WorldWideScience

Sample records for human-induced radio noise

  1. RADIO NOISE ADVANCES SEXUAL MATURITY

    African Journals Online (AJOL)

    ansistf-lewis

    Mean age at first egg for the radio birds (143 d) was 13 d significantly earlier than controls, but body weight at ... the first 8 h of a 12-h photoperiod with radio noise, to leave only 4 h of light (4L:20D), supported rates of lay ... Age (AFE) and body weight at, and weight of, first egg were recorded for individual birds, and, after a.

  2. Radio Astronomy Explorer /RAE/. I - Observations of terrestrial radio noise.

    Science.gov (United States)

    Herman, J. R.; Caruso, J. A.; Stone, R. G.

    1973-01-01

    Radio Astronomy Explorer (RAE) I data are analyzed to establish characteristics of HF terrestrial radio noise at an altitude of about 6000 km. Time and frequency variations in amplitude of the observed noise well above cosmic noise background are explained on the basis of temporal and spatial variations in ionospheric critical frequency coupled with those in noise source distributions. It is shown that terrestrial radio noise regularly breaks through the ionosphere and reaches RAE with magnitudes 15 dB and more above cosmic noise background, on frequencies above the F-layer critical frequency.

  3. Radio Astronomy Explorer (RAE) 1 observations of terrestrial radio noise

    Science.gov (United States)

    Herman, J. R.; Caruso, J. A.

    1971-01-01

    Radio Astonomy Explorer (RAE) 1 data are analyzed to establish characteristics of HF terrestrial radio noise at an altitude of about 6000 km. Time and frequency variations in amplitude of the observed noise well above cosmic noise background are explained on the basis of temporal and spatial variations in ionospheric critical frequency coupled with those in noise source distributions. It is shown that terrestrial noise regularly breaks through the ionosphere and reaches RAE with magnitudes 15 or more db higher than cosmic noise background. Maximum terrestrial noise is observed when RAE is over the dark side of the Earth in the neighborhood of equatorial continental land masses where thunderstorms occur most frequently. The observed noise level is 30-40 db lower with RAE over oceans.

  4. Cosmic noise: a history of early radio astronomy

    National Research Council Canada - National Science Library

    Sullivan, Woodruff Turner

    2009-01-01

    .... The whole of worldwide radio and radar astronomy is covered, beginning with the discoveries by Jansky and Reber of cosmic noise before World War II, through the wartime detections of solar noise...

  5. Noise and intercept point calculation for modern radio receiver planning

    DEFF Research Database (Denmark)

    Iversen, Christian Rye; Kolding, T. E.

    2001-01-01

    The paper presents analytical expressions for determining noise and intercept points for cascaded radio receiver stages. The theory allows for active receiver stages with frequency selectivity and flexible impedance levels. This makes the method highly usable for planning of modem receivers where...

  6. Modal noise impact in radio over fiber multimode fiber links.

    Science.gov (United States)

    Gasulla, I; Capmany, J

    2008-01-07

    A novel analysis is given on the statistics of modal noise for a graded-index multimode fiber (MMF) link excited by an analog intensity modulated laser diode. We present the speckle contrast as a function of the power spectrum of the modulated source and the transfer function of the MMF which behaves as an imperfect transversal microwave photonic filter. The theoretical results confirm that the modal noise is directly connected with the coherence properties of the optical source and show that the performance of high-frequency Radio Over Fiber (ROF) transmission through MMF links for short and middle reach distances is not substantially degraded by modal noise.

  7. Absorption of cosmic radio noise at different frequencies at Sanae

    International Nuclear Information System (INIS)

    Steyn, T.F.J.

    1983-12-01

    Electron density profiles are simulated as a function of altitude for the D- and E-regions during disturbed ionospheric conditions using auroral absorption data from riometers recording cosmic radio noise at 20, 30 and 51 MHz at Sanae, Antarctica. An elliptical function was used to simulate, as a function of height, the electron density profiles. Using these profiles the measured absorption was calculated by utilizing the Appleton-Hartree treatment for radio waves crossing the ionosphere. The frequency dependence of the riometer absorption is represented by a power law of the frequency: A(f) = C.f -n , and values of n were determined from calculations of the absorptions from the simulated electron density profiles. This power law is a fairly accurate representation in the frequency range 20 to 51 MHz. It appears that the exponent of the power law and the height of maximum absorption are effective parameters to determine the hardness of the energy spectra of precipitating electrons. A method is discussed whereby interferences on the riometer recordings are filtered from the data. Quiet day curves are obtained by the superposition of successive riometer recordings with a period of one sidereal day. A Fourier series is fitted to the points of maximum density to represent the quiet day recordings. Absorption events on day 175 and day 178 (1982) are analized for each riometer frequency, and the hardness of the precipitating electrons is inferred from the n-values of power law presentation. It is shown that the absorption of cosmic radio noise increases by increasing the depth of ionization without increasing the ionization rate (number of electrons /m 3 ) in the upper D-region. This may mean that a hardening of a precipitation spectrum will increase the absorption of cosmic radio noise

  8. A novel method for the evaluation of polarization and hemisphere coverage of HF radio noise measurement antennas

    NARCIS (Netherlands)

    Witvliet, Ben A.; van Maanen, Erik; Bentum, Mark J.; Slump, Cornelis H.; Schiphorst, Roel

    2015-01-01

    In HF (3-30 MHz) communications the ambient electromagnetic background noise or 'radio noise' generally is the limiting factor in reception. Radio noise measurements are needed for spectrum pollution control and to provide reference levels for radio system design. This article discusses the

  9. Noise

    Science.gov (United States)

    Noise is all around you, from televisions and radios to lawn mowers and washing machines. Normally, you ... sensitive structures of the inner ear and cause noise-induced hearing loss. More than 30 million Americans ...

  10. Self-noise in interferometers - radio and infrared

    International Nuclear Information System (INIS)

    Kulkarni, S.R.

    1989-01-01

    A complete theory of noise in a synthesis image is proposed for a source of arbitrary strength. In the limit of faint sources, the standard estimates of noise in a synthesis image are recovered, while in the limit of strong sources, the noise in the synthesis image is found to be dominated by either self noise or by the noise generated by the source signal itself. It is found that the best VLBI maps (with noise approaching the thermal noise) may in fact be limited by self noise, and that there is a negligible bias in the standard definitions of the bispectrum phasor and the closure phase. The results suggest that at the low signal levels which are characteristic of infrared interferometers, it is best to fit the model to all the closure phases and fringe amplitudes. 13 refs

  11. Supplementary radio noise advances sexual maturity in domestic ...

    African Journals Online (AJOL)

    Plasma melatonin concentrations midway through the 7-h dark period in which the radio was played were similar to those of non-radio controls, indicating that this period was not regarded as being part of a 14-h subjective day. Keywords: Environmental cue; sound; sexual maturity. South African Journal of Animal Sciences ...

  12. SOLAR RADIO TYPE-I NOISE STORM MODULATED BY CORONAL MASS EJECTIONS

    International Nuclear Information System (INIS)

    Iwai, K.; Tsuchiya, F.; Morioka, A.; Misawa, H.; Miyoshi, Y.; Masuda, S.; Shimojo, M.; Shiota, D.; Inoue, S.

    2012-01-01

    The first coordinated observations of an active region using ground-based radio telescopes and the Solar Terrestrial Relations Observatory (STEREO) satellites from different heliocentric longitudes were performed to study solar radio type-I noise storms. A type-I noise storm was observed between 100 and 300 MHz during a period from 2010 February 6 to 7. During this period the two STEREO satellites were located approximately 65° (ahead) and –70° (behind) from the Sun-Earth line, which is well suited to observe the earthward propagating coronal mass ejections (CMEs). The radio flux of the type-I noise storm was enhanced after the preceding CME and began to decrease before the subsequent CME. This time variation of the type-I noise storm was directly related to the change of the particle acceleration processes around its source region. Potential-field source-surface extrapolation from the Solar and Heliospheric Observatory/Michelson Doppler Imager (SOHO/MDI) magnetograms suggested that there was a multipolar magnetic system around the active region from which the CMEs occurred around the magnetic neutral line of the system. From our observational results, we suggest that the type-I noise storm was activated at a side-lobe reconnection region that was formed after eruption of the preceding CME. This magnetic structure was deformed by a loop expansion that led to the subsequent CME, which then suppressed the radio burst emission.

  13. Snow noise disturbance in Antarctic radio communications and development of mobile antenna for snow vehicle in Antarctica

    Directory of Open Access Journals (Sweden)

    Isao Fukushima

    1997-07-01

    Full Text Available Radio operators of the Japanese Antarctic Research Expedition (JARE have encountered critical radio noise disturbances caused by blizzards during oversnow travel. This noise appears to be caused by corona discharge at the edges of the vertical whip antenna. This paper describes several examples of snow noise experienced in Antarctica by JARE, the mechanism of generation of the noise, and a method of reducing the intensity of the noise. It also describes a High Effeciency Transmission Line Antenna which is small enough to mount on a snow vehicle and reduces the intensity of the snow noise.

  14. Deka-keV X-ray emission associated with the onset of radio noise storms

    DEFF Research Database (Denmark)

    Crosby, N.; Vilmer, N.; Lund, Niels

    1996-01-01

    Radio noise storms show that suprathermal electrons (a few tens of keV) are present in the vicinity of active regions during several hours or even a few days. Where and how these electrons are energized is not yet well known. A flare-like sudden energy release in the active region is in general o...

  15. Radio frequency interference noise reduction using a field programmable gate array for SQUID applications

    International Nuclear Information System (INIS)

    Sakuta, K; Narita, Y; Itozaki, H

    2007-01-01

    It is important to remove large environmental noise in superconducting quantum interference device (SQUID) measurement without magnetic shielding. Active noise control (ANC) is one of the effective methods to reduce environmental noise. Recently, SQUIDs have been used in various applications at high frequencies, such as nuclear quadrupole resonance (NQR). The NQR frequency from explosives is in the range 0.5-5 MHz. In this case, an NQR sensor is exposed to AM radio frequency interference (RFI). The feasibility of the ANC system for RFI that used digital signal processing was studied. Our investigation showed that this digital ANC system can be applied to SQUID measurements for RFI suppression

  16. Cosmic Noise: The Pioneers of Early Radio Astronomy and Their Discoveries

    Science.gov (United States)

    Sullivan, Woodruff T., III

    2012-01-01

    Extraterrestrial radio waves (the galactic background), often referred to as "cosmic noise", were first detected accidentally by Karl Jansky at a frequency of 20 MHz in 1932, with significant followup by Grote Reber. Yet after World War II it was England and Australia that dominated the field. An entirely different sky from that of visual astronomy was revealed by the discoveries of solar noise, "radio stars” (discrete sources such as Cas A, Tau A, Cyg A, Cen A and Vir A), galactic noise, lunar and meteor radar experiments, the detection of the 21 cm hydrogen line, and eventually optical identifications such as the Crab Nebula and M87. Key players included wartime radar experts such as Stanley Hey (the British Army's Operational Research Group), Martin Ryle (Cambridge University), Bernard Lovell (Jodrell Bank) and Joe Pawsey (Radiophysics Lab, Sydney). Younger leaders also emerged such as Graham Smith, Tony Hewish, John Davies, "Chris" Christiansen, Bernie Mills, Paul Wild, and John Bolton. Some optical astronomers (Jan Oort, Henk van de Hulst, Jesse Greenstein, Rudolph Minkowski, and Walter Baade) were also extremely supportive. By the end of the postwar decade, radio astronomy was firmly established within the gamut of astronomy, although very few of its practitioners had been trained as astronomers. I will also trace the technical and social aspects of this wholly new type of astronomy, with special attention on military and national influences. I argue that radio astronomy represents one of the key developments in twentieth century astronomy not only because of its own discoveries, but also its pathfinding for the further opening the electromagnetic spectrum. This study is based on exhaustive archival research and over one hundred interviews with pioneering radio astronomers. Full details are available in the book "Cosmic Noise: A History of Early Radio Astronomy" (Cambridge Univ. Pr.).

  17. Energetics of small electron acceleration episodes in the solar corona from radio noise storm observations

    Science.gov (United States)

    James, Tomin; Subramanian, Prasad

    2018-05-01

    Observations of radio noise storms can act as sensitive probes of nonthermal electrons produced in small acceleration events in the solar corona. We use data from noise storm episodes observed jointly by the Giant Metrewave Radio Telescope (GMRT) and the Nancay Radioheliograph (NRH) to study characteristics of the nonthermal electrons involved in the emission. We find that the electrons carry 1021 to 1024 erg/s, and that the energy contained in the electrons producing a representative noise storm burst ranges from 1020 to 1023 ergs. These results are a direct probe of the energetics involved in ubiquitous, small-scale electron acceleration episodes in the corona, and could be relevant to a nanoflare-like scenario for coronal heating.

  18. Observations of a low-frequency cutoff in magnetospheric radio noise received on Imp 6

    International Nuclear Information System (INIS)

    Vesecky, J.F.; Frankel, M.S.

    1975-01-01

    Observations of magnetospheric radio noise by the Goddard Space Flight Center radio experiment on the Imp 6 spacecraft have revealed a quasi-continuous component at frequencies between 30 and 110 kHz. When the spacecraft is in the interplanetary medium or the magnetosheath, a low-frequency cutoff often characterizes the otherwise power law (f - /sup alpha/) spectrum of this noise. A positive correlation is observed between this cutoff frequency f) and the solar wind plasma frequency f), deduced from the Los Alamos plasma experiment on the same spacecraft; on the average, f)approx. =1.3f). If one pictures the magnetosheath as a homogeneous layer of plasma lying between the radio noise source (at Lapprox.4--7) and the spacecraft in the interplanetary medium and having an electron density 2--3 times that of the solar wind, then one will expect f)approximately-greater-than2 1 / 2 f)--3 1 / 2 f). Within the limits of experimental error this simple model correctly accounts for the observations. A rough calculation shows that radio wave scattering by electron density fluctuations in the magnetosheath plasma is likely to be important for frequencies below 200 kHz. However, the effects of such scattering cannot be detected in the Imp 6 observations considered here because neither concurrent measurements nor sufficiently accurate models of the necessar []magnetosheath plasma parameters are presently available

  19. Propagation effects on radio range and noise in earth-space telecommunications

    Science.gov (United States)

    Flock, W. L.; Slobin, S. D.; Smith, E. K.

    1982-01-01

    Attention is given to the propagation effects on radio range and noise in earth-space telecommunications. The use of higher frequencies minimizes ionospheric effects on propagation, but tropospheric effects often increase or dominate. For paths of geostationary satellites, and beyond, the excess range delay caused by the ionosphere and plasmasphere is proportional to the total electron content along the path and inversely proportional to frequency squared. The delay due to dry air is usually of the order of a few meters while the delay due to water vapor (a few tens of centimeters) is responsible for most of the temporal variation in the range delay for clean air. For systems such as that of the Voyager spacecraft, and for attenuation values up to about 10 dB, increased sky noise degrades the received signal-to-noise ratio more than does the reduction in signal level due to attenuation.

  20. Evolution of extra-galactic nebulae and the origin of metagalactic radio noise

    International Nuclear Information System (INIS)

    Bruce, C.E.R.

    1975-01-01

    It is pointed out that the discovery of the 'jet' in the radio source NGC 4486 fulfils a prediction made many years ago that such 'jets' would exist in some globular or elliptical nebulae. They are the channels of electrical discharges on a nebular scale then postulated, which will last for about 10 million years. It is emphasized that the discharge hypothesis would account for - 1. the existence of irregular nebulae; 2. the 'cataclysmic action' which Hubble regarded as required to account for the transition from nebulae of Type E to Type Sa; 3. the fact that the arms of spiral nebulae are never seen in process of formation; 4. the gathering of the matter towards the discharge channels by magnetic pinch effect; 5. the frequent occurrence of two diametrically opposed major arms; 6. the origin of radio waves throughout an extensive volume of space surrounding the 'jet' or discharge channel in NGC 4486; 7. the effect of one extra galactic nebula, NGC 3187, on another, NGC 3190; 8. the existence of diffuse patches of luminosity, 'emission nebulae', in the spiral arms of our own galaxy and in those of the 'Andromeda Nebula'. On the discharge theory about one per cent of all nebulae will be passing through the discharge phase at any one time, i.e., the number required to account for the observed intensity of metagalactic radio noise. (author)

  1. Opto-Electromechanical Devices for Low-Noise Detection of Radio Waves

    DEFF Research Database (Denmark)

    Bagci, Tolga

    factors. For example, a hybrid system like this, would enable the use of well-established shot-noise limited optical sensing technologies for detecting weak radio-frequency (rf) signals, rf-to-optical photon conversion and transmission of information in low-loss fiber-optic links over long distances......There is currently an increasing interest in developing hybrid devices that unite the desirable features of different systems. Opto-electromechanics has emerged as one of these promising hybrid fields, where the functionality of conventional electrical circuits can be combined with the salient...... features of optical systems for various technological and sensing applications. Nanomechanical resonators stand as promising candidates in terms of linking the two systems, primarily thanks to their versatility in coupling to various physical systems, together with their excellent mechanical quality...

  2. Cosmic radio-noise absorption bursts caused by solar wind shocks

    Directory of Open Access Journals (Sweden)

    A. Osepian

    2004-09-01

    Full Text Available Bursts of cosmic noise absorption observed at times of sudden commencements (SC of geomagnetic storms are examined. About 300SC events in absorption for the period 1967-1990 have been considered. It is found that the response of cosmic radio-noise absorption to the passage of an interplanetary shock depends on the level of the planetary magnetic activity preceding the SC event and on the magnitude of the magnetic field perturbation associated with the SC (as measured in the equatorial magnetosphere. It is shown that for SC events observed against a quiet background (Kp<2, the effects of the SC on absorption can be seen only if the magnitude of the geomagnetic field perturbation caused by the solar wind shock exceeds a threshold value ΔBth. It is further demonstrated that the existence of this threshold value, ΔBth, deduced from experimental data, can be related to the existence of a threshold for exciting and maintaining the whistler cyclotron instability, as predicted by quasi-linear theory. SC events observed against an active background (Kp<2 are accompanied by absorption bursts for all magnetic field perturbations, however small. A quantitative description of absorption bursts associated with SC events is provided by the whistler cyclotron instability theory.

  3. Time Delay Mechanical-noise Cancellation (TDMC) to Provide Order of Magnitude Improvements in Radio Science Observations

    Science.gov (United States)

    Atkinson, D. H.; Babuscia, A.; Lazio, J.; Asmar, S.

    2017-12-01

    Many Radio Science investigations, including the determinations of planetary masses, measurements of planetary atmospheres, studies of the solar wind, and solar system tests of relativistic gravity, rely heavily on precision Doppler tracking. Recent and currently proposed missions such as VERITAS, Bepi Colombo, Juno have shown that the largest error source in the precision Doppler tracking data is noise in the Doppler system. This noise is attributed to un-modeled motions of the ground antenna's phase center and is commonly referred to as "antenna mechanical noise." Attempting to reduce this mechanical noise has proven difficult since the deep space communications antennas utilize large steel structures that are already optimized for mechanical stability. Armstrong et al. (2008) have demonstrated the Time Delay Mechanical-noise Cancellation (TDMC) concept using Goldstone DSN antennas (70 m & 34 m) and the Cassinispacecraft to show that the mechanical noise of the 70 m antenna could be suppressed when two-way Doppler tracking from the 70 m antenna and the receive-only Doppler data from the smaller, stiffer 34 m antenna were combined with suitable delays. The proof-of-concept confirmed that the mechanical noise in the final Doppler observable was reduced to that of the stiffer, more stable antenna. Caltech's Owens Valley Radio Observatory (OVRO) near Bishop, CA now has six 10.4 m diameter antennas, a consequence of the closure of Combined Array for Research in Millimeter Astronomy (CARMA). In principle, a 10 m antenna can lead to an order-of-magnitude improvement for the mechanical noise correction, as the smaller dish offers better mechanical stability compared to a DSN 34-m antenna. These antennas also have existing Ka-band receiving systems, and preliminary discussions with the OVRO staff suggest that much of the existing signal path could be used for Radio Science observations.

  4. Effect of dipole-quadrupole Robinson mode coupling upon the beam response to radio-frequency phase noise

    Directory of Open Access Journals (Sweden)

    R. A. Bosch

    2006-09-01

    Full Text Available In an electron storage ring, coupling between dipole and quadrupole Robinson oscillations modifies the spectrum of longitudinal beam oscillations driven by radio-frequency (rf generator phase noise. In addition to the main peak at the resonant frequency of the coupled dipole Robinson mode, another peak occurs at the resonant frequency of the coupled quadrupole mode. To describe these peaks analytically for a quadratic synchrotron potential, we include the dipole and quadrupole modes when calculating the beam response to generator noise. We thereby obtain the transfer function from generator-noise phase modulation to beam phase modulation with and without phase feedback. For Robinson-stable bunches confined in a synchrotron potential with a single minimum, the calculated transfer function agrees with measurements at the Aladdin 800-MeV electron storage ring. The transfer function is useful in evaluating phase feedback that suppresses Robinson oscillations in order to obtain quiet operation of an infrared beam line.

  5. Improvement in the accuracy of flux measurement of radio sources by exploiting an arithmetic pattern in photon bunching noise

    Science.gov (United States)

    Lieu, Richard

    2018-01-01

    A hierarchy of statistics of increasing sophistication and accuracy is proposed, to exploit an interesting and fundamental arithmetic structure in the photon bunching noise of incoherent light of large photon occupation number, with the purpose of suppressing the noise and rendering a more reliable and unbiased measurement of the light intensity. The method does not require any new hardware, rather it operates at the software level, with the help of high precision computers, to reprocess the intensity time series of the incident light to create a new series with smaller bunching noise coherence length. The ultimate accuracy improvement of this method of flux measurement is limited by the timing resolution of the detector and the photon occupation number of the beam (the higher the photon number the better the performance). The principal application is accuracy improvement in the bolometric flux measurement of a radio source.

  6. Improvement in the Accuracy of Flux Measurement of Radio Sources by Exploiting an Arithmetic Pattern in Photon Bunching Noise

    Energy Technology Data Exchange (ETDEWEB)

    Lieu, Richard [Department of Physics, University of Alabama, Huntsville, AL 35899 (United States)

    2017-07-20

    A hierarchy of statistics of increasing sophistication and accuracy is proposed to exploit an interesting and fundamental arithmetic structure in the photon bunching noise of incoherent light of large photon occupation number, with the purpose of suppressing the noise and rendering a more reliable and unbiased measurement of the light intensity. The method does not require any new hardware, rather it operates at the software level with the help of high-precision computers to reprocess the intensity time series of the incident light to create a new series with smaller bunching noise coherence length. The ultimate accuracy improvement of this method of flux measurement is limited by the timing resolution of the detector and the photon occupation number of the beam (the higher the photon number the better the performance). The principal application is accuracy improvement in the signal-limited bolometric flux measurement of a radio source.

  7. Type 2 solar radio burst with the reverse frequency drift on the background of a noise storm

    International Nuclear Information System (INIS)

    Korolev, O.S.; Fomichev, V.V.; Chertok, I.M.

    1979-01-01

    Discussed are the main peculiarities of solar radio burst of the 2nd type recorded on November, 19, 1975 in 11sup(h)02sup(m)-11sup(h)06sup(m)UT in the 45-90 MHz range. The burst considered occurred at the background of the developed noise storm with continuum radiation chearacteristic of it and narrow band. Short-term burst of the first type. The burst band drift was accompanied by the successive cessation of noise storm radiation at frequencies of 50-70 MHz. This phenomenon is interpreted as the result of the interaction between the shock wave spreading in the direction of increasing electron density, and the source of noise storm in coronal plasma. Estimated is the shock wave rate and the paremeters of coronal plasma in the direction of its spreading. A mechanism of interaction between the shock wave and the noise storm source is studied. The observed cessation of noise storm generation is explained by violation of conditions of development of instabilities, in particular, with the isotropization of electrons in the radiation source

  8. Measurement of macroscopic plasma parameters with a radio experiment: Interpretation of the quasi-thermal noise spectrum observed in the solar wind

    Science.gov (United States)

    Couturier, P.; Hoang, S.; Meyer-Vernet, N.; Steinberg, J. L.

    1983-01-01

    The ISEE-3 SBH radio receiver has provided the first systematic observations of the quasi-thermal (plasma waves) noise in the solar wind plasma. The theoretical interpretation of that noise involves the particle distribution function so that electric noise measurements with long antennas provide a fast and independent method of measuring plasma parameters: densities and temperatures of a two component (core and halo) electron distribution function have been obtained in that way. The polarization of that noise is frequency dependent and sensitive to the drift velocity of the electron population. Below the plasma frequency, there is evidence of a weak noise spectrum with spectral index -1 which is not yet accounted for by the theory. The theoretical treatment of the noise associated with the low energy (thermal) proton population shows that the moving electrical antenna radiates in the surrounding plasma by Carenkov emission which becomes predominant at the low frequencies, below about 0.1 F sub P.

  9. The Mitigation of Radio Noise from External Sources at Receiving Sites

    Science.gov (United States)

    2007-05-01

    53 3.1.7 Underground Distribution Lines...available newer models were preferred for laboratory measurements of time- stable signals and noise. 9 An ELF Engineering Model 7200B 3-Axis... communications terminal was located about 1 km from an HF and VHF receiving site. The satellite terminal was equipped with an Uninterruptible Power Supply (UPS

  10. Compressed Sensing Methods in Radio Receivers Exposed to Noise and Interference

    DEFF Research Database (Denmark)

    Pierzchlewski, Jacek

    , there is a problem of interference, which makes digitization of radio receivers even more dicult. High-order low-pass lters are needed to remove interfering signals and secure a high-quality reception. In the mid-2000s a new method of signal acquisition, called compressed sensing, emerged. Compressed sensing...... the downconverted baseband signal and interference, may be replaced by low-order lters. Additional digital signal processing is a price to pay for this feature. Hence, the signal processing is moved from the analog to the digital domain. Filtering compressed sensing, which is a new application of compressed sensing...

  11. Radio-frequency shot-noise measurement in a magnetic tunnel junction with a MgO barrier

    International Nuclear Information System (INIS)

    Rehman, Mushtaq; Park, Junghwan; Song, Woon; Chong, Yonuk; Lee, Yeonsub; Min, Byoungchul; Shin, Kyungho; Ryu, Sangwan; Khim, Zheong

    2010-01-01

    We measured the noise power of a magnetic tunnel junction in the frequency range of 710 ∼ 1200 MHz. A low-noise cryogenic HEMT amplifier was used to measure the small noise signal at a high frequency with wide bandwidth. The MgO-barrier tunnel junction showed large tunnel magnetoresistance ratio of 215% at low temperature, which indicates electronic transport through the tunnel barrier without any significant spin-flip scattering. In the bias-dependent noise measurement, however, the zero-bias shot noise was enhanced compared to the value expected from a perfect tunnel barrier or the value observed from a good Al-AlO x -Al tunnel junction. We assume that this enhanced noise comes from inelastic tunneling processes through the barrier, which may be related to the observed zero-bias anomaly in the differential resistance of the tunnel junctions. We present a simple phenomenological model for how the inelastic scattering process can enhance the zero-bias noise in a tunnel junction.

  12. Radio astronomy

    CERN Document Server

    Alder, Berni

    1975-01-01

    Methods in Computational Physics, Volume 14: Radio Astronomy is devoted to the role of the digital computer both as a control device and as a calculator in addressing problems related to galactic radio noise. This volume contains four chapters and begins with a technical description of the hardware and the special data-handling problems of using radioheliography, with an emphasis on a selection of observational results obtained with the Culgoora radioheliograph and their significance to solar physics and to astrophysics in general. The subsequent chapter examines interstellar dispersion, i

  13. Human-induced Arctic moistening.

    Science.gov (United States)

    Min, Seung-Ki; Zhang, Xuebin; Zwiers, Francis

    2008-04-25

    The Arctic and northern subpolar regions are critical for climate change. Ice-albedo feedback amplifies warming in the Arctic, and fluctuations of regional fresh water inflow to the Arctic Ocean modulate the deep ocean circulation and thus exert a strong global influence. By comparing observations to simulations from 22 coupled climate models, we find influence from anthropogenic greenhouse gases and sulfate aerosols in the space-time pattern of precipitation change over high-latitude land areas north of 55 degrees N during the second half of the 20th century. The human-induced Arctic moistening is consistent with observed increases in Arctic river discharge and freshening of Arctic water masses. This result provides new evidence that human activity has contributed to Arctic hydrological change.

  14. RADIO NOISE ADVANCES SEXUAL MATURITY

    African Journals Online (AJOL)

    ansistf-lewis

    1 Animal and Poultry Science, School of Agricultural Sciences and ... illumination per day could be enhanced, particularly during the early stages ... Cobb or 220 Ross birds placed in each pen at a stocking density of 9.2/m². ... Sixty birds per pen were randomly sampled and bulk weighed at 7, 14, 21 and 28 d of age, and all.

  15. RADIO NOISE ADVANCES SEXUAL MATURITY

    African Journals Online (AJOL)

    ansistf-lewis

    by two 11W compact warm-white fluorescent lamps located 1.8 m above the floor, giving a mean illuminance of 29 ± 2.3 lux at a height of 20 cm. All groups received the same feeding regimen: a proprietary broiler starter crumb (12.8 MJ ME /kg, 200 g crude protein/kg) to 14 d, a broiler grower pellet (12.8 MJ ME. /kg, 160 g ...

  16. Radio astronomy

    Energy Technology Data Exchange (ETDEWEB)

    Nagnibeda, V.G.

    1981-01-01

    The history of radio astronomical observations at the Astronomical Observatory of Leningrad State University is reviewed. Various facilities are described, and methods and instruments used are discussed. Some results are summarized for radio observations of the sun, including observations of local sources of solar radio emission, the absolute solar radio flux, and radio emission from filaments and prominences.

  17. The importance of Radio Quiet Zone (RQZ) for radio astronomy

    Science.gov (United States)

    Umar, Roslan; Abidin, Zamri Zainal; Ibrahim, Zainol Abidin

    2013-05-01

    Most of radio observatories are located in isolated areas. Since radio sources from the universe is very weak, astronomer need to avoid radio frequency interference (RFI) from active spectrum users and radio noise produced by human made (telecommunication, mobile phone, microwave user and many more. There are many observatories around the world are surrounded by a Radio Quiet Zone (RQZ), which is it was set up using public or state laws. A Radio Quiet Zone normally consists of two areas: an exclusive area in which totally radio emissions are forbidden, with restrictions for residents and business developments, and a larger (radius up to 100 km above) coordination area where the power of radio transmission limits to threshold levels. Geographical Information System (GIS) can be used as a powerful tool in mapping large areas with varying RQZ profiles. In this paper, we report the initial testing of the usage of this system in order to identify the areas were suitable for Radio Quiet Zone. Among the important parameters used to develop the database for our GIS are population density, information on TV and telecommunication (mobile phones) transmitters, road networks (highway), and contour shielding. We will also use other information gathered from on-site RFI level measurements on selected 'best' areas generated by the GIS. The intention is to find the best site for the purpose of establishing first radio quiet zones for radio telescope in Malaysia.

  18. Noise suppression by noise

    OpenAIRE

    Vilar, J. M. G. (José M. G.), 1972-; Rubí Capaceti, José Miguel

    2001-01-01

    We have analyzed the interplay between an externally added noise and the intrinsic noise of systems that relax fast towards a stationary state, and found that increasing the intensity of the external noise can reduce the total noise of the system. We have established a general criterion for the appearance of this phenomenon and discussed two examples in detail.

  19. Radio stars

    International Nuclear Information System (INIS)

    Hjellming, R.M.

    1976-01-01

    Any discussion of the radio emission from stars should begin by emphasizing certain unique problems. First of all, one must clarify a semantic confusion introduced into radio astronomy in the late 1950's when most new radio sources were described as radio stars. All of these early 'radio stars' were eventually identified with other galactic and extra-galactic objects. The study of true radio stars, where the radio emission is produced in the atmosphere of a star, began only in the 1960's. Most of the work on the subject has, in fact, been carried out in only the last few years. Because the real information about radio stars is quite new, it is not surprising that major aspects of the subject are not at all understood. For this reason this paper is organized mainly around three questions: what is the available observational information; what physical processes seem to be involved; and what working hypotheses look potentially fruitful. (Auth.)

  20. Radio and line transmission 2

    CERN Document Server

    Roddy, Dermot

    2013-01-01

    Radio and Line Transmission, Volume 2 gives a detailed treatment of the subject as well as an introduction to additional advanced subject matter. Organized into 14 chapters, this book begins by explaining the radio wave propagation, signal frequencies, and bandwidth. Subsequent chapters describe the transmission lines and cables; the aerials; tuned and coupled circuits; bipolar transistor amplifiers; field-effect transistors and circuits; thermionic valve amplifiers; LC oscillators; the diode detectors and modulators; and the superheterodyne receiver. Other chapters explore noise and interfere

  1. Wideband Low Noise Amplifiers Exploiting Thermal Noise Cancellation

    NARCIS (Netherlands)

    Bruccoleri, F.; Klumperink, Eric A.M.; Nauta, Bram

    2005-01-01

    Low Noise Amplifiers (LNAs) are commonly used to amplify signals that are too weak for direct processing for example in radio or cable receivers. Traditionally, low noise amplifiers are implemented via tuned amplifiers, exploiting inductors and capacitors in resonating LC-circuits. This can render

  2. Performance Evaluation of Relay Selection Schemes in Beacon-Assisted Dual-Hop Cognitive Radio Wireless Sensor Networks under Impact of Hardware Noises.

    Science.gov (United States)

    Hieu, Tran Dinh; Duy, Tran Trung; Dung, Le The; Choi, Seong Gon

    2018-06-05

    To solve the problem of energy constraints and spectrum scarcity for cognitive radio wireless sensor networks (CR-WSNs), an underlay decode-and-forward relaying scheme is considered, where the energy constrained secondary source and relay nodes are capable of harvesting energy from a multi-antenna power beacon (PB) and using that harvested energy to forward the source information to the destination. Based on the time switching receiver architecture, three relaying protocols, namely, hybrid partial relay selection (H-PRS), conventional opportunistic relay selection (C-ORS), and best opportunistic relay selection (B-ORS) protocols are considered to enhance the end-to-end performance under the joint impact of maximal interference constraint and transceiver hardware impairments. For performance evaluation and comparison, we derive the exact and asymptotic closed-form expressions of outage probability (OP) and throughput (TP) to provide significant insights into the impact of our proposed protocols on the system performance over Rayleigh fading channel. Finally, simulation results validate the theoretical results.

  3. Tools of radio astronomy

    CERN Document Server

    Wilson, Thomas L; Hüttemeister, Susanne

    2013-01-01

    This 6th edition of “Tools of Radio Astronomy”, the most used introductory text in radio astronomy, has been revised to reflect the current state of this important branch of astronomy. This includes the use of satellites, low radio frequencies, the millimeter/sub-mm universe, the Cosmic Microwave Background and the increased importance of mm/sub-mm dust emission. Several derivations and presentations of technical aspects of radio astronomy and receivers, such as receiver noise, the Hertz dipole and  beam forming have been updated, expanded, re-worked or complemented by alternative derivations. These reflect advances in technology. The wider bandwidths of the Jansky-VLA and long wave arrays such as LOFAR and mm/sub-mm arrays such as ALMA required an expansion of the discussion of interferometers and aperture synthesis. Developments in data reduction algorithms have been included. As a result of the large amount of data collected in the past 20 years, the discussion of solar system radio astronomy, dust em...

  4. Radio stars

    International Nuclear Information System (INIS)

    Hjellming, R.M.; Gibson, D.M.

    1985-01-01

    Studies of stellar radio emission became an important field of research in the 1970's and have now expanded to become a major area of radio astronomy with the advent of new instruments such as the Very Large Array in New Mexico and transcontinental telescope arrays. This volume contains papers from the workshop on stellar continuum radio astronomy held in Boulder, Colorado, and is the first book on the rapidly expanding field of radio emission from stars and stellar systems. Subjects covered include the observational and theoretical aspects of stellar winds from both hot and cool stars, radio flares from active double star systems and red dwarf stars, bipolar flows from star-forming regions, and the radio emission from X-ray binaries. (orig.)

  5. Noise storm coordinated observations

    International Nuclear Information System (INIS)

    Elgaroey, Oe.; Tlamicha, A.

    1983-01-01

    The usually accepted bipolar model of noise storm centers is irrelevant for the present observations. An alternative model has been proposed in which the different sources of a noise storm center are located in different flux tubes connecting active regions with their surroundings. Radio emission is observed from the wide, descending branch of the flux tubes, opposite to the flaring site. The relation between the sense of circular polarization of the radio emission and the magnetic polarity, has been more precisely defined. The radiation is in the ordinary mode with respect to the underlying large scale photospheric magnetic polarity. Thus the ''irregular'' polarity of noice storm center ''B'' is explained. As regards center ''C'', one should note that although the observed radio emission is polarized in the ordinary mode with respect to the leading spot of region HR 17653, center ''C'' is not situated in flux tubes originating from the leading part of this region according to the proposed model. Rather, the radio sources are located in the wide and descending part of flux tubes connecting a large, quiet area of south magnetic polarity with the following part of the region HR 17653 (of north magnetic polarity). Thus it is the polarity of the extended area which determines the polarization of the radio emission. The observed polarization should result rather from the emission process than from complicated conditions of propagation for the radio waves

  6. Hybrid cognitive engine for radio systems adaptation

    KAUST Repository

    Alqerm, Ismail; Shihada, Basem

    2017-01-01

    of our hybrid engine is validated using software defined radios implementation and simulation in multi-carrier environment. The system throughput, signal to noise and interference ratio, and packet error rate are obtained and compared with other schemes

  7. Propagation engineering in radio links design

    CERN Document Server

    Ghasemi, Abdollah; Ghasemi, Farshid

    2013-01-01

    Propagation Engineering in Radio Link Design covers the basic principles of radiowaves propagation in a practical manner.  This fundamental understanding enables the readers to design radio links efficiently. This book elaborates on new achievements as well as recently developed propagation models.  This is in addition to a comprehensive overview of fundamentals of propagation in various scenarios. It examines theoretical calculations, approaches and applied procedures needed for radio links design. The authors study and analysis of the main propagation phenomena and its mechanisms based on the recommendations of International Telecommunications Union, (ITU). The book has been organized in 9 chapters and examines the role of antennas and passive reflectors in radio services, propagation mechanisms related to radar, satellite, short distance, broadcasting and trans-horizon radio links, with two chapters devoted to radio noise and main  parameters of radio link design. The book presents some 278 illustration...

  8. Human-induced geomorphic change across environmental gradients

    Science.gov (United States)

    Vanacker, V.; Molina, A.; Bellin, N.; Christl, M.

    2016-12-01

    Human-induced land cover changes are causing important adverse effects on the ecological services rendered by mountain ecosystems, and the number of case-studies of the impact of humans on soil erosion and sediment yield has mounted rapidly. Anthropogenic disturbance of natural vegetation can profoundly alter the physical, chemical and biological processes within soils. Rapid removal of topsoil during intense farming can result in an imbalance between soil production through chemical weathering and physical soil erosion, with direct implications on nutrient cycling, soil fertility and agricultural production. In this study, we present a conceptual model for assessing human-induced erosion for a wide variety of environmental settings and pose that human-induced geomorphic change cannot be assessed solely based on modern erosion rates as natural or baseline erosion rates can be important in e.g. mountainous terrain. As such, we assess the vulnerability of a given ecosystem to human-induced land cover change by quantifying the change in catchment-wide erosion rates resulting from anthropogenic changes in vegetation cover. Human-induced erosion is here approximated by the ratio of the total specific sediment yield to the natural erosional mass flux, and is dimensionless. The conceptual model is applied to three contrasting environmental settings where data on soil production, physical soil erosion and long-term denudation are available: the tropical Andes, subtropical southern Brazil, and semi-arid Spanish Cordillera. The magnitude of human-induced geomorphic change strongly differs between the three regions. The data suggest that the sensitivity to human-induced erosion is ecosystem dependent, and related to soil erosivity and potential vegetation cover disturbances as a result of human impact. It may therefore be expected that the potential for erosion regulation is larger in well-vegetated ecosystem where strong differences may exist in vegetation cover between

  9. Solar Radio

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Scientists monitor the structure of the solar corona, the outer most regions of the Sun's atmosphere, using radio waves (100?s of MHz to 10?s of GHz). Variations in...

  10. Radio astronomy

    International Nuclear Information System (INIS)

    Parijskij, Y.N.; Gossachinskij, I.V.; Zuckerman, B.; Khersonsky, V.K.; Pustilnik, S.; Robinson, B.J.

    1976-01-01

    A critical review of major developments and discoveries in the field of radioastronomy during the period 1973-1975 is presented. The report is presented under the following headings:(1) Continuum radiation from the Galaxy; (2) Neutral hydrogen, 21 cm (galactic and extragalactic) and recombination lines; (3) Radioastronomy investigations of interstellar molecules; (4) Extragalactic radio astronomy and (6) Development in radio astronomy instruments. (B.R.H.)

  11. Some Ethical Concerns About Human Induced Pluripotent Stem Cells.

    Science.gov (United States)

    Zheng, Yue Liang

    2016-10-01

    Human induced pluripotent stem cells can be obtained from somatic cells, and their derivation does not require destruction of embryos, thus avoiding ethical problems arising from the destruction of human embryos. This type of stem cell may provide an important tool for stem cell therapy, but it also results in some ethical concerns. It is likely that abnormal reprogramming occurs in the induction of human induced pluripotent stem cells, and that the stem cells generate tumors in the process of stem cell therapy. Human induced pluripotent stem cells should not be used to clone human beings, to produce human germ cells, nor to make human embryos. Informed consent should be obtained from patients in stem cell therapy.

  12. Real-Time Measurements for Adaptive and Cognitive Radio Systems

    Directory of Open Access Journals (Sweden)

    Hüseyin Arslan

    2009-01-01

    Full Text Available Adaptive and cognitive radios (CR have been becoming popular for optimizing mobile radio system transmission and reception. One of the most important elements of the adaptive radio and CR concepts is the ability to measure, sense, learn about, and be aware of parameters related to the radio channel characteristics, availability of spectrum and power, interference and noise temperature, operational environment of radio, user requirements and applications, available networks and infrastructures, local policies, other operating restrictions, and so on. This paper discusses some of the important measurement parameters for enabling adaptive radio and CR systems along with their relationships and impacts on the performance including relevant challenges.

  13. Synthesis imaging in radio astronomy

    International Nuclear Information System (INIS)

    Perley, R.A.; Schwab, F.R.; Bridle, A.H.

    1989-01-01

    Recent advances in techniques and instrumentation for radio synthesis imaging in astronomy are discussed in a collection of review essays. Topics addressed include coherence in radio astronomy, the interferometer in practice, primary antenna elements, cross correlators, calibration and editing, sensitivity, deconvolution, self-calibration, error recognition, and image analysis. Consideration is given to wide-field imaging (bandwidth and time-average smearing, noncoplanar arrays, and mosaicking), high-dynamic-range imaging, spectral-line imaging, VLBI, solar imaging with a synthesis telescope, synthesis imaging of spatially coherent objects, noise in images of very bright sources, synthesis observing strategies, and the design of aperture-synthesis arrays

  14. Origin of solar radio waves

    International Nuclear Information System (INIS)

    Olmr, J.

    1977-01-01

    Solar radiowave radiation amounts to about 10 -7 of the total solar radiation. The solar atmosphere emits radiation of different wavelengths from a fraction of nanometer to kilometer waves. The solar radiowaves are of thermal origin and except for neutral hydrogen emission and solid body radio emission their emission always results from free electrons. The radiowave radiation active components were classified in several types, such as noise storms, flashes, flares, continuum, and flashes lasting for several minutes. The respective types are discussed and their origins shown. The mechanisms are described permitting the formation of radio waves of nonthermal origin, i.e., plasma oscillations, gyromagnetic emission, synchrotron and Cherenkov radiations. (J.P.)

  15. Global Assessment of Human-induced Soil Degradation (GLASOD)

    NARCIS (Netherlands)

    Oldeman, L.R.; Hakkeling, R.T.A.; Sombroek, W.G.; Batjes, N.H.

    2014-01-01

    The GLASOD project (1987-1990) has produced a world map of human-induced soil degradation. Data were complied in cooperation with a large number of soil scientists throughout the world, using uniform Guidelines and international correlation. The status of soil degradation was mapped within loosely

  16. Radio Frequency Interference: The Study of Rain Effect on Radio Signal Attenuation

    International Nuclear Information System (INIS)

    Roslan Umar; Roslan Umar; Shahirah Syafa Sulan; Atiq Wahidah Azlan; Zainol Abidin Ibrahim

    2015-01-01

    The intensity of radio waves received by radio telescopes is always not subject to human control. In the millimetre band, the propagation of the electromagnetic waves is severely affected by rain rate, dust particle size and drop size in the terms of attenuation, noise and depolarization. At the frequency above 10 GHz, the absorption and scattering by rain cause a reduction in the transmitted signal amplitude which will lead to the reducing of the availability, reliability and performance on the communications link. In this study, the rain effect on radio signal has been investigated. Spectrum analyzer and weather stations were used to obtain the RFI level and rain rate data respectively. The radio frequency interference (RFI) pattern due to rain factor was determined. This will benefit radio astronomer in managing sites for radio observation for radio astronomy purposes. (author)

  17. Distributed Robust Power Minimization for the Downlink of Multi-Cloud Radio Access Networks

    KAUST Repository

    Dhifallah, Oussama Najeeb; Dahrouj, Hayssam; Al-Naffouri, Tareq Y.; Alouini, Mohamed-Slim

    2017-01-01

    Conventional cloud radio access networks assume single cloud processing and treat inter-cloud interference as background noise. This paper considers the downlink of a multi-cloud radio access network (CRAN) where each cloud is connected to several

  18. Differentiation of human-induced pluripotent stem cells into insulin-producing clusters.

    Science.gov (United States)

    Shaer, Anahita; Azarpira, Negar; Vahdati, Akbar; Karimi, Mohammad Hosein; Shariati, Mehrdad

    2015-02-01

    In diabetes mellitus type 1, beta cells are mostly destroyed; while in diabetes mellitus type 2, beta cells are reduced by 40% to 60%. We hope that soon, stem cells can be used in diabetes therapy via pancreatic beta cell replacement. Induced pluripotent stem cells are a kind of stem cell taken from an adult somatic cell by "stimulating" certain genes. These induced pluripotent stem cells may be a promising source of cell therapy. This study sought to produce isletlike clusters of insulin-producing cells taken from induced pluripotent stem cells. A human-induced pluripotent stem cell line was induced into isletlike clusters via a 4-step protocol, by adding insulin, transferrin, and selenium (ITS), N2, B27, fibroblast growth factor, and nicotinamide. During differentiation, expression of pancreatic β-cell genes was evaluated by reverse transcriptase-polymerase chain reaction; the morphologic changes of induced pluripotent stem cells toward isletlike clusters were observed by a light microscope. Dithizone staining was used to stain these isletlike clusters. Insulin produced by these clusters was evaluated by radio immunosorbent assay, and the secretion capacity was analyzed with a glucose challenge test. Differentiation was evaluated by analyzing the morphology, dithizone staining, real-time quantitative polymerase chain reaction, and immunocytochemistry. Gene expression of insulin, glucagon, PDX1, NGN3, PAX4, PAX6, NKX6.1, KIR6.2, and GLUT2 were documented by analyzing real-time quantitative polymerase chain reaction. Dithizone-stained cellular clusters were observed after 23 days. The isletlike clusters significantly produced insulin. The isletlike clusters could increase insulin secretion after a glucose challenge test. This work provides a model for studying the differentiation of human-induced pluripotent stem cells to insulin-producing cells.

  19. Evaluation of human-induced vibration of continuous footbridges

    OpenAIRE

    El-Robaa Ahmed; Gaawan Sameh; Malek Charles

    2015-01-01

    With the development of construction materials and the introduction of high strength steel and concrete, the human-induced vibration became a dominant criterion for the design of pedestrian bridges. Currently, longer spans and lightweight bridges have been comprised in most of design trends. This leads to lower the natural frequencies of the system which have a great effect on the dynamic performance of bridges subjected to human activities. Although the design of steel footbridges could reac...

  20. The Economics and Ethics of Human Induced Climate Change

    OpenAIRE

    Spash, Clive L.; Gattringer, Clemens

    2016-01-01

    Human induced climate change poses a series of ethical challenges to the current political economy, although it has often be regarded by economists as only an ethical issue for those concerned about future generations. The central debate in economics has then concerned the rate at which future costs and benefits should be discounted. Indeed the full range of ethical aspects of climate change are rarely even discussed. Despite recent high profile and lengthy academic papers on t...

  1. Behavioural responses to human-induced environmental change.

    Science.gov (United States)

    Tuomainen, Ulla; Candolin, Ulrika

    2011-08-01

    The initial response of individuals to human-induced environmental change is often behavioural. This can improve the performance of individuals under sudden, large-scale perturbations and maintain viable populations. The response can also give additional time for genetic changes to arise and, hence, facilitate adaptation to new conditions. On the other hand, maladaptive responses, which reduce individual fitness, may occur when individuals encounter conditions that the population has not experienced during its evolutionary history, which can decrease population viability. A growing number of studies find human disturbances to induce behavioural responses, both directly and by altering factors that influence fitness. Common causes of behavioural responses are changes in the transmission of information, the concentration of endocrine disrupters, the availability of resources, the possibility of dispersal, and the abundance of interacting species. Frequent responses are alterations in habitat choice, movements, foraging, social behaviour and reproductive behaviour. Behavioural responses depend on the genetically determined reaction norm of the individuals, which evolves over generations. Populations first respond with individual behavioural plasticity, whereafter changes may arise through innovations and the social transmission of behavioural patterns within and across generations, and, finally, by evolution of the behavioural response over generations. Only a restricted number of species show behavioural adaptations that make them thrive in severely disturbed environments. Hence, rapid human-induced disturbances often decrease the diversity of native species, while facilitating the spread of invasive species with highly plastic behaviours. Consequently, behavioural responses to human-induced environmental change can have profound effects on the distribution, adaptation, speciation and extinction of populations and, hence, on biodiversity. A better understanding of

  2. The Radio JOVE Project - Shoestring Radio Astronomy

    Science.gov (United States)

    Thieman, J.; Flagg, R.; Greenman, W.; Higgins, C.; Reyes, F.; Sky, J.

    2010-01-01

    Radio JOVE is an education and outreach project intended to give students and other interested individuals hands-on experience in learning radio astronomy. They can do this through building a radio telescope from a relatively inexpensive kit that includes the parts for a receiver and an antenna as well as software for a computer chart recorder emulator (Radio Skypipe) and other reference materials

  3. Agent-based simulation for human-induced hazard analysis.

    Science.gov (United States)

    Bulleit, William M; Drewek, Matthew W

    2011-02-01

    Terrorism could be treated as a hazard for design purposes. For instance, the terrorist hazard could be analyzed in a manner similar to the way that seismic hazard is handled. No matter how terrorism is dealt with in the design of systems, the need for predictions of the frequency and magnitude of the hazard will be required. And, if the human-induced hazard is to be designed for in a manner analogous to natural hazards, then the predictions should be probabilistic in nature. The model described in this article is a prototype model that used agent-based modeling (ABM) to analyze terrorist attacks. The basic approach in this article of using ABM to model human-induced hazards has been preliminarily validated in the sense that the attack magnitudes seem to be power-law distributed and attacks occur mostly in regions where high levels of wealth pass through, such as transit routes and markets. The model developed in this study indicates that ABM is a viable approach to modeling socioeconomic-based infrastructure systems for engineering design to deal with human-induced hazards. © 2010 Society for Risk Analysis.

  4. Space Telecommunications Radio System STRS Cognitive Radio

    Science.gov (United States)

    Briones, Janette C.; Handler, Louis M.

    2013-01-01

    Radios today are evolving from awareness toward cognition. A software defined radio (SDR) provides the most capability for integrating autonomic decision making ability and allows the incremental evolution toward a cognitive radio. This cognitive radio technology will impact NASA space communications in areas such as spectrum utilization, interoperability, network operations, and radio resource management over a wide range of operating conditions. NASAs cognitive radio will build upon the infrastructure being developed by Space Telecommunication Radio System (STRS) SDR technology. This paper explores the feasibility of inserting cognitive capabilities in the NASA STRS architecture and the interfaces between the cognitive engine and the STRS radio. The STRS architecture defines methods that can inform the cognitive engine about the radio environment so that the cognitive engine can learn autonomously from experience, and take appropriate actions to adapt the radio operating characteristics and optimize performance.

  5. Calibration of an audio frequency noise generator

    DEFF Research Database (Denmark)

    Diamond, Joseph M.

    1966-01-01

    a noise bandwidth Bn = π/2 × (3dB bandwidth). To apply this method to low audio frequencies, the noise bandwidth of the low Q parallel resonant circuit has been found, including the effects of both series and parallel damping. The method has been used to calibrate a General Radio 1390-B noise generator...... it is used for measurement purposes. The spectral density of a noise source may be found by measuring its rms output over a known noise bandwidth. Such a bandwidth may be provided by a passive filter using accurately known elements. For example, the parallel resonant circuit with purely parallel damping has...

  6. Hybrid cognitive engine for radio systems adaptation

    KAUST Repository

    Alqerm, Ismail

    2017-07-20

    Network efficiency and proper utilization of its resources are essential requirements to operate wireless networks in an optimal fashion. Cognitive radio aims to fulfill these requirements by exploiting artificial intelligence techniques to create an entity called cognitive engine. Cognitive engine exploits awareness about the surrounding radio environment to optimize the use of radio resources and adapt relevant transmission parameters. In this paper, we propose a hybrid cognitive engine that employs Case Based Reasoning (CBR) and Decision Trees (DTs) to perform radio adaptation in multi-carriers wireless networks. The engine complexity is reduced by employing DTs to improve the indexing methodology used in CBR cases retrieval. The performance of our hybrid engine is validated using software defined radios implementation and simulation in multi-carrier environment. The system throughput, signal to noise and interference ratio, and packet error rate are obtained and compared with other schemes in different scenarios.

  7. Optical detection of radio waves through a nanomechanical transducer

    DEFF Research Database (Denmark)

    Bagci, T.; Simonsen, A.; Schmid, Silvan

    2014-01-01

    Low-loss transmission and sensitive recovery of weak radio-frequency and microwave signals is a ubiquitous challenge, crucial in radio astronomy, medical imaging, navigation, and classical and quantum communication. Efficient up-conversion of radio-frequency signals to an optical carrier would...... strong coupling between the voltage fluctuations in a radio-frequency resonance circuit and the membrane's displacement, which is simultaneously coupled to light reflected off its surface. The radio-frequency signals are detected as an optical phase shift with quantum-limited sensitivity....... The corresponding half-wave voltage is in the microvolt range, orders of magnitude less than that of standard optical modulators. The noise of the transducer--beyond the measured 800 pV Hz-1/2 Johnson noise of the resonant circuit--consists of the quantum noise of light and thermal fluctuations of the membrane...

  8. Noise Pollution

    Science.gov (United States)

    ... Regulated by EPA EPA or a designated Federal agency regulates noise sources, such as rail and motor carriers, low noise emission products, construction equipment, transport equipment, trucks, motorcycles, and the labeling of hearing ...

  9. Community noise

    Science.gov (United States)

    Bragdon, C. R.

    Airport and community land use planning as they relate to airport noise reduction are discussed. Legislation, community relations, and the physiological effect of airport noise are considered. Noise at the Logan, Los Angeles, and Minneapolis/St. Paul airports is discussed.

  10. The radio universe

    International Nuclear Information System (INIS)

    Worvill, R.

    1977-01-01

    Elementary description of the development of radioastronomy, radio waves from the sun and planets, the use of radio telescopes and the detection of nebulae, supernova, radio galaxies and quasars is presented. A brief glossary of terms is included. (UK)

  11. Magnetospheric radio sounding

    International Nuclear Information System (INIS)

    Ondoh, Tadanori; Nakamura, Yoshikatsu; Koseki, Teruo; Watanabe, Sigeaki; Murakami, Toshimitsu

    1977-01-01

    Radio sounding of the plasmapause from a geostationary satellite has been investigated to observe time variations of the plasmapause structure and effects of the plasma convection. In the equatorial plane, the plasmapause is located, on the average, at 4 R sub(E) (R sub(E); Earth radius), and the plasma density drops outwards from 10 2 -10 3 /cm 3 to 1-10/cm 3 in the plasmapause width of about 600 km. Plasmagrams showing a relation between the virtual range and sounding frequencies are computed by ray tracing of LF-VLF waves transmitted from a geostationary satellite, using model distributions of the electron density in the vicinity of the plasmapause. The general features of the plasmagrams are similar to the topside ionograms. The plasmagram has no penetration frequency such as f 0 F 2 , but the virtual range of the plasmagram increases rapidly with frequency above 100 kHz, since the distance between a satellite and wave reflection point increases rapidly with increasing the electron density inside the plasmapause. The plasmapause sounder on a geostationary satellite has been designed by taking account of an average propagation distance of 2 x 2.6 R sub(E) between a satellite (6.6 R sub(E)) and the plasmapause (4.0 R sub(E)), background noise, range resolution, power consumption, and receiver S/N of 10 dB. The 13-bit Barker coded pulses of baud length of 0.5 msec should be transmitted in direction parallel to the orbital plane at frequencies for 10 kHz-2MHz in a pulse interval of 0.5 sec. The transmitter peak power of 70 watts and 700 watts are required respectively in geomagnetically quiet and disturbed (strong nonthermal continuum emissions) conditions for a 400 meter cylindrical dipole of 1.2 cm diameter on the geostationary satellite. This technique will open new area of radio sounding in the magnetosphere. (auth.)

  12. Laser Noise and its Impact on the Performance of Intensity-Modulation with Direct-Detection Analog Photonic Links

    National Research Council Canada - National Science Library

    Urick, Vincent J; Devgan, Preetpaul S; McKinney, Jason D; Dexter, James L

    2007-01-01

    The equations for radio-frequency gain, radio-frequency noise figure, compression dynamic range and spurious-free dynamic range are derived for an analog photonic link employing intensity modulation and direct detection...

  13. Using Human Induced Pluripotent Stem Cells to Model Skeletal Diseases.

    Science.gov (United States)

    Barruet, Emilie; Hsiao, Edward C

    2016-01-01

    Musculoskeletal disorders affecting the bones and joints are major health problems among children and adults. Major challenges such as the genetic origins or poor diagnostics of severe skeletal disease hinder our understanding of human skeletal diseases. The recent advent of human induced pluripotent stem cells (human iPS cells) provides an unparalleled opportunity to create human-specific models of human skeletal diseases. iPS cells have the ability to self-renew, allowing us to obtain large amounts of starting material, and have the potential to differentiate into any cell types in the body. In addition, they can carry one or more mutations responsible for the disease of interest or be genetically corrected to create isogenic controls. Our work has focused on modeling rare musculoskeletal disorders including fibrodysplasia ossificans progressive (FOP), a congenital disease of increased heterotopic ossification. In this review, we will discuss our experiences and protocols differentiating human iPS cells toward the osteogenic lineage and their application to model skeletal diseases. A number of critical challenges and exciting new approaches are also discussed, which will allow the skeletal biology field to harness the potential of human iPS cells as a critical model system for understanding diseases of abnormal skeletal formation and bone regeneration.

  14. Evaluation of human-induced vibration of continuous footbridges

    Directory of Open Access Journals (Sweden)

    El-Robaa Ahmed

    2015-01-01

    Full Text Available With the development of construction materials and the introduction of high strength steel and concrete, the human-induced vibration became a dominant criterion for the design of pedestrian bridges. Currently, longer spans and lightweight bridges have been comprised in most of design trends. This leads to lower the natural frequencies of the system which have a great effect on the dynamic performance of bridges subjected to human activities. Although the design of steel footbridges could reach the optimum level of design in terms of strength criterion, it might not reach the acceptance level for vibration condition. This will enforce the designer to choose section profiles with higher inertia to enhance stiffness of the whole system. This paper presents an overall assessment for floor vibration problem due to pedestrian induced vertical forces on continuous composite footbridges. The footfall method presented by concrete centre “CCIP-016” is adopted in this study to evaluate the response factor and acceleration of pedestrian bridges using a FEA software package “Robot Structural Analysis”.

  15. Generation of functional podocytes from human induced pluripotent stem cells

    Directory of Open Access Journals (Sweden)

    Osele Ciampi

    2016-07-01

    Full Text Available Generating human podocytes in vitro could offer a unique opportunity to study human diseases. Here, we describe a simple and efficient protocol for obtaining functional podocytes in vitro from human induced pluripotent stem cells. Cells were exposed to a three-step protocol, which induced their differentiation into intermediate mesoderm, then into nephron progenitors and, finally, into mature podocytes. After differentiation, cells expressed the main podocyte markers, such as synaptopodin, WT1, α-Actinin-4, P-cadherin and nephrin at the protein and mRNA level, and showed the low proliferation rate typical of mature podocytes. Exposure to Angiotensin II significantly decreased the expression of podocyte genes and cells underwent cytoskeleton rearrangement. Cells were able to internalize albumin and self-assembled into chimeric 3D structures in combination with dissociated embryonic mouse kidney cells. Overall, these findings demonstrate the establishment of a robust protocol that, mimicking developmental stages, makes it possible to derive functional podocytes in vitro.

  16. Impact of cognitive radio on radio astronomy

    NARCIS (Netherlands)

    Bentum, Marinus Jan; Boonstra, A.J.; Baan, W.A.

    2010-01-01

    The introduction of new communication techniques requires an increase in the efficiency of spectrum usage. Cognitive radio is one of the new techniques that fosters spectrum efficiency by using unoccupied frequency spectrum for communications. However, cognitive radio will increase the transmission

  17. Microtubule Abnormalities Underlying Gulf War Illness in Neurons from Human-Induced Pluripotent Cells

    Science.gov (United States)

    2016-09-01

    cells derived from human induced pluripotent stem cells (hiPSCs), originating from GW...AWARD NUMBER: W81XWH-15-1-0433 TITLE: Microtubule Abnormalities Underlying Gulf War Illness in Neurons from Human- Induced Pluripotent Cells ...A simple blood sample is taken from the soldier, and then transduced, using reliable established methods , to make the cells pluripotent .

  18. Fast Radio Bursts

    Indian Academy of Sciences (India)

    Akshaya Rane

    2017-09-12

    ) which were first discovered a decade ago. Following an introduction to radio transients in general, including pulsars and rotating radio transients, we discuss the discovery of FRBs. We then discuss FRB follow-up ...

  19. La radio digital

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Cortés S.

    2015-01-01

    Full Text Available La radio digital es un producto de la llamada convergencia digital. Las nuevas tecnologías interconectadas permiten la aparición de nuevos modos de audiencia y la implementación de herramientas versátiles. Habla del problema de los estándares, de la radio satelital, la radio digital terrestre, las radios internacionales, la interactividad.

  20. Commercial Radio as Communication.

    Science.gov (United States)

    Rothenbuhler, Eric W.

    1996-01-01

    Compares the day-to-day work routines of commercial radio with the principles of a theoretical communication model. Illuminates peculiarities of the conduct of communication by commercial radio. Discusses the application of theoretical models to the evaluation of practicing institutions. Offers assessments of commercial radio deriving from…

  1. Drone noise

    Science.gov (United States)

    Tinney, Charles; Sirohi, Jayant; University of Texas at Austin Team

    2017-11-01

    A basic understanding of the noise produced by single and multirotor drones operating at static thrust conditions is presented. This work acts as an extension to previous efforts conducted at The University of Texas at Austin (Tinney et al. 2017, AHS Forum 73). Propeller diameters ranging from 8 inch to 12 inch are examined for configurations comprising an isolated rotor, a quadcopter configuration and a hexacopter configuration, and with a constant drone pitch of 2.25. An azimuthal array of half-inch microphones, placed between 2 and 3 hub-center diameters from the drone center, are used to assess the acoustic near-field. Thrust levels, acquired using a six degree-of-freedom load cell, are then used to correlate acoustic noise levels to aerodynamic performance for each drone configuration. The findings reveal a nearly logarithmic increase in noise with increasing thrust. However, for the same thrust condition, considerable noise reduction is achieved by increasing the number of propeller blades thereby reducing the blade passage frequency and both the thickness and loading noise sources that accompany it.

  2. Thalidomide induces apoptosis in undifferentiated human induced pluripotent stem cells.

    Science.gov (United States)

    Tachikawa, Saoko; Nishimura, Toshinobu; Nakauchi, Hiromitsu; Ohnuma, Kiyoshi

    2017-10-01

    Thalidomide, which was formerly available commercially to control the symptoms of morning sickness, is a strong teratogen that causes fetal abnormalities. However, the mechanism of thalidomide teratogenicity is not fully understood; thalidomide toxicity is not apparent in rodents, and the use of human embryos is ethically and technically untenable. In this study, we designed an experimental system featuring human-induced pluripotent stem cells (hiPSCs) to investigate the effects of thalidomide. These cells exhibit the same characteristics as those of epiblasts originating from implanted fertilized ova, which give rise to the fetus. Therefore, theoretically, thalidomide exposure during hiPSC differentiation is equivalent to that in the human fetus. We examined the effects of thalidomide on undifferentiated hiPSCs and early-differentiated hiPSCs cultured in media containing bone morphogenetic protein-4, which correspond, respectively, to epiblast (future fetus) and trophoblast (future extra-embryonic tissue). We found that only the number of undifferentiated cells was reduced. In undifferentiated cells, application of thalidomide increased the number of apoptotic and dead cells at day 2 but not day 4. Application of thalidomide did not affect the cell cycle. Furthermore, immunostaining and flow cytometric analysis revealed that thalidomide exposure had no effect on the expression of specific markers of undifferentiated and early trophectodermal differentiated cells. These results suggest that the effect of thalidomide was successfully detected in our experimental system and that thalidomide eliminated a subpopulation of undifferentiated hiPSCs. This study may help to elucidate the mechanisms underlying thalidomide teratogenicity and reveal potential strategies for safely prescribing this drug to pregnant women.

  3. Human induced pluripotent stem cells on autologous feeders.

    Directory of Open Access Journals (Sweden)

    Kazutoshi Takahashi

    Full Text Available BACKGROUND: For therapeutic usage of induced Pluripotent Stem (iPS cells, to accomplish xeno-free culture is critical. Previous reports have shown that human embryonic stem (ES cells can be maintained in feeder-free condition. However, absence of feeder cells can be a hostile environment for pluripotent cells and often results in karyotype abnormalities. Instead of animal feeders, human fibroblasts can be used as feeder cells of human ES cells. However, one still has to be concerned about the existence of unidentified pathogens, such as viruses and prions in these non-autologous feeders. METHODOLOGY/PRINCIPAL FINDINGS: This report demonstrates that human induced Pluripotent Stem (iPS cells can be established and maintained on isogenic parental feeder cells. We tested four independent human skin fibroblasts for the potential to maintain self-renewal of iPS cells. All the fibroblasts tested, as well as their conditioned medium, were capable of maintaining the undifferentiated state and normal karyotypes of iPS cells. Furthermore, human iPS cells can be generated on isogenic parental fibroblasts as feeders. These iPS cells carried on proliferation over 19 passages with undifferentiated morphologies. They expressed undifferentiated pluripotent cell markers, and could differentiate into all three germ layers via embryoid body and teratoma formation. CONCLUSIONS/SIGNIFICANCE: These results suggest that autologous fibroblasts can be not only a source for iPS cells but also be feeder layers. Our results provide a possibility to solve the dilemma by using isogenic fibroblasts as feeder layers of iPS cells. This is an important step toward the establishment of clinical grade iPS cells.

  4. Possible mechanism of solar noise storm generation in meter wavelength

    International Nuclear Information System (INIS)

    Genkin, L.G.; Erukhimov, L.M.; Levin, B.N.

    1989-01-01

    Fluctuation plasma mechanism of noise storm generation is proposed. The sporadic formation of density irregularities in plasma (Langmuir) turbulence region is shown to be the result of thermal stratification of plasma. The noise storm type 1 bursts in their typical parameters are like radio emission due to plasma turbulence conversion on this structures

  5. Ham radio for dummies

    CERN Document Server

    Silver, H Ward

    2013-01-01

    An ideal first step for learning about ham radio Beyond operating wirelessly, today's ham radio operators can transmit data and pictures; use the Internet, laser, and microwave transmitters; and travel to places high and low to make contact. This hands-on beginner guide reflects the operational and technical changes to amateur radio over the past decade and provides you with updated licensing requirements and information, changes in digital communication (such as the Internet, social media, and GPS), and how to use e-mail via radio. Addresses the critical use of ham radio for replacing downe

  6. Radiography of Spanish Radio

    Directory of Open Access Journals (Sweden)

    Dra. Emma Rodero Antón

    2007-01-01

    Full Text Available In its eighty years of existence, radio has been always characterized to adapt to the social, cultural and technological transformations. Thus it has been until this moment. Nevertheless, some years ago, the authors and professionals of this medium have been detecting a stagnation that affects to its structure. At a time in continuous technological evolution, radio demands a deep transformation. For that reason, from the conviction of which the future radio, public and commercial, will necessarily have to renew itself, in this paper we establish ten problems and their possible solutions to the radio crisis in order to draw an x-ray of radio in Spain. Radio has future, but it is necessary to work actively by it. That the radio continues being part of sound of our life, it will depend on the work of all: companies, advertisers, professionals, students, investigators and listeners.

  7. A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells.

    Directory of Open Access Journals (Sweden)

    Je-Hyuk Lee

    2009-11-01

    Full Text Available Normal variation in gene expression due to regulatory polymorphisms is often masked by biological and experimental noise. In addition, some regulatory polymorphisms may become apparent only in specific tissues. We derived human induced pluripotent stem (iPS cells from adult skin primary fibroblasts and attempted to detect tissue-specific cis-regulatory variants using in vitro cell differentiation. We used padlock probes and high-throughput sequencing for digital RNA allelotyping and measured allele-specific gene expression in primary fibroblasts, lymphoblastoid cells, iPS cells, and their differentiated derivatives. We show that allele-specific expression is both cell type and genotype-dependent, but the majority of detectable allele-specific expression loci remains consistent despite large changes in the cell type or the experimental condition following iPS reprogramming, except on the X-chromosome. We show that our approach to mapping cis-regulatory variants reduces in vitro experimental noise and reveals additional tissue-specific variants using skin-derived human iPS cells.

  8. Neutron noise in nuclear reactors

    International Nuclear Information System (INIS)

    Blaquiere, A.; Pachowska, R.

    1961-06-01

    The power of a nuclear reactor, in the operating conditions, presents fluctuations due to various causes. This random behaviour can be included in the study of 'noises'. Among other sources of noise, we analyse hereafter the fluctuations due: a) to the discontinuous emissions of neutrons from an independent source; b) to the multiplication of neutrons inside the reactor. The method which we present makes use of the analogies between the rules governing a nuclear reactor in operation and a number of radio-electrical systems, in particular the feed-back loops. The reactor can be characterized by its 'passing band' and is described as a system submitted to a sequence of random pulses. In non linear operating condition, the effect of neutron noise is defined by means of a non-linear functional, this theory is thus related to previous works the references of which are given at the end of the present report. This leads us in particular in the case of nuclear reactors to some results given by A. Blaquiere in the case of radio-electrical loops. (author) [fr

  9. Direction of Radio Finding via MUSIC (Multiple Signal Classification) Algorithm for Hardware Design System

    Science.gov (United States)

    Zhang, Zheng

    2017-10-01

    Concept of radio direction finding systems, which use radio direction finding is based on digital signal processing algorithms. Thus, the radio direction finding system becomes capable to locate and track signals by the both. Performance of radio direction finding significantly depends on effectiveness of digital signal processing algorithms. The algorithm uses the Direction of Arrival (DOA) algorithms to estimate the number of incidents plane waves on the antenna array and their angle of incidence. This manuscript investigates implementation of the DOA algorithms (MUSIC) on the uniform linear array in the presence of white noise. The experiment results exhibit that MUSIC algorithm changed well with the radio direction.

  10. Senior radio listeners

    DEFF Research Database (Denmark)

    Blaakilde, Anne Leonora

    Radiobroadcasting and the hardware materialization of radio have during the 20th century changed significantly, which means that senior radio listeners have travelled along with this evolution from large, impressive radio furnitures to DAB and small, wireless, mobile devices, and from grave...... and solemn radio voices to lightharted, laughing and chatting speakers. Senior radio listerners have experienced the development and refinements of technique, content and genres. It is now expected of all media users that they are capable of crossing media, combining, juggling and jumping between various...... media platforms, not the least when listening to radio. The elder generation is no exception from this. Recently, for instance, the Danish public broadcast DR has carried out an exodus of programmes targeted for the senior segment. These programmes are removed from regular FM and sent to DAB receivers...

  11. Can a Human-Induced Climate Disaster be Avoided?

    Science.gov (United States)

    Watson, R.

    2012-12-01

    Emissions of greenhouse gases (GHG) are one of the greatest threats to our future prosperity. World emissions are currently around 50 billion tonnes of carbon dioxide-equivalent per annum and are growing rapidly. Atmospheric concentrations of GHG emissions in the atmosphere have increased, to over 400ppm of CO2e today, even after taking the offsetting radiative effects of aerosols into account, and are increasing at a rate of around 2.5ppm per year. The world's current lack of "adequate" commitments to reduce emissions are consistent with at least a 3oC rise (50-50 chance) in temperature: a temperature not seen on the planet for around 3 million years, with serious risks of 5oC rise: a temperature not seen on the planet for around 30 million years. So what are the implications of a 3-5oC rise in temperature, with associated changes in, rising sea levels, retreating mountain glaciers, melting of the Greenland ice cap, shrinking Arctic Sea ice, especially in summer, increasing frequency of extreme weather events, such as heat waves, floods, and droughts, and intensification of cyclonic events, such as hurricanes in the Atlantic. Even a 2oC increase in mean surface temperatures will adversely affect freshwater, food and fiber, natural ecosystems, coastal systems and low-lying areas, human health and social systems, especially in developing countries. The impacts of 3-5oC will be extensive, predominantly negative, undermine development and poverty alleviation goals and cut across most sectors. To address human-induced climate change requires a transition to a low carbon economy, which will require rapid technological evolution in the efficiency of energy use, environmentally sound low-carbon renewable energy sources and carbon capture and storage. The longer we wait to transition to a low carbon economy the more we are locked into a high carbon energy system with consequent environmental damage to ecological and socio-economic systems. Unfortunately the political will

  12. Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Mononuclear Cells Using Sendai Virus.

    Science.gov (United States)

    Soares, Filipa A C; Pedersen, Roger A; Vallier, Ludovic

    2016-01-01

    This protocol describes the efficient isolation of peripheral blood mononuclear cells from circulating blood via density gradient centrifugation and subsequent generation of integration-free human induced pluripotent stem cells. Peripheral blood mononuclear cells are cultured for 9 days to allow expansion of the erythroblast population. The erythroblasts are then used to derive human induced pluripotent stem cells using Sendai viral vectors, each expressing one of the four reprogramming factors Oct4, Sox2, Klf4, and c-Myc.

  13. Noise in Optical Amplifiers

    DEFF Research Database (Denmark)

    Jeppesen, Palle

    1997-01-01

    Noise in optical amplifiers is discussed on the basis of photons and electromagntic fields. Formulas for quantum noise from spontaneous emission, signal-spontaneous beat noise and spontaneous-spontaneous beat noise are derived.......Noise in optical amplifiers is discussed on the basis of photons and electromagntic fields. Formulas for quantum noise from spontaneous emission, signal-spontaneous beat noise and spontaneous-spontaneous beat noise are derived....

  14. Noise pollution resources compendium

    Science.gov (United States)

    1973-01-01

    Abstracts of reports concerning noise pollution are presented. The abstracts are grouped in the following areas of activity: (1) sources of noise, (2) noise detection and measurement, (3) noise abatement and control, (4) physical effects of noise and (5) social effects of noise.

  15. Yesterday's noise - today's signal

    International Nuclear Information System (INIS)

    Serdula, K.J.

    1978-01-01

    Plant performance can be improved by noise analysis. This paper describes noise characteristics, imposed noise and response functions, a case history of cost benefits derived from application of noise analysis techniques, areas for application of noise analysis techniques with special reference to the Gentilly-1 nuclear generating station, and the validity of noise measurement results. (E.C.B.)

  16. Ionosphere and Radio Communication

    Indian Academy of Sciences (India)

    The upperionosphere is used for radio communication and navigationas it reflects long, medium, as well as short radio waves. Sincesolar radiation is the main cause of the existence of ionosphere,any variation in the radiations can affect the entireradio communication system. This article attempts to brieflyintroduce the ...

  17. Writing for Radio.

    Science.gov (United States)

    Tupper, Marianna S.

    1995-01-01

    Describes a 24-hour commercial radio station simulation class project for eighth-grade language arts. Students wrote their own scripts, chose music and were disc jockeys on their own music and talk shows, and prepared news and traffic reports. Guest speakers from actual commercial radio came in to discuss issues such as advertising, censorship,…

  18. Valuing commercial radio licences

    NARCIS (Netherlands)

    Kerste, M.; Poort, J.; van Eijk, N.

    2015-01-01

    Within the EU regulatory framework, licensees for commercial radio broadcasting may be charged a fee to ensure optimal allocation of scarce resources but not to maximize public revenues. While radio licence renewal occurs in many EU countries, an objective, model-based approach for setting licence

  19. The Radio Jove Project

    Science.gov (United States)

    Thieman, J. R.

    2010-01-01

    The Radio love Project is a hands-on education and outreach project in which students, or any other interested individuals or groups build a radio telescope from a kit, operate the radio telescope, transmit the resulting signals through the internet if desired, analyze the results, and share the results with others through archives or general discussions among the observers. Radio love is intended to provide an introduction to radio astronomy for the observer. The equipment allows the user to observe radio signals from Jupiter, the Sun, the galaxy, and Earth-based radiation both natural and man-made. The project was started through a NASA Director's Discretionary Fund grant more than ten years ago. it has continued to be carried out through the dedicated efforts of a group of mainly volunteers. Dearly 1500 kits have been distributed throughout the world. Participation can also be done without building a kit. Pre-built kits are available. Users can also monitor remote radio telescopes through the internet using free downloadable software available through the radiosky.com website. There have been many stories of prize-winning projects, inspirational results, collaborative efforts, etc. We continue to build the community of observers and are always open to new thoughts about how to inspire the observers to still greater involvement in the science and technology associated with Radio Jove.

  20. Boom Booom Net Radio

    DEFF Research Database (Denmark)

    Grimshaw, Mark Nicholas; Yong, Louisa; Dobie, Ian

    1999-01-01

    of an existing Internet radio station; Boom Booom Net Radio. Whilst necessity dictates some use of technology-related terminology, wherever possible we have endeavoured to keep such jargon to a minimum and to either explain it in the text or to provide further explanation in the appended glossary....

  1. Quantum Noise

    International Nuclear Information System (INIS)

    Beenakker, C W J

    2005-01-01

    Quantum Noise is advertised as a handbook, and this is indeed how it functions for me these days: it is a book that I keep within hand's reach, ready to be consulted on the proper use of quantum stochastic methods in the course of my research on quantum dots. I should point out that quantum optics, the target field for this book, is not my field by training. So I have much to learn, and find this handbook to be a reliable and helpful guide. Crispin Gardiner previously wrote the Handbook of Stochastic Methods (also published by Springer), which provides an overview of methods in classical statistical physics. Quantum Noise, written jointly with Peter Zoller, is the counterpart for quantum statistical physics, and indeed the two books rely on each other by frequent cross referencing. The fundamental problem addressed by Quantum Noise is how the quantum dynamics of an open system can be described statistically by treating the environment as a source of noise. This is a general problem in condensed matter physics (in particular in the context of Josephson junctions) and in quantum optics. The emphasis in this book in on the optical applications (for condensed matter applications one could consult Quantum Dissipative Systems by Ulrich Weiss, published by World Scientific). The optical applications centre around the interaction of light with atoms, where the atoms represent the open system and the light is the noisy environment. A complete description of the production and detection of non-classical states of radiation (such as squeezed states) can be obtained using one of the equivalent quantum stochastic formulations: the quantum Langevin equation for the field operators (in either the Ito or the Stratonovich form), the Master equation for the density matrix, or the stochastic Schroedinger equation for the wave functions. Each formulation is fully developed here (as one would expect from a handbook), with detailed instructions on how to go from one to the other. The

  2. Radio drama adaptations: an approach towards an analytical methodology

    NARCIS (Netherlands)

    Huwiler, E.

    2010-01-01

    This article establishes a methodology with which radio drama pieces can be analysed. It thereby integrates all features the art form has to offer: voices, music, noises, but also technical features like cutting and mixing contribute to the narrative that is being told. This approach emphasizes the

  3. Noise thermometer

    Energy Technology Data Exchange (ETDEWEB)

    Von Brixy, H. [Forschungszentrum Juelich GmbH (Germany); Kakuta, Tsunemi

    1996-03-01

    The noise thermometry (NT) is a temperature measuring method by which the absolute temperature measurement can be performed with a very high accuracy and without any influence of ambient environments and of the thermal history of its NT sensor (electric resistor). Hence it is quite suitable for application as a standard thermometry to the in-situ temperature calibration of incore thermocouples. The KFA Juelich had played a pioneering role in the development of NT and applied the results successfully to the AVR for testing its feasibility. In this report, all about the NT including its principle, sensor elements and system configurations are presented together with the experiences in the AVR and the results of investigation to apply it to high temperature measurement. The NT can be adopted as a standard method for incore temperature measurement and in situ temperature calibration in the HTTR. (author). 85 refs.

  4. Noise thermometer

    International Nuclear Information System (INIS)

    Von Brixy, H.; Kakuta, Tsunemi.

    1996-03-01

    The noise thermometry (NT) is a temperature measuring method by which the absolute temperature measurement can be performed with a very high accuracy and without any influence of ambient environments and of the thermal history of its NT sensor (electric resistor). Hence it is quite suitable for application as a standard thermometry to the in-situ temperature calibration of incore thermocouples. The KFA Juelich had played a pioneering role in the development of NT and applied the results successfully to the AVR for testing its feasibility. In this report, all about the NT including its principle, sensor elements and system configurations are presented together with the experiences in the AVR and the results of investigation to apply it to high temperature measurement. The NT can be adopted as a standard method for incore temperature measurement and in situ temperature calibration in the HTTR. (author). 85 refs

  5. Unlocking radio broadcasts

    DEFF Research Database (Denmark)

    Skov, Mette; Lykke, Marianne

    2012-01-01

    This poster reports the preliminary results of a user study uncovering the information seeking behaviour of humanities scholars dedicated to radio research. The study is part of an interdisciplinary research project on radio culture and auditory resources. The purpose of the study is to inform...... the design of information architecture and interaction design of a research infrastructure that will enable future radio and audio based research. Results from a questionnaire survey on humanities scholars‟ research interest and information needs, preferred access points, and indexing levels are reported....... Finally, a flexible metadata schema is suggested, that includes both general metadata and highly media and research project specific metadata....

  6. Radio y elecciones

    Directory of Open Access Journals (Sweden)

    Alma Rosa Alva de la Selva

    2000-01-01

    Full Text Available En este trabajo se analiza el comportamiento de la radio en México ante la contienda electoral de julio de 2000. Se examina el papel de la radio como espacio para la discusión política, así como el tratamiento informativo que hizo del tema. Asimismo, se analiza la posible repercusión de factores de reciente surgimiento en el panorama radiofónico para un manejo más autónomo de la información política en la radio

  7. Social cognitive radio networks

    CERN Document Server

    Chen, Xu

    2015-01-01

    This brief presents research results on social cognitive radio networks, a transformational and innovative networking paradigm that promotes the nexus between social interactions and cognitive radio networks. Along with a review of the research literature, the text examines the key motivation and challenges of social cognitive radio network design. Three socially inspired distributed spectrum sharing mechanisms are introduced: adaptive channel recommendation mechanism, imitation-based social spectrum sharing mechanism, and evolutionarily stable spectrum access mechanism. The brief concludes with a discussion of future research directions which ascertains that exploiting social interactions for distributed spectrum sharing will advance the state-of-the-art of cognitive radio network design, spur a new line of thinking for future wireless networks, and enable novel wireless service and applications.

  8. NOAA Weather Radio

    Science.gov (United States)

    del tiempo incluido. Si eres quieres ser avisado de las advertencias y relojes de día o de noche, un Weather Radio relojes son independientes o basadas en el Condado (parroquia basados en Luisiana), aunque

  9. The digital sport radio.

    Directory of Open Access Journals (Sweden)

    Hilario José ROMERO BEJARANO

    2014-07-01

    Full Text Available Radio has been immersed in recent years in a phase of technological integration and business of multimedia, as well as diversification of systems and channels for broadcasting. In addition, Internet has been consolidated as the platform of digital radio that more has evolved as a result of its continued expansion. However, the merger radio-Internet must be understood as a new form of communication, and not solely as a new complementary medium. In this context, it is of great interest to analyze that transformations in the way of reception, contents, languages, programs and schedules, has brought with it for the radio that integration. To this end is taken as main reference the sports areas, a key aspect and broadly representative of the current broadcasting landscape.

  10. Music, radio and mediatization

    DEFF Research Database (Denmark)

    Michelsen, Morten; Krogh, Mads

    2016-01-01

    of mediatization where media as such seem to be ascribed agency. Instead, we consider historical accounts of music–radio in order to address the complex nonlinearity of concrete processes of mediatization as they take place in the multiple meetings between a decentred notion of radio and musical life.......Mediatization has become a key concept for understanding the relations between media and other cultural and social fields. Contributing to the discussions related to the concept of mediatization, this article discusses how practices of radio and music(al life) influence each other. We follow Deacon......’s and Stanyer’s advice to supplement the concept of mediatization with ‘a series of additional concepts at lower levels of abstraction’ and suggest, in this respect, the notion of heterogeneous milieus of music–radio. Hereby, we turn away from the all-encompassing perspectives related to the concept...

  11. ITSY Handheld Software Radio

    National Research Council Canada - National Science Library

    Bose, Vanu

    2001-01-01

    .... A handheld software radio platform would enable the construction of devices that could inter-operate with multiple legacy systems, download new waveforms and be used to construct adhoc networks...

  12. Structure in radio galaxies

    International Nuclear Information System (INIS)

    Breugel, W. van.

    1980-01-01

    It is shown that radio jets are a rather common phenomenon in radio galaxies. Jets can be disguised as trails in head-tail sources, bridges in double sources or simply remain undetected because of lack of resolution and sensitivity. It is natural to associate these jets with the channels which had previously been suggested to supply energy to the extended radio lobes. The observations of optical emission suggest that a continuous non-thermal spectrum extending from 10 9 to 10 15 Hz is a common property of jets. Because significant amounts of interstellar matter are also observed in each of the galaxies surveyed it seems that models for jets which involve an interaction with this medium may be most appropriate. New information about the overall structure of extended radio sources has been obtained from the detailed multifrequency study with the WSRT. (Auth.)

  13. Radio and television interference caused by corona discharges from high-voltage transmission lines

    International Nuclear Information System (INIS)

    Sarmadi, M.

    1996-01-01

    Increase in power utility loads in industrialized countries, as well as developing countries, demands a higher level of transmission line voltage. Radio interference (RI) problems have been determined to be a limiting factor in selecting the size of transmission line conductors. Transmission line noise is primarily caused by corona discharges in the immediate vicinity of the conductor. It has been observed that discharges occur during both half-cycles of the applied voltage, but positive corona is usually predominant at AM radio frequencies range with practical high-voltage and extra high-voltage transmission lines. The corona radio noise effect is highly dependent upon the presence of particles on the surface of the conductor and the increase of the electrical gradient beyond the breakdown value of the air. Therefore, corona radio noise varies significantly with the weather and atmospheric conditions and generally increases by 10 to 30 dB in foul weather

  14. Direct observations of low-energy solar electrons associated with a type 3 solar radio burst

    Science.gov (United States)

    Frank, L. A.; Gurnett, D. A.

    1972-01-01

    On 6 April 1971 a solar X-ray flare and a type 3 solar radio noise burst were observed with instrumentation on the eccentric-orbiting satellite IMP 6. The type 3 solar radio noise burst was detected down to a frequency of 31 kHz. A highly anisotropic packet of low-energy solar electron intensities arrived at the satellite approximately 6000 seconds after the onset of the solar flare. This packet of solar electron intensities was observed for 4200 seconds. Maximum differential intensities of the solar electrons were in the energy range of one to several keV. The frequency drift rate of the type 3 radio noise at frequencies below 178 kHz also indicated an average particle speed corresponding to that of a 3-keV electron. The simultaneous observations of these solar electron intensities and of the type 3 solar radio burst are presented, and their interrelationships are explored.

  15. Wireless radio a history

    CERN Document Server

    Coe, Lewis

    2006-01-01

    ""Informative...recommended""--Choice; ""interesting...a good read...well worth reading""--Contact Magazine. This history first looks at Marconi's wireless communications system and then explores its many applications, including marine radio, cellular telephones, police and military uses, television and radar. Radio collecting is also discussed, and brief biographies are provided for the major figures in the development and use of the wireless.

  16. ¿Radios ciudadanas?

    OpenAIRE

    López Vigil, José Ignacio

    1998-01-01

    Educativas, sindicales, populares, comunitarias, libres, rebeldes, participativas, alternativas, alterativas, han sido las denominaciones de la radio cuando su proyecto está al servicio de la gente. Palabras apropiadas y nobles -dice elautor-pero devaluadas, a las que ahora se agrega la radio ciudadana, para relievarla como ejercicio depoder y espacio de verdadera participación de la genteenla vida de su nación.

  17. Classics in radio astronomy

    CERN Document Server

    Sullivan, Woodruff Turner

    1982-01-01

    Radio techniques were the nrst to lead astronomy away from the quiescent and limited Universe revealed by traditional observations at optical wave­ lengths. In the earliest days of radio astronomy, a handful of radio physicists and engineers made one startling discovery after another as they opened up the radio sky. With this collection of classic papers and the extensive intro­ ductory material, the reader can experience these exciting discoveries, as well as understand the developing techniques and follow the motivations which prompted the various lines of inquiry. For instance he or she will follow in detail the several attempts to detect radio waves from the sun at the turn of the century; the unravelling by Jansky of a "steady hiss type static"; the incredible story of Reber who built a 9 meter dish in his backyard in 1937 and then mapped the Milky Way; the vital discoveries by Hey and colleagues of radio bursts from the Sun and of a discrete source in the constellation of Cygnus; the development of re...

  18. Inhibitory noise

    Directory of Open Access Journals (Sweden)

    Alain Destexhe

    2010-03-01

    Full Text Available Cortical neurons in vivo may operate in high-conductance states, in which the major part of the neuron's input conductance is due to synaptic activity, sometimes several-fold larger than the resting conductance. We examine here the contribution of inhibition in such high-conductance states. At the level of the absolute conductance values, several studies have shown that cortical neurons in vivo are characterized by strong inhibitory conductances. However, conductances are balanced and spiking activity is mostly determined by fluctuations, but not much is known about excitatory and inhibitory contributions to these fluctuations. Models and dynamic-clamp experiments show that, during high-conductance states, spikes are mainly determined by fluctuations of inhibition, or by inhibitory noise. This stands in contrast to low-conductance states, in which excitatory conductances determine spiking activity. To determine these contributions from experimental data, maximum likelihood methods can be designed and applied to intracellular recordings in vivo. Such methods indicate that action potentials are indeed mostly correlated with inhibitory fluctuations in awake animals. These results argue for a determinant role for inhibitory fluctuations in evoking spikes, and do not support feed-forward modes of processing, for which opposite patterns are predicted.

  19. The first radio astronomy from space - RAE

    Science.gov (United States)

    Kaiser, M. L.

    1987-01-01

    The spacecraft design, instrumentation, and performance of the Radio Astronomy Explorer (RAE) satellites (RAE-1 launched to earth orbit in 1968 and RAE-2 launched to lunar orbit in 1972) are reviewed and illustrated with drawings, diagrams, and graphs of typical data. Consideration is given to the three pairs of antennas, the Ryle-Vonberg and burst radiometers, and problems encountered with antenna deployment and observing patterns. Results summarized include observations of type III solar bursts, the spectral distribution of cosmic noise in broad sky regions, Jupiter at low frequencies, and auroral kilometric radiation (AKR) from the earth. The importance of avoiding the AKR bands in designing future space observatories is stressed.

  20. Noise and Hearing Protection

    Science.gov (United States)

    ... ENTCareers Marketplace Find an ENT Doctor Near You Noise and Hearing Protection Noise and Hearing Protection Patient ... it is. How can I tell if a noise is dangerous? People differ in their sensitivity to ...

  1. Solar radio observations and interpretations

    International Nuclear Information System (INIS)

    Rosenberg, H.

    1976-01-01

    The recent solar radio observations related to flares are reviewed for the frequency range of a few kilohertz to several gigahertz. The analysis of the radio data leads to boundary conditions on the acceleration processes which are responsible for the fast particles which cause radio emission. The role and cause of plasma turbulence at the plasma-frequency and at much lower frequencies is discussed in relation to the acceleration processes and the radio emission mechanisms for the various radio bursts. (author)

  2. CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes

    NARCIS (Netherlands)

    Hasegawa, Yuki; Tang, Dave; Takahashi, Naoko; Hayashizaki, Yoshihide; Forrest, Alistair R R; Suzuki, Harukazu; Clevers, Hans

    2014-01-01

    Standard culture of human induced pluripotent stem cells (hiPSCs) requires basic Fibroblast Growth Factor (bFGF) to maintain the pluripotent state, whereas hiPSC more closely resemble epiblast stem cells than true naïve state ES which requires LIF to maintain pluripotency. Here we show that

  3. Choices for Induction of Pluripotency: Recent Developments in Human Induced Pluripotent Stem Cell Reprogramming Strategies

    NARCIS (Netherlands)

    Brouwer, M.; Zhou, Huiqing; Nadif Kasri, N.

    2016-01-01

    The ability to generate human induced pluripotent stem cells (iPSCs) from somatic cells provides tremendous promises for regenerative medicine and its use has widely increased over recent years. However, reprogramming efficiencies remain low and chromosomal instability and tumorigenic potential are

  4. A method of background noise cancellation for SQUID applications

    International Nuclear Information System (INIS)

    He, D F; Yoshizawa, M

    2003-01-01

    When superconducting quantum inference devices (SQUIDs) operate in low-cost shielding or unshielded environments, the environmental background noise should be reduced to increase the signal-to-noise ratio. In this paper we present a background noise cancellation method based on a spectral subtraction algorithm. We first measure the background noise and estimate the noise spectrum using fast Fourier transform (FFT), then we subtract the spectrum of background noise from that of the observed noisy signal and the signal can be reconstructed by inverse FFT of the subtracted spectrum. With this method, the background noise, especially stationary inferences, can be suppressed well and the signal-to-noise ratio can be increased. Using high-T C radio-frequency SQUID gradiometer and magnetometer, we have measured the magnetic field produced by a watch, which was placed 35 cm under a SQUID. After noise cancellation, the signal-to-noise ratio could be greatly increased. We also used this method to eliminate the vibration noise of a cryocooler SQUID

  5. Galactic radio astronomy

    CERN Document Server

    Sofue, Yoshiaki

    2017-01-01

    This book is a concise primer on galactic radio astronomy for undergraduate and graduate students, and provides wide coverage of galactic astronomy and astrophysics such as the physics of interstellar matter and the dynamics and structure of the Milky Way Galaxy and galaxies. Radio astronomy and its technological development have led to significant progress in galactic astronomy and contributed to understanding interstellar matter and galactic structures. The book begins with the fundamental physics of radio-wave radiation, i.e., black body radiation, thermal emission, synchrotron radiation, and HI and molecular line emissions. The author then gives overviews of ingredients of galactic physics, including interstellar matter such as the neutral (HI), molecular hydrogen, and ionized gases, as well as magnetic fields in galaxies. In addition, more advanced topics relevant to the Galaxy and galaxies are also contained here: star formation, supernova remnants, the Galactic Center and black holes, galactic dynamics...

  6. Radio structure in quasars

    International Nuclear Information System (INIS)

    Barthel, P.D.

    1984-01-01

    In this thesis, observational attention is given to the extended extragalactic radio sources associated with quasars. The isolated compact radio sources, often identified with quasars, are only included in the discussions. Three aspects of the radio structure in quasars and their cosmic evolution are considered: a study of the parsec scale morphology in quasar cores, in relation to the extended morphologies; an investigation of possible epoch dependent hotspot properties as well as a more detailed investigation of this fine scale structure; a VLA project was carried out to obtain morphological information on scales of 0.5 arcsec on high redshift quasars and to investigate possible epoch dependent morphological properties. MERLIN observations at 0.1 arcsec resolution to supplement the VLA data were initiated. (Auth.)

  7. The effect of solar radio bursts on the GNSS radio occultation signals

    Science.gov (United States)

    Yue, Xinan; Schreiner, William S.; Kuo, Ying-Hwa; Zhao, Biqiang; Wan, Weixing; Ren, Zhipeng; Liu, Libo; Wei, Yong; Lei, Jiuhou; Solomon, Stan; Rocken, Christian

    2013-09-01

    radio burst (SRB) is the radio wave emission after a solar flare, covering a broad frequency range, originated from the Sun's atmosphere. During the SRB occurrence, some specific frequency radio wave could interfere with the Global Navigation Satellite System (GNSS) signals and therefore disturb the received signals. In this study, the low Earth orbit- (LEO-) based high-resolution GNSS radio occultation (RO) signals from multiple satellites (COSMIC, CHAMP, GRACE, SAC-C, Metop-A, and TerraSAR-X) processed in University Corporation for Atmospheric Research (UCAR) were first used to evaluate the effect of SRB on the RO technique. The radio solar telescope network (RSTN) observed radio flux was used to represent SRB occurrence. An extreme case during 6 December 2006 and statistical analysis during April 2006 to September 2012 were studied. The LEO RO signals show frequent loss of lock (LOL), simultaneous decrease on L1 and L2 signal-to-noise ratio (SNR) globally during daytime, small-scale perturbations of SNR, and decreased successful retrieval percentage (SRP) for both ionospheric and atmospheric occultations during SRB occurrence. A potential harmonic band interference was identified. Either decreased data volume or data quality will influence weather prediction, climate study, and space weather monitoring by using RO data during SRB time. Statistically, the SRP of ionospheric and atmospheric occultation retrieval shows ~4% and ~13% decrease, respectively, while the SNR of L1 and L2 show ~5.7% and ~11.7% decrease, respectively. A threshold value of ~1807 SFU of 1415 MHz frequency, which can result in observable GNSS SNR decrease, was derived based on our statistical analysis.

  8. Active Noise Control for Dishwasher noise

    Science.gov (United States)

    Lee, Nokhaeng; Park, Youngjin

    2016-09-01

    The dishwasher is a useful home appliance and continually used for automatically washing dishes. It's commonly placed in the kitchen with built-in style for practicality and better use of space. In this environment, people are easily exposed to dishwasher noise, so it is an important issue for the consumers, especially for the people living in open and narrow space. Recently, the sound power levels of the noise are about 40 - 50 dBA. It could be achieved by removal of noise sources and passive means of insulating acoustical path. For more reduction, such a quiet mode with the lower speed of cycle has been introduced, but this deteriorates the washing capacity. Under this background, we propose active noise control for dishwasher noise. It is observed that the noise is propagating mainly from the lower part of the front side. Control speakers are placed in the part for the collocation. Observation part of estimating sound field distribution and control part of generating the anti-noise are designed for active noise control. Simulation result shows proposed active noise control scheme could have a potential application for dishwasher noise reduction.

  9. Radio Emission from Supernovae

    International Nuclear Information System (INIS)

    Weiler, Kurt W.; Panagia, Nino; Sramek, Richard A.; Van Dyk, Schuyler D.; Williams, Christopher L.; Stockdale, Christopher J.; Kelley, Matthew T.

    2009-01-01

    Study of radio supernovae over the past 27 years includes more than three dozen detected objects and more than 150 upper limits. From this work it is possible to identify classes of radio properties, demonstrate conformance to and deviations from existing models, estimate the density and structure of the circumstellar material and, by inference, the evolution of the presupernova stellar wind, and reveal the last stages of stellar evolution before explosion. It is also possible to detect ionized hydrogen along the line of sight, to demonstrate binary properties of the presupernova stellar system, and to detect dumpiness of the circumstellar material.

  10. Radio emission from Jupiter

    International Nuclear Information System (INIS)

    Velusamy, T.

    1976-01-01

    The basic features of the different radio emissions from the planet Jupiter are reviewed. These radio emissions characterized into three types as thermal, decimetric and decametric, are discussed. The coherent emission mechanism for the origin of the decametric bursts and the acceleration mechanism for relativistic electrons in the decimetric radiation have not been properly understood. The emissions are much related to the magnetic field of Jupiter. The system III rotation period for Jupiter has been calculated as 092 55 m 29.74 S. (A.K.)

  11. ¿Radios Comunitarias?

    OpenAIRE

    José Ignacio López Vigil

    2015-01-01

    Varias han sido las denominaciones dadas a la radio cuando su proyecto está al servicio de la gente. Palabras apropiadas pero devaluadas al decir del autor, a las que ahora se suma otras radios ciudadanas. Ciudadana para relievarla como ejercicio de poder y espacio de verdadera participación de la gente en la vida de su nación. Ciudadanos son los que piensan con cabeza propia y pesan en la opinión pública. Presenta una sinopsis de la historia de éstas desde 1974. Señala que la competencia obl...

  12. Non-Markovian noise

    International Nuclear Information System (INIS)

    Fulinski, A.

    1994-01-01

    The properties of non-Markovian noises with exponentially correlated memory are discussed. Considered are dichotomic noise, white shot noise, Gaussian white noise, and Gaussian colored noise. The stationary correlation functions of the non-Markovian versions of these noises are given by linear combinations of two or three exponential functions (colored noises) or of the δ function and exponential function (white noises). The non-Markovian white noises are well defined only when the kernel of the non-Markovian master equation contains a nonzero admixture of a Markovian term. Approximate equations governing the probability densities for processes driven by such non-Markovian noises are derived, including non-Markovian versions of the Fokker-Planck equation and the telegrapher's equation. As an example, it is shown how the non-Markovian nature changes the behavior of the driven linear process

  13. Phase Evolution of the Crab Pulsar between Radio and X-Ray

    Energy Technology Data Exchange (ETDEWEB)

    Yan, L. L.; Ge, M. Y.; Zheng, S. J.; Lu, F. J.; Tuo, Y. L.; Zhang, S. N.; Lu, Y. [Key Laboratory of Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Yuan, J. P.; Tong, H. [Xinjiang Astronomical Observatory, Chinese Academy of Sciences, Urumqi, Xinjiang 830011 (China); Han, J. L. [National Astronomical Observatory, Chinese Academy of Sciences, Jia 20 Datun Road, Beijing 100012 (China); Du, Y. J., E-mail: yanlinli@ihep.ac.cn [Qian Xuesen Laboratory of Space Technology, No. 104, Youyi Road, Haidian District, Beijing 100094 (China)

    2017-08-20

    We study the X-ray phases of the Crab pulsar utilizing the 11-year observations from the Rossi X-ray Timing Explorer , 6-year radio observations from Nanshan Telescope, and the ephemeris from Jodrell Bank Observatory. It is found that the X-ray phases in different energy bands and the radio phases from the Nanshan Telescope show similar behaviors, including long-time evolution and short-time variations. Such strong correlations between the X-ray and radio phases imply that the radio and X-ray timing noises are both generated from the pulsar spin that cannot be well described by the the monthly ephemeris from the Jodrell Bank observatory. When using the Nanshan phases as references to study the X-ray timing noise, it has a significantly smaller variation amplitude and shows no long-time evolution, with a change rate of (−1.1 ± 1.1) × 10{sup −7} periods per day. These results show that the distance of the X-ray and radio emission regions on the Crab pulsar has no detectable secular change, and it is unlikely that the timing noises resulted from any unique physical processes in the radio or X-ray emitting regions. The similar behaviors of the X-ray and radio timing noises also imply that the variation of the interstellar medium is not the origin of the Crab pulsar’s timing noises, which is consistent with the results obtained from the multi-frequency radio observations of PSR B1540−06.

  14. Measurement and control of occupational noise

    International Nuclear Information System (INIS)

    Elammari, Muftah Faraj

    2007-01-01

    High level of environmental and occupational noise remain a problem all over the world. As problems and complaints increased dramatically by the end of the 19th and beginning of the 20th centuries focusing on the problem was intensified. In this thesis occupational noise levels at different places were measured and compared with the international permissible levels using the integrating sound level meter (Quest 2800). The calibration of the instrument was carried out before and after each measurement using the acoustic calibrator (Quest CA-12B calibrator). The method which was followed was measuring the sound pressure level of the different noise sources over a broad frequency band covering the audible frequency range using the (octave band filter, model OB-100), disregrading variation with time. Since the human ear is most sensitive in the 2-5 khz range of frequencies and least sensitive at extremely high and low frequencies the instrument was adjusted on the A weighting net work which varies with frequencies in a very similar way as that of the human ear. From the obtained results, some noise levels which were recorded were within the permissible levels i.e. below 90 dba and some noise levels were higher than the permissible limit as in janzour textile factory (95 dba), The welding workshop (120 dba), Benghazi Macaroni factory (100 dba), and near the air blowers at Zletin cement factory, Benghazi cement factory (97-10-dba) in these cases suggestions were made to minimize the problem. Concerning the noise control, four methods of noise control were tested, these methods were: reducing noise by sound absorbing material at Sirt local broadcasting radio, reducing noise by keeping a distance from the noise source, at the Boilers hall at REWDC, reducing noise by enclosures, at the compressors room at Zletin cement factory, and finally reducing noise by performing regular maintenance at Garabolli photo development centre. The percentage of noise reduction was 21%, 12

  15. Spectrum management and radio resource management considering cognitive radio systems

    NARCIS (Netherlands)

    Haartsen, J.C.; Wieweg, Lasse; Huschke, Jörg

    2005-01-01

    International fora and some national administrations define a cognitive radio (CR) as a pioneering radio communication system that would be capable of altering and adapting its transmitter and receiver parameters based on communication and the exchange of information with related detectable radio

  16. Wideband CMOS low noise amplifier including an active balun

    NARCIS (Netherlands)

    Blaakmeer, S.C.; Klumperink, Eric A.M.; Leenaerts, D.M.W.; Nauta, Bram

    2007-01-01

    An inductorless LNA with active balun is proposed for multi-standard radio applications between 100MHz and 6GHz [1]. It exploits a combination of a common-gate (CG) stage and an common-source (CS) stage with replica biasing to maximize balanced operation, while simultaneously canceling the noise and

  17. Measurement of the Low Frequency Noise of MOSFETs under Large Signal RF Excitation

    NARCIS (Netherlands)

    van der Wel, A.P.; Klumperink, Eric A.M.; Nauta, Bram

    2002-01-01

    A measurement technique [1] is presented that allows measurement of MOSFET low frequency (LF) noise under large signal RF (Radio Frequency) excitation. Measurements indicate that MOSFETS exhibit a reduction in LF noise when they are cycled from inversion to accummulation and that this reduction does

  18. Compact radio sources

    International Nuclear Information System (INIS)

    Altschuler, D.R.

    1975-01-01

    Eighty-seven compact radio sources were monitored between 1971 and 1974 with the National Radio Astronomy Observatory interferometer. Both flux density and polarization were measured at intervals of about one month at wavelengths of 3.7 and 11.1 cms. Forty-four sources showed definite variability in their total and/or polarized flux density. The variations in polarization were of a shorter time scale than the corresponding flux density variations. Some of the qualitative features of an expanding source model were observed. The data suggest that some form of injection of relativistic electrons is taking place. The absence of significant depolarization in the variable sources indicates that only a small fraction of the mass of the radio outburst is in the form of non-relativistic plasma. Some of the objects observed belong to the BL-Lacertal class. It is shown that this class is very inhomogeneous in its radio properties. For the violently variable BL-Lacertal type objects the spectrum, flux variations and polarization data strongly suggest that these are very young objects

  19. Valuing commercial radio licences

    NARCIS (Netherlands)

    Kerste, M.; Poort, J.; van Eijk, N.

    2011-01-01

    Within the EU Regulatory Framework, licensees for commercial radio broadcasting may be charged a fee to ensure optimal allocation of scarce resources but not to maximize public revenues. In this paper, it is described how such a fee can be determined for the purpose of licence renewal or extension.

  20. Radio Frequency Identification

    Indian Academy of Sciences (India)

    Radio Frequency Identification (RFID) has been around sinceearly 2000. Its use has currently become commonplace as thecost of RFID tags has rapidly decreased. RFID tags have alsobecome more 'intelligent' with the incorporation of processorsand sensors in them. They are widely used now in manyinnovative ways.

  1. Nanolensed Fast Radio Bursts

    Science.gov (United States)

    Eichler, David

    2017-12-01

    It is suggested that fast radio bursts can probe gravitational lensing by clumpy dark matter objects that range in mass from 10-3 M ⊙-102 M ⊙. They may provide a more sensitive probe than observations of lensings of objects in the Magellanic Clouds, and could find or rule out clumpy dark matter with an extended mass spectrum.

  2. AMATEUR "HAM" RADIO

    Science.gov (United States)

    these cooler months. Did you know your body can cool 25 times faster in water than in air? That water code at 13 or 20 words-per-minute will no longer be required to obtain amateur radio operating be found by contacting the ARRL or using an Internet search engine to search on such topics as "

  3. Radio stars observed in the LAMOST spectral survey

    Science.gov (United States)

    Zhang, Li-Yun; Yue, Qiang; Lu, Hong-Peng; Han, Xian-Ming L.; Zhang, Yong; Shi, Jian-Rong; Wang, Yue-Fei; Hou, Yong-Hui; Zi-Huang, Cao

    2017-09-01

    Radio stars have attracted astronomers’ attention for several decades. To better understand the physics behind stellar radio emissions, it is important to study their optical behaviors. The LAMOST survey provides a large database for researching stellar spectroscopic properties of radio stars. In this work, we concentrate on their spectroscopic properties and infer physical properties from their spectra, such as stellar activity and variability. We mined big data from the LAMOST spectral survey Data Release 2 (DR2), published on 2016 June 30, by cross-matching them with radio stars from FIRST and other surveys. We obtained 783 good stellar spectra with high signal to noise ratio for 659 stars. The criteria for selection were positional coincidence within 1.5‧‧ and LAMOST objects classified as stars. We calculated the equivalent widths (EWs) of the Ca ii H&K, Hδ, Hγ, Hβ, Hα and Ca ii IRT lines by integrating the line profiles. Using the EWs of the Hα line, we detected 147 active stellar spectra of 89 objects having emissions above the Hα continuum. There were also 36 objects with repeated spectra, 28 of which showed chromospheric activity variability. Furthermore, we found 14 radio stars emitting noticeably in the Ca ii IRT lines. The low value of the EW8542/EW8498 ratio for these 14 radio stars possibly alludes to chromospheric plage regions.

  4. Radio emission in the Virgo cluster and in SO galaxies

    International Nuclear Information System (INIS)

    Kotanyi, C.

    1981-01-01

    A survey of the radio continuum emission from the galaxies in the Virgo Cluster is presented. The sample of 274 galaxies in total contains a subsample of 188 galaxies complete down to magntiude msub(p) = 14. The observations consisted mostly of short (10 minutes) observations providing one-dimensional (East-West) strip distributions of the radio brightness at 1.4 GHz, with an East-West resolution of 23'' allowing separation of central sources from extended emission, and an r.m.s. noise level of 2 mJy. The radio emission of SO galaxies is examined. A sample of 145 SO galaxies is obtained by combining the Virgo cluster SO's with the nearby non-cluster SO's. The radio data, mainly from short observations, are used to derive the RLF. The radio emission in SO galaxies is at least three times weaker than that in ellipticals and spirals. Flat-spectrum compact nuclear sources are found in SO galaxies but they are at least 10 times weaker than in elliptical galaxies, which is attributed to the small mass of the bulges in SO's as compared to the mass of elliptical galaxies. The absence of steep-spectrum, extended central sources and of disk radio emission in SO's is attributed to their low neutral hydrogen content. (Auth.)

  5. Performance evaluation of a real time OFDM radio over fiber system at 2.5 GHz using software defined radio SDR

    DEFF Research Database (Denmark)

    David Cepeda, Juan; Rodriguez, Santiago Isaac; Rico-Martinez, Monica

    2017-01-01

    This paper presents the implementation of an OFDM radio over fiber (RoF) system at 2.5 GHz using software defined radio (SDR). In this work, first we present an introduction of the main concepts about radio over fiber and an orthogonal frequency-division multiplexing (OFDM) system at 2.5 GHz......, then we present a comparison of an OFDM RoF system in three scenarios, modifying the wireless distances and the optical fiber distance in order to evaluate the performance of the system taking into account the symbol error rate (SER) vs signal to noise ratio (SNR) curves....

  6. Radio Model-free Noise Reduction of Radio Transmissions with Convolutional Autoencoders

    Science.gov (United States)

    2016-09-01

    as a front end to a long short term memory (LSTM) [12], which may provide another route towards understanding the content or meaning of RF emissions...Exploring Engineering™ (IJITEE) 2:6–9. 12. Sepp Hochreiter and Jurgen Schmidhuber. 1007. “Long Short - term Memory , Neural Computation 9(8):1735–1780. 13...the noisy channel capacity , with no further optimizations. 2 2. METHODS AND EXPERIMENT We will use the terms instance or example to refer to a

  7. Radio images of the planets

    International Nuclear Information System (INIS)

    De Pater, I.

    1990-01-01

    Observations at radio wavelengths make possible detailed studies of planetary atmospheres, magnetospheres, and surface layers. The paper addresses the question of what can be learned from interferometric radio images of planets. Results from single-element radio observations are also discussed. Observations of both the terrestrial and the giant planets are considered. 106 refs

  8. Reduction of environmental MHz noise for SQUID application

    Energy Technology Data Exchange (ETDEWEB)

    Araya, T. [Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531 (Japan)]. E-mail: araya@sup.ee.es.osaka-u.ac.jp; Kitamura, Y. [Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531 (Japan); Kamishiro, M. [Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531 (Japan); Sakuta, K. [Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531 (Japan); Itozaki, H. [Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531 (Japan)]. E-mail: itozaki@ee.es.osaka-u.ac.jp

    2006-10-01

    It is important to remove large environmental noise in measurement using SQUIDs without magnetic shielding. Active noise control (ANC) is an effective method to remove the environmental noise. The environmental noise has been reduced by the ANC system in the radio frequency region around MHz. The anti-phase waves of the environmental noise should be generated by this system. The ANC system including the phase and amplitude control circuit was developed to make the anti-phase waves in the MHz region. In this paper, sinusoidal waves with a MHz frequency were used as the environmental noise. When a coil antenna was used for a receiver antenna, this ANC system suppressed these sinusoidal waves to the white noise level about 40 dB. When we used a SQUID as a receiver antenna, we also cancelled sinusoidal waves to the white noise level by this system. This shows that the ANC system is useful to reduce an environmental noise when this ANC system is developed to cancel multi-frequency noise.

  9. Reduction of environmental MHz noise for SQUID application

    International Nuclear Information System (INIS)

    Araya, T.; Kitamura, Y.; Kamishiro, M.; Sakuta, K.; Itozaki, H.

    2006-01-01

    It is important to remove large environmental noise in measurement using SQUIDs without magnetic shielding. Active noise control (ANC) is an effective method to remove the environmental noise. The environmental noise has been reduced by the ANC system in the radio frequency region around MHz. The anti-phase waves of the environmental noise should be generated by this system. The ANC system including the phase and amplitude control circuit was developed to make the anti-phase waves in the MHz region. In this paper, sinusoidal waves with a MHz frequency were used as the environmental noise. When a coil antenna was used for a receiver antenna, this ANC system suppressed these sinusoidal waves to the white noise level about 40 dB. When we used a SQUID as a receiver antenna, we also cancelled sinusoidal waves to the white noise level by this system. This shows that the ANC system is useful to reduce an environmental noise when this ANC system is developed to cancel multi-frequency noise

  10. Human-Induced Effects on RSS Ranging Measurements for Cooperative Positioning

    DEFF Research Database (Denmark)

    Della Rosa, Francescantonio; Pelosi, Mauro; Nurmi, Jari

    2012-01-01

    of human-induced perturbations for enhancing the final positioning accuracy through cooperative schemes has been assessed. It has been proved that the effect of cooperation is very limited if human factors are not taken into account when performing experimental activities.......We present experimental evaluations of human-induced perturbations on received-signal-strength-(RSS-) based ranging measurements for cooperative mobile positioning. To the best of our knowledge, this work is the first attempt to gain insight and understand the impact of both body loss and hand grip...... on the RSS for enhancing proximity measurements among neighbouring devices in cooperative scenarios. Our main contribution is represented by experimental investigations. Analysis of the errors introduced in the distance estimation using path-loss-based methods has been carried out. Moreover, the exploitation...

  11. Basic Safety Considerations for Nuclear Power Plant Dealing with External Human Induced Events

    Energy Technology Data Exchange (ETDEWEB)

    Salem, W., E-mail: wafaasalem21@yahoo.com [Nuclear and Radiological Regulatory Authority (Egypt)

    2014-10-15

    Facilities and human activities in the region in which a nuclear power plant is located may under some conditions affect its safety. The potential sources of human induced events external to the plant should be identified and the severity of the possible resulting hazard phenomena should be evaluated to derive the appropriate design bases for the plant. They should also be monitored and periodically assessed over the lifetime of the plant to ensure that consistency with the design assumptions is maintained. External human induced events that could affect safety should be investigated in the site evaluation stage for every nuclear power plant site. The region is required to be examined for facilities and human activities that have the potential, under certain conditions, to endanger the nuclear power plant over its entire lifetime. Each relevant potential source is required to be identified and assessed to determine the potential interactions with personnel and plant items important to safety. (author)

  12. Human Induced Pluripotent Stem Cells as a Platform for Personalized and Precision Cardiovascular Medicine.

    Science.gov (United States)

    Matsa, Elena; Ahrens, John H; Wu, Joseph C

    2016-07-01

    Human induced pluripotent stem cells (hiPSCs) have revolutionized the field of human disease modeling, with an enormous potential to serve as paradigm shifting platforms for preclinical trials, personalized clinical diagnosis, and drug treatment. In this review, we describe how hiPSCs could transition cardiac healthcare away from simple disease diagnosis to prediction and prevention, bridging the gap between basic and clinical research to bring the best science to every patient. Copyright © 2016 the American Physiological Society.

  13. Solar noise storms

    CERN Document Server

    Elgaroy, E O

    2013-01-01

    Solar Noise Storms examines the properties and features of solar noise storm phenomenon. The book also presents some theories that can be used to gain a better understanding of the phenomenon. The coverage of the text includes topics that cover the features and behavior of noise storms, such as the observable features of noise storms; the relationship between noise storms and the observable features on the sun; and ordered behavior of storm bursts in the time-frequency plane. The book also covers the spectrum, polarization, and directivity of noise storms. The text will be of great use to astr

  14. Generation of Oligodendrogenic Spinal Neural Progenitor Cells From Human Induced Pluripotent Stem Cells.

    Science.gov (United States)

    Khazaei, Mohamad; Ahuja, Christopher S; Fehlings, Michael G

    2017-08-14

    This unit describes protocols for the efficient generation of oligodendrogenic neural progenitor cells (o-NPCs) from human induced pluripotent stem cells (hiPSCs). Specifically, detailed methods are provided for the maintenance and differentiation of hiPSCs, human induced pluripotent stem cell-derived neural progenitor cells (hiPS-NPCs), and human induced pluripotent stem cell-oligodendrogenic neural progenitor cells (hiPSC-o-NPCs) with the final products being suitable for in vitro experimentation or in vivo transplantation. Throughout, cell exposure to growth factors and patterning morphogens has been optimized for both concentration and timing, based on the literature and empirical experience, resulting in a robust and highly efficient protocol. Using this derivation procedure, it is possible to obtain millions of oligodendrogenic-NPCs within 40 days of initial cell plating which is substantially shorter than other protocols for similar cell types. This protocol has also been optimized to use translationally relevant human iPSCs as the parent cell line. The resultant cells have been extensively characterized both in vitro and in vivo and express key markers of an oligodendrogenic lineage. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley and Sons, Inc.

  15. Indirect effects of human-induced environmental change on offspring production mediated by behavioural responses.

    Science.gov (United States)

    Candolin, Ulrika; Nieminen, Anne; Nyman, Johanna

    2014-01-01

    Human-induced rapid environmental changes often cause behavioural alterations in animals. The consequences that these alterations in turn have for the viability of populations are, however, poorly known. We used a population of threespine sticklebacks Gasterosteus aculeatus in the Baltic Sea to investigate the consequences of behavioural responses to human-induced eutrophication for offspring production. The investigated population has been growing during the last decades, and one cause could be increased offspring production. We combined field-based surveys with laboratory-based experiments, and found that an enhanced growth of macroalgae relaxed agonistic interactions among males. This allowed more males to nest, improved hatching success, and increased the number of reproductive cycles that males completed. Thus, the behavioural responses were adaptive at the individual level and increased offspring production. However, a larger proportion of small males of low competitive ability reproduced in dense vegetation. As male size and dominance are heritable, this could influence the genetic composition of the offspring. Together with a higher number of offspring produced, this could influence natural selection and the rate of adaptation to the changing environment. Thus, behavioural responses to a rapid human-induced environmental change can influence offspring production, with potential consequences for population dynamics and evolutionary processes.

  16. Cross-Correlations in Quasar Radio Emission

    Science.gov (United States)

    Nefedyev, Yuri; Panischev, Oleg; Demin, Sergey

    The main factors forming the complex evolution of the accretive astrophysical systems are nonlinearity, intermittency, nonstationarity and also collective phenomena. To discover the dynamic processes in these objects and to detain understanding their properties we need to use all the applicable analyzing methods. Here we use the Flicker-Noise Spectroscopy (FNS) as a phenomenological approach to analyzing and parameterizing the auto- and cross-correlations in time series of astrophysical objects dynamics. As an example we consider the quasar flux radio spectral density at frequencies 2.7 GHz and 8.1 GHz. Data have been observed by Dr. N. Tanizuka (Laboratory for Complex Systems Analysis, Osaka Prefecture University) in a period of 1979 to 1988 (3 309 days). According to mental habits quasar is a very energetic and distant active galactic nucleus containing a supermassive black hole by size 10-10,000 times the Schwarzschild radius. The quasar is powered by an accretion disc around the black hole. The accretion disc material layers, moving around the black hole, are under the influence of gravitational and frictional forces. It results in raising the high temperature and arising the resonant and collective phenomena reflected in quasar emission dynamics. Radio emission dynamics of the quasar 0215p015 is characterized by three quasi-periodic processes, which are prevalent in considering dynamics. By contrast the 1641p399's emission dynamics have not any distinguish processes. It means the presence of high intermittency in accretive modes. The second difference moment allows comparing the degree of manifesting of resonant and chaotic components in initial time series of the quasar radio emission. The comparative analysis shows the dominating of chaotic part of 1641p399's dynamics whereas the radio emission of 0215p015 has the predominance of resonant component. Analyzing the collective features of the quasar radio emission intensity demonstrates the significant

  17. Introduction to international radio regulations

    Energy Technology Data Exchange (ETDEWEB)

    Radicella, S M [Abdus Salam International Centre for Theoretical Physics, Trieste (Italy)

    2003-12-15

    These lecture notes contain an overview of basic problems of the International Radio Regulations. Access to the existing information infrastructure, and to that of the future Information Society, depends critically on radio, especially in poor, remote and sparsely populated regions with under-developed telecommunication infrastructure. How the spectrum of radio frequencies is regulated has profound impact on the society, its security, prosperity, and culture. The radio regulations represent a very important framework for an adequate use of radio and should be known by all of those working in the field.

  18. Introduction to international radio regulations

    International Nuclear Information System (INIS)

    Radicella, S.M.

    2003-01-01

    These lecture notes contain an overview of basic problems of the International Radio Regulations. Access to the existing information infrastructure, and to that of the future Information Society, depends critically on radio, especially in poor, remote and sparsely populated regions with under-developed telecommunication infrastructure. How the spectrum of radio frequencies is regulated has profound impact on the society, its security, prosperity, and culture. The radio regulations represent a very important framework for an adequate use of radio and should be known by all of those working in the field

  19. Radio resource management in multi-tier cellular wireless networks

    CERN Document Server

    Hossain, Ekram; Niyato, Dusit

    2013-01-01

    Providing an extensive overview of the radio resource management problem in femtocell networks, this invaluable book considers both code division multiple access femtocells and orthogonal frequency-division multiple access femtocells. In addition to incorporating current research on this topic, the book also covers technical challenges in femtocell deployment, provides readers with a variety of approaches to resource allocation and a comparison of their effectiveness, explains how to model various networks using Stochastic geometry and shot noise theory, and much more.

  20. Wavelet Denoising of Radio Observations of Rotating Radio Transients (RRATs): Improved Timing Parameters for Eight RRATs

    Science.gov (United States)

    Jiang, M.; Cui, B.-Y.; Schmid, N. A.; McLaughlin, M. A.; Cao, Z.-C.

    2017-09-01

    Rotating radio transients (RRATs) are sporadically emitting pulsars detectable only through searches for single pulses. While over 100 RRATs have been detected, only a small fraction (roughly 20%) have phase-connected timing solutions, which are critical for determining how they relate to other neutron star populations. Detecting more pulses in order to achieve solutions is key to understanding their physical nature. Astronomical signals collected by radio telescopes contain noise from many sources, making the detection of weak pulses difficult. Applying a denoising method to raw time series prior to performing a single-pulse search typically leads to a more accurate estimation of their times of arrival (TOAs). Taking into account some features of RRAT pulses and noise, we present a denoising method based on wavelet data analysis, an image-processing technique. Assuming that the spin period of an RRAT is known, we estimate the frequency spectrum components contributing to the composition of RRAT pulses. This allows us to suppress the noise, which contributes to other frequencies. We apply the wavelet denoising method including selective wavelet reconstruction and wavelet shrinkage to the de-dispersed time series of eight RRATs with existing timing solutions. The signal-to-noise ratio (S/N) of most pulses are improved after wavelet denoising. Compared to the conventional approach, we measure 12%–69% more TOAs for the eight RRATs. The new timing solutions for the eight RRATs show 16%–90% smaller estimation error of most parameters. Thus, we conclude that wavelet analysis is an effective tool for denoising RRATs signal.

  1. Wavelet Denoising of Radio Observations of Rotating Radio Transients (RRATs): Improved Timing Parameters for Eight RRATs

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, M.; Schmid, N. A.; Cao, Z.-C. [Lane Department of Computer Science and Electrical Engineering West Virginia University Morgantown, WV 26506 (United States); Cui, B.-Y.; McLaughlin, M. A. [Department of Physics and Astronomy West Virginia University Morgantown, WV 26506 (United States)

    2017-09-20

    Rotating radio transients (RRATs) are sporadically emitting pulsars detectable only through searches for single pulses. While over 100 RRATs have been detected, only a small fraction (roughly 20%) have phase-connected timing solutions, which are critical for determining how they relate to other neutron star populations. Detecting more pulses in order to achieve solutions is key to understanding their physical nature. Astronomical signals collected by radio telescopes contain noise from many sources, making the detection of weak pulses difficult. Applying a denoising method to raw time series prior to performing a single-pulse search typically leads to a more accurate estimation of their times of arrival (TOAs). Taking into account some features of RRAT pulses and noise, we present a denoising method based on wavelet data analysis, an image-processing technique. Assuming that the spin period of an RRAT is known, we estimate the frequency spectrum components contributing to the composition of RRAT pulses. This allows us to suppress the noise, which contributes to other frequencies. We apply the wavelet denoising method including selective wavelet reconstruction and wavelet shrinkage to the de-dispersed time series of eight RRATs with existing timing solutions. The signal-to-noise ratio (S/N) of most pulses are improved after wavelet denoising. Compared to the conventional approach, we measure 12%–69% more TOAs for the eight RRATs. The new timing solutions for the eight RRATs show 16%–90% smaller estimation error of most parameters. Thus, we conclude that wavelet analysis is an effective tool for denoising RRATs signal.

  2. Radio-capacity of ecosystems

    International Nuclear Information System (INIS)

    Kultakhmedov, Yu.; Kultakhmedova-Vyshnyakova, V.

    1997-01-01

    This paper consider a universal approach to ecosystems of different types, based on representation of their radio-capacity. The concept of ecosystem includes reproduction of components (bio-productivity) and conditions such as maintaining of environment quality. Radio-capacity in the case of radionuclide pollution appears in accumulation and redistribution of radionuclides in the ecosystem. As a result the radionuclides are redistributed and buried in soil or lake bottom sediments. Estimation models for the radio-capacity of water and terrestrial ecosystems are represented. The calculations of the radio-capacity factor of water ecosystems are performed, and the high radio-capacity of a freshwater reservoir (F=0.6-0.8) and extremely high radio-capacity of a reservoir cascade (F c =0.99) is shown material from the Dnieper's cascade reservoirs. The methods of radio-capacity estimation of agroecosystems, wood and marine ecosystems are developed. (authors)

  3. The Concept of 'Radio Music'

    DEFF Research Database (Denmark)

    Fjeldsøe, Michael

    2016-01-01

    , educational and didactic effort which would enlighten all of society. For a while it seemed that radio music was considered a genre of its own. To fulfil its function, radio music had to consider technical limitations as well as the educational level and listening modes of the new mass audience. Public radio......, as discussed by Kurt Weill and Paul Hindemith, was at first greeted with great expectations, but soon a more realistic attitude prevailed. Weill, himself a radio critic as well, composed Der Lindberghflug (1929) as a piece of ‘radio music theatre’, but then changed some of its features in order to turn...... it into a didactical play for amateurs, a so-called Lehrstück. The article will present the concept of ‘radio music’ developed within German Neue Sachlichkeit and discuss the relevance of such a concept for current research in the field of radio and music....

  4. NASA Jet Noise Research

    Science.gov (United States)

    Henderson, Brenda

    2016-01-01

    The presentation highlights NASA's jet noise research for 2016. Jet-noise modeling efforts, jet-surface interactions results, acoustic characteristics of multi-stream jets, and N+2 Supersonic Aircraft system studies are presented.

  5. Tools of radio astronomy

    CERN Document Server

    Wilson, Thomas L; Hüttemeister, Susanne

    2009-01-01

    The recent years have seen breathtaking progress in technology, especially in the receiver and digital technologies relevant for radio astronomy, which has at the same time advanced to shorter wavelengths. This is the updated and completely revised 5th edition of the most used introductory text in radio astronomy. It presents a unified treatment of the entire field from centimeter to sub-millimeter wavelengths. Topics covered include instruments, sensitivity considerations, observational methods and interpretations of the data recorded with both single dishes and interferometers. This text is useful to both students and experienced practicing astronomers. Besides making major updates and additions throughout the book, the authors have re-organized a number of chapters to more clearly separate basic theory from rapidly evolving practical aspects. Further, problem sets have been added at the end of each chapter.

  6. Radio telescope control

    CERN Document Server

    Schraml, J

    1972-01-01

    An on-line computer control process developed for the 100-m radio telescope of the Max-Planck-Institut fur Radioastronomie in Bonn is described. The instrument is the largest fully steerable antenna in the world. Its operation started on May 31st 1972. It is controlled by a Ferranti Argus 500 on-line computer. The first part of the paper deals with the process itself, the radio telescope and its operation, and the demands resulting for the control program. The second part briefly describes the computer and its hardware. The final part introduces the architecture of the executive program in general, which has been tailored to meet the demands of the process and the hardware. The communication between the observer and the system, the format of data on magnetic tape and an on-line reduction of position measurements are considered. (0 refs).

  7. Die radio in Afrika

    Directory of Open Access Journals (Sweden)

    S. de Villiers

    1966-03-01

    Full Text Available Omvang van radio-uitsendings in en na Afrika. — Redes vir die versnelde tempo van uitbreiding. — Radio as die geskikste massa-kommunikasiemiddel vir Afrika. — Faktore wat die verspreiding bemoeilik. — Skouspelagtige toename in luistertalle.Toe Plinius, wat in die jaar 79 oorlede is, in sy „Historia Naturalis” verklaar het dat daar altyd iets nuuts uit Afrika afkomstig is, kon hy nouliks voorsien het dat die „iets" negentien eeue later in die lug sou setel wat hierdie reuse-vasteland oorspan — ’n Babelse spraakverwarring en ’n ongekende, verbete woorde-oorlog in die etergolwe, onder meer daarop bereken om die harte en hoofde van derduisendes te verower.

  8. NOAA Weather Radio

    Science.gov (United States)

    cosas afectan la recepción de señas de la radio. Por ejemplo, las extensiones grandes de agua de sal receptor con una antena interior de calidad buena, o conectarlo a una antena externa. Generalmente los Programación Español Listado de estación Explicacion de SAME Coverage Station Listing County Listing

  9. Radio Frequency Interference Mitigation

    Science.gov (United States)

    An, T.; Chen, X.; Mohan, P.; Lao, B. Q.

    2017-09-01

    The observational facilities of radio astronomy keep constant upgrades and developments to achieve better capabilities including increasing the time of the data recording and frequency resolutions, and increasing the receiving and recording bandwidth. However in contrast, only a limited spectrum resource has been allocated to radio astronomy by the International Telecommunication Union, resulting in that the radio observational instrumentations are inevitably exposed to undesirable radio frequency interference (RFI) signals which originate mainly from the terrestrial human activity and are becoming stronger with time. RFIs degrade the quality of data and even lead to invalid data. The impact of RFIs on scientific outcome becomes more and more serious. In this article, the requirement for RFI mitigation is motivated, and the RFI characteristics, mitigation techniques, and strategies are reviewed. The mitigation strategies adopted at some representative observatories, telescopes, and arrays are also introduced. The advantages and shortcomings of the four classes of RFI mitigation strategies are discussed and presented, applicable at the connected causal stages: preventive, pre-detection, pre-correlation, and post-correlation. The proper identification and flagging of RFI is the key to the reduction of data loss and improvement in data quality, and is also the ultimate goal of developing RFI mitigation technique. This can be achieved through a strategy involving a combination of the discussed techniques in stages. The recent advances in the high speed digital signal processing and high performance computing allow for performing RFI excision of the large data volumes generated from large telescopes or arrays in both real time and offline modes, aiding the proposed strategy.

  10. Noise Reduction Techniques

    Science.gov (United States)

    Hallas, Tony

    There are two distinct kinds of noise - structural and color. Each requires a specific method of attack to minimize. The great challenge is to reduce the noise without reducing the faint and delicate detail in the image. My most-used and favorite noise suppression is found in Photoshop CS 5 Camera Raw. If I cannot get the desired results with the first choice, I will use Noise Ninja, which has certain advantages in some situations that we will cover.

  11. Noise Gating Solar Images

    Science.gov (United States)

    DeForest, Craig; Seaton, Daniel B.; Darnell, John A.

    2017-08-01

    I present and demonstrate a new, general purpose post-processing technique, "3D noise gating", that can reduce image noise by an order of magnitude or more without effective loss of spatial or temporal resolution in typical solar applications.Nearly all scientific images are, ultimately, limited by noise. Noise can be direct Poisson "shot noise" from photon counting effects, or introduced by other means such as detector read noise. Noise is typically represented as a random variable (perhaps with location- or image-dependent characteristics) that is sampled once per pixel or once per resolution element of an image sequence. Noise limits many aspects of image analysis, including photometry, spatiotemporal resolution, feature identification, morphology extraction, and background modeling and separation.Identifying and separating noise from image signal is difficult. The common practice of blurring in space and/or time works because most image "signal" is concentrated in the low Fourier components of an image, while noise is evenly distributed. Blurring in space and/or time attenuates the high spatial and temporal frequencies, reducing noise at the expense of also attenuating image detail. Noise-gating exploits the same property -- "coherence" -- that we use to identify features in images, to separate image features from noise.Processing image sequences through 3-D noise gating results in spectacular (more than 10x) improvements in signal-to-noise ratio, while not blurring bright, resolved features in either space or time. This improves most types of image analysis, including feature identification, time sequence extraction, absolute and relative photometry (including differential emission measure analysis), feature tracking, computer vision, correlation tracking, background modeling, cross-scale analysis, visual display/presentation, and image compression.I will introduce noise gating, describe the method, and show examples from several instruments (including SDO

  12. AIDS radio triggers.

    Science.gov (United States)

    Elias, A M

    1991-07-01

    In April 1991, the Ethnic Communities' Council of NSW was granted funding under the Community AIDS Prevention and Education Program through the Department of Community Services and Health, to produce a series of 6x50 second AIDS radio triggers with a 10-second tag line for further information. The triggers are designed to disseminate culturally-sensitive information about HIV/AIDS in English, Italian, Greek, Spanish, Khmer, Turkish, Macedonian, Serbo-Croatian, Arabic, Cantonese, and Vietnamese, with the goal of increasing awareness and decreasing the degree of misinformation about HIV/AIDS among people of non-English-speaking backgrounds through radio and sound. The 6 triggers cover the denial that AIDS exists in the community, beliefs that words and feelings do not protect one from catching HIV, encouraging friends to be compassionate, compassion within the family, AIDS information for a young audience, and the provision of accurate and honest information on HIV/AIDS. The triggers are slated to be completed by the end of July 1991 and will be broadcast on all possible community, ethnic, and commercial radio networks across Australia. They will be available upon request in composite form with an information kit for use by health care professionals and community workers.

  13. Aircrafts' taxi noise emission

    NARCIS (Netherlands)

    Asensio, C.; Pagan Munoz, Raul; López, J.M.

    2008-01-01

    An investigation has been conducted, with the objective of creating a database of inputs that can be used with noise prediction software, to evaluate noise of aircraft taxing movements and community noise exposure levels. The acoustic consultant can use these data with any of the software packages,

  14. Classical noise, quantum noise and secure communication

    International Nuclear Information System (INIS)

    Tannous, C; Langlois, J

    2016-01-01

    Secure communication based on message encryption might be performed by combining the message with controlled noise (called pseudo-noise) as performed in spread-spectrum communication used presently in Wi-Fi and smartphone telecommunication systems. Quantum communication based on entanglement is another route for securing communications as demonstrated by several important experiments described in this work. The central role played by the photon in unifying the description of classical and quantum noise as major ingredients of secure communication systems is highlighted and described on the basis of the classical and quantum fluctuation dissipation theorems. (review)

  15. Active noise control in a duct to cancel broadband noise

    Science.gov (United States)

    Chen, Kuan-Chun; Chang, Cheng-Yuan; Kuo, Sen M.

    2017-09-01

    The paper presents cancelling duct noises by using the active noise control (ANC) techniques. We use the single channel feed forward algorithm with feedback neutralization to realize ANC. Several kinds of ducts noises including tonal noises, sweep tonal signals, and white noise had investigated. Experimental results show that the proposed ANC system can cancel these noises in a PVC duct very well. The noise reduction of white noise can be up to 20 dB.

  16. Observations of a post-flare radio burst in X-rays

    Science.gov (United States)

    Svestka, Z.; Hoyng, P.; Van Tend, W.; Boelee, A.; De Jager, C.; Stewart, R. T.; Acton, L. W.; Bruner, E. C.; Gabriel, A. H.; Rapley, C. G.

    1982-01-01

    More than six hours after the two-ribbon flare of May 21, 1980, the hard X-ray spectrometer aboard the SMM imaged an extensive arch above the flare region which was found to be the lowest part of a stationary post-flare noise storm recorded at the same time at Culgoora. The bent crystal spectrometer aboard the SMM confirms that the arch emission was basically thermal. Variations in brightness and energy spectrum at one of the supposed footpoints of the arch are seen as correlation in time with radio brightness, suggesting that suprathermal particles from the radio noise regions dumped in variable quantities onto the low corona and transition layer.

  17. Combat aircraft noise

    Science.gov (United States)

    Sgarbozza, M.; Depitre, A.

    1992-04-01

    A discussion of the characteristics and the noise levels of combat aircraft and of a transport aircraft in taking off and landing are presented. Some methods of noise reduction are discussed, including the following: operational anti-noise procedures; and concepts of future engines (silent post-combustion and variable cycle). Some measurement results concerning the noise generated in flight at great speeds and low altitude will also be examined. Finally, the protection of the environment of French air bases against noise will be described and the possibilities of regulation examined.

  18. Direct-reading dial for noise temperature and noise resistance

    DEFF Research Database (Denmark)

    Diamond, J.M.

    1967-01-01

    An attenuator arrangement for a noise generator is described. The scheme permits direct reading of both noise resistance and noise temperature¿the latter with a choice of source resistance.......An attenuator arrangement for a noise generator is described. The scheme permits direct reading of both noise resistance and noise temperature¿the latter with a choice of source resistance....

  19. Noise suppression in duct

    International Nuclear Information System (INIS)

    Ahmed, A.; Barfeh, M.A.G.

    2001-01-01

    In air-conditioning system the noise generated by supply fan is carried by conditioned air through the ductwork. The noise created in ductwork run may be transmission, regenerative and ductborne. Transmission noise is fan noise, regenerative noise is due to turbulence in flow and ductborne noise is the noise radiating from duct to surroundings. Some noise is attenuated in ducts also but if noise level is high then it needs to be attenuated. A simple mitre bend can attenuate-noise. This principle is extended to V and M-shape ducts with inside lining of fibreglass, which gave maximum attenuation of 77 dB and 62 dB respectively corresponding to 8 kHz frequency as compared to mitre, bend giving maximum 18 dB attenuation. Sound level meter measured sound levels with octave band filter and tests were conducted in anechoic room. A V-shape attenuator can be used at fan outlet and high frequency noise can be minimized greatly. (author)

  20. Electromagnetic noise spectrum at John TS [transmission station

    International Nuclear Information System (INIS)

    Hatanaka, G.K.

    1992-01-01

    Canadian National (CN) is proposing the development of a commercial office tower on a site directly south of John Transmission Station (TS). CN is concerned about the potential effects of fields originating from John TS and other nearby sources on the operation of sensitive equipment and occupants of the building. Potential equipment and tenants might include data processing equipment and television and radio broadcasting companies. A study was conducted to characterize the severity of the electromagnetic environment at the site in order to address these concerns. Measurements of the electromagnetic spectrum from 100 kHz to 300 MHz were performed from a mobile test facility that features a 5 kW diesel generator and an extendible antenna mast. Peak measurements were made using a selectable measurement time of 0.05 s. It was found that the highest noise levels result from micro-gap discharges under dry weather conditions. The micro-gap discharges are characteristic of defect noise sources associated with substation hardware. At 0.5 MHz the noise levels are typical of median noise levels expected for the International Radio Consultive Committee (CCIR) defined business environment. At 74 MHz the noise levels are more severe than the expected levels for this type of environment. However, levels more representative of the business environment will be achieved by eliminating the micro-gap noise sources attributed to John TS. 6 refs., 11 figs., 2 tabs

  1. Active3 noise reduction

    International Nuclear Information System (INIS)

    Holzfuss, J.

    1996-01-01

    Noise reduction is a problem being encountered in a variety of applications, such as environmental noise cancellation, signal recovery and separation. Passive noise reduction is done with the help of absorbers. Active noise reduction includes the transmission of phase inverted signals for the cancellation. This paper is about a threefold active approach to noise reduction. It includes the separation of a combined source, which consists of both a noise and a signal part. With the help of interaction with the source by scanning it and recording its response, modeling as a nonlinear dynamical system is achieved. The analysis includes phase space analysis and global radial basis functions as tools for the prediction used in a subsequent cancellation procedure. Examples are given which include noise reduction of speech. copyright 1996 American Institute of Physics

  2. A low-frequency radio survey of the planets with RAE 2

    Science.gov (United States)

    Kaiser, M. L.

    1977-01-01

    Over one thousand occultations of each planet in the solar system have occurred during the period from mid-1973 through mid-1976 as seen from the lunar orbiting Radio Astronomy Explorer 2 (RAE 2) spacecraft. These occultations have been examined for evidence of planetary radio emissions in the 0.025-13.1 MHz band. Only Jupiter and the earth have given positive results. Lack of detection of emission from the other planets can mean that either they do not emit radio noise in this band or the flux level of their emissions and/or its occurrence rate are too low to be detected by RAE 2.

  3. A low-frequency radio survey of the planets with RAE-2

    International Nuclear Information System (INIS)

    Kaiser, M.L.

    1976-08-01

    Over one thousand occultations of each planet in the solar system have occurred during the period from mid-1973 through mid-1976 as seen from the lunar orbiting Radio Astronomy Explorer-2 (RAE-2) spacecraft. These occultations have been examined for evidence of planetary radio emissions in the 0.025 to 13.1 MHz band. Only Jupiter and the earth have given positive results. Lack of detection of emission from the other planets can mean that either they do not emit radio noise in this band or the flux level of their emissions and/or its occurrence rate are too low to be detected by RAE-2

  4. A low-frequency radio survey of the planets with RAE-2

    Science.gov (United States)

    Kaiser, M. L.

    1976-01-01

    Over one thousand occultations of each planet in the solar system have occurred during the period from mid-1973 through mid-1976 as seen from the lunar orbiting Radio Astronomy Explorer-2 (RAE-2) spacecraft. These occultations have been examined for evidence of planetary radio emissions in the 0.025 to 13.1 MHz band. Only Jupiter and the earth have given positive results. Lack of detection of emission from the other planets can mean that either they do not emit radio noise in this band or the flux level of their emissions and/or its occurrence rate are too low to be detected by RAE-2.

  5. A low-frequency radio survey of the planets with RAE 2

    International Nuclear Information System (INIS)

    Kaiser, M.L.

    1977-01-01

    Over one thousand occultations of each planet in the solar system have occurred during the period from mid-1973 through mid-1976 as seen from the lunar orbiting Radio Astronomy Explorer 2 (RAE 29) spacecraft. These occultations have been examined for evidence of planetary radio emissions in the 0.025--13.1 MHz band. Only Jupiter and the earth have given positive results. Lack of detection of emission from the other planets can mean that either they do not emit radio noise in this band or the flux level of their emissions and/or its occurrence rate are too low to be detected by RAE 2

  6. A RADIO-LOUD MAGNETAR IN X-RAY QUIESCENCE

    International Nuclear Information System (INIS)

    Levin, Lina; Bailes, Matthew; Bhat, N. D. Ramesh; Burke-Spolaor, Sarah; Van Straten, Willem; Bates, Samuel; Kramer, Michael; Stappers, Ben; Burgay, Marta; D'Amico, Nichi; Milia, Sabrina; Possenti, Andrea; Johnston, Simon; Keith, Michael; Rea, Nanda

    2010-01-01

    As part of a survey for radio pulsars with the Parkes 64 m telescope, we have discovered PSR J1622-4950, a pulsar with a 4.3 s rotation period. Follow-up observations show that the pulsar has the highest inferred surface magnetic field of the known radio pulsars (B ∼3 x 10 14 G), and it exhibits significant timing noise and appears to have an inverted spectrum. Unlike the vast majority of the known pulsar population, PSR J1622-4950 appears to switch off for many hundreds of days and even in its on-state exhibits extreme variability in its flux density. Furthermore, the integrated pulse profile changes shape with epoch. All of these properties are remarkably similar to the only two magnetars previously known to emit radio pulsations. The position of PSR J1622-4950 is coincident with an X-ray source that, unlike the other radio pulsating magnetars, was found to be in quiescence. We conclude that our newly discovered pulsar is a magnetar-the first to be discovered via its radio emission.

  7. Noise from wind turbines

    Energy Technology Data Exchange (ETDEWEB)

    Fegeant, Olivier [Royal Inst. of Tech., Stockholm (Sweden). Dept. of Building Sciences

    2002-02-01

    A rapid growth of installed wind power capacity is expected in the next few years. However, the siting of wind turbines on a large scale raises concerns about their environmental impact, notably with respect to noise. To this end, variable speed wind turbines offer a promising solution for applications in densely populated areas like the European countries, as this design would enable an efficient utilisation of the masking effect due to ambient noise. In rural and recreational areas where wind turbines are sited, the ambient noise originates from the action of wind on the vegetation and about the listener's ear (pseudo-noise). It shows a wind speed dependence similar to that of the noise from a variable speed wind turbine and can therefore mask the latter for a wide range of conditions. However, a problem inherent to the design of these machines is their proclivity to pure tone generation, because of the enhanced difficulty of avoiding structural resonances in the mechanical parts. Pure tones are deemed highly annoying and are severely regulated by most noise policies. In relation to this problem, the vibration transmission of structure-borne sound to the tower of the turbine is investigated, in particular when the tower is stiffened at its upper end. Furthermore, since noise annoyance due to wind turbine is mostly a masking issue, the wind-related sources of ambient noise are studied and their masking potentials assessed. With this aim, prediction models for wind-induced vegetation noise and pseudo-noise have been developed. Finally, closely related to the effect of masking, is the difficulty, regularly encountered by local authorities and wind farm developers, to measure noise immission from wind turbines. A new measurement technique has thus been developed in the course of this work. Through improving the signal-to-noise ratio between wind turbine noise and ambient noise, the new technique yields more accurate measurement results.

  8. Flexible Adaptation in Cognitive Radios

    CERN Document Server

    Li, Shujun

    2013-01-01

    This book provides an introduction to software-defined radio and cognitive radio, along with methodologies for applying knowledge representation, semantic web, logic reasoning and artificial intelligence to cognitive radio, enabling autonomous adaptation and flexible signaling. Readers from the wireless communications and software-defined radio communities will use this book as a reference to extend software-defined radio to cognitive radio, using the semantic technology described. Readers with a background in semantic web and artificial intelligence will find in this book the application of semantic web and artificial intelligence technologies to wireless communications. For readers in networks and network management, this book presents a new approach to enable interoperability, collaborative optimization and flexible adaptation of network components. Provides a comprehensive ontology covering the core concepts of wireless communications using a formal language; Presents the technical realization of using a ...

  9. Profiling Saturn's rings by radio occultation

    International Nuclear Information System (INIS)

    Marouf, E.A.; Tyler, G.L.; Rosen, P.A.

    1986-01-01

    The development of reconstruction algorithms that correct for diffraction effects in radio occultation measurements is described. The reciprocal Fresnel transform relationship between the complex amplitude of the observed coherent signal and the complex microwave transmittance of the rings is derived using the Huygens-Fresnel formulation of the diffraction problem. The effects of the finite data segment width, the uncertainties in the Fresnel scale, systematic phase errors in the kernel of the inverse transform, reference oscillator instabilities, and random noise measurements on the resolution of the reconstructed transmittance are analyzed. Examples of reconstructed opacity profiles for some regions of Saturn's rings derived by applying the reconstruction theory to Voyager 1 at Saturn data are presented. 35 references

  10. First radio astronomy from space - RAE

    International Nuclear Information System (INIS)

    Kaiser, M.L.

    1987-01-01

    The spacecraft design, instrumentation, and performance of the Radio Astronomy Explorer (RAE) satellites (RAE-1 launched to earth orbit in 1968 and RAE-2 launched to lunar orbit in 1972) are reviewed and illustrated with drawings, diagrams, and graphs of typical data. Consideration is given to the three pairs of antennas, the Ryle-Vonberg and burst radiometers, and problems encountered with antenna deployment and observing patterns. Results summarized include observations of type III solar bursts, the spectral distribution of cosmic noise in broad sky regions, Jupiter at low frequencies, and auroral kilometric radiation (AKR) from the earth. The importance of avoiding the AKR bands in designing future space observatories is stressed. 11 references

  11. Human induced pluripotent stem cell-derived vascular smooth muscle cells

    DEFF Research Database (Denmark)

    Ayoubi, Sohrab; Sheikh, Søren P; Eskildsen, Tilde V

    2017-01-01

    . To this end, human induced pluripotent stem cells (hiPSCs) have generated great enthusiasm, and have been a driving force for development of novel strategies in drug discovery and regenerative cell-therapy for the last decade. Hence, investigating the mechanisms underlying the differentiation of hi......PSCs into specialized cell types such as cardiomyocytes, endothelial cells, and vascular smooth muscle cells (VSMCs) may lead to a better understanding of developmental cardiovascular processes and potentiate progress of safe autologous regenerative therapies in pathological conditions. In this review, we summarize...

  12. Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins

    OpenAIRE

    Hayato Fukusumi; Tomoko Shofuda; Yohei Bamba; Atsuyo Yamamoto; Daisuke Kanematsu; Yukako Handa; Keisuke Okita; Masaya Nakamura; Shinya Yamanaka; Hideyuki Okano; Yonehiro Kanemura

    2016-01-01

    Human neural progenitor cells (hNPCs) have previously been generated from limited numbers of human induced pluripotent stem cell (hiPSC) clones. Here, 21 hiPSC clones derived from human dermal fibroblasts, cord blood cells, and peripheral blood mononuclear cells were differentiated using two neural induction methods, an embryoid body (EB) formation-based method and an EB formation method using dual SMAD inhibitors (dSMADi). Our results showed that expandable hNPCs could be generated from hiPS...

  13. Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells

    Science.gov (United States)

    Kim, Kitai; Zhao, Rui; Doi, Akiko; Ng, Kitwa; Unternaehrer, Juli; Cahan, Patrick; Hongguang, Huo; Loh, Yuin-Han; Aryee, Martin J.; Lensch, M. William; Li, Hu; Collins, James J.; Feinberg, Andrew P.; Daley, George Q.

    2012-01-01

    We compared bona-fide human induced pluripotent stem cells (iPSC) derived from umbilical cord blood (CB) and neonatal keratinocytes (K). As a consequence of both incomplete erasure of tissue-specific methylation and aberrant de novo methylation, CB-iPSC and K-iPSC are distinct in genome-wide DNA methylation profiles and differentiation potential. Extended passage of some iPSC clones in culture didn't improve their epigenetic resemblance to ESC, implying that some human iPSC retain a residual “epigenetic memory” of their tissue of origin. PMID:22119740

  14. The Vulnerability of Earth Systems to Human-Induced Global Change and Strategies for Mitigation

    Science.gov (United States)

    Watson, R. T.

    2002-12-01

    Since the IGY, there has been growing evidence that climate is changing in response to human activities. The overwhelming majority of scientific experts, whilst recognizing that scientific uncertainties exist, nonetheless believe that human-induced climate change is inevitable. Indeed, during the last few years, many parts of the world have suffered major heat waves, floods, droughts, fires and extreme weather events leading to significant economic losses and loss of life. While individual events cannot be directly linked to human-induced climate change, the frequency and magnitude of these types of events are predicted to increase in a warmer world. The question is not whether climate will change, but rather how much (magnitude), how fast (the rate of change) and where (regional patterns). It is also clear that climate change and other human-induced modifications to the environment will, in many parts of the world, adversely affect socio-economic sectors, including water resources, agriculture, forestry, fisheries and human settlements, ecological systems (particularly forests and coral reefs), and human health (particularly diseases spread by insects), with developing countries being the most vulnerable. Environmental degradation of all types (i.e., climate change, loss of biodiversity, land degradation, air and water quality) all undermine the challenge of poverty alleviation and sustainable economic growth. One of the major challenges facing humankind is to provide an equitable standard of living for this and future generations: adequate food, water and energy, safe shelter and a healthy environment (e.g., clean air and water). Unfortunately, human-induced climate change, as well as other global environmental issues such as land degradation, loss of biological diversity and stratospheric ozone depletion, threatens our ability to meet these basic human needs. The good news is, however, that the majority of experts believe that significant reductions in net

  15. The properties of radio ellipticals

    International Nuclear Information System (INIS)

    Sparks, W.B.; Disney, M.J.; Rodgers, A.W.

    1984-01-01

    Optical and additional radio data are presented for the bright galaxies of the Disney and Wall survey (1977 Mon. Not. R. Astron. Soc. 179, 235). These data form the basis of a statistical comparison of the properties of radio elliptical galaxies to radio-quiet ellipticals. The correlations may be explained by the depth of the gravitational potential well in which the galaxy resides governing the circumstances under which an elliptical galaxy rids itself of internally produced gas. (author)

  16. Central radio sources

    International Nuclear Information System (INIS)

    Phinney, E.S.

    1985-01-01

    The compact radio sources in the nuclei of most active galaxies lie closer to their centers of activity than any other region accessible to observation, excepting only the broad emission line region. They provide uniquely strong evidence for bulk motion of matter at relativistic velocities, encouraging the belief that the activity originates in a gravitational potential well whose escape velocity is of the order of the speed of light. The observational facts are reviewed as well as several theoretical pictures of them. Those places where systematic observations could help to distinguish the true theoretical picture from the many competing forgeries are emphasized. 76 references

  17. Judgments of aircraft noise in a traffic noise background

    Science.gov (United States)

    Powell, C. A.; Rice, C. G.

    1975-01-01

    An investigation was conducted to determine subjective response to aircraft noise in different road traffic backgrounds. In addition, two laboratory techniques for presenting the aircraft noise with the background noise were evaluated. For one technique, the background noise was continuous over an entire test session; for the other, the background noise level was changed with each aircraft noise during a session. Subjective response to aircraft noise was found to decrease with increasing background noise level, for a range of typical indoor noise levels. Subjective response was found to be highly correlated with the Noise Pollution Level (NPL) measurement scale.

  18. Radio Frequency Anechoic Chamber Facility

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Supports the design, manufacture, and test of antenna systems. The facility is also used as an electromagnetic compatibility/radio frequency interference...

  19. The Hartebeeshoek Radio Astronomy Observatory

    International Nuclear Information System (INIS)

    Nicolson, G.D.

    1986-01-01

    This article briefly discusses the questions, problems and study fields of the modern astronomer. Radioastronomy has made important contributions to the study of the evolution of stars and has given much information on the birth of stars while at the other extreme, studies of neutron stars and the radio emission from the remnants of supernova explosions have given further insight into the death of individual stars. Radio astronomical studies have learned astronomers much about the structure of the Milky way and some twenty years ago, in a search for new radio galaxies, quasars were discovered. Radioastronomy research in South Africa is carried out at the Hartebeesthoek Radio Astronomy Observatory

  20. assessment of noise pollutio noise pollutio noise pollution

    African Journals Online (AJOL)

    eobe

    re above the recommended limit of 85 dB(A) and these high noise intensit related health ... multiple workplaces i.e. steel pipe and a unit factory ... construction material. However .... selected workers, particularly the machine operators. In some ...

  1. Dramatugi Penyiar Radio

    Directory of Open Access Journals (Sweden)

    Hastika Yanti Nora

    2009-07-01

    Full Text Available Dramaturgy is the work of Erving Goffman. He wrote "Presentation of Self in Everyday Life" in '1959. Following the theatrical analogy, Goffman spoke of a front stage and back stage. The front stage is that part of the performance that generally functions in rather fixed and general ways to define the situation for those who observed the performance. The back stage is situation where facts suppressed in the front or various kinds of informal actions may appear. A back stage is usually adjacent to the front stage, but it also cut off from it. Everyone in this world have to run his role in their everyday life. It also a radio announcer. As an actor, they have to be a nice and friendy person when they perform to make air personality, that is  a good  impression, from their audience. But before their perform in the front stage, there so much to do to prepare in the backstage. The front and back stage is radio announcer dramaturgy.

  2. Behavioural responses to human-induced change: Why fishing should not be ignored.

    Science.gov (United States)

    Diaz Pauli, Beatriz; Sih, Andrew

    2017-03-01

    Change in behaviour is usually the first response to human-induced environmental change and key for determining whether a species adapts to environmental change or becomes maladapted. Thus, understanding the behavioural response to human-induced changes is crucial in the interplay between ecology, evolution, conservation and management. Yet the behavioural response to fishing activities has been largely ignored. We review studies contrasting how fish behaviour affects catch by passive (e.g., long lines, angling) versus active gears (e.g., trawls, seines). We show that fishing not only targets certain behaviours, but it leads to a multitrait response including behavioural, physiological and life-history traits with population, community and ecosystem consequences. Fisheries-driven change (plastic or evolutionary) of fish behaviour and its correlated traits could impact fish populations well beyond their survival per se , affecting predation risk, foraging behaviour, dispersal, parental care, etc., and hence numerous ecological issues including population dynamics and trophic cascades . In particular, we discuss implications of behavioural responses to fishing for fisheries management and population resilience. More research on these topics, however, is needed to draw general conclusions, and we suggest fruitful directions for future studies.

  3. Some international perspectives on legislation for the management of human-induced safety risks

    Directory of Open Access Journals (Sweden)

    Alfonso Niemand

    2016-01-01

    Full Text Available Legislation that governs the health and safety of communities near major-hazard installations in South Africa is largely based on existing legislation that had been developed in the United Kingdom and other European Union countries. The latter was developed as a consequence of several major human-induced technological disasters in Europe. The history of the evolution of health-and-safety legislation for the protection of vulnerable communities in European Union (EU countries, France, Malaysia and the USA is explored through a literature survey. A concise comparison is drawn between EU countries, the USA and South Africa to obtain an exploratory view of whether current South-African legislation represents an optimum model for the protection of the health-and-safety of workers and communities near major-hazard installations. The authors come to the conclusion that South-African legislation needs revision as was done in the UK in 2011. Specific areas in the legislation that need revision are an overlap between occupational health and safety and environmental legislation, appropriate land-use planning for the protection of communities near major-hazard installations, the inclusion of vulnerability studies and the refinement of appropriate decision-making instruments such as risk assessment. This article is the first in a series that forms part of a broader study aimed at the development of an optimised model for the regulatory management of human-induced health and safety risks associated with hazardous installations in South Africa.

  4. Poultry Plant Noise Control

    Science.gov (United States)

    1982-01-01

    A demonstration conducted last winter at the Tip Top Poultry Plant intended to show poultry plant managers from all over the U.S. potential solutions to the problem of plant noise. Plastic covers used over sound absorbing materials need to meet cleanability requirements, high- pressure water cleaning and other harsh maintenance procedures peculiar to the poultry processing industry. For the demonstration, Fiber Flex, Inc. manufactured and donated 750 noise panels; Owens-Corning Fiberglas Corporation donated the fiberglas cores; and the cover material was purchased from Howe and Bainbridge. The Engineering Experiment Station (EES) conducted before and after noise surveys and is evaluating the effect of noise reduction on turnover and productivity in the demonstration plant. EES plans to conduct a noise abatement workshop and update a handbook to help poultry processors with noise problems. EES study and demonstration may be applicable to other food processing plants where similar sanitary constraints exist.

  5. Adaptive noise cancellation

    International Nuclear Information System (INIS)

    Akram, N.

    1999-01-01

    In this report we describe the concept of adaptive noise canceling, an alternative method of estimating signals corrupted by additive noise of interference. The method uses 'primary' input containing the corrupted signal and a 'reference' input containing noise correlated in some unknown way with the primary noise, the reference input is adaptively filtered and subtracted from the primary input to obtain the signal estimate. Adaptive filtering before subtraction allows the treatment of inputs that are deterministic or stochastic, stationary or time variable. When the reference input is free of signal and certain other conditions are met then noise in the primary input can be essentially eliminated without signal distortion. It is further shown that the adaptive filter also acts as notch filter. Simulated results illustrate the usefulness of the adaptive noise canceling technique. (author)

  6. BROADBAND RADIO POLARIMETRY AND FARADAY ROTATION OF 563 EXTRAGALACTIC RADIO SOURCES

    International Nuclear Information System (INIS)

    Anderson, C. S.; Gaensler, B. M.; Feain, I. J.; Franzen, T. M. O.

    2015-01-01

    We present a broadband spectropolarimetric survey of 563 discrete, mostly unresolved radio sources between 1.3 and 2.0 GHz using data taken with the Australia Telescope Compact Array. We have used rotation-measure synthesis to identify Faraday-complex polarized sources, those objects whose frequency-dependent polarization behavior indicates the presence of material possessing complicated magnetoionic structure along the line of sight (LOS). For sources classified as Faraday-complex, we have analyzed a number of their radio and multiwavelength properties to determine whether they differ from Faraday-simple polarized sources (sources for which LOS magnetoionic structures are comparatively simple) in these properties. We use this information to constrain the physical nature of the magnetoionic structures responsible for generating the observed complexity. We detect Faraday complexity in 12% of polarized sources at ∼1′ resolution, but we demonstrate that underlying signal-to-noise limitations mean the true percentage is likely to be significantly higher in the polarized radio source population. We find that the properties of Faraday-complex objects are diverse, but that complexity is most often associated with depolarization of extended radio sources possessing a relatively steep total intensity spectrum. We find an association between Faraday complexity and LOS structure in the Galactic interstellar medium (ISM) and claim that a significant proportion of the Faraday complexity we observe may be generated at interfaces of the ISM associated with ionization fronts near neutral hydrogen structures. Galaxy cluster environments and internally generated Faraday complexity provide possible alternative explanations in some cases

  7. Noise pollution alters ecological services: enhanced pollination and disrupted seed dispersal

    Science.gov (United States)

    Francis, Clinton D.; Kleist, Nathan J.; Ortega, Catherine P.; Cruz, Alexander

    2012-01-01

    Noise pollution is a novel, widespread environmental force that has recently been shown to alter the behaviour and distribution of birds and other vertebrates, yet whether noise has cumulative, community-level consequences by changing critical ecological services is unknown. Herein, we examined the effects of noise pollution on pollination and seed dispersal and seedling establishment within a study system that isolated the effects of noise from confounding stimuli common to human-altered landscapes. Using observations, vegetation surveys and pollen transfer and seed removal experiments, we found that effects of noise pollution can reverberate through communities by disrupting or enhancing these ecological services. Specifically, noise pollution indirectly increased artificial flower pollination by hummingbirds, but altered the community of animals that prey upon and disperse Pinus edulis seeds, potentially explaining reduced P. edulis seedling recruitment in noisy areas. Despite evidence that some ecological services, such as pollination, may benefit indirectly owing to noise, declines in seedling recruitment for key-dominant species such as P. edulis may have dramatic long-term effects on ecosystem structure and diversity. Because the extent of noise pollution is growing, this study emphasizes that investigators should evaluate the ecological consequences of noise alongside other human-induced environmental changes that are reshaping human-altered landscapes worldwide. PMID:22438504

  8. Noise pollution alters ecological services: enhanced pollination and disrupted seed dispersal.

    Science.gov (United States)

    Francis, Clinton D; Kleist, Nathan J; Ortega, Catherine P; Cruz, Alexander

    2012-07-22

    Noise pollution is a novel, widespread environmental force that has recently been shown to alter the behaviour and distribution of birds and other vertebrates, yet whether noise has cumulative, community-level consequences by changing critical ecological services is unknown. Herein, we examined the effects of noise pollution on pollination and seed dispersal and seedling establishment within a study system that isolated the effects of noise from confounding stimuli common to human-altered landscapes. Using observations, vegetation surveys and pollen transfer and seed removal experiments, we found that effects of noise pollution can reverberate through communities by disrupting or enhancing these ecological services. Specifically, noise pollution indirectly increased artificial flower pollination by hummingbirds, but altered the community of animals that prey upon and disperse Pinus edulis seeds, potentially explaining reduced P. edulis seedling recruitment in noisy areas. Despite evidence that some ecological services, such as pollination, may benefit indirectly owing to noise, declines in seedling recruitment for key-dominant species such as P. edulis may have dramatic long-term effects on ecosystem structure and diversity. Because the extent of noise pollution is growing, this study emphasizes that investigators should evaluate the ecological consequences of noise alongside other human-induced environmental changes that are reshaping human-altered landscapes worldwide.

  9. Acceptable noise level

    DEFF Research Database (Denmark)

    Olsen, Steen Østergaard; Nielsen, Lars Holme; Lantz, Johannes

    2012-01-01

    The acceptable noise level (ANL) is used to quantify the amount of background noise that subjects can accept while listening to speech, and is suggested for prediction of individual hearing-aid use. The aim of this study was to assess the repeatability of the ANL measured in normal-hearing subjects...... using running Danish and non-semantic speech materials as stimuli and modulated speech-spectrum and multi-talker babble noises as competing stimuli....

  10. Noise at the Interface

    DEFF Research Database (Denmark)

    Prior, Andrew

    2011-01-01

    The notion of noise occupies a contested territory, in which it is framed as pollution and detritus even as it makes its opposite a possibility - noise is always defined in opposition to something else, even if this ‘other’ is not quite clear. This paper explores noise in the context of ‘the...... interface’ asking what its affordances as an idea may contribute to our understanding of interface. I draw historically on information theory in particular to initiate this exploration....

  11. Acceptable noise level

    DEFF Research Database (Denmark)

    Olsen, Steen Østergaard; Nielsen, Lars Holme; Lantz, Johannes

    2012-01-01

    The acceptable noise level (ANL) is used to quantify the amount of background noise that subjects can accept while listening to speech, and is suggested for prediction of individual hearing-aid use. The aim of this study was to assess the repeatability of the ANL measured in normal-hearing subjec...... using running Danish and non-semantic speech materials as stimuli and modulated speech-spectrum and multi-talker babble noises as competing stimuli....

  12. Noise upon the Sinusoids

    DEFF Research Database (Denmark)

    Jensen, Karl Kristoffer

    2005-01-01

    Sinusoids are used for making harmonic and other sounds. In order to having life in the sounds and adding a wide variety of noises, irregularities are inserted in the frequency and amplitudes. A simple and intuitive noise model is presented, consisting of a low-pass filtered noise, and having...... control for strength and bandwidth. The noise is added on the frequency and amplitudes of the sinusoids, and the resulting irregularity’s (jitter and shimmer) bandwidth is derived. This, together with an overview of investigation methods of the jitter and shimmer results in an analysis of the necessary...

  13. Understanding jet noise.

    Science.gov (United States)

    Karabasov, S A

    2010-08-13

    Jets are one of the most fascinating topics in fluid mechanics. For aeronautics, turbulent jet-noise modelling is particularly challenging, not only because of the poor understanding of high Reynolds number turbulence, but also because of the extremely low acoustic efficiency of high-speed jets. Turbulent jet-noise models starting from the classical Lighthill acoustic analogy to state-of-the art models were considered. No attempt was made to present any complete overview of jet-noise theories. Instead, the aim was to emphasize the importance of sound generation and mean-flow propagation effects, as well as their interference, for the understanding and prediction of jet noise.

  14. Landing gear noise attenuation

    Science.gov (United States)

    Moe, Jeffrey W. (Inventor); Whitmire, Julia (Inventor); Kwan, Hwa-Wan (Inventor); Abeysinghe, Amal (Inventor)

    2011-01-01

    A landing gear noise attenuator mitigates noise generated by airframe deployable landing gear. The noise attenuator can have a first position when the landing gear is in its deployed or down position, and a second position when the landing gear is in its up or stowed position. The noise attenuator may be an inflatable fairing that does not compromise limited space constraints associated with landing gear retraction and stowage. A truck fairing mounted under a truck beam can have a compliant edge to allow for non-destructive impingement of a deflected fire during certain conditions.

  15. Tuning in to pavement radio

    NARCIS (Netherlands)

    Ellis, S.

    1989-01-01

    This article describes a phenomenon known all over Africa, for which there is no really satisfactory term in English but which is summed up in the French term 'radio trottoir', literally 'pavement radio'. It may be defined as the popular and unofficial discussion of current affairs in Africa,

  16. Wide Field Radio Transient Surveys

    Science.gov (United States)

    Bower, Geoffrey

    2011-04-01

    The time domain of the radio wavelength sky has been only sparsely explored. Nevertheless, serendipitous discovery and results from limited surveys indicate that there is much to be found on timescales from nanoseconds to years and at wavelengths from meters to millimeters. These observations have revealed unexpected phenomena such as rotating radio transients and coherent pulses from brown dwarfs. Additionally, archival studies have revealed an unknown class of radio transients without radio, optical, or high-energy hosts. The new generation of centimeter-wave radio telescopes such as the Allen Telescope Array (ATA) will exploit wide fields of view and flexible digital signal processing to systematically explore radio transient parameter space, as well as lay the scientific and technical foundation for the Square Kilometer Array. Known unknowns that will be the target of future transient surveys include orphan gamma-ray burst afterglows, radio supernovae, tidally-disrupted stars, flare stars, and magnetars. While probing the variable sky, these surveys will also provide unprecedented information on the static radio sky. I will present results from three large ATA surveys (the Fly's Eye survey, the ATA Twenty CM Survey (ATATS), and the Pi GHz Survey (PiGSS)) and several small ATA transient searches. Finally, I will discuss the landscape and opportunities for future instruments at centimeter wavelengths.

  17. Noise Budget and Interstellar Medium Mitigation Advances in the NANOGrav Pulsar Timing Array

    Science.gov (United States)

    Dolch, T.; NANOGrav Collaboration; Chatterjee, S.; Cordes, J. M.; Demorest, P. B.; Ellis, J. A.; Jones, M. L.; Lam, M. T.; Lazio, T. J. W.; Levin, L.; McLaughlin, M. A.; Palliyaguru, N. T.; Stinebring, D. R.

    2018-02-01

    Gravitational wave (GW) detection with pulsar timing arrays (PTAs) requires accurate noise characterization. The noise of our Galactic-scale GW detector has been systematically evaluated by the Noise Budget and Interstellar Medium Mitigation working groups within the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) collaboration. Intrinsically, individual radio millisecond pulsars (MSPs) used by NANOGrav can have some degree of achromatic red spin noise, as well as white noise due to pulse phase jitter. Along any given line-of-sight, the ionized interstellar medium contributes chromatic noise through dispersion measure (DM) variations, interstellar scintillation, and scattering. These effects contain both red and white components. In the future, with wideband receivers, the effects of frequency-dependent DM will become important. Having anticipated and measured these diverse sources of detector noise, the NANOGrav PTA remains well-poised to detect low-frequency GWs.

  18. Reduced impact of induced gate noise on inductively degenerated LNAs in deep submicron CMOS technologies

    DEFF Research Database (Denmark)

    Rossi, P.; Svelto, F.; Mazzanti, A.

    2005-01-01

    Designers of radio-frequency inductively-degenerated CMOS low-noise-amplifiers have usually not followed the guidelines for achieving minimum noise figure. Nonetheless, state-of-the- art implementations display noise figure values very close to the theoretical minimum. In this paper, we point out...... that this is due to the effect of the parasitic overlap capacitances in the MOS device. In particular, we show that overlap capacitances lead to a significant induced-gate-noise reduction, especially when deep sub-micron CMOS processes are used....

  19. Quasi-periodic oscillations and noise in low-mass X-ray binaries

    International Nuclear Information System (INIS)

    Van der Klis, M.

    1989-01-01

    The phenomenology of quasi-periodic oscillations (QPOs) and noise in low-mass X-ray binaries (LMXBs) is discussed. Signal analysis aspects of QPO and noise are addressed along with the relationship between LMXBs and millisecond radio pulsars. The history and prehistory of QPOs and noise in LMXBs are examined. Universal noise components and normal and flaring branch QPOs in Z sources are described and the phenomenology of Z sources is discussed. Bright LMXBs known as atoll sources are considered, as are nonpersistently bright LMXBs accreting pulsars and black hole candidates. 162 refs

  20. CONSTRAINING RADIO EMISSION FROM MAGNETARS

    Energy Technology Data Exchange (ETDEWEB)

    Lazarus, P.; Kaspi, V. M.; Dib, R. [Department of Physics, Rutherford Physics Building, McGill University, 3600 University Street, Montreal, Quebec H3A 2T8 (Canada); Champion, D. J. [Max-Planck-Institut fuer Radioastronomie, Auf dem Huegel 69, 53121 Bonn (Germany); Hessels, J. W. T., E-mail: plazar@physics.mcgill.ca [Netherlands Institute for Radio Astronomy (ASTRON), Postbus 2, 7990 AA Dwingeloo (Netherlands)

    2012-01-10

    We report on radio observations of five magnetars and two magnetar candidates carried out at 1950 MHz with the Green Bank Telescope in 2006-2007. The data from these observations were searched for periodic emission and bright single pulses. Also, monitoring observations of magnetar 4U 0142+61 following its 2006 X-ray bursts were obtained. No radio emission was detected for any of our targets. The non-detections allow us to place luminosity upper limits of L{sub 1950} {approx}< 1.60 mJy kpc{sup 2} for periodic emission and L{sub 1950,single} {approx}< 7.6 Jy kpc{sup 2} for single pulse emission. These are the most stringent limits yet for the magnetars observed. The resulting luminosity upper limits together with previous results are discussed, as is the importance of further radio observations of radio-loud and radio-quiet magnetars.

  1. Radio observations of symbiotic stars

    Energy Technology Data Exchange (ETDEWEB)

    Wright, A E [Commonwealth Scientific and Industrial Research Organization, Epping (Australia). Div. of Radiophysics; Allen, D A

    1978-09-01

    A search for 2-cm continuum emission from 91 symbiotic stars has been undertaken using the Parkes radio telescope. Nine sources have been detected, four of which are reported for the first time. The radio spectral indices are mostly about + 0.6; these are interpreted in terms of mass loss. In two stars a portion of the radio spectrum has an index of zero, and for one of these stars (RX Puppis) this is plausibly a manifestation of the cessation of symbiotic activity that occurred about two decades ago. There is an extraordinarily good correlation between the detectability at 2cm and the presence of circumstellar dust, but not between the radio and optical domains. The importance of continued radio monitoring of HM Sagittae over the next few years is stressed.

  2. Sounds and Noises. A Position Paper on Noise Pollution.

    Science.gov (United States)

    Chapman, Thomas L.

    This position paper focuses on noise pollution and the problems and solutions associated with this form of pollution. The paper is divided into the following five sections: Noise and the Ear, Noise Measurement, III Effects of Noise, Acoustics and Action, and Programs and Activities. The first section identifies noise and sound, the beginnings of…

  3. Radio opaque gloves

    International Nuclear Information System (INIS)

    Whittaker, A.V.; Whittaker, R.E. Jr.; Goldstrom, R.A.; Shipko, F.J.

    1975-01-01

    Radiation shielding garments and accessories, such as radio-opaque gloves for surgeons, shielding against the harmful x-ray radiation in a fluoroscopic zone, are advantageously different from garments for shielding from other medical uses of x-rays. Such garments are provided with zones of differing opacity, whereby desired sensitivity and ''feel'' through the glove material is retained. One feature is the provision of an ''opacity gradient'' across the glove cross section with opacity being relatively low at the fingertip area (lesser shield-thickness), but relatively high at the less nonprehensile hand zones, such as the palm. Glove fabrication techniques for achieving such an opacity gradient are described. (U.S.)

  4. MUSIC RADIO-JOURNALISM

    Directory of Open Access Journals (Sweden)

    Dubovtceva Ludmila I.

    2014-04-01

    Full Text Available The article is based on years of practical experience, the author highlights the main radio genres in which music correspondent, music reviewer, music commentator, and music leading and a disc jockey work. Theoretical principles of their creative activities are analyzed in common journalistic genres, such as interview, reportage, talk show, live broadcast, radiofilm, as well as specialized genres like concert on demand and music competition. Journalist’ speech is seen as a logical element, the incoming with music in art-structural relationships. However, it does not become the predominant sound layer and aims to harmonious correlation or local penetration into music opus. In addition, important links in music journalism are defined the auxiliary "offscreen" editor's job and keeping the original sound archive. The author cites a number of own work examples on the air.

  5. Radio-adaptive response

    International Nuclear Information System (INIS)

    Ikushima, T.

    1992-01-01

    Knowledge about cellular events in mammalian cells exposed to low doses of ionizing radiation is meager. Recent works showed that human lymphocytes become resistant to radiation-induced chromosomal damage after exposure to low doses of ionizing radiation. Experimental evidence for radio-adaptive response (RAR) in cultured mammalian cells was obtained. Exposure to very low doses of gamma-rays or tritium beta-rays make cells less susceptible to the induction of micronuclei and sister chromatid exchanges by subsequent higher doses. Many important characteristics of the novel response suggest that RAR is a stress response resulting in the enhanced repair of chromosomal DNA damage in cell under restricted conditions. Experiments are still in progress in order to elucidate the molecular basis for RAR processes. (author). 13 refs.; 2 figs., 1 tab

  6. Implementing Software Defined Radio

    CERN Document Server

    Grayver, Eugene

    2013-01-01

    Software Defined Radio makes wireless communications easier, more efficient, and more reliable. This book bridges the gap between academic research and practical implementation. When beginning a project, practicing engineers, technical managers, and graduate students can save countless hours by considering the concepts presented in these pages. The author covers the myriad options and trade-offs available when selecting an appropriate hardware architecture. As demonstrated here, the choice between hardware- and software-centric architecture can mean the difference between meeting an aggressive schedule and bogging down in endless design iterations. Because of the author’s experience overseeing dozens of failed and successful developments, he is able to present many real-life examples. Some of the key concepts covered are: Choosing the right architecture for the market – laboratory, military, or commercial Hardware platforms – FPGAs, GPPs, specialized and hybrid devices Standardization efforts to ens...

  7. Radio-adaptive response

    International Nuclear Information System (INIS)

    Ikushima, Takaji

    1991-01-01

    An adaptive response to radiation stress was found in cultured Chinese hamster V79 cells, as a suppressed induction of micronuclei (MNs) and sister chromatid exchanges (SCEs) in the cells conditioned by very low doses. The important characteristics of the novel chromosomal response, called radio-adaptive response (RAR), that have newly emerged in this study are: 1) Low doses of beta-rays from tritiated water (HTO) as well as tritiated thymidine can cause the RAR. 2) Thermal neutrons, a high LET radiation, can not act as tritium beta-rays or gamma-rays. 3) The RAR expression is suppressed by an inhibition of protein synthesis. 4) Several proteins are newly synthesized concurrently with the RAR expression after adapting doses, viewed by two-dimensional electrophoresis of cellular proteins. These results suggest that the RAR is an adaptive chromosomal DNA repair induced by very low doses of low LET radiations under restricted conditions, accompanying the inducible specific gene expression. (author)

  8. A turbulent radio jet

    International Nuclear Information System (INIS)

    Kahn, F.D.

    1983-01-01

    A relativistic plasma flow can explain many of the observations on the one-sided jets, which are associated with radio sources that show superluminal motions in their cores. The pressure from the ambient medium will communicate across the jet in a relatively short distance, typically 30 kpc. The friction between the jet and the external medium then makes the flow go turbulent. As a result the jet dissipates energy and will be brought to rest within a few hundred kpc, if it does not strike an obstacle before. The mean flow in the jet is strongly sheared and stretches the lines of force of any magnetic field frozen into the plasma. The dominant field direction, as seen from the rest frame of the plasma, is therefore parallel to the length of the jet. Polarization measurements have shown that this is in fact the case. (author)

  9. AGONIZAN RADIOS MINERAS

    Directory of Open Access Journals (Sweden)

    Raquel Salinas

    2015-01-01

    Full Text Available Se ofrece un amplio análisis sobre la industria electoral, recordando que un candidato a presidente es "un producto para la venta". Se Desmenuzan las estrategias utilizadas en el plebiscito chileno,las elecciones norteamericanas con el NO a BUSH. El Mercadeo Social es una nueva metodología utilizada en proyectos de desarrollo a nivel de campo por ello se hace un esclarecimiento y clarifica el vínculo con la comunicación. Se agrega temas como: Los modelos de recepción de mensajes cuyos marcos conceptuales y metodologías aún no se han adaptado al potencial de esta línea de trabajo.Se analiza la agonía de las radios mineras en Bolivia en la que 42 años de historia y heroísmo se desmoronan.

  10. Radio-isotopic tracers

    International Nuclear Information System (INIS)

    Wolfangel, R.G.

    1976-01-01

    The invention concerns the dispersions that may be used for preparing radio-isotopic tracers, technetium labelled dispersions, processes for preparing these dispersions and their use as tracers. Technetium 99m sulphur colloids are utilized as scintillation tracers to give a picture of the reticulo-endothelial system, particularly the liver and spleen. A dispersion is provided which only requires the addition of a radioactive nuclide to form a radioactively labelled dispersion that can be injected as a tracer. It is formed of a colloid of tin sulphur dispersed in an aqueous buffer solution. Such a reagent has the advantage of being safe and reliable and is easier to use. The colloid can be prepared more quickly since additions of several different reagents are avoided. There is no need to heat up and no sulphuretted hydrogen, which is a toxic gas, is used [fr

  11. Radio frequency picosecond phototube

    International Nuclear Information System (INIS)

    Margaryan, A.; Carlini, R.; Ent, R.; Grigoryan, N.; Gyunashyan, K.; Hashimoto, O.; Hovater, K.; Ispiryan, M.; Knyazyan, S.; Kross, B.; Majewski, S.; Marikyan, G.; Mkrtchyan, M.; Parlakyan, L.; Popov, V.; Tang, L.; Vardanyan, H.; Yan, C.; Zhamkochyan, S.; Zorn, C.

    2006-01-01

    We propose a photon detector for recording low-level and ultra-fast optical signals, based on radio frequency (RF) analysis of low-energy photoelectrons (PEs). By using currently developed 500 MHz RF deflector, it is possible to scan circularly and detect single PEs, amplified in multi-channel plates (MCPs). The operation of the tube is investigated by means of thermionic electron source. It is demonstrated that the signals generated in the MCP can be processed event by event; by using available nanosecond electronics and that time resolution better than 20 ps can be achieved. Timing characteristics of the Cherenkov detector with RF phototube in a 'head-on' geometry is investigated by means of Monte Carlo simulation

  12. Radio frequency picosecond phototube

    Energy Technology Data Exchange (ETDEWEB)

    Margaryan, A. [Yerevan Physics Institute, 2 Alikhanian Brothers Street, Yerevan 375036 (Armenia)]. E-mail: mat@mail.yerphi.am; Carlini, R. [Thomas Jefferson National Accelerator Facility, Newport News VA 23606 (United States); Ent, R. [Thomas Jefferson National Accelerator Facility, Newport News VA 23606 (United States); Grigoryan, N. [Yerevan Physics Institute, 2 Alikhanian Brothers Street, Yerevan 375036 (Armenia); Gyunashyan, K. [Yerevan State University of Architecture and Construction, Yerevan (Armenia); Hashimoto, O. [Tohoku University, Sendai 98-77 (Japan); Hovater, K. [Thomas Jefferson National Accelerator Facility, Newport News VA 23606 (United States); Ispiryan, M. [University of Houston, 4800 Calhoun Rd, Houston TX 77204 (United States); Knyazyan, S. [Yerevan Physics Institute, 2 Alikhanian Brothers Street, Yerevan 375036 (Armenia); Kross, B. [Thomas Jefferson National Accelerator Facility, Newport News VA 23606 (United States); Majewski, S. [Thomas Jefferson National Accelerator Facility, Newport News VA 23606 (United States); Marikyan, G. [Yerevan Physics Institute, 2 Alikhanian Brothers Street, Yerevan 375036 (Armenia); Mkrtchyan, M. [Yerevan Physics Institute, 2 Alikhanian Brothers Street, Yerevan 375036 (Armenia); Parlakyan, L. [Yerevan Physics Institute, 2 Alikhanian Brothers Street, Yerevan 375036 (Armenia); Popov, V. [Thomas Jefferson National Accelerator Facility, Newport News VA 23606 (United States); Tang, L. [Thomas Jefferson National Accelerator Facility, Newport News VA 23606 (United States); Vardanyan, H. [Yerevan Physics Institute, 2 Alikhanian Brothers Street, Yerevan 375036 (Armenia); Yan, C. [Thomas Jefferson National Accelerator Facility, Newport News VA 23606 (United States); Zhamkochyan, S. [Yerevan Physics Institute, 2 Alikhanian Brothers Street, Yerevan 375036 (Armenia); Zorn, C. [Thomas Jefferson National Accelerator Facility, Newport News VA 23606 (United States)

    2006-10-15

    We propose a photon detector for recording low-level and ultra-fast optical signals, based on radio frequency (RF) analysis of low-energy photoelectrons (PEs). By using currently developed 500 MHz RF deflector, it is possible to scan circularly and detect single PEs, amplified in multi-channel plates (MCPs). The operation of the tube is investigated by means of thermionic electron source. It is demonstrated that the signals generated in the MCP can be processed event by event; by using available nanosecond electronics and that time resolution better than 20 ps can be achieved. Timing characteristics of the Cherenkov detector with RF phototube in a 'head-on' geometry is investigated by means of Monte Carlo simulation.

  13. Radio propagation measurement and channel modelling

    CERN Document Server

    Salous, Sana

    2013-01-01

    While there are numerous books describing modern wireless communication systems that contain overviews of radio propagation and radio channel modelling, there are none that contain detailed information on the design, implementation and calibration of radio channel measurement equipment, the planning of experiments and the in depth analysis of measured data. The book would begin with an explanation of the fundamentals of radio wave propagation and progress through a series of topics, including the measurement of radio channel characteristics, radio channel sounders, measurement strategies

  14. A Radio Astronomy Science Education Partnership - GAVRT and Radio JOVE

    Science.gov (United States)

    Higgins, C. A.; Thieman, J. R.; Bunnell, K.; Soholt, G.

    2009-12-01

    The planet Jupiter provides an excellent subject to educate, engage, and inspire students and teachers to learn science. The Goldstone Apple-Valley Radio Telescope (GAVRT) program (http://www.lewiscenter.org/gavrt) and The Radio JOVE project (http://radiojove.gsfc.nasa.gov) each have a long history of allowing students and teachers to interact with scientists and real radio telescopes. The upcoming Juno mission to Jupiter (2011 launch) allows both GAVRT and Radio JOVE to combine efforts and engage with the NASA Juno mission, thus increasing the excitement and learning potential for teachers, students, and the general public. Teachers can attend workshops for training to operate a 34-meter radio telescope and/or build their own simple radio telescope, both of which can be used directly in the classroom. We will overview some classroom activities and highlight some teacher-student experiences. In addition, we will update our efforts on greater Web-based control of the radio telescopes, as well as highlight our upcoming workshops to allow better access for teachers in different parts of the Country.

  15. South African Radio League Introduction to Amateur Radio: A study guide for the Radio Amateur Examination

    CSIR Research Space (South Africa)

    Burger, Chris

    2016-01-01

    Full Text Available ) .............................................................................. 15 1.12 The Radio Amateurs’ Examination .......................................................................... 15 1.13 Restrictions on the Use of an Amateur Radio Station .............................................. 16 Chapter 2: Operating... ............................................................................................. 116 14.1 Theory of Operation ............................................................................................... 116 14.2 Turns Ratio...

  16. Potential impacts of shipping noise on Indo-Pacific humpback dolphins and implications for regulation and mitigation: a review.

    Science.gov (United States)

    Li, Songhai; Liu, Mingming; Dong, Lijun; Dong, Jianchen; Wang, Ding

    2018-01-09

    Shipping noise is a widespread and relatively loud sound source among human-induced underwater sounds. The impacts of shipping noise are of special concern for Indo-Pacific humpback dolphins (Sousa chinensis), as they inhabit shallow and nearshore habitats and are highly dependent on sound for survival. This study synthesizes our current understanding of the potential impacts of shipping noise on Indo-Pacific humpback dolphins combined with knowledge on sound production and hearing of these animals and the impacts of noise on other whales and dolphins. For further protection and management of Indo-Pacific humpback dolphins and their habitats, shipping noise should be regulated and mitigated to modify sound from ships, to reduce overall noise levels, and to set more marine protected areas (MPAs) covering most Indo-Pacific humpback dolphin habitats with seasonal and geographical restrictions to avoid ensonification of shipping noise. The emphasis for future research should be on obtaining more baseline information about the population distribution, sound production, hearing capabilities at the population level, behavior, and stress hormones of the humpback dolphins under different noise conditions or under different noise-producing activities, and/or in high-noise areas compared with relatively quiet areas, and the noise characteristics of ships of different types, sizes, and speeds. This article is protected by copyright. All rights reserved.

  17. Mediality is Noise

    DEFF Research Database (Denmark)

    Prior, Andrew

    This PhD is concerned with the use of noise as a material within media arts practice, especially in ‘post-digital’ contexts such as glitch electronica, glitch art and uses of old media. It examines the relationship between informational culture and noise, exploring the ways in which the structuring...

  18. Post commissioning noise study

    International Nuclear Information System (INIS)

    Heraud, P.

    2008-01-01

    This presentation described a wind farm post-commissioning study conducted at a wind farm owned by Helimax Energy Inc. The farm was located in a partly-forested, partly cultivated region in Quebec that featured gently rolling hills. Over 600 dwellings were located within 2 km of the wind farm, and 44 dwellings were within the wind farm's boundaries. The noise impact assessments were conducted at various points near the wind farm. The wind farm was designed using an International Standards Organization (ISO) noise propagation model and a 40 dBA to provide adequate setbacks. The study was conducted using 10 days of continuous measurements at selected points of a wind farm. Points of reception included points from 650 m to 800 m. Noise over 2 km was not thought to be contributed by the wind turbine. The nearest dwelling was 512 m from one of the farm's wind turbines. The study also considered ground factor, temperature, relative humidity, and the height of the receptors. Quebec noise level limits are 40 dBA at night, and 45 dBA during the day. Noise level limits are independent of wind speed. Measured noise contributions over 40 dBA were not observed during the measurement program. The wind turbines were only audible for 1 night out of the 30 night study period. It was concluded that the ISO noise propagation model is a reliable tool for conducting noise impact assessments. tabs., figs

  19. Noise, buildings and people

    Energy Technology Data Exchange (ETDEWEB)

    Croome, D J

    1977-01-01

    This book covers the physics of acoustics necessary to understand the analytical aspects of acoustical design and noise control in buildings. The major part is devoted to the problems of noise and man, and other chapters cover features of noise control in and around buildings. In an introduction, building environmental engineering is dealth with in general terms of architecture, creativity, systms design, etc. Aspects of the acoustical environment, noise sources in buildings, control of airborne and structure-borne noise and acoustical design techniques are covered in Part II. Items include: comfort, physiological response to noise and vibrations, noise criteria, human performance, speech communication, landscaped offices, sound generation by air-conditioning and heating equipment, building structure and noise attenuation, acoustical design. Part III gives some fundamentals of acoustics; mechanical vibration, wave motion, propagation of sound, structure-borne sound, behavior of sound in rooms, transmission of sound through structure. References include lists of British standards and booklets on health and safety at work.

  20. Low frequency noise study.

    Science.gov (United States)

    2007-04-01

    This report documents a study to investigate human response to the low-frequency : content of aviation noise, or low-frequency noise (LFN). The study comprised field : measurements and laboratory studies. The major findings were: : 1. Start-of-takeof...

  1. Noise Pollution, Teachers' Edition.

    Science.gov (United States)

    O'Donnell, Patrick A.; Lavaroni, Charles W.

    One of three in a series about pollution, this teacher's guide for a unit on noise pollution is designed for use in junior high school grades. It offers suggestions for extending the information and activities contained in the textual material for students. Chapter 1 discusses the problem of noise pollution and involves students in processes of…

  2. Noise from wind turbines

    International Nuclear Information System (INIS)

    Andersen, B.; Larsen, P.

    1993-01-01

    Denmark has 3200 wind turbines with an installed maximum capacity of 418MW. The most important Danish research projects into wind turbine noise and the main results are listed. These date from 1983. Two comprehensive studies are currently in progress. The first is an analytical and empirical investigation of aerodynamic noise from wind turbine rotors and has so far dealt mainly with tip noise. The measurement method, using a hard board mounted microphone on the ground near the turbine, is described. Four different tip designs have been tested. Some examples of reference sound power level spectra for three of the designs are presented. During the past two years a computerbased data acquisition system has been used for real-time determination of sound power levels. The second study, which has just commenced, is on annoyance from wind turbine noise. It will include noise measurements, masking calculations and a social survey on the perceived nuisance. (UK)

  3. Noise from wind turbines

    International Nuclear Information System (INIS)

    Andersen, B.; Jakobsen, J.

    1992-11-01

    Based on a previous project concerning the calculation of the amount of noise emanating from wind turbine arrays, this one examines the subject further by investigating whether there could be significant differences in the amount of noise made by individual wind turbines in an array, and whether the noise is transmitted in varying directions - so that when it is carried in the same direction as the wind blows it would appear to be louder. The aim was also to determine whether the previously used method of calculation lacked precision. It was found that differences in noise niveaux related to individual wind turbines were insignificant and that noise was not so loud when it was not borne in the direction of the wind. It was necessary to change the method of calculation as reckoning should include the influence of the terrain, wind velocity and distance. The measuring and calculation methods are exemplified and the resulting measurements are presented in detail. (AB)

  4. Reactor noise monitoring device

    International Nuclear Information System (INIS)

    Yamanaka, Hiroto.

    1990-01-01

    The present invention concerns a reactor noise monitoring device by detecting abnormal sounds in background noises. Vibration sounds detected by accelerometers are applied to a loose parts detector. The detector generates high alarm if there are sudden impact sounds in the background noises and applies output signals to an accumulation device. If there is slight impact sounds in the vicinity of any of the accelerometers, the accumulation device accumulates the abnormal sounds assumed to be generated from an identical site while synchronizing the waveforms for all of the channels. Then, the device outputs signals in which the background noises are cancelled, as detection signals. Therefore, S/N ratio can be improved and the abnormal sounds contained in the background noises can be detected, to thereby improve the accuracy for estimating the position where the abnormal sounds are generated. (I.S.)

  5. Noise Enhanced Stability

    International Nuclear Information System (INIS)

    Spagnolo, B.; Agudov, N.V.; Dubkov, A.A.

    2004-01-01

    The noise can stabilize a fluctuating or a periodically driven metastable state in such a way that the system remains in this state for a longer time than in the absence of white noise. This is the noise enhanced stability phenomenon, observed experimentally and numerically in different physical systems. After shortly reviewing all the physical systems where the phenomenon was observed, the theoretical approaches used to explain the effect are presented. Specifically the conditions to observe the effect in systems: (a) with periodical driving force, and (b) with random dichotomous driving force, are discussed. In case (b) we review the analytical results concerning the mean first passage time and the nonlinear relaxation time as a function of the white noise intensity, the parameters of the potential barrier, and of the dichotomous noise. (author)

  6. Signal Detection for QPSK Based Cognitive Radio Systems using Support Vector Machines

    Directory of Open Access Journals (Sweden)

    M. T. Mushtaq

    2015-04-01

    Full Text Available Cognitive radio based network enables opportunistic dynamic spectrum access by sensing, adopting and utilizing the unused portion of licensed spectrum bands. Cognitive radio is intelligent enough to adapt the communication parameters of the unused licensed spectrum. Spectrum sensing is one of the most important tasks of the cognitive radio cycle. In this paper, the auto-correlation function kernel based Support Vector Machine (SVM classifier along with Welch's Periodogram detector is successfully implemented for the detection of four QPSK (Quadrature Phase Shift Keying based signals propagating through an AWGN (Additive White Gaussian Noise channel. It is shown that the combination of statistical signal processing and machine learning concepts improve the spectrum sensing process and spectrum sensing is possible even at low Signal to Noise Ratio (SNR values up to -50 dB.

  7. Purification of human induced pluripotent stem cell-derived neural precursors using magnetic activated cell sorting.

    Science.gov (United States)

    Rodrigues, Gonçalo M C; Fernandes, Tiago G; Rodrigues, Carlos A V; Cabral, Joaquim M S; Diogo, Maria Margarida

    2015-01-01

    Neural precursor (NP) cells derived from human induced pluripotent stem cells (hiPSCs), and their neuronal progeny, will play an important role in disease modeling, drug screening tests, central nervous system development studies, and may even become valuable for regenerative medicine treatments. Nonetheless, it is challenging to obtain homogeneous and synchronously differentiated NP populations from hiPSCs, and after neural commitment many pluripotent stem cells remain in the differentiated cultures. Here, we describe an efficient and simple protocol to differentiate hiPSC-derived NPs in 12 days, and we include a final purification stage where Tra-1-60+ pluripotent stem cells (PSCs) are removed using magnetic activated cell sorting (MACS), leaving the NP population nearly free of PSCs.

  8. Cell adhesion monitoring of human induced pluripotent stem cell based on intrinsic molecular charges

    Science.gov (United States)

    Sugimoto, Haruyo; Sakata, Toshiya

    2014-01-01

    We have shown a simple way for real-time, quantitative, non-invasive, and non-label monitoring of human induced pluripotent stem (iPS) cell adhesion by use of a biologically coupled-gate field effect transistor (bio-FET), which is based on detection of molecular charges at cell membrane. The electrical behavior revealed quantitatively the electrical contacts of integrin-receptor at the cell membrane with RGDS peptide immobilized at the gate sensing surface, because that binding site was based on cationic α chain of integrin. The platform based on the bio-FET would provide substantial information to evaluate cell/material bio-interface and elucidate biding mechanism of adhesion molecules, which could not be interpreted by microscopic observation.

  9. Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins

    Directory of Open Access Journals (Sweden)

    Hayato Fukusumi

    2016-01-01

    Full Text Available Human neural progenitor cells (hNPCs have previously been generated from limited numbers of human induced pluripotent stem cell (hiPSC clones. Here, 21 hiPSC clones derived from human dermal fibroblasts, cord blood cells, and peripheral blood mononuclear cells were differentiated using two neural induction methods, an embryoid body (EB formation-based method and an EB formation method using dual SMAD inhibitors (dSMADi. Our results showed that expandable hNPCs could be generated from hiPSC clones with diverse somatic tissue origins. The established hNPCs exhibited a mid/hindbrain-type neural identity and uniform expression of neural progenitor genes.

  10. An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Julia TCW

    2017-08-01

    Full Text Available Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from human induced pluripotent stem cells (hiPSCs, via a neural progenitor cell (NPC intermediate. We evaluated this protocol across 42 NPC lines (derived from 30 individuals. Transcriptomic analysis demonstrated that hiPSC-astrocytes from four individuals are highly similar to primary human fetal astrocytes and characteristic of a non-reactive state. hiPSC-astrocytes respond to inflammatory stimulants, display phagocytic capacity, and enhance microglial phagocytosis. hiPSC-astrocytes also possess spontaneous calcium transient activity. Our protocol is a reproducible, straightforward (single medium, and rapid (<30 days method to generate populations of hiPSC-astrocytes that can be used for neuron-astrocyte and microglia-astrocyte co-cultures for the study of neuropsychiatric disorders.

  11. Development and Characterization of a Brain Endothelial Cell Phenotype using Human Induced Pluripotent Stem Cells

    DEFF Research Database (Denmark)

    Goldeman, Charlotte; Saaby, Lasse; Holst, Bjørn

    for experiments the following day. The model was monitored by measuring the trans-endothelial electrical resistance (TEER). RA had an inductive effect on the model, shown by an elevation in barrier tightness which correlated with the presence of tight junction proteins, shown by confocal microscopy images which...... be used to investigate drug transport in vitro, and screen candidates for permeation properties. One recent approach is to develop in vitro models of the BBB using human induced pluripotent stem cells (hIPSCs) as described by Stebbins et al. (2015).The aim of the present study was to investigate whether...... the published protocols were generically applicable and thus to develop and characterize in vitro models of the BBB using hIPSCs from different sources. Two stem cell lines, Bioni010-C and WTSli024-A, were seeded and maintained on Matrigel in mTesR1 media. Cells were then seeded as single cells at different...

  12. Human induced pluripotent stem cells: a review of the US patent landscape.

    Science.gov (United States)

    Georgieva, Bilyana P; Love, Jane M

    2010-07-01

    Human induced pluripotent stem (iPS) cells and human embryonic stem cells are cells that have the ability to differentiate into a variety of cell types. Embryonic stem cells are derived from human embryos; however, by contrast, human iPS cells can be obtained from somatic cells that have undergone a process of 'reprogramming' via genetic manipulation such that they develop pluripotency. Since iPS cells are not derived from human embryos, they are a less complicated source of human pluripotent cells and are considered valuable research tools and potentially useful in therapeutic applications in regenerative medicine. Worldwide, there are only three issued patents concerning iPS cells. Therefore, the patent landscape in this field is largely undefined. This article provides an overview of the issued patents as well as the pending published patent applications in the field.

  13. X rays from radio binaries

    International Nuclear Information System (INIS)

    Apparao, K.M.V.

    1977-01-01

    Reference is made to the radio binary systems CC Cas, AR Lac, β Per (Algol), β Lyr, b Per and Cyg X-1. It is stated that a thermal interpretation of the radiation from Algol requires a much larger x-ray flux than the observed value of 3.8 x 10 -11 erg/cm 2 /sec/keV in the 2 to 6 keV energy range. Observations of some non-thermal flares, together with the small size of the radio source in Algol, indicate that the radio emission is non-thermal in nature. The radio emission is interpreted as synchrotron radiation and it is suggested that the observed x-ray emission is due to inverse Compton scattering of the light of the primary star by the radio electrons. The x-ray emission from other radio binaries is also calculated using this model. The energy for the radio electrons can arise from annihilation of magnetic lines connecting the binary stars, twisted by the rotation of the stars. (U.K.)

  14. Roles of CDX2 and EOMES in human induced trophoblast progenitor cells

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Ying, E-mail: ying.chen@hc.msu.edu [Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503 (United States); Wang, Kai [Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503 (United States); Gong, Yun Guo; Khoo, Sok Kean [Genomic Microarray Core Facility, Van Andel Research Institute, Grand Rapids, MI 49503 (United States); Leach, Richard, E-mail: Richard.Leach@hc.msu.edu [Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503 (United States); Department of Obstetrics, Gynecology and Women’s Health, Spectrum Health Medical Group, Grand Rapids, MI 49503 (United States)

    2013-02-08

    Highlights: ► CDX2 and EOMES play critical roles in human induced trophoblast progenitors (iTP). ► iTP cells directly transformed from fibroblasts. ► Differentiation of iTP cells into extravillous trophoblasts and syncytiotrophoblasts. -- Abstract: Abnormal trophoblast lineage proliferation and differentiation in early pregnancy have been associated with the pathogenesis of placenta diseases of pregnancy. However, there is still a gap in understanding the molecular mechanisms of early placental development due to the limited primary trophoblast cultures and fidelity of immortalized trophoblast lines. Trophoblasts stem (TS) cells, an in vitro model of trophectoderm that can differentiate into syncytiotrophoblasts and extravillous trophoblasts, can be an attractive tool for early pregnancy research. TS cells are well established in mouse but not in humans due to insufficient knowledge of which trophoblast lineage-specific transcription factors are involved in human trophectoderm (TE) proliferation and differentiation. Here, we applied induced pluripotent stem cell technique to investigate the human trophoblast lineage-specific transcription factors. We established human induced trophoblast progenitor (iTP) cells by direct reprogramming the fibroblasts with a pool of mouse trophoblast lineage-specific transcription factors consisting of CDX2, EOMES, and ELF5. The human iTP cells exhibit epithelial morphology and can be maintained in vitro for more than 2 months. Gene expression profile of these cells was tightly clustered with human trophectoderm but not with human neuron progenitor cells, mesenchymal stem cells, or endoderm cells. These cells are capable of differentiating into cells with an invasive capacity, suggesting extravillous trophoblasts. They also form multi-nucleated cells which secrete human chorionic gonadotropin and estradiol, consistent with a syncytiotrophoblast phenotype. Our results provide the evidence that transcription factors CDX2 and

  15. Speech understanding in noise with integrated in-ear and muff-style hearing protection systems

    Directory of Open Access Journals (Sweden)

    Sharon M Abel

    2011-01-01

    Full Text Available Integrated hearing protection systems are designed to enhance free field and radio communications during military operations while protecting against the damaging effects of high-level noise exposure. A study was conducted to compare the effect of increasing the radio volume on the intelligibility of speech over the radios of two candidate systems, in-ear and muff-style, in 85-dBA speech babble noise presented free field. Twenty normal-hearing, English-fluent subjects, half male and half female, were tested in same gender pairs. Alternating as talker and listener, their task was to discriminate consonant-vowel-consonant syllables that contrasted either the initial or final consonant. Percent correct consonant discrimination increased with increases in the radio volume. At the highest volume, subjects achieved 79% with the in-ear device but only 69% with the muff-style device, averaged across the gender of listener/talker pairs and consonant position. Although there was no main effect of gender, female listener/talkers showed a 10% advantage for the final consonant and male listener/talkers showed a 1% advantage for the initial consonant. These results indicate that normal hearing users can achieve reasonably high radio communication scores with integrated in-ear hearing protection in moderately high-level noise that provides both energetic and informational masking. The adequacy of the range of available radio volumes for users with hearing loss has yet to be determined.

  16. 75 FR 10439 - Cognitive Radio Technologies and Software Defined Radios

    Science.gov (United States)

    2010-03-08

    ... petition could not through the exercise of due diligence have learned of the facts in question prior to... to a wide variety of radio services, including safety-of-life services--the Commission holds the...

  17. radio frequency based radio frequency based water level monitor

    African Journals Online (AJOL)

    eobe

    ABSTRACT. This paper elucidates a radio frequency (RF) based transmission and reception system used to remotely monitor and .... range the wireless can cover but in this prototype, it ... power supply to the system, the sensed water level is.

  18. Introduction to solar radio astronomy and radio physics

    International Nuclear Information System (INIS)

    Krueger, A.

    1979-01-01

    A systematic summary is presented of the work done during the last thirty years in the field of solar radio astronomy from the standpoint of general solar physics. Instrumental aspects, observations and theory are covered. A brief introduction is given to the matter consisting of the history of solar radio astronomy and some fundamentals of astronomy and solar physics are outlined. Some topics of the instrumental background of solar radio astronomy and the main results of observations are presented. The elements of a theoretical interpretation of solar radio observations are reported and a synthesis of both observation and theory contributing to a general picture of solar and solar-terrestrial physics is outlined. (C.F./Auth)

  19. Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales.

    Science.gov (United States)

    Huebsch, Nathaniel; Loskill, Peter; Mandegar, Mohammad A; Marks, Natalie C; Sheehan, Alice S; Ma, Zhen; Mathur, Anurag; Nguyen, Trieu N; Yoo, Jennie C; Judge, Luke M; Spencer, C Ian; Chukka, Anand C; Russell, Caitlin R; So, Po-Lin; Conklin, Bruce R; Healy, Kevin E

    2015-05-01

    Contractile motion is the simplest metric of cardiomyocyte health in vitro, but unbiased quantification is challenging. We describe a rapid automated method, requiring only standard video microscopy, to analyze the contractility of human-induced pluripotent stem cell-derived cardiomyocytes (iPS-CM). New algorithms for generating and filtering motion vectors combined with a newly developed isogenic iPSC line harboring genetically encoded calcium indicator, GCaMP6f, allow simultaneous user-independent measurement and analysis of the coupling between calcium flux and contractility. The relative performance of these algorithms, in terms of improving signal to noise, was tested. Applying these algorithms allowed analysis of contractility in iPS-CM cultured over multiple spatial scales from single cells to three-dimensional constructs. This open source software was validated with analysis of isoproterenol response in these cells, and can be applied in future studies comparing the drug responsiveness of iPS-CM cultured in different microenvironments in the context of tissue engineering.

  20. Ulysses radio and plasma wave observations in the jupiter environment.

    Science.gov (United States)

    Stone, R G; Pedersen, B M; Harvey, C C; Canu, P; Cornilleau-Wehrlin, N; Desch, M D; de Villedary, C; Fainberg, J; Farrell, W M; Goetz, K; Hess, R A; Hoang, S; Kaiser, M L; Kellogg, P J; Lecacheux, A; Lin, N; Macdowall, R J; Manning, R; Meetre, C A; Meyer-Vernet, N; Moncuquet, M; Osherovich, V; Reiner, M J; Tekle, A; Thiessen, J; Zarka, P

    1992-09-11

    The Unified Radio and Plasma Wave (URAP) experiment has produced new observations of the Jupiter environment, owing to the unique capabilities of the instrument and the traversal of high Jovian latitudes. Broad-band continuum radio emission from Jupiter and in situ plasma waves have proved valuable in delineating the magnetospheric boundaries. Simultaneous measurements of electric and magnetic wave fields have yielded new evidence of whistler-mode radiation within the magnetosphere. Observations of aurorallike hiss provided evidence of a Jovian cusp. The source direction and polarization capabilities of URAP have demonstrated that the outer region of the lo plasma torus supported at least five separate radio sources that reoccurred during successive rotations with a measurable corotation lag. Thermal noise measurements of the lo torus densities yielded values in the densest portion that are similar to models suggested on the basis of Voyager observations of 13 years ago. The URAP measurements also suggest complex beaming and polarization characteristics of Jovian radio components. In addition, a new class of kilometer-wavelength striated Jovian bursts has been observed.

  1. Introduction to international radio regulations

    Energy Technology Data Exchange (ETDEWEB)

    Struzak, R

    2003-12-15

    These notes introduce the ITU Radio Regulations and related UN and WTO agreements that specify how terrestrial and satellite radio should be used in all countries over the planet. Access to the existing information infrastructure, and to that of the future Information Society, depends critically on these regulations. The paper also discusses few problems related to the use of the radio frequencies and satellite orbits. The notes are extracted from a book under preparation, in which these issues are discussed in more detail. (author)

  2. Introduction to international radio regulations

    International Nuclear Information System (INIS)

    Struzak, R.

    2003-01-01

    These notes introduce the ITU Radio Regulations and related UN and WTO agreements that specify how terrestrial and satellite radio should be used in all countries over the planet. Access to the existing information infrastructure, and to that of the future Information Society, depends critically on these regulations. The paper also discusses few problems related to the use of the radio frequencies and satellite orbits. The notes are extracted from a book under preparation, in which these issues are discussed in more detail. (author)

  3. Magnetogasdynamics of double radio sources

    International Nuclear Information System (INIS)

    Nepveu, M.

    1979-01-01

    The magnetogasdynamical behaviour of plasmoids moving through an ambient gas is investigated numerically with a two-dimensional code, based on the SHASTA scheme. The astrophysical importance of this study lies in the observed extended extragalactic radio sources. It is assumed that plasma clouds with cylinder symmetry are ejected from the nucleus of a galaxy. Their large-scale evolution in the intergalactic medium (IGM) is followed. The gas dynamics of an ejected cloud, the magnetogasdynamics of ejected clouds, the Christiansen-Pacholczyk-Scott picture for radio galaxies and the shear layers in double radio sources are studied. (Auth.)

  4. Shoestring Budget Radio Astronomy (Abstract)

    Science.gov (United States)

    Hoot, J. E.

    2017-12-01

    (Abstract only) The commercial exploitation of microwave frequencies for cellular, WiFi, Bluetooth, HDTV, and satellite digital media transmission has brought down the cost of the components required to build an effective radio telescope to the point where, for the cost of a good eyepiece, you can construct and operate a radio telescope. This paper sets forth a family of designs for 1421 MHz telescopes. It also proposes a method by which operators of such instruments can aggregate and archive data via the Internet. With 90 or so instruments it will be possible to survey the entire radio sky for transients with a 24 hour cadence.

  5. Effects of background noise on total noise annoyance

    Science.gov (United States)

    Willshire, K. F.

    1987-01-01

    Two experiments were conducted to assess the effects of combined community noise sources on annoyance. The first experiment baseline relationships between annoyance and noise level for three community noise sources (jet aircraft flyovers, traffic and air conditioners) presented individually. Forty eight subjects evaluated the annoyance of each noise source presented at four different noise levels. Results indicated the slope of the linear relationship between annoyance and noise level for the traffic noise was significantly different from that of aircraft and of air conditioner noise, which had equal slopes. The second experiment investigated annoyance response to combined noise sources, with aircraft noise defined as the major noise source and traffic and air conditioner noise as background noise sources. Effects on annoyance of noise level differences between aircraft and background noise for three total noise levels and for both background noise sources were determined. A total of 216 subjects were required to make either total or source specific annoyance judgements, or a combination of the two, for a wide range of combined noise conditions.

  6. Noise and Hearing Loss Prevention

    Science.gov (United States)

    ... message, please visit this page: About CDC.gov . NOISE AND HEARING LOSS PREVENTION Language: English (US) Español ( ... when hazardous noise levels cannot be adequately reduced. Noise and Hearing Loss on the NIOSH Science Blog ...

  7. The excess radio background and fast radio transients

    International Nuclear Information System (INIS)

    Kehayias, John; Kephart, Thomas W.; Weiler, Thomas J.

    2015-01-01

    In the last few years ARCADE 2, combined with older experiments, has detected an additional radio background, measured as a temperature and ranging in frequency from 22 MHz to 10 GHz, not accounted for by known radio sources and the cosmic microwave background. One type of source which has not been considered in the radio background is that of fast transients (those with event times much less than the observing time). We present a simple estimate, and a more detailed calculation, for the contribution of radio transients to the diffuse background. As a timely example, we estimate the contribution from the recently-discovered fast radio bursts (FRBs). Although their contribution is likely 6 or 7 orders of magnitude too small (though there are large uncertainties in FRB parameters) to account for the ARCADE 2 excess, our development is general and so can be applied to any fast transient sources, discovered or yet to be discovered. We estimate parameter values necessary for transient sources to noticeably contribute to the radio background

  8. Radio frequency integrated circuit design for cognitive radio systems

    CERN Document Server

    Fahim, Amr

    2015-01-01

    This book fills a disconnect in the literature between Cognitive Radio systems and a detailed account of the circuit implementation and architectures required to implement such systems.  Throughout the book, requirements and constraints imposed by cognitive radio systems are emphasized when discussing the circuit implementation details.  In addition, this book details several novel concepts that advance state-of-the-art cognitive radio systems.  This is a valuable reference for anybody with background in analog and radio frequency (RF) integrated circuit design, needing to learn more about integrated circuits requirements and implementation for cognitive radio systems. ·         Describes in detail cognitive radio systems, as well as the circuit implementation and architectures required to implement them; ·         Serves as an excellent reference to state-of-the-art wideband transceiver design; ·         Emphasizes practical requirements and constraints imposed by cognitive radi...

  9. A radio and optical study of Molonglo radio sources

    Science.gov (United States)

    Ishwara-Chandra, C. H.; Saikia, D. J.; McCarthy, P. J.; van Breugel, W. J. M.

    2001-05-01

    We present multi-wavelength radio observations with the Very Large Array, and narrow- and broad-band optical observations with the 2.5-m telescope at the Las Campanas Observatory, of a well-defined sample of high-luminosity Fanaroff-Riley class II radio galaxies and quasars, selected from the Molonglo Reference Catalogue 1-Jy sample. These observations were carried out as part of a programme to investigate the effects of orientation and environment on some of the observed properties of these sources. We examine the dependence of the Liu-Pooley relationship, which shows that radio lobes with flatter radio spectra are less depolarized, on size, identification and redshift, and show that it is significantly stronger for smaller sources, with the strength of the relationship being similar for both radio galaxies and quasars. In addition to Doppler effects, there appear to be intrinsic differences between the lobes on opposite sides. We discuss the asymmetry in brightness and location of the hotspots, and present estimates of the ages and velocities from matched-resolution observations in the L and C bands. Narrow- and broad-band optical images of some of these sources were made to study their environments and correlate with the symmetry parameters. An extended emission-line region is seen in a quasar, and in four of the objects possible companion galaxies are seen close to the radio axis.

  10. Radio/FADS/IMU integrated navigation for Mars entry

    Science.gov (United States)

    Jiang, Xiuqiang; Li, Shuang; Huang, Xiangyu

    2018-03-01

    Supposing future orbiting and landing collaborative exploration mission as the potential project background, this paper addresses the issue of Mars entry integrated navigation using radio beacon, flush air data sensing system (FADS), and inertial measurement unit (IMU). The range and Doppler information sensed from an orbiting radio beacon, the dynamic pressure and heating data sensed from flush air data sensing system, and acceleration and attitude angular rate outputs from an inertial measurement unit are integrated in an unscented Kalman filter to perform state estimation and suppress the system and measurement noise. Computer simulations show that the proposed integrated navigation scheme can enhance the navigation accuracy, which enables precise entry guidance for the given Mars orbiting and landing collaborative exploration mission.

  11. Performance Enhancement of Optical CDMA by Differential-Phase Method for Radio-over-Fiber Transmissions

    Directory of Open Access Journals (Sweden)

    Hsu-Chih Cheng

    2013-01-01

    Full Text Available The study proposes the differential-phase optical code-division multiple-access (OCDMA network for radio-over-fiber (RoF transmissions, and the characteristics are numerically analyzed. The network coder/decoders (codecs are structured on the basis of arrayed-waveguide-grating (AWG routers with complementary Walsh-Hadamard (CWH signature codes. In the proposed system, the network requires only two AWG routers to accomplish spectral encoding of radio base station (RBS and decoding of control station for the complementary keying, thus resulting in a simpler and low cost system. Performance analyses are evaluated with the dominant noise of phase-induced intensity noise (PIIN in spectral code OCDMA network. By the proposed AWG-based OCDMA with the differential-phase scheme, it is possible to establish interference-free and low crosstalk beat noise RoF systems.

  12. Solar radio continuum storms and a breathing magnetic field model. Final report

    International Nuclear Information System (INIS)

    1975-01-01

    Radio noise continuum emissions observed in metric and decametric wave frequencies are, in general, associated with actively varying sunspot groups accompanied by the S-component of microwave radio emissions. These continuum emission sources, often called type I storm sources, are often associated with type III burst storm activity from metric to hectometric wave frequencies. This storm activity is, therefore, closely connected with the development of these continuum emission sources. It is shown that the S-component emission in microwave frequencies generally precedes, by several days, the emission of these noise continuum storms of lower frequencies. In order for these storms to develop, the growth of sunspot groups into complex types is very important in addition to the increase of the average magnetic field intensity and area of these groups. After giving a review on the theory of these noise continuum storm emissions, a model is briefly considered to explain the relation of the emissions to the storms

  13. Handbook Of Noise And Vibration

    International Nuclear Information System (INIS)

    1995-12-01

    This book is about noise and vibration. The first chapter has explanations of noise such as basic of sound, influence of noise, assessment of noise, measurement of prevention of noise and technology, case of noise measurement and soundproof. The second chapter describes vibration with outline, theory of vibration, interpretation of vibration, measurement for reduction of vibration, case of design of protection against vibration. It deals with related regulation and method of measurement.

  14. Radio-adaptive response

    International Nuclear Information System (INIS)

    Ikushima, T.

    1992-01-01

    An adaptive response to radiation stress was found as a suppressed induction of chromosomal damage including micronuclei and sister chromatid exchanges in cultured Chinese hamster V79 cells pre-exposed to very low doses of ionizing radiations. The mechanism underlying this novel chromosomal response, called 'radio-adaptive response (RAR)' has been studied progressively. The following results were obtained in recent experiments. 1. Low doses of β-rays from tritiated water (HTO) as well as tritium-thymidine can cause RAR. 2. Thermal neutrons, a high LET radiation, can not act as tritium β-rays or γ-rays. 3. The RAR expression is suppressed not only by the treatment with an inhibitor of protein synthesis but also by RNA synthesis inhibition. 4. Several proteins are newly synthesized concurrently with the RAR expression after the adapting doses, viewed by two-dimensional electrophoresis of cellular proteins. These results suggests that the RAR might be a cellular stress response to a signal produced preferentially by very low doses of low LET radiation under restricted conditions, accompany the inducible specific gene expression. (author)

  15. Introductory guide to noise

    CSIR Research Space (South Africa)

    Ferreira, T.M

    1973-01-01

    Full Text Available or (by remaining at the 'alarm' level) prevents us from sleeping or resting. Some noise comes into buildings from outside, such as when a passing jet plane drowns a telephone conversation or when traffic noise prevents one from hearing an interesting... on aircraft that make too much noise. Motor cars, buses, buzz-bikes and vacuum deaners can be effectively quietened but until now the public has not been prepared to pay the price of legislation. Also, many young sports-car enthusiasts still think...

  16. Controlled Noise Seismology

    KAUST Repository

    Hanafy, Sherif M.

    2015-08-19

    We use controlled noise seismology (CNS) to generate surface waves, where we continuously record seismic data while generating artificial noise along the profile line. To generate the CNS data we drove a vehicle around the geophone line and continuously recorded the generated noise. The recorded data set is then correlated over different time windows and the correlograms are stacked together to generate the surface waves. The virtual shot gathers reveal surface waves with moveout velocities that closely approximate those from active source shot gathers.

  17. Hypermedicalization in White Noise.

    Science.gov (United States)

    Benson, Josef

    2015-09-01

    The Nazis hijacked Germany's medical establishment and appropriated medical language to hegemonize their ideology. In White Noise, shifting medical information stifles the public into docility. In Nazi Germany the primacy of language and medical authority magnified the importance of academic doctors. The muddling of identities caused complex insecurities and the need for psychological doubles. In White Noise, Professor Gladney is driven by professional insecurities to enact a double in Murray. Through the manipulation of language and medical overreach the U.S., exemplified in the novel White Noise, has become a hypermedicalized society where the spirit of the Hippocratic Oath has eroded.

  18. Controlled Noise Seismology

    KAUST Repository

    Hanafy, Sherif M.; AlTheyab, Abdullah; Schuster, Gerard T.

    2015-01-01

    We use controlled noise seismology (CNS) to generate surface waves, where we continuously record seismic data while generating artificial noise along the profile line. To generate the CNS data we drove a vehicle around the geophone line and continuously recorded the generated noise. The recorded data set is then correlated over different time windows and the correlograms are stacked together to generate the surface waves. The virtual shot gathers reveal surface waves with moveout velocities that closely approximate those from active source shot gathers.

  19. Beamsteerable GNSS Radio Occultation ASIC

    Data.gov (United States)

    National Aeronautics and Space Administration — We will develop an integrated RF ASIC to enable high quality radio occultation (RO) weather observations using the Global Navigations System Satellite (GNSS)...

  20. Sea Turtle Radio Telemetry Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Radio transmitters attached to sea turtles captured in various fishing gear enabled us to track and measure surfacing time of each turtle. Determining location of...

  1. Zero-Power Radio Device.

    Energy Technology Data Exchange (ETDEWEB)

    Brocato, Robert W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2018-02-01

    This report describes an unpowered radio receiver capable of detecting and responding to weak signals transmit ted from comparatively long distances . This radio receiver offers key advantages over a short range zero - power radio receiver previously described in SAND2004 - 4610, A Zero - Power Radio Receiver . The device described here can be fabricated as an integrated circuit for use in portable wireless devices, as a wake - up circuit, or a s a stand - alone receiver operating in conjunction with identification decoders or other electroni cs. It builds on key sub - components developed at Sandia National Laboratories over many years. It uses surface acoustic wave (SAW) filter technology. It uses custom component design to enable the efficient use of small aperture antennas. This device uses a key component, the pyroelectric demodulator , covered by Sandia owned U.S. Patent 7397301, Pyroelectric Demodulating Detector [1] . This device is also described in Sandia owned U.S. Patent 97266446, Zero Power Receiver [2].

  2. EGRET Unidentified Source Radio Observations and Performance of Receiver Gain Calibration

    International Nuclear Information System (INIS)

    Niinuma, Kotaro; Asuma, Kuniyuki; Kuniyoshi, Masaya; Matsumura, Nobuo; Takefuji, Kazuhiro; Kida, Sumiko; Takeuchi, Akihiko; Ichikawa, Hajime; Sawano, Akihiro; Yoshimura, Naoya; Suzuki, Shigehiro; Nakamura, Ryosuke; Nakayama, Yu; Daishido, Tsuneaki

    2006-01-01

    Last year, we have developed the receiver gain calibration system by using Johnson-Nyquist noise, for accuracy flux measurement, because we have been starting radio identification program of transient radio sources, blazars and radio counterpart of The Energetic Gamma Ray Experiment Telescope (EGRET) unidentified γ-ray sources in Waseda Nasu Pulsar Observatory. It is shown that there are a few low correlation data between receiver gain and ambient temperature around receiver for anything troubles of receiver, because we can detect gain and ambient temperature through a day by developed system. Estimated fluctuations of daily data of steady sources decrease by removing low correlation data before analysing. As the result of our analysis by using above system, radio counterpart of EGRET identified source showed fading light-curve for a week

  3. On the evaluation of Web Radio

    OpenAIRE

    Field, A.N.; Hartel, Pieter H.

    2001-01-01

    We develop an evaluation method for Web radio, and perform it to see what we can be learnt about seven prominent Web radio sites. We also evaluate a commercial FM radio station for control purposes. We present a taxonomy of Web radio, and we give our observations and conclusions on this evaluation.

  4. Historic Radio Astronomy Working Group

    Science.gov (United States)

    2007-06-01

    This special issue of Astronomische Nachrichten contains the proceedings of a session of the Historic Radio Astronomy Working Group of the International Astronomical Union that took place during the 26th General Assembly of the IAU in Prague on 17th August 2006. In addition to the talks presented in Prague some contributions were solicited to give a more complete overview of `The Early History of European Radio Astronomy'.

  5. Radio astronomy on the moon

    International Nuclear Information System (INIS)

    Burns, J.O.; Asbell, J.

    1987-01-01

    The advantages and opportunities for radio astronomy on the moon during the early to mid 21st century are reviewed. In particular, it is argued that the lack of atmosphere, the extremely low seismic activity, the low RF background, and the natural cryogenic environment make the moon (particularly the far side and the poles) a nearly ideal locale for submillimeter/FIR to VLF (below 10 MHz) radio astronomy. 22 references

  6. Tracking Solar Type II Bursts with Space Based Radio Interferometers

    Science.gov (United States)

    Hegedus, Alexander M.; Kasper, Justin C.; Manchester, Ward B.

    2018-06-01

    The Earth’s Ionosphere limits radio measurements on its surface, blocking out any radiation below 10 MHz. Valuable insight into many astrophysical processes could be gained by having a radio interferometer in space to image the low frequency window for the first time. One application is observing type II bursts tracking solar energetic particle acceleration in Coronal Mass Ejections (CMEs). In this work we create a simulated data processing pipeline for several space based radio interferometer (SBRI) concepts and evaluate their performance in the task of localizing these type II bursts.Traditional radio astronomy software is hard coded to assume an Earth based array. To circumvent this, we manually calculate the antenna separations and insert them along with the simulated visibilities into a CASA MS file for analysis. To create the realest possible virtual input data, we take a 2-temperature MHD simulation of a CME event, superimpose realistic radio emission models from the CME-driven shock front, and propagate the signal through simulated SBRIs. We consider both probabilistic emission models derived from plasma parameters correlated with type II bursts, and analytical emission models using plasma emission wave interaction theory.One proposed SBRI is the pathfinder mission SunRISE, a 6 CubeSat interferometer to circle the Earth in a GEO graveyard orbit. We test simulated trajectories of SunRISE and image what the array recovers, comparing it to the virtual input. An interferometer on the lunar surface would be a stable alternative that avoids noise sources that affect orbiting arrays, namely the phase noise from positional uncertainty and atmospheric 10s-100s kHz noise. Using Digital Elevation Models from laser altimeter data, we test different sets of locations on the lunar surface to find near optimal configurations for tracking type II bursts far from the sun. Custom software is used to model the response of different array configurations over the lunar year

  7. RADIO WITHOUT A LISTENER: "MAYAK"

    Directory of Open Access Journals (Sweden)

    Bysko Maxim V.

    2017-12-01

    Full Text Available The singularity of this article is that it is entirely based on a critical analysis of only one live musical radio program on the Mayak radio station and dedicated to the life and work of the famous British composer Andrew Lloyd Webber. In principle, the article can be considered a scientific review of the media product. Based on his analysis, the author comes to the paradoxical conclusion that the presence of a listener becomes unnecessary for modern broadcasting. This is stated by many principles of the conduct of the air, presented in the radio program, where all the information load is placed on the guest in the studio, where there is no preparatory work of the DJs, where their inability to navigate the genres of journalism violates communication norms and colloquial ethics, where an obvious deconstructive approach to the material offered for the listener. In addition, the phenomenon of being the DJs in the radio studio exclusively "for themselves" is emphasized by the sound design of the radio program, which runs counter to the logic of auditory perception (for example, the sequence of jingles, as well as the incompetent selection of musical material, which undoubtedly repels professional radio listeners-musicians.

  8. External human induced events in site evaluation for nuclear power plants. Safety guide

    International Nuclear Information System (INIS)

    2004-01-01

    The purpose of the present Safety Guide is to provide recommendations and guidance for the examination of the region considered for site evaluation for a plant in order to identity hazardous phenomena associated with human induced events initiated by sources external to the plant. In some cases it also presents preliminary guidance for deriving values of relevant parameters for the design basis. This Safety Guide is also applicable for periodic site evaluation and site evaluation following a major human induced event, and for the design and operation of the site's environmental monitoring system. Site evaluation includes site characterization. Consideration of external events that could lead to a degradation of the safety features of the plant and cause a release of radioactive material from the plant and/or affect the dispersion of such material in the environment. And consideration of population issues and access issues significant to safety (such as the feasibility of evacuation, the population distribution and the location of resources). The process of site evaluation continues throughout the lifetime of the facility, from siting to design, construction, operation and decommissioning. The external human induced events considered in this Safety Guide are all of accidental origin. Considerations relating to the physical protection of the plant against wilful actions by third parties are outside its scope. However, the methods described herein may also have some application for the purposes of such physical protection. The present Safety Guide may also be used for events that may originate within the boundaries of the site, but from sources which are not directly involved in the operational states of the nuclear power plant units, such as fuel depots or areas for the storage of hazardous materials for the construction of other facilities at the same site. Special consideration should be given to the hazardous material handled during the construction, operation and

  9. Acoustic ambient noise recorder

    Digital Repository Service at National Institute of Oceanography (India)

    Saran, A.K.; Navelkar, G.S.; Almeida, A.M.; More, S.R.; Chodankar, P.V.; Murty, C.S.

    with a robust outfit that can withstand high pressures and chemically corrosion resistant materials. Keeping these considerations in view, a CMOS micro-controller-based marine acoustic ambient noise recorder has been developed with a real time clock...

  10. Alien Noise Cancellation

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Full FEXT Cancellation. Expectation Maximization based Algorithms. Partial Cancellation. Optimal Choice of what to Cancel and what not to! Alien Noise Cancellation. Efficient Crosstalk channel estimation. In addition:

  11. Induced Noise Control

    National Research Council Canada - National Science Library

    Maidanik, G

    2002-01-01

    The induced noise control parameter is defined in terms of the ratio of the stored energy in a master dynamic system, when it is coupled to an adjunct dynamic system, to that stored energy when the coupling is absent...

  12. The radio properties of infrared-faint radio sources

    Science.gov (United States)

    Middelberg, E.; Norris, R. P.; Hales, C. A.; Seymour, N.; Johnston-Hollitt, M.; Huynh, M. T.; Lenc, E.; Mao, M. Y.

    2011-02-01

    Context. Infrared-faint radio sources (IFRS) are objects that have flux densities of several mJy at 1.4 GHz, but that are invisible at 3.6 μm when using sensitive Spitzer observations with μJy sensitivities. Their nature is unclear and difficult to investigate since they are only visible in the radio. Aims: High-resolution radio images and comprehensive spectral coverage can yield constraints on the emission mechanisms of IFRS and can give hints to similarities with known objects. Methods: We imaged a sample of 17 IFRS at 4.8 GHz and 8.6 GHz with the Australia Telescope Compact Array to determine the structures on arcsecond scales. We added radio data from other observing projects and from the literature to obtain broad-band radio spectra. Results: We find that the sources in our sample are either resolved out at the higher frequencies or are compact at resolutions of a few arcsec, which implies that they are smaller than a typical galaxy. The spectra of IFRS are remarkably steep, with a median spectral index of -1.4 and a prominent lack of spectral indices larger than -0.7. We also find that, given the IR non-detections, the ratio of 1.4 GHz flux density to 3.6 μm flux density is very high, and this puts them into the same regime as high-redshift radio galaxies. Conclusions: The evidence that IFRS are predominantly high-redshift sources driven by active galactic nuclei (AGN) is strong, even though not all IFRS may be caused by the same phenomenon. Compared to the rare and painstakingly collected high-redshift radio galaxies, IFRS appear to be much more abundant, but less luminous, AGN-driven galaxies at similar cosmological distances.

  13. Information Content in Radio Waves: Student Investigations in Radio Science

    Science.gov (United States)

    Jacobs, K.; Scaduto, T.

    2013-12-01

    We describe an inquiry-based instructional unit on information content in radio waves, created in the summer of 2013 as part of a MIT Haystack Observatory (Westford, MA) NSF Research Experiences for Teachers (RET) program. This topic is current and highly relevant, addressing science and technical aspects from radio astronomy, geodesy, and atmospheric research areas as well as Next Generation Science Standards (NGSS). Projects and activities range from simple classroom demonstrations and group investigations, to long term research projects incorporating data acquisition from both student-built instrumentation as well as online databases. Each of the core lessons is applied to one of the primary research centers at Haystack through an inquiry project that builds on previously developed units through the MIT Haystack RET program. In radio astronomy, students investigate the application of a simple and inexpensive software defined radio chip (RTL-SDR) for use in systems implementing a small and very small radio telescope (SRT and VSRT). Both of these systems allow students to explore fundamental principles of radio waves and interferometry as applied to radio astronomy. In ionospheric research, students track solar storms from the initial coronal mass ejection (using Solar Dynamics Observatory images) to the resulting variability in total electron density concentrations using data from the community standard Madrigal distributed database system maintained by MIT Haystack. Finally, students get to explore very long-baseline interferometry as it is used in geodetic studies by measuring crustal plate displacements over time. Alignment to NextGen standards is provided for each lesson and activity with emphasis on HS-PS4 'Waves and Their Applications in Technologies for Information Transfer'.

  14. Approximations to camera sensor noise

    Science.gov (United States)

    Jin, Xiaodan; Hirakawa, Keigo

    2013-02-01

    Noise is present in all image sensor data. Poisson distribution is said to model the stochastic nature of the photon arrival process, while it is common to approximate readout/thermal noise by additive white Gaussian noise (AWGN). Other sources of signal-dependent noise such as Fano and quantization also contribute to the overall noise profile. Question remains, however, about how best to model the combined sensor noise. Though additive Gaussian noise with signal-dependent noise variance (SD-AWGN) and Poisson corruption are two widely used models to approximate the actual sensor noise distribution, the justification given to these types of models are based on limited evidence. The goal of this paper is to provide a more comprehensive characterization of random noise. We concluded by presenting concrete evidence that Poisson model is a better approximation to real camera model than SD-AWGN. We suggest further modification to Poisson that may improve the noise model.

  15. Noise frame duration, masking potency and whiteness of temporal noise.

    Science.gov (United States)

    Kukkonen, Heljä; Rovamo, Jyrki; Donner, Kristian; Tammikallio, Marja; Raninen, Antti

    2002-09-01

    Because of the limited contrast range, increasing the duration of the noise frame is often the only option for increasing the masking potency of external, white temporal noise. This, however, reduces the high-frequency cutoff beyond which noise is no longer white. This study was conducted to determine the longest noise frame duration that produces the strongest masking effect and still mimics white noise on the detection of sinusoidal flicker. Contrast energy thresholds (E(th)) were measured for flicker at 1.25 to 20 Hz in strong, purely temporal (spatially uniform), additive, external noise. The masking power of white external noise, characterized by its spectral density at zero frequency N0, increases with the duration of the noise frame. For short noise frame durations, E(th) increased in direct proportion to N0, keeping the nominal signal-to-noise ratio [SNR = (E(th)/N0)(0.5)] constant at threshold. The masking effect thus increased with the duration of the noise frame and the noise mimicked white noise. When noise frame duration and N0 increased further, the nominal SNR at threshold started to decrease, indicating that noise no longer mimicked white noise. The minimum number of noise frames per flicker cycle needed to mimic white noise decreased with increasing flicker frequency from 8.3 at 1.25 Hz to 1.6 at 20 Hz. The critical high-frequency cutoff of detection-limiting temporal noise in terms of noise frames per signal cycle depends on the temporal frequency of the signal. This is opposite to the situation in the spatial domain and must be taken into consideration when temporal signals are masked with temporal noise.

  16. Active noise control primer

    CERN Document Server

    Snyder, Scott D

    2000-01-01

    Active noise control - the reduction of noise by generating an acoustic signal that actively interferes with the noise - has become an active area of basic research and engineering applications. The aim of this book is to present all of the basic knowledge one needs for assessing how useful active noise control will be for a given problem and then to provide some guidance for designing, setting up, and tuning an active noise-control system. Written for students who have no prior knowledge of acoustics, signal processing, or noise control but who do have a reasonable grasp of basic physics and mathematics, the book is short and descriptive. It leaves for more advanced texts or research monographs all mathematical details and proofs concerning vibrations, signal processing and the like. The book can thus be used in independent study, in a classroom with laboratories, or in conjunction with a kit for experiment or demonstration. Topics covered include: basic acoustics; human perception and sound; sound intensity...

  17. Power reactor noise

    International Nuclear Information System (INIS)

    Thie, J.A.

    1981-01-01

    This book concentrates on the different types of noise present in power reactors and how the analysis of this noise can be used as a tool for reactor monitoring and diagnostics. Noise analysis is a growing field that offers advantages such as simplicity, low cost, and natural multivariable interactions. A major advantage, continuous and undisturbed monitoring, supplies a means of obtaining early warnings of possible reactor malfunctions thus preventing further complications by alerting operators to a problem - and aiding in the diagnosis of that problem - before it demands major repairs. Following an introductory chapter, the theoretical basis for the various methods of noise analysis is explained, and full chapters are devoted to the fundamentals of statistics for time-domain analysis and Fourier series and related topics for frequency-domain analysis. General experimental techniques and associated theoretical considerations are reviewed, leading to discussion of practical applications in the latter half of the book. Besides chapters giving examples of neutron noise and acoustical noise, chapters are also devoted to extensive examples from pressurized water reactor and boiling water reactor power plants

  18. Phase noise in RF and microwave amplifiers.

    Science.gov (United States)

    Boudot, Rodolphe; Rubiola, Enrico

    2012-12-01

    Understanding amplifier phase noise is a critical issue in many fields of engineering and physics, such as oscillators, frequency synthesis, telecommunication, radar, and spectroscopy; in the emerging domain of microwave photonics; and in exotic fields, such as radio astronomy, particle accelerators, etc. Focusing on the two main types of base noise in amplifiers, white and flicker, the power spectral density of the random phase φ(t) is Sφ(f) = b(0) + b(-1)/f. White phase noise results from adding white noise to the RF spectrum in the carrier region. For a given RF noise level, b(0) is proportional to the reciprocal of the carrier power P(0). By contrast, flicker results from a near-dc 1/f noise-present in all electronic devices-which modulates the carrier through some parametric effect in the semiconductor. Thus, b(-1) is a parameter of the amplifier, constant in a wide range of P(0). The consequences are the following: Connecting m equal amplifiers in parallel, b(-1) is 1/m times that of one device. Cascading m equal amplifiers, b(-1) is m times that of one amplifier. Recirculating the signal in an amplifier so that the gain increases by a power of m (a factor of m in decibels) as a result of positive feedback (regeneration), we find that b(-1) is m(2) times that of the amplifier alone. The feedforward amplifier exhibits extremely low b(-1) because the carrier is ideally nulled at the input of its internal error amplifier. Starting with an extensive review of the literature, this article introduces a system-oriented model which describes the phase flickering. Several amplifier architectures (cascaded, parallel, etc.) are analyzed systematically, deriving the phase noise from the general model. There follow numerous measurements of amplifiers using different technologies, including some old samples, and in a wide frequency range (HF to microwaves), which validate the theory. In turn, theory and results provide design guidelines and give suggestions for CAD and

  19. Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters

    NARCIS (Netherlands)

    Shinnawi, Rami; Huber, Irit; Maizels, Leonid; Shaheen, Naim; Gepstein, Amira; Arbel, Gil; Tijsen, Anke J.; Gepstein, Lior

    2015-01-01

    The advent of the human-induced pluripotent stem cell (hiPSC) technology has transformed biomedical research, providing new tools for human disease modeling, drug development, and regenerative medicine. To fulfill its unique potential in the cardiovascular field, efficient methods should be

  20. Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells

    DEFF Research Database (Denmark)

    Aldana, Blanca I; Zhang, Yu; Lihme, Maria Fog

    2017-01-01

    pathways in neurons derived from human induced pluripotent stem cells (hiPSC). With this aim, cultures of hiPSC-derived neurons were incubated with [U-(13)C]glucose, [U-(13)C]glutamate or [U-(13)C]glutamine. Isotopic labeling in metabolites was determined using gas chromatography coupled to mass...

  1. ON THE USE OF SHOT NOISE FOR PHOTON COUNTING

    Energy Technology Data Exchange (ETDEWEB)

    Zmuidzinas, Jonas, E-mail: jonas@caltech.edu [Division of Physics, Mathematics, and Astronomy, California Institute Institute of Technology, Pasadena, CA 91125 (United States)

    2015-11-01

    Lieu et al. have recently claimed that it is possible to substantially improve the sensitivity of radio-astronomical observations. In essence, their proposal is to make use of the intensity of the photon shot noise as a measure of the photon arrival rate. Lieu et al. provide a detailed quantum-mechanical calculation of a proposed measurement scheme that uses two detectors and conclude that this scheme avoids the sensitivity degradation that is associated with photon bunching. If correct, this result could have a profound impact on radio astronomy. Here I present a detailed analysis of the sensitivity attainable using shot-noise measurement schemes that use either one or two detectors, and demonstrate that neither scheme can avoid the photon bunching penalty. I perform both semiclassical and fully quantum calculations of the sensitivity, obtaining consistent results, and provide a formal proof of the equivalence of these two approaches. These direct calculations are furthermore shown to be consistent with an indirect argument based on a correlation method that establishes an independent limit to the sensitivity of shot-noise measurement schemes. Furthermore, these calculations are directly applicable to the regime of interest identified by Lieu et al. Collectively, these results conclusively demonstrate that the photon-bunching sensitivity penalty applies to shot-noise measurement schemes just as it does to ordinary photon counting, in contradiction to the fundamental claim made by Lieu et al. The source of this contradiction is traced to a logical fallacy in their argument.

  2. Robust Differentiation of mRNA-Reprogrammed Human Induced Pluripotent Stem Cells Toward a Retinal Lineage.

    Science.gov (United States)

    Sridhar, Akshayalakshmi; Ohlemacher, Sarah K; Langer, Kirstin B; Meyer, Jason S

    2016-04-01

    The derivation of human induced pluripotent stem cells (hiPSCs) from patient-specific sources has allowed for the development of novel approaches to studies of human development and disease. However, traditional methods of generating hiPSCs involve the risks of genomic integration and potential constitutive expression of pluripotency factors and often exhibit low reprogramming efficiencies. The recent description of cellular reprogramming using synthetic mRNA molecules might eliminate these shortcomings; however, the ability of mRNA-reprogrammed hiPSCs to effectively give rise to retinal cell lineages has yet to be demonstrated. Thus, efforts were undertaken to test the ability and efficiency of mRNA-reprogrammed hiPSCs to yield retinal cell types in a directed, stepwise manner. hiPSCs were generated from human fibroblasts via mRNA reprogramming, with parallel cultures of isogenic human fibroblasts reprogrammed via retroviral delivery of reprogramming factors. New lines of mRNA-reprogrammed hiPSCs were established and were subsequently differentiated into a retinal fate using established protocols in a directed, stepwise fashion. The efficiency of retinal differentiation from these lines was compared with retroviral-derived cell lines at various stages of development. On differentiation, mRNA-reprogrammed hiPSCs were capable of robust differentiation to a retinal fate, including the derivation of photoreceptors and retinal ganglion cells, at efficiencies often equal to or greater than their retroviral-derived hiPSC counterparts. Thus, given that hiPSCs derived through mRNA-based reprogramming strategies offer numerous advantages owing to the lack of genomic integration or constitutive expression of pluripotency genes, such methods likely represent a promising new approach for retinal stem cell research, in particular, those for translational applications. In the current report, the ability to derive mRNA-reprogrammed human induced pluripotent stem cells (hi

  3. How widespread is human-induced seismicity in the USA and Canada?

    Science.gov (United States)

    Van der Baan, M.

    2017-12-01

    There has been significant public and scientific interest in the observation of changed seismicity rates in North America since 2008, possibly due to human activities. Van der Baan and Calixto (2017) find that the seismicity rate in Oklahoma between 2008 and 2016 is strongly correlated to increased hydrocarbon production. The possibility of systematic correlations between increased hydrocarbon production and seismicity rates is a pertinent question since the USA became the world's largest hydrocarbon producer in 2013, surpassing both Saudi Arabia's oil production and Russia's dry gas production. In most areas increased production is due to systematic hydraulic fracturing which involves high-pressure, underground fluid injection. Increased hydrocarbon production also leads to increased salt-water production which is often disposed of underground. Increased underground fluid injection in general may cause increased seismicity rates due to facilitated slip on pre-existing faults. Contrary to Oklahoma, analysis of oil and gas production versus seismicity rates in six other States in the USA and three provinces in Canada finds no State/Province-wide correlation between increased seismicity and hydrocarbon production, despite 8-16 fold increases in production in some States (Van der Baan and Calixto, 2017). However, in various areas, seismicity rates have increased locally. A comparison with seismic hazard maps shows that human-induced seismicity is less likely in areas that have historically felt fewer earthquakes. The opposite is not necessarily true. ReferencesVan der Baan, M. and Calixto, F. J. (2017), Human-induced seismicity and large-scale hydrocarbon production in the USA and Canada. Geochem. Geophys. Geosyst., 18, doi:10.1002/2017GC006915 AcknowledgmentsThe author thanks Frank Calixto who co-authored the paper on which a large portion of this lecture is based, the sponsors of the Microseismic Industry Consortium for financial support, the SEG for funding and

  4. Radio Frequency Interference Site Survey for Thai Radio Telescopes

    Science.gov (United States)

    Jaroenjittichai, P.; Punyawarin, S.; Singwong, D.; Somboonpon, P.; Prasert, N.; Bandudej, K.; Kempet, P.; Leckngam, A.; Poshyachinda, S.; Soonthornthum, B.; Kramer, B.

    2017-09-01

    Radio astronomical observations have increasingly been threaten by the march of today telecommunication and wireless technology. Performance of radio telescopes lies within the fact that astronomical sources are extremely weak. National Astronomy Research Institute of Thailand (NARIT) has initiated a 5-year project, known as the Radio Astronomy Network and Geodesy for Development (RANGD), which includes the establishment of 40-meter and 13-meter radio telescopes. Possible locations have been narrowed down to three candidates, situated in the Northern part of Thailand, where the atmosphere is sufficiently dry and suitable for 22 and 43 GHz observations. The Radio Frequency Interference (RFI) measurements were carried out with a DC spectrum analyzer and directional antennas at 1.5 meter above ground, from 20 MHz to 6 GHz with full azimuth coverage. The data from a 3-minute pointing were recorded for both horizontal and vertical polarizations, in maxhold and average modes. The results, for which we used to make preliminary site selection, show signals from typical broadcast and telecommunication services and aeronautics applications. The signal intensity varies accordingly to the presence of nearby population and topography of the region.

  5. Noise frame duration, masking potency and whiteness of temporal noise

    OpenAIRE

    Kukkonen, Helja; Rovamo, Jyrki; Donner, Kristian; Tammikallio, Marja; Raninen, Antii

    2002-01-01

    PURPOSE. Because of the limited contrast range, increasing the duration of the noise frame is often the only option for increasing the masking potency of external, white temporal noise. This, however, reduces the high-frequency cutoff beyond which noise is no longer white. This study was conducted to determine the longest noise frame duration that produces the strongest masking effect and still mimics white noise on the detection of sinusoidal flicker. \\ud \\ud METHODS. Contrast energy thresho...

  6. Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells.

    Science.gov (United States)

    Lee, Yee-Ki; Lau, Yee-Man; Cai, Zhu-Jun; Lai, Wing-Hon; Wong, Lai-Yung; Tse, Hung-Fat; Ng, Kwong-Man; Siu, Chung-Wah

    2017-07-28

    Precision medicine is an emerging approach to disease treatment and prevention that takes into account individual variability in the environment, lifestyle, and genetic makeup of patients. Patient-specific human induced pluripotent stem cells hold promise to transform precision medicine into real-life clinical practice. Lamin A/C (LMNA)-related cardiomyopathy is the most common inherited cardiomyopathy in which a substantial proportion of mutations in the LMNA gene are of nonsense mutation. PTC124 induces translational read-through over the premature stop codon and restores production of the full-length proteins from the affected genes. In this study we generated human induced pluripotent stem cells-derived cardiomyocytes from patients who harbored different LMNA mutations (nonsense and frameshift) to evaluate the potential therapeutic effects of PTC124 in LMNA -related cardiomyopathy. We generated human induced pluripotent stem cells lines from 3 patients who carried distinctive mutations (R225X, Q354X, and T518fs) in the LMNA gene. The cardiomyocytes derived from these human induced pluripotent stem cells lines reproduced the pathophysiological hallmarks of LMNA -related cardiomyopathy. Interestingly, PTC124 treatment increased the production of full-length LMNA proteins in only the R225X mutant, not in other mutations. Functional evaluation experiments on the R225X mutant further demonstrated that PTC124 treatment not only reduced nuclear blebbing and electrical stress-induced apoptosis but also improved the excitation-contraction coupling of the affected cardiomyocytes. Using cardiomyocytes derived from human induced pluripotent stem cells carrying different LMNA mutations, we demonstrated that the effect of PTC124 is codon selective. A premature stop codon UGA appeared to be most responsive to PTC124 treatment. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

  7. Resource Allocation for Cloud Radio Access Networks

    KAUST Repository

    Dhifallah, Oussama

    2016-04-01

    Cloud-radio access network (CRAN) is expected to be the core network architecture for next generation mobile radio system. In CRANs, joint signal processing is performed at multiple cloud computing centers (clouds) that are connected to several base stations (BSs) via high capacity backhaul links. As a result, large-scale interference management and network power consumption reduction can be effectively achieved. Unlike recent works on CRANs which consider a single cloud processing and treat inter-cloud interference as background noise, the first part of this thesis focuses on the more practical scenario of the downlink of a multi-cloud radio access network where BSs are connected to each cloud through wireline backhaul links. Assume that each cloud serves a set of pre-known single-antenna mobile users (MUs). This part focuses on minimizing the network total power consumption subject to practical constraints. The problems are solved using sophisticated techniques from optimization theory (e.g. Dual Decomposition-based algorithm and the alternating direction method of multipliers (ADMM)-based algorithm). One highlight of this part is that the proposed solutions can be implemented in a distributed fashion by allowing a reasonable information exchange between the coupled clouds. Additionally, feasible solutions of the considered optimization problems can be estimated locally at each iteration. Simulation results show that the proposed distributed algorithms converge to the centralized algorithms in a reasonable number of iterations. To further account of the backhaul congestion due to densification in CRANs, the second part of this thesis considers the downlink of a cache-enabled CRAN where each BS is equipped with a local-cache with limited size used to store the popular files without the need for backhauling. Further, each cache-enabled BS is connected to the cloud via limited capacity backhaul link and can serve a set of pre-known single antenna MUs. This part

  8. Generalised shot noise Cox processes

    DEFF Research Database (Denmark)

    Møller, Jesper; Torrisi, Giovanni Luca

    2005-01-01

    We introduce a class of cox cluster processes called generalised shot noise Cox processes (GSNCPs), which extends the definition of shot noise Cox processes (SNCPs) in two directions: the point process that drives the shot noise is not necessarily Poisson, and the kernel of the shot noise can...

  9. IA-Regional-Radio - Social Network for Radio Recommendation

    Science.gov (United States)

    Dziczkowski, Grzegorz; Bougueroua, Lamine; Wegrzyn-Wolska, Katarzyna

    This chapter describes the functions of a system proposed for the music hit recommendation from social network data base. This system carries out the automatic collection, evaluation and rating of music reviewers and the possibility for listeners to rate musical hits and recommendations deduced from auditor's profiles in the form of regional Internet radio. First, the system searches and retrieves probable music reviews from the Internet. Subsequently, the system carries out an evaluation and rating of those reviews. From this list of music hits, the system directly allows notation from our application. Finally, the system automatically creates the record list diffused each day depending on the region, the year season, the day hours and the age of listeners. Our system uses linguistics and statistic methods for classifying music opinions and data mining techniques for recommendation part needed for recorded list creation. The principal task is the creation of popular intelligent radio adaptive on auditor's age and region - IA-Regional-Radio.

  10. Ketamine Causes Mitochondrial Dysfunction in Human Induced Pluripotent Stem Cell-Derived Neurons

    Science.gov (United States)

    Ito, Hiroyuki; Uchida, Tokujiro; Makita, Koshi

    2015-01-01

    Purpose Ketamine toxicity has been demonstrated in nonhuman mammalian neurons. To study the toxic effect of ketamine on human neurons, an experimental model of cultured neurons from human induced pluripotent stem cells (iPSCs) was examined, and the mechanism of its toxicity was investigated. Methods Human iPSC-derived dopaminergic neurons were treated with 0, 20, 100 or 500 μM ketamine for 6 and 24 h. Ketamine toxicity was evaluated by quantification of caspase 3/7 activity, reactive oxygen species (ROS) production, mitochondrial membrane potential, ATP concentration, neurotransmitter reuptake activity and NADH/NAD+ ratio. Mitochondrial morphological change was analyzed by transmission electron microscopy and confocal microscopy. Results Twenty-four-hour exposure of iPSC-derived neurons to 500 μM ketamine resulted in a 40% increase in caspase 3/7 activity (P ketamine (100 μM) decreased the ATP level (22%, P ketamine concentration, which suggests that mitochondrial dysfunction preceded ROS generation and caspase activation. Conclusions We established an in vitro model for assessing the neurotoxicity of ketamine in iPSC-derived neurons. The present data indicate that the initial mitochondrial dysfunction and autophagy may be related to its inhibitory effect on the mitochondrial electron transport system, which underlies ketamine-induced neural toxicity. Higher ketamine concentration can induce ROS generation and apoptosis in human neurons. PMID:26020236

  11. Physiological evidence for a human-induced landscape of fear in brown bears (Ursus arctos).

    Science.gov (United States)

    Støen, Ole-Gunnar; Ordiz, Andres; Evans, Alina L; Laske, Timothy G; Kindberg, Jonas; Fröbert, Ole; Swenson, Jon E; Arnemo, Jon M

    2015-12-01

    Human persecution is a major cause of mortality for large carnivores. Consequently, large carnivores avoid humans, but may use human-dominated landscapes by being nocturnal and elusive. Behavioral studies indicate that certain ecological systems are "landscapes of fear", driven by antipredator behavior. Because behavior and physiology are closely interrelated, physiological assessments may provide insight into the behavioral response of large carnivores to human activity. To elucidate changes in brown bears' (Ursus arctos) behavior associated with human activity, we evaluated stress as changes in heart rate (HR) and heart rate variability (HRV) in 12 GPS-collared, free-ranging bears, 7 males and 5 females, 3-11 years old, using cardiac-monitoring devices. We applied generalized linear regression models with HR and HRV as response variables and chest activity, time of day, season, distance traveled, and distance to human settlements from GPS positions recorded every 30 min as potential explanatory variables. Bears exhibited lower HRV, an indication of stress, when they were close to human settlements and especially during the berry season, when humans were more often in the forest, picking berries and hunting. Our findings provide evidence of a human-induced landscape of fear in this hunted population of brown bears. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  12. Different Chondrogenic Potential among Human Induced Pluripotent Stem Cells from Diverse Origin Primary Cells

    Directory of Open Access Journals (Sweden)

    Yeri Alice Rim

    2018-01-01

    Full Text Available Scientists have tried to reprogram various origins of primary cells into human induced pluripotent stem cells (hiPSCs. Every somatic cell can theoretically become a hiPSC and give rise to targeted cells of the human body. However, there have been debates on the controversy about the differentiation propensity according to the origin of primary cells. We reprogrammed hiPSCs from four different types of primary cells such as dermal fibroblasts (DF, n=3, peripheral blood mononuclear cells (PBMC, n=3, cord blood mononuclear cells (CBMC, n=3, and osteoarthritis fibroblast-like synoviocytes (OAFLS, n=3. Established hiPSCs were differentiated into chondrogenic pellets. All told, cartilage-specific markers tended to express more by the order of CBMC > DF > PBMC > FLS. Origin of primary cells may influence the reprogramming and differentiation thereafter. In the context of chondrogenic propensity, CBMC-derived hiPSCs can be a fairly good candidate cell source for cartilage regeneration. The differentiation of hiPSCs into chondrocytes may help develop “cartilage in a dish” in the future. Also, the ideal cell source of hiPSC for chondrogenesis may contribute to future application as well.

  13. Demographics of an ornate box turtle population experiencing minimal human-induced disturbances

    Science.gov (United States)

    Converse, S.J.; Iverson, J.B.; Savidge, J.A.

    2005-01-01

    Human-induced disturbances may threaten the viability of many turtle populations, including populations of North American box turtles. Evaluation of the potential impacts of these disturbances can be aided by long-term studies of populations subject to minimal human activity. In such a population of ornate box turtles (Terrapene ornata ornata) in western Nebraska, we examined survival rates and population growth rates from 1981-2000 based on mark-recapture data. The average annual apparent survival rate of adult males was 0.883 (SE = 0.021) and of adult females was 0.932 (SE = 0.014). Minimum winter temperature was the best of five climate variables as a predictor of adult survival. Survival rates were highest in years with low minimum winter temperatures, suggesting that global warming may result in declining survival. We estimated an average adult population growth rate (????) of 1.006 (SE = 0.065), with an estimated temporal process variance (????2) of 0.029 (95% CI = 0.005-0.176). Stochastic simulations suggest that this mean and temporal process variance would result in a 58% probability of a population decrease over a 20-year period. This research provides evidence that, unless unknown density-dependent mechanisms are operating in the adult age class, significant human disturbances, such as commercial harvest or turtle mortality on roads, represent a potential risk to box turtle populations. ?? 2005 by the Ecological Society of America.

  14. CRISPR-Cas9-Based Genome Editing of Human Induced Pluripotent Stem Cells.

    Science.gov (United States)

    Giacalone, Joseph C; Sharma, Tasneem P; Burnight, Erin R; Fingert, John F; Mullins, Robert F; Stone, Edwin M; Tucker, Budd A

    2018-02-28

    Human induced pluripotent stem cells (hiPSCs) are the ideal cell source for autologous cell replacement. However, for patients with Mendelian diseases, genetic correction of the original disease-causing mutation is likely required prior to cellular differentiation and transplantation. The emergence of the CRISPR-Cas9 system has revolutionized the field of genome editing. By introducing inexpensive reagents that are relatively straightforward to design and validate, it is now possible to correct genetic variants or insert desired sequences at any location within the genome. CRISPR-based genome editing of patient-specific iPSCs shows great promise for future autologous cell replacement therapies. One caveat, however, is that hiPSCs are notoriously difficult to transfect, and optimized experimental design considerations are often necessary. This unit describes design strategies and methods for efficient CRISPR-based genome editing of patient- specific iPSCs. Additionally, it details a flexible approach that utilizes positive selection to generate clones with a desired genomic modification, Cre-lox recombination to remove the integrated selection cassette, and negative selection to eliminate residual hiPSCs with intact selection cassettes. © 2018 by John Wiley & Sons, Inc. Copyright © 2018 John Wiley & Sons, Inc.

  15. Disease Modeling Using 3D Organoids Derived from Human Induced Pluripotent Stem Cells.

    Science.gov (United States)

    Ho, Beatrice Xuan; Pek, Nicole Min Qian; Soh, Boon-Seng

    2018-03-21

    The rising interest in human induced pluripotent stem cell (hiPSC)-derived organoid culture has stemmed from the manipulation of various combinations of directed multi-lineage differentiation and morphogenetic processes that mimic organogenesis. Organoids are three-dimensional (3D) structures that are comprised of multiple cell types, self-organized to recapitulate embryonic and tissue development in vitro. This model has been shown to be superior to conventional two-dimensional (2D) cell culture methods in mirroring functionality, architecture, and geometric features of tissues seen in vivo. This review serves to highlight recent advances in the 3D organoid technology for use in modeling complex hereditary diseases, cancer, host-microbe interactions, and possible use in translational and personalized medicine where organoid cultures were used to uncover diagnostic biomarkers for early disease detection via high throughput pharmaceutical screening. In addition, this review also aims to discuss the advantages and shortcomings of utilizing organoids in disease modeling. In summary, studying human diseases using hiPSC-derived organoids may better illustrate the processes involved due to similarities in the architecture and microenvironment present in an organoid, which also allows drug responses to be properly recapitulated in vitro.

  16. Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells.

    Science.gov (United States)

    Byrne, Susan M; Ortiz, Luis; Mali, Prashant; Aach, John; Church, George M

    2015-02-18

    Sequence-specific nucleases such as TALEN and the CRISPR/Cas9 system have so far been used to disrupt, correct or insert transgenes at precise locations in mammalian genomes. We demonstrate efficient 'knock-in' targeted replacement of multi-kilobase genes in human induced pluripotent stem cells (iPSC). Using a model system replacing endogenous human genes with their mouse counterpart, we performed a comprehensive study of targeting vector design parameters for homologous recombination. A 2.7 kilobase (kb) homozygous gene replacement was achieved in up to 11% of iPSC without selection. The optimal homology arm length was around 2 kb, with homology length being especially critical on the arm not adjacent to the cut site. Homologous sequence inside the cut sites was detrimental to targeting efficiency, consistent with a synthesis-dependent strand annealing (SDSA) mechanism. Using two nuclease sites, we observed a high degree of gene excisions and inversions, which sometimes occurred more frequently than indel mutations. While homozygous deletions of 86 kb were achieved with up to 8% frequency, deletion frequencies were not solely a function of nuclease activity and deletion size. Our results analyzing the optimal parameters for targeting vector design will inform future gene targeting efforts involving multi-kilobase gene segments, particularly in human iPSC. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  17. May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells.

    Science.gov (United States)

    Brookhouser, Nicholas; Raman, Sreedevi; Potts, Christopher; Brafman, David A

    2017-02-06

    In the decade since Yamanaka and colleagues described methods to reprogram somatic cells into a pluripotent state, human induced pluripotent stem cells (hiPSCs) have demonstrated tremendous promise in numerous disease modeling, drug discovery, and regenerative medicine applications. More recently, the development and refinement of advanced gene transduction and editing technologies have further accelerated the potential of hiPSCs. In this review, we discuss the various gene editing technologies that are being implemented with hiPSCs. Specifically, we describe the emergence of technologies including zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 that can be used to edit the genome at precise locations, and discuss the strengths and weaknesses of each of these technologies. In addition, we present the current applications of these technologies in elucidating the mechanisms of human development and disease, developing novel and effective therapeutic molecules, and engineering cell-based therapies. Finally, we discuss the emerging technological advances in targeted gene editing methods.

  18. Gamma Spectrometry for Chronology of Recent Sediments. Tracing Human Induced Climate Change in NW Africa

    Energy Technology Data Exchange (ETDEWEB)

    Pittauerova, D.; Fischer, H. W. [Institute of Environmental Physics, University of Bremen, Bremen (Germany); Mulitza, S. [MARUM - Center for Marine Environmental Sciences, University of Bremen, (Germany)

    2013-07-15

    Gamma spectroscopy was used for the determination of radionuclides in sediment cores from the continental shelf off northwest africa to provide age control of the sediment record used for a study of aridification of the Sahel zone. {sup 210}Pb, {sup 226}Ra and {sup 137}Cs were measured in the upper part of a gravity core and the associated multicorer and used for aligning these cores. This provided information about the amount of sediment loss due to the sampling procedure in the upper part of the gravity core. The age model based on the matched profiles extended to 140 years B.P. and the rest of the gravity core was dated by {sup 14}C. The {sup 210}Pb age allowed the estimation of the local radiocarbon reservoir age. Application of {sup 210}Pb and {sup 137}Cs chronology helps to significantly extend paleoclimatic proxy data into the Anthropocene, thereby allowing the comparison of human induced climate change with natural climate variability. (author)

  19. Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells.

    Science.gov (United States)

    Drawnel, Faye M; Boccardo, Stefano; Prummer, Michael; Delobel, Frédéric; Graff, Alexandra; Weber, Michael; Gérard, Régine; Badi, Laura; Kam-Thong, Tony; Bu, Lei; Jiang, Xin; Hoflack, Jean-Christophe; Kiialainen, Anna; Jeworutzki, Elena; Aoyama, Natsuyo; Carlson, Coby; Burcin, Mark; Gromo, Gianni; Boehringer, Markus; Stahlberg, Henning; Hall, Benjamin J; Magnone, Maria Chiara; Kolaja, Kyle; Chien, Kenneth R; Bailly, Jacques; Iacone, Roberto

    2014-11-06

    Diabetic cardiomyopathy is a complication of type 2 diabetes, with known contributions of lifestyle and genetics. We develop environmentally and genetically driven in vitro models of the condition using human-induced-pluripotent-stem-cell-derived cardiomyocytes. First, we mimic diabetic clinical chemistry to induce a phenotypic surrogate of diabetic cardiomyopathy, observing structural and functional disarray. Next, we consider genetic effects by deriving cardiomyocytes from two diabetic patients with variable disease progression. The cardiomyopathic phenotype is recapitulated in the patient-specific cells basally, with a severity dependent on their original clinical status. These models are incorporated into successive levels of a screening platform, identifying drugs that preserve cardiomyocyte phenotype in vitro during diabetic stress. In this work, we present a patient-specific induced pluripotent stem cell (iPSC) model of a complex metabolic condition, showing the power of this technique for discovery and testing of therapeutic strategies for a disease with ever-increasing clinical significance. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  20. Electrical Stimulation Promotes Cardiac Differentiation of Human Induced Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Damián Hernández

    2016-01-01

    Full Text Available Background. Human induced pluripotent stem cells (iPSCs are an attractive source of cardiomyocytes for cardiac repair and regeneration. In this study, we aim to determine whether acute electrical stimulation of human iPSCs can promote their differentiation to cardiomyocytes. Methods. Human iPSCs were differentiated to cardiac cells by forming embryoid bodies (EBs for 5 days. EBs were then subjected to brief electrical stimulation and plated down for 14 days. Results. In iPS(Foreskin-2 cell line, brief electrical stimulation at 65 mV/mm or 200 mV/mm for 5 min significantly increased the percentage of beating EBs present by day 14 after plating. Acute electrical stimulation also significantly increased the cardiac gene expression of ACTC1, TNNT2, MYH7, and MYL7. However, the cardiogenic effect of electrical stimulation was not reproducible in another iPS cell line, CERA007c6. Beating EBs from control and electrically stimulated groups expressed various cardiac-specific transcription factors and contractile muscle markers. Beating EBs were also shown to cycle calcium and were responsive to the chronotropic agents, isoproterenol and carbamylcholine, in a concentration-dependent manner. Conclusions. Our results demonstrate that brief electrical stimulation can promote cardiac differentiation of human iPS cells. The cardiogenic effect of brief electrical stimulation is dependent on the cell line used.

  1. Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells.

    Science.gov (United States)

    Yamashita, Tomoki; Takayama, Kazuo; Sakurai, Fuminori; Mizuguchi, Hiroyuki

    2018-02-19

    Human induced pluripotent stem (iPS) cell-derived hepatocyte-like cells are expected to be utilized in drug screening and regenerative medicine. However, hepatocyte-like cells have not been fully used in such applications because it is difficult to produce such cells on a large scale. In this study, we tried to establish a method to mass produce hepatocyte-like cells using a three-dimensional (3D) cell culture bioreactor called the Rotary Cell Culture System (RCCS). RCCS enabled us to obtain homogenous hepatocyte-like cells on a billion scale (>10 9  cells). The gene expression levels of some hepatocyte markers (alpha-1 antitrypsin, cytochrome (CYP) 1A2, CYP2D6, and hepatocyte nuclear factor 4alpha) were higher in 3D-cultured hepatocyte-like cells than in 2D-cultured hepatocyte-like cells. This result suggests that RCCS could provide more suitable conditions for hepatocyte maturation than the conventional 2D cell culture conditions. In addition, more than 90% of hepatocyte-like cells were positive for albumin and could uptake low-density lipoprotein in the culture medium. We succeeded in the large-scale production of homogenous and functional hepatocyte-like cells from human iPS cells. This technology will be useful in drug screening and regenerative medicine, which require enormous numbers of hepatocyte-like cells. Copyright © 2018 Elsevier Inc. All rights reserved.

  2. Human-Induced Pluripotent Stem Cell Technology and Cardiomyocyte Generation: Progress and Clinical Applications

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    Angela Di Baldassarre

    2018-05-01

    Full Text Available Human-induced pluripotent stem cells (hiPSCs are reprogrammed cells that have hallmarks similar to embryonic stem cells including the capacity of self-renewal and differentiation into cardiac myocytes. The improvements in reprogramming and differentiating methods achieved in the past 10 years widened the use of hiPSCs, especially in cardiac research. hiPSC-derived cardiac myocytes (CMs recapitulate phenotypic differences caused by genetic variations, making them attractive human disease models and useful tools for drug discovery and toxicology testing. In addition, hiPSCs can be used as sources of cells for cardiac regeneration in animal models. Here, we review the advances in the genetic and epigenetic control of cardiomyogenesis that underlies the significant improvement of the induced reprogramming of somatic cells to CMs; the methods used to improve scalability of throughput assays for functional screening and drug testing in vitro; the phenotypic characteristics of hiPSCs-derived CMs and their ability to rescue injured CMs through paracrine effects; we also cover the novel approaches in tissue engineering for hiPSC-derived cardiac tissue generation, and finally, their immunological features and the potential use in biomedical applications.

  3. Application of human induced pluripotent stem cells to model fibrodysplasia ossificans progressiva.

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    Barruet, Emilie; Hsiao, Edward C

    2018-04-01

    Fibrodysplasia ossificans progressiva (FOP) is a genetic condition characterized by massive heterotopic ossification. FOP patients have mutations in the Activin A type I receptor (ACVR1), a bone morphogenetic protein (BMP) receptor. FOP is a progressive and debilitating disease characterized by bone formation flares that often occur after trauma. Since it is often difficult or impossible to obtain large amounts of tissue from human donors due to the risks of inciting more heterotopic bone formation, human induced pluripotent stem cells (hiPSCs) provide an attractive source for establishing in vitro disease models and for applications in drug screening. hiPSCs have the ability to self-renew, allowing researchers to obtain large amounts of starting material. hiPSCs also have the potential to differentiate into any cell type in the body. In this review, we discuss how the application of hiPSC technology to studying FOP has changed our perspectives on FOP disease pathogenesis. We also consider ongoing challenges and emerging opportunities for the use of human iPSCs in drug discovery and regenerative medicine. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Human-Induced Pluripotent Stem Cell Technology and Cardiomyocyte Generation: Progress and Clinical Applications.

    Science.gov (United States)

    Di Baldassarre, Angela; Cimetta, Elisa; Bollini, Sveva; Gaggi, Giulia; Ghinassi, Barbara

    2018-05-25

    Human-induced pluripotent stem cells (hiPSCs) are reprogrammed cells that have hallmarks similar to embryonic stem cells including the capacity of self-renewal and differentiation into cardiac myocytes. The improvements in reprogramming and differentiating methods achieved in the past 10 years widened the use of hiPSCs, especially in cardiac research. hiPSC-derived cardiac myocytes (CMs) recapitulate phenotypic differences caused by genetic variations, making them attractive human disease models and useful tools for drug discovery and toxicology testing. In addition, hiPSCs can be used as sources of cells for cardiac regeneration in animal models. Here, we review the advances in the genetic and epigenetic control of cardiomyogenesis that underlies the significant improvement of the induced reprogramming of somatic cells to CMs; the methods used to improve scalability of throughput assays for functional screening and drug testing in vitro; the phenotypic characteristics of hiPSCs-derived CMs and their ability to rescue injured CMs through paracrine effects; we also cover the novel approaches in tissue engineering for hiPSC-derived cardiac tissue generation, and finally, their immunological features and the potential use in biomedical applications.

  5. Graphene Sheet-Induced Global Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells.

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    Wang, Jiaxian; Cui, Chang; Nan, Haiyan; Yu, Yuanfang; Xiao, Yini; Poon, Ellen; Yang, Gang; Wang, Xijie; Wang, Chenchen; Li, Lingsong; Boheler, Kenneth Richard; Ma, Xu; Cheng, Xin; Ni, Zhenhua; Chen, Minglong

    2017-08-09

    Human induced pluripotent stem cells (hiPSCs) can proliferate infinitely. Their ability to differentiate into cardiomyocytes provides abundant sources for disease modeling, drug screening and regenerative medicine. However, hiPSC-derived cardiomyocytes (hiPSC-CMs) display a low degree of maturation and fetal-like properties. Current in vitro differentiation methods do not mimic the structural, mechanical, or physiological properties of the cardiogenesis niche. Recently, we present an efficient cardiac maturation platform that combines hiPSCs monolayer cardiac differentiation with graphene substrate, which is a biocompatible and superconductive material. The hiPSCs lines were successfully maintained on the graphene sheets and were able to differentiate into functional cardiomyocytes. This strategy markedly increased the myofibril ultrastructural organization, elevated the conduction velocity, and enhanced both the Ca 2+ handling and electrophysiological properties in the absence of electrical stimulation. On the graphene substrate, the expression of connexin 43 increased along with the conduction velocity. Interestingly, the bone morphogenetic proteins signaling was also significantly activated during early cardiogenesis, confirmed by RNA sequencing analysis. Here, we reasoned that graphene substrate as a conductive biomimetic surface could facilitate the intrinsic electrical propagation, mimicking the microenvironment of the native heart, to further promote the global maturation of hiPSC-CMs. Our findings highlight the capability of electrically active substrates to influence cardiomyocyte development. We believe that application of graphene sheets will be useful for simple, fast, and scalable maturation of regenerated cardiomyocytes.

  6. Detailed Characterization of Human Induced Pluripotent Stem Cells Manufactured for Therapeutic Applications.

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    Baghbaderani, Behnam Ahmadian; Syama, Adhikarla; Sivapatham, Renuka; Pei, Ying; Mukherjee, Odity; Fellner, Thomas; Zeng, Xianmin; Rao, Mahendra S

    2016-08-01

    We have recently described manufacturing of human induced pluripotent stem cells (iPSC) master cell banks (MCB) generated by a clinically compliant process using cord blood as a starting material (Baghbaderani et al. in Stem Cell Reports, 5(4), 647-659, 2015). In this manuscript, we describe the detailed characterization of the two iPSC clones generated using this process, including whole genome sequencing (WGS), microarray, and comparative genomic hybridization (aCGH) single nucleotide polymorphism (SNP) analysis. We compare their profiles with a proposed calibration material and with a reporter subclone and lines made by a similar process from different donors. We believe that iPSCs are likely to be used to make multiple clinical products. We further believe that the lines used as input material will be used at different sites and, given their immortal status, will be used for many years or even decades. Therefore, it will be important to develop assays to monitor the state of the cells and their drift in culture. We suggest that a detailed characterization of the initial status of the cells, a comparison with some calibration material and the development of reporter sublcones will help determine which set of tests will be most useful in monitoring the cells and establishing criteria for discarding a line.

  7. Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells

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    Bershteyn, Marina; Hayashi, Yohei; Desachy, Guillaume; Hsiao, Edward C.; Sami, Salma; Tsang, Kathryn M.; Weiss, Lauren A.; Kriegstein, Arnold R.; Yamanaka, Shinya; Wynshaw-Boris, Anthony

    2014-03-01

    Ring chromosomes are structural aberrations commonly associated with birth defects, mental disabilities and growth retardation. Rings form after fusion of the long and short arms of a chromosome, and are sometimes associated with large terminal deletions. Owing to the severity of these large aberrations that can affect multiple contiguous genes, no possible therapeutic strategies for ring chromosome disorders have been proposed. During cell division, ring chromosomes can exhibit unstable behaviour leading to continuous production of aneuploid progeny with low viability and high cellular death rate. The overall consequences of this chromosomal instability have been largely unexplored in experimental model systems. Here we generated human induced pluripotent stem cells (iPSCs) from patient fibroblasts containing ring chromosomes with large deletions and found that reprogrammed cells lost the abnormal chromosome and duplicated the wild-type homologue through the compensatory uniparental disomy (UPD) mechanism. The karyotypically normal iPSCs with isodisomy for the corrected chromosome outgrew co-existing aneuploid populations, enabling rapid and efficient isolation of patient-derived iPSCs devoid of the original chromosomal aberration. Our results suggest a fundamentally different function for cellular reprogramming as a means of `chromosome therapy' to reverse combined loss-of-function across many genes in cells with large-scale aberrations involving ring structures. In addition, our work provides an experimentally tractable human cellular system for studying mechanisms of chromosomal number control, which is of critical relevance to human development and disease.

  8. Human Induced Pluripotent Stem Cells from Basic Research to Potential Clinical Applications in Cancer

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    Teresa de Souza Fernandez

    2013-01-01

    Full Text Available The human induced pluripotent stem cells (hiPSCs are derived from a direct reprogramming of human somatic cells to a pluripotent stage through ectopic expression of specific transcription factors. These cells have two important properties, which are the self-renewal capacity and the ability to differentiate into any cell type of the human body. So, the discovery of hiPSCs opens new opportunities in biomedical sciences, since these cells may be useful for understanding the mechanisms of diseases in the production of new diseases models, in drug development/drug toxicity tests, gene therapies, and cell replacement therapies. However, the hiPSCs technology has limitations including the potential for the development of genetic and epigenetic abnormalities leading to tumorigenicity. Nowadays, basic research in the hiPSCs field has made progress in the application of new strategies with the aim to enable an efficient production of high-quality of hiPSCs for safety and efficacy, necessary to the future application for clinical practice. In this review, we show the recent advances in hiPSCs’ basic research and some potential clinical applications focusing on cancer. We also present the importance of the use of statistical methods to evaluate the possible validation for the hiPSCs for future therapeutic use toward personalized cell therapies.

  9. An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells.

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    Tcw, Julia; Wang, Minghui; Pimenova, Anna A; Bowles, Kathryn R; Hartley, Brigham J; Lacin, Emre; Machlovi, Saima I; Abdelaal, Rawan; Karch, Celeste M; Phatnani, Hemali; Slesinger, Paul A; Zhang, Bin; Goate, Alison M; Brennand, Kristen J

    2017-08-08

    Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from human induced pluripotent stem cells (hiPSCs), via a neural progenitor cell (NPC) intermediate. We evaluated this protocol across 42 NPC lines (derived from 30 individuals). Transcriptomic analysis demonstrated that hiPSC-astrocytes from four individuals are highly similar to primary human fetal astrocytes and characteristic of a non-reactive state. hiPSC-astrocytes respond to inflammatory stimulants, display phagocytic capacity, and enhance microglial phagocytosis. hiPSC-astrocytes also possess spontaneous calcium transient activity. Our protocol is a reproducible, straightforward (single medium), and rapid (method to generate populations of hiPSC-astrocytes that can be used for neuron-astrocyte and microglia-astrocyte co-cultures for the study of neuropsychiatric disorders. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  10. Directed Differentiation of Human-Induced Pluripotent Stem Cells to Mesenchymal Stem Cells.

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    Lian, Qizhou; Zhang, Yuelin; Liang, Xiaoting; Gao, Fei; Tse, Hung-Fat

    2016-01-01

    Multipotent stromal cells, also known as mesenchymal stem cells (MSCs), possess great potential to generate a wide range of cell types including endothelial cells, smooth muscle cells, bone, cartilage, and lipid cells. This protocol describes in detail how to perform highly efficient, lineage-specific differentiation of human-induced pluripotent stem cells (iPSCs) with an MSCs fate. The approach uses a clinically compliant protocol with chemically defined media, feeder-free conditions, and a CD105 positive and CD24 negative selection to achieve a single cell-based MSCs derivation from differentiating human pluripotent cells in approximately 20 days. Cells generated with this protocol express typical MSCs surface markers and undergo adipogenesis, osteogenesis, and chondrogenesis similar to adult bone marrow-derived MSCs (BM-MSCs). Nonetheless, compared with adult BM-MSCs, iPSC-MSCs display a higher proliferative capacity, up to 120 passages, without obvious loss of self-renewal potential and constitutively express MSCs surface antigens. MSCs generated with this protocol have numerous applications, including expansion to large scale cell numbers for tissue engineering and the development of cellular therapeutics. This approach has been used to rescue limb ischemia, allergic disorders, and cigarette smoke-induced lung damage and to model mesenchymal and vascular disorders of Hutchinson-Gilford progeria syndrome (HGPS).

  11. Small-Molecule Induction Promotes Corneal Epithelial Cell Differentiation from Human Induced Pluripotent Stem Cells

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    Alexandra Mikhailova

    2014-02-01

    Full Text Available Human induced pluripotent stem cells (hiPSCs offer unique opportunities for developing novel cell-based therapies and disease modeling. In this study, we developed a directed differentiation method for hiPSCs toward corneal epithelial progenitor cells capable of terminal differentiation toward mature corneal epithelial-like cells. In order to improve the efficiency and reproducibility of our method, we replicated signaling cues active during ocular surface ectoderm development with the help of two small-molecule inhibitors in combination with basic fibroblast growth factor (bFGF in serum-free and feeder-free conditions. First, small-molecule induction downregulated the expression of pluripotency markers while upregulating several transcription factors essential for normal eye development. Second, protein expression of the corneal epithelial progenitor marker p63 was greatly enhanced, with up to 95% of cells being p63 positive after 5 weeks of differentiation. Third, corneal epithelial-like cells were obtained upon further maturation.

  12. Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9.

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    Yumlu, Saniye; Stumm, Jürgen; Bashir, Sanum; Dreyer, Anne-Kathrin; Lisowski, Pawel; Danner, Eric; Kühn, Ralf

    2017-05-15

    Human induced pluripotent stem cells (hiPSCs) represent an ideal in vitro platform to study human genetics and biology. The recent advent of programmable nucleases makes also the human genome amenable to experimental genetics through either the correction of mutations in patient-derived iPSC lines or the de novo introduction of mutations into otherwise healthy iPSCs. The production of specific and sometimes complex genotypes in multiple cell lines requires efficient and streamlined gene editing technologies. In this article we provide protocols for gene editing in hiPSCs. We presently achieve high rates of gene editing at up to three loci using a modified iCRISPR system. This system includes a doxycycline inducible Cas9 and sgRNA/reporter plasmids for the enrichment of transfected cells by fluorescence-activated cell sorting (FACS). Here we cover the selection of target sites, vector construction, transfection, and isolation and genotyping of modified hiPSC clones. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Expandable and Rapidly Differentiating Human Induced Neural Stem Cell Lines for Multiple Tissue Engineering Applications

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    Dana M. Cairns

    2016-09-01

    Full Text Available Limited availability of human neurons poses a significant barrier to progress in biological and preclinical studies of the human nervous system. Current stem cell-based approaches of neuron generation are still hindered by prolonged culture requirements, protocol complexity, and variability in neuronal differentiation. Here we establish stable human induced neural stem cell (hiNSC lines through the direct reprogramming of neonatal fibroblasts and adult adipose-derived stem cells. These hiNSCs can be passaged indefinitely and cryopreserved as colonies. Independently of media composition, hiNSCs robustly differentiate into TUJ1-positive neurons within 4 days, making them ideal for innervated co-cultures. In vivo, hiNSCs migrate, engraft, and contribute to both central and peripheral nervous systems. Lastly, we demonstrate utility of hiNSCs in a 3D human brain model. This method provides a valuable interdisciplinary tool that could be used to develop drug screening applications as well as patient-specific disease models related to disorders of innervation and the brain.

  14. Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells

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    Qiang Feng

    2014-11-01

    Full Text Available Human induced pluripotent stem cells (iPSCs provide a potentially replenishable source for the production of transfusable platelets. Here, we describe a method to generate megakaryocytes (MKs and functional platelets from iPSCs in a scalable manner under serum/feeder-free conditions. The method also permits the cryopreservation of MK progenitors, enabling a rapid “surge” capacity when large numbers of platelets are needed. Ultrastructural/morphological analyses show no major differences between iPSC platelets and human blood platelets. iPSC platelets form aggregates, lamellipodia, and filopodia after activation and circulate in macrophage-depleted animals and incorporate into developing mouse thrombi in a manner identical to human platelets. By knocking out the β2-microglobulin gene, we have generated platelets that are negative for the major histocompatibility antigens. The scalable generation of HLA-ABC-negative platelets from a renewable cell source represents an important step toward generating universal platelets for transfusion as well as a potential strategy for the management of platelet refractoriness.

  15. Tributyltin induces mitochondrial fission through Mfn1 degradation in human induced pluripotent stem cells.

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    Yamada, Shigeru; Asanagi, Miki; Hirata, Naoya; Itagaki, Hiroshi; Sekino, Yuko; Kanda, Yasunari

    2016-08-01

    Organotin compounds, such as tributyltin (TBT), are well-known endocrine disruptors. TBT is also known to cause various forms of cytotoxicity, including neurotoxicity and immunotoxicity. However, TBT toxicity has not been identified in normal stem cells. In the present study, we examined the effects of TBT on cell growth in human induced pluripotent stem cells (iPSCs). We found that exposure to nanomolar concentrations of TBT decreased intracellular ATP levels and inhibited cell viability in iPSCs. Because TBT suppressed energy production, which is a critical function of the mitochondria, we further assessed the effects of TBT on mitochondrial dynamics. Staining with MitoTracker revealed that nanomolar concentrations of TBT induced mitochondrial fragmentation. TBT also reduced the expression of mitochondrial fusion protein mitofusin 1 (Mfn1), and this effect was abolished by knockdown of the E3 ubiquitin ligase membrane-associated RING-CH 5 (MARCH5), suggesting that nanomolar concentrations of TBT could induce mitochondrial dysfunction via MARCH5-mediated Mfn1 degradation in iPSCs. Thus, mitochondrial function in normal stem cells could be used to assess cytotoxicity associated with metal exposure. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Scalable topographies to support proliferation and Oct4 expression by human induced pluripotent stem cells.

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    Reimer, Andreas; Vasilevich, Aliaksei; Hulshof, Frits; Viswanathan, Priyalakshmi; van Blitterswijk, Clemens A; de Boer, Jan; Watt, Fiona M

    2016-01-13

    It is well established that topographical features modulate cell behaviour, including cell morphology, proliferation and differentiation. To define the effects of topography on human induced pluripotent stem cells (iPSC), we plated cells on a topographical library containing over 1000 different features in medium lacking animal products (xeno-free). Using high content imaging, we determined the effect of each topography on cell proliferation and expression of the pluripotency marker Oct4 24 h after seeding. Features that maintained Oct4 expression also supported proliferation and cell-cell adhesion at 24 h, and by 4 days colonies of Oct4-positive, Sox2-positive cells had formed. Computational analysis revealed that small feature size was the most important determinant of pluripotency, followed by high wave number and high feature density. Using this information we correctly predicted whether any given topography within our library would support the pluripotent state at 24 h. This approach not only facilitates the design of substrates for optimal human iPSC expansion, but also, potentially, identification of topographies with other desirable characteristics, such as promoting differentiation.

  17. Microfluidic perfusion culture of human induced pluripotent stem cells under fully defined culture conditions.

    Science.gov (United States)

    Yoshimitsu, Ryosuke; Hattori, Koji; Sugiura, Shinji; Kondo, Yuki; Yamada, Rotaro; Tachikawa, Saoko; Satoh, Taku; Kurisaki, Akira; Ohnuma, Kiyoshi; Asashima, Makoto; Kanamori, Toshiyuki

    2014-05-01

    Human induced pluripotent stem cells (hiPSCs) are a promising cell source for drug screening. For this application, self-renewal or differentiation of the cells is required, and undefined factors in the culture conditions are not desirable. Microfluidic perfusion culture allows the production of small volume cultures with precisely controlled microenvironments, and is applicable to high-throughput cellular environment screening. Here, we developed a microfluidic perfusion culture system for hiPSCs that uses a microchamber array chip under defined extracellular matrix (ECM) and culture medium conditions. By screening various ECMs we determined that fibronectin and laminin are appropriate for microfluidic devices made out of the most popular material, polydimethylsiloxane (PDMS). We found that the growth rate of hiPSCs under pressure-driven perfusion culture conditions was higher than under static culture conditions in the microchamber array. We applied our new system to self-renewal and differentiation cultures of hiPSCs, and immunocytochemical analysis showed that the state of the hiPSCs was successfully controlled. The effects of three antitumor drugs on hiPSCs were comparable between microchamber array and 96-well plates. We believe that our system will be a platform technology for future large-scale screening of fully defined conditions for differentiation cultures on integrated microfluidic devices. © 2013 Wiley Periodicals, Inc.

  18. Human Induced Pluripotent Stem Cell-Derived Macrophages for Unraveling Human Macrophage Biology.

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    Zhang, Hanrui; Reilly, Muredach P

    2017-11-01

    Despite a substantial appreciation for the critical role of macrophages in cardiometabolic diseases, understanding of human macrophage biology has been hampered by the lack of reliable and scalable models for cellular and genetic studies. Human induced pluripotent stem cell (iPSC)-derived macrophages (IPSDM), as an unlimited source of subject genotype-specific cells, will undoubtedly play an important role in advancing our understanding of the role of macrophages in human diseases. In this review, we summarize current literature in the differentiation and characterization of IPSDM at phenotypic, functional, and transcriptomic levels. We emphasize the progress in differentiating iPSC to tissue resident macrophages, and in understanding the ontogeny of in vitro differentiated IPSDM that resembles primitive hematopoiesis, rather than adult definitive hematopoiesis. We review the application of IPSDM in modeling both Mendelian genetic disorders and host-pathogen interactions. Finally, we highlighted the potential areas of research using IPSDM in functional validation of coronary artery disease loci in genome-wide association studies, functional genomic analyses, drug testing, and cell therapeutics in cardiovascular diseases. © 2017 American Heart Association, Inc.

  19. A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids

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    Yu Takahashi

    2018-01-01

    Full Text Available Gut epithelial organoids are routinely used to investigate intestinal biology; however, current culture methods are not amenable to genetic manipulation, and it is difficult to generate sufficient numbers for high-throughput studies. Here, we present an improved culture system of human induced pluripotent stem cell (iPSC-derived intestinal organoids involving four methodological advances. (1 We adopted a lentiviral vector to readily establish and optimize conditioned medium for human intestinal organoid culture. (2 We obtained intestinal organoids from human iPSCs more efficiently by supplementing WNT3A and fibroblast growth factor 2 to induce differentiation into definitive endoderm. (3 Using 2D culture, followed by re-establishment of organoids, we achieved an efficient transduction of exogenous genes in organoids. (4 We investigated suspension organoid culture without scaffolds for easier harvesting and assays. These techniques enable us to develop, maintain, and expand intestinal organoids readily and quickly at low cost, facilitating high-throughput screening of pathogenic factors and candidate treatments for gastrointestinal diseases.

  20. Promise and Capability of NASA's Earth Observing System to Monitor Human-Induced Climate Variations

    Science.gov (United States)

    King, M. D.

    2003-01-01

    The Earth Observing System (EOS) is a space-based observing system comprised of a series of satellite sensors by which scientists can monitor the Earth, a Data and Information System (EOSDIS) enabling researchers worldwide to access the satellite data, and an interdisciplinary science research program to interpret the satellite data. The Moderate Resolution Imaging Spectroradiometer (MODIS), developed as part of the Earth Observing System (EOS) and launched on Terra in December 1999 and Aqua in May 2002, is designed to meet the scientific needs for satellite remote sensing of clouds, aerosols, water vapor, and land and ocean surface properties. This sensor and multi-platform observing system is especially well suited to observing detailed interdisciplinary components of the Earth s surface and atmosphere in and around urban environments, including aerosol optical properties, cloud optical and microphysical properties of both liquid water and ice clouds, land surface reflectance, fire occurrence, and many other properties that influence the urban environment and are influenced by them. In this presentation I will summarize the current capabilities of MODIS and other EOS sensors currently in orbit to study human-induced climate variations.

  1. The human-induced pluripotent stem cell initiative—data resources for cellular genetics

    Science.gov (United States)

    Streeter, Ian; Harrison, Peter W.; Faulconbridge, Adam; Flicek, Paul; Parkinson, Helen; Clarke, Laura

    2017-01-01

    The Human Induced Pluripotent Stem Cell Initiative (HipSci) isf establishing a large catalogue of human iPSC lines, arguably the most well characterized collection to date. The HipSci portal enables researchers to choose the right cell line for their experiment, and makes HipSci's rich catalogue of assay data easy to discover and reuse. Each cell line has genomic, transcriptomic, proteomic and cellular phenotyping data. Data are deposited in the appropriate EMBL-EBI archives, including the European Nucleotide Archive (ENA), European Genome-phenome Archive (EGA), ArrayExpress and PRoteomics IDEntifications (PRIDE) databases. The project will make 500 cell lines from healthy individuals, and from 150 patients with rare genetic diseases; these will be available through the European Collection of Authenticated Cell Cultures (ECACC). As of August 2016, 238 cell lines are available for purchase. Project data is presented through the HipSci data portal (http://www.hipsci.org/lines) and is downloadable from the associated FTP site (ftp://ftp.hipsci.ebi.ac.uk/vol1/ftp). The data portal presents a summary matrix of the HipSci cell lines, showing available data types. Each line has its own page containing descriptive metadata, quality information, and links to archived assay data. Analysis results are also available in a Track Hub, allowing visualization in the context of public genomic annotations (http://www.hipsci.org/data/trackhubs). PMID:27733501

  2. The human-induced pluripotent stem cell initiative-data resources for cellular genetics.

    Science.gov (United States)

    Streeter, Ian; Harrison, Peter W; Faulconbridge, Adam; Flicek, Paul; Parkinson, Helen; Clarke, Laura

    2017-01-04

    The Human Induced Pluripotent Stem Cell Initiative (HipSci) isf establishing a large catalogue of human iPSC lines, arguably the most well characterized collection to date. The HipSci portal enables researchers to choose the right cell line for their experiment, and makes HipSci's rich catalogue of assay data easy to discover and reuse. Each cell line has genomic, transcriptomic, proteomic and cellular phenotyping data. Data are deposited in the appropriate EMBL-EBI archives, including the European Nucleotide Archive (ENA), European Genome-phenome Archive (EGA), ArrayExpress and PRoteomics IDEntifications (PRIDE) databases. The project will make 500 cell lines from healthy individuals, and from 150 patients with rare genetic diseases; these will be available through the European Collection of Authenticated Cell Cultures (ECACC). As of August 2016, 238 cell lines are available for purchase. Project data is presented through the HipSci data portal (http://www.hipsci.org/lines) and is downloadable from the associated FTP site (ftp://ftp.hipsci.ebi.ac.uk/vol1/ftp). The data portal presents a summary matrix of the HipSci cell lines, showing available data types. Each line has its own page containing descriptive metadata, quality information, and links to archived assay data. Analysis results are also available in a Track Hub, allowing visualization in the context of public genomic annotations (http://www.hipsci.org/data/trackhubs). © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  3. Synchrony in hunting bags: reaction on climatic and human induced changes?

    Science.gov (United States)

    Hagen, Robert; Heurich, Marco; Kröschel, Max; Herdtfelder, Micha

    2014-01-15

    Human induced land use changes negatively impact the viability of many wildlife species through habitat modifications and mortality, while some species seem to benefit from it. Roe deer (Capreolus capreolus), a wide spread ungulate increased both its abundance and range throughout Europe. This pattern is also reflected in the increasing hunting bags over the last 40 years. Such a development raises questions about the relationship between human hunting and population dynamics and, in particular, about the potential of human hunting to control related populations. We analysed and reconstructed annual hunting bags of roe deer for three federal states of northern Germany, Brandenburg, Lower Saxony and Mecklenburg West Pomerania for the years 1972 to 2011. Since 1992 the hunting bags from these three states are significantly higher than those reported for the years 1972-1991. Our reconstruction takes into consideration effects of climate variability, expressed by inter-annual changes in the North Atlantic Oscillation and impacts from rapeseed and wheat cultivation. We found that severe winters, which are indicated by negative values of the North Atlantic Oscillation during the months December-March, directly, or with a time lag of two years affect the number of deer shot. In contrast, an increase in the area used for rapeseed cultivation coincides with higher numbers of roe deer shot, with respect to the overall mean value. Consequently, we recommend that wildlife management addresses changes in large scale processes including land use pattern and climate variability. © 2013.

  4. Observing Human-induced Linkages between Urbanization and Earth's Climate System

    Science.gov (United States)

    Shepherd, J. Marshall; Jin, Menglin

    2004-01-01

    Urbanization is one of the extreme cases of land use change. Most of world s population has moved to urban areas. Although currently only 1.2% of the land is considered urban, the spatial coverage and density of cities are expected to rapidly increase in the near future. It is estimated that by the year 2025, 60% of the world s population will live in cities. Human activity in urban environments also alters atmospheric composition; impacts components of the water cycle; and modifies the carbon cycle and ecosystems. However, our understanding of urbanization on the total Earth-climate system is incomplete. Better understanding of how the Earth s atmosphere-ocean-land-biosphere components interact as a coupled system and the influence of the urban environment on this climate system is critical. The goal of the 2003 AGU Union session Human-induced climate variations on urban areas: From observations to modeling was to bring together scientists from interdisciplinary backgrounds to discuss the data, scientific approaches and recent results on observing and modeling components of the urban environment with the intent of sampling our current stand and discussing future direction on this topic. Herein, a summary and discussion of the observations component of the session are presented.

  5. Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Faye M. Drawnel

    2014-11-01

    Full Text Available Diabetic cardiomyopathy is a complication of type 2 diabetes, with known contributions of lifestyle and genetics. We develop environmentally and genetically driven in vitro models of the condition using human-induced-pluripotent-stem-cell-derived cardiomyocytes. First, we mimic diabetic clinical chemistry to induce a phenotypic surrogate of diabetic cardiomyopathy, observing structural and functional disarray. Next, we consider genetic effects by deriving cardiomyocytes from two diabetic patients with variable disease progression. The cardiomyopathic phenotype is recapitulated in the patient-specific cells basally, with a severity dependent on their original clinical status. These models are incorporated into successive levels of a screening platform, identifying drugs that preserve cardiomyocyte phenotype in vitro during diabetic stress. In this work, we present a patient-specific induced pluripotent stem cell (iPSC model of a complex metabolic condition, showing the power of this technique for discovery and testing of therapeutic strategies for a disease with ever-increasing clinical significance.

  6. Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells.

    Directory of Open Access Journals (Sweden)

    Leonardo D'Aiuto

    Full Text Available Human cytomegalovirus (HCMV infection is one of the leading prenatal causes of congenital mental retardation and deformities world-wide. Access to cultured human neuronal lineages, necessary to understand the species specific pathogenic effects of HCMV, has been limited by difficulties in sustaining primary human neuronal cultures. Human induced pluripotent stem (iPS cells now provide an opportunity for such research. We derived iPS cells from human adult fibroblasts and induced neural lineages to investigate their susceptibility to infection with HCMV strain Ad169. Analysis of iPS cells, iPS-derived neural stem cells (NSCs, neural progenitor cells (NPCs and neurons suggests that (i iPS cells are not permissive to HCMV infection, i.e., they do not permit a full viral replication cycle; (ii Neural stem cells have impaired differentiation when infected by HCMV; (iii NPCs are fully permissive for HCMV infection; altered expression of genes related to neural metabolism or neuronal differentiation is also observed; (iv most iPS-derived neurons are not permissive to HCMV infection; and (v infected neurons have impaired calcium influx in response to glutamate.

  7. Noise in the operating room

    DEFF Research Database (Denmark)

    Hasfeldt-Hansen, Dorthe; Lærkner, Eva Ann; Birkelund, Regner

    2010-01-01

    Because noise is a general stressor, noise in the OR should be avoided whenever possible. This article presents the results of a review of the research literature on the topic of noise in the OR. A systematic literature search was conducted. Eighteen relevant articles were identified...... and categorized as follows: noise levels, noise sources, staff performances, and patient’s perception of noise. Each study was assessed according to the strength of the evidence and the quality of the study. Noise levels in the OR in general exceed recommended levels, and the noise sources are related...... to equipment and staff behavior. The main effect of noise on staff performances is related to impaired communication, resulting in a negative effect on patient safety. The literature on patients’ perception of noise is both limited and inconsistent, and more research on this topic is needed....

  8. RADIO VARIABILITY IN SEYFERT NUCLEI

    International Nuclear Information System (INIS)

    Mundell, C. G.; Ferruit, P.; Nagar, N.; Wilson, A. S.

    2009-01-01

    Comparison of 8.4 GHz radio images of a sample of eleven, early-type Seyfert galaxies with previous observations reveals possible variation in the nuclear radio flux density in five of them over a seven year period. Four Seyferts (NGC 2110, NGC 3081, MCG -6-30-15, and NGC 5273) show a decline in their 8.4 GHz nuclear flux density between 1992 and 1999, while one (NGC 4117) shows an increase; the flux densities of the remaining six Seyferts (Mrk 607, NGC 1386, Mrk 620, NGC 3516, NGC 4968, and NGC 7465) have remained constant over this period. New images of MCG -5-23-16 are also presented. We find no correlation between radio variability and nuclear radio luminosity or Seyfert nuclear type, although the sample is small and dominated by type 2 Seyferts. Instead, a possible correlation between the presence of nuclear radio variability and the absence of hundred parsec-scale radio emission is seen, with four out of five marginally resolved or unresolved nuclei showing a change in nuclear flux density, while five out of six extended sources show no nuclear variability despite having unresolved nuclear sources. NGC 2110 is the only source in our sample with significant extended radio structure and strong nuclear variability (∼38% decline in nuclear flux density over seven years). The observed nuclear flux variability indicates significant changes are likely to have occurred in the structure of the nucleus on scales smaller than the VLA beam size (i.e., within the central ∼0.''1 (15 pc)), between the two epochs, possibly due to the appearance and fading of new components or shocks in the jet, consistent with previous detection of subparsec-scale nuclear structure in this Seyfert. Our results suggest that all Seyferts may exhibit variation in their nuclear radio flux density at 8.4 GHz, but that variability is more easily recognized in compact sources in which emission from the variable nucleus is not diluted by unresolved, constant flux density radio jet emission

  9. Radio science investigations with Voyager

    International Nuclear Information System (INIS)

    Eshleman, V.R.; Tyler, G.L.; Croft, T.A.

    1977-01-01

    The planned radio science investigations during the Voyager missions to the outer planets involve: (1) the use of the radio links to and from the spacecraft for occultation measurements of planetary and satellite atmospheres and ionospheres, the rings of Saturn, the solar corona, and the general-relativistic time delay for radiowave propagation through the Sun's gravity field; (2) radio link measurements of true or apparent spacecraft motion caused by the gravity fields of the planets, the masses of their larger satellites, and characteristics of the interplanetary medium; and (3) related measurements which could provide results in other areas, including the possible detection of long-wavelength gravitational radiation propagating through the Solar System. The measurements will be used to study: atmospheric and ionospheric structure, constituents, and dynamics; the sizes, radial distribution, total mass, and other characteristics of the particles in the rings of Saturn; interior models for the major planets and the mean density and bulk composition of a number of their satellites; the plasma density and dynamics of the solar corona and interplanetary medium; and certain fundamental questions involving gravitation and relativity. The instrumentation for these experiments is the same ground-based and spacecraft radio systems as will be used for tracking and communicating with the Voyager spacecraft, although several important features of these systems have been provided primarily for the radio science investigations. (Auth.)

  10. Observations of radio sources or 'What happened to radio stars?'

    International Nuclear Information System (INIS)

    Conway, R.G.

    1988-01-01

    A review is given of the early history of the interpretation of the radiation mechanisms following the discovery of the discrete radio sources, both galactic and extragalactic. The conflicting views which prevailed in the early fifties are discussed in some detail: some advocated thermal radiation from stars relatively close by, and others proposed the alternative that synchrotron radiation was responsible for the majority of the radio sources. Attention is drawn to the importance of high-resolution interferometry, whereby the structure of many of the sources could be obtained. Red-shift measurements and spectral distributions also played a part in determining distances and flux strengths at the sources. (U.K.)

  11. A molecular noise generator

    International Nuclear Information System (INIS)

    Lu Ting; Ferry, Michael; Hasty, Jeff; Weiss, Ron

    2008-01-01

    Recent studies have demonstrated that intracellular variations in the rate of gene expression are of fundamental importance to cellular function and development. While such 'noise' is often considered detrimental in the context of perturbing genetic systems, it can be beneficial in processes such as species diversification and facilitation of evolution. A major difficulty in exploring such effects is that the magnitude and spectral properties of the induced variations arise from some intrinsic cellular process that is difficult to manipulate. Here, we present two designs of a molecular noise generator that allow for the flexible modulation of the noise profile of a target gene. The first design uses a dual-signal mechanism that enables independent tuning of the mean and variability of an output protein. This is achieved through the combinatorial control of two signals that regulate transcription and translation separately. We then extend the design to allow for DNA copy-number regulation, which leads to a wider tuning spectrum for the output molecule. To gain a deeper understanding of the circuit's functionality in a realistic environment, we introduce variability in the input signals in order to ascertain the degree of noise induced by the control process itself. We conclude by illustrating potential applications of the noise generator, demonstrating how it could be used to ascertain the robust or fragile properties of a genetic circuit

  12. Power reactor noise

    International Nuclear Information System (INIS)

    Thie, J.A.

    1981-01-01

    Noise analysis is a growing field that offers advantages such as simplicity, low cost, and natural multivariable interactions. A major advantage, continuous and undisturbed monitoring, supplies a means of obtaining early warnings of possible reactor malfunctions, thus preventing further complications by alerting opeators to a problem - and aiding in the diagnosis of that problem - before it demands major repairs. Dr. Thie hopes to further, through detailed explanations and over 70 illustrations, the acceptance of the use of noise analysis by the nuclear utility industry. Following an introductory chapter, the theoretical basis for the various methods of noise analysis is explained, and full chapters are devoted to the fundamentals of statistics for time-domain analysis and Fourier series and related topics for frequency-domain analysis. General experimental techniques and associated theoretical considerations are reviewed, leading to discussions of practical applications in the latter half of the book. Besides chapters giving examples of neutron noise and acoustical noise, chapters are also devoted to extensive examples from pressurized water reactor and boiling water reactor power plants

  13. RF Shot Noise Measurements in Au Atomic-scale Junctions

    Science.gov (United States)

    Chen, Ruoyu

    Conduction electrons are responsible for many physical or chemical phenomena in condensed matter systems, and their behavior can be directly studied by electronic transport measurements. In conventional transport measurements, conductance or resistance is usually the focus. Such a measurement can be as simple as a quick two terminal DC check by a multi-meter, or a more sophisticated lock-in measurement of multiple higher harmonic signals synchronized to different frequencies. Conductance carries direct information about the quasi-particle density of states and the local electronic distributions, which are usually Fermi-Dirac distribution. Conductance is modified or dominated by scattering from defacts or interfaces, and could also reflect the spin-spin exchange interactions or inelastic couplings with phonons and photons. Naturally one can ask the question: is there anything else we can measure electronically, which carries extra information that a conductance measurement does not provide? One answer to this question is the electronic noise. While the conductance reflects the average charge conduction ability of a system, noise describes how the physical quantities fluctuate around their average values. Some of the fluctuations carry information about their physical origins. This thesis will focus on one particular type of the electronic noise shot noise, but other types of noise will also be introduced and discussed. We choose to measure the radio frequency component of shot noise, combining with a modulated lock-in detection technique, which provides a method to largely get rid of other unwanted low-frequency noise signals. Au atomic-scale junctions are the systems we studied here. Au is relatively well understood and will not generate too many complications, so it's ideal as the first platform for us to understand both shot noise itself and our RF technique. On the other hand, the atomic scale raises fundamental questions about electronic transport and local

  14. Radio Context Awareness and Applications

    Directory of Open Access Journals (Sweden)

    Luca Reggiani

    2013-01-01

    Full Text Available The context refers to “any information that can be used to characterize the situation of an entity, where an entity can be a person, place, or physical object.” Radio context awareness is defined as the ability of detecting and estimating a system state or parameter, either globally or concerning one of its components, in a radio system for enhancing performance at the physical, network, or application layers. In this paper, we review the fundamentals of context awareness and the recent advances in the main radio techniques that increase the context awareness and smartness, posing challenges and renewed opportunities to added-value applications in the context of the next generation of wireless networks.

  15. Modular Software-Defined Radio

    Directory of Open Access Journals (Sweden)

    Rhiemeier Arnd-Ragnar

    2005-01-01

    Full Text Available In view of the technical and commercial boundary conditions for software-defined radio (SDR, it is suggestive to reconsider the concept anew from an unconventional point of view. The organizational principles of signal processing (rather than the signal processing algorithms themselves are the main focus of this work on modular software-defined radio. Modularity and flexibility are just two key characteristics of the SDR environment which extend smoothly into the modeling of hardware and software. In particular, the proposed model of signal processing software includes irregular, connected, directed, acyclic graphs with random node weights and random edges. Several approaches for mapping such software to a given hardware are discussed. Taking into account previous findings as well as new results from system simulations presented here, the paper finally concludes with the utility of pipelining as a general design guideline for modular software-defined radio.

  16. ECG De-noising

    DEFF Research Database (Denmark)

    Kærgaard, Kevin; Jensen, Søren Hjøllund; Puthusserypady, Sadasivan

    2015-01-01

    Electrocardiogram (ECG) is a widely used noninvasive method to study the rhythmic activity of the heart and thereby to detect the abnormalities. However, these signals are often obscured by artifacts from various sources and minimization of these artifacts are of paramount important. This paper...... proposes two adaptive techniques, namely the EEMD-BLMS (Ensemble Empirical Mode Decomposition in conjunction with the Block Least Mean Square algorithm) and DWT-NN (Discrete Wavelet Transform followed by Neural Network) methods in minimizing the artifacts from recorded ECG signals, and compares...... their performance. These methods were first compared on two types of simulated noise corrupted ECG signals: Type-I (desired ECG+noise frequencies outside the ECG frequency band) and Type-II (ECG+noise frequencies both inside and outside the ECG frequency band). Subsequently, they were tested on real ECG recordings...

  17. Joyce’s Noises

    Directory of Open Access Journals (Sweden)

    Derek Attridge

    2009-10-01

    Full Text Available James Joyce uses both lexical and nonlexical onomatopoeia extensively in _Ulysses_; this essay examines some of the ways in which he employs the latter in order to convey noises of many kinds. Nonlexical onomatopoeia is particularly suited to the evocation of noise, though it can only do so in conjunction with shared literary and linguistic conventions. Several of the characters in _Ulysses_ show an interest in the representation of noise in language, but there are many more examples where there is no evidence of mental processes at work. The reader’s pleasure in Joyce’s nonlexical onomatopoeia is very seldom the result of vivid imitation; it is, as these examples testify, Joyce’s play with the workings of the device (and frequently its failure to imitate the nonlinguistic world that provides enjoyment and some insight into the relation between language and sound.

  18. Noise and Tinnitus

    Directory of Open Access Journals (Sweden)

    Mansoureh Adel Ghahraman

    1999-03-01

    Full Text Available Tinnitus from the Latin word tinnire meaning ringing is the perception of sound within the human ear in the absence of corresponding external sound. The most common cause is noise induced hearing loss. Tinnitus may be induced by an acoustic trauma or a permanent noise in the workplace. In case that Tinnitus is induced by acoustic trauma the site of lesion is commonly the base of the cochlea. Tinnitus in the senile population is mostly accompanying presbycusis. Although the incidence of permanent tinnitus following noise exposure is high, little is published about this issue. In the current article we are aimed at studying the prevalence of tinnitus in Minoo and other manufactures.

  19. Wideband Balun-LNA with Simultaneous Output Balancing, Noise-Canceling and Distortion-Canceling

    NARCIS (Netherlands)

    Blaakmeer, S.C.; Klumperink, Eric A.M.; Leenaerts, D.M.W.; Nauta, Bram

    2008-01-01

    An inductorless low-noise amplifier (LNA) with active balun is proposed for multi-standard radio applications between 100 MHz and 6 GHz. It exploits a combination of a common-gate (CGH) stage and an admittance-scaled common-source (CS) stage with replica biasing to maximize balanced operation, while

  20. Wide-band residual phase-noise measurements on 40-GHz monolithic mode-locked lasers

    DEFF Research Database (Denmark)

    Larsson, David; Hvam, Jørn Märcher

    2005-01-01

    We have performed wide-band residual phase-noise measurements on semiconductor 40-GHz mode-locked lasers by employing electrical waveguide components for the radio-frequency circuit. The intrinsic timing jitters of lasers with one, two, and three quantum wells (QW) are compared and our design......-QW laser. There is good agreement between the measured results and existing theory....

  1. Unseen cosmos the universe in radio

    CERN Document Server

    Graham-Smith, Francis

    2013-01-01

    Radio telescopes have transformed our understanding of the Universe. Pulsars, quasars, Big Bang cosmology: all are discoveries of the new science of radio astronomy. Here, Francis Graham-Smith describes the birth, development, and maturity of radio astronomy, from the first discovery of cosmic radio waves to its present role as a major part of modern astronomy. Radio is part of the electromagnetic spectrum, covering infra-red, visible light, ultraviolet, X-rays, and gamma-rays, and Graham-Smith explains why it is that radio waves give us a unique view of the Universe. Tracing the development o

  2. Reconfigurable radio systems network architectures and standards

    CERN Document Server

    Iacobucci, Maria Stella

    2013-01-01

    This timely book provides a standards-based view of the development, evolution, techniques and potential future scenarios for the deployment of reconfigurable radio systems.  After an introduction to radiomobile and radio systems deployed in the access network, the book describes cognitive radio concepts and capabilities, which are the basis for reconfigurable radio systems.  The self-organizing network features introduced in 3GPP standards are discussed and IEEE 802.22, the first standard based on cognitive radio, is described. Then the ETSI reconfigurable radio systems functional ar

  3. The Analysis of Closed-form Solution for Energy Detector Dynamic Threshold Adaptation in Cognitive Radio

    Directory of Open Access Journals (Sweden)

    R. Bozovic

    2017-12-01

    Full Text Available Spectrum sensing is the most important process in cognitive radio in order to ensure interference avoidance to primary users. For optimal performance of cognitive radio, it is substantial to monitor and promptly react to dynamic changes in its operating environment. In this paper, energy detector based spectrum sensing is considered. Under the assumption that detected signal can be modelled according to an autoregressive model, noise variance is estimated from that noisy signal, as well as primary user signal power. A closed-form solution for optimal decision threshold in dynamic electromagnetic environment is proposed and analyzed.

  4. MMSE-based algorithm for joint signal detection, channel and noise variance estimation for OFDM systems

    CERN Document Server

    Savaux, Vincent

    2014-01-01

    This book presents an algorithm for the detection of an orthogonal frequency division multiplexing (OFDM) signal in a cognitive radio context by means of a joint and iterative channel and noise estimation technique. Based on the minimum mean square criterion, it performs an accurate detection of a user in a frequency band, by achieving a quasi-optimal channel and noise variance estimation if the signal is present, and by estimating the noise level in the band if the signal is absent. Organized into three chapters, the first chapter provides the background against which the system model is pr

  5. Miniature EVA Software Defined Radio

    Science.gov (United States)

    Pozhidaev, Aleksey

    2012-01-01

    As NASA embarks upon developing the Next-Generation Extra Vehicular Activity (EVA) Radio for deep space exploration, the demands on EVA battery life will substantially increase. The number of modes and frequency bands required will continue to grow in order to enable efficient and complex multi-mode operations including communications, navigation, and tracking applications. Whether conducting astronaut excursions, communicating to soldiers, or first responders responding to emergency hazards, NASA has developed an innovative, affordable, miniaturized, power-efficient software defined radio that offers unprecedented power-efficient flexibility. This lightweight, programmable, S-band, multi-service, frequency- agile EVA software defined radio (SDR) supports data, telemetry, voice, and both standard and high-definition video. Features include a modular design, an easily scalable architecture, and the EVA SDR allows for both stationary and mobile battery powered handheld operations. Currently, the radio is equipped with an S-band RF section. However, its scalable architecture can accommodate multiple RF sections simultaneously to cover multiple frequency bands. The EVA SDR also supports multiple network protocols. It currently implements a Hybrid Mesh Network based on the 802.11s open standard protocol. The radio targets RF channel data rates up to 20 Mbps and can be equipped with a real-time operating system (RTOS) that can be switched off for power-aware applications. The EVA SDR's modular design permits implementation of the same hardware at all Network Nodes concept. This approach assures the portability of the same software into any radio in the system. It also brings several benefits to the entire system including reducing system maintenance, system complexity, and development cost.

  6. Decentralized SINR Balancing in Cognitive Radio Networks

    KAUST Repository

    Dhifallah, Oussama Najeeb

    2016-07-07

    This paper considers the downlink of a cognitive radio (CR) network formed by multiple primary and secondary transmitters, where each multi-antenna transmitter serves a pre-known set of single-antenna users. The paper assumes that the secondary and primary transmitters can transmit simultaneously their data over the same frequency bands, so as to achieve a high system spectrum efficiency. The paper considers the downlink balancing problem of maximizing the minimum signal-to-interference-plus noise ratio (SINR) of the secondary transmitters subject to both total power constraint of the secondary transmitters, and maximum interference constraint at each primary user due to secondary transmissions. The paper proposes solving the problem using the alternating direction method of multipliers (ADMM), which leads to a distributed implementation through limited information exchange across the coupled secondary transmitters. The paper additionally proposes a solution that guarantees feasibility at each iteration. Simulation results demonstrate that the proposed solution converges to the centralized solution in a reasonable number of iterations.

  7. Radio-opaque dental compositions

    International Nuclear Information System (INIS)

    Temin, S.C.

    1979-01-01

    Thorium oxide or tantalum oxide, or combinations thereof are used as the x-ray material for radio-opaque filler compositions having particular applicability in dental restorative compositions. The filler compositions contain from about 3% by weight to about 10% by weight, based on the total filler composition, of the x-ray absorbing materials and the remainder being conventional particulate glass or silica, quarts or ceramic filler material. The radio opaque filler compositions are insoluble and non-leachable in alkaline, acidic or neutral aqueous environments, are essentially non-toxic, are either essentially colorless or translucent, and are compatible with acrylic monomers and other polymerizable binder systems

  8. New discoveries with radio telescopes

    International Nuclear Information System (INIS)

    Schmidt, J.

    1985-01-01

    The author describes in a simple fashion the results obtained by astronomers from ETH Zurich using the broadband 7-m radio telescope in Switzerland to observe the sun over a period of six years. He explains the results in terms of our present understanding of the sun's workings. The astronomers found that a solar eruption is not a single event but consists of tens of thousands of small eruptions or spikes each only 200 km high and producing a burst of radio waves 10-100 times as intense as the background. (T.J.R.A.)

  9. Intelligent Cognitive Radio Models for Enhancing Future Radio Astronomy Observations

    Directory of Open Access Journals (Sweden)

    Ayodele Abiola Periola

    2016-01-01

    Full Text Available Radio astronomy organisations desire to optimise the terrestrial radio astronomy observations by mitigating against interference and enhancing angular resolution. Ground telescopes (GTs experience interference from intersatellite links (ISLs. Astronomy source radio signals received by GTs are analysed at the high performance computing (HPC infrastructure. Furthermore, observation limitation conditions prevent GTs from conducting radio astronomy observations all the time, thereby causing low HPC utilisation. This paper proposes mechanisms that protect GTs from ISL interference without permanent prevention of ISL data transmission and enhance angular resolution. The ISL transmits data by taking advantage of similarities in the sequence of observed astronomy sources to increase ISL connection duration. In addition, the paper proposes a mechanism that enhances angular resolution by using reconfigurable earth stations. Furthermore, the paper presents the opportunistic computing scheme (OCS to enhance HPC utilisation. OCS enables the underutilised HPC to be used to train learning algorithms of a cognitive base station. The performances of the three mechanisms are evaluated. Simulations show that the proposed mechanisms protect GTs from ISL interference, enhance angular resolution, and improve HPC utilisation.

  10. Meteoric 10Be as a tool to investigate human induced soil fluxes: a conceptual model

    Science.gov (United States)

    Campforts, Benjamin; Govers, Gerard; Vanacker, Veerle; De Vente, Joris; Boix-Fayos, Carolina; Minella, Jean; Baken, Stijn; Smolders, Erik

    2014-05-01

    The use of meteoric 10Be as a tool to understand long term landscape behavior is becoming increasingly popular. Due its high residence time, meteoric 10Be allows in principle to investigate in situ erosion rates over time scales exceeding the period studied with classical approaches such as 137Cs. The use of meteoric 10Be strongly contributes to the traditional interpretation of sedimentary archives which cannot be unequivocally coupled to sediment production and could provide biased information over longer time scales (Sadler, 1981). So far, meteoric 10Be has successfully been used in geochemical fingerprinting of sediments, to date soil profiles, to assess soil residence times and to quantify downslope soil fluxes using accumulated 10Be inventories along a hill slope. However, less attention is given to the potential use of the tracer to directly asses human induced changes in soil fluxes through deforestation, cultivation and reforestation. A good understanding of the processes governing the distribution of meteoric 10Be both within the soil profile and at landscape scale is essential before meteoric 10Be can be successfully applied to assess human impact. We developed a spatially explicit 2D-model (Be2D) in order to gain insight in meteoric 10Be movement along a hillslope that is subject to human disturbance. Be2D integrates both horizontal soil fluxes and vertical meteoric 10Be movement throughout the soil prolife. Horizontal soil fluxes are predicted using (i) well studied geomorphical laws for natural erosion and soil formation as well as (ii) human accelerated water and tillage erosion. Vertical movement of meteoric 10Be throughout the soil profile is implemented by inserting depth dependent retardation calculated using experimentally determined partition coefficients (Kd). The model was applied to different environments such as (i) the Belgian loess belt, characterized by aeolian deposits enriched in inherited meteoric 10Be, (ii) highly degraded and stony

  11. Risk factor noise - otological aspects

    Energy Technology Data Exchange (ETDEWEB)

    Haas, E

    1984-06-11

    After a short review of the anatomy and physiology of the inner ear the pathogenesis of chronic noise-induced hearing loss is discussed. The exposure to noise results first in a temporary but reversible threshold shift. But if the exposure to noise was exceedingly high or if the rest period would have required further noise reduction, a state of so-called auditory fatigue develops, finally leading to noise-induced hearing loss, a state which is considered irreversible. The noise-perception varies greatly among individuals and thus it is impossible to determine a certain noise intensity above which noise leasions will to be expected. It is generally accepted, that longterm exposure to noise above 85 dB (A) may lead to hearing loss in a portion of the exposed persons.

  12. Human-induced Terrestrial Water Storage Change: A Global Analysis using Hydrological Models and GRACE

    Science.gov (United States)

    Felfelani, F.; Pokhrel, Y. N.

    2016-12-01

    Hydrological models and data derived from the Gravity Recovery and Climate Experiment (GRACE) satellite mission are used to study terrestrial water storage (TWS) change; however, both have disadvantages that necessitate the integrated use of them. While GRACE doesn't disintegrate the vertical storage into its components, most models do not account for human activities. Here we use two Land Surface Models (LSMs), i.e., HiGW-MAT and PCRGLOBWB that fully couple natural and human drivers of changes in water cycle, explicitly simulating the changes in various TWS compartments. We first evaluate the models performance with GRACE observations. Then, we quantify the human footprint over global river basins located in different geographic and climate regions. To quantify human impacts, a new framework is proposed based on the GRACE observations (representing both climate variability and human activities) together with the natural simulation of LSMs using water budget equation (P-ET-R; P for precipitation, ET for evapotranspiration, and R for runoff). Finally, we examine the uncertainty in TWS simulations arising from the uncertainties in forcing data. Results indicate that, in snow-dominated regions, PCRGLOBWB generally fails to reproduce neither the interannual variability of observed TWS nor the seasonal cycle, while HiGW-MAT model shows significantly better results. In basins with human signatures, PCRGLOBWB generally shows better agreement with GRACE compared to HiGW-MAT. It is found that HiGW-MAT tends to overestimate groundwater depletion in basins with human impacts (e.g., Amudarya, Colorado, Euphrates and Indus), which results in larger negative interannual TWS trend compared to GRACE. Euphrates and Ganges river basins experience the highest human-induced TWS deficit rates (2.08 cm/yr and 1.94 cm/yr, respectively) during the simulation period of 2002-2010. Uncertainty analysis of results from the same model but with different forcing data suggests a high standard

  13. In vitro chondrogenesis and in vivo repair of osteochondral defect with human induced pluripotent stem cells.

    Science.gov (United States)

    Ko, Ji-Yun; Kim, Kyung-Il; Park, Siyeon; Im, Gun-Il

    2014-04-01

    The purpose of this study was to investigate the chondrogenic features of human induced pluripotent stem cells (hiPSCs) and examine the differences in the chondrogenesis between hiPSCs and human bone marrow-derived MSCs (hBMMSCs). Embryoid bodies (EBs) were formed from undifferentiated hiPSCs. After EBs were dissociated into single cells, chondrogenic culture was performed in pellets and alginate hydrogel. Chondro-induced hiPSCs were implanted in osteochondral defects created on the patellar groove of immunosuppressed rats and evaluated after 12 weeks. The ESC markers NANOG, SSEA4 and OCT3/4 disappeared while the mesodermal marker BMP-4 appeared in chondro-induced hiPSCs. After 21 days of culture, greater glycosaminoglycan contents and better chondrocytic features including lacuna and abundant matrix formation were observed from chondro-induced hiPSCs compared to chondro-induced hBMMSCs. The expression of chondrogenic markers including SOX-9, type II collagen, and aggrecan in chondro-induced hiPSCs was comparable to or greater than chondro-induced hBMMSCs. A remarkably low level of hypertrophic and osteogenic markers including type X collagen, type I collagen and Runx-2 was noted in chondro-induced hiPSCs compared to chondro-induced hBMMSCs. hiPSCs had significantly greater methylation of several CpG sites in COL10A1 promoter than hBMMSCs in either undifferentiated or chondro-induced state, suggesting an epigenetic cause of the difference in hypertrophy. The defects implanted with chondro-induced hiPSCs showed a significantly better quality of cartilage repair than the control defects, and the majority of cells in the regenerated cartilage consisted of implanted hiPSCs. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Genetic Correction and Hepatic Differentiation of Hemophilia B-specific Human Induced Pluripotent Stem Cells.

    Science.gov (United States)

    He, Qiong; Wang, Hui-Hui; Cheng, Tao; Yuan, Wei-Ping; Ma, Yu-Po; Jiang, Yong-Ping; Ren, Zhi-Hua

    2017-09-27

    Objective To genetically correct a disease-causing point mutation in human induced pluripotent stem cells (iPSCs) derived from a hemophilia B patient. Methods First, the disease-causing mutation was detected by sequencing the encoding area of human coagulation factor IX (F IX) gene. Genomic DNA was extracted from the iPSCs, and the primers were designed to amplify the eight exons of F IX. Next, the point mutation in those iPSCs was genetically corrected using CRISPR/Cas9 technology in the presence of a 129-nucleotide homologous repair template that contained two synonymous mutations. Then, top 8 potential off-target sites were subsequently analyzed using Sanger sequencing. Finally, the corrected clones were differentiated into hepatocyte-like cells, and the secretion of F IX was validated by immunocytochemistry and ELISA assay. Results The cell line bore a missense mutation in the 6 th coding exon (c.676 C>T) of F IX gene. Correction of the point mutation was achieved via CRISPR/Cas9 technology in situ with a high efficacy at about 22% (10/45) and no off-target effects detected in the corrected iPSC clones. F IX secretion, which was further visualized by immunocytochemistry and quantified by ELISA in vitro, reached about 6 ng/ml on day 21 of differentiation procedure. Conclusions Mutations in human disease-specific iPSCs could be precisely corrected by CRISPR/Cas9 technology, and corrected cells still maintained hepatic differentiation capability. Our findings might throw a light on iPSC-based personalized therapies in the clinical application, especially for hemophilia B.

  15. Disease modeling using human induced pluripotent stem cells: lessons from the liver.

    Science.gov (United States)

    Gieseck, Richard L; Colquhoun, Jennifer; Hannan, Nicholas R F

    2015-01-01

    Human pluripotent stem cells (hPSCs) have the capacity to differentiate into any of the hundreds of distinct cell types that comprise the human body. This unique characteristic has resulted in considerable interest in the field of regenerative medicine, given the potential for these cells to be used to protect, repair, or replace diseased, injured, and aged cells within the human body. In addition to their potential in therapeutics, hPSCs can be used to study the earliest stages of human development and to provide a platform for both drug screening and disease modeling using human cells. Recently, the description of human induced pluripotent stem cells (hIPSCs) has allowed the field of disease modeling to become far more accessible and physiologically relevant, as pluripotent cells can be generated from patients of any genetic background. Disease models derived from hIPSCs that manifest cellular disease phenotypes have been established to study several monogenic diseases; furthermore, hIPSCs can be used for phenotype-based drug screens to investigate complex diseases for which the underlying genetic mechanism is unknown. As a result, the use of stem cells as research tools has seen an unprecedented growth within the last decade as researchers look for in vitro disease models which closely mimic in vivo responses in humans. Here, we discuss the beginnings of hPSCs, starting with isolation of human embryonic stem cells, moving into the development and optimization of hIPSC technology, and ending with the application of hIPSCs towards disease modeling and drug screening applications, with specific examples highlighting the modeling of inherited metabolic disorders of the liver. This article is part of a Special Issue entitled Linking transcription to physiology in lipodomics. Crown Copyright © 2014. Published by Elsevier B.V. All rights reserved.

  16. Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin.

    Science.gov (United States)

    Dorn, Isabel; Klich, Katharina; Arauzo-Bravo, Marcos J; Radstaak, Martina; Santourlidis, Simeon; Ghanjati, Foued; Radke, Teja F; Psathaki, Olympia E; Hargus, Gunnar; Kramer, Jan; Einhaus, Martin; Kim, Jeong Beom; Kögler, Gesine; Wernet, Peter; Schöler, Hans R; Schlenke, Peter; Zaehres, Holm

    2015-01-01

    Epigenetic memory in induced pluripotent stem cells, which is related to the somatic cell type of origin of the stem cells, might lead to variations in the differentiation capacities of the pluripotent stem cells. In this context, induced pluripotent stem cells from human CD34(+) hematopoietic stem cells might be more suitable for hematopoietic differentiation than the commonly used fibroblast-derived induced pluripotent stem cells. To investigate the influence of an epigenetic memory on the ex vivo expansion of induced pluripotent stem cells into erythroid cells, we compared induced pluripotent stem cells from human neural stem cells and human cord blood-derived CD34(+) hematopoietic stem cells and evaluated their potential for differentiation into hematopoietic progenitor and mature red blood cells. Although genome-wide DNA methylation profiling at all promoter regions demonstrates that the epigenetic memory of induced pluripotent stem cells is influenced by the somatic cell type of origin of the stem cells, we found a similar hematopoietic induction potential and erythroid differentiation pattern of induced pluripotent stem cells of different somatic cell origin. All human induced pluripotent stem cell lines showed terminal maturation into normoblasts and enucleated reticulocytes, producing predominantly fetal hemoglobin. Differences were only observed in the growth rate of erythroid cells, which was slightly higher in the induced pluripotent stem cells derived from CD34(+) hematopoietic stem cells. More detailed methylation analysis of the hematopoietic and erythroid promoters identified similar CpG methylation levels in the induced pluripotent stem cell lines derived from CD34(+) cells and those derived from neural stem cells, which confirms their comparable erythroid differentiation potential. Copyright© Ferrata Storti Foundation.

  17. Comparison of the glycosphingolipids of human-induced pluripotent stem cells and human embryonic stem cells.

    Science.gov (United States)

    Säljö, Karin; Barone, Angela; Vizlin-Hodzic, Dzeneta; Johansson, Bengt R; Breimer, Michael E; Funa, Keiko; Teneberg, Susann

    2017-04-01

    High expectations are held for human-induced pluripotent stem cells (hiPSC) since they are established from autologous tissues thus overcoming the risk of allogeneic immune rejection when used in regenerative medicine. However, little is known regarding the cell-surface carbohydrate antigen profile of hiPSC compared with human embryonic stem cells (hESC). Here, glycosphingolipids were isolated from an adipocyte-derived hiPSC line, and hiPSC and hESC glycosphingolipids were compared by concurrent characterization by binding assays with carbohydrate-recognizing ligands and mass spectrometry. A high similarity between the nonacid glycosphingolipids of hiPSC and hESC was found. The nonacid glycosphingolipids P1 pentaosylceramide, x2 pentaosylceramide and H type 1 heptaosylceramide, not previously described in human pluripotent stem cells (hPSC), were characterized in both hiPSC and hESC. The composition of acid glycosphingolipids differed, with increased levels of GM3 ganglioside, and reduced levels of GD1a/GD1b in hiPSC when compared with hESC. In addition, the hESC glycosphingolipids sulf-globopentaosylceramide and sialyl-globotetraosylceramide were lacking in hiPSC. Neural stem cells differentiating from hiPSC had a reduced expression of sialyl-lactotetra, whereas expression of the GD1a ganglioside was significantly increased. Thus, while sialyl-lactotetra is a marker of undifferentiated hPSC, GD1a is a novel marker of neural differentiation. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  18. Generation of Functional Lentoid Bodies From Human Induced Pluripotent Stem Cells Derived From Urinary Cells.

    Science.gov (United States)

    Fu, Qiuli; Qin, Zhenwei; Jin, Xiuming; Zhang, Lifang; Chen, Zhijian; He, Jiliang; Ji, Junfeng; Yao, Ke

    2017-01-01

    The pathological mechanisms underlying cataract formation remain largely unknown on account of the lack of appropriate in vitro cellular models. The aim of this study is to develop a stable in vitro system for human lens regeneration using pluripotent stem cells. Isolated human urinary cells were infected with four Yamanaka factors to generate urinary human induced pluripotent stem cells (UiPSCs), which were induced to differentiate into lens progenitor cells and lentoid bodies (LBs). The expression of lens-specific markers was examined by real-time PCR, immunostaining, and Western blotting. The structure and magnifying ability of LBs were investigated using transmission electron microscopy and observing the magnification of the letter "X," respectively. We developed a "fried egg" differentiation method to generate functional LBs from UiPSCs. The UiPSC-derived LBs exhibited crystalline lens-like morphology and a transparent structure and expressed lens-specific markers αA-, αB-, β-, and γ-crystallin and MIP. During LB differentiation, the placodal markers SIX1, EYA1, DLX3, PAX6, and the specific early lens markers SOX1, PROX1, FOXE3, αA-, and αB-crystallin were observed at certain time points. Microscopic examination revealed the presence of lens epithelial cells adjacent to the lens capsule as well as both immature and mature fiber-like cells. Optical analysis further demonstrated the magnifying ability (1.7×) of the LBs generated from UiPSCs. Our study provides the first evidence toward generating functional LBs from UiPSCs, thereby establishing an in vitro system that can be used to study human lens development and cataractogenesis and perhaps even be useful for drug screening.

  19. Thermo-responsive polymeric nanoparticles for enhancing neuronal differentiation of human induced pluripotent stem cells.

    Science.gov (United States)

    Seo, Hye In; Cho, Ann-Na; Jang, Jiho; Kim, Dong-Wook; Cho, Seung-Woo; Chung, Bong Geun

    2015-10-01

    We report thermo-responsive retinoic acid (RA)-loaded poly(N-isopropylacrylamide)-co-acrylamide (PNIPAM-co-Am) nanoparticles for directing human induced pluripotent stem cell (hiPSC) fate. Fourier transform infrared spectroscopy and (1)H nuclear magnetic resonance analysis confirmed that RA was efficiently incorporated into PNIAPM-co-Am nanoparticles (PCANs). The size of PCANs dropped with increasing temperatures (300-400 nm at room temperature, 80-90 nm at 37°C) due to its phase transition from hydrophilic to hydrophobic. Due to particle shrinkage caused by this thermo-responsive property of PCANs, RA could be released from nanoparticles in the cells upon cellular uptake. Immunocytochemistry and quantitative real-time polymerase chain reaction analysis demonstrated that neuronal differentiation of hiPSC-derived neuronal precursors was enhanced after treatment with 1-2 μg/ml RA-loaded PCANs. Therefore, we propose that this PCAN could be a potentially powerful carrier for effective RA delivery to direct hiPSC fate to neuronal lineage. The use of induced pluripotent stem cells (iPSCs) has been at the forefront of research in the field of regenerative medicine, as these cells have the potential to differentiate into various terminal cell types. In this article, the authors utilized a thermo-responsive polymer, Poly(N-isopropylacrylamide) (PNIPAM), as a delivery platform for retinoic acid. It was shown that neuronal differentiation could be enhanced in hiPSC-derived neuronal precursor cells. This method may pave a way for future treatment of neuronal diseases. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. Developmental changes in electrophysiological characteristics of human induced Pluripotent Stem Cell-derived cardiomyocytes

    Science.gov (United States)

    Ben-Ari, Meital; Naor, Shulamit; Zeevi-Levin, Naama; Schick, Revital; Ben Jehuda, Ronen; Reiter, Irina; Raveh, Amit; Grijnevitch, Inna; Barak, Omri; Rosen, Michael R.; Weissman, Amir; Binah, Ofer

    2016-01-01

    Background Previous studies proposed that throughout differentiation of human induced Pluripotent Stem Cell-derived cardiomyocytes (iPSC-CMs) only 3 types of action potentials (AP) exist: nodal, atrial and ventricular-like. Objective To investigate whether there are precisely 3 phenotypes or a continuum exists among them, we tested 2 hypotheses: (1) during culture development a cardiac precursor cell is present that - depending on age - can evolve into the 3 phenotypes. (2) The predominant pattern is early prevalence of nodal phenotype, transient appearance of atrial phenotype, evolution to ventricular phenotype, and persistence of transitional phenotypes. Methods To test these hypotheses we: (1) performed FACS analysis of nodal, atrial and ventricular markers; (2) recorded AP from 280 7-to-95 day old iPSC-CMs; (3) analyzed AP characteristics. Results The major findings were: (1) FACS analysis of 30 and 60-day old cultures showed that an iPSC-CMs population shifts from nodal into atrial/ventricular phenotype, while including significant transitional populations.(2) The AP population did not consist of 3 distinct phenotypes; (3) Culture aging was associated with a shift from nodal to ventricular dominance, with a transient (57–70 days) appearance of atrial phenotype; (4) Beat Rate Variability was more prominent in nodal than ventricular cardiomyocytes while If density increased in older cultures. Conclusions From the onset of development the iPSC-CMs population includes nodal, atrial and ventricular AP and a broad spectrum of transitional phenotypes. The most readily distinguishable phenotype is atrial which appears only transiently, yet dominates at 57–70 days of evolution. PMID:27639456

  1. Developmental changes in electrophysiological characteristics of human-induced pluripotent stem cell-derived cardiomyocytes.

    Science.gov (United States)

    Ben-Ari, Meital; Naor, Shulamit; Zeevi-Levin, Naama; Schick, Revital; Ben Jehuda, Ronen; Reiter, Irina; Raveh, Amit; Grijnevitch, Inna; Barak, Omri; Rosen, Michael R; Weissman, Amir; Binah, Ofer

    2016-12-01

    Previous studies proposed that throughout differentiation of human induced Pluripotent Stem Cell-derived cardiomyocytes (iPSC-CMs), only 3 types of action potentials (APs) exist: nodal-, atrial-, and ventricular-like. To investigate whether there are precisely 3 phenotypes or a continuum exists among them, we tested 2 hypotheses: (1) During culture development a cardiac precursor cell is present that-depending on age-can evolve into the 3 phenotypes. (2) The predominant pattern is early prevalence of a nodal phenotype, transient appearance of an atrial phenotype, evolution to a ventricular phenotype, and persistence of transitional phenotypes. To test these hypotheses, we (1) performed fluorescence-activated cell sorting analysis of nodal, atrial, and ventricular markers; (2) recorded APs from 280 7- to 95-day-old iPSC-CMs; and (3) analyzed AP characteristics. The major findings were as follows: (1) fluorescence-activated cell sorting analysis of 30- and 60-day-old cultures showed that an iPSC-CMs population shifts from the nodal to the atrial/ventricular phenotype while including significant transitional populations; (2) the AP population did not consist of 3 phenotypes; (3) culture aging was associated with a shift from nodal to ventricular dominance, with a transient (57-70 days) appearance of the atrial phenotype; and (4) beat rate variability was more prominent in nodal than in ventricular cardiomyocytes, while pacemaker current density increased in older cultures. From the onset of development in culture, the iPSC-CMs population includes nodal, atrial, and ventricular APs and a broad spectrum of transitional phenotypes. The most readily distinguishable phenotype is atrial, which appears only transiently yet dominates at 57-70 days of evolution. Copyright © 2016 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  2. Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes.

    Science.gov (United States)

    Chaudhari, Umesh; Nemade, Harshal; Sureshkumar, Poornima; Vinken, Mathieu; Ates, Gamze; Rogiers, Vera; Hescheler, Jürgen; Hengstler, Jan Georg; Sachinidis, Agapios

    2018-01-01

    There is a large demand of a human relevant in vitro test system suitable for assessing the cardiotoxic potential of cosmetic ingredients and other chemicals. Using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), we have already established an in vitro cardiotoxicity assay and identified genomic biomarkers of anthracycline-induced cardiotoxicity in our previous work. Here, five cosmetic ingredients were studied by the new hiPSC-CMs test; kojic acid (KJA), triclosan (TS), triclocarban (TCC), 2,7-naphthalenediol (NPT), and basic red 51 (BR51) based on cytotoxicity as well as ATP assays, beating rate, and genomic biomarkers to determine the lowest observed effect concentration (LOEC) and no observed effect concentration (NOEC). The LOEC for beating rate were 400, 10, 3, >400, and 3 µM for KJA, TS, TCC, NPT, and BR51, respectively. The corresponding concentrations for cytotoxicity or ATP depletion were similar, with the exception of TS and TCC, where the cardiomyocyte-beating assay showed positive results at non-cytotoxic concentrations. Functional analysis also showed that the individual compounds caused different effects on hiPSC-CMs. While exposure to KJA, TS, TCC, and BR51 induced significant arrhythmic beating, NPT slightly decreased cell viability, but did not influence beating. Gene expression studies showed that TS and NPT caused down-regulation of cytoskeletal and cardiac ion homeostasis genes. Moreover, TS and NPT deregulated genomic biomarkers known to be affected also by anthracyclines. The present study demonstrates that hiPSC-CMs can be used to determine LOECs and NOECs in vitro, which can be compared to human blood concentrations to determine margins of exposure. Our in vitro assay, which so far has been tested with several anthracyclines and cosmetics, still requires validation by larger numbers of positive and negative controls, before it can be recommended for routine analysis.

  3. Proarrhythmia risk prediction using human induced pluripotent stem cell-derived cardiomyocytes.

    Science.gov (United States)

    Yamazaki, Daiju; Kitaguchi, Takashi; Ishimura, Masakazu; Taniguchi, Tomohiko; Yamanishi, Atsuhiro; Saji, Daisuke; Takahashi, Etsushi; Oguchi, Masao; Moriyama, Yuta; Maeda, Sanae; Miyamoto, Kaori; Morimura, Kaoru; Ohnaka, Hiroki; Tashibu, Hiroyuki; Sekino, Yuko; Miyamoto, Norimasa; Kanda, Yasunari

    2018-04-01

    Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are expected to become a useful tool for proarrhythmia risk prediction in the non-clinical drug development phase. Several features including electrophysiological properties, ion channel expression profile and drug responses were investigated using commercially available hiPSC-CMs, such as iCell-CMs and Cor.4U-CMs. Although drug-induced arrhythmia has been extensively examined by microelectrode array (MEA) assays in iCell-CMs, it has not been fully understood an availability of Cor.4U-CMs for proarrhythmia risk. Here, we evaluated the predictivity of proarrhythmia risk using Cor.4U-CMs. MEA assay revealed linear regression between inter-spike interval and field potential duration (FPD). The hERG inhibitor E-4031 induced reverse-use dependent FPD prolongation. We next evaluated the proarrhythmia risk prediction by a two-dimensional map, which we have previously proposed. We determined the relative torsade de pointes risk score, based on the extent of FPD with Fridericia's correction (FPDcF) change and early afterdepolarization occurrence, and calculated the margins normalized to free effective therapeutic plasma concentrations. The drugs were classified into three risk groups using the two-dimensional map. This risk-categorization system showed high concordance with the torsadogenic information obtained by a public database CredibleMeds. Taken together, these results indicate that Cor.4U-CMs can be used for drug-induced proarrhythmia risk prediction. Copyright © 2018 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

  4. Usefulness of cardiotoxicity assessment using calcium transient in human induced pluripotent stem cell-derived cardiomyocytes.

    Science.gov (United States)

    Watanabe, Hitoshi; Honda, Yayoi; Deguchi, Jiro; Yamada, Toru; Bando, Kiyoko

    2017-01-01

    Monitoring dramatic changes in intracellular calcium ion levels during cardiac contraction and relaxation, known as calcium transient, in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) would be an attractive strategy for assessing compounds on cardiac contractility. In addition, as arrhythmogenic compounds are known to induce characteristic waveform changes in hiPSC-CMs, it is expected that calcium transient would allow evaluation of not only compound-induced effects on cardiac contractility, but also compound arrhythmogenic potential. Using a combination of calcium transient in hiPSC-CMs and a fast kinetic fluorescence imaging detection system, we examined in this study changes in calcium transient waveforms induced by a series of 17 compounds that include positive/negative inotropic agents as well as cardiac ion channel activators/inhibitors. We found that all positive inotropic compounds induced an increase in peak frequency and/or peak amplitude. The effects of a negative inotropic compound could clearly be detected in the presence of a β-adrenergic receptor agonist. Furthermore, most arrhythmogenic compounds raised the ratio of peak decay time to peak rise time (D/R ratio) in calcium transient waveforms. Compound concentrations at which these parameters exceeded cutoff values correlated well with systemic exposure levels at which arrhythmias were reported to be evoked. In conclusion, we believe that peak analysis of calcium transient and determination of D/R ratio are reliable methods for assessing compounds' cardiac contractility and arrhythmogenic potential, respectively. Using these approaches would allow selection of compounds with low cardiotoxic potential at the early stage of drug discovery.

  5. A direct pedestrian-structure interaction model to characterize the human induced vibrations on slender footbridges

    Directory of Open Access Journals (Sweden)

    Jiménez-Alonso, J. F.

    2014-12-01

    Full Text Available Although the scientific community had knowledge of the human induced vibration problems in structures since the end of the 19th century, it was not until the occurrence of the vibration phenomenon happened in the Millennium Bridge (London, 2000 that the importance of the problem revealed and a higher level of attention devoted. Despite the large advances achieved in the determination of the human-structure interaction force, one of the main deficiencies of the existing models is the exclusion of the effect of changes in the footbridge dynamic properties due to the presence of pedestrians. In this paper, the formulation of a human-structure interaction model, addresses these limitations, is carried out and its reliability is verified from previously published experimental results.Aunque la comunidad científica tenía conocimiento de los problemas vibratorios inducidos por peatones en estructuras desde finales del siglo xix, no fue hasta la ocurrencia de los eventos vibratorios acontecidos en la pasarela del Milenio (Londres, 2000, cuando la importancia del problema se puso de manifiesto y se le comenzó a dedicar un mayor nivel de atención. A pesar de los grandes avances alcanzados en la caracterización de la fuerza de interacción peatón-estructura una de las principales deficiencias de los modelos existentes es la exclusión del cambio en las propiedades dinámicas de la pasarela por la presencia de peatones. En este artículo, se presenta la formulación de un modelo de interacción peatón-estructura que intenta dar respuesta a dichas limitaciones, y su validación a partir de resultados experimentales previamente publicados por otros autores.

  6. Wnt/Yes-Associated Protein Interactions During Neural Tissue Patterning of Human Induced Pluripotent Stem Cells.

    Science.gov (United States)

    Bejoy, Julie; Song, Liqing; Zhou, Yi; Li, Yan

    2018-04-01

    Human induced pluripotent stem cells (hiPSCs) have special ability to self-assemble into neural spheroids or mini-brain-like structures. During the self-assembly process, Wnt signaling plays an important role in regional patterning and establishing positional identity of hiPSC-derived neural progenitors. Recently, the role of Wnt signaling in regulating Yes-associated protein (YAP) expression (nuclear or cytoplasmic), the pivotal regulator during organ growth and tissue generation, has attracted increasing interests. However, the interactions between Wnt and YAP expression for neural lineage commitment of hiPSCs remain poorly explored. The objective of this study is to investigate the effects of Wnt signaling and YAP expression on the cellular population in three-dimensional (3D) neural spheroids derived from hiPSCs. In this study, Wnt signaling was activated using CHIR99021 for 3D neural spheroids derived from human iPSK3 cells through embryoid body formation. Our results indicate that Wnt activation induces nuclear localization of YAP and upregulates the expression of HOXB4, the marker for hindbrain/spinal cord. By contrast, the cells exhibit more rostral forebrain neural identity (expression of TBR1) without Wnt activation. Cytochalasin D was then used to induce cytoplasmic YAP and the results showed the decreased HOXB4 expression. In addition, the incorporation of microparticles in the neural spheroids was investigated for the perturbation of neural patterning. This study may indicate the bidirectional interactions of Wnt signaling and YAP expression during neural tissue patterning, which have the significance in neurological disease modeling, drug screening, and neural tissue regeneration.

  7. Human induced pluripotent stem cell-derived beating cardiac tissues on paper.

    Science.gov (United States)

    Wang, Li; Xu, Cong; Zhu, Yujuan; Yu, Yue; Sun, Ning; Zhang, Xiaoqing; Feng, Ke; Qin, Jianhua

    2015-11-21

    There is a growing interest in using paper as a biomaterial scaffold for cell-based applications. In this study, we made the first attempt to fabricate a paper-based array for the culture, proliferation, and direct differentiation of human induced pluripotent stem cells (hiPSCs) into functional beating cardiac tissues and create "a beating heart on paper." This array was simply constructed by binding a cured multi-well polydimethylsiloxane (PDMS) mold with common, commercially available paper substrates. Three types of paper material (print paper, chromatography paper and nitrocellulose membrane) were tested for adhesion, proliferation and differentiation of human-derived iPSCs. We found that hiPSCs grew well on these paper substrates, presenting a three-dimensional (3D)-like morphology with a pluripotent property. The direct differentiation of human iPSCs into functional cardiac tissues on paper was also achieved using our modified differentiation approach. The cardiac tissue retained its functional activities on the coated print paper and chromatography paper with a beating frequency of 40-70 beats per min for up to three months. Interestingly, human iPSCs could be differentiated into retinal pigment epithelium on nitrocellulose membrane under the conditions of cardiac-specific induction, indicating the potential roles of material properties and mechanical cues that are involved in regulating stem cell differentiation. Taken together, these results suggest that different grades of paper could offer great opportunities as bioactive, low-cost, and 3D in vitro platforms for stem cell-based high-throughput drug testing at the tissue/organ level and for tissue engineering applications.

  8. Maximizing noise energy for noise-masking studies.

    Science.gov (United States)

    Jules Étienne, Cédric; Arleo, Angelo; Allard, Rémy

    2017-08-01

    Noise-masking experiments are widely used to investigate visual functions. To be useful, noise generally needs to be strong enough to noticeably impair performance, but under some conditions, noise does not impair performance even when its contrast approaches the maximal displayable limit of 100 %. To extend the usefulness of noise-masking paradigms over a wider range of conditions, the present study developed a noise with great masking strength. There are two typical ways of increasing masking strength without exceeding the limited contrast range: use binary noise instead of Gaussian noise or filter out frequencies that are not relevant to the task (i.e., which can be removed without affecting performance). The present study combined these two approaches to further increase masking strength. We show that binarizing the noise after the filtering process substantially increases the energy at frequencies within the pass-band of the filter given equated total contrast ranges. A validation experiment showed that similar performances were obtained using binarized-filtered noise and filtered noise (given equated noise energy at the frequencies within the pass-band) suggesting that the binarization operation, which substantially reduced the contrast range, had no significant impact on performance. We conclude that binarized-filtered noise (and more generally, truncated-filtered noise) can substantially increase the energy of the noise at frequencies within the pass-band. Thus, given a limited contrast range, binarized-filtered noise can display higher energy levels than Gaussian noise and thereby widen the range of conditions over which noise-masking paradigms can be useful.

  9. Hybrid Experiential-Heuristic Cognitive Radio Engine Architecture and Implementation

    Directory of Open Access Journals (Sweden)

    Ashwin Amanna

    2012-01-01

    Full Text Available The concept of cognitive radio (CR focuses on devices that can sense their environment, adapt configuration parameters, and learn from past behaviors. Architectures tend towards simplified decision-making algorithms inspired by human cognition. Initial works defined cognitive engines (CEs founded on heuristics, such as genetic algorithms (GAs, and case-based reasoning (CBR experiential learning algorithms. This hybrid architecture enables both long-term learning, faster decisions based on past experience, and capability to still adapt to new environments. This paper details an autonomous implementation of a hybrid CBR-GA CE architecture on a universal serial radio peripheral (USRP software-defined radio focused on link adaptation. Details include overall process flow, case base structure/retrieval method, estimation approach within the GA, and hardware-software lessons learned. Unique solutions to realizing the concept include mechanisms for combining vector distance and past fitness into an aggregate quantification of similarity. Over-the-air performance under several interference conditions is measured using signal-to-noise ratio, packet error rate, spectral efficiency, and throughput as observable metrics. Results indicate that the CE is successfully able to autonomously change transmit power, modulation/coding, and packet size to maintain the link while a non-cognitive approach loses connectivity. Solutions to existing shortcomings are proposed for improving case-base searching and performance estimation methods.

  10. DSP-Enabled Radio Astronomy: Towards IIIZW35 Reconquest

    Directory of Open Access Journals (Sweden)

    Alain Lecacheux

    2005-09-01

    Full Text Available In radio astronomy, the radio spectrum is used to detect weak emission from celestial sources. By spectral averaging, observation noise is reduced and weak sources can be detected. However, more and more observations are polluted by man-made radio frequency interferences (RFI. The impact of these RFIs on power spectral measurement ranges from total saturation to subtle distortions of the data. To some extent, elimination of artefacts can be achieved by blanking polluted channels in real time. With this aim in view, a complete real-time digital system has been implemented on a set of FPGA and DSP. The current functionalities of the digital system have high dynamic range of 70 dB, bandwidth selection facilities ranging from 875 kHz to 14 MHz, high spectral resolution through a polyphase filter bank with up to 8192 channels with 49 152 coefficients and real-time time-frequency blanking with a robust threshold detector. This receiver has been used to reobserve the IIIWZ35 astronomical source which has been scrambled by a strong satellite RFI for several years.

  11. Wind turbine noise diagnostics

    International Nuclear Information System (INIS)

    Richarz, W.; Richarz, H.

    2009-01-01

    This presentation proposed a self-consistent model for broad-band noise emitted from modern wind turbines. The simple source model was consistent with the physics of sound generation and considered the unique features of wind turbines. Although the acoustics of wind turbines are similar to those of conventional propellers, the dimensions of wind turbines pose unique challenges in diagnosing noise emission. The general features of the sound field were deduced. Source motion and source directivity appear to be responsible for amplitude variations. The amplitude modulation is likely to make wind-turbine noise more audible, and may be partly responsible for annoyance that has been reported in the literature. Acoustic array data suggests that broad-band noise is emitted predominantly during the downward sweep of each rotor blade. Source motion and source directivity account for the observed pattern. Rotor-tower interaction effects are of lesser importance. Predicted amplitude modulation ranges from 1 dB to 6dB. 2 refs., 9 figs.

  12. Exploring Noise: Sound Pollution.

    Science.gov (United States)

    Rillo, Thomas J.

    1979-01-01

    Part one of a three-part series about noise pollution and its effects on humans. This section presents the background information for teachers who are preparing a unit on sound. The next issues will offer learning activities for measuring the effects of sound and some references. (SA)

  13. Perkembangan dan Problematika Radio Komunitas di Indonesia

    Directory of Open Access Journals (Sweden)

    Masduki .

    2013-12-01

    Full Text Available Abstract: This article is about the development of community radio in Indonesia, it is problems and solutions. Community radio in Indonesia developed as an alternative to both public radio and commercial radio after the fall of Soeharto in 1998. Two important features of community radio are that it provides all community members with equal access to information, enhancing their rights and obligations, access to justice, public accountability and also enables them to participate actively in radio management and production. Both features enhance people’s selfawareness and sense of belonging to a community. The expansion of the progressive, participatory, community ownership, and non-profit model of community radio, has become a third sector of communication beside the commercial or state media. The dynamic development of community radio in Indonesia faced several problems starting from it is definition, implementation of regulation until standards of programmes operation based on the concept of community approach and participation

  14. Interweave Cognitive Radio with Improper Gaussian Signaling

    KAUST Repository

    Hedhly, Wafa; Amin, Osama; Alouini, Mohamed-Slim

    2018-01-01

    Improper Gaussian signaling (IGS) has proven its ability in improving the performance of underlay and overlay cognitive radio paradigms. In this paper, the interweave cognitive radio paradigm is studied when the cognitive user employs IGS

  15. Contribution Towards Practical Cognitive Radios Systems

    KAUST Repository

    Ben Ghorbel, Mahdi

    2013-01-01

    to cognitive radio systems while taking into account practical constraints. Cogni- tive radios requires a capability to detect spectrum holes (spectrum sensing) and a scheduling flexibility to avoid the occupied spectrum and selectively use the empty spectrum

  16. Educational Radio: The Brazilian Experience.

    Science.gov (United States)

    Speyer, Anne Marie

    1983-01-01

    Explains the value of radio for literacy education, gives a synopsis of the development of educational broadcasting in Brazil, and describes the Movement of Basic Education, a program designed to meet the needs of members of rural communities in their daily working lives. (EAO)

  17. Hybrid spread spectrum radio system

    Science.gov (United States)

    Smith, Stephen F [London, TN; Dress, William B [Camas, WA

    2010-02-09

    Systems and methods are described for hybrid spread spectrum radio systems. A method, includes receiving a hybrid spread spectrum signal including: fast frequency hopping demodulating and direct sequence demodulating a direct sequence spread spectrum signal, wherein multiple frequency hops occur within a single data-bit time and each bit is represented by chip transmissions at multiple frequencies.

  18. Radio frequency modulation made easy

    CERN Document Server

    Faruque, Saleh

    2017-01-01

    This book introduces Radio Frequency Modulation to a broad audience. The author blends theory and practice to bring readers up-to-date in key concepts, underlying principles and practical applications of wireless communications. The presentation is designed to be easily accessible, minimizing mathematics and maximizing visuals.

  19. The isotropic radio background revisited

    Energy Technology Data Exchange (ETDEWEB)

    Fornengo, Nicolao; Regis, Marco [Dipartimento di Fisica Teorica, Università di Torino, via P. Giuria 1, I–10125 Torino (Italy); Lineros, Roberto A. [Instituto de Física Corpuscular – CSIC/U. Valencia, Parc Científic, calle Catedrático José Beltrán, 2, E-46980 Paterna (Spain); Taoso, Marco, E-mail: fornengo@to.infn.it, E-mail: rlineros@ific.uv.es, E-mail: regis@to.infn.it, E-mail: taoso@cea.fr [Institut de Physique Théorique, CEA/Saclay, F-91191 Gif-sur-Yvette Cédex (France)

    2014-04-01

    We present an extensive analysis on the determination of the isotropic radio background. We consider six different radio maps, ranging from 22 MHz to 2.3 GHz and covering a large fraction of the sky. The large scale emission is modeled as a linear combination of an isotropic component plus the Galactic synchrotron radiation and thermal bremsstrahlung. Point-like and extended sources are either masked or accounted for by means of a template. We find a robust estimate of the isotropic radio background, with limited scatter among different Galactic models. The level of the isotropic background lies significantly above the contribution obtained by integrating the number counts of observed extragalactic sources. Since the isotropic component dominates at high latitudes, thus making the profile of the total emission flat, a Galactic origin for such excess appears unlikely. We conclude that, unless a systematic offset is present in the maps, and provided that our current understanding of the Galactic synchrotron emission is reasonable, extragalactic sources well below the current experimental threshold seem to account for the majority of the brightness of the extragalactic radio sky.

  20. The isotropic radio background revisited

    International Nuclear Information System (INIS)

    Fornengo, Nicolao; Regis, Marco; Lineros, Roberto A.; Taoso, Marco

    2014-01-01

    We present an extensive analysis on the determination of the isotropic radio background. We consider six different radio maps, ranging from 22 MHz to 2.3 GHz and covering a large fraction of the sky. The large scale emission is modeled as a linear combination of an isotropic component plus the Galactic synchrotron radiation and thermal bremsstrahlung. Point-like and extended sources are either masked or accounted for by means of a template. We find a robust estimate of the isotropic radio background, with limited scatter among different Galactic models. The level of the isotropic background lies significantly above the contribution obtained by integrating the number counts of observed extragalactic sources. Since the isotropic component dominates at high latitudes, thus making the profile of the total emission flat, a Galactic origin for such excess appears unlikely. We conclude that, unless a systematic offset is present in the maps, and provided that our current understanding of the Galactic synchrotron emission is reasonable, extragalactic sources well below the current experimental threshold seem to account for the majority of the brightness of the extragalactic radio sky

  1. Utrecht and Galactic Radio Astronomy

    NARCIS (Netherlands)

    van Woerden, H.

    Important roles in early Dutch Galactic radio astronomy were played by several Utrecht astronomers: Van de Hulst, Minnaert and Houtgast. The poster announcing the conference contained a number of pictures referring to scientific achievements of the Astronomical Institute Utrecht. One of these

  2. A repeating fast radio burst.

    Science.gov (United States)

    Spitler, L G; Scholz, P; Hessels, J W T; Bogdanov, S; Brazier, A; Camilo, F; Chatterjee, S; Cordes, J M; Crawford, F; Deneva, J; Ferdman, R D; Freire, P C C; Kaspi, V M; Lazarus, P; Lynch, R; Madsen, E C; McLaughlin, M A; Patel, C; Ransom, S M; Seymour, A; Stairs, I H; Stappers, B W; van Leeuwen, J; Zhu, W W

    2016-03-10

    Fast radio bursts are millisecond-duration astronomical radio pulses of unknown physical origin that appear to come from extragalactic distances. Previous follow-up observations have failed to find additional bursts at the same dispersion measure (that is, the integrated column density of free electrons between source and telescope) and sky position as the original detections. The apparent non-repeating nature of these bursts has led to the suggestion that they originate in cataclysmic events. Here we report observations of ten additional bursts from the direction of the fast radio burst FRB 121102. These bursts have dispersion measures and sky positions consistent with the original burst. This unambiguously identifies FRB 121102 as repeating and demonstrates that its source survives the energetic events that cause the bursts. Additionally, the bursts from FRB 121102 show a wide range of spectral shapes that appear to be predominantly intrinsic to the source and which vary on timescales of minutes or less. Although there may be multiple physical origins for the population of fast radio bursts, these repeat bursts with high dispersion measure and variable spectra specifically seen from the direction of FRB 121102 support an origin in a young, highly magnetized, extragalactic neutron star.

  3. Quality in radio-immunology

    International Nuclear Information System (INIS)

    Hegesippe, Michel

    1982-01-01

    The author outlines the technique of radio-immunological analysis (RIA) which is now widely used for neo-natal detection of congenital hyperthyroidism. He describes the methods and controls that are called for - as regards the specificity of doses, the sensitivity and reliability of the separation technique - to guarantee the quality of RIA and the validity of its results [fr

  4. Attributable Human-Induced Changes in the Likelihood and Magnitude of the Observed Extreme Precipitation during Hurricane Harvey

    OpenAIRE

    Risser, MD; Wehner, MF

    2017-01-01

    ©2017. American Geophysical Union. All Rights Reserved. Record rainfall amounts were recorded during Hurricane Harvey in the Houston, Texas, area, leading to widespread flooding. We analyze observed precipitation from the Global Historical Climatology Network with a covariate-based extreme value statistical analysis, accounting for both the external influence of global warming and the internal influence of El Niño–Southern Oscillation. We find that human-induced climate change likely increase...

  5. Generation of human induced pluripotent stem cell lines from human dermal fibroblasts using a non-integration system

    Directory of Open Access Journals (Sweden)

    Kyung-Ok Uhm

    2017-05-01

    Full Text Available We generated human induced pluripotent stem cells (hiPSCs from dermal fibroblasts using a Sendai virus (SeV-based gene delivery method. The generated hiPSC line, KSCBi002-A, has a normal karyotype (46,XY. The pluripotency and differentiation capacity were characterized by comparison with those of a human embryonic stem cell line. This cell line is registered and available from the National Stem Cell Bank, Korea National Institute of Health.

  6. Noise cancellation properties of displacement noise free interferometer

    International Nuclear Information System (INIS)

    Sato, Shuichi; Kawamura, Seiji; Nishizawa, Atsushi; Chen Yanbei

    2010-01-01

    We have demonstrated the practical feasibility of a displacement- and frequency-noise-free laser interferometer (DFI) by partially implementing a recently proposed optical configuration using bi-directional Mach-Zehnder interferometers (MZIs). The noise cancellation efficiency was evaluated by comparing the displacement noise spectrum of the MZIs and the DFI, demonstrating up to 50 dB of noise cancellation. In addition, the possible extension of DFI as QND device is explored.

  7. Newnes radio and electronics engineer's pocket book

    CERN Document Server

    Moorshead, H W; Perry, J

    1978-01-01

    Newnes Radio and Electronics Engineer's Pocket Book, Fifteenth Edition provides reference of the information relevant in radio and electronics engineering. The book presents tables, illustrations, and diagrams of various data used in radio and electronics engineering. The coverage of the text includes abbreviations and symbols, electrical equations, and code conversions. The text will be useful to engineers, technicians, and other professionals who require a reference about the different aspects of radio and electronics.

  8. IRAS observations of radio-quiet and radio-loud quasars

    Science.gov (United States)

    Neugebauer, G.; Soifer, B. T.; Miley, G.; Habing, H. J.; Young, E.; Low, F. J.; Beichman, C. A.; Clegg, P. E.; Harris, S.; Rowan-Robinson, M.

    1984-01-01

    Observations from 12 to 100 microns are presented of two radio-quiet and three radio-loud quasars. Over this wavelength range, all five have grossly similar continuum energy distributions. The continua of the radio-loud quasars are consistent with synchrotron radiation. There is an indication, however, of excess 100 micron emission in the two radio-quiet quasars.

  9. The Traffic Noise Index: A Method of Controlling Noise Nuisance.

    Science.gov (United States)

    Langdon, F. J.; Scholes, W. E.

    This building research survey is an analysis of the social nuisance caused by urban motor ways and their noise. The Traffic Noise Index is used to indicate traffic noises and their effects on architectural designs and planning, while suggesting the need for more and better window insulation and acoustical barriers. Overall concern is for--(1)…

  10. Noise sensitivity and reactions to noise and other environmental conditions

    NARCIS (Netherlands)

    Miedema, H.M.E.; Vos, H.

    2003-01-01

    This article integrates findings from the literature and new results regarding noise sensitivity. The new results are based on analyses of 28 combined datasets (N=23 038), and separate analyses of a large aircraft noise study (N=10939). Three topics regarding noise sensitivity are discussed, namely,

  11. Evaluating noise abatement measures using strategic noise maps

    NARCIS (Netherlands)

    Borst, H.C.; Miedema, H.M.E.; Laan, W.P.N. van der; Lohman, W.J.A.

    2006-01-01

    Noise annoyance due to transportation is widespread in industrialized countries and in urban areas in the developing countries. The European Noise Directive (END) requires an assessment of the noise situation as well as the formulation of action plans for the reduction of the number of people

  12. Annoyance of low frequency noise and traffic noise

    DEFF Research Database (Denmark)

    Mortensen, F.R.; Poulsen, Torben

    2001-01-01

    The annoyance of different low frequency noise sources was determined and compared to the annoyance from traffic noise. Twenty-two subjects participated in laboratory listening tests. The sounds were presented by loudspeakers in a listening room and the spectra of the low frequency noises were...

  13. Rating environmental noise on the basis of noise maps

    NARCIS (Netherlands)

    Miedema, H.M.E.; Borst, H.C.

    2006-01-01

    A system that rates noise on the basis of noise maps has been developed which is based on empirical exposure-response relationships, so that effects in the community will be lower if the system gives a better rating. It is consistent with noise metrics and effect endpoint chosen in the EU, i.e., it

  14. Division B Commission 40: Radio Astronomy

    NARCIS (Netherlands)

    Chapman, Jessica M.; Giovaninni, Gabriele; Taylor, Russell; Carilli, Christopher; Hills, Richard; Hirabayashi, Hisashi; Jonas, Justin L.; Lazio, Joseph; Morganti, Raffaella; Nan, Rendong; Rubio, Monica; Shastri, Prjaval; Kellermann, Ken; Ekers, Ronald; Ohishi, Masatoshi

    2016-01-01

    IAU Commission 40 for Radio Astronomy (hereafter C40) brought together scientists and engineers who carry out observational and theoretical research in radio astronomy and who develop and operate the ground and space-based radio astronomy facilities and instrumentation. As of June 2015, the

  15. Exploring Community Radio Programming Practices to Inform ...

    African Journals Online (AJOL)

    A collective case study (multi-site) design was used to probe educational programming practices used in community radio. The paper explores how community radio station programming engages listeners in community generated education programmes that are produced through collaborative work with radio listener clubs.

  16. Politics and Radio in the 1924 Campaign.

    Science.gov (United States)

    Berkman, Dave

    1987-01-01

    Discusses the relation between radio broadcasting and politics in the 1924 presidential campaign, focusing on newspaper and magazine coverage. Notes radio's influence on candidate image, the aspect of censorship, and the use of radio during the campaign and after the election. (MM)

  17. Radio and γ -Ray Variability in the BL Lac PKS 0219−164: Detection of Quasi-periodic Oscillations in the Radio Light Curve

    Energy Technology Data Exchange (ETDEWEB)

    Bhatta, Gopal, E-mail: gopalbhatta716@gmail.com [Astronomical Observatory of the Jagiellonian University, ul. Orla 171, 30-244 Kraków (Poland); Mt. Suhora Observatory, Pedagogical University, ul. Podchorazych 2, 30-084 Kraków (Poland)

    2017-09-20

    In this work, we explore the long-term variability properties of the blazar PKS 0219−164 in the radio and the γ -ray regime, utilizing the OVRO 15 GHz and the Fermi /LAT observations from the period 2008–2017. We found that γ -ray emission is more variable than the radio emission implying that γ -ray emission possibly originated in more compact regions while the radio emission represented continuum emission from the large-scale jets. Also, in the γ -ray, the source exhibited spectral variability, characterized by the softer-when-brighter trend, a less frequently observed feature in the high-energy emission by BL Lacs. In radio, using Lomb–Scargle periodogram and weighted wavelet z -transform, we detected a strong signal of quasi-periodic oscillation (QPO) with a periodicity of 270 ± 26 days with possible harmonics of 550 ± 42 and 1150 ± 157 day periods. At a time when detections of QPOs in blazars are still under debate, the observed QPO with high statistical significance (∼97%–99% global significance over underlying red-noise processes) and persistent over nearly 10 oscillations could make one of the strongest cases for the detection of QPOs in blazar light curves. We discuss various blazar models that might lead to the γ -ray and radio variability, QPO, and the achromatic behavior seen in the high-energy emission from the source.

  18. Call Arrival Rate Prediction and Blocking Probability Estimation for Infrastructure based Mobile Cognitive Radio Personal Area Network

    Directory of Open Access Journals (Sweden)

    Neeta Nathani

    2017-08-01

    Full Text Available The Cognitive Radio usage has been estimated as non-emergency service with low volume traffic. Present work proposes an infrastructure based Cognitive Radio network and probability of success of CR traffic in licensed band. The Cognitive Radio nodes will form cluster. The cluster nodes will communicate on Industrial, Scientific and Medical band using IPv6 over Low-Power Wireless Personal Area Network based protocol from sensor to Gateway Cluster Head. For Cognitive Radio-Media Access Control protocol for Gateway to Cognitive Radio-Base Station communication, it will use vacant channels of licensed band. Standalone secondary users of Cognitive Radio Network shall be considered as a Gateway with one user. The Gateway will handle multi-channel multi radio for communication with Base Station. Cognitive Radio Network operators shall define various traffic data accumulation counters at Base Station for storing signal strength, Carrier-to-Interference and Noise Ratio, etc. parameters and record channel occupied/vacant status. The researches has been done so far using hour as interval is too long for parameters like holding time expressed in minutes and hence channel vacant/occupied status time is only probabilistically calculated. In the present work, an infrastructure based architecture has been proposed which polls channel status each minute in contrary to hourly polling of data. The Gateways of the Cognitive Radio Network shall monitor status of each Primary User periodically inside its working range and shall inform to Cognitive Radio- Base Station for preparation of minutewise database. For simulation, the occupancy data for all primary user channels were pulled in one minute interval from a live mobile network. Hourly traffic data and minutewise holding times has been analyzed to optimize the parameters of Seasonal Auto Regressive Integrated Moving Average prediction model. The blocking probability of an incoming Cognitive Radio call has been

  19. Noise-Induced Hearing Loss

    Science.gov (United States)

    ... Home » Health Info » Hearing, Ear Infections, and Deafness Noise-Induced Hearing Loss On this page: What is ... I find additional information about NIHL? What is noise-induced hearing loss? Every day, we experience sound ...

  20. Fast High-Quality Noise

    DEFF Research Database (Denmark)

    Frisvad, Jeppe Revall; Wyvill, Geoff

    2007-01-01

    At the moment the noise functions available in a graphics programmer's toolbox are either slow to compute or they involve grid-line artifacts making them of lower quality. In this paper we present a real-time noise computation with no grid-line artifacts or other regularity problems. In other words......, we put a new tool in the box that computes fast high-quality noise. In addition to being free of artifacts, the noise we present does not rely on tabulated data (everything is computed on the fly) and it is easy to adjust quality vs. quantity for the noise. The noise is based on point rendering (like...... spot noise), but it extends to more than two dimensions. The fact that it is based on point rendering makes art direction of the noise much easier....

  1. Spectral Characteristics of Pitot Noise

    Science.gov (United States)

    Hornung, H. G.; Parziale, N. J.

    For experimental studies of transition from laminar to turbulent boundary layer flow it is important to know the ambient noise spectrum in the facility. In supersonic wind tunnels this is often assessed by measuring pitot pressure noise.

  2. The Effect of Solar Radiation on Radio Signal for Radio Astronomy Purposes

    International Nuclear Information System (INIS)

    Nor Hazmin Sabri; Atiq Wahidah Azlan; Roslan Umar; Roslan Umar; Shahirah Syafa Sulan; Zainol Abidin Ibrahim; Wan Zul Adli Wan Mokhtar

    2015-01-01

    Radio astronomy is a subfields of astronomy which is discovers the celestial objects at radio frequencies. Observation in radio astronomy is conducted using single antenna or array of antennas, known as radio telescope. Other than that, radio astronomy also holds an advantage over other alternatives to optical astronomy due to its capability of observing from the ground level. In this study, the effect of solar radiation that contributes the Radio Frequency Interferences (RFI) is reviewed. The low RFI level is required to set up the radio telescope for radio astronomy observation. The effect of solar radiation on radio signal was investigated by determining the RFI pattern using spectrum analyzer. The solar radiation data was obtained from weather station located at KUSZA Observatory, East Coast Environmental Research Institute (ESERI), UniSZA. We can conclude that the solar radiation factor give the minimum significant effect to radio signal. (author)

  3. Vocal Noise Cancellation From Respiratory Sounds

    National Research Council Canada - National Science Library

    Moussavi, Zahra

    2001-01-01

    Although background noise cancellation for speech or electrocardiographic recording is well established, however when the background noise contains vocal noises and the main signal is a breath sound...

  4. Human-induced pluripotent stem cell-derived cardiomyocytes from cardiac progenitor cells: effects of selective ion channel blockade.

    Science.gov (United States)

    Altomare, Claudia; Pianezzi, Enea; Cervio, Elisabetta; Bolis, Sara; Biemmi, Vanessa; Benzoni, Patrizia; Camici, Giovanni G; Moccetti, Tiziano; Barile, Lucio; Vassalli, Giuseppe

    2016-12-01

    Human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes are likely to revolutionize electrophysiological approaches to arrhythmias. Recent evidence suggests the somatic cell origin of hiPSCs may influence their differentiation potential. Owing to their cardiomyogenic potential, cardiac-stromal progenitor cells (CPCs) are an interesting cellular source for generation of hiPSC-derived cardiomyocytes. The effect of ionic current blockade in hiPSC-derived cardiomyocytes generated from CPCs has not been characterized yet. Human-induced pluripotent stem cell-derived cardiomyocytes were generated from adult CPCs and skin fibroblasts from the same individuals. The effect of selective ionic current blockade on spontaneously beating hiPSC-derived cardiomyocytes was assessed using multi-electrode arrays. Cardiac-stromal progenitor cells could be reprogrammed into hiPSCs, then differentiated into hiPSC-derived cardiomyocytes. Human-induced pluripotent stem cell-derived cardiomyocytes of cardiac origin showed higher upregulation of cardiac-specific genes compared with those of fibroblastic origin. Human-induced pluripotent stem cell-derived cardiomyocytes of both somatic cell origins exhibited sensitivity to tetrodotoxin, a blocker of Na +  current (I Na ), nifedipine, a blocker of L-type Ca 2+  current (I CaL ), and E4031, a blocker of the rapid component of delayed rectifier K +  current (I Kr ). Human-induced pluripotent stem cell-derived cardiomyocytes of cardiac origin exhibited sensitivity to JNJ303, a blocker of the slow component of delayed rectifier K +  current (I Ks ). In hiPSC-derived cardiomyocytes of cardiac origin, I Na , I CaL , I Kr , and I Ks were present as tetrodotoxin-, nifedipine-, E4031-, and JNJ303-sensitive currents, respectively. Although cardiac differentiation efficiency was improved in hiPSCs of cardiac vs. non-cardiac origin, no major functional differences were observed between hiPSC-derived cardiomyocytes of different somatic

  5. Gene expression profile in human induced pluripotent stem cells: Chondrogenic differentiation in vitro, part A

    Science.gov (United States)

    Suchorska, Wiktoria Maria; Augustyniak, Ewelina; Richter, Magdalena; Trzeciak, Tomasz

    2017-01-01

    Human induced pluripotent stem cells (hiPSCs) offer promise in regenerative medicine, however more data are required to improve understanding of key aspects of the cell differentiation process, including how specific chondrogenic processes affect the gene expression profile of chondrocyte-like cells and the relative value of cell differentiation markers. The main aims of the present study were as follows: To determine the gene expression profile of chondrogenic-like cells derived from hiPSCs cultured in mediums conditioned with HC-402-05a cells or supplemented with transforming growth factor β3 (TGF-β3), and to assess the relative utility of the most commonly used chondrogenic markers as indicators of cell differentiation. These issues are relevant with regard to the use of human fibroblasts in the reprogramming process to obtain hiPSCs. Human fibroblasts are derived from the mesoderm and thus share a wide range of properties with chondrocytes, which also originate from the mesenchyme. Thus, the exclusion of dedifferentiation instead of chondrogenic differentiation is crucial. The hiPSCs were obtained from human primary dermal fibroblasts during a reprogramming process. Two methods, both involving embryoid bodies (EB), were used to obtain chondrocytes from the hiPSCs: EBs formed in a chondrogenic medium supplemented with TGF-β3 (10 ng/ml) and EBs formed in a medium conditioned with growth factors from HC-402-05a cells. Based on immunofluorescence and reverse transcription-quantiative polymerase chain reaction analysis, the results indicated that hiPSCs have the capacity for effective chondrogenic differentiation, in particular cells differentiated in the HC-402-05a-conditioned medium, which present morphological features and markers that are characteristic of mature human chondrocytes. By contrast, cells differentiated in the presence of TGF-β3 may demonstrate hypertrophic characteristics. Several genes [paired box 9, sex determining region Y-box (SOX) 5, SOX6

  6. Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor

    Directory of Open Access Journals (Sweden)

    Nora Freyer

    2016-08-01

    Full Text Available The hepatic differentiation of human induced pluripotent stem cells (hiPSC holds great potential for application in regenerative medicine, pharmacological drug screening, and toxicity testing. However, full maturation of hiPSC into functional hepatocytes has not yet been achieved. In this study, we investigated the potential of a dynamic three-dimensional (3D hollow fiber membrane bioreactor technology to improve the hepatic differentiation of hiPSC in comparison to static two-dimensional (2D cultures. A total of 100 × 106 hiPSC were seeded into each 3D bioreactor (n = 3. Differentiation into definitive endoderm (DE was induced by adding activin A, Wnt3a, and sodium butyrate to the culture medium. For further maturation, hepatocyte growth factor and oncostatin M were added. The same differentiation protocol was applied to hiPSC maintained in 2D cultures. Secretion of alpha-fetoprotein (AFP, a marker for DE, was significantly (p < 0.05 higher in 2D cultures, while secretion of albumin, a typical characteristic for mature hepatocytes, was higher after hepatic differentiation of hiPSC in 3D bioreactors. Functional analysis of multiple cytochrome P450 (CYP isoenzymes showed activity of CYP1A2, CYP2B6, and CYP3A4 in both groups, although at a lower level compared to primary human hepatocytes (PHH. CYP2B6 activities were significantly (p < 0.05 higher in 3D bioreactors compared with 2D cultures, which is in line with results from gene expression. Immunofluorescence staining showed that the majority of cells was positive for albumin, cytokeratin 18 (CK18, and hepatocyte nuclear factor 4-alpha (HNF4A at the end of the differentiation process. In addition, cytokeratin 19 (CK19 staining revealed the formation of bile duct-like structures in 3D bioreactors similar to native liver tissue. The results indicate a better maturation of hiPSC in the 3D bioreactor system compared to 2D cultures and emphasize the potential of dynamic 3D culture

  7. Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions.

    Science.gov (United States)

    Wang, Juan; Hao, Jie; Bai, Donghui; Gu, Qi; Han, Weifang; Wang, Lei; Tan, Yuanqing; Li, Xia; Xue, Ke; Han, Pencheng; Liu, Zhengxin; Jia, Yundan; Wu, Jun; Liu, Lei; Wang, Liu; Li, Wei; Liu, Zhonghua; Zhou, Qi

    2015-11-12

    Human induced pluripotent stem cells (hiPSCs) are considered as one of the most promising seed cell sources in regenerative medicine. Now hiPSC-based clinical trials are underway. To ensure clinical safety, cells used in clinical trials or therapies should be generated under GMP conditions, and with Xeno-free culture media to avoid possible side effects like immune rejection that induced by the Xeno reagents. However, up to now there are no reports for hiPSC lines developed completely under GMP conditions using Xeno-free reagents. Clinical-grade human foreskin fibroblast (HFF) cells used as feeder cells and parental cells of the clinical-grade hiPSCs were isolated from human foreskin tissues and cultured in Xeno-free media. Clinical-grade hiPSCs were derived by integration-free Sendai virus-based reprogramming kit in Xeno-free pluriton™ reprogramming medium or X medium. Neural cells and cardiomyocytes differentiation were conducted following a series of spatial and temporal specific signals induction according to the corresponding lineage development signals. Biological safety evaluation of the clinical-grade HFF cells and hiPSCs were conducted following the guidance of the "Pharmacopoeia of the People's Republic of China, Edition 2010, Volume III". We have successfully derived several integration-free clinical-grade hiPSC lines under GMP-controlled conditions and with Xeno-free reagents culture media in line with the current guidance of international and national evaluation criteria. As for the source of hiPSCs and feeder cells, biological safety evaluation of the HFF cells have been strictly reviewed by the National Institutes for Food and Drug Control (NIFDC). The hiPSC lines are pluripotent and have passed the safety evaluation. Moreover, one of the randomly selected hiPSC lines was capable of differentiating into functional neural cells and cardiomyocytes in Xeno-free culture media. The clinical-grade hiPSC lines therefore could be valuable sources for

  8. Evaluation of nefazodone-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sujeong, E-mail: crystalee@gmail.com [Next-generation Pharmaceutical Research Center, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 305-343 (Korea, Republic of); Lee, Hyang-Ae, E-mail: hyangaelee@gmail.com [Next-generation Pharmaceutical Research Center, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 305-343 (Korea, Republic of); Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 110-799 (Korea, Republic of); Human and Environmental Toxicology Program, University of Science and Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 305-350 (Korea, Republic of); Choi, Sung Woo, E-mail: djmaya@snu.ac.kr [Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 110-799 (Korea, Republic of); Kim, Sung Joon, E-mail: sjoonkim@snu.ac.kr [Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 110-799 (Korea, Republic of); Kim, Ki-Suk, E-mail: idkks00@gmail.com [Next-generation Pharmaceutical Research Center, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 305-343 (Korea, Republic of); Human and Environmental Toxicology Program, University of Science and Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 305-350 (Korea, Republic of)

    2016-04-01

    The recent establishment of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), which express the major cardiac ion channels and recapitulate spontaneous mechanical and electrical activities, may provide a possible solution for the lack of in vitro human-based cardiotoxicity testing models. Cardiotoxicity induced by the antidepressant nefazodone was previously revealed to cause an acquired QT prolongation by hERG channel blockade. To elucidate the cellular mechanisms underlying the cardiotoxicity of nefazodone beyond hERG, its effects on cardiac action potentials (APs) and ion channels were investigated using hiPSC-CMs with whole-cell patch clamp techniques. In a proof of principle study, we examined the effects of cardioactive channel blockers on the electrophysiological profile of hiPSC-CMs in advance of the evaluation of nefazodone. Nefazodone dose-dependently prolonged the AP duration at 90% (APD{sub 90}) and 50% (APD{sub 50}) repolarization, reduced the maximum upstroke velocity (dV/dt{sub max}) and induced early after depolarizations. Voltage-clamp studies of hiPSC-CMs revealed that nefazodone inhibited various voltage-gated ion channel currents including I{sub Kr}, I{sub Ks}, I{sub Na}, and I{sub Ca}. Among them, I{sub Kr} and I{sub Na} showed relatively higher sensitivity to nefazodone, consistent with the changes in the AP parameters. In summary, hiPSC-CMs enabled an integrated approach to evaluate the complex interactions of nefazodone with cardiac ion channels. These results suggest that hiPSC-CMs can be an effective model for detecting drug-induced arrhythmogenicity beyond the current standard assay of heterologously expressed hERG K{sup +} channels. - Highlights: • Nefazodone prolonged APD and decreased upstroke velocity of APs in hiPSC-CMs. • Nefazodone inhibited cardiac ion channels, especially I{sub Kr} and I{sub Na}, in hiPSC-CMs. • Nefazodone-induced AP changes are mainly the result of I{sub Kr} and I{sub Na} inhibition

  9. Accelerated differentiation of human induced pluripotent stem cells to blood-brain barrier endothelial cells.

    Science.gov (United States)

    Hollmann, Emma K; Bailey, Amanda K; Potharazu, Archit V; Neely, M Diana; Bowman, Aaron B; Lippmann, Ethan S

    2017-04-13

    Due to their ability to limitlessly proliferate and specialize into almost any cell type, human induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to generate human brain microvascular endothelial cells (BMECs), which compose the blood-brain barrier (BBB), for research purposes. Unfortunately, the time, expense, and expertise required to differentiate iPSCs to purified BMECs precludes their widespread use. Here, we report the use of a defined medium that accelerates the differentiation of iPSCs to BMECs while achieving comparable performance to BMECs produced by established methods. Induced pluripotent stem cells were seeded at defined densities and differentiated to BMECs using defined medium termed E6. Resultant purified BMEC phenotypes were assessed through trans-endothelial electrical resistance (TEER), fluorescein permeability, and P-glycoprotein and MRP family efflux transporter activity. Expression of endothelial markers and their signature tight junction proteins were confirmed using immunocytochemistry. The influence of co-culture with astrocytes and pericytes on purified BMECs was assessed via TEER measurements. The robustness of the differentiation method was confirmed across independent iPSC lines. The use of E6 medium, coupled with updated culture methods, reduced the differentiation time of iPSCs to BMECs from thirteen to 8 days. E6-derived BMECs expressed GLUT-1, claudin-5, occludin, PECAM-1, and VE-cadherin and consistently achieved TEER values exceeding 2500 Ω × cm 2 across multiple iPSC lines, with a maximum TEER value of 4678 ± 49 Ω × cm 2 and fluorescein permeability below 1.95 × 10 -7 cm/s. E6-derived BMECs maintained TEER above 1000 Ω × cm 2 for a minimum of 8 days and showed no statistical difference in efflux transporter activity compared to BMECs differentiated by conventional means. The method was also found to support long-term stability of BMECs harboring biallelic PARK2 mutations associated

  10. Application of Method of Variation to Analyze and Predict Human Induced Modifications of Water Resource Systems

    Science.gov (United States)

    Dessu, S. B.; Melesse, A. M.; Mahadev, B.; McClain, M.

    2010-12-01

    marginal benefit is maximized. Therefore, the variation model can help to predict the possible human induced modification of natural water system in order to gain the maximum productivity and benefit.

  11. Measurement of Noise in Supercapacitors

    OpenAIRE

    Szewczyk Arkadiusz

    2017-01-01

    A developed method and measurement setup for measurement of noise generated in a supercapacitor is presented. The requirements for noise data recording are considered and correlated with working modes of supercapacitors. An example of results of low-frequency noise measurements in commercially available supercapacitors are presented. The ability of flicker noise measurements suggests that they can be used to assess quality of tested supercapacitors.

  12. Measurement of Noise in Supercapacitors

    Directory of Open Access Journals (Sweden)

    Szewczyk Arkadiusz

    2017-12-01

    Full Text Available A developed method and measurement setup for measurement of noise generated in a supercapacitor is presented. The requirements for noise data recording are considered and correlated with working modes of supercapacitors. An example of results of low-frequency noise measurements in commercially available supercapacitors are presented. The ability of flicker noise measurements suggests that they can be used to assess quality of tested supercapacitors.

  13. Spectrum sensing algorithm based on autocorrelation energy in cognitive radio networks

    Science.gov (United States)

    Ren, Shengwei; Zhang, Li; Zhang, Shibing

    2016-10-01

    Cognitive radio networks have wide applications in the smart home, personal communications and other wireless communication. Spectrum sensing is the main challenge in cognitive radios. This paper proposes a new spectrum sensing algorithm which is based on the autocorrelation energy of signal received. By taking the autocorrelation energy of the received signal as the statistics of spectrum sensing, the effect of the channel noise on the detection performance is reduced. Simulation results show that the algorithm is effective and performs well in low signal-to-noise ratio. Compared with the maximum generalized eigenvalue detection (MGED) algorithm, function of covariance matrix based detection (FMD) algorithm and autocorrelation-based detection (AD) algorithm, the proposed algorithm has 2 11 dB advantage.

  14. HIGH-RESOLUTION IMAGING OF THE ATLBS REGIONS: THE RADIO SOURCE COUNTS

    Energy Technology Data Exchange (ETDEWEB)

    Thorat, K.; Subrahmanyan, R.; Saripalli, L.; Ekers, R. D., E-mail: kshitij@rri.res.in [Raman Research Institute, C. V. Raman Avenue, Sadashivanagar, Bangalore 560080 (India)

    2013-01-01

    The Australia Telescope Low-brightness Survey (ATLBS) regions have been mosaic imaged at a radio frequency of 1.4 GHz with 6'' angular resolution and 72 {mu}Jy beam{sup -1} rms noise. The images (centered at R.A. 00{sup h}35{sup m}00{sup s}, decl. -67 Degree-Sign 00'00'' and R.A. 00{sup h}59{sup m}17{sup s}, decl. -67 Degree-Sign 00'00'', J2000 epoch) cover 8.42 deg{sup 2} sky area and have no artifacts or imaging errors above the image thermal noise. Multi-resolution radio and optical r-band images (made using the 4 m CTIO Blanco telescope) were used to recognize multi-component sources and prepare a source list; the detection threshold was 0.38 mJy in a low-resolution radio image made with beam FWHM of 50''. Radio source counts in the flux density range 0.4-8.7 mJy are estimated, with corrections applied for noise bias, effective area correction, and resolution bias. The resolution bias is mitigated using low-resolution radio images, while effects of source confusion are removed by using high-resolution images for identifying blended sources. Below 1 mJy the ATLBS counts are systematically lower than the previous estimates. Showing no evidence for an upturn down to 0.4 mJy, they do not require any changes in the radio source population down to the limit of the survey. The work suggests that automated image analysis for counts may be dependent on the ability of the imaging to reproduce connecting emission with low surface brightness and on the ability of the algorithm to recognize sources, which may require that source finding algorithms effectively work with multi-resolution and multi-wavelength data. The work underscores the importance of using source lists-as opposed to component lists-and correcting for the noise bias in order to precisely estimate counts close to the image noise and determine the upturn at sub-mJy flux density.

  15. Fast Radio Bursts and Radio Transients from Black Hole Batteries

    OpenAIRE

    Mingarelli, Chiara M. F.; Levin, Janna; Lazio, T. Joseph W.

    2015-01-01

    Most black holes (BHs) will absorb a neutron star (NS) companion fully intact without tidal disruption, suggesting the pair will remain dark to telescopes. Even without tidal disruption, electromagnetic (EM) luminosity is generated from the battery phase of the binary when the BH interacts with the NS magnetic field. Originally, the luminosity was expected to be in high-energy X-rays or gamma-rays, however, we conjecture that some of the battery power is emitted in the radio bandwidth. While ...

  16. Aircraft Noise Reduction Subproject Overview

    Science.gov (United States)

    Fernandez, Hamilton; Nark, Douglas M.; Van Zante, Dale E.

    2016-01-01

    The material presents highlights of propulsion and airframe noise research being completed for the Advanced Air Transport Technology Project. The basis of noise reduction plans along with representative work for the airframe, propulsion, and propulsion-airframe integration is discussed for the Aircraft Noise reduction Subproject.

  17. The Signal Importance of Noise

    Science.gov (United States)

    Macy, Michael; Tsvetkova, Milena

    2015-01-01

    Noise is widely regarded as a residual category--the unexplained variance in a linear model or the random disturbance of a predictable pattern. Accordingly, formal models often impose the simplifying assumption that the world is noise-free and social dynamics are deterministic. Where noise is assigned causal importance, it is often assumed to be a…

  18. Background noise levels in Europe

    OpenAIRE

    Gjestland, Truls

    2008-01-01

    - This report gives a brief overview of typical background noise levels in Europe, and suggests a procedure for the prediction of background noise levels based on population density. A proposal for the production of background noise maps for Europe is included.

  19. Practical Ranges of Loudness Levels of Various Types of Environmental Noise, Including Traffic Noise, Aircraft Noise, and Industrial Noise

    Directory of Open Access Journals (Sweden)

    Sabine A. Janssen

    2011-05-01

    Full Text Available In environmental noise control one commonly employs the A-weighted sound level as an approximate measure of the effect of noise on people. A measure that is more closely related to direct human perception of noise is the loudness level. At constant A-weighted sound level, the loudness level of a noise signal varies considerably with the shape of the frequency spectrum of the noise signal. In particular the bandwidth of the spectrum has a large effect on the loudness level, due to the effect of critical bands in the human hearing system. The low-frequency content of the spectrum also has an effect on the loudness level. In this note the relation between loudness level and A-weighted sound level is analyzed for various environmental noise spectra, including spectra of traffic noise, aircraft noise, and industrial noise. From loudness levels calculated for these environmental noise spectra, diagrams are constructed that show the relation between loudness level, A‑weighted sound level, and shape of the spectrum. The diagrams show that the upper limits of the loudness level for broadband environmental noise spectra are about 20 to 40 phon higher than the lower limits for narrowband spectra, which correspond to the loudness levels of pure tones. The diagrams are useful for assessing limitations and potential improvements of environmental noise control methods and policy based on A-weighted sound levels.

  20. Practical ranges of loudness levels of various types of environmental noise, including traffic noise, aircraft noise, and industrial noise

    NARCIS (Netherlands)

    Salomons, E.M.; Janssen, S.A.

    2011-01-01

    In environmental noise control one commonly employs the A-weighted sound level as an approximate measure of the effect of noise on people. A measure that is more closely related to direct human perception of noise is the loudness level. At constant A-weighted sound level, the loudness level of a

  1. Chaos and noise.

    Science.gov (United States)

    He, Temple; Habib, Salman

    2013-09-01

    Simple dynamical systems--with a small number of degrees of freedom--can behave in a complex manner due to the presence of chaos. Such systems are most often (idealized) limiting cases of more realistic situations. Isolating a small number of dynamical degrees of freedom in a realistically coupled system generically yields reduced equations with terms that can have a stochastic interpretation. In situations where both noise and chaos can potentially exist, it is not immediately obvious how Lyapunov exponents, key to characterizing chaos, should be properly defined. In this paper, we show how to do this in a class of well-defined noise-driven dynamical systems, derived from an underlying Hamiltonian model.

  2. White noise on bialgebras

    CERN Document Server

    Schürmann, Michael

    1993-01-01

    Stochastic processes with independent increments on a group are generalized to the concept of "white noise" on a Hopf algebra or bialgebra. The main purpose of the book is the characterization of these processes as solutions of quantum stochastic differential equations in the sense of R.L. Hudsonand K.R. Parthasarathy. The notes are a contribution to quantum probability but they are also related to classical probability, quantum groups, and operator algebras. The Az ma martingales appear as examples of white noise on a Hopf algebra which is a deformation of the Heisenberg group. The book will be of interest to probabilists and quantum probabilists. Specialists in algebraic structures who are curious about the role of their concepts in probablility theory as well as quantum theory may find the book interesting. The reader should havesome knowledge of functional analysis, operator algebras, and probability theory.

  3. Radio halo sources in clusters of galaxies

    International Nuclear Information System (INIS)

    Hanisch, R.J.

    1986-01-01

    Radio halo sources remain one of the most enigmatic of all phenomena related to radio emission from galaxies in clusters. The morphology, extent, and spectral structure of these sources are not well known, and the models proposed to explain them suffer from this lack of observational detail. However, recent observations suggest that radio halo sources may be a composite of relic radio galaxies. The validity of this model could be tested using current and planned high resolutions, low-frequency radio telescopes. 31 references

  4. Radio investigations of clusters of galaxies

    International Nuclear Information System (INIS)

    Valentijn, E.A.

    1978-01-01

    This thesis contains a number of papers of the series entitled, A Westerbork Survey of Rich Clusters of Galaxies. The primary aim was to study the radio characteristics of cluster galaxies and especially the question whether their ''radio-activity'' is influenced by their location inside a cluster. It is enquired whether the presence of an intra-cluster medium (ICM), or the typical cluster evolution or cluster dynamical processes can give rise to radio-observable effects on the behaviour of cluster galaxies. 610 MHz WSRT observations of the Coma cluster (and radio observations of the Hercules supercluster) are presented. Extended radio sources in Abell clusters are then described. (Auth.)

  5. A search for fast radio bursts associated with gamma-ray bursts

    International Nuclear Information System (INIS)

    Palaniswamy, Divya; Wayth, Randall B.; Trott, Cathryn M.; Tingay, Steven J.; Reynolds, Cormac; McCallum, Jamie N.

    2014-01-01

    The detection of seven fast radio bursts (FRBs) has recently been reported. FRBs are short duration (∼1 ms), highly dispersed radio pulses from astronomical sources. The physical interpretation for the FRBs remains unclear but is thought to involve highly compact objects at cosmological distance. It has been suggested that a fraction of FRBs could be physically associated with gamma-ray bursts (GRBs). Recent radio observations of GRBs have reported the detection of two highly dispersed short duration radio pulses using a 12 m radio telescope at 1.4 GHz. Motivated by this result, we have performed a systematic and sensitive search for FRBs associated with GRBs. We have observed five GRBs at 2.3 GHz using a 26 m radio telescope located at the Mount Pleasant Radio Observatory, Hobart. The radio telescope was automated to rapidly respond to Gamma-ray Coordination Network notifications from the Swift satellite and slew to the GRB position within ∼140 s. The data were searched for pulses up to 5000 pc cm –3 in dispersion measure and pulse widths ranging from 640 μs to 25.60 ms. We did not detect any events ≥6σ. An in depth statistical analysis of our data shows that events detected above 5σ are consistent with thermal noise fluctuations only. A joint analysis of our data with previous experiments shows that previously claimed detections of FRBs from GRBs are unlikely to be astrophysical. Our results are in line with the lack of consistency noted between the recently presented FRB event rates and GRB event rates.

  6. Noise Phobia in Dog

    Directory of Open Access Journals (Sweden)

    Mangle

    Full Text Available Fear of thunderstorms and other forms of noise phobia are common problems in dogs. Administering medications along with changing the pet’s environment, and using behavior modification techniques can help ease the fear. Above all, do not give your pet any attention or reward when he is showing signs of fear; this will only reinforce the fearful behavior. [Veterinary World 2008; 1(11.000: 351-352

  7. Thermal noise engines

    OpenAIRE

    Kish, Laszlo B.

    2010-01-01

    Electrical heat engines driven by the Johnson-Nyquist noise of resistors are introduced. They utilize Coulomb's law and the fluctuation-dissipation theorem of statistical physics that is the reverse phenomenon of heat dissipation in a resistor. No steams, gases, liquids, photons, combustion, phase transition, or exhaust/pollution are present here. In these engines, instead of heat reservoirs, cylinders, pistons and valves, resistors, capacitors and switches are the building elements. For the ...

  8. Implementation of LTE SC-FDMA on the USRP2 Software Defined Radio Platform

    DEFF Research Database (Denmark)

    Jørgensen, Peter Bjørn; Hansen, Thomas Lundgaard; Sørensen, Troels Bundgaard

    2011-01-01

    In this paper we discuss the implementation of a Single Carrier Frequency Division Multiple Access (SC-FDMA) transceiver running over the Universal Software Radio Peripheral 2 (USRP2). SC-FDMA is the air interface which has been selected for the uplink in the latest Long Term Evolution (LTE....../s. Experimental results on the Bit Error Rate (BER) versus Signal-to-Noise Ratio (SNR) are presented and compared to theoretical and simulated performance....

  9. Dispersive detection of radio-frequency-dressed states

    Science.gov (United States)

    Jammi, Sindhu; Pyragius, Tadas; Bason, Mark G.; Florez, Hans Marin; Fernholz, Thomas

    2018-04-01

    We introduce a method to dispersively detect alkali-metal atoms in radio-frequency-dressed states. In particular, we use dressed detection to measure populations and population differences of atoms prepared in their clock states. Linear birefringence of the atomic medium enables atom number detection via polarization homodyning, a form of common path interferometry. In order to achieve low technical noise levels, we perform optical sideband detection after adiabatic transformation of bare states into dressed states. The balanced homodyne signal then oscillates independently of field fluctuations at twice the dressing frequency, thus allowing for robust, phase-locked detection that circumvents low-frequency noise. Using probe pulses of two optical frequencies, we can detect both clock states simultaneously and obtain population difference as well as the total atom number. The scheme also allows for difference measurements by direct subtraction of the homodyne signals at the balanced detector, which should technically enable quantum noise limited measurements with prospects for the preparation of spin squeezed states. The method extends to other Zeeman sublevels and can be employed in a range of atomic clock schemes, atom interferometers, and other experiments using dressed atoms.

  10. [The century of noise].

    Science.gov (United States)

    Pivato, Stefano

    2011-01-01

    When did, actually, "noise pollution" begin to coexist along with our daily life and activities and change our environmental natural sounds, which hadn't changed for centuries? Industrial revolution, first, and the introduction of new technologies later, introduced "noise" as one of the most relevant features that marked the development of progress. Later on, it became the distinctive characteristic of the XX century. The incessant rumble of industrial machinery, of weapons and cannons from the wars, the roar of cars in the streets and aeroplanes from the sky, the deafening sound of XX century music, as well as the shouting out of new political ideas suddenly invaded the new century. They became part of our daily life so much as almost to become a new lay religion of modernity. As the century proceeded towards economic boom, a "new noisy Man" complied with this change, becoming the anthropologic prototype who was able to adapt to the new style of life and even contribute to its expansion. All this finally allows, to day, a definition of the XX century as the "century of noise".

  11. Universal Majorana thermoelectric noise

    Science.gov (United States)

    Smirnov, Sergey

    2018-04-01

    Thermoelectric phenomena resulting from an interplay between particle flows induced by electric fields and temperature inhomogeneities are extremely insightful as a tool providing substantial knowledge about the microscopic structure of a given system. By tuning, e.g., parameters of a nanoscopic system coupled via tunneling mechanisms to two contacts, one may achieve various situations where the electric current induced by an external bias voltage competes with the electric current excited by the temperature difference of the two contacts. Even more exciting physics emerges when the system's electronic degrees freedom split to form Majorana fermions which make the thermoelectric dynamics universal. Here, we propose revealing these unique universal signatures of Majorana fermions in strongly nonequilibrium quantum dots via noise of the thermoelectric transport beyond linear response. It is demonstrated that whereas mean thermoelectric quantities are only universal at large-bias voltages, the noise of the electric current excited by an external bias voltage and the temperature difference of the contacts is universal at any bias voltage. We provide truly universal, i.e., independent of the system's parameters, thermoelectric ratios between nonlinear response coefficients of the noise and mean current at large-bias voltages where experiments may easily be performed to uniquely detect these truly universal Majorana thermoelectric signatures.

  12. Tinnitus and leisure noise.

    Science.gov (United States)

    Williams, Warwick; Carter, Lyndal

    2017-04-01

    To study the relationship of life-time noise exposure and experience of tinnitus. Audiometric measures included otoscopy, pure tone air- and bone-conduction hearing threshold levels (HTL) and otoacoustic emissions (OAEs). Participants completed questionnaires including demographic information, past hearing health, history of participation in loud leisure activities, and attitudes to noise. A representative sample (1435) of the young (11-35 years old) Australian population. Of the sample, 63% indicated they experienced tinnitus in some form. There was no correlation of tinnitus experience with HTL or OAE amplitudes. Although median octave band HTLs for those who experienced tinnitus "all the time" were slightly higher for those who did not, neither group exhibited HTLs outside clinically-normal values. Of those who experienced tinnitus a direct correlation was found between frequency of experience of tinnitus and increasing cumulative, life-time noise exposure. Those who experienced tinnitus were more likely to report noticing deterioration in their hearing ability over time and to report difficulty hearing in quiet and/or noisy situations. Experience of tinnitus was found throughout this young population but not associated with HTLs or variation in OAE amplitudes. Males experienced 'permanent' tinnitus at significantly greater rate than females.

  13. Precision Geodesy via Radio Interferometry.

    Science.gov (United States)

    Hinteregger, H F; Shapiro, I I; Robertson, D S; Knight, C A; Ergas, R A; Whitney, A R; Rogers, A E; Moran, J M; Clark, T A; Burke, B F

    1972-10-27

    Very-long-baseline interferometry experiments, involving observations of extragalactic radio sources, were performed in 1969 to determine the vector separations between antenna sites in Massachusetts and West Virginia. The 845.130-kilometer baseline was estimated from two separate experiments. The results agreed with each other to within 2 meters in all three components and with a special geodetic survey to within 2 meters in length; the differences in baseline direction as determined by the survey and by interferometry corresponded to discrepancies of about 5 meters. The experiments also yielded positions for nine extragalactic radio sources, most to within 1 arc second, and allowed the hydrogen maser clocks at the two sites to be synchronized a posteriori with an uncertainty of only a few nanoseconds.

  14. Exploring three faint source detections methods for aperture synthesis radio images

    Science.gov (United States)

    Peracaula, M.; Torrent, A.; Masias, M.; Lladó, X.; Freixenet, J.; Martí, J.; Sánchez-Sutil, J. R.; Muñoz-Arjonilla, A. J.; Paredes, J. M.

    2015-04-01

    Wide-field radio interferometric images often contain a large population of faint compact sources. Due to their low intensity/noise ratio, these objects can be easily missed by automated detection methods, which have been classically based on thresholding techniques after local noise estimation. The aim of this paper is to present and analyse the performance of several alternative or complementary techniques to thresholding. We compare three different algorithms to increase the detection rate of faint objects. The first technique consists of combining wavelet decomposition with local thresholding. The second technique is based on the structural behaviour of the neighbourhood of each pixel. Finally, the third algorithm uses local features extracted from a bank of filters and a boosting classifier to perform the detections. The methods' performances are evaluated using simulations and radio mosaics from the Giant Metrewave Radio Telescope and the Australia Telescope Compact Array. We show that the new methods perform better than well-known state of the art methods such as SEXTRACTOR, SAD and DUCHAMP at detecting faint sources of radio interferometric images.

  15. Antenna design and implementation for the future space Ultra-Long wavelength radio telescope

    Science.gov (United States)

    Chen, Linjie; Aminaei, Amin; Gurvits, Leonid I.; Wolt, Marc Klein; Pourshaghaghi, Hamid Reza; Yan, Yihua; Falcke, Heino

    2018-04-01

    In radio astronomy, the Ultra-Long Wavelengths (ULW) regime of longer than 10 m (frequencies below 30 MHz), remains the last virtually unexplored window of the celestial electromagnetic spectrum. The strength of the science case for extending radio astronomy into the ULW window is growing. However, the opaqueness of the Earth's ionosphere makes ULW observations by ground-based facilities practically impossible. Furthermore, the ULW spectrum is full of anthropogenic radio frequency interference (RFI). The only radical solution for both problems is in placing an ULW astronomy facility in space. We present a concept of a key element of a space-borne ULW array facility, an antenna that addresses radio astronomical specifications. A tripole-type antenna and amplifier are analysed as a solution for ULW implementation. A receiver system with a low power dissipation is discussed as well. The active antenna is optimized to operate at the noise level defined by the celestial emission in the frequency band 1 - 30 MHz. Field experiments with a prototype tripole antenna enabled estimates of the system noise temperature. They indicated that the proposed concept meets the requirements of a space-borne ULW array facility.

  16. Handbook for industrial noise control

    Science.gov (United States)

    The basic principles of sound, measuring techniques, and instrumentation associated with general purpose noise control are discussed. Means for identifying and characterizing a noise problem so that subsequent work may provide the most efficient and cost effective solution are outlined. A methodology for choosing appropriate noise control materials and the proper implementation of control procedures is detailed. The most significant NASA sponsored contributions to the state of the art development of optimum noise control technologies are described including cases in which aeroacoustics and related research have shed some light on ways of reducing noise generation at its source.

  17. Active control of the noise

    International Nuclear Information System (INIS)

    Rodriguez V, Luis Alfonso; Lopez Q, Jose German

    2001-01-01

    The problems of acoustic noise are more and more preponderant in the measure in that the amount of equipment and industrial machinery is increased such as fans, transformers, compressors etc. the use of devices passive mechanics for the reduction of the noise is effective and very appreciated because its effects embrace a wide range of acoustic frequency. However, to low frequencies, such devices become too big and expensive besides that present a tendency to do not effective. The control of active noise, CAN, using the electronic generation anti-noise, constitutes an interesting solution to the problem because their operation principle allows achieving an appreciable reduction of the noise by means of the use of compact devices. The traditional techniques for the control of acoustic noise like barriers and silenced to attenuate it, are classified as passive and their works has been accepted as norm as for the treatment of problems of noise it refers. Such techniques are considered in general very effective in the attenuation of noise of wide band. However, for low frequency, the required passive structures are too big and expensive; also, their effectiveness diminishes flagrantly, that which makes them impractical in many applications. The active suppression is profiled like a practical alternative for the reduction of acoustic noise. The idea in the active treatment of the noise it contemplates the use of a device electro-acoustic, like a speaker for example that it cancels to the noise by the generation of sounds of Same width and of contrary phase (anti-noise). The cancellation phenomenon is carried out when the ant-noise combines acoustically with the noise, what is in the cancellation of both sounds. The effectiveness of the cancellation of the primary source of noise depends on the precision with which the width and the phase of the generated ant-noise are controlled. The active control of noise, ANC (activates noise control), it is being investigated for

  18. Measurements techniques for transportation noise

    International Nuclear Information System (INIS)

    Brambilla, G.

    2001-01-01

    The noise from transport systems (roads, railways and aircraft) are increasing more and more both in space and in time and, therefore, they are still the major factor responsible for environmental noise pollution. The population exposed to transport noise is also increasing, and the corresponding health effects on people (i.e. annoyance and sleep disturbance) become more severe. Due to this current situation international and national legislation has been issued and implemented to reduce the harmful effects of such noise. This paper describes the techniques prescribed by recent Italian legislation to measure road, railway and aircraft noise. (author)

  19. Noise tolerant spatiotemporal chaos computing.

    Science.gov (United States)

    Kia, Behnam; Kia, Sarvenaz; Lindner, John F; Sinha, Sudeshna; Ditto, William L

    2014-12-01

    We introduce and design a noise tolerant chaos computing system based on a coupled map lattice (CML) and the noise reduction capabilities inherent in coupled dynamical systems. The resulting spatiotemporal chaos computing system is more robust to noise than a single map chaos computing system. In this CML based approach to computing, under the coupled dynamics, the local noise from different nodes of the lattice diffuses across the lattice, and it attenuates each other's effects, resulting in a system with less noise content and a more robust chaos computing architecture.

  20. GREEN BANK TELESCOPE AND SWIFT X-RAY TELESCOPE OBSERVATIONS OF THE GALACTIC CENTER RADIO MAGNETAR SGR J1745–2900

    Energy Technology Data Exchange (ETDEWEB)

    Lynch, Ryan S.; Archibald, Robert F.; Kaspi, Victoria M.; Scholz, Paul, E-mail: rlynch@physics.mcgill.ca [Department of Physics, McGill University, 3600 University Street, Montreal, Quebec, H3A 2T8 (Canada)

    2015-06-20

    We present results from eight months of Green Bank Telescope 8.7 GHz observations and nearly 18 months of Swift X-ray telescope observations of the radio magnetar SGR J1745–2900. We tracked the radio and X-ray flux density, polarization properties, profile evolution, rotation, and single-pulse behavior. We identified two main periods of activity. The first is characterized by approximately 5.5 months of relatively stable evolution in radio flux density, rotation, and profile shape, while in the second these properties varied substantially. Specifically, a third profile component emerged and the radio flux also became more variable. The single pulse properties also changed, most notably with a larger fraction of pulses with pulse widths ∼5–20 ms in the erratic state. Bright single pulses are well described by a log-normal energy distribution at low energies, but with an excess at high energies. The 2–10 keV flux decayed steadily since the initial X-ray outburst, while the radio flux remained stable to within ∼20% during the stable state. A joint pulsar timing analysis of the radio and X-ray data shows a level of timing noise unprecedented in a radio magnetar, though during the time covered by the radio data alone the timing noise was at a level similar to that observed in other radio magnetars. While SGR J1745–2900 is similar to other radio magnetars in many regards, it differs by having experienced a period of relative stability in the radio that now appears to have ended, while the X-ray properties evolved independently.

  1. A Q-band two-beam cryogenic receiver for the Tianma Radio Telescope

    Science.gov (United States)

    Zhong, Wei-Ye; Dong, Jian; Gou, Wei; Yu, Lin-Feng; Wang, Jin-Qing; Xia, Bo; Jiang, Wu; Liu, Cong; Zhang, Hui; Shi, Jun; Yin, Xiao-Xing; Shi, Sheng-Cai; Liu, Qing-Hui; Shen, Zhi-Qiang

    2018-04-01

    A Q-band two-beam cryogenic receiver for the Tianma Radio Telescope (TMRT) has been developed, and it uses the independently-developed key microwave and millimeter-wave components operating from 35 to 50GHz with a fractional bandwidth of 35%. The Q-band receiver consists of three parts: optics, cold unit assembly and warm unit assembly, and it can receive simultaneously the left-handed and right-handed circularly polarized waves. The cold unit assembly of each beam is composed of a feed horn, a noise injection coupler, a differential phase shifter, an orthomode transducer and two low-noise amplifiers, and it works at a temperature range near 20 K to greatly improve the detection sensitivity of the receiving system. The warm unit assembly includes four radio-frequency amplifiers, four radio-frequency high-pass filters, four waveguide biased mixers, four 4–12 GHz intermediate-frequency amplifiers and one 31–38 GHz frequency synthesizer. The measured Q-band four-channel receiver noise temperatures are roughly 30–40 K. In addition, the single-dish spectral line and international very long baseline interferometry (VLBI) observations between the TMRT and East Asia VLBI Network at the Q-band have been successfully carried out, demonstrating the advantages of the TMRT equipped with the state-of-the-art Q-band receiver.

  2. Recent radio studies of SNR

    International Nuclear Information System (INIS)

    Dickel, J.R.

    1983-01-01

    SNR can generally be recognized as extended sources of continuum radio emission with non-thermal spectra located near the galactic plane. The author describes the kinds of observations currently being obtained and what they tell us about the objects. The data include continuum observations which can reach resolutions of about 1 arcsec using aperture synthesis techniques and also spectral line observations of the interstellar matter being encountered by the remnants. (Auth.)

  3. Superconducting Radio-Frequency Cavities

    Science.gov (United States)

    Padamsee, Hasan S.

    2014-10-01

    Superconducting cavities have been operating routinely in a variety of accelerators with a range of demanding applications. With the success of completed projects, niobium cavities have become an enabling technology, offering upgrade paths for existing facilities and pushing frontier accelerators for nuclear physics, high-energy physics, materials science, and the life sciences. With continued progress in basic understanding of radio-frequency superconductivity, the performance of cavities has steadily improved to approach theoretical capabilities.

  4. Identification of southern radio sources

    International Nuclear Information System (INIS)

    Savage, A.; Bolton, J.G.; Wright, A.E.

    1976-01-01

    Identifications are suggested for 36 radio sources from the southern zones of the Parkes 2700 MHz survey, 28 with galaxies, six with confirmed and two with suggested quasi-stellar objects. The identifications were made from the ESO quick blue survey plates, the SRC IIIa-J deep survey plates and the Palomar sky survey prints. Accurate optical positions have also been measured for nine of the objects and for five previously suggested identifications. (author)

  5. LEP Radio Frequency Copper Cavity

    CERN Multimedia

    The pulse of a particle accelerator. 128 of these radio frequency cavities were positioned around CERN's 27-kilometre LEP ring to accelerate electrons and positrons. The acceleration was produced by microwave electric oscillations at 352 MHz. The electrons and positrons were grouped into bunches, like beads on a string, and the copper sphere at the top stored the microwave energy between the passage of individual bunches. This made for valuable energy savings as it reduced the heat generated in the cavity.

  6. Expanding radio astronomy in Africa

    International Nuclear Information System (INIS)

    Gaylard, M J

    2013-01-01

    The Square Kilometre Array (SKA) Organisation announced in May 2012 that its members had agreed on a dual site solution for the SKA [1]. South Africa's bid for hosting the SKA has caused a ramp up of radio astronomy in Africa. To develop technology towards the SKA, the South African SKA Project (SKA SA) built a protoype radio telescope in 2007, followed in 2010 the seven antenna Karoo Array Telescope (KAT-7). Next is the 64 antenna MeerKAT, which will merge into SKA Phase 1 in Africa. As SKA Phase 2 is intended to add a high resolution capability with baselines out to 3000 km, the SKA SA brought in partner countries in Africa to host outstations. South Africa has been working with the partners to build capacity to operate the SKA and to benefit from it. The SA Department of Science and Technology (DST) developed a proposal to establish radio telescopes in the partner countries to provide hands-on learning and a capability for Very Long Baseline Interferometry (VLBI) research. Redundant 30 m class satellite antennas are being incorporated in this project.

  7. Radio outbursts in extragalactic sources

    International Nuclear Information System (INIS)

    Kinzel, W.M.

    1989-01-01

    Three aspects of the flux density variability of extragalactic radio sources were examined: millimeter wavelength short timescale variability, the spectral evolution of outbursts, and whether the outbursts are periodically spaced. Observations of extragalactic radio sources were conducted using the Five College Radio Astronomy Observatory between January and June 1985 at 88.2 GHz and during June and July 1985 at 40.0 GHz. Many of the sources exhibited significant flux density variations during the observing span. In addition, the most rapid variations observed were comparable with those reported in previous works. Two sources, 0355+50 and OJ287, both exhibited outbursts whose rise and fall timescales were less than a month. An anomalous flux density dropout was observed in 3C446 and was interpreted as an occultation event. Data at five frequencies between 2.7 and 89.6 GHz from the Dent-Balonek monitoring program were used to investigate the spectral evolution of eight outbursts. Outburst profile fitting was used to deconvolve the individual outbursts from one another at each frequency. The fit profiles were used to generate multiple epoch spectra to investigate the evolution of the outbursts. A phase residual minimization method was used to examine four sources for periodic behavior

  8. Advances in solar radio astronomy

    Science.gov (United States)

    Kundu, M. R.

    1982-01-01

    The status of the observations and interpretations of the sun's radio emission covering the entire radio spectrum from millimeter wavelengths to hectometer and kilometer wavelengths is reviewed. Emphasis is given to the progress made in solar radio physics as a result of recent advances in plasma and radiation theory. It is noted that the capability now exists of observing the sun with a spatial resolution of approximately a second of arc and a temporal resolution of about a millisecond at centimeter wavelengths and of obtaining fast multifrequency two-dimensional pictures of the sun at meter and decameter wavelengths. A summary is given of the properties of nonflaring active regions at millimeter, centimeter, and meter-decameter wavelengths. The properties of centimeter wave bursts are discussed in connection with the high spatial resolution observations. The observations of the preflare build-up of an active region are reviewed. High spatial resolution observations (a few seconds of arc to approximately 1 arcsec) are discussed, with particular attention given to the one- and two-dimensional maps of centimeter-wavelength burst sources.

  9. Workshop on Radio Recombination Lines

    CERN Document Server

    1980-01-01

    Since their first detection 15 years ago, radio recombination lines from several elements have been observed in a wide variety of objects including HII regions, planetary nebulae, molecular clouds, the diffuse interstellar medium, and recently, other galaxies. The observations span almost the entire range from 0.1 to 100 GHz, and employ both single­ djsh and aperture synthesis techniques. The theory of radio recombination lines has also advanced strongly, to the point where it is perhaps one of the best-understood in astro­ physics. In a parallel development, it has become possible over the last decade to study these same highly-excited atoms in the laboratory; this work provides further confirmation of the theoretical framework. However there has been continuing controversy over the astrophysical interpre­ tation of radio recombination line observations, especially regarding the role of stimulated emission. A workshop was held in Ottawa on 24-25 August, 1979, bringing together many of the active scientist...

  10. Toward a mechanistic understanding of human-induced rapid environmental change: A case study linking energy development, avian nest predation, and predators

    Science.gov (United States)

    Hethcoat, Matthew G.; Chalfoun, Anna D.

    2015-01-01

    Demographic consequences of human-induced rapid environmental change (HIREC) have been widely documented for many populations. The mechanisms underlying such patterns, however, are rarely investigated and yet are critical to understand for effective conservation and management.

  11. The 136 MHz/400 MHz earth station antenna-noise temperature prediction program documentation for RAE-B

    Science.gov (United States)

    Chin, M.

    1972-01-01

    A simulation study to determine the 136 MHz and 400 MHz noise temperature of the ground network antennas which will track the RAE-B satellite during data transmission periods is described. Since the noise temperature of the antenna effectively sets the signal-to-noise ratio (SNR) of the received signal, a knowledge of SNR will be helpful in locating the optimum time windows for data transmission during low-noise periods. Antenna-noise temperatures at 136 MHz and 400 MHz will be predicted for selected earth-based ground stations which will support RAE-B. The antenna-noise temperature predictions will include the effects of galactic-brightness temperature, the sun, and the brightest radio stars. Predictions will cover the ten-month period from March 1, 1973 to December 31, 1973. The RAE-B mission will be expecially susceptible to SNR degradation during the two eclipses of the Sun occurring in this period.

  12. The 136 MHZ/400 MHz earth station antenna-noise temperature prediction program for RAE-B

    Science.gov (United States)

    Taylor, R. E.; Fee, J. J.; Chin, M.

    1972-01-01

    A simulation study was undertaken to determine the 136 MHz and 400 MHz noise temperature of the ground network antennas which will track the RAE-B satellite during data transmission periods. Since the noise temperature of the antenna effectively sets the signal-to-noise ratio of the received signal, a knowledge of SNR will be helpful in locating the optimum time windows for data transmission during low noise periods. Antenna noise temperatures will be predicted for selected earth-based ground stations which will support RAE-B. Telemetry data acquisition will be at 400 MHz; tracking support at 136 MHz will be provided by the Goddard Range and Range Rate (RARR) stations. The antenna-noise temperature predictions will include the effects of galactic-brightness temperature, the sun, and the brightest radio stars. Predictions will cover the ten-month period from March 1, 1973 to December 31, 1973.

  13. Theory And Working Of Noise And Vibration

    International Nuclear Information System (INIS)

    Jeong, Il Rok

    1988-09-01

    This book deals with theory of noise including physical property of noise like term and characteristic of sound, occurrence of sound, characteristic of noise pollution and main cause of occurrence of noise, technique of prevention of noise with noise reduction, construction guide for prevention of noise, and measure of interior noise. It also has the theory of vibration such as an introduction of vibration, and technology of prevention of vibration, official test method of environmental pollution, and summary of protection of the environment.

  14. Road traffic noise: self-reported noise annoyance versus GIS modelled road traffic noise exposure.

    Science.gov (United States)

    Birk, Matthias; Ivina, Olga; von Klot, Stephanie; Babisch, Wolfgang; Heinrich, Joachim

    2011-11-01

    self-reported road traffic noise annoyance is commonly used in epidemiological studies for assessment of potential health effects. Alternatively, some studies have used geographic information system (GIS) modelled exposure to road traffic noise as an objective parameter. The aim of this study was to analyse the association between noise exposure due to neighbouring road traffic and the noise annoyance of adults, taking other determinants into consideration. parents of 951 Munich children from the two German birth cohorts GINIplus and LISAplus reported their annoyance due to road traffic noise at home. GIS modelled road traffic noise exposure (L(den), maximum within a 50 m buffer) from the noise map of the city of Munich was available for all families. GIS-based calculated distance to the closest major road (≥10,000 vehicles per day) and questionnaire based-information about family income, parental education and the type of the street of residence were explored for their potential influence. An ordered logit regression model was applied. The noise levels (L(den)) and the reported noise annoyance were compared with an established exposure-response function. the correlation between noise annoyance and noise exposure (L(den)) was fair (Spearman correlation r(s) = 0.37). The distance to a major road and the type of street were strong predictors for the noise annoyance. The annoyance modelled by the established exposure-response function and that estimated by the ordered logit model were moderately associated (Pearson's correlation r(p) = 0.50). road traffic noise annoyance was associated with GIS modelled neighbouring road traffic noise exposure (L(den)). The distance to a major road and the type of street were additional explanatory factors of the noise annoyance appraisal.

  15. Effective Teacher Practice on the Plausibility of Human-Induced Climate Change

    Science.gov (United States)

    Niepold, F.; Sinatra, G. M.; Lombardi, D.

    2013-12-01

    Climate change education programs in the United States seek to promote a deeper understanding of the science of climate change, behavior change and stewardship, and support informed decision making by individuals, organizations, and institutions--all of which are summarized under the term 'climate literacy.' The ultimate goal of climate literacy is to enable actors to address climate change, both in terms of stabilizing and reducing emissions of greenhouse gases, but also an increased capacity to prepare for the consequences and opportunities of climate change. However, the long-term nature of climate change and the required societal response involve the changing students' ideas about controversial scientific issues which presents unique challenges for educators (Lombardi & Sinatra, 2010; Sinatra & Mason, 2008). This session will explore how the United States educational efforts focus on three distinct, but related, areas: the science of climate change, the human-climate interaction, and using climate education to promote informed decision making. Each of these approaches are represented in the Atlas of Science Literacy (American Association for the Advancement of Science, 2007) and in the conceptual framework for science education developed at the National Research Council (NRC) in 2012. Instruction to develop these fundamental thinking skills (e.g., critical evaluation and plausibility reappraisal) has been called for by the Next Generation Science Standards (NGSS) (Achieve, 2013), an innovative and research based way to address climate change education within the decentralized U.S. education system. However, the promise of the NGSS is that students will have more time to build mastery on the subjects, but the form of that instructional practice has been show to be critical. Research has show that effective instructional activities that promote evaluation of evidence improve students' understanding and acceptance toward the scientifically accepted model of human-induced

  16. Human induced prehistoric and historical soil erosion and landscape development in Southwestern USA

    Science.gov (United States)

    Dotterweich, Markus; Ivester, Andrew H.; Hanson, Paul R.; Daniel, Larsen; Dye, David H.; Foster, Thomas H., II

    2015-04-01

    gathered data will be used to i) compare the spatial extent of prehistoric and historic erosion and the short-term and long-term pedological and geomorphological effects of subtle soil erosion against extreme events, ii) assess the feedback-mechanisms of soil erosion on soil fertility and measurable land use changes in prehistorical and historical times, and (iii) estimate the long term effects of soil erosion and sediment deposition on archaeological features. The outcome will provide a decisive step forward to gather new qualitative and quantitative information on soil erosion during the Native American land use period to be able to achieve a better understanding of the long-term human induced landscape evolution in the uplands of the Southeastern USA and deliver data for a better predicting of landscape evolution to future climatic shifts in precipitation regimes.

  17. Sources of the Radio Background Considered

    Energy Technology Data Exchange (ETDEWEB)

    Singal, J.; /KIPAC, Menlo Park /Stanford U.; Stawarz, L.; /KIPAC, Menlo Park /Stanford U. /Jagiellonian U., Astron. Observ.; Lawrence, A.; /Edinburgh U., Inst. Astron. /KIPAC, Menlo Park /Stanford U.; Petrosian, V.; /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Stanford U., Appl. Phys. Dept.

    2011-08-22

    We investigate possible origins of the extragalactic radio background reported by the ARCADE 2 collaboration. The surface brightness of the background is several times higher than that which would result from currently observed radio sources. We consider contributions to the background from diffuse synchrotron emission from clusters and the intergalactic medium, previously unrecognized flux from low surface brightness regions of radio sources, and faint point sources below the flux limit of existing surveys. By examining radio source counts available in the literature, we conclude that most of the radio background is produced by radio point sources that dominate at sub {mu}Jy fluxes. We show that a truly diffuse background produced by elections far from galaxies is ruled out because such energetic electrons would overproduce the observed X-ray/{gamma}-ray background through inverse Compton scattering of the other photon fields. Unrecognized flux from low surface brightness regions of extended radio sources, or moderate flux sources missed entirely by radio source count surveys, cannot explain the bulk of the observed background, but may contribute as much as 10%. We consider both radio supernovae and radio quiet quasars as candidate sources for the background, and show that both fail to produce it at the observed level because of insufficient number of objects and total flux, although radio quiet quasars contribute at the level of at least a few percent. We conclude that the most important population for production of the background is likely ordinary starforming galaxies above redshift 1 characterized by an evolving radio far-infrared correlation, which increases toward the radio loud with redshift.

  18. Radio y cultura: una propuesta de radio ciudadana en Internet

    Directory of Open Access Journals (Sweden)

    Mauricio Andrés Álvarez-Moreno

    2015-01-01

    Full Text Available El presente artículo es resultado de la investigación para optar a título de magíster “La Peña Cultural: modelo de radio ciudadana en Internet”, realizada durante los años 2013 y 2014 para la Universidad de Medellín. En ella se realiza una exploración de la radio en Internet como plataforma con herramientas multimediales que podrían afianzar la formación de ciudadanía reflexiva por medio de contenidos de promoción cultural. De la misma manera, identifica, a partir de un rastreo de emisoras en Colombia, cómo esas herramientas –las redes sociales, podcasts, chats, canales de video y nuevas formas comunicativas– permiten la participación activa de los ciudadanos en su producción. Rescatar el uso de tecnologías que facilitan la comunicación, como la radio en Internet, para reconocer y recuperar el valor de la promoción cultural propia de un estado en aras de la formación de una ciudadanía reflexiva, es el acercamiento que se hizo a partir de la etnografía y la investigación aplicada y que ahora se expone en este artículo. Es la forma en que los ciudadanos podrían converger en un medio de comunicación para producir contenidos que fortalezcan su identidad cultural o, si se quiere, su visión de nación. Es la apuesta por establecer una alternativa a los ya tradicionales modelos, una guía para la comunidad interesada en promover una ciudadanía reflexiva del patrimonio cultural. Palabras clave

  19. FAST RADIO BURSTS AND RADIO TRANSIENTS FROM BLACK HOLE BATTERIES

    Energy Technology Data Exchange (ETDEWEB)

    Mingarelli, Chiara M. F. [TAPIR, MC 350-17, California Institute of Technology, Pasadena, CA 91125 (United States); Levin, Janna [Institute for Strings, Cosmology and Astroparticle Physics (ISCAP), Columbia University, New York, NY 10027 (United States); Lazio, T. Joseph W. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States)

    2015-12-01

    Most black holes (BHs) will absorb a neutron star (NS) companion fully intact without tidal disruption, suggesting the pair will remain dark to telescopes. Even without tidal disruption, electromagnetic (EM) luminosity is generated from the battery phase of the binary when the BH interacts with the NS magnetic field. Originally, the luminosity was expected to be in high-energy X-rays or gamma-rays, however, we conjecture that some of the battery power is emitted in the radio bandwidth. While the luminosity and timescale are suggestive of fast radio bursts (FRBs; millisecond-scale radio transients) NS–BH coalescence rates are too low to make these a primary FRB source. Instead, we propose that the transients form a FRB sub-population, distinguishable by a double peak with a precursor. The rapid ramp-up in luminosity manifests as a precursor to the burst which is 20%–80% as luminous given 0.5 ms timing resolution. The main burst arises from the peak luminosity before the merger. The post-merger burst follows from the NS magnetic field migration to the BH, causing a shock. NS–BH pairs are especially desirable for ground-based gravitational wave (GW) observatories since the pair might not otherwise be detected, with EM counterparts greatly augmenting the scientific leverage beyond the GW signal. The EM signal’s ability to break degeneracies in the parameters encoded in the GW and probe the NS magnetic field strength is quite valuable, yielding insights into open problems in NS magnetic field decay.

  20. FAST RADIO BURSTS AND RADIO TRANSIENTS FROM BLACK HOLE BATTERIES

    International Nuclear Information System (INIS)

    Mingarelli, Chiara M. F.; Levin, Janna; Lazio, T. Joseph W.

    2015-01-01

    Most black holes (BHs) will absorb a neutron star (NS) companion fully intact without tidal disruption, suggesting the pair will remain dark to telescopes. Even without tidal disruption, electromagnetic (EM) luminosity is generated from the battery phase of the binary when the BH interacts with the NS magnetic field. Originally, the luminosity was expected to be in high-energy X-rays or gamma-rays, however, we conjecture that some of the battery power is emitted in the radio bandwidth. While the luminosity and timescale are suggestive of fast radio bursts (FRBs; millisecond-scale radio transients) NS–BH coalescence rates are too low to make these a primary FRB source. Instead, we propose that the transients form a FRB sub-population, distinguishable by a double peak with a precursor. The rapid ramp-up in luminosity manifests as a precursor to the burst which is 20%–80% as luminous given 0.5 ms timing resolution. The main burst arises from the peak luminosity before the merger. The post-merger burst follows from the NS magnetic field migration to the BH, causing a shock. NS–BH pairs are especially desirable for ground-based gravitational wave (GW) observatories since the pair might not otherwise be detected, with EM counterparts greatly augmenting the scientific leverage beyond the GW signal. The EM signal’s ability to break degeneracies in the parameters encoded in the GW and probe the NS magnetic field strength is quite valuable, yielding insights into open problems in NS magnetic field decay

  1. Low noise constant current source for bias dependent noise measurements

    International Nuclear Information System (INIS)

    Talukdar, D.; Bose, Suvendu; Bardhan, K. K.; Chakraborty, R. K.

    2011-01-01

    A low noise constant current source used for measuring the 1/f noise in disordered systems in ohmic as well as nonohmic regime is described. The source can supply low noise constant current starting from as low as 1 μA to a few tens of milliampere with a high voltage compliance limit of around 20 V. The constant current source has several stages, which can work in a standalone manner or together to supply the desired value of load current. The noise contributed by the current source is very low in the entire current range. The fabrication of a low noise voltage preamplifier modified for bias dependent noise measurements and based on the existing design available in the MAT04 data sheet is also described.

  2. Noise hazard course

    CERN Multimedia

    2003-01-01

    A 1/2 day course to promote awareness of the risks incurred by noise at the work place and recommendations to settle them. Next course Wednesday 24th September 2003. Costs are covered by TIS, Jacques Coillard from Bureau Véritas will present the course. Registration is obligatory. For more information and to enrol on this course go to the safety section of Human Resources Training and Development web pages, or contact: Ana-Paula Bernardes/TIS-GS (71385) or e-mail Ana-Paula.Bernardes@cern.ch

  3. Noise hazard course

    CERN Multimedia

    2003-01-01

    A 1/2 day course to promote awareness of the risks incurred by noise at the work place and recommendations to settle them. Next course Wednesday 24th September 2003. Costs are covered by TIS, Jacques Coillard from Bureau Véritas will present the course. Registration is obligatory. For more information and to enrol on this course go to the safety section of Human Resources Training and Development web pages, or contact : Ana-Paula Bernardes/TIS-GS (71385) or e-mail Ana-Paula.Bernardes@cern.ch

  4. Generation of human induced pluripotent stem cells from urinary cells of a healthy donor using a non-integration system

    OpenAIRE

    Uhm, Kyung-Ok; Jo, Eun Hee; Go, Gue Youn; Kim, So-Jung; Choi, Hye Young; Im, Young Sam; Ha, Hye-Yeong; Jung, Ji-Won; Koo, Soo Kyung

    2017-01-01

    Urinary cells can be an ideal source for generating hiPSCs and progenitors, as they are easily accessible, non-invasive, and universally available. We generated human induced pluripotent stem cells (hiPSCs) from the urinary cells of a healthy donor using a Sendai virus-based gene delivery method. The generated hiPSC line, KSCBi001-A, has a normal karyotype (46,XY). The pluripotency and capacity of multilineage differentiation were characterized by comparison with those of a human embryonic st...

  5. Beneficial effect of human induced pluripotent stem cell-derived neural precursors in spinal cord injury repair

    Czech Academy of Sciences Publication Activity Database

    Romanyuk, Nataliya; Amemori, Takashi; Turnovcová, Karolína; Procházka, Pavel; Onteniente, B.; Syková, Eva; Jendelová, Pavla

    2015-01-01

    Roč. 24, č. 9 (2015), s. 1781-1797 ISSN 0963-6897 R&D Projects: GA MŠk LH12024; GA ČR(CZ) GA13-00939S; GA ČR(CZ) GBP304/12/G069; GA MŠk(CZ) ED1.1.00/02.0109; GA MŠk(CZ) LO1309 Institutional support: RVO:68378041 Keywords : human induced pluripotent stem cells * neural precursors * spinal cord injury Subject RIV: FH - Neurology Impact factor: 3.427, year: 2015

  6. Production and characterization of human induced pluripotent stem cells (iPSCs from Joubert Syndrome: CSSi001-A (2850

    Directory of Open Access Journals (Sweden)

    Jessica Rosati

    2018-03-01

    Full Text Available Joubert Syndrome (JS is a rare autosomal recessive or X-linked condition characterized by a peculiar cerebellar malformation, known as the molar tooth sign (MTS, associated with other neurological phenotypes and multiorgan involvement. JS is a ciliopathy, a spectrum of disorders whose causative genes encode proteins involved in the primary cilium apparatus. In order to elucidate ciliopathy-associated molecular mechanisms, human induced pluripotent stem cells (hiPSCs were derived from a patient affected by JS carrying a homozygous missense mutation in the AHI1 gene (p.H896R that encodes a protein named Jouberin.

  7. Background studies: human-induced effects on the evolution of shallow land burial sites for radioactive waste disposal

    International Nuclear Information System (INIS)

    1987-11-01

    This report presents the results of a programme of background research on the human-induced effects on the long term evolution of shallow disposal sites for low level radioactive wastes. The work is intended to support development and use of the TIME2 simulation code. Within the context of climatic change up to the next glacial maximum three areas are addressed: planning and legislative control over site usage, biosphere state changes and intrusion. An appendix presents a discussion of some planning aspects of radioactive waste disposal. (author)

  8. An overview and guide: planning instructional radio.

    Science.gov (United States)

    Imhoof, M

    1984-03-01

    Successful instructional radio projects require both comprehensive and complex planning. The instructional radio planning team needs to have knowledge and capabilities in several technical, social, and educational areas. Among other skills, the team must understand radio, curriculum design, the subject matter being taught, research and evaluation, and the environment in which the project operates. Once a basic approach to educational planning has been selected and broad educational goals set, radio may be selected as a cost effective means of achieving some of the goals. Assuming radio is a wise choice, there are still several factors which must be analyzed by a team member who is a radio specialist. The most obvious consideration is the inventory and evaluation of the facilities: studios; broadcast, recording, and transmission equipment; classroom radios; and so on. Capabilities of broadcast personnel are another consideration. Initial radio lessons need to teach the learners how to listen to the radio if they have no previous experience with institutional radio broadcasts. A captive, inschool audience ready to listen to radio instructions requires a different use of the medium than a noncaptive audience. With the noncaptive audience, the educational broadcaster must compete with entertaining choices from other media and popular activities and pastimes of the community. The most complex knowledge and analysis required in planning instructional radio concerns the relationship of the content to the medium. Environmental factors are important in planning educational programs. The physical environment may present several constraints on the learning experience and the use of radio. The most obvious is the effect of climate and terrain on the quality of radio reception. The physical environment is easily studied through experience in the target area, but this knowledge plays a significant role in designing effective learning materials for specific learners. Social

  9. Development of Active Noise Control System for Quieting Transformer Noise

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Bok Kyu; Song, Seik Young; Choi, Huo Yul [Korea Electric Power Research Institute, Taejon (Korea, Republic of); Yun, Dae Hea; Lee, Hyuk Jae [Korea Electrotechnology Research Institute, Changwon (Korea, Republic of)

    1997-12-31

    The passive noise control technique made use of sound-absorbing or soundproofing materials, so it required a large area and high cost for installation and had a drawback of poor performance at low frequency. Compared to this, the Active Noise Control attenuates noise sound pressure by using secondary source which has same performance ay low-frequency. Furthermore, it is able to save space and expenses. - research on adaptive algorithms - evaluation of global attenuation of the control - computer simulation - real-time Active Noise Control System Hardware Implementation - ANC system setting in the noisy area.

  10. Noise Estimation and Quality Assessment of Gaussian Noise Corrupted Images

    Science.gov (United States)

    Kamble, V. M.; Bhurchandi, K.

    2018-03-01

    Evaluating the exact quantity of noise present in an image and quality of an image in the absence of reference image is a challenging task. We propose a near perfect noise estimation method and a no reference image quality assessment method for images corrupted by Gaussian noise. The proposed methods obtain initial estimate of noise standard deviation present in an image using the median of wavelet transform coefficients and then obtains a near to exact estimate using curve fitting. The proposed noise estimation method provides the estimate of noise within average error of +/-4%. For quality assessment, this noise estimate is mapped to fit the Differential Mean Opinion Score (DMOS) using a nonlinear function. The proposed methods require minimum training and yields the noise estimate and image quality score. Images from Laboratory for image and Video Processing (LIVE) database and Computational Perception and Image Quality (CSIQ) database are used for validation of the proposed quality assessment method. Experimental results show that the performance of proposed quality assessment method is at par with the existing no reference image quality assessment metric for Gaussian noise corrupted images.

  11. Event reconstruction using the radio-interferometric technique in the frame of AERA

    Energy Technology Data Exchange (ETDEWEB)

    Rogozin, Dmytro [Institut fuer Experimentelle Kernphysik, Karlsruher Institut fuer Technologie (KIT) (Germany); Collaboration: Pierre-Auger-Collaboration

    2016-07-01

    It is a well-known fact that there is coherent radio emission induced by extensive air-showers. This fact is exploited in the Auger Engineering Radio Array (AERA), the radio extension of the Pierre Auger Observatory. This is a unique radio experiment due to its world-largest size of 17 km{sup 2}, and due to its precise nanosecond timing calibration. These features become crucial for detection of highly inclined air-showers with their very large foot-prints, and for the ability to apply interferometric reconstruction techniques. The standard reconstruction techniques typically treat all radio stations as separate detectors. Nevertheless there is a possibility to do an interferometric analysis. This means combining all detected signals from all antennas in a specific way. In this talk we present a beam-forming interferometric technique and its application to AERA. According to the definition of the beam-forming quantities one can expect its correlation with the shower parameters such as energy of the primary particle and distance to the shower maximum. At the first step, Monte-Carlo simulations of AERA events including the noise from measured events were used to test these dependencies. The results and the future perspectives of this method are discussed with a particular emphasis on very inclined air-showers where the aforementioned correlations are assumed to be strongest.

  12. Possible earthquake precursors revealed by LF radio signals

    Directory of Open Access Journals (Sweden)

    P. F. Biagi

    2001-01-01

    Full Text Available Among radio signals, low frequency (LF radio signals lie in the band between 30–300 kHz. Monitoring equipment with the ability to measure the electric strength of such signals at field sites, were designed and assembled in Italy. From 1993 onwards, the electric field strength of the MCO (216 kHz, France broadcasting station has been collecting measurements at two sites in central Italy that were chosen according to very low noise levels. At the end of 1996, radio signals from the CLT (189 kHz, Italy and CZE (270 kHz, Czech Republic broadcasting stations were included in the measurements. Meteorological data from central Italy were also collected over the same time period in order to study the influence of weather conditions on the experimental measurements. During the monitoring period, we observed some evident attenuation of the electric field strength in some of the radio signals at some of the receivers. The duration of the attenuation observed was several days, so it could possibly be related to particular meteorological conditions. On the other hand, this phenomenon might represent precursors of moderate (3.0 M 3.5 earthquakes that occurred near the receivers (within 50 km along the transmitter-receiver path. In this case, it is possible that the pre-seismic processes could have produced irregularities in the troposphere, such as ducts, reflecting layers and scattering zones, so that some local troposphere defocusing of the radio signals might have occurred. These observations were related only to moderate earthquakes and in these cases, suitable meteorological conditions were probably needed to observe the effect. Between February – March 1998, we observed at one measuring site, a significant increase in the CZE electric field strength. Unfortunately, we could not use the data of the other receiver in this case, due to frequent interruptions in the data set. The increase might have been a precursor of the strong seismic sequence (M = 5

  13. Gamma noise in CCDs

    International Nuclear Information System (INIS)

    Autio, G.W.; Bafico, M.A.

    1975-01-01

    The overall results indicated that charge coupled devices (CCD) used to read out detector signals or as signal processing electronics in future space sensors can operate real time in a high ionising radiation environment. Future work should be directed towards hardening the CCDs during the fabrication processes in order that they may survive total radiation doses up to 1 x 10 6 Rad (Si) and toward investigating ionising radiation effects in CCDs that are coupled with i.r. detectors. CCD devices employed to read out detector signals can be made capable of handling radiation induced excess noise and high false alarm rates generated in the detector elements. Ionising radiation effects induced in the detectors are expected to dominate those generated directly in the CCD readout structure; how much depends on the relative size of the detector. The low frequency γ induced excess noise measured in the CCD/MOSFET structure could cause problems for space sensors required to operate in real time only at the very high γ flux levels. Discrimination and circumvention techniques at the CCD ERO output are possible. γ pulses measured at the CCD ERO output were distributed in amplitude and exhibited variable pulse widths (some were many times a clock period). (author)

  14. The collective radio properties of symbiotic stars

    International Nuclear Information System (INIS)

    Seaquist, E.R.; Taylor, A.R.

    1990-01-01

    Radio measurements of symbiotic stars are reported which extend the search for radio emission and provide multifrequency and multiepoch measurements of previously detected stars. The results show no evidence that there are time variations in excess of about 30 percent over a period of several years in the detected stars. The radio flux densities are correlated with brightness in the IR, especially at the longer IR wavelengths where dust emission dominates. It is confirmed that symbiotics with the latest red giant spectral types are the most luminous radio emitters. The D-types are the most radio-luminous. Virtually all detected stars with measurements at more than one frequency exhibit a positive spectral index, consistent with optically thick thermal bremsstrahlung. The binary separation for a number of radio-emitting symbiotics is estimated, and it is found that the distribution of inferred binary separations is dramatically different for IR D-types than for S-types. 37 refs

  15. The Impact of Radio Interference on Future Radio Telescopes

    Science.gov (United States)

    Mitchell, Daniel A.; Robertson, Gordon J.; Sault, Robert J.

    While future radio telescopes will require technological advances from the communications industry interference from sources such as satellites and mobile phones is a serious concern. In addition to the fact that the level of interference is growing constantly the increased capabilities of next generation instruments make them more prone to harmful interference. These facilities must have mechanisms to allow operation in a crowded spectrum. In this report some of the factors which may limit the effectiveness of these mechanisms are investigated. Radio astronomy is unique among other observing wavelengths in that the radiation can be fully sampled at a rate which completely specifies the electromagnetic environment. Knowledge of phases and antennae gain factors affords one the opportunity to attempt to mitigate interference from the astronomical data. At present several interference mitigation techniques have been demonstrated to be extremely effective. However the observational scales of the new facilities will push the techniques to their limits. Processes such as signal decorrelation varying antenna gain and instabilities in the primary beam will have a serious effect on some of the algorithms. In addition the sheer volume of data produced will render some techniques computationally and financially impossible.

  16. Blind Recognition of Binary BCH Codes for Cognitive Radios

    Directory of Open Access Journals (Sweden)

    Jing Zhou

    2016-01-01

    Full Text Available A novel algorithm of blind recognition of Bose-Chaudhuri-Hocquenghem (BCH codes is proposed to solve the problem of Adaptive Coding and Modulation (ACM in cognitive radio systems. The recognition algorithm is based on soft decision situations. The code length is firstly estimated by comparing the Log-Likelihood Ratios (LLRs of the syndromes, which are obtained according to the minimum binary parity check matrixes of different primitive polynomials. After that, by comparing the LLRs of different minimum polynomials, the code roots and generator polynomial are reconstructed. When comparing with some previous approaches, our algorithm yields better performance even on very low Signal-Noise-Ratios (SNRs with lower calculation complexity. Simulation results show the efficiency of the proposed algorithm.

  17. Analysing Self Interference Cancellation in Full Duplex Radios

    DEFF Research Database (Denmark)

    Mahmood, Nurul Huda; Shafique Ansari, Imran; Berardinelli, Gilberto

    2016-01-01

    Full duplex communication promises a theoretical $100\\%$ throughput gain by doubling the number of simultaneous transmissions. Such compelling gains are conditioned on perfect cancellation of the self interference power resulting from simultaneous transmission and reception. Generally, self...... interference power is modelled as a noise-like constant level interference floor. However, experimental validations have shown that the self interference power is in practice a random variable depending on a number of factors such as the surrounding wireless environment and the degree of interference...... cancellation. In this study, we derive an analytical model for the residual self interference power, and demonstrate various applications of the derived model in analysing the performance of a Full Duplex radio. In general, full duplex communication is found to provide only modest throughput gains over half...

  18. PySE: Python Source Extractor for radio astronomical images

    Science.gov (United States)

    Spreeuw, Hanno; Swinbank, John; Molenaar, Gijs; Staley, Tim; Rol, Evert; Sanders, John; Scheers, Bart; Kuiack, Mark

    2018-05-01

    PySE finds and measures sources in radio telescope images. It is run with several options, such as the detection threshold (a multiple of the local noise), grid size, and the forced clean beam fit, followed by a list of input image files in standard FITS or CASA format. From these, PySe provides a list of found sources; information such as the calculated background image, source list in different formats (e.g. text, region files importable in DS9), and other data may be saved. PySe can be integrated into a pipeline; it was originally written as part of the LOFAR Transient Detection Pipeline (TraP, ascl:1412.011).

  19. Interplanetary fast shock diagnosis with the radio receiver on Ulysses

    Science.gov (United States)

    Hoang, S.; Pantellini, F.; Harvey, C. C.; Lacombe, C.; Mangeney, A.; Meuer-Vernet, N.; Perche, C.; Steinberg, J.-L.; Lengyel-Frey, D.; Macdowall, R. J.

    1992-01-01

    The radio receiver on Ulysses records the quasi-thermal noise which allows a determination of the density and temperature of the cold (core) electrons of the solar wind. Seven interplanetary fast forward or reverse shocks are identified from the density and temperature profiles, together with the magnetic field profile from the Magnetometer experiment. Upstream of the three strongest shocks, bursts of nonthermal waves are observed at the electron plasma frequency f(peu). The more perpendicular the shock, the longer the time interval during which these upstream bursts are observed. For one of the strongest shocks we also observe two kinds of upstream electromagnetic radiation: radiation at 2 f(peu), and radiation at the downstream electron plasma frequency, which propagates into the less dense upstream regions.

  20. Radio emission in peculiar galaxies

    Science.gov (United States)

    Demellorabaca, Dulia F.; Abraham, Zulema

    1990-01-01

    During the last decades a number of surveys of peculiar galaxies have been carried out and accurate positions become available. Since peculiarities are a possible evidence of radio emission (Wright, 1974; Sulentic, 1976; Stocke et al., 1978), the authors selected a sample of 24 peculiar galaxies with optical jet-like features or extensions in different optical catalogues, mainly the Catalogue of Southern Peculiar Galaxies and Associations (Arp and Madore, 1987) and the ESO/Uppsala Survey of the ESO(B) Atlas (Lauberts, 1982) for observation at the radio continuum frequency of 22 GHz. The sample is listed in a table. Sol (1987) studied this sample and concluded that the majority of the jet-like features seem to admit an explanation in terms of interactive galaxies with bridges and/or tails due to tidal effects. Only in a few cases do the jets seem to be possibly linked to some nuclear activity of the host galaxy. The observations were made with the 13.7m-radome enclosed Itapetinga Radiotelescope (HPBW of 4.3 arcmin), in Brazil. The receiver was a 1 GHz d.s.b. super-heterodine mixer operated in total-power mode, with a system temperature of approximately 800 K. The observational technique consisted in scans in right ascention, centralized in the optical position of the galaxy. The amplitude of one scan was 43 arcmin, and its duration time was 20 seconds. The integration time was at least 2 hours (12 ten-minute observations) and the sensibility limit adopted was an antenna temperature greater than 3 times the r.m.s. error of the baseline determination. Virgo A was used as the calibrator source. Three galaxies were detected for the first time as radio sources and four other known galaxies at low frequencies had their flux densities measured at 22 GHz. The results for these sources are presented.