have, den forbudne frugt, Adams fremtidige skæbne og de...

  10. Hurricane Season

    Institute of Scientific and Technical Information of China (English)

    JENNIFER; JETT

    2008-01-01

    Three years after Katrina,the United States isdetermined not to repeatits mistakes This year has seen an unusually activeand deadly hurricane season, asstorms line up in the Atlantic Oceanto pummel the Caribbean and UnitedStates coastline.

  11. Ansel Adams: early works

    Science.gov (United States)

    Throckmorton, Jodi

    2010-02-01

    Ansel Adams (1902-1984), photographer, musician, naturalist, explorer, critic, and teacher, was a giant in the field of landscape photography. In his images of the unspoiled Western landscape, he strove to capture the sublime: the transcendentalist concept that nature can generate the experience of awe for the viewer. Many viewers are familiar with the heroic, high-contrast prints on high-gloss paper that Adams made to order beginning in the 1970s; much less well known are the intimate prints that the artist crafted earlier in his career. This exhibition focuses on these masterful small prints from the 1920s into the 1950s. During this time period, Adams's printing style changed dramatically. The painterly, soft-focus, warm-toned style of the Parmelian Prints of the High Sierras from the 1920s evolved into the sharp-focus style of the f/64 school of photography that Adams co-founded in the 1930s with Edward Weston and Imogen Cunningham. After World War II, Adams opted for a cooler, higher-contrast look for his prints. Throughout the various styles in which he chose to work, Adams explored the power of nature and succeeded in establishing landscape photography as a legitimate form of modern art.

  12. Kangur Ivan ajab triipu, naised lähevad arust ära / Rein Sikk

    Index Scriptorium Estoniae

    Sikk, Rein, 1961-

    2011-01-01

    Ivan Uvarovist, kes koob oma pisikeses töökojas Rakveres rahvarõivamustritega puuvillast triibukangast, mille järele on suur nõudmine. Ivan Uvarov on töötanud 30 aastat kangastelgede mehaanikuna

  13. Female hurricanes are deadlier than male hurricanes.

    Science.gov (United States)

    Jung, Kiju; Shavitt, Sharon; Viswanathan, Madhu; Hilbe, Joseph M

    2014-06-17

    Do people judge hurricane risks in the context of gender-based expectations? We use more than six decades of death rates from US hurricanes to show that feminine-named hurricanes cause significantly more deaths than do masculine-named hurricanes. Laboratory experiments indicate that this is because hurricane names lead to gender-based expectations about severity and this, in turn, guides respondents' preparedness to take protective action. This finding indicates an unfortunate and unintended consequence of the gendered naming of hurricanes, with important implications for policymakers, media practitioners, and the general public concerning hurricane communication and preparedness.

  14. Inspired by Deschooling: An Appreciation of Ivan Illich.

    Science.gov (United States)

    Spaventa, Lou

    2003-01-01

    Discusses the work and beliefs of Ivan Illich and how these have influenced one English-as-a-Second-Language teacher's and kept him thinking about his work as an educator. Uses Illich's favorite metaphor--that of weaving a web--to illustrate how he tries to find an interconnectedness between himself and each of his students. (Author/VWL)

  15. Deschooling and the Web: Ivan Illich 30 Years On.

    Science.gov (United States)

    Hart, Ian

    2001-01-01

    Examines Ivan Illich's ideas for replacing institutionalized schooling with community-driven opportunity webs that would enable learners to be in control of their own learning and that would allow teachers to offer their services in an entrepreneurial fashion. Considers how the World Wide Web has created opportunities for those ideas. (Author/LRW)

  16. Ivan Doig: Northwestern Writer for Secondary Students (Reclaiming the Canon).

    Science.gov (United States)

    Zirinsky, Driek; Morache, Jette

    1989-01-01

    Reviews two books by Ivan Doig: "This House of Sky: Landscapes of a Western Mind" and "English Creek." Notes that both books provide a picture of life in the American West that is not pervaded by Western stereotypes of cowboys and Indians. (MM)

  17. Was Adam a Real Person?

    Science.gov (United States)

    Lamoureux, Denis O.

    2011-01-01

    Belief in the historicity of Adam has been held firmly throughout the history of the church. In the light of modern biblical criticism and the evolutionary sciences, some conservative Christians are now questioning whether or not Adam was a real person. This paper argues that the existence of Adam in the opening chapters of scripture reflects an…

  18. Adams Operations on Matrix Factorizations

    OpenAIRE

    Brown, Michael K.; Miller, Claudia; Thompson, Peder; Walker, Mark E.

    2016-01-01

    We define Adams operations on matrix factorizations, and we show these operations enjoy analogues of several key properties of the Adams operations on perfect complexes with support developed by Gillet-Soul\\'e in their paper "Intersection Theory Using Adams Operations". As an application, we give a proof of a conjecture of Dao-Kurano concerning the vanishing of Hochster's theta invariant.

  19. The Adams Family

    Science.gov (United States)

    Douven, Igor; Verbrugge, Sara

    2010-01-01

    According to Adams's Thesis, the acceptability of an indicative conditional sentence goes by the conditional probability of its consequent given its antecedent. We test, for the first time, whether this thesis is descriptively correct and show that it is not; in particular, we show that it yields the wrong predictions for people's judgments of the…

  20. The Adams family

    NARCIS (Netherlands)

    Douven, Igor; Verbrugge, Sara

    2010-01-01

    According to Adams's Thesis, the acceptability of an indicative conditional sentence goes by the conditional probability of its consequent given its antecedent. We test, for the first time, whether this thesis is descriptively correct and show that it is not; in particular, we show that it yields th

  1. ADAM and EVA

    CERN Multimedia

    CERN PhotoLab

    1971-01-01

    Some units of ADAM and EVA, the scanning and measuring system for photographs taken in the Mirabelle hydrogen bubble chamber. On the right are film transport systems and projectors. The table where views are projected in front of the operator is situated below on the next floor of the building. On the left are the control electronics, the PDP8/L

  2. Hurricane Resource Reel

    Data.gov (United States)

    National Aeronautics and Space Administration — This Reel Includes the Following Sections TRT 50:10 Hurricane Overviews 1:02; Hurricane Arthur 15:07; Cyclone Pam 19:48; Typhoon Hagupit 21:27; Hurricane Bertha...

  3. Hurricane Evacuation Routes

    Data.gov (United States)

    Department of Homeland Security — Hurricane Evacuation Routes in the United States A hurricane evacuation route is a designated route used to direct traffic inland in case of a hurricane threat. This...

  4. Hurricane Science

    Science.gov (United States)

    Emanuel, Kerry

    2012-10-01

    Hurricanes provide beautiful examples of many of the key physical processes important in geophysical systems. They are rare natural examples of nearly perfect Carnot heat engines with an interesting wrinkle: They recycle much of their waste heat into the front end of the engine, thereby achieving greater wind speeds than would otherwise be possible. They are driven by surface enthalpy fluxes made possible by the thermodynamic disequilibrium between the earth's surface and atmosphere, a characteristic of radiative equilibrium in the presence of greenhouse gases. Their evolution, structure, and intensity all depend on turbulence near the ocean surface and in the outflow layer of the storm, high up in the atmosphere. In the course of this banquet, I will briefly describe these and other interesting aspects of hurricane physics, and also describe the role these storms have played in human history.

  5. ADAM Proteases and Gastrointestinal Function.

    Science.gov (United States)

    Jones, Jennifer C; Rustagi, Shelly; Dempsey, Peter J

    2016-01-01

    A disintegrin and metalloproteinases (ADAMs) are a family of cell surface proteases that regulate diverse cellular functions, including cell adhesion, migration, cellular signaling, and proteolysis. Proteolytically active ADAMs are responsible for ectodomain shedding of membrane-associated proteins. ADAMs rapidly modulate key cell signaling pathways in response to changes in the extracellular environment (e.g., inflammation) and play a central role in coordinating intercellular communication within the local microenvironment. ADAM10 and ADAM17 are the most studied members of the ADAM family in the gastrointestinal tract. ADAMs regulate many cellular processes associated with intestinal development, cell fate specification, and the maintenance of intestinal stem cell/progenitor populations. Several signaling pathway molecules that undergo ectodomain shedding by ADAMs [e.g., ligands and receptors from epidermal growth factor receptor (EGFR)/ErbB and tumor necrosis factor α (TNFα) receptor (TNFR) families] help drive and control intestinal inflammation and injury/repair responses. Dysregulation of these processes through aberrant ADAM expression or sustained ADAM activity is linked to chronic inflammation, inflammation-associated cancer, and tumorigenesis.

  6. ADAM Proteases and Gastrointestinal Function

    Science.gov (United States)

    Jones, Jennifer C.; Rustagi, Shelly; Dempsey, Peter J.

    2016-01-01

    A disintegrin and metalloproteinases (ADAMs) are a family of cell surface proteases that regulate diverse cellular functions, including cell adhesion, migration, cellular signaling, and proteolysis. Proteolytically active ADAMs are responsible for ectodomain shedding of membrane-associated proteins. ADAMs rapidly modulate key cell signaling pathways in response to changes in the extracellular environment (e.g., inflammation) and play a central role in coordinating intercellular communication within the local microenvironment. ADAM10 and ADAM17 are the most studied members of the ADAM family in the gastrointestinal tract. ADAMs regulate many cellular processes associated with intestinal development, cell fate specification, and the maintenance of intestinal stem cell/progenitor populations. Several signaling pathway molecules that undergo ectodomain shedding by ADAMs [e.g., ligands and receptors from epidermal growth factor receptor (EGFR)/ErbB and tumor necrosis factor α (TNFα) receptor (TNFR) families] help drive and control intestinal inflammation and injury/repair responses. Dysregulation of these processes through aberrant ADAM expression or sustained ADAM activity is linked to chronic inflammation, inflammation-associated cancer, and tumorigenesis. PMID:26667078

  7. The role of ADAMs in disease pathophysiology.

    LENUS (Irish Health Repository)

    Duffy, Michael J

    2012-02-01

    The ADAMs are a family of multidomain transmembrane and secreted proteins involved in both proteolysis and cell adhesion. Altered expression of specific ADAMs is implicated in the pathophysiology of several diseases including rheumatoid arthritis, Alzheimer\\'s disease, cardiac hypertrophy, asthma and cancer. Of these different diseases, it is in cancer where most research has been carried out. Multiple ADAMs, including ADAM-9, ADAM-10, ADAM-12, ADAM-15 and ADAM-17, have been shown to play a role in either cancer formation or progression. Consistent with these findings, increased expression of specific ADAMs in several cancer types was found to correlate with features of aggressive disease and poor prognosis. Currently, selective ADAM inhibitors against ADAM-10 and ADAM-17 are undergoing clinical trials for the treatment of cancer. Further work is required in order to establish a causative role for ADAMs in rheumatoid arthritis, Alzheimer\\'s disease, cardiac hypertrophy and asthma.

  8. County-level hurricane exposure and birth rates: application of difference-in-differences analysis for confounding control.

    Science.gov (United States)

    Grabich, Shannon C; Robinson, Whitney R; Engel, Stephanie M; Konrad, Charles E; Richardson, David B; Horney, Jennifer A

    2015-01-01

    Epidemiological analyses of aggregated data are often used to evaluate theoretical health effects of natural disasters. Such analyses are susceptible to confounding by unmeasured differences between the exposed and unexposed populations. To demonstrate the difference-in-difference method our population included all recorded Florida live births that reached 20 weeks gestation and conceived after the first hurricane of 2004 or in 2003 (when no hurricanes made landfall). Hurricane exposure was categorized using ≥74 mile per hour hurricane wind speed as well as a 60 km spatial buffer based on weather data from the National Oceanic and Atmospheric Administration. The effect of exposure was quantified as live birth rate differences and 95 % confidence intervals [RD (95 % CI)]. To illustrate sensitivity of the results, the difference-in-differences estimates were compared to general linear models adjusted for census-level covariates. This analysis demonstrates difference-in-differences as a method to control for time-invariant confounders investigating hurricane exposure on live birth rates. Difference-in-differences analysis yielded consistently null associations across exposure metrics and hurricanes for the post hurricane rate difference between exposed and unexposed areas (e.g., Hurricane Ivan for 60 km spatial buffer [-0.02 births/1000 individuals (-0.51, 0.47)]. In contrast, general linear models suggested a positive association between hurricane exposure and birth rate [Hurricane Ivan for 60 km spatial buffer (2.80 births/1000 individuals (1.94, 3.67)] but not all models. Ecological studies of associations between environmental exposures and health are susceptible to confounding due to unmeasured population attributes. Here we demonstrate an accessible method of control for time-invariant confounders for future research.

  9. Observed Oceanic Response over the Upper Continental Slope and Outer Shelf during Hurricane Ivan

    Science.gov (United States)

    2007-09-01

    Tide recorders (SBE Workhorse ADCPs operating at 300 kHz and Sea-Bird 26 SEAGAUGE) measured near-bottom pressure ( Ph ) Electronics wave/tide gauges. The...Verlag, 710 pp. Teague, W. J., E. Jarosz, M. R. Carnes , D. A. Mitchell, and P. J. Perkins, H., F. De Strobel, and L. Gauldesi, 2000: The barny Hogan

  10. Nesting the Gulf of Mexico in Atlantic HYCOM: Oceanographic Processes Generated by Hurricane Ivan

    Science.gov (United States)

    2008-01-01

    of the National Data Sea using HYCOM. J. Phys. Oceanogr. 35, 33-54. Buoy Center. This paper is NRL contribution number Large, W.G., McWilliams , J.C...Doney, S.C., 1994. Oceanic vertical NRL/JA/7320-07-7185. Thanks are extended to Dr. Alan mixing: a review and a model with a nonlocal boundary layer

  11. John Adams in 1959

    CERN Multimedia

    1959-01-01

    On 24 November 1959, the Proton Synchrotron accelerated particles to 24 GeV. John Adams, leader of the construction team, announced the achievement in the Main Auditorium. In his hand can be seen an empty vodka bottle, which he had received from Nikitin with the message that it was to be drunk when CERN passed Dubna's world record energy of 10 Gev. The bottle now contains a polaroid photograph of the 24 GeV pulse ready to be sent to the Soviet Union.

  12. New Mathematical Dimensions: Adam's Story

    Science.gov (United States)

    Manizade, Agida

    2009-01-01

    Adam, an 11th grader, was identified as gifted and accepted into a two week summer enrichment program. He signed up for "Geometry with Flash Programming." He had no prior programming experience but had a strong and healthy self-image as mathematics student. Although Adam had a positive attitude toward mathematics and saw himself as a successful…

  13. Changing Perceptions in "Adam Bede."

    Science.gov (United States)

    Loges, Max L.

    From the very beginning of "Adam Bede," the idea of sight or perception is emphasized. Indeed by reference to a quotation from Wordsworth, George Eliot announces the purpose of the novel: to reveal clearly, to remove from the shade. While most of the characters in "Adam Bede" do not perceive events clearly and must have their erroneous opinions…

  14. Brecht e Ivan Lins: Um diálogo intertextual

    Directory of Open Access Journals (Sweden)

    Eloá Heise

    2000-11-01

    Full Text Available Das Thema dieses Aufsatzes betrifft die Verbindungen und Wechselwirkungen zwischen Dichtern und ihren Werken über sprachliche und politische Grenzen hinweg. Am Beispiel von Brechts Gedicht An die Nachgeborenen (1938 und des Songs Aos nossos filhos (An unsere Kinder - Ende der 70er Jahre von Ivan Lins und Vitor Martins wird gezeigt, daß die Interpretation nicht auf eine immanente Perspektive beschränkt werden kann. Um eine angemessene Analyse geben zu können, ist es notwendig, den historischen und sozio-politischen Kontext in Betracht zu ziehen.

  15. FOLK DWELLING IN THE NOVEL OF IVAN BAHRIANYI "TYHROLOVY"

    Directory of Open Access Journals (Sweden)

    BOGUSLAVSKAYA L. G.

    2016-07-01

    Full Text Available Statement of the problem. The image of the national home contains a number of basic characteristics on the basis of which can be traced specifically to the national vision and principles of human connections with the material world. In the novel "Tyhrolovy" the uniqueness of this play lies in the fact that the “Ukrainian Khata” consolidated among the "alien" space. On the pages of the novel takes place already well-established, self-sufficient and organized life of an Ukrainian family that not only survived, but also learned new vital dimension. Folk housing in the context appears as the main object of maintaining tribal affiliation to the Ukrainian land. The purpose of the article. To perform the folk characteristic properties at home in the works of Ivan Bahrianyi. Conclusions. Roman "Tyhrolovy" Ivan Bahrianyi contains a number of significant parts filled with the symbols of tribal affiliation to the Ukrainian world. In particular, fully preserved and carefully restored in the family home of Sirko the guard function of these important components of the domestic home space, like images, embroidered towels, oven painted with flowers, carved cupboard. A combination feature of former agricultural world with the world of game is transmitted via the zoomorphic elements of the painting ovens ( former peace doves have become falcons and deploying a visual of the number of images that are typical for Ukrainian dwelling as the basic form of fixation of life and family development.

  16. 2005 Atlantic Hurricanes Poster

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 2005 Atlantic Hurricanes poster features high quality satellite images of 15 hurricanes which formed in the Atlantic Basin (includes Gulf of Mexico and Caribbean...

  17. Hurricane Gustav Poster

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Gustav poster. Multi-spectral image from NOAA-17 shows Hurricane Gustav having made landfall along the Louisiana coastline. Poster size is 36"x27"

  18. Hurricane Ike Poster

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Ike poster. Multi-spectral image from NOAA-15 shows Hurricane Ike in the Gulf of Mexico heading toward Galveston Island, Texas. Poster size is 36"x27".

  19. Evolution of Vertebrate Adam Genes; Duplication of Testicular Adams from Ancient Adam9/9-like Loci.

    Science.gov (United States)

    Bahudhanapati, Harinath; Bhattacharya, Shashwati; Wei, Shuo

    2015-01-01

    Members of the disintegrin metalloproteinase (ADAM) family have important functions in regulating cell-cell and cell-matrix interactions as well as cell signaling. There are two major types of ADAMs: the somatic ADAMs (sADAMs) that have a significant presence in somatic tissues, and the testicular ADAMs (tADAMs) that are expressed predominantly in the testis. Genes encoding tADAMs can be further divided into two groups: group I (intronless) and group II (intron-containing). To date, tAdams have only been reported in placental mammals, and their evolutionary origin and relationship to sAdams remain largely unknown. Using phylogenetic and syntenic tools, we analyzed the Adam genes in various vertebrates ranging from fishes to placental mammals. Our analyses reveal duplication and loss of some sAdams in certain vertebrate species. In particular, there exists an Adam9-like gene in non-mammalian vertebrates but not mammals. We also identified putative group I and group II tAdams in all amniote species that have been examined. These tAdam homologues are more closely related to Adams 9 and 9-like than to other sAdams. In all amniote species examined, group II tAdams lie in close vicinity to Adam9 and hence likely arose from tandem duplication, whereas group I tAdams likely originated through retroposition because of their lack of introns. Clusters of multiple group I tAdams are also common, suggesting tandem duplication after retroposition. Therefore, Adam9/9-like and some of the derived tAdam loci are likely preferred targets for tandem duplication and/or retroposition. Consistent with this hypothesis, we identified a young retroposed gene that duplicated recently from Adam9 in the opossum. As a result of gene duplication, some tAdams were pseudogenized in certain species, whereas others acquired new expression patterns and functions. The rapid duplication of Adam genes has a major contribution to the diversity of ADAMs in various vertebrate species.

  20. Hurricane Sandy and earthquakes

    OpenAIRE

    MAVASHEV BORIS; MAVASHEV IGOR

    2013-01-01

    Submit for consideration the connection between formation of a hurricane Sandy and earthquakes. As a rule, weather anomalies precede and accompany earthquakes. The hurricane Sandy emerged 2 days prior to strong earthquakes that occurred in the area. And the trajectory of the hurricane Sandy matched the epicenter of the earthquakes. Possibility of early prediction of natural disasters will minimize the moral and material damage.

  1. John Adams Lecture

    CERN Multimedia

    PH Department

    2010-01-01

    13 December 2010 14:30 - Council Chamber, Bldg.503-1-001 Accelerator Breakthroughs, Achievements and Lessons from the Tevatron Collider V. Shiltsev / Fermilab’s Accelerator Physics Centre This year we celebrate the 25th anniversary of the first proton-antiproton collisions in the Tevatron. For two and a half decades the Tevatron at Fermilab (Batavia, IL, USA) was a centerpiece of the US and world’s High Energy Physics as the world’s highest energy particle collider at 1.8 TeV center of mass energy. While funding agencies are deciding on a 3-year extension of the Collider Run II operation through 2014, we – in this 2010 John Adams Lecture - will take a look in exciting story of the Tevatron: the story of long preparations, great expectations, numerous difficulties, years of “blood and sweat”, continuous upgrades, exceeding original goals (by a factor of 400) and high emotions. An accelerator scientist prospective will be given on a wide spectrum o...

  2. Adam Smith on population.

    Science.gov (United States)

    Spengler, J J

    1970-11-01

    Abstract Adam Smith dealt with questions of population mainly in his Wealth of Nations. His discussion falls roughly under five heads and reflects in considerable measure his image of the English economy. (1) A country's population capacity, given the average level of consumption, was conditioned by the stock of land, the skill with which it was cultivated, and the degree to which division of labour could be increased and thereby augment output for domestic use and sale in external markets. (2) Growth of population was essentially in response to growth of the demand for labour and served to increase division of labour. (3) The social mechanisms underlying elevation of the scale of living are touched upon, and in an optimistic spirit. (4) The distribution of a country's population responded to its progress in opulence, with the rate of this progress conditioned by the degree to which inappropriate (e.g. mercantilist) policies were avoided. (5) Smith dealt briefly with such matters as colonies, education, size of economy, environmental influences, and public policy, all of which he recognized as significant for the quantity and quality of a country's numbers.

  3. Adam Smith and dependency.

    Science.gov (United States)

    Ozler, Sule

    2012-06-01

    The focus of this paper is the works and life of Adam Smith, who is widely recognized as the father and founder of contemporary economics. Latent content analysis is applied to his seminal text in economics, An Inquiry into the Nature and Causes of the Wealth of Nations (1776). The results reveal that Smith considers dependence on others a problem and sees the solution to this problem in impersonalized interdependence. In addition, his views on social dependency and personal dependency, reflected in his Lectures on Jurisprudence (1963) and The Theory of Moral Sentiments (1759), are analyzed. This analysis suggests a central tension between dependence and independence in Smith's writings. The personal dependency patterns he exhibited in his life, which also suggest a tension between dependence and independence, are identified through a reading of his biographies. Based on insights from psychoanalytic literature, this paper proposes that developing the ideas in the Wealth of Nations was part of Smith's creative solution to this tension. In particular, his solution to one individual's dependence on another was through a system of impersonalized interdependence. In other words, Smith defended against his personal dependence through his economic theorizing.

  4. Nonbreaking wave-induced mixing in upper ocean during tropical cyclones using coupled hurricane-ocean-wave modeling

    Science.gov (United States)

    Aijaz, S.; Ghantous, M.; Babanin, A. V.; Ginis, I.; Thomas, B.; Wake, G.

    2017-05-01

    The effects of turbulence generated by nonbreaking waves have been investigated by testing and evaluating a new nonbreaking wave parameterization in a coupled hurricane-ocean-wave model. The MPI version of the Princeton Ocean Model (POM) with hurricane forcing is coupled with the WAVEWATCH-III (WW3) surface wave model. Hurricane Ivan is chosen as the test case due to its extreme intensity and availability of field data during its passage. The model results are validated against field observations of wave heights and sea surface temperatures (SSTs) from the National Data Buoy Centre (NDBC) during Hurricane Ivan and against limited in situ current and bottom temperature data. A series of numerical experiments is set up to examine the influence of the nonbreaking wave parameterization on the mixing of upper ocean. The SST response from the modeling experiments indicates that the nonbreaking wave-induced mixing leads to significant cooling of the SST and deepening of the mixed layer. It was found that the nondimensional constant b1 in the nonbreaking wave parameterization has different impacts on the weak and the strong sides of the storm track. A constant value of b1 leads to improved predictions on the strong side of the storm while a steepness-dependent b1 provides a better agreement with in situ observations on the weak side. A separate simulation of the intense tropical cyclone Olwyn in north-west Australia revealed the same trend for b1 on the strong side of the tropical cyclone.

  5. KGB : de russiske sikkerhedstjenester fra Ivan den Grusomme til Vladimir Putin

    DEFF Research Database (Denmark)

    Kulavig, Erik

    Om den russiske sikkerhedstjeneste eller det hemmelige politis historie fra starten under Ivan den Grusomme i 1600-tallet, gennem tsarernes Rusland og bolsjevikkernes Sovjetunionenen til Putins periode. Med afstikkere til aktiviteterne uden for Ruslands grænser, herunder i Danmark......Om den russiske sikkerhedstjeneste eller det hemmelige politis historie fra starten under Ivan den Grusomme i 1600-tallet, gennem tsarernes Rusland og bolsjevikkernes Sovjetunionenen til Putins periode. Med afstikkere til aktiviteterne uden for Ruslands grænser, herunder i Danmark...

  6. ADAMS executive and operating system

    Science.gov (United States)

    Pittman, W. D.

    1981-01-01

    The ADAMS Executive and Operating System, a multitasking environment under which a variety of data reduction, display and utility programs are executed, a system which provides a high level of isolation between programs allowing them to be developed and modified independently, is described. The Airborne Data Analysis/Monitor System (ADAMS) was developed to provide a real time data monitoring and analysis capability onboard Boeing commercial airplanes during flight testing. It inputs sensor data from an airplane performance data by applying transforms to the collected sensor data, and presents this data to test personnel via various display media. Current utilization and future development are addressed.

  7. What's an Adam's Apple? (For Kids)

    Science.gov (United States)

    ... About Puberty Train Your Temper What's an Adam's Apple? KidsHealth > For Kids > What's an Adam's Apple? Print A A A You're at the ... the throat. This is what's called an Adam's apple. Everyone's larynx grows during puberty, but a girl's ...

  8. Smith, Adam (1723-90)

    DEFF Research Database (Denmark)

    Bouchet, Dominique

    2015-01-01

    Adam Smith is often said to have been the founder of the science of economics and the father of liberalism in the sphere of economics. In fact he was neither. He lived at a turning point in western economic and political history, one that was littered with disruptive developments. He came up with...

  9. THE MOTIF OF THE PRODIGAL SON IN IVAN TURGENEV'S NOVELS

    Directory of Open Access Journals (Sweden)

    Valentina Ivanovna Gabdullina

    2013-11-01

    Full Text Available The author questions the perception of Ivan Turgenev as a “non- Christian writer” and studies the problem of the prodigal son motif functioning in a series of his novels. In his novels, Turgenev pictured different phases of the archetypal story, originating from the Gospel parable of the prodigal son. In the novel Rudin he depicted the phase of spiritual wanderings of the hero who had lost touch with his native land — Russia. In his next novels (Home of the Gentry, Fathers and Sons and Smoke, after leading his hero in circles and sending him back to his paternal home, Turgenev reconstructs the model of human behavior, represented in the parable, thereby recognizing the immutability of the idea formalized in the Gospel. The motif of the return to Russian land gets its completion in Turgenev's last novel Virgin Soil, in which the author paradoxically connects the Westernist idea with the Gospel imperative. Solomin, the son of a deacon, sent by his wise father out to Europe “to get education”, studies in England, masters the European knowledge and returns back “to his native land” to establish his own business in inland Russia. Thus, a series of Turgenev's novels, in which he portrayed different phases of social life, are interlinked with the motif of the prodigal son, who is represented by novels' main characters.

  10. GERMAN EPISTOLARY HERITAGE OF IVAN FRANKO AND ITS DOMINANT FEATURES

    Directory of Open Access Journals (Sweden)

    V.V. Tkachivsky

    2015-09-01

    Full Text Available The epistolary heritage of Ivan Franko contains over six thousand letters. German epistolary correspondence addressed to Vienna, Berlin, Budapest, Heidelberg, Freiburg, Stanislav, Chernivtsi. The author of the article analyzes also the response letters sent to I. Franko. His first letters in German were addressed to Olha Roshkevych. They were written under the strong impression that the epistolary novel “The Sorrows of Young Werther” by J.W. von Goethe had had on I. Franko. The Ukrainian writer’s correspondence with H. Kanner and I. Singer the editors of the weekly newspaper “Zeit” is an evidence of their close cooperation. I. Franko had close professional ties with V. Adler one of the founders and leaders of the Austrian social-democratic party, the editor of Vienna newspaper “Arbeiterzeitung”, as well as with V. Adler’s wife Emma. I. Franko’s correspondence with a prominent Slavic scholar V. Yagic didn’t contain only private matters discussions. The third part of it is totally scientific which actually makes it valuable for researchers. I. Franko’s epistolary works reflect his artistic writer’s style neither in form nor in content. His letters are characterized by the depth of his thought, consistency of his statements, clearness of the sentence constructions, tendency to critical assessments of phenomena and scientific findings.

  11. ADAM33 and ADAM12 genetic polymorphisms and their expression in Egyptian children with asthma.

    Science.gov (United States)

    Shalaby, Sally M; Abdul-Maksoud, Rehab S; Abdelsalam, Sanaa M; Abdelrahman, Hadeel M; Abdelaziz Almalky, Mohamed A

    2016-01-01

    The ADAM family is involved in some pathologic processes, such as inflammation and asthma. To assess the association between ADAM33 and ADAM12 single-nucleotide polymorphisms (SNPs) with asthma risk and severity and to investigate the effect of ADAM33 and ADAM12 polymorphisms on expression of these proteases in sputum. Two SNPs of the ADAM33 gene, F+1 (rs511898) G/A and ST+4 (rs44707) A/C, and 2 SNPs of the ADAM12 gene, rs3740199 and rs1871054, were analyzed in 400 asthma cases and 200 controls aged 3 to 14 years using the polymerase chain reaction-restriction fragment length polymorphism method. Messenger RNA expression profile of ADAM33 and ADAM12 proteases in sputum from studied groups was determined by reverse transcription polymerase chain reaction. ADAM33 F+1 homozygous mutant genotype (AA) and ST+4 heterozygous and homozygous mutant genotype (AC and CC) and mutant alleles of both polymorphisms were significantly associated with asthma risk and severity in moderate and severe subgroups. Patients with the ADAM12 (rs3740199) CC genotype were at increased risk for moderate and severe asthma. Messenger RNA levels of ADAM12 were significantly increased in asthmatic children compared with controls, whereas we were not able to detect the expression of ADAM33 in the sputum of the groups studied. The ADAM12 expression was significantly higher in homozygous CC (variant type) compared with homozygous GG (wild type) of both ADAM12 rs3740199 and rs1871054 in the asthmatic group. Our analysis suggests a likely role for ADAM33 and ADAM12 in the development of asthma in Egyptian children. Furthermore, ADAM12 polymorphisms may affect ADAM12 expression in asthma. Copyright © 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  12. Recovering from Hurricane Katrina

    Science.gov (United States)

    Coleman, Nadine

    2006-01-01

    The Gulf Coast region suffered an unusually severe hurricane season in 2005: Hurricane Katrina (August 28-29, 2005) devastated much of southern Mississippi and Louisiana. Approximately 2,700 licensed early care and education facilities in those states and in Alabama were affected by Katrina, in addition to an unknown number of family child care…

  13. Hurricanes and coral bleaching linked to changes in coral recruitment in Tobago.

    Science.gov (United States)

    Mallela, J; Crabbe, M J C

    2009-10-01

    Knowledge of coral recruitment patterns helps us understand how reefs react following major disturbances and provides us with an early warning system for predicting future reef health problems. We have reconstructed and interpreted historical and modern-day recruitment patterns, using a combination of growth modelling and in situ recruitment experiments, in order to understand how hurricanes, storms and bleaching events have influenced coral recruitment on the Caribbean coastline of Tobago. Whilst Tobago does not lie within the main hurricane belt results indicate that regional hurricane events negatively impact coral recruitment patterns in the Southern Caribbean. In years following hurricanes, tropical storms and bleaching events, coral recruitment was reduced when compared to normal years (p=0.016). Following Hurricane Ivan in 2004 and the 2005-2006 bleaching event, coral recruitment was markedly limited with only 2% (n=6) of colonies estimated to have recruited during 2006 and 2007. Our experimental results indicate that despite multiple large-scale disturbances corals are still recruiting on Tobago's marginal reef systems, albeit in low numbers.

  14. Geologic effects of hurricanes

    Science.gov (United States)

    Coch, Nicholas K.

    1994-08-01

    Hurricanes are intense low pressure systems of tropical origin. Hurricane damage results from storm surge, wind, and inland flooding from heavy rainfall. Field observations and remote sensing of recent major hurricanes such as Hugo (1989), Andrew (1992) and Iniki (1992) are providing new insights into the mechanisms producing damage in these major storms. Velocities associated with hurricanes include the counterclockwise vortex winds flowing around the eye and the much slower regional winds that steer hurricane and move it forward. Vectorial addition of theseof these two winds on the higher effective wind speed than on the left side. Coast-parallel hurricane tracks keep the weaker left side of the storm against the coast, whereas coast-normal tracks produce a wide swath of destruction as the more powerful right side of the storm cuts a swath of destruction hundreds of kilometers inland. Storm surge is a function of the wind speed, central pressure, shelf slope, shoreline configuration, and anthropogenic alterations to the shoreline. Maximum surge heights are not under the eye of the hurricane, where the pressure is lowest, but on the right side of the eye at the radius of maximum winds, where the winds are strongest. Flood surge occurs as the hurricane approaches land and drives coastal waters, and superimposed waves, across the shore. Ebb surge occurs when impounded surface water flows seaward as the storm moves inland. Flood and ebb surge damage have been greatly increased in recent hurricanes as a result of anthropogenic changes along the shoreline. Hurricane wind damage occurs on three scales — megascale, mesoscale and microscale. Local wind damage is a function of wind speed, exposure and structural resistance to velocity pressure, wind drag and flying debris. Localized extreme damage is caused by gusts that can locally exceed sustained winds by a factor of two in areas where there is strong convective activity. Geologic changes occuring in hurricanes

  15. Data and numerical analysis of astronomic tides, wind-waves, and hurricane storm surge along the northern Gulf of Mexico

    Science.gov (United States)

    Bilskie, M. V.; Hagen, S. C.; Medeiros, S. C.; Cox, A. T.; Salisbury, M.; Coggin, D.

    2016-05-01

    The northern Gulf of Mexico (NGOM) is a unique geophysical setting for complex tropical storm-induced hydrodynamic processes that occur across a variety of spatial and temporal scales. Each hurricane includes its own distinctive characteristics and can cause unique and devastating storm surge when it strikes within the intricate geometric setting of the NGOM. While a number of studies have explored hurricane storm surge in the NGOM, few have attempted to describe storm surge and coastal inundation using observed data in conjunction with a single large-domain high-resolution numerical model. To better understand the oceanic and nearshore response to these tropical cyclones, we provide a detailed assessment, based on field measurements and numerical simulation, of the evolution of wind waves, water levels, and currents for Hurricanes Ivan (2004), Dennis (2005), Katrina (2005), and Isaac (2012), with focus on Mississippi, Alabama, and the Florida Panhandle coasts. The developed NGOM3 computational model describes the hydraulic connectivity among the various inlet and bay systems, Gulf Intracoastal Waterway, coastal rivers and adjacent marsh, and built infrastructure along the coastal floodplain. The outcome is a better understanding of the storm surge generating mechanisms and interactions among hurricane characteristics and the NGOM's geophysical configuration. The numerical analysis and observed data explain the ˜2 m/s hurricane-induced geostrophic currents across the continental shelf, a 6 m/s outflow current during Ivan, the hurricane-induced coastal Kelvin wave along the shelf, and for the first time a wealth of measured data and a detailed numerical simulation was performed and was presented for Isaac.

  16. Photography travel journal of Belgrade by Ivan Groman a different view of the photographic work of Ivan Groman

    Directory of Open Access Journals (Sweden)

    Radoš Aleksandar

    2002-01-01

    Full Text Available Little is known about a Russian photographer, Ivan Groman. His photographic work, originating in 1876 in the Principality of Serbia, was used repeatedly for illustrations, but has never been thoroughly analyzed as a historic document. Although his photographs, kept in the Archives of the City of Belgrade, the Museum of the City of Belgrade, and the Military Museum in Belgrade, may not represent his entire photographic opus, a thorough analysis of his work may serve the purpose of seeking for the message, and therefore for the aim of his work and stay in Belgrade. A small number of his photographs of Belgrade, constituting small series (‘stories’ of a relatively small area, clearly lead to the conclusion that I. V. Groman was not just a photographer – documentarist with an unquestionable and subtle artistic sense, but also a perceptive and possibly experienced “documentarist on a military mission”. It does not diminish the significance and value of his photographic work in Belgrade. Quite the opposite. His opus gains the documentary vigor of the travel journal photo-story, which in its expressiveness does not fall short of the travel journals of a more traditional kind.

  17. Adams operators and knot decorations

    CERN Document Server

    Aiston, A K

    1997-01-01

    We use an explicit isomorphism from the representation ring of the quantum group U_q(sl(N)) to the Homfly skein of the annulus, to determine an element of the skein which is the image of the mth Adams operator, \\psi_m, on the fundamental representation, c_1. This element is a linear combination of m very simple m-string braids. Using this skein element, we show that the Vassiliev invariant of degree n in the power series expansion of the U_q(sl(N)) quantum invariant of a knot coloured by \\psi_m(c_1) is the canonical Vassiliev invariant with weight system W_n\\psi_m^{(n)} where W_n is the weight system for the Vassiliev invariant of degree n in the expansion of the quantum invariant of the knot coloured by c_1 and \\psi_m^{(n)} is the Adams operator on n-chord diagrams defined by Bar-Natan.

  18. A Conversation with Adam Heller

    OpenAIRE

    Heller, A.; Cairns, EJ

    2015-01-01

    © 2015 by Annual Reviews. All rights reserved.Adam Heller, Ernest Cockrell Sr. Chair in Engineering Emeritus of the John J. McKetta Department of Chemical Engineering at The University of Texas at Austin, recalls his childhood in the Holocaust and his contributions to science and technology that earned him the US National Medal of Technology and Innovation in a conversation with Elton J. Cairns, Professor of Chemical and Biomolecular Engineering at the University of California, Berkeley. Dr. ...

  19. Hurricane Imaging Radiometer

    Science.gov (United States)

    Cecil, Daniel J.; Biswas, Sayak K.; James, Mark W.; Roberts, J. Brent; Jones, W. Linwood; Johnson, James; Farrar, Spencer; Sahawneh, Saleem; Ruf, Christopher S.; Morris, Mary; hide

    2014-01-01

    The Hurricane Imaging Radiometer (HIRAD) is a synthetic thinned array passive microwave radiometer designed to allow retrieval of surface wind speed in hurricanes, up through category five intensity. The retrieval technology follows the Stepped Frequency Microwave Radiometer (SFMR), which measures surface wind speed in hurricanes along a narrow strip beneath the aircraft. HIRAD maps wind speeds in a swath below the aircraft, about 50-60 km wide when flown in the lower stratosphere. HIRAD has flown in the NASA Genesis and Rapid Intensification Processes (GRIP) experiment in 2010 on a WB-57 aircraft, and on a Global Hawk unmanned aircraft system (UAS) in 2012 and 2013 as part of NASA's Hurricane and Severe Storms Sentinel (HS3) program. The GRIP program included flights over Hurricanes Earl and Karl (2010). The 2012 HS3 deployment did not include any hurricane flights for the UAS carrying HIRAD. The 2013 HS3 flights included one flight over the predecessor to TS Gabrielle, and one flight over Hurricane Ingrid. This presentation will describe the HIRAD instrument, its results from the 2010 and 2013 flights, and potential future developments.

  20. Hurricane! Coping With Disaster

    Science.gov (United States)

    Lifland, Jonathan

    A new AGU book, Hurricane! Coping With Disaster, analyzes the progress made in hurricane science and recounts how advances in the field have affected the public's and the scientific community's understanding of these storms. The book explores the evolution of hurricane study, from the catastrophic strike in Galveston, Texas in 1900—still the worst natural disaster in United States history—to today's satellite and aircraft observations that track a storm's progress and monitor its strength. In this issue, Eos talks with Robert Simpson, the books' senior editor.Simpson has studied severe storms for more than 60 years, including conducting one of the first research flights through a hurricane in 1945. He was the founding director of the (U.S.) National Hurricane Research Project and has served as director of the National Hurricane Center. In collaboration with Herbert Saffir, Simpson helped design and implement the Saffir/Simpson damage potential scale that is widely used to identify potential damage from hurricanes.

  1. Comment peut-on lire Ivan Hadjiiski aujourd’hui ?

    Directory of Open Access Journals (Sweden)

    Svetla Koleva

    2010-06-01

    Full Text Available Présentation de deux textes d’Ivan Hadjiiski (1907-1944 : « Les racines historiques de nos traditions démocratiques » paru pour la première fois dans la Revue Philosophique/Filossofski pregled, 1937, 9/1 ; et « Traits atypiques du développement de notre société », paru dans Problèmes sociologiques/Sotziologitcheski problemi, 1986, n° 3, et publiés ici avec l’autorisation des tenants des droits d’auteur.How to read Ivan Hadjiiski today? Introduction to two Ivan Hajiisji’s textsPresentation of Ivan Hadjiiski’s two texts:"Historical roots of our democratic traditions", first published in Philosophical Journal/Filossofski pregled, 1937, 9/1, and "Atypical features of our society’s development" first published in Sociological Problems/Sotziologitcheski problemi, 1986, n° 3, which are published here with the kind authorization of copyright owners.¿Como se puede leer hoy Ivan Hadjiiski?Introducción y análisis de dos textos de Ivan Hadjiiski: "Las raíces históricas de nuestras tradiciones democráticas", publicado por primera vez en EstudioFilosófico/Filossofski pregled, 1937, 9/1, y "Aspectos inhabituales del desarrollo de la sociedad actual" publicado por primera vez en Problemas sociológicos/Sotziologitcheski problemi, 1986, n° 3, y aquí publicados con la amable autorización de los teniendos de los derechos de autor.

  2. Analyzing Hurricane Sandy

    Science.gov (United States)

    Convertino, Angelyn; Meyer, Stephan; Edwards, Becca

    2015-03-01

    Post-tropical Storm Sandy underwent extratropical transition shortly before making landfall in southern New Jersey October 29 2012. Data from this system was compared with data from Hurricane Ike (2008) which represents a classic hurricane with a clear eye wall and symmetry after landfall. Storm Sandy collided with a low pressure system coming in from the north as the hurricane made landfall on the US East coast. This contributed to Storm Sandy acting as a non-typical hurricane when it made landfall. Time histories of wind speed and wind direction were generated from data provided by Texas Tech's StickNet probes for both storms. The NOAA Weather and Climate program were used to generate radar loops of reflectivity during the landfall for both storms; these loops were compared with time histories for both Ike and Sandy to identify a relationship between time series data and storm-scale features identified on radar.

  3. Cooperative Hurricane Network Obs

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Observations from the Cooperative Hurricane Reporting Network (CHURN), a special network of stations that provided observations when tropical cyclones approached the...

  4. Hurricane Katrina disaster diplomacy.

    Science.gov (United States)

    Kelman, Ilan

    2007-09-01

    Hurricane Katrina struck the United States at the end of August 2005. The consequent devastation appeared to be beyond the US government's ability to cope with and aid was offered by several states in varying degrees of conflict with the US. Hurricane Katrina therefore became a potential case study for 'disaster diplomacy', which examines how disaster-related activities do and do not yield diplomatic gains. A review of past disaster diplomacy work is provided. The literature's case studies are then categorised using a new typology: propinquity, aid relationship, level and purpose. Hurricane Katrina and its aftermath are then placed in the context of the US government's foreign policy, the international response to the disaster and the US government's reaction to these responses. The evidence presented is used to discuss the potential implications of Hurricane Katrina disaster diplomacy, indicating that factors other than disaster-related activities generally dominate diplomatic relations and foreign policy.

  5. Hurricane Matthew overwash extents

    Science.gov (United States)

    Doran, Kara; Long, Joseph W.; Birchler, Justin; Range, Ginger

    2017-01-01

    The National Assessment of Coastal Change Hazards project exists to understand and predict storm impacts to our nation's coastlines. This data defines the alongshore extent of overwash deposits attributed to coastal processes during Hurricane Matthew.

  6. Hurricane Katrina Water Sampling

    Science.gov (United States)

    Hurricane Katrina made landfall in August 2005, causing widespread devastation along the Gulf Coast of the United States. EPA emergency response personnel worked with FEMA and state and local agencies to respond to the emergencies throughout the Gulf.

  7. Hurricane Katrina Sediment Sampling

    Science.gov (United States)

    Hurricane Katrina made landfall in August 2005, causing widespread devastation along the Gulf Coast of the United States. EPA emergency response personnel worked with FEMA and state and local agencies to respond to the emergencies throughout the Gulf.

  8. Hurricane Katrina Soil Sampling

    Science.gov (United States)

    Hurricane Katrina made landfall in August 2005, causing widespread devastation along the Gulf Coast of the United States. EPA emergency response personnel worked with FEMA and state and local agencies to respond to the emergencies throughout the Gulf.

  9. Hurricane Katrina Water Sampling

    Data.gov (United States)

    U.S. Environmental Protection Agency — Hurricane Katrina made landfall in August 2005, causing widespread devastation along the Gulf Coast of the United States. EPA emergency response personnel worked...

  10. Hurricane Katrina Soil Sampling

    Data.gov (United States)

    U.S. Environmental Protection Agency — Hurricane Katrina made landfall in August 2005, causing widespread devastation along the Gulf Coast of the United States. EPA emergency response personnel worked...

  11. Hurricane Katrina Sediment Sampling

    Data.gov (United States)

    U.S. Environmental Protection Agency — Hurricane Katrina made landfall in August 2005, causing widespread devastation along the Gulf Coast of the United States. EPA emergency response personnel worked...

  12. Probabilistic prediction of barrier-island response to hurricanes

    Science.gov (United States)

    Plant, Nathaniel G.; Stockdon, Hilary F.

    2012-01-01

    Prediction of barrier-island response to hurricane attack is important for assessing the vulnerability of communities, infrastructure, habitat, and recreational assets to the impacts of storm surge, waves, and erosion. We have demonstrated that a conceptual model intended to make qualitative predictions of the type of beach response to storms (e.g., beach erosion, dune erosion, dune overwash, inundation) can be reformulated in a Bayesian network to make quantitative predictions of the morphologic response. In an application of this approach at Santa Rosa Island, FL, predicted dune-crest elevation changes in response to Hurricane Ivan explained about 20% to 30% of the observed variance. An extended Bayesian network based on the original conceptual model, which included dune elevations, storm surge, and swash, but with the addition of beach and dune widths as input variables, showed improved skill compared to the original model, explaining 70% of dune elevation change variance and about 60% of dune and shoreline position change variance. This probabilistic approach accurately represented prediction uncertainty (measured with the log likelihood ratio), and it outperformed the baseline prediction (i.e., the prior distribution based on the observations). Finally, sensitivity studies demonstrated that degrading the resolution of the Bayesian network or removing data from the calibration process reduced the skill of the predictions by 30% to 40%. The reduction in skill did not change conclusions regarding the relative importance of the input variables, and the extended model's skill always outperformed the original model.

  13. Comparison and validation of statistical methods for predicting power outage durations in the event of hurricanes.

    Science.gov (United States)

    Nateghi, Roshanak; Guikema, Seth D; Quiring, Steven M

    2011-12-01

    This article compares statistical methods for modeling power outage durations during hurricanes and examines the predictive accuracy of these methods. Being able to make accurate predictions of power outage durations is valuable because the information can be used by utility companies to plan their restoration efforts more efficiently. This information can also help inform customers and public agencies of the expected outage times, enabling better collective response planning, and coordination of restoration efforts for other critical infrastructures that depend on electricity. In the long run, outage duration estimates for future storm scenarios may help utilities and public agencies better allocate risk management resources to balance the disruption from hurricanes with the cost of hardening power systems. We compare the out-of-sample predictive accuracy of five distinct statistical models for estimating power outage duration times caused by Hurricane Ivan in 2004. The methods compared include both regression models (accelerated failure time (AFT) and Cox proportional hazard models (Cox PH)) and data mining techniques (regression trees, Bayesian additive regression trees (BART), and multivariate additive regression splines). We then validate our models against two other hurricanes. Our results indicate that BART yields the best prediction accuracy and that it is possible to predict outage durations with reasonable accuracy. © 2011 Society for Risk Analysis.

  14. ADAMs family and relatives in cardiovascular physiology and pathology.

    Science.gov (United States)

    Zhang, Pu; Shen, Mengcheng; Fernandez-Patron, Carlos; Kassiri, Zamaneh

    2016-04-01

    A disintegrin and metalloproteinases (ADAMs) are a family of membrane-bound proteases. ADAM-TSs (ADAMs with thrombospondin domains) are a close relative of ADAMs that are present in soluble form in the extracellular space. Dysregulated production or function of these enzymes has been associated with pathologies such as cancer, asthma, Alzheimer's and cardiovascular diseases. ADAMs contribute to angiogenesis, hypertrophy and apoptosis in a stimulus- and cell type-dependent manner. Among the ADAMs identified so far (34 in mouse, 21 in human), ADAMs 8, 9, 10, 12, 17 and 19 have been shown to be involved in cardiovascular development or cardiomyopathies; and among the 19 ADAM-TSs, ADAM-TS1, 5, 7 and 9 are important in development of the cardiovascular system, while ADAM-TS13 can contribute to vascular disorders. Meanwhile, there remain a number of ADAMs and ADAM-TSs whose function in the cardiovascular system has not been yet explored. The current knowledge about the role of ADAMs and ADAM-TSs in the cardiovascular pathologies is still quite limited. The most detailed studies have been performed in other cell types (e.g. cancer cells) and organs (nervous system) which can provide valuable insight into the potential functions of ADAMs and ADAM-TSs, their mechanism of action and therapeutic potentials in cardiomyopathies. Here, we review what is currently known about the structure and function of ADAMs and ADAM-TSs, and their roles in development, physiology and pathology of the cardiovascular system.

  15. Continental United States Hurricane Strikes

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Continental U.S. Hurricane Strikes Poster is our most popular poster which is updated annually. The poster includes all hurricanes that affected the U.S. since...

  16. Hurricane Katrina: A Teachable Moment

    Science.gov (United States)

    Bertrand, Peggy

    2009-01-01

    This article presents suggestions for integrating the phenomenon of hurricanes into the teaching of high school fluid mechanics. Students come to understand core science concepts in the context of their impact upon both the environment and human populations. Suggestions for using information about hurricanes, particularly Hurricane Katrina, in a…

  17. Hurricane Katrina: A Teachable Moment

    Science.gov (United States)

    Bertrand, Peggy

    2009-01-01

    This article presents suggestions for integrating the phenomenon of hurricanes into the teaching of high school fluid mechanics. Students come to understand core science concepts in the context of their impact upon both the environment and human populations. Suggestions for using information about hurricanes, particularly Hurricane Katrina, in a…

  18. 2004 Post-Hurricane Ivan Northern Gulf of Mexico EAARL Lidar-Derived Dune Crest, Toe and Shoreline

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Storm-Induced Coastal Change Hazards component of the National Assessment of Coastal Change Hazards project focuses on understanding the magnitude and...

  19. Upper-Ocean Response to Hurricane Ivan in a 1/25 degree Nested Gulf of Mexico HYCOM

    Science.gov (United States)

    2007-04-18

    the assimilation run [Browning and Kreiss, 1982, 1986] is used for the baro - agrees with the observations while the northern edge of LC tropic open...difference (see Kara et al. layers [ Martin , 1985] (2) the number of adjustable para- [2002] for details). Briefly, latent heat flux (QL) and sensible...202. computer time from the DoD High Performance Computer Modernization Martin , P. J. (1985), Simulation of the mixed layer at OWS November and Papa

  20. 2004 US Army Corps of Engineers (USACE) Post-Hurricane Ivan Topo/Bathy Lidar: Alabama, Florida

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data were collected by the Joint Airborne Lidar Bathymetry Technical Center of Expertise using the CHARTS system. The data includes hydrographic and...

  1. Impact of Hurricane Ivan on the regional longleaf pine growth study: is there a relation to site or stand conditions?

    Science.gov (United States)

    John S. Kush; John C. Gilbert

    2010-01-01

    The US Forest Service Regional Longleaf Pine Growth Study (RLGS) began its eighth re-measurement (40th year) during 2004 autumn. The study has 305 plots of which 171 plots are located on the Escambia Experimental Forest (EEF) in Brewton AL. EEF is operated by the U.S. Forest Service in cooperation with the T.R. Miller Mill Company. The RLGS has plots distributed across...

  2. 2004 USGS/NASA Experimental Advanced Airborne Research Lidar (EAARL): Northern Gulf of Mexico, Post-Hurricane Ivan

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — ASCII xyz point cloud data were produced from remotely-sensed, geographically-referenced elevation measurements in cooperation with the U.S. Geological Survey (USGS)...

  3. Social and psychological resources associated with health status in a representative sample of adults affected by the 2004 Florida hurricanes.

    Science.gov (United States)

    Ruggiero, Kenneth J; Amstadter, Ananda B; Acierno, Ron; Kilpatrick, Dean G; Resnick, Heidi S; Tracy, Melissa; Galea, Sandro

    2009-01-01

    Overall health status after a disaster may be associated with long-term physical morbidity and mortality. Little is known about factors associated with overall health status in the aftermath of disasters. We examined self-rated health in relation to disaster characteristics, social resources, and post-disaster outcomes in a sample of adults who experienced the 2004 Florida hurricanes. We interviewed a representative sample of 1,452 adults aged 18 years and older residing in the 33 Florida counties that were in the direct path of at least one of the 2004 hurricanes (Charley, Frances, Ivan, Jeanne). Overall health status was assessed using a self-rating format known to be predictive of mortality. Poor self-rated health was endorsed by 14.6% of the sample. Final multivariable models showed that poor self-rated health was associated with older age (p hurricane (p = 0.03), low social support (p = 0.03), and depression (p = 0.003) since the hurricane. Self-rated health following the Florida hurricanes was strongly associated with two variables (social support and depression) that potentially can be mitigated through targeted interventions after disasters. Future work should evaluate secondary prevention strategies that can address general health-related concerns in the wake of a disaster.

  4. Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis.

    Science.gov (United States)

    Li, Qing; Xie, Jing; He, Lin; Wang, Yuanli; Duan, Zelin; Yang, Hongdan; Wang, Qun

    2015-05-10

    The ADAM (a disintegrin and metalloprotease) family plays an important role in sperm and egg fusion, development, inflammation, adhesion and migration. ADAM10 and ADAM17 are involved in the spermatogenesis. To better understand the role of ADAM10 and ADAM17 in the Chinese mitten crab, Eriocheir sinensis, the full-length cDNAs of ADAM10 and ADAM17 were cloned, and named Es-ADAM10 and Es-ADAM17, respectively. Sequence and structural analysis showed that Es-ADAM10 and Es-ADAM17 have the typical structure of the ADAM family. Quantitative real-time reverse transcription polymerase chain reaction analysis showed that Es-ADAM10 and Es-ADAM17 mRNAs were distributed in the heart, hepatopancreas, intestines, brain, muscle, thoracic ganglia, hemolymph, stomach, testis, ovary, gill and accessory gland. Both mRNAs were highly expressed in the muscles, and relatively high in the testis, ovary and accessory gland. In addition, the Es-ADAM17 mRNA level was detected in every stage of testis development, being relatively high from July to September, the lowest during October and November, increasing from December to January, and reached a peak in January. By contrast, the expression of Es-ADAM10 mRNA was constant during testis development. Immunofluorescence further showed that Es-ADAM10 and Es-ADAM17 proteins were present in the cytoplasm and cytomembrane of spermatocytes, and both detected in the sperm. Furthermore, etoposide induced upregulation of Es-ADAM17 and Es-ADAM10 at both the mRNA and protein levels. This study first showed that Es-ADAM10 and Es-ADAM17 were also involved in the spermatogenesis and mainly participated in the later germ cell apoptosis in E. sinensis.

  5. Activation of ADAM 12 protease by copper

    DEFF Research Database (Denmark)

    Loechel, F; Wewer, Ulla M.

    2001-01-01

    Conversion of latent proteases to the active form occurs by various mechanisms characteristic for different protease families. Here we report that the disintegrin metalloprotease ADAM 12-S is activated by Cu(II). Copper activation is distinct from the cysteine switch component of latency......: elimination of the ADAM 12 cysteine switch by a point mutation in the propeptide had no effect on copper activation, whereas mutation of an unpaired cysteine residue in the catalytic domain resulted in a mutant form of ADAM 12-S that was insensitive to copper. This suggests a multi-step activation mechanism...

  6. ADAM: Analyzer for Dialectal Arabic Morphology

    Directory of Open Access Journals (Sweden)

    Wael Salloum

    2014-12-01

    Full Text Available While Modern Standard Arabic (MSA has many resources, Arabic Dialects, the primarily spoken local varieties of Arabic, are quite impoverished in this regard. In this article, we present ADAM (Analyzer for Dialectal Arabic Morphology. ADAM is a poor man’s solution to quickly develop morphological analyzers for dialectal Arabic. ADAM has roughly half the out-of-vocabulary rate of a state-of-the-art MSA analyzer and is comparable in its recall performance to an Egyptian dialectal morphological analyzer that took years and expensive resources to build.

  7. Adam Smith’s contribution to secularisation

    Directory of Open Access Journals (Sweden)

    Petrus Simons

    2013-06-01

    Full Text Available This article examined several crucial themes in Adam Smith’s philosophy with the purpose of highlighting and assessing his contribution to the secularisation of Western society. The article, written from the perspective of reformational philosophy, begins with a brief biography and sketch of Adam Smith’s influence on modern society, followed by a summary of Ponti Venter’s view on Smith. This sets the scene for a discussion of Adam Smith’s project, his method of tackling it, and his views on systems, philosophy of history and the concept of philosophy.

  8. ADAM9 Is a Novel Product of Polymorphonuclear Neutrophils

    DEFF Research Database (Denmark)

    Roychaudhuri, Robin; Hergrueter, Anja H; Polverino, Francesca

    2014-01-01

    A disintegrin and a metalloproteinase domain (ADAM) 9 is known to be expressed by monocytes and macrophages. In this study, we report that ADAM9 is also a product of human and murine polymorphonuclear neutrophils (PMNs). ADAM9 is not synthesized de novo by circulating PMNs. Rather, ADAM9 protein ...

  9. Järjest rohkem venelasi saab aru, et neid on petetud / Ivan Tšumakov ; intervjueerinud Taavi Minnik

    Index Scriptorium Estoniae

    Tšumakov, Ivan

    2016-01-01

    Intervjuu Venemaa ökonomisti ja poliitikaanalüütiku Ivan Tšumakoviga Venemaa majanduslikest perspektiividest ja sellest, mida võimude poliitika on Venemaa tavakodanikele viimastel aastatel kaasa toonud

  10. Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space.

    Science.gov (United States)

    Pruessmeyer, Jessica; Hess, Franz Martin; Alert, Henriette; Groth, Esther; Pasqualon, Tobias; Schwarz, Nicole; Nyamoya, Stella; Kollert, Jos; van der Vorst, Emiel; Donners, Marjo; Martin, Christian; Uhlig, Stefan; Saftig, Paul; Dreymueller, Daniela; Ludwig, Andreas

    2014-06-26

    Inflammation is a key process in various diseases, characterized by leukocyte recruitment to the inflammatory site. This study investigates the role of a disintegrin and a metalloproteinase (ADAM) 10 and ADAM17 for leukocyte migration in vitro and in a murine model of acute pulmonary inflammation. Inhibition experiments or RNA knockdown indicated that monocytic THP-1 cells and primary human neutrophils require ADAM10 but not ADAM17 for efficient chemokine-induced cell migration. Signaling and adhesion events that are linked to cell migration such as p38 and ρ GTPase-family activation, F-actin polymerization, adhesion to fibronectin, and up-regulation of α5 integrin were also dependent on ADAM10 but not ADAM17. This was confirmed with leukocytes isolated from mice lacking either ADAM10 or ADAM17 in all hematopoietic cells (vav 1 guanine nucleotide exchange factor [Vav]-Adam10(-/-) or Vav-Adam17(-/-) mice). In lipopolysaccharide-induced acute pulmonary inflammation, alveolar recruitment of neutrophils and monocytes was transiently increased in Vav-Adam17(-/-) but steadily reduced in Vav-Adam10(-/-) mice. This deficit in alveolar leukocyte recruitment was also observed in LysM-Adam10(-/-) mice lacking ADAM10 in myeloid cells and correlated with protection against edema formation. Thus, with regard to leukocyte migration, leukocyte-expressed ADAM10 but not ADAM17 displays proinflammatory activities and may therefore serve as a target to limit inflammatory cell recruitment.

  11. the Cecil John Adams Travelling Fellowship

    African Journals Online (AJOL)

    1994-09-14

    Sep 14, 1994 ... founded the Cecil John Adams Travelling Fellowship Trust in 1945. (photograph taken .... awards have been made to 137 people. ... Dr Alexander (Sandy) A. Brown. He and Dr T. .... think of a suitable means of achieving this.

  12. Kellwood Company Finalizes Acquisition of ADAM

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The Town and Country-based apparel company Kellwood Company announced its acquisition of ADAM according to Michael Kramer,Chief Executive Officer and President of Kellwood.This acquisition is the first in

  13. Mons. Ivan Trinko (1863-1954. Promotore della conoscenza e del dialogo tra le culture.

    Directory of Open Access Journals (Sweden)

    Mitja Skubic

    2007-12-01

    Full Text Available La miscellanea sulla quale vogliamo brevemente attirare l'attenzione dei colleghi linguisti rappresenta in sostanza gli Atti del Convegno svoltosi a Špeter/San Pietro al Natisone nel 2004 in occasione del cinquantesimo anniversario della morte di Ivan Trinko, redatti da Roberto Dapit, Michele Obit e Lucia Trusgnach. Non solo nel titolo, il bilinguismo sloveno-italiano è rispettato nella stesura di tutti i testi, uno tra di loro appare addirittura in veste trilingue, slovena, italiana e friulana.

  14. Ivan Franko's novel Dlja domashnjoho ohnyshcha (For the Hearth) in the light of the frequency dictionary

    CERN Document Server

    Buk, Solomiya

    2010-01-01

    In the article, the methodology and the principles of the compilation of the Frequency dictionary for Ivan Franko's novel Dlja domashnjoho ohnyshcha (For the Hearth) are described. The following statistical parameters of the novel vocabulary are obtained: variety, exclusiveness, concentration indexes, correlation between word rank and text coverage, etc. The main quantitative characteristics of Franko's novels Perekhresni stezhky (The Cross-Paths) and Dlja domashnjoho ohnyshcha are compared on the basis of their frequency dictionaries.

  15. National assessment of hurricane-induced coastal erosion hazards: Southeast Atlantic Coast

    Science.gov (United States)

    Stockdon, Hilary F.; Doran, Kara S.; Thompson, David M.; Sopkin, Kristin L.; Plant, Nathaniel G.

    2013-01-01

    Beaches serve as a natural barrier between the ocean and inland communities, ecosystems, and natural resources. However, these dynamic environments move and change in response to winds, waves, and currents. During extreme storms, changes to beaches can be large, and the results are sometimes catastrophic. Lives may be lost, communities destroyed, and millions of dollars spent on rebuilding. During storms, large waves may erode beaches, and high storm surge shifts the erosive force of the waves higher on the beach. In some cases, the combined effects of waves and surge may cause overwash or flooding. Building and infrastructure on or near a dune can be undermined during wave attack and subsequent erosion. During Hurricane Ivan in 2004, a five-story condominium in Orange Beach, Alabama, collapsed after the sand dune supporting the foundation eroded. The September 1999 landfall of Hurricane Dennis caused erosion and undermining that destroyed roads, foundations, and septic systems. Waves overtopping a dune can transport sand inland, covering roads and blocking evacuation routes or emergency relief. If storm surge inundates barrier island dunes, currents flowing across the island can create a breach, or new inlet, completely severing evacuation routes. Waves and surge during the 2003 landfall of Hurricane Isabel left a 200-meter (m) wide breach that cut the only road to and from the village of Hatteras, N.C. Extreme coastal changes caused by hurricanes may increase the vulnerability of communities both during a storm and to future storms. For example, when sand dunes on a barrier island are eroded substantially, inland structures are exposed to storm surge and waves. Absent or low dunes also allow water to flow inland across the island, potentially increasing storm surge in the back bay, on the soundside of the barrier, and on the mainland. During Hurricane Isabel the protective sand dunes near the breach were completely eroded, increasing vulnerability to future

  16. Airborne laser quantification of Florida shoreline and beach volume change caused by hurricanes

    Science.gov (United States)

    Robertson, William, V.

    This dissertation combines three separate studies that measure coastal change using airborne laser data. The initial study develops a method for measuring subaerial and subaqueous volume change incrementally alongshore, and compares those measurements to shoreline change in order to quantify their relationship in Palm Beach County, Florida. A poor correlation (R2 = 0.39) was found between shoreline and volume change before the hurricane season in the northern section of Palm Beach County because of beach nourishment and inlet dynamics. However, a relatively high R2 value of 0.78 in the southern section of Palm Beach County was found due to little disturbance from tidal inlets and coastal engineering projects. The shoreline and volume change caused by the 2004 hurricane season was poorly correlated with R 2 values of 0.02 and 0.42 for the north and south sections, respectively. The second study uses airborne laser data to investigate if there is a significant relationship between shoreline migration before and after Hurricane Ivan near Panama City, Florida. In addition, the relationship between shoreline change and subaerial volume was quantified and a new method for quantifying subaqueous sediment change was developed. No significant spatial relationship was found between shoreline migration before and after the hurricane. Utilization of a single coefficient to represent all relationships between shoreline and subaerial volume change was found to be problematic due to the spatial variability in the linear relationship. Differences in bathymetric data show only a small portion of sediment was transported beyond the active zone and most sediment remained within the active zone despite the occurrence of a hurricane. The third study uses airborne laser bathymetry to measure the offshore limit of change, and compares that location with calculated depth of closures and subaqueous geomorphology. There appears to be strong geologic control of the depth of closure in

  17. Adam Smith y el derecho

    Directory of Open Access Journals (Sweden)

    Federico Escobar Córdoba

    2004-12-01

    Full Text Available Este artículo destaca el análisis jurídico en la obra de Adam Smith y su enriquecedor método de estudiar el derecho, particularmente en sus Lecciones de jurisprudencia. Esboza el contexto jurídico de las Lecciones e informa sobre su público original. Luego, describe la presencia del derecho romano en esa obra, deteniéndose en dos aspectos que los editores de la Edición Glasgow señalaron como errores o imprecisiones. El artículo analiza estos aspectos, ofrece posibles explicaciones alternativas que, a la vez, resaltan la complejidad del pensamiento jurídico de Smith. Finalmente, identifica tres niveles de análisis, empleados por Smith en las Lecciones, cuya interacción sería una contribución importante a la dogmática jurídica contemporánea.

  18. Hurricane Rita Poster (September 22, 2005)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Rita poster. Multi-spectral image from NOAA-16 shows Hurricane Rita as a category-4 hurricane in the Gulf of Mexico on September 22, 2005. Poster size is...

  19. Hurricane Katrina Poster (August 28, 2005)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Katrina poster. Multi-spectral image from NOAA-18 shows a very large Hurricane Katrina as a category 5 hurricane in the Gulf of Mexico on August 28, 2005....

  20. A Conversation with Adam Heller.

    Science.gov (United States)

    Heller, Adam; Cairns, Elton J

    2015-01-01

    Adam Heller, Ernest Cockrell Sr. Chair in Engineering Emeritus of the John J. McKetta Department of Chemical Engineering at The University of Texas at Austin, recalls his childhood in the Holocaust and his contributions to science and technology that earned him the US National Medal of Technology and Innovation in a conversation with Elton J. Cairns, Professor of Chemical and Biomolecular Engineering at the University of California, Berkeley. Dr. Heller, born in 1933, describes the enslavement of his father by Hungarians in 1942; the confiscation of his family's home, business, and all its belongings in 1944; and his incarceration in a brick factory with 18,000 Jews who were shipped by the Hungarians to be gassed by Germans in Auschwitz. Dr. Heller and his immediate family survived the Holocaust and arrived in Israel in 1945. He studied under Ernst David Bergmann at the Hebrew University, and then worked at Bell Laboratories and GTE Laboratories, where he headed Bell Lab's Electronic Materials Research Department. At GTE Laboratories, he built in 1966 the first neodymium liquid lasers and in 1973 with Jim Auborn conceived and engineered the lithium thionyl chloride battery, one of the first to be manufactured lithium batteries, which is still in use. After joining the faculty of engineering of The University of Texas at Austin, he cofounded with his son Ephraim Heller TheraSense, now a major part of Abbott Diabetes Care, which produced a microcoulometer that made the monitoring of glucose painless by accurately measuring the blood glucose concentration in 300 nL of blood. He also describes the electrical wiring of enzymes, the basis for Abbott's state-of-the-art continuous glucose monitoring system. He discusses his perspective of reducing the risk of catastrophic global warming in a wealth-accumulating, more-energy-consuming world and provides advice for students entering careers in science or engineering.

  1. Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice

    Directory of Open Access Journals (Sweden)

    Postina Rolf

    2009-02-01

    Full Text Available Abstract Background In a transgenic mouse model of Alzheimer disease (AD, cleavage of the amyloid precursor protein (APP by the α-secretase ADAM10 prevented amyloid plaque formation, and alleviated cognitive deficits. Furthermore, ADAM10 overexpression increased the cortical synaptogenesis. These results suggest that upregulation of ADAM10 in the brain has beneficial effects on AD pathology. Results To assess the influence of ADAM10 on the gene expression profile in the brain, we performed a microarray analysis using RNA isolated from brains of five months old mice overexpressing either the α-secretase ADAM10, or a dominant-negative mutant (dn of this enzyme. As compared to non-transgenic wild-type mice, in ADAM10 transgenic mice 355 genes, and in dnADAM10 mice 143 genes were found to be differentially expressed. A higher number of genes was differentially regulated in double-transgenic mouse strains additionally expressing the human APP[V717I] mutant. Overexpression of proteolytically active ADAM10 affected several physiological pathways, such as cell communication, nervous system development, neuron projection as well as synaptic transmission. Although ADAM10 has been implicated in Notch and β-catenin signaling, no significant changes in the respective target genes were observed in adult ADAM10 transgenic mice. Real-time RT-PCR confirmed a downregulation of genes coding for the inflammation-associated proteins S100a8 and S100a9 induced by moderate ADAM10 overexpression. Overexpression of the dominant-negative form dnADAM10 led to a significant increase in the expression of the fatty acid-binding protein Fabp7, which also has been found in higher amounts in brains of Down syndrome patients. Conclusion In general, there was only a moderate alteration of gene expression in ADAM10 overexpressing mice. Genes coding for pro-inflammatory or pro-apoptotic proteins were not over-represented among differentially regulated genes. Even a decrease of

  2. How Hurricanes Get Their Names

    Institute of Scientific and Technical Information of China (English)

    张梅荐

    2000-01-01

    The first people who gave names to hurricanes were those who knew them best the people of Puerto Rico. The small island of Puerto Rico is in the West Indies, off the coast of Florida. This is where all the hurricanes begin that strike the east coast of the United States.

  3. 76 FR 63541 - Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants

    Science.gov (United States)

    2011-10-13

    ...-2010-0288] Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants AGENCY: Nuclear... Hurricane Missiles for Nuclear Power Plants.'' This regulatory guide provides licensees and applicants with... hurricane and design-basis hurricane-generated missiles that a nuclear power plant should be designed...

  4. Molecular profiling of ADAM12 in human bladder cancer

    DEFF Research Database (Denmark)

    Albrechtsen, Reidar; Dyrskjøt, Lars; Rudkjaer, Lise;

    2006-01-01

    PURPOSE: We have previously found ADAM12, a disintegrin and metalloprotease, to be an interesting biomarker for breast cancer. The purpose of this study was to determine the gene and protein expression profiles of ADAM12 in different grades and stages of bladder cancer. EXPERIMENTAL DESIGN: ADAM12...... staining on tissue arrays of bladder cancers. The presence and relative amount of ADAM12 in the urine of cancer patients were determined by Western blotting and densitometric measurements, respectively. RESULTS: ADAM12 mRNA expression was significantly up-regulated in bladder cancer, as determined...... by microarray analysis, and the level of ADAM12 mRNA correlated with disease stage. Reverse transcription-PCR, quantitative PCR, and in situ hybridization validated the gene expression results. Using immunohistochemistry, we found ADAM12 protein expression correlated with tumor stage and grade. Finally, ADAM12...

  5. Epithelial cell ADAM17 activation by Helicobacter pylori: role of ADAM17 C-terminus and Threonine-735 phosphorylation.

    Science.gov (United States)

    McClurg, Urszula L; Danjo, Kazuma; King, Harry O; Scott, Gina B; Robinson, Philip A; Crabtree, Jean E

    2015-03-01

    Helicobacter pylori transactivates the epidermal growth factor receptor (EGFR) on gastric epithelial cells via a signalling cascade involving a disintegrin and metalloprotease 17 (ADAM17) cleavage of membrane bound heparin binding-epidermal growth factor (HB-EGF). The effects of H. pylori on ADAM17 C-terminus in epithelial cells have been examined. Total cellular ADAM17 and surface expression of ADAM17 were significantly increased by H. pylori in AGS gastric epithelial cells. These changes were associated with ADAM17 C-terminal phosphorylation at T375 and S791. AGS cells lacking the ADAM17 C-terminal domain induced significantly attenuated cleavage of HB-EGF and were also unable to upregulate HB-EGF and EGFR transcripts to the same extent as cells expressing full length ADAM17. In mitotic unstimulated AGS and ADAM17 over-expressing AGS cells, ADAM17 was highly T735 phosphorylated indicating ADAM17 T735 phosphorylation is modified during the cell cycle. In conclusion, H. pylori induced ADAM17 C-terminal T735 and/or S791 phosphorylation in gastric epithelial cells are likely to be an important trigger inducing ADAM17 activation and shedding of HB-EGF leading to EGFR transactivation. ADAM17 over-expression in gastric cancer represents a potential target for therapeutic intervention.

  6. Bernardo Santareno e as possíveis reverberações das palavras de Ivan Karamázovi / Bernardo Santareno and the possible reverberations of Ivan Karamazov’s words

    Directory of Open Access Journals (Sweden)

    Fernanda Verdasca Botton

    2011-11-01

    Full Text Available RESUMO: Na peça teatral O inferno, escrita por Bernardo Santareno, o serial killer Orfeu Wilson, à beira da cova de suas vítimas, declama frases de Ivan Karamázovi, conhecidas por meio do texto de Dostoiévski e pelo ensaio O homem revoltado, de Camus. O presenteartigo tem como objetivo analisar os elementos constitutivos dessa relação entre os enunciados de Orfeu e os de Ivan. ABSTRACT: In the play O inferno, written by Bernardo Santareno, the serial killer Orfeu Wilson, at the grave of his victims, recites phrases by Ivan Karamazov, known through the text of Dostoevsky and the essay O homem revoltado, written by Camus. This article aims at analyzing the constitutive elements of the relationship between Orfeu’s and Ivan’sutterances.

  7. ARTISTIC ADAPTATION OF THE ORIGINAL SOURCE IN THE ART WORKS BY IVAN SHMELEV

    OpenAIRE

    Nikolay Ivanovich Sobolev

    2014-01-01

    The article considers one of the aspects of artistic adaptation of an original source in the art works by Ivan Shmelev. The material of article is the story of the Abbot Damaskin, and the poetic text in the essays On the Rocks of Valaam and The Old Valaam, and folklore text in the tale Inexhaustible Cap. The analysis of the genesis of the formal structure of the quotes of diff erent levels at diff erent stages of the history of essays reveals the author's intention to recreate the...

  8. Fourth year medical students’ reflective writing on “death of Ivan Ilych: a qualitative study

    Directory of Open Access Journals (Sweden)

    MAHSHID ZOHOURI

    2017-04-01

    Full Text Available Introduction: Medical students should be familiar with the end of life ethical issues and its considerations. For teaching end of life care to medical students, literature is a source of excellent narratives of patients with experiences of terminally ill condition in their journey through suffering and one of the most favourite bioethics literature readings has been the death of Ivan Ilych by Tolstoy. We used this novel to show medical students end of life events and suffering and asked them to write a reflective essay on it. We aimed to find what students think about terminally ill patients and their journey to death. Methods: In an inductive qualitative content analysis model, 350 essays, collected by homogenous sampling, were analyzed. The fourth year medical students were provided with the Death of Ivan Ilych novel to read. They were asked to write a reflection essay based on the reflective stages defined by Sandars. These essays served as the unit of analysis, each being read several times and a coding model was formed according to main topics. The related concepts in each unit were named as themes and each theme was abstracted to a code and the related codes were compared and developed as categories. Results: Qualitative content analysis of 350 essays of fourth year medical students revealed three major categories in students’ reflection on reading Death of Ivan Ilych as an end of life human body. These included: 1 Emotional experience, 2 Empathy and effective communication, 3 Spirituality and dignity. Analysis of essays showed that this reflection activity may help medical students have a deeper idea of the end of life situation and feelings. Conclusion: This project suggests that literature can be used as an example to introduce new ethical concepts to less experienced medical trainees. The students acquired the concept of the story and reflected the major aspects of the suffering of a human being in their essays. Having used and

  9. Fourth year medical students’ reflective writing on “death of Ivan Ilych: a qualitative study

    Science.gov (United States)

    ZOHOURI, MAHSHID; AMINI, MITRA; SAGHEB, MOHAMMAD MEHDI

    2017-01-01

    Introduction: Medical students should be familiar with the end of life ethical issues and its considerations. For teaching end of life care to medical students, literature is a source of excellent narratives of patients with experiences of terminally ill condition in their journey through suffering and one of the most favourite bioethics literature readings has been the death of Ivan Ilych by Tolstoy. We used this novel to show medical students end of life events and suffering and asked them to write a reflective essay on it. We aimed to find what students think about terminally ill patients and their journey to death. Methods: In an inductive qualitative content analysis model, 350 essays, collected by homogenous sampling, were analyzed. The fourth year medical students were provided with the Death of Ivan Ilych novel to read. They were asked to write a reflection essay based on the reflective stages defined by Sandars. These essays served as the unit of analysis, each being read several times and a coding model was formed according to main topics. The related concepts in each unit were named as themes and each theme was abstracted to a code and the related codes were compared and developed as categories. Results: Qualitative content analysis of 350 essays of fourth year medical students revealed three major categories in students’ reflection on reading Death of Ivan Ilych as an end of life human body. These included: 1) Emotional experience, 2) Empathy and effective communication, 3) Spirituality and dignity. Analysis of essays showed that this reflection activity may help medical students have a deeper idea of the end of life situation and feelings. Conclusion: This project suggests that literature can be used as an example to introduce new ethical concepts to less experienced medical trainees. The students acquired the concept of the story and reflected the major aspects of the suffering of a human being in their essays. Having used and evaluated the effect

  10. Fourth year medical students' reflective writing on "death of Ivan Ilych: a qualitative study.

    Science.gov (United States)

    Zohouri, Mahshid; Amini, Mitra; Sagheb, Mohammad Mehdi

    2017-04-01

    Medical students should be familiar with the end of life ethical issues and its considerations. For teaching end of life care to medical students, literature is a source of excellent narratives of patients with experiences of terminally ill condition in their journey through suffering and one of the most favourite bioethics literature readings has been the death of Ivan Ilych by Tolstoy. We used this novel to show medical students end of life events and suffering and asked them to write a reflective essay on it. We aimed to find what students think about terminally ill patients and their journey to death. In an inductive qualitative content analysis model, 350 essays, collected by homogenous sampling, were analyzed. The fourth year medical students were provided with the Death of Ivan Ilych novel to read. They were asked to write a reflection essay based on the reflective stages defined by Sandars. These essays served as the unit of analysis, each being read several times and a coding model was formed according to main topics. The related concepts in each unit were named as themes and each theme was abstracted to a code and the related codes were compared and developed as categories. Qualitative content analysis of 350 essays of fourth year medical students revealed three major categories in students' reflection on reading Death of Ivan Ilych as an end of life human body. These included: 1) Emotional experience, 2) Empathy and effective communication, 3) Spirituality and dignity. Analysis of essays showed that this reflection activity may help medical students have a deeper idea of the end of life situation and feelings. This project suggests that literature can be used as an example to introduce new ethical concepts to less experienced medical trainees. The students acquired the concept of the story and reflected the major aspects of the suffering of a human being in their essays. Having used and evaluated the effect of literature on facilitating ethical insight

  11. Sul ritrovamento di alcune miniature di Ivan Alekseevič Bunin

    Directory of Open Access Journals (Sweden)

    Jitka Křesálková

    2011-01-01

    Full Text Available Jitka KřesálkováAbout some unknown miniatures of Ivan Alekseevič BuninThe extensive check of Bunin’s writings carried out during the editing of the complete bibliography of his works led to discover some unknown miniatures. Due to an incorrect division of a series of ultra-short stories published in the Russian newspaper Последние новости (Paris, 1930, three of them had merged and disappeared.

  12. The Gerasim model of caregiving: reflections on Tolstoy's novella, The Death of Ivan Ilyich.

    Science.gov (United States)

    Taylor, S L

    1997-01-01

    Count Leo Tolstoy's classic novella The Death of Ivan Ilyich (1886/1981) is examined from the perspective of a health care professional for its portrayal of a helping relationship between the central character and his servant Gerasim. The purpose of the article is to extrapolate helping behaviors depicted in the story and construct a caregiving model. Tolstoy's work, literary critiques of the novel, biographies of Tolstoy, and principles from feminist ethics are used as sources. The model will be of assistance to those who care for the terminally ill.

  13. Women in History--Abigail Adams: Life, Accomplishments, and Ideas

    Science.gov (United States)

    Kenan, Sharon K.

    2008-01-01

    This article profiles the life, accomplishments, and ideas of Abigail Adams. Born in 1944, Adams lacked a formal education, but she more than made up for that shortcoming with her love of reading, especially literature, and her interests in politics and events surrounding the young colonies. Adams was supportive of the advancement of women. She…

  14. 应用ADAMS/car设计汽车悬架

    Institute of Scientific and Technical Information of China (English)

    殷卫乔

    2009-01-01

    ADAMS/CAR中建立麦弗逊悬架的三维模型,分析悬架参数在汽车行驶中的变化.依据ADAMS/insight,对ADAMS/car建立的模型进行悬架系统的优化求解,得到悬架系统的优化解.

  15. Role of ADAMs in cancer formation and progression.

    LENUS (Irish Health Repository)

    Duffy, Michael J

    2012-02-01

    The ADAMs (a disintegrin and metalloproteinase) comprise a family of multidomain transmembrane and secreted proteins. One of their best-established roles is the release of biologically important ligands, such as tumor necrosis factor-alpha, epidermal growth factor, transforming growth factor-alpha, and amphiregulin. Because these ligands have been implicated in the formation and progression of tumors, it might be expected that the specific ADAMs involved in their release would also be involved in malignancy. Consistent with this hypothesis, emerging data from model systems suggest that ADAMs, such as ADAM-9, ADAM-12, ADAM-15, and ADAM-17, are causally involved in tumor formation\\/progression. In human cancer, specific ADAMs are up-regulated, with levels generally correlating with parameters of tumor progression and poor outcome. In preclinical models, selective ADAM inhibitors against ADAM-10 and ADAM-17 have been shown to synergize with existing therapies in decreasing tumor growth. The ADAMs are thus a new family of potential targets for the treatment of cancer, especially malignancies that are dependent on human epidermal growth factor receptor ligands or tumor necrosis factor-alpha.

  16. A Look Inside Hurricane Alma

    Science.gov (United States)

    2002-01-01

    Hurricane season in the eastern Pacific started off with a whimper late last month as Alma, a Category 2 hurricane, slowly made its way up the coast of Baja California, packing sustained winds of 110 miles per hour and gusts of 135 miles per hour. The above image of the hurricane was acquired on May 29, 2002, and displays the rainfall rates occurring within the storm. Click the image above to see an animated data visualization (3.8 MB) of the interior of Hurricane Alma. The images of the clouds seen at the beginning of the movie were retrieved from the National Oceanic and Atmospheric Association's (NOAA's) Geostationary Orbiting Environmental Satellite (GOES) network. As the movie continues, the clouds are peeled away to reveal an image of rainfall levels in the hurricane. The rainfall data were obtained by the Precipitation Radar aboard NASA's Tropical Rainfall Measuring Mission (TRMM) satellite. The Precipitation Radar bounces radio waves off of clouds to retrieve a reading of the number of large, rain-sized droplets within the clouds. Using these data, scientists can tell how much precipitation is occurring within and beneath a hurricane. In the movie, yellow denotes areas where 0.5 inches of rain is falling per hour, green denotes 1 inch per hour, and red denotes over 2 inches per hour. (Please note that high resolution still images of Hurricane Alma are available in the NASA Visible Earth in TIFF format.) Image and animation courtesy Lori Perkins, NASA Goddard Space Flight Center Scientific Visualization Studio

  17. Paraprofessional of the Year 2009: Tina Adams

    Science.gov (United States)

    Berry, John N., III

    2009-01-01

    There is no doubt among the staff and managers at North Carolina State University (NCSU) Libraries, Raleigh, that advanced library technician Tina Adams deserves to be the winner of the "Library Journal's "Paraprofessional of the Year Award for 2009." "Certainly this library has never seen anyone like her before, not in my nine years on staff,"…

  18. Adam Smith, Religion, and Tuition Tax Credits.

    Science.gov (United States)

    Alexander, Kern

    1983-01-01

    Examines tuition tax credit programs in framework of Adam Smith's ideas on the economic impact of established churches. Finds that tuition tax credits would amount to state expenditures to relieve the financial burden of parochial school parents and would allow churches to invest commercially to maintain their charitable functions. (JW)

  19. Propagandist of the Revolution: Samuel Adams.

    Science.gov (United States)

    Scanlon, Thomas M.

    This paper explores Samuel Adam's role as perhaps the most important propagandist of the American Revolution and his efforts to exploit Great Britain's mistakes and to engender in the American colonists a love of liberty and a fear that Great Britain, if not resisted, would replace that liberty with tyranny. Suggesting that the Revolutionary War…

  20. J. B. Adams Acting Director-General

    CERN Multimedia

    1960-01-01

    After the tragic death of Prof. C. J. Bakker, the Council of CERN held an emergency meeting on May 3, 1960. Following this session, Mr. F. de Rose, President of the Council of the European Organization for Nuclear Research, announced the appointment of Mr. J. B. Adams, Director of the PS division to the post of acting Director-General.

  1. Paraprofessional of the Year 2009: Tina Adams

    Science.gov (United States)

    Berry, John N., III

    2009-01-01

    There is no doubt among the staff and managers at North Carolina State University (NCSU) Libraries, Raleigh, that advanced library technician Tina Adams deserves to be the winner of the "Library Journal's "Paraprofessional of the Year Award for 2009." "Certainly this library has never seen anyone like her before, not in my nine…

  2. Adam Smith and the Rhetoric of Style.

    Science.gov (United States)

    Moran, Michael G.

    Historians of rhetoric have generally accepted the view that Adam Smith rejected the principles of classical rhetoric. However, while there can be no doubt that Smith greatly truncated the five classical arts of rhetoric (invention, arrangement, style, memory, and delivery) by reducing his concerns largely to style and arrangement, he did not…

  3. Adam Smith, Religion, and Tuition Tax Credits.

    Science.gov (United States)

    Alexander, Kern

    1983-01-01

    Examines tuition tax credit programs in framework of Adam Smith's ideas on the economic impact of established churches. Finds that tuition tax credits would amount to state expenditures to relieve the financial burden of parochial school parents and would allow churches to invest commercially to maintain their charitable functions. (JW)

  4. Application of ADAMS/CAR in Macpherson suspension%ADAMS/CAR在麦弗逊悬架中的应用

    Institute of Scientific and Technical Information of China (English)

    朱天军; 郑红艳; 王玉昆

    2005-01-01

    ADAMS/CAR中建立麦弗逊悬架的三维模型,分析悬架参数在汽车行驶中的变化.依据ADAMS/Insight,对ADAMS/CAR建立的模型进行悬架系统的优化求解,得到悬架系统的优化解.

  5. Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes.

    Science.gov (United States)

    Lee, Hee Doo; Koo, Bon-Hun; Kim, Yeon Hyang; Jeon, Ok-Hee; Kim, Doo-Sik

    2012-07-01

    A disintegrin and metalloproteinase 15 (ADAM15), the only ADAM protein containing an Arg-Gly-Asp (RGD) motif in its disintegrin-like domain, is a widely expressed membrane protein that is involved in tumor progression and suppression. However, the underlying mechanism of ADAM15-mediated tumor suppression is not clearly understood. This study demonstrates that ADAM15 is released as an exosomal component, and ADAM15 exosomes exert tumor suppressive activities. We found that exosomal ADAM15 release is stimulated by phorbol 12-myristate 13-acetate, a typical protein kinase C activator, in various tumor cell types, and this results in a corresponding decrease in plasma membrane-associated ADAM15. Exosomes rich in ADAM15 display enhanced binding affinity for integrin αvβ3 in an RGD-dependent manner and suppress vitronectin- and fibronectin-induced cell adhesion, growth, and migration, as well as in vivo tumor growth. Exosomal ADAM15 is released from human macrophages, and macrophage-derived ADAM15 exosomes have tumor inhibitory effects. This work suggests a primary role of ADAM15 for exosome-mediated tumor suppression, as well as functional significance of exosomal ADAM protein in antitumor immunity.

  6. Cellular roles of ADAM12 in health and disease

    DEFF Research Database (Denmark)

    Kveiborg, Marie; Albrechtsen, Reidar; Couchman, John R;

    2008-01-01

    and it is a potential biomarker for breast cancer. It is therefore important to understand ADAM12's functions. Many cellular roles for ADAM12 have been suggested. It is an active metalloprotease, and has been implicated in insulin-like growth factor (IGF) receptor signaling, through cleavage of IGF-binding proteins...... to or from the cell interior. These ADAM12-mediated cellular effects appear to be critical events in both biological and pathological processes. This review presents current knowledge on ADAM12 functions gained from in vitro and in vivo observations, describes ADAM12's role in both normal physiology...

  7. Molecular profiling of ADAM12 in human bladder cancer

    DEFF Research Database (Denmark)

    Frolich, Camilla; Albrechtsen, Reidar; Andersen, Lars Dyrskjøt

    2006-01-01

    by microarray analysis, and the level of ADAM12 mRNA correlated with disease stage. Reverse transcription-PCR, quantitative PCR, and in situ hybridization validated the gene expression results. Using immunohistochemistry, we found ADAM12 protein expression correlated with tumor stage and grade. Finally, ADAM12...... could be detected in the urine by Western blotting; ADAM12 was present in higher levels in the urine from patients with bladder cancer compared with urine from healthy individuals. Significantly, following removal of tumor by surgery, in most bladder cancer cases examined, the level of ADAM12...

  8. Illnesses of the brain in John Quincy Adams.

    Science.gov (United States)

    Paulson, George

    2004-12-01

    John Quincy Adams, the sixth and perhaps most scholarly American president, served courageously despite familial essential tremor, depression, and cerebrovascular disease. His cousin Samuel Adams and his father John Adams also had essential tremor, which the later called "quiveration". Alcoholism and depression affected several members of J.Q. Adams's family. Following his own time as president, J.Q. Adams returned to duty as the congressman who most assiduously fought slavery, a fight he continued even after he had suffered a major left hemispheric stroke. His fatal collapse in Congress, protesting the Mexican War, is legendary among the final illnesses of American statesmen.

  9. Household Adjustments to Hurricane Katrina

    National Research Council Canada - National Science Library

    Meri Davlasheridze; Qin Fan

    2017-01-01

    This paper examines household adjustments to Hurricane Katrina by estimating the effects of Katrina-induced damages on changes in household demographics and income distributions in the Orleans Parish...

  10. Climate change: Unattributed hurricane damage

    Science.gov (United States)

    Hallegatte, Stéphane

    2015-11-01

    In the United States, hurricanes have been causing more and more economic damage. A reanalysis of the disaster database using a statistical method that accounts for improvements in resilience opens the possibility that climate change has played a role.

  11. The Hurricane and Its Impact

    Science.gov (United States)

    Burpee, Robert W.

    Recent population increases in coastal regions of the tropics and subtropics have greatly enhanced man's vulnerability to tropical cyclones. Thus, this book on hurricanes by Robert H. Simpson and Herbert Riehl, two of the leading contributors to hurricane research during the last 35 years, comes along when people of differing backgrounds want to learn more about hurricanes. In the 20 years since Dunn and Miller published Atlantic Hurricanes, technical advances in weather satellites, computer modeling and data processing, and research aircraft have substantially increased the tropical meteorologist's understanding of hurricane structure and dynamics. During this same time, field experiments have led to detailed knowledge of the atmospheric environment within which tropical cyclones are initiated. The authors have attempted to describe many aspects of hurricanes for readers that range from students of meteorology to those concerned with planning for natural hazards in the coastal zone. Because Simpson and Riehl have addressed such a wide audience, many readers with a knowledge of atmospheric science will find that the book is overly descriptive, while readers without some background in physics will find it is too technical.

  12. MBS Analysis Of Kinetic Structures Using ADAMS

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Nielsen, Søren R.K.

    2009-01-01

    The present paper considers multibody system (MBS) analysis of kinetic structures using the software package ADAMS. Deployable, foldable, expandable and reconfigurable kinetic structures can provide a change in the geometric morphology of the envelope by contributing to making it adaptable to e.......g. changing external climate factors, in order to improve the indoor climate performance of the building. The derivation of equations of motion for such spatial mechanical systems is a challenging issue in scientific community. However, with new symbolic tools one can automatically derive equations in so......-called multibody system (MBS) formalism. The present paper considers MBS modeling of kinetic architectural structures using the software packages ADAMS. As a result, it is found that symbolic MBS simulation tools facilitate a useful evaluation environment for MBS users during a design phase of responsive kinetic...

  13. ADAMS Q&A%ADAMS问答

    Institute of Scientific and Technical Information of China (English)

    陈志宇; 杨晓晔; 邱娴婷

    2012-01-01

    ADAMS is an anti-doping operational network data management system, which was set up at the middle of 2005, aiming to simplify the daily activities of various concerned beneficial parts and athletes in anti-doping work. The four crucial functions of ADAMS in anti-doping work are as follows: athlete whereabouts information management, information processing hub, doping control panel and therapeutic use exemption management.%1什么是ADAMS? 《世界反兴奋剂条例》规定,世界反兴奋剂机构(以下简称WADA)有义务协调全球反兴奋剂工作,并提供利益相关方执行该条例的机制。

  14. Adam Smith: Anthropology and Moral Philosophy

    OpenAIRE

    Lázaro-Cantero, R. (Raquel)

    2010-01-01

    Adam Smith was a moral philosopher. His economic and legal thought can't be separated from his moral psychology which frames his anthropological and social proposal. Experimental Newtonian methodology and Hume's empirism feed his approximation to the reality of human being. In this new context the traditional categories of society are defined and combined in a new way. In this paper I try to argue that the assumed optimism which sometimes is attributed to Smith about the proper functioning of...

  15. Adam Smith, Market and Social Change

    DEFF Research Database (Denmark)

    Bouchet, Dominique

    2017-01-01

    Adam Smith (1723-1790) provided us with a remarkable synthesis of the economic and political ideas of his time and developed a conceptual system to analyse social interactions that mattered for the wealth of nations. He proposed a radically different roadmap for the future development of the soci......Adam Smith (1723-1790) provided us with a remarkable synthesis of the economic and political ideas of his time and developed a conceptual system to analyse social interactions that mattered for the wealth of nations. He proposed a radically different roadmap for the future development...... of the society he lived in. The fact that his original analyses were rooted in a given historical context and were founded on a well thought-through conceptual system should not be ignored. The galvanising effect of the dribs and drabs of Adam Smith ideas that have been bandied about are a long way from...... the powerful insights imbued in the original ideas. Putting those back into context, looking into how Smith proceeded then, trying to update his observations, might help us to be more attentive to the market changes and social challenges of our times....

  16. Hurricane Data Analysis Tool

    Science.gov (United States)

    Liu, Zhong; Ostrenga, Dana; Leptoukh, Gregory

    2011-01-01

    In order to facilitate Earth science data access, the NASA Goddard Earth Sciences Data Information Services Center (GES DISC) has developed a web prototype, the Hurricane Data Analysis Tool (HDAT; URL: http://disc.gsfc.nasa.gov/HDAT), to allow users to conduct online visualization and analysis of several remote sensing and model datasets for educational activities and studies of tropical cyclones and other weather phenomena. With a web browser and few mouse clicks, users can have a full access to terabytes of data and generate 2-D or time-series plots and animation without downloading any software and data. HDAT includes data from the NASA Tropical Rainfall Measuring Mission (TRMM), the NASA Quick Scatterometer(QuikSCAT) and NECP Reanalysis, and the NCEP/CPC half-hourly, 4-km Global (60 N - 60 S) IR Dataset. The GES DISC archives TRMM data. The daily global rainfall product derived from the 3-hourly multi-satellite precipitation product (3B42 V6) is available in HDAT. The TRMM Microwave Imager (TMI) sea surface temperature from the Remote Sensing Systems is in HDAT as well. The NASA QuikSCAT ocean surface wind and the NCEP Reanalysis provide ocean surface and atmospheric conditions, respectively. The global merged IR product, also known as, the NCEP/CPC half-hourly, 4-km Global (60 N -60 S) IR Dataset, is one of TRMM ancillary datasets. They are globally-merged pixel-resolution IR brightness temperature data (equivalent blackbody temperatures), merged from all available geostationary satellites (GOES-8/10, METEOSAT-7/5 & GMS). The GES DISC has collected over 10 years of the data beginning from February of 2000. This high temporal resolution (every 30 minutes) dataset not only provides additional background information to TRMM and other satellite missions, but also allows observing a wide range of meteorological phenomena from space, such as, hurricanes, typhoons, tropical cyclones, mesoscale convection system, etc. Basic functions include selection of area of

  17. ESTIMATION OF POLLUTANT LOAD IN DRINKING WATER PROTECTION AREAS OF SPRINGS SV. IVAN, BULAŽ, AND GRADOLE

    Directory of Open Access Journals (Sweden)

    Rino Nemarnik

    2016-12-01

    Full Text Available In this paper, the estimation of pollutant load within the drinking water protection areas (DWPA of springs Sv. Ivan, Bulaž, and Gradole in Northern Istria (Croatia is presented. To estimate the pollution load, the spreadsheet tool for estimating pollutant load (STEPL model was used. STEPL calculates loads of organic pollutants, nutrients, and suspended solids. For each analyzed spring total, specific and pollutant loads by each analyzed category are calculated. The results show that the greatest loads are caused by human activities. In addition, for the purpose of the analysis, two additional future scenarios are introduced; one describes the situation after the implementation of the first phase of the Istrian water protection system project, and the other that describes a possible future state where each agglomeration of over 100 inhabitants within the protected areas has an adequate wastewater treatment plant (WWTP.

  18. Consciousness eclipsed: Jacques Loeb, Ivan P. Pavlov, and the rise of reductionistic biology after 1900.

    Science.gov (United States)

    Greenspan, Ralph J; Baars, Bernard J

    2005-03-01

    The life sciences in the 20th century were guided to a large extent by a reductionist program seeking to explain biological phenomena in terms of physics and chemistry. Two scientists who figured prominently in the establishment and dissemination of this program were Jacques Loeb in biology and Ivan P. Pavlov in psychological behaviorism. While neither succeeded in accounting for higher mental functions in physical-chemical terms, both adopted positions that reduced the problem of consciousness to the level of reflexes and associations. The intellectual origins of this view and the impediment to the study of consciousness as an object of inquiry in its own right that it may have imposed on peers, students, and those who followed is explored.

  19. The death of Ivan Ilych: A blueprint for intervention at the end of life.

    Science.gov (United States)

    Papadimos, Thomas J; Stawicki, Stanislaw Pa

    2011-07-01

    Medical practice and the field of humanities frequently intersect. It is uncanny how problems presented or described in literature that are several hundred years old still present themselves to us on a regular basis. Often, our answers to these dilemmas are not perfect, but we continue our attempts at providing solutions through an enlightened evolution of our thought and approaches. Leo Tolstoy's novella, The Death of Ivan Ilych, is a classic piece of literature that allows a view of the dying process in an ordinary human being, and presents us with an opportunity to observe, not only the intersection of medicine and humanities, but also that of critical care and palliative medicine. Here Tolstoy, through his keen observation of the human condition at the end of life, allows us an opportunity to view a 19(th) century perspective that has an all too familiar persistence that needs a 21(st) century intervention.

  20. The discipline of architecture and freedom of spirit: Architect Ivan Antić

    Directory of Open Access Journals (Sweden)

    Milašinović-Marić Dijana

    2005-01-01

    Full Text Available Each epoch has its distinct characters who, by their talent, creativity knowledge and skills, manage to surmount the limiting context and come up as individuals. One among such creators is the architect – Ivan Antić, Member of Academy, who in his design projects and with his distinct architectural credo managed to express the ideals of time in which he was creating. His buildings – masterpieces of the Serbian modern architecture, e.g. Museum of the modern art located at Ušće in Belgrade; Museum for victims of execution in Šumarice sport arenas, public and business edifices, all of them represent unique architectural achievements. Those building forms are both functional and aesthetical, almost as a sublimate in fulfillment of content and construction requirements.

  1. Hurricane Wilma Poster (October 24, 2005)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Wilma poster. Multi-spectral image from NOAA-18 shows Hurricane Wilma exiting Florida off the east Florida coast on October 24, 2005. Poster size is 34"x30".

  2. Hurricane Hugo Poster (September 21, 1989)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Hugo poster. Multi-spectral image from NOAA-11 captures Hurricane Hugo slamming into South Carolina coast on September 21, 1989. Poster size is 36"x36".

  3. Hurricane Sandy Poster (October 29, 2012)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Sandy poster. Multi-spectral image from Suomi-NPP shows Hurricane Sandy approaching the New Jersey Coast on October 29, 2012. Poster size is approximately...

  4. Hurricane Jeanne Poster (September 25, 2004)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Jeanne poster. Multi-spectral image from NOAA-16 shows Hurricane Jeanne near Grand Bahama Island on September 25, 2004. Poster size is 34"x30".

  5. Hurricane Charley Poster (August 13, 2004)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Charley poster. Multi-spectral image from NOAA-17 shows a small but powerful hurricane heading toward southern Florida on August 13, 2004. Poster dimension...

  6. Hurricane Isabel Poster (September 18, 2003)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Isabel poster. Multi-spectral image from NOAA-17 shows Hurricane Isabel making landfall on the North Carolina Outer Banks on September 18, 2003. Poster...

  7. Hurricane Frances Poster (September 5, 2004)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Frances poster. Multi-spectral image from NOAA-17 shows Hurricane Frances over central Florida on September 5, 2004. Poster dimension is approximately...

  8. Metalloproteinases ADAM10 and ADAM17 Mediate Migration and Differentiation in Glioblastoma Sphere-Forming Cells.

    Science.gov (United States)

    Siney, Elodie J; Holden, Alexander; Casselden, Elizabeth; Bulstrode, Harry; Thomas, Gareth J; Willaime-Morawek, Sandrine

    2017-07-01

    Glioblastoma is the most common form of primary malignant brain tumour. These tumours are highly proliferative and infiltrative resulting in a median patient survival of only 14 months from diagnosis. The current treatment regimens are ineffective against the small population of cancer stem cells residing in the tumourigenic niche; however, a new therapeutic approach could involve the removal of these cells from the microenvironment that maintains the cancer stem cell phenotype. We have isolated multipotent sphere-forming cells from human high grade glioma (glioma sphere-forming cells (GSCs)) to investigate the adhesive and migratory properties of these cells in vitro. We have focused on the role of two closely related metalloproteinases ADAM10 and ADAM17 due to their high expression in glioblastoma and GSCs and their ability to activate cytokines and growth factors. Here, we report that ADAM10 and ADAM17 inhibition selectively increases GSC, but not neural stem cell, migration and that the migrated GSCs exhibit a differentiated phenotype. We also observed a correlation between nestin, a stem/progenitor marker, and fibronectin, an extracellular matrix protein, expression in high grade glioma tissues. GSCs adherence on fibronectin is mediated by α5β1 integrin, where fibronectin further promotes GSC migration and is an effective candidate for in vivo cancer stem cell migration out of the tumourigenic niche. Our results suggest that therapies against ADAM10 and ADAM17 may promote cancer stem cell migration away from the tumourigenic niche resulting in a differentiated phenotype that is more susceptible to treatment.

  9. Catalytic properties of ADAM12 and its domain deletion mutants

    DEFF Research Database (Denmark)

    Jacobsen, Jonas; Visse, Robert; Sørensen, Hans Peter

    2008-01-01

    Human ADAM12 (a disintegrin and metalloproteinase) is a multidomain zinc metalloproteinase expressed at high levels during development and in human tumors. ADAM12 exists as two splice variants: a classical type 1 membrane-anchored form (ADAM12-L) and a secreted splice variant (ADAM12-S) consisting...... of pro, catalytic, disintegrin, cysteine-rich, and EGF domains. Here we present a novel activity of recombinant ADAM12-S and its domain deletion mutants on S-carboxymethylated transferrin (Cm-Tf). Cleavage of Cm-Tf occurred at multiple sites, and N-terminal sequencing showed that the enzyme exhibits...... restricted specificity but a consensus sequence could not be defined as its subsite requirements are promiscuous. Kinetic analysis revealed that the noncatalytic C-terminal domains are important regulators of Cm-Tf activity and that ADAM12-PC consisting of the pro domain and catalytic domain is the most...

  10. Forecasting Hurricane by Satellite Image

    Science.gov (United States)

    Liu, M. Y.

    Earth is an endanger planet. Severe weather, especially hurricanes, results in great disaster all the world. World Meteorology Organization and United Nations Environment Program established intergovernment Panel on Climate Change (IPCC) to offer warnings about the present and future disasters of the Earth. It is the mission for scientists to design warning system to predict the severe weather system and to reduce the damage of the Earth. Hurricanes invade all the world every year and made millions damage to all the people. Scientists in weather service applied satellite images and synoptic data to forecast the information for the next hours for warning purposes. Regularly, hurricane hits on Taiwan island directly will pass through her domain and neighbor within 10 hours. In this study, we are going to demonstrate a tricky hurricane NARI invaded Taiwan on September 16, 2000. She wandered in the neighborhood of the island more than 72 hours and brought heavy rainfall over the island. Her track is so tricky that scientists can not forecast her path using the regular method. Fortunately, all scientists in the Central Weather Bureau paid their best effort to fight against the tricky hurricane. Applying the new developed technique to analysis the satellite images with synoptic data and radar echo, scientists forecasted the track, intensity and rainfall excellently. Thus the damage of the severe weather reduced significantly.

  11. Atlantic hurricane response to geoengineering

    Science.gov (United States)

    Moore, John; Grinsted, Aslak; Ji, Duoying; Yu, Xiaoyong; Guo, Xiaoran

    2015-04-01

    Devastating Atlantic hurricanes are relatively rare events. However their intensity and frequency in a warming world may rapidly increase - perhaps by a factor of 5 for a 2°C mean global warming. Geoengineering by sulphate aerosol injection preferentially cools the tropics relative to the polar regions, including the hurricane main development region in the Atlantic, suggesting that geoengineering may be an effective method of controlling hurricanes. We examine this hypothesis using 6 Earth System Model simulations of climate under the GeoMIP G3 and G4 schemes that use aerosols to reduce the radiative forcing under the RCP4.5 scenario. We find that although temperatures are ameliorated by geoengineering, the numbers of storm surge events as big as that caused the 2005 Katrina hurricane are only slightly reduced compared with no geoengineering. As higher levels of sulphate aerosol injection produce diminishing returns in terms of cooling, but cause undesirable effects in various regions, it seems that stratospheric aerosol geoengineering is not an effective method of controlling hurricane damage.

  12. Year-ahead prediction of US landfalling hurricane numbers: intense hurricanes

    OpenAIRE

    Khare, Shree; Jewson, Stephen

    2005-01-01

    We continue with our program to derive simple practical methods that can be used to predict the number of US landfalling hurricanes a year in advance. We repeat an earlier study, but for a slightly different definition landfalling hurricanes, and for intense hurricanes only. We find that the averaging lengths needed for optimal predictions of numbers of intense hurricanes are longer than those needed for optimal predictions of numbers of hurricanes of all strengths.

  13. 7 CFR 701.50 - 2005 hurricanes.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false 2005 hurricanes. 701.50 Section 701.50 Agriculture... ADMINISTERED UNDER THIS PART § 701.50 2005 hurricanes. In addition benefits elsewhere allowed by this part, claims related to calendar year 2005 hurricane losses may be allowed to the extent provided for in §§ 701...

  14. Hurricane Katrina impacts on Mississippi forests

    Science.gov (United States)

    Sonja N. Oswalt; Christopher Oswalt; Jeffery Turner

    2008-01-01

    Hurricane Katrina triggered public interest and concern for forests in Mississippi that required rapid responses from the scientific community. A uniform systematic sample of 3,590 ground plots were established and measured in 687 days immediately after the impact of Hurricane Katrina on the Gulf Coast. The hurricane damaged an estimated 521 million trees with more...

  15. Hurricane Hazel: Canada's storm of the century

    National Research Council Canada - National Science Library

    Gifford, Jim

    2004-01-01

    ... For EleanorHurricane_Hazel_Interior.qxd 6/22/04 3:35 PM Page 3 HURRICANE HAZEL Canada's Storm of the Century Jim Gifford The dundurn Group Toronto * OxfordHurricane_Hazel_Interior.qxd 6/22/04 3:35...

  16. Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia

    DEFF Research Database (Denmark)

    Laigaard, Jennie; Sørensen, Tina; Placing, Sophie;

    2005-01-01

    OBJECTIVES: The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia. METHODS: We developed a semiautomated, time-resolved, immu......OBJECTIVES: The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia. METHODS: We developed a semiautomated, time......-resolved, immunofluorometric assay for the quantification of ADAM12 in serum. The assay detected ADAM12 in a range of 78-1248 microg/L. Serum samples derived from women in the first trimester of a normal pregnancy (n = 324) and from women who later developed preeclampsia during pregnancy (n = 160) were obtained from the First...... Trimester Copenhagen Study. ADAM12 levels were assayed in these serum samples. Serum levels of ADAM12 were converted to multiples of the median (MoM) after log-linear regression of concentration versus gestational age. RESULTS: Serum ADAM12 levels in women who developed preeclampsia during pregnancy had...

  17. A Universal Hurricane Frequency Function

    CERN Document Server

    Ehrlich, Robert

    2010-01-01

    Evidence is provided that the global distribution of tropical hurricanes is principally determined by a universal function H of a single variable z that in turn is expressible in terms of the local sea surface temperature and latitude. The data-driven model presented here carries stark implications for the large increased numbers of hurricanes which it predicts for a warmer world. Moreover, the rise in recent decades in the numbers of hurricanes in the Atlantic, but not the Pacific basin, is shown to have a simple explanation in terms of the specific form of H(z), which yields larger percentage increases when a fixed increase in sea surface temperature occurs at higher latitudes and lower temperatures.

  18. Generic Hurricane Extreme Seas State

    DEFF Research Database (Denmark)

    Wehmeyer, Christof; Skourup, Jesper; Frigaard, Peter

    2012-01-01

    Extreme sea states, which the IEC 61400-3 (2008) standard requires for the ultimate limit state (ULS) analysis of offshore wind turbines are derived to establish the design basis for the conceptual layout of deep water floating offshore wind turbine foundations in hurricane affected areas...... data is required for a type specific conceptual design. ULS conditions for different return periods are developed, which can subsequently be applied in siteindependent analysis and conceptual design. Recordings provided by National Oceanic and Atmospheric Administration (NOAA), of hurricanes along...... for hurricane generates seas by Young (1998, 2003, and 2006), requiring maximum wind speeds, forward velocity and radius to maximum wind speed. An averaged radius to maximum sustained wind speeds, according to Hsu et al. (1998) and averaged forward speed of cyclonic storms are applied in the initial state...

  19. The dynamics of hurricane balls

    Science.gov (United States)

    Andersen, W. L.; Werner, Steven

    2015-09-01

    We examine the theory of the hurricane balls toy. This toy consists of two steel balls, welded together that are sent spinning on a horizontal surface somewhat like a top. Unlike a top, at high frequency the symmetry axis approaches a limiting inclination that is not perpendicular to the surface. We calculate (and experimentally verify) the limiting inclinations for three toy geometries. We find that at high frequencies, hurricane balls provide an easily realized and testable example of the Poinsot theory of freely rotating symmetrical bodies.

  20. Hurricane Season: Are You Ready?

    Centers for Disease Control (CDC) Podcasts

    2012-09-24

    Hurricanes are one of Mother Nature’s most powerful forces. Host Bret Atkins talks with CDC’s National Center for Environmental Health Director Dr. Chris Portier about the main threats of a hurricane and how you can prepare.  Created: 9/24/2012 by Office of Public Health Preparedness and Response (OPHPR), National Center for Environmental Health (NCEH), and the Agency for Toxic Substances and Disease Registry (ATSDR).   Date Released: 9/24/2012.

  1. Adam Michnik: kriisis Euroopat ohustab rahvuslik egoism / Adam Michnik ; interv. Külli-Riin Tigasson

    Index Scriptorium Estoniae

    Michnik, Adam, 1946-

    2009-01-01

    Poola suurima kvaliteetlehe Gazeta Wyborczka petoimetaja Adam Michnik vastab küsimustele, mis puudutavad 2008. aastal alanud majanduskriisi, protektsionismi ja egoismi levikut, Ida-Euroopas levinud poliitilise ja majandusliku mudeli ümber hindamist, ladinaameerikalikku putinismi ja antikommunistlikku autoritaarsust ning trükiajakirjanduse tulevikku internetiajastul. Vt. samas: Elulugu

  2. From Adam Swift to Adam Smith: How the "Invisible Hand" Overcomes Middle Class Hypocrisy

    Science.gov (United States)

    Tooley, James

    2007-01-01

    This paper challenges Richard Pring's suggestion that parents using private education may be undermining the desire for social justice and equality, using recent arguments of Adam Swift as a springboard. Swift's position on the banning of private schools, which uses a Rawlsian "veil of ignorance" argument, is explored, and it is suggested that, if…

  3. Adam Michnik: kriisis Euroopat ohustab rahvuslik egoism / Adam Michnik ; interv. Külli-Riin Tigasson

    Index Scriptorium Estoniae

    Michnik, Adam, 1946-

    2009-01-01

    Poola suurima kvaliteetlehe Gazeta Wyborczka petoimetaja Adam Michnik vastab küsimustele, mis puudutavad 2008. aastal alanud majanduskriisi, protektsionismi ja egoismi levikut, Ida-Euroopas levinud poliitilise ja majandusliku mudeli ümber hindamist, ladinaameerikalikku putinismi ja antikommunistlikku autoritaarsust ning trükiajakirjanduse tulevikku internetiajastul. Vt. samas: Elulugu

  4. From Adam Swift to Adam Smith: How the "Invisible Hand" Overcomes Middle Class Hypocrisy

    Science.gov (United States)

    Tooley, James

    2007-01-01

    This paper challenges Richard Pring's suggestion that parents using private education may be undermining the desire for social justice and equality, using recent arguments of Adam Swift as a springboard. Swift's position on the banning of private schools, which uses a Rawlsian "veil of ignorance" argument, is explored, and it is suggested that, if…

  5. Adam Smith on public expenditure and taxation

    Directory of Open Access Journals (Sweden)

    Maurício C. Coutinho

    2001-01-01

    Full Text Available This paper presents Adam Smith’s view on taxation and public expenditure, by means of an almost literal reading of the Wealth of Nations famous passages on the "duties of the sovereign" and on the "maxims of taxation". Contrarily to the commonest usage of these passages, we will show that their core is the preoccupation with the public expenditure soaring and the defence of decentralisation. Furthermore and also contrarily to the existing interpretations we defend the non-existence of any contradiction between Smith’s income and price theory (and the incidence hypothesis, provided due attention is paid to the guiding role of the "maxims".

  6. Shedding of klotho by ADAMs in the kidney

    NARCIS (Netherlands)

    van Loon, Ellen P. M.; Pulskens, Wilco P.; van der Hagen, Eline A. E.; Lavrijsen, Marla; Vervloet, Marc G.; van Goor, Harry; Bindels, Rene J. M.; Hoenderop, Joost G. J.

    2015-01-01

    The anti-aging gene klotho plays an important role in Ca2+ and phosphate homeostasis. Membrane-bound klotho is an essential coreceptor for fibroblast growth factor-23 and can be cleaved by proteases, including a disintegrin and metalloproteinase (ADAM) 10 and ADAM17. Cleavage of klotho occurs at a s

  7. Shedding of klotho by ADAMs in the kidney.

    NARCIS (Netherlands)

    Loon, E.P.M. van; Pulskens, W.P.C.; Hagen, E.A.E. van der; Lavrijsen, M.; Vervloet, M.G.; Goor, H van; Bindels, R.J.M.; Hoenderop, J.G.J.

    2015-01-01

    The anti-aging gene klotho plays an important role in Ca(2+) and phosphate homeostasis. Membrane-bound klotho is an essential coreceptor for fibroblast growth factor-23 and can be cleaved by proteases, including a disintegrin and metalloproteinase (ADAM)10 and ADAM17. Cleavage of klotho occurs at a

  8. Om strukturledighed og Phillips-kurver i SMEC og ADAM

    DEFF Research Database (Denmark)

    Harck, Søren H.

    2001-01-01

    indeholder dels (ny) dokumentation af, at ADAM og SMEC (som antydet af PS) vitterligt bliver fortolket som NAIRU-modeller af prominente og toneangivende modelbrugere, og dels rummer indlægget (nye) teoretiske argumenter for, at ADAM og SMEC ikke indeholder en teoretisk veldefineret strukturarbejdsløshed...

  9. The Failed Educations of John Stuart Mill and Henry Adams.

    Science.gov (United States)

    Crossley, Robert

    1979-01-01

    Analyzes and contrasts Mill's "Autobiography" and Adams'"The Education of Henry Adams" in order to present two approaches to the nature of education and of failure. Maintains that their perspectives may serve as catalysts and cautions for contemporary theories of education and its utility and relevance. (CAM)

  10. Adams Predictor-Corrector Systems for Solving Fuzzy Differential Equations

    Directory of Open Access Journals (Sweden)

    Dequan Shang

    2013-01-01

    Full Text Available A predictor-corrector algorithm and an improved predictor-corrector (IPC algorithm based on Adams method are proposed to solve first-order differential equations with fuzzy initial condition. These algorithms are generated by updating the Adams predictor-corrector method and their convergence is also analyzed. Finally, the proposed methods are illustrated by solving an example.

  11. Shedding of klotho by ADAMs in the kidney.

    NARCIS (Netherlands)

    Loon, E.P.M. van; Pulskens, W.P.C.; Hagen, E.A.E. van der; Lavrijsen, M.; Vervloet, M.G.; Goor, H van; Bindels, R.J.M.; Hoenderop, J.G.J.

    2015-01-01

    The anti-aging gene klotho plays an important role in Ca(2+) and phosphate homeostasis. Membrane-bound klotho is an essential coreceptor for fibroblast growth factor-23 and can be cleaved by proteases, including a disintegrin and metalloproteinase (ADAM)10 and ADAM17. Cleavage of klotho occurs at a

  12. Shedding of klotho by ADAMs in the kidney

    NARCIS (Netherlands)

    van Loon, Ellen P. M.; Pulskens, Wilco P.; van der Hagen, Eline A. E.; Lavrijsen, Marla; Vervloet, Marc G.; van Goor, Harry; Bindels, Rene J. M.; Hoenderop, Joost G. J.

    2015-01-01

    The anti-aging gene klotho plays an important role in Ca2+ and phosphate homeostasis. Membrane-bound klotho is an essential coreceptor for fibroblast growth factor-23 and can be cleaved by proteases, including a disintegrin and metalloproteinase (ADAM) 10 and ADAM17. Cleavage of klotho occurs at a

  13. A brief critique of the Adam-Gibbs entropy model

    DEFF Research Database (Denmark)

    Dyre, J. C.; Hecksher, Tina; Niss, Kristine

    2009-01-01

    This paper critically discusses the entropy model proposed by Adam and Gibbs in 1965 for the dramatic temperature dependence of glass-forming liquids' average relaxation time, which is one of the most influential models during the last four decades. We discuss the Adam-Gibbs model's theoretical...

  14. The plasma membrane: Penultimate regulator of ADAM sheddase function.

    Science.gov (United States)

    Reiss, Karina; Bhakdi, Sucharit

    2017-11-01

    ADAM10 and ADAM17 are the best characterized members of the ADAM (A Disintegrin and Metalloproteinase) - family of transmembrane proteases. Both are involved diverse physiological and pathophysiological processes. ADAMs are known to be regulated by posttranslational mechanisms. However, emerging evidence indicates that the plasma membrane with its unique dynamic properties may additionally play an important role in controlling sheddase function. Membrane events that could contribute to regulation of ADAM-function are summarized. Surface expression of peptidolytic activity should be differentiated from ADAM-sheddase function since the latter additionally requires that the protease finds its substrate in the lipid bilayer. We propose that this is achieved through horizontal and vertical reorganization of membrane nanoarchitecture coordinately occurring at the sites of sheddase activation. Reshuffling of nanodomains thereby guides traffic of enzyme and substrate to each other. For ADAM17 phosphatidylserine exposure is required to then induce its shedding function. The novel concept that physicochemical properties of the lipid bilayer govern the action of ADAM-proteases may be extendable to other functional proteins that act at the cell surface. This article is part of a Special Issue entitled: Proteolysis as a Regulatory Event in Pathophysiology edited by Stefan Rose-John. Copyright © 2017. Published by Elsevier B.V.

  15. The Failed Educations of John Stuart Mill and Henry Adams.

    Science.gov (United States)

    Crossley, Robert

    1979-01-01

    Analyzes and contrasts Mill's "Autobiography" and Adams'"The Education of Henry Adams" in order to present two approaches to the nature of education and of failure. Maintains that their perspectives may serve as catalysts and cautions for contemporary theories of education and its utility and relevance. (CAM)

  16. Hierarchy of ADAM12 binding to integrins in tumor cells

    DEFF Research Database (Denmark)

    Thodeti, Charles Kumar; Fröhlich, Camilla; Nielsen, Christian Kamp

    2005-01-01

    ADAMs (a disintegrin and metalloprotease) comprise a family of cell surface proteins with protease and cell-binding activities. Using different forms and fragments of ADAM12 as substrates in cell adhesion and spreading assays, we demonstrated that alpha9beta1 integrin is the main receptor for ADA...

  17. Lukisan Ivan Sagita “Makasih Kollwitz” (2005) dalam Sejarah Seni Lukis Modern Indonesia: Tinjauan Ikonografi dan Ikonologi

    OpenAIRE

    M. Agus Burhan

    2015-01-01

    Penelitian ini menganalisis karya seni lukis berjudul “Makasih Kollwitz” (2005), yang dilu- kis oleh Ivan Sagita. Dengan menggunakan sejarah seni sebagai dasar pendekatan, selanjutnya pilihan teori utama yang dipakai adalah teori ikonografi dan ikonologi Erwin Panofsky. Metode penelitian sejarah meliputi, pencarian data di lapangan dan sumber-sumber pustaka, seleksi dan kritik data, analisis dan interpretasi data untuk menghasilkan sintesis, selanjutnya penyu- sunan historiografi atau laporan...

  18. 50 Years of synchrotrons Adams' Memorial lecture

    CERN Document Server

    Lawson, J D; CERN. Geneva

    1996-01-01

    Fifty years ago Frank Goward of the Atomic Energy Research Establishment Group at Malvern converted a small American betatron to make the worldÕs first synchrotron. At the same time Marcus Oliphant was planning to build at Birmingham a large proton machine with a ring magnet and variable magnetic field. Ideas for this had come to him during night-shifts tending the electromagnetic separators at Oak Ridge during the war. Some seven years later, in 1953, a group gathered together in Geneva to build the PS. A major contributor to the design work which had made this possible was John Adams. An account of some of the achievements in these eventful years will be presented. CERN has built nine synchrotrons/colliders and two temporary test rings. Eight machines are still running. The review will start with the PS, the first proton synchrotron based on the alternating gradient principle invented in 1952 at BNL. The design work of the PS team, under the enlightened leadership of J.B. Adams, and the construction of the...

  19. LEGEND, STORY AND NARRATION IN THE GENRE STRUCTURE OF IVAN SHMELEV'S SHORT NOVEL INEXHAUSTIBLE CUP: THE PROBLEM OF SOURCES

    Directory of Open Access Journals (Sweden)

    Nikolay Ivanovich Sobolev

    2013-11-01

    Full Text Available The article is devoted to one of the central episodes of Ivan Shmelev's short novel The Inexhaustible Chalice (Inexaustible Cup, or Non-intoxicating Chalice. The source of this episode was a legend, recorded by a priest Yakov Brilliantov. In 1912 he published the text of the legend calling it a Story of the Miraculous Icon of the Mother of God Called the “Inexhaustible Chalice”. The legend existed in the folk tradition for a long time. The paper presents a hypothesis that Ivan Shmelev reproduced an oral version or edition of the legend in his short novel. Comparison of Shmelev's novel and the old legend reveals similarities and discrepancies of texts, analysis of which can serve as the basis for important observations on lingvopoetics of the short novel and the author’s style. Ivan Shmelev uses the legend as a source of pious history: he connects it with his main text at all narrative levels, while leaving only functional elements in the recipient text. This type of creative editing can be defined as a form of a condensed narrative. Moreover, analysis of sources leads to a conclusion about the poetics of the chronotope and the main characters of the tale.

  20. Hurricane intensification along United States coast suppressed during active hurricane periods.

    Science.gov (United States)

    Kossin, James P

    2017-01-19

    The North Atlantic ocean/atmosphere environment exhibits pronounced interdecadal variability that is known to strongly modulate Atlantic hurricane activity. Variability in sea surface temperature (SST) is correlated with hurricane variability through its relationship with the genesis and thermodynamic potential intensity of hurricanes. Another key factor that governs the genesis and intensity of hurricanes is ambient environmental vertical wind shear (VWS). Warmer SSTs generally correlate with more frequent genesis and greater potential intensity, while VWS inhibits genesis and prevents any hurricanes that do form from reaching their potential intensity. When averaged over the main hurricane-development region in the Atlantic, SST and VWS co-vary inversely, so that the two factors act in concert to either enhance or inhibit basin-wide hurricane activity. Here I show, however, that conditions conducive to greater basin-wide Atlantic hurricane activity occur together with conditions for more probable weakening of hurricanes near the United States coast. Thus, the VWS and SST form a protective barrier along the United States coast during periods of heightened basin-wide hurricane activity. Conversely, during the most-recent period of basin-wide quiescence, hurricanes (and particularly major hurricanes) near the United States coast, although substantially less frequent, exhibited much greater variability in their rate of intensification, and were much more likely to intensify rapidly. Such heightened variability poses greater challenges to operational forecasting and, consequently, greater coastal risk during hurricane events.

  1. Hurricane damage assessment for residential construction considering the non-stationarity in hurricane intensity and frequency

    Institute of Scientific and Technical Information of China (English)

    WANG Cao; LI Quanwang; PANG Long; ZOU Aming; ZHANG Long

    2016-01-01

    Natural hazards such as hurricanes may cause extensive economic losses and social disruption for civil structures and infrastructures in coastal areas, implying the importance of understanding the construction performance subjected to hurricanes and assessing the hurricane damages properly. The intensity and frequency of hurricanes have been reported to change with time due to the potential impact of climate change. In this paper, a probability-based model of hurricane damage assessment for coastal constructions is proposed taking into account the non-stationarity in hurricane intensity and frequency. The non-homogeneous Poisson process is employed to model the non-stationarity in hurricane occurrence while the non-stationarity in hurricane intensity is reflected by the time-variant statistical parameters (e.g., mean value and/or standard deviation), with which the mean value and variation of the cumulative hurricane damage are evaluated explicitly. The Miami-Dade County, Florida, USA, is chosen to illustrate the hurricane damage assessment method proposed in this paper. The role of non-stationarity in hurricane intensity and occurrence rate due to climate change in hurricane damage is investigated using some representative changing patterns of hurricane parameters.

  2. Hurricane intensification along United States coast suppressed during active hurricane periods

    Science.gov (United States)

    Kossin, James P.

    2017-01-01

    The North Atlantic ocean/atmosphere environment exhibits pronounced interdecadal variability that is known to strongly modulate Atlantic hurricane activity. Variability in sea surface temperature (SST) is correlated with hurricane variability through its relationship with the genesis and thermodynamic potential intensity of hurricanes. Another key factor that governs the genesis and intensity of hurricanes is ambient environmental vertical wind shear (VWS). Warmer SSTs generally correlate with more frequent genesis and greater potential intensity, while VWS inhibits genesis and prevents any hurricanes that do form from reaching their potential intensity. When averaged over the main hurricane-development region in the Atlantic, SST and VWS co-vary inversely, so that the two factors act in concert to either enhance or inhibit basin-wide hurricane activity. Here I show, however, that conditions conducive to greater basin-wide Atlantic hurricane activity occur together with conditions for more probable weakening of hurricanes near the United States coast. Thus, the VWS and SST form a protective barrier along the United States coast during periods of heightened basin-wide hurricane activity. Conversely, during the most-recent period of basin-wide quiescence, hurricanes (and particularly major hurricanes) near the United States coast, although substantially less frequent, exhibited much greater variability in their rate of intensification, and were much more likely to intensify rapidly. Such heightened variability poses greater challenges to operational forecasting and, consequently, greater coastal risk during hurricane events.

  3. Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (sus domesticus spermatozoa during epididymal maturation

    Directory of Open Access Journals (Sweden)

    Bonet Sergi

    2011-06-01

    Full Text Available Abstract Fertilin alpha (ADAM-1 and beta (ADAM-2 are integral membrane proteins of the ADAM family that form a fertilin complex involved in key steps of the sperm-oocyte membrane interaction. In the present work, we analyzed the presence of ADAM-1 and ADAM-2 mRNAs, the spermatozoa proteins' processing and their sub-cellular localization in epididymal samples from adult boars. ADAM-1 and ADAM-2 mRNAs were highly produced in the testis, but also in the vas efferens and the epididymis. On immunoblots of sperm extracts, ADAM-1 subunit appeared as a main reactive band of ~50-55 kDa corresponding to occurrence of different isoforms throughout the epididymal duct, especially in the corpus region where isoforms ranged from acidic to basic pI. In contrast, ADAM-2 was detected as several bands of ~90 kDa, ~75 kDa, ~50-55 kDa and ~40 kDa. The intensity of high molecular mass bands decreased progressively in the distal corpus where lower bands were also transiently observed, and only the ~40 kDa was observed in the cauda. The presence of bands of different molecular weights likely results from a proteolytic processing occurring mainly in the testis for ADAM-1, and also throughout the caput epididymis for ADAM-2. Immunolocalization showed that fertilin migrates from the acrosomal region to the acrosomal ridge during the sperm transit from the distal corpus to the proximal cauda. This migration is accompanied by an important change in the extractability of a part of ADAM-1 from the sperm membrane. This suggests that the fertilin surface migration may be triggered by the biochemical changes induced by the epididymal post-translational processing of both ADAM1 and ADAM-2. Different patterns of fertilin immunolocalization then define several populations of spermatozoa in the cauda epididymis. Characterization of such fertilin complex maturation patterns is an important step to develop fertility markers based on epididymal maturation of surface membrane proteins

  4. 77 FR 64564 - Implementation of Regulatory Guide 1.221 on Design-Basis Hurricane and Hurricane Missiles

    Science.gov (United States)

    2012-10-22

    ... COMMISSION Implementation of Regulatory Guide 1.221 on Design-Basis Hurricane and Hurricane Missiles AGENCY....221 on Design-Basis Hurricane and Hurricane Missiles.'' The purpose of this ISG is to supplement the guidance regarding the application of Regulatory Guide 1.221, ``Design-Basis Hurricane and...

  5. A Disintegrin and Metalloproteinase10 (ADAM10 Regulates NOTCH Signaling during Early Retinal Development.

    Directory of Open Access Journals (Sweden)

    Joseph A Toonen

    Full Text Available ADAM10 and ADAM17 are two closely related members of the ADAM (a disintegrin and metalloprotease family of membrane-bound sheddases, which proteolytically cleave surface membrane proteins. Both ADAM10 and ADAM17 have been implicated in the proteolytic cleavage of NOTCH receptors and as such regulators of NOTCH signaling. During retinal development, NOTCH signaling facilitates retinal neurogenesis by maintaining progenitor cells in a proliferative state and by mediating retinal cell fates. However, the roles of ADAM10 and ADAM17 in the retina are not well defined. In this study, we set out to clarify the roles of ADAM10 and ADAM17 during early retinal development. The retinal phenotype of conditionally abated Adam17 retinae (Adam17 CKO did not differ from the controls whereas conditionally ablated Adam10 retinae (Adam10 CKO exhibited abnormal morphogenesis characterized by the formation of rosettes and a loss of retinal laminae phenotypically similar to morphological abnormalities identified in mice with retinal NOTCH signaling deficiency. Additionally, Adam10 CKO retinae exhibited abnormal neurogenesis characterized by fewer proliferating progenitor cells and greater differentiation of early photoreceptors and retinal ganglion cells. Moreover, constitutive activation of the NOTCH1-intracellular domain (N1-ICD rescued Adam10 CKO abnormal neurogenesis, as well as abnormal retinal morphology by maintaining retinal cells in the progenitor state. Collectively these findings provide in vivo genetic evidence that ADAM10, and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH signaling.

  6. A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development.

    Science.gov (United States)

    Toonen, Joseph A; Ronchetti, Adam; Sidjanin, D J

    2016-01-01

    ADAM10 and ADAM17 are two closely related members of the ADAM (a disintegrin and metalloprotease) family of membrane-bound sheddases, which proteolytically cleave surface membrane proteins. Both ADAM10 and ADAM17 have been implicated in the proteolytic cleavage of NOTCH receptors and as such regulators of NOTCH signaling. During retinal development, NOTCH signaling facilitates retinal neurogenesis by maintaining progenitor cells in a proliferative state and by mediating retinal cell fates. However, the roles of ADAM10 and ADAM17 in the retina are not well defined. In this study, we set out to clarify the roles of ADAM10 and ADAM17 during early retinal development. The retinal phenotype of conditionally abated Adam17 retinae (Adam17 CKO) did not differ from the controls whereas conditionally ablated Adam10 retinae (Adam10 CKO) exhibited abnormal morphogenesis characterized by the formation of rosettes and a loss of retinal laminae phenotypically similar to morphological abnormalities identified in mice with retinal NOTCH signaling deficiency. Additionally, Adam10 CKO retinae exhibited abnormal neurogenesis characterized by fewer proliferating progenitor cells and greater differentiation of early photoreceptors and retinal ganglion cells. Moreover, constitutive activation of the NOTCH1-intracellular domain (N1-ICD) rescued Adam10 CKO abnormal neurogenesis, as well as abnormal retinal morphology by maintaining retinal cells in the progenitor state. Collectively these findings provide in vivo genetic evidence that ADAM10, and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH signaling.

  7. Ivan Karamazov’s rebellion in Albert Camus’ and Karl Jaspers’ interpretations

    Directory of Open Access Journals (Sweden)

    Urszula Lisowska

    2010-12-01

    Full Text Available The aim of this study is to present Albert Camus’ and Karl Jaspers’ interpretations of Ivan Karamazov’s rebellion as the diagnoses of the weakness of the human intellect in confrontation with the world and the criticism of rationalism. Therefore, in the introduction I will present those fragments of the novel that characterize Ivan’s rebellion as highly abstract and theoretical. At the same time, this common literary context serves as the ground for reconstruction and comparison of the basic philosophical assumptions of each author. The intention of the remaining part of the paper is, firstly, to reconstruct A. Camus’ and K. Jaspers’ epistemology and, secondly, to analyse the arguments against Ivan’s attitude formulated by the writers. Their criticisms of the protagonist’s excessive trust in intellect is based on their own concepts of human epistemic capacity, which are related to the problems of the absurd in A. Camus’ and transcendence in K. Jaspers’ writings. The question of nihilism demands analysis of A. Camus’ idea of the nature of rebellion as both affirmative and negative, and of K. Jaspers’ notion of faith as pre-intellectual trust. Finally, their criticisms of the slogan “If there is no God, then anything is allowed” introduces the problem of freedom, which allows the comparison of the concepts of solidarity (A. Camus and communication (K. Jaspers. In the conclusion these two philosophical attitudes are discussed together. Keywords: ; ; ; ; ; ; ; ;

  8. ARTISTIC ADAPTATION OF THE ORIGINAL SOURCE IN THE ART WORKS BY IVAN SHMELEV

    Directory of Open Access Journals (Sweden)

    Nikolay Ivanovich Sobolev

    2014-11-01

    Full Text Available The article considers one of the aspects of artistic adaptation of an original source in the art works by Ivan Shmelev. The material of article is the story of the Abbot Damaskin, and the poetic text in the essays On the Rocks of Valaam and The Old Valaam, and folklore text in the tale Inexhaustible Cap. The analysis of the genesis of the formal structure of the quotes of diff erent levels at diff erent stages of the history of essays reveals the author's intention to recreate the Russian Orthodox world, to show examples of prime examples of ascetic life. To this end, the author transforms the text of the Early edition, leaving only those fragments that create images of Holiness. In the Later edition of the concise description, the author uses a reportage style. He accurately reproduces the discoerse of the monks. Analysis of the specificity of adaptation wedding ritual songs in the narrative structure of the novel shows that the author changes the value of the folklore text. Creates a parallel of the ecclesiastical and the folk, refl ecting the ethno-religious attitude of the main character. Author`s intention is to see and understand the Christian soul of the Russian people.

  9. Ivan Djaja (Jean Giaja)1 and the Belgrade School of Physiology

    Science.gov (United States)

    Andjus, Pavle R.; Stojilkovic, Stanko S.; Cvijic, Gordana

    2016-01-01

    Summary The founder of physiology studies in the Balkans and the pioneer of research on hypothermia, Ivan Djaja (Jean Giaja) was born 1884 in L’Havre. Giaja gained his PhD at the Sorbonne in 1909. In 1910 he established the first Chair of Physiology in the Balkans and organized the first Serbian Institute for Physiology at the School of Philosophy of the University of Belgrade. He led this Institute for more than 40 subsequent years. His most notable papers were in the field of thermoregulation and bioenergetics. Djaja became member of the Serbian and Croatian academies of science and doctor honoris causa of Sorbonne. In 1952 for the seminal work on the behaviour of deep cooled warm blooded animals he becane associate member of the National Medical Academy in Paris. In 1955 the French Academy of Sciences elected him as associate member in place of deceased Sir Alexander Fleming. Djaja died in 1957 during a congress held in his honour. He left more than 200 scientific and other papers and the golden DaVincian credo “Nulla dies sine experimento”. His legacy was continued by several generations of researchers, the most prominent among them being Stefan Gelineo, Radoslav Andjus and Vojislav Petrović. PMID:21777022

  10. A segunda crítica social da Saúde de Ivan Illich

    Directory of Open Access Journals (Sweden)

    Roberto Passos Nogueira

    2003-02-01

    Full Text Available Na Nêmesis da Medicina, Ivan Illich expôs os elementos essenciais da sua primeira crítica da saúde, afirmando que a ampla industrialização da saúde e medicalização da vida na sociedade moderna faz aparecer diversas formas de iatrogênese ou danos à saúde, como resultado da perda da capacidade de ação autônoma das pessoas perante a enfermidade, a dor e o envelhecimento. Na segunda crítica social da saúde, Illich trata do surgimento de uma nova iatrogênese social, a iatrogênese do corpo, que resulta de uma espécie de obsessão com a saúde corporal e com sua produção através de atividades físicas, dietas etc. em aparente condição de autonomia. Trata-se de um consumismo do corpo saudável, que responde menos à ação dos médicos e mais às informações difundidas pelos meios de comunicação e pelos agentes terapêuticos não-oficiais.

  11. Slovene poetry in the U.S.A.: the case of Ivan Zorman

    Directory of Open Access Journals (Sweden)

    Igor Maver

    1999-12-01

    Full Text Available Ivan Zorman was both a musician and a poet, born in 1889 in Šmarje near Grosuplje and died in 1957 in Cleveland (Ohio. In 1893 his family emigrated to the United States of America, first to Ely, Calumet, Cleveland and then to some other American towns. After a brief return to Slovenia in 1898/9, where Zorman attended elementary school in Velesovo near Kranj, they finally settled down in 1904 in Cleveland. In 1907 Zorman took up the study of modern languages (English, French and Italian, history and music at Western Reserve University and graduated only in music in 1912. For a number of years, during 1908 and 1956, he was chief organist and choir leader (like his father at the parish church of Sv. Lovrenc in Newburgh near Cleveland. During 1920 and 1925 he was professional director of the "Zorman Philharmonic". Not only was he known as a musician, he was very much present in the public life of the Slovene community living in Cleveland, as the enthusiastic teacher of Slovene literature in the Slovene school of the "Slovenski narodni dom", as a poet, translator and public speaker.

  12. The industrialization of fetishism or the fetishism of industrialization: a critique of Ivan Illich.

    Science.gov (United States)

    Navarro, V

    1975-01-01

    This article critically assesses the ideology of industrialism in light of Ivan Illich's Medical Nemesis. The paper is divided into three sections. The first section is a description of the main features of that ideology, the most prevalent and influential one used in sociological literature to explain the state both of Western societies and of our health services. Also in this section, it is shown how these features appear in Illich's analysis of our societies, of our health services, and of the different clinical, social, and structural iatrogeneses that health services create. The second section examines the assumptions underlying Illich's analysis and discusses their validity to explain the nature and function of our Western health services and their iatrogenic effects. Where Illich's explanations are considered invalid, alternative explanations are presented. Among them, it is postulated that it is not industrialism, but the assumedly transcended category of capitalism that is the cause of the social and structural iatrogeneses. The third section discusses the political implications of Illich's analysis, in a moment when our Western societies are supposedly in crisis.

  13. The politics of physiological psychology. Ivan Pavlov's suppressed defense of scientific freedom and its consequences.

    Science.gov (United States)

    Horowitz, I L

    1993-01-01

    This statement, first presented at a plenary session of the Pavlovian Society on 9 October 1992, in Los Angeles, California, attempts to assess the recently released speech delivered by Ivan Pavlov in 1923, but publicly brought to light only in 1991, on the subject of "Communist Dogmatism and the Autonomy of Science." This speech, noteworthy for the courage of the delivery under adverse circumstances no less than the contents of its remarks, compels a new estimate of the place of science in a totalitarian system boasting an ideology of physiological psychology. It also sheds new light on the Russian Nobel laureate and pioneer in the areas of behavior modification induced by the functions of the higher nervous system. These remarks take an in-depth view of American radical and Marxian appraisals--how they followed the Soviet lead in harnessing Pavlov to the Communist cause, and in attempting to discredit the work of Sigmund Freud. This lethal combination of Communist political needs and ideological proclivities served to rationalize the implementation of slave labor as work therapy during the Stalinist era. The linkage of Pavlov to Makarenko in education and Michurin in biology serves as a case study in the manufacture of tradition. The collapse of the Soviet system permits a recasting of the history of science and Pavlov's place in Russian life. Such new conditions also provide a lesson in the distortive role of ideology in the evolution of modern science.

  14. John Adams and CERN: Personal Recollections

    CERN Document Server

    Brianti, Giorgio

    2013-01-01

    By any standards, John Adams had a most remarkable career. He was involved in three important, emerging technologies, radar, particle accelerators and controlled fusion, and had an outstanding impact on the last two. Without a university education, he attained hierarchical positions of the highest level in prestigious national and international organizations. This article covers the CERN part of his career, by offering some personal insights into the different facets of his contributions to major accelerator projects, from the first strong-focusing synchrotron, the PS, to the SPS and its conversion to a proton–antiproton collider. In particular, it outlines his abilities as a leader of an international collaboration, which has served as an example for international initiatives in other disciplines.

  15. Adam Smith on public expenditure and taxation

    Directory of Open Access Journals (Sweden)

    Maurício C. Coutinho

    2009-05-01

    Full Text Available This paper presents Adam Smith’s view on taxation and public expenditure, by means of an almost literal reading of the Wealth of Nations famous passages on the “duties of the sovereign” and on the “maxims of taxation”. Contrarily to the commonest usage of these passages, we will show that their core is the preoccupation with the public expenditure soaring and the defence of decentralisation. Furthermore – and also contrarily to the existing interpretations – we defend the non-existence of any contradiction between Smith’s income and price theory (and the incidence hypothesis, provided due attention is paid to the guiding role of the “maxims”.

  16. Luhmann Receives 2007 John Adam Fleming Medal

    Science.gov (United States)

    Russell, Christopher T.; Luhmann, Janet G.

    2008-02-01

    This year's John Adam Fleming medalist quickly established a reputation as an innovative and productive scientist with a broad range of interests. She made early and seminal contributions to aeronomy, cosmic rays, and magnetospheric and planetary physics. She contributed importantly to the understanding of the interaction of the solar wind with the atmosphere and magnetic fields of Mercury, Venus, Earth, and Mars. She has examined the behavior of planetary rings, the interaction of interstellar neutrals with heliospheric plasmas, as well as the interaction of planetary neutrals with the heliosphere. She has led in the study of the interaction of the moon Titan with the Saturn magnetosphere, and most recently she developed a vigorous solar physics effort, leading the implementation of the IMPACT particle and field package on the twin STEREO mission, now entering its second year of successful operation.

  17. Hurricane Footprints in Global Climate Models

    Directory of Open Access Journals (Sweden)

    Francisco J. Tapiador

    2008-11-01

    Full Text Available This paper addresses the identification of hurricanes in low-resolution global climate models (GCM. As hurricanes are not fully resolvable at the coarse resolution of the GCMs (typically 2.5 × 2.5 deg, indirect methods such as analyzing the environmental conditions favoring hurricane formation have to be sought. Nonetheless, the dynamical cores of the models have limitations in simulating hurricane formation, which is a far from fully understood process. Here, it is shown that variations in the specific entropy rather than in dynamical variables can be used as a proxy of the hurricane intensity as estimated by the Accumulated Cyclone Energy (ACE. The main application of this research is to ascertain the changes in the hurricane frequency and intensity in future climates.

  18. The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice

    Directory of Open Access Journals (Sweden)

    Lakshini Herat

    2017-04-01

    Full Text Available Obesity and diabetes are major causes of morbidity and mortality globally. The current study builds upon our previous association studies highlighting that A Disintegrin And Metalloproteinase 28 (ADAM28 appears to be implicated in the pathogenesis of obesity and type 2 diabetes in humans. Our novel study characterised the expression of ADAM28 in mice with the metabolic syndrome and used molecular inhibition approaches to investigate the functional role of ADAM28 in the pathogenesis of high fat diet-induced obesity. We identified that ADAM28 mRNA and protein expression was markedly increased in the livers of mice with the metabolic syndrome. In addition, noradrenaline, the major neurotransmitter of the sympathetic nervous system, results in elevated Adam28 mRNA expression in human monocytes. Downregulation of ADAM28 with siRNA technology resulted in a lack of weight gain, promotion of insulin sensitivity/glucose tolerance and decreased liver tumour necrosis factor-α (TNF-α levels in our diet-induced obesity mouse model as well as reduced blood urea nitrogen, alkaline phosphatase and aspartate aminotransferase. In addition, we show that ADAM28 knock-out mice also displayed reduced body weight, elevated high density lipoprotein cholesterol levels, and reductions in blood urea nitrogen, alkaline phosphatase, and aspartate aminotransferase. The results of this study provide important insights into the pathogenic role of the metalloproteinase ADAM28 in the metabolic syndrome and suggests that downregulation of ADAM28 may be a potential therapeutic strategy in the metabolic syndrome.

  19. The great Louisiana hurricane of August 1812

    OpenAIRE

    Mock, Cary J.; Chenoweth, Michael; Altamirano, Isabel; Rodgers, Matthew D.; García Herrera, Ricardo

    2010-01-01

    Major hurricanes are prominent meteorological hazards of the U.S. Atlantic and Gulf coasts. However, the official modern record of Atlantic basin tropical cyclones starts at 1851, and it does not provide a comprehensive measure of the frequency and magnitude of major hurricanes. Vast amounts of documentary weather data extend back several centuries, but many of these have not yet been fully utilized for hurricane reconstruction. These sources include weather diaries, ship logbooks, ship prote...

  20. The Roles of ADAMs Family Proteinases in Skin Diseases

    Directory of Open Access Journals (Sweden)

    Masakazu Kawaguchi

    2011-01-01

    Full Text Available A disintegrin and metalloproteinases (ADAMs are members of a new gene family of transmembrane and secreted proteins, which belong to the zinc proteinase superfamily. These molecules are involved in various biological events such as cell adhesion, cell fusion, cell migration, membrane protein shedding, and proteolysis. Growing evidence now attests to the potential involvement of ADAMs proteinases in diverse processes such as skin wound healing, inflammation, pigmentation, tumor development, cell proliferation, and metastasis. This paper focuses on the roles of ADAMs proteinases in a wide variety of skin diseases.

  1. Human ADAM 12 (meltrin alpha) is an active metalloprotease

    DEFF Research Database (Denmark)

    Loechel, F; Gilpin, B J; Engvall, E

    1998-01-01

    in a latent form, probably by means of a cysteine switch. The zymogen could be activated chemically by alkylation with N-ethylmaleimide. Cleavage of the prodomain at a site for a furin-like endopeptidase resulted in an ADAM 12 protein with proteolytic activity. The protease activity was sensitive...... 12 is catalytically active. We used the trapping mechanism of alpha2-macroglobulin to assay for protease activity of wild-type and mutant ADAM 12 proteins produced in a COS cell transfection system. We found that ADAM 12 is synthesized as a zymogen, with the prodomain maintaining the metalloprotease...

  2. Research on Goods and the Ship Interaction Based on ADAMS

    Directory of Open Access Journals (Sweden)

    Song Fangzhen

    2017-01-01

    Full Text Available The equivalent method of the relative movement goods on board is discussed in details. This method is to establish dynamic model based on moving trajectory of gravity-center for goods and to take rigid body geometric model with the trajectory as constraints in ADAMS. The difference of simulation methods for the different goods in carrier rolling is compared. The interact of relative moving objects with bulk carrier is discussed by using the ADAMS model. It is verified that the ballast water can maintain the ship’s stability by means of the ADAMS model.

  3. Molecular profiling of ADAM12 in human bladder cancer

    DEFF Research Database (Denmark)

    Frolich, Camilla; Albrechtsen, Reidar; Andersen, Lars Dyrskjøt

    2006-01-01

    PURPOSE: We have previously found ADAM12, a disintegrin and metalloprotease, to be an interesting biomarker for breast cancer. The purpose of this study was to determine the gene and protein expression profiles of ADAM12 in different grades and stages of bladder cancer. EXPERIMENTAL DESIGN: ADAM12...... gene expression was evaluated in tumors from 96 patients with bladder cancer using a customized Affymetrix GeneChip. Gene expression in bladder cancer was validated using reverse transcription-PCR, quantitative PCR, and in situ hybridization. Protein expression was evaluated by immunohistochemical...

  4. Hurricane Excitation of Earth Eigenmodes

    OpenAIRE

    Peters, Randall D.

    2005-01-01

    A non-conventional vertical seismometer, with good low-frequency sensitivity, was used to study earth motions in Macon, Georgia USA during the time of hurricane Charley, August 2004. During its transitions between water and land, the powerful storm showed an interesting history of microseisms and also generated more than half-a-dozen surprisingly coherent oscillations, whose frequencies ranged from 0.9 to 3 mHz.

  5. Hurricane Boundary-Layer Theory

    Science.gov (United States)

    2010-01-01

    2501. Kundu PK. 1990. Fluid Mechanics . Academic Press: San Diego, USA. Kuo HL. 1982. Vortex boundary layer under quadratic surface stress. Boundary...identification of two mechanisms for the spin-up of the mean tangential circulation of a hurricane. The first involves convergence of absolute angular...momentum above the boundary layer, where this quantity is approximately conserved. This mechanism acts to spin up the outer circulation at radii

  6. Lessons Learnt From Hurricane Katrina.

    Science.gov (United States)

    Akundi, Murty

    2008-03-01

    Hurricane Katrina devastated New Orleans and its suburbs on Monday August 29^th, 2005. The previous Friday morning, August 26, the National Hurricane Center indicated that Katrina was a Category One Hurricane, which was expected to hit Florida. By Friday afternoon, it had changed its course, and neither the city nor Xavier University was prepared for this unexpected turn in the hurricane's path. The university had 6 to 7 ft of water in every building and Xavier was closed for four months. Students and university personnel that were unable to evacuate were trapped on campus and transportation out of the city became a logistical nightmare. Email and all electronic systems were unavailable for at least a month, and all cell phones with a 504 area code stopped working. For the Department, the most immediate problem was locating faculty and students. Xavier created a list of faculty and their new email addresses and began coordinating with faculty. Xavier created a web page with advice for students, and the chair of the department created a separate blog with contact information for students. The early lack of a clear method of communication made worse the confusion and dismay among the faculty on such issues as when the university would reopen, whether the faculty would be retained, whether they should seek temporary (or permanent) employment elsewhere, etc. With the vision and determination of President Dr. Francis, Xavier was able to reopen the university in January and ran a full academic year from January through August. Since Katrina, the university has asked every department and unit to prepare emergency preparedness plans. Each department has been asked to collect e-mail addresses (non-Xavier), cell phone numbers and out of town contact information. The University also established an emergency website to communicate. All faculty have been asked to prepare to teach classes electronically via Black board or the web. Questions remain about the longer term issues of

  7. ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Ungerer, Christopher; Doberstein, Kai [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany); Buerger, Claudia; Hardt, Katja; Boehncke, Wolf-Henning [Department of Dermatology, Clinic of the Goethe-University, Theodor-Stern-Kai, Frankfurt (Germany); Boehm, Beate [Division of Rheumatology, Goethe University, Frankfurt am Main (Germany); Pfeilschifter, Josef [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany); Dummer, Reinhard [Department of Pathology, Institute of Surgical Pathology, University Hospital, Zurich (Switzerland); Mihic-Probst, Daniela [Department of Dermatology, University Hospital Zurich (Switzerland); Gutwein, Paul, E-mail: p.gutwein@med.uni-frankfurt.de [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany)

    2010-10-22

    Research highlights: {yields} Strong ADAM15 expression is found in normal melanocytes. {yields} ADAM15 expression is significantly downregulated in patients with melanoma metastasis. {yields} TGF-{beta} can downregulate ADAM15 expression in melanoma cells. {yields} Overexpression of ADAM15 in melanoma cells inhibits migration, proliferation and invasion of melanoma cells. {yields} Conclusion: ADAM15 represents an tumor suppressor protein in melanoma. -- Abstract: In a mouse melanoma metastasis model it has been recently shown that ADAM15 overexpression in melanoma cells significantly reduced the number of metastatic nodules on the lung. Unfortunately, the expression of ADAM15 in human melanoma tissue has not been determined so far. In our study, we characterized the expression of ADAM15 in tissue micro-arrays of patients with primary melanoma with melanoma metastasis. ADAM15 was expressed in melanocytes and endothelial cells of benign nevi and melanoma tissue. Importantly, ADAM15 was significantly downregulated in melanoma metastasis compared to primary melanoma. We further demonstrate that IFN-{gamma} and TGF-{beta} downregulate ADAM15 protein levels in melanoma cells. To investigate the role of ADAM15 in melanoma progression, we overexpressed ADAM15 in melanoma cells. Importantly, overexpression of ADAM15 in melanoma cells reduced the migration, invasion and the anchorage dependent and independent cell growth of melanoma cells. In summary, the downregulation of ADAM15 plays an important role in melanoma progression and ADAM15 act as a tumorsuppressor in melanoma.

  8. A substrate-optimized electrophoretic mobility shift assay for ADAM12

    DEFF Research Database (Denmark)

    Kotzsch, Alexander; Skovgaard, Tine; Buus, Uwe

    2014-01-01

    ADAM12 belongs to the A disintegrin and metalloprotease (ADAM) family of secreted sheddases activating extracellular growth factors such as epidermal growth factor receptor (EGFR) ligands and tumor necrosis factor-alpha (TNF-α). ADAM proteases, most notably ADAM17 (TNF-α-converting enzyme), have...

  9. Dynamic Hurricane Data Analysis Tool

    Science.gov (United States)

    Knosp, Brian W.; Li, Peggy; Vu, Quoc A.

    2009-01-01

    A dynamic hurricane data analysis tool allows users of the JPL Tropical Cyclone Information System (TCIS) to analyze data over a Web medium. The TCIS software is described in the previous article, Tropical Cyclone Information System (TCIS) (NPO-45748). This tool interfaces with the TCIS database to pull in data from several different atmospheric and oceanic data sets, both observed by instruments. Users can use this information to generate histograms, maps, and profile plots for specific storms. The tool also displays statistical values for the user-selected parameter for the mean, standard deviation, median, minimum, and maximum values. There is little wait time, allowing for fast data plots over date and spatial ranges. Users may also zoom-in for a closer look at a particular spatial range. This is version 1 of the software. Researchers will use the data and tools on the TCIS to understand hurricane processes, improve hurricane forecast models and identify what types of measurements the next generation of instruments will need to collect.

  10. 2004 Pre-Hurricane Ivan Eastern Gulf Coast United States Army Corps of Engineers (USACE) Lidar-Derived Dune Crest, Toe and Shoreline

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Storm-Induced Coastal Change Hazards component of the National Assessment of Coastal Change Hazards project focuses on understanding the magnitude and...

  11. African Dust Influence on Atlantic Hurricane Activity and the Peculiar Behaviour of Category 5 Hurricanes

    CERN Document Server

    Herrera, Victor M Velasco; H., Graciela Velasco; Gonzalez, Laura Luna

    2010-01-01

    We study the specific influence of African dust on each one of the categories of Atlantic hurricanes. By applying wavelet analysis, we find a strong decadal modulation of African dust on Category 5 hurricanes and an annual modulation on all other categories of hurricanes. We identify the formation of Category 5 hurricanes occurring mainly around the decadal minimum variation of African dust and in deep water areas of the Atlantic Ocean, where hurricane eyes have the lowest pressure. According to our results, future tropical cyclones will not evolve to Category 5 until the next decadal minimum that is, by the year 2015 +/- 2.

  12. Changes in intraocular pressure in study and fellow eyes in the IVAN trial

    Science.gov (United States)

    Foss, Alexander J E; Scott, Lauren J; Rogers, Chris A; Reeves, Barney C; Ghanchi, Faruque; Gibson, Jonathan; Chakravarthy, Usha

    2016-01-01

    Purpose To describe changes in intraocular pressure (IOP) in the ‘alternative treatments to Inhibit VEGF in Age-related choroidal Neovascularisation (IVAN)’ trial (registered as ISRCTN92166560). Design Randomised controlled clinical trial with factorial design. Participants Patients (n=610) with treatment naïve neovascular age-related macular degeneration were enrolled and randomly assigned to receive either ranibizumab or bevacizumab and to two regimens, namely monthly (continuous) or as needed (discontinuous) treatment. Methods At monthly visits, IOP was measured preinjection in both eyes, and postinjection in the study eye. Outcome measures The effects of 10 prespecified covariates on preinjection IOP, change in IOP (postinjection minus preinjection) and the difference in preinjection IOP between the two eyes were examined. Results For every month in trial, there was a statistically significant rise in both the preinjection IOP and the change in IOP postinjection during the time in the trial (estimate 0.02 mm Hg, 95% CI 0.01 to 0.03, p<0.001 and 0.03 mm Hg, 95% CI 0.01 to 0.04, p=0.002, respectively). There was also a small but significant increase during the time in trial in the difference in IOP between the two eyes (estimate 0.01 mm Hg, 95% CI 0.005 to 0.02, p<0.001). There were no differences between bevacizumab and ranibizumab for any of the three outcomes (p=0.93, p=0.22 and p=0.87, respectively). Conclusions Anti-vascular endothelial growth factor agents induce increases in IOP of small and uncertain clinical significance. Trial registration number ISRCTN92166560. PMID:27073205

  13. ADAM 12 protease induces adipogenesis in transgenic mice

    DEFF Research Database (Denmark)

    Kawaguchi, Nobuko; Xu, Xiufeng; Tajima, Rie

    2002-01-01

    in the perivascular space in muscle tissue of 1- to 2-week-old transgenic mice whereas mature lipid-laden adipocytes were seen at 3 to 4 weeks. Moreover, female transgenics expressing ADAM 12-S exhibited increases in body weight, total body fat mass, abdominal fat mass, and herniation, but were normoglycemic and did......-anchored protein, ADAM 12-L, and a shorter secreted form, ADAM 12-S. Here we report the occurrence of adipocytes in the skeletal muscle of transgenic mice in which overexpression of either form is driven by the muscle creatine kinase promoter. Cells expressing a marker of early adipogenesis were apparent...... not exhibit increased serum insulin, cholesterol, or triglycerides. Male transgenics were slightly overweight and also developed herniation but did not become obese. Transgenic mice expressing a truncated form of ADAM 12-S lacking the prodomain and the metalloprotease domain did not develop this adipogenic...

  14. Association of ADAM33 gene polymorphisms with allergic asthma

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Zand Karimi

    2014-09-01

    Conclusion: Polymorphisms of ADAM33 gene might be associated with severe asthma and sensitivity to aeroallergens in northeast of Iran, but further studies are needed to determine the polymorphisms in this area and other regions of our country.

  15. ADAM-15 Disintegrin-Like Domain Structure and Function

    Directory of Open Access Journals (Sweden)

    Dong Lu

    2010-10-01

    Full Text Available The ADAM (a disintegrin-like and metalloproteinase proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integrin binding motif Arg-Gly-Asp (RGD in its disintegrin-like domain. This motif is also found in most snake venom disintegrins and other disintegrin-like proteins. This unique RGD motif within ADAM-15 serves as an integrin ligand binding site, through which it plays a pivotal role in interacting with integrin receptors, a large family of heterodimeric transmembrane glycoproteins. This manuscript will present a review of the RGD-containing disintegrin-like domain structures and the structural features responsible for their activity as antagonists of integrin function in relation to the canonical RGD template.

  16. Adam Podin ja pan-evangeelne vaimulaad / Toivo Pilli

    Index Scriptorium Estoniae

    Pilli, Toivo, 1962-

    2013-01-01

    Adam Podini elust ja tööst: Keila baptistikoguduse vaimulikuna, vanglamisjonäri ja pidalitõbiste abistajana, baptistide teoloogilise seminari direktorina, Evangeelse Alliansi kontaktisikuna Eestis

  17. Sherali-Adams Relaxations of Graph Isomorphism Polytopes

    CERN Document Server

    Malkin, Peter N

    2011-01-01

    We investigate the Sherali-Adams lift & project hierarchy applied to a graph isomorphism polytope whose integer points encode the isomorphisms between two graphs. In particular, the Sherali-Adams relaxations characterize a new vertex classification algorithm for graph isomorphism, which we call the generalized vertex classification algorithm. This algorithm generalizes the classic vertex classification algorithm and generalizes the work of Tinhofer on polyhedral methods for graph automorphism testing. We establish that the Sherali-Adams lift & project hierarchy when applied to a graph isomorphism polytope needs Omega(n) iterations in the worst case before converging to the convex hull of integer points. We also show that this generalized vertex classification algorithm is also strongly related to the well-known Weisfeiler-Lehman algorithm, which we show can also be characterized in terms of the Sherali-Adams relaxations of a semi-algebraic set whose integer points encode graph isomorphisms.

  18. Siim Nestor soovitab : Ugly Duckling. Adam F / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2006-01-01

    Ameerika hip-hop-ansambli Ugly Duckling'i heliplaadi "Bang for the Buck"esitluskontserdist 9. nov. Tallinna klubis Hollywood. Inglise diskor Adam F drum'n'bass-üritusel "Sin City" 10. nov. Tartu linna klubis Tallinn

  19. Siim Nestor soovitab : Ugly Duckling. Adam F / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2006-01-01

    Ameerika hip-hop-ansambli Ugly Duckling'i heliplaadi "Bang for the Buck"esitluskontserdist 9. nov. Tallinna klubis Hollywood. Inglise diskor Adam F drum'n'bass-üritusel "Sin City" 10. nov. Tartu linna klubis Tallinn

  20. Adam Podin ja pan-evangeelne vaimulaad / Toivo Pilli

    Index Scriptorium Estoniae

    Pilli, Toivo, 1962-

    2013-01-01

    Adam Podini elust ja tööst: Keila baptistikoguduse vaimulikuna, vanglamisjonäri ja pidalitõbiste abistajana, baptistide teoloogilise seminari direktorina, Evangeelse Alliansi kontaktisikuna Eestis

  1. Mazungumzo na Adam Shafi juu ya uandishi wake wa riwaya

    OpenAIRE

    Diegner, Lutz; Shafi, Adam

    2012-01-01

    Adam Shafi aliyezaliwa mwaka 1940 kisiwani Unguja ni mmojawapo wa waandishi mashuhuri wa riwaya ya Kiswahili. Hivi sasa mwandishi yumo mbioni kukamilisha muswada wa riwaya yake ya sita iitwayo Mtoto wa Mama. Mbali na uandishi, Adam Shafi aliwahi kufanya kazi mbalimbali za uandishi wa habari na kazi za ushirika wa kimataifa. Ni furaha yetu kubwa kuwa hatimaye tunaweza kutoa mazungumzo hayo baada ya kuyapitia na kuyahariri kidogo tu, kwa vile tunaamini utamu wa lugha inavyozungumzwa katika hali...

  2. John of Salisbury, Adam of Balsham and The Cornifician Problem

    DEFF Research Database (Denmark)

    Bloch, David

    2010-01-01

    En undersøgelse af den Cornificius, som John of Salisbury angriber i sit værk Metalogicon. Der argumenteres for, at Cornificius er åbenlyst inspireret af den berømte Adam of Balsham......En undersøgelse af den Cornificius, som John of Salisbury angriber i sit værk Metalogicon. Der argumenteres for, at Cornificius er åbenlyst inspireret af den berømte Adam of Balsham...

  3. Sexual selection and the molecular evolution of ADAM proteins.

    Science.gov (United States)

    Finn, Scott; Civetta, Alberto

    2010-09-01

    Rapid evolution has been identified for many reproductive genes and recent studies have combined phylogenetic tests and information on species mating systems to test sexual selection. Here we examined the molecular evolution of the ADAM gene family, a diverse group of 35 proteins capable of adhesion to and cleavage of other proteins, using sequence data from 25 mammalian genes. Out of the 25 genes analyzed, all those expressed in male reproductive tissue showed evidence of positive selection. Positively selected amino acids within the protein adhesion domain were only found in sperm surface ADAM proteins (ADAMs 1, 2, 3, 4, and 32) suggesting selection driven by male x female interactions. We tested heterogeneity in rates of evolution of the adhesion domain of ADAM proteins by using sequence data from Hominidae and macaques. The use of the branch and branch-site models (PAML) showed evidence of higher d (N)/d (S) and/or positive selection linked to branches experiencing high postmating selective pressures (chimpanzee and macaque) for Adams 2, 18, and 23. Moreover, we found consistent higher proportion of nonsynonymous relative to synonymous and noncoding sequence substitutions in chimpanzee and/or macaque only for Adams 2, 18, and 23. Our results suggest that lineage-specific sexual selection bouts might have driven the evolution of the adhesion sperm protein surface domains of ADAMs 2 and 18 in primates. Adams 2 and 18 are localized in chromosome 8 of primates and adjacent to each other, so their evolution might have also been influenced by their common genome localization.

  4. ADAM10 as a target for anti-cancer therapy.

    Science.gov (United States)

    Moss, Marcia L; Stoeck, Alexander; Yan, Wenbo; Dempsey, Peter J

    2008-02-01

    There is a great unmet medical need in the area of cancer treatment. A potential therapeutic target for intervention in cancer is ADAM10. ADAM10 is a disintegrin-metalloproteinase that processes membrane bound proteins from the cell surface to yield soluble forms. Pharmaceutical companies are actively seeking out inhibitors of ADAM10 for treatments in cancer as the enzyme is known to release the ErbB receptor, HER2/ErbB2 from the cell membrane, an event that is necessary for HER2 positive tumor cells to proliferate. ADAM10 is also capable of processing betacellulin indicating that an inhibitor could be used against EGFR/ErbB1 and/or HER4/ErbB4 receptor positive tumor cells that are betacellulin-dependent. ADAM10 is the principle sheddase for several other molecules associated with cancer proliferation, differentiation, adhesion and migration such as Notch, E-cadherin, CD44 and L1 adhesion molecule indicating that targeting ADAM10 with specific inhibitors could be beneficial.

  5. Two-dimensional time dependent hurricane overwash and erosion modeling at Santa Rosa Island

    Science.gov (United States)

    McCall, R.T.; Van Theil de Vries, J. S. M.; Plant, N.G.; Van Dongeren, A. R.; Roelvink, J.A.; Thompson, D.M.; Reniers, A.J.H.M.

    2010-01-01

    A 2DH numerical, model which is capable of computing nearshore circulation and morphodynamics, including dune erosion, breaching and overwash, is used to simulate overwash caused by Hurricane Ivan (2004) on a barrier island. The model is forced using parametric wave and surge time series based on field data and large-scale numerical model results. The model predicted beach face and dune erosion reasonably well as well as the development of washover fans. Furthermore, the model demonstrated considerable quantitative skill (upwards of 66% of variance explained, maximum bias - 0.21 m) in hindcasting the post-storm shape and elevation of the subaerial barrier island when a sheet flow sediment transport limiter was applied. The prediction skill ranged between 0.66 and 0.77 in a series of sensitivity tests in which several hydraulic forcing parameters were varied. The sensitivity studies showed that the variations in the incident wave height and wave period affected the entire simulated island morphology while variations in the surge level gradient between the ocean and back barrier bay affected the amount of deposition on the back barrier and in the back barrier bay. The model sensitivity to the sheet flow sediment transport limiter, which served as a proxy for unknown factors controlling the resistance to erosion, was significantly greater than the sensitivity to the hydraulic forcing parameters. If no limiter was applied the simulated morphological response of the barrier island was an order of magnitude greater than the measured morphological response.

  6. Modeling lost production from destroyed platforms in the 2004-2005 Gulf of Mexico hurricane seasons

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, Mark J.; Yu, Yunke [Center for Energy Studies, Louisiana State University, Energy Coast and Environment Building, Nicholson Extension Drive, Baton Rouge, LA 70803 (United States); Jablonowski, Christopher J. [Department of Petroleum and Geosystems Engineering, The University of Texas at Austin, 1 University Station C0300, Austin, TX 78712-0228 (United States)

    2009-09-15

    Hurricanes Ivan, Katrina, and Rita passed through the Gulf of Mexico during 2004 and 2005 and resulted in the largest number of destroyed and damaged offshore oil and gas structures in the history of Gulf operations. In the final official government assessment, a total of 126 platforms were destroyed and over 183 structures were identified as having extensive damage. Production associated with wells and structures that are not redeveloped are classified as lost. The purpose of this paper is to derive functional relations that describe the likely contribution the collection of destroyed assets would have made to future production in the Gulf of Mexico. We estimate that the total remaining reserves from the set of destroyed structures range in value between 1.3 and 4.5 billion depending on the assumptions employed. We summarize the impact of the storms on the Gulf of Mexico oil and gas infrastructure and discuss the main issues involved in redevelopment decision making. A meta-model analytic framework is applied to perform sensitivity analysis and to explore the interactions of assumptions on model output. A discussion of the limitations of the analysis is presented. (author)

  7. Catherine Merridale, Ivan's War, the Red Army 1939-1945, London: Faber and Faber, 2005, 396 pages.

    Directory of Open Access Journals (Sweden)

    Joris Van Bladel

    2006-11-01

    Full Text Available Catherine Merridale's first well reviewed and much appraised book “Night of Stone, Death and Memory in Russia” (Granta, 2000  examined the culture of suffering in Russia during the Soviet period. One key chapter in this previous book detailed the ordeals undergone by the Russian Armed Forces and the people at large, during the Great Patriotic War. Five years later, the British historian brings her expertise to this topic in  Ivan's War.At first glance, the topic of suffering and endurance of...

  8. Increased Accuracy in Statistical Seasonal Hurricane Forecasting

    Science.gov (United States)

    Nateghi, R.; Quiring, S. M.; Guikema, S. D.

    2012-12-01

    Hurricanes are among the costliest and most destructive natural hazards in the U.S. Accurate hurricane forecasts are crucial to optimal preparedness and mitigation decisions in the U.S. where 50 percent of the population lives within 50 miles of the coast. We developed a flexible statistical approach to forecast annual number of hurricanes in the Atlantic region during the hurricane season. Our model is based on the method of Random Forest and captures the complex relationship between hurricane activity and climatic conditions through careful variable selection, model testing and validation. We used the National Hurricane Center's Best Track hurricane data from 1949-2011 and sixty-one candidate climate descriptors to develop our model. The model includes information prior to the hurricane season, i.e., from the last three months of the previous year (Oct. through Dec.) and the first five months of the current year (January through May). Our forecast errors are substantially lower than other leading forecasts such as that of the National Oceanic and Atmospheric Administration (NOAA).

  9. Gulf Coast Hurricanes Situation Report #39

    Energy Technology Data Exchange (ETDEWEB)

    None

    2005-11-09

    There are 49,300 customers without power in Florida as of 7:00 AM EST 11/9 due to Hurricane Wilma, down from a peak of about 3.6 million customers. Currently, less than 1 percent of the customers are without power in the state. This is the last report we will due on outages due to Hurricane Wilma.

  10. Satellite sar detection of hurricane helene (2006)

    DEFF Research Database (Denmark)

    Ju, Lian; Cheng, Yongcun; Xu, Qing;

    2013-01-01

    In this paper, the wind structure of hurricane Helene (2006) over the Atlantic Ocean is investigated from a C-band RADARSAT-1 synthetic aperture radar (SAR) image acquired on 20 September 2006. First, the characteristics, e.g., the center, scale and area of the hurricane eye (HE) are determined...

  11. Hurricane impacts on US forest carbon sequestration

    Science.gov (United States)

    Steven G. McNulty

    2002-01-01

    Recent focus has been given to US forests as a sink for increases in atmospheric carbon dioxide. Current estimates of US Forest carbon sequestration average approximately 20 Tg (i.e. 1012 g) year. However, predictions of forest carbon sequestration often do not include the influence of hurricanes on forest carbon storage. Intense hurricanes...

  12. ADAMS/Car软件中随机路面建立方法%Method on Building Random Road in ADAMS/Car

    Institute of Scientific and Technical Information of China (English)

    赵治

    2012-01-01

    The author introduces four kinds of method to build random road in ADAMS/Car software, it is of reference value with using ADAMS/Car software to simulate velicle ride comfrot.%介绍在ADAMS/Car中四种随机路面的建立方法,对于应用ADAMS/Car进行整车平顺性仿真分析具有参考价值。

  13. 研华ST接口产品介绍——ADAM-6541/ST和ADAM-6521/ST

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    研华推出ST接口系列模块中的两款产品ADAM-6541/ST和ADAM-6521/ST。ADAM-6541/ST是一款以太网到多模式ST光纤转换器;ADAM-6521/ST是一款带有1个多模式光纤ST端口的5端口工业级10/100Mbps以太网交换机。这些模块带有“ST”新型光纤接口,含有一个插头和插槽。能够与一个半螺旋卡口锁定在一起,确保牢固的连接。

  14. ADAM SMITH: THE INVISIBLE HAND OR CONFIDENCE

    Directory of Open Access Journals (Sweden)

    Fernando Luis, Gache

    2010-01-01

    Full Text Available In 1776 Adam Smith raised the matter that an invisible hand was the one which moved the markets to obtain its efficiency. Despite in the present paper we are going to raise the hypothesis, that this invisible hand is in fact the confidence that each person feels when he is going to do business. That in addition it is unique, because it is different from the confidence of the others and that is a variable nonlinear that essentially is ligatured to respective personal histories. For that we are going to take as its bases the paper by Leopoldo Abadía (2009, with respect to the financial economy crisis that happened in 2007-2008, to evidence the form in which confidence operates. Therefore the contribution that we hope to do with this paper is to emphasize that, the level of confidence of the different actors, is the one which really moves the markets, (therefore the economy and that the crisis of the subprime mortgages is a confidence crisis at world-wide level.

  15. Adams-Iwasawa N=8 Black Holes

    CERN Document Server

    Cacciatori, Sergio Luigi; Marrani, Alessio

    2012-01-01

    We study some of the properties of the geometry of the exceptional Lie group E7(7), which describes the U-duality of the N=8, d=4 supergravity. In particular, based on a symplectic construction of the Lie algebra e7(7) due to Adams, we compute the Iwasawa decomposition of the symmetric space M=E7(7)/(SU(8)/Z_2), which gives the vector multiplets' scalar manifold of the corresponding supergravity theory. The explicit expression of the Lie algebra is then used to analyze the origin of M as scalar configuration of the "large" 1/8-BPS extremal black hole attractors. In this framework it turns out that the U(1) symmetry spanning such attractors is broken down to a discrete subgroup Z_4, spoiling their dyonic nature near the origin of the scalar manifold. This is a consequence of the fact that the maximal manifest off-shell symmetry of the Iwasawa parametrization is determined by a completely non-compact Cartan subalgebra of the maximal subgroup SL(8,R) of E7(7), which breaks down the maximal possible covariance SL...

  16. Who taught Adam to speak?1

    Directory of Open Access Journals (Sweden)

    Arthur C. Custance

    1994-03-01

    Full Text Available It is taken for granted that the first man, being half-ape, 'spoke’ by copying them. Research shows that such grunts and cries cannot ‘evolve' into cultured speech because the speech organs and brain structure required for human language are entirety different from those needed for of animal communication. The difference in animal and human thinking processes is not merely one of degree but rather of kind. This difference is seen in the use of signs vs. symbols, of emotional and situational language v.v. conceptual, objective language. No animal communication system can account for the human one. Perhaps, then, speech is instinctive? No, for people, however primitive, have been found without a language. Yet unless spoken to, one does not learn to speak as demonstrated by feral (wild children and deaf-mutes(like Helen Keller. So the question is - who spoke to the first human being - Adam to teach him? About all that scientific investigation can do is to demonstrate what cannot be the origin of this extraordinary trait of human nature. The only light we have is from revelation. The first two chapters of Genesis not only tell us Who spoke first but also how the process of language was acquired. But the implications of the necessity of this unique faculty in terms of his humanity and the purpose of his very creation are profound.

  17. TACE (ADAM17) inhibits Schwann cell myelination.

    Science.gov (United States)

    La Marca, Rosa; Cerri, Federica; Horiuchi, Keisuke; Bachi, Angela; Feltri, M Laura; Wrabetz, Lawrence; Blobel, Carl P; Quattrini, Angelo; Salzer, James L; Taveggia, Carla

    2011-06-12

    Tumor necrosis factor-α-converting enzyme (TACE; also known as ADAM17) is a proteolytic sheddase that is responsible for the cleavage of several membrane-bound molecules. We report that TACE cleaves neuregulin-1 (NRG1) type III in the epidermal growth factor domain, probably inactivating it (as assessed by deficient activation of the phosphatidylinositol-3-OH kinase pathway), and thereby negatively regulating peripheral nervous system (PNS) myelination. Lentivirus-mediated knockdown of TACE in vitro in dorsal root ganglia neurons accelerates the onset of myelination and results in hypermyelination. In agreement, motor neurons of conditional knockout mice lacking TACE specifically in these cells are significantly hypermyelinated, and small-caliber fibers are aberrantly myelinated. Further, reduced TACE activity rescues hypomyelination in NRG1 type III haploinsufficient mice in vivo. We also show that the inhibitory effect of TACE is neuron-autonomous, as Schwann cells lacking TACE elaborate myelin of normal thickness. Thus, TACE is a modulator of NRG1 type III activity and is a negative regulator of myelination in the PNS.

  18. Genesis of tornadoes associated with hurricanes

    Science.gov (United States)

    Gentry, R. C.

    1983-01-01

    The climatological history of hurricane-tornadoes is brought up to date through 1982. Most of the tornadoes either form near the center of the hurricane, from the outer edge of the eyewall outward, or in an area between north and east-southeast of the hurricane center. The blackbody temperatures of the cloud tops which were analyzed for several hurricane-tornadoes that formed in the years 1974, 1975, and 1979, did not furnish strong precursor signals of tornado formation, but followed one of two patterns: either the temperatures were very low, or the tornado formed in areas of strong temperature gradients. Tornadoes with tropical cyclones most frequently occur at 1200-1800 LST, and although most are relatively weak, they can reach the F3 intensity level. Most form in association with the outer rainbands of the hurricane.

  19. Ivan Cankar: Hiša Marije pomočnice (L'anarquista - Fi del capítol 4)

    OpenAIRE

    1992-01-01

    Presentamos la traducción catalana inédita de un fragmento de la novela de Ivan Cankar, Hiša Marije pomočnice (1904). Ellector esloveno, suficientemente familiarizado con la figura y la obra de Ivan Cankar (1876-1918), no precisaná ulterior introducción. No así el lector ibérico sabre el que pesa la desatención del mercado editorial peninsular bacia las literaturas eslavas minoritarias, y muy especialmente bacia la literatura eslovena.

  20. Ivan Cankar: Hiša Marije pomočnice (L'anarquista - Fi del capítol 4

    Directory of Open Access Journals (Sweden)

    Jordi Canals Piñas

    1992-12-01

    Full Text Available Presentamos la traducción catalana inédita de un fragmento de la novela de Ivan Cankar, Hiša Marije pomočnice (1904. Ellector esloveno, suficientemente familiarizado con la figura y la obra de Ivan Cankar (1876-1918, no precisaná ulterior introducción. No así el lector ibérico sabre el que pesa la desatención del mercado editorial peninsular bacia las literaturas eslavas minoritarias, y muy especialmente bacia la literatura eslovena.

  1. Hurricane Katrina deaths, Louisiana, 2005.

    Science.gov (United States)

    Brunkard, Joan; Namulanda, Gonza; Ratard, Raoult

    2008-12-01

    Hurricane Katrina struck the US Gulf Coast on August 29, 2005, causing unprecedented damage to numerous communities in Louisiana and Mississippi. Our objectives were to verify, document, and characterize Katrina-related mortality in Louisiana and help identify strategies to reduce mortality in future disasters. We assessed Hurricane Katrina mortality data sources received in 2007, including Louisiana and out-of-state death certificates for deaths occurring from August 27 to October 31, 2005, and the Disaster Mortuary Operational Response Team's confirmed victims' database. We calculated age-, race-, and sex-specific mortality rates for Orleans, St Bernard, and Jefferson Parishes, where 95% of Katrina victims resided and conducted stratified analyses by parish of residence to compare differences between observed proportions of victim demographic characteristics and expected values based on 2000 US Census data, using Pearson chi square and Fisher exact tests. We identified 971 Katrina-related deaths in Louisiana and 15 deaths among Katrina evacuees in other states. Drowning (40%), injury and trauma (25%), and heart conditions (11%) were the major causes of death among Louisiana victims. Forty-nine percent of victims were people 75 years old and older. Fifty-three percent of victims were men; 51% were black; and 42% were white. In Orleans Parish, the mortality rate among blacks was 1.7 to 4 times higher than that among whites for all people 18 years old and older. People 75 years old and older were significantly more likely to be storm victims (P Hurricane Katrina was the deadliest hurricane to strike the US Gulf Coast since 1928. Drowning was the major cause of death and people 75 years old and older were the most affected population cohort. Future disaster preparedness efforts must focus on evacuating and caring for vulnerable populations, including those in hospitals, long-term care facilities, and personal residences. Improving mortality reporting timeliness will

  2. The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses

    DEFF Research Database (Denmark)

    Marczynska, Joanna; Ozga, Aleksandra; Wlodarczyk, Agnieszka

    2014-01-01

    cells. Shedding is largely attributed to a family of a disintegrin and metalloprotease domain (ADAM) metalloproteases, including ADAM17. Although ADAM17 is well known to contribute to the innate immune response, mainly by releasing TNF-α, much less is known about whether/how this metalloprotease...... regulates adaptive immunity. To determine whether ADAM17 contributes to regulating adaptive immune responses, we took advantage of ADAM17 hypomorphic (ADAM17(ex/ex)) mice, in which ADAM17 expression is reduced by 90-95% compared with wild-type littermates. In this study, we show that that ADAM17 deficiency...... suggest a functional link between ADAM17 and ICOSL in controlling adaptive immune responses....

  3. The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

    LENUS (Irish Health Repository)

    Duffy, Michael J

    2011-06-09

    Abstract The ADAMs are transmembrane proteins implicated in proteolysis and cell adhesion. Forty gene members of the family have been identified, of which 21 are believed to be functional in humans. As proteases, their main substrates are the ectodomains of other transmembrane proteins. These substrates include precursor forms of growth factors, cytokines, growth factor receptors, cytokine receptors and several different types of adhesion molecules. Although altered expression of specific ADAMs has been implicated in different diseases, their best-documented role is in cancer formation and progression. ADAMs shown to play a role in cancer include ADAM9, ADAM10, ADAM12, ADAM15 and ADAM17. Two of the ADAMs, i.e., ADAM10 and 17 appear to promote cancer progression by releasing HER\\/EGFR ligands. The released ligands activate HER\\/EGFR signalling that culminates in increased cell proliferation, migration and survival. Consistent with a causative role in cancer, several ADAMs are emerging as potential cancer biomarkers for aiding cancer diagnosis and predicting patient outcome. Furthermore, a number of selective ADAM inhibitors, especially against ADAM10 and ADAM17, have been shown to have anti-cancer effects. At least one of these inhibitors is now undergoing clinical trials in patients with breast cancer.

  4. ADAM-10 over-expression increases cortical synaptogenesis.

    Science.gov (United States)

    Bell, Karen F S; Zheng, Luyu; Fahrenholz, Falk; Cuello, A Claudio

    2008-04-01

    Cortical cholinergic, glutamatergic and GABAergic terminals become upregulated during early stages of the transgenic amyloid pathology. Abundant evidence suggests that sAPP alpha, the product of the non-amyloidogenic alpha-secretase pathway, is neurotrophic both in vitro and when exogenously applied in vivo. The disintegrin metalloprotease ADAM-10 has been shown to have alpha-secretase activity in vivo. To determine whether sAPP alpha has an endogenous biological influence on cortical presynaptic boutons in vivo, we quantified cortical cholinergic, glutamatergic and GABAergic presynaptic bouton densities in either ADAM-10 moderate expressing (ADAM-10 mo) transgenic mice, which moderately overexpress ADAM-10, or age-matched non-transgenic controls. Both early and late ontogenic time points were investigated. ADAM-10 mo transgenic mice display significantly elevated cortical cholinergic, glutamatergic and GABAergic presynaptic bouton densities at the early time point (8 months). Only the cholinergic presynaptic bouton density remains significantly elevated in late-staged ADAM-10 mo transgenic animals (18 months). To confirm that the observed elevations were due to increased levels of endogenous murine sAPP alpha, exogenous human sAPP alpha was infused into the cortex of non-transgenic control animals for 1 week. Exogenous infusion of sAPP alpha led to significant elevations in the cholinergic, glutamatergic and GABAergic cortical presynaptic bouton populations. These results are the first to demonstrate an in vivo influence of ADAM-10 on neurotransmitter-specific cortical synaptic plasticity and further confirm the neurotrophic influence of sAPP alpha on cortical synaptogenesis.

  5. Deschooling for all? The thought of Ivan Illich in the era of education (and learning for all

    Directory of Open Access Journals (Sweden)

    Jon Igelmo Zaldívar

    2015-02-01

    Full Text Available Shortly after its publication in 1971, Ivan Illich’s Deschooling Society made a significant impact on reports written at the most influential levels of international institutions, such as Edgar Faure’s report for UNSECO, titled Learning to Be: The World of Education Today and Tomorrow (1972. However, Deschooling Society is but one of many aspects in the overall set of criticisms Illich constructed regarding education and its institutions throughout his entire career. With this matter in mind, this article presents a study on the usefulness of Illich’s thoughts on education and its institutions in the debate on the «post-2015 agenda» being promoted by organisations such as UNESCO and the World Bank. The aim is to reclaim this author’s works as key referents in the questioning of the theoretical grounds predominating many international development policies that advocate «Education for All» and «Learning for All» in the 21st century.How to reference this articleIgelmo Zaldívar, J. (2015. Deschooling for all? The thought of Ivan Illich in the era of education (and learning for all. Foro de Educación, 13(18, pp. 93-109. doi: http://dx.doi.org/10.14516/fde.2015.013.018.005

  6. Characterization of Mammalian ADAM2 and Its Absence from Human Sperm.

    Directory of Open Access Journals (Sweden)

    Heejin Choi

    Full Text Available The members of the ADAM (a disintegrin and metalloprotease family are membrane-anchored multi-domain proteins that play prominent roles in male reproduction. ADAM2, which was one of the first identified ADAMs, is the best studied ADAM in reproduction. In the male germ cells of mice, ADAM2 and other ADAMs form complexes that contribute to sperm-sperm adhesion, sperm-egg interactions, and the migration of sperm in the female reproductive tract. Here, we generated specific antibodies against mouse and human ADAM2, and investigated various features of ADAM2 in mice, monkeys and humans. We found that the cytoplasmic domain of ADAM2 might enable the differential association of this protein with other ADAMs in mice. Western blot analysis with the anti-human ADAM2 antibodies showed that ADAM2 is present in the testis and sperm of monkeys. Monkey ADAM2 was found to associate with chaperone proteins in testis. In humans, we identified ADAM2 as a 100-kDa protein in the testis, but failed to detect it in sperm. This is surprising given the results in mice and monkeys, but it is consistent with the failure of ADAM2 identification in the previous proteomic analyses of human sperm. These findings suggest that the reproductive functions of ADAM2 differ between humans and mice. Our protein analysis showed the presence of potential ADAM2 complexes involving yet-unknown proteins in human testis. Taken together, our results provide new information regarding the characteristics of ADAM2 in mammalian species, including humans.

  7. An Examination of Hurricane Emergency Preparedness Planning at Institutions of Higher Learning of the Gulf South Region Post Hurricane Katrina

    Science.gov (United States)

    Ventura, Caterina Gulli

    2010-01-01

    The purpose of the study was to examine hurricane emergency preparedness planning at institutions of higher learning of the Gulf South region following Hurricane Katrina. The problem addressed the impact of Hurricane Katrina on decision-making and policy planning processes. The focus was on individuals that administer the hurricane emergency…

  8. An Examination of Hurricane Emergency Preparedness Planning at Institutions of Higher Learning of the Gulf South Region Post Hurricane Katrina

    Science.gov (United States)

    Ventura, Caterina Gulli

    2010-01-01

    The purpose of the study was to examine hurricane emergency preparedness planning at institutions of higher learning of the Gulf South region following Hurricane Katrina. The problem addressed the impact of Hurricane Katrina on decision-making and policy planning processes. The focus was on individuals that administer the hurricane emergency…

  9. 78 FR 31614 - Implementation of Regulatory Guide 1.221 on Design-Basis Hurricane and Hurricane Missiles

    Science.gov (United States)

    2013-05-24

    ....221 on Design-Basis Hurricane and Hurricane Missiles AGENCY: Nuclear Regulatory Commission. ACTION... guidance regarding the application of Regulatory Guide (RG) 1.221, ``Design-Basis Hurricane and Hurricane... ML13015A688 Interim Staff Guidance-024 on Implementation of Regulatory Guide 1.221 on Design-Basis...

  10. Adam Smith et les passions musicales

    Directory of Open Access Journals (Sweden)

    Marc Parmentier

    2012-02-01

    Full Text Available Dans sa Théorie des sentiments moraux (1759, Adam Smith classe les passions en trois catégories : passions sociales, asociales, égoïstes. Cette classification résulte directement de leur capacité à susciter ou non la sympathie. Les passions sociales apparaissent ainsi comme les plus propres à susciter un écho sympathique. La question à laquelle tente de répondre l'article est de savoir pourquoi ces mêmes passions sociales sont qualifiées par A. Smith de « naturellement musicales ». L'utilisation du concept de sympathie dans le domaine musical est fréquente aux XVIIème et XVIIIème siècles, mais l'hypothèse avancée ici est que le lien est plus profond chez A. Smith. La sympathie met en effet en évidence une qualité d'ordre à la fois esthétique et morale inhérente à certaines passions, leur « convenance » (propriety par opposition aux passions « discordantes ». Ces passions, produisant une superposition d'échos sympathiques comparables aux harmoniques d'un ton fondamental, sont les plus susceptibles d'être imitées par la musique, si l'on tient compte de la théorie esthétique originale formulée par A. Smith, pour qui la beauté des arts imitatifs ne tient pas à l'illusion mais au contraire à l'écart entre l'imitation et son objet.In his Theory of Moral Sentiments, Adam Smith distinguishes three types of passions: social passions, unsocial passions and selfish passions. This classification relies on their capacity to evoke sympathy. Social passions are the most apt to arouse a sympathetic echo in their observers. This article tries to answer the question why A. Smith describes social passions as « naturally musical ». In 17th and 18th centuries sympathy is often mentioned in connection with musical topics, but the link established by A. Smith is more profound. In fact, sympathy reveals an esthetic and moral quality of « convenient », vs « discordant », passions. These passions, that produce

  11. Hurricane Katrina and perinatal health.

    Science.gov (United States)

    Harville, Emily W; Xiong, Xu; Buekens, Pierre

    2009-12-01

    We review the literature on the effects of Hurricane Katrina on perinatal health, and providing data from our own research on pregnant and postpartum women. After Katrina, obstetric, prenatal, and neonatal care was compromised in the short term, but increases in adverse birth outcomes such as preterm birth, low birthweight, and maternal complications were mostly limited to highly exposed women. Both pregnant and postpartum women had rates of post-traumatic stress disorder similar to, or lower than, others exposed to Katrina, and rates of depression similar to other pregnant and postpartum populations. Health behaviors, such as smoking and breastfeeding, may have been somewhat negatively affected by the disaster, whereas effects on nutrition were likely associated with limited time, money, and food choices, and indicated by both weight gain and loss. We conclude that, with a few specific exceptions, postdisaster concerns and health outcomes for pregnant and postpartum women were similar to those of other people exposed to Hurricane Katrina. In such situations, disaster planners and researchers should focus on providing care and support for the normal concerns of the peripartum period, such as breastfeeding, depression, and smoking cessation. Contraception needs to be available for those who do not want to become pregnant. Although additional physical and mental health care needs to be provided for the most severely exposed women and their babies, many women are capable of surviving and thriving in postdisaster environments.

  12. Recovery from PTSD following Hurricane Katrina.

    Science.gov (United States)

    McLaughlin, Katie A; Berglund, Patricia; Gruber, Michael J; Kessler, Ronald C; Sampson, Nancy A; Zaslavsky, Alan M

    2011-06-01

    We examined patterns and correlates of speed of recovery of estimated posttraumatic stress disorder (PTSD) among people who developed PTSD in the wake of Hurricane Katrina. A probability sample of prehurricane residents of areas affected by Hurricane Katrina was administered a telephone survey 7-19 months following the hurricane and again 24-27 months posthurricane. The baseline survey assessed PTSD using a validated screening scale and assessed a number of hypothesized predictors of PTSD recovery that included sociodemographics, prehurricane history of psychopathology, hurricane-related stressors, social support, and social competence. Exposure to posthurricane stressors and course of estimated PTSD were assessed in a follow-up interview. An estimated 17.1% of respondents had a history of estimated hurricane-related PTSD at baseline and 29.2% by the follow-up survey. Of the respondents who developed estimated hurricane-related PTSD, 39.0% recovered by the time of the follow-up survey with a mean duration of 16.5 months. Predictors of slow recovery included exposure to a life-threatening situation, hurricane-related housing adversity, and high income. Other sociodemographics, history of psychopathology, social support, social competence, and posthurricane stressors were unrelated to recovery from estimated PTSD. The majority of adults who developed estimated PTSD after Hurricane Katrina did not recover within 18-27 months. Delayed onset was common. Findings document the importance of initial trauma exposure severity in predicting course of illness and suggest that pre- and posttrauma factors typically associated with course of estimated PTSD did not influence recovery following Hurricane Katrina. © 2011 Wiley-Liss, Inc.

  13. Earth Observations to Assess Impact of Hurricane Katrina on John C. Stennis Space Center

    Science.gov (United States)

    Graham, William D.; Ross, Kenton W.

    2007-01-01

    The peril from hurricanes to Space Operations Centers is real and is forecast to continue; Katrina, Rita, and Wilma of 2005 and Charley, Frances, Ivan, and Jeanne of 2004 are sufficient motivation for NASA to develop a multi-Center plan for preparedness and response. As was demonstrated at SSC (Stennis Space Center) in response to Hurricane Katrina, NASA Centers are efficiently activated as local command centers, playing host to Federal and State agencies and first responders to coordinate and provide evacuation, relocation, response, and recovery activities. Remote sensing decision support provides critical insight for managing NASA infrastructure and for assisting Center decision makers. Managers require geospatial information to manage the federal city. Immediately following Katrina, SSC s power and network connections were disabled, hardware was inoperative, technical staff was displaced and/or out of contact, and graphical decision support tools were non-existent or less than fully effective. Despite this circumstance, SSC EOC (Emergency Operations Center) implemented response operations to assess damage and to activate recovery plans. To assist Center Managers, the NASA ASP (Applied Sciences Program) made its archive of high-resolution data over the site available. In the weeks and months after the immediate crisis, NASA supplemented this data with high-resolution, post-Katrina imagery over SSC and much of the affected coastal areas. Much of the high-resolution imagery was made available through the Department of Defense Clear View contract and was distributed through U.S. Geological Survey Center for Earth Resources Observation and Science "Hurricane Katrina Disaster Response" Web site. By integrating multiple image data types with other information sources, ASP applied an all-source solutions approach to develop decision support tools that enabled managers to respond to critical issues, such as expedient access to infrastructure and deployment of resources

  14. The effect of proximity to hurricanes Katrina and Rita on subsequent hurricane outlook and optimistic bias.

    Science.gov (United States)

    Trumbo, Craig; Lueck, Michelle; Marlatt, Holly; Peek, Lori

    2011-12-01

    This study evaluated how individuals living on the Gulf Coast perceived hurricane risk after Hurricanes Katrina and Rita. It was hypothesized that hurricane outlook and optimistic bias for hurricane risk would be associated positively with distance from the Katrina-Rita landfall (more optimism at greater distance), controlling for historically based hurricane risk and county population density, demographics, individual hurricane experience, and dispositional optimism. Data were collected in January 2006 through a mail survey sent to 1,375 households in 41 counties on the coast (n = 824, 60% response). The analysis used hierarchal regression to test hypotheses. Hurricane history and population density had no effect on outlook; individuals who were male, older, and with higher household incomes were associated with lower risk perception; individual hurricane experience and personal impacts from Katrina and Rita predicted greater risk perception; greater dispositional optimism predicted more optimistic outlook; distance had a small effect but predicted less optimistic outlook at greater distance (model R(2) = 0.21). The model for optimistic bias had fewer effects: age and community tenure were significant; dispositional optimism had a positive effect on optimistic bias; distance variables were not significant (model R(2) = 0.05). The study shows that an existing measure of hurricane outlook has utility, hurricane outlook appears to be a unique concept from hurricane optimistic bias, and proximity has at most small effects. Future extension of this research will include improved conceptualization and measurement of hurricane risk perception and will bring to focus several concepts involving risk communication. © 2011 Society for Risk Analysis.

  15. Structural Characterization of the Ectodomain of a Disintegrin and Metalloproteinase-22 (ADAM22), a Neural Adhesion Receptor Instead of Metalloproteinase INSIGHTS ON ADAM FUNCTION

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Heli; Shim, Ann H.R.; He, Xiaolin; (NWU)

    2009-12-01

    ADAMs (adisintegrin and metalloproteinases) are a family of multidomain transmembrane glycoproteins with diverse roles in physiology and diseases, with several members being drug targets for cancer and inflammation therapies. The spatial organization of the ADAM extracellular segment and its influence on the function of ADAMs have been unclear. Although most members of the ADAM family are active zinc metalloproteinases, 8 of 21 ADAMs lack functional metalloproteinase domains and are implicated in protein-protein interactions instead of membrane protein ectodomain shedding. One of such non-proteinase ADAMs, ADAM22, acts as a receptor on the surface of the postsynaptic neuron to regulate synaptic signal transmission. The crystal structure of the full ectodomain of mature human ADAM22 shows that it is a compact four-leaf clover with the metalloproteinase-like domain held in the concave face of a rigid module formed by the disintegrin, cysteine-rich, and epidermal growth factor-like domains. The loss of metalloproteinase activity is ensured by the absence of critical catalytic residues, the filling of the substrate groove, and the steric hindrance by the cysteine-rich domain. The structure, combined with calorimetric experiments, suggests distinct roles of three putative calcium ions bound to ADAM22, with one in the metalloproteinase-like domain being regulatory and two in the disintegrin domain being structural. The metalloproteinase-like domain contacts the rest of ADAM22 with discontinuous, hydrophilic, and poorly complemented interactions, suggesting the possibility of modular movement of ADAM22 and other ADAMs. The ADAM22 structure provides a framework for understanding how different ADAMs exert their adhesive function and shedding activities.

  16. XII Avatud Ühiskonna Foorumi arutlusring "Euroopa hiilgus ja viletsus - Euroopa Liit 50. Kuidas edasi?" / Toomas Hendrik Ilves, Mark Leonard, Ivan Krastev ; intervjueerinud Andres Kasekamp

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2008-01-01

    Pärnus diskuteerisid 10. oktoobril 2007 Euroopa tuleviku teemadel president Toomas Hendrik Ilves, Euroopa Välissuhete Nõukogu tegevjuht Mark Leonard ja Sofias paikneva Liberaalstrateegiate Keskuse juht Ivan Krastev. Vestluse moderaator oli Eesti Välispoliitika Instituudi direktor, Avatud Eesti Fondi nõukogu esimees Andres Kasekamp

  17. XII Avatud Ühiskonna Foorumi arutlusring "Euroopa hiilgus ja viletsus - Euroopa Liit 50. Kuidas edasi?" / Toomas Hendrik Ilves, Mark Leonard, Ivan Krastev ; intervjueerinud Andres Kasekamp

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2008-01-01

    Pärnus diskuteerisid 10. oktoobril 2007 Euroopa tuleviku teemadel president Toomas Hendrik Ilves, Euroopa Välissuhete Nõukogu tegevjuht Mark Leonard ja Sofias paikneva Liberaalstrateegiate Keskuse juht Ivan Krastev. Vestluse moderaator oli Eesti Välispoliitika Instituudi direktor, Avatud Eesti Fondi nõukogu esimees Andres Kasekamp

  18. Aberrant ADAM10 expression correlates with osteosarcoma progression

    Science.gov (United States)

    2014-01-01

    Background Osteosarcoma is the most common type of bone cancer and is notorious for its rapid progression. The Notch signaling pathway has recently been shown to be involved in osteosarcoma. As a major sheddase of Notch receptors, ADAM10 has been implicated in many types of cancers, but its role in osteosarcoma has not been investigated. Previous studies have shown that the expression of CD31 was significantly elevated in metastatic osteosarcoma; however, its expression in nonmetastatic groups is not known. In addition, the mysterious multinucleated giant cell in giant cell-rich osteosarcoma was previously regarded as an osteoclast-like cell, but its exact identity is unclear. Method Tissue chip samples from 40 cases of nonmetastatic osteosarcoma were stained for cytoplasmic ADAM10, activated Notch1 and CD31. Osteoclasts in tumor sections were also stained for tartrate-resistant acid phosphatase (TRAP). Results Immunofluorescence staining revealed that ADAM10 expression significantly increased with the progression of osteosarcoma as well as in osteoblastic osteosarcoma, whereas the expression of the Notch intracellular domain (NICD) and CD31 was not significantly altered between different pathological stages. In addition, multinucleated giant cells in giant cell-rich osteosarcoma were also found to coexpress CD31, ADAM10 and NICD, but were negative for TRAP staining. Conclusions Our results highlight the importance of ADAM10 in the progression of osteosarcoma and suggest that the protein might be a potential therapeutic target in osteosarcoma treatment. This study also demonstrates that the multinucleated giant cell is an angiogenic tumor cell, rather than an osteoclast, and involves ADAM10/Notch1 signaling activation. PMID:24548763

  19. Hurricanes

    Science.gov (United States)

    ... spawn tornadoes and lead to flooding. The high winds and heavy rains can destroy buildings, roads and bridges, and knock down power lines and trees. In coastal areas, very high tides called storm ...

  20. Hurricanes

    Science.gov (United States)

    ... Awareness Human Trafficking Awareness Month Holiday Stress Homeless Youth Awareness Month Bullying Prevention Domestic Violence Awareness Month Suicide Prevention Month/World Suicide Day Sept. 11th National ...

  1. Hurricane Katrina - Murphy Oil Spill Boundary

    Data.gov (United States)

    U.S. Environmental Protection Agency — Hurricane Katrina made landfall in August 2005, causing widespread devastation along the Gulf Coast of the United States. EPA emergency response personnel worked...

  2. Hurricane Sandy science plan: New York

    Science.gov (United States)

    Ransom, Clarice N.

    2013-01-01

    Hurricane Sandy is a stark reminder of why the Nation must become more resilient to coastal hazards. More than one-half of the U.S. population lives within 50 miles of a coast, and this number is increasing. The U.S. Geological Survey (USGS) is one of the largest providers of geologic and hydrologic information in the world. Federal, State, and local partners depend on the USGS science to know how to prepare for hurricane hazards and reduce losses from future hurricanes. The USGS works closely with other bureaus within the Department of the Interior, the Federal Emergency Management Agency, the National Oceanic Atmospheric Administration, the U.S. Army Corps of Engineers, the Environmental Protection Agency, and many State and local agencies to identify their information needs before, during, and after hurricanes.

  3. Evacuation Shelters - MDC_HurricaneShelter

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — A label feature class of Miami-Dade County Hurricane Evacuation Shelters (HEC) including Special Need Evacuation Centers (SNEC) and Medical Management Facilities...

  4. Tsunamis and Hurricanes A Mathematical Approach

    CERN Document Server

    Cap, Ferdinand

    2006-01-01

    Tsunamis and hurricanes have had a devastating impact on the population living near the coast during the year 2005. The calculation of the power and intensity of tsunamis and hurricanes are of great importance not only for engineers and meteorologists but also for governments and insurance companies. This book presents new research on the mathematical description of tsunamis and hurricanes. A combination of old and new approaches allows to derive a nonlinear partial differential equation of fifth order describing the steepening up and the propagation of tsunamis. The description includes dissipative terms and does not contain singularities or two valued functions. The equivalence principle of solutions of nonlinear large gas dynamics waves and of solutions of water wave equations will be used. An extension of the continuity equation by a source term due to evaporation rates of salt seawater will help to understand hurricanes. Detailed formula, tables and results of the calculations are given.

  5. Final Gulf Coast Hurricanes Situation Report #46

    Energy Technology Data Exchange (ETDEWEB)

    None

    2006-01-26

    According to Entergy New Orleans, electricity has been restored to the vast majority of residents and businesses in the city, except in a few isolated areas that sustained severe devastation from Hurricane Katrina.

  6. Hurricane Irene Poster (August 27, 2011)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Irene poster. Color composite GOES image shows Irene moving through the North Carolina Outer Banks on August 27, 2011. Poster size is 36"x27"

  7. Forecasting OctoberNovember Caribbean hurricane days

    National Research Council Canada - National Science Library

    Philip J. Klotzbach

    2011-01-01

      Late season Caribbean hurricane activity is predictable ENSO and the AWP show skill as predictors for OctNov Caribbean activity OctoberNovember Caribbean activity can significantly impact the US...

  8. Hurricane Katrina - Murphy Oil Spill Boundary

    Science.gov (United States)

    Hurricane Katrina made landfall in August 2005, causing widespread devastation along the Gulf Coast of the United States. EPA emergency response personnel worked with FEMA and state and local agencies to respond to the emergencies throughout the Gulf.

  9. Hurricane Matthew Takes Aim At Florida

    Science.gov (United States)

    ... plan for adequate supplies in case you lose power and water for several days and you are not able to leave due to flooding or blocked roads. Hurricane winds can cause trees and branches to fall, so trim or remove ...

  10. Evacuation Shelters - MDC_HurricaneShelter

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — A label feature class of Miami-Dade County Hurricane Evacuation Shelters (HEC) including Special Need Evacuation Centers (SNEC) and Medical Management Facilities...

  11. Satellite sar detection of hurricane helene (2006)

    DEFF Research Database (Denmark)

    Ju, Lian; Cheng, Yongcun; Xu, Qing

    2013-01-01

    In this paper, the wind structure of hurricane Helene (2006) over the Atlantic Ocean is investigated from a C-band RADARSAT-1 synthetic aperture radar (SAR) image acquired on 20 September 2006. First, the characteristics, e.g., the center, scale and area of the hurricane eye (HE) are determined....... There is a good agreement between the SAR-estimated HE center location and the best track data from the National Hurricane Center. The wind speeds at 10 m above the ocean surface are also retrieved from the SAR data using the geophysical model function (GMF), CMOD5, and compared with in situ wind speed...... observations from the stepped frequency microwave radiometer (SFMR) on NOAA P3 aircraft. All the results show the capability of hurricane monitoring by satellite SAR. Copyright © 2013 by the International Society of Offshore and Polar Engineers (ISOPE)....

  12. Preliminarily functional analysis of a cloned novel human gene ADAM29

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    ADAM is a family of type I integral membrane proteins which are characterized by sharing a disintegrin and metalloprotease domain and involved in many important physiological processes such as fertilization, neurogenesis and inflammatory response. A novel human ADAM gene--ADAM29, which was cloned in our laboratory, is exclusively expressed in human testis and contains a potential fusion domain. A full-length cDNA of ADAM29 was obtained by using multiple-step PCR. Phylogenetic tree of known mammalian ADAMs specifically expressed in testis was reconstructed. Polyclonal antiserum was raised by immunizing the rabbits with sub-peptide of ADAM29 (Leu268-Asp374) as immunogen. The result of immunohistochemical test on human testis showed that ADAM29 is expressed in different stages of spermatogenesis and in interstitial cells. ADAM29 may play a certain role in the signal transduction during the maturation of testis-associated cells.

  13. Harald Velner - insener üle poole sajandi / Harald-Adam Velner

    Index Scriptorium Estoniae

    Velner, Harald-Adam, 1923-2012

    2008-01-01

    Harald-Adam Velner on Eesti Inseneride Liidu esimene taasiseseisvumisjärgne president. Lisaks Liis Seili lühiartikkel Harald-Adam Velneri isast August Velnerist: Teedeinsenerist isa juhtis inseneride ühendust enne sõda

  14. Harald Velner - insener üle poole sajandi / Harald-Adam Velner

    Index Scriptorium Estoniae

    Velner, Harald-Adam, 1923-2012

    2008-01-01

    Harald-Adam Velner on Eesti Inseneride Liidu esimene taasiseseisvumisjärgne president. Lisaks Liis Seili lühiartikkel Harald-Adam Velneri isast August Velnerist: Teedeinsenerist isa juhtis inseneride ühendust enne sõda

  15. Heparan sulfate regulates ADAM12 through a molecular switch mechanism

    DEFF Research Database (Denmark)

    Sørensen, Hans P; Vives, Romain R; Manetopoulos, Christina

    2008-01-01

    tumor progression and chondrocyte proliferation in osteoarthritic cartilage, is shown to possess a pro/catalytic domain cationic molecular switch, regulated by exogenous heparan sulfate and heparin but also endogenous cell surface proteoglycans and the polyanion, calcium pentosan polysulfate. Sheddase...... functions of ADAM12 are regulated by the switch, as are proteolytic functions in placental tissue and sera of pregnant women. Moreover, human heparanase, an enzyme also linked to tumorigenesis, can promote ADAM12 sheddase activity at the cell surface through cleavage of the inhibitory heparan sulfate...

  16. Targeting ADAM12 in human disease: head, body or tail?

    DEFF Research Database (Denmark)

    Jacobsen, J; Wewer, U M

    2009-01-01

    ADAM12/meltrin alpha is a type I transmembrane multidomain protein involved in tumor progression and other severe diseases, including osteoarthritis, and as such could be considered as a potential drug target. In addition to protease activity, ADAM12 possesses cell binding and cell signaling......) and insulin-like growth factor receptor signaling. The body of the protein (consisting of the disintegrin, cysteine-rich, and EGF-like domains) is involved in contacts with the extracellular matrix and other cells through interactions with integrins and syndecans. Finally, the tail of the protein (consisting...

  17. A Functional Role for ADAM10 in Human Immunodeficiency Virus Type-1 Replication

    Directory of Open Access Journals (Sweden)

    Rubin Donald H

    2011-05-01

    Full Text Available Abstract Background Gene trap insertional mutagenesis was used as a high-throughput approach to discover cellular genes participating in viral infection by screening libraries of cells selected for survival from lytic infection with a variety of viruses. Cells harboring a disrupted ADAM10 (A Disintegrin and Metalloprotease 10 allele survived reovirus infection, and subsequently ADAM10 was shown by RNA interference to be important for replication of HIV-1. Results Silencing ADAM10 expression with small interfering RNA (siRNA 48 hours before infection significantly inhibited HIV-1 replication in primary human monocyte-derived macrophages and in CD4+ cell lines. In agreement, ADAM10 over-expression significantly increased HIV-1 replication. ADAM10 down-regulation did not inhibit viral reverse transcription, indicating that viral entry and uncoating are also independent of ADAM10 expression. Integration of HIV-1 cDNA was reduced in ADAM10 down-regulated cells; however, concomitant 2-LTR circle formation was not detected, suggesting that HIV-1 does not enter the nucleus. Further, ADAM10 silencing inhibited downstream reporter gene expression and viral protein translation. Interestingly, we found that while the metalloprotease domain of ADAM10 is not required for HIV-1 replication, ADAM15 and γ-secretase (which proteolytically release the extracellular and intracellular domains of ADAM10 from the plasma membrane, respectively do support productive infection. Conclusions We propose that ADAM10 facilitates replication at the level of nuclear trafficking. Collectively, our data support a model whereby ADAM10 is cleaved by ADAM15 and γ-secretase and that the ADAM10 intracellular domain directly facilitates HIV-1 nuclear trafficking. Thus, ADAM10 represents a novel cellular target class for development of antiretroviral drugs.

  18. The Role of ADAM9 in Tumor-Stromal Interactions in Breast Cancer

    Science.gov (United States)

    2009-04-01

    endogenously express ADAM9-L and –S (Fig 1 ). Year two research focused on using isoform specific antibodies for immunocytochemistry in preparation for...migration. As outlined in the task 2 update, we have shown that the different isoforms of ADAM9 have opposing effects on breast cancer cell migration...both isoforms of ADAM-9, and our future work in this area will further define the relevant signaling pathways which participate in ADAM9 mediated

  19. Drag Coefficient and Foam in Hurricane Conditions.

    Science.gov (United States)

    Golbraikh, E.; Shtemler, Y.

    2016-12-01

    he present study is motivated by recent findings of saturation and even decrease in the drag coefficient (capping) in hurricane conditions, which is accompanied by the production of a foam layer on the ocean surface. As it is difficult to expect at present a comprehensive numerical modeling of the drag coefficient saturation that is followed by wave breaking and foam production, there is no complete confidence and understanding of the saturation phenomenon. Our semi-empirical model is proposed for the estimation of the foam impact on the variation of the effective drag coefficient, Cd , with the reference wind speed U10 in stormy and hurricane conditions. The proposed model treats the efficient air-sea aerodynamic roughness length as a sum of two weighted aerodynamic roughness lengths for the foam-free and foam-covered conditions. On the available optical and radiometric measurements of the fractional foam coverage,αf, combined with direct wind speed measurements in hurricane conditions, which provide the minimum of the effective drag coefficient, Cd for the sea covered with foam. The present model yields Cd10 versus U10 in fair agreement with that evaluated from both open-ocean and laboratory measurements of the vertical variation of mean wind speed in the range of U10 from low to hurricane speeds. The present approach opens opportunities for drag coefficient modeling in hurricane conditions and hurricane intensity estimation by the foam-coverage value using optical and radiometric measurements.

  20. Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity

    DEFF Research Database (Denmark)

    Albrechtsen, Reidar; Hansen, Dorte Stautz; Sanjay, Archana;

    2011-01-01

    -Src interaction site in the ADAM12 cytoplasmic domain, but was independent of the catalytic activity of ADAM12. Caveolin-1 and transmembrane protease MMP14/MT1-MMP were both present in the ADAM12-induced clusters of invadopodia, and cholesterol depletion prevented their formation, suggesting that lipid-raft...

  1. Expression, purification and insights into structure and folding of the ADAM22 pro domain

    DEFF Research Database (Denmark)

    Sørensen, Hans Peter; Jacobsen, Jonas; Nielbo, Steen;

    2008-01-01

    . To understand the functions of human ADAM pro domains and to determine three-dimensional structures, we have screened promising targets for expression and purification properties when using Escherichia coli as the host. The pro domain of ADAM22 (ADAM22-P) expressed in E. coli was folded, as determined by CD...

  2. ADAM 12 as a second-trimester maternal serum marker in screening for Down syndrome

    DEFF Research Database (Denmark)

    Christiansen, Michael; Spencer, Kevin; Laigaard, Jennie

    2007-01-01

    ADAM 12 is a placenta-derived glycoprotein that is involved in growth and differentiation. The maternal serum concentration of ADAM 12 is a potential first-trimester maternal serum marker of Down syndrome (DS). Here we examine the potential of ADAM 12 as a second-trimester maternal serum marker...

  3. ADAM19 expression in human nephrogenesis and renal disease : Associations with clinical and structural deterioration

    NARCIS (Netherlands)

    Melenhorst, W. B. W. H.; van den Heuvel, M. C.; Timmer, A.; Huitema, S.; Bulthuis, M.; Timens, W.; van Goor, H.

    2006-01-01

    ADAM19, an enzyme from the ADAM (a disintegrin and metalloproteinase) family, is involved in various cell-cell and cell-matrix interactions. It can cleave epidermal growth factor (EGF)-like growth factors, such as heparin-binding (HB)-EGF and neuregulin (NRG), from the cell membrane. ADAM-mediated E

  4. Cell-surface metalloprotease ADAM12 is internalized by a clathrin- and Grb2-dependent mechanism

    DEFF Research Database (Denmark)

    Hansen, Dorte Stautz; Leyme, Anthony; Grandal, Michael Vibo;

    2012-01-01

    ADAM12 (A Disintegrin And Metalloprotease 12), a member of the ADAMs family of transmembrane proteins, is involved in ectodomain shedding, cell-adhesion and signaling, with important implications in cancer. Therefore, mechanisms that regulate the levels and activity of ADAM12 at the cell-surface ...

  5. Regulation of ADAM12 cell-surface expression by protein kinase C epsilon

    DEFF Research Database (Denmark)

    Sundberg, Christina; Thodeti, Charles Kumar; Kveiborg, Marie;

    2004-01-01

    as a constitutively active protein. However, little is known about the regulation of ADAM12 cell-surface translocation. Here, we used human RD rhabdomyosarcoma cells, which express ADAM12 at the cell surface, in a temporal pattern. We report that protein kinase C (PKC) epsilon induces ADAM12 translocation to the cell...

  6. HISTORIA ECONÓMICA: El padre de la economia:Adam Smith

    OpenAIRE

    Accensi Martínez, Maria Cinta

    2016-01-01

    Peer-reviewed Artículo que describe una pequeña bibliografía del padre de la economía Adam Smith Article que descriu una petita bibliografia sobre el pare de l'economia Adam Smith. This article include a brief bibliography about Adam Smith.

  7. Ivan Nepomuk Cratey i njegov plan reforme poštanske službe u Dalmaciji 1804. godine

    OpenAIRE

    Škorić, Tihana

    2017-01-01

    U ovom radu analizira se reforma poštanske službe u Dalmaciji koju je 1804. godine u obliku izvještaja predstavio prvi upravitelj i ravnatelj pošte za Dalmaciju i Albaniju,1 Ivan Nepomuk Cratey. Kao izvorno arhivsko gradivo, izvještaj je u potpunosti sačuvan i pohranjen u Allgemeines Verwaltungsarchiv u Beču. Njegova analiza nije važna samo zato što daje odgovor na mnoga pitanja vezana za povijest i razvoj poštanske službe u Dalmaciji, već i zato što rasvjetljava političku, gospodarsku i druš...

  8. Compendious Introduction of Co-simulation and ADAMS/Controls%联合仿真技术及ADAMS/Controls

    Institute of Scientific and Technical Information of China (English)

    孙秀军; 王效岳; 杨燕

    2007-01-01

    ADAMS是机械系统动力学分析软件,MATLAB/Simulink是控制系统建模及仿真软件,运用ADAMS/Controls模块作为两软件的接口,可以实现机械系统与控制系统的联合仿真.简单介绍了联合仿真、ADAMS/Controls和MATLAB/Simulink,最后给出了球-梁模型联合仿真设计实例.

  9. Tuning a Le Mans Car Suspension in ADAMS

    CSIR Research Space (South Africa)

    Berman, R

    2012-09-01

    Full Text Available An ADAMS model of South Africa’s first ever Le Mans car was developed and used to tune the suspension parameters. Validation of the model is to be done by comparing simulation results to those obtained in track testing. The suspension parameters...

  10. ADAM: A Collaborative Effort To Prepare Future Administrators.

    Science.gov (United States)

    Richardson, Michael D.; And Others

    ADAM (Administrative Development and Management), an administrator preparation partnership between Greenwood (South Carolina) School District 50 and Clemson University, is described in this paper. The program uses practicing administrators in collaboration with college faculty to train prospective school administrators. The purpose is to provide…

  11. Adams operations on higher arithmetic K-theory

    DEFF Research Database (Denmark)

    Feliu, Elisenda

    2010-01-01

    We construct Adams operations on the rational higher arithmetic K-groups of a proper arithmetic variety. The de¿nition applies to the higher arithmetic K-groups given by Takeda as well as to the groups suggested by Deligne and Soulé, by means of the homotopy groups of the homotopy ¿ber of the reg......We construct Adams operations on the rational higher arithmetic K-groups of a proper arithmetic variety. The de¿nition applies to the higher arithmetic K-groups given by Takeda as well as to the groups suggested by Deligne and Soulé, by means of the homotopy groups of the homotopy ¿ber...... of the regulator map. They are compatible with the Adams operations on algebraic K-theory. The de¿nition relies on the chain morphism representing Adams operations in higher algebraic K-theory given previously by the author. It is shown that this chain morphism commutes strictly with the representative...

  12. Father Knows Best: Using Adam Smith to Teach Transactions Costs

    Science.gov (United States)

    Dupont, Brandon

    2014-01-01

    Adam Smith's moral philosophy can be used to introduce economics students to the important idea of transactions costs. The author provides a brief background in this article to Smith's moral philosophy and connects it to the costs of transacting in a way that fits easily into the standard principles of microeconomics classroom. By doing…

  13. Adam Smith and the Teaching of English Literature.

    Science.gov (United States)

    Court, Franklin E.

    1985-01-01

    Adam Smith used selections from English literature in his classroom during the eighteenth century because he believed that vernacular literature could provide a ready context for the teaching of ideological, social, and moral lessons. He believed that higher education should prepare students for the real business of the real world. (RM)

  14. Adam Smith and the Moral Economy of the Classroom System.

    Science.gov (United States)

    Hamilton, D.

    1980-01-01

    Traces the development of mass schooling to its origins in 19th-century Glasgow. Its importance as an intellectual and economic center enabled Glasgow to invent a solution to the problem of urban schooling, while the association of scholars like Adam Smith with Glasgow University made Scottish educational theories acceptable around the world. (DB)

  15. Indian Policy of John Adams Administration: Treaties with the Indians

    Directory of Open Access Journals (Sweden)

    Nelin Timur V.

    2016-09-01

    Full Text Available In this article the author examines the treaties that were concluded with the Native Americans in the period of John Adams presidency. Treaties with the Natives can be a good source for the study of the US Indian policy. They help to understand the character of Indian-white relations, the attitudes of Federal authorities towards certain Indian nation, the actual problems of the Frontier and so on. Unfortunately the policy of the second President of the USA toward the Native Americans is investigated not so good as the policy of other Presidents of Early American Republic. The study of the treaties helps to know more about John Adams Indian policy. In the years of his presidency only few agreements were signed with the Native American tribes. These were the Mohawk, the Seneca, the Oneida of the Iroquois Nation and the Cherokee. The procedure of Indian-white agreements was well developed until 1797 year. And John Adams administration did not explore something new in this question. The second President of the United States adopted the George Washington’s principals of dealing with the Natives. But in fact he had to consider the internal and external situation in the country. The treaties with the Indians, concluded by the administration of John Adams did not become a bright episode of American history. However they helped to reduce tensions in US-Indian relations.

  16. Adams operations on higher arithmetic K-theory

    DEFF Research Database (Denmark)

    Feliu, Elisenda

    2010-01-01

    We construct Adams operations on the rational higher arithmetic K-groups of a proper arithmetic variety. The de¿nition applies to the higher arithmetic K-groups given by Takeda as well as to the groups suggested by Deligne and Soulé, by means of the homotopy groups of the homotopy ¿ber of the reg......We construct Adams operations on the rational higher arithmetic K-groups of a proper arithmetic variety. The de¿nition applies to the higher arithmetic K-groups given by Takeda as well as to the groups suggested by Deligne and Soulé, by means of the homotopy groups of the homotopy ¿ber...... of the regulator map. They are compatible with the Adams operations on algebraic K-theory. The de¿nition relies on the chain morphism representing Adams operations in higher algebraic K-theory given previously by the author. It is shown that this chain morphism commutes strictly with the representative...

  17. Adam Smith and the Moral Economy of the Classroom System.

    Science.gov (United States)

    Hamilton, D.

    1980-01-01

    Traces the development of mass schooling to its origins in 19th-century Glasgow. Its importance as an intellectual and economic center enabled Glasgow to invent a solution to the problem of urban schooling, while the association of scholars like Adam Smith with Glasgow University made Scottish educational theories acceptable around the world. (DB)

  18. Adam Smith and the Teaching of English Literature.

    Science.gov (United States)

    Court, Franklin E.

    1985-01-01

    Adam Smith used selections from English literature in his classroom during the eighteenth century because he believed that vernacular literature could provide a ready context for the teaching of ideological, social, and moral lessons. He believed that higher education should prepare students for the real business of the real world. (RM)

  19. Father Knows Best: Using Adam Smith to Teach Transactions Costs

    Science.gov (United States)

    Dupont, Brandon

    2014-01-01

    Adam Smith's moral philosophy can be used to introduce economics students to the important idea of transactions costs. The author provides a brief background in this article to Smith's moral philosophy and connects it to the costs of transacting in a way that fits easily into the standard principles of microeconomics classroom. By doing…

  20. ADAM10 modulates calcitriol-regulated RAGE in cardiomyocytes.

    Science.gov (United States)

    Lee, Ting-Wei; Kao, Yu-Hsun; Lee, Ting-I; Chen, Yi-Jen

    2017-09-01

    Receptor for advanced glycation end products (RAGE) signalling plays a critical role in the pathogenesis of cardiovascular disease. Calcitriol modulates cardiac RAGE expression. This study explored the mechanisms underlying the effect of calcitriol on RAGE and soluble RAGE (sRAGE) expression in cardiomyocytes. Western blot, ELISA, fluorometric assay and PCR analyses were used to evaluate the RAGE, sRAGE, endogenous secretory RAGE (esRAGE), Jun N-terminal kinase (JNK), and a disintegrin and metalloprotease 10 (ADAM10) expression and enzyme activity in HL-1 atrial myocytes without and with calcitriol (10 and 100 nM), nuclear factor-κB (NF-κB) inhibitor (50 μg/mL), or ADAM10 inhibitor (5 μM) incubation for 48 h. Calcitriol (10 nM) significantly reduced RAGE protein expression and increased sRAGE concentrations in HL-1 cardiomyocytes compared with control cells. These changes were associated with increased protein expression and enzyme activity of ADAM10 and higher mRNA expression of esRAGE. In the presence of ADAM10 inhibitor, however, the suppressive effect of calcitriol on RAGE was diminished. Methylglyoxal (500 μM for 10 min)-mediated JNK phosphorylation was attenuated in the presence of calcitriol (10 nM). Moreover, control and NF-κB inhibitor-treated HL-1 cells had similar RAGE and sRAGE expression, suggesting that calcitriol-mediated RAGE modulation was independent of NF-κB signalling. We showed that RAGE downregulation and increased sRAGE production by calcitriol were mediated through ADAM10 activation in cardiomyocytes. The results suggest that calcitriol has therapeutic potential in treating RAGE-mediated cardiovascular complications. © 2017 Stichting European Society for Clinical Investigation Journal Foundation.

  1. Trafficking of human ADAM 12-L: retention in the trans-Golgi network

    DEFF Research Database (Denmark)

    Hougaard, S; Loechel, F; Xu, X

    2000-01-01

    We have investigated the trafficking of the membrane-anchored form of human ADAM 12 (ADAM 12-L) fused to a green fluorescence protein tag. Subcellular localization of the protein in transiently transfected cells was determined by fluorescence microscopy and trypsin sensitivity. Full-length ADAM 12...... the cytoplasmic and transmembrane domains, but not the Src homology 3 domain (SH3) binding sites. These results raise the possibility that a trafficking checkpoint in the trans-Golgi network is one of the cellular mechanisms for regulation of ADAM 12-L function, by allowing a rapid release of ADAM 12-L...

  2. Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice.

    Directory of Open Access Journals (Sweden)

    Lauren Folgosa Cooley

    Full Text Available ADAM10, as the sheddase of the low affinity IgE receptor (CD23, promotes IgE production and thus is a unique target for attenuating allergic disease. Herein, we describe that B cell levels of ADAM10, specifically, are increased in allergic patients and Th2 prone WT mouse strains (Balb/c and A/J. While T cell help augments ADAM10 expression, Balb WT B cells exhibit increased ADAM10 in the naïve state and even more dramatically increased ADAM10 after anti-CD40/IL4 stimulation compared C57 (Th1 prone WT B cells. Furthermore, ADAM17 and TNF are reduced in allergic patients and Th2 prone mouse strains (Balb/c and A/J compared to Th1 prone controls. To further understand this regulation, ADAM17 and TNF were studied in C57Bl/6 and Balb/c mice deficient in ADAM10. C57-ADAM10B-/- were more adept at increasing ADAM17 levels and thus TNF cleavage resulting in excess follicular TNF levels and abnormal secondary lymphoid tissue architecture not noted in Balb-ADAM10B-/-. Moreover, the level of B cell ADAM10 as well as Th context is critical for determining IgE production potential. Using a murine house dust mite airway hypersensitivity model, we describe that high B cell ADAM10 level in a Th2 context (Balb/c WT is optimal for disease induction including bronchoconstriction, goblet cell metaplasia, mucus, inflammatory cellular infiltration, and IgE production. Balb/c mice deficient in B cell ADAM10 have attenuated lung and airway symptoms compared to Balb WT and are actually most similar to C57 WT (Th1 prone. C57-ADAM10B-/- have even further reduced symptomology. Taken together, it is critical to consider both innate B cell levels of ADAM10 and ADAM17 as well as Th context when determining host susceptibility to allergic disease. High B cell ADAM10 and low ADAM17 levels would help diagnostically in predicting Th2 disease susceptibility; and, we provide support for the use ADAM10 inhibitors in treating Th2 disease.

  3. 2005 Significant U.S. Hurricane Strikes Poster

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 2005 Significant U.S. Hurricane Strikes poster is one of two special edition posters for the Atlantic Hurricanes. This beautiful poster contains two sets of...

  4. Hurricane Imaging Radiometer (HIRAD) Wind Speed Retrieval Assessment with Dropsondes

    Science.gov (United States)

    Cecil, Daniel J.; Biswas, Sayak K.

    2017-01-01

    Map surface wind speed over wide swath (approximately 50-60 km, for aircraft greater than FL600) in hurricanes. Provide research data for understanding hurricane structure, and intensity change. Enable improved forecasts, warnings, and decision support.

  5. Tracks of Major Hurricanes of the Western Hemisphere

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 36"x24" National Hurricane Center poster depicts the complete tracks of all major hurricanes in the north Atlantic and eastern north Pacific basins since as...

  6. Identification of Caribbean basin hurricanes from Spanish documentary sources

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Herrera, R. [Depto. Fisica de la Tierra II, Facultad de Ciencias Fisicas, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid (Spain); Gimeno, L. [Universidad de Vigo, Ourense (Spain); Ribera, P.; Gonzalez, E.; Fernandez, G. [Universidad Pablo de Olavide, Sevilla (Spain); Hernandez, E. [Universidad Complutense de Madrid, Madrid (Spain)

    2007-07-15

    This paper analyses five hurricanes that occurred in the period 1600 to 1800. These examples were identified during a systematic search in the General Archive of the Indies (AGI) in Seville. The research combined the expertise of climatologists and historians in order to optimise the search and analysis strategies. Results demonstrate the potential of this archive for the assessment of hurricanes in this period and show some of the difficulties involved in the collection of evidence of hurricane activity. The documents provide detailed descriptions of a hurricane's impacts and allow us to identify previously unreported hurricanes, obtain more precise dates for hurricanes previously identified, better define the area affected by a given hurricane and, finally, better assess a hurricane's intensity.

  7. Continental United States Hurricane Strikes 1950-2012

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Continental U.S. Hurricane Strikes Poster is our most popular poster which is updated annually. The poster includes all hurricanes that affected the U.S. since...

  8. Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors

    Science.gov (United States)

    Dazzo, Emanuela; Belluzzi, Elisa; Malacrida, Sandro; Vitiello, Libero; Greggio, Elisa; Tosatto, Silvio C. E.

    2016-01-01

    Autosomal dominant lateral temporal epilepsy (ADTLE) is a focal epilepsy syndrome caused by mutations in the LGI1 gene, which encodes a secreted protein. Most ADLTE-causing mutations inhibit LGI1 protein secretion, and only a few secretion-positive missense mutations have been reported. Here we describe the effects of four disease-causing nonsynonymous LGI1 mutations, T380A, R407C, S473L, and R474Q, on protein secretion and extracellular interactions. Expression of LGI1 mutant proteins in cultured cells shows that these mutations do not inhibit protein secretion. This finding likely results from the lack of effects of these mutations on LGI1 protein folding, as suggested by 3D protein modelling. In addition, immunofluorescence and co-immunoprecipitation experiments reveal that all four mutations significantly impair interaction of LGI1 with the ADAM22 and ADAM23 receptors on the cell surface. These results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to ADLTE. PMID:27760137

  9. ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis.

    Directory of Open Access Journals (Sweden)

    Sudipta Das

    Full Text Available ADAM17 (a disintegrin and metalloprotease 17 is a major sheddase for numerous growth factors, cytokines, receptors, and cell adhesion molecules and is often overexpressed in malignant cells. It is generally accepted that ADAM17 promotes tumor development via activating growth factors from the EGF family, thus facilitating autocrine stimulation of tumor cell proliferation and migration. Here we show, using MC38CEA murine colon carcinoma model, that ADAM17 also regulates tumor angiogenesis and cytokine profile. When ADAM17 was silenced in MC38CEA cells, in vivo tumor growth and in vitro cell motility were significantly diminished, but no effect was seen on in vitro cell proliferation. ADAM17-silencing was accompanied by decreased in vitro expression of vascular endothelial growth factor-A and matrix metalloprotease-9, which was consistent with the limited angiogenesis and slower growth seen in ADAM17-silenced tumors. Among the growth factors susceptible to shedding by ADAM17, neuregulin-1 was the only candidate to mediate the effects of ADAM17 on MC38CEA motility and tumor angiogenesis. Concentrations of TNF and IFNγ, cytokines that synergistically induced proapoptotic effects on MC38CEA cells, were significantly elevated in the lysates of ADAM17-silenced tumors compared to mock transfected controls, suggesting a possible role for ADAM17 in host immune suppression. These results introduce new, complex roles of ADAM17 in tumor progression, including its impact on the anti-tumor immune response.

  10. The interaction between ADAM22 and 14-3-3β

    Institute of Scientific and Technical Information of China (English)

    ZHU; Pengcheng(朱鹏程); SANG; Yingying(桑瑛颖); XU; Rener(徐人尔); ZHAO; Jing(赵璟); LI; Changben(李昌本); ZHAO; Shouyuan(赵寿元)

    2002-01-01

    ADAM family consists of a number of transmembrane proteins that contain a disintegrin and metalloprotease domain. ADAMs are involved in a highly diverse set of biological processes, including fertilization, neurogenesis, myogenesis and inflammatory response. The ADAM proteins have both cell adhesion and protease activities. Adam22 is highly expressed in human brain. The adam22-/- mice presented severe ataxia and died before weaning, but the function of ADAM22 is still unknown. 14-3-3β interacting with ADAM22 was detected by using yeast two-hybrid assay. The specificity of interaction between ADAM22 and 14-3-3β was proved by in vitro binding assay and immunoprecipitation. The major 14-3-3β binding site was located in the last 28 amino acid residues of ADAM22 cytoplasmic tail. Protein 14-3-3β is abundant and plays an important role in mediating cell diffusion, migration and cell cycle control. The interaction of ADAM22 and 14-3-3β suggests that the ADAM22 may play a crucial role in neural function and development.

  11. ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis.

    Science.gov (United States)

    Das, Sudipta; Czarnek, Maria; Bzowska, Monika; Mężyk-Kopeć, Renata; Stalińska, Krystyna; Wyroba, Barbara; Sroka, Jolanta; Jucha, Jarosław; Deneka, Dawid; Stokłosa, Paulina; Ogonek, Justyna; Swartz, Melody A; Madeja, Zbigniew; Bereta, Joanna

    2012-01-01

    ADAM17 (a disintegrin and metalloprotease 17) is a major sheddase for numerous growth factors, cytokines, receptors, and cell adhesion molecules and is often overexpressed in malignant cells. It is generally accepted that ADAM17 promotes tumor development via activating growth factors from the EGF family, thus facilitating autocrine stimulation of tumor cell proliferation and migration. Here we show, using MC38CEA murine colon carcinoma model, that ADAM17 also regulates tumor angiogenesis and cytokine profile. When ADAM17 was silenced in MC38CEA cells, in vivo tumor growth and in vitro cell motility were significantly diminished, but no effect was seen on in vitro cell proliferation. ADAM17-silencing was accompanied by decreased in vitro expression of vascular endothelial growth factor-A and matrix metalloprotease-9, which was consistent with the limited angiogenesis and slower growth seen in ADAM17-silenced tumors. Among the growth factors susceptible to shedding by ADAM17, neuregulin-1 was the only candidate to mediate the effects of ADAM17 on MC38CEA motility and tumor angiogenesis. Concentrations of TNF and IFNγ, cytokines that synergistically induced proapoptotic effects on MC38CEA cells, were significantly elevated in the lysates of ADAM17-silenced tumors compared to mock transfected controls, suggesting a possible role for ADAM17 in host immune suppression. These results introduce new, complex roles of ADAM17 in tumor progression, including its impact on the anti-tumor immune response.

  12. ADAM8 in squamous cell carcinoma of the head and neck: a retrospective study

    Directory of Open Access Journals (Sweden)

    Zielinski Valerie

    2012-02-01

    Full Text Available Abstract Background A disintegrin and metalloproteinase (ADAMs have been associated with multiple malignancies. ADAMs are involved in cell fusion, cell migration, membrane protein shedding and proteolysis. ADAM8 has been found to be overexpressed in squamous cell carcinomas of the lung. A new study showed that ADAM8 is significantly overexpressed in metastasis of squamous cell carcinomas of the head and neck (HNSCC. Methods We determined ADAM8 levels in the serum of 79 HNSCC patients at the time of diagnosis, in 35 patients 3 months after treatment and in 10 patients 1 year after therapy and compared the results to the sera of 31 healthy volunteers. We also constructed tissue microarrays to detect ADAM8 immunohistochemically in 100 patients. The results were correlated with the survival data of the patients to determine the diagnostic and prognostic value. Results The data demonstrated that patients with high ADAM8 expression in the tumor have worse survival rates. We found that high ADAM8 serum levels correlated with high ADAM8 expression in tumor samples. Soluble ADAM8 levels did not show any prognostic or diagnostic properties. Conclusion In summary ADAM8 expression is a prognostic factor for survival of patients with head and neck squamous cell carcinoma.

  13. Child mortality after Hurricane Katrina.

    Science.gov (United States)

    Kanter, Robert K

    2010-03-01

    Age-specific pediatric health consequences of community disruption after Hurricane Katrina have not been analyzed. Post-Katrina vital statistics are unavailable. The objectives of this study were to validate an alternative method to estimate child mortality rates in the greater New Orleans area and compare pre-Katrina and post-Katrina mortality rates. Pre-Katrina 2004 child mortality was estimated from death reports in the local daily newspaper and validated by comparison with pre-Katrina data from the Louisiana Department of Health. Post-Katrina child mortality rates were analyzed as a measure of health consequences. Newspaper-derived estimates of mortality rates appear to be valid except for possible underreporting of neonatal rates. Pre-Katrina and post-Katrina mortality rates were similar for all age groups except infants. Post-Katrina, a 92% decline in mortality rate occurred for neonates (Katrina decline in infant mortality rate exceeds the pre-Katrina discrepancy between newspaper-derived and Department of Health-reported rates. A declining infant mortality rate raises questions about persistent displacement of high-risk infants out of the region. Otherwise, there is no evidence of long-lasting post-Katrina excess child mortality. Further investigation of demographic changes would be of interest to local decision makers and planners for recovery after public health emergencies in other regions.

  14. Cold wake of Hurricane Frances

    Science.gov (United States)

    D'Asaro, Eric A.; Sanford, Thomas B.; Niiler, P. Peter; Terrill, Eric J.

    2007-08-01

    An array of instruments air-deployed ahead of Hurricane Frances measured the three-dimensional, time dependent response of the ocean to this strong (60 ms-1) storm. Sea surface temperature cooled by up to 2.2°C with the greatest cooling occurring in a 50-km-wide band centered 60-85 km to the right of the track. The cooling was almost entirely due to vertical mixing, not air-sea heat fluxes. Currents of up to 1.6 ms-1 and thermocline displacements of up to 50 m dispersed as near-inertial internal waves. The heat in excess of 26°C, decreased behind the storm due primarily to horizontal advection of heat away from the storm track, with a small contribution from mixing across the 26°C isotherm. SST cooling under the storm core (0.4°C) produced a 16% decrease in air-sea heat flux implying an approximately 5 ms-1 reduction in peak winds

  15. ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression

    DEFF Research Database (Denmark)

    Frohlich, Camilla; Nehammer, Camilla; Albrechtsen, Reidar

    2011-01-01

    Expression of ADAM12 is low in most normal tissues, but is markedly increased in numerous human cancers, including breast carcinomas. We have previously shown that overexpression of ADAM12 accelerates tumor progression in a mouse model of breast cancer (PyMT). In the present study, we found...... that ADAM12 deficiency reduces breast tumor progression in the PyMT model. However, the catalytic activity of ADAM12 appears to be dispensable for its tumor-promoting effect. Interestingly, we demonstrate that ADAM12 endogenously expressed in tumor-associated stroma in the PyMT model does not influence...... tumor progression, but that ADAM12 expression by tumor cells is necessary for tumor progression in these mice. This finding is consistent with our observation that in human breast carcinoma ADAM12 is almost exclusively located in tumor cells and only rarely seen in the tumor-associated stroma. We...

  16. The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9.

    Science.gov (United States)

    Gutiérrez-López, Maria Dolores; Gilsanz, Alvaro; Yáñez-Mó, María; Ovalle, Susana; Lafuente, Esther M; Domínguez, Carmen; Monk, Peter N; González-Alvaro, Isidoro; Sánchez-Madrid, Francisco; Cabañas, Carlos

    2011-10-01

    ADAM17/TACE is a metalloproteinase responsible for the shedding of the proinflammatory cytokine TNF-α and many other cell surface proteins involved in development, cell adhesion, migration, differentiation, and proliferation. Despite the important biological function of ADAM17, the mechanisms of regulation of its metalloproteinase activity remain largely unknown. We report here that the tetraspanin CD9 and ADAM17 partially co-localize on the surface of endothelial and monocytic cells. In situ proximity ligation, co-immunoprecipitation, crosslinking, and pull-down experiments collectively demonstrate a direct association between these molecules. Functional studies reveal that treatment with CD9-specific antibodies or neoexpression of CD9 exert negative regulatory effects on ADAM17 sheddase activity. Conversely, CD9 silencing increased the activity of ADAM17 against its substrates TNF-α and ICAM-1. Taken together, our results show that CD9 associates with ADAM17 and, through this interaction, negatively regulates the sheddase activity of ADAM17.

  17. 77 FR 74341 - Establishing the Hurricane Sandy Rebuilding Task Force

    Science.gov (United States)

    2012-12-14

    ... the Hurricane Sandy Rebuilding Task Force By the authority vested in me as President by the.... Hurricane Sandy made landfall on October 29, 2012, resulting in major flooding, extensive structural damage... assist the affected region. A disaster of Hurricane Sandy's magnitude merits a comprehensive...

  18. Increase in West Nile neuroinvasive disease after Hurricane Katrina.

    Science.gov (United States)

    Caillouët, Kevin A; Michaels, Sarah R; Xiong, Xu; Foppa, Ivo; Wesson, Dawn M

    2008-05-01

    After Hurricane Katrina, the number of reported cases of West Nile neuroinvasive disease (WNND) sharply increased in the hurricane-affected regions of Louisiana and Mississippi. In 2006, a >2-fold increase in WNND incidence was observed in the hurricane-affected areas than in previous years.

  19. Increase in West Nile Neuroinvasive Disease after Hurricane Katrina

    OpenAIRE

    Caillou?t, Kevin A.; Michaels, Sarah R.; Xiong, Xu; Foppa, Ivo; Wesson, Dawn M.

    2008-01-01

    After Hurricane Katrina, the number of reported cases of West Nile neuroinvasive disease (WNND) sharply increased in the hurricane-affected regions of Louisiana and Mississippi. In 2006, a >2-fold increase in WNND incidence was observed in the hurricane-affected areas than in previous years.

  20. Community College Re-Enrollment after Hurricane Katrina

    Science.gov (United States)

    Lowe, Sarah R.; Rhodes, Jean E.

    2013-01-01

    In this study, we explored predictors of community college re-enrollment after Hurricane Katrina among a sample of low-income women (N = 221). It was predicted that participants' pre-hurricane educational optimism would predict community college re-enrollment a year after the hurricane. The influence of various demographic and additional resources…

  1. ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells.

    Directory of Open Access Journals (Sweden)

    Renata Mężyk-Kopeć

    Full Text Available Tumor-associated lymphatic vessels actively participate in tumor progression and dissemination. ADAM17, a sheddase for numerous growth factors, cytokines, receptors, and cell adhesion molecules, is believed to promote tumor development, facilitating both tumor cell proliferation and migration, as well as tumor angiogenesis. In this work we addressed the issue of whether ADAM17 may also promote tumor lymphangiogenesis. First, we found that ADAM17 is important for the migratory potential of immortalized human dermal lymphatic endothelial cells (LEC. When ADAM17 was stably silenced in LEC, their proliferation was not affected, but: (i single-cell motility, (ii cell migration through a 3D Matrigel/collagen type I matrix, and (iii their ability to form sprouts in a 3D matrix were significantly diminished. The differences in the cell motility between ADAM17-proficient and ADAM17-silenced cells were eliminated by inhibitors of EGFR and HER2, indicating that ADAM17-mediated shedding of growth factors accounts for LEC migratory potential. Interestingly, ADAM17 depletion affected the integrin surface expression/functionality in LEC. ADAM17-silenced cells adhered to plastic, type I collagen, and fibronectin faster than their ADAM17-proficient counterparts. The difference in adhesion to fibronectin was abolished by a cyclic RGD peptide, emphasizing the involvement of integrins in the process. Using a soluble receptor array, we identified BIG-H3 among several candidate proteins involved in the phenotypic and behavioral changes of LEC upon ADAM17 silencing. In additional assays, we confirmed the increased expression of BIG-H3, as well as TGFβ2 in ADAM17-silenced LEC. The antilymphangiogenic effects of ADAM17 silencing in lymphatic endothelial cells suggest further relevance of ADAM17 as a potential target in cancer therapy.

  2. ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells.

    Science.gov (United States)

    Mężyk-Kopeć, Renata; Wyroba, Barbara; Stalińska, Krystyna; Próchnicki, Tomasz; Wiatrowska, Karolina; Kilarski, Witold W; Swartz, Melody A; Bereta, Joanna

    2015-01-01

    Tumor-associated lymphatic vessels actively participate in tumor progression and dissemination. ADAM17, a sheddase for numerous growth factors, cytokines, receptors, and cell adhesion molecules, is believed to promote tumor development, facilitating both tumor cell proliferation and migration, as well as tumor angiogenesis. In this work we addressed the issue of whether ADAM17 may also promote tumor lymphangiogenesis. First, we found that ADAM17 is important for the migratory potential of immortalized human dermal lymphatic endothelial cells (LEC). When ADAM17 was stably silenced in LEC, their proliferation was not affected, but: (i) single-cell motility, (ii) cell migration through a 3D Matrigel/collagen type I matrix, and (iii) their ability to form sprouts in a 3D matrix were significantly diminished. The differences in the cell motility between ADAM17-proficient and ADAM17-silenced cells were eliminated by inhibitors of EGFR and HER2, indicating that ADAM17-mediated shedding of growth factors accounts for LEC migratory potential. Interestingly, ADAM17 depletion affected the integrin surface expression/functionality in LEC. ADAM17-silenced cells adhered to plastic, type I collagen, and fibronectin faster than their ADAM17-proficient counterparts. The difference in adhesion to fibronectin was abolished by a cyclic RGD peptide, emphasizing the involvement of integrins in the process. Using a soluble receptor array, we identified BIG-H3 among several candidate proteins involved in the phenotypic and behavioral changes of LEC upon ADAM17 silencing. In additional assays, we confirmed the increased expression of BIG-H3, as well as TGFβ2 in ADAM17-silenced LEC. The antilymphangiogenic effects of ADAM17 silencing in lymphatic endothelial cells suggest further relevance of ADAM17 as a potential target in cancer therapy.

  3. Clinical significance of ADAM-9 in hepatocellular carcinoma%ADAM-9 在肝细胞肝癌中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    边振光; 汤雨; 千年松

    2012-01-01

    Objective:To investigate the clinical significance of ADAM -9 in hepatocellular carcinoma (HCC). Methods: One hundred and sixty - seven cases of HCC were tested for expression of ADAM — 9 by SP immunohisto-chemistry. Results: Among 167 HCC samples,49 (29%) were negative for ADAM -9,118 (71%) had positive ADAM - 9 immunoreactivity. The ADAM - 9 - positive cells in HCC tissues showed unequivocal cytoplasmic and membrane cellular staining pattern. Among 56 normal liver tissue samples,38% of them were positive for ADAM - 9. Significant difference was found between HCC group and normal liver tissue group. HCC tissues with positive ADAM - 9 expression were larger and less differentiated than those with negative expression (P < 0. 05 ). Portal venous invasion , hepatic venous invasion, bile duct invasion, intrahepatic metastasis and high AFP levels were detected significantly more frequently in ADAM — 9 positive group ( P < 0. 05 ). Moreover, ADAM — 9 positive group had significantly poorer outcomes than ADAM - 9 negative group (P < 0. 05 ) . COX analysis showel that AMAD - 9 was an independent prognostic factor for overall survival (P < 0. 05 ). Conclusion: ADAM - 9 may play an important role in the development and metastasis of HCC.%目的:研究ADAM-9在肝细胞肝癌(HCC)中的表达及其与临床病理参数、预后之间的关系.方法:利用免疫组化方法检测167例HCC组织中ADAM-9的表达情况.结果:167例HCC标本中,49例(29%)标本为ADAM-9阴性,118例(71%)标本为ADAM-9阳性;而在56例正常肝组织中间质ADAM-9的表达阳性率为38%,两者比较有显著差异(P<0.05).HCC组织ADAM-9阳性细胞表现出典型的细胞膜和细胞质型表达.单因素分析结果显示ADAM-9在HCC癌组织的表达与肿瘤的大小、分化程度、侵袭转移、高AFP水平和复发有关,差异均具有统计学意义(P<0.05);K-M生存曲线显示ADAM-9阴性表达组生存率高于ADAM-9阳性表达组,

  4. Adams-Based Rover Terramechanics and Mobility Simulator - ARTEMIS

    Science.gov (United States)

    Trease, Brian P.; Lindeman, Randel A.; Arvidson, Raymond E.; Bennett, Keith; VanDyke, Lauren P.; Zhou, Feng; Iagnemma, Karl; Senatore, Carmine

    2013-01-01

    The Mars Exploration Rovers (MERs), Spirit and Opportunity, far exceeded their original drive distance expectations and have traveled, at the time of this reporting, a combined 29 kilometers across the surface of Mars. The Rover Sequencing and Visualization Program (RSVP), the current program used to plan drives for MERs, is only a kinematic simulator of rover movement. Therefore, rover response to various terrains and soil types cannot be modeled. Although sandbox experiments attempt to model rover-terrain interaction, these experiments are time-intensive and costly, and they cannot be used within the tactical timeline of rover driving. Imaging techniques and hazard avoidance features on MER help to prevent the rover from traveling over dangerous terrains, but mobility issues have shown that these methods are not always sufficient. ARTEMIS, a dynamic modeling tool for MER, allows planned drives to be simulated before commands are sent to the rover. The deformable soils component of this model allows rover-terrain interactions to be simulated to determine if a particular drive path would take the rover over terrain that would induce hazardous levels of slip or sink. When used in the rover drive planning process, dynamic modeling reduces the likelihood of future mobility issues because high-risk areas could be identified before drive commands are sent to the rover, and drives planned over these areas could be rerouted. The ARTEMIS software consists of several components. These include a preprocessor, Digital Elevation Models (DEMs), Adams rover model, wheel and soil parameter files, MSC Adams GUI (commercial), MSC Adams dynamics solver (commercial), terramechanics subroutines (FORTRAN), a contact detection engine, a soil modification engine, and output DEMs of deformed soil. The preprocessor is used to define the terrain (from a DEM) and define the soil parameters for the terrain file. The Adams rover model is placed in this terrain. Wheel and soil parameter files

  5. The Department of Defense and Homeland Security relationship: Hurricane Katrina through Hurricane Irene.

    Science.gov (United States)

    Weaver, John Michael

    2015-01-01

    This research explored federal intervention with the particular emphasis on examining how a collaborative relationship between Department of Defense (DOD) and Homeland Security (DHS) led to greater effectiveness between these two federal departments and their subordinates (United States Northern Command and Federal Emergency Management Agency, respectively) during the preparation and response phases of the disaster cycle regarding US continental-based hurricanes. Through the application of a two-phased, sequential mixed methods approach, this study determined how their relationship has led to longitudinal improvements in the years following Hurricane Katrina, focusing on hurricanes as the primary unit of analysis.

  6. Hurricane Katrina: addictive behavior trends and predictors.

    Science.gov (United States)

    Beaudoin, Christopher E

    2011-01-01

    Post-disaster trends in alcohol consumption and cigarette smoking, as well as their predictors, were identified. Methods. Data from cross-sectional and panel surveys of African American adults in New Orleans, Louisiana, were used from before (2004: n = 1,867; 2005: n = 879) and after (2006a: n = 500; 2006b: n = 500) Hurricane Katrina. Alcohol consumption increased significantly from pre- to post-Hurricane Katrina, while cigarette smoking remained constant. In 2006, posttraumatic stress disorder (PTSD) was associated with cigarette smoking, whereas "news attention" and "provided social support" were inversely associated with cigarette smoking. "News attention" was also inversely associated with cigarette smoking frequency, while "neighborliness" was associated with alcohol consumption. In addition, the effects of PTSD on alcohol consumption were moderated by "neighborliness." In the wake of Hurricane Katrina, there were complex predictive processes of addictive behaviors involving PTSD, news information, and social capital-related measures.

  7. Evaluation of TRIGRS (transient rainfall infiltration and grid-based regional slope-stability analysis)'s predictive skill for hurricane-triggered landslides: A case study in Macon County, North Carolina

    Science.gov (United States)

    Liao, Z.; Hong, Y.; Kirschbaum, D.; Adler, R.F.; Gourley, J.J.; Wooten, R.

    2011-01-01

    The key to advancing the predictability of rainfall-triggered landslides is to use physically based slope-stability models that simulate the transient dynamical response of the subsurface moisture to spatiotemporal variability of rainfall in complex terrains. TRIGRS (transient rainfall infiltration and grid-based regional slope-stability analysis) is a USGS landslide prediction model, coded in Fortran, that accounts for the influences of hydrology, topography, and soil physics on slope stability. In this study, we quantitatively evaluate the spatiotemporal predictability of a Matlab version of TRIGRS (MaTRIGRS) in the Blue Ridge Mountains of Macon County, North Carolina where Hurricanes Ivan triggered widespread landslides in the 2004 hurricane season. High resolution digital elevation model (DEM) data (6-m LiDAR), USGS STATSGO soil database, and NOAA/NWS combined radar and gauge precipitation are used as inputs to the model. A local landslide inventory database from North Carolina Geological Survey is used to evaluate the MaTRIGRS' predictive skill for the landslide locations and timing, identifying predictions within a 120-m radius of observed landslides over the 30-h period of Hurricane Ivan's passage in September 2004. Results show that within a radius of 24 m from the landslide location about 67% of the landslide, observations could be successfully predicted but with a high false alarm ratio (90%). If the radius of observation is extended to 120 m, 98% of the landslides are detected with an 18% false alarm ratio. This study shows that MaTRIGRS demonstrates acceptable spatiotemporal predictive skill for landslide occurrences within a 120-m radius in space and a hurricane-event-duration (h) in time, offering the potential to serve as a landslide warning system in areas where accurate rainfall forecasts and detailed field data are available. The validation can be further improved with additional landslide information including the exact time of failure for each

  8. La muerte de Ivan Illitch, de León Tolstoi: elementos para considerar las múltiples dimensiones de la gestión del cuidado

    OpenAIRE

    Luiz Carlos de Oliveira Cecilio

    2009-01-01

    The author uses the short story The Death of Ivan Ilyich, by Leo Tolstoy, to explore the theme of the multiple dimensions of healthcare management (professional, organizational and systemic) by pointing out the omnipresence and complementariness of these dimensions. Although recognizing that there is no hierarchy between these three dimensions, the discussion focuses on the professional dimension, within which professionals meet users, and highlights how this has been the favored territory fo...

  9. BOOK REVIEW - Adrian Liviu Ivan, Teorii și practice ale integrării europene [Theories and Practices of European Integration

    Directory of Open Access Journals (Sweden)

    Adrian Daniel STAN

    2016-06-01

    Full Text Available Teorii și practice ale integrării europene [Theories and Practices of European Integration] is a genuine contribution to understanding how the European Union’s particular character has been adjusted in more than half of century of institutional growth and development. Professor Ivan`s key argument for this book is that the European Union has been shaped as a functional project taking into consideration the diverse heritage and traditions of its Member States. The opening chapter of this book focuses on the particularities of international relations discipline after the Second World War in order to introduce the theme of European Integration Process. This chapter must be analysed in a series of contributions dedicated to the European Integration process and to the theories that made this integration possible because professor Ivan has previously published books such as: Statele Unite ale Europei [The United States of Europe], Sub zodia Statelor Unite ale Europei [Under the Sign of the United States of Europe], in which he debates the origins of the European construction and brings forward arguments to support the importance of each theoretical and functional pillar of this “Common European Project”.

  10. Application of the ADAMS program to deployable space truss structures

    Science.gov (United States)

    Calleson, R. E.

    1985-01-01

    The need for a computer program to perform kinematic and dynamic analyses of large truss structures while deploying from a packaged configuration in space led to the evaluation of several existing programs. ADAMS (automatic dynamic analysis of mechanical systems), a generalized program from performing the dynamic simulation of mechanical systems undergoing large displacements, is applied to two concepts of deployable space antenna units. One concept is a one cube folding unit of Martin Marietta's Box Truss Antenna and the other is a tetrahedral truss unit of a Tetrahedral Truss Antenna. Adequate evaluation of dynamic forces during member latch-up into the deployed configuration is not yet available from the present version of ADAMS since it is limited to the assembly of rigid bodies. Included is a method for estimating the maximum bending stress in a surface member at latch-up. Results include member displacement and velocity responses during extension and an example of member bending stresses at latch-up.

  11. Adam Smith, Market and Social Change: Then and Now

    DEFF Research Database (Denmark)

    Bouchet, Dominique

    2017-01-01

    Adam Smith (1723-1790) provided us with a remarkable synthesis of the economic and political ideas of his time and developed a conceptual system to analyse social interactions that mattered for the wealth of nations. He proposed a radically different roadmap for the future development...... of the society he lived in. The fact that his original analyses were rooted in a given historical context and were founded on a well thought-through conceptual system should not be ignored. The galvanising effect of the dribs and drabs of Adam Smith ideas that have been bandied about are a long way from...... the powerful insights imbued in the original ideas. Putting those back into context, looking into how Smith proceeded then, trying to update his observations, might help us to be more attentive to the market changes and social challenges of our times....

  12. Empathy's purity, sympathy's complexities; De Waal, Darwin and Adam Smith.

    Science.gov (United States)

    van der Weele, Cor

    2011-07-01

    Frans de Waal's view that empathy is at the basis of morality directly seems to build on Darwin, who considered sympathy as the crucial instinct. Yet when we look closer, their understanding of the central social instinct differs considerably. De Waal sees our deeply ingrained tendency to sympathize (or rather: empathize) with others as the good side of our morally dualistic nature. For Darwin, sympathizing was not the whole story of the "workings of sympathy"; the (selfish) need to receive sympathy played just as central a role in the complex roads from sympathy to morality. Darwin's understanding of sympathy stems from Adam Smith, who argued that the presence of morally impure motives should not be a reason for cynicism about morality. I suggest that De Waal's approach could benefit from a more thorough alignment with the analysis of the workings of sympathy in the work of Darwin and Adam Smith.

  13. ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage

    DEFF Research Database (Denmark)

    Roy, Roopali; Wewer, Ulla M; Zurakowski, David

    2004-01-01

    ADAM 12 is a member of a family of disintegrin-containing metalloproteases that have been implicated in a variety of diseases including Alzheimer's disease, arthritis, and cancer. We purified ADAM 12 from the urine of breast cancer patients via Q-Sepharose anion exchange and gelatin-Sepharose aff......ADAM 12 is a member of a family of disintegrin-containing metalloproteases that have been implicated in a variety of diseases including Alzheimer's disease, arthritis, and cancer. We purified ADAM 12 from the urine of breast cancer patients via Q-Sepharose anion exchange and gelatin......-Sepharose affinity chromatography followed by protein identification by matrix-assisted laser desorption/ionization-time of flight mass spectrometry. Four peptides were identified that spanned the amino acid sequence of ADAM 12. Immunoblot analysis using ADAM 12-specific antibodies detected an approximately 68-k......Da band identified as the mature form of ADAM 12. To characterize catalytic properties of ADAM 12, full-length ADAM 12-S was expressed in COS-7 cells and purified. Substrate specificity studies demonstrated that ADAM 12-S degrades gelatin, type IV collagen, and fibronectin but not type I collagen...

  14. ADAM10 regulates transcription factor expression required for plasma cell function.

    Directory of Open Access Journals (Sweden)

    Natalia S Chaimowitz

    Full Text Available A disintegrin and metalloprotease 10 (ADAM10 is a key regulator of cellular processes by shedding extracellular domains of transmembrane proteins. We have previously demonstrated that deletion of B cell expressed ADAM10 results in changes in lymphoid tissue architecture and impaired germinal center (GC formation. In this study, mice were generated in which ADAM10 is deleted in B cells following class switch recombination (ADAM10(Δ/ΔIgG1-cre(+/- mice. Despite normal GC formation, antibody responses were impaired in ADAM10(Δ/ΔIgG1-cre(+/- mice, implicating ADAM10 in post-GC and extrafollicular B cell terminal differentiation. Surprisingly, plasma cell (PC numbers were normal in ADAM10(Δ/ΔIgG1-cre(+/- mice when compared to controls. However, PCs isolated from ADAM10(Δ/ΔIgG1-cre(+/- mice exhibited decreased expression of transcription factors important for PC function: Prdm1, Xbp1 and Irf4. Bcl6 is a GC transcriptional repressor that inhibits the PC transcriptional program and thus must be downregulated for PC differentiation to occur. Bcl6 expression was increased in PCs isolated from ADAM10(Δ/ΔIgG1-cre(+/- mice at both the mRNA and protein level. These results demonstrate that ADAM10 is required for proper transcription factor expression in PCs and thus, for normal PC function.

  15. Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis

    Science.gov (United States)

    Bertram, Anna; Lovric, Svjetlana; Engel, Alissa; Beese, Michaela; Wyss, Kristin; Hertel, Barbara; Park, Joon-Keun; Becker, Jan U.; Kegel, Johanna; Haller, Hermann; Haubitz, Marion

    2015-01-01

    ANCA-associated vasculitides are characterized by inflammatory destruction of small vessels accompanied by enhanced cleavage of membrane-bound proteins. One of the main proteases responsible for ectodomain shedding is disintegrin and metalloproteinase domain-containing protein 17 (ADAM17). Given its potential role in aggravating vascular dysfunction, we examined the role of ADAM17 in active proteinase-3 (PR3)-positive ANCA-associated vasculitis (AAV). ADAM17 concentration was significantly increased in plasma samples from patients with active PR3-AAV compared with samples from patients in remission or from other controls with renal nonvascular diseases. Comparably, plasma levels of the ADAM17 substrate syndecan-1 were significantly enhanced in active AAV. We also observed that plasma-derived ADAM17 retained its specific proteolytic activity and was partly located on extracellular microparticles. Transcript levels of ADAM17 were increased in blood samples of patients with active AAV, but those of ADAM10 or tissue inhibitor of metalloproteinases 3, which inhibits ADAMs, were not. We also performed a microRNA (miR) screen and identified miR-634 as significantly upregulated in blood samples from patients with active AAV. In vitro, miR-634 mimics induced a proinflammatory phenotype in monocyte-derived macrophages, with enhanced expression and release of ADAM17 and IL-6. These data suggest that ADAM17 has a prominent role in AAV and might account for the vascular complications associated with this disease. PMID:25788529

  16. Evaluation of ADAM/1 model for advanced coal extraction concepts

    Science.gov (United States)

    Deshpande, G. K.; Gangal, M. D.

    1982-01-01

    Several existing computer programs for estimating life cycle cost of mining systems were evaluated. A commercially available program, ADAM/1 was found to be satisfactory in relation to the needs of the advanced coal extraction project. Two test cases were run to confirm the ability of the program to handle nonconventional mining equipment and procedures. The results were satisfactory. The model, therefore, is recommended to the project team for evaluation of their conceptual designs.

  17. Synthesis of serotonin transporter imaging agent [125I]ADAM

    Institute of Scientific and Technical Information of China (English)

    LU Chun-Xiong; WU Chun-Ying; JIANG Quan-Fu; CHEN Zheng-Ping; ZHANG Tong-Xing; LI Xiao-Ming; WANG Song-Pei

    2005-01-01

    The synthesis of serotonin transporter imaging agent [125I] -2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine([125I] ADAM) was reported. The chemical structure of the labeling precursor 5- (tributylstannyl) -2-((2-((dimethylamino)methyl)phenyl)thio)phenylamine and all its intermediates were verified by IR,1HNMR and MS. The .radioiodinated compound was prepared using iododestannylation reaction by hydrogen peroxide. Final radiochemical purity was above 95% determined by TLC.

  18. On liberty and crime: Adam Smith and John Stuart Mill

    OpenAIRE

    Ruggiero, Vincenzo

    2008-01-01

    Abstract The author considers some of the works produced by Adam Smith and John Stuart Mill, who from different perspectives discuss notions such as transgression, deviance and crime. It is argued that the analysis of power crime may immensely benefit from an excavation into economics, for its concern about the creation and acquisition of wealth, the legitimacy of certain conducts as opposed to others, and ultimately the circumstances in which competition and enterpris...

  19. ADAM8 Enhances Osteoclast Precursor Fusion and Osteoclast Formation In Vitro and In Vivo

    Science.gov (United States)

    Ishizuka, Hisako; García-Palacios, Verónica; Lu, Ganwei; Subler, Mark A; Zhang, Heju; Boykin, Christina S; Choi, Sun Jin; Zhao, Liena; Patrene, Kenneth; Galson, Deborah L; Blair, Harry C; Hadi, Tamer M; Windle, Jolene J; Kurihara, Noriyoshi; Roodman, G David

    2011-01-01

    ADAM8 expression is increased in the interface tissue around a loosened hip prosthesis and in the pannus and synovium of patients with rheumatoid arthritis, but its potential role in these processes is unclear. ADAM8 stimulates osteoclast (OCL) formation, but the effects of overexpression or loss of expression of ADAM8 in vivo and the mechanisms responsible for the effects of ADAM8 on osteoclastogenesis are unknown. Therefore, to determine the effects of modulating ADAM expression, we generated tartrate-resistant acid phosphatase (TRAP)–ADAM8 transgenic mice that overexpress ADAM8 in the OCL lineage and ADAM8 knockout (ADAM8 KO) mice. TRAP-ADAM8 mice developed osteopenia and had increased numbers of OCL precursors that formed hypermultinucleated OCLs with an increased bone-resorbing capacity per OCL. They also had an enhanced differentiation capacity, increased TRAF6 expression, and increased NF-κB, Erk, and Akt signaling compared with wild-type (WT) littermates. This increased bone-resorbing capacity per OCL was associated with increased levels of p-Pyk2 and p-Src activation. In contrast, ADAM8 KO mice did not display a bone phenotype in vivo, but unlike WT littermates, they did not increase RANKL production, OCL formation, or calvarial fibrosis in response to tumor necrosis factor α (TNF-α) in vivo. Since loss of ADAM8 does not inhibit basal bone remodeling but only blocks the enhanced OCL formation in response to TNF-α, these results suggest that ADAM8 may be an attractive therapeutic target for preventing bone destruction associated with inflammatory disease. © 2011 American Society for Bone and Mineral Research. PMID:20683884

  20. ADAM17 deletion in thymic epithelial cells alters aire expression without affecting T cell developmental progression.

    Directory of Open Access Journals (Sweden)

    David M Gravano

    Full Text Available BACKGROUND: Cellular interactions between thymocytes and thymic stromal cells are critical for normal T cell development. Thymic epithelial cells (TECs are important stromal niche cells that provide essential growth factors, cytokines, and present self-antigens to developing thymocytes. The identification of genes that mediate cellular crosstalk in the thymus is ongoing. One candidate gene, Adam17, encodes a metalloprotease that functions by cleaving the ectodomain of several transmembrane proteins and regulates various developmental processes. In conventional Adam17 knockout mice, a non-cell autonomous role for ADAM17 in adult T cell development was reported, which strongly suggested that expression of ADAM17 in TECs was required for normal T cell development. However, knockdown of Adam17 results in multisystem developmental defects and perinatal lethality, which has made study of the role of Adam17 in specific cell types difficult. Here, we examined T cell and thymic epithelial cell development using a conditional knockout approach. METHODOLOGY/PRINCIPAL FINDINGS: We generated an Adam17 conditional knockout mouse in which floxed Adam17 is deleted specifically in TECs by Cre recombinase under the control of the Foxn1 promoter. Normal T cell lineage choice and development through the canonical αβ T cell stages was observed. Interestingly, Adam17 deficiency in TECs resulted in reduced expression of the transcription factor Aire. However, no alterations in the patterns of TEC phenotypic marker expression and thymus morphology were noted. CONCLUSIONS/SIGNIFICANCE: In contrast to expectation, our data clearly shows that absence of Adam17 in TECs is dispensable for normal T cell development. Differentiation of TECs is also unaffected by loss of Adam17 based on phenotypic markers. Surprisingly, we have uncovered a novel genetic link between Adam17and Aire expression in vivo. The cell type in which ADAM17 mediates its non-cell autonomous impact and

  1. ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo.

    Science.gov (United States)

    Ishizuka, Hisako; García-Palacios, Verónica; Lu, Ganwei; Subler, Mark A; Zhang, Heju; Boykin, Christina S; Choi, Sun Jin; Zhao, Liena; Patrene, Kenneth; Galson, Deborah L; Blair, Harry C; Hadi, Tamer M; Windle, Jolene J; Kurihara, Noriyoshi; Roodman, G David

    2011-01-01

    ADAM8 expression is increased in the interface tissue around a loosened hip prosthesis and in the pannus and synovium of patients with rheumatoid arthritis, but its potential role in these processes is unclear. ADAM8 stimulates osteoclast (OCL) formation, but the effects of overexpression or loss of expression of ADAM8 in vivo and the mechanisms responsible for the effects of ADAM8 on osteoclastogenesis are unknown. Therefore, to determine the effects of modulating ADAM expression, we generated tartrate-resistant acid phosphatase (TRAP)-ADAM8 transgenic mice that overexpress ADAM8 in the OCL lineage and ADAM8 knockout (ADAM8 KO) mice. TRAP-ADAM8 mice developed osteopenia and had increased numbers of OCL precursors that formed hypermultinucleated OCLs with an increased bone-resorbing capacity per OCL. They also had an enhanced differentiation capacity, increased TRAF6 expression, and increased NF-κB, Erk, and Akt signaling compared with wild-type (WT) littermates. This increased bone-resorbing capacity per OCL was associated with increased levels of p-Pyk2 and p-Src activation. In contrast, ADAM8 KO mice did not display a bone phenotype in vivo, but unlike WT littermates, they did not increase RANKL production, OCL formation, or calvarial fibrosis in response to tumor necrosis factor α (TNF-α) in vivo. Since loss of ADAM8 does not inhibit basal bone remodeling but only blocks the enhanced OCL formation in response to TNF-α, these results suggest that ADAM8 may be an attractive therapeutic target for preventing bone destruction associated with inflammatory disease.

  2. Hurricane Ike: Field Investigation Survey (Invited)

    Science.gov (United States)

    Ewing, L.

    2009-12-01

    Hurricane Ike made landfall at 2:10 a.m. on September 13, 2008, as a Category 2 hurricane. The eye of the hurricane crossed over the eastern end of Galveston Island and a large region of the Texas and Louisiana coast experienced extreme winds, waves and water levels, resulting in large impacts from overtopping, overwash, wind and wave forces and flooding. Major damage stretched from Freeport to the southwest and to Port Arthur to the northeast. The effects of the hurricane force winds were felt well inland in Texas and Louisiana and the storm continued to the interior of the US, causing more damage and loss of life. Through the support of the Coasts, Oceans, Ports and Rivers Institute (COPRI) of the American Society of Civil Engineers (ASCE) a team of 14 coastal scientists and engineers inspected the upper Texas coast in early October 2008. The COPRI team surveyed Hurricane Ike’s effects on coastal landforms, structures, marinas, shore protection systems, and other infrastructure. Damages ranges from very minor to complete destruction, depending upon location and elevation. Bolivar Peninsula, to the right of the hurricane path, experienced severe damage and three peninsula communities were completely destroyed. Significant flood and wave damage also was observed in Galveston Island and Brazoria County that were both on the left side of the hurricane path. Beach erosion and prominent overwash fans were observed throughout much of the field investigation area. The post-storm damage survey served to confirm expected performance under extreme conditions, as well as to evaluate recent development trends and conditions unique to each storm. Hurricane Ike confirmed many previously reported observations. One of the main conclusions from the inspection of buildings was that elevation was a key determinant for survival. Elevation is also a major factor in the stability and effectiveness of shore protection. The Galveston Seawall was high enough to provide protection from

  3. Worldwide historical hurricane tracks from 1848 through the previous hurricane season

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Historical Hurricane Tracks web site provides visualizations of storm tracks derived from the 6-hourly (0000, 0600, 1200, 1800 UTC) center locations and...

  4. [The importance of ADAM family proteins in malignant tumors].

    Science.gov (United States)

    Walkiewicz, Katarzyna; Gętek, Monika; Muc-Wierzgoń, Małgorzata; Kokot, Teresa; Nowakowska-Zajdel, Ewa

    2016-02-11

    Increasing numbers of reports about the role of adamalysins (ADAM) in malignant tumors are being published. To date, more than 30 representatives of this group, out of which about 20 occur in humans, have been described. The ADAM family is a homogeneous group of proteins which regulate, from the stage of embryogenesis, a series of processes such as cell migration, adhesion, and cell fusion. Half of them have proteolytic activity and are involved in the degradation of the extracellular matrix and the disintegration of certain protein complexes, thereby regulating the bioavailability of various growth factors. Many of these functions have a direct role in the processes of carcinogenesis and promoting the growth of tumor, which affect some signaling pathways, including those related to insulin-like growth factors (IGF1, IGF2), vascular growth factor (VEGF), tumor necrosis factor α (TNFα) and the EGFR/HER pathway. Another branch of studies is the evaluation of the possibility of using members of ADAM family proteins in the diagnosis, especially in breast, colon and non- small cell lung cancer. The detection of concentrations of adamalysin in serum, urine and pleural aspirates might contribute to the development of methods of early diagnosis of cancer and monitoring the therapy. However, both the role of adamalysins in the development and progression of tumors and their importance as a diagnostic and predictive further research still need to be checked on large groups of patients.

  5. ADAM33, a new candidate for psoriasis susceptibility.

    Directory of Open Access Journals (Sweden)

    Fabienne Lesueur

    Full Text Available Psoriasis is a chronic skin disorder with multifactorial etiology. In a recent study, we reported results of a genome-wide scan on 46 French extended families presenting with plaque psoriasis. In addition to unambiguous linkage to the major susceptibility locus PSORS1 on Chromosome 6p21, we provided evidence for a susceptibility locus on Chromosome 20p13. To follow up this novel psoriasis susceptibility locus we used a family-based association test (FBAT for an association scan over the 17 Mb candidate region. A total of 85 uncorrelated SNP markers located in 65 genes of the region were initially investigated in the same set of large families used for the genome wide search, which consisted of 295 nuclear families. When positive association was obtained for a SNP, candidate genes nearby were explored more in detail using a denser set of SNPs. Thus, the gene ADAM33 was found to be significantly associated with psoriasis in this family set (The best association was on a 3-SNP haplotype P = 0.00004, based on 1,000,000 permutations. This association was independent of PSORS1. ADAM33 has been previously associated with asthma, which demonstrates that immune system diseases may be controlled by common susceptibility genes with general effects on dermal inflammation and immunity. The identification of ADAM33 as a psoriasis susceptibility gene identified by positional cloning in an outbred population should provide insights into the pathogenesis and natural history of this common disease.

  6. 研华精巧型以太网络通讯控制器——ADAM-4501&ADAM-4501D

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    研华所提供通讯控制器特点是具备以太网络转串行的强大通讯功能,产品系列可依操作系统分成两大类:ROM—DOS的ADAM-4500控制器及Windows CE的ADAM-6501控制器。现在推出的ADAM-4501/4501D则是ADAM-4500控制器的下一代,除了内存容量增加之外,及提供更丰富的输出入接口,ADAM-4501D还提供一个5位数的使用者自订LED显示屏,能够在组件的表面显示自订功能状态。

  7. Hurricane Charley Exposure and Hazard of Preterm Delivery, Florida 2004.

    Science.gov (United States)

    Grabich, Shannon C; Robinson, Whitney R; Engel, Stephanie M; Konrad, Charles E; Richardson, David B; Horney, Jennifer A

    2016-12-01

    Objective Hurricanes are powerful tropical storm systems with high winds which influence many health effects. Few studies have examined whether hurricane exposure is associated with preterm delivery. We aimed to estimate associations between maternal hurricane exposure and hazard of preterm delivery. Methods We used data on 342,942 singleton births from Florida Vital Statistics Records 2004-2005 to capture pregnancies at risk of delivery during the 2004 hurricane season. Maternal exposure to Hurricane Charley was assigned based on maximum wind speed in maternal county of residence. We estimated hazards of overall preterm delivery (<37 gestational weeks) and extremely preterm delivery (<32 gestational weeks) in Cox regression models, adjusting for maternal/pregnancy characteristics. To evaluate heterogeneity among racial/ethnic subgroups, we performed analyses stratified by race/ethnicity. Additional models investigated whether exposure to multiples hurricanes increased hazard relative to exposure to one hurricane. Results Exposure to wind speeds ≥39 mph from Hurricane Charley was associated with a 9 % (95 % CI 3, 16 %) increase in hazard of extremely preterm delivery, while exposure to wind speed ≥74 mph was associated with a 21 % (95 % CI 6, 38 %) increase. Associations appeared greater for Hispanic mothers compared to non-Hispanic white mothers. Hurricane exposure did not appear to be associated with hazard of overall preterm delivery. Exposure to multiple hurricanes did not appear more harmful than exposure to a single hurricane. Conclusions Hurricane exposure may increase hazard of extremely preterm delivery. As US coastal populations and hurricane severity increase, the associations between hurricane and preterm delivery should be further studied.

  8. Hurricane names: A bunch of hot air?

    Directory of Open Access Journals (Sweden)

    Gary Smith

    2016-06-01

    Full Text Available It has been argued that female-named hurricanes are deadlier because people do not take them seriously. However, this conclusion is based on a questionable statistical analysis of a narrowly defined data set. The reported relationship is not robust in that it is not confirmed by a straightforward analysis of more inclusive data or different data.

  9. Wind and waves in extreme hurricanes

    NARCIS (Netherlands)

    Holthuijsen, L.H.; Powell, M.D.; Pietrzak, J.D.

    2012-01-01

    Waves breaking at the ocean surface are important to the dynamical, chemical and biological processes at the air-sea interface. The traditional view is that the white capping and aero-dynamical surface roughness increase with wind speed up to a limiting value. This view is fundamental to hurricane

  10. Economic impacts of hurricanes on forest owners

    Science.gov (United States)

    Jeffrey P. Prestemon; Thomas P. Holmes

    2010-01-01

    We present a conceptual model of the economic impacts of hurricanes on timber producers and consumers, offer a framework indicating how welfare impacts can be estimated using econometric estimates of timber price dynamics, and illustrate the advantages of using a welfare theoretic model, which includes (1) welfare estimates that are consistent with neo-classical...

  11. Investigation of long-term hurricane activity

    NARCIS (Netherlands)

    Nguyen, B.M.; Van Gelder, P.H.A.J.M.

    2012-01-01

    This paper presents a new approach of applying numerical methods to model storm processes. A storm empirical track technique is utilized to simulate the full tracks of hurricanes, starting with their initial points over the sea and ending with their landfall locations or final dissipations. The

  12. Hurricane Ike versus an Atomic Bomb

    Science.gov (United States)

    Pearson, Earl F.

    2013-01-01

    The destructive potential of one of nature's most destructive forces, the hurricane, is compared to one of human's most destructive devices, an atomic bomb. Both can create near absolute devastation at "ground zero". However, how do they really compare in terms of destructive energy? This discussion compares the energy, the…

  13. Rapid mapping of hurricane damage to forests

    Science.gov (United States)

    Erik M. Nielsen

    2009-01-01

    The prospects for producing rapid, accurate delineations of the spatial extent of forest wind damage were evaluated using Hurricane Katrina as a test case. A damage map covering the full spatial extent of Katrina?s impact was produced from Moderate Resolution Imaging Spectroradiometer (MODIS) satellite imagery using higher resolution training data. Forest damage...

  14. The economics and ethics of Hurricane Katrina.

    Science.gov (United States)

    Rockwell, Llewellyn H; Block, Walter E

    2010-01-01

    How might free enterprise have dealt with Hurricane Katrina and her aftermath. This article probes this question at increasing levels of radicalization, starting with the privatization of several government “services” and ending with the privatization of all of them.

  15. Gulf Coast Hurricanes Situation Report #40

    Energy Technology Data Exchange (ETDEWEB)

    None

    2005-11-14

    On 11/12 Florida Power & Light (FPL) announced that crews had essentially completed Hurricane Wilma restoration efforts to all 3.2 million customers in South Florida who had been without power. Electricity restoration efforts are now essentially complete in Florida.

  16. Hurricanes as Heat Engines: Two Undergraduate Problems

    Science.gov (United States)

    Pyykko, Pekka

    2007-01-01

    Hurricanes can be regarded as Carnot heat engines. One reason that they can be so violent is that thermodynamically, they demonstrate large efficiency, [epsilon] = (T[subscript h] - T[subscript c]) / T[subscript h], which is of the order of 0.3. Evaporation of water vapor from the ocean and its subsequent condensation is the main heat transfer…

  17. Evacuating the Area of a Hurricane

    Centers for Disease Control (CDC) Podcasts

    2006-08-10

    If a hurricane warning is issued for your area, or authorities tell you to evacuate, take only essential items. If you have time, turn off gas, electricity, and water and disconnect appliances.  Created: 8/10/2006 by Emergency Communications System.   Date Released: 10/10/2007.

  18. Wind and waves in extreme hurricanes

    NARCIS (Netherlands)

    Holthuijsen, L.H.; Powell, M.D.; Pietrzak, J.D.

    2012-01-01

    Waves breaking at the ocean surface are important to the dynamical, chemical and biological processes at the air-sea interface. The traditional view is that the white capping and aero-dynamical surface roughness increase with wind speed up to a limiting value. This view is fundamental to hurricane f

  19. Wind and waves in extreme hurricanes

    NARCIS (Netherlands)

    Holthuijsen, L.H.; Powell, M.D.; Pietrzak, J.D.

    2012-01-01

    Waves breaking at the ocean surface are important to the dynamical, chemical and biological processes at the air-sea interface. The traditional view is that the white capping and aero-dynamical surface roughness increase with wind speed up to a limiting value. This view is fundamental to hurricane f

  20. Investigation of long-term hurricane activity

    NARCIS (Netherlands)

    Nguyen, B.M.; Van Gelder, P.H.A.J.M.

    2012-01-01

    This paper presents a new approach of applying numerical methods to model storm processes. A storm empirical track technique is utilized to simulate the full tracks of hurricanes, starting with their initial points over the sea and ending with their landfall locations or final dissipations. The theo

  1. Preparing for a Hurricane: Prescription Medications

    Centers for Disease Control (CDC) Podcasts

    2006-08-10

    What you should do to protect yourself and your family from a hurricane. As you evacuate, remember to take your prescription medicines with you.  Created: 8/10/2006 by Emergency Communications System.   Date Released: 7/17/2008.

  2. Hurricane Ike versus an Atomic Bomb

    Science.gov (United States)

    Pearson, Earl F.

    2013-01-01

    The destructive potential of one of nature's most destructive forces, the hurricane, is compared to one of human's most destructive devices, an atomic bomb. Both can create near absolute devastation at "ground zero". However, how do they really compare in terms of destructive energy? This discussion compares the energy, the…

  3. Elements of extreme wind modeling for hurricanes

    DEFF Research Database (Denmark)

    Larsen, Søren Ejling; Ejsing Jørgensen, Hans; Kelly, Mark C.;

    The report summarizes characteristics of the winds associated with Tropical Cyclones (Hurricanes, Typhoons). It has been conducted by the authors across several years, from 2012-2015, to identify the processes and aspects that one should consider when building at useful computer support system...

  4. A semiotic interpretation of national typology: the English, the Boers and ... the Russians (Ivan Goncharov’s Frigate Pallas

    Directory of Open Access Journals (Sweden)

    H. Mondry

    1991-05-01

    Full Text Available This article examines the text of renowned nineteenth century Russian travellers notes, The Frigate Pallada, by Ivan Goncharov, the author of Oblomov. Using the teachings of Victor Shklovsky, Yurij Tynianov and Yurij Lotman on the role of the genre of travellers notes in the history of Russian literature, the author examines the chapter on the Cape Province. She demonstrates that in his descriptions of the two nations of the Cape Province - the English and the Boers - Goncharov is applying that which is known to him - his own cultural model of the Russian society of the mid-nineteenth century. In his examination of differences between the English and the Boers Goncharov applies the ideological dichotomy between the Slavophiles and the Westernisers. Goncharov, by "inverting" the "dual model of Russian culture" (Lotman & Uspensky, 1984a draws comparisons between the Russians of the Oblomov Slavophile type on the one hand, and the English on the other hand as the model for the improvement of the industry of the economically backward Russian nation. To Goncharov the Boers resemble the Oblomov, old world side of dichotomy, which by inversions of the dual model can fluctuate between "the good" and "the bad" categories.

  5. Santiago Ramón y Cajal and Ivan Petrovic Pavlov: their parallel scientific lives, Schools and Nobel Prizes

    Directory of Open Access Journals (Sweden)

    Jairo Alonso Rozo

    2015-06-01

    Full Text Available Santiago Ramón y Cajal was not only a great scientist but he was also a dedicated teacher who managed to create his own School in Spain. Cajal was active at the end of the XIX and the beginning of the XX century, a period in which Ivan Petrovich Pavlov, another great contemporary scientist, also established a strong School in Russia. While these two acclaimed scientists shared a similar vision on science, a view they also conveyed to their disciples, they applied quite distinct criteria in the way they dealt with their followers. Interestingly, despite the geographic and idiomatic barriers that had to be overcome, the paths of these two great figures of XX century science crossed at least three times. First when they competed for the City of Moscow Prize, second when they both attended the Congreso Internacional de Medicina de Madrid (Medicine International Congress in Madrid in 1903 and finally, they competed on four consecutive occasions for the Nobel Prize in Physiology or Medicine. Here we discuss their scientific vision, their different attitudes in the interaction with disciples and the distinct circumstances in which their paths crossed.

  6. Santiago Ramón y Cajal and Ivan Petrovic Pavlov: their parallel scientific lives, schools and nobel prizes.

    Science.gov (United States)

    Rozo, Jairo A; Rodríguez-Moreno, Antonio

    2015-01-01

    Santiago Ramón y Cajal was not only a great scientist but he was also a dedicated teacher who managed to create his own School in Spain. Cajal was active at the end of the XIX and the beginning of the XX century, a period in which Ivan Petrovich Pavlov, another great contemporary scientist, also established a strong School in Russia. While these two acclaimed scientists shared a similar vision on science, a view they also conveyed to their disciples, they applied quite distinct criteria in the way they dealt with their followers. Interestingly, despite the geographic and idiomatic barriers that had to be overcome, the paths of these two great figures of XX century science crossed at least three times. First when they competed for the City of Moscow Prize, second when they both attended the "Congreso Internacional de Medicina de Madrid" (Medicine International Congress in Madrid) in 1903 and finally, they competed on four consecutive occasions for the Nobel Prize in Physiology or Medicine. Here we discuss their scientific vision, their different attitudes in the interaction with disciples and the distinct circumstances in which their paths crossed.

  7. Lukisan Ivan Sagita “Makasih Kollwitz” (2005 dalam Sejarah Seni Lukis Modern Indonesia: Tinjauan Ikonografi dan Ikonologi

    Directory of Open Access Journals (Sweden)

    M. Agus Burhan

    2015-03-01

    Full Text Available Penelitian ini menganalisis karya seni lukis berjudul “Makasih Kollwitz” (2005, yang dilu- kis oleh Ivan Sagita. Dengan menggunakan sejarah seni sebagai dasar pendekatan, selanjutnya pilihan teori utama yang dipakai adalah teori ikonografi dan ikonologi Erwin Panofsky. Metode penelitian sejarah meliputi, pencarian data di lapangan dan sumber-sumber pustaka, seleksi dan kritik data, analisis dan interpretasi data untuk menghasilkan sintesis, selanjutnya penyu- sunan historiografi atau laporan penelitian sejarah. Hasil penelitian ini berisi, deskripsi pra iko- nografi yang menerangkan tahap awal aspek ide tekstual, yaitu menggambarkan sosok wanita tua renta mengambang di langit, terbaring dengan beralaskan rambutnya yang memanjang melampaui tubuhnya. Nenek itu sedang dalam proses kematian. Analisis ikonografi menjelas- kan tentang tema dan konsep. Hal itu mengungkapkan tema fenomena kematian, dengan ru- jukan konsep dasar tentang kefanaan hidup dan nilai survival eksistensi kehidupan manusia. Interpretasi ikonologi menjelaskan nilai simbolis pada karya. Melalui pengalaman kejiwaan dan latar belakang sosial dan kebudayaan seniman, terungkap bahwa lukisan ini merupakan kristalisasi simbol tentang kontradiksi dalam eksistensi kehidupan manusia.       Kata kunci: Surrealisme, kematian,  kontradiksi, eksistensi

  8. Atlantic Hurricane Activity: 1851-1900

    Science.gov (United States)

    Landsea, C. W.

    2001-12-01

    This presentation reports on the second year's work of a three year project to re-analyze the North Atlantic hurricane database (or HURDAT). The original database of six-hourly positions and intensities were put together in the 1960s in support of the Apollo space program to help provide statistical track forecast guidance. In the intervening years, this database - which is now freely and easily accessible on the Internet from the National Hurricane Center's (NHC's) Webpage - has been utilized for a wide variety of uses: climatic change studies, seasonal forecasting, risk assessment for county emergency managers, analysis of potential losses for insurance and business interests, intensity forecasting techniques and verification of official and various model predictions of track and intensity. Unfortunately, HURDAT was not designed with all of these uses in mind when it was first put together and not all of them may be appropriate given its original motivation. One problem with HURDAT is that there are numerous systematic as sell as some random errors in the database which need correction. Additionally, analysis techniques have changed over the years at NHC as our understanding of tropical cyclones has developed, leading to biases in the historical database that have not been addressed. Another difficulty in applying the hurricane database to studies concerned with landfalling events is the lack exact location, time and intensity at hurricane landfall. Finally, recent efforts into uncovering undocumented historical hurricanes in the late 1800s and early 1900s led by Jose Fernandez-Partagas have greatly increased our knowledge of these past events, which are not yet incorporated into the HURDAT database. Because of all of these issues, a re-analysis of the Atlantic hurricane database is being attempted that will be completed in three years. As part of the re-analyses, three files will be made available: {* } The revised Atlantic HURDAT (with six hourly intensities

  9. ADAM12-S stimulates bone growth in transgenic mice by modulating chondrocyte proliferation and maturation

    DEFF Research Database (Denmark)

    Kveiborg, Marie; Albrechtsen, Reidar; Rudkjaer, Lise

    2006-01-01

    ADAM12-S transgenic mice exhibit a pronounced increase in the length of bones, such as femur, tibia, and vertebrae. The effect of ADAM12-S on longitudinal bone growth involves the modulation of chondrocyte proliferation and maturation, likely through proteolytic activities and altered cell......-extracellular matrix interactions in the growth plate. INTRODUCTION: The disintegrin and metalloprotease ADAM12 is expressed in both osteoblasts and osteoclasts, suggesting a regulatory role of ADAM12 in bone. However, thus far, no in vivo function of ADAM12 in the skeleton has been reported. MATERIALS AND METHODS......-extracellular matrix interactions. RESULTS: ADAM12-S transgenic mice exhibit increased longitudinal bone growth. The increased bone length is progressive and age dependent, with a maximum increase of 17% seen in the femur from 6-month-old transgenic mice. The effect is gene dose dependent, being more pronounced...

  10. Transgenic overexpression of ADAM12 suppresses muscle regeneration and aggravates dystrophy in aged mdx mice

    DEFF Research Database (Denmark)

    Jørgensen, Louise Helskov; Jensen, Charlotte Harken; Wewer, Ulla M;

    2007-01-01

    Muscular dystrophies are characterized by insufficient restoration and gradual replacement of the skeletal muscle by fat and connective tissue. ADAM12 has previously been shown to alleviate the pathology of young dystrophin-deficient mdx mice, a model for Duchenne muscular dystrophy. The observed...... effect of ADAM12 was suggested to be mediated via a membrane-stabilizing up-regulation of utrophin, alpha7B integrin, and dystroglycans. Ectopic ADAM12 expression in normal mouse skeletal muscle also improved regeneration after freeze injury, presumably by the same mechanism. Hence, it was suggested...... overexpressing ADAM12 (ADAM12(+)/mdx mice), even though their utrophin levels were mildly elevated compared with age-matched controls. Thus, membrane stabilization was not sufficient to provide protection during prolonged disease. Consequently, we reinvestigated skeletal muscle regeneration in ADAM12 transgenic...

  11. Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus α-toxin action.

    Science.gov (United States)

    von Hoven, Gisela; Rivas, Amable J; Neukirch, Claudia; Klein, Stefan; Hamm, Christian; Qin, Qianqian; Meyenburg, Martina; Füser, Sabine; Saftig, Paul; Hellmann, Nadja; Postina, Rolf; Husmann, Matthias

    2016-07-01

    Staphylococcus aureus is a leading cause of bacterial infections in humans, including life-threatening diseases such as pneumonia and sepsis. Its small membrane-pore-forming α-toxin is considered an important virulence factor. By destroying cell-cell contacts through cleavage of cadherins, the metalloproteinase ADAM10 (a disintegrin and metalloproteinase 10) critically contributes to α-toxin-dependent pathology of experimental S. aureus infections in mice. Moreover, ADAM10 was proposed to be a receptor for α-toxin. However, it is unclear whether the catalytic activity or specific domains of ADAM10 are involved in mediating binding and/or subsequent cytotoxicity of α-toxin. Also, it is not known how α-toxin triggers ADAM10's enzymatic activity, and whether ADAM10 is invariably required for all α-toxin action on cells. In the present study, we show that efficient cleavage of the ADAM10 substrate epithelial cadherin (E-cadherin) requires supra-cytotoxic concentrations of α-toxin, leading to significant increases in intracellular [Ca(2+)]; the fall in cellular ATP levels, typically following membrane perforation, became observable at far lower concentrations. Surprisingly, ADAM10 was dispensable for α-toxin-dependent xenophagic targeting of S. aureus, whereas a role for α-toxin attack on the plasma membrane was confirmed. The catalytic site of ADAM10, furin cleavage site, cysteine switch and intracellular domain of ADAM10 were not required for α-toxin binding and subsequent cytotoxicity. In contrast, an essential role for the disintegrin domain and the prodomain emerged. Thus, co-expression of the prodomain with prodomain-deficient ADAM10 reconstituted binding of α-toxin and susceptibility of ADAM10-deficient cells. The results of the present study may help to inform structural analyses of α-toxin-ADAM10 interactions and to design novel strategies to counteract S. aureus α-toxin action.

  12. Conservation and divergence of ADAM family proteins in the Xenopus genome

    Directory of Open Access Journals (Sweden)

    Shah Anoop

    2010-07-01

    Full Text Available Abstract Background Members of the disintegrin metalloproteinase (ADAM family play important roles in cellular and developmental processes through their functions as proteases and/or binding partners for other proteins. The amphibian Xenopus has long been used as a model for early vertebrate development, but genome-wide analyses for large gene families were not possible until the recent completion of the X. tropicalis genome sequence and the availability of large scale expression sequence tag (EST databases. In this study we carried out a systematic analysis of the X. tropicalis genome and uncovered several interesting features of ADAM genes in this species. Results Based on the X. tropicalis genome sequence and EST databases, we identified Xenopus orthologues of mammalian ADAMs and obtained full-length cDNA clones for these genes. The deduced protein sequences, synteny and exon-intron boundaries are conserved between most human and X. tropicalis orthologues. The alternative splicing patterns of certain Xenopus ADAM genes, such as adams 22 and 28, are similar to those of their mammalian orthologues. However, we were unable to identify an orthologue for ADAM7 or 8. The Xenopus orthologue of ADAM15, an active metalloproteinase in mammals, does not contain the conserved zinc-binding motif and is hence considered proteolytically inactive. We also found evidence for gain of ADAM genes in Xenopus as compared to other species. There is a homologue of ADAM10 in Xenopus that is missing in most mammals. Furthermore, a single scaffold of X. tropicalis genome contains four genes encoding ADAM28 homologues, suggesting genome duplication in this region. Conclusions Our genome-wide analysis of ADAM genes in X. tropicalis revealed both conservation and evolutionary divergence of these genes in this amphibian species. On the one hand, all ADAMs implicated in normal development and health in other species are conserved in X. tropicalis. On the other hand, some

  13. ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice

    Directory of Open Access Journals (Sweden)

    Lakshini Weerasekera

    2017-01-01

    Full Text Available Obesity is one of the most prevalent metabolic diseases in the Western world and correlates directly with insulin resistance, which may ultimately culminate in type 2 diabetes (T2D. We sought to ascertain whether the human metalloproteinase A Disintegrin and Metalloproteinase 19 (ADAM19 correlates with parameters of the metabolic syndrome in humans and mice. To determine the potential novel role of ADAM19 in the metabolic syndrome, we first conducted microarray studies on peripheral blood mononuclear cells from a well-characterised human cohort. Secondly, we examined the expression of ADAM19 in liver and gonadal white adipose tissue using an in vivo diet induced obesity mouse model. Finally, we investigated the effect of neutralising ADAM19 on diet induced weight gain, insulin resistance in vivo, and liver TNF-α levels. Significantly, we show that, in humans, ADAM19 strongly correlates with parameters of the metabolic syndrome, particularly BMI, relative fat, HOMA-IR, and triglycerides. Furthermore, we identified that ADAM19 expression was markedly increased in the liver and gonadal white adipose tissue of obese and T2D mice. Excitingly, we demonstrate in our diet induced obesity mouse model that neutralising ADAM19 therapy results in weight loss, improves insulin sensitivity, and reduces liver TNF-α levels. Our novel data suggest that ADAM19 is pro-obesogenic and enhances insulin resistance. Therefore, neutralisation of ADAM19 may be a potential therapeutic approach to treat obesity and T2D.

  14. ADAM10 is essential for cranial neural crest-derived maxillofacial bone development

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Yu, E-mail: tanyu2048@163.com; Fu, Runqing, E-mail: furunqing@sjtu.edu.cn; Liu, Jiaqiang, E-mail: liujqmj@163.com; Wu, Yong, E-mail: wyonger@gmail.com; Wang, Bo, E-mail: wb228@126.com; Jiang, Ning, E-mail: 179639060@qq.com; Nie, Ping, E-mail: nieping1011@sina.com; Cao, Haifeng, E-mail: 0412chf@163.com; Yang, Zhi, E-mail: wcums1981@163.com; Fang, Bing, E-mail: fangbing@sjtu.edu.cn

    2016-07-08

    Growth disorders of the craniofacial bones may lead to craniofacial deformities. The majority of maxillofacial bones are derived from cranial neural crest cells via intramembranous bone formation. Any interruption of the craniofacial skeleton development process might lead to craniofacial malformation. A disintegrin and metalloprotease (ADAM)10 plays an essential role in organ development and tissue integrity in different organs. However, little is known about its function in craniofacial bone formation. Therefore, we investigated the role of ADAM10 in the developing craniofacial skeleton, particularly during typical mandibular bone development. First, we showed that ADAM10 was expressed in a specific area of the craniofacial bone and that the expression pattern dynamically changed during normal mouse craniofacial development. Then, we crossed wnt1-cre transgenic mice with adam10-flox mice to generate ADAM10 conditional knockout mice. The stereomicroscopic, radiographic, and von Kossa staining results showed that conditional knockout of ADAM10 in cranial neural crest cells led to embryonic death, craniofacial dysmorphia and bone defects. Furthermore, we demonstrated that impaired mineralization could be triggered by decreased osteoblast differentiation, increased cell death. Overall, these findings show that ADAM10 plays an essential role in craniofacial bone development. -- Highlights: •We firstly reported that ADAM10 was essentially involved in maxillofacial bone development. •ADAM10 cKO mice present craniofacial dysmorphia and bone defects. •Impaired osteoblast differentiation,proliferation and apoptosis underlie the bone deformity.

  15. ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3

    DEFF Research Database (Denmark)

    Loechel, F; Fox, J W; Murphy, G;

    2000-01-01

    that it cleaves insulin-like growth factor binding protein-3 (IGFBP-3). This result supports a role for ADAM 12-S in the degradation of IGFBP-3 in the blood of pregnant women. Furthermore, we tested for proteolysis of other members of the IGF binding protein family and found that ADAM 12-S cleaves IGFBP-5......ADAMs are a family of multidomain proteins having proteolytic and cell adhesion activities. We have previously shown that ADAM 12-S, the secreted soluble form of human ADAM 12, is a catalytically active protease. We now describe the purification of full-length recombinant ADAM 12-S and demonstrate...... in addition to IGFBP-3, but does not cleave IGFBP-1, -2, -4, or -6. ADAM 12-S may therefore be the IGFBP-5 protease that is secreted by osteoblasts and other cells. Cleavage of both IGFBP-3 and -5 by ADAM 12-S was inhibited by TIMP-3, raising the possibility that TIMP-3 is a physiological inhibitor of ADAM 12...

  16. Adam Olearius ja kultuuriline Teine teekonnal Oktsidendist Orienti / Aigi Heero, Maris Saagpakk

    Index Scriptorium Estoniae

    Heero, Aigi, 1971-

    2013-01-01

    Erinevate rahvaste kujutamisest 1656. aastal ilmunud Adam Oleariuse tuntud varauusaegses reisikirjas "Vermehrte Newe Beschreibung Der Muscowitischen vnd Persischen Reyse". Eestlaste kujutamisest võrdluses teiste rahvastega

  17. Increase of α-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging.

    Science.gov (United States)

    Schuck, Florian; Wolf, Dominik; Fellgiebel, Andreas; Endres, Kristina

    2016-01-01

    ADAM10 is one of the key players in ectodomain-shedding of the amyloid-β protein precursor (AβPP). Previous research with postmortem tissue has shown reduced expression and activity of ADAM10 within the central nervous system (CNS) of Alzheimer's disease (AD) patients. Determination of cerebral ADAM10 in living humans is hampered by its transmembrane property; only the physiological AβPP cleavage product generated by ADAM10, sAβPPα, can be assessed in cerebrospinal fluid. Establishment of surrogate markers in easily accessible material therefore is crucial. It has been demonstrated that ADAM10 is expressed in platelets and that platelet amount is decreased in AD patients. Just recently it has been shown that platelet ADAM10 and cognitive performance of AD patients positively correlate. In contrast to AD patients, to our knowledge almost no information has been published regarding ADAM10 expression during normal aging. We investigated ADAM10 amount and activity in platelets of cognitively healthy individuals from three different age groups ranging from 22-85 years. Interestingly, we observed an age-dependent increase in ADAM10 levels and activity in platelets.

  18. ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation

    DEFF Research Database (Denmark)

    Lafuste, Peggy; Sonnet, Corinne; Chazaud, Bénédicte

    2005-01-01

    Knowledge on molecular systems involved in myogenic precursor cell (mpc) fusion into myotubes is fragmentary. Previous studies have implicated the a disintegrin and metalloproteinase (ADAM) family in most mammalian cell fusion processes. ADAM12 is likely involved in fusion of murine mpc and human...... extracellular matrix, suggesting specific involvement of ADAM12-alpha9beta1 interaction in the fusion process. Evaluation of the fusion rate with regard to the size of myotubes showed that both ADAM12 antisense oligonucleotides and alpha9beta1 blockade inhibited more importantly formation of large (> or =5...

  19. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries.

    Science.gov (United States)

    Poindexter, K; Nelson, N; DuBose, R F; Black, R A; Cerretti, D P

    1999-09-03

    Metalloproteinase-disintegrins (ADAMs) are membrane-spanning multi-domain proteins containing a zinc metalloproteinase domain and a disintegrin domain which may serve as an integrin ligand. Based on a conserved sequence within the disintegrin domain, GE(E/Q)CDCG, seven genes were isolated from a human genomic library. Two of these genes lack introns and show testis-specific expression (ADAM20 and ADAM21), while the other two genes contain introns (ADAM22 and ADAM23) and are expressed predominantly in the brain. In addition, three pseudogenes were isolated; one of which evolved from ADAM21. Human chromosomal mapping indicated that ADAM22 and ADAM23 mapped to chromosome 7q21 and 2q33, respectively, while the three pseudogenes 1-2, 3-3, and 1-32 mapped to chromosome 14q24.1, 8p23, and 14q24.1, respectively. An ancestral analysis of all known ADAMs indicates that the zinc-binding motif in the catalytic domain arose once in a common ancestor and was lost by those members lacking this motif.

  20. ADAM10 Is Involved in Cell Junction Assembly in Early Porcine Embryo Development.

    Directory of Open Access Journals (Sweden)

    Jeongwoo Kwon

    Full Text Available ADAM10 (A Disintegrin and Metalloprotease domain-containing protein 10 is a cell surface protein with a unique structure possessing both potential adhesion and protease domains. However, the role of ADAM10 in preimplantation stage embryos is not clear. In this study, we examined the expression patterns and functional roles of ADAM10 in porcine parthenotes during preimplantation development. The transcription level of ADAM10 dramatically increased from the morula stage onward. Immunostaining revealed that ADAM10 was present in both the nucleus and cytoplasm in early cleavage stage embryos, and localized to the apical region of the outer cells in morula and blastocyst embryos. Knockdown (KD of ADAM10 using double strand RNA did not alter preimplantation embryo development until morula stage, but resulted in significantly reduced development to blastocyst stage. Moreover, the KD blastocyst showed a decrease in gene expression of adherens and tight junction (AJ/TJ, and an increase in trophectoderm TJ permeability by disrupting TJ assembly. Treatment with an ADAM10 specific chemical inhibitor, GI254023X, at the morula stage also inhibited blastocyst development and led to disruption of TJ assembly. An in situ proximity ligation assay demonstrated direct interaction of ADAM10 with coxsackie virus and adenovirus receptor (CXADR, supporting the involvement of ADAM10 in TJ assembly. In conclusion, our findings strongly suggest that ADADM10 is important for blastocyst formation rather than compaction, particularly for TJ assembly and stabilization in preimplantation porcine parthenogenetic development.

  1. Adam Olearius ja kultuuriline Teine teekonnal Oktsidendist Orienti / Aigi Heero, Maris Saagpakk

    Index Scriptorium Estoniae

    Heero, Aigi, 1971-

    2013-01-01

    Erinevate rahvaste kujutamisest 1656. aastal ilmunud Adam Oleariuse tuntud varauusaegses reisikirjas "Vermehrte Newe Beschreibung Der Muscowitischen vnd Persischen Reyse". Eestlaste kujutamisest võrdluses teiste rahvastega

  2. John Adams's Montesquieuean Moment: Enlightened Historicism in the Discourses on Davila.

    Science.gov (United States)

    Green, Jonathan

    2016-01-01

    At the outset of the French Revolution John Adams penned a series of Discourses of Davila, philosophical ruminations on the sixteenth-century French Wars of Religion. Recent historians have read these Discourses in terms of Adams's Machiavellianism-his conviction that men's passions lead to violence, if unrestrained. But this reading overlooks the extent to which Adams intended his Discourses as a particular investigation into the French nation's character, and into whether the revolutionaries could lay claim to a native, French tradition of mixed constitutional government. Situating the Discourses vis-à-vis Adams's contemporaneous reading of Montesquieu, this article argues for an underappreciated historicist dimension to his thought.

  3. Mapping and Visualization of Storm-Surge Dynamics for Hurricane Katrina and Hurricane Rita

    Science.gov (United States)

    Gesch, Dean B.

    2009-01-01

    The damages caused by the storm surges from Hurricane Katrina and Hurricane Rita were significant and occurred over broad areas. Storm-surge maps are among the most useful geospatial datasets for hurricane recovery, impact assessments, and mitigation planning for future storms. Surveyed high-water marks were used to generate a maximum storm-surge surface for Hurricane Katrina extending from eastern Louisiana to Mobile Bay, Alabama. The interpolated surface was intersected with high-resolution lidar elevation data covering the study area to produce a highly detailed digital storm-surge inundation map. The storm-surge dataset and related data are available for display and query in a Web-based viewer application. A unique water-level dataset from a network of portable pressure sensors deployed in the days just prior to Hurricane Rita's landfall captured the hurricane's storm surge. The recorded sensor data provided water-level measurements with a very high temporal resolution at surveyed point locations. The resulting dataset was used to generate a time series of storm-surge surfaces that documents the surge dynamics in a new, spatially explicit way. The temporal information contained in the multiple storm-surge surfaces can be visualized in a number of ways to portray how the surge interacted with and was affected by land surface features. Spatially explicit storm-surge products can be useful for a variety of hurricane impact assessments, especially studies of wetland and land changes where knowledge of the extent and magnitude of storm-surge flooding is critical.

  4. 78 FR 32296 - Second Allocation of Public Transportation Emergency Relief Funds in Response to Hurricane Sandy...

    Science.gov (United States)

    2013-05-29

    ... Response to Hurricane Sandy: Response, Recovery & Resiliency AGENCY: Federal Transit Administration (FTA... recipients most severely affected by Hurricane Sandy: the Metropolitan Transportation Authority, New Jersey... Federal Register notice, bringing the total amount of Hurricane Sandy Emergency Relief funds allocated...

  5. ADAM33 gene polymorphisms in chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Pabst S

    2009-12-01

    Full Text Available Abstract Study objective The pathogenesis of chronic obstructive pulmonary disease (COPD is characterized by an interaction of environmental influences, particularly cigarette smoking, and genetic determinants. Given the global increase in COPD, research on the genomic variants that affect susceptibility to this complex disorder is reviving. In the present study, we investigated whether single nucleotide polymorphisms in 'a disinter-grin and metalloprotease' 33 (ADAM33 are associated with the development and course of COPD. Patients and design We genotyped 150 German COPD patients and 152 healthy controls for the presence of the F+1 and S_2 SNPs in ADAM 33 that lead to the base pair exchange G to A and C to G, respectively. To assess whether these genetic variants are influential in the course of COPD, we subdivided the cohort into two subgroups comprising 60 patients with a stable and 90 patients with an unstable course of disease. Results In ADAM33, the frequency of the F+1 A allele was 35.0% among stable and 43.9% among unstable COPD subjects, which was not significantly different from the 35.5% found in the controls (P = 0.92 and P = 0.07, respectively. The frequency of the S_2 mutant allele in subjects with a stable COPD was 23.3% (P = 0.32, in subjects with an unstable course 30.6% (P = 0.47. Conclusion The study shows that there is no significant difference in the distribution of the tested SNPs between subjects with and without COPD. Furthermore, these polymorphisms appear to have no consequences for the stability of the disease course.

  6. Simulation of Naval Guns' Breechblock System Dynamics Based on ADAMS

    Science.gov (United States)

    Tan, Bo; Liu, Hui-Min; Liu, Kai

    In order to study the dynamical characteristics of the breechblock system during gun firing, a virtual prototype model was established based on ADAMS, in which motion and force transmission among mechanisms are realized by collision. By simulation, kinematics and dynamics properties of main components are obtained, and the relationships between the motion of breechblock and the position of breechblock opening plate are analyzed. According to the simulation results, the collision among the breechblock opening plate and the roller is discontinuous, which may make the breechblock system fail to hitch the breechblock reliably. And within allowable scope of the structure, the breechblock opening template should be installed near the upside as much as possible.

  7. ADAMS-MATLAB Co-Simulation of A Serial Manipulator

    Directory of Open Access Journals (Sweden)

    Parthasarathy Tejaswin

    2017-01-01

    Full Text Available This paper presents the dynamic modelling and simulation of a now redundant robot, Mitsubishi RM-501, and proposes a general algorithm for experimental simulation in kinematics, dynamics and control analysis to any such robot. Through reverse engineering, a model as accurate as the real robot was developed in SolidWorks.The simulations of the same were performed in ADAMS (dynamicmodeling software offered by MSC Software Corpalong with MATLAB for motion studies and control dynamics. Finally, with a user-input path the accuracy and precision of the simulator was verified.

  8. Adam Smith et le “républicanisme”

    Directory of Open Access Journals (Sweden)

    Alexandra HYARD

    2003-10-01

    Full Text Available Je remercie Pierre Lurbe et Ann Thomson pour leurs remarques. Je tiens également à remercier Thierry Demals pour son aide précieuse. Néanmoins, je reste seule responsable des éventuelles erreurs contenues dans ce travail.Introduction Smith semble avoir toujours été en théorie un républicain, et il a sûrement eu le vrai esprit d’un républicain dans son amour de toute liberté rationnelle. (Rae 124 Par cette phrase, Rae nous livre son opinion sur une des questions relatives à Adam Smith (1723-1...

  9. Research on Fault Evaluation of Armament Equipment Based on ADAMS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The levels of simulation are introduced, and the importance of virtual prototyping of armament equipment is discussed and steps of virtual prototyping are outlined. The faults that affect firing performance are discussea, ADAMS is first to be introduced to armament equipment,and a virtual prototyping model of artillery is established with the help of Fortran language based on analysis of topology of artillery and forces applied on it. The plan of fault evaluation is brought forward, the modules are analyzed, and the concept of fault evaluation function is introduced Finally, the perspective of virtual technology is presented.

  10. Adam Smith y Sistemas Dinámicos

    OpenAIRE

    Acuña, Osvaldo; Ulate, Fernán

    2008-01-01

    Presentamos un sistema dinámico sencillo con dos ecuaciones diferenciales, una representa la trayectoria del precio y la otra la de la cantidad de un bien en una economía. Nuestro modelo se basa sobre todo en la teoría clásica de precios expuesta por Adam Smith en La Riqueza de las Naciones. Al final del trabajo, se presenta, a modo de ejemplo, un estudio para el caso del ganado vacuno en la economía mundial.

  11. ADAM17 is associated with EMMPRIN and predicts poor prognosis in patients with uterine cervical carcinoma.

    Science.gov (United States)

    Xu, Qin; Ying, Mingang; Chen, Guilin; Lin, Ang; Xie, Yunqing; Ohara, Noriyuki; Zhou, Dongmei

    2014-08-01

    Metalloproteinase activities of a disintegrin and metalloproteinase 17 (ADAM17), amphiregulin (AREG), extracellular matrix metalloproteinase inducer (EMMPRIN), and matrix metalloproteinases (MMPs) are involved in tumor biology. In patients with uterine cervical carcinoma, the expression and prognostic significance of ADAM17 remain to be fully elucidated. The expression of ADAM17, AREG, EMMPRIN, phospho-epidermal growth factor receptor (p-EGFR), phospho-extracellular signal-regulated kinase (p-ERK), MMP-2, and MMP-9 was assessed by immunohistochemistry and/or Western blotting from cervical carcinoma cell lines, SiHa and HeLa cells, and cervical carcinoma tissues. AREG activity was measured by ELISA assay. The correlation of ADAM17, AREG, EMMPRIN, and MMP-9 expression with patients' survival rates was assessed by Kaplan-Meier and Cox regression analyses. RNA interference (RNAi) experiment was performed using small interfering mRNA to ADAM17 and EMMPRIN. ADAM17, EMMPRIN, and MMP-9 protein content was overexpressed in cervical carcinoma tissues compared with normal cervical tissues (P cervical cancer. ADAM17 RNAi decreased EMMPRIN, p-EGFR, p-ERK, MMP-2, and MMP-9 proteins in SiHa and HeLa cells. ELISA assay revealed that AREG activity was stimulated by ADAM17 and was reversed by ADAM17 RNAi in SiHa and HeLa cells. Our data suggest that the increased expression of ADAM17 in cervical cancer is significantly associated with aggressive progression and poor prognosis. ADAM17 may be a molecular marker for predicting the progression and prognosis in cervical cancer.

  12. ADAM15 Is Functionally Associated with the Metastatic Progression of Human Bladder Cancer.

    Directory of Open Access Journals (Sweden)

    Guadalupe Lorenzatti Hiles

    Full Text Available ADAM15 is a member of a family of catalytically active disintegrin membrane metalloproteinases that function as molecular signaling switches, shed membrane bound growth factors and/or cleave and inactivate cell adhesion molecules. Aberrant metalloproteinase function of ADAM15 may contribute to tumor progression through the release of growth factors or disruption of cell adhesion. In this study, we utilized human bladder cancer tissues and cell lines to evaluate the expression and function of ADAM15 in the progression of human bladder cancer. Examination of genome and transcriptome databases revealed that ADAM15 ranked in the top 5% of amplified genes and its mRNA was significantly overexpressed in invasive and metastatic bladder cancer compared to noninvasive disease. Immunostaining of a bladder tumor tissue array designed to evaluate disease progression revealed increased ADAM15 immunoreactivity associated with increasing cancer stage and exhibited significantly stronger staining in metastatic samples. About half of the invasive tumors and the majority of the metastatic cases exhibited high ADAM15 staining index, while all low grade and noninvasive cases exhibited negative or low staining. The knockdown of ADAM15 mRNA expression significantly inhibited bladder tumor cell migration and reduced the invasive capacity of bladder tumor cells through MatrigelTM and monolayers of vascular endothelium. The knockdown of ADAM15 in a human xenograft model of bladder cancer inhibited tumor growth by 45% compared to controls. Structural modeling of the catalytic domain led to the design of a novel ADAM15-specific sulfonamide inhibitor that demonstrated bioactivity and significantly reduced the viability of bladder cancer cells in vitro and in human bladder cancer xenografts. Taken together, the results revealed an undescribed role of ADAM15 in the invasion of human bladder cancer and suggested that the ADAM15 catalytic domain may represent a viable

  13. Pioneers in CNS inhibition: 1. Ivan M. Sechenov, the first to clearly demonstrate inhibition arising in the brain.

    Science.gov (United States)

    Stuart, Douglas G; Schaefer, Andreas T; Massion, Jean; Graham, Brett A; Callister, Robert J

    2014-02-22

    This article reviews the contributions of Ivan Michailovich Sechenov [1829-1905] to the neurophysiological concept of central inhibition. He first studied this concept in the frog and on himself. Later his trainees extended the study of central inhibition to other mammalian species. Outside his own country, Sechenov is better known for his prescient contributions to physiological psychology. In Russia, however, he is also revered as "the father of Russian physiology," because of his contributions to neurophysiology and other aspects of physiology including blood gases and respiration, the physiology and biomechanics of movement, and general physiology concepts that appeared in his textbooks and later works he helped translate from largely German sources. After graduation from Moscow University Medical School in 1856 he spent 3½ years in Germany and Austria where he attended lectures and conducted research under the direction of several prominent physiologists and biochemists. In his subsequent academic career he held positions at universities in St. Petersburg (1860-1870; 1876-1888), Odessa (1871-1876) and Moscow (1890-1905). From 1860 onwards he was acclaimed as a physiologist in academic circles. He was also well known in Russian society for his public lectures on physiology and his views on physiological psychology. The latter resulted in him being branded "politically unreliable" by the tsarist bureaucracy from 1863 onwards. Sechenov's first (1862) study on central inhibition remains his most memorable. He delayed the withdrawal of a frog's foot from a weak acid solution by chemical or electrical stimulation of selected parts of the central nervous system. He also noted similar effects on his own hand during co-activation of other sensory inputs by tickling or teeth gnashing.

  14. Rediscovering community--reflections after Hurricane Sandy.

    Science.gov (United States)

    See, Sharon

    2013-01-01

    Hoboken, New Jersey, is a town of 50,000 residents located across the Hudson River from New York City. Most of Hoboken's infrastructure was compromised during Hurricane Sandy as a result of flooding and power outages that rendered many businesses inoperable, including all of the pharmacies in town. Despite a focus on emergency preparedness since Hurricane Katrina and 9/11, there were no contingencies in place to facilitate and assess the medication needs of the community in the event of a natural disaster. This essay describes how the author rediscovered the meaning of community, and through working with colleagues in other health care disciplines and non-health care volunteers, provided care to patients in suboptimal circumstances.

  15. Hurricane damaged fixed platforms and wellhead structures

    Energy Technology Data Exchange (ETDEWEB)

    Shuttleworth, E.P.; Frieze, P.A.

    1998-03-01

    The objective of this study was to review data on damages to offshore platforms with a view to determining their suitability for further exploitation and analysis through a preliminary assessment of trends in the data when viewed from a risk standpoint. To realise this objective, a database on hurricane and other storm related damages was generated and past design practice, particularly concerning environmental load levels, was established. Information was gathered on extreme wave heights, damages, platform details, pushover analyses and structural frame load tests. The information was obtained through: a literature survey of journals, conference proceedings, design codes and guidelines; approaches to organisations in the offshore industry with significant experience of hurricanes, storm-damaged structures and pushover analyses; and interrogation of three major databases on offshore storm and other damages - PMB, MMS and WOAD. (author)

  16. Lagrangian mixing in an axisymmetric hurricane model

    Directory of Open Access Journals (Sweden)

    B. Rutherford

    2009-09-01

    Full Text Available This paper discusses the extension of established Lagrangian mixing measures to make them applicable to data extracted from a 2-D axisymmetric hurricane simulation. Because of the non-steady and unbounded characteristics of the simulation, the previous measures are extended to a moving frame approach to create time-dependent mixing rates that are dependent upon the initial time of particle integration, and are computed for nonlocal regions. The global measures of mixing derived from finite-time Lyapunov exponents, relative dispersion, and a measured mixing rate are applied to distinct regions representing different characteristic feautures within the model. It is shown that these time-dependent mixing rates exhibit correlations with maximal tangential winds during a quasi-steady state, establishing a connection between mixing and hurricane intensity.

  17. Atlantic hurricane surge response to geoengineering

    Energy Technology Data Exchange (ETDEWEB)

    Moore, John C.; Grinsted, Aslak; Guo, Xiaoran; Yu, Xiaoyong; Jevrejeva, Svetlana; Rinke, Annette; Cui, Xuefeng; Kravitz, Ben; Lenton, Andrew; Watanabe, Shingo; Ji, Duoying

    2015-10-26

    Devastating Atlantic hurricanes are relatively rare events. However their intensity and frequency in a warming world may rapidly increase by a factor of 2-7 for each degree of increase in mean global temperature. Geoengineering by stratospheric sulphate aerosol injection cools the tropics relative to the polar regions, including the hurricane main development region in the Atlantic, suggesting that geoengineering may be an effective method of controlling hurricanes. We examine this hypothesis using 8 Earth System Model simulations of climate under the GeoMIP G3 and G4 schemes that use stratospheric aerosols to reduce the radiative forcing under the RCP4.5 scenario. Global mean temperature increases are greatly ameliorated by geoengineering, and tropical temperature increases are at most half of those in RCP4.5, but sulphate injection would have to double between 2020 and 2070 to balance RCP 4.5 to nearly 10 Tg SO2 yr-1, with consequent implications for damage to stratospheric ozone. We project changes in storm frequencies using a temperature-dependent Generalized Extreme Value statistical model calibrated by historical storm surges from 1923 and observed temperatures. The numbers of storm surge events as big as the one that caused the 2005 Katrina hurricane are reduced by about 50% compared with no geoengineering, but this is only marginally statistically significant. However, when sea level rise differences at 2070 between RCP4.5 and geoengineering are factored in to coastal flood risk, we find that expected flood levels are reduced by about 40 cm for 5 year events and perhaps halved for 50 year surges.

  18. Atlantic hurricane surge response to geoengineering.

    Science.gov (United States)

    Moore, John C; Grinsted, Aslak; Guo, Xiaoran; Yu, Xiaoyong; Jevrejeva, Svetlana; Rinke, Annette; Cui, Xuefeng; Kravitz, Ben; Lenton, Andrew; Watanabe, Shingo; Ji, Duoying

    2015-11-10

    Devastating floods due to Atlantic hurricanes are relatively rare events. However, the frequency of the most intense storms is likely to increase with rises in sea surface temperatures. Geoengineering by stratospheric sulfate aerosol injection cools the tropics relative to the polar regions, including the hurricane Main Development Region in the Atlantic, suggesting that geoengineering may mitigate hurricanes. We examine this hypothesis using eight earth system model simulations of climate under the Geoengineering Model Intercomparison Project (GeoMIP) G3 and G4 schemes that use stratospheric aerosols to reduce the radiative forcing under the Representative Concentration Pathway (RCP) 4.5 scenario. Global mean temperature increases are greatly ameliorated by geoengineering, and tropical temperature increases are at most half of those temperature increases in the RCP4.5. However, sulfate injection would have to double (to nearly 10 teragrams of SO2 per year) between 2020 and 2070 to balance the RCP4.5, approximately the equivalent of a 1991 Pinatubo eruption every 2 y, with consequent implications for stratospheric ozone. We project changes in storm frequencies using a temperature-dependent generalized extreme value statistical model calibrated by historical storm surges and observed temperatures since 1923. The number of storm surge events as big as the one caused by the 2005 Katrina hurricane are reduced by about 50% compared with no geoengineering, but this reduction is only marginally statistically significant. Nevertheless, when sea level rise differences in 2070 between the RCP4.5 and geoengineering are factored into coastal flood risk, we find that expected flood levels are reduced by about 40 cm for 5-y events and about halved for 50-y surges.

  19. Complicated grief associated with hurricane Katrina.

    Science.gov (United States)

    Shear, M Katherine; McLaughlin, Katie A; Ghesquiere, Angela; Gruber, Michael J; Sampson, Nancy A; Kessler, Ronald C

    2011-08-01

    Although losses are important consequences of disasters, few epidemiological studies of disasters have assessed complicated grief (CG) and none assessed CG associated with losses other than death of loved one. Data come from the baseline survey of the Hurricane Katrina Community Advisory Group, a representative sample of 3,088 residents of the areas directly affected by Hurricane Katrina. A brief screen for CG was included containing four items consistent with the proposed DSM-V criteria for a diagnosis of bereavement-related adjustment disorder. Fifty-eight and half percent of respondents reported a significant hurricane-related loss: Most-severe losses were 29.0% tangible, 9.5% interpersonal, 8.1% intangible, 4.2% work/financial, and 3.7% death of loved one. Twenty-six point one percent respondents with significant loss had possible CG and 7.0% moderate-to-severe CG. Death of loved one was associated with the highest conditional probability of moderate-to-severe CG (18.5%, compared to 1.1-10.5% conditional probabilities for other losses), but accounted for only 16.5% of moderate-to-severe CG due to its comparatively low prevalence. Most moderate-to-severe CG was due to tangible (52.9%) or interpersonal (24.0%) losses. Significant predictors of CG were mostly unique to either bereavement (racial-ethnic minority status, social support) or other losses (prehurricane history of psychopathology, social competence.). Nonbereavement losses accounted for the vast majority of hurricane-related possible CG despite risk of CG being much higher in response to bereavement than to other losses. This result argues for expansion of research on CG beyond bereavement and alerts clinicians to the need to address postdisaster grief associated with a wide range of losses. © 2011 Wiley-Liss, Inc.

  20. Hurricane Katrina as a "teachable moment"

    Science.gov (United States)

    Glantz, M. H.

    2008-04-01

    By American standards, New Orleans is a very old, very popular city in the southern part of the United States. It is located in Louisiana at the mouth of the Mississippi River, a river which drains about 40% of the Continental United States, making New Orleans a major port city. It is also located in an area of major oil reserves onshore, as well as offshore, in the Gulf of Mexico. Most people know New Orleans as a tourist hotspot; especially well-known is the Mardi Gras season at the beginning of Lent. People refer to the city as the "Big Easy". A recent biography of the city refers to it as the place where the emergence of modern tourism began. A multicultural city with a heavy French influence, it was part of the Louisiana Purchase from France in early 1803, when the United States bought it, doubling the size of the United States at that time. Today, in the year 2007, New Orleans is now known for the devastating impacts it withstood during the onslaught of Hurricane Katrina in late August 2005. Eighty percent of the city was submerged under flood waters. Almost two years have passed, and many individuals and government agencies are still coping with the hurricane's consequences. And insurance companies have been withdrawing their coverage for the region. The 2005 hurricane season set a record, in the sense that there were 28 named storms that calendar year. For the first time in hurricane forecast history, hurricane forecasters had to resort to the use of Greek letters to name tropical storms in the Atlantic and Gulf (Fig.~1). Hurricane Katrina was a Category 5 hurricane when it was in the middle of the Gulf of Mexico, after having passed across southern Florida. At landfall, Katrina's winds decreased in speed and it was relabeled as a Category 4. It devolved into a Category 3 hurricane as it passed inland when it did most of its damage. Large expanses of the city were inundated, many parts under water on the order of 20 feet or so. The Ninth Ward, heavily

  1. Coastal Change During Hurricane Isabel 2003

    Science.gov (United States)

    Morgan, Karen

    2009-01-01

    On September 18, 2003, Hurricane Isabel made landfall on the northern Outer Banks of North Carolina. At the U.S. Army Corps of Engineer's Field Research Facility in Duck, 125 km north of where the eyewall cut across Hatteras Island, the Category 2 storm generated record conditions for the 27 years of monitoring. The storm produced an 8.1 m high wave measured at a waverider buoy in 20 m of water and a 1.5 m storm surge. As part of a program to document and better understand the changes in vulnerability of the Nation's coasts to extreme storms, the U.S. Geological Survey (USGS), in collaboration with the National Aeronautics and Space Administration (NASA), surveyed the impact zone of Hurricane Isabel. Methods included pre- and post-storm photography, videography, and lidar. Hurricane Isabel caused extensive erosion and overwash along the Outer Banks near Cape Hatteras, including the destruction of houses, the erosion of protective sand dunes, and the creation of island breaches. The storm eroded beaches and dunes in Frisco and Hatteras Village, southwest of the Cape. Overwash deposits covered roads and filled homes with sand. The most extensive beach changes were associated with the opening of a new breach about 500 m wide that divided into three separate channels that completely severed the island southwest of Cape Hatteras. The main breach, and a smaller one several kilometers to the south (not shown), occurred at minima in both island elevation and island width.

  2. Hurricane Katrina as a "teachable moment"

    Directory of Open Access Journals (Sweden)

    M. H. Glantz

    2008-04-01

    Full Text Available By American standards, New Orleans is a very old, very popular city in the southern part of the United States. It is located in Louisiana at the mouth of the Mississippi River, a river which drains about 40% of the Continental United States, making New Orleans a major port city. It is also located in an area of major oil reserves onshore, as well as offshore, in the Gulf of Mexico. Most people know New Orleans as a tourist hotspot; especially well-known is the Mardi Gras season at the beginning of Lent. People refer to the city as the "Big Easy". A recent biography of the city refers to it as the place where the emergence of modern tourism began. A multicultural city with a heavy French influence, it was part of the Louisiana Purchase from France in early 1803, when the United States bought it, doubling the size of the United States at that time.

    Today, in the year 2007, New Orleans is now known for the devastating impacts it withstood during the onslaught of Hurricane Katrina in late August 2005. Eighty percent of the city was submerged under flood waters. Almost two years have passed, and many individuals and government agencies are still coping with the hurricane's consequences. And insurance companies have been withdrawing their coverage for the region.

    The 2005 hurricane season set a record, in the sense that there were 28 named storms that calendar year. For the first time in hurricane forecast history, hurricane forecasters had to resort to the use of Greek letters to name tropical storms in the Atlantic and Gulf (Fig.~1.

    Hurricane Katrina was a Category 5 hurricane when it was in the middle of the Gulf of Mexico, after having passed across southern Florida. At landfall, Katrina's winds decreased in speed and it was relabeled as a Category 4. It devolved into a Category 3 hurricane as it passed inland when it did most of its damage. Large expanses of the city were inundated, many parts under water on

  3. Expression of ADAMs ("a disintegrin and metalloprotease") in the human lung

    NARCIS (Netherlands)

    Dijkstra, Antoon; Postma, Dirkje S.; Noordhoek, Jacobien A.; Lodewijk, Monique E.; Kauffman, Henk F.; ten Hacken, Nick H. T.; Timens, Wim

    2009-01-01

    In view of the associations of "a disintegrin and metalloprotease" (ADAM) with respiratory diseases, we assessed the expression of various ADAMs in human lung tissue. Lung tissue was obtained from nine individuals who underwent surgery for lung cancer or underwent lung transplantation for emphysema.

  4. At læse Adam Smith er både befriende og irriterende

    DEFF Research Database (Denmark)

    Larsen, Steen Nepper

    2014-01-01

    Anmeldelse af Adam Smith: "Teorien om de moralske følelser", oversat af Claus Bratt Østergaard, udg. på Informations Forlag......Anmeldelse af Adam Smith: "Teorien om de moralske følelser", oversat af Claus Bratt Østergaard, udg. på Informations Forlag...

  5. Microautoradiography of [{sup 123}I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Ye, X.-X.; Chen, J.-C.; Liu, R.-S.; Wey, S.-P.; Lee, J.-S.; Chen, C.-C.; Fu, Y.-K.; Ting, Gann; Hwang, J.-J. E-mail: jjhwang@ym.edu.tw

    2004-07-01

    A radiopharmaceutical, {sup 123}I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine ([{sup 123}I]ADAM), has been developed recently for evaluation of how serotonin transporters (SERT) function in the brain. However, the detailed biodistribution and specific binding in certain brain areas are not well investigated. In this study, both phosphor plate imaging and microautoradiography were applied to explore the binding characteristics of [{sup 123}I]ADAM in SERT neurons. The effect of two psychotropics and one narcotic on the binding of [{sup 123}I]ADAM to SERT was also studied. Fluoxetine and desipramine, both are psychotropics and specific SERT ligands and decreased the affinity of [{sup 123}I]ADAM, while p-chloroamphetamine (PCA), a narcotic, destroyed most of serotonergic neurons, as well as reducing the concentration of serotonin and the number of SERT in the brain as shown by the biodistribution of [{sup 123}I]ADAM. Significant and selective accumulation of [{sup 123}I]ADAM in the areas from midbrain to brain stem in normal mice with maximum target-to-background ratio was found at 90 minutes postinjection. A rapid clearance of [{sup 131}I]ADAM at 120 minutes postinjection was found in the CA1, CA3 and ThN brain areas. In addition, the inhibition effect on binding ability of [{sup 123}I]ADAM to SERT by the psychotropics and the narcotic was found to have the order of: PCA > fluoxetine > desipramine.

  6. ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice

    DEFF Research Database (Denmark)

    Kronqvist, Pauliina; Kawaguchi, Nobuko; Albrechtsen, Reidar;

    2002-01-01

    we examined the role of the transmembrane ADAM12, a disintegrin and metalloprotease, which is normally associated with development and regeneration of skeletal muscle. We demonstrate that ADAM12 overexpression in the dystrophin-deficient mdx mice alleviated the muscle pathology in these animals...

  7. Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion

    DEFF Research Database (Denmark)

    Iba, K; Albrechtsen, R; Gilpin, B J;

    1999-01-01

    The ADAMs (A disintegrin and metalloprotease) comprise a family of membrane-anchored cell surface proteins with a putative role in cell-cell and/or cell-matrix interactions. By immunostaining, ADAM 12 (meltrin alpha) was up-regulated in several human carcinomas and could be detected along the tum...

  8. ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

    Directory of Open Access Journals (Sweden)

    Florent Letronne

    2016-07-01

    Full Text Available Although several ADAMs (A disintegrin-like and metalloproteases have been shown to contribute to the amyloid precursor protein (APP metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established. Transcriptomic analyses centred on metalloprotease genes unraveled a 50% decrease in ADAM30 expression that inversely correlates with amyloid load in Alzheimer's disease brains. Accordingly, in vitro down- or up-regulation of ADAM30 expression triggered an increase/decrease in Aβ peptides levels whereas expression of a biologically inactive ADAM30 (ADAM30mut did not affect Aβ secretion. Proteomics/cell-based experiments showed that ADAM30-dependent regulation of APP metabolism required both cathepsin D (CTSD activation and APP sorting to lysosomes. Accordingly, in Alzheimer-like transgenic mice, neuronal ADAM30 over-expression lowered Aβ42 secretion in neuron primary cultures, soluble Aβ42 and amyloid plaque load levels in the brain and concomitantly enhanced CTSD activity and finally rescued long term potentiation alterations. Our data thus indicate that lowering ADAM30 expression may favor Aβ production, thereby contributing to Alzheimer's disease development.

  9. A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo

    DEFF Research Database (Denmark)

    Gilpin, B J; Loechel, F; Mattei, M G

    1998-01-01

    , membrane-bound form designated ADAM 12-L (L for long form). These two forms arise by alternative splicing of a single gene located on chromosome 10q26. Northern blotting demonstrated that mRNAs of both forms are abundant in human term placenta and are also present in some tumor cell lines. The ADAM 12-L...

  10. ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy

    DEFF Research Database (Denmark)

    Guo, Ling T; Shelton, G Diane; Wewer, Ulla M

    2005-01-01

    We have recently shown that overexpression of ADAM12 results in increased muscle regeneration and significantly reduced pathology in mdx, dystrophin deficient mice. In the present study, we tested the effect of overexpressing ADAM12 in dy(W) laminin-deficient mice. dy mice have a very severe clin...

  11. Evaluation of the Serotonin Transporter Ligand 123I-ADAM for SPECT Studies on Humans

    DEFF Research Database (Denmark)

    Frokjaer, V.G.; Pinborg, Lars Hageman; Madsen, J.;

    2008-01-01

    transporters using (123)I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) in humans: an arterial plasma input model, simplified and Logan reference tissue models, and standardized uptake value ratios. METHODS: Nine subjects were scanned with dynamic (123)I-ADAM SPECT (mean age, 31 y...

  12. ADAM in Holland? : Plan van aanpak voor de pilot monitoring drugsgebruik onder arrestanten bij politie Haaglanden

    NARCIS (Netherlands)

    Broek, H. van den; Klerks, P.; Otter, P. den

    1999-01-01

    In de VS worden sinds 1987 systematisch gegevens verzameld over drugsgebruik onder aangehouden verdachten in het kader van het ADAM-programma. Als eerste stap naar een Nederlandse ADAM is vastgesteld in hoeverre er draagvlak bestaat voor een pilot in de politieregio Haaglanden. Eind 1998 heeft op he

  13. The futility of utility: how market dynamics marginalize Adam Smith

    Science.gov (United States)

    McCauley, Joseph L.

    2000-10-01

    Economic theorizing is based on the postulated, nonempiric notion of utility. Economists assume that prices, dynamics, and market equilibria are supposed to be derived from utility. The results are supposed to represent mathematically the stabilizing action of Adam Smith's invisible hand. In deterministic excess demand dynamics I show the following. A utility function generally does not exist mathematically due to nonintegrable dynamics when production/investment are accounted for, resolving Mirowski's thesis. Price as a function of demand does not exist mathematically either. All equilibria are unstable. I then explain how deterministic chaos can be distinguished from random noise at short times. In the generalization to liquid markets and finance theory described by stochastic excess demand dynamics, I also show the following. Market price distributions cannot be rescaled to describe price movements as ‘equilibrium’ fluctuations about a systematic drift in price. Utility maximization does not describe equilibrium. Maximization of the Gibbs entropy of the observed price distribution of an asset would describe equilibrium, if equilibrium could be achieved, but equilibrium does not describe real, liquid markets (stocks, bonds, foreign exchange). There are three inconsistent definitions of equilibrium used in economics and finance, only one of which is correct. Prices in unregulated free markets are unstable against both noise and rising or falling expectations: Adam Smith's stabilizing invisible hand does not exist, either in mathematical models of liquid market data, or in real market data.

  14. Regulation of human ADAM 12 protease by the prodomain. Evidence for a functional cysteine switch

    DEFF Research Database (Denmark)

    Loechel, F; Overgaard, M T; Oxvig, C

    1999-01-01

    , with the prodomain maintaining the protease in a latent form. We now provide evidence that the latency mechanism of ADAM 12 can be explained by the cysteine switch model, in which coordination of Zn2+ in the active site of the catalytic domain by a cysteine residue in the prodomain is critical for inhibition...... of the protease. Replacing Cys179 with other amino acids results in an ADAM 12 proform that is proteolytically active, but latency can be restored by placing cysteine at other positions in the propeptide. None of the amino acids adjacent to the crucial cysteine residue is essential for blocking activity...... of the protease domain. In addition to its latency function, the prodomain is required for exit of ADAM 12 protease from the endoplasmic reticulum. Tissue inhibitor of metalloprotease-1, -2, and -3 were not found to block proteolytic activity of ADAM 12, hence a physiological inhibitor of ADAM 12 protease...

  15. ADAM 12, a disintegrin metalloprotease, interacts with insulin-like growth factor-binding protein-3

    DEFF Research Database (Denmark)

    Shi, Z; Xu, Wei; Loechel, F

    2000-01-01

    , as yet the pregnancy-specific protease, or proteases, have not been identified. We utilized a yeast two-hybrid assay and a human placental cDNA library to investigate IGFBP-3-interacting proteins. A disintegrin and metalloprotease-12 (ADAM 12), a member of a family of metalloprotease disintegrins...... that is highly expressed in placental tissue, was identified as interacting with IGFBP-3. This interaction involved the cysteine-rich domain of ADAM 12. Unlike other members of this family of disintegrin metalloproteases that are membrane proteins, ADAM 12 exists as an alternatively spliced soluble secreted...... medium on a heparin-Sepharose column also proteolyzed IGFBP-3. The degradation pattern was similar to that seen with pregnancy serum, and the presence of ADAM 12-S in serum during pregnancy was confirmed. The data suggest that ADAM 12-S has IGFBP-3 protease activity, and it may contribute to the IGFBP-3...

  16. A role for ADAM12 in breast tumor progression and stromal cell apoptosis

    DEFF Research Database (Denmark)

    Kveiborg, Marie; Frohlich, Camilla; Albrechtsen, Reidar;

    2005-01-01

    of stromal fibroblasts in tumor initiation and progression has been elucidated. Here, we show that stromal cell apoptosis occurs in human breast carcinoma but is only rarely seen in nonmalignant breast lesions. Furthermore, we show that ADAM12, a disintegrin and metalloprotease up-regulated in human breast...... cancer, accelerates tumor progression in a mouse breast cancer model. ADAM12 does not influence tumor cell proliferation but rather confers both decreased tumor cell apoptosis and increased stromal cell apoptosis. This dual role of ADAM12 in governing cell survival is underscored by the finding that ADAM......12 increases the apoptotic sensitivity of nonneoplastic cells in vitro while rendering tumor cells more resistant to apoptosis. Together, these results show that the ability of ADAM12 to influence apoptosis may contribute to tumor progression....

  17. Unite simulation and analysis for vehicle suspension based on ADAMS/Matlab%ADAMS/Matlab 环境下车辆悬架联合仿真分析

    Institute of Scientific and Technical Information of China (English)

    梁栋; 邓兆祥; 郝军; 王恒元

    2012-01-01

    Based on the one-fourth automotive dynamics model in ADAMS/View,the optimal co-simulation system is established in the environment of Matlab/Simulink through the data connection between ADAMS and Matlab, then, the comparison is represented in term of co-simulation and single simulation in Matlab. It shows both of these two approaches make acceleration value of suspension mass-loaded and consumptive energy reduce, however, the approach of co-simulation has more pronounced effect.%针对ADAMS/View环境下某车辆1/4整车动力学模型,通过ADAMS/Control模块建立了ADAMS与Matlab软件之间的通信连接,在Matlab/Simulink环境下建立最优联合控制系统,运用ADAMS和Matlab/Simulink软件(即ADAMS/Matlab)进行联合仿真,并与在Matlab单一环境下运行的仿真模型进行对比分析.结果发现:两种分析方法都能使车辆悬架簧上总质量质心加速度均方根值和控制能量降低,而ADAMS/Matlab软件联合仿真控制下的悬架簧上总质量质心加速度和控制能量下降幅度更大.

  18. TLR4-mediated galectin-1 production triggers epithelial-mesenchymal transition in colon cancer cells through ADAM10- and ADAM17-associated lactate production.

    Science.gov (United States)

    Park, Ga Bin; Kim, Daejin

    2017-01-01

    Toll-like receptor 4 (TLR4) activation is a key contributor to the carcinogenesis of colon cancer. Overexpression of galectin-1 (Gal-1) also correlates with increased invasive activity of colorectal cancer. Lactate production is a critical predictive factor of risk of metastasis, but the functional relationship between intracellular lactate and Gal-1 expression in TLR4-activated colon cancer remains unknown. In this study, we investigated the underlying mechanism and role of Gal-1 in metastasis and invasion of colorectal cancer (CRC) cells after TLR4 stimulation. Exposure to the TLR4 ligand lipopolysaccharide (LPS) increased expression of Gal-1, induced EMT-related cytokines, triggered the activation of glycolysis-related enzymes, and promoted lactate production. Gene silencing of TLR4 and Gal-1 in CRC cells inhibited lactate-mediated epithelial-mesenchymal transition (EMT) after TLR4 stimulation. Gal-1-mediated activation of a disintegrin and metalloproteinase 10 (ADAM10) and ADAM 17 increased the invasion activity and expression of mesenchymal characteristics in LPS-activated CRC cells. Conversely, inhibition of ADAM10 or ADAM17 effectively blocked the generation of lactate and the migration capacity of LPS-treated CRC cells. Thus, the TLR4/Gal-1 signaling pathway regulates lactate-mediated EMT processes through the activation of ADAM10 and ADAM17 in CRC cells.

  19. Nova Scotia Power response to Hurricane Juan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-10-01

    Hurricane Juan hit the Halifax Regional Municipality on September 28, 2003, creating the largest outage in Nova Scotia Power's history. This detailed report documents the extensive damage that Hurricane Juan caused to the power transmission and distribution system in Nova Scotia. It also reviews the massive power restoration effort, with reference to numerous interviews, computer records and data logs which offer a wide range of observations, statistics and insights into the preparation and performance of Nova Scotia Power Inc. (NSPI) and the efforts of other key organizations following the storm. NSPI organized a recovery effort that matched the intensity of the hurricane. A fire in the Scotia Square Office Tower caused the evacuation of the company's call centre. The Tufts Cove station in Dartmouth, which generates 400 megawatts of power, was forced to shut down. Excess electricity was moved into New Brunswick and other jurisdictions to maintain system stability. The main priority was to restore customers back to service. Within 5 days of the hurricane, 95 per cent of those who lost power had service restored. Hurricane Juan caused the most damage to the transmission and distribution system in NSPI's history. Three out of five high capacity transmission lines were put out of service. Three 120-foot high transmission towers fell, and 17 main transmission lines were damaged and put out of service. Forty-five major substations were affected and 145 distribution feeders were damaged or tripped off, including 106 in the Halifax Regional Municipality. Large portions of 4,500 kilometres of local distribution lines in the Halifax Regional Municipality were damaged, including thousands of kilometers across the Northeast. The power crew, consisting of 2,000 individuals from the region and neighbouring utilities in New Brunswick and Maine, worked for 15 consecutive days to replace 275 transformers, 760 power poles, and 125,000 metres of conductor wire. NSPI

  20. ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects

    NARCIS (Netherlands)

    Manzine, Patricia Regina; Marcello, Elena; Borroni, Barbara; Kamphuis, Willem; Hol, Elly; Padovani, Alessandro; Nascimento, Carla Crispim; De Godoy Bueno, Patricia; Assis Carvalho Vale, Francisco; Iost Pavarini, Sofia Cristina; Di Luca, Monica; Cominetti, Márcia Regina

    2015-01-01

    ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No

  1. The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17

    DEFF Research Database (Denmark)

    Dombernowsky, Sarah Louise; Samsøe-Petersen, Jacob; Petersen, Camilla Hansson

    2015-01-01

    are poorly understood. Here, through a functional genome-wide siRNA screen, we identify the sorting protein PACS-2 as a regulator of ADAM17 trafficking and ErbB signalling. PACS-2 loss reduces ADAM17 cell-surface levels and ADAM17-dependent ErbB ligand shedding, without apparent effects on related proteases...

  2. Evaluation of Physically-based Model’s Predictive Skill for Hurricane-triggered Landslides: Case Study in North Carolina and Indonesia

    Science.gov (United States)

    Liao, Z.; Hong, Y.; Fukuoka, H.; Sassa, K.

    2009-12-01

    The key to advancing the predictability of rainfall-triggered landslides is to use physically-based, slope-stability models that simulate the dynamical response of the subsurface moisture to the spatiotemporal variability of rainfall in complex terrain. In the first study we quantitatively evaluate the spatiotemporal predictability of a Matlab version of TRIGRS (Transient Rainfall Infiltration and Grid-based Regional Slope-Stability Analysis) in the Blue Ridge Mountains of Macon County, North Carolina where Hurricane Ivan triggered widespread landslides in September, 2004. A high-resolution Digital Elevation Model (DEM) (6-meter LiDAR), USGS STATSGO soil database, and NOAA/NWS combined radar and gauge precipitation are used as inputs to the model. A local landslide inventory database from the North Carolina Department of Transportation is used to evaluate the model’s predictive skill for the landslide locations and timing over a 30-hour period of Hurricane Ivan’s passage. This study shows that TRIGRS demonstrates acceptable skill for landslide occurrences within a 120-meter radius. Real-time predictions with this model offer the potential to serve as a landslide warning system in areas where accurate rainfall forecasts and detailed field data are available. In the second study, a prototype early warning system has been developed to predict typhoon-induced shallow landslides over Java Island, Indonesia. The system utilizes a newly developed physically-based model that accounts for the contribution of rainfall infiltration and partial saturation to the shear strength of the soil in topographically complex catchments. geomorphological data are primarily based on a 30-meter ASTER DEM and 1-km soil maps, where precipitation forcing comes from satellite-based TRMM nowcasts and Weather Research Forecasting (WRF) forecasts. Model performance has been evaluated using a local landslide inventory, and it shows potential for predicting future typhoon-triggered landslides.

  3. THE BIBLICAL CHRONOTOPE IN THE “TRAVEL POEMS” BY IVAN A. BUNIN “THE BIRD’S SHADOW”

    Directory of Open Access Journals (Sweden)

    Tat’yana N. Kovalyova

    2015-11-01

    Full Text Available Ivan Bunin created his “Travel Poems” — “The Bird’s Shadow” — based on the impressions of his wanderings, between 1903 and 1909, across the Middle East countries including Turkey, Judaea, Palestine, Syria, Egypt, Algeria, Tunisia and Greece. Modern researchers present the East of Bunin’s “Travel Poems” as a certain generalized image of a “culturological aspect”which comprises the historical and cultures features of diff erent countries of the Levant. Meanwhile, Bunin emphasized that he took his journeys to Judaea and Palestine as a pilgrimage to the Holy Land, not as mere leisure travels. The importance of the Bible East in the “Travel Poems” is also determined by the fact that the largest part of his routes and most of his essays (7 essays of 11 are related to the Holy Land. Th is article examines the artistic space-time of the Palestinian Essays by Bunin and reveals and characterizes the biblical chronotope and the role of the key topos of the Old Testament and the New Testament. However, the author emphasizes a special meaning of some biblical topos. These are the places associated with the key biblical events and with intentionality of author’s consciousness, which generate a broad range of the keynotes of the cycle of stories: the Valley of Josaphat as the place of the upcoming Last Judgement; the Dead Sea as the symbol of visitation of God for the people’s sins; the Judean Desert where Jesus was tempted by devil; Jerusalem, Bethlehem, Nazareth, Gennisaret as the cities of ancient Palestine related to the events of the Terrestrial Life of Jesus Christ. The hero’s perception of the holy places, domination of the biblical space-time in the “Travel Poems” devoted to the pilgrimage to the Holy Land, aspiration for being projected to the biblical times, unity of the hero’s chronotope with the biblical chronotope — all this indicates the extreme importance of the biblical events for the author

  4. L’impossible intégration d’Ivan Šmelёv en France

    Directory of Open Access Journals (Sweden)

    Svetlana Maire

    2012-06-01

    Full Text Available Célèbre écrivain russe du début du XXe siècle, Ivan Šmelёv (1873-1950 doit, après les événements d’Octobre 1917, quitter la Russie avec sa femme. Le couple s’installe à Berlin en 1922 puis en France en 1923. Cette émigration forcée marque une nouvelle période dans la vie et dans l’œuvre de l’écrivain. Les biographies consacrées à Šmelёv s’accordent toutes sur un point : sa vie en exil fut extrêmement difficile et dès son arrivée, l’écrivain fut amer vis-à-vis de son pays d’accueil et de ses habitants. En effet, bien qu’il ait vécu un quart de siècle sur sa terre d’accueil, l’écrivain ne s’y intégra jamais vraiment, faisant le choix de rester en marge de la société française. Il reste à comprendre pourquoi Šmelёv n’a jamais pu s’y intégrer. Dans le présent article, je me propose de tenter de répondre à cette question en me basant sur les textes de l’écrivain. Pour ce faire, je retrace tout d’abord, étape par étape, les raisons qui l’ont poussé à s’installer en France. Ensuite, je me focalise sur l’évolution de ses ressentiments durant son exil. Enfin, dans la dernière partie, je mets en évidence quelques éléments de corrélation entre sa non-intégration dans la société d’accueil et son repli sur lui-même.

  5. Avifauna response to hurricanes: regional changes in community similarity

    Science.gov (United States)

    Chadwick D. Rittenhouse; Anna M. Pidgeon; Thomas P. Albright; Patrick D. Culbert; Murray K. Clayton; Curtis H. Flather; Chengquan Huang; Jeffrey G. Masek; Volker C. Radeloff

    2010-01-01

    Global climate models predict increases in the frequency and intensity of extreme climatic events such as hurricanes, which may abruptly alter ecological processes in forests and thus affect avian diversity. Developing appropriate conservation measures necessitates identifying patterns of avifauna response to hurricanes. We sought to answer two questions: (1) does...

  6. Long-term response of Caribbean palm forests to hurricanes

    Science.gov (United States)

    Ariel Lugo; J.L. Frangi

    2016-01-01

    We studied the response of Prestoea montana (Sierra Palm, hereafter Palm) brakes and a Palm floodplain forest to hurricanes in the Luquillo Experimental Forest in Puerto Rico. Over a span of 78 years, 3 hurricanes passed over the study sites for which we have 64 years of measurements for Palm brakes and 20 years for the Palm floodplain forest. For each stand, species...

  7. Resilience of Professional Counselors Following Hurricanes Katrina and Rita

    Science.gov (United States)

    Lambert, Simone F.; Lawson, Gerard

    2013-01-01

    Professional counselors who provided services to those affected by Hurricanes Katrina and Rita completed the K6+ (screen for severe mental illness), the Posttraumatic Growth Inventory, and the Professional Quality of Life Scale. Results indicated that participants who survived the hurricanes had higher levels of posttraumatic growth than…

  8. The Business of Intimacy: Hurricanes and Howling Wolves

    Science.gov (United States)

    Paley, Vivian

    2006-01-01

    The date is September 9, 2005. This article is set in a rural Wisconsin community, a thousand miles north of New Orleans, where Hurricane Katrina is about to make landfall. The four- and five- year- olds in Mrs. Olson's classroom have never experienced a hurricane or seen flood waters rise to cover the farms and houses they know, but they cannot…

  9. Resilience of Professional Counselors Following Hurricanes Katrina and Rita

    Science.gov (United States)

    Lambert, Simone F.; Lawson, Gerard

    2013-01-01

    Professional counselors who provided services to those affected by Hurricanes Katrina and Rita completed the K6+ (screen for severe mental illness), the Posttraumatic Growth Inventory, and the Professional Quality of Life Scale. Results indicated that participants who survived the hurricanes had higher levels of posttraumatic growth than…

  10. Teacher Guidelines for Helping Students after a Hurricane

    Science.gov (United States)

    National Child Traumatic Stress Network, 2013

    2013-01-01

    Being in a hurricane can be very frightening, and the days, weeks, and months following the storm can be very stressful. Most families recover over time, especially with the support of relatives, friends, and their community. But different families may have different experiences during and after a hurricane, and how long it takes them to recover…

  11. Post-hurricane forest damage assessment using satellite remote sensing

    Science.gov (United States)

    W. Wang; J.J. Qu; X. Hao; Y. Liu; J.A. Stanturf

    2010-01-01

    This study developed a rapid assessment algorithm for post-hurricane forest damage estimation using moderate resolution imaging spectroradiometer (MODIS) measurements. The performance of five commonly used vegetation indices as post-hurricane forest damage indicators was investigated through statistical analysis. The Normalized Difference Infrared Index (NDII) was...

  12. Mass Media Use by College Students during Hurricane Threat

    Science.gov (United States)

    Piotrowski, Chris

    2015-01-01

    There is a dearth of studies on how college students prepare for the threat of natural disasters. This study surveyed college students' preferences in mass media use prior to an approaching hurricane. The convenience sample (n = 76) were from a university located in the hurricane-prone area of the central Gulf of Mexico coast. Interestingly,…

  13. Experience of Hurricane Katrina and Reported Intimate Partner Violence

    Science.gov (United States)

    Harville, Emily W.; Taylor, Catherine A.; Tesfai, Helen; Xiong, Xu; Buekens, Pierre

    2011-01-01

    Intimate partner violence (IPV) has been associated with stress, but few studies have examined the effect of natural disaster on IPV. In this study, the authors examine the relationship between experience of Hurricane Katrina and reported relationship aggression and violence in a cohort of 123 postpartum women. Hurricane experience is measured…

  14. Retention of Displaced Students after Hurricanes Katrina and Rita

    Science.gov (United States)

    Coco, Joshua Christian

    2017-01-01

    The purpose of the study was to investigate the strategies that university leaders implemented to improve retention of displaced students in the aftermaths of Hurricanes Katrina and Rita. The universities that participated in this study admitted displaced students after Hurricanes Katrina and Rita. This study utilized a qualitative…

  15. Physical aspects of Hurricane Hugo in Puerto Rico

    Science.gov (United States)

    Scatena, F.N.; Larsen, Matthew C.

    1991-01-01

    On 18 September 1989 the western part ofHurricane Hugo crossed eastern Puerto Rico and the Luquillo Experimental Forest (LEF). Storm-facing slopes on the northeastern part of the island that were within 15 km of the eye and received greater than 200 mm of rain were most affected by the storm. In the LEF and nearby area, recurrence intervals associated with Hurricane Hugo were 50 yr for wind velocity, 10 to 31 yr for stream discharge, and 5 yr for rainfall intensity. To compare the magnitudes of the six hurricanes to pass over PuertoRico since 1899, 3 indices were developed using the standardized values of the product of: the maximum sustained wind speed at San Juan squared and storm duration; the square of the product of the maximum sustained wind velocity at San Juan and the ratio of the distance between the hurricane eye and San Juan to the distance between the eye and percentage of average annual rainfall delivered by the storm. Based on these indices, HurricaneHugo was of moderate intensity. However, because of the path of Hurricane Hugo, only one of these six storms (the 1932 storm) caused more damage to the LEF than Hurricane Hugo. Hurricanes of Hugo's magnitude are estimated to pass over the LEF once every 50-60 yr, on average. 

  16. Teacher Guidelines for Helping Students after a Hurricane

    Science.gov (United States)

    National Child Traumatic Stress Network, 2013

    2013-01-01

    Being in a hurricane can be very frightening, and the days, weeks, and months following the storm can be very stressful. Most families recover over time, especially with the support of relatives, friends, and their community. But different families may have different experiences during and after a hurricane, and how long it takes them to recover…

  17. Experience of Hurricane Katrina and Reported Intimate Partner Violence

    Science.gov (United States)

    Harville, Emily W.; Taylor, Catherine A.; Tesfai, Helen; Xiong, Xu; Buekens, Pierre

    2011-01-01

    Intimate partner violence (IPV) has been associated with stress, but few studies have examined the effect of natural disaster on IPV. In this study, the authors examine the relationship between experience of Hurricane Katrina and reported relationship aggression and violence in a cohort of 123 postpartum women. Hurricane experience is measured…

  18. Predicting hurricane wind damage by claim payout based on Hurricane Ike in Texas

    Directory of Open Access Journals (Sweden)

    Ji-Myong Kim

    2016-09-01

    Full Text Available The increasing occurrence of natural disasters and their related damage have led to a growing demand for models that predict financial loss. Although considerable research on the financial losses related to natural disasters has found significant predictors, there has been a lack of comprehensive study that addresses the relationship among vulnerabilities, natural disasters, and the economic losses of individual buildings. This study identifies the vulnerability indicators for hurricanes to establish a metric to predict the related financial loss. We classify hurricane-prone areas by highlighting the spatial distribution of losses and vulnerabilities. This study used a Geographical Information System (GIS to combine and produce spatial data and a multiple regression method to establish a wind damage prediction model. As the dependent variable, we used the value of the Texas Windstorm Insurance Association (TWIA claim payout divided by the appraised values of the buildings to predict real economic loss. As independent variables, we selected a hurricane indicator and built environment vulnerability indicators. The model we developed can be used by government agencies and insurance companies to predict hurricane wind damage.

  19. ESTABLISHMENT OF THE STATE OF SPINE DEFORMITY IN STUDENTS OF THE SECONDARY SCHOOL „IVAN-GORAN KOVAČIĆ“, HERCEG NOVI

    Directory of Open Access Journals (Sweden)

    Grujo Bjeković

    2006-06-01

    Full Text Available Subject of this research is establishment of a spine deformity existence in students of the secondary school „Ivan-Goran Kovačić“ based in Herceg Novi, and the school role in their removal. The aim of the research is to provide actual knowledge and results about grow, growth and body posture conditions of students at the secondary school „Ivan-Goran Kovačić“in Herceg Novi. The sample is represented by 115 students, assigned in four classes. The selected sample is made of four classes, out of which is one from each grade, i.e. first, second, third and fourth grade. Those classes represent the student population in the whole school. Variables in this research, at the selected sample of students, are follows: spine deformities, lordosis, kyphosis and scoliosis. Analysis of the results obtained after the research has been completed shows that the functional stage of scoliotic deformity is presented at the majority students from the sample. The number of students with kyphosis and lordosis deformity of spine is considerably lower. Research results show that scoliotic, kyphotic and lordotic body postures are in the range of functional changes. Scoliosis deformities of spine were, as per the results, more presented in the female students than in the male students

  20. Nuclear trafficking of the HIV-1 pre-integration complex depends on the ADAM10 intracellular domain

    Energy Technology Data Exchange (ETDEWEB)

    Endsley, Mark A., E-mail: maendsle@utmb.edu [Department Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 (United States); Somasunderam, Anoma D., E-mail: asomasun@utmb.edu [Department Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 (United States); Li, Guangyu, E-mail: LIG001@mail.etsu.edu [Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 (United States); Oezguen, Numan, E-mail: numan.oezguen@bcm.edu [Department of Pathology and Immunology, Microbiome Center, Texas Children' s Hospital, Houston, TX 77030 (United States); Thiviyanathan, Varatharasa, E-mail: Varatharasa.Thiviyanathan@uth.tmc.edu [Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030 (United States); Murray, James L., E-mail: jmurray100@yahoo.com [GeneTAG Technology, Inc., 3155 Northwoods Place, Norcross, GA 30071 (United States); Rubin, Donald H., E-mail: don.h.rubin@vanderbilt.edu [Research Medicine, VA Tennessee Valley Healthcare System, 1310 24th Ave. South, Nashville, TN 37212 (United States); Departments of Medicine, Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Ave South, Nashville, TN 37232 (United States); Hodge, Thomas W., E-mail: twhodge3@gmail.com [Pre-clinical and Antiviral Research, Tamir Biotechnology, Inc., 12625 High Bluff Dr., Suite 113, San Diego, CA 92130 (United States); and others

    2014-04-15

    Previously, we showed that ADAM10 is necessary for HIV-1 replication in primary human macrophages and immortalized cell lines. Silencing ADAM10 expression interrupted the HIV-1 life cycle prior to nuclear translocation of viral cDNA. Furthermore, our data indicated that HIV-1 replication depends on the expression of ADAM15 and γ-secretase, which proteolytically processes ADAM10. Silencing ADAM15 or γ-secretase expression inhibits HIV-1 replication between reverse transcription and nuclear entry. Here, we show that ADAM10 expression also supports replication in CD4{sup +} T lymphocytes. The intracellular domain (ICD) of ADAM10 associates with the HIV-1 pre-integration complex (PIC) in the cytoplasm and immunoprecipitates and co-localizes with HIV-1 integrase, a key component of PIC. Taken together, our data support a model whereby ADAM15/γ-secretase processing of ADAM10 releases the ICD, which then incorporates into HIV-1 PIC to facilitate nuclear trafficking. Thus, these studies suggest ADAM10 as a novel therapeutic target for inhibiting HIV-1 prior to nuclear entry. - Highlights: • Nuclear trafficking of the HIV-1 pre-integration complex depends on ADAM10. • ADAM10 associates with HIV-1 integrase in the pre-integration complex. • HIV-1 replication depends on the expression of ADAM15 and γ-secretase. • Silencing ADAM15 or γ-secretase expression inhibits nuclear import of viral cDNA. • ADAM10 is important for HIV-1 replication in human macrophages and CD4{sup +} T lymphocytes.

  1. Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.

    Science.gov (United States)

    Maretzky, Thorsten; Yang, Guangli; Ouerfelli, Ouathek; Overall, Christopher M; Worpenberg, Susanne; Hassiepen, Ulrich; Eder, Joerg; Blobel, Carl P

    2009-04-28

    ADAM15 (a disintegrin and metalloproteinase 15) is a membrane-anchored metalloproteinase, which is overexpressed in several human cancers and has been implicated in pathological neovascularization and prostate cancer metastasis. Yet, little is known about the catalytic properties of ADAM15. Here, we purified soluble recombinant ADAM15 to test for its ability to cleave a library of peptide substrates. However, we found no processing of any of the peptide substrates tested here, and therefore turned to cell-based assays to characterize the catalytic properties of ADAM15. Overexpression of full-length membrane-anchored ADAM15 or the catalytically inactive ADAM15E-->A together with various membrane proteins resulted in increased release of the extracellular domain of the fibroblast growth factor receptor 2iiib (FGFR2iiib) by ADAM15, but not ADAM15E-->A. This provided a robust assay for a characterization of the catalytic properties of ADAM15 in intact cells. We found that increased expression of ADAM15 resulted in increased FGFR2iiib shedding, but that ADAM15 was not stimulated by phorbol esters or calcium ionophores, two commonly used activators of ectodomain shedding. Moreover, ADAM15-dependent processing of FGFR2iiib was inhibited by the hydroxamate-based metalloproteinase inhibitors marimastat, TAPI-2 and GM6001, and by 50 nM TIMP-3 (tissue inhibitor of metalloproteinases 3), but not by 100 nM TIMP-1, and only weakly by 100 nM TIMP-2. These results define key catalytic properties of ADAM15 in cells and its response to stimulators and inhibitors of ectodomain shedding. A cell-based assay for the catalytic activity of ADAM15 could aid in identifying compounds, which could be used to block the function of ADAM15 in pathological neovascularization and cancer.

  2. On the Impact Angle of Hurricane Sandy's New Jersey Landfall

    Science.gov (United States)

    Hall, Timothy M.; Sobel, Adam H.

    2013-01-01

    Hurricane Sandy's track crossed the New Jersey coastline at an angle closer to perpendicular than any previous hurricane in the historic record, one of the factors contributing to recordsetting peak-water levels in parts of New Jersey and New York. To estimate the occurrence rate of Sandy-like tracks, we use a stochastic model built on historical hurricane data from the entire North Atlantic to generate a large sample of synthetic hurricanes. From this synthetic set we calculate that under long-term average climate conditions, a hurricane of Sandy's intensity or greater (category 1+) makes NJ landfall at an angle at least as close to perpendicular as Sandy's at an average annual rate of 0.0014 yr-1 (95% confidence range 0.0007 to 0.0023); i.e., a return period of 714 years (95% confidence range 435 to 1429).

  3. Hurricane Sandy: Shared Trauma and Therapist Self-Disclosure.

    Science.gov (United States)

    Rao, Nyapati; Mehra, Ashwin

    2015-01-01

    Hurricane Sandy was one of the most devastating storms to hit the United States in history. The impact of the hurricane included power outages, flooding in the New York City subway system and East River tunnels, disrupted communications, acute shortages of gasoline and food, and a death toll of 113 people. In addition, thousands of residences and businesses in New Jersey and New York were destroyed. This article chronicles the first author's personal and professional experiences as a survivor of the hurricane, more specifically in the dual roles of provider and trauma victim, involving informed self-disclosure with a patient who was also a victim of the hurricane. The general analytic framework of therapy is evaluated in the context of the shared trauma faced by patient and provider alike in the face of the hurricane, leading to important implications for future work on resilience and recovery for both the therapist and patient.

  4. Instrumentality in health care: a response to Adam Oliver.

    Science.gov (United States)

    Tanenbaum, Sandra J

    2015-07-01

    In his paper, 'Incentivizing improvements in health care delivery', Adam Oliver discusses recent efforts to manage the performance of health care workers in the United States and United Kingdom. Overall, the results of performance management seem to be mixed, but Oliver's discussion hints at a more fundamental question about this approach, specifically: what are the limits of a focused instrumentality in a context as rich, fluid and collaborative as the delivery of health care? Might performance management schemes actually frustrate the efforts of conscientious health care workers? Indicators make few allowances for the heterogeneity of treatment effects or patient values or preferences. Health care workers may also face pressure to appear to satisfy indicators that are actually impossible to satisfy.

  5. A Disintegrin and Metalloprotease (ADAM: Historical Overview of Their Functions

    Directory of Open Access Journals (Sweden)

    Nives Giebeler

    2016-04-01

    Full Text Available Since the discovery of the first disintegrin protein from snake venom and the following identification of a mammalian membrane-anchored metalloprotease-disintegrin implicated in fertilization, almost three decades of studies have identified additional members of these families and several biochemical mechanisms regulating their expression and activity in the cell. Most importantly, new in vivo functions have been recognized for these proteins including cell partitioning during development, modulation of inflammatory reactions, and development of cancers. In this review, we will overview the a disintegrin and metalloprotease (ADAM family of proteases highlighting some of the major research achievements in the analysis of ADAMs’ function that have underscored the importance of these proteins in physiological and pathological processes over the years.

  6. Adam Smith y la teoría social

    Directory of Open Access Journals (Sweden)

    Jorge López Lloret

    2014-11-01

    Full Text Available El presente artículo estudia las ideas sociales de Adam Smith en su contexto histórico.Como instrumentos de análisis recurre a las nociones de «micro-sociología» y «macro-sociología», así como al enfoque dramatúrgico de la sociología de Goffman. Smith desarrolló un pensamiento social «micro» en La teoría de los sentimientos morales y otro «macro» en La riqueza de las naciones. Identificó además al objeto (como producto de la manufactura y como bien de consumo como el elemento de enlace entre ambas dimensiones, en un doble sentido: 1 como parte de nuestra puesta en escena cotidiana, y 2 como mediador de las relaciones sociales en unos contextos urbanos cada vez más complicados.

  7. Adam Smith and the new era of China

    Directory of Open Access Journals (Sweden)

    Aníbal Carlos Zottele

    2013-01-01

    Full Text Available ural area has been the quiet main character of China’s economic development. The history of this thousand-year-old culture seems to be exempted from further comments about its role. Its importance has been strongly expressed during crisis which institutions of that great nation in XX century were shook. Agricultural sector was the key in modernization period initiated in 1980 even in the later phases. Agriculture preponderance as progress support of the nations is presented by Scottish thinker Adam Smith in his work An Inquiry into the Nature and Causes of the Wealth of Nations. The status of Chinese development in XVII y XVIII centuries has been characterized in this document as well as the natural order of progress against unnatural or retrograde order followed by the Netherlands, in that time the country that had achieved higher levels growth in Europe. Apparently, at present, China repeats its old experiences by concentrating on the path praised by Smith.

  8. William E. Adams: Thomas Mann and The Magic Mountain.

    Science.gov (United States)

    Naef, A P

    1998-01-01

    The lobectomy for carcinoma of the lung performed by William E. Adams in 1946 on Thomas Mann, author of the tuberculosis saga The Magic Mountain, deserves to be added to Harold Ellis's series of "historically famous operations." This lobectomy, by which the surgeon cured his far more famous patient, was only one episode in his 40 eventful years as Chicago's leading pioneer in early thoracic surgery. The historic case is well documented by preoperative, operative, and pathology reports obtained through the courtesy of still-living witnesses and associates, friends of the author. Thomas Mann died 9 years later of an aortoiliac rupture at the University Hospital in Zurich. At autopsy no local recurrence or distal metastasis was found.

  9. Defenses and morality: Adam Smith, Sigmund Freud, and contemporary psychoanalysis.

    Science.gov (United States)

    Gabrinetti, Paul A; Özler, Sule

    2014-10-01

    In this paper we follow the development and transmission of moral learning from Adam Smith's impartial spectator to Sigmund Freud's superego and then to contemporary psychoanalysis. We argue that defenses are an integral component in the acquisition of any moral system. Elaborating on this argument, we assert that there is a progression from defensive systems that are "closed" to defensive systems that are "open," as defined in a recent work by Novick and Novick. The former system is "static, avoids reality, and is characterized by power dynamics, sadomasochism, and omnipotent defense." The latter, on the other hand, is a system that allows for "joy, creativity, spontaneity, love and it is attuned to reality." Furthermore, while Smith and Freud's systems are more one-person systems of defense, contemporary psychoanalysis has moved to more of a two-person system.

  10. A Pull Back Theorem in the Adams Spectral Sequence

    Institute of Scientific and Technical Information of China (English)

    Jin Kun LIN

    2008-01-01

    This paper proves that, for any generator x∈Exts,tq (Zp,Zp), if (1L∧i)*φ*(x)∈Exts+1,tq+2qA (H*L∧M,Zp) is a perm anent cycle in the Adams spectral sequence (ASS), then h0x∈Exts+1,tq+q (Zp,Zp) also is a permenent cycle in the ASS. As an application, the paper obtains that h0x∈h0hnhm∈Ext3,p n q+p m q+q(Zp,Zp) is a permanent cycle in the ASS and it converges to elements of order p in the stable homotopy groups of spheres πpnq+pmq+q -3S ,where p≥5 is a prime, s≤4, n≥m +2 ≥4 and M is the Moore spectrum.

  11. Cable shovel simulation modeling in the ADAMS environment

    Energy Technology Data Exchange (ETDEWEB)

    Frimpong, S.; Hu, Y.; Chang, Z. [Alberta Univ., Edmonton, AB (Canada). Centre for Advanced Energy and Minerals Research

    2003-07-01

    This paper presents a computer simulation model for cable shovels used in surface mining operations. The shovels are subject to significant wear and tear as well as fatigue failure in equipment components resulting in downtime, reduced efficiency and high production costs. The ADAMS virtual prototyping software program simulates realistic full-motion behaviour of complex mechanical systems and offers quick analysis for multiple optimal design options. Virtual prototyping reduces the need for costly physical prototypes, improves design quality and reduces product development time. The paper presents examples where the method was applied in actual mining operations. In particular, the model was used simulate the performance of cable shovels during actual digging operations. It was used to determine energy consumption under a range of digging conditions and produced efficient digging profiles. The software is also capable of simulating the critical parameters that are necessary for evaluating and optimizing the performance and energy consumption of cable shovels. 8 refs., 2 tabs., 8 figs.

  12. Econophysical visualization of Adam Smith’s invisible hand

    Science.gov (United States)

    Cohen, Morrel H.; Eliazar, Iddo I.

    2013-02-01

    Consider a complex system whose macrostate is statistically observable, but yet whose operating mechanism is an unknown black-box. In this paper we address the problem of inferring, from the system’s macrostate statistics, the system’s intrinsic force yielding the observed statistics. The inference is established via two diametrically opposite approaches which result in the very same intrinsic force: a top-down approach based on the notion of entropy, and a bottom-up approach based on the notion of Langevin dynamics. The general results established are applied to the problem of visualizing the intrinsic socioeconomic force-Adam Smith’s invisible hand-shaping the distribution of wealth in human societies. Our analysis yields quantitative econophysical representations of figurative socioeconomic forces, quantitative definitions of “poor” and “rich”, and a quantitative characterization of the “poor-get-poorer” and the “rich-get-richer” phenomena.

  13. Asymmetric oceanic response to a hurricane: Deep water observations during Hurricane Isaac

    Science.gov (United States)

    Spencer, Laura J.; DiMarco, Steven F.; Wang, Zhankun; Kuehl, Joseph J.; Brooks, David A.

    2016-10-01

    The eye of Hurricane Isaac passed through the center of an array of six deep water water-column current meter moorings deployed in the northern Gulf of Mexico. The trajectory of the hurricane provided for a unique opportunity to quantify differences in the full water-column oceanic response to a hurricane to the left and right of the hurricane trajectory. Prior to the storm passage, relative vorticity on the right side of the hurricane was strongly negative, while on the left, relative vorticity was positive. This resulted in an asymmetry in the near-inertial frequencies oceanic response at depth and horizontally. A shift in the response to a slightly larger inertial frequencies ˜1.11f was observed and verified by theory. Additionally, the storm passage coincided with an asymmetric change in relative vorticity in the upper 1000 m, which persisted for ˜15 inertial periods. Vertical propagation of inertial energy was estimated at 29 m/d, while horizontal propagation at this frequency was approximately 5.7 km/d. Wavelet analysis showed two distinct subinertial responses, one with a period of 2-5 days and another with a period of 5-12 days. Analysis of the subinertial bands reveals that the spatial and temporal scales are shorter and less persistent than the near-inertial variance. As the array is geographically located near the site of the Deep Water Horizon oil spill, the spatial and temporal scales of response have significant implications for the fate, transport, and distribution of hydrocarbons following a deep water spill event.

  14. The ADAMs family of proteases as targets for the treatment of cancer.

    Science.gov (United States)

    Mullooly, Maeve; McGowan, Patricia M; Crown, John; Duffy, Michael J

    2016-08-01

    The ADAMs (a disintegrin and metalloproteases) are transmembrane multidomain proteins implicated in multiple biological processes including proteolysis, cell adhesion, cell fusion, cell proliferation and cell migration. Of these varied activities, the best studied is their role in proteolysis. However, of the 22 ADAMs believed to be functional in humans, only approximately a half possess matrix metalloproteinase (MMP)-like protease activity. In contrast to MMPs which are mostly implicated in the degradation of extracellular matrix proteins, the main ADAM substrates are the ectodomains of type I and type II transmembrane proteins. These include growth factor/cytokine precursors, growth factor/cytokine receptors and adhesion proteins. Recently, several different ADAMs, especially ADAM17, have been shown to play a role in the development and progression of multiple cancer types. Consistent with this role in cancer, targeting ADAM17 with either low molecular weight inhibitors or monoclonal antibodies was shown to have anti-cancer activity in multiple preclinical systems. Although early phase clinical trials have shown no serious side effects with a dual ADAM10/17 low molecular weight inhibitor, the consequences of long-term treatment with these agents is unknown. Furthermore, efficacy in clinical trials remains to be shown.

  15. Shelf sediment transport during hurricanes Katrina and Rita

    Science.gov (United States)

    Xu, Kehui; Mickey, Rangley C.; Chen, Qin; Harris, Courtney K.; Hetland, Robert D.; Hu, Kelin; Wang, Jiaze

    2016-05-01

    Hurricanes can greatly modify the sedimentary record, but our coastal scientific community has rather limited capability to predict hurricane-induced sediment deposition. A three-dimensional sediment transport model was developed in the Regional Ocean Modeling System (ROMS) to study seabed erosion and deposition on the Louisiana shelf in response to Hurricanes Katrina and Rita in the year 2005. Sensitivity tests were performed on both erosional and depositional processes for a wide range of erosional rates and settling velocities, and uncertainty analysis was done on critical shear stresses using the polynomial chaos approximation method. A total of 22 model runs were performed in sensitivity and uncertainty tests. Estimated maximum erosional depths were sensitive to the inputs, but horizontal erosional patterns seemed to be controlled mainly by hurricane tracks, wave-current combined shear stresses, seabed grain sizes, and shelf bathymetry. During the passage of two hurricanes, local resuspension and deposition dominated the sediment transport mechanisms. Hurricane Katrina followed a shelf-perpendicular track before making landfall and its energy dissipated rapidly within about 48 h along the eastern Louisiana coast. In contrast, Hurricane Rita followed a more shelf-oblique track and disturbed the seabed extensively during its 84-h passage from the Alabama-Mississippi border to the Louisiana-Texas border. Conditions to either side of Hurricane Rita's storm track differed substantially, with the region to the east having stronger winds, taller waves and thus deeper erosions. This study indicated that major hurricanes can disturb the shelf at centimeter to meter levels. Each of these two hurricanes suspended seabed sediment mass that far exceeded the annual sediment inputs from the Mississippi and Atchafalaya Rivers, but the net transport from shelves to estuaries is yet to be determined. Future studies should focus on the modeling of sediment exchange between

  16. Gulf of Mexico hurricane wave simulations using SWAN: Bulk formula-based drag coefficient sensitivity for Hurricane Ike

    NARCIS (Netherlands)

    Huang, Y.; Weisberg, R.H.; Zheng, L.; Zijlema, M.

    2013-01-01

    The effects of wind input parameterizations on wave estimations under hurricane conditions are examined using the unstructured grid, third-generation wave model, Simulating WAves Nearshore (SWAN). Experiments using Hurricane Ike wind forcing, which impacted the Gulf of Mexico in 2008, illustrate tha

  17. Hurricane impacts on a pair of coastal forested watersheds: implications of selective hurricane damage to forest structure and streamflow dynamics

    Science.gov (United States)

    A.D. Jayakaran; T.M. Williams; H. Ssegane; D.M. Amatya; B. Song; C.C. Trettin

    2014-01-01

    Hurricanes are infrequent but influential disruptors of ecosystem processes in the southeastern Atlantic and Gulf coasts. Every southeastern forested wetland has the potential to be struck by a tropical cyclone. We examined the impact of Hurricane Hugo on two paired coastal South Carolina watersheds in terms of streamflow and vegetation dynamics, both before and after...

  18. Gulf of Mexico hurricane wave simulations using SWAN: Bulk formula-based drag coefficient sensitivity for Hurricane Ike

    NARCIS (Netherlands)

    Huang, Y.; Weisberg, R.H.; Zheng, L.; Zijlema, M.

    2013-01-01

    The effects of wind input parameterizations on wave estimations under hurricane conditions are examined using the unstructured grid, third-generation wave model, Simulating WAves Nearshore (SWAN). Experiments using Hurricane Ike wind forcing, which impacted the Gulf of Mexico in 2008, illustrate tha

  19. Gulf of Mexico hurricane wave simulations using SWAN: Bulk formula-based drag coefficient sensitivity for Hurricane Ike

    NARCIS (Netherlands)

    Huang, Y.; Weisberg, R.H.; Zheng, L.; Zijlema, M.

    2013-01-01

    The effects of wind input parameterizations on wave estimations under hurricane conditions are examined using the unstructured grid, third-generation wave model, Simulating WAves Nearshore (SWAN). Experiments using Hurricane Ike wind forcing, which impacted the Gulf of Mexico in 2008, illustrate

  20. The Hurricane Imaging Radiometer: Present and Future

    Science.gov (United States)

    Miller, Timothy L.; James, M. W.; Roberts, J. B.; Biswas, S. K.; Cecil, D.; Jones, W. L.; Johnson, J.; Farrar, S.; Sahawneh, S.; Ruf, C. S.; Morris, M.; Uhlhorn, E. W.; Black, P. G.

    2013-01-01

    The Hurricane Imaging Radiometer (HIRAD) is an airborne passive microwave radiometer designed to provide high resolution, wide swath imagery of surface wind speed in tropical cyclones from a low profile planar antenna with no mechanical scanning. Wind speed and rain rate images from HIRAD's first field campaign (GRIP, 2010) are presented here followed, by a discussion on the performance of the newly installed thermal control system during the 2012 HS3 campaign. The paper ends with a discussion on the next generation dual polarization HIRAD antenna (already designed) for a future system capable of measuring wind direction as well as wind speed.

  1. Recombinant disintegrin domain of ADAM15 inhibits the proliferation and migration of Bel-7402 cells

    Energy Technology Data Exchange (ETDEWEB)

    Hou, Y. [Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, 1800 Lihu Rd., Wuxi, Jiangsu 214122 (China); Chu, M. [Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Medicine, Jiangnan University, 1800 Lihu Rd., Wuxi, Jiangsu 214122 (China); Du, F.F.; Lei, J.Y.; Chen, Y.; Zhu, R.Y.; Gong, X.H.; Ma, X. [Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, 1800 Lihu Rd., Wuxi, Jiangsu 214122 (China); Jin, J., E-mail: jinjian31@126.com [Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, 1800 Lihu Rd., Wuxi, Jiangsu 214122 (China)

    2013-06-14

    Highlights: •rhddADAM15 inhibited the proliferation and migration of Bel-7402 cells. •rhddADAM15 inhibited growth and metastasis of Bel-7402 cells in zebrafish xenograft. •rhddADAM15 induced apoptosis in Bel-7402 cells and somatic cells of zebrafish. •Cell-cycle in Bel-7402 cells showed a partial G{sub 2}/S arrest. •Activity of caspases 8, 9 and 3 was increased in rhddADAM15-treated Bel-7402 cells. -- Abstract: ADAM15 (A Disintegrin And Metalloproteinase 15), a transmembrane protein containing seven domains, interacts with some integrins via its disintegrin domain and overexpresses in many solid tumors. In this study, the effect of the recombinant human disintegrin domain (rhddADAM15) on the proliferation and migration of Bel-7402 cells was evaluated in vitro and in vivo in zebrafish xenografts. rhddADAM15 (4 μM) severely inhibited the proliferation and migration of Bel-7402 cells, inducing a partial G{sub 2}/S arrest and morphological nucleus changes of apoptosis. Moreover, the activity of caspases 8, 9 and 3 in Bel-7402 cells was increased. In addition, the zebrafish was used as a model for apoptosis-induction and tumor-xenograft. rhddADAM15 (1 pM) inhibited the growth and metastasis of Bel-7402 cell xenografts in zebrafish and a lower concentration (0.1 pM) induced severe apoptosis in the somatic cells of zebrafish. In conclusion, our data identified rhddADAM15 as a potent inhibitor of tumor growth and metastasis, making it a promising tool for use in anticancer treatment.

  2. ADAM: A computer program to simulate selective-breeding schemes for animals

    DEFF Research Database (Denmark)

    Pedersen, L D; Sørensen, A C; Henryon, M

    2009-01-01

    ADAM is a computer program that models selective breeding schemes for animals using stochastic simulation. The program simulates a population of animals and traces the genetic changes in the population under different selective breeding scenarios. It caters to different population structures, gen......, genetic models, selection strategies, and mating designs. ADAM can be used to evaluate breeding schemes and generate genetic data to test statistical tools......ADAM is a computer program that models selective breeding schemes for animals using stochastic simulation. The program simulates a population of animals and traces the genetic changes in the population under different selective breeding scenarios. It caters to different population structures...

  3. Hedzhirovanije / Ivan Luiska

    Index Scriptorium Estoniae

    Luiska, Ivan

    2001-01-01

    Ettevõtluses levinuim riskide vähendamise meetod on riskiturve - "hedging", mis seisneb selles, et optsiooni- või futuuribörsil sooritatakse valuuta või väärtpaberitehinguid, et kindlustada ettevõtete hindade kõikumise vastu

  4. Hedzhirovanije / Ivan Luiska

    Index Scriptorium Estoniae

    Luiska, Ivan

    2001-01-01

    Ettevõtluses levinuim riskide vähendamise meetod on riskiturve - "hedging", mis seisneb selles, et optsiooni- või futuuribörsil sooritatakse valuuta või väärtpaberitehinguid, et kindlustada ettevõtete hindade kõikumise vastu

  5. Ohutus / Ivan Kappanen

    Index Scriptorium Estoniae

    Kappanen, Ivan

    2004-01-01

    Ilmunud ka: 2003 : annual report : [Eesti Raudtee]. - Tallinn, 2004, lk. 37-39; 2003 : godovoi ottshjot : [Eesti Raudtee]. - Tallinn, 2004, lk. 37-39. 2003. aastal registreeriti Eesti Raudteel kokku 8 töötraumat ja 17 raudteeveeremi kokkupõrget autotranspordiga. Diagrammid

  6. Apparent reduction of ADAM10 in scrapie-infected cultured cells and in the brains of scrapie-infected rodents.

    Science.gov (United States)

    Chen, Cao; Lv, Yan; Zhang, Bao-Yun; Zhang, Jin; Shi, Qi; Wang, Jing; Tian, Chan; Gao, Chen; Xiao, Kang; Ren, Ke; Zhou, Wei; Dong, Xiao-Ping

    2014-12-01

    It has been described that A disintegrin and metalloproteinase (ADAM10) may involve in the physiopathology of prion diseases, but the direct molecular basis still remains unsolved. In this study, we confirmed that ADAM10 was able to cleave recombinant human prion protein in vitro. Using immunoprecipitation tests (IP) and immunofluorescent assays (IFA), reliable molecular interaction between the native cellular form of PrP (PrP(C)) and ADAM10 was observed not only in various cultured neuronal cell lines but also in brain homogenates of healthy hamsters and mice. Only mature ADAM10 (after removal of its prodomain) molecules showed the binding activity with the native PrP(C). Remarkably more prion protein (PrP)-ADAM10 complexes were detected in the membrane fraction of cultured cells. In the scrapie-infected SMB cell model, the endogenous ADAM10 levels, especially the mature ADAM10, were significantly decreased in the fraction of cell membrane. IP and IFA tests of prion-infected SMB-S15 cells confirmed no detectable PrP-ADAM10 complex in the cellular lysates and PrP-ADAM10 co-localization on the cell surface. Furthermore, we demonstrated that the levels of ADAM10 in the brain homogenates of scrapie agent 263K-infected hamsters and agent ME7-infected mice were also almost diminished at the terminal stage, showing time-dependent decreases during the incubation period. Our data here provide the solid molecular basis for the endoproteolysis of ADAM10 on PrP molecules and interaction between ADAM10 and PrP(C). Obvious loss of ADAM10 during prion infection in vitro and in vivo highlights that ADAM10 may play essential pathophysiological roles in prion replication and accumulation.

  7. Modulation of CD163 expression by metalloprotease ADAM17 regulates porcine reproductive and respiratory syndrome virus entry.

    Science.gov (United States)

    Guo, Longjun; Niu, Junwei; Yu, Haidong; Gu, Weihong; Li, Ren; Luo, Xiaolei; Huang, Mingming; Tian, Zhijun; Feng, Li; Wang, Yue

    2014-09-01

    As a consequence of their effects on ectodomain shedding, members of the A disintegrin and metalloprotease (ADAM) family have been implicated in the control of various cellular processes. Although ADAM family members are also involved in cancer, inflammation, and other pathologies, it is unclear whether they affect porcine reproductive and respiratory syndrome virus (PRRSV) infection. Here, we demonstrate for the first time that inhibition of ADAM17 enhances PRRSV entry in Marc-145 and porcine alveolar macrophages (PAMs). We also demonstrate that the inhibition of ADAM17 upregulates membrane CD163 expression, a putative PRRSV receptor that is exogenously expressed in BHK-21 and endogenously expressed in Marc-145 and PAMs. Furthermore, overexpression of ADAM17 induced downregulation of CD163 expression and a reduction in PRRSV infection, whereas ablation of ADAM17 expression using specific small interfering RNA resulted in upregulation of CD163 expression with a corresponding increase in PRRSV infection. These ADAM17-mediated effects were confirmed with PRRSV nonpermissive BHK-21 cells transfected with CD163 cDNA. Overall, these findings indicate that ADAM17 downregulates CD163 expression and hinders PRRSV entry. Hence, downregulation of ADAM17 particular substrates may be an additional component of the anti-infection defenses. ADAM17 is one of the important membrane-associated metalloproteases that mediate various cellular events, as well as inflammation, cancer, and other pathologies. Here, we investigate for the first time the role of the metalloprotease ADAM17 in PRRSV infection. By using inhibitor and genetic modification methods, we demonstrate that ADAM17 negatively regulate PRRSV entry by regulating its substrate(s). More specifically, ADAM 17 mediates the downregulation of the PRRSV cellular receptor CD163. The reduction in CD163 expression represents another component of the anti-infection response initiated by ADAM17. Copyright © 2014, American Society

  8. Hurricane Sandy science plan: coastal impact assessments

    Science.gov (United States)

    Stronko, Jakob M.

    2013-01-01

    Hurricane Sandy devastated some of the most heavily populated eastern coastal areas of the Nation. With a storm surge peaking at more than 19 feet, the powerful landscape-altering destruction of Hurricane Sandy is a stark reminder of why the Nation must become more resilient to coastal hazards. In response to this natural disaster, the U.S. Geological Survey (USGS) received a total of $41.2 million in supplemental appropriations from the Department of the Interior (DOI) to support response, recovery, and rebuilding efforts. These funds support a science plan that will provide critical scientific information necessary to inform management decisions for recovery of coastal communities, and aid in preparation for future natural hazards. This science plan is designed to coordinate continuing USGS activities with stakeholders and other agencies to improve data collection and analysis that will guide recovery and restoration efforts. The science plan is split into five distinct themes: coastal topography and bathymetry, impacts to coastal beaches and barriers, impacts of storm surge, including disturbed estuarine and bay hydrology, impacts on environmental quality and persisting contaminant exposures, impacts to coastal ecosystems, habitats, and fish and wildlife. This fact sheet focuses assessing impacts to coastal beaches and barriers.

  9. Estimating hurricane hazards using a GIS system

    Directory of Open Access Journals (Sweden)

    A. Taramelli

    2008-08-01

    Full Text Available This paper develops a GIS-based integrated approach to the Multi-Hazard model method, with reference to hurricanes. This approach has three components: data integration, hazard assessment and score calculation to estimate elements at risk such as affected area and affected population. First, spatial data integration issues within a GIS environment, such as geographical scales and data models, are addressed. Particularly, the integration of physical parameters and population data is achieved linking remotely sensed data with a high resolution population distribution in GIS. In order to assess the number of affected people, involving heterogeneous data sources, the selection of spatial analysis units is basic. Second, specific multi-hazard tasks, such as hazard behaviour simulation and elements at risk assessment, are composed in order to understand complex hazard and provide support for decision making. Finally, the paper concludes that the integrated approach herein presented can be used to assist emergency management of hurricane consequences, in theory and in practice.

  10. A Simulation Tool for Hurricane Evacuation Planning

    Directory of Open Access Journals (Sweden)

    Daniel J. Fonseca

    2009-01-01

    Full Text Available Atlantic hurricanes and severe tropical storms are a serious threat for the communities in the Gulf of Mexico region. Such storms are violent and destructive. In response to these dangers, coastal evacuation may be ordered. This paper describes the development of a simulation model to analyze the movement of vehicles through I-65, a major US Interstate highway that runs north off the coastal City of Mobile, Alabama, towards the State of Tennessee, during a massive evacuation originated by a disastrous event such a hurricane. The constructed simulation platform consists of a primary and two secondary models. The primary model is based on the entry of vehicles from the 20 on-ramps to I-65. The two secondary models assist the primary model with related traffic events such as car breakdowns and accidents, traffic control measures, interarrival signaling, and unforeseen emergency incidents, among others. Statistical testing was performed on the data generated by the simulation model to indentify variation in relevant traffic variables affecting the timely flow of vehicles travelling north. The performed statistical analysis focused on the closing of alternative on-ramps throughout the Interstate.

  11. Weathering the storm: hurricanes and birth outcomes.

    Science.gov (United States)

    Currie, Janet; Rossin-Slater, Maya

    2013-05-01

    A growing literature suggests that stressful events in pregnancy can have negative effects on birth outcomes. Some of the estimates in this literature may be affected by small samples, omitted variables, endogenous mobility in response to disasters, and errors in the measurement of gestation, as well as by a mechanical correlation between longer gestation and the probability of having been exposed. We use millions of individual birth records to examine the effects of exposure to hurricanes during pregnancy, and the sensitivity of the estimates to these econometric problems. We find that exposure to a hurricane during pregnancy increases the probability of abnormal conditions of the newborn such as being on a ventilator more than 30min and meconium aspiration syndrome (MAS). Although we are able to reproduce previous estimates of effects on birth weight and gestation, our results suggest that measured effects of stressful events on these outcomes are sensitive to specification and it is preferable to use more sensitive indicators of newborn health. Copyright © 2013 Elsevier B.V. All rights reserved.

  12. Dynamics and Predictability of Hurricane Dolly (2008)

    Science.gov (United States)

    Fang, J.; Zhang, F.; Weng, Y.

    2008-12-01

    Through several cloud-resolving simulations with the Weather Research and Forecast (WRF-ARW) model, this study examines the dynamics and predictability of Hurricane Dolly (2008) with an emphasis on its initial development (around the time being declared as a tropical storm) and subsequent rapid intensification entering into the Gulf of Mexico. These WRF simulations include three that are directly initialized with the operational NCEP GFS analyses at 06, 12 and 18Z 20 July 2008, respectively (EXP06, EXP12, EXP18) and another the same as EXP06 except that the airborne Doppler velocity observations by a NOAA P3 aircraft during 12-15Z are assimilated with an ensemble-Kalman filter (ENKF06). Among the four experiments, only EXP06 fails to capture the rapid intensification and fails to develop the tropical storm into a mature hurricane. Preliminary comparison between the simulated fields of EXP06 and the GFS analysis at 12Z (e.g., IC of EXP12) indicates that large scale features favorable to the tropical cyclogenesis cannot be properly simulated in EXP06. The initial disturbance is rather weak positioned too far south-west that is far away from the primary convective. However, after the airborne radar data during 12-15Z are assimilated into the model, (from EXP06 into ENKF06), the ENKF06 simulation is greatly improved in that a well-organized warm-core vortex appears at the low level right after radar assimilation, which subsequently developed into a hurricane consistent with timing, track and intensity of observations. Interestingly, there are significant differences in the initial vortex position, structure and evolution among the three simulations (EXP12, EXP18, ENKF06) that all eventually develop a mature hurricane along the observed track (before landfall) with right timing after enters into the Gulf of Mexico. At 18Z 20 July, there is no apparent initial low-level cyclonic vortex in EXP12 and EXP18 (that is assimilated into ENKF06 due to radar observations

  13. Geologic record of Hurricane impacts on the New Jersey coast

    Science.gov (United States)

    Nikitina, Daria; Horton, Benjamin; Khan, Nicole; Clear, Jennifer; Shaw, Timothy; Enache, Mihaela; Frizzera, Dorina; Procopio, Nick; Potapova, Marina

    2016-04-01

    Hurricanes along the US Atlantic coast have caused significant damage and loss of human life over the last century. Recent studies suggest that intense-hurricane activity is closely related to changes of sea surface temperatures and therefore the risk of hurricane strikes may increase in the future. A clear understanding of the role of recent warming on tropical cyclone activity is limited by the shortness of the instrumental record. However, the sediment preserved beneath coastal wetlands is an archive of when hurricanes impacted the coast. We present two complimenting approaches that help to extend pre-historic record and assess frequency and intensity of hurricane landfalls along the New Jersey cost; dating overwash deposits and hurricane-induced salt-marsh erosion documented at multiple sites. The stratigraphic investigation of estuarine salt marshes in the southern New Jersey documented seven distinctive erosion events that correlate among different sites. Radiocarbon dates suggest the prehistoric events occurred in AD 558-673, AD 429-966, AD 558-673, Ad 1278-1438, AD 1526-1558 or AD 1630-1643 (Nikitina et al., 2014). Younger sequences correspond with historical land-falling hurricanes in AD 1903 and AD 1821 or AD 1788. Four events correlate well with barrier overwash deposits documented along the New Jersey coast (Donnelley et al., 2001 and 2004). The stratigraphic sequence of salt High resolution sedimentary-based reconstructions of past intense-hurricane landfalls indicate that significant variability in the frequency of intense hurricanes occurred over the last 2000 years.

  14. Studying On The Emulate of Servo in NC Based On ADAMS/MATLAB%数控伺服系统的ADAMS/MATLAB联合仿真研究

    Institute of Scientific and Technical Information of China (English)

    邢伟; 周西军

    2007-01-01

    将机械系统仿真分析工具同控制系统设计仿真软件有机地连接起来,利用ADAMS/Controls模块对数控机床X-Y工作平台的进给机械系统进行了建模、通过ADAMS/View或ADAMS/Solver中的信息文件或启动文件,确定ADAMS的输入和输出,通过定义输入和输出,实现了ADAMS和MATLAB控制程序之间的闭环通信,最终实现了复杂机电系统联合仿真.

  15. A delay differential equation solver based on the parallel Adams algorithms

    Institute of Scientific and Technical Information of China (English)

    ChengjianZHANG; HongbingYU

    2001-01-01

    This paper constructs a class of parallel Adams algorithms for the systems of delay differential equations.The results on convergence and stability are given.The theoretical analysis and numerical test shows that this algorithm is effect and comparable.

  16. Highlighting High Performance: Adam Joseph Lewis Center for Environmental Studies, Oberlin College, Oberlin, Ohio

    Energy Technology Data Exchange (ETDEWEB)

    None

    2002-11-01

    Oberlin College’s Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials

  17. 76 FR 45600 - Columbia National Wildlife Refuge, Adams and Grant Counties, WA; Draft Comprehensive Conservation...

    Science.gov (United States)

    2011-07-29

    ... Fish and Wildlife Service Columbia National Wildlife Refuge, Adams and Grant Counties, WA; Draft Comprehensive Conservation Plan and Environmental Assessment AGENCY: Fish and Wildlife Service, Interior. ACTION... wildlife management, conservation, legal mandates, and our policies. In addition to outlining...

  18. Review: Adam Fforde: Coping with Facts: A Skeptic’s Guide to the Problem of Development

    Directory of Open Access Journals (Sweden)

    Michael Waibel

    2011-01-01

    Full Text Available Review of the Monograph: Fforde, Adam (2009, Coping with Facts: A Skeptic’s Guide to the Problem of Development, Bloomfield, CT: Kumarian Pr Inc. ; ISBN-13: 978-1565492684, 246 pages

  19. ADAM 10 expression in primary uveal melanoma as prognostic factor for risk of metastasis.

    Science.gov (United States)

    Caltabiano, Rosario; Puzzo, Lidia; Barresi, Valeria; Ieni, Antonio; Loreto, Carla; Musumeci, Giuseppe; Castrogiovanni, Paola; Ragusa, Marco; Foti, Pietro; Russo, Andrea; Longo, Antonio; Reibaldi, Michele

    2016-11-01

    Uveal melanoma is the most frequent primary intraocular neoplasm in adults. Although malignant melanoma may be located at any point in the uveal tract, the choroid and ciliary body are more frequent locations than the iris. In the present study, we examined ADAM10 expression levels in primary uveal melanoma both with and without metastasis, and we evaluated their association with other high risk characteristics for metastasis in order to assess if ADAM10 can be used to predict metastasis. This study included a total of 52 patients, 23 men and 29 women, with uveal melanoma. A significantly high expression of ADAM-10 was seen in patients with metastasis (11/13, 84.6%), but not in patients without metastasis (15/39, 38.5%). In conclusion we found that ADAM10 expression was associated with a more rapid metastatic progression confirming its role in uveal melanoma metastasis.

  20. FlipADAM: a potential new SPECT imaging agent for the serotonin transporter

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Julie L.; Deutsch, Eric C. [Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 (United States); Oya, Shunichi [Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 (United States); Kung, Hank F., E-mail: kunghf@gmail.co [Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 (United States); Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 (United States)

    2010-07-15

    Introduction: Single photon emission computed tomography (SPECT) imaging of the serotonin transporter (SERT) in the brain is a useful tool for examining normal physiological functions and disease states involving the serotonergic system. The goal of this study was to develop an improved SPECT radiotracer with faster kinetics than the current leading SPECT tracer, [{sup 123}I]ADAM, for selective SERT imaging. Methods: The in vitro binding affinities of (2-(2'-((dimethylamino)methyl)-4'-iodophenylthio)benzenamine) (FlipADAM) (1c), were determined using Hampshire pig kidney cells stably overexpressing the serotonin, norepinephrine (NET) or dopamine transporter (DAT). Localization of [{sup 125}I]FlipADAM (1c) was evaluated through biodistribution and autoradiography in male Sprague Dawley rats, and the specificity of binding was assessed by injecting selective SERT or NET inhibitors prior to [{sup 125}I]FlipADAM (1c). Results: FlipADAM (1c) displayed a high binding affinity for SERT (K{sub i}=1.0 nM) and good selectivity over NET and DAT binding (43-fold and 257-fold, respectively). [{sup 125}I]FlipADAM (1c) successfully penetrated the blood brain barrier, as evidenced by the brain uptake at 2 min (1.75% dose/g). [{sup 125}I]FlipADAM(1c) also had a good target to non-target (hypothalamus/cerebellum) ratio of 3.35 at 60 min post-injection. In autoradiography studies, [{sup 125}I]FlipADAM (1c) showed selective localization in SERT-rich brain regions such as the thalamic nuclei, amygdala, dorsal raphe nuclei and other areas. Conclusion: [{sup 125}I]FlipADAM (1c) exhibited faster clearance from the brain and time to binding equilibrium when compared to [{sup 125}I]2-(2'-((dimethylamino)methyl)-phenylthio)-5-iodophenylamine [{sup 125}I]ADAM (1b) and a higher target to non-target ratio when compared to [{sup 125}I]5-iodo-2-(2'-((dimethylamino)methyl)-phenylthio)benzyl alcohol [{sup 125}I]IDAM (1a). Therefore, [{sup 123}I]FlipADAM (1c) may be an improved