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Sample records for hunter college ny

  1. Hunter College Dance Therapy Masters Program.

    Science.gov (United States)

    Schmais, Claire; White, Elissa Q.

    Described is development of the Hunter College dance therapy 18-month 30-credit masters program involving 33 adult students, (in two classes beginning in 1971 and 1972), an educational model, internship in psychiatric institutions, and preparation of instructional materials. The dance therapist is said to incorporate the psychiatric patient's…

  2. Representation of Self among Chinese College Job-hunters

    Institute of Scientific and Technical Information of China (English)

    徐嗣群

    2010-01-01

    @@ Introduction: Some of their researches (Booher, 1988; Smith and Bernhardt, 1996; Munter, 2006) have been concentrated on teaching students writing skills.On the other hand, some of their researches (Lakoff, 1975; Labov, 1990; Coates, 1998) have been carried on about identifying and instantiating possible differences in linguistic styles between males and females.However, little work has been undertaken on investigating gender differences reflected in business letters writing, especially job-application letter, by analyzing the genre components and politeness strategies.In this project, by providing a content analysis of 20 job application letters written by Chinese college job applicants, I try to explore the differences between Chinese male and female college job hunters presented in their job application letters.

  3. Indice de Indices en la Biblioteca de Hunter College para el Estudiante Hispano.

    Science.gov (United States)

    Talero Bielsa, Alberto; And Others

    Designed for Spanish-speaking students of Hunter College of the City University of New York, this guide explains the use of 70 English-language indexes found in the college library. The explanations are given in Spanish in order to simplify the process of library research for students who are not completely comfortable with English. Each index is…

  4. 77 FR 42510 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY; Correction

    Science.gov (United States)

    2012-07-19

    ... National Park Service Notice of Inventory Completion: New York University College of Dentistry, New York... College of Dentistry, New York, NY. The human remains were removed from Bronx County, NY. This notice is... was made by New York University College of Dentistry professional staff in consultation...

  5. 75 FR 36110 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

    Science.gov (United States)

    2010-06-24

    ... National Park Service Notice of Inventory Completion: New York University College of Dentistry, New York... Dentistry, New York, NY. The human remains were removed from Broward and Levy Counties, FL, and an unknown... assessment of the human remains was made by the New York University College of Dentistry professional...

  6. 75 FR 33327 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

    Science.gov (United States)

    2010-06-11

    ... National Park Service Notice of Inventory Completion: New York University College of Dentistry, New York... Dentistry, New York, NY. The human remains were removed from the Allred Bluff and Salts Bluff Rockshelters... assessment of the human remains was made by the New York University College of Dentistry professional...

  7. 75 FR 33329 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

    Science.gov (United States)

    2010-06-11

    ... National Park Service Notice of Inventory Completion: New York University College of Dentistry, New York... Dentistry, New York, NY. The human remains were removed from Lovelock Cave, Churchill County, NV. This... remains was made by the New York University College of Dentistry professional staff in consultation...

  8. The Catalyst Scholarship Program at Hunter College. A Partnership among Earth Science, Physics, Computer Science and Mathematics

    Science.gov (United States)

    Salmun, Haydee; Buonaiuto, Frank

    2016-01-01

    The Catalyst Scholarship Program at Hunter College of The City University of New York (CUNY) was established with a four-year award from the National Science Foundation (NSF) to fund scholarships to 40 academically talented but financially disadvantaged students majoring in four disciplines of science, technology, engineering and mathematics…

  9. Rust City: Brockport College Apartments, Brockport, N.Y.

    Science.gov (United States)

    Stephens, Suzanne

    1975-01-01

    To hold down construction costs of student housing, Brockport College decided on a fixed-cost competition, in which architects had to team up with contractors. The winning firm used a French industrialized building system and exterior panels of weathered steel to construct a village of 27 four-story buildings. (JG)

  10. Hunter syndrome

    Science.gov (United States)

    ... Diagnosis and Treatment . 5th ed. New York, NY: Springer; 2012:chap 40. Read More Breathing difficulty Chromosome ... medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- ...

  11. Ny uddannelse til senioridrætskonsulent styrker samarbejdet mellem DGI og University College Lillebælt

    DEFF Research Database (Denmark)

    Bendsen, Aksel

    2008-01-01

    I samarbejde med Danske Gymnastik og Idrætsforeninger har University College Lillebælt udviklet en ny uddannelse til senioridrætskonsulent. Uddannelsen startede i Odense i efteråret 2008. At udvikle uddannelsen involverede flere parter. Det krævede et stort samarbejde at få alle disse forskellige...... menneskers ønsker og behov til at resultere i en uddannelse med et klart sigte og et kvalificeret indhold. Det er imidlertid et krav til de nye professionshøjskoler, at de kan løse den slags opgaver. I dag er den nye uddannelse et bevis på, at University College Lillebælt har disse kompetencer....

  12. Vulnerable Hunter

    Directory of Open Access Journals (Sweden)

    Md.Asha Begum

    2016-05-01

    Full Text Available This project "VULNERABLE HUNTER" application main aim is to detect risk in our mobile applications. This application contains modules like Fetch Application, Generate Score, Uninstall and Display Graph. Through this application it detects risk so that this application is very useful to smart phone users Now-a-days so many people are using smart phones and people are crazy about new apps. But by installing all the applications into our mobile may reduce its performance. Some apps contain more risk. But user may not know the effects that are caused by the app which is installed until the performance of mobile is reduced. With the prosperity of the Android app economy, many apps have been published and sold in various markets. However, short development applications and insufficient security development apps have led to many vulnerable apps. So to reduce these type of problems Vulnerable Hunter is proposed. Through the proposed application user can see which application is risky and then the user may uninstall that application. The main advantage of designing this app is without internet also the users will use this application. Users also feel more convenient to work with mobile apps.

  13. 75 FR 52021 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

    Science.gov (United States)

    2010-08-24

    ... National Park Service Notice of Inventory Completion: New York University College of Dentistry, New York... of an inventory of human remains in the possession of the New York University College of Dentistry... made by New York University College of Dentistry professional staff in consultation...

  14. 77 FR 42513 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

    Science.gov (United States)

    2012-07-19

    ... National Park Service Notice of Inventory Completion: New York University College of Dentistry, New York... of Dentistry has completed an inventory of human remains, in consultation with the appropriate Indian... the human remains may contact the New York University College of Dentistry. Disposition of the...

  15. 77 FR 42507 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

    Science.gov (United States)

    2012-07-19

    ... National Park Service Notice of Inventory Completion: New York University College of Dentistry, New York... of Dentistry has completed an inventory of human remains, in consultation with the appropriate Indian... the human remains may contact the New York University College of Dentistry. Disposition of the...

  16. 77 FR 42508 - Notice of Inventory Completion: New York University College of Dentistry, New York, NY

    Science.gov (United States)

    2012-07-19

    ... National Park Service Notice of Inventory Completion: New York University College of Dentistry, New York... of Dentistry has completed an inventory of human remains, in consultation with the appropriate Indian... the human remains may contact the New York University College of Dentistry. Repatriation of the...

  17. A synergistic effort among geoscience, physics, computer science and mathematics at Hunter College of CUNY as a Catalyst for educating Earth scientists.

    Science.gov (United States)

    Salmun, H.; Buonaiuto, F. S.

    2016-12-01

    The Catalyst Scholarship Program at Hunter College of The City University of New York (CUNY) was established with a four-year award from the National Science Foundation (NSF) to fund scholarships for academically talented but financially disadvantaged students majoring in four disciplines of science, technology, engineering and mathematics (STEM). Led by Earth scientists the Program awarded scholarships to students in their junior or senior years majoring in computer science, geosciences, mathematics and physics to create two cohorts of students that spent a total of four semesters in an interdisciplinary community. The program included mentoring of undergraduate students by faculty and graduate students (peer-mentoring), a sequence of three semesters of a one-credit seminar course and opportunities to engage in research activities, research seminars and other enriching academic experiences. Faculty and peer-mentoring were integrated into all parts of the scholarship activities. The one-credit seminar course, although designed to expose scholars to the diversity STEM disciplines and to highlight research options and careers in these disciplines, was thematically focused on geoscience, specifically on ocean and atmospheric science. The program resulted in increased retention rates relative to institutional averages. In this presentation we will discuss the process of establishing the program, from the original plans to its implementation, as well as the impact of this multidisciplinary approach to geoscience education at our institution and beyond. An overview of accomplishments, lessons learned and potential for best practices will be presented.

  18. Hunters' motivations and values:

    DEFF Research Database (Denmark)

    Radder, Laetitia; Bech-Larsen, Tino

    2008-01-01

    This article examines the values and motivations of South African biltong hunters. A hierarchical value map of associations between attributes, consequences and values resulted from laddering interviews with 34 hunters. The Means-End Chain approach proved useful in identifying: (a) personal values......, (b) wildlife value orientations, and (c) motivations associated with desired benefits and satisfactions. Values reflected socialization, achievement, stimulation, hedonism, universalism, and conformity. Materialism, attraction/interest, respect, environmentalism, and rational/scientific were...... the predominant wildlife value orientations. Motivations included male identity, escape, appreciation of nature, and bonding with family and friends. The study refuted perceptions that biltong hunters primarily hunt for the meat or for the sake of killing an animal....

  19. Hunters' motivations and values:

    DEFF Research Database (Denmark)

    Radder, Laetitia; Bech-Larsen, Tino

    2008-01-01

    This article examines the values and motivations of South African biltong hunters. A hierarchical value map of associations between attributes, consequences and values resulted from laddering interviews with 34 hunters. The Means-End Chain approach proved useful in identifying: (a) personal values......, (b) wildlife value orientations, and (c) motivations associated with desired benefits and satisfactions. Values reflected socialization, achievement, stimulation, hedonism, universalism, and conformity. Materialism, attraction/interest, respect, environmentalism, and rational/scientific were...... the predominant wildlife value orientations. Motivations included male identity, escape, appreciation of nature, and bonding with family and friends. The study refuted perceptions that biltong hunters primarily hunt for the meat or for the sake of killing an animal....

  20. The Higgs hunter's guide

    CERN Document Server

    Gunion, John F; Haber, Howard E; Kane, Gordon L

    1989-01-01

    The Higgs Hunter's Guide is a definitive and comprehensive guide to the physics of Higgs bosons. In particular, it discusses the extended Higgs sectors required by those recent theoretical approaches that go beyond the Standard Model, including supersymmetry and superstring-inspired models.

  1. Ny arkitektur for nordmenn i Iowa. Arkitekt C.H. Griese, Luther College og kirker i 1860-årene

    Directory of Open Access Journals (Sweden)

    Jens Christian Eldal

    2015-12-01

    Full Text Available The Norwegian Evangelical-Lutheran Church in America decided in 1861 to build their first college close to the western frontier of The Upper Midwest. The site chosen was a bluff above Upper Iowa River, highly visible from Decorah, a small town founded only 12 years earlier, few years after the first settlers arrived. The college building became a relatively vast structure erected between 1862 and 1865, completed to its originally planned symmetrical composition in 1874. The building style and its composition were common among American colleges and universities further east in the US. It is also demonstrated how the Luther College building façade in composition and detailing shows clear influences from a specific German building. This particular building has been designated as especially typical of the German Rundbogenstil (Style of the Rounded Arch with its great mix of various stylistic elements. The architect was known as C. H. Griese from Cleveland, Ohio. He is identified as Charles Henry Griese (1821–1909, who immigrated from Germany about 1850 and was known as a mason and contractor, from now on also as an architect. In 1869, Griese also designed the three Norwegian Lutheran churches of Washington Prairie, Stavanger and Glenwood in rural Decorah. They represented a Neo Gothic style which was new to the area, and had an evident architectural character contrasting the more ordinary vernacular churches in the area. They signify a change of style and, like the college building, they demonstrate architectural ambitions new to these Norwegians, giving insight also into the general architectural and vernacular development in the area.

  2. Neurogenic bladder in Hunter's syndrome.

    Science.gov (United States)

    Koyama, K; Moda, Y; Sone, A; Tanaka, H; Hino, Y

    1994-01-01

    We encountered a rare patient with Hunter's syndrome who exhibited urinary retention as a result of a neurogenic bladder, uninhibited detrusor contractions, and detrusor-sphincter dyssynergia. Neurological findings were consistent with cervical myelopathy and cervical MR imaging showed very narrow segments at the cord level C2-4. We speculate that this Hunter's syndrome patient has cervical myelopathy and that this neurological dysfunction causes the neurogenic bladder. PMID:8014981

  3. The Infrared Hunter

    Science.gov (United States)

    2006-01-01

    [figure removed for brevity, see original site] [figure removed for brevity, see original site] Figure 1Figure 2 This image composite compares infrared and visible views of the famous Orion nebula and its surrounding cloud, an industrious star-making region located near the hunter constellation's sword. The infrared picture is from NASA's Spitzer Space Telescope, and the visible image is from the National Optical Astronomy Observatory, headquartered in Tucson, Ariz. In addition to Orion, two other nebulas can be seen in both pictures. The Orion nebula, or M42, is the largest and takes up the lower half of the images; the small nebula to the upper left of Orion is called M43; and the medium-sized nebula at the top is NGC 1977. Each nebula is marked by a ring of dust that stands out in the infrared view. These rings make up the walls of cavities that are being excavated by radiation and winds from massive stars. The visible view of the nebulas shows gas heated by ultraviolet radiation from the massive stars. Above the Orion nebula, where the massive stars have not yet ejected much of the obscuring dust, the visible image appears dark with only a faint glow. In contrast, the infrared view penetrates the dark lanes of dust, revealing bright swirling clouds and numerous developing stars that have shot out jets of gas (green). This is because infrared light can travel through dust, whereas visible light is stopped short by it. The infrared image shows light captured by Spitzer's infrared array camera. Light with wavelengths of 8 and 5.8 microns (red and orange) comes mainly from dust that has been heated by starlight. Light of 4.5 microns (green) shows hot gas and dust; and light of 3.6 microns (blue) is from starlight.

  4. Planet Hunters: A Status Report

    Science.gov (United States)

    Schwamb, Megan E.; Orosz, J. A.; Carter, J. A.; Fischer, D. A.; Howard, A. W.; Crepp, J. R.; Welsh, W. F.; Kaib, N. A.; Lintott, C. J.; Terrell, D.; Jek, K. J.; Gagliano, R.; Parrish, M.; Smith, A. M.; Lynn, S.; Brewer, J. M.; Giguere, M. J.; Schawinski, K.; Simpson, R. J.

    2012-10-01

    The Planet Hunters (http://www.planethunters.org) citizen science project uses the power of human pattern recognition via the World Wide Web to identify transits in the Kepler public data. Planet Hunters uses the Zooniverse (http://www.zooniverse.org) platform to present visitors to the Planet Hunters website with a randomly selected 30-day light curve segment from one of Kepler's 160,000 target stars. Volunteers are asked to draw boxes to mark the locations of visible transits with multiple independent classifiers reviewing each 30-day light curve segment. Since December 2010, more than 170,000 members of the general public have participated in Planet Hunters contributing over 12.5 million classifications searching the 1 1/2 years of publicly released Kepler observations. Planet Hunters is a novel and complementary technique to the automated transit detection algorithms, providing an independent assessment of the completeness of the Kepler exoplanet inventory. We report the latest results from Planet Hunters, highlighting in particular our latest efforts to search for circumbinary planets (planets orbiting a binary star) and single transit events in the first 1.5 years of public Kepler data. We will present a status report of our search of the first 6 Quarters of Kepler data, introducing our new planet candidates and sharing the results of our observational follow-up campaign to characterize these planetary systems. Acknowledgements: MES is supported by a NSF Astronomy and Astrophysics Postdoctoral Fellowship under award AST-1003258. This is research is supported in part by an American Philosophical Society Franklin Grant.

  5. Identification and specialization as a waterfowl hunter

    Science.gov (United States)

    Schroeder, Susan A.; Fulton, David C.; Lawrence, Jeffrey S.; Cordts, Steven D.

    2013-01-01

    Like specialization, identity offers a way for differentiating and understanding recreationists and for gaining insight into the question of participant progression in an activity. We examined how identity related to measures of specialization among lapsed and current waterfowl hunters. Lapsed hunters included those who had purchased a Minnesota waterfowl stamp between 2000 and 2004, but not since this time. Current hunters had purchased a 2010 stamp. Results suggested that some waterfowl hunters specialize and progress toward a waterfowl-hunter identity. Others, however, either hunt for years but never specialize and identify as waterfowl hunters, or move toward but do not attain a waterfowl hunter identity. Individuals who achieve a waterfowl hunter identity may also later relinquish this identity. Identification was associated with increased specialization and resistance to change from a preference for waterfowl hunting. Individuals who had relinquished their identity retained social and knowledge-based commitment to waterfowl hunting, whereas attraction and centrality declined.

  6. Travels with the Fossil Hunters

    Science.gov (United States)

    Whybrow, Peter J.

    2000-04-01

    Whether dodging bullets in West Africa, or rabid dogs in Pakistan, surviving yak-butter tea in Tibet, or eating raw fish in China, the life of a globe-trotting fossil hunter is often hazardous and always filled with surprises. Travels with the Fossil Hunters lets readers share the wonder, joys of discovery, and excitement of these intrepid scientists. Packed with more than 100 beautiful, full-color photographs, the volume takes readers on twelve expeditions to remote parts of the world in search of diverse fossil remains, from those of dinosaurs to human ancestors. Each expedition by paleontologists from London's Natural History Museum reveals the problems and challenges of working in extreme conditions, from the deserts of the Sahara and Yemen to the frozen wastes of Antarctica, from the mountains of India to the forests of Latvia. Along the way they also describe the paleontology and geology of the countries they visit and the scientific reasons for their expeditions. With a foreword from Sir David Attenborough and an introduction from Richard Fortey, this fascinating book will appeal to amateur and professional fossil hunters alike and to readers interested in accounts of exotic locales. Peter Whybrow is a research scientist at the Natural History Museum, London. His research interests include Arabian Miocene vertebrates, paleoclimates, paleogeography, and biotic diversity. He is senior editor with A. Hill of Fossil Vertebrates of Arabia (Yale University Press, New Haven, 1999).

  7. Hunter Valley的诚信%Hunter Valley's Honesty

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ 去年圣诞节假期,我和小T曾和大连狮子一家三口,到悉尼附近知名旅游地Hunter Valley(猎人谷)度过了快乐充实的三天. 我们一行五人在圣诞节那天乘坐提前预订好的马车,大约走访了八、九个大大小小的葡萄洒园.

  8. Hunters in the new millennium”

    DEFF Research Database (Denmark)

    Hansen, Hans Peter

    of the modern world continue to practice hunting? What are the preferences of the modern hunter? How are the preferences and conduct of hunters related to the social and demographic factors? What are the social, political and economical impacts of hunting? What motivates people to hunt? - In spite of the fact...... that hunting is a common source of conflict between different interests, only very few studies has been made to produce knowledge about people hunting for leisure. The survey “Hunters in the new millennium” is an attempt to contribute to a better understanding of hunters and hunting in an increasing urbanized...

  9. Danes - The keen bargain hunters

    DEFF Research Database (Denmark)

    Jensen, Birger Boutrup

    2008-01-01

    New research proves that Danes are keen bargain hunters, and that they do specific price checks before selecting a product.......New research proves that Danes are keen bargain hunters, and that they do specific price checks before selecting a product....

  10. Nye Medier - ny journalistik?

    DEFF Research Database (Denmark)

    Hartley, Jannie Møller

    2009-01-01

    På baggrund af en pilotundersøgelse undersøger denne artikel forskningens hypoteser om netjournalistikken, med særligt fokus på den nordiske litteratur på området. Det argumenteres, at der med netmediet og netavisernes vækst ikke nødvendigvis er tale om ny journalistik; på den ene side bekræfter ...... nogle traditionelle journalistiske rutiner i nyhedsproduktionen.En radikalisering der indikerer, at nyheden i den digitale tidsalder kan ses som en dynamisk proces frem for et statisk produkt. Udgivelsesdato: 2009...

  11. Faglighed + test = ny elevtype

    DEFF Research Database (Denmark)

    Drejer, Claus Munch

    2010-01-01

    Kronikken handler om tiden efter den seneste folkeskolelov, samt de teknikker der indføres i bestræbelserne på at optimere elevernes færdigheder og kundskaber. Siden de dårlige PISA-test i 2000, og specielt 2003, har der været fokus på det kernefaglige, og for at sikre eleverne denne faglighed in...... indføres en række teknikker såsom evaluering, test, trin- og slutmål, der skal sikre at eleverne optimere deres faglighed. Dette peger frem mod en ny elevtype - en præstationsorienteret elev....

  12. Tendenser i ny tysk litteratur

    DEFF Research Database (Denmark)

    Povlsen, Steen Klitgård

    Arbejdspapiret indeholder to foredrag: dels om ny tysk litteraturs forhold til 2. verdenskrig, dels om Pater Handke og hans roman "Don Juan (fortalt af ham selv)......Arbejdspapiret indeholder to foredrag: dels om ny tysk litteraturs forhold til 2. verdenskrig, dels om Pater Handke og hans roman "Don Juan (fortalt af ham selv)...

  13. The hunter a scientific novel

    CERN Document Server

    Genta, Giancarlo

    2013-01-01

    The 24th century: humankind has become a spacefaring civilization, colonizing the solar system and beyond. While no alien forms of life have yet been encountered in this expansion into space, colonists suddenly encounter machines of alien origin - huge robots able to reproduce themselves.  Called replicators by the colonists, they seem to have but a single goal: to destroy all organic life they come in contact with. Since the colonial governments have no means to fight this menace directly, they instead promise huge rewards to whoever destroys a replicator. As a result, the frontier attracts a new kind of adventurers, the Hunters, who work to find and destroy the replicators. Mike Edwards, a skilled young maintenance technician and robotics expert at a faraway outpost, will not only become one of them - but be the very first one to unlock the secret behind the replicators’ origin and mission.   The scientific and technical aspects underlying the plot - in particular space travel, robotics and self-replica...

  14. Hydrology of Hunters Lake, Hernando County, Florida

    Science.gov (United States)

    Henderson, S.E.

    1986-01-01

    The size and shape of Hunters Lake, Florida has been significantly altered by development of the surrounding Spring Hill residential community. The lake is the largest in Hernando County, enlarged by lakeshore excavation and connection to nearby ponds to an area of 360 acres at an average stage of 17.2 ft above sea level. Hunters Lake is naturally a closed lake, but development of Spring Hill has resulted in a surface water outflow from the lake in its southwest corner. Inflow to the lake could occur on the east side during extreme high-water periods. The karst terrain of the Hunters Lake area is internally drained through permeable soils, depressions, and sinkholes, and natural surface drainage is absent. The underlying Floridan aquifer system is unconfined except locally near coastal springs. Flow in the groundwater system is to the west regionally and to the southwest in the immediate area of Hunters Lake. Water level gradients in the groundwater system increase from 1.4 ft/mi east of the lake to about 8 ft/mi southwest of the lake. Hunters Lake is hydraulically connected to the groundwater system, receiving groundwater on the northeast side and losing water to the groundwater system on the southwest side. This close relationship with the groundwater system is demonstrated by graphical and numerical comparison of Hunters Lake stage with water levels in nearby groundwater sites. During 1965-84, the stage of Hunters Lake fluctuated between 12.48 and 20.7 ft above sea level. Because area lakes are all directly affected by groundwater levels, they also show a close relationship with water levels in Hunters Lake. Analysis of water quality data for Hunters Lake indicates that the water of the lake is a soft calcium bicarbonate type with ionic concentrations higher than in water from nearby shallow wells and lower than in water from the Upper Floridan aquifer. Samples collected in 1981-1983 indicate slightly higher levels of ionic concentration than in 1965

  15. Motivations of female Black Hills deer hunters

    Science.gov (United States)

    Gigliotti, Larry M.; Covelli Metcalf, Elizabeth

    2016-01-01

    State fish and wildlife agencies are particularly interested in attracting female participation because of the potential to offset declining participation in hunting. Understanding female hunters’ motivations will be critical for designing effective recruitment and retention programs for women hunters. Although female participation in hunting is increasing, males still outnumber females by about tenfold. Gender differences in deer hunters were explored by comparing ratings of eight motivations (social, nature, excitement, meat, challenge, trophy, extra hunting opportunity, and solitude). Hunter types were defined by hunters’ selection of the most important motivation for why they like Black Hills deer hunting. Overall, females and males were relatively similar in their ratings of the eight motivations, and we found 85% gender similarity in the selection of the most important motivation. Women were slightly more motivated by the food aspect of the hunt while men placed slightly more value on the hunt as a sporting activity.

  16. Promoting Interest in Plant Biology with Biographies of Plant Hunters.

    Science.gov (United States)

    Daisey, Peggy

    1996-01-01

    Describes the use of biographical stories to promote student interest in plant biology. Discusses plant hunters of various time periods, including ancient, middle ages, renaissance, colonial Americas, and 18th and 19th centuries; women plant hunters of the 1800s and early 1900s; and modern plant hunters. Discusses classroom strategies for the…

  17. 32 CFR 636.10 - Hunter Army Airfield vehicle registration.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Hunter Army Airfield vehicle registration. 636.10... Stewart, Georgia § 636.10 Hunter Army Airfield vehicle registration. Personnel assigned or employed at Hunter Army Airfield are required to register their privately owned vehicles within five days...

  18. Native grasses for rehabilitating Hunter Valley minesites

    Energy Technology Data Exchange (ETDEWEB)

    Huxtable, C. [NSW Department of Land and Water Conservation, NSW (Australia)

    1998-04-01

    Introduced plant species, particularly grasses, have long been used to rehabilitate mined land in Australia. Interest in using native species spawned a research project in the Hunter Valley which has demonstrated the suitability of certain native species for rehabilitation and put forward guidelines to enhance the chance of their successful establishment. 4 photos., 1 tab.

  19. Hunters Try to Capture Their Past

    Institute of Scientific and Technical Information of China (English)

    China Daily

    2012-01-01

    Mo Guizhen was 5 when she saw a real bed for the first time.She refused to sleep on it,accustomed as she was to deer furs laid on the ground of hunters' huts in the depths of the Greater Hinggan Mountains in northeastern China.

  20. Hunters syndrom og hørenedsaettelse

    DEFF Research Database (Denmark)

    Kiaer, Eva Kirkegaard; Møller, Troels Reinholdt; Wetke, Randi

    2010-01-01

    functions and language were delayed, and he made audible respiratory sounds and was obviously nasally congested. The boy was referred for further investigations at the Department of Paediatrics. The tests showed that the boy suffered from Hunter Syndrome (MPSII) and he underwent relevant treatment....

  1. Studerende giver ny indsigt til digital byudvikling

    DEFF Research Database (Denmark)

    2016-01-01

    http://studerende.au.dk/studier/fagportaler/arts/aktuelt/nyheder/vis-nyhed/artikel/studerende-giver-ny-indsigt-til-digital-byudvikling/......http://studerende.au.dk/studier/fagportaler/arts/aktuelt/nyheder/vis-nyhed/artikel/studerende-giver-ny-indsigt-til-digital-byudvikling/...

  2. The effects of harvest regulations on behaviors of duck hunters

    Science.gov (United States)

    Haugen, Matthew T.; Powell, Larkin A.; Vrtiska, Mark P.; Pope, Kevin L.

    2015-01-01

    Uncertainty exists as to how duck harvest regulations influence waterfowl hunter behavior. We used the U.S. Fish and Wildlife Service’s Parts Collection Survey to examine how harvest regulations affected behaviors of Central Flyway duck hunters. We stratified hunters into ranked groups based on seasonal harvest and identified three periods (1975–1984, 1988–1993, 2002–2011) that represented different harvest regulations (moderate, restrictive, and liberal, respectively; season length and daily bag limits smallest in restrictive seasons and largest in liberal seasons). We examined variability of seven measures of duck hunter behaviors across the periods: days harvesting ducks, daily harvest, hunter mobility, mallard (Anas platyrhynchos) selectivity, gender selectivity, daily female mallard harvest, and timing of harvest. Hunters reported harvesting ducks on more days, at a higher efficiency, and in slightly more counties during liberal seasons relative to restrictive and moderate seasons. We provide evidence to suggest that future regulation change will affect hunter behaviors.

  3. Udlejers godkendelse af ny erhvervslejer

    DEFF Research Database (Denmark)

    Munk-Hansen, Carsten

    2009-01-01

    I artiklen er taget udgangspunkt i den »klassiske« afståelsessituation, hvor en lejer vil afhænde den i de lejede lokaler drevne virksomhed, og lejeren har afståelsesret til en af udlejer godkendt lejer, uden at kravene til den ny lejer er specificeret. På baggrund af Vestre Landsrets dom af 9/2 ...

  4. Ny industrialisering - et bedre produktmarked

    DEFF Research Database (Denmark)

    Beim, Anne

    2001-01-01

    for byggeriet med titlerne: 1. Bygherren som forandringsagent. 2. Tæt samarbejde i byggedelen. 3. Ny industrialisering. 4. Byg med kommunikation og innovation. Dette debathæfte er nummer tre i rækken og omhandler byggeriets industridel og mulighederne for at fremme en succesfuld industriel produktion....

  5. Wildlife value orientations among hunters, landowners and the general public

    DEFF Research Database (Denmark)

    Gamborg, Christian; Jensen, Frank Søndergaard

    2016-01-01

    . Significant differences in wildlife value orientations were found. Mutualists and distanced dominated in the public; most landowners and hunters were utilitarian followed by pluralist. Male hunters were more utilitarian than female. More active hunters were more utilitarian; hunters belonging to a hunting...... association were more utilitarian than those who did not belong to associations. Full-time farmers were more utilitarian than part-time farmers, and conventional farmers were more utilitarian than organic farmers. No significant difference with regard to residence for all three groups was found. Future...

  6. Radioactive caesium in hunters and their families

    Energy Technology Data Exchange (ETDEWEB)

    Aagren, G.; Bergman, R. [Natonal Defence Research Establishment, Umeaa (Sweden); Drottz-Sjoeberg, B.M. [Center for Risk Research, Stockholm (Sweden); Enander, A. [National Defence Research Establishment, Karlstad (Sweden); Johansson, K.J. [Swedish Univ. of Agricultural Sciences, Uppsala (Sweden)

    1995-12-01

    We have measured the whole-body content of radiocesium in men and women in households, where at least one member is a hunter. Hunter families live to a great extent on forest products, such as mushrooms, berries and meat from game. Measurements were performed in two areas in northern Sweden and in three areas in the middle part of Sweden with deposition levels between 7 to 80 kBq/m{sup 2}. The average whole body content of {sup 137}Cs varied between 0.3 to 1.9 kBq for women and 0.6 to 4.7 kBq for men, depending on the deposition level. Each individual in the measured group was also asked to fill in questionnaire and a food diary to provide complementary information of, e.g., food intake and other life conditions. The single dietary factor most clearly related to whole-body content in these groups is the intake of meat from moose. The best regression model with variables from the questionnaire explained 60% of the variance in the whole-body content of {sup 137}Cs in the measurement group. Some of the variables in this model were deposition level, sex, rate of intake and estimated consumption of moose meat and estimated amount of bilberries in the fridge. 6 refs, 5 figs, 14 tabs.

  7. Duck hunters' perceptions of risk for avian influenza, Georgia, USA.

    Science.gov (United States)

    Dishman, Hope; Stallknecht, David; Cole, Dana

    2010-08-01

    To determine duck hunters'risk for highly pathogenic avian influenza, we surveyed duck hunters in Georgia, USA, during 2007-2008, about their knowledge, attitudes, and practices. We found they engage in several practices that could expose them to the virus. Exposures and awareness were highest for those who had hunted >10 years.

  8. Play as a Foundation for Hunter-Gatherer Social Existence

    Science.gov (United States)

    Gray, Peter

    2009-01-01

    The author offers the thesis that hunter-gatherers promoted, through cultural means, the playful side of their human nature and this made possible their egalitarian, nonautocratic, intensely cooperative ways of living. Hunter-gatherer bands, with their fluid membership, are likened to social-play groups, which people could freely join or leave.…

  9. Attribute-based analysis of hunters' lease preferences.

    Science.gov (United States)

    Hussain, Anwar; Munn, Ian A; Hudson, Darren; West, Ben

    2010-12-01

    Understanding of hunter preferences for hunting lease attributes is important to landowners because such knowledge provides key information for managing and marketing fee-hunting in order to maximize revenues. Premised on this insight, we used attribute based modeling to investigate how hunter preferences for potential leases were influenced by lease and hunter-specific attributes. A mail survey of Mississippi licensed hunters provided the necessary data. Estimation results based on McFadden conditional logit regression suggested that lease attributes including game diversity, lease location relative to hunter residence, lease size, lease duration and lease rate influenced willingness to pay for additional units of lease attributes. Depending on the specific levels of these attributes, WTP could vary as much as $5.70 per acre. Of the hunter-specific attributes, age and income significantly influenced hunter decision to buy a lease or opt for status quo. Results of this study should assist landowners in increasing financial returns from fee-hunting endeavors through appropriate changes to their hunting access policies and wildlife management activities in response to hunter preferences regarding lease attributes.

  10. Wild boar hunters profile in Shimane prefecture, western Japan

    Directory of Open Access Journals (Sweden)

    Ueda, G.

    2005-12-01

    Full Text Available Wild boars have been expanding their range and seriously damage agricultural crops all over Japan. Such situation is obvious in Shimane Prefecture, western end of Honshu Island, where most of its territory is mountainous. Populaton control is strongly expected by farmers and administration. However, the number of hunters has been drastically decreasing since the 1970’s. To maintain and increase hunters, we must investigate their activities and attitudes to clarify the problems. Questionnaires were conducted in 2001 on 310 hunters who renewed their hunting license at local office. The response rate was 80.0%. Wild boar hunters accounted for 61.6%, and the others were mostly bird hunters (32.5%. The objective of wild boar hunting was predominantly nuisance control, and very few hunted for money despite of its high commercial value. Most of them were farmers (35.8% and/or farm village dwellers (53.6%, and used the leg snare (61.4%. Despite the stable number of hunters, the number of hunters using guns is decreasing. Hunters do not to appear to be interested in maintaining the local hunting society. Leisure is the most pursued objective rather nuisance control. Therefore, actions should be taken to stimulate hunting as a leisure activity thus maintaining an important tool for wild boar management.

  11. 78 FR 77113 - Bakken Hunter, LLC; Notice of Application

    Science.gov (United States)

    2013-12-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Bakken Hunter, LLC; Notice of Application Take notice that on December 2, 2013 Bakken Hunter, LLC (Bakken), 410 17th Street, Denver, Colorado 80202, filed in Docket No....

  12. Why do good hunters have higher reproductive success?

    Science.gov (United States)

    Smith, Eric Alden

    2004-12-01

    Anecdotal evidence from many hunter-gatherer societies suggests that successful hunters experience higher prestige and greater reproductive success. Detailed quantitative data on these patterns are now available for five widely dispersed cases (Ache, Hadza, !Kung, Lamalera, and Meriam) and indicate that better hunters exhibit higher age-corrected reproductive success than other men in their social group. Leading explanations to account for this pattern are: (1) direct provisioning of hunters' wives and offspring, (2) dyadic reciprocity, (3) indirect reciprocity, (4) costly signaling, and (5) phenotypic correlation. I examine the qualitative and quantitative evidence bearing on these explanations and conclude that although none can be definitively rejected, extensive and apparently unconditional sharing of large game somewhat weakens the first three explanations. The costly signaling explanation has support in some cases, although the exact nature of the benefits gained from mating or allying with or deferring to better hunters needs further study.

  13. Urban metabolism in Syracuse, NY – introduction

    Science.gov (United States)

    David J. Nowak

    2016-01-01

    This special issue of Urban Ecosystems contains a series of papers related to assessing urban metabolism in Syracuse, NY. These papers were developed under the Urban Long-Term Research Area Exploratory Awards Program funded by the National Science Foundation. Objectives of this two-year project (2009–2011) in Syracuse, NY were to investigate: a)...

  14. Urine antibody against human cancer antigen NY-ESO-1

    OpenAIRE

    Jäger, Dirk; Stockert, Elisabeth; Karbach, Julia; Herrlinger, Kristina; Atmaca, Akin; Arand, Michael; Chen, Yao-Tseng; Gnjatic, Sacha; Old, Lloyd J.; Knuth, Alexander; Jäger, Elke

    2002-01-01

    NY-ESO-1 is one of the most immunogenic tumor antigens known to date. Spontaneous humoral and cellular immune responses against NY-ESO-1 are detected in a substantial proportion of patients with NY-ESO-1 positive cancers. NY-ESO-1 serum antibody is dependent on the presence of NY-ESO-1+ cancer cells, and antibody titers correlate with the clinical development of the disease. NY-ESO-1 serum antibody is associated with detectable NY-ESO-1-specific CD8+ T cell reactivity. High titers of NY-ESO-1...

  15. 76 FR 46149 - Financial Assistance: Wildlife Restoration, Sport Fish Restoration, Hunter Education and Safety

    Science.gov (United States)

    2011-08-01

    ... Assistance: Wildlife Restoration, Sport Fish Restoration, Hunter Education and Safety; Final Rule #0;#0... Restoration, Hunter Education and Safety AGENCY: Fish and Wildlife Service, Interior. ACTION: Final rule... Restoration, Sport Fish Restoration, and Hunter Education and Safety (Enhanced Hunter Education and...

  16. Channel centerline for Hunter Creek, Oregon in 1940

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Hunter Creek is an unregulated system that drains 115 square kilometers of southwestern Oregon before flowing into the Pacific Ocean south of the town of Gold...

  17. The Hunter Drain Stillwater National Wildlife Refuge Fallon, Nevada

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document outlines water quality concerns related to the operation of the Hunter Drain located in the vicinity of the Stillwater National Wildlife Refuge. This...

  18. Channel centerline for Hunter Creek, Oregon in 2009

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Hunter Creek is an unregulated system that drains 115 square kilometers of southwestern Oregon before flowing into the Pacific Ocean south of the town of Gold Beach,...

  19. Channel centerline for Hunter Creek, Oregon in 2005

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Hunter Creek is an unregulated system that drains 115 square kilometers of southwestern Oregon before flowing into the Pacific Ocean south of the town of Gold Beach,...

  20. perceptions and adaptations of beekeepers and honey hunters to ...

    African Journals Online (AJOL)

    Prof. Adipala Ekwamu

    honey sector (i.e. honey hunters) to climate change are, however, not adequately explored. The objective ... resort, beekeepers that are severely affected by climate change had no other choice than abandoned beekeeping for .... Trees, shrub.

  1. Morality and Gender: A Commentary on Pratt, Golding, and Hunter.

    Science.gov (United States)

    Smetana, Judith G.

    1984-01-01

    Discusses problems in Pratt, Golding, and Hunter's investigation (in this issue) of two propositions central to Gilligan's (1982) thesis on the mismeasurement of women's moral orientation and development. Describes research addressing the problems and indicates directions for further research. (RH)

  2. Channel centerline for Hunter Creek, Oregon in 1965

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Hunter Creek is an unregulated system that drains 115 square kilometers of southwestern Oregon before flowing into the Pacific Ocean south of the town of Gold Beach,...

  3. Aerial photo mosaic of Hunter Creek, Oregon in 1940

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Hunter Creek is an unregulated system that drains 115 square kilometers of southwestern Oregon before flowing into the Pacific Ocean south of the town of Gold Beach,...

  4. Aerial photo mosaic of Hunter Creek, Oregon in 1965

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Hunter Creek is an unregulated system that drains 115 square kilometers of southwestern Oregon before flowing into the Pacific Ocean south of the town of Gold Beach,...

  5. [A case of tularemia in a Danish hunter].

    Science.gov (United States)

    Edfors, Robert; Smith, Birgitte; Lillebaek, Troels

    2010-02-01

    "Rabbit fever" (Francisella Tularensis) is a rare infection in Denmark. It was first described in Denmark in 1987. It is most likely to affect people who come into close contact with infected animals or ticks, such as hunters, butchers and veterinarians. The diagnosis should be suspected in such persons presenting with fever, headache, lethargy, lymphadenitis and bite wounds. We present a Danish case describing the diagnosis and treatment of a hunter infected with T. tularensis.

  6. Hunter perceptions and acceptance of alternative deer management regulations

    Science.gov (United States)

    Cornicelli, L.; Fulton, D.C.; Grund, M.D.; Fieberg, J.

    2011-01-01

    Wildlife managers are often confronted with a policy paradox where a majority of the public supports an outcome, but there is no agreement on specific management strategies to achieve this outcome. Previous research has also reported a link between regulatory acceptance, hunter satisfaction, and hunter participation rates. Thus, human dimensions research aimed at understanding hunter motivations and behavior is needed for effective management. In 2005, we surveyed Minnesota (USA) deer hunters (n = 6,000; 59% response) to evaluate attitudes regarding alternative deer (Odocoileus virginianus) harvest regulations. We also conducted a series of forced choice experiments in which respondents were asked to select an option from a list of representative regulations that might be adopted to achieve a particular deer management goal. Specifically, we modeled 5 deer population scenarios ranging from low populations with high buck-harvest rates to populations 50% over goal density. Our results indicate that hunters preferred different regulations depending on the population scenario, but generally preferred antler-point restrictions and disliked limiting buck licenses through a lottery. We also found consistency among scenarios, in that a small percentage of respondents indicated they would not hunt if regulations were changed. The results from this study should help wildlife managers design deer harvest regulations that are both acceptable to hunters and achieve management objectives. ?? 2011 The Wildlife Society.

  7. 'Impact hunters' catalyse cooperative hunting in two wild chimpanzee communities.

    Science.gov (United States)

    Gilby, Ian C; Machanda, Zarin P; Mjungu, Deus C; Rosen, Jeremiah; Muller, Martin N; Pusey, Anne E; Wrangham, Richard W

    2015-12-05

    Even when hunting in groups is mutually beneficial, it is unclear how communal hunts are initiated. If it is costly to be the only hunter, individuals should be reluctant to hunt unless others already are. We used 70 years of data from three communities to examine how male chimpanzees 'solve' this apparent collective action problem. The 'impact hunter' hypothesis proposes that group hunts are sometimes catalysed by certain individuals that hunt more readily than others. In two communities (Kasekela and Kanyawara), we identified a total of five males that exhibited high hunt participation rates for their age, and whose presence at an encounter with red colobus monkeys increased group hunting probability. Critically, these impact hunters were observed to hunt first more often than expected by chance. We argue that by hunting first, these males dilute prey defences and create opportunities for previously reluctant participants. This by-product mutualism can explain variation in group hunting rates within and between social groups. Hunting rates declined after the death of impact hunter FG in Kasekela and after impact hunter MS stopped hunting frequently in Kanyawara. There were no impact hunters in the third, smaller community (Mitumba), where, unlike the others, hunting probability increased with the number of females present at an encounter with prey.

  8. A Storm-by-Storm Analysis of Alpine and Regional Precipitation Dynamics at the Mount Hunter Ice Core Site, Denali National Park, Central Alaska Range

    Science.gov (United States)

    Saylor, P. L.; Osterberg, E. C.; Kreutz, K. J.; Wake, C. P.; Winski, D.

    2014-12-01

    In May-June 2013, an NSF-funded team from Dartmouth College and the Universities of Maine and New Hampshire collected two 1000-year ice cores to bedrock from the summit plateau of Mount Hunter in Denali National Park, Alaska (62.940291, -151.087616, 3912 m). The snow accumulation record from these ice cores will provide key insight into late Holocene precipitation variability in central Alaska, and compliment existing precipitation paleorecords from the Mt. Logan and Eclipse ice cores in coastal SE Alaska. However, correct interpretation of the Mt. Hunter accumulation record requires an understanding of the relationships between regional meteorological events and micrometeorological conditions at the Mt. Hunter ice core collection site. Here we analyze a three-month window of snow accumulation and meteorological conditions recorded by an Automatic Weather Station (AWS) at the Mt. Hunter site during the summer of 2013. Snow accumulation events are identified in the Mt. Hunter AWS dataset, and compared on a storm-by-storm basis to AWS data collected from the adjacent Kahiltna glacier 2000 m lower in elevation, and to regional National Weather Service (NWS) station data. We also evaluate the synoptic conditions associated with each Mt. Hunter accumulation event using NWS surface maps, NCEP-NCAR Reanalysis data, and the NOAA HYSPLIT back trajectory model. We categorize each Mt. Hunter accumulation event as pure snow accumulation, drifting, or blowing snow events based on snow accumulation, wind speed and temperature data using the method of Knuth et al (2009). We analyze the frequency and duration of events within each accumulation regime, in addition to the overall contribution of each event to the snowpack. Preliminary findings indicate that a majority of Mt. Hunter accumulation events are of pure accumulation nature (55.5%) whereas drifting (28.6%) and blowing (15.4%) snow events play a secondary role. Our results will characterize the local accumulation dynamics on

  9. Improvements to the Hunter Dose tracking system

    Energy Technology Data Exchange (ETDEWEB)

    Whiteside, T. S. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Aucott, T. J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Brand, A. D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Diprete, D. P. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-07-01

    Since 1965, the Savannah River Site (SRS) has conducted deer hunts which are open to the general public. SRS performs field monitoring for cesium-137 (Cs-137) of each harvested animal to determine whether the animal may be released to the hunter. A new field system for measuring Cs-137 in the harvested animals has been developed. The system incorporates numerous enhancements compared to the original system. The original system was composed of two Ludlum Measurements scalar-driven 2 inch x 2 inch sodium iodide counters, while the new system is based on a single Ametek Ortec Digibase-driven 2 inch x 4 inch x 16 inch sodium iodide gamma spectrometer. The new system includes a series of easy-to-assemble stainless steel encapsulated lead shields. The combination of the larger detector size and lead shielding improved the detection limit of the new system by a factor of approximately three compared to the original system. This lower detection limit allows for a larger number of measurements to be directly compared to the laboratory results, in cases where animal portions have been sampled. The results from developing and using this system are presented as well as recommendations on improvements to the overall field monitoring of the SRS hunts.

  10. Patricia Knapp’s Landmark Project to Develop a Plan of Curriculum-Integrated Library Instruction. A review of: Knapp, P. B. (1966. The Monteith College library experiment. New York, NY: Scarecrow Press.

    Directory of Open Access Journals (Sweden)

    Carol D. Howe

    2011-03-01

    Full Text Available Objective – To create a college-level, four-year plan of library instruction in which assignments directly relate to students’ course work. To develop tools to assess the plan’s effectiveness in improving students’ library skills and contributing to their overall academic success.Design – Exploratory longitudinal cohort study employing pilot library assignments, interviews, and questionnaires.Setting – Monteith College, one of eleven colleges at Wayne State University. Monteith was a small liberal arts college established in 1959 which stressed innovative teaching methods such as team-teaching, small-group discussion, and independent study (Worrell, 2002.Subjects – Teaching faculty from all three college divisions—social sciences, natural sciences, and humanities—and students at Monteith College. Over the course of the study the college employed between 15 and 30 faculty members and enrolled 300 to 700 students.Methods – The project team consisted of project director Patricia Knapp, a project librarian, and a project research analyst. The team worked with the teaching faculty to develop course-related library assignments. Students completed a series of assignments over several semesters as part of their course requirements. The assignment series changed over the course of the project. Students who entered in the fall of 1959 or the spring of 1960 completed Sequence A consisting of six assignments. Students who entered in the fall of 1960 completed Sequence B, six assignments that were a mixture of original and revised assignments. Students who entered in the spring or fall of 1961 completed two revised library assignments.In the summer of 1961, the investigators conducted the first of two small studies. They interviewed a random sample of 21 Monteith students about their experiences with the library and the required library assignments. The students also completed library performance tests such as choosing a subject heading

  11. On a periodic two-component Hunter-Saxton equation

    CERN Document Server

    Kohlmann, Martin

    2011-01-01

    We determine the solution of the geodesic equation associated with a periodic two-component Hunter-Saxton system on a semidirect product obtained from the diffeomorphism group of the circle, modulo rigid rotations, and a space of scalar functions. In particular, we compute the time of breakdown of the geodesic flow. As a further goal, we establish a local well-posedness result for the two-component Hunter-Saxton system in the smooth category. The paper gets in line with some recent results for the generalized Hunter-Saxton equation provided by Escher, Wu and Wunsch in [J. Escher, Preprint 2010] and [H. Wu, M. Wunsch, arXiv:1009.1688v1 [math.AP

  12. Multikulturalisme er en ny slags Apartheid

    DEFF Research Database (Denmark)

    Dyrberg, Torben Bech

    2016-01-01

    I en ny antologi retter forfatterne et kritisk lys mod forsvarerne af multikulturalisme. Og det er der god grund til, mener en af bogens redaktører. For den store gruppe, der hylder multikulturen, glemmer i al dens godhed, at de samtidig er med til at undergrave demokratiet og styrke uheldige mag...

  13. Multikulturalisme er en ny slags Apartheid

    DEFF Research Database (Denmark)

    Dyrberg, Torben Bech

    2016-01-01

    I en ny antologi retter forfatterne et kritisk lys mod forsvarerne af multikulturalisme. Og det er der god grund til, mener en af bogens redaktører. For den store gruppe, der hylder multikulturen, glemmer i al dens godhed, at de samtidig er med til at undergrave demokratiet og styrke uheldige mag...

  14. Mangfoldighed som ny EU-politik

    DEFF Research Database (Denmark)

    Thomsen, Steen

    2014-01-01

    Analyse. EU er stadig i krise. EU er endnu ikke kommet med i det globale opsving efter finanskrisen, og Sydeuropas strukturproblemer er uløste, men maskeret af statsstøtte via ECB. Vælgerne gav EU-politikerne en alvorlig advarsel ved valget til Europa-Parlamentet. Efter en bølge af ny regulering er...

  15. 2008 FEMA Lidar: South Oneida County (NY)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — For Oneida County, NY, there were two types of elevation datasets. The first type is LiDAR and the second one is Auto-correlation DEM. Auto-correlation DEM data was...

  16. Hunter-gatherer plant use in southwest Asia

    DEFF Research Database (Denmark)

    Otaegui, Amaia Arranz; Ibañez, Juan José; Zapata, Lydia

    2016-01-01

    This paper focuses on plant use by the last hunter-gatherers in the Levant, from the Last Glacial Maximum (LGM) to the first experiments with plant cultivation at the beginning of the Holocene. This review of Epipaleolithic and Early Neolithic plant use summarises available archaeobotanical and t...

  17. Planet Hunters 2 in the K2 Era

    Science.gov (United States)

    Schwamb, Megan E.; Fischer, Debra; Boyajian, Tabetha S.; Giguere, Matthew J.; Ishikawa, Sascha; Lintott, Chris; Lynn, Stuart; Schmitt, Joseph; Snyder, Chris; Wang, Ji; Barclay, Thomas

    2015-01-01

    Planet Hunters (http://www.planethunters.org) is an online citizen science project enlisting hundreds of thousands of people to search for planet transits in the publicly released Kepler data. Volunteers mark the locations of visible transits in a web interface, with multiple independent classifiers reviewing a randomly selected ~30-day light curve segment. In September 2014, Planet Hunters entered a new phase. The project was relaunched with a brand new online classification interface and discussion tool built using the Zooniverse's (http://www.zooniverse.org) latest technology and web platform. The website has been optimized for the rapid discovery and identification of planet candidates in the light curves from K2, the two-wheeled ecliptic plane Kepler mission. We will give an overview of the new Planet Hunters classification interface and Round 2 review system in context of the K2 data. We will present the first results from the Planet Hunters 2 search of K2 Campaigns 0 and 1 including a summary of new planet candidates.

  18. Planet Hunters: Assessing the Kepler Inventory of Short Period Planets

    CERN Document Server

    Schwamb, Megan E; Fischer, Debra A; Giguere, Matthew J; Lynn, Stuart; Smith, Arfon M; Brewer, John M; Parrish, Michael; Schawinski, Kevin; Simpson, Robert J

    2012-01-01

    We present the results from a search of data from the first 33.5 days of the Kepler science mission (Quarter 1) for exoplanet transits by the Planet Hunters citizen science project. Planet Hunters enlists members of the general public to visually identify transits in the publicly released Kepler light curves via the World Wide Web. Over 24,000 volunteers reviewed the Kepler Quarter 1 data set. We examine the abundance of \\geq 2 R\\oplus planets on short period (< 15 days) orbits based on Planet Hunters detections. We present these results along with an analysis of the detection efficiency of human classifiers to identify planetary transits including a comparison to the Kepler inventory of planet candidates. Although performance drops rapidly for smaller radii, \\geq 4 R\\oplus Planet Hunters \\geq 85% efficient at identifying transit signals for planets with periods less than 15 days for the Kepler sample of target stars. Our high efficiency rate for simulated transits along with recovery of the majority of Ke...

  19. Honey, Hadza, hunter-gatherers, and human evolution.

    Science.gov (United States)

    Marlowe, Frank W; Berbesque, J Colette; Wood, Brian; Crittenden, Alyssa; Porter, Claire; Mabulla, Audax

    2014-06-01

    Honey is the most energy dense food in nature. It is therefore not surprising that, where it exists, honey is an important food for almost all hunter-gatherers. Here we describe and analyze widespread honey collecting among foragers and show that where it is absent, in arctic and subarctic habitats, honey bees are also rare to absent. Second, we focus on one hunter-gatherer society, the Hadza of Tanzania. Hadza men and women both rank honey as their favorite food. Hadza acquire seven types of honey. Hadza women usually acquire honey that is close to the ground while men often climb tall baobab trees to raid the largest bee hives with stinging bees. Honey accounts for a substantial proportion of the kilocalories in the Hadza diet, especially that of Hadza men. Cross-cultural forager data reveal that in most hunter-gatherers, men acquire more honey than women but often, as with the Hadza, women do acquire some. Virtually all warm-climate foragers consume honey. Our closest living relatives, the great apes, take honey when they can. We suggest that honey has been part of the diet of our ancestors dating back to at least the earliest hominins. The earliest hominins, however, would have surely been less capable of acquiring as much honey as more recent, fully modern human hunter-gatherers. We discuss reasons for thinking our early ancestors would have acquired less honey than foragers ethnographically described, yet still significantly more than our great ape relatives.

  20. Medicinal and ethnoveterinary remedies of hunters in Trinidad

    OpenAIRE

    Georges Karla; Harper Tisha; Lans Cheryl; Bridgewater Elmo

    2001-01-01

    Abstract Background Ethnomedicines are used by hunters for themselves and their hunting dogs in Trinidad. Plants are used for snakebites, scorpion stings, for injuries and mange of dogs and to facilitate hunting success. Results Plants used include Piper hispidum, Pithecelobium unguis-cati, Bauhinia excisa, Bauhinia cumanensis, Cecropia peltata, Aframomum melegueta, Aristolochia rugosa, Aristolochia trilobata, Jatropha curcas, Jatropha gossypifolia, Nicotiana tabacum, Vernonia scorpioides, Pe...

  1. Sources of nonresponse to the Federal Waterfowl Hunter Questionnaire Survey

    Science.gov (United States)

    Barker, R.J.; Geissler, P.H.; Hoover, B.A.

    1992-01-01

    Response rates to the Federal Waterfowl Hunter Questionnaire Survey (WHQS) have declined since the 1950's, suggesting that harvest estimates may be biased. Consequently, we investigated reasons for WHQS nonresponse using surveys of waterfowl hunters in Arkansas, California, Louisiana, Minnesota, New Jersey, and Texas [USA]. Sampling frames were constructed using lists of buyers of state hunting licenses or state duck stamps. We mailed questionnaires to 16,452 randomly selected hunters, with 2 follow-up mailings at 3-week intervals. Questionnaires were completed by 8,812 respondents, and a further 587 interviews were conducted by telephone. Post offices accounted for between 53.7% (Minn.) and 92.8% (N.J.) of federal waterfowl duck stamp sales, and stores accounted for most other sales. Of hunters who bought a federal waterfowl stamp from sample post offices, between 16.7% (Minn.) and 40.0% (Ark.) reported receiving a WHQS contact card. Of those receiving contact cards, between 30.0% (N.J.) and 64.3% (La. and Tex.) reported returning them. Because survey coverage of the target population is poor, we recommend that a new sampling frame be developed for the WHQS.

  2. Hot subduction: Magmatism along the Hunter Ridge, SW Pacific

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, A.J.; Verbeeten, A.; Danyushevsky, L.V.; Sigurdsson, I.A. [SRC for Ore Deposit Research, Hobart, TAS (Australia); Maillet, P. [Australian National University, Canberra, ACT (Australia). Department of Geology; Maillet, P. [ORSTOM Centre de Brest, France, (France); Monzier, M. [ORSTOM Centre, Ecuador, (Ecuador)

    1997-12-31

    The Hunter `fracture zone` is generally regarded as a transform plate boundary linking the oppositely dipping Tongan and Vanuatu subduction systems. Dredging along the Hunter Ridge and sampling of its northernmost extent, exposed as the island of Kadavu in Fiji, has yielded a diversity of magmatic suites, including arc tholeiites and high-Ca boninites, high-Mg lavas with some affinities to boninites and some affinities to adakites, and true adakitic lavas associated with remarkable low-Fe, high-Na basalts with 8-16 ppm Nb (herein high-Nb basalts). Lavas which show clear evidence of slab melt involvement in their petrogenesis occur at either end of the Hunter Ridge, whereas the arc tholeiites and high-Ca boninites appear to be restricted to the south central part of the ridge. Mineralogical and whole rock geochemical data for each of these suites are summarized, and a tectono-magmatic model for their genesis and distribution is suggested. Trace element features and radiogenic isotope data for the Hunter Ridge lavas indicate compositions analogue to Pacific MORB-like mantle. Extended abstract. 6 refs., 2 figs.

  3. The Enchanted Hunters in Nabokov’s Lolita

    National Research Council Canada - National Science Library

    Justine Shu- Ting Kao

    2017-01-01

    In Nabokov’s Lolita, Humbert Humbert’s The Enchanted Hunters, as a quest for love, aims to reconstruct a felicitous world or integrate various fragmentary details into an organic unity that revives a lost love, experiencing it on the...

  4. Camp stability predicts patterns of hunter-gatherer cooperation.

    Science.gov (United States)

    Smith, Daniel; Dyble, Mark; Thompson, James; Major, Katie; Page, Abigail E; Chaudhary, Nikhil; Salali, Gul Deniz; Vinicius, Lucio; Migliano, Andrea Bamberg; Mace, Ruth

    2016-07-01

    Humans regularly cooperate with non-kin, which has been theorized to require reciprocity between repeatedly interacting and trusting individuals. However, the role of repeated interactions has not previously been demonstrated in explaining real-world patterns of hunter-gatherer cooperation. Here we explore cooperation among the Agta, a population of Filipino hunter-gatherers, using data from both actual resource transfers and two experimental games across multiple camps. Patterns of cooperation vary greatly between camps and depend on socio-ecological context. Stable camps (with fewer changes in membership over time) were associated with greater reciprocal sharing, indicating that an increased likelihood of future interactions facilitates reciprocity. This is the first study reporting an association between reciprocal cooperation and hunter-gatherer band stability. Under conditions of low camp stability individuals still acquire resources from others, but do so via demand sharing (taking from others), rather than based on reciprocal considerations. Hunter-gatherer cooperation may either be characterized as reciprocity or demand sharing depending on socio-ecological conditions.

  5. Librarians as Hunter-Gatherers: Lessons Learned from an Excursion

    Science.gov (United States)

    Cooper, Mindy M.

    2013-01-01

    Fueled by the pressing need for electronic resource usage statistics, librarians are finding themselves being thrust into the role of hunter-gatherer. This article discusses the work done at University Library at Indiana University-Purdue University Indianapolis to provide usage statistics for all its paid subscriptions for a 3-year period. The…

  6. Hunter syndrome: Case report and review of literature

    African Journals Online (AJOL)

    There are about thirteen different clinical syndromes of. MPS.2 We report a case of Hunter syndrome, as far as we know this is the .... egaly and cardiovascular complications after the transplant in children. ' .... Bone marrow trans- plantation in ...

  7. A bivalent scale for measuring crowding among deer hunters

    Science.gov (United States)

    Gigliotti, Larry M.; Chase, Loren

    2014-01-01

    One factor that may influence satisfaction in outdoor recreation is crowding, which historically has been defined as a negative evaluation of the density of other participants. While this definition is suitable for most scenarios, there are circumstances where encounters with others in the area are evaluated positively and thus contribute to the satisfaction of the participant. To adequately describe this phenomenon we suggest a more inclusive measurement of crowding that allows for both positive and negative evaluations of participant density to more accurately explore the relationship between crowding and satisfaction. We identified a sub-group of deer hunters who negatively evaluated the low density of other hunters, which reduced their satisfaction with their overall hunting experience. The methodology for measuring crowding in recreation research may have an important effect in identifying the relationship crowding has with other relevant variables as well as management implications.

  8. HiggsHunters - a citizen science project for ATLAS

    CERN Document Server

    Haas, Andrew; The ATLAS collaboration

    2017-01-01

    Since the launch of HiggsHunters.org in November 2014, citizen science volunteers have classified more than a million points of interest in images from the ATLAS experiment at the LHC. Volunteers have been looking for displaced vertices and unusual features in images recorded during LHC Run-1. We discuss the design of the project, its impact on the public, and the surprising results of how the human volunteers performed relative to the computer algorithms in identifying displaced secondary vertices.

  9. Sacrificing Steve: How I Killed the Crocodile Hunter

    Directory of Open Access Journals (Sweden)

    Luke Carman

    2010-09-01

    Full Text Available Bob Hodge and Vijay Mishra argue that the complex issues of illegitimacy at the core of Australian identity are repressed through a continual process of cyclical silencing, where traces of a shameful past are exorcised by a focus on images of a mythologised ‘legend’, embodied in characters such as 'The Man from Snowy River'. This article explores such a 'schizophrenic' cycle in relation to the life, death and resurrection of Steve 'Crocodile Hunter' Irwin.

  10. HiggsHunters - a citizen science project for ATLAS

    CERN Document Server

    Haas, Andrew; The ATLAS collaboration

    2016-01-01

    Since the launch of HiggsHunters.org in November 2014, citizen science volunteers have classified more than a million points of interest in images from the ATLAS experiment at the LHC. Volunteers have been looking for displaced vertices and unusual features in images recorded during LHC Run-1. We discuss the design of the project, its impact on the public, and the surprising results of how the human volunteers performed relative to the computer algorithms in identifying displaced secondary vertices.

  11. Sacrificing Steve : how I killed the Crocodile Hunter

    Directory of Open Access Journals (Sweden)

    Carman, Luke

    2010-01-01

    Full Text Available Bob Hodge and Vijay Mishra argue that the complex issues of illegitimacy at the core of Australian identity are repressed through a continual process of cyclical silencing, where traces of a shameful past are exorcised by a focus on images of a mythologised ‘legend’, embodied in characters such as 'The Man from Snowy River'. This article explores such a 'schizophrenic' cycle in relation to the life, death and resurrection of Steve 'Crocodile Hunter' Irwin.

  12. Hunter Fleming与Access合作开发oligotropin

    Institute of Scientific and Technical Information of China (English)

    陆义(摘)

    2005-01-01

    英国Hunter Fleming公司已与美国的药物输送公司Access Pharmaceuticals签署合作协议,采用Access公司的维生素B12口服药物输送技术,开发治疗亨廷顿氏阿尔茨海默氏病的口服制剂oligotropin(HF0420)。

  13. Hunter-Gatherers and the Origins of Religion.

    Science.gov (United States)

    Peoples, Hervey C; Duda, Pavel; Marlowe, Frank W

    2016-09-01

    Recent studies of the evolution of religion have revealed the cognitive underpinnings of belief in supernatural agents, the role of ritual in promoting cooperation, and the contribution of morally punishing high gods to the growth and stabilization of human society. The universality of religion across human society points to a deep evolutionary past. However, specific traits of nascent religiosity, and the sequence in which they emerged, have remained unknown. Here we reconstruct the evolution of religious beliefs and behaviors in early modern humans using a global sample of hunter-gatherers and seven traits describing hunter-gatherer religiosity: animism, belief in an afterlife, shamanism, ancestor worship, high gods, and worship of ancestors or high gods who are active in human affairs. We reconstruct ancestral character states using a time-calibrated supertree based on published phylogenetic trees and linguistic classification and then test for correlated evolution between the characters and for the direction of cultural change. Results indicate that the oldest trait of religion, present in the most recent common ancestor of present-day hunter-gatherers, was animism, in agreement with long-standing beliefs about the fundamental role of this trait. Belief in an afterlife emerged, followed by shamanism and ancestor worship. Ancestor spirits or high gods who are active in human affairs were absent in early humans, suggesting a deep history for the egalitarian nature of hunter-gatherer societies. There is a significant positive relationship between most characters investigated, but the trait "high gods" stands apart, suggesting that belief in a single creator deity can emerge in a society regardless of other aspects of its religion.

  14. Evolutionary history of hunter-gatherer marriage practices.

    Directory of Open Access Journals (Sweden)

    Robert S Walker

    Full Text Available BACKGROUND: The universality of marriage in human societies around the world suggests a deep evolutionary history of institutionalized pair-bonding that stems back at least to early modern humans. However, marriage practices vary considerably from culture to culture, ranging from strict prescriptions and arranged marriages in some societies to mostly unregulated courtship in others, presence to absence of brideservice and brideprice, and polyandrous to polygynous unions. The ancestral state of early human marriage is not well known given the lack of conclusive archaeological evidence. METHODOLOGY: Comparative phylogenetic analyses using data from contemporary hunter-gatherers around the world may allow for the reconstruction of ancestral human cultural traits. We attempt to reconstruct ancestral marriage practices using hunter-gatherer phylogenies based on mitochondrial DNA sequences. RESULTS: Arranged marriages are inferred to go back at least to first modern human migrations out of Africa. Reconstructions are equivocal on whether or not earlier human marriages were arranged because several African hunter-gatherers have courtship marriages. Phylogenetic reconstructions suggest that marriages in early ancestral human societies probably had low levels of polygyny (low reproductive skew and reciprocal exchanges between the families of marital partners (i.e., brideservice or brideprice. DISCUSSION: Phylogenetic results suggest a deep history of regulated exchange of mates and resources among lineages that enhanced the complexity of human meta-group social structure with coalitions and alliances spanning across multiple residential communities.

  15. PhosphoHunter: An Efficient Software Tool for Phosphopeptide Identification

    Directory of Open Access Journals (Sweden)

    Alessandra Tiengo

    2015-01-01

    Full Text Available Phosphorylation is a protein posttranslational modification. It is responsible of the activation/inactivation of disease-related pathways, thanks to its role of “molecular switch.” The study of phosphorylated proteins becomes a key point for the proteomic analyses focused on the identification of diagnostic/therapeutic targets. Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS is the most widely used analytical approach. Although unmodified peptides are automatically identified by consolidated algorithms, phosphopeptides still require automated tools to avoid time-consuming manual interpretation. To improve phosphopeptide identification efficiency, a novel procedure was developed and implemented in a Perl/C tool called PhosphoHunter, here proposed and evaluated. It includes a preliminary heuristic step for filtering out the MS/MS spectra produced by nonphosphorylated peptides before sequence identification. A method to assess the statistical significance of identified phosphopeptides was also formulated. PhosphoHunter performance was tested on a dataset of 1500 MS/MS spectra and it was compared with two other tools: Mascot and Inspect. Comparisons demonstrated that a strong point of PhosphoHunter is sensitivity, suggesting that it is able to identify real phosphopeptides with superior performance. Performance indexes depend on a single parameter (intensity threshold that users can tune according to the study aim. All the three tools localized >90% of phosphosites.

  16. Does lateral transmission obscure inheritance in hunter-gatherer languages?

    Science.gov (United States)

    Bowern, Claire; Epps, Patience; Gray, Russell; Hill, Jane; Hunley, Keith; McConvell, Patrick; Zentz, Jason

    2011-01-01

    In recent years, linguists have begun to increasingly rely on quantitative phylogenetic approaches to examine language evolution. Some linguists have questioned the suitability of phylogenetic approaches on the grounds that linguistic evolution is largely reticulate due to extensive lateral transmission, or borrowing, among languages. The problem may be particularly pronounced in hunter-gatherer languages, where the conventional wisdom among many linguists is that lexical borrowing rates are so high that tree building approaches cannot provide meaningful insights into evolutionary processes. However, this claim has never been systematically evaluated, in large part because suitable data were unavailable. In addition, little is known about the subsistence, demographic, ecological, and social factors that might mediate variation in rates of borrowing among languages. Here, we evaluate these claims with a large sample of hunter-gatherer languages from three regions around the world. In this study, a list of 204 basic vocabulary items was collected for 122 hunter-gatherer and small-scale cultivator languages from three ecologically diverse case study areas: northern Australia, northwest Amazonia, and California and the Great Basin. Words were rigorously coded for etymological (inheritance) status, and loan rates were calculated. Loan rate variability was examined with respect to language area, subsistence mode, and population size, density, and mobility; these results were then compared to the sample of 41 primarily agriculturalist languages. Though loan levels varied both within and among regions, they were generally low in all regions (mean 5.06%, median 2.49%, and SD 7.56), despite substantial demographic, ecological, and social variation. Amazonian levels were uniformly very low, with no language exhibiting more than 4%. Rates were low but more variable in the other two study regions, in part because of several outlier languages where rates of borrowing were

  17. Does lateral transmission obscure inheritance in hunter-gatherer languages?

    Directory of Open Access Journals (Sweden)

    Claire Bowern

    Full Text Available In recent years, linguists have begun to increasingly rely on quantitative phylogenetic approaches to examine language evolution. Some linguists have questioned the suitability of phylogenetic approaches on the grounds that linguistic evolution is largely reticulate due to extensive lateral transmission, or borrowing, among languages. The problem may be particularly pronounced in hunter-gatherer languages, where the conventional wisdom among many linguists is that lexical borrowing rates are so high that tree building approaches cannot provide meaningful insights into evolutionary processes. However, this claim has never been systematically evaluated, in large part because suitable data were unavailable. In addition, little is known about the subsistence, demographic, ecological, and social factors that might mediate variation in rates of borrowing among languages. Here, we evaluate these claims with a large sample of hunter-gatherer languages from three regions around the world. In this study, a list of 204 basic vocabulary items was collected for 122 hunter-gatherer and small-scale cultivator languages from three ecologically diverse case study areas: northern Australia, northwest Amazonia, and California and the Great Basin. Words were rigorously coded for etymological (inheritance status, and loan rates were calculated. Loan rate variability was examined with respect to language area, subsistence mode, and population size, density, and mobility; these results were then compared to the sample of 41 primarily agriculturalist languages. Though loan levels varied both within and among regions, they were generally low in all regions (mean 5.06%, median 2.49%, and SD 7.56, despite substantial demographic, ecological, and social variation. Amazonian levels were uniformly very low, with no language exhibiting more than 4%. Rates were low but more variable in the other two study regions, in part because of several outlier languages where rates of

  18. The Enchanted Hunters in Nabokov’s Lolita

    Directory of Open Access Journals (Sweden)

    Justine Shu- Ting Kao

    2017-06-01

    Full Text Available In Nabokov’s Lolita, Humbert Humbert’s The Enchanted Hunters, as a quest for love, aims to reconstruct a felicitous world or integrate various fragmentary details into an organic unity that revives a lost love, experiencing it on the basis of irony, and revealing a simulation of the desire, violence, and despondency which have been expressed in myths of nymphs and Persephone. The protagonist never reaches this unity, but his narrative of erotic and romantic love reveals him as a pathetic addict engaged in mechanical reproduction related to the phenomena of desire, seduction, violence, and sex. His The Enchanted Hunters does not simulate what he expects of his childhood love with Annabel; rather, it simulates the erotic imagination suggested in Mary D. Sheriff’s term “nymphomania,” in which artists fall degenerately to a model of tragedy. Keywords: simulation, nymph, nymphomania, The Enchanted Hunters The Enchanted Hunters in Nabokov’s Lolita refers to the name of a hotel and the title of a play. This seeming coincidence is actually not coincidental: Nabokov weaves a story concerning a pedophile’s seduction of a prepubescent child into a “story within a story,” in which the girl is imagined as a seducer who bewitches a number of hunters. Just as the girl in the play is a figment of a poet’s imagination, so Lolita in the novel Lolita is an imaginary production of a middle-aged pedophile. Yet Lolita is not so much a novel revealing guilt and mental disorder, but a mélange of art and reality, or more specifically, it is about a coinage in which the author fabricates art and myth in real life. Parallel to the protagonist who simulates what he expects of his childhood love, Annabel, in the form of the nymphet, Lolita, Nabokov replicates the beauty of butterflies in the pursuit of beauty and immortality, and develops the world of art with a pathetic tone whereby we gradually perceive a simulation of the desire, violence, and

  19. Planet Hunters, Undergraduate Research, and Detection of Extrasolar Planet Kepler-818 b

    Science.gov (United States)

    Baker, David; Crannell, Graham; Duncan, James; Hays, Aryn; Hendrix, Landon

    2017-01-01

    Detection of extrasolar planets provides an excellent research opportunity for undergraduate students. In Spring 2012, we searched for transiting extrasolar planets using Kepler spacecraft data in our Research Experience in Physics course at Austin College. Offered during the regular academic year, these Research Experience courses engage students in the scientific process, including proposal writing, paper submission, peer review, and oral presentations. Since 2004, over 190 undergraduate students have conducted authentic scientific research through Research Experience courses at Austin College.Zooniverse’s citizen science Planet Hunters web site offered an efficient method for rapid analysis of Kepler data. Light curves from over 5000 stars were analyzed, of which 2.3% showed planetary candidates already tagged by the Kepler team. Another 1.5% of the light curves suggested eclipsing binary stars, and 1.6% of the light curves had simulated planets for training purposes.One of the stars with possible planetary transits had not yet been listed as a planetary candidate. We reported possible transits for Kepler ID 4282872, which later was promoted to planetary candidate KOI-1325 in 2012 and confirmed to host extrasolar planet Kepler-818 b in 2016 (Morton et al. 2016). Kepler-818 b is a “hot Neptune” with period 10.04 days, flux decrease during transit ~0.4%, planetary radius 4.69 Earth radii, and semi-major axis 0.089 au.

  20. The ecological and evolutionary energetics of hunter-gatherer residential mobility

    CERN Document Server

    Hamilton, Marcus J; Rupley, Eric; Youn, Hyejin; West, Geoffrey B

    2016-01-01

    Residential mobility is deeply entangled with all aspects of hunter-gatherer life ways, and is therefore an issue of central importance in hunter-gatherer studies. Hunter-gatherers vary widely in annual rates of residential mobility, and understanding the sources of this variation has long been of interest to anthropologists and archaeologists. Since mobility is, to a large extent, driven by the need for a continuous supply of food, a natural framework for addressing this question is provided by the metabolic theory of ecology. This provides a powerful framework for formulating formal testable hypotheses concerning evolutionary and ecological constraints on the scale and variation of hunter-gatherer residential mobility. We evaluate these predictions using extant data and show strong support for the hypotheses. We show that the overall scale of hunter-gatherer residential mobility is predicted by average human body size, and the limited capacity of mobile hunter-gatherers to store energy internally. We then s...

  1. Mot en ny pedagogisk lederrolle og lederidentitet?

    Directory of Open Access Journals (Sweden)

    Ann Kristin Larsen

    2014-02-01

    Full Text Available Artikkelen omhandler hvordan endrede ledelsesstrukturer oppstått gjennom ny organisasjonsmodell virker inn på de pedagogiske ledernes arbeidsoppgaver. Vi har etterspurt deres erfaringer knyttet til mulige endringer i oppgaver, arbeidsdeling og faglig-pedagogisk fokus i arbeidet. Undersøkelsen ble gjennomført i en bydel i Oslo. Hovedfunnene er at pedagogiske ledere har fått flere administrative oppgaver og personalleder oppgaver. De pedagogiske lederne deler seg i to med hensyn til hvor fornøyde de er med disse endringene. I artikkelen drøfter vi hva denne todelingen betyr for deres rolleforståelse og identitet.

  2. 33 CFR 80.160 - Montauk Point, NY to Atlantic Beach, NY.

    Science.gov (United States)

    2010-07-01

    ... Light 322° true across the southwest tangent of the island on the north side of Jones Inlet to the... to Atlantic Beach, NY. (a) A line drawn from the Shinnecock Inlet East Breakwater Light to Shinnecock Inlet West Breakwater Light 1. (b) A line drawn from Moriches Inlet East Breakwater Light to...

  3. Faget almen dannelse og ny teknologi

    DEFF Research Database (Denmark)

    Tiemensma, Britt Due

    2015-01-01

    16 lektioner anvendes Skoletube, en digital platform rettet mod folkeskolen samt gratis programmer, som jeg forestiller mig vil imødekomme de studerendes behov for sjove oplevelser og samtidig ruste dem til at forholde sig reflekteret og nuanceret til etiske, politiske, demokratiske og religiøse......Denne case handler om, hvordan 90 lærerstuderende på 1. årg. introduceres til faget almen dannelse ud fra en antagelse om, at ny teknologi påvirker forestillingen om, hvad der er relevant viden for professionsudøvelsen, og således også hvad der skal prioriteres i studiet. I introduktionsforløbet på...... udfordringer i relation til skole- og forældresamarbejde. Udfordringen er altså at få ny teknologi til at indgå som aktør i faget almen dannelse og skabe en eksemplarisk praksis, hvor de studerende kan udvikle sig fagligt og personligt i forhold til kommende undervisningsopgaver i folkeskolen....

  4. The Hunter pulmonary angiography catheter for a brachiocephalic vein approach.

    Science.gov (United States)

    Rosen, Galia; Kowalik, Karen J; Ganguli, Suverano; Hunter, David W

    2006-01-01

    The purpose of this work was to describe our experience in performing pulmonary angiography using the Hunter pulmonary catheter, manufactured by Cook, Inc., which is a modified 6F pigtail catheter with a "C-shaped" curve, designed for a brachiocephalic vein approach. One hundred twenty-three patients underwent pulmonary angiograms using the Hunter catheter between August 1997 and January 2002. Operator comments were gathered in 86 (70%) of the cases. The operator was, if possible, the most junior resident on the service. Thirty-nine operators participated in the survey. Efficacy, safety, and ease of use of the catheter were determined by operators' comments and ECG observations during the procedure. Corroborating clinical data were gathered from medical records. In 68 (79%) of the procedures that were commented upon, the operator described insertion into the pulmonary artery (PA) as easy; only 2 (2%) indicated difficulty in accessing the PA. In 41 (63%) of the bilateral angiograms that were commented upon, the operator described accessing the left PA from the right PA as easy; only 6 (9%) rated it as difficult and all were with an older technique in which the catheter was withdrawn to the pulmonary bifurcation without a wire or with only the soft tip of the wire in the pigtail and then rotated to the left main pulmonary artery. Thirty-one of the 41 patients who demonstrated premature ventricular contractions (PVCs) had a previous history of heart disease. Nineteen of the 39 patients who did not have PVCs had a history of heart disease (p = 0.018). The maneuverability and shape of the Hunter catheter make pulmonary angiography an easy procedure, even for operators with minimal experience and limited technical proficiency. PVCs demonstrated a statistically significant correlation with a positive patient history for cardiac disease, rather than being a universal risk.

  5. The Fugue Pattern in The Heart is a Lonely Hunter

    Institute of Scientific and Technical Information of China (English)

    郭主美

    2013-01-01

    Carson McCullers The Heart is a Lonely Hunter is her representative work. McCullers deploys the skill of fugue pattern through the multi-voices reflected in the characters, tactfully unite the form and content into a whole. By adopting Bakhtin ’s theory of polyphony, this paper aims to analyze the fugue pattern together with its multi-voices in the three parts, namely, the exposition, the development and the return reflected in the novel, which highlights its theme of universal loneliness so impressive-ly.

  6. 33 CFR 110.208 - Buffalo Harbor, N.Y.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Buffalo Harbor, N.Y. 110.208 Section 110.208 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.208 Buffalo Harbor, N.Y. (a) The anchorage...

  7. 33 CFR 110.84b - Buffalo, N.Y.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Buffalo, N.Y. 110.84b Section 110.84b Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.84b Buffalo, N.Y. The area within the Port of Buffalo known as...

  8. NY-ESO-1 specific antibody and cellular responses in melanoma patients primed with NY-ESO-1 protein in ISCOMATRIX and boosted with recombinant NY-ESO-1 fowlpox virus.

    Science.gov (United States)

    Chen, Ji-Li; Dawoodji, Amina; Tarlton, Andrea; Gnjatic, Sacha; Tajar, Abdelouahid; Karydis, Ioannis; Browning, Judy; Pratap, Sarah; Verfaille, Christian; Venhaus, Ralph R; Pan, Linda; Altman, Douglas G; Cebon, Jonathan S; Old, Lloyd L; Nathan, Paul; Ottensmeier, Christian; Middleton, Mark; Cerundolo, Vincenzo

    2015-03-15

    Vaccination strategies based on repeated injections of NY-ESO-1 protein formulated in ISCOMATRIX particles (NY-ESO-1 ISCOMATRIX) have shown to elicit combined NY-ESO-1 specific antibody and T cell responses. However, it remains unclear whether heterologous prime-boost strategies based on the combination with NY-ESO-1 ISCOMATRIX with different NY-ESO-1 boosting reagents could be used to increase NY-ESO-1 CD8(+) or CD4(+) T cell responses. To address this question, we carried out a randomized clinical trial in 39 high-risk, resected melanoma patients vaccinated with NY-ESO-1 ISCOMATRIX, and then boosted with repeated injections of either recombinant fowlpox virus encoding full length NY-ESO-1 (rF-NY-ESO-1) (Arm A) or NY-ESO-1 ISCOMATRIX alone (Arm B). We have comprehensively analyzed NY-ESO-1 specific T cells and B cells response in all patients before and after vaccination for a total of seven time points per patient. NY-ESO-1 ISCOMATRIX alone elicited a strong NY-ESO-1 specific CD4(+) T cell and antibody response, which was maintained by both regiments at similar levels. However, CD8(+) T cell responses were significantly boosted in 3 out of 18 patients in Arm A after the first rF-NY-ESO-1 injection and such responses were maintained until the end of the trial, while no patients in Arm B showed similar CD8(+) T cell responses. In addition, our results clearly identified immunodominant regions in the NY-ESO-1 protein: NY-ESO-179-102 and NY-ESO-1115-138 for CD4+ T cells and NY-ESO-185-108 for CD8+ T cells in a large proportion of vaccinated patients. These regions of NY-ESO-1 protein should be considered in future clinical trials as immunodominant epitopes. © 2014 UICC.

  9. Solar Energy Development Assistance for Fort Hunter Liggett

    Energy Technology Data Exchange (ETDEWEB)

    Russo, Bryan J.; Hoffman, Michael G.; Chvala, William D.

    2011-03-30

    Pacific Northwest National Laboratory provided assistance to Fort Hunter Liggett to determine the opportunities for solar energy development on the site. Increasing use of renewable energy is mandated by several executive orders and legislation. Fort Hunter Liggett has many attributes that enhance its suitability for renewable energy development. First, the site is located south of San Francisco in a remote portion of the costal foothills. Brush and forest fires are frequent and often result in power outages, which subsequently impacts the site’s training mission. In addition, the site’s blended electric rate during fiscal year (FY) 2010 was high at 12 ¢/kWh. Lastly, the solar resource is moderately high; the site receives nearly 5.7 kWh/m2/day on a south facing, latitude-tilted surface. In light of these factors, the site is a clear candidate for a solar photovoltaic array. Prior to Pacific Northwest National Laboratory’s (PNNL) involvement, the site secured funding for a 1 megawatt (MW) photovoltaic (PV) array that will also provide shading for site vehicles. To best implement this project, PNNL conducted a site visit and was tasked with providing the site technical guidance and support regarding module selection, array siting, and other ancillary issues.

  10. Medicinal and ethnoveterinary remedies of hunters in Trinidad

    Directory of Open Access Journals (Sweden)

    Georges Karla

    2001-11-01

    Full Text Available Abstract Background Ethnomedicines are used by hunters for themselves and their hunting dogs in Trinidad. Plants are used for snakebites, scorpion stings, for injuries and mange of dogs and to facilitate hunting success. Results Plants used include Piper hispidum, Pithecelobium unguis-cati, Bauhinia excisa, Bauhinia cumanensis, Cecropia peltata, Aframomum melegueta, Aristolochia rugosa, Aristolochia trilobata, Jatropha curcas, Jatropha gossypifolia, Nicotiana tabacum, Vernonia scorpioides, Petiveria alliacea, Renealmia alpinia, Justicia secunda, Phyllanthus urinaria,Phyllanthus niruri,Momordica charantia, Xiphidium caeruleum, Ottonia ovata, Lepianthes peltata, Capsicum frutescens, Costus scaber, Dendropanax arboreus, Siparuma guianensis, Syngonium podophyllum, Monstera dubia, Solanum species, Eclipta prostrata, Spiranthes acaulis, Croton gossypifolius, Barleria lupulina, Cola nitida, Acrocomia ierensis (tentative ID. Conclusion Plant use is based on odour, and plant morphological characteristics and is embedded in a complex cultural context based on indigenous Amerindian beliefs. It is suggested that the medicinal plants exerted a physiological action on the hunter or his dog. Some of the plants mentioned contain chemicals that may explain the ethnomedicinal and ethnoveterinary use. For instance some of the plants influence the immune system or are effective against internal and external parasites. Plant baths may contribute to the health and well being of the hunting dogs.

  11. Metagenome Sequencing of the Hadza Hunter-Gatherer Gut Microbiota.

    Science.gov (United States)

    Rampelli, Simone; Schnorr, Stephanie L; Consolandi, Clarissa; Turroni, Silvia; Severgnini, Marco; Peano, Clelia; Brigidi, Patrizia; Crittenden, Alyssa N; Henry, Amanda G; Candela, Marco

    2015-06-29

    Through human microbiome sequencing, we can better understand how host evolutionary and ontogenetic history is reflected in the microbial function. However, there has been no information on the gut metagenome configuration in hunter-gatherer populations, posing a gap in our knowledge of gut microbiota (GM)-host mutualism arising from a lifestyle that describes over 90% of human evolutionary history. Here, we present the first metagenomic analysis of GM from Hadza hunter-gatherers of Tanzania, showing a unique enrichment in metabolic pathways that aligns with the dietary and environmental factors characteristic of their foraging lifestyle. We found that the Hadza GM is adapted for broad-spectrum carbohydrate metabolism, reflecting the complex polysaccharides in their diet. Furthermore, the Hadza GM is equipped for branched-chain amino acid degradation and aromatic amino acid biosynthesis. Resistome functionality demonstrates the existence of antibiotic resistance genes in a population with little antibiotic exposure, indicating the ubiquitous presence of environmentally derived resistances. Our results demonstrate how the functional specificity of the GM correlates with certain environment and lifestyle factors and how complexity from the exogenous environment can be balanced by endogenous homeostasis. The Hadza gut metagenome structure allows us to appreciate the co-adaptive functional role of the GM in complementing the human physiology, providing a better understanding of the versatility of human life and subsistence. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Medicinal and ethnoveterinary remedies of hunters in Trinidad.

    Science.gov (United States)

    Lans, C; Harper, T; Georges, K; Bridgewater, E

    2001-01-01

    Ethnomedicines are used by hunters for themselves and their hunting dogs in Trinidad. Plants are used for snakebites, scorpion stings, for injuries and mange of dogs and to facilitate hunting success. Plants used include Piper hispidum, Pithecelobium unguis-cati, Bauhinia excisa, Bauhinia cumanensis, Cecropia peltata, Aframomum melegueta, Aristolochia rugosa, Aristolochia trilobata, Jatropha curcas, Jatropha gossypifolia, Nicotiana tabacum, Vernonia scorpioides, Petiveria alliacea, Renealmia alpinia, Justicia secunda, Phyllanthus urinaria,Phyllanthus niruri,Momordica charantia, Xiphidium caeruleum, Ottonia ovata, Lepianthes peltata, Capsicum frutescens, Costus scaber, Dendropanax arboreus, Siparuma guianensis, Syngonium podophyllum, Monstera dubia, Solanum species, Eclipta prostrata, Spiranthes acaulis, Croton gossypifolius, Barleria lupulina, Cola nitida, Acrocomia ierensis (tentative ID). Plant use is based on odour, and plant morphological characteristics and is embedded in a complex cultural context based on indigenous Amerindian beliefs. It is suggested that the medicinal plants exerted a physiological action on the hunter or his dog. Some of the plants mentioned contain chemicals that may explain the ethnomedicinal and ethnoveterinary use. For instance some of the plants influence the immune system or are effective against internal and external parasites. Plant baths may contribute to the health and well being of the hunting dogs.

  13. Modern day relevance of William Hunter's approach to teaching "The organ of hearing".

    Science.gov (United States)

    Roth, Helena; Smith, Robert A; Mackay, Sarah

    2013-07-01

    William Hunter, a pioneering teacher of Anatomy in the the eighteenth century, championed the use of dissected specimens as aids in the teaching of anatomy. Although Hunter promoted the Paris method of learning Anatomy, by student dissection, he also used prosected material as an adjunct to his lectures. We are fortunate that Hunter bequeathed his extensive collection of over 3,000 museum specimens to the University of Glasgow, many of which are housed in the Laboratory of Human Anatomy in the Thomson Building. Regions such as the temporal bone are frequently difficult for students, and indeed postgraduate trainees in ear nose and throat surgery, to visualize and understand. Hunter overcame this difficulty by producing elegant specimens highlighting the three-dimensional complexity of the area. The current vignette stresses the importance of Hunter in his contemporary setting, but also demonstrates the potential of his approach for current and future teaching programmes in this age of the Internet.

  14. Analysis of heat pumps installed in family housing at Hunter Army Air Field

    Energy Technology Data Exchange (ETDEWEB)

    Parker, S.A.

    1994-08-01

    The US Army Forces Command (FORSCOM) tasked Pacific Northwest Laboratory (PNL) in support of the US Department of Energy (DOE) Federal Energy Management Program (FEMP) to conduct a postconstruction evaluation of the air-source heat pumps installed in family housing at Hunter Army Air Field (AAF). The objective of this project was to investigate and resolve concerns about an increase in energy costs at Hunter AAF following the installation of heat pumps in November 1992. After completing several analyses and a field inspection of the heat pumps in family housing at Hunter AAF, the following conclusions were made: the installation of air-source heat pumps reduced the annual energy cost in family housing by $46,672 in 1993; the heat pump thermostat controls in Hunter AAF family housing appear to be incorrectly installed; and the Hunter AAF electric utility bill increased 10% during the first 6 months of 1993 compared to the first 6 months of 1992.

  15. Legitimization of regulatory norms: Waterfowl hunter acceptance of changing duck bag limits

    Science.gov (United States)

    Schroeder, Susan A.; Fulton, David C.; Lawrence, Jeffrey S.; Cordts, Steven D.

    2014-01-01

    Few studies have examined response to regulatory change over time, or addressed hunter attitudes about changes in hunting bag limits. This article explores Minnesota waterfowl hunters’ attitudes about duck bag limits, examining attitudes about two state duck bag limits that were initially more restrictive than the maximum set by the U.S. Fish and Wildlife Service (USFWS), but then increased to match federal limits. Results are from four mail surveys that examined attitudes about bag limits over time. Following two bag limit increases, a greater proportion of hunters rated the new bag limit “too high” and a smaller proportion rated it “too low.” Several years following the first bag limit increase, the proportion of hunters who indicated that the limit was “too high” had declined, suggesting hunter acceptance of the new regulation. Results suggest that waterfowl bag limits may represent legal norms that influence hunter attitudes and gain legitimacy over time.

  16. 75 FR 21663 - Maysteel, LLC Including On-Site Leased Workers From Staff One, Badger Tech, Boyd Hunter, Seek...

    Science.gov (United States)

    2010-04-26

    ... Tech, Boyd Hunter, Seek, QPS, and Service First, Menomonee Falls, WI; Amended Certification Regarding..., including on-site leased workers from Staff One, Badger Tech, Boyd Hunter, Seek, and QPS, Menomonee Falls... Maysteel, LLC, including on-site leased workers from Staff One, Badger Tech, Boyd Hunter, Seek, QPS,...

  17. Hunter standoff killer team (HSKT) ground and flight test results

    Science.gov (United States)

    Moreland, Balinda; Ennis, Mark; Yeates, Robert; Condon, Timothy

    2007-04-01

    Since the inception of powered flight, manned aerial vehicles have been a force multiplier on the battlefield. With the emergence of new technology, the structure of the military battlefield is changing. One such technology, the Unmanned Aerial Vehicle (UAV) has emerged as a valuable asset for today's war fighter. UAVs have traditionally been operated by ground control stations, yet minimum research has been targeted towards UAV connectivity. Airborne Manned Unmanned System Technology Baseline (AMUST-Baseline) was a concept that demonstrated the battlefield synergy gained by Manned and Unmanned Vehicle teaming. AMUST-Baseline allowed an Apache Longbow's (AH-64D) co-pilot gunner (CPG) to have Level IV control of a Hunter fixed wing UAV. Level IV control of a UAV includes payload control, flight control and direct data receipt. With the success of AMUST-Baseline, AATD, Lockheed Martin, Northrop Grumman, and the Boeing Company worked towards enhanced Manned and Unmanned connectivity through a technology investment agreement. This effort named Airborne Manned Unmanned System Technology Demonstration (AMUST-D) focused on the connectivity between two manned platforms, Apache Longbow (AH-64D) and Command and Control (C2) Blackhawk, and Hunter UAV. It allows robust communication from the UAV to each platform through the Tactical Common Data Link (TCDL). AMUST-D used decision aiding technology developed under the Rotorcraft Pilots Associate (RPA) Advanced Technology Demonstration (ATD) as to assist in control of the Hunter UAV, as well as assist the pilot in regularly performed duties. Through the use of decision aiding and UAV control, the pilot and commander were better informed of potential threats and targets, thus increasing his situational awareness. The potential benefits of improved situational awareness are increased pilot survivability, increased lethality, and increased operational effectiveness. Two products were developed under the AMUST-D program, the

  18. Food Sharing among Hadza Hunter-Gatherer Children.

    Science.gov (United States)

    Crittenden, Alyssa N; Zes, David A

    2015-01-01

    Human prosociality is one of the defining characteristics of our species, yet the ontogeny of altruistic behavior remains poorly understood. The evolution of widespread food sharing in humans helped shape cooperation, family formation, life history, language, and the development of economies of scale. While the behavioral and ecological correlates of food sharing among adults are widely studied, very little is known about food sharing among children. Here, in the first study to analyze the food sharing patterns of hunter-gatherer children, we show that while sharing may be biased towards kin, reciprocity characterizes the majority of all sharing dyads, both related and unrelated. These data lend support to the recent claim that discrimination among kin might be linked with reciprocal altruism theory. Furthermore, we show that age positively correlates with an increase in sharing, both in frequency and amount, supporting recent suggestions that prosocial behaviors and egalitarianism develop strongly in middle childhood when children acquire the normative rules of their society.

  19. Visual Analysis of Biological Activity Data with Scaffold Hunter.

    Science.gov (United States)

    Klein, Karsten; Koch, Oliver; Kriege, Nils; Mutzel, Petra; Schäfer, Till

    2013-12-01

    The growing interest in chemogenomics approaches over the last years has led to an increasing amount of data regarding chemical and the corresponding biological activity space. The resulting data, collected in either in-house or public databases, need to be analyzed efficiently to speed-up the increasingly difficult task of drug discovery. Unfortunately, the discovery of new chemical entities or new targets for known drugs ('drug repurposing') is not suitable to a fully automated analysis or a simple drill down process. Visual interactive interfaces that allow to explore chemical space in a systematic manner and facilitate analytical reasoning can help to overcome these problems. Scaffold Hunter is a tool for the visual analysis of chemical compound databases that provides integrated visualization and analysis of biological activity data and fosters the interactive exploration of data imported from a variety of sources. We describe the features and illustrate the use by means of an exemplary analysis workflow.

  20. Costs and benefits in hunter-gatherer punishment.

    Science.gov (United States)

    Boehm, Christopher

    2012-02-01

    Hunter-gatherer punishment involves costs and benefits to individuals and groups, but the costs do not necessarily fit with the assumptions made in models that consider punishment to be altruistic--which brings in the free-rider problem and the problem of second-order free-riders. In this commentary, I present foragers' capital punishment patterns ethnographically, in the interest of establishing whether such punishment is likely to be costly; and I suggest that in many cases abstentions from punishment that might be taken as defections by free-riders are actually caused by social-structural considerations rather than being an effect of free-rider genes. This presentation of data supplements the ethnographic analysis provided by Guala.

  1. Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers

    OpenAIRE

    Jäger, Elke; Gnjatic, Sacha; Nagata, Yasuhiro; Stockert, Elisabeth; Jäger, Dirk; Karbach, Julia; Neumann, Antje; Rieckenberg, Julia; Chen, Yao-Tseng; Ritter, Gerd; Hoffman, Eric; Arand, Michael; Old, Lloyd J.; Knuth, Alexander

    2000-01-01

    Cancer–testis antigen NY-ESO-1 is one of the most immunogenic tumor antigens defined to date. Spontaneous humoral and CD8+ T-cell responses to NY-ESO-1 are detected in 40–50% of patients with advanced NY-ESO-1-expressing tumors. A clinical trial was initiated to study the immunological effects of intradermal vaccination with 3 HLA-A2-binding NY-ESO-1 peptides in 12 patients with metastatic NY-ESO-1-expressing cancers. Seven patients were NY-ESO-1 serum antibody neg...

  2. Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers

    OpenAIRE

    2000-01-01

    Cancer–testis antigen NY-ESO-1 is one of the most immunogenic tumor antigens defined to date. Spontaneous humoral and CD8+ T-cell responses to NY-ESO-1 are detected in 40–50% of patients with advanced NY-ESO-1-expressing tumors. A clinical trial was initiated to study the immunological effects of intradermal vaccination with 3 HLA-A2-binding NY-ESO-1 peptides in 12 patients with metastatic NY-ESO-1-expressing cancers. Seven patients were NY-ESO-1 serum antibody neg...

  3. The Bayesian image retrieval system, PicHunter: theory, implementation, and psychophysical experiments.

    Science.gov (United States)

    Cox, I J; Miller, M L; Minka, T P; Papathomas, T V; Yianilos, P N

    2000-01-01

    This paper presents the theory, design principles, implementation and performance results of PicHunter, a prototype content-based image retrieval (CBIR) system. In addition, this document presents the rationale, design and results of psychophysical experiments that were conducted to address some key issues that arose during PicHunter's development. The PicHunter project makes four primary contributions to research on CBIR. First, PicHunter represents a simple instance of a general Bayesian framework which we describe for using relevance feedback to direct a search. With an explicit model of what users would do, given the target image they want, PicHunter uses Bayes's rule to predict the target they want, given their actions. This is done via a probability distribution over possible image targets, rather than by refining a query. Second, an entropy-minimizing display algorithm is described that attempts to maximize the information obtained from a user at each iteration of the search. Third, PicHunter makes use of hidden annotation rather than a possibly inaccurate/inconsistent annotation structure that the user must learn and make queries in. Finally, PicHunter introduces two experimental paradigms to quantitatively evaluate the performance of the system, and psychophysical experiments are presented that support the theoretical claims.

  4. Influence of Age and Educational Level on the Behavior of Hunters in Vojvodina Province (Serbia

    Directory of Open Access Journals (Sweden)

    Vladimir Marković

    2011-07-01

    Full Text Available Education as an important factor in the development of economy has a major impact on the development of hunting and hunting tourism. In this research, it has conducted a survey of hunters from the territory of Vojvodina Province regarding their attitude and motives for hunting, importance of education, importance of GIS in hunting, poaching as well as their level of hunting ethics. Using SPSS program, it was cross-referenced the individual responses in relation to age category and level of education. The results show that the youngest hunters (18 to 35 years compared to middle age hunters (35-59 years and old hunters (over 60 visit hunting events more, they are the most informed about GIS and they are most willing to learn about these technologies. The number of hunters that took part in the poaching is proportional with their level of education, so that most hunters that participate in poaching hold a university degree. However, hunters holding a university degree in the highest percentage believe that GIS can contribute to the development of hunting largely, and are willing to participate in training.

  5. EnviroAtlas - New York, NY - Block Groups

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset is the base layer for the New York, NY EnviroAtlas community. The block groups are from the US Census Bureau and are included/excluded based...

  6. 77 FR 16800 - Radio Broadcasting Services; Westfield, NY

    Science.gov (United States)

    2012-03-22

    ... From the Federal Register Online via the Government Publishing Office ] FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Westfield, NY AGENCY: Federal Communications..., Radio broadcasting. Federal Communications Commission. Nazifa Sawez, Assistant Chief, Audio...

  7. Orthopedic manifestations in patients with muco­polysaccharidosis type II (Hunter syndrome enrolled in the Hunter Outcome Survey

    Directory of Open Access Journals (Sweden)

    Bianca Link

    2010-07-01

    Full Text Available Mucopolysaccharidosis type II (MPS II or Hunter syndrome is a rare, inherited disorder caused by deficiency of the lysosomal enzyme iduronate-2-sulfatase. As a result of this deficiency, glycosaminoglycans accumulate in lysosomes in many tissues, leading to progressive multisystemic disease. The cardiopulmonary and neurological problems associated with MPS II have received considerable attention. Orthopedic manifestations are common but not as well characterized. This study aimed to characterize the prevalence and severity of orthopedic manifestations of MPS II and to determine the relationship of these signs and symptoms with cardiovascular, pulmonary and central nervous system involvement. Orthopedic manifestations of MPS II were studied using cross-sectional data from the Hunter Outcome Survey (HOS. The HOS is a global, physician-led, multicenter observational database that collects information on the natural history of MPS II and the long-term safety and effectiveness of enzyme replacement therapy. As of January 2009, the HOS contained baseline data on joint range of motion in 124 males with MPS II. In total, 79% of patients had skeletal manifestations (median onset, 3.5 years and 25% had abnormal gait (median onset, 5.4 years. Joint range of motion was restricted for all joints assessed (elbow, shoulder, hip, knee and ankle. Extension was the most severely affected movement: the exception to this was the shoulder. Surgery for orthopedic problems was rare. The presence of orthopedic manifestations was associated with the presence of central nervous system and pulmonary involvement, but not so clearly with cardiovascular involvement. Orthopedic interventions should be considered on an individual-patient basis. Although some orthopedic manifestations associated with MPS II may be managed routinely, a good knowledge of other concurrent organ system involvement is essential. A multidisciplinary approach is required.

  8. Middle Holocene Unconformity in Seneca Lake, NY

    Science.gov (United States)

    Curtin, T. M.; Crocker, M.; Loddengaard, K.

    2008-12-01

    The post-glacial history of the Finger Lakes, NY have involved several changes in lake levels throughout the latest Pleistocene and Holocene, resulting from the changing position of the retreating Laurentide ice sheet, river outlet position, glacial rebound, and water balance. Previous studies of high-resolution seismic reflection profiles from three Finger Lakes define a middle Holocene erosional surface at water depths as great as 26 m in the northern end of each of lake. There are two proposed hypotheses to explain the origin of the observed erosional surfaces: 1) subaerial erosion during a lake lowstand and 2) erosion resulting from increased internal seiche activity. To evaluate these hypotheses, we examined a series of 2 to 5 m long piston cores collected along a north-south transect from one of the Finger Lakes, Seneca Lake. Cores were correlated using distinctive changes in the profiles of grain size, loss-on-ignition, and magnetic susceptibility. We recognize a significant erosional unconformity of early to middle Holocene sediment at modern depths 60 m, the unconformity continues as a conformable zone. We attribute the unconformity to wave abrasion and nearshore current winnowing of the shoreface during a lowstand. With an assumption of an effective 20 m wave base, the depth to the low level lake surface responsible for the unconformity is estimated to be 40 m. The age of the unconformity is ~6 ka, based on radiocarbon ages of lithologic boundaries in the sediment cores. Because the unconformity grades into a conformable zone in deepwater cores that display no change in lithology, we hypothesize that the large-scale lake level drop is likely not the result of climate change, but rather a change in accommodation space in the northern portion of the lake basin due to glacial rebound.

  9. Autoimmune thyroid disease elicited by NY-ESO-1 vaccination.

    Science.gov (United States)

    Vita, Roberto; Guarneri, Fabrizio; Agah, Ravin; Benvenga, Salvatore

    2014-02-01

    Immunotherapies and targeted therapies are frequently associated with thyroid dysfunction, which is in contrast with the rare thyroid abnormalities induced by cytotoxic agents. Immunotherapy with NY-ESO-1, a tumor-associated antigen expressed by a number of malignancies, was reported to trigger hyperthyroidism or hypothyroidism in two HLA-A2 patients with ovarian cancer. We describe now a case of Graves' disease triggered by NY-ESO-1 in a HLA-A2-negative woman. A 32-year-old woman with a synovial sarcoma received radiotherapy, chemotherapy, and finally NY-ESO-1 vaccine. The patient was found to have HLA A11/A33(19), B13/B56(22), Cw3/-. One month after the beginning of immunotherapy, thyroid dysfunction was clinically suspected and Graves' disease was biochemically confirmed. Fearful of the antithyroid drugs' side effects, the patient was treated with a beta-blocker (propranolol, 80-20 mg/day). As hyperthyroidism progressively worsened, the patient underwent total thyroidectomy. We hypothesized that NY-ESO-1 shared partial homology with thyroid autoantigens (the so-called molecular mimicry mechanism) and that at least one pair of homologous sequences contained amino acid sequence binding motifs to a restricted number of HLA molecules. We used BLAST software to search amino acid sequence homologies between NY-ESO-1 and thyroid autoantigens (thyrotropin receptor [TSH-R], thyroperoxidase, and thyroglobulin), and the HLA ligand/motif database to look for HLA/T-cell receptor binding motifs in the regions of NY-ESO-1 and thyroid autoantigens that were homologous. We found 15 epitopic regions of NY-ESO-1 homologous to 15 regions of thyroid autoantigens, some of which epitopic: 5 of TSH-R, 8 of thyroglobulin, and 2 of thyroperoxidase. These homologous sequences contain binding motifs belonging to several HLA class I antigens, including HLA A2 and the patient's A11 and A33. Genetically predisposed patients who receive NY-ESO-1 vaccination are at risk to develop thyroid

  10. Symmetry Reduction and Group Invariant Solutions of Hunter-Saxton Equations%Hunter-Saxton方程的对称约化与群不变解

    Institute of Scientific and Technical Information of China (English)

    檀美英; 胡恒春

    2016-01-01

    借助符号计算软件Maple,根据微分方程单参数不变群和群不变解的概念,利用李群对称的待定系数法,得到Hunter-Saxton方程的包含5个任意常数和一个任意函数的一般形式的对称.通过该对称中任意的函数和常数的不同选取,将Hunter-Saxton方程约化为不同形式的常微分方程.最后对约化后的常微分方程进行变换求解,进一步得出Hunter-Saxton方程的一些群不变解和精确解.

  11. Assessing the Main-Belt Comet Population with Comet Hunters

    Science.gov (United States)

    Schwamb, Megan E.; Hsieh, Henry H.; Zhang, Zhi-Wei; Chen, Ying-Tung; Lintott, Chris; Wang, Shiang-Yu; Mishra, Ishan

    2017-01-01

    Cometary activity in the asteroid belt is a recent discovery. Evidence suggests recent collisions play a role excavating subsurface water ice in these Main Belt Comets (MBCs). MBCs may be an alternative source of Earth’s water. The properties and origins of the MBCs remain elusive. To date ~15 MBCs are known, but only with many tens to 100s of MBCs can we fully explore this new reservoir and its implications for the early Earth.Automated routines identify cometary objects by comparing the point spread functions (PSFs) of moving objects to background stars. This approach may miss cometary activity with low-level dust comae or trails that are too weak or extended to affect an object's near-nucleus PSF profile. Direct visual inspection of moving objects by survey team members can often catch such unusual objects, but such an approach is impractical for the largest surveys to date, and will only become more intractable with the next generation wide-field surveys.With the Internet, tens of thousands of people can be engaged in the scientific process. With this citizen science approach, the combined assessment of many non-experts often equals or rivals that of a trained expert and in many cases outperforms automated algorithms. The Comet Hunters (http://www.comethunters.org) project enlists the public to search for MBCs in data from the Hyper Suprime-Cam (HSC) wide survey. HSC is to date the largest field-of-view camera (covering a 1.5 degree diameter circle on sky) on a 8-10-m class telescope. The HSC wide survey provides the sensitivity to detect cometary activity at lower levels than have been possible for previous surveys.We will give an overview of the Comet Hunters project. We will present the results from the first ~10,000 HSC asteroids searched and provide an estimate on the frequency of cometary activity in the Main Asteroid beltAcknowledgements: This work uses data generated via the Zooniverse.org platform, development of which was supported by a Global

  12. Integrability and Solutions of the (2 + 1)-dimensional Hunter-Saxton Equation

    Science.gov (United States)

    Cai, Hong-Liu; Qu, Chang-Zheng

    2016-04-01

    In this paper, the (2 + 1)-dimensional Hunter-Saxton equation is proposed and studied. It is shown that the (2 + 1)-dimensional Hunter-Saxton equation can be transformed to the Calogero-Bogoyavlenskii-Schiff equation by reciprocal transformations. Based on the Lax-pair of the Calogero-Bogoyavlenskii-Schiff equation, a non-isospectral Lax-pair of the (2 + 1)-dimensional Hunter-Saxton equation is derived. In addition, exact singular solutions with a finite number of corners are obtained. Furthermore, the (2 + 1)-dimensional μ-Hunter-Saxton equation is presented, and its exact peaked traveling wave solutions are derived. Supported by National Natural Science Foundation of China under Grant No. 11471174 and NSF of Ningbo under Grant No. 2014A610018

  13. Wetted channel and bar features for Hunter Creek, Oregon in 1965

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Hunter Creek is an unregulated system that drains 115 square kilometers of southwestern Oregon before flowing into the Pacific Ocean south of the town of Gold Beach,...

  14. Wetted channel and bar features for Hunter Creek, Oregon in 2005

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Hunter Creek is an unregulated system that drains 115 square kilometers of southwestern Oregon before flowing into the Pacific Ocean south of the town of Gold Beach,...

  15. Hunter Harvest and Effort North Mississippi Refuges Complex 2001-2014

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Reports contains summarized yearly harvest of game species on Coldwater River, Dahomey, and Tallahatchie NWRs and the total hunter effort based on daily use cards...

  16. Wetted channel and bar features for Hunter Creek, Oregon in 1940

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Hunter Creek is an unregulated system that drains 115 square kilometers of southwestern Oregon before flowing into the Pacific Ocean south of the town of Gold Beach,...

  17. Wetted channel and bar features for Hunter Creek, Oregon in 2009

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Hunter Creek is an unregulated system that drains 115 square kilometers of southwestern Oregon before flowing into the Pacific Ocean south of the town of Gold Beach,...

  18. 弱耗散μ-Hunter-Saxton 方程的爆破%Blow-up of a weakly dissipative μ-Hunter-Saxton equation

    Institute of Scientific and Technical Information of China (English)

    吕红杰; 刘静静; 齐静; 刘硕

    2015-01-01

    研究了弱耗散μ-Hunter-Saxton 方程 Caucly 问题的爆破现象。给出了一个新的爆破结果,推导出爆破强解精确的爆破率。%We study the Cauchy problem of the weakly dissipative μ-Hunter-Saxton equation.The present work is main-ly concerned with blow-up phenomena of the equation.We first present a new blow-up result for strong solutions to the equation.Then,we drive the precise blow-up rate for strong solutions to the equation.

  19. Evaluating cost-efficiency and accuracy of hunter harvest survey designs

    Science.gov (United States)

    Lukacs, P.M.; Gude, J.A.; Russell, R.E.; Ackerman, B.B.

    2011-01-01

    Effective management of harvested wildlife often requires accurate estimates of the number of animals harvested annually by hunters. A variety of techniques exist to obtain harvest data, such as hunter surveys, check stations, mandatory reporting requirements, and voluntary reporting of harvest. Agencies responsible for managing harvested wildlife such as deer (Odocoileus spp.), elk (Cervus elaphus), and pronghorn (Antilocapra americana) are challenged with balancing the cost of data collection versus the value of the information obtained. We compared precision, bias, and relative cost of several common strategies, including hunter self-reporting and random sampling, for estimating hunter harvest using a realistic set of simulations. Self-reporting with a follow-up survey of hunters who did not report produces the best estimate of harvest in terms of precision and bias, but it is also, by far, the most expensive technique. Self-reporting with no followup survey risks very large bias in harvest estimates, and the cost increases with increased response rate. Probability-based sampling provides a substantial cost savings, though accuracy can be affected by nonresponse bias. We recommend stratified random sampling with a calibration estimator used to reweight the sample based on the proportions of hunters responding in each covariate category as the best option for balancing cost and accuracy. ?? 2011 The Wildlife Society.

  20. Portrait of a Geothermal Spring, Hunter's Hot Springs, Oregon.

    Science.gov (United States)

    Castenholz, Richard W

    2015-01-27

    Although alkaline Hunter's Hot Springs in southeastern Oregon has been studied extensively for over 40 years, most of these studies and the subsequent publications were before the advent of molecular methods. However, there are many field observations and laboratory experiments that reveal the major aspects of the phototrophic species composition within various physical and chemical gradients of these springs. Relatively constant temperature boundaries demark the upper boundary of the unicellular cyanobacterium, Synechococcus at 73-74 °C (the world-wide upper limit for photosynthesis), and 68-70 °C the upper limit for Chloroflexus. The upper limit for the cover of the filamentous cyanobacterium, Geitlerinema (Oscillatoria) is at 54-55 °C, and the in situ lower limit at 47-48 °C for all three of these phototrophs due to the upper temperature limit for the grazing ostracod, Thermopsis. The in situ upper limit for the cyanobacteria Pleurocapsa and Calothrix is at ~47-48 °C, which are more grazer-resistant and grazer dependent. All of these demarcations are easily visible in the field. In addition, there is a biosulfide production in some sections of the springs that have a large impact on the microbiology. Most of the temperature and chemical limits have been explained by field and laboratory experiments.

  1. Food Sharing among Hadza Hunter-Gatherer Children.

    Directory of Open Access Journals (Sweden)

    Alyssa N Crittenden

    Full Text Available Human prosociality is one of the defining characteristics of our species, yet the ontogeny of altruistic behavior remains poorly understood. The evolution of widespread food sharing in humans helped shape cooperation, family formation, life history, language, and the development of economies of scale. While the behavioral and ecological correlates of food sharing among adults are widely studied, very little is known about food sharing among children. Here, in the first study to analyze the food sharing patterns of hunter-gatherer children, we show that while sharing may be biased towards kin, reciprocity characterizes the majority of all sharing dyads, both related and unrelated. These data lend support to the recent claim that discrimination among kin might be linked with reciprocal altruism theory. Furthermore, we show that age positively correlates with an increase in sharing, both in frequency and amount, supporting recent suggestions that prosocial behaviors and egalitarianism develop strongly in middle childhood when children acquire the normative rules of their society.

  2. Genetic and cultural kinship among the Lamaleran whale hunters.

    Science.gov (United States)

    Alvard, Michael

    2011-07-01

    The human ability to form large, coordinated groups is among our most impressive social adaptations. Larger groups facilitate synergistic economies of scale for cooperative breeding, such economic tasks as group hunting, and success in conflict with other groups. In many organisms, genetic relationships provide the structure for sociality to evolve via the process of kin selection, and this is the case, to a certain extent, for humans. But assortment by genetic affiliation is not the only mechanism that can bring people together. Affinity based on symbolically mediated and socially constructed identity, or cultural kinship, structures much of human ultrasociality. This paper examines how genetic kinship and two kinds of cultural kinship--affinal kinship and descent--structure the network of cooperating whale hunters in the village of Lamalera, Indonesia. Social network analyses show that each mechanism of assortment produces characteristic networks of different sizes, each more or less conducive to the task of hunting whales. Assortment via close genetic kin relationships (r = 0.5) produces a smaller, denser network. Assortment via less-close kin relations (r = 0.125) produces a larger but less dense network. Affinal networks are small and diffuse; lineage networks are larger, discrete, and very dense. The roles that genetic and cultural kinship play for structuring human sociality is discussed in the context of these results.

  3. Adaptive memory: fitness relevance and the hunter-gatherer mind.

    Science.gov (United States)

    Nairne, James S; Pandeirada, Josefa N S; Gregory, Karie J; Van Arsdall, Joshua E

    2009-06-01

    Recent studies suggest that human memory systems are "tuned" to remember information that is processed in terms of its fitness value. When people are asked to rate the relevance of words to a survival scenario, performance on subsequent surprise memory tests exceeds that obtained after most other known encoding techniques. The present experiments explored this effect using survival scenarios designed to mimic the division of labor thought to characterize early hunter-gatherer societies. It has been suggested that males and females have different cognitive specializations due to the unique survival tasks (hunting and gathering, respectively) they typically performed during periods of human evolution; the present experiments tested whether such specializations might be apparent in memory for words rated for relevance to these activities. Males and females were asked to rate the relevance of random words to prototypical hunting and gathering scenarios or to matched, non-fitness-relevant control scenarios (gathering food on a scavenger hunt or in a hunting contest). Surprise retention tests revealed superior memory for the words when they were rated for relevance to hunting and gathering scenarios, compared with when they were rated for relevance to the control scenarios, but no sex differences were found in memory performance.

  4. Conservation laws and symmetries of Hunter-Saxton equation: revisited

    Science.gov (United States)

    Tian, Kai; Liu, Q. P.

    2016-03-01

    Through a reciprocal transformation {{T}0} induced by the conservation law {{\\partial}t}≤ft(ux2\\right)={{\\partial}x}≤ft(2uux2\\right) , the Hunter-Saxton (HS) equation {{u}xt}=2u{{u}2x}+ux2 is shown to possess conserved densities involving arbitrary smooth functions, which have their roots in infinitesimal symmetries of {{w}t}={{w}2} , the counterpart of the HS equation under {{T}0} . Hierarchies of commuting symmetries of the HS equation are studied under appropriate changes of variables initiated by {{T}0} , and two of these are linearized while the other is identical to the hierarchy of commuting symmetries admitted by the potential modified Korteweg-de Vries equation. A fifth order symmetry of the HS equation is endowed with a sixth order hereditary recursion operator, which is proved to have a bi-Hamiltonian factorization, by its connection with the Fordy-Gibbons equation. These results reveal the origin for the rich and remarkable structures of the HS equation and partially answer the questions raised by Wang (2010 Nonlinearity 23 2009).

  5. Rabbit hunter uveitis: case report of tularemia uveitis.

    Science.gov (United States)

    Terrada, Céline; Azza, Said; Bodaghi, Bahram; Le Hoang, Phuc; Drancourt, Michel

    2016-09-01

    Literature reports on ophthalmological manifestations related to tularemia, a zoonose caused by the bacterium Francisella tularensis, largely refer to Parinaud's oculoglandular syndrome, which consists of the association of conjunctivitis with preauricular lymphadenitis. In this paper, we report a case of intraocular inflammation during tularemia infection. A 52-year-old Caucasian man was diagnosed with unilateral uveitis. The uveitis was posterior, with a 2+ vitritis and a large yellowish lesion involving the macula with an overlying sub-retinal detachment, extending inferiorly, and subretinal hemorrhages. Fluorescein angiography showed a late hyperfluorescence with focal vascular leakage. Ultrasound biomicroscopy confirmed the presence of a 3.8 mm parietal granuloma with a few calcifications in the left eye. While extensive work-up eliminated any other infectious and non-infectious etiology, tularemia was diagnosed by advanced serology consisting of two-dimensional Western-immunoblotting. The patient, a hunter, recalled having killed rabbits in the days before the symptoms appeared. Uveitis was rapidly controlled following treatment with doxycycline, yet three years after initiation of the treatment, the patient still complained of loss of vision in the left eye with a central scotoma. Posterior uveitis may be an infrequent manifestation of tularemia infection, and therefore this infection should be considered in the differential diagnosis of intraocular inflammation in areas where F. tularensis is endemic.

  6. En ny generasjon troverdige kliniske retningslinjer

    Directory of Open Access Journals (Sweden)

    Per Olav Vandvik

    2013-11-01

    Full Text Available Trygg og effektiv diagnostikk, pleie og behandling fordrer at helsepersonell har tilgang til oppdatert og gyldig forskningsbasert kunnskap, fortrinnsvis i form av faglige kliniske retningslinjer utviklet med tilfredsstillende metodikk. De fleste retningslinjer har imidlertid betydelige svakheter med hensyn til både kunnskapsgrunnlag, utvikling av anbefalinger, presentasjonsformater og oppdatering. Nye definisjoner, standarder og metoder for kunnskapsbaserte troverdige retningslinjer gir langt bedre muligheter enn tidligere for å lykkes i arbeidet med å utvikle og implementere retningslinjer, men stiller samtidig større krav til metodekompetanse, klinisk ekspertise og tid. I vår digitale tidsalder åpner ny nettbasert teknologi for bedre disseminering av retningslinjer til frontlinjene i klinikken, og til å dele kunnskap med pasienter i konsultasjonen, for eksempel gjennom smarttelefoner og lesebrett. Gjennom et praktisk eksempel redegjør vi i denne artikkelen for nye definisjoner, standarder, metoder og verktøy for utvikling, disseminering og oppdatering av faglige retningslinjer. GRADE-systemet er en sentral komponent i dette. Det er nå mulig å lage troverdige retningslinjer som klinikere og pasienter kan ta i bruk i en travel hverdag. Det gjenstår å se hvordan myndighetene og fagmiljøene vil bidra for å sikre pasienter trygg og effektiv behandling gjennom utvikling av denne nye generasjonen av kliniske retningslinjer.Vandvik PO, Berg R, Vist G. A new generation of trustworthy clinical practice guidelines. Nor J Epidemiol 2013; 23 (2: 197-204.ENGLISH SUMMARYSafe and effective diagnosis and treatment requires that health care personnel can access the best current research evidence, preferably through clinical practice guidelines. Most guidelines suffer from methodological weaknesses (e.g., identification and assessment of research evidence, development of recommendations, suboptimal presentation formats and infrequent updating of

  7. ESPRESSO: the ultimate rocky exoplanets hunter for the VLT

    Science.gov (United States)

    Mégevand, Denis; Zerbi, Filippo M.; Cabral, Alexandre; Di Marcantonio, Paolo; Amate, Manuel; Pepe, Francesco; Cristiani, Stefano; Rebolo, Rafael; Santos, Nuno C.; Dekker, Hans; Abreu, Manuel; Affolter, Michael; Avila, Gerardo; Baldini, Veronica; Bristow, Paul; Broeg, Christopher; Carvas, Pedro; Cirami, Roberto; Coelho, João.; Comari, Maurizio; Conconi, Paolo; Coretti, Igor; Cupani, Guido; D'Odorico, Valentina; De Caprio, Vincenzo; Delabre, Bernard; Figueira, Pedro; Fleury, Michel; Fragoso, Ana; Genolet, Ludovic; Gomes, Ricardo; Gonzalez Hernandez, Jonay; Hughes, Ian; Iwert, Olaf; Kerber, Florian; Landoni, Marco; Lima, Jorge; Lizon, Jean-Louis; Lovis, Christophe; Maire, Charles; Mannetta, Marco; Martins, Carlos; Moitinho, André; Molaro, Paolo; Monteiro, Manuel; Rasilla, José Luis; Riva, Marco; Santana Tschudi, Samuel; Santin, Paolo; Sosnowska, Danuta; Sousa, Sergio; Spanò, Paolo; Tenegi, Fabio; Toso, Giorgio; Vanzella, Eros; Viel, Matteo; Zapatero Osorio, Maria Rosa

    2012-09-01

    ESPRESSO, the VLT rocky exoplanets hunter, will combine the efficiency of modern echelle spectrograph with extreme radial-velocity precision. It will be installed at Paranal on ESO's VLT in order to achieve a gain of two magnitudes with respect to its predecessor HARPS, and the instrumental radial-velocity precision will be improved to reach 10 cm/s level. We have constituted a Consortium of astronomical research institutes to fund, design and build ESPRESSO on behalf of and in collaboration with ESO, the European Southern Observatory. The project has passed the preliminary design review in November 2011. The spectrograph will be installed at the so-called "Combined Coudé Laboratory" of the VLT, it will be linked to the four 8.2 meters Unit Telescopes (UT) through four optical "Coudé trains" and will be operated either with a single telescope or with up to four UTs. In exchange of the major financial and human effort the building Consortium will be awarded with guaranteed observing time (GTO), which will be invested in a common scientific program. Thanks to its characteristics and the ability of combining incoherently the light of 4 large telescopes, ESPRESSO will offer new possibilities in many fields of astronomy. Our main scientific objectives are, however, the search and characterization of rocky exoplanets in the habitable zone of quiet, near-by G to M-dwarfs, and the analysis of the variability of fundamental physical constants. In this paper, we present the ambitious scientific objectives, the capabilities of ESPRESSO, the technical solutions for the system and its subsystems, enlightening the main differences between ESPRESSO and its predecessors. The project aspects of this facility are also described, from the consortium and partnership structure to the planning phases and milestones.

  8. Transsulfuration pathway thiols and methylated arginines: the Hunter Community Study.

    Directory of Open Access Journals (Sweden)

    Arduino A Mangoni

    Full Text Available BACKGROUND: Serum homocysteine, when studied singly, has been reported to be positively associated both with the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine [ADMA, via inhibition of dimethylarginine dimethylaminohydrolase (DDAH activity] and with symmetric dimethylarginine (SDMA. We investigated combined associations between transsulfuration pathway thiols, including homocysteine, and serum ADMA and SDMA concentrations at population level. METHODS: Data on clinical and demographic characteristics, medication exposure, C-reactive protein, serum ADMA and SDMA (LC-MS/MS, and thiols (homocysteine, cysteine, taurine, glutamylcysteine, total glutathione, and cysteinylglycine; capillary electrophoresis were collected from a sample of the Hunter Community Study on human ageing [n = 498, median age (IQR = 64 (60-70 years]. RESULTS: REGRESSION ANALYSIS SHOWED THAT: a age (P = 0.001, gender (P = 0.03, lower estimated glomerular filtration rate (eGFR, P = 0.08, body mass index (P = 0.008, treatment with beta-blockers (P = 0.03, homocysteine (P = 0.02, and glutamylcysteine (P = 0.003 were independently associated with higher ADMA concentrations; and b age (P = 0.001, absence of diabetes (P = 0.001, lower body mass index (P = 0.01, lower eGFR (P<0.001, cysteine (P = 0.007, and glutamylcysteine (P < 0.001 were independently associated with higher SDMA concentrations. No significant associations were observed between methylated arginines and either glutathione or taurine concentrations. CONCLUSIONS: After adjusting for clinical, demographic, biochemical, and pharmacological confounders the combined assessment of transsulfuration pathway thiols shows that glutamylcysteine has the strongest and positive independent associations with ADMA and SDMA. Whether this reflects a direct effect of glutamylcysteine on DDAH activity (for ADMA and/or cationic amino acid transport requires further investigations.

  9. The night of the hunter: children & adults in the secret

    Directory of Open Access Journals (Sweden)

    Terry caesar

    2010-04-01

    Full Text Available Night of the Hunter is  the 1956 Charles Laughton’s film considered  one of the best discussions about childhood. In this film, the story revolves around the fate of John and Pearl, two orphaned siblings whose father was hanged for stealing. The father had given the children the money, and they hid the money inside the girl’s doll. When the Preacher Powell enters their lives , both John and Pearl are in danger. The siblings have to keep a secret which is both where they put the money, and the fact that, for children, money is simply paper.

  10. The Effects of Changing Sea Ice on Marine Mammals and Their Hunters in Northern Alaska

    Science.gov (United States)

    Huntington, H.; Quakenbush, L.; Nelson, M.

    2015-12-01

    Marine mammals are important sources of food for indigenous residents of northern Alaska. Changing sea ice patterns affect the animals themselves as well as access by hunters. Documenting the traditional knowledge of Iñupiaq and Yupik hunters concerning marine mammals and sea ice makes accessible a wide range of information and insight relevant to ecological understanding, conservation action, and the regulation of human activity. We interviewed hunters in villages from northern Bering Sea to the Beaufort Sea, focusing on bowhead whales, walrus, and ice seals. Hunters reported extensive changes in sea ice, with resulting effects on the timing of marine mammal migrations, the distribution and behavior of the animals, and the efficacy of certain hunting methods, for example the difficulty of finding ice thick enough to support a bowhead whale for butchering. At the same time, hunters acknowledged impacts and potential impacts from changing technology such as more powerful outboard engines and from industrial activity such as shipping and oil and gas development. Hunters have been able to adapt to some changes, for example by hunting bowhead whales in fall as well as spring on St. Lawrence Island, or by focusing their hunt in a shorter period in Nuiqsut to accommodate work schedules and worse weather. Other changes, such as reduced availability of ice seals due to rapid retreat of pack ice after spring break-up, continue to defy easy responses. Continued environmental changes, increased disturbance from human activity, and the introduction of new regulations for hunting may further challenge the ability of hunters to provide food as they have done to date, though innovation and flexibility may also provide new sources of adaptation.

  11. Targeting hunter distribution based on host resource selection and kill sites to manage disease risk.

    Science.gov (United States)

    Dugal, Cherie J; van Beest, Floris M; Vander Wal, Eric; Brook, Ryan K

    2013-10-01

    Endemic and emerging diseases are rarely uniform in their spatial distribution or prevalence among cohorts of wildlife. Spatial models that quantify risk-driven differences in resource selection and hunter mortality of animals at fine spatial scales can assist disease management by identifying high-risk areas and individuals. We used resource selection functions (RSFs) and selection ratios (SRs) to quantify sex- and age-specific resource selection patterns of collared (n = 67) and hunter-killed (n = 796) nonmigratory elk (Cervus canadensis manitobensis) during the hunting season between 2002 and 2012, in southwestern Manitoba, Canada. Distance to protected area was the most important covariate influencing resource selection and hunter-kill sites of elk (AICw = 1.00). Collared adult males (which are most likely to be infected with bovine tuberculosis (Mycobacterium bovis) and chronic wasting disease) rarely selected for sites outside of parks during the hunting season in contrast to adult females and juvenile males. The RSFs showed selection by adult females and juvenile males to be negatively associated with landscape-level forest cover, high road density, and water cover, whereas hunter-kill sites of these cohorts were positively associated with landscape-level forest cover and increasing distance to streams and negatively associated with high road density. Local-level forest was positively associated with collared animal locations and hunter-kill sites; however, selection was stronger for collared juvenile males and hunter-killed adult females. In instances where disease infects a metapopulation and eradication is infeasible, a principle goal of management is to limit the spread of disease among infected animals. We map high-risk areas that are regularly used by potentially infectious hosts but currently underrepresented in the distribution of kill sites. We present a novel application of widely available data to target hunter distribution based on host resource

  12. Open-cut coal mining in Australia's Hunter Valley: Sustainability and the industry's economic, ecological and social implications

    Directory of Open Access Journals (Sweden)

    Drew Cottle

    2014-09-01

    Full Text Available This article questions the sustainability of open-cut coal mining in the Hunter Valley region of Australia. The issue of sustainability is examined in relation to the economic, ecological and social implications of the Hunter Valley’s open-cut coal mining industry. The article demonstrates that critical social and ecological ramifications have been overshadowed by the open-cut coal mining industry’s importance to the economy of the Hunter region and of New South Wales.

  13. Medicine and music: a note on John Hunter (1728-93) and Joseph Haydn (1732-1809).

    Science.gov (United States)

    Fu, Louis

    2010-05-01

    Joseph Haydn was a central figure in the development and growth of the European classical musical tradition in its transition from the Baroque period. John Hunter as the Founder of Scientific Surgery was a dominant figure in 18th-century British medical science. Anne Hunter née Home (1742-1821) was in her own right a figure of some eminence in the literary circles of 18th-century London. Attracted to the burgeoning medical and musical scenes of London, John Hunter married Anne Home and became a famous surgeon; Haydn became acquainted with the Hunters. The people, the opportunities and the circumstances had coincided.

  14. Anterior Hypopituitarism and Treatment Response in Hunter Syndrome: A Comparison of Two Patients

    Science.gov (United States)

    Luca, Paola; Wei, Xing-Chang; Khan, Aneal

    2016-01-01

    Hypopituitarism is a clinically important diagnosis and has not previously been reported in Hunter syndrome. We contrast two cases with anatomic pituitary anomalies: one with anterior panhypopituitarism and the other with intact pituitary function. Patient 1, a 10-year-old boy with Hunter syndrome, was evaluated for poor growth and an ectopic posterior pituitary gland. Endocrine testing revealed growth hormone (GH) deficiency, secondary adrenal insufficiency, and tertiary hypothyroidism. An improvement in growth velocity with hormone replacement (GH, thyroxine, and corticosteroid) was seen; however, final adult height remained compromised. Patient 2, a 13-year-old male with Hunter syndrome, was evaluated for growth failure. He had a large empty sella turcica with posteriorly displaced pituitary. Functional endocrine testing was normal and a trial of GH-treatment yielded no significant effect. Panhypopituitarism associated with pituitary anomalies has not been previously reported in Hunter syndrome and was an incidental finding of significant clinical importance. In the setting of documented anterior hypopituitarism, while hormone replacement improved growth velocity, final height remained impaired. In patient 2 with equivocal GH-testing results, treatment had no effect on linear growth. These cases highlight the importance of careful clinical assessment in Hunter syndrome and that judicious hormone replacement may be indicated in individual cases. PMID:28018694

  15. Applications of resilience theory in management of a moose-hunter system in Alaska

    Directory of Open Access Journals (Sweden)

    Casey L. Brown

    2015-03-01

    Full Text Available We investigated wildfire-related effects on a slow ecological variable, i.e., forage production, and fast social-ecological variables, i.e., seasonal harvest rates, hunter access, and forage offtake, in a moose-hunter system in interior Alaska. In a 1994 burn, average forage production increased slightly (5% between 2007 and 2013; however, the proportional removal across all sites declined significantly (10%. This suggests that moose are not utilizing the burn as much as they have in the past and that, as the burn has aged, the apparent habitat quality has declined. Areas with a greater proportion of accessible burned area supported both high numbers of hunters and harvested moose. Our results suggest that evaluating ecological variables in conjunction with social variables can provide managers with information to forecast management scenarios. We recommend that wildlife managers monitor fast variables frequently, e.g., annually, to adapt and keep their management responsive as resources fluctuate; whereas slower variables, which require less frequent monitoring, should be actively incorporated into long-term management strategies. Climate-driven increases in wildfire extent and severity and economically driven demographic changes are likely to increase both moose density and hunting pressure. However, the future resilience of this moose-hunter system will depend on integrated management of wildfire, hunter access, and harvest opportunities.

  16. DBD-Hunter: a knowledge-based method for the prediction of DNA-protein interactions.

    Science.gov (United States)

    Gao, Mu; Skolnick, Jeffrey

    2008-07-01

    The structures of DNA-protein complexes have illuminated the diversity of DNA-protein binding mechanisms shown by different protein families. This lack of generality could pose a great challenge for predicting DNA-protein interactions. To address this issue, we have developed a knowledge-based method, DNA-binding Domain Hunter (DBD-Hunter), for identifying DNA-binding proteins and associated binding sites. The method combines structural comparison and the evaluation of a statistical potential, which we derive to describe interactions between DNA base pairs and protein residues. We demonstrate that DBD-Hunter is an accurate method for predicting DNA-binding function of proteins, and that DNA-binding protein residues can be reliably inferred from the corresponding templates if identified. In benchmark tests on approximately 4000 proteins, our method achieved an accuracy of 98% and a precision of 84%, which significantly outperforms three previous methods. We further validate the method on DNA-binding protein structures determined in DNA-free (apo) state. We show that the accuracy of our method is only slightly affected on apo-structures compared to the performance on holo-structures cocrystallized with DNA. Finally, we apply the method to approximately 1700 structural genomics targets and predict that 37 targets with previously unknown function are likely to be DNA-binding proteins. DBD-Hunter is freely available at http://cssb.biology.gatech.edu/skolnick/webservice/DBD-Hunter/.

  17. Future Discounting in Congo Basin Hunter-Gatherers Declines with Socio-Economic Transitions.

    Directory of Open Access Journals (Sweden)

    Gul Deniz Salali

    Full Text Available Humans have a tendency to discount the future; that is we value small, short-term rewards over larger, long-term rewards. The degree of future discounting, however, changes in response to socio-ecological factors. Here, we study Mbendjele BaYaka hunter-gatherers of northern Congo and their farmer neighbours to investigate adaptations in inter-temporal preferences in humans. We argue that in immediate-return systems, where food storage is absent and egalitarianism is enforced through levelling mechanisms, future discounting is an adaptive strategy to prevent wealth accumulation and the emergence of hierarchies. This ensures food sharing and allows for survival in unpredictable environments where there is risk of an energy shortfall. On the other hand, when food storage is made possible by the emergence of agriculture or as seen in some delayed-return hunter-gatherer populations, wealth accumulation, hierarchies and lower discount rates become the adaptive strategy. Therefore, individuals in immediate-return, egalitarian societies will discount the future more than those in non-egalitarian, delayed-return societies. Consistent with the predictions we found that market integration and socio-economic transitions decrease the future discounting in Mbendjele hunter-gatherers. Our measures of socio-economic differences marked this transition in hunter-gatherers living in a logging town. The degree of future-discounting was the same between more market-integrated hunter-gatherers and their farmer neighbours.

  18. Comparing Road-Kill Datasets from Hunters and Citizen Scientists in a Landscape Context

    Directory of Open Access Journals (Sweden)

    Florian Heigl

    2016-10-01

    Full Text Available Road traffic has severe effects on animals, especially when road-kills are involved. In many countries, official road-kill data are provided by hunters or police; there are also road-kill observations reported by citizen scientists. The aim of the current study was to test whether road-kill reports by hunters stem from similar landscapes than those reported by citizen scientists. We analysed the surrounding landscapes of 712 road-kill reportings of European hares in the province of Lower Austria. Our data showed that road-killed hares reported both by hunters and citizens are predominantly surrounded by arable land. No difference of hedges and solitary trees could be found between the two datasets. However, significant differences in landcover classes and surrounding road networks indicate that hunters’ and citizen scientists’ data are different. Hunters reported hares from landscapes with significantly higher percentages of arable land, and greater lengths of secondary roads. In contrast, citizens reported hares from landscapes with significantly higher percentages of urban or industrial areas and greater lengths of motorways, primary roads, and residential roads. From this we argue that hunters tend to report data mainly from their hunting areas, whereas citizens report data during their daily routine on the way to/from work. We conclude that a citizen science approach is an important source for road-kill data when used in addition to official data with the aim of obtaining an overview of road-kill events on a landscape scale.

  19. Reducing Lead on the Landscape: Anticipating Hunter Behavior in Absence of a Free Nonlead Ammunition Program.

    Directory of Open Access Journals (Sweden)

    Loren Chase

    Full Text Available Lead is a neurotoxin that has been documented to affect many forms of wildlife, and has been identified as a limiting factor in a population of California Condors in Northern Arizona. The Arizona Game and Fish Department provides vouchers for free nonlead ammunition to hunters selected to hunt within the distribution of California Condors, with the intention of having fewer lead-laden offal piles available to California Condors. Although wildlife agencies may reasonably assume voucher programs motivate hunters into choosing nonlead ammunition, the lead reduction efforts attributable to the voucher program has not been empirically quantified. Our intention was to compare a control group of hunters to a treatment group of hunters within California Condor occupied areas. Both groups received educational materials regarding the deleterious effects of lead, but the treatment group also received a voucher for a free initial box of ammunition. About half of the control group used nonlead ammunition, compared to about three-fourths of the treatment group. Prominent barriers to adoption of nonlead ammunition included a general difficulty of obtaining it, obtaining it in the desired caliber, and its costliness. Frequently mentioned motivations for using nonlead was the exhortation to use it by the Department, and the desire to aid California Condor recovery by hunters. The disparate compliance rates found herein confirm and quantify the success of nonlead ammunition voucher programs, but underscore the importance of working to increase the supply of nonlead ammunition with the end of facilitating its procurement and reducing its cost.

  20. Anterior Hypopituitarism and Treatment Response in Hunter Syndrome: A Comparison of Two Patients

    Directory of Open Access Journals (Sweden)

    Munier A. Nour

    2016-01-01

    Full Text Available Hypopituitarism is a clinically important diagnosis and has not previously been reported in Hunter syndrome. We contrast two cases with anatomic pituitary anomalies: one with anterior panhypopituitarism and the other with intact pituitary function. Patient 1, a 10-year-old boy with Hunter syndrome, was evaluated for poor growth and an ectopic posterior pituitary gland. Endocrine testing revealed growth hormone (GH deficiency, secondary adrenal insufficiency, and tertiary hypothyroidism. An improvement in growth velocity with hormone replacement (GH, thyroxine, and corticosteroid was seen; however, final adult height remained compromised. Patient 2, a 13-year-old male with Hunter syndrome, was evaluated for growth failure. He had a large empty sella turcica with posteriorly displaced pituitary. Functional endocrine testing was normal and a trial of GH-treatment yielded no significant effect. Panhypopituitarism associated with pituitary anomalies has not been previously reported in Hunter syndrome and was an incidental finding of significant clinical importance. In the setting of documented anterior hypopituitarism, while hormone replacement improved growth velocity, final height remained impaired. In patient 2 with equivocal GH-testing results, treatment had no effect on linear growth. These cases highlight the importance of careful clinical assessment in Hunter syndrome and that judicious hormone replacement may be indicated in individual cases.

  1. 78 FR 45957 - Notice of Inventory Completion: Columbia University, Department of Anthropology, New York, NY

    Science.gov (United States)

    2013-07-30

    ..., Columbia University, New York, NY 10027, telephone (212) 854-4977, email roth@columbia.edu . SUPPLEMENTARY... York, NY 10027, telephone (212) 854-4977, email roth@columbia.edu , by August 29, 2013. After that...

  2. Evaluering af ny kokkeuddannelse for hørehandicappede

    DEFF Research Database (Denmark)

    Hansen, Niels-Henrik Møller

    2010-01-01

    Center for Ungdomsforskning har netop afsluttet en evaluering af en ny uddannelse indenfor madproduktion, rettet imod personer med et hørehandicap. Hensigten med uddannelsen er, at kunne tilbyde døve, døvblinde og hørehæmmede personer et uddannelsestilbud indenfor fremstilling af mad. Konkret han...

  3. 78 FR 44187 - New York Disaster # NY-00136

    Science.gov (United States)

    2013-07-23

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION New York Disaster NY-00136 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... locations. The following areas have been determined to be adversely affected by the disaster:...

  4. Evaluering af ny kokkeuddannelse for hørehandicappede

    DEFF Research Database (Denmark)

    Hansen, Niels-Henrik Møller

    2010-01-01

    Center for Ungdomsforskning har netop afsluttet en evaluering af en ny uddannelse indenfor madproduktion, rettet imod personer med et hørehandicap. Hensigten med uddannelsen er, at kunne tilbyde døve, døvblinde og hørehæmmede personer et uddannelsestilbud indenfor fremstilling af mad. Konkret han...

  5. Kapitalismens dna i ny oversættelse

    DEFF Research Database (Denmark)

    Schanz, Hans-Jørgen

    2013-01-01

    Adam Smiths klassiske storværk om kapitalismen ’Nationernes velstand’ havde stor indflydelse på socialfilosofien, på Hegel, på Marx og liberaløkonomerne. Ny oversættelse yder omsider værket fuld respekt på dansk. Anmeldelse af: Adam Smith: Nationernes velstand. 441+ 519 sider. 699,95 kr. Informat...

  6. 78 FR 7848 - New York Disaster Number NY-00130

    Science.gov (United States)

    2013-02-04

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION New York Disaster Number NY-00130 AGENCY: U.S. Small Business Administration. ACTION: Amendment 5.... Small Business Administration, Processing and Disbursement Center, 14925 Kingsport Road, Fort Worth,...

  7. Ny international efteruddannelse for fødevaresektoren

    DEFF Research Database (Denmark)

    Stacey, Julia; Brunsø, Karen

    2003-01-01

    Ny MBA på Handelshøjskolen i Århus stiller skarpt på fødevaresektoren. MBA - med fokus på fødevaresektoren henvender sig til personer med minimum tre års ledererfaring, der ønsker nye erhvervsrettede kompetencer på højt niveau....

  8. Kapitalismens dna i ny oversættelse

    DEFF Research Database (Denmark)

    Schanz, Hans-Jørgen

    2013-01-01

    Adam Smiths klassiske storværk om kapitalismen ’Nationernes velstand’ havde stor indflydelse på socialfilosofien, på Hegel, på Marx og liberaløkonomerne. Ny oversættelse yder omsider værket fuld respekt på dansk. Anmeldelse af: Adam Smith: Nationernes velstand. 441+ 519 sider. 699,95 kr. Informat...

  9. Interoperability of Demand Response Resources Demonstration in NY

    Energy Technology Data Exchange (ETDEWEB)

    Wellington, Andre

    2014-03-31

    The Interoperability of Demand Response Resources Demonstration in NY (Interoperability Project) was awarded to Con Edison in 2009. The objective of the project was to develop and demonstrate methodologies to enhance the ability of customer sited Demand Response resources to integrate more effectively with electric delivery companies and regional transmission organizations.

  10. 77 FR 50630 - Radio Broadcasting Services; Westfield, NY

    Science.gov (United States)

    2012-08-22

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Westfield, NY AGENCY: Federal Communications... Review Act, see 5 U.S.C. 801(a)(1)(A). List of Subjects in 47 CFR Part 73 Radio, Radio...

  11. NY-ESO-1 cancer testis antigen demonstrates high immunogenicity in triple negative breast cancer.

    Science.gov (United States)

    Ademuyiwa, Foluso O; Bshara, Wiam; Attwood, Kristopher; Morrison, Carl; Edge, Stephen B; Karpf, Adam R; James, Smith A; Ambrosone, Christine B; O'Connor, Tracey L; Levine, Ellis G; Miliotto, Anthony; Ritter, Erika; Ritter, Gerd; Gnjatic, Sacha; Odunsi, Kunle

    2012-01-01

    NY-ESO-1 cancer testis (CT) antigen is an attractive candidate for immunotherapy as a result of its high immunogenicity. The aim of this study was to explore the potential for NY-ESO-1 antigen directed immunotherapy in triple negative breast cancer (TNBC) by determining the frequency of expression by immunohistochemistry (IHC) and the degree of inherent immunogenicity to NY-ESO-1. 168 TNBC and 47 ER+/HER2- primary breast cancer specimens were used to determine NY-ESO-1 frequency by IHC. As previous studies have shown that patients with a robust innate humoral immune response to CT antigens are more likely to develop CD8 T-cell responses to NY-ESO-1 peptides, we evaluated the degree to which patients with NY-ESO-1 expression had inherent immunogenicity by measuring antibodies. The relationship between NY-ESO-1 expression and CD8+ T lymphocytes was also examined. The frequency of NY-ESO-1 expression in the TNBC cohort was 16% versus 2% in ER+/HER2- patients. A higher NY-ESO-1 score was associated with a younger age at diagnosis in the TNBC patients with NY-ESO-1 expression (p = 0.026). No differences in OS (p = 0.278) or PFS (p = 0.238) by NY-ESO-1 expression status were detected. Antibody responses to NY-ESO-1 were found in 73% of TNBC patients whose tumors were NY-ESO-1 positive. NY-ESO-1 positive patients had higher CD8 counts than negative patients (p = 0.018). NY-ESO-1 is expressed in a substantial subset of TNBC patients and leads to a high humoral immune response in a large proportion of these individuals. Given these observations, patients with TNBC may benefit from targeted therapies directed against NY-ESO-1.

  12. 33 CFR 207.60 - Federal Dam, Hudson River, Troy, N.Y.; pool level.

    Science.gov (United States)

    2010-07-01

    ..., N.Y.; pool level. 207.60 Section 207.60 Navigation and Navigable Waters CORPS OF ENGINEERS..., N.Y.; pool level. (a) Whenever the elevation of the pool created by the Federal dam at Troy, N.Y... automatically when the pool level rises to an elevation of +18.5 feet mean sea level, and conform in...

  13. 76 FR 20532 - Safety Zone; Boom Days, Niagara River, Niagara Falls, NY

    Science.gov (United States)

    2011-04-13

    ..., Niagara River, Niagara Falls, NY AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on the Niagara River, Niagara Falls, NY for the Boom... Niagara River, Niagara Falls, NY during the Boom Days Fireworks on April 16, 2011. This temporary...

  14. Planet Hunters: Assessing the Kepler Inventory of Short-period Planets

    Science.gov (United States)

    Schwamb, Megan E.; Lintott, Chris J.; Fischer, Debra A.; Giguere, Matthew J.; Lynn, Stuart; Smith, Arfon M.; Brewer, John M.; Parrish, Michael; Schawinski, Kevin; Simpson, Robert J.

    2012-08-01

    We present the results from a search of data from the first 33.5 days of the Kepler science mission (Quarter 1) for exoplanet transits by the Planet Hunters citizen science project. Planet Hunters enlists members of the general public to visually identify transits in the publicly released Kepler light curves via the World Wide Web. Over 24,000 volunteers reviewed the Kepler Quarter 1 data set. We examine the abundance of >=2 R ⊕ planets on short-period (=4 R ⊕ Planet Hunters >=85% efficient at identifying transit signals for planets with periods less than 15 days for the Kepler sample of target stars. Our high efficiency rate for simulated transits along with recovery of the majority of Kepler >=4 R ⊕ planets suggests that the Kepler inventory of >=4 R ⊕ short-period planets is nearly complete.

  15. Ancient DNA reveals lack of continuity between neolithic hunter-gatherers and contemporary Scandinavians

    DEFF Research Database (Denmark)

    Malmström, Helena; Gilbert, M Thomas P; Thomas, Mark G

    2009-01-01

    The driving force behind the transition from a foraging to a farming lifestyle in prehistoric Europe (Neolithization) has been debated for more than a century [1-3]. Of particular interest is whether population replacement or cultural exchange was responsible [3-5]. Scandinavia holds a unique pla......]. Furthermore, our data are consistent with the view that the eastern Baltic represents a genetic refugia for some of the European hunter-gatherer populations....... in this debate, for it maintained one of the last major hunter-gatherer complexes in Neolithic Europe, the Pitted Ware culture [6]. Intriguingly, these late hunter-gatherers existed in parallel to early farmers for more than a millennium before they vanished some 4,000 years ago [7, 8]. The prolonged coexistence...

  16. Zoonotic disease risk and the bushmeat trade: assessing awareness among hunters and traders in Sierra Leone.

    Science.gov (United States)

    Subramanian, Melanie

    2012-12-01

    The bushmeat industry has been a topic of increasing importance among both conservationists and public health officials for its influence on zoonotic disease transmission and animal conservation. While the association between infectious diseases and the bushmeat trade is well established in the research community, risk perception among bushmeat hunters and traders has not been well characterized. I conducted surveys of 123 bushmeat hunters and traders in rural Sierra Leone to investigate hunting practices and awareness of zoonotic disease risk associated with the bushmeat trade. Twenty-four percent of bushmeat hunters and traders reported knowledge of disease transmission from animals to humans. Formal education did not significantly affect awareness of zoonotic disease transmission. Individuals who engaged exclusively in preparation and trading of bushmeat were more likely to accidentally cut themselves compared to those who primarily engaged in bushmeat hunting (P zoonotic pathogens through accidental self-cutting compared to men (P zoonotic disease transmission risk among vulnerable communities.

  17. Clarifying beliefs underlying hunter intentions to support a ban on lead shot

    Science.gov (United States)

    Schroeder, Susan A.; Fulton, David C.; Doncarlos, Kathy

    2016-01-01

    Shot from hunting adds toxic lead to environments worldwide. Existing lead shot regulations have been instituted with little understanding of hunter beliefs and attitudes. This study applied the Theory of Reasoned Action, using a multilevel, multivariate approach, to clarify how positive and negative beliefs relate to attitudes about a ban on lead shot. Structure coefficients and commonality analysis were employed to further examine relationships between beliefs and attitudes. Results suggest that while both positive and negative outcomes influence attitudes, positive outcomes were more influential for supporters and negative beliefs for opposers. Management may need to focus on the results from hunters who indicated that they would be unlikely to support a ban, as these hunters include those who may actively oppose additional efforts to regulate lead.

  18. Ethical acceptability of recreational hunting - does the motive of the hunter matter?

    DEFF Research Database (Denmark)

    Gamborg, Christian; Jensen, Frank Søndergaard; Sandøe, Peter

    2016-01-01

    ,001) and hunters (n=1,130) in Denmark. In this survey just under half of the general public indicated that the hunters’ motives affected their attitude to the acceptability of hunting. A significant difference in wildlife value orientations was found between the two groups. Motives relating to nature, the social...... is to assess the extent to which the perceived motive for recreational hunting plays a role in its public acceptance. We also compare public perceptions of the importance of motive with those of hunters. We conducted a nationally representative survey (web-based questionnaires) of the general public (n=1......’, ‘the sport’, ‘the excitement’, and ‘to kill’ to recreational hunting to a much greater degree than the hunters themselves; and these motives were associated with lower assessments of the acceptability of recreational hunting among the public. The mismatch between presumed and professed motives among...

  19. Radioiodination and biodistribution of quantum dots using Bolton-Hunter reagent

    Energy Technology Data Exchange (ETDEWEB)

    Jun Park, Jae [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), 215-4 Gongneung-Dong, Nowon-Gu, Seoul 139-706 (Korea, Republic of); Sup Lee, Tae, E-mail: nobelcow@kirams.re.k [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), 215-4 Gongneung-Dong, Nowon-Gu, Seoul 139-706 (Korea, Republic of); Hyun Kang, Joo [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), 215-4 Gongneung-Dong, Nowon-Gu, Seoul 139-706 (Korea, Republic of); Song, Rita [Nano/Bio Chemistry Group, Institut Pasteur Korea (IP-Korea), Seongnam 463-400 (Korea, Republic of); Jeong Cheon, Gi, E-mail: larry@kirams.re.k [Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), 215-4 Gongneung-Dong, Nowon-Gu, Seoul 139-706 (Korea, Republic of); Department of Nuclear medicine, Korea Institute of Radiological and Medical Sciences (KIRAMS), 215-4 Gongneung-Dong, Nowon-Gu, Seoul 139-706 (Korea, Republic of)

    2011-01-15

    In this study, the radioiodination and biodistribution of quantum dots (QDs) using Bolton-Hunter reagent were investigated. Radioiodination yield was 33.4{+-}2.0%. Fluorescent intensity of radioiodinated QDs decreased to 75.4% of the maximum prior to radioiodination. In biodistribution and ex vivo fluorescence imaging, radioiodinated QDs were highly accumulated in reticuloendothelial system (liver and spleen) and had low level bone uptakes and slow clearance from body. These results suggest that the radioiodination method of nanoparticles using Bolton-Hunter reagent could be easily used in the biodistribution and quantification of nanoparticles in vivo.

  20. 利用Hunter-Lab色差仪测量彩涂板的色差

    Institute of Scientific and Technical Information of China (English)

    李红军; 陈剑; 王文杰; 曹彦婷

    2006-01-01

    介绍了利用Hunter-Lab色差仪对彩涂板进行色差测量的方法和原理,并对该方法的准确度和精密度进行了分析.结果表明,利用Hunter-Lab色差仪可快速准确的测量彩涂板色差,对彩涂板的生产具有极强的指导意义.

  1. Generic regularity and Lipschitz metric for the Hunter-Saxton type equations

    Science.gov (United States)

    Cai, Hong; Chen, Geng; Shen, Yannan; Tan, Zhong

    2017-01-01

    The Hunter-Saxton equation determines a flow of conservative solutions taking values in the space H1 (R+). However, the solution typically includes finite time gradient blowups, which make the solution flow not continuous w.r.t. the natural H1 distance. The aim of this paper is to first study the generic properties of conservative solutions of some initial boundary value problems to the Hunter-Saxton type equations. Then using these properties, we give a new way to construct a Finsler type metric which renders the flow uniformly Lipschitz continuous on bounded subsets of H1 (R+).

  2. Molecular characterization of Histoplasma capsulatum isolated from an outbreak in treasure hunters Histoplasma capsulatum in treasure hunters

    Directory of Open Access Journals (Sweden)

    Muñoz Bertha

    2010-09-01

    Full Text Available Abstract Background In Mexico, primary pulmonary histoplasmosis is the most relevant clinical form of the disease. The geographical distribution of specific strains of Histoplasma capsulatum circulating in Mexico has not been fully established. Outbreaks must be reported in order to have current, updated information on this disease, identifying new endemic areas, manner of exposure to the fungi, and molecular characterization of the causative agents. We report a recent outbreak of histoplasmosis in treasure hunters and the molecular characterization of two isolates obtained from these patients. Methods Six patients admitted to the National Institute of Respiratory Diseases (INER in Mexico City presented severe respiratory symptoms suggestive of histoplasmosis. They acquired the infection in the Veracruz (VZ endemic zone. Diagnosis was made by X-ray and Computed tomography (CT, liver function, immunological techniques, and culture. Identification of H. capsulatum isolates was confirmed by using Polymerase chain reaction (PCR was conducted with a probe from the M antigen, and the isolates were characterized by means of Random amplification of polymorphic DNA (RAPD-PCR employed the 1253 oligonucleotide and a mixture of oligonucleotides 1281 and 1283. These were compared to eight reference strain isolates from neighboring areas. Results X-ray and CT revealed disseminated micronodular images throughout lung parenchyma, as well as bilateral retrocaval, prevascular, subcarinal, and hilar adenopathies, hepatosplenomegaly, and altered liver function tests. Five of the six patients developed disseminated histoplasmosis. Two H. capsulatum strains were isolated. The same band profile was detected in both strains, indicating that both isolates corresponded to the sole H. capsulatum strain. Molecular characterization of the isolates was similar in 100% with the EH-53 Hidalgo human (HG strain (reference strain integrated into the LAm A clade described for

  3. Hunter-Schmidt Meta-Analysis Paradigm: Its Properties and Applications%Hunter-Schmidt元分析范式:特征和应用

    Institute of Scientific and Technical Information of China (English)

    王拥军; 俞国良

    2010-01-01

    Hunter-Schmidt元分析范式是一种以随机效应模型为基础的比较完备的元分析技术,可以校正效应值的抽样误差、测量误差和全距误差.Hunter-Schmidt元分析范式是应用心理学领域30年来最重要的进展之一,它拓展了心理学的研究方法,开创了校正各种测验误差的方法论研究,激励了心理学家对预测因子的效度概化研究,确认了预测因子和效标之间的水平关系特征和结构关系特征.

  4. Sunday Schools and English Teaching: Re-Reading Ian Hunter and the Emergence of "English" in the United States

    Science.gov (United States)

    Brass, Jory

    2011-01-01

    This article represents an "overdue encounter" with the ideas of Ian Hunter to reconsider the historical emergence and descent of English teaching in the United States. Influenced by Hunter's account of the "pastoral" and "bureaucratic" genealogy of English teaching in England, my historical study documented…

  5. Flyway Habitat Management Unit Project report no. 11: The extent that waterfowl hunting space met the needs of waterfowl hunters in 1965

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — To determine the adequacy of waterfowl hunting space, it is necessary to compare the number of hunters that space available can support with the number of hunters...

  6. Geothermal energy and district heating in Ny-Ålesund, Svalbard

    OpenAIRE

    Iversen, Julianne

    2013-01-01

    This thesis presents the possibilities for using shallow geothermal energy for heating purposes in Ny-Ålesund. The current energy supply in Ny-Ålesund is a diesel generator, which does not comply with the Norwegian government and Ny-Ålesund Science Managers Committee’s common goal to maintain the natural environment in Ny-Ålesund. Ny-Ålesund has a potential for replacing the heat from the current diesel based energy source with geothermal energy. Geothermal energy is considered to have low im...

  7. Non-viral transfer approaches for the gene therapy of mucopolysaccharidosis type II (Hunter syndrome).

    Science.gov (United States)

    Tomanin, R; Friso, A; Alba, S; Piller Puicher, E; Mennuni, C; La Monica, N; Hortelano, G; Zacchello, F; Scarpa, M

    2002-01-01

    Hunter syndrome is a rare X-linked lysosomal storage disorder caused by the deficiency of the housekeeping enzyme iduronate-2-sulphatase (IDS). Deficiency of IDS causes accumulation of undegraded dermatan and heparan-sulphate in various tissues and organs. Approaches have been proposed for the symptomatic therapy of the disease, including bone marrow transplantation and, very recently, enzyme replacement. To date, gene therapy strategies have considered mainly retroviral and adenoviral transduction of the correct cDNA. In this paper, two non-viral somatic gene therapy approaches are proposed: encapsulated heterologous cells and muscle electro-gene transfer (EGT). Hunter primary fibroblasts were co-cultured with either cell clones over-expressing the lacking enzyme or with the same incorporated in alginate microcapsules. For EGT, plasmid vector was injected into mouse quadriceps muscle, which was then immediately electro-stimulated. Co-culturing Hunter primary fibroblasts with cells over-expressing IDS resulted in a three- to fourfold increase in fibroblast enzyme activity with respect to control cells. Fibroblast IDS activity was also increased after co-culture with encapsulated cells. EGT was able to transduce genes in mouse muscle, resulting in at least a tenfold increase in IDS activity 1-5 weeks after treatment. Although preliminary, results from encapsulated heterologous cell clones and muscle EGT encourage further evaluations for possible application to gene therapy for Hunter syndrome.

  8. PLANET HUNTERS: ASSESSING THE KEPLER INVENTORY OF SHORT-PERIOD PLANETS

    Energy Technology Data Exchange (ETDEWEB)

    Schwamb, Megan E. [Yale Center for Astronomy and Astrophysics, Yale University, P.O. Box 208121, New Haven, CT 06520 (United States); Lintott, Chris J.; Lynn, Stuart; Smith, Arfon M.; Simpson, Robert J. [Oxford Astrophysics, Denys Wilkinson Building, Keble Road, Oxford OX1 3RH (United Kingdom); Fischer, Debra A.; Giguere, Matthew J.; Brewer, John M. [Department of Astronomy, Yale University, New Haven, CT 06511 (United States); Parrish, Michael [Adler Planetarium, 1300 S. Lake Shore Drive, Chicago, IL 60605 (United States); Schawinski, Kevin, E-mail: megan.schwamb@yale.edu [Department of Physics, Yale University, New Haven, CT 06511 (United States)

    2012-08-01

    We present the results from a search of data from the first 33.5 days of the Kepler science mission (Quarter 1) for exoplanet transits by the Planet Hunters citizen science project. Planet Hunters enlists members of the general public to visually identify transits in the publicly released Kepler light curves via the World Wide Web. Over 24,000 volunteers reviewed the Kepler Quarter 1 data set. We examine the abundance of {>=}2 R{sub Circled-Plus} planets on short-period (<15 days) orbits based on Planet Hunters detections. We present these results along with an analysis of the detection efficiency of human classifiers to identify planetary transits including a comparison to the Kepler inventory of planet candidates. Although performance drops rapidly for smaller radii, {>=}4 R{sub Circled-Plus} Planet Hunters {>=}85% efficient at identifying transit signals for planets with periods less than 15 days for the Kepler sample of target stars. Our high efficiency rate for simulated transits along with recovery of the majority of Kepler {>=}4 R{sub Circled-Plus} planets suggests that the Kepler inventory of {>=}4 R{sub Circled-Plus} short-period planets is nearly complete.

  9. Teaching Experientially with the Madeline Hunter Method: An Application in a Marketing Research Course

    Science.gov (United States)

    Burns, Alvin C.

    2006-01-01

    Due to concerns about the disparity of learning and the high nonresponse rates encountered by student marketing research teams working with sponsors, the author adopted the Hunter Method to restructure his course. This method requires the use of a model onto which students can map their learning via guided practice as well as independent practice.…

  10. Teaching Experientially with the Madeline Hunter Method: An Application in a Marketing Research Course

    Science.gov (United States)

    Burns, Alvin C.

    2006-01-01

    Due to concerns about the disparity of learning and the high nonresponse rates encountered by student marketing research teams working with sponsors, the author adopted the Hunter Method to restructure his course. This method requires the use of a model onto which students can map their learning via guided practice as well as independent practice.…

  11. The seed hunter in het spoor van Vavilov (interview met C. Kik)

    NARCIS (Netherlands)

    Zanderink, R.; Kik, C.

    2013-01-01

    Er moet voor een veredelaar een grote variatie aan plantmateriaal aanwezig zijn om uit te kunnen putten zodat onze gewassen, die vaak bestaan uit monoculturen, voor de toekomst veiliggesteld worden. Het vinden van die variatie is het werk van seed hunters of zadenverzamelaars. Eén van die seed

  12. The Oxford Handbook of the Archaeology and Anthropology of Hunter-Gatherers

    NARCIS (Netherlands)

    Cummings, Vicky; Jordan, Peter; Zvelebil, Marek

    2014-01-01

    For more than a century, the study of hunting and gathering societies has been central to the development of both archaeology and anthropology as academic disciplines, and has also generated widespread public interest and debate. The Oxford Handbook of the Archaeology and Anthropology of Hunter-Gath

  13. Big game hunting practices, meanings, motivations and constraints: a survey of Oregon big game hunters

    Science.gov (United States)

    Suresh K. Shrestha; Robert C. Burns

    2012-01-01

    We conducted a self-administered mail survey in September 2009 with randomly selected Oregon hunters who had purchased big game hunting licenses/tags for the 2008 hunting season. Survey questions explored hunting practices, the meanings of and motivations for big game hunting, the constraints to big game hunting participation, and the effects of age, years of hunting...

  14. Recent origin and cultural reversion of a hunter-gatherer group.

    Directory of Open Access Journals (Sweden)

    Hiroki Oota

    2005-03-01

    Full Text Available Contemporary hunter-gatherer groups are often thought to serve as models of an ancient lifestyle that was typical of human populations prior to the development of agriculture. Patterns of genetic variation in hunter-gatherer groups such as the Kung and African Pygmies are consistent with this view, as they exhibit low genetic diversity coupled with high frequencies of divergent mtDNA types not found in surrounding agricultural groups, suggesting long-term isolation and small population sizes. We report here genetic evidence concerning the origins of the Mlabri, an enigmatic hunter-gatherer group from northern Thailand. The Mlabri have no mtDNA diversity, and the genetic diversity at Y-chromosome and autosomal loci are also extraordinarily reduced in the Mlabri. Genetic, linguistic, and cultural data all suggest that the Mlabri were recently founded, 500-800 y ago, from a very small number of individuals. Moreover, the Mlabri appear to have originated from an agricultural group and then adopted a hunting-gathering subsistence mode. This example of cultural reversion from agriculture to a hunting-gathering lifestyle indicates that contemporary hunter-gatherer groups do not necessarily reflect a pre-agricultural lifestyle.

  15. Period Determination of Binary Asteroid Targets Observed at Hunters Hill Observatory: May-September 2009

    Science.gov (United States)

    Higgins, David; Oey, Julian; Pravec, Petr

    2011-01-01

    Lightcurves for seven confirmed or possible binary asteroids were obtained at the Hunters Hill Observatory (HHO) and Leura Observatory from 2009 May through 2010 September: 1453 Fennia, 2501 Lohja, 3076 Garbor, 4029 Bridges, 5325 Silver, 6244 Okamoto, and (6265) 1985 TW3.

  16. A Guide to Instruction in the Shooting Sports-Rifles; Air Rifles; Shotguns; Pistols; Hunter Safety.

    Science.gov (United States)

    Niemeyer, Roy K.; And Others

    Prepared for instruction in the use of rifles, air guns, shotguns, pistols, and hunter safety, this guide supplements other materials which are available from the National Rifle Association of America, the National Shooting Sports Foundation, the American Association for Health, Physical Education, and Recreation, industry, and other sources. The…

  17. Using the Madeline Hunter Direct Instruction Model to Improve Outcomes Assessments in Marketing Programs

    Science.gov (United States)

    Steward, Michelle D.; Martin, Gregory S.; Burns, Alvin C.; Bush, Ronald F.

    2010-01-01

    This study introduces marketing educators to the Madeline Hunter Direct Instruction Model (HDIM) as an approach to significantly and substantially improve student learning through course-embedded assessment. The effectiveness of the method is illustrated in three different marketing courses taught by three different marketing professors. The…

  18. Adaptation of Hunter Cynism Scale to Turkish: Validity and Reliability Study

    Science.gov (United States)

    Kiraz, Zafer; Bakioglu, Fuad

    2016-01-01

    The aim of this study is to carry out the adaptation of Hunter Cynicism Scale to Turkish. For this purpose, this study consists of two stages. 311 university students participated in for the first stage and 313 university students participated in for the second stage of this study. In the first stage, translation, exploratory factor analysis,…

  19. 76 FR 9345 - Brian Hunter; Third Supplemental Notice of Designation of Commission Staff

    Science.gov (United States)

    2011-02-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Brian Hunter; Third Supplemental Notice of Designation of Commission Staff On February 1, 2008, the Commission issued an order that, inter alia, designated the staff of...

  20. History and Development of the Schmidt-Hunter Meta-Analysis Methods

    Science.gov (United States)

    Schmidt, Frank L.

    2015-01-01

    In this article, I provide answers to the questions posed by Will Shadish about the history and development of the Schmidt-Hunter methods of meta-analysis. In the 1970s, I headed a research program on personnel selection at the US Office of Personnel Management (OPM). After our research showed that validity studies have low statistical power, OPM…

  1. Geometric Integrability of Two-Component Camassa-Holm and Hunter-Saxton Systems

    Institute of Scientific and Technical Information of China (English)

    SONG Juu-Feng; QU Chang-Zheng

    2011-01-01

    It is shown that the two-component Camassa-Holm and Hunter-Saxton systems are geometrically integrable, namely they describe pseudo-spherical surfaces. As a consequence, their infinite number o, conservation laws are directly constructed. In addition, a class of nonlocal symmetries depending on the pseudo-potentials are obtained.

  2. Targeting hunter distribution based on host resource selection and kill sites to manage disease risk

    DEFF Research Database (Denmark)

    Dugal, Cherie; van Beest, Floris; Vander Wal, Eric

    2013-01-01

    Endemic and emerging diseases are rarely uniform in their spatial distribution or prevalence among cohorts of wildlife. Spatial models that quantify risk-driven differences in resource selection and hunter mortality of animals at fine spatial scales can assist disease management by identifying hi...

  3. Ny forskning: Derfor virker ros ikke mod stress

    DEFF Research Database (Denmark)

    Pedersen, Pernille

    2015-01-01

    Ny forskning peger på, at stressede medarbejdere overhører din ros og anerkendelse, hvis de føler skam. Skam over ikke at kunne slå til på arbejdet. Vil du hjælpe en stresset medarbejder, skal du forebygge, at de føler sig skamfulde. Læs her anbefalinger til, hvordan du bedst hjælper din stressed...

  4. Characterization of the near-Earth Asteroid 2002NY40

    OpenAIRE

    Roberts, Jr., Lewis C.; Hall, Doyle T.; Lambert, John V.; Africano, John L.; Knox, Keith T.; Barros, Jacob K.; Hamada, Kris M.; Liang, Dennis; Sydney, Paul F.; Kervin, Paul

    2007-01-01

    In August 2002, the near-Earth asteroid 2002 NY40, made its closest approach to the Earth. This provided an opportunity to study a near-Earth asteroid with a variety of instruments. Several of the telescopes at the Maui Space Surveillance System were trained at the asteroid and collected adaptive optics images, photometry and spectroscopy. Analysis of the imagery reveals the asteroid is triangular shaped with significant self-shadowing. The photometry reveals a 20-hour period and the spectros...

  5. Den fjerde vej: Trumps sejr skaber ny samfundsorden

    DEFF Research Database (Denmark)

    Rasmussen, Martin Møller Boje; Andersen, Torben K.; Kragh, Claus

    2016-01-01

    Bag Donald Trumps uempatiske retorik gemmer sig omridset af et politisk projekt, man kan kalde den fjerde vej. USA’s kommende præsident blander højre- og venstreorienterede mærkesager til et nyt nationalsocialt politisk koncept. Spørgsmålet er, om Trumps fjerde vej er et seriøst bud på en ny...

  6. Serological surveillance of vector-borne and zoonotic diseases among hunters in eastern Poland

    Directory of Open Access Journals (Sweden)

    Małgorzata Tokarska-Rodak

    2016-01-01

    Full Text Available Background & objectives: Many etiological agents of zoonoses are considered as significant biological hazard to people visiting forested areas frequently, for instance, hunters. They may be exposed to ticks, rodents, and birds as well as excreta/secretions of wild animals or contaminated water and soil. Hence, this population is at risk of contracting infection with pathogens such as Borrelia burgdorferi sensu lato (s.l., Anaplasma phagocytophilum, Babesia spp., tick-borne encephalitis virus, Bartonella spp., Francisella tularensis, Echinococcus spp., or hantaviruses. The aim of the study was to assess the seroprevalence of zoonotic agents, viz. A. phagocytophilum, hantaviruses, and Echinococcus spp., with special regard to B. burgdorferi s.l., among hunters in Lubelskie Voivodeship (eastern Poland. Methods: Serum samples collected from 134 hunters from Lubelskie Voivodeship were analyzed with the use of immunological techniques (enzyme-linked immunosorbent assay, line immunoblot test, and indirect fluorescence assay for the presence of antibodies against the agents. Results: Specific antibodies were detected in 66% of the tested individuals. Antibodies against B. burgdorferi s.l. (39%, A. phagocytophilum (30%, hantaviruses (9%, and Echinococcus spp. (8% were detected individually or as mixed results. Interpretation & conclusion: The results confirm that there is a risk of exposure to different pathogens in the forested areas in eastern Poland and that hunters are highly vulnerable to infection with the examined zoonotic agents. A significant proportion of co-occurring antibodies against different pathogens was noticed. Thus, hunters have to take special care of their health status evaluation and mitigate the exposure risk by using adequate prophylaxis measures.

  7. Response of moose hunters to predation following wolf return in Sweden.

    Directory of Open Access Journals (Sweden)

    Camilla Wikenros

    Full Text Available Predation and hunter harvest constitute the main mortality factors affecting the size and dynamics of many exploited populations. The re-colonization by wolves (Canis lupus of the Scandinavian Peninsula may therefore substantially reduce hunter harvest of moose (Alces alces, the main prey of wolves.We examined possible effects of wolf presence on hunter harvest in areas where we had data before and after wolf establishment (n = 25, and in additional areas that had been continuously exposed to wolf predation during at least ten years (n = 43. There was a general reduction in the total number of moose harvested (n = 31,827 during the ten year study period in all areas irrespective of presence of wolves or not. However, the reduction in hunter harvest was stronger within wolf territories compared to control areas without wolves. The reduction in harvest was larger in small (500-800 km2 compared to large (1,200-1,800 km2 wolf territories. In areas with newly established wolf territories moose management appeared to be adaptive with regard to both managers (hunting quotas and to hunters (actual harvest. In these areas an instant reduction in moose harvest over-compensated the estimated number of moose killed annually by wolves and the composition of the hunted animals changed towards a lower proportion of adult females.We show that the re-colonization of wolves may result in an almost instant functional response by another large predator-humans-that reduced the potential for a direct numerical effect on the density of wolves' main prey, the moose. Because most of the worlds' habitat that will be available for future colonization by large predators are likely to be strongly influenced by humans, human behavioural responses may constitute a key trait that govern the impact of large predators on their prey.

  8. NY-ESO-1 antibody as a novel tumour marker of gastric cancer.

    Science.gov (United States)

    Fujiwara, S; Wada, H; Kawada, J; Kawabata, R; Takahashi, T; Fujita, J; Hirao, T; Shibata, K; Makari, Y; Iijima, S; Nishikawa, H; Jungbluth, A A; Nakamura, Y; Kurokawa, Y; Yamasaki, M; Miyata, H; Nakajima, K; Takiguchi, S; Nakayama, E; Mori, M; Doki, Y

    2013-03-19

    NY-ESO-1 antibodies are specifically observed in patients with NY-ESO-1-expressing tumours. We analysed whether the NY-ESO-1 humoral immune response is a useful tumour marker of gastric cancer. Sera from 363 gastric cancer patients were screened by enzyme-linked immunosorbent assay (ELISA) to detect NY-ESO-1 antibodies. Serial serum samples were obtained from 25 NY-ESO-1 antibody-positive patients, including 16 patients with curative resection and 9 patients who received chemotherapy alone. NY-ESO-1 antibodies were detected in 3.4% of stage I, 4.4% of stage II, 25.3% of stage III, and 20.0% of stage IV patients. The frequency of antibody positivity increased with disease progression. When the NY-ESO-1 antibody was used in combination with carcinoembryonic antigen and CA19-9 to detect gastric cancer, information gains of 11.2% in stages III and IV, and 5.8% in all patients were observed. The NY-ESO-1 immune response levels of the patients without recurrence fell below the cutoff level after surgery. Two of the patients with recurrence displayed incomplete decreases. The nine patients who received chemotherapy alone continued to display NY-ESO-1 immune responses. When combined with conventional tumour markers, the NY-ESO-1 humoral immune response could be a useful tumour marker for detecting advanced gastric cancer and inferring the post-treatment tumour load in seropositive patients.

  9. NY-ESO-1 expression and immunogenicity in prostate cancer patients.

    Science.gov (United States)

    Gati, Asma; Lajmi, Nesrine; Derouiche, Amine; Marrakchi, Raja; Chebil, Mohamed; Benammar-Elgaaied, Amel

    2011-10-01

    Prostate cancer is the second leading cause of men cancer-related death. Cancer immunotherapy has been investigated as a treatment which might be instituted at the point of detection of androgen-independent metastatic disease. to investigate the expression and humoral response against NYESO-1 in patients with prostate cancer (PC) and to analyze the relationship between expression of NY-ESO-1 and clinicopathological features. NY-ESO-1 mRNA in surgically resected PC and benign prostatic hyperplasia (BPH) were examined by reverse transcriptionpolymerase chain reaction. The antibody response to NY-ESO-1 was examined by enzyme-linked Elisa assay using recombinant NYESO-1 protein. NY-ESO-1 mRNA was detected in 9 of 23 (39%) PC patients. Antibodies against NY-ESO-1 protein were detected in 12 of 23 (52%) sera of PC patients and in 5 of 9 (55%) of NY-ESO-1 expressing tumors. However, no mRNA copy or NY-ESO-1 antibodies were detected in all BPH patients tested. The present study has demonstrated the expression of NY-ESO-1mRNA in prostate Cancer patients and NY-ESO-1 antibody production. Our data suggest that NY-ESO-1 could be used as a tumor marker and constitute a good candidate for vaccine-based immunotherapy for hormonal resistant prostate cancer patients.

  10. Vaccination with NY-ESO-1 overlapping peptides mixed with Picibanil OK-432 and montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen.

    Science.gov (United States)

    Wada, Hisashi; Isobe, Midori; Kakimi, Kazuhiro; Mizote, Yu; Eikawa, Shingo; Sato, Eiichi; Takigawa, Nagio; Kiura, Katsuyuki; Tsuji, Kazuhide; Iwatsuki, Keiji; Yamasaki, Makoto; Miyata, Hiroshi; Matsushita, Hirokazu; Udono, Heiichiro; Seto, Yasuyuki; Yamada, Kazuhiro; Nishikawa, Hiroyoshi; Pan, Linda; Venhaus, Ralph; Oka, Mikio; Doki, Yuichiro; Nakayama, Eiichi

    2014-01-01

    We conducted a clinical trial of an NY-ESO-1 cancer vaccine using 4 synthetic overlapping long peptides (OLP; peptides #1, 79-108; #2, 100-129; #3, 121-150; and #4, 142-173) that include a highly immunogenic region of the NY-ESO-1 molecule. Nine patients were immunized with 0.25 mg each of three 30-mer and a 32-mer long NY-ESO-1 OLP mixed with 0.2 KE Picibanil OK-432 and 1.25 mL Montanide ISA-51. The primary endpoints of this study were safety and NY-ESO-1 immune responses. Five to 18 injections of the NY-ESO-1 OLP vaccine were well tolerated. Vaccine-related adverse events observed were fever and injection site reaction (grade 1 and 2). Two patients showed stable disease after vaccination. An NY-ESO-1-specific humoral immune response was observed in all patients and an antibody against peptide #3 (121-150) was detected firstly and strongly after vaccination. NY-ESO-1 CD4 and CD8 T-cell responses were elicited in these patients and their epitopes were identified. Using a multifunctional cytokine assay, the number of single or double cytokine-producing cells was increased in NY-ESO-1-specific CD4 and CD8 T cells after vaccination. Multiple cytokine-producing cells were observed in PD-1 (-) and PD-1 (+) CD4 T cells. In conclusion, our study indicated that the NY-ESO-1 OLP vaccine mixed with Picibanil OK-432 and Montanide ISA-51 was well tolerated and elicited NY-ESO-1-specific humoral and CD4 and CD8 T-cell responses in immunized patients.

  11. Linking Hunter Knowledge with Forest Change to Understand Changing Deer Harvest Opportunities in Intensively Logged Landscapes

    Directory of Open Access Journals (Sweden)

    Todd J. Brinkman

    2009-06-01

    Full Text Available The effects of landscape changes caused by intensive logging on the availability of wild game are important when the harvest of wild game is a critical cultural practice, food source, and recreational activity. We assessed the influence of extensive industrial logging on the availability of wild game by drawing on local knowledge and ecological science to evaluate the relationship between forest change and opportunities to harvest Sitka black-tailed deer (Odocoileus hemionus sitkensis on Prince of Wales Island, Alaska. We used data collected through interviews with local deer hunters and GIS analysis of land cover to determine relationships among landscape change, hunter access, and habitat for deer hunting over the last 50 yr. We then used these relationships to predict how harvest opportunities may change in the future. Intensive logging from 1950 into the 1990s provided better access to deer and habitat that facilitated deer hunting. However, successional changes in intensively logged forests in combination with a decline in current logging activity have reduced access to deer and increased undesirable habitat for deer hunting. In this new landscape, harvest opportunities in previously logged landscapes have declined, and hunters identify second-growth forest as one of the least popular habitats for hunting. Given the current state of the logging industry in Alaska, it is unlikely that the logging of the remaining old-growth forests or intensive management of second-growth forests will cause hunter opportunities to rebound to historic levels. Instead, hunter opportunities may continue to decline for at least another human generation, even if the long-term impacts of logging activity and deer harvest on deer numbers are minimal. Adapting hunting strategies to focus on naturally open habitats such as alpine and muskeg that are less influenced by external market forces may require considerably more hunting effort but provide the best option for

  12. 33 CFR 110.87 - Henderson Harbor, N.Y.

    Science.gov (United States)

    2010-07-01

    ... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.87 Henderson Harbor, N.Y. (a) Area A. The area in the... latitude 43°51′08.8″ N, longitude 76°12′08.9″ W, thence to latitude 43°51′09.0″ N, longitude 76°12′19.0″ W, thence to latitude 43°51′33.4″ N, longitude 76°12′19.0″ W, thence to latitude 43°51′33.4″ N, longitude...

  13. NY-ESO-1 — EDRN Public Portal

    Science.gov (United States)

    NY-ESO-1, official name CTAG1B, is an antigen that is expressed in normal testis and ovary and overexpressed in a wide variety of cancers. The CTAG1B gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. CTAG1B is expressed from 18 weeks until birth in human fetal testis. In the adult testis, is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells (at protein level).

  14. Increased NY-ESO-1 Expression and Reduced Infiltrating CD3+ T Cells in Cutaneous Melanoma

    OpenAIRE

    Mara Giavina-Bianchi; Pedro Giavina-Bianchi; Mirian Nacagami Sotto; Alona Muzikansky; Jorge Kalil; Cyro Festa-Neto; Duncan, Lyn M.

    2015-01-01

    NY-ESO-1 is a cancer-testis antigen aberrantly expressed in melanomas, which may serve as a robust and specific target in immunotherapy. NY-ESO-1 antigen expression, tumor features, and the immune profile of tumor infiltrating lymphocytes were assessed in primary cutaneous melanoma. NY-ESO-1 protein was detected in 20% of invasive melanomas (16/79), rarely in in situ melanoma (1/10) and not in benign nevi (0/20). Marked intratumoral heterogeneity of NY-ESO-1 protein expression was observed. N...

  15. Increased NY-ESO-1 Expression and Reduced Infiltrating CD3+ T Cells in Cutaneous Melanoma

    Directory of Open Access Journals (Sweden)

    Mara Giavina-Bianchi

    2015-01-01

    Full Text Available NY-ESO-1 is a cancer-testis antigen aberrantly expressed in melanomas, which may serve as a robust and specific target in immunotherapy. NY-ESO-1 antigen expression, tumor features, and the immune profile of tumor infiltrating lymphocytes were assessed in primary cutaneous melanoma. NY-ESO-1 protein was detected in 20% of invasive melanomas (16/79, rarely in in situ melanoma (1/10 and not in benign nevi (0/20. Marked intratumoral heterogeneity of NY-ESO-1 protein expression was observed. NY-ESO-1 expression was associated with increased primary tumor thickness (P=0.007 and inversely correlated with superficial spreading melanoma (P<0.02. NY-ESO-1 expression was also associated with reduced numbers and density of CD3+ tumor infiltrating lymphocytes (P=0.017. When NY-ESO-1 protein was expressed, CD3+ T cells were less diffusely infiltrating the tumor and were more often arranged in small clusters (P=0.010 or as isolated cells (P=0.002 than in large clusters of more than five lymphocytes. No correlation of NY-ESO-1 expression with gender, age, tumor site, ulceration, lymph node sentinel status, or survival was observed. NY-ESO-1 expression in melanoma was associated with tumor progression, including increased tumor thickness, and with reduced tumor infiltrating lymphocytes.

  16. NY-ESO-1 protein glycosylated by yeast induces enhanced immune responses.

    Science.gov (United States)

    Wadle, Andreas; Mischo, Axel; Strahl, Sabine; Nishikawa, Hiroyoshi; Held, Gerhard; Neumann, Frank; Wullner, Beate; Fischer, Eliane; Kleber, Sascha; Karbach, Julia; Jager, Elke; Shiku, Hiroshi; Odunsi, Kunle; Shrikant, Protul A; Knuth, Alexander; Cerundolo, Vincenzo; Renner, Christoph

    2010-11-01

    Vaccine strategies that target dendritic cells to elicit potent cellular immunity are the subject of intense research. Here we report that the genetically engineered yeast Saccharomyces cerevisiae, expressing the full-length tumour-associated antigen NY-ESO-1, is a versatile host for protein production. Exposing dendritic cells (DCs) to soluble NY-ESO-1 protein linked to the yeast a-agglutinin 2 protein (Aga2p) protein resulted in protein uptake, processing and MHC class I cross-presentation of NY-ESO-1-derived peptides. The process of antigen uptake and cross-presentation was dependent on the glycosylation pattern of NY-ESO-1-Aga2p protein and the presence of accessible mannose receptors. In addition, NY-ESO-1-Aga2p protein uptake by dendritic cells resulted in recognition by HLA-DP4 NY-ESO-1-specific CD4(+) T cells, indicating MHC class II presentation. Finally, vaccination of mice with yeast-derived NY-ESO-1-Aga2p protein led to an enhanced humoral and cellular immune response, when compared to the bacterially expressed NY-ESO-1 protein. Together, these data demonstrate that yeast-derived full-length NY-ESO-1-Aga2p protein is processed and presented efficiently by MHC class I and II complexes and warrants clinical trials to determine the potential value of S. cerevisiae as a host for cancer vaccine development. Copyright © 2010 John Wiley & Sons, Ltd.

  17. Fish species and other data from DERWENT HUNTER from 31 August 1959 to 16 June 1960 (NODC Accession 7300634)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — In September 1959 the cruise programme for F.R.V. DERWENT HUNTER was changed and cruises were planned to investigate tuna in South-East Australian waters in a much...

  18. NY-ESO-1 expression in synovial sarcoma and other mesenchymal tumors: significance for NY-ESO-1-based targeted therapy and differential diagnosis.

    Science.gov (United States)

    Lai, Jin-Ping; Robbins, Paul F; Raffeld, Mark; Aung, Phyu Phyu; Tsokos, Maria; Rosenberg, Steven A; Miettinen, Markku M; Lee, Chyi-Chia Richard

    2012-06-01

    A promising targeted therapy against NY-ESO-1 (CTAG 1B) using genetically modified T-cells in synovial sarcomas was recently demonstrated in a clinical trial at the NCI. To investigate the role of NY-ESO-1 immunohistochemistry in patient selection and gain better insight into the incidence of NY-ESO-1 expression in synovial sarcomas and other mesenchymal tumors, we evaluated NY-ESO-1 expression by immunohistochemistry in 417 tumors. This collection of samples included: 50 SS18/SSX1/2 fusion positive synovial sarcomas, 155 gastrointestinal stromal tumors (GIST), 135 other spindle cell sarcomas as well as 77 other sarcomas (chondrosarcoma, osteosarcoma, dedifferentiated liposarcoma, alveolar soft part sarcoma, rhabdomyosarcoma, angiosarcoma, malignant mesothelioma, and Ewing's sarcoma). We report that 76% of synovial sarcomas expressed NY-ESO-1 in a strong and diffuse pattern (2-3+, >50-70% of tumor cells). In contrast, only rare cases of other spindle cell mesenchymal tumor expressed NY-ESO-1 (GIST (2/155), malignant peripheral nerve sheath tumors (1/34), and dermatofibrosarcoma protuberans (2/20)). Individual cases of other sarcomas (angiosarcoma, malignant mesothelioma, chondrosarcoma, osteosarcoma, dedifferentiated liposarcoma, alveolar soft part sarcoma, and Ewing's sarcoma) were positive for NY-ESO-1. However, no positive cases were identified amongst our cohort of leiomyosarcomas (0/24), hemangiopericytoma/solitary fibrous tumors (0/40), and cellular schwannomas (0/17). In summary, we find that NY-ESO-1 is strongly and diffusely expressed in a majority of synovial sarcomas, but only rarely in other mesenchymal lesions. Beyond its role in patient selection for targeted therapy, immunohistochemistry for NY-ESO-1 may be diagnostically useful for the distinction of synovial sarcoma from other spindle cell neoplasms.

  19. Human behavior. Sex equality can explain the unique social structure of hunter-gatherer bands.

    Science.gov (United States)

    Dyble, M; Salali, G D; Chaudhary, N; Page, A; Smith, D; Thompson, J; Vinicius, L; Mace, R; Migliano, A B

    2015-05-15

    The social organization of mobile hunter-gatherers has several derived features, including low within-camp relatedness and fluid meta-groups. Although these features have been proposed to have provided the selective context for the evolution of human hypercooperation and cumulative culture, how such a distinctive social system may have emerged remains unclear. We present an agent-based model suggesting that, even if all individuals in a community seek to live with as many kin as possible, within-camp relatedness is reduced if men and women have equal influence in selecting camp members. Our model closely approximates observed patterns of co-residence among Agta and Mbendjele BaYaka hunter-gatherers. Our results suggest that pair-bonding and increased sex egalitarianism in human evolutionary history may have had a transformative effect on human social organization. Copyright © 2015, American Association for the Advancement of Science.

  20. Beyond the Cut Hunter: A Historical Epidemiology of HIV Beginnings in Central Africa.

    Science.gov (United States)

    Rupp, Stephanie; Ambata, Philippe; Narat, Victor; Giles-Vernick, Tamara

    2016-12-01

    In the absence of direct evidence, an imagined "cut hunter" stands in for the index patient of pandemic HIV/AIDS. During the early years of colonial rule, this explanation goes, a hunter was cut or injured from hunting or butchering a chimpanzee infected with simian immunodeficiency virus, resulting in the first sustained human infection with the virus that would emerge as HIV-1M. We argue here that the "cut hunter" relies on a historical misunderstanding and ecological oversimplification of human-chimpanzee (Pan Troglodytes troglodytes) interactions that facilitated pathogenic transmission. This initial host shift cannot explain the beginnings of the HIV/AIDS pandemic. Instead, we must understand the processes by which the virus became transmissible, possibly between Sangha basin inhabitants and ultimately reached Kinshasa. A historical epidemiology of the late nineteenth and twentieth centuries, provides a much-needed corrective to the major shortcomings of the cut hunter. Based on 62 oral historical interviews conducted in southeastern Cameroon and archival research, we show that HIV emerged from ecological, economic, and socio-political transformations of the late nineteenth and twentieth centuries. The gradual imposition of colonial rule built on and reoriented ecologies and economies, and altered older patterns of mobility and sociality. Certain changes may have contributed to the initial viral host shift, but more importantly, facilitated the adaptation of HIV-1M to human-to-human transmission. Our evidence suggests that the most critical changes occurred after 1920. This argument has important implications for public health policy, underscoring recent work emphasizing alternative pathways for zoonotic spillovers into human beings.

  1. A Philatelic Excursion with Jeff Hunter in Probability and Matrix Theory

    Directory of Open Access Journals (Sweden)

    George P. H. Styan

    2007-01-01

    Full Text Available We present an excursion with Jeff Hunter, visiting some of his research topics. Specifically, we will present some facts about certain people whose work seems to have influenced Jeff in his scientific career; we illustrate our presentation with postage stamps that have been issued in honour of these people. Our main guide is Hunter’s two-volume book entitled Mathematical Techniques of Applied Probability (Academic Press, 1983.

  2. Newborn screening for hunter disease: a small-scale feasibility study.

    Science.gov (United States)

    Ruijter, G J G; Goudriaan, D A; Boer, A M; Van den Bosch, J; Van der Ploeg, A T; Elvers, L H; Weinreich, S S; Reuser, A J

    2014-01-01

    Hunter disease (Mucopolysaccharidosis type II, MPS II) is an X-linked lysosomal storage disorder caused by deficiency of iduronate-2-sulfatase (IDS). Two main therapies have been reported for MPS II patients: enzyme-replacement therapy (ERT) and hematopoietic stem-cell transplantation (HSCT). Both treatment modalities have been shown to improve some symptoms, but the results with regard to cognitive functioning have been poor. Early initiation of therapy, i.e., before neurological symptoms have manifested, may alter cognitive outcome. The need for early identification makes Hunter disease a candidate for newborn screening (NBS). Our objective was to explore the use of a fluorometric assay that could be applicable for high-throughput analysis of IDS activity in dried blood spots (DBS). The median IDS activity in DBS samples from 1,426 newborns was 377 pmol/punch/17 h (range 78-1111). The IDS activity in one sample was repeatedly under the cutoff value (set at 20% of the median value), which would imply a recall rate of 0.07%. A sample from a clinically diagnosed MPS II individual, included in each 96-well test plate, had IDS activities well below the 20% cutoff value. Coefficients of variation in quality control samples with low, medium, and high IDS activities (190, 304, and 430 pmol/punch/17 h, respectively) were 12% to 16%. This small-scale pilot study shows that newborn screening for Hunter disease using a fluorometric assay in DBS is technically feasible with a fairly low recall rate. NBS may allow for identification of infants with Hunter disease before clinical symptoms become evident enabling early intervention.

  3. Shell beads of the Last Hunter-Gatherers and Earliest Farmers in South-Western Europe

    Directory of Open Access Journals (Sweden)

    Álvarez-Fernández, E.

    2010-01-01

    Full Text Available This paper analyses the suspended objects of adornment made from marine mollusc shells that have been recorded at Mesolithic and Neolithic sites in southwest Europe. Particular attention will be given to taxonomic determination, technological aspects and the strategies utilised to obtain the raw materials for these objects. The distribution of certain species and the types of ornamentation used by the last hunter-gatherers and first farming communities will also be discussed.

  4. 演奏八弦吉他的怪才Charlie Hunter

    Institute of Scientific and Technical Information of China (English)

    石岩

    2002-01-01

      一看到这把怪琴,少见的8弦配置加上扇形的弦品指板,你就会知道使用这把吉他的吉他手一定是个怪才.他就是Charlie Hunter,一个富于创新的年轻爵士吉他手.……

  5. Atmospheric Research in Ny-Aalesund. Proceedings from the Third NySMAC meeting. NILU, Kjeller, Norway, 9.-11. April 1997

    Energy Technology Data Exchange (ETDEWEB)

    Floeisand, Inga; Gernandt, Hartwig; Larsen, Elisabeth Stoltz; Stordal, Frode; Wada, Makoto

    1997-07-01

    Leading abstract. The Ny-Aalesund Seminar Series was conceived by NySMAC (Ny-Aalesund Science Managers Committee) as a means of bringing together research scientists involved in programmes running at Ny-Aalesund or having an interest in that area. The first Seminar was held in Potsdam in Germany in May 1995, and included talks which covered all current research disciplines; physical, atmospheric, earth and biological sciences. The Second Seminar was devoted to biological science and particularly to ecology. It was held in Cambridge in UK in February 1996. The subject of this Third Seminar, held in Kjeller in Norway in April 1997, is atmospheric research in Ny-Aalesund. Since the early 1980s a wide range of projects have been carried out on Svalbard and particularly at Ny-Aalesund. Prominent in this research have been several international research programmes with emphasis on topics of e.g. Arctic (Arctic Monitoring and Assessment Programme, AMAP), European (European Monitoring and Evaluation Programme, EMEP) or global (International Geosphere-Biosphere Programme, IGBP; World Climate Research Programme, WCRP) scales. Atmospheric observations have been carried out in Ny-Aalesund in Svalbard for several years. From the early 1980s, the long range transport of sulphur dioxide and sulphate aerosols leading to Arctic Haze, has been studied. As a consequence, EMEP included Ny-Aalesund in their network. In the following years the transport of ozone and chemical precursors were observed, and recently the naturally occurring phenomenon of rapid surface ozone loss has been given particular attention. From the late 1980s observations of the stratospheric ozone layer and related chemical species were undertaken, and the efforts have increased considerably since. Ny-Aalesund is now one of the primary Arctic sites of the NDSC (Network for Detection of Stratospheric Change) network. Important efforts have been undertaken to participate in the European campaigns as the European

  6. Guidelines for diagnosis and treatment of Hunter Syndrome for clinicians in Latin America

    Science.gov (United States)

    Giugliani, Roberto; Villarreal, Martha Luz Solano; Valdez, C. Araceli Arellano; Hawilou, Antonieta Mahfoud; Guelbert, Norberto; Garzón, Luz Norela Correa; Martins, Ana Maria; Acosta, Angelina; Cabello, Juan Francisco; Lemes, Aída; Santos, Mara Lucia Schmitz Ferreira; Amartino, Hernán

    2014-01-01

    This review aims to provide clinicians in Latin America with the most current information on the clinical aspects, diagnosis, and management of Hunter syndrome, a serious and progressive disease for which specific treatment is available. Hunter syndrome is a genetic disorder where iduronate-2-sulfatase (I2S), an enzyme that degrades glycosaminoglycans, is absent or deficient. Clinical manifestations vary widely in severity and involve multiple organs and tissues. An attenuated and a severe phenotype are recognized depending on the degree of cognitive impairment. Early diagnosis is vital for disease management. Clinical signs common to children with Hunter syndrome include inguinal hernia, frequent ear and respiratory infections, facial dysmorphisms, macrocephaly, bone dysplasia, short stature, sleep apnea, and behavior problems. Diagnosis is based on screening urinary glycosaminoglycans and confirmation by measuring I2S activity and analyzing I2S gene mutations. Idursulfase (recombinant I2S) (Elaprase®, Shire) enzyme replacement therapy (ERT), designed to address the underlying enzyme deficiency, is approved treatment and improves walking capacity and respiratory function, and reduces spleen and liver size and urinary glycosaminoglycan levels. Additional measures, responding to the multi-organ manifestations, such as abdominal/inguinal hernia repair, carpal tunnel surgery, and cardiac valve replacement, should also be considered. Investigational treatment options such as intrathecal ERT are active areas of research, and bone marrow transplantation is in clinical practice. Communication among care providers, social workers, patients and families is essential to inform and guide their decisions, establish realistic expectations, and assess patients’ responses. PMID:25071396

  7. Guidelines for diagnosis and treatment of Hunter Syndrome for clinicians in Latin America

    Directory of Open Access Journals (Sweden)

    Roberto Giugliani

    2014-06-01

    Full Text Available This review aims to provide clinicians in Latin America with the most current information on the clinical aspects, diagnosis, and management of Hunter syndrome, a serious and progressive disease for which specific treatment is available. Hunter syndrome is a genetic disorder where iduronate-2-sulfatase (I2S, an enzyme that degrades glycosaminoglycans, is absent or deficient. Clinical manifestations vary widely in severity and involve multiple organs and tissues. An attenuated and a severe phenotype are recognized depending on the degree of cognitive impairment. Early diagnosis is vital for disease management. Clinical signs common to children with Hunter syndrome include inguinal hernia, frequent ear and respiratory infections, facial dysmorphisms, macrocephaly, bone dysplasia, short stature, sleep apnea, and behavior problems. Diagnosis is based on screening urinary glycosaminoglycans and confirmation by measuring I2S activity and analyzing I2S gene mutations. Idursulfase (recombinant I2S (Elaprase®, Shire enzyme replacement therapy (ERT, designed to address the underlying enzyme deficiency, is approved treatment and improves walking capacity and respiratory function, and reduces spleen and liver size and urinary glycosaminoglycan levels. Additional measures, responding to the multi-organ manifestations, such as abdominal/inguinal hernia repair, carpal tunnel surgery, and cardiac valve replacement, should also be considered. Investigational treatment options such as intrathecal ERT are active areas of research, and bone marrow transplantation is in clinical practice. Communication among care providers, social workers, patients and families is essential to inform and guide their decisions, establish realistic expectations, and assess patients' responses.

  8. Indigenous knowledge of medicinal plants among Dozo hunters: an ethnobotanical survey in Niamberla village, Burkina Faso.

    Science.gov (United States)

    Tibiri, André; Sawadogo, Wamtinga Richard; Dao, Abou; Elkington, Bethany G; Ouedraogo, Noufou; Guissou, Innocent Pierre

    2015-05-01

    This investigation aims to provide a database of Dozo traditional knowledge of medicinal plants used for the treatment of common diseases. The study was conducted through individual interviews using a survey form. Data were recorded in a database allowing statistical analysis. Each plant was recorded and documented with a herbarium specimen. Settings/Location & Subjects: The term Dozo refers to great hunters from Burkina Faso, highly renowned for their knowledge of medicinal plants. Niamberla village was founded by Dozo hunters and is currently the residence of many traditional healers. Unfortunately, their indigenous knowledge is not well recorded and may be lost between two generations. A total of 16 traditional healers were interviewed, giving 89 recipes for the treatment of 37 diseases. The most common diseases are malaria (13%), psychological/spiritual issues (12%), gastric disorders (11%), sexually transmitted diseases (10%), and wounds (8%). A total of 56 medicinal plants have been identified, consisting mostly of trees (44%), shrubs (34%), and herbs (16%). The results of this research provide a basis for pharmacological and toxicological investigations and are necessary to preserve the indigenous knowledge of traditional medicine among Dozo hunters.

  9. Looking at the Camp: Paleolithic Depiction of a Hunter-Gatherer Campsite.

    Directory of Open Access Journals (Sweden)

    Marcos García-Diez

    Full Text Available Landscapes and features of the everyday world were scarcely represented in Paleolithic art, especially those features associated with the human landscape (huts and campsites. On the contrary, other figurative motifs (especially animals and signs, traditionally linked to the magic or religious conceptions of these hunter-gatherer societies, are the predominant themes of Upper Paleolithic art. This paper seeks to present an engraved schist slab recently found in the Molí del Salt site (North-eastern Iberia and dated at the end of the Upper Paleolithic, ca. 13,800 years ago. This slab displays seven semicircular motifs that may be interpreted as the representation of dome-shaped huts. The analysis of individual motifs and the composition, as well as the ethnographic and archeological contextualization, suggests that this engraving is a naturalistic depiction of a hunter-gatherer campsite. Campsites can be considered the first human landscape, the first area of land whose visible features were entirely constructed by humans. Given the social meaning of campsites in hunter-gatherer life-styles, this engraving may be considered one of the first representations of the domestic and social space of a human group.

  10. Looking at the Camp: Paleolithic Depiction of a Hunter-Gatherer Campsite.

    Science.gov (United States)

    García-Diez, Marcos; Vaquero, Manuel

    2015-01-01

    Landscapes and features of the everyday world were scarcely represented in Paleolithic art, especially those features associated with the human landscape (huts and campsites). On the contrary, other figurative motifs (especially animals) and signs, traditionally linked to the magic or religious conceptions of these hunter-gatherer societies, are the predominant themes of Upper Paleolithic art. This paper seeks to present an engraved schist slab recently found in the Molí del Salt site (North-eastern Iberia) and dated at the end of the Upper Paleolithic, ca. 13,800 years ago. This slab displays seven semicircular motifs that may be interpreted as the representation of dome-shaped huts. The analysis of individual motifs and the composition, as well as the ethnographic and archeological contextualization, suggests that this engraving is a naturalistic depiction of a hunter-gatherer campsite. Campsites can be considered the first human landscape, the first area of land whose visible features were entirely constructed by humans. Given the social meaning of campsites in hunter-gatherer life-styles, this engraving may be considered one of the first representations of the domestic and social space of a human group.

  11. Estimating occupancy and predicting numbers of gray wolf packs in Montana using hunter surveys

    Science.gov (United States)

    Rich, Lindsey N.; Russell, Robin E.; Glenn, Elizabeth M.; Mitchell, Michael S.; Gude, Justin A.; Podruzny, Kevin M.; Sime, Carolyn A.; Laudon, Kent; Ausband, David E.; Nichols, James D.

    2013-01-01

    Reliable knowledge of the status and trend of carnivore populations is critical to their conservation and management. Methods for monitoring carnivores, however, are challenging to conduct across large spatial scales. In the Northern Rocky Mountains, wildlife managers need a time- and cost-efficient method for monitoring gray wolf (Canis lupus) populations. Montana Fish, Wildlife and Parks (MFWP) conducts annual telephone surveys of >50,000 deer and elk hunters. We explored how survey data on hunters' sightings of wolves could be used to estimate the occupancy and distribution of wolf packs and predict their abundance in Montana for 2007–2009. We assessed model utility by comparing our predictions to MFWP minimum known number of wolf packs. We minimized false positive detections by identifying a patch as occupied if 2–25 wolves were detected by ≥3 hunters. Overall, estimates of the occupancy and distribution of wolf packs were generally consistent with known distributions. Our predictions of the total area occupied increased from 2007 to 2009 and predicted numbers of wolf packs were approximately 1.34–1.46 times the MFWP minimum counts for each year of the survey. Our results indicate that multi-season occupancy models based on public sightings can be used to monitor populations and changes in the spatial distribution of territorial carnivores across large areas where alternative methods may be limited by personnel, time, accessibility, and budget constraints.

  12. Migratory bird hunter opinions regarding potential management strategies for controlling light goose populations

    Science.gov (United States)

    Dinges, Andrew J.; Webb, Elisabeth B.; Vrtiska, Mark P.; Nilon, Charles H.; Wilhelm Stanis, Sonja A.

    2014-01-01

    We expanded the Nebraska Light Goose Conservation Order (LGCO) harvest survey (NE, USA) in spring 2012 to assess migratory bird hunter opinions regarding future management strategies for controlling light goose populations. Although hunters strongly agreed that population control of light geese was an important wildlife management issue, they were generally unsupportive of wildlife officials using forms of direct control methods to control light goose populations. Respondents who indicated participation in the 2012 LGCO were also less supportive of any form of direct control compared with migratory bird hunters who did not participate in the LGCO. When presented with alternative methods by wildlife officials for future light goose population control, respondents were most supportive of wildlife agencies selectively shooting light geese on migration and wintering areas and least supportive of wildlife officials using bait with approved chemicals to euthanize light geese. A clear understanding of public perception of various potential direct-control options will likely assist wildlife biologists in making informed decisions on how to proceed with population control of light geese.

  13. Neuraminidase subtyping of avian influenza viruses with PrimerHunter-designed primers and quadruplicate primer pools.

    Science.gov (United States)

    Huang, Yanyan; Khan, Mazhar I; Khan, Mazhar; Măndoiu, Ion; Măndoiu, Ion I

    2013-01-01

    We have previously developed a software package called PrimerHunter to design primers for PCR-based virus subtyping. In this study, 9 pairs of primers were designed with PrimerHunter and successfully used to differentiate the 9 neuraminidase (NA) genes of avian influenza viruses (AIVs) in multiple PCR-based assays. Furthermore, primer pools were designed and successfully used to decrease the number of reactions needed for NA subtyping from 9 to 4. The quadruplicate primer-pool method is cost-saving, and was shown to be suitable for the NA subtyping of both cultured AIVs and uncultured AIV swab samples. The primers selected for this study showed excellent sensitivity and specificity in NA subtyping by RT-PCR, SYBR green-based Real-time PCR and Real-time RT-PCR methods. AIV RNA of 2 to 200 copies (varied by NA subtypes) could be detected by these reactions. No unspecific amplification was displayed when detecting RNAs of other avian infectious viruses such as Infectious bronchitis virus, Infectious bursal disease virus and Newcastle disease virus. In summary, this study introduced several sensitive and specific PCR-based assays for NA subtyping of AIVs and also validated again the effectiveness of the PrimerHunter tool for the design of subtyping primers.

  14. Multimodal image analysis of the retina in Hunter syndrome (mucopolysaccharidosis type II): Case report.

    Science.gov (United States)

    Salvucci, Isadora Darriba Macedo; Finzi, Simone; Oyamada, Maria Kiyoko; Kim, Chong Ae; Pimentel, Sérgio Luis Gianotti

    2017-08-18

    We report a case of retinal and posterior ocular findings in a 33-year-old man diagnosed with Hunter syndrome (Mucopolysaccharidosis type II) in a multimodal imaging way. Our patient was complaining of blurred night vision for the past 3 years. He had not received any systemic treatment for Hunter syndrome. Vision acuity was 20/20 in both eyes and corneas were clear. Fundus examination revealed bilateral crowded and hyperemic optic nerve heads (elevated in the ocular ultrasound) and areas of subretinal hypopigmentation. There was hyperautofluorescence at the central fovea and perifovea, and a diffuse bilateral choroidal fluorescence in angiography. Macular SD-OCT showed a thinning of the external retina at the perifovea in both eyes. Visual field testing showed a bilateral ring scotoma. The full field ERG was subnormal, with a negative response in the scotopic phase. Visual Evoked Potencial test and cranial MRI were normal. Our multimodal analysis reported here attempted to contribute to the knowledge of the natural history of GAG deposition in the eye, focusing on the retina and retinal pigment epithelium. Defining this natural history is essential for a proper comparison with Hunter patients receiving systemic treatment, thus determining if it can or cannot improve retinal function in humans with this disorder.

  15. Effects of changing sea ice on marine mammals and subsistence hunters in northern Alaska from traditional knowledge interviews.

    Science.gov (United States)

    Huntington, Henry P; Quakenbush, Lori T; Nelson, Mark

    2016-08-01

    Marine mammals are important sources of food for indigenous residents of northern Alaska. Changing sea ice patterns affect the animals themselves as well as access to them by hunters. Documenting the traditional knowledge of Iñupiaq and Yupik hunters concerning marine mammals and sea ice makes accessible a wide range of information relevant to understanding the ecosystem to which humans belong. We interviewed hunters in 11 coastal villages from the northern Bering Sea to the Beaufort Sea. Hunters reported extensive changes in sea ice and weather that have affected the timing of marine mammal migrations, their distribution and behaviour and the efficacy of certain hunting methods. Amidst these changes, however, hunters cited offsetting technological benefits, such as more powerful and fuel-efficient outboard engines. Other concerns included potential impacts to subsistence hunting from industrial activity such as shipping and oil and gas development. While hunters have been able to adjust to some changes, continued environmental changes and increased disturbance from human activity may further challenge their ability to acquire food in the future. There are indications, however, that innovation and flexibility provide sources of resilience.

  16. Nonlocal Symmetries and Geometric Integrability of Multi-Component Camassa-Holm and Hunter-Saxton Systems

    Institute of Scientific and Technical Information of China (English)

    YAN Lu; SONG Jun-Feng; QU Chang-Zheng

    2011-01-01

    We present the multi-component Hunter-Saxton and μ-Camassa-Holm systems. It is shown that the multicomponent Camassa-Holm, Hunter-Saxton and μ-Camassa-Holm systems are geometrically integrable, namely they describe pseudo-spherical surfaces. As a consequence, their infinite number of conservation laws can be directly constructed. For the three-component Camo ssa-Holm and Hunter-Saxton systems, their nonlocal symmetries depending on the pseudo-potentials are obtained.%@@ We present the multi-component Hunter-Saxton and μ-Camassa-Holm systems.It is shown that the multicomponent Camassa-Holm,Hunter-Saxton and μ-Camassa-Holm systems are geometrically integrable,namely they describe pseudo-spherical surfaces.As a consequence,their infinite number of conservation laws can be directly constructed.For the three-component Camassa-Holm and Hunter-Saxton systems,their nonlocal symmetries depending on the pseudo-potentials are obtained.

  17. NY-ESO-1 expression predicts an aggressive phenotype of ovarian cancer.

    Science.gov (United States)

    Szender, J Brian; Papanicolau-Sengos, Antonios; Eng, Kevin H; Miliotto, Anthony J; Lugade, Amit A; Gnjatic, Sacha; Matsuzaki, Junko; Morrison, Carl D; Odunsi, Kunle

    2017-06-01

    NY-ESO-1 is a cancer testis antigen and a promising target for immunotherapy. The purpose of this study was to determine the expression frequency, immunogenicity, and clinical impact of NY-ESO-1 in ovarian cancer. Immunohistochemistry (IHC), reverse-transcription polymerase chain reaction (RT-PCR), and quantitative-PCR (qRT-PCR) were utilized in an ovarian cancer (including Fallopian tube and primary peritoneal cancers) patient cohort; humoral responses against NY-ESO-1 were determined by ELISA. Clinicopathologic outcomes including progression-free (PFS) and overall (OS) survival were evaluated based on NY-ESO-1 expression. Cohen's kappa (κ) tested agreement between expression tests. NY-ESO-1 expression was detected by any method in 40.7% of 1002 patients' tumors (NY-ESO-1+) and baseline humoral response was identified in 19.0% of 689 tested patients. NY-ESO-1+ patients were older (pESO-1+ patients. A subset analysis of NY-ESO-1+ patients that received immunotherapy demonstrated improved OS by >2years (52.6 vs. 27.2months, pESO-1 expression and an aggressive cancer phenotype. The relatively high expression frequency of NY-ESO-1 in ovarian cancer patients coupled with the poor clinical outcomes in NY-ESO-1+ patients reveals an underappreciated need for targeted therapy against this antigen. In support, our study reveals that NY-ESO-1+ patients enrolled on immunotherapy trials targeting the antigen exhibited an improvement in OS. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Archive of Datasonics SIS-1000 Chirp Subbottom Data Collected During USGS Cruise DIAN 96040 Long Island, NY Inner Shelf -- Fire Island, NY, 4-24 September, 1996

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This CD-ROM contains digital high resolution seismic reflection data collected during the USGS DIAN 96040 cruise. The coverage is the nearshore of Long Island, NY in...

  19. Archive of Datasonics SIS-1000 Chirp Subbottom Data Collected During USGS Cruise DIAN 96040 Long Island, NY Inner Shelf -- Fire Island, NY, 4-24 September, 1996

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This CD-ROM contains digital high resolution seismic reflection data collected during the USGS DIAN 96040 cruise. The coverage is the nearshore of Long Island, NY in...

  20. NOAA Office for Coastal Management Benthic Habitat Data, Long Island Sound, Jamaica Bay, and Lower Bay of NY/NJ Harbor, NY, 1994-2002 (NODC Accession 0089467)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data are a collection of benthic habitat data from studies conducted in the coastal Long Island Sound, NY region in GIS shapefile (.shp, .dbf, .shx, and .prj...

  1. NY-ESO-1抗原与肿瘤免疫治疗进展%NY-ESO-1 and Cancer Immunotherapy

    Institute of Scientific and Technical Information of China (English)

    彭吉润; 冷希圣

    2008-01-01

    NY-ESO-1抗原是肿瘤-睾丸抗原家族中的重要成员,在多种类型的肿瘤中广泛表达,并且是迄今发现的最具免疫原性的肿瘤抗原,可以在NY-ESO-1表达阳性的肿瘤患者体内引起自发性体液免疫反应和特异性T细胞免疫反应.因此,NY-ESO-1被认为是最好的肿瘤候选疫苗,在肿瘤免疫治疗中最具发展潜力.本文主要介绍了近年来有关NY-ESO-1抗原以及相关疫苗的研究进展.

  2. Progress in NY-ESO-I as cancer vaccines%NY-ESO-1癌症疫苗研究进展

    Institute of Scientific and Technical Information of China (English)

    刘志青

    2006-01-01

    NY-ESO-1抗原是近年来发现的一种肿瘤特异性抗原,在乳腺癌、黑色素瘤、食管癌等20多种肿瘤中均有不同程度的表达.NY-ESO-1的广泛表达使其成为多种实体瘤特异性疫苗免疫治疗的首选抗原.在制备NY-ESO-1癌症疫苗时,目前主要围绕癌症疫苗的类型、抗原的加工提呈两个方面进行研究.现综述近年来NY-ESO-1癌症疫苗在这两方面的研究进展.

  3. Archive of Datasonics SIS-1000 Chirp Subbottom Data Collected During USGS Cruise DIAN 96040 Long Island, NY Inner Shelf -- Fire Island, NY, 4-24 September, 1996

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This CD-ROM contains digital high resolution seismic reflection data collected during the USGS DIAN 96040 cruise. The coverage is the nearshore of Long Island, NY...

  4. Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient.

    Science.gov (United States)

    Tsuji, Kazuhide; Hamada, Toshitada; Uenaka, Akiko; Wada, Hisashi; Sato, Eiichi; Isobe, Midori; Asagoe, Kenji; Yamasaki, Osamu; Shiku, Hiroshi; Ritter, Gerd; Murphy, Roger; Hoffman, Eric W; Old, Lloyd J; Nakayama, Eiichi; Iwatsuki, Keiji

    2008-10-01

    NY-ESO-1 is a cancer/testis antigen highly immunogenic in cancer patients. Cholesterol-bearing hydrophobized pullulan (CHP) is a nanoparticle-forming antigen-delivery vehicle and CHP complexed with NY-ESO-1 protein (CHP-NY-ESO-1) efficiently activates CD4 and CD8 T cells in vitro. In this study we report on a 50-year-old male melanoma patient with multiple skin and organ metastases (T4N3M1c) who was vaccinated with CHP-NY-ESO-1 at biweekly intervals and who had an unusual disease course. We characterized in this patient humoral and cellular immune responses, immune regulatory cells, and cytokine profiles in the peripheral blood and at local tumor sites. Ten days after the second CHP-NY-ESO-1 vaccination (day 25), blisters appeared on the skin at the metastatic lesions associated with inflammatory changes. A skin biopsy showed the presence of many NY-ESO-1-expressing apoptotic melanoma cells as determined by a terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) test. However, the tumors continued to grow, and the patient died of pulmonary failure due to multiple metastases on day 48. Serum antibody responses were detected after the second CHP-NY-ESO-1 vaccination and antibody titer increased with subsequent vaccinations. Th1 dependent IgG1 was the predominant immunoglobulin subtype. Both, NY-ESO-1-specific CD4 and CD8 T cell responses were detected in PBMC by IFN-gamma secretion assays. After CHP-NY-ESO-1 vaccination a slight decrease in CD4(+)CD25(+)Foxp3(+) Tregs was observed in PBMC but significantly increased numbers of CD4(+)CD25(+)Foxp3(+) Tregs and CD68(+) immunoregulatory macrophages were detected at the local tumor sites. CD4(+)CD25(+)Foxp3(+) Tregs were also increased in the blister fluid. Cytokines in the serum suggested a polarization towards a Th1 pattern in the PBMC and those in the blister fluid suggested a Th2-type response at the tumor site. Our observations indicate induction of specific humoral and

  5. Wind-blown sand movement periods on the Nyírség alluvial fan, Hungary

    Science.gov (United States)

    Buró, Botond; Lóki, József; Sipos, György; Négyesi, Gábor; Andrási, Bence; Jakab, Attila; Félegyházi, Enikő; Molnár, Mihály

    2017-04-01

    Wind-blown sand movement periods on the Nyírség alluvial fan, Hungary The Nyírség is an alluvial fan, was built by rivers, which were flown down from the NE Carpathians. When the weather was dry, wind-blown sand was blowed out and the wind started to develop the aeolian landforms. The first significant sand movements in the Nyírség was in the Upper plenniglacial and the Late glacial. The main landforms of the Nyírség were developed at this time. The aeolic transformation of the land was not completed in the Nyírség at the end of the Pleistocene. In the Holocene the sand moved within small area, mainly by anthropogenic impact. Our aim is clarify the age of the wind-blown sand movements period, with different absolute (Radiocarbon dating method, OSL), and relative (Archaeological finds, Pollen analyses) dating methods. We have collected for the age determining charcoal from many sand quarry (Gégény, Kántorjánosi, Nyíradony, Nagyvarsány, Máriapócs and Lövőpetri) which contain fossil soil layer. For the OSL measurements samples were collected from Baktalórántháza, Gégény and Kántorjánosi sand quarries. We collected samples from 5 places for the pollen analyses (Nyírtanya, Máriapócs, Nyírbéltek-Nyírlúgos, Nyírábrány, Vámospércs), and also from an archaeological excavation (Nyíregyháza- Oros). The new age dates show us, that in the Nyírség the first significant sand movements were in the cold and drier period of the Upper pleniglacial and Late glacial (Baktalórántháza, Nyírtanya, Vámospércs). At the end of the Pleistocene the sand movements not competed in the Nyírség (Gégény, Kántorjánosi, Nyírábrány). In the Holocene there were many little sand movement periods, mainly caused by anthropogenic impact (Nyíradony, Nyíregyháza-Oros). The research was supported by the European Union and the State of Hungary, co-financed by the European Regional Development Fund in the project of GINOP-2.3.2.-15-2016-00009 'ICER

  6. 33 CFR 110.150 - Block Island Sound, N.Y.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Block Island Sound, N.Y. 110.150 Section 110.150 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.150 Block Island Sound, N.Y. (a) The anchorage ground. A...

  7. 33 CFR 110.85 - Niagara River, Youngstown, N.Y.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Niagara River, Youngstown, N.Y. 110.85 Section 110.85 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.85 Niagara River, Youngstown, N.Y. (a) Area...

  8. 78 FR 35596 - Special Local Regulation; Long Beach Regatta, Powerboat Race, Atlantic Ocean, Long Beach, NY

    Science.gov (United States)

    2013-06-13

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulation; Long Beach Regatta, Powerboat Race, Atlantic Ocean, Long Beach, NY AGENCY: Coast Guard, DHS. ACTION: Notice of Proposed Rulemaking... Atlantic Ocean off Long Beach, NY during the Long Beach Regatta Powerboat Race scheduled for August...

  9. Epigenetic potentiation of NY-ESO-1 vaccine therapy in human ovarian cancer.

    Science.gov (United States)

    Odunsi, Kunle; Matsuzaki, Junko; James, Smitha R; Mhawech-Fauceglia, Paulette; Tsuji, Takemasa; Miller, Austin; Zhang, Wa; Akers, Stacey N; Griffiths, Elizabeth A; Miliotto, Anthony; Beck, Amy; Batt, Carl A; Ritter, Gerd; Lele, Shashikant; Gnjatic, Sacha; Karpf, Adam R

    2014-01-01

    The cancer-testis/cancer-germline antigen NY-ESO-1 is a vaccine target in epithelial ovarian cancer (EOC), but its limited expression is a barrier to vaccine efficacy. As NY-ESO-1 is regulated by DNA methylation, we hypothesized that DNA methyltransferase (DNMT) inhibitors may augment NY-ESO-1 vaccine therapy. In agreement, global DNA hypomethylation in EOC was associated with the presence of circulating antibodies to NY-ESO-1. Pre-clinical studies using EOC cell lines showed that decitabine treatment enhanced both NY-ESO-1 expression and NY-ESO-1-specific CTL-mediated responses. Based on these observations, we performed a phase I dose-escalation trial of decitabine, as an addition to NY-ESO-1 vaccine and doxorubicin liposome (doxorubicin) chemotherapy, in 12 patients with relapsed EOC. The regimen was safe, with limited and clinically manageable toxicities. Both global and promoter-specific DNA hypomethylation occurred in blood and circulating DNAs, the latter of which may reflect tumor cell responses. Increased NY-ESO-1 serum antibodies and T cell responses were observed in the majority of patients, and antibody spreading to additional tumor antigens was also observed. Finally, disease stabilization or partial clinical response occurred in 6/10 evaluable patients. Based on these encouraging results, evaluation of similar combinatorial chemo-immunotherapy regimens in EOC and other tumor types is warranted.

  10. Expression and immunogenicity of NY-ESO-1 in colorectal cancer.

    Science.gov (United States)

    Li, Ya; Song, Ruifeng; Li, Xinqiang; Xu, Feng

    2017-06-01

    Serum assays of NY-ESO-1 antibodies provide a guide to discriminate between patients who suffer from different types of cancer. In the present study, the expression of NY-ESO-1 was detected with the aim to identify a novel tumor antigen in colorectal cancer (CRC). Sera were obtained from 89 healthy individuals and 236 patients with CRC with stage I, II, III and IV tumors. The NY-ESO-1 autoantibody levels were determined using an enzyme-linked immunosorbent assay. The mRNA and protein expression levels of NY-ESO-1 were detected using reverse transcription-polymerase chain reaction and immunohistochemistry, respectively, in 60 CRC and paired adjacent non-tumor tissues. NY-ESO-1 antibody was detected in 40 of the 236 (16.9%) patients with CRC. The NY-ESO-1 antibody combined with carcinoembryonic antigen enhanced the sensitivity, from 52.1 to 62.7%, of the diagnosis of CRC. The frequency of antibody positivity increased with the TNM cancer stage (8.8 vs. 28.3% in stages I+II and III+IV, respectively). The mRNA and protein expression levels of NY-ESO-1 were significantly higher in CRC tissue than in adjacent non-tumor tissue. In conclusion, NY-ESO-1 is frequently expressed in CRC with the capacity of inducing a humoral immune response in CRC patients, exhibiting the potential to be a promising biomarker for CRC.

  11. Increased NY-ESO-1 expression and reduced infiltrating CD3+ T cells in cutaneous melanoma.

    Science.gov (United States)

    Giavina-Bianchi, Mara; Giavina-Bianchi, Pedro; Sotto, Mirian Nacagami; Muzikansky, Alona; Kalil, Jorge; Festa-Neto, Cyro; Duncan, Lyn M

    2015-01-01

    NY-ESO-1 is a cancer-testis antigen aberrantly expressed in melanomas, which may serve as a robust and specific target in immunotherapy. NY-ESO-1 antigen expression, tumor features, and the immune profile of tumor infiltrating lymphocytes were assessed in primary cutaneous melanoma. NY-ESO-1 protein was detected in 20% of invasive melanomas (16/79), rarely in in situ melanoma (1/10) and not in benign nevi (0/20). Marked intratumoral heterogeneity of NY-ESO-1 protein expression was observed. NY-ESO-1 expression was associated with increased primary tumor thickness (P = 0.007) and inversely correlated with superficial spreading melanoma (P ESO-1 expression was also associated with reduced numbers and density of CD3+ tumor infiltrating lymphocytes (P = 0.017). When NY-ESO-1 protein was expressed, CD3+ T cells were less diffusely infiltrating the tumor and were more often arranged in small clusters (P = 0.010) or as isolated cells (P = 0.002) than in large clusters of more than five lymphocytes. No correlation of NY-ESO-1 expression with gender, age, tumor site, ulceration, lymph node sentinel status, or survival was observed. NY-ESO-1 expression in melanoma was associated with tumor progression, including increased tumor thickness, and with reduced tumor infiltrating lymphocytes.

  12. NY-ESO-1-specific immunological pressure and escape in a patient with metastatic melanoma.

    Science.gov (United States)

    von Boehmer, Lotta; Mattle, Muriel; Bode, Peter; Landshammer, Alexandro; Schäfer, Carolin; Nuber, Natko; Ritter, Gerd; Old, Lloyd; Moch, Holger; Schäfer, Niklaus; Jäger, Elke; Knuth, Alexander; van den Broek, Maries

    2013-01-01

    During cancer progression, malignant cells may evade immunosurveillance. However, evidence for immunological escape in humans is scarce. We report here the clinical course of a melanoma patient whose initial tumor was positive for the antigens NY-ESO-1, MAGE-C1, and Melan-A. Upon immunization with a recombinant vaccinia/fowlpox NY-ESO-1 construct, the patient experienced a mixed clinical response and spreading of the NY-ESO-1 epitopes in the CD4+ T cell compartment. After NY-ESO-1 protein + CpG immunization, the patient's anti-NY-ESO-1 IgG response increased. Over the following years, progressing lesions were resected and found to be NY-ESO-1-negative while being positive for MAGE-C1, Melan-A, and MHC-I. The fatal, inoperable brain metastasis was analyzed after his death and also proved to be NY-ESO-1-negative, while being positive for MAGE-C1 and Melan-A, as well as MHC-I. We propose that cancer control and cancer escape in this patient were governed by NY-ESO-1-specific immunological pressure. Our findings provide evidence for the existence of immunoediting and immunoescape in this cancer patient.

  13. 75 FR 38710 - Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY

    Science.gov (United States)

    2010-07-06

    ... Championships, Huntington Bay, NY'' in the Federal Register (75 FR 13454). The Coast Guard received no comments...-2009-0520) in the Federal Register (74 FR 51243). The notice proposed a regulated area encompassing 100... Bay, NY in the Federal Register (75 FR 13454). This notice proposes a 100 yard regulated area...

  14. 77 FR 35113 - Canadian National Railway Company-Abandonment Exemption-in Niagara County, NY

    Science.gov (United States)

    2012-06-12

    ... milepost 0.20 to approximately milepost 0.35 in the City of Niagara Falls, Niagara County, N.Y., a distance... track in Niagara Falls, extending between the eastern end of the Bridge and the beginning of the Niagara... Niagara Falls, N.Y., and Niagara Falls, Ontario, Canada, and is owned by the bi-national Niagara......

  15. 33 CFR 165.170 - Safety Zone: Triathlon, Ulster Landing, Hudson River, NY.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone: Triathlon, Ulster Landing, Hudson River, NY. 165.170 Section 165.170 Navigation and Navigable Waters COAST GUARD, DEPARTMENT... § 165.170 Safety Zone: Triathlon, Ulster Landing, Hudson River, NY. (a) Regulated area. The...

  16. 77 FR 30451 - Safety Zone; Olcott Fireworks, Lake Ontario, Olcott, NY

    Science.gov (United States)

    2012-05-23

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Olcott Fireworks, Lake Ontario, Olcott, NY... establish a temporary safety zone on Lake Ontario, Olcott, NY. This proposed rule is intended to restrict vessels from a portion of Lake Ontario during the Olcott fireworks display. The safety zone established...

  17. Site Formation Processes and Hunter-Gatherers Use of Space in a Tropical Environment: A Geo-Ethnoarchaeological Approach from South India

    OpenAIRE

    Friesem, David E.; Lavi, Noa; Madella, Marco; Ajithprasad, P; French, C

    2016-01-01

    Hunter-gatherer societies have distinct social perceptions and practices which are expressed in unique use of space and material deposition patterns. However, the identification of archaeological evidence associated with hunter-gatherer activity is often challenging, especially in tropical environments such as rainforests. We present an integrated study combining ethnoarchaeology and geoarchaeology in order to study archaeological site formation processes related to hunter-gatherers’ ways of ...

  18. Bacterial Diversity of Ny-Ålesund, Arctic Archipelago Svalbard

    Directory of Open Access Journals (Sweden)

    Battsetseg Choidash

    2012-12-01

    Full Text Available The bacterial diversity of the water sample, collected from Ny-Ålesund, Arctic Archipelago Svalbard was analyzed by a phenotypic as well as a genotypic approach. Pure colonies of the culturable bacteria were established and grown at a range of temperatures: 4ºC, 15ºC, 22ºC and 37ºC. Optimum growth was found at 15ºC, and around 28 colonies were obtained. The library was dominated by 16S rDNAs of Gram-negative bacteria ( γ -Proteobacteria. Twenty two isolates exhibited sequences were similar to that of known bacterial isolates (>97% sequence similarity, represented by the species of the genera Psychrobacter , Pseudomonas , and Acinetobacter . Six isolates exhibited sequences showed less affi liation with known taxa (<97% sequence similarity, and may represent novel taxa.

  19. Using obsidian transfer distances to explore social network maintenance in late Pleistocene hunter-gatherers.

    Science.gov (United States)

    Pearce, Eiluned; Moutsiou, Theodora

    2014-12-01

    Social behaviour is notoriously difficult to study archaeologically and it is unclear how large the networks of prehistoric humans were, or how they remained connected. Maintaining social cohesion was crucial for early humans because social networks facilitate cooperation and are imperative for survival and reproduction. Recent hunter-gatherer social organisation typically comprises a number of nested layers, ranging from the nuclear family through to the ~1500-strong ethnolinguistic tribe. Here we compare maximum obsidian transfer distances from the late Pleistocene with ethnographic data on the size of the geographic areas associated with each of these social grouping layers in recent hunter-gatherers. The closest match between the two is taken to indicate the maximum social layer within which contact could be sustained by Pleistocene hominins. Within both the (sub)tropical African and Subarctic biomes, the maximum obsidian transfer distances for Pleistocene modern humans (~200km and ~400km respectively) correspond to the geographic ranges of the outermost tribal layer in recent hunter-gatherers. This suggests that modern humans could potentially sustain the cohesion of their entire tribe at all latitudes, even though networks are more dispersed nearer the poles. Neanderthal obsidian transfer distances (300km) indicate that although Neanderthal home ranges are larger than those of low latitude hominins, Neanderthals travelled shorter distances than modern humans living at the same high latitudes. We argue that, like modern humans, Neanderthals could have maintained tribal cohesion, but that their tribes were substantially smaller than those of contemporary modern humans living in similar environments. The greater time taken to traverse the larger modern human tribal ranges may have limited the frequency of their face-to-face interactions and thus necessitated additional mechanisms to ensure network connectivity, such as the exchange of symbolic artefacts

  20. Settlement-Size Scaling among Prehistoric Hunter-Gatherer Settlement Systems in the New World.

    Science.gov (United States)

    Haas, W Randall; Klink, Cynthia J; Maggard, Greg J; Aldenderfer, Mark S

    2015-01-01

    Settlement size predicts extreme variation in the rates and magnitudes of many social and ecological processes in human societies. Yet, the factors that drive human settlement-size variation remain poorly understood. Size variation among economically integrated settlements tends to be heavy tailed such that the smallest settlements are extremely common and the largest settlements extremely large and rare. The upper tail of this size distribution is often formalized mathematically as a power-law function. Explanations for this scaling structure in human settlement systems tend to emphasize complex socioeconomic processes including agriculture, manufacturing, and warfare-behaviors that tend to differentially nucleate and disperse populations hierarchically among settlements. But, the degree to which heavy-tailed settlement-size variation requires such complex behaviors remains unclear. By examining the settlement patterns of eight prehistoric New World hunter-gatherer settlement systems spanning three distinct environmental contexts, this analysis explores the degree to which heavy-tailed settlement-size scaling depends on the aforementioned socioeconomic complexities. Surprisingly, the analysis finds that power-law models offer plausible and parsimonious statistical descriptions of prehistoric hunter-gatherer settlement-size variation. This finding reveals that incipient forms of hierarchical settlement structure may have preceded socioeconomic complexity in human societies and points to a need for additional research to explicate how mobile foragers came to exhibit settlement patterns that are more commonly associated with hierarchical organization. We propose that hunter-gatherer mobility with preferential attachment to previously occupied locations may account for the observed structure in site-size variation.

  1. Bartonella henselae infection in a family experiencing neurological and neurocognitive abnormalities after woodlouse hunter spider bites

    Science.gov (United States)

    2013-01-01

    Background Bartonella species comprise a group of zoonotic pathogens that are usually acquired by vector transmission or by animal bites or scratches. Methods PCR targeting the Bartonella 16S-23S intergenic spacer (ITS) region was used in conjunction with BAPGM (Bartonella alpha Proteobacteria growth medium) enrichment blood culture to determine the infection status of the family members and to amplify DNA from spiders and woodlice. Antibody titers to B. vinsonii subsp. berkhoffii (Bvb) genotypes I-III, B. henselae (Bh) and B. koehlerae (Bk) were determined using an IFA test. Management of the medical problems reported by these patients was provided by their respective physicians. Results In this investigation, immediately prior to the onset of symptoms two children in a family experienced puncture-like skin lesions after exposure to and presumptive bites from woodlouse hunter spiders. Shortly thereafter, the mother and both children developed hive-like lesions. Over the ensuing months, the youngest son was diagnosed with Guillain-Barre (GBS) syndrome followed by Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). The older son developed intermittent disorientation and irritability, and the mother experienced fatigue, headaches, joint pain and memory loss. When tested approximately three years after the woodlouse hunter spider infestation, all three family members were Bartonella henselae seroreactive and B. henselae DNA was amplified and sequenced from blood, serum or Bartonella alpha-proteobacteria (BAPGM) enrichment blood cultures from the mother and oldest son. Also, B. henselae DNA was PCR amplified and sequenced from a woodlouse and from woodlouse hunter spiders collected adjacent to the family’s home. Conclusions Although it was not possible to determine whether the family’s B. henselae infections were acquired by spider bites or whether the spiders and woodlice were merely accidental hosts, physicians should consider the possibility that B

  2. Thoracolumbar kyphoscoliosis with unilateral subluxation of the spine and postoperative lumbar spondylolisthesis in Hunter syndrome.

    Science.gov (United States)

    Roberts, Simon B; Tsirikos, Athanasios I

    2016-03-01

    Surgical correction for kyphoscoliosis is increasingly being performed for patients with mucopolysaccharidosis (MPS). Reported case series have predominantly included patients with Type I (Hurler) and Type IV (Morquio) MPS. To their knowledge, the authors describe the first case report of surgical management of thoracolumbar kyphoscoliosis in Hunter syndrome (MPS Type II) and the rare occurrence of lumbar spondylolisthesis following surgical stabilization. A 12-year-old boy with Hunter syndrome presented with severe thoracolumbar kyphoscoliosis and no associated symptoms. Spinal radiographs demonstrated kyphosis of 48° (T11-L3) and scoliosis of 22° (T11-L3) with an anteriorly hypoplastic L-1 vertebra. The deformity progressed to kyphosis of 60° and scoliosis of 42° prior to surgical intervention. Spinal CT scans identified left T12-L1 facet subluxation, causing anterior rotatory displacement of the spine proximal to L-1 and bilateral L-5 isthmic spondylolysis with no spondylolisthesis. A combined single-stage anterior and posterior instrumented spinal arthrodesis from T-9 to L-4 was performed. Kyphosis and scoliosis were corrected to 4° and 0°, respectively. Prolonged ventilator support and nasogastric feedings were required for 3 months postoperatively. At 2.5 years following surgery, the patient was asymptomatic, mobilizing independently, and had achieved a solid spinal fusion. However, he had also developed a Grade II spondylolisthesis at L4-5; this was managed nonoperatively in the absence of symptoms or further deterioration of the spondylolisthesis to the 3.5-year postoperative follow-up visit. Satisfactory correction of thoracolumbar kyphoscoliosis in Hunter syndrome can be achieved by combined anterior/posterior instrumented arthrodesis. The risk of developing deformity or instability in motion segments adjacent to an instrumented fusion may be greater in patients with MPS related to the underlying connective tissue disorder.

  3. Settlement-Size Scaling among Prehistoric Hunter-Gatherer Settlement Systems in the New World.

    Directory of Open Access Journals (Sweden)

    W Randall Haas

    Full Text Available Settlement size predicts extreme variation in the rates and magnitudes of many social and ecological processes in human societies. Yet, the factors that drive human settlement-size variation remain poorly understood. Size variation among economically integrated settlements tends to be heavy tailed such that the smallest settlements are extremely common and the largest settlements extremely large and rare. The upper tail of this size distribution is often formalized mathematically as a power-law function. Explanations for this scaling structure in human settlement systems tend to emphasize complex socioeconomic processes including agriculture, manufacturing, and warfare-behaviors that tend to differentially nucleate and disperse populations hierarchically among settlements. But, the degree to which heavy-tailed settlement-size variation requires such complex behaviors remains unclear. By examining the settlement patterns of eight prehistoric New World hunter-gatherer settlement systems spanning three distinct environmental contexts, this analysis explores the degree to which heavy-tailed settlement-size scaling depends on the aforementioned socioeconomic complexities. Surprisingly, the analysis finds that power-law models offer plausible and parsimonious statistical descriptions of prehistoric hunter-gatherer settlement-size variation. This finding reveals that incipient forms of hierarchical settlement structure may have preceded socioeconomic complexity in human societies and points to a need for additional research to explicate how mobile foragers came to exhibit settlement patterns that are more commonly associated with hierarchical organization. We propose that hunter-gatherer mobility with preferential attachment to previously occupied locations may account for the observed structure in site-size variation.

  4. Effect of Piper chaba Hunter, Piper sarmentosum Roxb. and Piper interruptum Opiz. on natural killer cell activity and lymphocyte proliferation.

    Science.gov (United States)

    Panthong, Sumalee; Itharat, Arunporn

    2014-08-01

    Immune system is the most important system ofhuman body. Thaifolk doctors have used some medicinal plants as an adaptogenic drug or immunomodulatory agent. Piper chaba Hunter, Piper sarmentosum Roxb. and Piper interruptum Opiz. are used by folk doctors to activate immune response in cancer patients. To investigate the effect on natural killer cell activity and on lymphocyte proliferation activity of water extract of P chaba Hunter P. sarmentosum Roxb. and P interruptum Opiz. MATERIAL ANDMETHOD: Plant materials were extracted by decoction method. All extracts were testedfor an immunomodulatory effect using PBMCs from twelve healthy donors by chromium release assay. Lymphocyte proliferation was also determined by 3H-thymidine uptake assay. The degree of activation was expressed as the stimulation index. The water extract of P chaba Hunter significantly increased lymphocyte proliferation at concentrations ofl ng/ml, 10 ng/ml, 1 μg/ml, 5 μg/ml, 10 μg/ml and 100 μg/ml. P sarmentosum Roxb., and P interruptum Opiz. extracts at those concentrations significantly stimulated lymphocyteproliferation. P sarmentosum Roxb. extractsignificantly increased natural killer (NK) cell activity at a concentration of 100 μg/ml but P chaba Hunter and P interruptum Opiz. extracts did not significantly stimulate natural killer cell activity. P chaba Hunter, P interruptum Opiz. andP sarmentosum Roxb. have an immunomodulatory effect especially for P sarmentosum Roxb. extract which can activate both lymphocyte proliferation and NK cell activity.

  5. Increased incidence of neonatal respiratory distress in infants with mucopolysaccharidosis type II (MPS II, Hunter syndrome).

    Science.gov (United States)

    Dodsworth, Charlotte; Burton, Barbara K

    2014-02-01

    Records were reviewed on all patients with mucopolysaccharidosis type II (Hunter syndrome) seen at a single institution from 1999 to 2013 to identify those with a history of neonatal intensive care. Eleven of 34 patients were in a neonatal intensive care unit and all had respiratory distress with 8 diagnoses of respiratory distress syndrome and 3 of transient tachypnea of the newborn. None of the infants were premature; four were delivered by cesarean section. These findings suggest that respiratory distress is more commonly observed in neonates with MPS II than in the general population. This may reflect airway disease already present in this disorder at the time of birth.

  6. Environmental injustice and air pollution in coal affected communities, Hunter Valley, Australia.

    Science.gov (United States)

    Higginbotham, Nick; Freeman, Sonia; Connor, Linda; Albrecht, Glenn

    2010-03-01

    The authors describe environmental injustice from air pollution in the Upper Hunter, Australia, and analyse the inaction of state authorities in addressing residents' health concerns. Obstacles blocking a public-requested health study and air monitoring include: the interdependence of state government and corporations in reaping the economic benefits of coal production; lack of political will, regulatory inertia and procedural injustice; and study design and measurement issues. We analyse mining- and coal-related air pollution in a contested socio-political arena, where residents, civil society and local government groups struggle with corporations and state government over the burden of imposed health risk caused by air pollution.

  7. Period Determination of Asteroid Targets Observed at Hunters Hill Observatory: May 2009 - September 2010

    Science.gov (United States)

    Higgins, David

    2011-01-01

    Lightcurves for 27 asteroids were obtained at the Hunters Hill Observatory (HHO) from 2009 May through 2010 September: 308 Polyxo, 326 Tamara, 369 Aeria, 504 Cora, 822 Lalage, 1164 Kobolda, 1619 Ueta, 1625 The NORC, 1685 Toro, 2189 Zaragoza, 2287 Kalmykia, 2639 Planman, 3695 Fiaia, 4786 Tatianina, 5333 Kanaya, (5452) 1937 NN, 6170 Levasseur, 7741 Fedoseev, 14815 Rutberg, 15724 Zille, 16525 Shumarinaiko, (21996) 1993 XP31, (29729) 1999 BY1, (35404) 1997 YV5, (39087) 2000 VN50, (66146) 1998 TU3, and (101769) 1999 FF52.

  8. 王邪斗争新体验之HUNTER THE RECKONING

    Institute of Scientific and Technical Information of China (English)

    暴龙

    2002-01-01

    《猎手(Hunter)》是High Voltage Software公司很早就推出的一款游戏,原作曾经赢得了很多玩者的赞赏,但是它的续作《猎手:测算(Hunter: The Reckoning)》的制作更加精细。在游戏中,当选择了4个“猎手”之一后,你会切身体会到在黑暗的宇宙中同邪恶进行斗争的艰辛。

  9. Consideration on the Survival and Loneliness in the Heart Is a Lonely Hunter

    Institute of Scientific and Technical Information of China (English)

    Li LI

    2015-01-01

    "Loneliness" is the main melody in almost all the works of Carson McCullers, and it is particularly prominent in novel the Heart Is a Lonely Hunter. All characters in the works were confined by loneliness and could not extricate themselves. Why do human beings feel so lonely?In this paper, the root of the loneliness reflected by human survival itself is discussed, namely, the relationship between the inherent conflict and loneliness of human survival, so as to think about loneliness deeply.

  10. Environmental injustice and air pollution in coal affected communities, Hunter Valley, Australia

    Energy Technology Data Exchange (ETDEWEB)

    Higginbotham, N.; Freeman, S.; Connor, L.; Albrecht, G. [University of Newcastle, Callaghan, NSW (Australia). School of Medicine & Public Health

    2010-03-15

    The authors describe environmental injustice from air pollution in the Upper Hunter, Australia, and analyse the inaction of state authorities in addressing residents' health concerns. Obstacles blocking a public-requested health study and air monitoring include: the interdependence of state government and corporations in reaping the economic benefits of coal production; lack of political will, regulatory inertia and procedural injustice; and study design and measurement issues. We analyse mining- and coal-related air pollution in a contested socio-political arena, where residents, civil society and local government groups struggle with corporations and state government over the burden of imposed health risk caused by air pollution.

  11. T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma.

    Science.gov (United States)

    Singh, Nathan; Kulikovskaya, Irina; Barrett, David M; Binder-Scholl, Gwendolyn; Jakobsen, Bent; Martinez, Daniel; Pawel, Bruce; June, Carl H; Kalos, Michael D; Grupp, Stephan A

    The cancer-testis antigen NY-ESO-1 is expressed by many solid tumors and has limited expression by mature somatic tissues, making it a highly attractive target for tumor immunotherapy. Targeting NY-ESO-1 using engineered T cells has demonstrated clinical efficacy in the treatment of some adult tumors. Neuroblastoma is a significant cause of cancer mortality in children, and is a tumor type shown to be responsive to immunotherapies. We evaluated a large panel of primarily resected neuroblastoma samples and demonstrated that 23% express NY-ESO-1. After confirming antigen-specific activity of T cells genetically engineered to express an NY-ESO-1 directed high-affinity transgenic T cell receptor in vitro, we performed xenograft mouse studies assessing the efficacy of NY-ESO-1-targeted T cells in both localized and disseminated models of neuroblastoma. Disease responses were monitored by tumor volume measurement and in vivo bioluminescence. After delivery of NY-ESO-1 transgenic TCR T cells, we observed significant delay of tumor progression in mice bearing localized and disseminated neuroblastoma, as well as enhanced animal survival. These data demonstrate that NY-ESO-1 is an antigen target in neuroblastoma and that targeted T cells represent a potential therapeutic option for patients with neuroblastoma.

  12. Expression of MAGE-A and NY-ESO-1 in Primary and Metastatic Cancers.

    Science.gov (United States)

    Park, Tristen S; Groh, Eric M; Patel, Krishna; Kerkar, Sid P; Lee, Chyi-Chia Richard; Rosenberg, Steven A

    2016-01-01

    Melanoma-associated antigen-A (MAGE-A) and New York esophageal squamous cell cancer-1 (NY-ESO-1) are 2 cancer testis antigens (CTA) demonstrating potential for use in targeted immunotherapy. Clinical trials in melanoma and synovial sarcomas targeting these antigens in immune-based therapies have demonstrated durable tumor regression. Although protein expression of NY-ESO-1 has been assessed in a variety of cancer types, the expression of MAGE-A has not been studied in depth. In this study we analyzed MAGE-A and NY-ESO-1 expression in 314 melanoma specimens from 301 melanoma patients, 38 patients with squamous cell cancers and 111 patients with adenocarcinomas. Our results demonstrated higher expression of MAGE-A compared with NY-ESO-1 in melanomas (32% vs. 13%) and squamous cell carcinomas (45% vs. 7.9%), and higher expression of both CTAs in metastatic versus primary tumors. CTA expression in adenocarcinomas was low (MAGE-A: 10%, NY-ESO-1: 0.9%). In addition, we looked at concordance of expression among metastatic melanoma lesions within the same patient and found concordant expression in 38 of 47 patients for MAGE-A and 43 of 47 patients for NY-ESO-1. Our study demonstrated that the MAGE-A family may be of greater utility than NY-ESO-1 for targeted immunotherapy in a variety of cancer histologies, in particular metastatic melanomas and squamous cell carcinomas.

  13. Expression of NY-ESO-1 ,NY-SAR-35 in retinoblastoma and its clinical significance%视网膜母细胞瘤中NY-ESO-1、NY-SAR-35基因的表达及其临床意义

    Institute of Scientific and Technical Information of China (English)

    严宇清; 林泉; 孔旻; 何剑峰; 陈迎迎; 谢小薰; 罗彬; 梁皓

    2012-01-01

    背景 视网膜母细胞瘤(RB)的免疫治疗因创伤小、针对性强而受到广泛关注,寻求相关免疫原性较强的肿瘤抗原是免疫治疗的基础.NY-ESO-I和NY-SAR-35是癌-睾丸抗原(CTA)中的两种基因,检测其在RB组织中的表达可为RB的免疫治疗研究提供依据. 目的 研究RB中NY-ESO-1 mRNA、NY-SAR-35 mRNA的表达情况,探讨将其用于RB特异性免疫治疗靶抗原的可能性. 方法 收集15例RB患儿组织为RB组、12例非肿瘤病变部位视网膜组织为非肿瘤病变组,及22例眼部因其他眼部病变进行手术治疗获取的正常相关眼组织标本为正常组.采用逆转录聚合酶链反应(RT-PCR)检测待测组织标本中NY-ESO-1mRNA、NY-SAR-35 mRNA的表达;并按随机数字表法抽取RT-PCR检测的阳性产物直接进行DNA测序,对检测结果与肿瘤病理分级、肿瘤大小、临床分期等临床指标进行分析.结果 15例RB组织中有6例标本表达NY-ESO-1基因,9例标本表达NY-SAR-35基因;在12例非肿瘤病变视网膜组织及22例眼部正常组织中均未见到NY-ESO-1基因和NY-SAR-35基因的表达.NY-ESO-1基因和NY-SAR-35基因的表达均与患者的性别(P=0.426、0.822)、年龄(P=0.180、0.464)、病理分型(P=0.744、0.582)、肿瘤大小(P=0.760、0.790)、临床分期(P=0.868、0.707)等临床相关指标无明显关联.结论 NY-ESO-1基因及NY-SAR-35基因均可特异性地高表达于RB组织中,其表达率明显高于其他全身肿瘤,有可能成为RB特异性免疫治疗的靶抗原.%Background The immunotherapy for retinoblastoma(RB) is gradually concerned recent year.To seek relative immune-associated antigen is a basis of immunotherapy.NY-ESO-1 and NY-SAR-35 are two kinds of genes of cancer testis antigen( CTA ).To understand their expressions in RB tissue can offer index for relative study.Objective This study was to investigate the expressions of two CTA NY-ESO-1 and NY-SAR-35 in RB and explore the possibility of them as

  14. A novel human-derived antibody against NY-ESO-1 improves the efficacy of chemotherapy.

    Science.gov (United States)

    Gupta, Anurag; Nuber, Natko; Esslinger, Christoph; Wittenbrink, Mareike; Treder, Martin; Landshammer, Alexandro; Noguchi, Takuro; Kelly, Marcus; Gnjatic, Sacha; Ritter, Erika; von Boehmer, Lotta; Nishikawa, Hiroyoshi; Shiku, Hiroshi; Old, Lloyd; Ritter, Gerd; Knuth, Alexander; van den Broek, Maries

    2013-01-01

    We investigated whether antibodies against intracellular tumor-associated antigens support tumor-specific immunity when administered together with a treatment that destroys the tumor. We propose that released antigens form immune complexes with the antibodies, which are then efficiently taken up by dendritic cells. We cloned the first human monoclonal antibodies against the Cancer/Testis (CT) antigen, NY-ESO-1. We tested whether the monoclonal anti-NY-ESO-1 antibody (12D7) facilitates cross-presentation of a NY-ESO-1-derived epitope by dendritic cells to human CD8+ T cells, and whether this results in the maturation of dendritic cells in vitro. We investigated the efficacy of 12D7 in combination with chemotherapy using BALB/c mice bearing syngeneic CT26 tumors that express intracellular NY-ESO-1. Human dendritic cells that were incubated with NY-ESO-1:12D7 immune complexes efficiently stimulated NY-ESO-1(157-165)/HLA-A2-specific human CD8+ T cells to produce interferon-γ, whereas NY-ESO-1 alone did not. Furthermore, the incubation of dendritic cells with NY-ESO-1:12D7 immune complexes resulted in the maturation of dendritic cells. Treatment of BALB/c mice that bear CT26/NY-ESO-1 tumors with 5-fluorouracil (5-FU) plus 12D7 was significantly more effective than chemotherapy alone. We propose systemic injection of monoclonal antibodies (mAbs) against tumor-associated antigens plus a treatment that promotes the local release of those antigens resulting in immune complex formation as a novel therapeutic modality for cancer.

  15. Application of serum NY-ESO-1 antibody assay for early SCLC diagnosis.

    Science.gov (United States)

    Yang, Jihua; Jiao, Shunchang; Kang, Jingbo; Li, Rong; Zhang, Guanzhong

    2015-01-01

    NY-ESO-1 antibody is one of the cancer-related antibodies. The purpose of this study was to investigate the diagnostic role of the NY-ESO-1 humoral immune response in small cell lung cancer (SCLC). We recombined the recombinant protein of NY-ESO-1 antibody and NSE, analyzed them by Enzyme-linked immunosorbent assay, and then established the Receiver Operating Characteristic (ROC) curve to estimate the diagnostic value of NY-ESO-1 antibody, NSE and their combinations. According to detection, the positive rate of NY-ESO-1 humoral immune response (26.3%), NSE (43.8%) and their combinations (10.5%) were all lower than the negative rate which indicated that the NY-ESO-1 antibody might be down-regulated in SCLC. And the positive rate wasn't related to clinicopathologic characteristics. The ROC curve demonstrated that with a 37.17% sensitivity and a 91.7% specificity along with a AUC of 0.619 for NY-ESO-1ab as well as with a 48.3% sensitivity and a 90.87% specificity along with a AUC value of 0.773 for NSE, their diagnostic value were both high. Besides, the diagnostic value of their combinations was also good for a AUC of 0.83 and a 69.12% sensitivity and a 91.8% specificity. There were significant difference of diagnostic value among three types above (NY-ESO-1 vs. NSE, P ESO-1, P ESO-1ab, NSE and their combinations all were important diagnostic markers for SCLC. Moreover, the diagnostic value of their combinations was higher than any single of them. And NY-ESO-1 humoral immune to NSE might be a potential diagnostic indicator in SCLC.

  16. Expression of NY-ESO-1 gene in human hepatocellular carcinoma%人类NY-ESO-1基因编码在肝癌中的表达

    Institute of Scientific and Technical Information of China (English)

    张阳德; 任菲; 彭健

    2013-01-01

    目的 研究NY-ESO-1在肝细胞肝癌中的表达情况并探索其表达与肝癌预后的相关性.方法 我们收集了124例肝癌患者的肝癌组织和相应的癌旁组织,37例肝硬化患者的肝组织,以及43例非肝硬化的肝组织.应用实时荧光定量聚合酶链技术(RT-PCR)检测了上述组织中NY-ESO-1基因的表达水平,并利用DNA免疫杂交技术和测序技术检测RT-PCR产物.收集健康志愿者外周血基因组DNA作为正常对照.结果 在124例肝癌组织中,56例(45.2%)检测到有NY-ESO-1基因的表达,而在癌旁组织中未检测到表达.NY-ESO-1基因的RT-PCR产物长度为329 bp,利用测序方法检测NY-ESO-1基因突变.在56例表达NY-ESO-1的肝癌组织中,有4例检测到位点2的突变.该突变导致一个氨基酸的变异,这种氨基酸的变异对蛋白结构和功能具有决定性的影响.NY-ESO-1基因的表达与临床特征如肿瘤标志物(甲胎蛋白,半乳糖酸苷酶)、转移、复发和肿瘤的大小无显著关联性.结论 NY-ESO-1在肝癌组织中呈高表达,但是与预后无相关性.NY-ESO-1蛋白能否作为肝癌治疗的候选疫苗有待进一步研究.

  17. From Head-hunter to Organ-thief: Verisimilitude, Doubt and Plausible Worlds in Indonesia and Beyond

    DEFF Research Database (Denmark)

    Bubandt, Nils Ole

    2017-01-01

    In the last couple of years, so people in Indonesia claim, head-hunters – figures of dread and fascination that have haunted societies, politics, and the public imagination in Indonesia at least since colonial times – have begun to adopt a novel and troubling tactic. Instead of decapitating...... their victims and using the human heads in construction rituals as they used to do, head-hunters are now allegedly harvesting the victims’ organs for sale on the international organ market. Based on a comparison of ethnographic material from North Maluku, a province in the eastern part of Indonesia, and news...... reports I trace the shift from head-hunting to organ theft and suggest that this plasticity is not merely a symbolic representation of changing political and economic realities. Rather, I argue, the organ-stealing head-hunters are part of a global travelling package that includes and entangles organ...

  18. Diagnosis of Hunter's syndrome carriers; radioactive sulphate incorporation into fibroblasts in the presence of fructose 1-phosphate

    Energy Technology Data Exchange (ETDEWEB)

    Toennesen, T.; Lykkelund, C.; Guettler, F.

    1982-01-01

    Mutual correction of co-cultivated fibroblasts from patients with Hunter's and Hurler's syndrome could be inhibited by either fructose 1-phosphate or mannose 6-phosphate. In the presence of fructose 1-phosphate a 50% mixture of fibroblasts from a patient with Hunter's syndrome and a normal homozygous individual showed an increased /sup 35/S-sulphate incorporation into acid mucopolysaccharides. When fibroblast cultures from one obligate and two possible carriers of Hunter's syndrome were tested for /sup 35/S-sulphate incorporation, the cultures showed either twice the normal /sup 35/S-sulphate incorporation into acid mucopolysaccharides in the presence of fructose 1-phosphate or an abnormally high incorporation in the presence as well as in the absence of the sugar phosphate.

  19. MetaboHunter: an automatic approach for identification of metabolites from 1H-NMR spectra of complex mixtures

    Directory of Open Access Journals (Sweden)

    Culf Adrian

    2011-10-01

    Full Text Available Abstract Background One-dimensional 1H-NMR spectroscopy is widely used for high-throughput characterization of metabolites in complex biological mixtures. However, the accurate identification of individual compounds is still a challenging task, particularly in spectral regions with higher peak densities. The need for automatic tools to facilitate and further improve the accuracy of such tasks, while using increasingly larger reference spectral libraries becomes a priority of current metabolomics research. Results We introduce a web server application, called MetaboHunter, which can be used for automatic assignment of 1H-NMR spectra of metabolites. MetaboHunter provides methods for automatic metabolite identification based on spectra or peak lists with three different search methods and with possibility for peak drift in a user defined spectral range. The assignment is performed using as reference libraries manually curated data from two major publicly available databases of NMR metabolite standard measurements (HMDB and MMCD. Tests using a variety of synthetic and experimental spectra of single and multi metabolite mixtures show that MetaboHunter is able to identify, in average, more than 80% of detectable metabolites from spectra of synthetic mixtures and more than 50% from spectra corresponding to experimental mixtures. This work also suggests that better scoring functions improve by more than 30% the performance of MetaboHunter's metabolite identification methods. Conclusions MetaboHunter is a freely accessible, easy to use and user friendly 1H-NMR-based web server application that provides efficient data input and pre-processing, flexible parameter settings, fast and automatic metabolite fingerprinting and results visualization via intuitive plotting and compound peak hit maps. Compared to other published and freely accessible metabolomics tools, MetaboHunter implements three efficient methods to search for metabolites in manually curated

  20. Preliminary assessment of channel stability and bed-material transport along Hunter Creek, southwestern Oregon

    Science.gov (United States)

    Jones, Krista L.; Wallick, J. Rose; O'Connor, Jim E.; Keith, Mackenzie K.; Mangano, Joseph F.; Risley, John C.

    2011-01-01

    This preliminary assessment of (1) bed-material transport in the Hunter Creek basin, (2) historical changes in channel condition, and (3) supplementary data needed to inform permitting decisions regarding instream gravel extraction revealed the following: Along the lower 12.4 km (kilometers) of Hunter Creek from its confluence with the Little South Fork Hunter Creek to its mouth, the river has confined and unconfined segments and is predominately alluvial in its lowermost 11 km. This 12.4-km stretch of river can be divided into two geomorphically distinct study reaches based primarily on valley physiography. In the Upper Study Reach (river kilometer [RKM] 12.4-6), the active channel comprises a mixed bed of bedrock, boulders, and smaller grains. The stream is confined in the upper 1.4 km of the reach by a bedrock canyon and in the lower 2.4 km by its valley. In the Lower Study Reach (RKM 6-0), where the area of gravel bars historically was largest, the stream flows over bed material that is predominately alluvial sediments. The channel alternates between confined and unconfined segments. The primary human activities that likely have affected bed-material transport and the extent and area of gravel bars are (1) historical and ongoing aggregate extraction from gravel bars in the study area and (2) timber harvest and associated road construction throughout the basin. These anthropogenic activities likely have varying effects on sediment transport and deposition throughout the study area and over time. Although assessing the relative effects of these anthropogenic activities on sediment dynamics would be challenging, the Hunter Creek basin may serve as a case study for such an assessment because it is mostly free of other alterations to hydrologic and geomorphic processes such as flow regulation, dredging, and other navigation improvements that are common in many Oregon coastal basins. Several datasets are available that may support a more detailed physical assessment

  1. High frequency of lactose intolerance in a prehistoric hunter-gatherer population in northern Europe

    Directory of Open Access Journals (Sweden)

    Holmlund Gunilla

    2010-03-01

    Full Text Available Abstract Background Genes and culture are believed to interact, but it has been difficult to find direct evidence for the process. One candidate example that has been put forward is lactase persistence in adulthood, i.e. the ability to continue digesting the milk sugar lactose after childhood, facilitating the consumption of raw milk. This genetic trait is believed to have evolved within a short time period and to be related with the emergence of sedentary agriculture. Results Here we investigate the frequency of an allele (-13910*T associated with lactase persistence in a Neolithic Scandinavian population. From the 14 individuals originally examined, 10 yielded reliable results. We find that the T allele frequency was very low (5% in this Middle Neolithic hunter-gatherer population, and that the frequency is dramatically different from the extant Swedish population (74%. Conclusions We conclude that this difference in frequency could not have arisen by genetic drift and is either due to selection or, more likely, replacement of hunter-gatherer populations by sedentary agriculturalists.

  2. The coexistence of Baird's tapir (Tapirus bairdii) and indigenous hunters in northeastern Honduras.

    Science.gov (United States)

    Dunn, Marc; Estrada, Nereyda; Smith, Derek A

    2012-12-01

    The Baird's tapir (Tapirus bairdii) is a popular game species throughout Central America, particularly among indigenous populations, and is currently endangered. Research on Miskitu hunting was conducted over 4 months in a remote region in northeastern Honduras that overlaps with the Río Plátano Biosphere Reserve. The hunting zone was mapped together with hunters and interviews were conducted with elders and other community members about tapir hunting. Results show that tapir harvesting is targeted toward specific habitats at specific times of year. Harvest rates for one year suggest that tapir hunting in the area exceeds estimates of maximum sustainable production. Nevertheless, field surveys reveal the presence of tapir within 1 km of the community, and its harvest tends to be nearby, in both forested and agricultural landscapes, suggesting that the animal has not been depleted in the area. It appears that the existence of forest areas adjacent to the hunting zone that do not experience hunting, together with the anthropogenic habitats created through shifting cultivation, are factors that help explain the presence of tapirs in the area. The article concludes with a discussion regarding the potential positive role of indigenous hunters in tapir conservation throughout its distribution range.

  3. Síndrome de Hunter Mucopolisacaridosis (II:reporte de un caso

    Directory of Open Access Journals (Sweden)

    Ghunter Paz

    2011-06-01

    Full Text Available El síndrome de Hunter, es una alteración genética que afecta principalmente a los varones, debido a la deficiencia o ausencia de la enzima iduronato-2-sulfatasa, que interfiere con lacapacidad del cuerpo de descomponer y reciclar los mucopolisacáridos. La incidencia es de 1:10.000 a 1:25.000 de recién nacidos vivos. Las manifestaciones físicas, incluyen rasgos faciales distintivos, cabeza grande, abdomen aumentado, engrosamiento de válvulas cardíacas, enfermedad respiratoria obstructiva, retraso del desarrollo mental y aumento de tamaño del hígado y del bazo.Presentamos el caso clínico de un paciente de sexo masculino de 7 años de edad, con diagnostico de síndrome de Hunter hace seis años, con antecedentes de crisis convulsivas en dos oportunidades y cuadros de bronconeumonía.Al examen físico presenta fascie tosca, contractura en musculo bíceps braquial, se logra la extensión de las manos, camina con la punta de los pies y presenta hepato y esplenomegalia. Al cual se le trató la sintomatología respiratoria con el uso de antibióticos.

  4. Current views on hunter-gatherer nutrition and the evolution of the human diet.

    Science.gov (United States)

    Crittenden, Alyssa N; Schnorr, Stephanie L

    2017-01-01

    Diet composition and food choice are not only central to the daily lives of all living people, but are consistently linked with turning points in human evolutionary history. As such, scholars from a wide range of fields have taken great interest in the role that subsistence has played in both human cultural and biological evolution. Central to this discussion is the diet composition and nutrition of contemporary hunters and gatherers, who are frequently conscripted as model populations for ancestral human nutrition. Research among the world's few remaining foraging populations is experiencing a resurgence, as they are making the final transition away from diets composed of wild foods, to those dominated by domesticated cultigens and/or processed foods. In an effort to glean as much information as possible, before such populations are no longer hunting and gathering, researchers interested in the evolution of human nutrition are rapidly collecting and accessing new and more data. Methods of scientific inquiry are in the midst of rapid change and scholars are able to revisit long-standing questions using state of the art analyses. Here, using the most relevant findings from studies in ethnography, nutrition, human physiology, and microbiomes, we provide a brief summary of the study of the evolution of human nutrition as it has specifically pertained to data coming from living hunter-gatherers. In doing so, we hope to bridge the disciplines that are currently invested in research on nutrition and health among foraging populations. © 2017 American Association of Physical Anthropologists.

  5. Dietary resilience among hunter-gatherers of Tierra del Fuego: Isotopic evidence in a diachronic perspective.

    Science.gov (United States)

    Tafuri, Mary Anne; Zangrando, Atilio Francisco Javier; Tessone, Augusto; Kochi, Sayuri; Moggi Cecchi, Jacopo; Di Vincenzo, Fabio; Profico, Antonio; Manzi, Giorgio

    2017-01-01

    The native groups of Patagonia have relied on a hunter-gatherer economy well after the first Europeans and North Americans reached this part of the world. The large exploitation of marine mammals (i.e., seals) by such allochthonous groups has had a strong impact on the local ecology in a way that might have forced the natives to adjust their subsistence strategies. Similarly, the introduction of new foods might have changed local diet. These are the premises of our isotopic-based analysis. There is a large set of paleonutritional investigations through isotopic analysis on Fuegians groups, however a systematic exploration of food practices across time in relation to possible pre- and post-contact changes is still lacking. In this paper we investigate dietary variation in hunter-gatherer groups of Tierra del Fuego in a diachronic perspective, through measuring the isotopic ratio of carbon (∂13C) and nitrogen (∂15N) in the bone collagen of human and a selection of terrestrial and marine animal samples. The data obtained reveal an unexpected isotopic uniformity across prehistoric and recent groups, with little variation in both carbon and nitrogen mean values, which we interpret as the possible evidence of resilience among these groups and persistence of subsistence strategies, allowing inferences on the dramatic contraction (and extinction) of Fuegian populations.

  6. Early and Middle Holocene Hunter-Gatherer Occupations in Western Amazonia: The Hidden Shell Middens

    Science.gov (United States)

    Lombardo, Umberto; Szabo, Katherine; Capriles, José M.; May, Jan-Hendrik; Amelung, Wulf; Hutterer, Rainer; Lehndorff, Eva; Plotzki, Anna; Veit, Heinz

    2013-01-01

    We report on previously unknown early archaeological sites in the Bolivian lowlands, demonstrating for the first time early and middle Holocene human presence in western Amazonia. Multidisciplinary research in forest islands situated in seasonally-inundated savannahs has revealed stratified shell middens produced by human foragers as early as 10,000 years ago, making them the oldest archaeological sites in the region. The absence of stone resources and partial burial by recent alluvial sediments has meant that these kinds of deposits have, until now, remained unidentified. We conducted core sampling, archaeological excavations and an interdisciplinary study of the stratigraphy and recovered materials from three shell midden mounds. Based on multiple lines of evidence, including radiocarbon dating, sedimentary proxies (elements, steroids and black carbon), micromorphology and faunal analysis, we demonstrate the anthropogenic origin and antiquity of these sites. In a tropical and geomorphologically active landscape often considered challenging both for early human occupation and for the preservation of hunter-gatherer sites, the newly discovered shell middens provide evidence for early to middle Holocene occupation and illustrate the potential for identifying and interpreting early open-air archaeological sites in western Amazonia. The existence of early hunter-gatherer sites in the Bolivian lowlands sheds new light on the region’s past and offers a new context within which the late Holocene “Earthmovers” of the Llanos de Moxos could have emerged. PMID:24013964

  7. Early and middle holocene hunter-gatherer occupations in western Amazonia: the hidden shell middens.

    Science.gov (United States)

    Lombardo, Umberto; Szabo, Katherine; Capriles, José M; May, Jan-Hendrik; Amelung, Wulf; Hutterer, Rainer; Lehndorff, Eva; Plotzki, Anna; Veit, Heinz

    2013-01-01

    We report on previously unknown early archaeological sites in the Bolivian lowlands, demonstrating for the first time early and middle Holocene human presence in western Amazonia. Multidisciplinary research in forest islands situated in seasonally-inundated savannahs has revealed stratified shell middens produced by human foragers as early as 10,000 years ago, making them the oldest archaeological sites in the region. The absence of stone resources and partial burial by recent alluvial sediments has meant that these kinds of deposits have, until now, remained unidentified. We conducted core sampling, archaeological excavations and an interdisciplinary study of the stratigraphy and recovered materials from three shell midden mounds. Based on multiple lines of evidence, including radiocarbon dating, sedimentary proxies (elements, steroids and black carbon), micromorphology and faunal analysis, we demonstrate the anthropogenic origin and antiquity of these sites. In a tropical and geomorphologically active landscape often considered challenging both for early human occupation and for the preservation of hunter-gatherer sites, the newly discovered shell middens provide evidence for early to middle Holocene occupation and illustrate the potential for identifying and interpreting early open-air archaeological sites in western Amazonia. The existence of early hunter-gatherer sites in the Bolivian lowlands sheds new light on the region's past and offers a new context within which the late Holocene "Earthmovers" of the Llanos de Moxos could have emerged.

  8. NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery.

    Science.gov (United States)

    Xu, Heng; Gu, Na; Liu, Zhao-Bo; Zheng, Min; Xiong, Fang; Wang, Si-Ying; Li, Ning; Lu, Jun

    2012-01-01

    NY-ESO-1 belongs to the cancer testis antigens (CTA) family, and is identified in a variety of tumors. Certain studies have demonstrated that NY-ESO-1 predicts tumor recurrence and treatment response. No reports are currently available regarding the correlation between NY-ESO-1 and the recurrence of hepatocellular carcinoma (HCC) following surgery. The purpose of the present study was to evaluate the association between NY-ESO-1 and relapse of HCC and to explore the possible mechanisms for this correlation. A total of 120 HCC patients were analyzed for the expression of NY-ESO-1 by immunohistochemistry (IHC). A stable NY-ESO-1 over-expressed HepG2 cell line (ESO-HepG2) was established to determine the biological effects of NY-ESO-1 on cell proliferation, cell cycle and migration by using the xCELLigence DP system, flow cytometry and xCELLigence SP system. NY-ESO-1 was positive in 28 of 120 (23.3%) HCC tumor tissues. NY-ESO-1 was not detectable in adjacent normal liver tissues. A close correlation was found between NY-ESO-1 expression and the recurrence of HCC following surgery (P=0.007). Kaplan-Meier analysis showed a shorter recurrence-free survival (RFS) for patients positive for NY-ESO-1 (log-rank test, P=0.003). The Cox regression model demonstrated that NY-ESO-1 expression was a significant independent predictor for the recurrence of HCC following curative surgery (P=0.022). Compared with HepG2 cells, ESO-HepG2 cells have increased migration but not proliferation ability. In conclusion, NY-ESO-1 expression is associated with worse HCC outcome following surgery, and the mechanism for this finding may be that NY-ESO-1 increases tumor cell migration.

  9. THERMOMECHANICAL ANALYSIS OF ILLITE FROM FÜZÉRRADVÁNY

    Directory of Open Access Journals (Sweden)

    Tomáš Húlan

    2015-09-01

    Full Text Available Young’s modulus of green illite from Füzérradvány (Hungary was measured in-situ in the temperature interval 20 °C – 1100 °C and auxiliary analyses DTA, TG and TDA, XRD and EGA, were also performed. It was found that a removal of the physically bound water (20 °C – 250 °C sets illite crystals closer which leads to a significant increase of Young’s modulus from its initial value of 7 GPa and reaches the maximum 12 GPa at 300 °C. Young’s modulus slightly decreases in the temperature interval of dehydroxylation of illite (300 °C – 800 °C, and which then reaches up to 45 GPa at 1100 °C, increasing exponentially as a consequence of the sintering above 800 °C.DOI: http://dx.doi.org/10.5755/j01.ms.21.3.7152

  10. 肿瘤抗原NY-ESO-1研究进展

    Institute of Scientific and Technical Information of China (English)

    王运伟; 顾琴龙; 朱正纲

    2005-01-01

    肿瘤抗原NY-ESO-1是肿瘤-睾丸(cancer-testis,CT)抗原,其编码基因是一基因家族,目前发现的主要包括NY-ESO-1、LAGE-1和ESO3三个成员.NY-ESO-1是迄今发现的最具免疫原性的肿瘤抗原之一,可以在NY-ESO-1表达阳性的肿瘤患者体内引起自发性体液免疫反应和T细胞免疫反应,因此在抗原特异性肿瘤免疫治疗中具有广泛的应用前景.

  11. EnviroAtlas - New York, NY - One Meter Resolution Urban Land Cover Data (2008) Web Service

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas ). The New York, NY EnviroAtlas...

  12. EnviroAtlas - New York, NY - Meter-Scale Urban Land Cover (MULC) Data (2008)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The New York, NY EnviroAtlas Meter-scale Urban Land Cover (MULC) Data were generated by the University of Vermont Spatial Analysis Laboratory (SAL) under the...

  13. LiDAR Elevation Data Collection - Putnam County, NY, 2008 (NYSDEC)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Summary of the surface elevation data collection project in Putnam County, NY (NYSDEC) 2008. Products generated include LiDAR point data in LAS Binary format v1.1....

  14. 76 FR 4078 - Television Broadcasting Services; North Pole and Plattsburgh, NY

    Science.gov (United States)

    2011-01-24

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 Television Broadcasting Services; North Pole and Plattsburgh, NY AGENCY: Federal... CFR Part 73 Television, Television broadcasting. For the reasons discussed in the preamble,...

  15. EnviroAtlas - New York, NY - One Meter Resolution Urban Land Cover Data (2008)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The New York, NY EnviroAtlas Meter-scale Urban Land Cover (MULC) Data were generated by the University of Vermont Spatial Analysis Laboratory (SAL) under the...

  16. Advances in the Research of Tumor Antigen NY-ESO-1%肿瘤抗原NY-ESO-1研究进展

    Institute of Scientific and Technical Information of China (English)

    高丹

    2008-01-01

    NY-ESO-1是肿瘤-睾丸(cancer-testis,CT)抗原家族成员之一,在许多不同类型的人类肿瘤中都有表达,是迄今发现的最具免疫原性的肿瘤抗原之一.NY-ESO-1可以在阳性表达肿瘤患者体内诱导自发性体液和T细胞免疫应答,因此在肿瘤疫苗研制中具有非常广泛的前景.

  17. T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma

    OpenAIRE

    Singh, Nathan; Kulikovskaya, Irina; Barrett, David M.; Binder-Scholl, Gwendolyn; Jakobsen, Bent; Martinez, Daniel; Pawel, Bruce; June, Carl H.; Kalos, Michael D.; Grupp, Stephan A.

    2015-01-01

    The cancer-testis antigen NY-ESO-1 is expressed by many solid tumors and has limited expression by mature somatic tissues, making it a highly attractive target for tumor immunotherapy. Targeting NY-ESO-1 using engineered T cells has demonstrated clinical efficacy in the treatment of some adult tumors. Neuroblastoma is a significant cause of cancer mortality in children, and is a tumor type shown to be responsive to immunotherapies. We evaluated a large panel of primarily resected neuroblastom...

  18. NY-ESO-1 expression is tightly linked to TMPRSS2-ERG fusion in prostate cancer.

    Science.gov (United States)

    Grupp, Katharina; Ospina-Klinck, Daniel; Tsourlakis, Maria Christina; Koop, Christina; Wilczak, Waldemar; Adam, Meike; Simon, Ronald; Sauter, Guido; Izbicki, Jakob Robert; Graefen, Markus; Huland, Hartwig; Steurer, Stefan; Schlomm, Thorsten; Minner, Sarah; Quaas, Alexander

    2014-07-01

    NY-ESO-1 has been suggested as therapeutic cancer vaccine in prostate cancer. This study was undertaken to explore the relationship of NY-ESO-1 with tumor phenotype, biochemical recurrence, and molecular subgroups in hormone-naive prostate cancers. NY-ESO-1 immunohistochemistry was analyzed on a tissue microarray containing 11,152 prostate cancer samples. Results were compared to clinically follow-up data, ERG status, and deletions on PTEN, 3p13, 5q21, and 6q15. NY-ESO-1 expression was absent in benign prostate glands. In prostate cancer, NY-ESO-1 positivity was found 8.8% of our 8,761 interpretable tumors including 5.8% with weak, 2.5% with moderate, and 0.5% with strong expression. There was a threefold higher rate of NY-ESO-1 expression in ERG fusion positive tumors than in ERG negative cancers (P ESO-1 expression was associated with early biochemical recurrence (P = 0.0002) and high Gleason grade (P ESO-1 expression was also linked to PTEN (P = 0.0012) and 6q15 deletions (P = 0.0005). Our observations indicate a tight link of NY-ESO-1 expression to ERG activation and (to a lesser extent) PTEN- and 6q15-deletions in prostate cancer. The impact of these interactions on the likelihood of response to immunotherapy is unclear. The prognostic impact of NY-ESO-1 expression is little and not independent of histologic variables. © 2014 Wiley Periodicals, Inc.

  19. Diagnostic and therapeutic relevance of NY-ESO-1 expression in oral squamous cell carcinoma.

    Science.gov (United States)

    Ries, Jutta; Mollaoglu, Nur; Vairaktaris, Eleftherios; Neukam, Friedrich W; Nkenke, Emeka

    2009-12-01

    Cancer/testis antigen 1B (NY-ESO-1) is exclusively expressed in various types of tumor but not in healthy normal tissue, except testis, and induces strong cellular and humoral immune responses. Therefore, it represents an ideal target for diagnostic and immunotherapeutic applications. The aim of the study was to investigate the expression of NY-ESO-1 in oral squamous cell carcinoma (OSCC) to determine its impact as a diagnostic parameter or a therapeutic target for oral cancer. A total of 65 OSCC and 20 normal oral mucosal samples of otherwise healthy volunteers were included in this study. Expression of NY-ESO-1 was determined using reverse transcriptase polymerase chain reaction (RT-PCR). The results were correlated to diagnosis and clinicopathological parameters. NY-ESO-1 was expressed in 27.7% of the investigated tumor samples, but not in normal oral mucosal. The correlation between NY-ESO-1 expression and malignancy was significant (p=0.008). The prevalence of NY-ESO-1 expression was significantly associated with tumor size (p=0.033), but not with histological grading, positive lymph node status or clinical stage of disease. NY-ESO-1 expression is restricted to OSCC, clearly indicating malignancy. However, the expression rate of this antigen is too low for clinical application but it might be a useful additional biomarker within a multiple marker system for the diagnosis of OSCC. In addition, NY-ESO-1 might be a candidate for immunotherapy and polyvaccination in patients suffering from OSCC.

  20. Three novel NY-ESO-1 epitopes bound to DRB1*0803, DQB1*0401 and DRB1*0901 recognized by CD4 T cells from CHP-NY-ESO-1-vaccinated patients.

    Science.gov (United States)

    Mizote, Yu; Taniguchi, Taku; Tanaka, Kei; Isobe, Midori; Wada, Hisashi; Saika, Takashi; Kita, Shoichi; Koide, Yukari; Uenaka, Akiko; Nakayama, Eiichi

    2010-07-19

    Three novel NY-ESO-1 CD4 T cell epitopes were identified using PBMC obtained from patients who were vaccinated with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein (CHP-NY-ESO-1). The restriction molecules were determined by antibody blocking and using various EBV-B cells with different HLA alleles as APC to present peptides to CD4 T cells. The minimal epitope peptides were determined using various N- and C-termini truncated peptides deduced from 18-mer overlapping peptides originally identified for recognition. Those epitopes were DRB1*0901-restricted NY-ESO-1 87-100, DQB1*0401-restricted NY-ESO-1 95-107 and DRB1*0803-restricted NY-ESO-1 124-134. CD4 T cells used to determine those epitope peptides recognized EBV-B cells or DC that were treated with recombinant NY-ESO-1 protein or NY-ESO-1-expressing tumor cell lysate, suggesting that the epitope peptides are naturally processed. These CD4 T cells showed a cytokine profile with Th1 characteristics. Furthermore, NY-ESO-1 87-100 peptide/HLA-DRB1*0901 tetramer staining was observed. Multiple Th1-type CD4 T cell responses are beneficial for inducing effective anti-tumor responses after NY-ESO-1 protein vaccination. (c) 2010 Elsevier Ltd. All rights reserved.

  1. NY-ESO-1 (CTAG1B) expression in mesenchymal tumors.

    Science.gov (United States)

    Endo, Makoto; de Graaff, Marieke A; Ingram, Davis R; Lim, Simin; Lev, Dina C; Briaire-de Bruijn, Inge H; Somaiah, Neeta; Bovée, Judith V M G; Lazar, Alexander J; Nielsen, Torsten O

    2015-04-01

    New York esophageal squamous cell carcinoma 1 (NY-ESO-1, CTAG1B) is a cancer-testis antigen and currently a focus of several targeted immunotherapeutic strategies. We performed a large-scale immunohistochemical expression study of NY-ESO-1 using tissue microarrays of mesenchymal tumors from three institutions in an international collaboration. A total of 1132 intermediate and malignant and 175 benign mesenchymal lesions were enrolled in this study. Immunohistochemical staining was performed on tissue microarrays using a monoclonal antibody for NY-ESO-1. Among mesenchymal tumors, myxoid liposarcomas showed the highest positivity for NY-ESO-1 (88%), followed by synovial sarcomas (49%), myxofibrosarcomas (35%), and conventional chondrosarcomas (28%). Positivity of NY-ESO-1 in the remaining mesenchymal tumors was consistently low, and no immunoreactivity was observed in benign mesenchymal lesions. On the basis of these findings, nearly 90% of myxoid liposarcomas, as well as a significant proportion of synovial sarcomas, myxofibrosarcomas, and conventional chondrosarcomas are good candidates for immunotherapy targeting NY-ESO-1.

  2. NY-ESO-1 as a potential immunotherapeutic target in renal cell carcinoma.

    Science.gov (United States)

    Giesen, Eva; Jilaveanu, Lucia B; Parisi, Fabio; Kluger, Yuval; Camp, Robert L; Kluger, Harriet M

    2014-07-30

    Novel immune therapies targeting tumor specific antigens are being developed. Our purpose was to determine expression of the cancer testes antigen NY-ESO-1 in renal cell carcinoma (RCC), as NY-ESO-1 targeting approaches, particularly adoptive cell therapy, have not been evaluated in this disease. We employed tissue microarrays containing >300 unique RCC cases and adjacent benign renal tissue to determine NY-ESO-1 expression using a quantitative immunofluorescence method. In addition, we studied NY-ESO-1 expression in 35 matched primary and metastatic RCC specimens to assess concordance between different tumor sites. NY-ESO-1 was highly expressed in a subset of RCCs. Expression in primary RCC specimens was significantly higher than adjacent normal renal tissue (PESO-1 expression seen in clear cell RCC suggests that NY-ESO-1 targeting approaches should be studied in this disease. Expression is higher in metastatic sites, and discordance between primary and metastatic sites in some patients suggests that patient selection for these therapies should be based on expression in metastatic rather than nephrectomy specimens.

  3. Supplemental Colleges

    Data.gov (United States)

    Department of Homeland Security — The Supplemental Colleges layer attempts to capture additional Post Secondary Education campuses of colleges and universities associated with a single campus listed...

  4. Clay Modeling as a Method to Learn Human Muscles: A Community College Study

    Science.gov (United States)

    Motoike, Howard K.; O'Kane, Robyn L.; Lenchner, Erez; Haspel, Carol

    2009-01-01

    The efficacy of clay modeling compared with cat dissection for human muscle identification was examined over two semesters at LaGuardia Community College in Queens, NY. The 181 students in 10 sections in this study were randomly distributed into control (cat dissection) and experimental (clay modeling) groups, and the results of the muscle…

  5. Atmospheric Research in Ny-Aalesund. Proceedings from the Third NySMAC meeting. NILU, Kjeller, Norway, 9.-11. April 1997

    Energy Technology Data Exchange (ETDEWEB)

    Floeisand, Inga; Gernandt, Hartwig; Larsen, Elisabeth Stoltz; Stordal, Frode; Wada, Makoto

    1997-07-01

    Leading abstract. The Ny-Aalesund Seminar Series was conceived by NySMAC (Ny-Aalesund Science Managers Committee) as a means of bringing together research scientists involved in programmes running at Ny-Aalesund or having an interest in that area. The first Seminar was held in Potsdam in Germany in May 1995, and included talks which covered all current research disciplines; physical, atmospheric, earth and biological sciences. The Second Seminar was devoted to biological science and particularly to ecology. It was held in Cambridge in UK in February 1996. The subject of this Third Seminar, held in Kjeller in Norway in April 1997, is atmospheric research in Ny-Aalesund. Since the early 1980s a wide range of projects have been carried out on Svalbard and particularly at Ny-Aalesund. Prominent in this research have been several international research programmes with emphasis on topics of e.g. Arctic (Arctic Monitoring and Assessment Programme, AMAP), European (European Monitoring and Evaluation Programme, EMEP) or global (International Geosphere-Biosphere Programme, IGBP; World Climate Research Programme, WCRP) scales. Atmospheric observations have been carried out in Ny-Aalesund in Svalbard for several years. From the early 1980s, the long range transport of sulphur dioxide and sulphate aerosols leading to Arctic Haze, has been studied. As a consequence, EMEP included Ny-Aalesund in their network. In the following years the transport of ozone and chemical precursors were observed, and recently the naturally occurring phenomenon of rapid surface ozone loss has been given particular attention. From the late 1980s observations of the stratospheric ozone layer and related chemical species were undertaken, and the efforts have increased considerably since. Ny-Aalesund is now one of the primary Arctic sites of the NDSC (Network for Detection of Stratospheric Change) network. Important efforts have been undertaken to participate in the European campaigns as the European

  6. [Prokaryotic expression, purification and identification of NY-ESO-1/GST fusion protein in E.coli].

    Science.gov (United States)

    Tang, Lei; Song, Chao-jun; Sun, Yuan-jie; Li, Na; Wei, Yu-ying; Sun, Yi; Yang, Kun

    2012-10-01

    To construct an expression plasmid for NY-ESO-1 gene and identify the expression of recombinant protein NY-ESO-1/GST in E.coli. NY-ESO-1 segment was amplified from the testis cDNA library by RT-PCR and cloned into the prokaryotic expression vector pGEX4T-1 downstream tagged by GST to construct the expression plasmid pGEX-4T1-NY-ESO-1. The recombinant vector was transformed to BL21 (DE3) and NY-ESO-1/GST fusion protein was induced expression by IPTG. The protein was purified by urea elution and identified by SDS-PAGE and Western blotting. The NY-ESO-1 segment was successfully amplified and its sequence was identical with that published in GenBank. The BL21 (DE3) pLysS containing the pGEX-4T1-NY-ESO-1 expressed a M(r); 44 000 fusion protein under the induction of IPTG. The purity of the protein was 90%. Western blotting proved that NY-ESO-1/GST had a specific reaction with anti-GST mAb. The prokaryotic expression vector of NY-ESO-1 has been constructed and the fusion protein NY-ESO-1/GST of high purity is successfully expressed.

  7. Under What Conditions Do Children Thrive in the Madeline Hunter Model? A Report of Project Follow Through, Napa, California.

    Science.gov (United States)

    Stallings, Jane; And Others

    This study evaluated the effect of a comprehensive training program for teachers based on Madeline Hunter's Instructional Theory Into Practice (ITIP). To examine the question of implementation, teachers in the first through fourth grades in Napa Valley elementary schools were observed teaching two reading and two mathematics classes before and…

  8. Arrowheads as indicators of interpersonal violence and group identity among the Neolithic Pitted Ware hunters of southwestern Scandinavia

    DEFF Research Database (Denmark)

    Iversen, Rune

    2016-01-01

    The three main types of tanged flint arrowheads (A, B, and C) characteristic of the Neolithic Pitted Ware hunter, fisher and gatherers of southwestern Scandinavia are traditionally viewed as chronological conditioned. However, recent studies have shown their simultaneity during the early 3rd mill...

  9. Quest for water in coastal Georgia: assessment of alternative water sources at Hunter Army Airfield, Chatham County, Georgia

    Science.gov (United States)

    Clarke, John S.

    2011-01-01

    To meet growing demands for water in the coastal Georgia area, the U.S. Geological Survey, in cooperation with the U.S. Department of the Army, conducted detailed site investigations and modeling studies at Hunter Army Airfield to assess the water-bearing potential of ponds and wells completed in the Lower Floridan aquifer.

  10. Effect of hunter selectivity on harvest rates of radio-collared white-tailed deer in Pennsylvania

    Science.gov (United States)

    Buderman, Frances E.; Diefenbach, Duane R.; Rosenberry, C.S.; Wallingford, Bret D.; Long, Eric S.

    2014-01-01

    Radio transmitters are a commonly used tool for monitoring the fates of harvested species, although little research has been devoted to whether a visible radio transmitter changes a hunters' willingness to harvest that animal. We initially surveyed deer hunters to assess their willingness to harvest radio-collared deer and predicted radio collars were unlikely to affect the harvest of antlerless deer, but hunters may be less willing to harvest small-antlered males with radio collars compared to large-antlered males. We fitted white-tailed deer (Odocoileus virginianus) with radio collars that were visible to hunters or with ear-tag transmitters or ear-tags that were difficult to detect visually and estimated if harvest rates differed among marking methods. For females, the best model failed to detect an effect of radio collars on harvest rates. Also, we failed to detect a difference between male deer fitted with radio collars and ear-tag transmitters. When we compared males fitted with radio collars versus ear tags, we found harvest rate patterns were opposite to our predictions, with lower harvest rates for adult males fitted with radio collars and higher harvest rates for yearling males fitted with radio collars. Our study suggests that harvest rate estimates generated from a sample of deer fitted with visible radio collars can be representative of the population of inference. 

  11. From Head-hunter to Organ-thief: Verisimilitude, Doubt and Plausible Worlds in Indonesia and Beyond

    DEFF Research Database (Denmark)

    Bubandt, Nils Ole

    2017-01-01

    In the last couple of years, so people in Indonesia claim, head-hunters – figures of dread and fascination that have haunted societies, politics, and the public imagination in Indonesia at least since colonial times – have begun to adopt a novel and troubling tactic. Instead of decapitating...

  12. Core Hunter II: fast core subset selection based on multiple genetic diversity measures using Mixed Replica search

    Directory of Open Access Journals (Sweden)

    Beukelaer Herman De

    2012-11-01

    Full Text Available Abstract Background Sampling core subsets from genetic resources while maintaining as much as possible the genetic diversity of the original collection is an important but computationally complex task for gene bank managers. The Core Hunter computer program was developed as a tool to generate such subsets based on multiple genetic measures, including both distance measures and allelic diversity indices. At first we investigate the effect of minimum (instead of the default mean distance measures on the performance of Core Hunter. Secondly, we try to gain more insight into the performance of the original Core Hunter search algorithm through comparison with several other heuristics working with several realistic datasets of varying size and allelic composition. Finally, we propose a new algorithm (Mixed Replica search for Core Hunter II with the aim of improving the diversity of the constructed core sets and their corresponding generation times. Results Our results show that the introduction of minimum distance measures leads to core sets in which all accessions are sufficiently distant from each other, which was not always obtained when optimizing mean distance alone. Comparison of the original Core Hunter algorithm, Replica Exchange Monte Carlo (REMC, with simpler heuristics shows that the simpler algorithms often give very good results but with lower runtimes than REMC. However, the performance of the simpler algorithms is slightly worse than REMC under lower sampling intensities and some heuristics clearly struggle with minimum distance measures. In comparison the new advanced Mixed Replica search algorithm (MixRep, which uses heterogeneous replicas, was able to sample core sets with equal or higher diversity scores than REMC and the simpler heuristics, often using less computation time than REMC. Conclusion The REMC search algorithm used in the original Core Hunter computer program performs well, sometimes leading to slightly better results

  13. Una valigia caduta in mare: Jaume Serra Hunter e la "Scuola di Barcellona"

    Directory of Open Access Journals (Sweden)

    Nazzareno Fioraso

    2014-12-01

    Full Text Available Nella storiografia filosofica spagnola non esiste, probabilmente, una definizione ambigua e problematica come quella che riguarda la cosiddetta "Scuola di Barcellona". La tesi principale di questo articolo è che tale scuola non giunse mai a nascere, ma ne esistette soltanto una forma embrionale che non poté maturare perché, in conseguenza della situazione politica venutasi a creare con la guerra civile (1936-1939, i suoi componenti si dispersero nell'esilio. Ciò nonostante, è possibile riconoscere alcuni tratti comuni, seppur labili e (forse non sostanziali, nella diaspora degli intellettuali catalani che rendono possibile definirla, con le dovute cautele, "Scuola di Barcellona". Tali caratteristiche comuni si possono far risalire a colui che, in un certo senso, fu il fondatore della scuola, essendo il principale maestro delle nuove leve filosofiche della Catalogna all'inizio del XX secolo: Jaume Serra Hunter.

  14. The curvature of semidirect product groups associated with two-component Hunter-Saxton systems

    Science.gov (United States)

    Kohlmann, Martin

    2011-06-01

    In this paper, we study two-component versions of the periodic Hunter-Saxton equation and its μ-variant. Considering both equations as a geodesic flow on the semidirect product of the circle diffeomorphism group Diff( S) with a space of scalar functions on S we show that both equations are locally well posed. The main result of this paper is that the sectional curvature associated with the 2HS is constant and positive and that 2µHS allows for a large subspace of positive sectional curvature. The issues of this paper are related to some of the results for 2CH and 2DP presented in Escher et al (2011 J. Geom. Phys. 61 436-52).

  15. Evolutionary or fragmented environmental policy making? coal, power, and agriculture in the Hunter Valley, Australia

    Science.gov (United States)

    Day, Diana G.

    1988-05-01

    Intensified surface mining, power generation, and smelting operations in the Hunter River lowlands, NSW, Australia have posed numerous new environmental management problems. Legislative controls over water, soils, and land use management have been clearly insufficient and remain so. The complex range of environmental changes is challenging government agencies as well as coal developers. While water demands are increasing in the region the proportionally greatest competitors are power generation and irrigation. Comprehensive regional water quality assessment is inadequate and divided between a number of agencies with fragmentary interests. Coal development inquiries signal further controversy over appropriate management solutions and are an ongoing phenomenon in the region. The early 1980s resource boom has been followed by lower rates of economic growth, which have resulted in disparate agency responses to major ongoing environmental questions. While issue attention cycles are often remarkably short in environmental management, matters of water, land, and air quality require intensive and ongoing monitoring and policy development.

  16. Symmetry Analysis and Conservation Laws for the Hunter-Saxton Equation

    Institute of Scientific and Technical Information of China (English)

    Mehdi Nadjafikhah; Fatemeh Ahangari

    2013-01-01

    In this paper,the problem of determining the most generalLie point symmetries group and conservation laws of a well known nonlinear hyperbolic PDE in mathematical physics called the Hunter-Saxton equation (HSE) is analyzed.By applying the basic Lie symmetry method for the HSE,the classical Lie point symmetry operators are obtained.Also,the algebraic structure of the Lie algebra of symmetries is discussed and an optimal system of one-dimensional subalgebras of the HSE symmetry algebra which creates the preliminary classification of group invariant solutions is constructed.Particularly,the Lie invariants as well as similarity reduced equations corresponding to infinitesimal symmetries are obtained.Mainly,the conservation laws of the HSE are computed via three different methods including Boyer's generalization of Noether's theorem,first homotopy method and second homotopy method.

  17. Maximum likelihood methods for investigating reporting rates of rings on hunter-shot birds

    Science.gov (United States)

    Conroy, M.J.; Morgan, B.J.T.; North, P.M.

    1985-01-01

    It is well known that hunters do not report 100% of the rings that they find on shot birds. Reward studies can be used to estimate what this reporting rate is, by comparison of recoveries of rings offering a monetary reward, to ordinary rings. A reward study of American Black Ducks (Anas rubripes) is used to illustrate the design, and to motivate the development of statistical models for estimation and for testing hypotheses of temporal and geographic variation in reporting rates. The method involves indexing the data (recoveries) and parameters (reporting, harvest, and solicitation rates) by geographic and temporal strata. Estimates are obtained under unconstrained (e.g., allowing temporal variability in reporting rates) and constrained (e.g., constant reporting rates) models, and hypotheses are tested by likelihood ratio. A FORTRAN program, available from the author, is used to perform the computations.

  18. Planet Hunters: New Kepler planet candidates from analysis of quarter 2

    CERN Document Server

    Lintott, Chris; Sharzer, Charlie; Fisher, Debra A; Barclay, Thomas; Parrish, Michael; Batalha, Natalie; Bryson, Steve; Jenkins, Jon; Ragozzine, Darin; Rowe, Jason F; Schawinski, Kevin; Gagliano, Rovert; Gilardi, Joe; Jek, Kian J; Pääkkönen, Jari-Pekka; Smits, Tjapko

    2012-01-01

    We present new planet candidates identified in NASA Kepler quarter two public release data by volunteers engaged in the Planet Hunters citizen science project. The two candidates presented here survive checks for false-positives, including examination of the pixel offset to constrain the possibility of a background eclipsing binary. The orbital periods of the planet candidates are 97.46 days (KIC 4552729) and 284.03 (KIC 10005758) days and the modeled planet radii are 5.3 and 3.790 R_Earth. The latter star has an additional known planet candidate with a radius of 5.05 R_Earth and a period of 134.49 which was detected by the Kepler pipeline. The discovery of these candidates illustrates the value of massively distributed volunteer review of the Kepler database to recover candidates which were otherwise uncatalogued.

  19. Emergence of social complexity among coastal hunter-gatherers in the Atacama Desert of northern Chile.

    Science.gov (United States)

    Marquet, Pablo A; Santoro, Calogero M; Latorre, Claudio; Standen, Vivien G; Abades, Sebastián R; Rivadeneira, Marcelo M; Arriaza, Bernardo; Hochberg, Michael E

    2012-09-11

    The emergence of complex cultural practices in simple hunter-gatherer groups poses interesting questions on what drives social complexity and what causes the emergence and disappearance of cultural innovations. Here we analyze the conditions that underlie the emergence of artificial mummification in the Chinchorro culture in the coastal Atacama Desert in northern Chile and southern Peru. We provide empirical and theoretical evidence that artificial mummification appeared during a period of increased coastal freshwater availability and marine productivity, which caused an increase in human population size and accelerated the emergence of cultural innovations, as predicted by recent models of cultural and technological evolution. Under a scenario of increasing population size and extreme aridity (with little or no decomposition of corpses) a simple demographic model shows that dead individuals may have become a significant part of the landscape, creating the conditions for the manipulation of the dead that led to the emergence of complex mortuary practices.

  20. The curvature of semidirect product groups associated with two-component Hunter-Saxton systems

    Energy Technology Data Exchange (ETDEWEB)

    Kohlmann, Martin, E-mail: kohlmann@ifam.uni-hannover.de [Institute for Applied Mathematics, University of Hannover, D-30167 Hannover (Germany)

    2011-06-03

    In this paper, we study two-component versions of the periodic Hunter-Saxton equation and its {mu}-variant. Considering both equations as a geodesic flow on the semidirect product of the circle diffeomorphism group Diff(S) with a space of scalar functions on S we show that both equations are locally well posed. The main result of this paper is that the sectional curvature associated with the 2HS is constant and positive and that 2{mu}HS allows for a large subspace of positive sectional curvature. The issues of this paper are related to some of the results for 2CH and 2DP presented in Escher et al (2011 J. Geom. Phys. 61 436-52).

  1. General medicine advanced training: lessons from the John Hunter training programme.

    Science.gov (United States)

    Jackel, D; Attia, J; Pickles, R

    2014-03-01

    Recent years have seen a rapid growth in the number of advanced trainees pursuing general medicine as a specialty. This reflects an awareness of the need for broader training experiences to equip future consultant physicians with the skills to manage the healthcare challenges arising from the demographic trends of ageing and increasing comorbidity. The John Hunter Hospital training programme in general medicine has several characteristics that have led to the success in producing general physicians prepared for these challenges. These include support from a core group of committed general physicians, an appropriate and sustainable funding model, flexibility with a focus on genuine training and developing awareness of a systems approach, and strong links with rural practice.

  2. Bounty Hunter x Alpha Industries 暗黑军事结合

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    日本里原系品牌找来正宗军服品牌Alpha Industries合作已不算新鲜事,早在1999年里原文化的黄金时期,差不多每到冬季总见不同类型的合作军褛款式,直到今年也不例外,而且一直延伸到春夏季。向来以朋克摇滚作设计方针的Bounty Hunter,在最新单品中再次找来Alpha Industries合作,推出以MA-1作蓝本的暗黑款式,并在细节上经过特别加工。

  3. Antibody responses against NY-ESO-1 and HER2 antigens in patients vaccinated with combinations of cholesteryl pullulan (CHP)-NY-ESO-1 and CHP-HER2 with OK-432.

    Science.gov (United States)

    Aoki, Masatoshi; Ueda, Shugo; Nishikawa, Hiroyoshi; Kitano, Shigehisa; Hirayama, Michiko; Ikeda, Hiroaki; Toyoda, Hideki; Tanaka, Kyosuke; Kanai, Michiyuki; Takabayashi, Arimichi; Imai, Hiroshi; Shiraishi, Taizo; Sato, Eiichi; Wada, Hisashi; Nakayama, Eiichi; Takei, Yoshiyuki; Katayama, Naoyuki; Shiku, Hiroshi; Kageyama, Shinichi

    2009-11-16

    Combination vaccines of the NY-ESO-1 protein complexed with cholesteryl pullulan (CHP), CHP-NY-ESO-1, and the truncated 146HER2 protein with CHP, CHP-HER2, were subcutaneously administered with the immuno-adjuvant OK-432 to eight esophageal cancer patients. Vaccination was well-tolerated. NY-ESO-1- and HER2-specific antibody responses were analyzed using the patients' sera and samples from previous single CHP-NY-ESO-1 or CHP-HER2 vaccine trial. The responses to NY-ESO-1 in the combination vaccine study were comparable to the single vaccine. For responses to HER2, there were fewer antibody responses in the combination vaccines. Although there were marked individual variations in the antibody responses to the NY-ESO-1 and HER2 antigens, the reaction patterns to these antigens were comparable within each patient. Antibodies to OK-432 were not augmented. Protein cancer vaccines targeting multiple antigens are feasible.

  4. Hepatitis E Virus in Domestic Pigs, Wild Boars, Pig Farm Workers, and Hunters in Estonia.

    Science.gov (United States)

    Ivanova, Anna; Tefanova, Valentina; Reshetnjak, Irina; Kuznetsova, Tatiana; Geller, Julia; Lundkvist, Åke; Janson, Marilin; Neare, Kädi; Velström, Kaisa; Jokelainen, Pikka; Lassen, Brian; Hütt, Pirje; Saar, Tiiu; Viltrop, Arvo; Golovljova, Irina

    2015-12-01

    While hepatitis E is a growing health concern in Europe, epidemiological data on hepatitis E virus (HEV) in Estonia are scarce. Along with imported HEV infections, autochthonous cases are reported from European countries. Both domestic and wild animals can be a source of human cases of this zoonosis. Here, we investigated the presence of anti-HEV antibodies and HEV RNA in domestic pigs and wild boars, as well as in pig farm workers and hunters in Estonia. Anti-HEV antibodies were detected in 234/380 (61.6%) of sera from domestic pigs and in all investigated herds, and in 81/471 (17.2%) of meat juice samples from wild boars. HEV RNA was detected by real-time PCR in 103/449 (22.9%) of fecal samples from younger domestic pigs and 13/81 (16.0%) of anti-HEV-positive wild boar samples. Analysis of sera from 67 pig farm workers and 144 hunters revealed the presence of HEV-specific IgG in 13.4 and 4.2% of the samples, respectively. No HEV RNA was detected in the human serum samples. Phylogenetic analyses of HEV sequences from domestic pigs and wild boars, based on a 245 bp fragment from the open reading frame 2 showed that all of them belonged to genotype 3. The present study demonstrates the presence of HEV in Estonian domestic pig and wild boar populations, as well as in humans who have direct regular contact with these animals. Our results suggest that HEV infections are present in Estonia and require attention.

  5. Trophy hunters' willingness to pay for wildlife conservation and community benefits.

    Science.gov (United States)

    Fischer, Anke; Tibebe Weldesemaet, Yitbarek; Czajkowski, Mikołaj; Tadie, Degu; Hanley, Nick

    2015-08-01

    In the face of fundamental land-use changes, the potential for trophy hunting to contribute to conservation is increasingly recognized. Trophy hunting can, for example, provide economic incentives to protect wildlife populations and their habitat, but empirical studies on these relationships are few and tend to focus on the effects of benefit-sharing schemes from an ex post perspective. We investigated the conditions under which trophy hunting could facilitate wildlife conservation in Ethiopia ex ante. We used a choice experiment approach to survey international trophy hunters' (n = 224) preferences for trips to Ethiopia, here operationalized as trade-offs between different attributes of a hunting package, as expressed through choices with an associated willingness to pay. Participants expressed strong preferences and, consequently, were willing to pay substantial premiums for hunting trips to areas with abundant nontarget wildlife where domestic livestock was absent and for arrangements that offered benefit sharing with local communities. For example, within the range of percentages considered in the survey, respondents were on average willing to pay an additional $3900 for every 10 percentage points of the revenue being given to local communities. By contrast, respondents were less supportive of hunting revenue being retained by governmental bodies: Willingness to pay decreased by $1900 for every 10 percentage points of the revenue given to government. Hunters' preferences for such attributes of hunting trips differed depending on the degree to which they declared an interest in Ethiopian culture, nature conservation, or believed Ethiopia to be politically unstable. Overall, respondents thus expressly valued the outcomes of nature conservation activities--the presence of wildlife in hunting areas--and they were willing to pay for them. Our findings highlight the usefulness of insights from choice modeling for the design of wildlife management and conservation

  6. Predicting hunter behavior of indigenous communities in the Ecuadorian Amazon: insights from a household production model

    Directory of Open Access Journals (Sweden)

    Enrique de la Montaña

    2015-12-01

    Full Text Available Many indigenous communities living in the Amazon rely on hunting and fishing to meet the majority of their protein needs. Despite the importance of these practices, few studies from the region have analyzed the socioeconomic drivers of hunting and fishing at the household level. We propose a household production model to assess the effect of key economic parameters on hunting and fishing in small indigenous communities located in the Ecuadorian Amazon, whose principal source of protein is derived from hunting and fishing. The model was validated using empirical data from two communities that reflect different levels of market integration and forest conservation. Demand and supply functions were generated from household data gathered over 19 months. Elasticities were derived to determine the sensitivity of the decision to engage in hunting to exogenous parameters such as off-farm wages, hunting costs, bushmeat price, penalties for the illegal sale of bushmeat, and biological characteristics of the game species. After calibrating the model, we simulated changes in the key economic parameters. The parameter that most directly affected hunting activity in both communities was off-farm wages. Simulating a 10% wage increase resulted in a 16-20% reduction in harvested biomass, while a 50% increase diminished harvested biomass by > 50%. Model simulations revealed that bushmeat price and penalties for illegal trade also had important effects on hunter behavior in terms of amount of bushmeat sold, but not in terms of total harvest. As a tool for understanding hunters' economic decision-making, the model provides a basis for developing strategies that promote sustainable hunting and wildlife conservation while protecting indigenous livelihoods.

  7. Measured elemental transfer factors for boreal hunter/gatherer scenarios: fish, game and berries.

    Science.gov (United States)

    Sheppard, S C; Long, J M; Sanipelli, B

    2010-11-01

    The environmental assessment of long-term nuclear waste management requires data to estimate food chain transfers for radionuclides in various environmental settings. For key elements such as iodine (I) and chlorine (Cl), there is a paucity of transfer factor data, particularly outside of agricultural food chains. This study dealt with transfers of I, Cl and 28 other elements to foods that would be typical of boreal hunter/gatherer lifestyles, as well as being common foods for modern recreational and subsistence hunters. Food/substrate concentration ratios (CRs) and related transfer factors for eight species of widely distributed fish, whitetail deer (Odocoileus virginianus), Canada geese (Branta canadensis) and wild blueberries (Vaccinium myrtilloides) were measured and compared to the literature. Limited data were obtained for caribou (Rangifer tarandus), elk (Cervus elaphus) and moose (Alces americanus). Freshwater sediment Kd values and CRs for a ubiquitous freshwater macrophyte were also obtained. The CRs for I in fish were 29Lkg(-1) in edible muscle (fillets) of large-bodied species and 85Lkg(-1) for whole, small-bodied fish. The logCRs for fish and macrophytes were correlated across elements. For several elements, the Kds for sediments in deep water were approximately 4-fold higher than for littoral samples. The elemental transfers to wild animals for some elements were notably different than the literature indicates for domestic animals. It is argued that the transfer data obtained using indigenous elements from real environmental settings, as opposed to contaminant elements in experimental or impacted environments, are especially relevant to assessment of long-term impacts.

  8. Enzymatic replacement therapy for Hunter disease: Up to 9 years experience with 17 patients

    Directory of Open Access Journals (Sweden)

    Rossella Parini

    2015-06-01

    Full Text Available Hunter disease is an X-linked lysosomal storage disorder characterized by progressive storage of glycosaminoglycans (GAGs and multi-organ impairment. The central nervous system (CNS is involved in at least 50% of cases. Since 2006, the enzymatic replacement therapy (ERT is available but with no effect on the cognitive impairment, as the present formulation does not cross the blood–brain barrier. Here we report the outcome of 17 Hunter patients treated in a single center. Most of them (11 started ERT in 2006, 3 had started it earlier in 2004, enrolled in the phase III trial, and 3 after 2006, as soon as the diagnosis was made. The liver and spleen sizes and urinary GAGs significantly decreased and normalized throughout the treatment. Heart parameters improved, in particular the left ventricular mass index/m2 decreased significantly. Amelioration of hearing was seen in many patients. Joint range of motion improved in all patients. However, no improvement on respiratory function, eye, skeletal and CNS disease was found. The developmental quotient of patients with a CNS involvement showed a fast decline. These patients were no more testable after 6 years of age and, albeit the benefits drawn from ERT, their quality of life worsened throughout the years. The whole group of patients showed a consistent residual disease burden mainly represented by persistent skeletal disease and frequent need of surgery. This study suggests that early diagnosis and treatment and other different therapies which are able to cross the blood–brain barrier, might in the future improve the MPS II outcome.

  9. Brood surveys and hunter observations used to predict gobbling activity wild turkeys in Mississippi

    Science.gov (United States)

    Palumbo, Matthew D.; Vilella, Francisco; Strickland, Bronson K.; Wang, Guiming; Godwin, Dave

    2014-01-01

    The Mississippi Department of Wildlife, Fisheries, and Parks utilize data from turkey hunter observations and brood surveys from across the state to manage wild turkey Meleagris gallopavo populations. Since 1995, hunters have collected gobbling and jake observation data, while the Mississippi Department of Wildlife, Fisheries, and Parks' personnel and cooperating wildlife managers of several natural resource agencies throughout the state have collected brood survey data. Both sources of data serve to forecast poult recruitment and gobbling activity. The objective of this study was to evaluate if these data can serve as a viable predictor of gobbling activity. We used three mixed models to investigate the relationship between the number of jakes observed per hour of hunting 1 y prior and the total number of poults per hens 2 y prior (model 1), number of gobblers heard per hour of hunting and the number of jakes observed per hour of hunting 1 y prior (model 2), the number of gobblers heard per hour of hunting and the total number poults per total hens observed 2 y prior (model 3) using data from 1995 to 2008 among five wild turkey management regions encompassing the state. We incorporated region as a random effect to account for spatial variation. We found the number of jakes observed per hour of hunting 1 y prior correlated with the total number of poults per total hens observed 2 y prior. We also found the number of gobblers heard per hour of hunting correlated with the number of jakes observed per hour of hunting 1 y prior. Additionally, we found that the total poults per total hens observed 2 y prior was correlated to the number of gobblers heard per hour of hunting. Our results show promise for using indices of gobbling activity, jake observations, and brood surveys to estimate gobbling activity.

  10. NY-ESO-1 expression in meningioma suggests a rationale for new immunotherapeutic approaches.

    Science.gov (United States)

    Baia, Gilson S; Caballero, Otavia L; Ho, Janelle S Y; Zhao, Qi; Cohen, Tzeela; Binder, Zev A; Salmasi, Vafi; Gallia, Gary L; Quinones-Hinojosa, Alfredo; Olivi, Alessandro; Brem, Henry; Burger, Peter; Strausberg, Robert L; Simpson, Andrew J G; Eberhart, Charles G; Riggins, Gregory J

    2013-11-01

    Meningiomas are the most common primary intracranial tumors. Surgical resection remains the treatment of choice for these tumors. However, a significant number of tumors are not surgically accessible, recur, or become malignant, necessitating the repetition of surgery and sometimes radiation. Chemotherapy is rarely used and is generally not recognized as an effective treatment. Cancer/testis (CT) genes represent a unique class of genes, which are expressed by germ cells, normally silenced in somatic cells, but activated in various cancers. CT proteins can elicit spontaneous immune responses in patients with cancer and this feature makes them attractive targets for immunotherapy-based approaches. We analyzed mRNA expression of 37 testis-restricted CT genes in a discovery set of 18 meningiomas by reverse transcription PCR. The overall frequency of expression of CT genes ranged from 5.6% to 27.8%. The most frequently expressed was NY-ESO-1, in 5 patients (27.8%). We subsequently analyzed NY-ESO-1 protein expression in a larger set of meningiomas by immunohistochemistry and found expression in 108 of 110 cases. In some cases, NY-ESO-1 expression was diffused and homogenous, but in most instances it was heterogeneous. Importantly, NY-ESO-1 expression was positively correlated with higher grade and patients presenting with higher levels of NY-ESO-1 staining had significantly worse disease-free and overall survival. We have also shown that NY-ESO-1 expression may lead to humoral immune response in patients with meningioma. Considering the limited treatment options for patients with meningioma, the potential of NY-ESO-1-based immunotherapy should be explored. ©2013 AACR.

  11. Efficacy of systemic adoptive transfer immunotherapy targeting NY-ESO-1 for glioblastoma.

    Science.gov (United States)

    Everson, Richard G; Antonios, Joseph P; Lisiero, Dominique N; Soto, Horacio; Scharnweber, Rudi; Garrett, Matthew C; Yong, William H; Li, Ning; Li, Gang; Kruse, Carol A; Liau, Linda M; Prins, Robert M

    2016-03-01

    Immunotherapy is an ideal treatment modality to specifically target the diffusely infiltrative tumor cells of malignant gliomas while sparing the normal brain parenchyma. However, progress in the development of these therapies for glioblastoma has been slow due to the lack of immunogenic antigen targets that are expressed uniformly and selectively by gliomas. We utilized human glioblastoma cell cultures to induce expression of New York-esophageal squamous cell carcinoma (NY-ESO-1) following in vitro treatment with the demethylating agent decitabine. We then investigated the phenotype of lymphocytes specific for NY-ESO-1 using flow cytometry analysis and cytotoxicity against cells treated with decitabine using the xCelligence real-time cytotoxicity assay. Finally, we examined the in vivo application of this immune therapy using an intracranially implanted xenograft model for in situ T cell trafficking, survival, and tissue studies. Our studies showed that treatment of intracranial glioma-bearing mice with decitabine reliably and consistently induced the expression of an immunogenic tumor-rejection antigen, NY-ESO-1, specifically in glioma cells and not in normal brain tissue. The upregulation of NY-ESO-1 by intracranial gliomas was associated with the migration of adoptively transferred NY-ESO-1-specific lymphocytes along white matter tracts to these tumors in the brain. Similarly, NY-ESO-1-specific adoptive T cell therapy demonstrated antitumor activity after decitabine treatment and conferred a highly significant survival benefit to mice bearing established intracranial human glioma xenografts. Transfer of NY-ESO-1-specific T cells systemically was superior to intracranial administration and resulted in significantly extended and long-term survival of animals. These results reveal an innovative, clinically feasible strategy for the treatment of glioblastoma. © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro

  12. Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination.

    Science.gov (United States)

    Kawada, Junji; Wada, Hisashi; Isobe, Midori; Gnjatic, Sacha; Nishikawa, Hiroyoshi; Jungbluth, Achim A; Okazaki, Nami; Uenaka, Akiko; Nakamura, Yurika; Fujiwara, Shinichi; Mizuno, Naoaki; Saika, Takashi; Ritter, Erika; Yamasaki, Makoto; Miyata, Hiroshi; Ritter, Gerd; Murphy, Roger; Venhaus, Ralph; Pan, Linda; Old, Lloyd J; Doki, Yuichiro; Nakayama, Eiichi

    2012-02-01

    NY-ESO-1 is a prototypic cancer/testis antigen. In a recent phase I clinical trial, we vaccinated 13 patients bearing NY-ESO-1-expressing tumors with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein (CHP-NY-ESO-1) and showed efficient induction of NY-ESO-1 antibody, and CD4 and CD8 T cell responses using peripheral blood from the patients. In our study, we analyzed heteroclitic serological responses in those patients after vaccination. Serological response against 11 tumor antigens including MAGE-A1, MAGE-A3, MAGE-A4, CT7/MAGEC1, CT10/MAGEC2, CT45, CT46/HORMAD1, SOX2, SSX2, XAGE1B and p53 was examined by enzyme-linked immunosorbent assay (ELISA) using sera from ten vaccinated patients. Expression of tumor antigens was determined by reverse transcription-polymerase chain reaction or immunohistochemistry. Eight of nine patients who showed antibody responses against NY-ESO-1 also showed an antibody response against at least 1 of these 11 tumor antigens after vaccination. In one patient, seven tumor antigens were recognized. Specificity analysis of the antibody response by ELISA using control recombinant proteins and synthetic peptides and by Western blot showed that the response was not against His6-tag and/or bacterial products included in a preparation of CHP-NY-ESO-1 used for vaccination. Thus, heteroclitic serological responses appear to be indicative of the overall immune response against the tumor, and their analysis could be useful for immune monitoring in cancer vaccine. Copyright © 2011 UICC.

  13. Attitudes and Beliefs of Pig Farmers and Wild Boar Hunters Towards Reporting of African Swine Fever in Bulgaria, Germany and the Western Part of the Russian Federation.

    Science.gov (United States)

    Vergne, T; Guinat, C; Petkova, P; Gogin, A; Kolbasov, D; Blome, S; Molia, S; Pinto Ferreira, J; Wieland, B; Nathues, H; Pfeiffer, D U

    2016-04-01

    This study investigated the attitudes and beliefs of pig farmers and hunters in Germany, Bulgaria and the western part of the Russian Federation towards reporting suspected cases of African swine fever (ASF). Data were collected using a web-based questionnaire survey targeting pig farmers and hunters in these three study areas. Separate multivariable logistic regression models identified key variables associated with each of the three binary outcome variables whether or not farmers would immediately report suspected cases of ASF, whether or not hunters would submit samples from hunted wild boar for diagnostic testing and whether or not hunters would report wild boar carcasses. The results showed that farmers who would not immediately report suspected cases of ASF are more likely to believe that their reputation in the local community would be adversely affected if they were to report it, that they can control the outbreak themselves without the involvement of veterinary services and that laboratory confirmation would take too long. The modelling also indicated that hunters who did not usually submit samples of their harvested wild boar for ASF diagnosis, and hunters who did not report wild boar carcasses are more likely to justify their behaviour through a lack of awareness of the possibility of reporting. These findings emphasize the need to develop more effective communication strategies targeted at pig farmers and hunters about the disease, its epidemiology, consequences and control methods, to increase the likelihood of early reporting, especially in the Russian Federation where the virus circulates.

  14. CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit.

    Science.gov (United States)

    Yuan, Jianda; Gnjatic, Sacha; Li, Hao; Powel, Sarah; Gallardo, Humilidad F; Ritter, Erika; Ku, Geoffrey Y; Jungbluth, Achim A; Segal, Neil H; Rasalan, Teresa S; Manukian, Gregor; Xu, Yinyan; Roman, Ruth-Ann; Terzulli, Stephanie L; Heywood, Melanie; Pogoriler, Evelina; Ritter, Gerd; Old, Lloyd J; Allison, James P; Wolchok, Jedd D

    2008-12-23

    Blockade of inhibitory signals mediated by cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) has been shown to enhance T cell responses and induce durable clinical responses in patients with metastatic melanoma. The functional impact of anti-CTLA-4 therapy on human immune responses is still unclear. To explore this, we analyzed immune-related adverse events and immune responses in metastatic melanoma patients treated with ipilimumab, a fully human anti-CTLA-4 monoclonal antibody. Fifteen patients were selected on the basis of availability of suitable specimens for immunologic monitoring, and eight of these showed evidence of clinical benefit. Five of the eight patients with evidence of clinical benefit had NY-ESO-1 antibody, whereas none of seven clinical non-responders was seropositive for NY-ESO-1. All five NY-ESO-1 seropositive patients had clearly detectable CD4(+) and CD8(+) T cells against NY-ESO-1 following treatment with ipilimumab. One NY-ESO-1 seronegative clinical responder also had a NY-ESO-1 CD4(+) and CD8(+) T cell response, possibly related to prior vaccination with NY-ESO-1. Among five clinical non-responders analyzed, only one had a NY-ESO-1 CD4(+) T cell response and this patient did not have detectable anti-NY-ESO-1 antibody. Overall, NY-ESO-1-specific T cell responses increased in frequency and functionality during anti-CTLA-4 treatment, revealing a polyfunctional response pattern of IFN-gamma, MIP-1beta and TNF-alpha. We therefore suggest that CTLA-4 blockade enhanced NY-ESO-1 antigen-specific B cell and T cell immune responses in patients with durable objective clinical responses and stable disease. These data provide an immunologic rationale for the efficacy of anti-CTLA-4 therapy and call for immunotherapeutic designs that combine NY-ESO-1 vaccination with CTLA-4 blockade.

  15. The distribution of depleted uranium contamination in Colonie, NY, USA

    Energy Technology Data Exchange (ETDEWEB)

    Lloyd, N.S., E-mail: nsl3@alumni.leicester.ac.uk [Department of Geology, University of Leicester, University Road, Leicester, LE1 7RH (United Kingdom); Chenery, S.R.N. [British Geological Survey, Kingsley Dunham Centre, Keyworth, Nottingham, NG12 5GG (United Kingdom); Parrish, R.R. [Department of Geology, University of Leicester, University Road, Leicester, LE1 7RH (United Kingdom); NERC Isotope Geosciences Laboratory, Kingsley Dunham Centre, Keyworth, Nottingham, NG12 5GG (United Kingdom)

    2009-12-20

    Uranium oxide particles were dispersed into the environment from a factory in Colonie (NY, USA) by prevailing winds during the 1960s and '70s. Uranium concentrations and isotope ratios from bulk soil samples have been accurately measured using inductively coupled plasma quadrupole mass spectrometry (ICP-QMS) without the need for analyte separation chemistry. The natural range of uranium concentrations in the Colonie soils has been estimated as 0.7-2.1 {mu}g g{sup -1}, with a weighted geometric mean of 1.05 {mu}g g{sup -1}; the contaminated soil samples comprise uranium up to 500 {+-} 40 {mu}g g{sup -1}. A plot of {sup 236}U/{sup 238}U against {sup 235}U/{sup 238}U isotope ratios describes a mixing line between natural uranium and depleted uranium (DU) in bulk soil samples; scatter from this line can be accounted for by heterogeneity in the DU particulate. The end-member of DU compositions aggregated in these bulk samples comprises (2.05 {+-} 0.06) x 10{sup -3235}U/{sup 238}U, (3.2 {+-} 0.1) x 10{sup -5236}U/{sup 238}U, and (7.1 {+-} 0.3) x 10{sup -6234}U/{sup 238}U. The analytical method is sensitive to as little as 50 ng g{sup -1} DU mixed with the natural uranium occurring in these soils. The contamination footprint has been mapped northward from site, and at least one third of the uranium in a soil sample from the surface 5 cm, collected 5.1 km NNW of the site, is DU. The distribution of contamination within the surface soil horizon follows a trend of exponential decrease with depth, which can be approximated by a simple diffusion model. Bioturbation by earthworms can account for dispersal of contaminant from the soil surface, in the form of primary uranium oxide particulates, and uranyl species that are adsorbed to organic matter. Considering this distribution, the total mass of uranium contamination emitted from the factory is estimated to be c. 4.8 tonnes.

  16. Partnership to Enhance Diversity in Marine Geosciences: Holocene Climate and Anthorpogenic Changes from Long Island Sound, NY

    Science.gov (United States)

    McHugh, C. M.; Cormier, M.; Marchese, P.; Zheng, Y.; Kohfeld, K.

    2006-12-01

    assistance to attend college; and 3) through our regular teaching schedule for non-geoscience majors. The PIs work at four different institutions from NY metropolitan area: 1) Queens College (QC) from the City University of New York (CUNY.); 2) Queensborough Community College (CUNY), a minority serving college; 3) Lehman College (CUNY), a minority serving college; and 4) Lamont-Doherty Earth Observatory (LDEO), a world-class earth science research institution. External financial support for the program has been secured through the City University of New York Graduate Center through a MAGNET fellowship, Minorities Striving and Pursuing Higher Degrees of Success in Earth Systems Science Professional Development Program 2006, through two industry grants (Entergy Co. and NRG Energy), and in the future, through the availability at competitive rates of local research vessels for day- trips. We anticipate that the program will further gain momentum through partnerships with other City University of New York senior and community colleges, and thanks to word of mouth from those students who participated in the program.

  17. Hide Tanning and Its Use in Taiga: The Case of the Orochen-Evenki Reindeer Herders and Hunters of Zabaikalye (East Siberia

    Directory of Open Access Journals (Sweden)

    Donatas Brandišauskas

    2010-12-01

    Full Text Available This article documents the way in which the Orochen-Evenki hunters and herders in northern part of Zabaikalye tan hides and produce gear in the post-Soviet era. Here, I wish to present the argument that it is difficult to understand the reviving of hide tanning in remote villages and the taiga without understanding how hunters and herders in this region adapt to the unstable post-Soviet environment. I suggest that hunters and herders aim to maintain their autonomy from goods and resources imported from cities, and, in spending little effort connecting with state powers in this way, securing their lives from socio-economic constraints.

  18. NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery

    OpenAIRE

    Xu, Heng; GU, NA; LIU, ZHAO-BO; Zheng, Min; Xiong, Fang; WANG, SI-YING; Li, Ning; Lu, Jun

    2011-01-01

    NY-ESO-1 belongs to the cancer testis antigens (CTA) family, and is identified in a variety of tumors. Certain studies have demonstrated that NY-ESO-1 predicts tumor recurrence and treatment response. No reports are currently available regarding the correlation between NY-ESO-1 and the recurrence of hepatocellular carcinoma (HCC) following surgery. The purpose of the present study was to evaluate the association between NY-ESO-1 and relapse of HCC and to explore the possible mechanisms for th...

  19. NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery

    OpenAIRE

    2011-01-01

    NY-ESO-1 belongs to the cancer testis antigens (CTA) family, and is identified in a variety of tumors. Certain studies have demonstrated that NY-ESO-1 predicts tumor recurrence and treatment response. No reports are currently available regarding the correlation between NY-ESO-1 and the recurrence of hepatocellular carcinoma (HCC) following surgery. The purpose of the present study was to evaluate the association between NY-ESO-1 and relapse of HCC and to explore the possible mechanisms for th...

  20. Estimation of an NY-ESO-1 expressing HCC cell line by NY-ESO-1b specific CD8+T cells in vitro induced by HLA-A2 restricted NY-ESO-1b peptide%HLA-A2限制性NY-ESO-1b肽段诱导的CD8+ T细胞对稳定表达NY-ESO-1的HepG2肝癌细胞系的杀伤效应

    Institute of Scientific and Technical Information of China (English)

    乔欢; 钱晓萍; 张华刚; 田婵; 陈慰峰

    2005-01-01

    目的:分析体外诱导的NY-ESO-1特异性杀伤性T淋巴细胞对稳定表达NY-ESO-1蛋白的肝细胞性肝癌(hepatocellular carcinoma,HCC)细胞系的杀伤效应,为进一步分析NY-ESO-1蛋白作为疫苗用于治疗HCC的可能性提供实验支持.方法:从HLA-A2阳性的肝癌患者体内分离出外周血单个核细胞,用NY-ESO-1肽段体外诱导特异性杀伤性T淋巴细胞,并通过酶联免疫斑点法分析特异性杀伤性T淋巴细胞对稳定表达NY-ESO-1蛋白的HCC细胞系HepG2细胞的杀伤效应.结果:转染了NY-ESO-1的HepG2细胞(HLA-A2+)可有效地被NY-ESO-1157-165抗原肽诱导的特异性CD8+ T淋巴细胞所识别.效应细胞中大量GrB的释放表明其对稳定转染了NY-ESO-1基因的HepG2细胞有很强的杀伤作用.结论:HepG2细胞中表达的NY-ESO-1蛋白可被此肝癌细胞有效地加工处理,而且HLA-A2限制性的抗原肽NY-ESO-1157-165也可被有效地提呈到细胞表面,从而被效应T细胞所识别.

  1. Middle Permian palaeobiogeography study in East Kunlun, A'nyêmaqên and Bayan Har

    Institute of Scientific and Technical Information of China (English)

    WANG; Yongbiao; YANG; Hao

    2004-01-01

    Three regions can easily be identified in the study area according to the Middle Permian palaeobiogeographic distribution of biota, they are the southern slope of East Kunlun, A'nyêmaqên and Bayan Har. Biotic constitution and ecology in the southern slope of East Kunlun and Bayan Har are very similar. Both the diversity and abundance of organisms in these two areas are very high and reefs are widely developed. However, biotic diversity and abundance in A'nyêmaqên which is between the above two areas are obviously low. Differentiation of palaeobiogeographic distribution in these areas should be due to the baring of A'nyêmaqên ocean in the time of Middle Permian. Middle Permian radiolarian chert and thick abyssal red ooze are widely spread in A'nyêmaqên, implying that the A'nyêmaqên ocean had a great scale in size. Vast scale of deep ocean basin became an impassable gulf for some of the benthos, and as a result, only part of the organisms could have the chance to get to the isolated islands situated in ocean basin. Small living space and hard conditions in the islands further limited the abundance and diversity of biota. Tectonic background reflected by the geochemical study of basalt in the three areas is coupling well enough with the palaeobiogeographic division.

  2. Short-term Climate Characteristics at Ny-(A)lesund over the Arctic Tundra Area

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Based on the Germany Koldwey Station's 1994-2003 conventional observation hourly data, this paper conducts a statistical analysis on the short-term climate characteristics for an arctic tundra region (Ny-(A)lesund island) where our first arctic expedition station (Huanghe Station) was located. Affected by the North Atlantic warming current, this area has a humid temperate climate, and the air temperature at Ny-(A)lesund rose above 0 ℃ even during deep winter season during our research period. The wind speed in this area was low and appeared most at southeast direction. We find that the temperature at Ny-(A)lesund rose in the faster rate (0.68 ℃/10 a) than those at the whole Arctic area. Compared with the floating ices where our expedition conducted in the Arctic, Ny-(A)lesund was warmer and more humid and had lower wind speed. Comparison of the near surface air temperature derived by NCEP/NCAR reanalysis to the conventional measurements conducted at the Koldwey site in Ny-(A)lesund area shows a good agreement for winter season and a significant difference for summer season.

  3. A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen.

    Science.gov (United States)

    Kakimi, Kazuhiro; Isobe, Midori; Uenaka, Akiko; Wada, Hisashi; Sato, Eiichi; Doki, Yuichiro; Nakajima, Jun; Seto, Yasuyuki; Yamatsuji, Tomoki; Naomoto, Yoshio; Shiraishi, Kenshiro; Takigawa, Nagio; Kiura, Katsuyuki; Tsuji, Kazuhide; Iwatsuki, Keiji; Oka, Mikio; Pan, Linda; Hoffman, Eric W; Old, Lloyd J; Nakayama, Eiichi

    2011-12-15

    We conducted a phase I clinical trial of a cancer vaccine using a 20-mer NY-ESO-1f peptide (NY-ESO-1 91-110) that includes multiple epitopes recognized by antibodies, and CD4 and CD8 T cells. Ten patients were immunized with 600 μg of NY-ESO-1f peptide mixed with 0.2 KE Picibanil OK-432 and 1.25 ml Montanide ISA-51. Primary end points of the study were safety and immune response. Subcutaneous injection of the NY-ESO-1f peptide vaccine was well tolerated. Vaccine-related adverse events observed were fever (Grade 1), injection-site reaction (Grade 1 or 2) and induration (Grade 2). Vaccination with the NY-ESO-1f peptide resulted in an increase or induction of NY-ESO-1 antibody responses in nine of ten patients. The sera reacted with recombinant NY-ESO-1 whole protein as well as the NY-ESO-1f peptide. An increase in CD4 and CD8 T cell responses was observed in nine of ten patients. Vaccine-induced CD4 and CD8 T cells responded to NY-ESO-1 91-108 in all patients with various HLA types with a less frequent response to neighboring peptides. The findings indicate that the 20-mer NY-ESO-1f peptide includes multiple epitopes recognized by CD4 and CD8 T cells with distinct specificity. Of ten patients, two with lung cancer and one with esophageal cancer showed stable disease. Our study shows that the NY-ESO-1f peptide vaccine was well tolerated and elicited humoral, CD4 and CD8 T cell responses in immunized patients. Copyright © 2011 UICC.

  4. Comet Hunters: A Citizen Science Project to Search for Comets in the Main Asteroid Belt

    Science.gov (United States)

    Hsieh, Henry H.; Schwamb, Megan Elizabeth; Zhang, Zhi-Wei; Chen, Ying-Tung; Wang, Shiang-Yu; Lintott, Chris

    2016-10-01

    Fully automated detection of comets in wide-field surveys remains a challenge, as even highly successful comet-finding surveys like Pan-STARRS rely on a combination of both automated flagging algorithms and vetting by human eyes. To take advantage of the long-noted superiority of the human eye over computer algorithms in certain types of pattern recognition, particularly when dealing with a range of target morphologies of interest, we have created a citizen science website with the aim of allowing the general public to aid in the search for active asteroids, which are objects that occupy dynamically asteroidal orbits yet exhibit comet-like dust emission due to sublimation, impact disruption, rotational destabilization, or other effects. Located at comethunters.org, the Comet Hunters website was built using the Zooniverse Project Builder (https://www.zooniverse.org/lab), and displays images of known asteroids obtained either from archival data obtained between 1999 and 2014 by the Suprime-Cam wide-field imager mounted on the 8-m Subaru telescope on Mauna Kea in Hawaii, or more contemporary data obtained by the Hyper Suprime-Cam (HSC) wide-field imager also on the Subaru Telescope as part of the ongoing HSC Subaru Strategic Program (SSP) survey. By using observations from such a large-aperture telescope, most of which have never been searched for solar system objects, much less cometary ones, we expect that volunteers should be able to make genuinely scientifically significant discoveries, and also provide valuable insights into the potential and challenges of searching for comets in the LSST era. To date, over 13,000 registered volunteers have contributed 350,000 classifications. We will discuss the design and construction of the Comet Hunters website, and also discuss early results from the project.This work uses data generated via the Zooniverse.org platform, development of which was supported by a Global Impact Award from Google, and by the Alfred P. Sloan

  5. Mount Pinatubo, inflammatory cytokines, and the immunological ecology of Aeta hunter-gatherers.

    Science.gov (United States)

    Bernstein, Robin M; Dominy, Nathaniel J

    2013-01-01

    Early growth cessation and reproduction are predicted to maximize fitness under conditions of high adult mortality, factors that could explain the pygmy phenotype of many rainforest hunter-gatherers. This life-history hypothesis is elegant but contentious in part because it lacks a clear biological mechanism. One mechanism stems from the field of human immunological ecology and the concept of inflammation "memory" across the life cycle and into subsequent generations. Maternal exposures to disease can influence immunological cues present in breast milk; because maternal provisioning via lactation occurs during critical periods of development, it is plausible that these cues can also mediate early growth cessation and small body size. Such epigenetic hypotheses are difficult to test, but the concept of developmental programming is attractive because it could explain how the stature of a population can change over time, in terms of both secular increases and rapid intergenerational decreases. Here we explore this concept by focusing on the Aeta, a population of former hunter-gatherers, and the Ilocano, a population of rice farmers. We predicted that Aeta mothers would produce breast milk with higher concentrations of four bioactive factors due to high infectious burdens. Further, we predicted that the concentrations of these factors would be highest in the cohort of women born in the early 1990s, when exposure to infectious disease was acute following the eruption of Mount Pinatubo in June 1991. We analyzed levels of adiponectin, C-reactive protein, and epidermal growth factor in the milk of 24 Aeta and 31 Ilocano women and found no detectable differences, whereas levels of transforming growth factor-?2 were elevated among the Aeta, particularly as a function of maternal age. We found no difference between cohorts divided by the volcanic eruption (n = 43 born before, n = 12 born after). We discuss the implications of our findings for the terminal investment

  6. Macrophysical climate models and Holocene hunter-gatherer subsistence shifts in Central Texas, USA

    Science.gov (United States)

    Mauldin, R. P.; Munoz, C.

    2013-12-01

    We use stable carbon isotopic values from bone collagen, as well as carbon values from carbonate extracted from bone apatite from 69 prehistoric human skeletal samples to investigate past resource use and climate relationships over the Middle and Late Holocene in Central Texas. Bone samples come from seven archaeological sites and samples date from 6,900 BP to the close of the prehistoric sequence at about 350 BP. Carbon isotopes from these samples suggest four broad dietary trends. From 6,900 through about 3,800 BP, carbon isotopes suggest a gradual increase in the consumption of resources that ultimately use a C3 photosynthetic pathway. A decline in δ13C in both collagen and carbonate values follows, suggesting a decrease in C3 resource use through roughly 2,900 BP. A variable, but once again increasing pattern on C3 resource use by prehistoric hunter-gatherers is indicated in bone isotopes through about 1,000 BP. After that date, a decrease in C3 resource dependence, with hints at greater subsistence diversity, is suggested through the close of the sequence at 350 BP. To assess the impact of climate shifts on this isotopic pattern, we developed a series of macrophysical climate models (MCM) for several locations in Central Texas focusing on fall, winter, and early spring precipitation. This fall-spring rainfall should closely determine C3 production. If subsistence shifts are responding to climate-induced changes in resource availability, then the measured hunter-gatherer carbon isotope trends summarized above should pattern with C3 production as monitored by the modeled fall-spring precipitation values. For the Middle Holocene portion of the sequence, the precipitation models suggest increasing C3 production, consistent with increasing C3 dependence shown in the isotopic data. A decline in C3 production between 3,900 and 3,000 BP in the models is also consistent with the isotopic decline at that point. After 3,000 BP, however, the coupling between fall

  7. Moral Bargain Hunters Purchase Moral Righteousness When it is Cheap: Within-Individual Effect of Stake Size in Economic Games.

    Science.gov (United States)

    Yamagishi, Toshio; Li, Yang; Matsumoto, Yoshie; Kiyonari, Toko

    2016-06-14

    Despite the repeatedly raised criticism that findings in economic games are specific to situations involving trivial incentives, most studies that have examined the stake-size effect have failed to find a strong effect. Using three prisoner's dilemma experiments, involving 479 non-student residents of suburban Tokyo and 162 students, we show here that stake size strongly affects a player's cooperation choices in prisoner's dilemma games when stake size is manipulated within each individual such that each player faces different stake sizes. Participants cooperated at a higher rate when stakes were lower than when they were higher, regardless of the absolute stake size. These findings suggest that participants were 'moral bargain hunters' who purchased moral righteousness at a low price when they were provided with a 'price list' of prosocial behaviours. In addition, the moral bargain hunters who cooperated at a lower stake but not at a higher stake did not cooperate in a single-stake one-shot game.

  8. Sharing Our Teachers: The Required Graduate Class at the American Museum of Natural History for Lehman College (CUNY)

    Science.gov (United States)

    Aquino, Adriana E.; Kelly, Angela M.; Bayne, Gillian U.

    2010-01-01

    This reflective study explores the history and outcomes of a teacher education collaboration between the American Museum of Natural History (AMNH) and Lehman College of The City University of New York (CUNY), in the Bronx, NY, USA. AMNH developed and teaches a Lehman course, Museum Resources for Teaching Science, for Master's degree candidates in…

  9. 铜绿假单胞菌NY3所产表面活性剂对原油降解的影响%Effects of rhamnolipid on oil degradation by Pseudomonas aeruginosa strain NY3

    Institute of Scientific and Technical Information of China (English)

    常虹; 蒋欣; 聂麦茜; 葛碧洲; 刘超; 杨琴; 周立辉; 樊晓宇; 孙超; 韦绒绒

    2013-01-01

    铜绿假单胞菌NY3是从石油污染土壤中分离出的一株能快速代谢疏水性化合物的菌种.研究了该菌产表面活性剂及对原油降解的作用.实验表明,在敞开体系中,投加82 mg/L NY3菌产的鼠李糖脂,240 h能使NY3对原油的降解率提高50%.投加甘油使NY3产鼠李糖脂与降解原油同步进行,与投加鼠李糖脂对原油降解的促进作用相近.投加9%甘油使NY3在168 h对原油的降解率提高43%.NY3菌能同时降解原油中的直链烷烃及菲(Pr)和芘(Ph)等多环芳烃.在敞开体系中用少量甘油使产鼠李糖脂和降解原油同步进行,节约处理费用.研究结果为NY3菌株在露天石油污染环境修复中的应用奠定了基础.%Pseudomonas aeruginosa NY3 , being able to metabolize hydrophobic compounds, was isolated from petroleum-contaminated soil samples. Effects of the rhamnolipid and its production on crude oil degradation by NY3 strain were discussed. The results showed that the rhamnolipid produced by NY3 strain could enhance crude oil biodegradation. Comparing with the controls, oil removal rate within 240 h enhanced 50% with 82 mg/ L rhamnolipid. Adding glycerol in NY3 degrading systems, the degradation of crude oil and the rhamnolipid production took place simultaneously, the instantly produced rhamnolipid also accelerated oil metabolism. Adding 9‰ glycerol, the crude oil removal rate by NY3 improved about 43% within 168 h. Phenanthrene (Ph) and py-rene ( Pr) containing in the crude oil could also be removed. The cost of the remediation of contaminated water body by NY3 strain can be decreased by using small amount of glycerol, instead of using rhamnolipid directly. The above results lay a foundation for NY3 strain applying to oil-spill clean-up.

  10. College Health

    Science.gov (United States)

    College life involves excitement, along with new challenges, risks, and responsibilities. You are meeting new people, learning ... stay healthy and safe while you're in college: Eat a balanced diet Get enough sleep Get ...

  11. AllerHunter: a SVM-pairwise system for assessment of allergenicity and allergic cross-reactivity in proteins.

    Science.gov (United States)

    Muh, Hon Cheng; Tong, Joo Chuan; Tammi, Martti T

    2009-06-10

    Allergy is a major health problem in industrialized countries. The number of transgenic food crops is growing rapidly creating the need for allergenicity assessment before they are introduced into human food chain. While existing bioinformatic methods have achieved good accuracies for highly conserved sequences, the discrimination of allergens and non-allergens from allergen-like non-allergen sequences remains difficult. We describe AllerHunter, a web-based computational system for the assessment of potential allergenicity and allergic cross-reactivity in proteins. It combines an iterative pairwise sequence similarity encoding scheme with SVM as the discriminating engine. The pairwise vectorization framework allows the system to model essential features in allergens that are involved in cross-reactivity, but not limited to distinct sets of physicochemical properties. The system was rigorously trained and tested using 1,356 known allergen and 13,449 putative non-allergen sequences. Extensive testing was performed for validation of the prediction models. The system is effective for distinguishing allergens and non-allergens from allergen-like non-allergen sequences. Testing results showed that AllerHunter, with a sensitivity of 83.4% and specificity of 96.4% (accuracy = 95.3%, area under the receiver operating characteristic curve AROC = 0.928+/-0.004 and Matthew's correlation coefficient MCC = 0.738), performs significantly better than a number of existing methods using an independent dataset of 1443 protein sequences. AllerHunter is available at (http://tiger.dbs.nus.edu.sg/AllerHunter).

  12. AllerHunter: a SVM-pairwise system for assessment of allergenicity and allergic cross-reactivity in proteins.

    Directory of Open Access Journals (Sweden)

    Hon Cheng Muh

    Full Text Available Allergy is a major health problem in industrialized countries. The number of transgenic food crops is growing rapidly creating the need for allergenicity assessment before they are introduced into human food chain. While existing bioinformatic methods have achieved good accuracies for highly conserved sequences, the discrimination of allergens and non-allergens from allergen-like non-allergen sequences remains difficult. We describe AllerHunter, a web-based computational system for the assessment of potential allergenicity and allergic cross-reactivity in proteins. It combines an iterative pairwise sequence similarity encoding scheme with SVM as the discriminating engine. The pairwise vectorization framework allows the system to model essential features in allergens that are involved in cross-reactivity, but not limited to distinct sets of physicochemical properties. The system was rigorously trained and tested using 1,356 known allergen and 13,449 putative non-allergen sequences. Extensive testing was performed for validation of the prediction models. The system is effective for distinguishing allergens and non-allergens from allergen-like non-allergen sequences. Testing results showed that AllerHunter, with a sensitivity of 83.4% and specificity of 96.4% (accuracy = 95.3%, area under the receiver operating characteristic curve AROC = 0.928+/-0.004 and Matthew's correlation coefficient MCC = 0.738, performs significantly better than a number of existing methods using an independent dataset of 1443 protein sequences. AllerHunter is available at (http://tiger.dbs.nus.edu.sg/AllerHunter.

  13. Inferring the demographic history of African farmers and pygmy hunter-gatherers using a multilocus resequencing data set.

    Directory of Open Access Journals (Sweden)

    Etienne Patin

    2009-04-01

    Full Text Available The transition from hunting and gathering to farming involved a major cultural innovation that has spread rapidly over most of the globe in the last ten millennia. In sub-Saharan Africa, hunter-gatherers have begun to shift toward an agriculture-based lifestyle over the last 5,000 years. Only a few populations still base their mode of subsistence on hunting and gathering. The Pygmies are considered to be the largest group of mobile hunter-gatherers of Africa. They dwell in equatorial rainforests and are characterized by their short mean stature. However, little is known about the chronology of the demographic events-size changes, population splits, and gene flow--ultimately giving rise to contemporary Pygmy (Western and Eastern groups and neighboring agricultural populations. We studied the branching history of Pygmy hunter-gatherers and agricultural populations from Africa and estimated separation times and gene flow between these populations. We resequenced 24 independent noncoding regions across the genome, corresponding to a total of approximately 33 kb per individual, in 236 samples from seven Pygmy and five agricultural populations dispersed over the African continent. We used simulation-based inference to identify the historical model best fitting our data. The model identified included the early divergence of the ancestors of Pygmy hunter-gatherers and farming populations approximately 60,000 years ago, followed by a split of the Pygmies' ancestors into the Western and Eastern Pygmy groups approximately 20,000 years ago. Our findings increase knowledge of the history of the peopling of the African continent in a region lacking archaeological data. An appreciation of the demographic and adaptive history of African populations with different modes of subsistence should improve our understanding of the influence of human lifestyles on genome diversity.

  14. Murine neural stem cells model Hunter disease in vitro: glial cell-mediated neurodegeneration as a possible mechanism involved.

    Science.gov (United States)

    Fusar Poli, E; Zalfa, C; D'Avanzo, F; Tomanin, R; Carlessi, L; Bossi, M; Nodari, L Rota; Binda, E; Marmiroli, P; Scarpa, M; Delia, D; Vescovi, A L; De Filippis, L

    2013-11-07

    Mucopolysaccharidosis type II (MPSII or Hunter Syndrome) is a lysosomal storage disorder caused by the deficit of iduronate 2-sulfatase (IDS) activity and characterized by progressive systemic and neurological impairment. As the early mechanisms leading to neuronal degeneration remain elusive, we chose to examine the properties of neural stem cells (NSCs) isolated from an animal model of the disease in order to evaluate whether their neurogenic potential could be used to recapitulate the early phases of neurogenesis in the brain of Hunter disease patients. Experiments here reported show that NSCs derived from the subventricular zone (SVZ) of early symptomatic IDS-knockout (IDS-ko) mouse retained self-renewal capacity in vitro, but differentiated earlier than wild-type (wt) cells, displaying an evident lysosomal aggregation in oligodendroglial and astroglial cells. Consistently, the SVZ of IDS-ko mice appeared similar to the wt SVZ, whereas the cortex and striatum presented a disorganized neuronal pattern together with a significant increase of glial apoptotic cells, suggesting that glial degeneration likely precedes neuronal demise. Interestingly, a very similar pattern was observed in the brain cortex of a Hunter patient. These observations both in vitro, in our model, and in vivo suggest that IDS deficit seems to affect the late phases of neurogenesis and/or the survival of mature cells rather than NSC self-renewal. In particular, platelet-derived growth factor receptor-α-positive (PDGFR-α+) glial progenitors appeared reduced in both the IDS-ko NSCs and in the IDS-ko mouse and human Hunter brains, compared with the respective healthy controls. Treatment of mutant NSCs with IDS or PDGF throughout differentiation was able to increase the number of PDGFR-α+ cells and to reduce that of apoptotic cells to levels comparable to wt. This evidence supports IDS-ko NSCs as a reliable in vitro model of the disease, and suggests the rescue of PDGFR-α+ glial cells as a

  15. Origin and diet of the prehistoric hunter-gatherers on the mediterranean island of Favignana (Egadi Islands, Sicily.

    Directory of Open Access Journals (Sweden)

    Marcello A Mannino

    Full Text Available Hunter-gatherers living in Europe during the transition from the late Pleistocene to the Holocene intensified food acquisition by broadening the range of resources exploited to include marine taxa. However, little is known on the nature of this dietary change in the Mediterranean Basin. A key area to investigate this issue is the archipelago of the Ègadi Islands, most of which were connected to Sicily until the early Holocene. The site of Grotta d'Oriente, on the present-day island of Favignana, was occupied by hunter-gatherers when Postglacial environmental changes were taking place (14,000-7,500 cal BP. Here we present the results of AMS radiocarbon dating, palaeogenetic and isotopic analyses undertaken on skeletal remains of the humans buried at Grotta d'Oriente. Analyses of the mitochondrial hypervariable first region of individual Oriente B, which belongs to the HV-1 haplogroup, suggest for the first time on genetic grounds that humans living in Sicily during the early Holocene could have originated from groups that migrated from the Italian Peninsula around the Last Glacial Maximum. Carbon and nitrogen isotope analyses show that the Upper Palaeolithic and Mesolithic hunter-gatherers of Favignana consumed almost exclusively protein from terrestrial game and that there was only a slight increase in marine food consumption from the late Pleistocene to the early Holocene. This dietary change was similar in scale to that at sites on mainland Sicily and in the rest of the Mediterranean, suggesting that the hunter-gatherers of Grotta d'Oriente did not modify their subsistence strategies specifically to adapt to the progressive isolation of Favignana. The limited development of technologies for intensively exploiting marine resources was probably a consequence both of Mediterranean oligotrophy and of the small effective population size of these increasingly isolated human groups, which made innovation less likely and prevented transmission of

  16. Prokaryotic expression, purification and identification of NY-ESO-1/GST fusion protein in E.coli%NY-ESO-1/GST融合蛋白在大肠杆菌的表达、纯化及鉴定

    Institute of Scientific and Technical Information of China (English)

    汤蕾; 宋朝君; 孙元杰; 李娜; 魏玉英; 孙奕; 杨琨

    2012-01-01

    AIM: To construct an expression plasmid for NY-ESO-1 gene and identify the expression of recombinant protein NY-ESO-1/GST in E. coli. METHODS: NY-ESO-1 segment was amplified from the testis cDNA library by RT-PCR and cloned into the prokaryotic expression vector pGEX4T-l downstream tagged by GST to construct the expression plasmid pGEX4Tl-NY-ESO-l. The recombinant vector was transformed to BL21 ( DE3) and NY-ESO-1/ GST fusion protein was induced expression by IPTG. The protein was purified by urea elution and identified by SDS-PAGE and Western blotting. RESULTS: The NY-ESO-1 segment was successfully amplified and its sequence was identical with that published in GenBank. The BL21 (DE3) pLysS containing the pGEX-Tl-NY-ESO-1 expressed a M, 44 000 fusion protein under the induction of IPTG. The purity of the protein was 90%. Western blotting proved that NY-ESO-1/GST had a specific reaction with anti-GST mAb. CONCLUSION; The prokaryotic expression vector of NY-ESO-1 has been constructed and the fusion protein NY-ESO-1/GST of high purity is successfully expressed.%目的:构建肿瘤-睾丸抗原NY-ESO-1与GST融合基因的原核表达载体,在大肠杆菌中表达并对融合蛋白NY-ESO-1/GST进行纯化和初步鉴定.方法:设计针对NY-ESO-1的特异性引物,采用聚合酶链反应(PCR)从睾丸组织的cDNA文库扩增NY-ESO-1基因片段,经上下游引物所引入的EcoR I和Xho I双酶切后克隆人原核表达载体pGEX-4T1中GST标签的下游,构建重组表达载体pGEX-4T1-NY-ESO-1,并将该载体转化大肠杆菌BL21( DE3) pLysS中,IPTG诱导表达NYESO-1/GST融合蛋白,经不同浓度尿素洗脱纯化后,表达产物通过SDS-PAGE和Western blot法进行鉴定.结果:重组质粒经限制性内切酶EcoR I和Xho I双酶切鉴定和IPTG诱导表达NY-ESO-1/GST的SDS-PAGE分析表明,表达产物的相对分子质量(Mr)为44000,与理论值相符,并主要以包涵体形式存在,灰度扫描分析显示融合蛋白表

  17. Planet Hunters: the first two planet candidates identified by the public using the Kepler public archive data

    Science.gov (United States)

    Fischer, Debra A.; Schwamb, Megan E.; Schawinski, Kevin; Lintott, Chris; Brewer, John; Giguere, Matt; Lynn, Stuart; Parrish, Michael; Sartori, Thibault; Simpson, Robert; Smith, Arfon; Spronck, Julien; Batalha, Natalie; Rowe, Jason; Jenkins, Jon; Bryson, Steve; Prsa, Andrej; Tenenbaum, Peter; Crepp, Justin; Morton, Tim; Howard, Andrew; Beleu, Michele; Kaplan, Zachary; Vannispen, Nick; Sharzer, Charlie; Defouw, Justin; Hajduk, Agnieszka; Neal, Joe P.; Nemec, Adam; Schuepbach, Nadine; Zimmermann, Valerij

    2012-02-01

    Planet Hunters is a new citizen science project designed to engage the public in an exoplanet search using NASA Kepler public release data. In the first month after launch, users identified two new planet candidates which survived our checks for false positives. The follow-up effort included analysis of Keck HIRES spectra of the host stars, analysis of pixel centroid offsets in the Kepler data and adaptive optics imaging at Keck using NIRC2. Spectral synthesis modelling coupled with stellar evolutionary models yields a stellar density distribution, which is used to model the transit orbit. The orbital periods of the planet candidates are 9.8844 ± 0.0087 d (KIC 10905746) and 49.7696 ± 0.000 39 d (KIC 6185331), and the modelled planet radii are 2.65 and 8.05 R⊕. The involvement of citizen scientists as part of Planet Hunters is therefore shown to be a valuable and reliable tool in exoplanet detection. This publication has been made possible by the participation of more than 40 000 volunteers in the Planet Hunters project. Their contributions are individually acknowledged at .

  18. The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists.

    Science.gov (United States)

    Patin, Etienne; Siddle, Katherine J; Laval, Guillaume; Quach, Hélène; Harmant, Christine; Becker, Noémie; Froment, Alain; Régnault, Béatrice; Lemée, Laure; Gravel, Simon; Hombert, Jean-Marie; Van der Veen, Lolke; Dominy, Nathaniel J; Perry, George H; Barreiro, Luis B; Verdu, Paul; Heyer, Evelyne; Quintana-Murci, Lluís

    2014-01-01

    The emergence of agriculture in West-Central Africa approximately 5,000 years ago, profoundly modified the cultural landscape and mode of subsistence of most sub-Saharan populations. How this major innovation has had an impact on the genetic history of rainforest hunter-gatherers-historically referred to as 'pygmies'-and agriculturalists, however, remains poorly understood. Here we report genome-wide SNP data from these populations located west-to-east of the equatorial rainforest. We find that hunter-gathering populations present up to 50% of farmer genomic ancestry, and that substantial admixture began only within the last 1,000 years. Furthermore, we show that the historical population sizes characterizing these communities already differed before the introduction of agriculture. Our results suggest that the first socio-economic interactions between rainforest hunter-gatherers and farmers introduced by the spread of farming were not accompanied by immediate, extensive genetic exchanges and occurred on a backdrop of two groups already differentiated by their specialization in two ecotopes with differing carrying capacities.

  19. Assessment of risk to aquatic biota from elevated salinity -- a case study from the Hunter River, Australia.

    Science.gov (United States)

    Muschal, Monika

    2006-05-01

    An ecological risk assessment was performed on salinity levels of the Hunter River and its tributaries to respond to concerns that high salinity may be damaging aquatic ecosystems. Probabilistic techniques were used to assess likelihood and consequence, and hence the risk to aquatic biota from salinity. Continuous electrical conductivity distributions were used to describe the likelihood that high salinity would occur (exposure dataset) and toxicity values were compiled from the limited literature sources available to describe the consequence of high salinity (effects dataset). The assessment was preliminary in the sense that it modelled risk on the basis of existing data and did not undertake site-specific toxicity testing. Some sections of the Hunter River catchment have geologies that are saline because of their marine origins. Catchment development has increased the liberation rates of salts into surface-waters. Such modifying activities include coal-mining, power generation and land clearing. The aquatic biota of tributaries had a greater risk of impairment from high salinity than that of the Hunter River. High salinities in the tributaries were attributed to the combined factors of naturally saline geologies, increased liberation of salts due to modification of the landscape, and reduced dilution by flushing flows. A salinity guideline trigger value of 1100 mg L(-1) was recommended.

  20. Detection of a new mutation (T1140C) in a patient with Hunter syndrome from Guangdong,China

    Institute of Scientific and Technical Information of China (English)

    GUO Yibin; DU Chuanshu; WANG Jingjing

    2007-01-01

    This study identified mutations of the idumate-2-suffatase (IDS) gene in a patient with Hunter syndrome,and established a basis for the diagnosis of the prenatal gene of Hunter syndrome.Urine glyeosaminoglycan (GAG) assay was used to make the preliminary diagnosis of mucopolysaccharidosis type H.Polymerase chain reaction (PCR) from dried blood spots and DNA sequencing were applied to analyze hotspot mutations in exons 9,3 and 8 of the IDS gene in the proband and his parents.A new missense mutation (T1140C) in exon 8 of the IDS gene was found by using DNA sequencing.This mutation caused a substitution of codon 339 from CTA (leucine) to CCA (praline).The patient is a hemizygote,and his mother is a heterozygote.The new missense mutation results in a change in the primary and tertiary structure of the IDS protein.It is possible that this mutation severely impairs enzymatic activity and is the underlying basis for the pathology seen in this patient with Hunter syndrome.

  1. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Science.gov (United States)

    2010-07-01

    ... of Porter Avenue, Buffalo, N.Y. 110.84 Section 110.84 Navigation and Navigable Waters COAST GUARD... Channel opposite foot of Porter Avenue, Buffalo, N.Y. An area extending northwesterly between Black Rock Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning at...

  2. 78 FR 62293 - Safety Zone, Oyster Festival 30th Anniversary Fireworks Display, Oyster Bay; Oyster Bay, NY

    Science.gov (United States)

    2013-10-15

    ... CFR Part 165 RIN 1625-AA00 Safety Zone, Oyster Festival 30th Anniversary Fireworks Display, Oyster Bay; Oyster Bay, NY AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on the navigable waters of Oyster Bay near Oyster Bay, NY for the...

  3. 78 FR 38310 - Kiwi Energy NY LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

    Science.gov (United States)

    2013-06-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Kiwi Energy NY LLC; Supplemental Notice That Initial Market-Based Rate... notice in the above-referenced proceeding, of Kiwi Energy NY LLC's application for market-based...

  4. Transfection of NY-ESO-1 specific TCR improves the specific cytotoxicity of human PBMC to NY-ESO-1 positive tumor cells%转染NY-ESO-1特异性TCR增强人PBMC对NY-ESO-1阳性肿瘤细胞的特异性细胞毒性

    Institute of Scientific and Technical Information of China (English)

    郭佳; 田洲; 顾娜; 徐珩; 闾军

    2013-01-01

    Objective To study whether NY-ESO-1-specific TCR gene transduced into human PBMC (Peripheral Blood Mononuclear Cell, PBMC) can improve its abilities of specifically recognizing and killing tumor cells. Methods pCDNA3. 1-ESO-TCR plasmid was electroporately transferred into PBMC separated from healthy people in vitro and confirmed by RT-PCR. The phenotype analysis after eletroporation was measured by flow cytometry method. The NY-ESO-1 specific peptide (pl57-165) was added into the culture of electroporated PBMC, the IFN-γ level secreted by electroporated PBMC was detected by ELISPOT assay. The specific cytotoxicity in vitro was detected by real time cell analysis (ACEA biosciences). Results The NY-ESO-1-specific TCR fragments in electroporated PBMC were detected by RT-PCR. The specific expression of NY-ESO-TCR in transferred PBMC was significantly higher than that in PBMC transfered with empty vector (P < 0. 05). The positive dots of IFN-γ secretion in transferred PBMC stimulated by peptide pl57-165 was significantly more than that in PBMC transfered with empty vector (P <0. 05); The specific cytotoxicity of transferred PBMC was obviously enhanced than PBMC transduced with empty vector. Conclusions The specific cytotoxicity of PBMC against NY-ESO-1 positive HepG2 cells is elevated by transduced PBMC with NY-ESO-1 specific TCR, which may stimulate more researches about adoptive immunotherapy of hepatocellular carcinoma.%目的 探讨体外转导NY-ESO-1特异性T细胞受体至人外周血淋巴细胞中,是否可增强转导后细胞体外特异性识别并杀伤肿瘤细胞的能力.方法 将NY-ESO-1特异性TCR质粒(pCDNA3.1-ESO-TCR)体外电转入新分离的正常人PBMC中,RT-PCR法鉴定转导是否成功;采用流式细胞仪分析转导后PBMC表型;用特异性NY-ESO-1b抗原肽(p157-165)刺激转导PBMC后,用ELISPOT法检测PBMC分泌IFN-γ的能力,用实时无标记动态细胞分析仪检测PBMC特异性细胞毒性作用.结果 电转后PBMC

  5. College Drinking

    Science.gov (United States)

    ... Harmful and Underage College Drinking Drinking affects college students, their families, and college communities at large. Researchers estimate that ... heavy drinking and alcohol-related consequences because of student expectations and social pressures at the start of the academic year. How ...

  6. College Readiness

    Science.gov (United States)

    Chapa, Marisa; Galvan-De Leon, Vanessa; Solis, Judith; Mundy, Marie-Anne

    2014-01-01

    During the 79th Texas Legislature, the bill "Advancement of College Readiness in Curriculum" was passed (THECB). As a response to this, high schools and colleges have combined forming an early college high school. The result of this union was a program that condensed the time it took to complete both the high school diploma and up to two…

  7. Voice pitch alters mate-choice-relevant perception in hunter-gatherers.

    Science.gov (United States)

    Apicella, Coren L; Feinberg, David R

    2009-03-22

    In humans, voice pitch is thought to be a cue of underlying quality and an important criterion for mate choice, but data from non-Western cultures have not been provided. Here we test attributions to and preferences for voices with raised and lowered pitch in hunter-gatherers. Using a forced-choice playback experiment, we found that both men and women viewed lower pitched voices in the opposite sex as being better at acquiring resources (e.g. hunting and gathering). While men preferred higher pitched women's voices as marriage partners, women showed no overall preference for voice pitch in men. However, women who were currently breastfeeding had stronger preferences for higher pitched male voices whereas women not currently breastfeeding preferred lower pitched voices. As testosterone is considered a costly signal associated with dominance, heritable immunity to infection and low paternal investment, women's preferences potentially reflect a trade-off between securing good genes and paternal investment. Men's preferences for higher pitched female voices are probably due to an evolved preference for markers of fecundity, reflected in voice pitch.

  8. Planet Hunters. VIII. Characterization of 41 Long-Period Exoplanet Candidates from Kepler Archival Data

    CERN Document Server

    Wang, Ji; Barclay, Thomas; Picard, Alyssa; Ma, Bo; Bowler, Brendan P; Schmitt, Joseph R; Boyajian, Tabetha S; Jek, Kian J; LaCourse, Daryll; Baranec, Christoph; Riddle, Reed; Law, Nicholas M; Lintott, Chris; Schawinski, Kevin; Simister, Dean Joseph; Gregoire, Boscher; Babin, Sean P; Poile, Trevor; Jacobs, Thomas Lee; Jebson, Tony; Omohundro, Mark R; Schwengeler, Hans Martin; Sejpka, Johann; Terentev, Ivan A; Gagliano, Robert; Paakkonen, Jari-Pekka; Berge, Hans Kristian Otnes; Winarski, Troy; Green, Gerald R; Schmitt, Allan R

    2015-01-01

    The census of exoplanets is incomplete for orbital distances larger than 1 AU. Here, we present 41 long-period planet candidates in 38 systems identified by Planet Hunters based on Kepler archival data (Q0-Q17). Among them, 17 exhibit only one transit, 14 have two visible transits and 10 have more than three visible transits. For planet candidates with only one visible transit, we estimate their orbital periods based on transit duration and host star properties. The majority of the planet candidates in this work (75%) have orbital periods that correspond to distances of 1-3 AU from their host stars. We conduct follow-up imaging and spectroscopic observations to validate and characterize planet host stars. In total, we obtain adaptive optics images for 33 stars to search for possible blending sources. Six stars have stellar companions within 4". We obtain high-resolution spectra for 6 stars to determine their physical properties. Stellar properties for other stars are obtained from the NASA Exoplanet Archive a...

  9. Securing a Future: Cree Hunters' Resistance and Flexibility to Environmental Changes, Wemindji, James Bay

    Directory of Open Access Journals (Sweden)

    Jesse S. Sayles

    2010-12-01

    Full Text Available Accounts of the adaptive responses of northern aboriginal peoples include examples of purposive modification and management of ecologically favorable areas to increase resource productivity. Practices include clearing of trees, burning of berry patches and construction of fish weirs. This paper examines the adaptive capacity of the northern aboriginal community of Wemindji, east coast James Bay, in relation to long term landscape changes induced by coastal uplift processes. Associated changes are noticeable within a human lifetime and include the infilling of bays, the merger of islands with the mainland, as well as shifts in vegetative and wildlife communities. In response, generations of Cree hunters have actively modified the landscape using a variety of practices that include the construction of mud dykes and the cutting of tuuhiikaan, which are corridors in the coastal forest, to retain and enhance desirable conditions for goose hunting. We provide an account of the history, construction, and design of these features as well as the motivations and social learning that inform them. We reveal a complex and underappreciated dynamic between human resistance and adaptation to environmental change. While landscape modifications are motivated by a desire to increase resource productivity and predictability, they also reflect an intergenerational commitment to the maintenance of established hunting places as important connections with the past. Our findings support a revised perspective on aboriginal human agency in northern landscape modification and an enhanced role for aboriginal communities in adaptive planning for environmental change.

  10. Skills, division of labour and economies of scale among Amazonian hunters and South Indian honey collectors.

    Science.gov (United States)

    Hooper, Paul L; Demps, Kathryn; Gurven, Michael; Gerkey, Drew; Kaplan, Hillard S

    2015-12-01

    In foraging and other productive activities, individuals make choices regarding whether and with whom to cooperate, and in what capacities. The size and composition of cooperative groups can be understood as a self-organized outcome of these choices, which are made under local ecological and social constraints. This article describes a theoretical framework for explaining the size and composition of foraging groups based on three principles: (i) the sexual division of labour; (ii) the intergenerational division of labour; and (iii) economies of scale in production. We test predictions from the theory with data from two field contexts: Tsimane' game hunters of lowland Bolivia, and Jenu Kuruba honey collectors of South India. In each case, we estimate the impacts of group size and individual group members' effort on group success. We characterize differences in the skill requirements of different foraging activities and show that individuals participate more frequently in activities in which they are more efficient. We evaluate returns to scale across different resource types and observe higher returns at larger group sizes in foraging activities (such as hunting large game) that benefit from coordinated and complementary roles. These results inform us that the foraging group size and composition are guided by the motivated choice of individuals on the basis of relative efficiency, benefits of cooperation, opportunity costs and other social considerations.

  11. Planet Hunters: A Transiting Circumbinary Planet in a Quadruple Star System

    CERN Document Server

    Schwamb, Megan E; Carter, Joshua A; Welsh, William F; Fischer, Debra A; Torres, Guillermo; Howard, Andrew W; Crepp, Justin R; Keel, William C; Lintott, Chris J; Kaib, Nathan A; Terrell, Dirk; Gagliano, Robert; Jek, Kian J; Parrish, Michael; Smith, Arfon M; Lynn, Stuart; Simpson, Robert J; Giguere, Matthew J; Schawinski, Kevin

    2012-01-01

    We report the discovery and confirmation of a transiting circumbinary planet (PH1) around KIC 4862625, an eclipsing binary in the Kepler field. The planet was discovered by volunteers searching the first six Quarters of publicly available Kepler data as part of the Planet Hunters citizen science project. Transits of the planet across the larger and brighter of the eclipsing stars are detectable by visual inspection every ~137 days, with seven transits identified in Quarters 1-11. The physical and orbital parameters of both the host stars and planet were obtained via a photometric-dynamical model, simultaneously fitting both the measured radial velocities and the Kepler light curve of KIC 4862625.The 6.18 $\\pm$ 0.17 Earth radii planet orbits outside the 20-day orbit of an eclipsing binary consisting of an F dwarf (1.734 +/- 0.044 Solar radii, 1.528 +/- 0.087 Solar masses) and M dwarf (0.378 +/0 0.023 Solar radii, 0.408 +/- 0.024 solar masses). For the planet, we find an upper mass limit of 169 Earth masses(0.5...

  12. Competition for Cooperation: variability, benefits and heritability of relational wealth in hunter-gatherers.

    Science.gov (United States)

    Chaudhary, Nikhil; Salali, Gul Deniz; Thompson, James; Rey, Aude; Gerbault, Pascale; Stevenson, Edward Geoffrey Jedediah; Dyble, Mark; E Page, Abigail; Smith, Daniel; Mace, Ruth; Vinicius, Lucio; Migliano, Andrea Bamberg

    2016-07-12

    Many defining human characteristics including theory of mind, culture and language relate to our sociality, and facilitate the formation and maintenance of cooperative relationships. Therefore, deciphering the context in which our sociality evolved is invaluable in understanding what makes us unique as a species. Much work has emphasised group-level competition, such as warfare, in moulding human cooperation and sociality. However, competition and cooperation also occur within groups; and inter-individual differences in sociality have reported fitness implications in numerous non-human taxa. Here we investigate whether differential access to cooperation (relational wealth) is likely to lead to variation in fitness at the individual level among BaYaka hunter-gatherers. Using economic gift games we find that relational wealth: a) displays individual-level variation; b) provides advantages in buffering food risk, and is positively associated with body mass index (BMI) and female fertility; c) is partially heritable. These results highlight that individual-level processes may have been fundamental in the extension of human cooperation beyond small units of related individuals, and in shaping our sociality. Additionally, the findings offer insight in to trends related to human sociality found from research in other fields such as psychology and epidemiology.

  13. Jaguar conservation in southern Belize: Conflicts, perceptions, and prospects among mayan hunters

    Directory of Open Access Journals (Sweden)

    Michael K Steinberg

    2016-01-01

    Full Text Available Belize has emerged as an international leader in jaguar conservation through the creation of numerous protected areas that contain prime cat habitat and by strengthening conservation laws. For example, in 1984, Belize created the Cockscomb Basin Jaguar Preserve, the first special jaguar protection area in the Americas. In 1995, the government expanded Cockscomb by creating the adjacent Chiquibul National Park. In 2010, the government continued this commitment to jaguar conservation by creating the Labouring Creek Jaguar Corridor Wildlife Sanctuary in central Belize. As a result of these protected areas, Belize has been rightfully lauded as a leader in nature-based tourism and protected areas creation in Central America. However, outside national parks and communities that directly benefit from ecotourism, it is less clear how supportive rural residents are of cat conservation. It is also not clear if jaguars persist outside protected areas in locations such as southern Belize, where the environment has been significantly altered by human activities. Through interviews with Mayan hunters, this paper investigates the attitudes towards jaguars, human-jaguar conflicts, and potential community-based jaguar conservation in two Mayan villages in the Toledo District in southern Belize. Also, using indirect methods, the paper documents the presence/absence and other temporal/spatial aspects of jaguars in a heavily altered landscape in southern Belize.

  14. Schooling, Local Knowledge and Working Memory: A Study among Three Contemporary Hunter-Gatherer Societies.

    Science.gov (United States)

    Reyes-García, Victoria; Pyhälä, Aili; Díaz-Reviriego, Isabel; Duda, Romain; Fernández-Llamazares, Álvaro; Gallois, Sandrine; Guèze, Maximilien; Napitupulu, Lucentezza

    2016-01-01

    Researchers have analysed whether school and local knowledge complement or substitute each other, but have paid less attention to whether those two learning models use different cognitive strategies. In this study, we use data collected among three contemporary hunter-gatherer societies with relatively low levels of exposure to schooling yet with high levels of local ecological knowledge to test the association between i) schooling and ii) local ecological knowledge and verbal working memory. Participants include 94 people (24 Baka, 25 Punan, and 45 Tsimane') from whom we collected information on 1) schooling and school related skills (i.e., literacy and numeracy), 2) local knowledge and skills related to hunting and medicinal plants, and 3) working memory. To assess working memory, we applied a multi-trial free recall using words relevant to each cultural setting. People with and without schooling have similar levels of accurate and inaccurate recall, although they differ in their strategies to organize recall: people with schooling have higher results for serial clustering, suggesting better learning with repetition, whereas people without schooling have higher results for semantic clustering, suggesting they organize recall around semantically meaningful categories. Individual levels of local ecological knowledge are not related to accurate recall or organization recall, arguably due to overall high levels of local ecological knowledge. While schooling seems to favour some organization strategies this might come at the expense of some other organization strategies.

  15. Schooling, Local Knowledge and Working Memory: A Study among Three Contemporary Hunter-Gatherer Societies.

    Directory of Open Access Journals (Sweden)

    Victoria Reyes-García

    Full Text Available Researchers have analysed whether school and local knowledge complement or substitute each other, but have paid less attention to whether those two learning models use different cognitive strategies. In this study, we use data collected among three contemporary hunter-gatherer societies with relatively low levels of exposure to schooling yet with high levels of local ecological knowledge to test the association between i schooling and ii local ecological knowledge and verbal working memory. Participants include 94 people (24 Baka, 25 Punan, and 45 Tsimane' from whom we collected information on 1 schooling and school related skills (i.e., literacy and numeracy, 2 local knowledge and skills related to hunting and medicinal plants, and 3 working memory. To assess working memory, we applied a multi-trial free recall using words relevant to each cultural setting. People with and without schooling have similar levels of accurate and inaccurate recall, although they differ in their strategies to organize recall: people with schooling have higher results for serial clustering, suggesting better learning with repetition, whereas people without schooling have higher results for semantic clustering, suggesting they organize recall around semantically meaningful categories. Individual levels of local ecological knowledge are not related to accurate recall or organization recall, arguably due to overall high levels of local ecological knowledge. While schooling seems to favour some organization strategies this might come at the expense of some other organization strategies.

  16. The neutrino hunters the chase for the ghost particle and the secrets of the universe

    CERN Document Server

    Jayawardhana, Ray

    2014-01-01

    In Neutrino Hunters, the renowned astrophysicist and award-winning writer Ray Jayawardhana takes us on a thrilling journey into the shadowy world of neutrinos and the colorful lives of those who seek them. Demystifying particle science along the way, Jayawardhana tells a detective story with cosmic implications—interweaving tales of the sharp-witted theorist Wolfgang Pauli; the troubled genius Ettore Majorana; the harbinger of the atomic age Enrico Fermi; the notorious Cold War defector Bruno Pontecorvo; and the dynamic dream team of Marie and Pierre Curie. Then there are the scientists of today who have caught the neutrino bug, and whose experimental investigations stretch from a working nickel mine in Ontario to a long tunnel through a mountain in central Italy, from a nuclear waste site in New Mexico to a bay on the South China Sea, and from Olympic-size pools deep underground to a gigantic cube of Antarctic ice—called, naturally, IceCube. As Jayawardhana recounts a captivating saga of scientific disc...

  17. The Implications of Victimhood Identity: The Case of ‘Persecution’ of Swedish Hunters

    Directory of Open Access Journals (Sweden)

    Erica von Essen

    2017-06-01

    Full Text Available This ethnographically based study examines Swedish hunters’ claims to victimhood through appeal to the term ‘persecution’. Perceiving disenfranchisement, injustice and discrimination on the basis of wolf conservation policy, we present hunters’ self-styled predicament as victimhood-claimants of persecution at the hands of a state that has been co-opted by a conservationist, pro-wolf agenda that systematically disenfranchises rural and hunting interests and lifestyles. Through the phenomenological accounts of hunter respondents, our paper takes seriously the hunters’ perception of persecution and, likewise, considers the opposite case made by conservationists: that wolves have been, and continue to be, the real victims of persecution in the conflict. Nonetheless, we show that the persecution language as it is applied from opposing parties in the conflict is problematic inasmuch as it is focused around creating a moral panic and confusion among the Swedish public who are ultimately responsible, as a democratic body-politic, for assessing the legitimacy of claims to moral wrong-doing and legal redress for the wronged. Our case study joins scholarship that explores the pathologies of claims to victimization

  18. Robert Plant (1818–1858: A Victorian plant hunter in Natal, Zululand, Mauritius and the Seychelles

    Directory of Open Access Journals (Sweden)

    Donal P. McCracken

    2011-03-01

    Full Text Available In the 1850s Robert William Plant collected plants and other natural specimens in what is now KwaZulu-Natal. This one-time Englishman compiled a dictionary for gardeners before emigrating to Natal in 1850. There he worked as the agent for Samuel Stevens, the London dealer in ‘curiosities of natural history’. Though Plant collected mainly plants, he also sent consignments of beetles, butterflies, bird skins and shells back to Britain. He published the first scientific paper on Zululand and was requested by the Royal Botanic Gardens at Kew to write the first Flora natalensis. It was while collecting for this never-to-be-completed treatise that Plant contracted malaria in Maputaland. He died in St Lucia in 1858 and in doing so became South Africa’s martyr to botany. What emerges from this study is a picture of the difficulties faced by plant hunters in mid-19th-century South Africa, the sort of plants they collected and the necessity for them sometimes to diversify into other natural history products to survive.

  19. Hunter-gatherer mobility and embedded raw-material procurement strategies in the mediterranean upper paleolithic.

    Science.gov (United States)

    Tomasso, Antonin; Porraz, Guillaume

    2016-05-06

    Since the early 1980s, the sourcing of lithic raw materials has become central to studies of the territorial range and mobility strategies of Pleistocene foraging societies. Results have been fruitful but somehow repetitive. We will discuss the embedded procurement strategy, which presumes that raw material acquisition was part of other subsistence activities rather than an autonomous technological task. We argue that this theoretical assumption, when taken as dogma, restricts the role of technology in human history and also underestimates the way some lithic resources may have affected the organization of past hunter-gatherers. We base our discussion on the Upper Paleolithic (UP) from the Liguro-Provençal arc, with examples from the Proto-Aurignacian and the Epigravettian. Our regional record shows that in this context the movement of rocks over distances greater than 100 km was the norm rather than the exception. We argue that these long-distance procurements mirror technical needs that were oriented toward the selection of high-quality flints. We support the hypothesis that indirect procurement was an important component of regional socio-economic networks.

  20. Atypical clinical presentation of mucopolysaccharidosis type II (Hunter syndrome: a case report

    Directory of Open Access Journals (Sweden)

    Sharma Subodh

    2010-05-01

    Full Text Available Abstract Introduction We present a very rare case of mucopolysaccharidosis with atypical presentation such as mild mental retardation, an acrocephalic head and no corneal clouding. The purpose of presenting this case is to highlight the distinctive manifestation of mucopolysaccharidosis type II (Hunter syndrome. Case presentation A 10-year-old East Asian boy presented with abdominal distension of five years' duration and complained of shortness of breath on and off for the same period. On examination his head was large and his head circumference was 54.5 cm. His neck was short, he had coarse facial features, a depressed nasal bridge and small stubby fingers with flexion of distal interphalangeal joints, and a low arched palate was observed. There was mild mental retardation. Conclusion Based on clinical findings and radiological features it is possible to diagnose a case of mucopolysaccharidosis. Careful and systemic approach is needed to accurately diagnose the exact type as enzymatic studies are not available in most centers.

  1. The Hunters Point cogeneration project: Environmental justice in power plant siting

    Energy Technology Data Exchange (ETDEWEB)

    Kosloff, L.H. [Trexler and Associates, Inc., Portland, OR (United States); Varanini, E.E. III [Marron, Reid and Sheehy, Sacramento, CA (United States)

    1997-12-31

    The recent Hunters Point, San Francisco power plant siting process in California represents the first time that environmental justice has arisen as a major power plant siting issue. Intervenors argued that the siting process was racially and economically biased and were supported by leading environmental justice activists at the Golden Gate Law School`s Environmental Justice Clinic, a leading thinker in this field. The applicant argued that environmental justice charges cannot realistically be made against a modern natural-gas energy facility with state-of-the-art environmental controls. The applicant also argued that environmental justice concerns were fully addressed through the extensive environmental and socioeconomic review carried out by California Energy Commission staff. After extensive testimony and cross-examination, the Commission agreed with the applicant. This case has important lessons for companies that could be charged with environmental justice violations and environmental justice activists who must decide where to most effectively target their efforts. This paper reviews the proceeding and its lessons and makes recommendations regarding future applicability of environmental justice issues to the power generation sector. The authors represented the applicant in the facility siting proceeding.

  2. Trace elements associated with atmospheric particulate matter in the Upper Hunter Valley, NSW, Australia

    Energy Technology Data Exchange (ETDEWEB)

    Farhana, Biswas Karabi [Bangladesh Institute of Research and Rehabilitation in Diabetes, Endcrine and Metabolic Disorders (BIRDEM), Research Division, Dhaka (Bangladesh); Bridgman, Howard [University of Newcastle, Dept. of Geography and Environmental Science (Australia); McOrist, Gordon [Australian Nuclear Science and Technology Organization (ANSTO), Environment Division, Menai (Australia)

    2002-05-01

    Airbone particulate matter, both total suspended particulate (TSP) and PM{sub 10}, and soil samples from four sampling sites were collected in the Upper Hunter Valley in NSW, Australia in early 1999. This study aimed to measure relative amounts of particulates during this period, and identify associated trace elements and their potential sources. Particulates were analyzed for trace elements using Neutron Activation Analysis technique. Total concentrations ({mu}g m{sup -3}) of TSP and PM{sub 10} varied within 7-135 and 4-19, respectively, among sampling sites. Mean concentrations (ng m{sup -3}) of iron, barium, zinc, lanthanum, bromine, chromium, rubidium, neodymium, cobalt, hafnium, cerium, thorium, uranium, scandium and cesium varied within 2042-2867, 529-1500, 28-40, 5.45-11.44, 5.3-20.6, 10.4-12.7, 4.14-11.56, 5.4-8.1, 1.16-1.98, 1.76-2.17, 0.71-3.9, 0.21-0.50, 0.29-0.84, 0.28-1.23, and 0.18-0.30, respectively. Significant correlation between sites for many elements suggested some common source(s) of some elements. The enrichment levels of the trace elements identified some crustal materials as a predominant source of particulate matter. (author)

  3. Hunter-gatherer inter-band interaction rates: implications for cumulative culture.

    Directory of Open Access Journals (Sweden)

    Kim R Hill

    Full Text Available Our species exhibits spectacular success due to cumulative culture. While cognitive evolution of social learning mechanisms may be partially responsible for adaptive human culture, features of early human social structure may also play a role by increasing the number potential models from which to learn innovations. We present interview data on interactions between same-sex adult dyads of Ache and Hadza hunter-gatherers living in multiple distinct residential bands (20 Ache bands; 42 Hadza bands; 1201 dyads throughout a tribal home range. Results show high probabilities (5%-29% per year of cultural and cooperative interactions between randomly chosen adults. Multiple regression suggests that ritual relationships increase interaction rates more than kinship, and that affinal kin interact more often than dyads with no relationship. These may be important features of human sociality. Finally, yearly interaction rates along with survival data allow us to estimate expected lifetime partners for a variety of social activities, and compare those to chimpanzees. Hadza and Ache men are estimated to observe over 300 men making tools in a lifetime, whereas male chimpanzees interact with only about 20 other males in a lifetime. High intergroup interaction rates in ancestral humans may have promoted the evolution of cumulative culture.

  4. Potential Roles of Essential Oil and Extracts of Piper chaba Hunter to Inhibit Listeria monocytogenes

    Directory of Open Access Journals (Sweden)

    Atiqur Rahman

    2011-01-01

    Full Text Available The in vitro anti-listerial potential of essential oil and various organic extracts of Piper chaba Hunter (Piperaceae were evaluated. The chemical composition of the essential oil was analyzed by the GC-MS. Fifty four compounds representing 95.4% of the total oil w ere identified, of which α-humulene (16.4%, caryophyllene oxide (12.2%, veridiflorol (8.1%, globulol (7.4%, β-selinene (7.1%, spathulenol (6.2%, trans-nerolidol (5.1%, linalool (4.5%, 3-pentanol (3.5%, tricyclene (2.2% and p-cymene (1.6% were the major compounds. The oil and organic extracts revealed a great potential anti-listerial effect against all five strains of Listeriamonocytogenes ATCC 19111, 19116, 19118, 19166 and 15313. Also the essential oil had a strong inhibitory effect on the viable cell count of the tested Listeria spp. Our findings demonstrate that the essential oil and extracts derived from the leaf of P. chaba might be a potential source of natural preservatives used in food industries.

  5. Hunter-gatherer inter-band interaction rates: implications for cumulative culture.

    Science.gov (United States)

    Hill, Kim R; Wood, Brian M; Baggio, Jacopo; Hurtado, A Magdalena; Boyd, Robert T

    2014-01-01

    Our species exhibits spectacular success due to cumulative culture. While cognitive evolution of social learning mechanisms may be partially responsible for adaptive human culture, features of early human social structure may also play a role by increasing the number potential models from which to learn innovations. We present interview data on interactions between same-sex adult dyads of Ache and Hadza hunter-gatherers living in multiple distinct residential bands (20 Ache bands; 42 Hadza bands; 1201 dyads) throughout a tribal home range. Results show high probabilities (5%-29% per year) of cultural and cooperative interactions between randomly chosen adults. Multiple regression suggests that ritual relationships increase interaction rates more than kinship, and that affinal kin interact more often than dyads with no relationship. These may be important features of human sociality. Finally, yearly interaction rates along with survival data allow us to estimate expected lifetime partners for a variety of social activities, and compare those to chimpanzees. Hadza and Ache men are estimated to observe over 300 men making tools in a lifetime, whereas male chimpanzees interact with only about 20 other males in a lifetime. High intergroup interaction rates in ancestral humans may have promoted the evolution of cumulative culture.

  6. Tumour Angiogenesis: A Growth Area—From John Hunter to Judah Folkman and Beyond

    Directory of Open Access Journals (Sweden)

    J. A. Stephenson

    2013-01-01

    Full Text Available Angiogenesis is the growth of new blood vessels in the body. Abnormal angiogenesis is recognised as a “common denominator” in many disease processes, and the development of angiogenesis inhibitors holds great hope in the ongoing battle against cancer. The field of angiogenesis has roots in the Hunterian era of the late eighteenth century but did not begin to blossom until the early 1970s when the then controversial findings and conclusions of Judah Folkman, the “father of angiogenesis,” were first published. There were only 65 publications with angiogenesis in the title in the 10 years after Folkman first proposed the idea of tumour angiogenesis, compared to over 9,000 publications from the year 2000 to 2010. In this review we will explore the voyage of discovery from the first observations of John Hunter in the eighteenth century, via the struggle faced by Folkman to prove the importance of angiogenesis, and finally how his determination has led to modern angiogenesis inhibitors being used in everyday clinical practice.

  7. Research-based learning. Koncept for studenterdeltagelse i forsknings- og udviklingsaktiviteter ved University College Lillebælt

    DEFF Research Database (Denmark)

    Hansen, Birgit Heimann

    2015-01-01

    Studenterdeltagelse i forsknings- og udviklingsaktiviteter er en forholdsvis ny og endnu ikke organiseret studieaktivitet, og derfor undersøges med projektet RESEARCH-BASED LEARNING: KONCEPT FOR STUDENTERDELTAGELSE I FORSKNINGS- OG UDVIKLINGSAKTIVITETER VED UNIVERSITY COLLEGE LILLEBÆLT, hvordan...... forslag til et koncept for studenterdeltagelse i forsknings- og udviklingsaktiviteter ved University College Lillebælt. Som introduktion til projektet indledes DEN AFSLUTTENDE RAPPORT DEL I med en sammenfatning og perspektivering af projektets resultater. Herefter præsenteres projektets...

  8. A potential role for immunotherapy in thyroid cancer by enhancing NY-ESO-1 cancer antigen expression.

    Science.gov (United States)

    Gunda, Viswanath; Frederick, Dennie T; Bernasconi, Maria J; Wargo, Jennifer A; Parangi, Sareh

    2014-08-01

    NY-ESO-1 is one of the most immunogenic members of the cancer/testis antigen family and its levels can be increased after exposure to demethylating and deacetylating agents. This cytoplasmic antigen can serve as a potent target for cancer immunotherapy and yet has not been well studied in differentiated thyroid cancer cells. We studied the baseline expression of NY-ESO-1 messenger RNA and protein before and after exposure to 5-aza-2'-deoxycytidine (DAC) (72 hours) in a panel of thyroid cancer cell lines using quantitative polymerase chain reaction and Western blot. HLA-A2+, NY-ESO-1+ thyroid cell lines were then co-cultured with peripheral blood lymphocytes transduced with NY-ESO-1 specific T-cell receptor (TCR) and assayed for interferon-gamma and Granzyme-B release in the medium. SCID mice injected orthotopically with BCPAP cells were treated with DAC to evaluate for NY-ESO-1 gene expression in vivo. None of the thyroid cancer cell lines showed baseline expression of NY-ESO-1. Three cell lines, BCPAP, TPC-1, and 8505c, showed an increase in NY-ESO-1 gene expression with DAC treatment and were found to be HLA-A2 positive. DAC-treated target BCPAP and TPC-1 tumor cells with up-regulated NY-ESO-1 levels were able to mount an appropriate interferon-gamma and Granzyme-B response upon co-culture with the NY-ESO-1-TCR-transduced peripheral blood lymphocytes. In vivo DAC treatment was able to increase NY-ESO-1 expression in an orthotopic mouse model with BCPAP cells. Our data suggest that many differentiated thyroid cancer cells can be pressed to express immune antigens, which can then be utilized in TCR-based immunotherapeutic interventions.

  9. 76 FR 43259 - Foreign-Trade Zone 109-Watertown, NY, Application for Manufacturing Authority, North American...

    Science.gov (United States)

    2011-07-20

    ...) with textile backing material for the U.S. market and export. The manufacturing process under FTZ..., North American Tapes, LLC, (Textile Athletic Tape), Watertown, NY A request has been submitted to the... textile fabrics (duty rates: 10.5, 14.9%). The facility can produce up to 12.5 million square meters of...

  10. 78 FR 51061 - Special Anchorage Areas; Port of New York, NY

    Science.gov (United States)

    2013-08-20

    ... convenient access to public transportation, onshore shopping and amenities which facilitate interstate and... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 110 RIN 1625-AA01 Special Anchorage Areas; Port of New York, NY AGENCY...

  11. Modelling dune erosion, overwash and breaching at Fire Island (NY) during hurricane Sandy

    NARCIS (Netherlands)

    De Vet, P.L.M.; McCall, R.T.; Den Bieman, J.P.; Stive, M.J.F.; Van Ormondt, M.

    2015-01-01

    In 2012, Hurricane Sandy caused a breach at Fire Island (NY, USA), near Pelican Island. This paper aims at modelling dune erosion, overwash and breaching processes that occured during the hurricane event at this stretch of coast with the numerical model XBeach. By using the default settings, the ero

  12. 33 CFR 110.156 - Randall Bay, Freeport, Long Island, N.Y.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Randall Bay, Freeport, Long Island, N.Y. 110.156 Section 110.156 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND....Y. (a) The anchorage grounds. Southward of a line 312 feet south of and parallel to the south...

  13. 78 FR 23845 - Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY

    Science.gov (United States)

    2013-04-23

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY AGENCY... the Smith Point Bridge, mile 6.1, across Narrow Bay, between Smith Point and Fire Island, New York. The deviation is necessary to facilitate the Smith Point Triathlon. This deviation allows the...

  14. 76 FR 60733 - Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY

    Science.gov (United States)

    2011-09-30

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY AGENCY... the Smith Point Bridge, 6.1, across Narrow Bay, between Smith Point and Fire Island, New York. The.... SUPPLEMENTARY INFORMATION: The Smith Point Bridge, across Narrow Bay, mile 6.1, between Smith Point and...

  15. Structural and magnetic properties of nanocomposite iron-containing SiCxNy films

    Science.gov (United States)

    Pushkarev, R. V.; Fainer, N. I.; Maurya, K. K.

    2017-02-01

    New ferromagnetic films with composition SiCxNyFez were synthesized using chemical vapor deposition technique. Films were deposited using ferrocene, 1,1,1,3,3,3-hexamethyldisilazane (HMDS) and hydrogen gaseous mixture. Chemical and phase composition of the films were studied by FTIR, Raman spectroscopy and X-ray diffraction with grazing incidence (GI-XRD). FTIR spectra analysis confirmed the existence of Si-C and Si-N bonds. Graphite inclusions and amorphous carbon were determined by Raman spectra analysis. The surface of the SiCxNyFez films studied by SEM is covered by nanocrystallites of iron oxide Fe3O4 phase. The main purpose of GI-XRD analysis is to describe the layered structure of the films in detail. It was shown by GI-XRD study, that phase composition of the SiCxNyFez films varies from iron oxide Fe3O4 to iron silicide Fe3Si and silicon carbide SiC with the deposition temperature growing. It was established, that SiCxNyFez films are perspective for application in the spintronic field.

  16. 76 FR 77175 - New York Fun Factory Fireworks Display, Western Long Island Sound; Mamaroneck, NY

    Science.gov (United States)

    2011-12-12

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 New York Fun Factory Fireworks Display, Western Long... Island Sound in the vicinity of Mamaroneck, NY in support of the New York Fun Factory Fireworks display... Guard to define regulatory safety zones. On May 10, 2012 New York Fun Factory Events is sponsoring...

  17. Den digitale patientmappe - et bud på en ny form for sundhedskommunikation i fysioterapeutisk praksis

    DEFF Research Database (Denmark)

    Duus, Lene

    2012-01-01

    Præsentation af et udviklingsprojekt, som jeg har deltaget i, hvor en ny form for sundhedskommunikation gennem en netbaseret digital patientmappe i fysioterapeutisk praksis har været afprøvet. Det overordnede mål for projektet var at bedre kommunikation, dokumentation og compliance for privatprak...

  18. 77 FR 74866 - Notice of Intent To Repatriate Cultural Items: New York State Museum, Albany, NY

    Science.gov (United States)

    2012-12-18

    ... belts. Seven of the wampum belts are on loan to the Seneca National Museum in Salamanca, NY, and one... Jemison on the Cattaraugus Reservation in New York. Mary Jemison was adopted by the Seneca as a child and chose to live her life as a Seneca. At the time of collection, the Five Nations Alliance Belt...

  19. 77 FR 30312 - Montezuma National Wildlife Refuge, Cayuga, Seneca, and Wayne Counties, NY; Draft Comprehensive...

    Science.gov (United States)

    2012-05-22

    ... notice in the Federal Register (75 FR 25286; May 7, 2010). Montezuma NWR was established in 1938 to... Fish and Wildlife Service Montezuma National Wildlife Refuge, Cayuga, Seneca, and Wayne Counties, NY... assessment (draft CCP/EA) for Montezuma National Wildlife Refuge (NWR), located in Cayuga, Seneca, and...

  20. 76 FR 3516 - Drawbridge Operation Regulations; Harlem River, New York City, NY

    Science.gov (United States)

    2011-01-20

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Harlem River, New York City, NY... of the 103rd Street (Wards Island) Bridge at mile 0.0, across the Harlem River, New York City, New... vessels, and commercial vessels of various sizes. The owner of the bridge, New York City Department of...

  1. 78 FR 35756 - Drawbridge Operation Regulations; Harlem River, New York City, NY

    Science.gov (United States)

    2013-06-14

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Harlem River, New York City, NY... of the Willis Avenue Bridge across the Harlem River, mile 1.5, at the Bronx, New York. The deviation... existing drawbridge operating regulations are found at 33 CFR 117.789(b)(2). The bridge owner, New York...

  2. 78 FR 23846 - Drawbridge Operation Regulations; Newtown Creek, New York City, NY

    Science.gov (United States)

    2013-04-23

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Newtown Creek, New York City, NY... of the Greenpoint Avenue Bridge across Newtown Creek, mile 1.3, at New York City, New York. The... are found at 33 CFR 117.801(g). The bridge owner, New York City Department of Transportation...

  3. 78 FR 36301 - CSX Transportation, Inc.-Discontinuance of Service Exemption-in Oswego County, NY

    Science.gov (United States)

    2013-06-17

    ... 0.85-mile rail line on CSXT's Northern Region, Albany Division, Fulton Subdivision, between milepost QMF 37.10 at the connection with CSXT's main line and milepost QMF 37.95 at the end of the track, in Oswego County, NY (the Line). The Line traverses United States Postal Service Zip Code 13126,...

  4. 78 FR 74009 - Safety Zone; Nike Fireworks, Upper New York Bay, Ellis Island, NY

    Science.gov (United States)

    2013-12-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 Safety Zone; Nike Fireworks, Upper New York Bay, Ellis Island, NY..., 2011 (76 FR 69614). ] Table 1 1. Nike Fireworks Ellis Launch site: A barge located Island Safety...

  5. 78 FR 71546 - Safety Zone; Belt Parkway Bridge Construction, Gerritsen Inlet, Brooklyn, NY

    Science.gov (United States)

    2013-11-29

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Belt Parkway Bridge Construction, Gerritsen Inlet, Brooklyn, NY AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast... Belt Parkway Bridge. This proposed rule would allow the Coast Guard to prohibit all vessel traffic...

  6. 76 FR 4529 - Safety Zone; Underwater Hazard, Gravesend Bay, Brooklyn, NY

    Science.gov (United States)

    2011-01-26

    ... 02'14'' W (NAD 83), approximately 70 yards southeast of the Verrazano Bridge Brooklyn tower. All... Bridge, Brooklyn, NY. This safety zone will not have a significant economic impact on a substantial...), approximately 70-yards southeast of the Verrazano Bridge Brooklyn tower. (b) Effective period. This regulation...

  7. 76 FR 34865 - Safety Zone; Rochester Harbor Festival, Genesee River, Rochester, NY

    Science.gov (United States)

    2011-06-15

    ... impracticable and contrary to the public interest. Background and Purpose The Rochester Harbor Festival is an... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Rochester Harbor Festival, Genesee River... establishing a temporary safety zone on the Genesee River, Rochester, NY for the Rochester Harbor Festival...

  8. 77 FR 52058 - Notice of Inventory Completion: American Museum of Natural History, New York, NY; Correction

    Science.gov (United States)

    2012-08-28

    ... National Park Service Notice of Inventory Completion: American Museum of Natural History, New York, NY... completion of an inventory of human remains in the possession of the American Museum of Natural History, New... following sentence: Officials of the American Museum of Natural History have determined that, pursuant to...

  9. 76 FR 43712 - Notice of Inventory Completion: American Museum of Natural History, New York, NY

    Science.gov (United States)

    2011-07-21

    ... National Park Service Notice of Inventory Completion: American Museum of Natural History, New York, NY AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The American Museum of Natural History... human remains may contact the American Museum of Natural History. Repatriation of the human remains...

  10. NY-ESO-1 expression in DCIS: A new predictor of good prognosis.

    Science.gov (United States)

    Coombes, R Charles; Caballero, Otavia L; Shousha, Sami; Ghaem-Maghami, Sadaf; Woodley-Barker, Laura; Wilhelm-Benartzi, Charlotte S; Neville, A Munro

    2017-03-01

    At present, it is difficult to predict which patients with ductal carcinoma-in-situ (DCIS) will subsequently develop frank invasive breast cancer (IDC). A recent survey by our group has shown that NY-ESO-1 and MAGEA are both expressed in DCIS. This study was aimed at determining whether expression of these antigens was related to the later development of IDC. 14 of 42 (33%) of patients developed invasive breast cancer during the follow up period. Only one of those DCIS cases that relapsed was positive for NYESO-1 at diagnosis. In contrast, DCIS samples of 15 of the 28 (54%) of those patients who remained disease-free expressed NY-ESO-1. (Permutation chi square p=0.0033). We identified 42 patients with DCIS, and followed them up for more than 10 years. NY-ESO-1 and MAGEA were demonstrated by immunostaining as were CD8+ infiltrates on all sections together with the conventional markers, ER, PR, and HER2. Expression of NY-ESO-1 may predict those patients who will not subsequently develop invasive breast cancer and could therefore potentially be helpful in defining prognosis in patients with DCIS.

  11. 77 FR 46349 - Safety Zone; DeStefano Wedding Fireworks Display, Patchogue Bay, Patchogue, NY

    Science.gov (United States)

    2012-08-03

    ... significant environmental impact from this proposed rule. List of Subjects in 33 CFR Part 165 Harbors, Marine... Bay'' restaurant in Patchogue, NY. This rule will be effective from 8:30 p.m. on November 3, 2012... Broadcast Notice to Mariners. 2. Impact on Small Entities Under the Regulatory Flexibility Act (5 U.S.C....

  12. 75 FR 13454 - Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY

    Science.gov (United States)

    2010-03-22

    ... Federal Register (73 FR 3316). Public Meeting We do not plan to hold a public meeting. But you may submit...-2009-0520) in the Federal Register (74 FR 51243). No comments or requests for meetings were received... Championships, Huntington Bay, NY AGENCY: Coast Guard, DHS. ACTION: Supplemental Notice of proposed...

  13. NY Serpentis: SU UMa-type nova in the period gap with diversity of normal outbursts

    Science.gov (United States)

    Pavlenko, Elena P.; Kato, Taichi; Antonyuk, Oksana I.; Ohshima, Tomohito; Hambsch, Franz-Josef; Antonyuk, Kirill A.; Sosnovskij, Aleksei A.; Baklanov, Alex V.; Shugarov, Sergey Yu.; Pit, Nikolaj V.; Nakata, Chikako; Masi, Gianluca; Nakajima, Kazuhiro; Maehara, Hiroyuki; Dubovsky, Pavol A.; Kudzej, Igor; Andreev, Maksim V.; Kuznyetsova, Yuliana G.; Vasiliskov, Kirill A.

    2014-12-01

    We present a photometric study of NY Ser, an in-the-gap SU UMa-type nova, in 2002 and 2013. We determined the duration of its superoutburst and the mean period of its superhump are 18 d and 0.10458 d, respectively. We detected in 2013 that NY Ser showed two distinct states separated by a superoutburst. A state of rather infrequent normal outbursts lasted at least 44 d before the superoutburst, and a state of frequent outbursts started immediately after the superoutburst and lasted at least 34 d. Unlike a typical SU UMa star with a bimodal distribution of outburst duration, NY Ser displayed a diversity of normal outbursts. In the state of infrequent outbursts, we detected a wide ˜ 12 d outburst accompanied by 0.098 d orbital modulation but without superhumps ever established in NY Ser. We classified this as a "wide normal outburst." The orbital period was dominant both in quiescence and during normal outbursts in this state. In the state of the most frequent normal outbursts, the 0.10465 d positive superhump period was dominant and coexisted with the orbital modulation. In 2002 we detected the normal outburst of "intermediate" 5-6 d duration that was also accompanied by orbital modulations.

  14. 75 FR 15739 - International Business Machines Corporation: Armonk, NY; Notice of Termination of Investigation

    Science.gov (United States)

    2010-03-30

    ... Employment and Training Administration International Business Machines Corporation: Armonk, NY; Notice of... was initiated in response to a petition filed on May 21, 2009 on behalf of workers of International Business Machines Corporation, Armonk, New York. The petitioning group of workers is covered by...

  15. Nematodes from rocky grassland in Börzsöny Mountains, Hungary

    OpenAIRE

    Kiss, M

    2011-01-01

    This paper reports on investigations carried out on soil inhabiting nematodes living in andesitic rock regions ofBörzsöny Mountains. Seventeen species are listed. Heterodorus arcuatus (Thorne, 1939), new to the fauna of Hungary, isdescribed and illustrated in detail.

  16. Nematodes from rocky grassland in Börzsöny Mountains, Hungary

    Directory of Open Access Journals (Sweden)

    Kiss, M.

    2011-06-01

    Full Text Available This paper reports on investigations carried out on soil inhabiting nematodes living in andesitic rock regions ofBörzsöny Mountains. Seventeen species are listed. Heterodorus arcuatus (Thorne, 1939, new to the fauna of Hungary, isdescribed and illustrated in detail.

  17. 77 FR 41271 - Safety Zone; Newburgh to Beacon Swim, Newburgh, Hudson River, NY

    Science.gov (United States)

    2012-07-13

    ... Acronyms DHS Department of Homeland Security FR Federal Register CFR Code of Federal Regulations NPRM... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Newburgh to Beacon Swim, Newburgh, Hudson... Newburgh, NY for the annual Newburgh Beacon Swim event. This temporary safety zone is necessary to...

  18. 77 FR 834 - Noise Exposure Map Update for Albany International Airport, Albany, NY

    Science.gov (United States)

    2012-01-06

    ... Federal Aviation Administration Noise Exposure Map Update for Albany International Airport, Albany, NY... Administration (FAA) announces its determination that the updated noise exposure maps submitted by the Albany.... 47501 et. seq (Aviation Safety and Noise Abatement Act) and 14 CFR part 150 are in compliance...

  19. 77 FR 51614 - CSX Transportation, Inc.-Abandonment Exemption-in Niagara County, NY

    Science.gov (United States)

    2012-08-24

    ... Abandonments to abandon a 0.1-mile rail line on its Northern Region, Albany Division, Niagara Subdivision, between milepost QDN 28.0 near North Avenue to the end of the track at milepost QDN 28.1, in Niagara Falls... Surface Transportation Board CSX Transportation, Inc.--Abandonment Exemption--in Niagara County, NY...

  20. 77 FR 41048 - Safety Zone; Hudson Valley Triathlon, Ulster Landing, Hudson River, NY

    Science.gov (United States)

    2012-07-12

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Hudson Valley Triathlon, Ulster Landing... Landing, NY for the 16th Annual Hudson Valley Triathlon swim event. This temporary safety zone is.... Regulatory History and Information The Hudson Valley Triathlon swim is an annual recurring event that has...

  1. 75 FR 11937 - Eagle Sportswear, Inc.; New York, NY; Notice of Termination of Investigation

    Science.gov (United States)

    2010-03-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Eagle Sportswear, Inc.; New York, NY; Notice of Termination of... response to a petition filed on December 4, 2009 by a company official on behalf of workers of...

  2. Influence of residual stress on the phase equilibrium of Ti(CxNy) thin films

    Institute of Scientific and Technical Information of China (English)

    Ying Jin; Changrong Li; Xiaoyan Ma; Zhenmin Du; Weijing Zhang; J.-C. Tedenac

    2003-01-01

    In order to provide a theoretic basis for the research of Ti(CxNy) thin films, the thermodynamic database of Ti-C-N ternary system is established and the phase diagram sections are calculated. In addition to the assessed thermodynamic properties of Ti-C-N system, the influence of the residual strain energy of Ti(CxNy) thin films on the phase equilibria is analyzed. The classical formula for calculating the elastic strain energy is expressed into a Redlich-Kister form in order to perform the thermodynamic and equilibrium calculations using the Thermo-Calc software. Isothermal sections at 900 and 1100 K are calculated with this database and compared with those calculated without considering the residual stress. As a result, with the addition of strain energy δ-fcc Ti(CxNy) phase area shrinks. It is therefore concluded that with the influence of the residual stress in Ti(CxNy) thin solid film, the precipitation of pure δ film requires more precise control of composition.

  3. Modelling dune erosion, overwash and breaching at Fire Island (NY) during hurricane Sandy

    NARCIS (Netherlands)

    De Vet, P.L.M.; McCall, R.T.; Den Bieman, J.P.; Stive, M.J.F.; Van Ormondt, M.

    2015-01-01

    In 2012, Hurricane Sandy caused a breach at Fire Island (NY, USA), near Pelican Island. This paper aims at modelling dune erosion, overwash and breaching processes that occured during the hurricane event at this stretch of coast with the numerical model XBeach. By using the default settings, the

  4. 77 FR 38492 - Safety Zone; Olcott Fireworks, Lake Ontario, Olcott, NY

    Science.gov (United States)

    2012-06-28

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Olcott Fireworks, Lake Ontario, Olcott, NY... temporary safety zone on Lake Ontario, Olcott, New York. This safety zone is intended to restrict vessels from a portion of Lake Ontario during the Olcott fireworks on July 3, 2012. The safety zone...

  5. Tumor-infiltrating T cells correlate with NY-ESO-1-specific autoantibodies in ovarian cancer.

    Directory of Open Access Journals (Sweden)

    Katy Milne

    Full Text Available BACKGROUND: Tumor-infiltrating CD8+ T cells are correlated with prolonged progression-free and overall survival in epithelial ovarian cancer (EOC. A significant fraction of EOC patients mount autoantibody responses to various tumor antigens, however the relationship between autoantibodies and tumor-infiltrating T cells has not been investigated in EOC or any other human cancer. We hypothesized that autoantibody and T cell responses may be correlated in EOC and directed toward the same antigens. METHODOLOGY AND PRINCIPAL FINDINGS: We obtained matched serum and tumor tissue from 35 patients with high-grade serous ovarian cancer. Serum samples were assessed by ELISA for autoantibodies to the common tumor antigen NY-ESO-1. Tumor tissue was examined by immunohistochemistry for expression of NY-ESO-1, various T cell markers (CD3, CD4, CD8, CD25, FoxP3, TIA-1 and Granzyme B and other immunological markers (CD20, MHC class I and MHC class II. Lymphocytic infiltrates varied widely among tumors and included cells positive for CD3, CD8, TIA-1, CD25, FoxP3 and CD4. Twenty-six percent (9/35 of patients demonstrated serum IgG autoantibodies to NY-ESO-1, which were positively correlated with expression of NY-ESO-1 antigen by tumor cells (r = 0.57, p = 0.0004. Autoantibodies to NY-ESO-1 were associated with increased tumor-infiltrating CD8+, CD4+ and FoxP3+ cells. In an individual HLA-A2+ patient with autoantibodies to NY-ESO-1, CD8+ T cells isolated from solid tumor and ascites were reactive to NY-ESO-1 by IFN-gamma ELISPOT and MHC class I pentamer staining. CONCLUSION AND SIGNIFICANCE: We demonstrate that tumor-specific autoantibodies and tumor-infiltrating T cells are correlated in human cancer and can be directed against the same target antigen. This implies that autoantibodies may collaborate with tumor-infiltrating T cells to influence clinical outcomes in EOC. Furthermore, serological screening methods may prove useful for identifying clinically relevant

  6. The tubulin-bound conformation of paclitaxel: T-taxol vs "PTX-NY".

    Science.gov (United States)

    Yang, Yutao; Alcaraz, Ana A; Snyder, James P

    2009-03-27

    Nearly 35 years after its discovery and 11 years after FDA approval of paclitaxel (PTX) as a breakthrough anticancer drug, the 3-D structure of the agent bound to its beta-tubulin target was proposed to be T-Taxol. The latter bioactive form has recently been challenged by the Ojima group with a structure, "PTX-NY" ("REDOR Taxol"), in which the C-13 side chain is proposed to adopt a different conformation and an alternative hydrogen-bonding pattern in the tubulin binding site. Previously, the two conformers were compared to show that only T-Taxol fits the PTX-derived electron crystallographic density. That work has been extended by molecular mechanics and quantum chemical methods to reveal that the PTX-NY conformation is relatively less stable, on average, by 10-11 kcal/mol. In agreement with NMR studies, an 11 ns molecular dynamics treatment for PTX in an explicit water pool locates T-Taxol along the trajectory, but not PTX-NY. Docking of various PTX conformers into the electron crystallographic binding site of tubulin demonstrates that PTX-NY cannot be accommodated unless the pocket is reorganized in violation of the experimental constraints. Finally, analysis of the structures of T-Taxol and PTX-NY for their capacity to predict the existence of superpotent PTX analogues discloses that only the former forecasts such analogues, as now established by the T-Taxol-inspired synthesis of bridged taxanes. In sum, all empirical criteria support T-Taxol as the bound conformation of PTX on beta-tubulin in microtubules.

  7. NY-BR-1 protein expression in breast carcinoma: a mammary gland differentiation antigen as target for cancer immunotherapy.

    Science.gov (United States)

    Theurillat, Jean-Philippe; Zürrer-Härdi, Ursina; Varga, Zsuzsanna; Storz, Martina; Probst-Hensch, Nicole M; Seifert, Burkhardt; Fehr, Mathias K; Fink, Daniel; Ferrone, Soldano; Pestalozzi, Bernhard; Jungbluth, Achim A; Chen, Yao-Tseng; Jäger, Dirk; Knuth, Alexander; Moch, Holger

    2007-11-01

    NY-BR-1 is a recently identified differentiation antigen of the mammary gland. To use NY-BR-1 for T-cell-based immunotherapy, analysis of its co-expression with HLA class I antigens is required. In the present tissue microarray study, primary breast cancers (n = 1,444), recurrences (n = 88), lymph node (n = 525) and distant metastases (n = 91) were studied for NY-BR-1 expression using a novel monoclonal antibody. NY-BR-1 expression was compared with prognosis, estrogen receptor, HER2-status, EGFR and HLA class I antigen expression. NY-BR-1 was more frequently expressed in grade 1 (82%) than in grade 2 (69%) and grade 3 (46%) carcinomas (P < 0.0001). Moreover, NY-BR-1 expression correlated directly with estrogen receptor expression (P < 0.0001) and inversely correlated with HER2-status and EGFR expression (P < 0.0001 for both). Considering high expression level of co-expression, 198/1,321 (15%) primary breast carcinomas and 4/65 (6%) distant metastases expressed NY-BR-1 and HLA class I, suggesting that active immunotherapy can be applied to about 10% of breast cancer patients. Survival analysis showed an association of NY-BR-1 expression with better patient outcome (P = 0.015). No difference between NY-BR-1 expression of primary tumors and metastases could be found, indicating that the presence of NY-BR-1 in metastases can be deduced from their corresponding primary. Forty-three paired biopsies taken from patients before and after chemotherapy suggest that NY-BR-1 expression is not influenced by preceding chemotherapy (kappa = 0.89, P < 0.0001). In summary, the co-expression of NY-BR-1 with HLA class I antigens and its expression in metastases without modification by chemotherapy suggest that NY-BR-1 targeted immunotherapy represents a viable strategy in addition to other targeted cancer drug therapies of breast cancer.

  8. 重组腺病毒载体pAd-NY-ESO-1-EGFP的构建及鉴定%Construction and Identification of Recombinant Adenovirns Vector Containing NY-ESO-1 Gene

    Institute of Scientific and Technical Information of China (English)

    张又莉; 徐少勇; 王家宁; 黄永章; 王斌; 宋军; 郭凌郧

    2008-01-01

    目的:利用细菌内同源重组法构建含人肿瘤特异性抗原的腺病毒质粒.方法:设计NY-ESO-1 cDNA扩增引物,从pETl5b-NY-ESO-1质粒中扩增NY-ESO-1的DNA序列,与pShuttle-IRES-hrGFP-2进行连接,PCR和EcoRV酶切鉴定重组质粒pShuttle-NY-ESO-1-EGFP,经Pme I酶切线性化后,转化含pAdeasy-1的超感受态BJ5183大肠杆菌,细菌内同源重组法构建腺病毒质粒pAd-NY-ESO-1-EGFP;质粒经Pac I酶切鉴定,DNA测序.结果:线性化的pShuttle-NY-ESO-1-EGFP转化含pAdeasy-1的超感受态BJ5183大肠杆菌,重组质粒经酶切获得一大于23 kb的大片段和4.5kb的片段,PCR反应扩增出了340 bp的片段.结论:用细菌内同源重组法成功地构建了含NY-ESO-1的重组腺病毒质粒,为进行表达NY-ESO-1的重组腺病毒的制备及肿瘤特异性抗原NY-ESO-1的核酸疫苗在肿瘤方面的研究奠定了基础.

  9. Macronutrient contributions of insects to the diets of hunter-gatherers: a geometric analysis.

    Science.gov (United States)

    Raubenheimer, David; Rothman, Jessica M; Pontzer, Herman; Simpson, Stephen J

    2014-06-01

    We present a geometric model for examining the macronutrient contributions of insects in the diets of pre-agricultural humans, and relate the findings to some contemporary societies that regularly eat insects. The model integrates published data on the macronutrient composition of insects and other foods in the diets of humans, recommended human macronutrient intakes, and estimated macronutrient intakes to examine the assumption that insects provided to pre-agricultural humans an invertebrate equivalent of vertebrate-derived meats, serving primarily as a source of protein. Our analysis suggests that insects vary more widely in their macronutrient content than is likely to be the case for most wild vertebrate meats, spanning a broad range of protein, fat and carbohydrate concentrations. Potentially, therefore, in terms of their proportional macronutrient composition, insects could serve as equivalents not only of wild meat, but of a range of other foods including some shellfish, nuts, pulses, vegetables and even fruits. Furthermore, humans might systematically manipulate the composition of edible insects to meet specific needs through pre-ingestive processing, such as cooking and selective removal of body parts. We present data suggesting that in modern societies for which protein is the more limiting macronutrient, pre-ingestive processing of edible insects might serve to concentrate protein. It is likely, however, that the dietary significance of insects was different for Paleolithic hunter-gatherers who were more limited in non-protein energy. Our conclusions are constrained by available data, but highlight the need for further studies, and suggest that our model provides an integrative framework for conceiving these studies. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. PLANET HUNTERS. VIII. CHARACTERIZATION OF 41 LONG-PERIOD EXOPLANET CANDIDATES FROM KEPLER ARCHIVAL DATA

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Ji; Fischer, Debra A.; Picard, Alyssa; Schmitt, Joseph R.; Boyajian, Tabetha S. [Department of Astronomy, Yale University, New Haven, CT 06511 (United States); Barclay, Thomas [NASA Ames Research Center, M/S 244-30, Moffett Field, CA 94035 (United States); Ma, Bo [Department of Astronomy, University of Florida, 211 Bryant Space Science Center, Gainesville, FL 32611-2055 (United States); Bowler, Brendan P.; Riddle, Reed [California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91101 (United States); Jek, Kian J.; LaCourse, Daryll; Simister, Dean Joseph; Grégoire, Boscher; Babin, Sean P.; Poile, Trevor; Jacobs, Thomas Lee; Baranec, Christoph [Institute for Astronomy, University of Hawai‘i at Mānoa, Hilo, HI 96720-2700 (United States); Law, Nicholas M. [Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3255 (United States); Lintott, Chris [Oxford Astrophysics, Denys Wilkinson Building, Keble Road, Oxford OX1 3RH (United Kingdom); Schawinski, Kevin [Institute for Astronomy, Department of Physics, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093 Zurich (Switzerland); and others

    2015-12-20

    The census of exoplanets is incomplete for orbital distances larger than 1 AU. Here, we present 41 long-period planet candidates in 38 systems identified by Planet Hunters based on Kepler archival data (Q0–Q17). Among them, 17 exhibit only one transit, 14 have two visible transits, and 10 have more than three visible transits. For planet candidates with only one visible transit, we estimate their orbital periods based on transit duration and host star properties. The majority of the planet candidates in this work (75%) have orbital periods that correspond to distances of 1–3 AU from their host stars. We conduct follow-up imaging and spectroscopic observations to validate and characterize planet host stars. In total, we obtain adaptive optics images for 33 stars to search for possible blending sources. Six stars have stellar companions within 4″. We obtain high-resolution spectra for 6 stars to determine their physical properties. Stellar properties for other stars are obtained from the NASA Exoplanet Archive and the Kepler Stellar Catalog by Huber et al. We validate 7 planet candidates that have planet confidence over 0.997 (3σ level). These validated planets include 3 single-transit planets (KIC-3558849b, KIC-5951458b, and KIC-8540376c), 3 planets with double transits (KIC-8540376b, KIC-9663113b, and KIC-10525077b), and 1 planet with four transits (KIC-5437945b). This work provides assessment regarding the existence of planets at wide separations and the associated false positive rate for transiting observation (17%–33%). More than half of the long-period planets with at least three transits in this paper exhibit transit timing variations up to 41 hr, which suggest additional components that dynamically interact with the transiting planet candidates. The nature of these components can be determined by follow-up radial velocity and transit observations.

  11. Planet Hunters: A Transiting Circumbinary Planet in a Quadruple Star System

    Science.gov (United States)

    Schwamb, Megan E.; Orosz, Jerome A.; Carter, Joshua A.; Welsh, William F.; Fischer, Debra A.; Torres, Guillermo; Howard, Andrew W.; Crepp, Justin R.; Keel, William C.; Lintott, Chris J.; Kaib, Nathan A.; Terrell, Dirk; Gagliano, Robert; Jek, Kian J.; Parrish, Michael; Smith, Arfon M.; Lynn, Stuart; Simpson, Robert J.; Giguere, Matthew J.; Schawinski, Kevin

    2013-05-01

    We report the discovery and confirmation of a transiting circumbinary planet (PH1b) around KIC 4862625, an eclipsing binary in the Kepler field. The planet was discovered by volunteers searching the first six Quarters of publicly available Kepler data as part of the Planet Hunters citizen science project. Transits of the planet across the larger and brighter of the eclipsing stars are detectable by visual inspection every ~137 days, with seven transits identified in Quarters 1-11. The physical and orbital parameters of both the host stars and planet were obtained via a photometric-dynamical model, simultaneously fitting both the measured radial velocities and the Kepler light curve of KIC 4862625. The 6.18 ± 0.17 R ⊕ planet orbits outside the 20 day orbit of an eclipsing binary consisting of an F dwarf (1.734 ± 0.044 R ⊙, 1.528 ± 0.087 M ⊙) and M dwarf (0.378 ± 0.023 R ⊙, 0.408 ± 0.024 M ⊙). For the planet, we find an upper mass limit of 169 M ⊕ (0.531 Jupiter masses) at the 99.7% confidence level. With a radius and mass less than that of Jupiter, PH1b is well within the planetary regime. Outside the planet's orbit, at ~1000 AU, a previously unknown visual binary has been identified that is likely bound to the planetary system, making this the first known case of a quadruple star system with a transiting planet.

  12. Knowledge-Sharing Networks in Hunter-Gatherers and the Evolution of Cumulative Culture.

    Science.gov (United States)

    Salali, Gul Deniz; Chaudhary, Nikhil; Thompson, James; Grace, Olwen Megan; van der Burgt, Xander M; Dyble, Mark; Page, Abigail E; Smith, Daniel; Lewis, Jerome; Mace, Ruth; Vinicius, Lucio; Migliano, Andrea Bamberg

    2016-09-26

    Humans possess the unique ability for cumulative culture [1, 2]. It has been argued that hunter-gatherer's complex social structure [3-9] has facilitated the evolution of cumulative culture by allowing information exchange among large pools of individuals [10-13]. However, empirical evidence for the interaction between social structure and cultural transmission is scant [14]. Here we examine the reported co-occurrence of plant uses between individuals in dyads (which we define as their "shared knowledge" of plant uses) in BaYaka Pygmies from Congo. We studied reported uses of 33 plants of 219 individuals from four camps. We show that (1) plant uses by BaYaka fall into three main domains: medicinal, foraging, and social norms/beliefs; (2) most medicinal plants have known bioactive properties, and some are positively associated with children's BMI, suggesting that their use is adaptive; (3) knowledge of medicinal plants is mainly shared between spouses and biological and affinal kin; and (4) knowledge of plant uses associated with foraging and social norms is shared more widely among campmates, regardless of relatedness, and is important for camp-wide activities that require cooperation. Our results show the interdependence between social structure and knowledge sharing. We propose that long-term pair bonds, affinal kin recognition, exogamy, and multi-locality create ties between unrelated families, facilitating the transmission of medicinal knowledge and its fitness implications. Additionally, multi-family camps with low inter-relatedness between camp members provide a framework for the exchange of functional information related to cooperative activities beyond the family unit, such as foraging and regulation of social life.

  13. The spatial structure of hunter access determines the local abundance of forest elephants (Loxodonta africana cyclotis).

    Science.gov (United States)

    Yackulic, Charles B; Strindberg, Samantha; Maisels, Fiona; Blake, Stephen

    2011-06-01

    In many previously remote regions in the world, increasing and often unregulated access is leading to dramatic increases in hunting pressure and declines in the densities of prey species, sometimes to the point of local extinction. Not surprisingly, numerous studies have found a correlation between the distance to the closest access point and prey densities. Here we hypothesized that, for many wide-ranging species, local abundances are reduced by hunting associated with multiple access points as opposed to just the closest access points. We also hypothesized that the distribution of hunter access determines both patterns of occupancy and abundance in occupied areas and that these two patterns (occupancy and abundance) respond to access at different spatial scales. Using data on the distribution of abundances of African forest elephant (Loxodonta africana cyclotis) in and around five national parks in Central Africa, we tested these hypotheses using a model comparison framework. We found that models including an index based on the distance to multiple roads outperformed models including other access-based covariates, including a model based on distance to the closest road only. We also found that models that allowed us to model occupancy and abundance separately outperformed simpler models. Occupancy responds to access at the same scale as previous estimates of average maximum displacement in the subspecies, while the scale of the response of abundance is more ambiguous, but appears to be greater. Lastly, we show that incorporating indices based on multiple access points and modeling abundance and occupancy has important practical consequences for our understanding of overall regional abundances and the distribution of abundances within regions.

  14. Polymeric Structure and Host Toll-like Receptor 4 Dictate Immunogenicity of NY-ESO-1 Antigen in Vivo*

    Science.gov (United States)

    Liu, Yanan; Tian, Xiaoli; Leitner, Wolfgang W.; Aldridge, Michael E.; Zheng, Junying; Yu, Zhiya; Restifo, Nicholas P.; Weiss, Richard; Scheiblhofer, Sandra; Xie, Chong; Sun, Ren; Cheng, Genhong; Zeng, Gang

    2011-01-01

    In search of intrinsic factors that contribute to the distinctively strong immunogenicity of a non-mutated cancer/testis antigen, we found that NY-ESO-1 forms polymeric structures through disulfide bonds. NY-ESO-1 binding to immature dendritic cells was dependent on its polymeric structure and involved Toll-like receptor-4 (TLR4) on the surface of immature dendritic cells in mouse and human. Gene gun-delivered plasmid encoding the wild-type NY-ESO-1 readily induced T cell-dependent antibody (Ab) responses in wild-type C57BL/10 mice but not TLR4-knock-out C57BL/10ScNJ mice. Disrupting polymeric structures of NY-ESO-1 by cysteine-to-serine (Cys-to-Ser) substitutions lead to diminished immunogenicity and altered TLR4-dependence in the induced Ab response. To demonstrate its adjuvant effect, NY-ESO-1 was fused with a major mugwort pollen allergen Art v 1 and a tumor-associated antigen, carbonic anhydrase 9. Plasmid DNA vaccines encoding the fusion genes generated robust immune responses against otherwise non-immunogenic targets in mice. Polymeric structure and TLR4 may play important roles in rendering NY-ESO-1 immunogenic and thus serve as a potent molecular adjuvant. NY-ESO-1 thus represents the first example of a cancer/testis antigen that is a also damage-associated molecular pattern. PMID:21900253

  15. Polymeric structure and host Toll-like receptor 4 dictate immunogenicity of NY-ESO-1 antigen in vivo.

    Science.gov (United States)

    Liu, Yanan; Tian, Xiaoli; Leitner, Wolfgang W; Aldridge, Michael E; Zheng, Junying; Yu, Zhiya; Restifo, Nicholas P; Weiss, Richard; Scheiblhofer, Sandra; Xie, Chong; Sun, Ren; Cheng, Genhong; Zeng, Gang

    2011-10-28

    In search of intrinsic factors that contribute to the distinctively strong immunogenicity of a non-mutated cancer/testis antigen, we found that NY-ESO-1 forms polymeric structures through disulfide bonds. NY-ESO-1 binding to immature dendritic cells was dependent on its polymeric structure and involved Toll-like receptor-4 (TLR4) on the surface of immature dendritic cells in mouse and human. Gene gun-delivered plasmid encoding the wild-type NY-ESO-1 readily induced T cell-dependent antibody (Ab) responses in wild-type C57BL/10 mice but not TLR4-knock-out C57BL/10ScNJ mice. Disrupting polymeric structures of NY-ESO-1 by cysteine-to-serine (Cys-to-Ser) substitutions lead to diminished immunogenicity and altered TLR4-dependence in the induced Ab response. To demonstrate its adjuvant effect, NY-ESO-1 was fused with a major mugwort pollen allergen Art v 1 and a tumor-associated antigen, carbonic anhydrase 9. Plasmid DNA vaccines encoding the fusion genes generated robust immune responses against otherwise non-immunogenic targets in mice. Polymeric structure and TLR4 may play important roles in rendering NY-ESO-1 immunogenic and thus serve as a potent molecular adjuvant. NY-ESO-1 thus represents the first example of a cancer/testis antigen that is a also damage-associated molecular pattern.

  16. Preclinical safety pharmacology study of a novel protein-based cancer vaccine CHP-NY-ESO-1.

    Science.gov (United States)

    Harada, Naozumi; Hoshiai, Kiyotaka; Takahashi, Yoshiyasu; Sakaguchi, Yasue; Kuno, Takayoshi; Hishida, Tadashi; Shiku, Hiroshi

    2008-05-23

    CHP-NY-ESO-1 is a novel therapeutic cancer vaccine consisting of a recombinant protein of cancer antigen NY-ESO-1 and a polysaccharide-based delivery system, cholesteryl pullulan. A pilot clinical study of CHP-NY-ESO-1 in cancer patients was previously conducted, and the adverse events related to this drug were observed to be limited to skin reactions at injection sites. To further establish the safety of CHP-NY-ESO-1, we studied the effects of its subcutaneous injection on vital functions such as the central nervous system, cardiovascular system and respiratory system using preclinical animal models. The effects of CHP-NY-ESO-1 on the cardiovascular system were investigated in dogs using a telemetry system for blood pressure and heart rate and the Holter monitoring for ambulatory electrocardiograms. No drug-related changes were observed in these parameters. The effect of CHP-NY-ESO-1 on the hERG-dependent potassium currents was also examined using in vitro cultured cell system, and no inhibition of hERG currents was observed. The effects of CHP-NY-ESO-1 on the central nervous system were examined in rats using functional observational battery method, and no drug-related changes were observed in home cage observations, open field observations, hand held observations, and perception and motor function observations. The effect of CHP-NY-ESO-1 on the respiratory system was investigated in rats by measuring tidal volume, minute volume and respiratory rate using whole-body plethysmograph method, and no significant changes were found in these parameters. These results indicate that CHP-NY-ESO-1 would not have any pharmacological effects on vital functions and support the safety of this cancer vaccine for clinical use.

  17. Enhancing whole-tumor cell vaccination by engaging innate immune system through NY-ESO-1/dendritic cell interactions.

    Science.gov (United States)

    Xu, Le; Zheng, Junying; Nguyen, David H; Luong, Quang T; Zeng, Gang

    2013-10-01

    NY-ESO-1 is a cancer/germline antigen (Ag) with distinctively strong immunogenicity. We have previously demonstrated that NY-ESO-1 serves as an endogenous adjuvant by engaging dendritic cell (DC)-surface receptors of calreticulin (CRT) and toll-like receptor (TLR) 4. In the present study, NY-ESO-1 was investigated for its immunomodulatory roles as a molecular adjuvant in whole-tumor cell vaccines using the Renca kidney cancer model. Renca cells were genetically engineered to express NY-ESO-1 on the cell surface to enhance direct interactions with DC. The effect of ectopic cell-surface expression of NY-ESO-1 was investigated on tumor immunogenicity, DC activation, cytotoxic T lymphocytes against model tumor-associated Ags, and the effectiveness of the modified tumor cells as a therapeutic whole-cell vaccine. Cell-surface expression of NY-ESO-1 was able to reduce the tumor growth of Renca cells in BALB/c mice, although the modification did not alter cell proliferation rate in vitro. Directly engaging the innate immune system through NY-ESO-1 facilitated the interaction of tumor cells with DC, leading to enhanced DC activation and subsequent tumor-specific T-cell priming. When used as a therapeutic whole-cell vaccine, Renca cells with NY-ESO-1 on the surface mediated stronger inhibitory effects on tumor growth and metastasis compared with parental Renca or Renca cells expressing a control protein GFP on the surface. Augmented antitumor efficacy correlated with increased CD8 T-cell infiltration into tumors and decreased myeloid-derived suppressor cells and regulatory T cells in the spleen. As a cancer/germline Ag and as an immunomodulatory adjuvant through engaging innate immune receptors, NY-ESO-1 offers a unique opportunity for improved whole-tumor cell vaccinations upon the classic GM-CSF-engineered cell vaccines.

  18. NY-ESO-1 is a ubiquitous immunotherapeutic target antigen for patients with myxoid/round cell liposarcoma.

    Science.gov (United States)

    Pollack, Seth M; Jungbluth, Achim A; Hoch, Benjamin L; Farrar, Erik A; Bleakley, Marie; Schneider, David J; Loggers, Elizabeth T; Rodler, Eve; Eary, Janet F; Conrad, Ernest U; Jones, Robin L; Yee, Cassian

    2012-09-15

    Myxoid/round cell liposarcoma (MRCL) is the second most common liposarcoma subtype, accounting for >33% of liposarcomas and approximately 10% of all soft tissue sarcomas. Although MRCL is a chemosensitive subtype, patients with metastatic disease have a poor outcome. NY-ESO-1 is a cancer-testis antigen (also known as cancer germ cell antigen) that has been successfully targeted in vaccine trials and in adoptive T-cell therapy trials for the treatment of several solid tumors. The authors investigated the feasibility of targeting NY-ESO-1 in patients with MRCL by evaluating the prevalence of NY-ESO-1 expression in tumors using immunohistochemistry and quantitative reverse transcriptase-polymerase chain reaction analysis. NY-ESO-1-specific tumor recognition by NY-ESO-1-specific T-cells also was analyzed using a chromium release assay. A search of the University of Washington Sarcoma Tissue Bank identified paraffin-embedded tumor samples from 25 patients with MRCL. NY-ESO-1 expression was observed in every MRCL tumor assessed (100%); in 18 tumors (72%), staining was homogenous. In all but 2 tumors, staining was sufficiently robust (2+) that such patients would be eligible for clinical trials of NY-ESO-1-directed therapy. By using NY-ESO-1 specific, CD8-positive T-cells, the in vitro sensitivity of myxoid liposarcoma cell lines to antigen-specific lysis was demonstrated. The current results establish NY-ESO-1 as an important target antigen for the treatment of patients with MRCL. Copyright © 2012 American Cancer Society.

  19. Effector memory and central memory NY-ESO-1-specific re-directed T cells for treatment of multiple myeloma.

    Science.gov (United States)

    Schuberth, P C; Jakka, G; Jensen, S M; Wadle, A; Gautschi, F; Haley, D; Haile, S; Mischo, A; Held, G; Thiel, M; Tinguely, M; Bifulco, C B; Fox, B A; Renner, C; Petrausch, U

    2013-04-01

    The cancer-testis antigen NY-ESO-1 is a potential target antigen for immune therapy expressed in a subset of patients with multiple myeloma. We generated chimeric antigen receptors (CARs) recognizing the immunodominant NY-ESO-1 peptide 157-165 in the context of HLA-A*02:01 to re-direct autologous CD8(+) T cells towards NY-ESO-1(+) myeloma cells. These re-directed T cells specifically lysed NY-ESO-1(157-165)/HLA-A*02:01-positive cells and secreted IFNγ. A total of 40% of CCR7(-) re-directed T cells had an effector memory phenotype and 5% a central memory phenotype. Based on CCR7 cell sorting, effector and memory CAR-positive T cells were separated and CCR7(+) memory cells demonstrated after antigen-specific re-stimulation downregulation of CCR7 as sign of differentiation towards effector cells accompanied by an increased secretion of memory signature cytokines such as IL-2. To evaluate NY-ESO-1 as potential target antigen, we screened 78 bone marrow biopsies of multiple myeloma patients where NY-ESO-1 protein was found to be expressed by immunohistochemistry in 9.7% of samples. Adoptively transferred NY-ESO-1-specific re-directed T cells protected mice against challenge with endogenously NY-ESO-1-positive myeloma cells in a xenograft model. In conclusion, re-directed effector- and central memory T cells specifically recognized NY-ESO-1(157-165)/ HLA-A*02:01-positive cells resulting in antigen-specific functionality in vitro and in vivo.

  20. Distinct expression patterns of the immunogenic differentiation antigen NY-BR-1 in normal breast, testis and their malignant counterparts.

    Science.gov (United States)

    Theurillat, Jean-Philippe; Zürrer-Härdi, Ursina; Varga, Zsuzsanna; Barghorn, André; Saller, Elisabeth; Frei, Claudia; Storz, Martina; Behnke, Silvia; Seifert, Burkhardt; Fehr, Mathias; Fink, Daniel; Rageth, Christoph; Linsenmeier, Claudia; Pestalozzi, Bernhard; Chen, Yao-Tseng; Knuth, Alexander; Jäger, Dirk; Moch, Holger

    2008-04-01

    NY-BR-1 is a differentiation antigen and a potential target for cancer immunotherapy. Its mRNA expression is restricted to breast, testis, prostate and breast cancer by RT-PCR. In this study, we correlated NY-BR-1 protein and mRNA expression on tissue microarrays of mammary, prostatic and testicular malignancies using immunohistochemistry and in situ hybridization with probes for exon 4-7 and 30-33. NY-BR-1 mRNA was confined to primary spermatocytes, suggesting a role in spermatogenesis. Exon 4-7 and 30-33 were equally expressed this cell type. However, NY-BR-1 was absent in all germ cell tumours analyzed (n = 475) and present in one of 56 (2%) prostate carcinomas. In breast, NY-BR-1 mRNA expression was detected in 307 of 442 (70%) primary carcinomas, with strong correlation to its protein expression (p < 0.0001). mRNA expression was significantly stronger and more frequently detected by the exon 30-33 probe than by the exon 4-7 probe (70% vs. 35%, p < 0.0001), indicating the presence of alternative splice variants that lack 5-prime sequences. A similar restricted mRNA pattern was also observed in the normal breast epithelium. NY-BR-1 protein and mRNA correlated significantly with estrogen receptor alpha (ER alpha) protein expression (p < 0.0001), with stronger association to NY-BR-1 mRNA than protein (odds ratio 7.7 compared to 4.6). We identified 4 estrogen response elements (ERE)-like sequences nearby the promoter region, suggesting that NY-BR-1 transcription might be controlled by ER alpha. Accordingly, analysis of matching pairs of primary tumors with their recurrences showed a marked decrease of NY-BR-1 expression in recurrences after tamoxifen treatment (p < 0.0001).

  1. MAGE-A3/4 and NY-ESO-1 antigens expression in metastatic esophageal squamous cell carcinoma.

    Science.gov (United States)

    Bujas, T; Marusic, Z; Peric Balja, M; Mijic, A; Kruslin, B; Tomas, D

    2011-03-21

    In the present study we analyzed immunohistochemical expression of MAGE-A 3/4 and NY-ESO-1 in 55 samples of esophageal squamous cell carcinomas (ESCC) and their respective lymph node metastases. To our knowledge this is the first study to assess and compare the expression of these antigens in ESCC lymph node metastases. Fifty (90.9%) primary ESCC were positive for MAGE-A 3/4 and 53 (96.6%) were positive for NY-ESO-1. MAGE-A 3/4 was expressed in all lymph node metastases and the intensity of expression was high in a majority of cases. NY-ESO-1 was negative in 2 (7.1%) lymph nodes metastases, while the reaction was predominantly moderate in the positive group. In primary tumors MAGE-A 3/4 showed a significantly higher intensity of expression compared to NY-ESO-1 (P=0.047), while in lymph node metastases the intensity of expression was not significantly different (P=0.387). Primary tumors with and without lymph node metastases showed no significant differences in MAGE-A 3/4 (P=0.672) and NY-ESO-1 (P=0.444) expression. Intensity of MAGE-A 3/4 (P=0.461) and NY-ESO-1 (P=0.414) expression in primary tumors was not significantly different compared to the expression in their respective lymph nodes metastases. Expression of MAGE-A 3/4 in primary tumors showed significant positive correlation with primary tumor expression of NY-ESO-1 (P=0.021) but no significant correlation with the expression of MAGE-A 3/4 in lymph node metastases (P=0.056). Expression of NY-ESO-1 in primary tumors showed significant positive correlation with the expression of NY-ESO-1 in lymph node metastases (P=0.001) and significant negative correlation with patients’ age (P<0.001). Expression of MAGE-A 3/4 and NY-ESO-1 in primary tumors and lymph node metastases showed no significant correlation with prognostic parameters such as tumor grade and TNM stage (P>0.05). We have shown different levels of MAGE-A 3/4 and NY-ESO-1 expression in almost all specimens of primary tumor and lymph node metastases

  2. A review: dietary restrictions on hunter-gatherer women and the implications for fertility and infant mortality.

    Science.gov (United States)

    Spielmann, K A

    1989-09-01

    In many hunter gatherer societies, food taboos dictate the diets of females. These taboos often happen during their most critical reproductive times in their life, e.g., pregnancy. Among some subarctic Athapaskan societies, females at menarche cannot eat fresh meat. They, like other hunter gatherer societies, also restrict fresh meat consumption for menstruating women. Young women of the Aranda society in Australia cannot eat protein rich foods, e.g., lizards, until they have a child. Australian aboriginal societies restrict protein and fat foods for pregnant and lactating women. Even though the literature shows that the undernourished are inclined to reach menarche at a later age than those who eat a well balanced diet, it does not clearly establish whether differences in age at menarche significantly affect overall fertility. Research done on many different under or marginally nourished populations indicates that maternal nutritional health influences birth spacing significantly. Specifically, undernutrition causes longer postpartum amenorrhea. Therefore, lower fertility rates follow longer birth intervals. Research shows that poor maternal nutritional health does not prevent the fetus from surviving and growing. Yet mothers who do not consume many calories often have low birth weight infants. These infants are at high risk of dying because they have little to no fat reserves and they consume inadequate amounts of nutrition since the mothers cannot make insufficient amounts of milk. Since contemporary research shows that maternal nutritional health does effect fertility and infant mortality, food taboos do have the ability to influence population size. More research is needed to understand the factors that influenced the reproductive rates of past hunter-gatherer societies, so anthropologists can identify the demographically significant changes which sedentism and agriculture caused 10,000 years ago.

  3. Estimation of the tourism climate in the Hunter Region, Australia, in the early twenty-first century

    Science.gov (United States)

    Shiue, Ivy; Matzarakis, Andreas

    2011-07-01

    Existing tourism-related climate information and evaluation are typically based on mean monthly conditions of air temperature and precipitation and do not include thermal perception and other climate parameters relevant for tourists. Here, we quantify climate based on the climate facets relevant to tourism (thermal, physical, aesthetical), and apply the results to the Climate-Tourism-Information-Scheme (CTIS). This paper presents bioclimatic and tourism climatological conditions in the Hunter Region—one of Australia's most popular tourist destinations. In the Hunter Region, generally, temperatures below 15°C occur from April through October, temperatures less than 25°C are expected throughout the whole year, while humidity sits around 50%. As expected, large differences between air temperature and physiologically equivalent temperature (PET) were clearly identified. The widest differences were seen in summer time rather than in the winter period. In addition, cold stress was observed less than 10% of the time in winter while around 40-60% of heat stress was observed in summer time. This correlates with the highest numbers of international visitors, who usually seek a warmer weather, at the beginning of summer time (November and December) and also to the number of domestic visitors, who tend to seek cooler places for recreation and leisure, in late summer (January-March). It was concluded that thermal bioclimate assessment such as PET and CTIS can be applied in the Hunter region, and that local governments and the tourism industry should take an integrated approach to providing more relevant weather and climate information for both domestic and international tourists in the near future.

  4. Groundwater modeling to evaluate interaquifer leakage in the Floridan aquifer system near Hunter Army Airfield and Fort Stewart

    Science.gov (United States)

    Cherry, Gregory S.

    2011-01-01

    Simulations using a modified regional groundwater- flow model were used to determine the amount of leakage from the Upper Floridan aquifer (UFA) through the Lower Floridan confining unit (LFC) into the Lower Floridan aquifer (LFA) resulting from pumping about 1 million gallons per day at newly constructed LFA production wells at Hunter Army Airfield and Fort Stewart in coastal Georgia. Simulated steadystate drawdown at each of the LFA production wells closely matched observed drawdown during a 72-hour aquifer test with the observed water levels reaching steady-state by the end of the test period. However, simulated drawdown was greater than observed drawdown in the UFA because of the short duration of the aquifer test and the time required for groundwater movement through the LFC into the LFA. Steadystate simulations provide an estimate of leakage based on the long-term continuous operation of each production well. Results of model simulations indicate that interaquifer leakage accounts for 48 percent of the flow to the well at Hunter Army Airfield, and 98 percent of the flow to the well at Fort Stewart. Simulated results near the Hunter Army Airfield production well indicated that 65 percent of the leakage from the UFA to the LFA occurs within a 1-mile radius, whereas simulated results near the Fort Stewart production well indicated 80-percent leakage from the UFA to the LFA within the same radius. The greater amount of leakage to the production well near Fort Stewart can be attributed to the higher transmissivity of the UFA and higher vertical hydraulic conductivity in the LFC near the well.

  5. The formation of fire residues associated with hunter-gatherers in humid tropical environments: A geo-ethnoarchaeological perspective

    Science.gov (United States)

    Friesem, David E.; Lavi, Noa; Madella, Marco; Boaretto, Elisabetta; Ajithparsad, P.; French, Charles

    2017-09-01

    Tropical forests have been an important human habitat and played a significant role in early human dispersal and evolution. Likewise, the use of fire, besides being one of the exceptional characteristics of humans, serves as a marker for human evolution. While the use of fire by prehistoric hunter-gatherers is relatively well documented in arid and temperate environments, the archaeological evidence in humid tropical environment is to date very limited. We first review the archaeological evidence for hunter-gatherer use of fire in humid tropical environments and suggest that better understanding of formation processes is required. We present a geo-ethnoarchaeological study from South India, involving ethnography, excavations and laboratory-based analyses in order to build a new framework to study fire residues in humid tropical forests associated with hunter-gatherer's use of fire. Ethnographic observations point to a dynamic and ephemeral use of hearths. Hearths location were dictated by the social and ever-changing social dynamics of the site. The hearths deposited small amount of residues which were later swept on a daily basis, re-depositing ash and charcoal in waste areas and leaving only a microscopic signal in the original location. Particular acidic conditions and intensive biological activity within tropical sediments result in the complete dissolution of ash and bones while favouring the preservation of charcoal and phytoliths. Consequently, the identification of fire residues in humid tropical forests and the reconstruction of the human use of fire must involve multi-proxy microscopic analysis to detect its micro-signatures.

  6. The Bayview Hunters Point Foundation for Community Improvement: a pioneering multi-ethnic human service organization (1971-2008).

    Science.gov (United States)

    Joe, Ellen; Schwartz, Sara L; Austin, Michael J

    2011-01-01

    The Bayview Hunters Point Foundation for Community Improvement is a nonprofit organization established in 1971 to defend the legal rights of African-Americans living in its community. Over the years, the agency diversified its services to include mental health and substance abuse treatment, violence prevention, youth programming, and HIV services. The organization has overcome multiple challenges during its 37-year history in relation to social, political, and economic changes that have influenced the way the organization has financed and delivered its services. The history of the organization presents a collaborative approach to community problem-solving and exemplifies the important role that external relationships play in relationship to nonprofit growth and survival.

  7. Functional responses of human hunters to their prey - why harvest statistics may not always reflect changes in prey population abundance

    DEFF Research Database (Denmark)

    Kahlert, Johnny Abildgaard; Fox, Anthony David; Heldbjerg, Henning

    functional response to the point count indices, with similar auto-correlative structures in the two variables. Other species showed different functional responses, the result of hunter behaviour, such as voluntary hunting restraint on species of concern and saturation effects from rapidly expanding abundant...... are used as an index for population size. It is essential that detectability/accessibility of a species does not change systematically over time. Such bias may derive from habitat shifts, difference in timing of counts and hunting harvest, changes in migration patterns and annual reproduction and mortality...

  8. Plan de mejoramiento para la gestión del direccionamiento estratégico en Market Hunters Ltda

    OpenAIRE

    2012-01-01

    Para el presente proyecto de grado, se realizó un análisis situacional de Market Hunters Ltda, empresa dedicada a la comercialización de aceites y aditivo que a su vez presta servicios de asistencia automotriz. Basado en el ambiente percibido en el técnicentro, la entrevista con el gerente y los resultados encontrados en la matriz integral, se llego a concluir que dicha información representaría para dicha investigación un punto de partida en la búsqueda de la raíz del problema; las falencias...

  9. OPERATION ODESSA: THE FLIGHT OF NAZI WAR CRIMINALS TO LATIN AMERICA AFTER WORLD WAR II AND THE NAZI HUNTERS

    Directory of Open Access Journals (Sweden)

    Marcos Eduardo Meinerz

    2013-06-01

    Full Text Available This article aims to analyze why Latin America, especially Argentina, was the region of the world that harbored the most Nazi war criminals—for example, Josef Mengele, Adolf Eichmann and Klaus Barbie—after World War II. It also aims to analyze how this fact has set the tone for the appearance of literary works about the fantastic adventures of “Nazi hunters” seeking the whereabouts of those individuals. For this purpose, in the first part of the article we will address Nazis’ escape to Latin America. Next, we analyze some literary works by authors who called themselves Nazi hunters.

  10. Hunter color dimensions, sugar content and volatile compounds in pasteurized yellow passion fruit juice (Passiflora edulis var. flavicarpa during storage

    Directory of Open Access Journals (Sweden)

    Delcio Sandi

    2004-06-01

    Full Text Available Changes in Hunter L, a and b values, glucose, fructose and sucrose contents, concentration of four volatile compounds (ethyl butirate, ethyl caproate, hexyl butirate and hexyl caproate and furfural, were studied in yellow passion fruit juice (Passiflora edulis var. flavicarpa pasteurized at 75ºC/60s, 80ºC/41s or 85ºC/27s, during storage at room temperature (25±5ºC and refrigeration (5±1ºC for 120 days. While the sucrose content decreased, the glucose and fructose contents increased significantly over storage time. The Hunter L and b values behaved similarly, with a tendency to decrease over time, inversely to Hunter a value. Volatile compound concentrations also decreased over time, inversely to the furfural content. Pasteurization at 85ºC/27s resulted minimum changes in the studied passion fruit characteristics, while that at 75ºC/60s was the most harmful. Storage under refrigeration tended to keep the best quality characteristics of the juice.Foi estudada a variação dos valores "L", "a" e "b" do sistema de Hunter, dos teores de glucose, frutose e sacarose, e da concentração de quatro compostos voláteis (butirato de etila, caproato de etila, butirato de hexila e caproato de hexila e furfural, em suco de maracujá-amarelo (Passiflora edulis var. flavicarpa submetido à pasteurização (75ºC/60 s, 80ºC/41 s e 85ºC/27 s, durante o armazenamento a temperatura ambiente (25±5ºC e refrigerada (5±1ºC por 120 dias. Enquanto os teores de sacarose diminuíram, aqueles de glucose e frutose aumentaram significativamente. Os valores "L" e "b" apresentaram comportamento semelhante, com tendência a diminuir ao longo do tempo, inversamente ao valor "a". As concentrações dos compostos voláteis também diminuíram, exceto para o furfural. A pasteurização a 85ºC/27 s proporcionou as menores alterações nas características estudadas, enquanto aquela à 75ºC/60 s foi a mais prejudicial. O armazenamento sob refrigeração apresentou

  11. Expression and clinical significance of NY-ESO-1 protein in human laryngeal squamous carcinoma%NY-ESO-1蛋白在喉鳞状细胞癌中表达的意义

    Institute of Scientific and Technical Information of China (English)

    田俊; 王斌全; 李建民; 皇甫辉; 温树信; 张艳廷

    2010-01-01

    目的 检测NY-ESO-1蛋白在喉鳞癌中的表达情况,探讨其作为喉癌免疫治疗靶标的实验依据及其与喉癌生物学行为的关系.方法 免疫组织化学PV-9000两步法检测69例喉鳞癌患者原发灶及其常规病理报告为阳性的121个颈淋巴结中NY-ESO-1的表达,同时采用Western blotting方法检测其在喉鳞癌标本的癌中心区、癌周0.5、1.0 cm及9例全喉切除术患者的喉正常黏膜组织(对照)中的表达.结果 69例喉鳞癌组织中,NY-ESO-1蛋白表达阳性率为43.48%(30/69),在癌中心区、癌周0.5、1.0cm中的表达逐渐下降(P<0.05),NY-ESO-1在对照组喉正常黏膜组织中无表达.NY-ESO-1蛋白在不同T分级、病理分级和不同颈淋巴结转移喉癌中的表达率差异无统计学意义(P>0.05),颈转移淋巴结中NY-ESO-1的表达下调.结论 NY-ESO-1在喉鳞癌患者中特异性高表达,可能以某种方式参与了喉癌的发生、发展,是否能将其作为喉癌免疫治疗靶标有待深入研究.%Objective To detect the expression of Cancer-Testis antigen NY-ESO-1 in human laryngeal squamous carcinoma (LSC) and to explore its significance in immunotherapeutic application. Methods The expressions of NY-ESO-1 protein in the LSC and in the pathologically positive lymph nodes were detected by PV-9000 Immunohistochemistry. Western blotting was also employed to measure the expressions of NY-ESO-1 in the tumor core region(TC), the tissues at the sites of 0.5cm, 1.0cm away from LSC periphery and the distant normal larynx tissues. Results NY-ESO-1 protein expression was positive in 30 out of 69 (43.48 %) cases of LSC. The expression level of NY-ESO-1 protein were found to significantly decrease by tums in TC and corresponding adjacent tissues (P <0.01). None of the nine normal larynx tissues expressed NY-ESO-1 protein.It did not display an obvious correlation between the expression of NY-ESO-1 with T staging, pathological grading and lymph node metastasis (P

  12. NY-ESO-1 Protein Cancer Vaccine With Poly-ICLC and OK-432: Rapid and Strong Induction of NY-ESO-1-specific Immune Responses by Poly-ICLC.

    Science.gov (United States)

    Takeoka, Tomohira; Nagase, Hirotsugu; Kurose, Koji; Ohue, Yoshihiro; Yamasaki, Makoto; Takiguchi, Shuji; Sato, Eiichi; Isobe, Midori; Kanazawa, Takayuki; Matsumoto, Mitsunobu; Iwahori, Kota; Kawashima, Atsunari; Morimoto-Okazawa, Akiko; Nishikawa, Hiroyoshi; Oka, Mikio; Pan, Linda; Venhaus, Ralph; Nakayama, Eiichi; Mori, Masaki; Doki, Yuichiro; Wada, Hisashi

    2017-03-23

    We conducted a clinical trial of a cancer vaccine using NY-ESO-1 protein with polyinosinic-polycytidylic acid-poly-L-lysine carboxymethylcellulose (poly-ICLC) and/or OK-432 against solid tumors. A total of 15 patients were sequentially enrolled in 4 cohorts. Patients in cohort 1 received NY-ESO-1 protein; cohort 2a received NY-ESO-1 protein+OK-432; cohort 2b received NY-ESO-1 protein+poly-ICLC; cohort 3 received NY-ESO-1 protein+OK-432+poly-ICLC with Montanide ISA-51. The endpoints of this trial were safety, NY-ESO-1 immune responses, and clinical response. Vaccine-related adverse events observed were fever and injection-site reaction (grade 1). Two patients showed stable disease after vaccination. NY-ESO-1 antibodies were observed in 4 patients at the baseline (sero-positive) and augmented in all patients after vaccination. Eleven patients showed a conversion of negative antibody responses at baseline to positive after vaccination (seroconversion). The seroconversions were observed in all 11 sero-negative patients by the fourth immunization; in particular, it was observed by the second immunization in patients with poly-ICLC, and these induced antibody responses were stronger than those in patients immunized without poly-ICLC. The number of NY-ESO-1-specific interferon (IFN)γ-producing T cells was increased in patients immunized with poly-ICLC and/or OK-432, and furthermore, the increase of IFNγ-producing CD8 T cells in patients immunized with poly-ICLC was significantly higher than that in patients without poly-ICLC. Nonspecific activations of T-cell or antigen presenting cells were not observed. Our present study showed that poly-ICLC is a promising adjuvant for cancer vaccines.

  13. Molecular cloning, prokaryotic expression and purification of human CT antigen NY-ESO-1%CT抗原NY-ESO-1基因克隆、表达及纯化

    Institute of Scientific and Technical Information of China (English)

    江华; 郑玉玲; 姜永强

    2007-01-01

    目的:利用大肠杆菌表达人CT抗原NY-ESO-1,对表达产物进行Western印迹鉴定和纯化,为今后利用其进行肿瘤疫苗的研究奠定基础.方法:通过全基因拼接获得NY-ESO-1基因,构建重组表达载体NY-ESO-1-pET28a(+),在大肠杆菌BL21(DE3)中利用IPTG诱导获得表达,利用单克隆抗体进行Western印迹鉴定,通过Ni柱亲和纯化获得纯化蛋白.结果与结论:拼接的NY-ESO-1全基因经测序证明与GenBank中人的NY-ESO-l全基因完全相符;构建的原核表达载体NY-ESO-1-pET28a(+)可稳定地可溶性表达NY-ESO-1蛋白;经Ni柱亲和纯化获得较好的纯化结果;利用鼠抗人单克隆抗体对表达的蛋白进行验证,结果显示阳性.本研究成功利用原核表达系统实现了对CT抗原NY-ESO-1的可溶性表达.

  14. Chemical and geochemical composition of spring-summer Arctic aerosol collected at Ny Alesund, Svalbard Islands.

    Science.gov (United States)

    Udisti, Roberto; Becagli, Silvia; Caiazzo, Laura; Cappelletti, David; Giardi, Fabio; Grotti, Marco; Lucarelli, Franco; Moroni, Beatrice; Nava, Silvia; Severi, Mirko; Traversi, Rita

    2017-04-01

    Since March 2010, spring-summer (usually March - September) campaigns were continuously carried out at the Italian Gruvebadet Observatory, Ny Alesund, Svalbard Island. Aerosol was sampled by PM10 (daily) and 4-stage (4-day resolution) collector devices and size distribution was evaluated at 10 min resolution in the range 10 nm - 20 um (106 size classes by a TSI SMPS-APS integrated system). Six-year (2010-2015) PM10 and size-segregated (>10, 10-2.5, 2.5-1, 10.1016/j.atmosenv.2016.04.002. A. Bazzano et al., "Long-range transport of atmospheric lead reaching Ny Alesund: inter-annual and seasonal variations of potential source areas". Atmos. Environ., 2016, 139, 11-19. http://dx.doi.org/10.1016/j.atmosenv.2016.05.026.

  15. Ny krigsførelse i informationsalderen? Om ‘Revolution in Military Affairs’ og Irakkrigen

    Directory of Open Access Journals (Sweden)

    Jens Claus Hansen

    2005-09-01

    Full Text Available Artiklen diskuterer, hvorvidt man efter Golfkrigen kan tale om en ‘Revolu- tion in Military Affairs’ – RMA – som nogle amerikanske krigsteoretikere hævder har fundet sted med anvendelsen af ny teknologi i moderne krigs- førelse. Forfatteren viser, hvordan moderne krigsstrategier har inkorpore- ret ny teknologi og mediebrug som bl.a. informationskrig, ‘Systems of Sys- tems’ og Network Centric Warfare. Forfatteren påpeger, at den strategiske anvendelse af informationsoperationer – herunder ‘embedded’ journalister – ikke har medført en demokratisering af nyhedsdækningen og heller ikke indebærer en øget sandhedsværdi. Afslutningsvis peger forfatteren på behovet for en ‘Revolution in Diplomatic Affairs’.

  16. Characteristics of carbonaceous aerosol in a two-week campaign at Ny-(A)lesund

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The concentrations of organic carbon (OC) and elemental carbon (EC)in total suspended particle (TSP) were investigated at Ny-(A)lesund, Svalbard in a two-week campaign. The levels of OC and EC are 0.86 ±0.27 μgm-3 (mean±standard deviation) and 0. 19±0.10 μgm-3 , respectively. Back trajectory analysis of air masses arriving at Ny-(A)lesund reveals that long-range transport of polluted air play insignificant role in OC and EC levels, to which the potential influence of the local contamination were ascribed. The average OC/EC ratio is 5.41,suggesting the presence of the secondary organic aerosols. The estimated secondary organic carbon (SOC) in TSP is 0.59 μg/m3 , accounting for 64% of the total organic carbon.

  17. Hunters of the Ice Age: The biology of Upper Paleolithic people.

    Science.gov (United States)

    Holt, Brigitte M; Formicola, Vincenzo

    2008-01-01

    The Upper Paleolithic represents both the phase during which anatomically modern humans appeared and the climax of hunter-gatherer cultures. Demographic expansion into new areas that took place during this period and the diffusion of burial practices resulted in an unprecedented number of well-preserved human remains. This skeletal record, dovetailed with archeological, environmental, and chronological contexts, allows testing of hypotheses regarding biological processes at the population level. In this article, we review key studies about the biology of Upper Paleolithic populations based primarily on European samples, but integrating information from other areas of the Old World whenever possible. Data about cranial morphology, skeletal robusticity, stature, body proportions, health status, diet, physical activity, and genetics are evaluated in Late Pleistocene climatic and cultural contexts. Various lines of evidence delineate the Last Glacial Maximum (LGM) as a critical phase in the biological and cultural evolution of Upper Paleolithic populations. The LGM, a long phase of climatic deterioration culminating around 20,000 BP, had a profound impact on the environment, lifestyle, and behavior of human groups. Some of these effects are recorded in aspects of skeletal biology of these populations. Groups living before and after the LGM, Early Upper Paleolithic (EUP) and Late Upper Paleolithic (LUP), respectively, differ significantly in craniofacial dimensions, stature, robusticity, and body proportions. While paleopathological and stable isotope data suggest good health status throughout the Upper Paleolithic, some stress indicators point to a slight decline in quality of life in LUP populations. The intriguing and unexpected incidence of individuals affected by congenital disorders probably indicates selective burial practices for these abnormal individuals. While some of the changes observed can be explained through models of biocultural or environmental

  18. Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet.

    Science.gov (United States)

    Frassetto, L A; Schloetter, M; Mietus-Synder, M; Morris, R C; Sebastian, A

    2009-08-01

    The contemporary American diet figures centrally in the pathogenesis of numerous chronic diseases-'diseases of civilization'. We investigated in humans whether a diet similar to that consumed by our preagricultural hunter-gatherer ancestors (that is, a paleolithic type diet) confers health benefits. We performed an outpatient, metabolically controlled study, in nine nonobese sedentary healthy volunteers, ensuring no weight loss by daily weight. We compared the findings when the participants consumed their usual diet with those when they consumed a paleolithic type diet. The participants consumed their usual diet for 3 days, three ramp-up diets of increasing potassium and fiber for 7 days, then a paleolithic type diet comprising lean meat, fruits, vegetables and nuts, and excluding nonpaleolithic type foods, such as cereal grains, dairy or legumes, for 10 days. Outcomes included arterial blood pressure (BP); 24-h urine sodium and potassium excretion; plasma glucose and insulin areas under the curve (AUC) during a 2 h oral glucose tolerance test (OGTT); insulin sensitivity; plasma lipid concentrations; and brachial artery reactivity in response to ischemia. Compared with the baseline (usual) diet, we observed (a) significant reductions in BP associated with improved arterial distensibility (-3.1+/-2.9, P=0.01 and +0.19+/-0.23, P=0.05);(b) significant reduction in plasma insulin vs time AUC, during the OGTT (P=0.006); and (c) large significant reductions in total cholesterol, low-density lipoproteins (LDL) and triglycerides (-0.8+/-0.6 (P=0.007), -0.7+/-0.5 (P=0.003) and -0.3+/-0.3 (P=0.01) mmol/l respectively). In all these measured variables, either eight or all nine participants had identical directional responses when switched to paleolithic type diet, that is, near consistently improved status of circulatory, carbohydrate and lipid metabolism/physiology. Even short-term consumption of a paleolithic type diet improves BP and glucose tolerance, decreases insulin

  19. CIRCUMBINARY PLANETS ORBITING THE RAPIDLY PULSATING SUBDWARF B-TYPE BINARY NY Vir

    Energy Technology Data Exchange (ETDEWEB)

    Qian, S.-B.; Zhu, L.-Y.; Dai, Z.-B.; He, J.-J. [National Astronomical Observatories/Yunnan Observatory, Chinese Academy of Sciences (CAS), P.O. Box 110, 650011 Kunming (China); Fernandez-Lajus, E. [Facultad de Ciencias Astronomicas y Geofisicas, Universidad Nacional de La Plata, 1900 La Plata, Buenos Aires (Argentina); Xiang, F.-Y., E-mail: qsb@ynao.ac.cn [Physics Department, Xiangtan University, 411105 Xiangtan, Funan Province (China)

    2012-02-15

    We report here the tentative discovery of a Jovian planet in orbit around the rapidly pulsating subdwarf B-type (sdB-type) eclipsing binary NY Vir. By using newly determined eclipse times together with those collected from the literature, we detect that the observed-calculated (O - C) curve of NY Vir shows a small-amplitude cyclic variation with a period of 7.9 yr and a semiamplitude of 6.1 s, while it undergoes a downward parabolic change (revealing a period decrease at a rate of P-dot = -9.2 x 10{sup -12}). The periodic variation was analyzed for the light-travel-time effect via the presence of a third body. The mass of the tertiary companion was determined to be M{sub 3}sin i' = 2.3({+-} 0.3)M{sub Jupiter} when a total mass of 0.60 M{sub Sun} for NY Vir is adopted. This suggests that it is most probably a giant circumbinary planet orbiting NY Vir at a distance of about 3.3 astronomical units (AU). Since the rate of period decrease cannot be explained by true angular momentum loss caused by gravitational radiation or/and magnetic braking, the observed downward parabolic change in the O - C diagram may be only a part of a long-period (longer than 15 years) cyclic variation, which may reveal the presence of another Jovian planet ({approx}2.5 M{sub Jupiter}) in the system.

  20. Immunohistochemical assessment of NY-ESO-1 expression in esophageal adenocarcinoma resection specimens.

    Science.gov (United States)

    Hayes, Stephen J; Hng, Keng Ngee; Clark, Peter; Thistlethwaite, Fiona; Hawkins, Robert E; Ang, Yeng

    2014-04-14

    To assess NY-ESO-1 expression in a cohort of esophageal adenocarcinomas. A retrospective search of our tissue archive for esophageal resection specimens containing esophageal adenocarcinoma was performed, for cases which had previously been reported for diagnostic purposes, using the systematised nomenclature of human and veterinary medicine coding system. Original haematoxylin and eosin stained sections were reviewed, using light microscopy, to confirm classification and tumour differentiation. A total of 27 adenocarcinoma resection specimens were then assessed using immunohistochemistry for NY-ESO-1 expression: 4 well differentiated, 14 moderately differentiated, 4 moderate-poorly differentiated, and 5 poorly differentiated. Four out of a total of 27 cases of esophageal adenocarcinoma examined (15%) displayed diffuse cytoplasmic and nuclear expression for NY-ESO-1. They displayed a heterogeneous and mosaic-type pattern of diffuse staining. Diffuse cytoplasmic staining was not identified in any of these structures: stroma, normal squamous epithelium, normal submucosal gland and duct, Barrett's esophagus (goblet cell), Barrett's esophagus (non-goblet cell) and high grade glandular dysplasia. All adenocarcinomas showed an unexpected dot-type pattern of staining at nuclear, paranuclear and cytoplasmic locations. Similar dot-type staining, with varying frequency and size of dots, was observed on examination of Barrett's metaplasia, esophageal submucosal gland acini and the large bowel negative control, predominantly at the crypt base. Furthermore, a prominent pattern of apical (luminal) cytoplasmic dot-type staining was observed in some cases of Barrett's metaplasia and also adenocarcinoma. A further morphological finding of interest was noted on examination of haematoxylin and eosin stained sections, as aggregates of lymphocytes were consistently noted to surround submucosal glands. We have demonstrated for the first time NY-ESO-1 expression by esophageal

  1. Designprocesser og arbejdsmiljø: Udvikling af ny teknologi til fødevareindustrien

    DEFF Research Database (Denmark)

    Broberg, Ole

    1999-01-01

    Dette papir handler om muligheder og betingelser for at inddrage arbejdsmiljøhensyn i designprocesser. Baggrunden for det er, at jeg har haft mulighed for at følge udviklingen af en ny maskine til fødevareindustrien næsten lige fra de grundlæggende idéer blev udviklet og foreløbig frem til i dag,...

  2. A novel murine T-cell receptor targeting NY-ESO-1.

    Science.gov (United States)

    Rosati, Shannon F; Parkhurst, Maria R; Hong, Young; Zheng, Zhili; Feldman, Steven A; Rao, Mahadev; Abate-Daga, Daniel; Beard, Rachel E; Xu, Hui; Black, Mary A; Robbins, Paul F; Schrump, David A; Rosenberg, Steven A; Morgan, Richard A

    2014-04-01

    Cancer testis antigens, such as NY-ESO-1, are expressed in a variety of prevalent tumors and represent potential targets for T-cell receptor (TCR) gene therapy. DNA encoding a murine anti-NY-ESO-1 TCR gene (mTCR) was isolated from immunized HLA-A*0201 transgenic mice and inserted into a γ-retroviral vector. Two mTCR vectors were produced and used to transduce human PBL. Transduced cells were cocultured with tumor target cell lines and T2 cells pulsed with the NY-ESO-1 peptide, and assayed for cytokine release and cell lysis activity. The most active TCR construct was selected for production of a master cell bank for clinical use. mTCR-transduced PBL maintained TCR expression in short-term and long-term culture, ranging from 50% to 90% efficiency 7-11 days after stimulation and 46%-82% 10-20 days after restimulation. High levels of interferon-γ secretion were observed (1000-12000 pg/mL), in tumor coculture assays and recognition of peptide-pulsed cells was observed at 0.1 ng/mL, suggesting that the new mTCR had high avidity for antigen recognition. mTCR-transduced T cells also specifically lysed human tumor targets. In all assays, the mTCR was equivalent or better than the comparable human TCR. As the functional activity of TCR-transduced cells may be affected by the formation of mixed dimers, mTCRs, which are less likely to form mixed dimers with endogenous hTCRs, may be more effective in vivo. This new mTCR targeted to NY-ESO-1 represents a novel potential therapeutic option for adoptive cell-transfer therapy for a variety of malignancies.

  3. Formulation of Organic Fertilizer Standard in Jiaxing City Based on NY525-2012

    Institute of Scientific and Technical Information of China (English)

    Jinfa; HUANG; Xiongwei; NI; Jianping; XIE; Yanping; SHI

    2013-01-01

    On the basis of research, analysis and argumentation, we conduct analysis and research on the current situation of quality of commercial organic fertilizer in Jiaxing City, and carry out the inspection and testing of organic matter indicators using the laboratory. Based on the standard of NY525-2012 Organic Fertilizer by the Ministry of Agriculture, this paper formulates the quality level indicators of local commercial organic fertilizer and adding specifications of raw materials.

  4. Archive of Datasonics SIS-1000 Boomer Subbottom Data Collected During USGS Cruise DIAN 97011 Long Island, NY Inner Shelf

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This CD-ROM contains digital high resolution seismic reflection data collected during the USGS DIAN 97011 cruise. The coverage is the nearshore of Long Island, NY in...

  5. Archive of Datasonics SIS-1000 Boomer Subbottom Data Collected During USGS Cruise DIAN 97011 Long Island, NY Inner Shelf

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This CD-ROM contains digital high resolution seismic reflection data collected during the USGS DIAN 97011 cruise. The coverage is the nearshore of Long Island, NY in...

  6. Archive of Datasonics SIS-1000 Boomer Subbottom Data Collected During USGS Cruise DIAN 97011 Long Island, NY Inner Shelf

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This CD-ROM contains digital high resolution seismic reflection data collected during the USGS DIAN 97011 cruise. The coverage is the nearshore of Long Island, NY...

  7. Kate Bárány: a life of science, teaching, and service.

    Science.gov (United States)

    Solaro, R John; Rao, Mrinalini C

    2012-12-01

    We celebrate the lives of Michael and Kate Bárány in this issue of the Journal of Muscle Research and Cell Motility. Kate and Michael died within weeks of each other in 2011. Joe Chalovich has written about Michael and we write about Kate. As emphasized by Joe, Kate, and Michael were remarkable individuals who survived the Holocaust, the Hungarian revolution, and emerged from as much adversity as one might imagine to become productive scientists, educators, citizens, and symbols of the durability of the human spirit. They present their own story in an essay (Bárány and Bárány 2000) published in a monograph "Selected Topics in the History of Biochemistry." Rather than repeating much of the list of scientific achievements chronicled in these papers, we focus here on Kate, especially in her role as an individual and partner in science, while at the same time being an accomplished teacher, and a champion of women in science.

  8. Prompt Gamma Activation Analysis of the Nyírlugos obsidian core depot find

    Directory of Open Access Journals (Sweden)

    Zsolt Kasztovszky

    2014-03-01

    Full Text Available The Nyírlugos obsidian core depot find is one of the most important lithic assemblages in the collection of the Hungarian National Museum (HNM. The original set comprised 12 giant obsidian cores, of which 11 are currently on the permanent archaeological exhibition of the HNM. One of the cores is known to be inDebrecen. The first publication attributed the hoard, on the strength of giant (flint blades known from the Early and Middle Copper Age Tiszapolgár and Bodrogkeresztúr cultures, to the Copper Age. In the light of recent finds it is more likely to belong to the Middle Neolithic period. The source area was defined as Tokaj Mts., about100 kmto the NW from Nyírlugos. The size and beauty of the exceptional pieces exclude any invasive analysis. Using Prompt Gamma Activation Analysis (PGAA, we can measure major chemical components and some key trace elements of stone artefacts with adequate accuracy to successfully determine provenance of obsidian. Recent methodological development also facilitated the study of relatively large objects like the Nyírlugos cores. The cores were individually measured by PGAA. The results show that the cores originate from the Carpathian 1 sources, most probably the Viničky variety (C1b. The study of the hoard as a batch is an important contribution to the assessment of prehistoric trade and allows us to reconsider the so-called Carpathian, especially Carpathian 1 (Slovakian sources.

  9. Resiquimod as an Immunologic Adjuvant for NY-ESO-1 Protein Vaccination in Patients with High Risk Melanoma

    Science.gov (United States)

    Gnjatic, Sacha; Cruz, Crystal M.; Vengco, Isabelita; Hasan, Farah; Spadaccia, Meredith; Darvishian, Farbod; Chiriboga, Luis; Holman, Rose Marie; Escalon, Juliet; Muren, Caroline; Escano, Crystal; Yepes, Ethel; Sharpe, Dunbar; Vasilakos, John P.; Rolnitzsky, Linda; Goldberg, Judith; Mandeli, John; Adams, Sylvia; Jungbluth, Achim; Pan, Linda; Venhaus, Ralph; Ott, Patrick A.; Bhardwaj, Nina

    2015-01-01

    The TLR7/8 agonist, Resiquimod has been used as an immune adjuvant in cancer vaccines. We evaluated the safety and immunogenicity of the cancer testis antigen NY-ESO-1 given in combination with Montanide with or without Resiquimod in high-risk melanoma patients. In Part I of the study, patients received 100ug full length NY-ESO-1 protein emulsified in 1.25mL Montanide (day 1) followed by topical application of 1000mg of 0.2% Resiquimod gel on days 1 and 3 (Cohort 1) versus days 1, 3, and 5 (Cohort 2) of a 21 day cycle. In Part II, patients were randomized to receive 100ug NY-ESO-1 protein plus Montanide (day 1) followed by topical application of placebo gel (Arm-A; N=8) or 1000mg of 0.2% Resiquimod gel (Arm-B; N=12) using the dosing regimen established in Part I. The vaccine regimens were generally well-tolerated. NY-ESO-1-specific humoral responses were induced or boosted in all patients, many of whom had high titer antibodies. In Part II, 16 of 20 patients in both arms had NY-ESO-1-specific CD4+ T-cell responses. CD8+ T-cell responses were only seen in 3 of 12 patients in Arm B. Patients with TLR7 SNP rs179008 had a greater likelihood of developing NY-ESO-1-specific CD8+ responses. In conclusion, NY-ESO-1 protein in combination with Montanide with or without topical Resiquimod is safe and induces both antibody and CD4+ T-cell responses in the majority of patients; the small proportion of CD8+ T-cell responses suggests that the addition of topical Resiquimod to Montanide is not sufficient to induce consistent NY-ESO-1-specific CD8+ T-cell responses. PMID:25633712

  10. NY-ESO-1在喉鳞状细胞癌中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    周慧; 凌红阳; 吴文璎; 郑玉双

    2015-01-01

    目的 探讨喉鳞状细胞癌组织中NY-ESO-1蛋白表达及其临床意义.方法 免疫组化方法检测88例喉鳞状细胞癌组织(A组)和10例声带息肉组织(B组)NY-ESO-1蛋白的表达.A组再分为四个亚组,临床分期Ⅰ、Ⅱ期38例(A1组),临床分期Ⅲ、Ⅳ期50例(A2组);病理类型高、中分化60例(A3组),低分化28例(A4组).结果 A组NY-ESO-1蛋白表达水平高于B组(4598±2302 vs.0)(P<0.01).A1组NY-ESO-1表达水平高于A2组(8052±3810 vs.162±107)(P<0.05).A3组NY-ESO-1表达水平高于A4组(5090±1893 vs.211±201) (P<0.05).结论 NY-ESO-1有可能作为喉鳞癌早期诊断的新指标;NY-ESO-1表达阳性的高、中分化喉鳞癌患者可能可以选择NY-ESO-1疫苗作为辅助治疗.

  11. Planet Hunters: The First Two Planet Candidates Identified by the Public using the Kepler Public Archive Data

    CERN Document Server

    Fisher, Debra; Schawinski, Kevin; Lintott, Chris; Brewer, John; Giguere, Matt; Lynn, Stuart; Parrish, Michael; Sartori, Thibault; Simpson, Robert; Smith, Arfon; Spronck, Julien; Batalha, Natalie; Rowe, Jason; Jenkins, Jon; Bryson, Steve; Prsa, Andrej; Tenenbaum, Peter; Crepp, Justin; Morton, Tim; Howard, Andrew; Beleu, Michele; Kaplan, Zachary; vanNispen, Nick; Sharzer, Charlie; DeFouw, Justin; Hajduk, Agnieszka; Neal, Joe; Nemec, Adam; Schuepbach, Nadine; Zimmermann, Valerij

    2011-01-01

    Planet Hunters is a new citizen science project, designed to engage the public in an exoplanet search using NASA Kepler public release data. In the first month after launch, users identified two new planet candidates which survived our checks for false- positives. The follow-up effort included analysis of Keck HIRES spectra of the host stars, analysis of pixel centroid offsets in the Kepler data and adaptive optics imaging at Keck using NIRC2. Spectral synthesis modeling coupled with stellar evolutionary models yields a stellar density distribution, which is used to model the transit orbit. The orbital periods of the planet candidates are 9.8844 ±0.0087 days (KIC 10905746) and 49.7696 ±0.00039 (KIC 6185331) days and the modeled planet radii are 2.65 and 8.05 R⊕. The involvement of citizen scientists as part of Planet Hunters is therefore shown to be a valuable and reliable tool in exoplanet detection.

  12. Speculation on the timing and nature of Late Pleistocene hunter-gatherer colonization of the Tibetan Plateau

    Institute of Scientific and Technical Information of China (English)

    P. J. Brantingham; MA Haizhou; J. W. Olsen; GAO Xing; D. B. Madsen; D. E. Rhode

    2003-01-01

    Hunter-gatherer populations in greater northeast Asia experienced dramatic range expansions during the early Upper Paleolithic (45-22 ka) and the late Upper Paleolithic (18-10 ka), both of which led to intensive occupations of cold desert environments including the Mongolian Gobi and northwest China. Range contractions under the cold, arid extremes of the Last Glacial Maximum (LGM, 22-18 ka) may have entailed widespread population extirpations. The high elevation Qinghai-Tibetan Plateau is significantly more extreme in both climate and environment than either the Gobi or the Siberian taiga forests, and provides an ideal setting to test fundamental models of human biogeog-raphy in the context of regional population fluctuations. The area is presently occupied primarily by nomadic pastoralists, but it is clear that these complex middle Holocene (<6 ka) economic adaptations were not a necessary prerequisite for successful colonization of the high elevation Plateau. Exploratory field-work in 2000-2001 has established that Upper Paleolithic hunter-gatherers were present on the Qinghai-Tibetan Plateau by at least 12 ka and possibly much earlier. Aspeculative model for the colonization process is developed and preliminary archaeological data in support of the model are presented.

  13. The issue of socioeconomic complexity in the mesolithic hunter-gatherer communities of the middle and upper Ebro valley

    Directory of Open Access Journals (Sweden)

    García-Martínez de Lagrán, Íñigo

    2008-12-01

    Full Text Available In recent decades several hunter-gatherer groups have been defined, from ethnography and archaeology, as complex socioeconomic communities. This article reviews the main definitions of complexity and its principal feature contrasting them with the archaeological record of the Mesolithic in the Ebro valley. The main goal of this paper is to find out if these hunter-gatherer communities show indications of a certain socioeconomic complexity.

    En las últimas décadas se han definido en el ámbito etnográfico y arqueológico diferentes comunidades de cazadores-recolectores que presentan una organización socioeconómica compleja. En el presente trabajo se hace un repaso a las principales definiciones de esta complejidad y a sus rasgos fundamentales aplicándolos al registro actual del Mesolítico en la Alta y Media Cuenca del Ebro. El objetivo principal es determinar si estas comunidades de cazadores-recolectores presentan rasgos definitorios de una cierta complejidad socioeconómica.

  14. Ethnotaxonomy of mastofauna as practised by hunters of the municipality of Paulista, state of Paraíba-Brazil

    Science.gov (United States)

    Mourão, José S; Araujo, Helder FP; Almeida, Fabiana S

    2006-01-01

    It was aimed in the present work to report aspects related to identification, naming and categorization of the mastofauna species of the caatinga biome, according to hunters' knowledge of Northeast Brazil. The methods of free and semi-structured interviews and guided tours were applied here. The data obtained were analyzed under the emic/etic point of view by comparing the local people's knowledge to those reported in the literature. The inland hunters use some classification models of mammals living around them as for example the folk taxonomy, and a categorization based on the animal utility. Some species are preferably hunted for providing food while others are hunted for therapeutic ends. Hunt techniques were made evident by the informers. The retrieval and comprehension of the whole process related to such knowledge is very important to evaluate the human culture and the protection that people exert on local biodiversity, since these aspects have implications for the conservation and management of faunistic resources. PMID:16603080

  15. Hunter-gatherer adaptations and environmental change in the southern Great Basin: The evidence from Pahute and Rainier mesas

    Energy Technology Data Exchange (ETDEWEB)

    Pippin, L.C.

    1998-06-01

    This paper reviews the evidence for fluctuations in past environments in the southern Great Basin and examines how these changes may have affected the strategies followed by past hunter and gatherers in their utilization of the resources available on a highland in this region. The evidence used to reconstruct past environments for the region include botanical remains from packrat middens, pollen spectra from lake and spring deposits, faunal remains recovered from archaeological and geologic contexts, tree-ring indices from trees located in sensitive (tree-line) environments, and eolian, alluvial and fluvial sediments deposited in a variety of contexts. Interpretations of past hunter and gatherer adaptive strategies are based on a sample of 1,311 archaeological sites recorded during preconstruction surveys on Pahute and Rainier mesas in advance of the US Department of Energy`s nuclear weapons testing program. Projectile point chronologies and available tree-ring, radiocarbon, thermoluminescence and obsidian hydration dates were used to assign these archaeological sites to specific periods of use.

  16. Immune escape from NY-ESO-1-specific T-cell therapy via loss of heterozygosity in the MHC.

    Science.gov (United States)

    Klippel, Z K; Chou, J; Towlerton, A M; Voong, L N; Robbins, P; Bensinger, W I; Warren, E H

    2014-03-01

    Adoptive immunotherapy of tumors with T cells specific for the cancer-testis antigen NY-ESO-1 has shown great promise in preclinical models and in early stage clinical trials. Tumor persistence or recurrence after NY-ESO-1-specific therapy occurs, however, and the mechanisms of recurrence remain poorly defined. In a murine xenograft model of NY-ESO-1(+) multiple myeloma, we observed tumor recurrence after adoptive transfer of CD8(+) T cells genetically redirected to the prototypic NY-ESO-1157-165 peptide presented by HLA-A*02:01. Analysis of the myeloma cells that had escaped from T-cell control revealed intact expression of NY-ESO-1 and B2M, but selective, complete loss of HLA-A*02:01 expression from the cell surface. Loss of heterozygosity (LOH) in the major histocompatibility complex (MHC) involving the HLA-A locus was identified in the tumor cells, and further analysis revealed selective loss of the allele encoding HLA-A*02:01. Although LOH involving the MHC has not been described in myeloma patients with persistent or recurrent disease after immune therapies such as allogeneic hematopoietic cell transplantation (HCT), it has been described in patients with acute myelogenous leukemia who relapsed after allogeneic HCT. These results suggest that MHC loss should be evaluated in patients with myeloma and other cancers who relapse after adoptive NY-ESO-1-specific T-cell therapy.

  17. A cancer vaccine induces expansion of NY-ESO-1-specific regulatory T cells in patients with advanced melanoma.

    Science.gov (United States)

    Ebert, Lisa M; MacRaild, Sarah E; Zanker, Damien; Davis, Ian D; Cebon, Jonathan; Chen, Weisan

    2012-01-01

    Cancer vaccines are designed to expand tumor antigen-specific T cells with effector function. However, they may also inadvertently expand regulatory T cells (Treg), which could seriously hamper clinical efficacy. To address this possibility, we developed a novel assay to detect antigen-specific Treg based on down-regulation of surface CD3 following TCR engagement, and used this approach to screen for Treg specific to the NY-ESO-1 tumor antigen in melanoma patients treated with the NY-ESO-1/ISCOMATRIX™ cancer vaccine. All patients tested had Treg (CD25(bright) FoxP3(+) CD127(neg)) specific for at least one NY-ESO-1 epitope in the blood. Strikingly, comparison with pre-treatment samples revealed that many of these responses were induced or boosted by vaccination. The most frequently detected response was toward the HLA-DP4-restricted NY-ESO-1(157-170) epitope, which is also recognized by effector T cells. Notably, functional Treg specific for an HLA-DR-restricted epitope within the NY-ESO-1(115-132) peptide were also identified at high frequency in tumor tissue, suggesting that NY-ESO-1-specific Treg may suppress local anti-tumor immune responses. Together, our data provide compelling evidence for the ability of a cancer vaccine to expand tumor antigen-specific Treg in the setting of advanced cancer, a finding which should be given serious consideration in the design of future cancer vaccine clinical trials.

  18. Tetramer guided, cell sorter assisted production of clinical grade autologous NY-ESO-1 specific CD8(+) T cells.

    Science.gov (United States)

    Pollack, Seth M; Jones, Robin L; Farrar, Erik A; Lai, Ivy P; Lee, Sylvia M; Cao, Jianhong; Pillarisetty, Venu G; Hoch, Benjamin L; Gullett, Ashley; Bleakley, Marie; Conrad, Ernest U; Eary, Janet F; Shibuya, Kendall C; Warren, Edus H; Carstens, Jason N; Heimfeld, Shelly; Riddell, Stanley R; Yee, Cassian

    2014-01-01

    Adoptive T cell therapy represents an attractive modality for the treatment of patients with cancer. Peripheral blood mononuclear cells have been used as a source of antigen specific T cells but the very low frequency of T cells recognizing commonly expressed antigens such as NY-ESO-1 limit the applicability of this approach to other solid tumors. To overcome this, we tested a strategy combining IL-21 modulation during in vitro stimulation with first-in-class use of tetramer-guided cell sorting to generate NY-ESO-1 specific cytotoxic T lymphocytes (CTL). CTL generation was evaluated in 6 patients with NY-ESO-1 positive sarcomas, under clinical manufacturing conditions and characterized for phenotypic and functional properties. Following in vitro stimulation, T cells stained with NY-ESO-1 tetramer were enriched from frequencies as low as 0.4% to >90% after single pass through a clinical grade sorter. NY-ESO-1 specific T cells were generated from all 6 patients. The final products expanded on average 1200-fold to a total of 36 billion cells, were oligoclonal and contained 67-97% CD8(+), tetramer(+) T cells with a memory phenotype that recognized endogenous NY-ESO-1. This study represents the first series using tetramer-guided cell sorting to generate T cells for adoptive therapy. This approach, when used to target more broadly expressed tumor antigens such as WT-1 and additional Cancer-Testis antigens will enhance the scope and feasibility of adoptive T cell therapy.

  19. T346Hunter: a novel web-based tool for the prediction of type III, type IV and type VI secretion systems in bacterial genomes.

    Directory of Open Access Journals (Sweden)

    Pedro Manuel Martínez-García

    Full Text Available T346Hunter (Type Three, Four and Six secretion system Hunter is a web-based tool for the identification and localisation of type III, type IV and type VI secretion systems (T3SS, T4SS and T6SS, respectively clusters in bacterial genomes. Non-flagellar T3SS (NF-T3SS and T6SS are complex molecular machines that deliver effector proteins from bacterial cells into the environment or into other eukaryotic or prokaryotic cells, with significant implications for pathogenesis of the strains encoding them. Meanwhile, T4SS is a more functionally diverse system, which is involved in not only effector translocation but also conjugation and DNA uptake/release. Development of control strategies against bacterial-mediated diseases requires genomic identification of the virulence arsenal of pathogenic bacteria, with T3SS, T4SS and T6SS being major determinants in this regard. Therefore, computational methods for systematic identification of these specialised machines are of particular interest. With the aim of facilitating this task, T346Hunter provides a user-friendly web-based tool for the prediction of T3SS, T4SS and T6SS clusters in newly sequenced bacterial genomes. After inspection of the available scientific literature, we constructed a database of hidden Markov model (HMM protein profiles and sequences representing the various components of T3SS, T4SS and T6SS. T346Hunter performs searches of such a database against user-supplied bacterial sequences and localises enriched regions in any of these three types of secretion systems. Moreover, through the T346Hunter server, users can visualise the predicted clusters obtained for approximately 1700 bacterial chromosomes and plasmids. T346Hunter offers great help to researchers in advancing their understanding of the biological mechanisms in which these sophisticated molecular machines are involved. T346Hunter is freely available at http://bacterial-virulence-factors.cbgp.upm.es/T346Hunter.

  20. Factors Influencing Divergent Patterns of Phosphorus Availability in NY and PA Biogeochemical `Hotspots'

    Science.gov (United States)

    Saia, S. M.; Hofmeister, K.; Regan, J. M.; Buda, A. R.; Carrick, H. J.; Walter, M. T.

    2016-12-01

    Anthropogenic alteration of the soil phosphorus (P) cycle leads to subsequent water quality issues in agricultural dominated watersheds. In the humid Northeastern United States (NE US), variably saturated areas can generate surface runoff that transports P and stimulates biogeochemical processes; these hydrologically dynamic locations are often called biogeochemical `hotspots'. Many studies have evaluated nitrogen and carbon cycling in biogeochemical hot spots but few have focused on P. We hypothesized seasonally wet parts of the landscape (i.e., hotspots) have smaller biologically available P pools because runoff events frequently carry away nutrients like P. To test this hypothesis, we generated soil wetness index (SWI) maps from soil (SURRGO) and elevation (LiDAR rescaled to 3 m) data and used these maps to direct seasonal soil sampling near Klingerstown, Pennsylvania (PA) and Ithaca, New York (NY). We collected 5cm deep soil samples in PA (bimonthly) and NY (monthly) along soil moisture gradients for a range of land cover types (forest, fallow, and cropped) from May through October. We measured soil moisture in the field and percent organic matter (OM), pH, and three increasingly strong soil P extractions (dilute-salt-extractable P, oxalate-extractable P, and total-extractable P) in the laboratory. Our results indicated a negative relationship between dilute-salt-extractable P concentrations and SWI in PA and no relationship between these same variables in NY. We also found positive relationships between each of the three P extractions in PA but only a positive relationship between oxalate-extractable P and total-extractable P in NY. Our findings in PA support our hypothesis; namely, less biologically available P (i.e. dilute-salt-extractable P) is found in wetter areas of the landscape. However, divergent P availability patterns in NY point to further complexities and confounding variables in our understanding in soil P processes. Further studies will look

  1. Efficient in vivo priming by vaccination with recombinant NY-ESO-1 protein and CpG in antigen naive prostate cancer patients.

    Science.gov (United States)

    Karbach, Julia; Neumann, Antje; Atmaca, Akin; Wahle, Claudia; Brand, Kathrin; von Boehmer, Lotta; Knuth, Alexander; Bender, Armin; Ritter, Gerd; Old, Lloyd J; Jäger, Elke

    2011-02-15

    NY-ESO-1, one of the most immunogenic tumor antigens, is expressed in 15% to 25% of metastatic prostate cancers. The immunological and clinical effects of vaccination with recombinant NY-ESO-1 protein combined with CpG as adjuvant were evaluated. In a phase I clinical study, patients with advanced prostate cancer were vaccinated with recombinant NY-ESO-1 protein (100 μg) mixed with CpG 7909 (2.5 mg) every 3 weeks intradermally for 4 doses. Objectives of the study were the safety of the vaccine and changes of specific humoral and cellular immunological responses to NY-ESO-1 in relation to detectable NY-ESO-1 expression in the individual tumor. All 12 baseline sero-negative patients developed high-titer NY-ESO-1 antibody responses. B-cell epitope mapping identified NY-ESO-1 p91-110 to be recognized most frequently by vaccine-induced antibodies. Two patients developed significant antibody titers against the adjuvant CpG. NY-ESO-1-specific CD4+ and/or CD8+ T-cell responses were induced in 9 patients (69%). Five of these 9 patients did not express NY-ESO-1 in the autologous tumor. Postvaccine CD8+ T-cell clones recognized and lyzed HLA-matched tumor cell lines in an antigen-specific manner. Our data provide clear evidence for the capacity of NY-ESO-1 protein/CpG vaccine to induce integrated antigen-specific immune responses in vivo and to efficiently prime CD8+ T-cell responses in NY-ESO-1 antigen-negative patients. Our results may also support further clinical vaccination protocols with NY-ESO-1 protein not only focused on the treatment of existing cancer, but also to prevent further development of NY-ESO-1 positive cancers in vivo. ©2010 AACR.

  2. Dose-dependent effects of NY-ESO-1 protein vaccine complexed with cholesteryl pullulan (CHP-NY-ESO-1) on immune responses and survival benefits of esophageal cancer patients.

    Science.gov (United States)

    Kageyama, Shinichi; Wada, Hisashi; Muro, Kei; Niwa, Yasumasa; Ueda, Shugo; Miyata, Hiroshi; Takiguchi, Shuji; Sugino, Sahoko H; Miyahara, Yoshihiro; Ikeda, Hiroaki; Imai, Naoko; Sato, Eiichi; Yamada, Tomomi; Osako, Masaharu; Ohnishi, Mami; Harada, Naozumi; Hishida, Tadashi; Doki, Yuichiro; Shiku, Hiroshi

    2013-10-05

    Cholesteryl pullulan (CHP) is a novel antigen delivery system for cancer vaccines. This study evaluated the safety, immune responses and clinical outcomes of patients who received the CHP-NY-ESO-1 complex vaccine, Drug code: IMF-001. Patients with advanced/metastatic esophageal cancer were enrolled and subcutaneously vaccinated with either 100 μg or 200 μg of NY-ESO-1 protein complexed with CHP. The primary endpoints were safety and humoral immune responses, and the secondary endpoint was clinical efficacy. A total of 25 patients were enrolled. Thirteen and twelve patients were repeatedly vaccinated with 100 μg or 200 μg of CHP-NY-ESO-1 with a median of 8 or 9.5 doses, respectively. No serious adverse events related to the vaccine were observed. Three out of 13 patients in the 100-μg cohort and 7 out of 12 patients in the 200-μg cohort were positive for anti-NY-ESO-1 antibodies at baseline. In the 100-μg cohort, an antibody response was observed in 5 out of 10 pre-antibody-negatives patients, and the antibody levels were augmented in 2 pre-antibody-positive patients after vaccination. In the 200-μg cohort, all 5 pre-antibody-negative patients became seropositive, and the antibody level was amplified in all 7 pre-antibody-positive patients. No tumor shrinkage was observed. The patients who received 200 μg of CHP-NY-ESO-1 survived longer than patients receiving 100 μg of CHP-NY-ESO-1, even those who exhibited unresponsiveness to previous therapies or had higher tumor burdens. The safety and immunogenicity of CHP-NY-ESO-1 vaccine were confirmed. The 200 μg dose more efficiently induced immune responses and suggested better survival benefits. (Clinical trial registration number NCT01003808).

  3. Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-1 91-110) peptide.

    Science.gov (United States)

    Eikawa, Shingo; Kakimi, Kazuhiro; Isobe, Midori; Kuzushima, Kiyotaka; Luescher, Immanuel; Ohue, Yoshihiro; Ikeuchi, Kazuhiro; Uenaka, Akiko; Nishikawa, Hiroyoshi; Udono, Heiichiro; Oka, Mikio; Nakayama, Eiichi

    2013-01-15

    Immunogenicity of a long 20-mer NY-ESO-1f peptide vaccine was evaluated in a lung cancer patient TK-f01, immunized with the peptide with Picibanil OK-432 and Montanide ISA-51. We showed that internalization of the peptide was necessary to present CD8 T-cell epitopes on APC, contrasting with the direct presentation of the short epitope. CD8 T-cell responses restricted to all five HLA class I alleles were induced in the patient after the peptide vaccination. Clonal analysis showed that B*35:01 and B*52:01-restricted CD8 T-cell responses were the two dominant responses. The minimal epitopes recognized by A*24:02, B*35:01, B*52:01 and C*12:02-restricted CD8 T-cell clones were defined and peptide/HLA tetramers were produced. NY-ESO-1 91-101 on A*24:02, NY-ESO-1 92-102 on B*35:01, NY-ESO-1 96-104 on B*52:01 and NY-ESO-1 96-104 on C*12:02 were new epitopes first defined in this study. Identification of the A*24:02 epitope is highly relevant for studying the Japanese population because of its high expression frequency (60%). High affinity CD8 T-cells recognizing tumor cells naturally expressing the epitopes and matched HLA were induced at a significant level. The findings suggest the usefulness of a long 20-mer NY-ESO-1f peptide harboring multiple CD8 T-cell epitopes as an NY-ESO-1 vaccine. Characterization of CD8 T-cell responses in immunomonitoring using peptide/HLA tetramers revealed that multiple CD8 T-cell responses comprised the dominant response. Copyright © 2012 UICC.

  4. 靶向克隆法构建NY-ESO-1基因的原核表达载体%Construction of NY-ESO-1 Gene Prokaryotic Expression Vector by LP Recco PCR Cloning

    Institute of Scientific and Technical Information of China (English)

    俞远东; 徐少勇; 王斌; 王家宁; 黄永章

    2009-01-01

    目的:利用PCR产物靶向克隆法构建人癌-睾丸抗原NY-ESO-1的原核表达载体.方法:从人新鲜的食管癌组织中提取总RNA,通过RT-PCR技术扩增NY-ESO-1基因3'端的340 bp片段,采用靶向克隆法将目的基因插入到原核表达载体pET-15b中,得到重组表达质粒pET-15b-NY-ESO-1,经过筛选,挑选出阳性克隆进行Xho Ⅰ和BamHⅠ双酶切图谱分析、PCR检测和扩增产物核苷酸序列分析等,鉴定所构建的原核表达载体.结果:扩增得到NY-ESO-1基因片段,经测序证实与GenBank公布的序列一致,重组的质粒经过PCR,酶切鉴定获得了一个大小为340 bp的特征性片段,证明重组质粒中已成功的插入了目的基因NY-ESO-1.结论:靶向克隆法可快速、高效地构建人NY-ESO-1基因的原核表达载体,为制备pET-15b-NY-ESO-1融合蛋白奠定了基础.

  5. Combination of autoantibodies against NY-ESO-1 and viral capsid antigen immunoglobulin A for improved detection of nasopharyngeal carcinoma.

    Science.gov (United States)

    Peng, Yu-Hui; Xu, Yi-Wei; Qiu, Si-Qi; Hong, Chao-Qun; Zhai, Tian-Tian; Li, En-Min; Xu, Li-Yan

    2014-09-01

    Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors in Southern China and Southeast Asia, and early detection remains a challenge. Autoantibodies have been found to precede the manifestations of symptomatic cancer by several months to years, making their identification of particular relevance for early detection. In the present study, the diagnostic value of serum autoantibodies against NY-ESO-1 in NPC patients was evaluated. The study included 112 patients with NPC and 138 normal controls. Serum levels of autoantibodies against NY-ESO-1 and classical Epstein-Barr virus marker, viral capsid antigen immunoglobulin A (VCA-IgA), were measured by enzyme-linked immunosorbent assay. Measurement of autoantibodies against NY-ESO-1 and VCA-IgA demonstrated a sensitivity/specificity of 42.9/94.9% [95% confidence interval (CI), 33.7-52.6/89.4-97.8%] and 55.4/95.7% (95% CI, 45.7-64.7/90.4-98.2%), respectively. The area under receiver operating characteristic curve for autoantibodies against NY-ESO-1 (0.821; 95% CI, 0.771-0.871) was marginally lower than that for VCA-IgA (0.860; 95% CI, 0.810-0.910) in NPC. The combination of autoantibodies against NY-ESO-1 and VCA-IgA yielded an enhanced sensitivity of 80.4% (95% CI, 71.6-87.0%) and a specificity of 90.6% (95% CI, 84.1-94.7%). Moreover, detection of autoantibodies against NY-ESO-1 could differentiate early-stage NPC patients from normal controls. Our results suggest that autoantibodies against NY-ESO-1 may serve as a potential biomarker, as a supplement to VCA-IgA, for the screening and diagnosis of NPC.

  6. Cancer-testis antigen expression in synovial sarcoma: NY-ESO-1, PRAME, MAGEA4, and MAGEA1.

    Science.gov (United States)

    Iura, Kunio; Maekawa, Akira; Kohashi, Kenichi; Ishii, Takeaki; Bekki, Hirofumi; Otsuka, Hiroshi; Yamada, Yuichi; Yamamoto, Hidetaka; Harimaya, Katsumi; Iwamoto, Yukihide; Oda, Yoshinao

    2017-03-01

    Synovial sarcoma (SS) is regarded as a relatively chemosensitive sarcoma, but the prognosis of advanced SSs remains poor. Here we identified highly expressed cancer-testis antigens that could be promising immunotherapy targets for SS, using a previously conducted cDNA microarray, and we assessed the clinicopathological or prognostic relationships of these antigens in SS. We compared the gene expression profiles of 11 SSs with those of 3 normal adipose tissues. Among the up-regulated cancer-testis antigens, we analyzed PRAME, MAGEA1, and MAGEA4 and another cancer-testis antigen (NY-ESO-1) together, by immunohistochemistry and real-time polymerase chain reaction in 108 SSs. Immunohistochemically, NY-ESO-1, PRAME, MAGEA4, and MAGEA1 were positive in 66 (61%), 93 (86%), 89 (82%), and 16 (15%) of 108 SSs, respectively, and 104 (96%) of 108 SSs showed the immunohistochemical expression of at least 1 of NY-ESO-1, PRAME, and MAGEA4. Moreover, the high expression of at least 1 of these 3 antigens was observed in 83% of the SSs. High expression of NY-ESO-1 and MAGEA4 was significantly correlated with the presence of necrosis and advanced clinical stage. The immunohistochemical expression of these cancer-testis antigens was not correlated with prognosis, but the coexpression of NY-ESO-1, PRAME, and MAGEA4 was significantly associated with adverse prognosis. The real-time polymerase chain reaction results were closely related to the immunohistochemical results: NY-ESO-1 (P = .0019), PRAME (P = .039), MAGEA4 (P = .0149), and MAGEA1 (P = .0766). These data support the potential utility of NY-ESO-1, PRAME, and MAGEA4 as immunotherapy targets and ancillary prognostic parameters, suggesting the possible benefit of the combined use of these cancer-testis antigens as an SS immunotherapy target. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation.

    Science.gov (United States)

    Luetkens, Tim; Kobold, Sebastian; Cao, Yanran; Ristic, Marina; Schilling, Georgia; Tams, Sinje; Bartels, Britta Marlen; Templin, Julia; Bartels, Katrin; Hildebrandt, York; Yousef, Sara; Marx, Andreas; Haag, Friedrich; Bokemeyer, Carsten; Kröger, Nicolaus; Atanackovic, Djordje

    2014-11-01

    Multiple myeloma (MM) is the malignancy with the most frequent expression of the highly immunogenic cancer-testis antigens (CTA), and we have performed the first analysis of longitudinal expression, immunological properties, and fine specificity of CTA-specific antibody responses in MM. Frequency and characteristics of antibody responses against cancer-testis antigens MAGE-A3, NY-ESO-1, PRAME, and SSX-2 were analyzed using peripheral blood (N = 1094) and bone marrow (N = 200) plasma samples from 194 MM patients. We found that antibody responses against CTA were surprisingly rare, only 2.6 and 3.1 % of patients evidenced NY-ESO-1- and SSX-2-specific antibodies, respectively. NY-ESO-1-specific responses were observed during disease progression, while anti-SSX-2 antibodies appeared after allogeneic stem cell transplantation and persisted during clinical remission. We found that NY-ESO-1- and SSX-2-specific antibodies were both capable of activating complement and increasing CTA uptake by antigen-presenting cells. SSX-2-specific antibodies were restricted to IgG3, NY-ESO-1 responses to IgG1 and IgG3. Remarkably, NY-ESO-1-positive sera recognized various non-contiguous regions, while SSX-2-specific responses were directed against a single 6mer epitope, SSX-2(85-90). We conclude that primary autoantibodies against intracellular MM-specific tumor antigens SSX-2 and NY-ESO-1 are rare but functional. While their contribution to disease control still remains unclear, our data demonstrate their theoretic ability to affect cellular anti-tumor immunity by formation and uptake of mono- and polyvalent immune complexes.

  8. NY-ESO-1 Vaccination in Combination with Decitabine Induces Antigen-Specific T-Lymphocyte Responses in Patients with Myelodysplastic Syndrome.

    Science.gov (United States)

    Griffiths, Elizabeth A; Srivastava, Pragya; Matsuzaki, Junko; Brumberger, Zachary; Wang, Eunice S; Kocent, Justin; Miller, Austin; Roloff, Gregory W; Wong, Hong Yuen; Paluch, Benjamin E; Lutgen-Dunckley, Linda G; Martens, Brandon L; Odunsi, Kunle; Karpf, Adam R; Hourigan, Christopher S; Nemeth, Michael J

    2017-09-25

    Treatment options are limited for patients with high-risk myelodysplastic syndrome (MDS). The azanucleosides, azacitidine and decitabine, are front-line therapy for MDS that induce promoter demethylation and gene expression of the highly immunogenic tumor antigen NY-ESO-1. We demonstrated that AML patients receiving decitabine exhibit induction of NY-ESO-1 expression in circulating blasts. We hypothesized that vaccinating against NY-ESO-1 in MDS patients receiving decitabine would capitalize upon induced NY-ESO-1 expression in malignant myeloid cells to provoke an NY-ESO-1-specific-MDS directed cytotoxic T-cell immune response. In a phase I study, 9 MDS patients received an HLA unrestricted NY-ESO-1 vaccine (CDX-1401 + poly-ICLC) in a non-overlapping schedule every four weeks with standard dose decitabine. Analysis of samples serially obtained from the 7 patients who reached the end-of-study demonstrated induction of NY-ESO-1 expression in 7/7 patients and NY-ESO-1 specific CD4+ and CD8+ T-lymphocyte responses in 6/7 and 4/7 of the vaccinated patients respectively. Myeloid cells expressing NY-ESO-1, isolated from a patient at different time-points during decitabine therapy, were capable of activating a cytotoxic response from autologous NY-ESO-1-specific T-lymphocytes. Vaccine responses were associated with a detectable population of CD141Hi conventional dendritic cells, which are critical for the uptake of NY-ESO-1 vaccine and have a recognized role in anti-tumor immune responses. These data indicate that vaccination against induced NY-ESO-1 expression can produce an antigen-specific immune response in a relatively non-immunogenic myeloid cancer and highlight the potential for induced-antigen directed immunotherapy in a group of patients with limited options. Copyright ©2017, American Association for Cancer Research.

  9. Håndværk og design; nyt fag, ny didaktik – et aktionsforskningsprojekt

    Directory of Open Access Journals (Sweden)

    Stig Pedersen

    2011-11-01

    Full Text Available Projektet tager afsæt i regeringens forslag om at sammenlægge fagene sløjd og håndarbejde til et nyt fag ”håndværk og design”. Det er projektets ambition at være dagsordensættende i forhold til udvikling af dette nye skolefag. Vi vil arbejde ud fra en aktionsforskningsmæssig tilgang. Det betyder, at vi ikke alene har til hensigt at etablere et ”objektivt” billede af, hvordan udvalgte skoler arbejder med at udvikle det ny fag ”håndværk og design”, men ønsker at påvirke udviklingen og dermed i fællesskab konstruere ny didaktisk teori. Som støtte for projektgruppens arbejde nedsættes en metodisk, didaktisk studiekreds, hvor projektgruppen modtager sparring fra erfarne forskere. Det er projektets sigte at undersøge og udvikle det ny fags didaktik med henblik på at generere visioner for bl.a. indholdsudvælgelse og læreformer i et fremtidsperspektiv for faget ”håndværk og design” i samspil mellem de ideer, viden og erfaringer forskerne har, den viden og erfaring de udvalgte forskende lærere har, samt de erfaringer og ideer, der opbygges i projektets praksisdele. Der arbejdes med eksemplariske forløb, som planlægges og efterbehandles i samarbejde mellem lærere og forskere. Dette samarbejde dokumenteres af lærerne og projektgruppens medlemmer i fællesskab. Her indgår fx undervisningsoplæg, materialer og genstande, evalueringsformer – og resultater samt fokusgruppe interview.Søkord: metod, sløjd, håndværk og design, aktionsforskning, folkeskolenURN:NBN:no-29962

  10. Prevalence of Toxoplasma gondii antibodies in hunter-killed white-tailed deer (Odocoileus virginianus) in four regions of Minnesota.

    Science.gov (United States)

    Vanek, J A; Dubey, J P; Thulliez, P; Riggs, M R; Stromberg, B E

    1996-02-01

    Sera from 1,367 white-tailed deer (Odocoileus virginianus) from 4 geographic regions in Minnesota collected during 4 hunting seasons (1990-1993) were tested for antibodies to Toxoplasma gondii using the modified direct agglutination test incorporating mercaptoethanol. Sera from 30% of the deer had antibody titers > or = 25; 8.6% were positive at a titer of 25, 11% at a titer of 50, and 10% at a titer > or = 500. There was a significant increase in seropositivity with age (P oak suburban park land. There were no statistically significant differences by year of collection. The prevalence of T. gondii antibodies in white-tailed deer remains high and deer hunters and consumers should ensure that venison is well-cooked or frozen prior to consumption.

  11. Effect of Resource Spatial Correlation and Hunter-Fisher-Gatherer Mobility on Social Cooperation in Tierra del Fuego

    Science.gov (United States)

    Santos, José Ignacio; Pereda, María; Zurro, Débora; Álvarez, Myrian; Caro, Jorge; Galán, José Manuel; Briz i Godino, Ivan

    2015-01-01

    This article presents an agent-based model designed to explore the development of cooperation in hunter-fisher-gatherer societies that face a dilemma of sharing an unpredictable resource that is randomly distributed in space. The model is a stylised abstraction of the Yamana society, which inhabited the channels and islands of the southernmost part of Tierra del Fuego (Argentina-Chile). According to ethnographic sources, the Yamana developed cooperative behaviour supported by an indirect reciprocity mechanism: whenever someone found an extraordinary confluence of resources, such as a beached whale, they would use smoke signals to announce their find, bringing people together to share food and exchange different types of social capital. The model provides insight on how the spatial concentration of beachings and agents’ movements in the space can influence cooperation. We conclude that the emergence of informal and dynamic communities that operate as a vigilance network preserves cooperation and makes defection very costly. PMID:25853728

  12. A new mutation (1062 del 16) of iduronate-2-sulfatase gene from a Chinese patient with Hunter syndrome

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective: To identify the mutations of iduronate-2-sulfatase (IDS) gene, to reveal its mutation features, and to establish a basis for genetic counseling and prenatal gene diagnosis of Hunter syndrome. Methods: Urine glycosaminoglycans (GAGs) assay, PCR and DNA sequencing were performed to detect mutation of IDS gene of the patient and his parents. Results:The result showed that the patient was: DS(++), HS(++), KS(-), CS(-), and that both of his parents were negative. A frame-shift deletion mutation (1062 del 16) was identified in exon 7 of the patient's IDS gene. His parents'genotypes were normal. Conclusion: The patient's mutation was not inherited by his parents but a novel one. The mutation probably altered the primary structure and tertiary structure of IDS enzyme protein remarkably and lowered the activity of IDS enzyme greatly. Therefore it is supposed to be the direct cause of the disorder.

  13. Effect of resource spatial correlation and hunter-fisher-gatherer mobility on social cooperation in Tierra del Fuego.

    Science.gov (United States)

    Santos, José Ignacio; Pereda, María; Zurro, Débora; Álvarez, Myrian; Caro, Jorge; Galán, José Manuel; Briz i Godino, Ivan

    2015-01-01

    This article presents an agent-based model designed to explore the development of cooperation in hunter-fisher-gatherer societies that face a dilemma of sharing an unpredictable resource that is randomly distributed in space. The model is a stylised abstraction of the Yamana society, which inhabited the channels and islands of the southernmost part of Tierra del Fuego (Argentina-Chile). According to ethnographic sources, the Yamana developed cooperative behaviour supported by an indirect reciprocity mechanism: whenever someone found an extraordinary confluence of resources, such as a beached whale, they would use smoke signals to announce their find, bringing people together to share food and exchange different types of social capital. The model provides insight on how the spatial concentration of beachings and agents' movements in the space can influence cooperation. We conclude that the emergence of informal and dynamic communities that operate as a vigilance network preserves cooperation and makes defection very costly.

  14. Framtagning av ny lyftytrystning för gasturbin SGT-600/700

    OpenAIRE

    Sjöberg, Emma

    2008-01-01

    I detta Examensarbete har en ny lyftutrustning till gasturbin SGT-600/700 olika moduler tagits fram. Examensarbetet har utförts på Siemens Industrial Turbomachinery AB i Finspång på avdelningen GPTP (leverans gasturbin teknik package installation). Målet med arbetet har varit att skapa en lyftutrustning som är mer flexibel än den befintliga lyftutrustningen och klarar samlyft (lyft med hjälp av två kranar). Arbetet har utförts med hjälp av olika metoder som QFD, funktionsmedel-träd och morpho...

  15. Primes of the form x2+ny2 Fermat, class field theory, and complex multiplication

    CERN Document Server

    Cox, David A

    2014-01-01

    An exciting approach to the history and mathematics of number theory ". . . the author's style is totally lucid and very easy to read . . .the result is indeed a wonderful story." -Mathematical ReviewsWritten in a unique and accessible style for readers of varied mathematical backgrounds, the Second Edition of Primes of the Form p = x2+ ny2 details the history behind how Pierre de Fermat's work ultimately gave birth to quadratic reciprocity and the genus theory of quadratic forms. The book also illustrates how results of Euler and Gauss can be fully understood only in the context of class fi

  16. Boktrailern – : En kartläggning av en ny medieprodukt

    OpenAIRE

    Rybin, Claudia

    2015-01-01

    I detta examensarbete kartlägger jag en ny medieprodukt, boktrailern. En boktrailer är en audiovisuell reklam för en bok och härstammar från samt följer dels samma konventioner som den etablerade filmtrailertraditionen. I vissa fall kan boktrailern även ses som en självständig kortfilm. Boktrailern har uppkommit vid sekelskiftet och utvecklats som en följd av tre faktorer kopplade till tjugohundratalets teknologiska framsteg: 1. Verbal text är allt mer tvungen att förlita sig på ...

  17. Networks of Food Sharing Reveal the Functional Significance of Multilevel Sociality in Two Hunter-Gatherer Groups.

    Science.gov (United States)

    Dyble, Mark; Thompson, James; Smith, Daniel; Salali, Gul Deniz; Chaudhary, Nikhil; Page, Abigail E; Vinicuis, Lucio; Mace, Ruth; Migliano, Andrea Bamberg

    2016-08-01

    Like many other mammalian and primate societies [1-4], humans are said to live in multilevel social groups, with individuals situated in a series of hierarchically structured sub-groups [5, 6]. Although this multilevel social organization has been described among contemporary hunter-gatherers [5], questions remain as to the benefits that individuals derive from living in such groups. Here, we show that food sharing among two populations of contemporary hunter-gatherers-the Palanan Agta (Philippines) and Mbendjele BaYaka (Republic of Congo)-reveals similar multilevel social structures, with individuals situated in households, within sharing clusters of 3-4 households, within the wider residential camps, which vary in size. We suggest that these groupings serve to facilitate inter-sexual provisioning, kin provisioning, and risk reduction reciprocity, three levels of cooperation argued to be fundamental in human societies [7, 8]. Humans have a suite of derived life history characteristics including a long childhood and short inter-birth intervals that make offspring energetically demanding [9] and have moved to a dietary niche that often involves the exploitation of difficult to acquire foods with highly variable return rates [10-12]. This means that human foragers face both day-to-day and more long-term energetic deficits that conspire to make humans energetically interdependent. We suggest that a multilevel social organization allows individuals access to both the food sharing partners required to buffer themselves against energetic shortfalls and the cooperative partners required for skill-based tasks such as cooperative foraging.

  18. Establishment of native and exotic grasses on mine overburden and topsoil in the Hunter Valley, New South Wales

    Energy Technology Data Exchange (ETDEWEB)

    Huxtable, C.H.A.; Koen, T.B.; Waterhouse, D. [DNR, Dangar, NSW (Australia)

    2005-07-01

    Current recommendations for rehabilitation of open-cut coal mines in the Hunter Valley involve the sowing of exotic pasture species to reinstate mined land to Class IV and V under the Rural Land Capability System. Despite the importance of native grasses in the pre-mined landscape, they are currently not widely included in mine rehabilitation. To address this issue a project was conducted between 1994 and 2000 to research the use of native grasses for rehabilitation of open-cut coal mines in the Hunter Valley. This paper reports on 2 mine site experiments that aimed to assess establishment and persistence of a broad range of native and exotic grass species from an autumn sowing in both topsoil and raw spoil over a period of 61 months. The most promising natives in terms of early establishment, persistence and spread over time, included six C-3 accessions (five Austrodanthonia spp. and Austrostipa bigeniculata) and one C-4 accession (Cynodon dactylon). Persistence of these accessions was better in raw spoil than topsoil, despite initial low numbers, due to a lack of weed competition and their ability to spread by self-seeding. In topsoil, and in the absence of any biomass reduction, native species were mostly out-competed by vigorous exotic perennial grasses which were sown in these experiments and from seed influx from adjacent rehabilitation areas or from the soil seed bank. The effects of climatic conditions and differences in soil physical, chemical and seed bank characteristics at the 2 mine sites are also discussed.

  19. Diagnosis of tuberculosis in the wild boar (Sus scrofa: a comparison of methods applicable to hunter-harvested animals.

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    Nuno Santos

    Full Text Available BACKGROUND: To obtain robust epidemiological information regarding tuberculosis (TB in wildlife species, appropriate diagnostic methods need to be used. Wild boar (Sus scrofa recently emerged as a major maintenance host for TB in some European countries. Nevertheless, no data is available to evaluate TB post-mortem diagnostic methods in hunter-harvested wild boar. METHODOLOGY/PRINCIPAL FINDINGS: Six different diagnostic methods for TB were evaluated in parallel in 167 hunter-harvested wild boar. Compared to bacteriological culture, estimates of sensitivity of histopathology was 77.8%, gross pathology 72.2%, PCR for the MPB70 gene 66.7%, detection of acid-fast bacilli (AFB in tissue contact smears 55.6% and in histopathology slides 16.7% (estimated specificity was 96.7%, 100%, 100%, 94.4% and 100%, respectively. Combining gross pathology with stained smears in parallel increased estimated sensitivity to 94.4% (94.4% specificity. Four probable bacteriological culture false-negative animals were identified by Discriminant Function Analysis. Recalculating the parameters considering these animals as infected generated estimated values for sensitivity of bacteriology and histopathology of 81.8%, gross pathology 72.7%, PCR for the MPB70 gene 63.6%, detection of AFB in tissue contact smears 54.5% and in histopathology slides 13.6% (estimated specificity was 100% for gross pathology, PCR, bacteriology and detection of AFB in histopathology slides, 96.7% for histopathology and 94.4% for stained smears. CONCLUSIONS/SIGNIFICANCE: These results show that surveys for TB in wild boar based exclusively on gross pathology considerably underestimate prevalence, while combination of tests in parallel much improves sensitivity and negative predictive values. This finding should thus be considered when planning future surveys and game meat inspection schemes. Although bacteriological culture is the reference test for TB diagnosis, it can generate false

  20. Site Formation Processes and Hunter-Gatherers Use of Space in a Tropical Environment: A Geo-Ethnoarchaeological Approach from South India.

    Science.gov (United States)

    Friesem, David E; Lavi, Noa; Madella, Marco; Ajithprasad, P; French, Charles

    2016-01-01

    Hunter-gatherer societies have distinct social perceptions and practices which are expressed in unique use of space and material deposition patterns. However, the identification of archaeological evidence associated with hunter-gatherer activity is often challenging, especially in tropical environments such as rainforests. We present an integrated study combining ethnoarchaeology and geoarchaeology in order to study archaeological site formation processes related to hunter-gatherers' ways of living in tropical forests. Ethnographic data was collected from an habitation site of contemporary hunter-gatherers in the forests of South India, aimed at studying how everyday activities and way of living dictate patterns of material deposition. Ethnoarchaeological excavations of abandoned open-air sites and a rock-shelter of the same group located deep in the forests, involved field observations and sampling of sediments from the abandoned sites and the contemporary site. Laboratory analyses included geochemical analysis (i.e., FTIR, ICP-AES), phytolith concentration analysis and soil micromorphology. The results present a dynamic spatial deposition pattern of macroscopic, microscopic and chemical materials, which stem from the distinctive ways of living and use of space by hunter-gatherers. This study shows that post-depositional processes in tropical forests result in poor preservation of archaeological materials due to acidic conditions and intensive biological activity within the sediments. Yet, the multiple laboratory-based analyses were able to trace evidence for activity surfaces and their maintenance practices as well as localized concentrations of activity remains such as the use of plants, metals, hearths and construction materials.