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Sample records for human radiation experiments

  1. Human radiation experiments: Looking beyond the headlines

    International Nuclear Information System (INIS)

    Cohen, B.L.

    1994-01-01

    There has been a great deal of publicity recently about experiments supported by the U.S. Department of Energy and its predecessors, the Atomic Energy Commission (AEC) and the Energy Research and Development Administration, in which human subjects were exposed to radiation. Media stories give the impression that these experiments were done in secret, without informing the subjects, and that these subjects suffered horrible consequences. As a prelude to understanding the situation, it is useful to review the bases for judgement in deciding on this type of experiment. When it was first recognized that radiation can be harmful, national and international groups promulgated the concept of open-quotes maximum permissible doseclose quotes (MPD) on the basis that with a comfortable factor of safety (e.g., a factor of 10), there was no evidence of harm at that level. This had always been the principal method of providing safety, applied to everything from chemicals to bridges. In the 1940s, the MPD was 100 mrem per day, and it was assumed that there would be no harmful health impacts at that level. Current regulations require that experiments involving radiation exposure to human subjects be approved by a review board at the institution where they are carried out. National guidelines for these review boards require that whole-body doses to subjects be kept below 2 rem except in extraordinary circumstances. As an example of how these regulations are currently implemented, consider positron emission tomography (PET), a very active medical research topic for the past few years. In one major medical center, this involves exposing about 300 subjects per year, normally recruited through newspaper advertisements, with an average dose of about 400 mrem to each. There are about 50 comparable medical centers throughout the United States

  2. Interim report of the Advisory Committee on human radiation experiments

    Energy Technology Data Exchange (ETDEWEB)

    1994-10-21

    The Advisory Committee on Human Radiation Experiments was created by President Clinton to advise the Human Radiation Interagency Working Group on the ethical and scientific criteria applicable to human radiation experiments carried out or sponsored by the U.S. Government. The Committee seeks to answer several fundamental question: What ethics criteria should be used to evaluate human radiation experiments? What was the Federal Government`s role in human radiation experiments? What are the criteria for determining appropriate Federal responses where wrongs or harms have occurred? What lessons learned from studying past and present research standards and practices should be applied to the future? The Committee has been gathering vast amounts of information and working to render it orderly and accessible. In the next six months, the Committee will continue with the tasks of data gathering and organizing. The focus of the work, however, will be developing criteria for judging historical and contemporary experiments, policies, and procedures, as well as criteria for remedies that may be appropriate where harms or wrongs have ocurred. Based on findings, the Committee will make specific recommendations regarding policies for the future.

  3. Interim report of the Advisory Committee on human radiation experiments

    International Nuclear Information System (INIS)

    1994-01-01

    The Advisory Committee on Human Radiation Experiments was created by President Clinton to advise the Human Radiation Interagency Working Group on the ethical and scientific criteria applicable to human radiation experiments carried out or sponsored by the U.S. Government. The Committee seeks to answer several fundamental question: What ethics criteria should be used to evaluate human radiation experiments? What was the Federal Government's role in human radiation experiments? What are the criteria for determining appropriate Federal responses where wrongs or harms have occurred? What lessons learned from studying past and present research standards and practices should be applied to the future? The Committee has been gathering vast amounts of information and working to render it orderly and accessible. In the next six months, the Committee will continue with the tasks of data gathering and organizing. The focus of the work, however, will be developing criteria for judging historical and contemporary experiments, policies, and procedures, as well as criteria for remedies that may be appropriate where harms or wrongs have ocurred. Based on findings, the Committee will make specific recommendations regarding policies for the future

  4. Advisory Committee on human radiation experiments final report

    International Nuclear Information System (INIS)

    1995-10-01

    When the Advisory Committee began work in April 1994 we were charged with determining whether the radiation experiments design and administration adequately met the ethical and scientific standards, including standards of informed consent, that prevailed at the time of the experiments and that exist today and also to determine the ethical and scientific standards and criteria by which it shall evaluate human radiation experiments. Although this charge seems straightforward, it is in fact difficult to determine what the appropriate standards should be for evaluating the conduct and policies of thirty or fifty years ago. First, we needed to determine the extent to which the standards of that time are similar to the standards of today. To the extent that there were differences we needed to determine the relative roles of each in making moral evaluations. In Chapter 1 we report what we have been able to reconstruct about government rules and policies in the 1940s and 1950s regarding human experiments. We focus primarily on the Atomic Energy Commission and the Department of Defense. In Chapter 2 we turn from a consideration of government standards to an exploration of the norms and practices of physicians and medical scientists who conducted research with human subjects during this period. Using the results of our Ethics Oral History Project, and other sources, we also examine how scientists of the time viewed their moral responsibilities to human subjects as well as how this translated into the manner in which they conducted their research

  5. Advisory Committee on human radiation experiments final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    When the Advisory Committee began work in April 1994 we were charged with determining whether the radiation experiments design and administration adequately met the ethical and scientific standards, including standards of informed consent, that prevailed at the time of the experiments and that exist today and also to determine the ethical and scientific standards and criteria by which it shall evaluate human radiation experiments. Although this charge seems straightforward, it is in fact difficult to determine what the appropriate standards should be for evaluating the conduct and policies of thirty or fifty years ago. First, we needed to determine the extent to which the standards of that time are similar to the standards of today. To the extent that there were differences we needed to determine the relative roles of each in making moral evaluations. In Chapter 1 we report what we have been able to reconstruct about government rules and policies in the 1940s and 1950s regarding human experiments. We focus primarily on the Atomic Energy Commission and the Department of Defense. In Chapter 2 we turn from a consideration of government standards to an exploration of the norms and practices of physicians and medical scientists who conducted research with human subjects during this period. Using the results of our Ethics Oral History Project, and other sources, we also examine how scientists of the time viewed their moral responsibilities to human subjects as well as how this translated into the manner in which they conducted their research.

  6. Los Alamos Science: Number 23, 1995. Radiation protection and the human radiation experiments

    International Nuclear Information System (INIS)

    Cooper, N.G.

    1995-01-01

    There are a variety of myths and misconceptions about the ionizing radiation that surrounds and penetrates us all. Dispel a few of these by taking a leisurely tour of radiation and its properties, of the natural and man-made sources of ionizing radiation, and of the way doses are calculated. By damaging DNA and inducing genetic mutations, ionizing radiation can potentially initiate a cell on the road to cancer. The authors review what is currently known about regulation of cellular reproduction, DNA damage and repair, cellular defense mechanisms, and the specific cancer-causing genes that are susceptible to ionizing radiation. A rapid survey of the data on radiation effects in humans shows that high radiation doses increase the risk of cancer, whereas the effects of low doses are very difficult to detect. The hypothetical risks at low doses, which are estimated from the atomic-bomb survivors, are compared to the low-dose data so that the reader can assess the present level of uncertainty. As part of the openness initiative, ten individuals who have worked with plutonium during various periods in the Laboratory's history were asked to share their experiences including their accidental intakes. The history and prognosis of people who have had plutonium exposures is discussed by the Laboratory's leading epidemiologist

  7. Training of human resources on radiation protection and safe use of radiation sources. Argentine experience

    International Nuclear Information System (INIS)

    Biaggio, Alfredo L.; Nasazzi, Nora B.; Arias, Cesar

    2004-01-01

    Argentina has a long experience in Radiation Protection training since 25 years ago. In the present work we analyse those variable and non variable training aspects according to scientific development, increasing radiation source diversity (including new concepts like orphan sources and security), mayor concern about patient in Radiation Protection, previous exposures, etc. We comment what we consider the main steps in the training of Radiation Protection specialists, like university degree, post graduate education distinguishing between formative and informative contents and on the job training. Moreover, we point out the trainees aptitudes and attitudes to be developed in order to work properly in this interdisciplinary field. (author)

  8. Human radiation experiments associated with the US Department of Energy and its predecessors

    Energy Technology Data Exchange (ETDEWEB)

    None

    1995-07-01

    This document contains a listing, description, and selected references for documented human radiation experiments sponsored, supported, or performed by the US Department of Energy (DOE) or its predecessors, including the US Energy Research and Development Administration (ERDA), the US Atomic Energy Commission (AEC), the Manhattan Engineer District (MED), and the Off ice of Scientific Research and Development (OSRD). The list represents work completed by DOE`s Off ice of Human Radiation Experiments (OHRE) through June 1995. The experiment list is available on the Internet via a Home Page on the World Wide Web (http://www.ohre.doe.gov). The Home Page also includes the full text of Human Radiation Experiments. The Department of Energy Roadmap to the Story and the Records (DOE/EH-0445), published in February 1995, to which this publication is a supplement. This list includes experiments released at Secretary O`Leary`s June 1994 press conference, as well as additional studies identified during the 12 months that followed. Cross-references are provided for experiments originally released at the press conference; for experiments released as part of The DOE Roadmap; and for experiments published in the 1986 congressional report entitled American Nuclear Guinea Pigs: Three Decades of Radiation Experiments on US Citizens. An appendix of radiation terms is also provided.

  9. Advisory Committee on human radiation experiments. Supplemental Volume 2a, Sources and documentation appendices. Final report

    International Nuclear Information System (INIS)

    1995-01-01

    This large document provides a catalog of the location of large numbers of reports pertaining to the charge of the Presidential Advisory Committee on Human Radiation Research and is arranged as a series of appendices. Titles of the appendices are Appendix A- Records at the Washington National Records Center Reviewed in Whole or Part by DoD Personnel or Advisory Committee Staff; Appendix B- Brief Descriptions of Records Accessions in the Advisory Committee on Human Radiation Experiments (ACHRE) Research Document Collection; Appendix C- Bibliography of Secondary Sources Used by ACHRE; Appendix D- Brief Descriptions of Human Radiation Experiments Identified by ACHRE, and Indexes; Appendix E- Documents Cited in the ACHRE Final Report and other Separately Described Materials from the ACHRE Document Collection; Appendix F- Schedule of Advisory Committee Meetings and Meeting Documentation; and Appendix G- Technology Note

  10. Advisory Committee on human radiation experiments. Supplemental Volume 2a, Sources and documentation appendices. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-01-01

    This large document provides a catalog of the location of large numbers of reports pertaining to the charge of the Presidential Advisory Committee on Human Radiation Research and is arranged as a series of appendices. Titles of the appendices are Appendix A- Records at the Washington National Records Center Reviewed in Whole or Part by DoD Personnel or Advisory Committee Staff; Appendix B- Brief Descriptions of Records Accessions in the Advisory Committee on Human Radiation Experiments (ACHRE) Research Document Collection; Appendix C- Bibliography of Secondary Sources Used by ACHRE; Appendix D- Brief Descriptions of Human Radiation Experiments Identified by ACHRE, and Indexes; Appendix E- Documents Cited in the ACHRE Final Report and other Separately Described Materials from the ACHRE Document Collection; Appendix F- Schedule of Advisory Committee Meetings and Meeting Documentation; and Appendix G- Technology Note.

  11. Executive summary and guide to final report: Advisory committee on human radiation experiments

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-01-01

    On January 15, 1994, President Clinton appointed the Advisory Committee on Human Radiation Experiments to investigate reports of possibly unethical experiments funded by the government decades ago. The Committee was directed to uncover the history of human radiation experiments during the period 1944 through 1974 and to examine cases in which the government had intentionally released radiation into the environment for research purposes. The Committee was further charged with identifying the ethical and scientific standards for evaluating these events, and with making recommendations to ensure that whatever wrongdoing may have ocurred in the past cannot be repeated. The Committee undertook three projects: A review of how each agency of the federal government that currently conducts or funds research involving human subjects regulates this activity or oversees it; An examination of the documents and consent forms of research projects that are today sponsored by the federal government in order to develop insight into the current status of protections for the rights and interests of human subjects; and, Interviews of nearly 1,900 patients receiving out-patient medical care in private hospitals and federal facilities throughout the country. This booklet provides an overview of the Final Report, summarizing each chapter.

  12. Human radiation experiments: The Department of Energy roadmap to the story and the records

    International Nuclear Information System (INIS)

    1995-02-01

    The role of the US Government in conducting or sponsoring human radiation experiments has become the subject of public debate. Questions have been raised about the purpose, extent, and health consequences of these studies, and about how subjects were selected. The extent to which subjects provided informed consent is also under scrutiny. To respond to these questions, the Clinton administration has directed the US Department of Energy (DOE), along with other Federal agencies, to retrieve and inventory all records that document human radiation experiments. Many such records are now publicly available and will permit an open accounting and understanding of what took place. This report summarizes the Department's ongoing search for records about human radiation experiments. It is also a roadmap to the large universe of pertinent DOE information. DOE is working to instill greater openness--consistent with national security and other appropriate considerations--throughout its operations. A key aspect of this effort is opening DOE's historical records to independent research and analysis

  13. Human radiation experiments: The Department of Energy roadmap to the story and the records

    Energy Technology Data Exchange (ETDEWEB)

    1995-02-01

    The role of the US Government in conducting or sponsoring human radiation experiments has become the subject of public debate. Questions have been raised about the purpose, extent, and health consequences of these studies, and about how subjects were selected. The extent to which subjects provided informed consent is also under scrutiny. To respond to these questions, the Clinton administration has directed the US Department of Energy (DOE), along with other Federal agencies, to retrieve and inventory all records that document human radiation experiments. Many such records are now publicly available and will permit an open accounting and understanding of what took place. This report summarizes the Department`s ongoing search for records about human radiation experiments. It is also a roadmap to the large universe of pertinent DOE information. DOE is working to instill greater openness--consistent with national security and other appropriate considerations--throughout its operations. A key aspect of this effort is opening DOE`s historical records to independent research and analysis.

  14. Building public trust: Actions to respond to the report of the Advisory Committee on human radiation experiments

    International Nuclear Information System (INIS)

    1997-03-01

    Democratic government requires trust: people need to know and believe that the government is telling the truth. Without information about what the government is doing and why, citizens cannot exercise democratic control over government institutions. During his first year in office, President Clinton became concerned about reports that the government had conducted unethical secret human radiation experiments during the Cold War. To address this issue, in January 1994, President Clinton established the Advisory Committee on Human Radiation Experiments (ACHRE), chaired by bioethicist Dr. Ruth Faden of Johns Hopkins University. The President also directed all Federal agencies to search for records related to human subjects radiation research and provide them to the Advisory Committee. This report presents the Administration's actions to respond to the ACHRE's findings and recommendations

  15. Building public trust: Actions to respond to the report of the Advisory Committee on human radiation experiments

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    Democratic government requires trust: people need to know and believe that the government is telling the truth. Without information about what the government is doing and why, citizens cannot exercise democratic control over government institutions. During his first year in office, President Clinton became concerned about reports that the government had conducted unethical secret human radiation experiments during the Cold War. To address this issue, in January 1994, President Clinton established the Advisory Committee on Human Radiation Experiments (ACHRE), chaired by bioethicist Dr. Ruth Faden of Johns Hopkins University. The President also directed all Federal agencies to search for records related to human subjects radiation research and provide them to the Advisory Committee. This report presents the Administration`s actions to respond to the ACHRE`s findings and recommendations.

  16. The relationship of animal experiments in predicting the effects on intrauterine radiation effects in the human

    International Nuclear Information System (INIS)

    Brent, R.L.; Beckmann, D.A.; Jensh, R.P.; Thomas Jefferson Univ., Philadelphia, PA

    1986-01-01

    Although animal studies cannot be used to predict human disease, they can be utilized to study the mechanisms and the risk of radiation embryological effects reported in humans. The radiation embryological effects dealing with sterility, tumor development, life span studies and certain aspects of central nervous system functions cannot be so evaluated because of marked discordance in development or function between the rodent and human. It is important to recognize that, although the effects are markedly different, all stages of gestation have pathological effects following intrauterine radiation. There is no stage that will not be affected by 50 cGy: death in the preimplantation period; major malformations during early organogenesis; minor malformations during later organogenesis; histogenetic depletion, disorganization and cell depletion in midgestation; and cell depletion during the later part of gestation. The threshold dose for each of these effects is approximately 20 cGy, except during late gestation when permanent effects may not be produced at this low dose. All radiation embryological effects are multicellular phenomenona and, since it is unlikely that they are stochastic phenomena, the risks are not linearly related to radiation dose. The only exception may be the lethal effect produced on the first day of gestation. The present maximum permissible exposure of 0.5 cGy per years is appropriate for women of reproductive age exposed to radiation in the work place. Exposures from diagnostic radiation below 5 cGy present such a small or non-measurable risk, that counselors can support the continuation of wanted pregnancies. Inadvertant or medically necessary radiographic examinations present no greater concern whether in the first or second half of the menstrual cycle since pre-ovulation exposures or post-conception exposures before the first missed menstrual period of 5 cGy or less present a similar minimal risk. (orig.)

  17. Advisory Committee on human radiation experiments. Final report, Supplemental Volume 2. Sources and documentation

    International Nuclear Information System (INIS)

    1995-01-01

    This volume and its appendixes supplement the Advisory Committee's final report by reporting how we went about looking for information concerning human radiation experiments and intentional releases, a description of what we found and where we found it, and a finding aid for the information that we collected. This volume begins with an overview of federal records, including general descriptions of the types of records that have been useful and how the federal government handles these records. This is followed by an agency-by-agency account of the discovery process and descriptions of the records reviewed, together with instructions on how to obtain further information from those agencies. There is also a description of other sources of information that have been important, including institutional records, print resources, and nonprint media and interviews. The third part contains brief accounts of ACHRE's two major contemporary survey projects (these are described in greater detail in the final report and another supplemental volume) and other research activities. The final section describes how the ACHRE information-nation collections were managed and the records that ACHRE created in the course of its work; this constitutes a general finding aid for the materials deposited with the National Archives. The appendices provide brief references to federal records reviewed, descriptions of the accessions that comprise the ACHRE Research Document Collection, and descriptions of the documents selected for individual treatment. Also included are an account of the documentation available for ACHRE meetings, brief abstracts of the almost 4,000 experiments individually described by ACHRE staff, a full bibliography of secondary sources used, and other information

  18. Advisory Committee on human radiation experiments. Final report, Supplemental Volume 2. Sources and documentation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-01-01

    This volume and its appendixes supplement the Advisory Committee`s final report by reporting how we went about looking for information concerning human radiation experiments and intentional releases, a description of what we found and where we found it, and a finding aid for the information that we collected. This volume begins with an overview of federal records, including general descriptions of the types of records that have been useful and how the federal government handles these records. This is followed by an agency-by-agency account of the discovery process and descriptions of the records reviewed, together with instructions on how to obtain further information from those agencies. There is also a description of other sources of information that have been important, including institutional records, print resources, and nonprint media and interviews. The third part contains brief accounts of ACHRE`s two major contemporary survey projects (these are described in greater detail in the final report and another supplemental volume) and other research activities. The final section describes how the ACHRE information-nation collections were managed and the records that ACHRE created in the course of its work; this constitutes a general finding aid for the materials deposited with the National Archives. The appendices provide brief references to federal records reviewed, descriptions of the accessions that comprise the ACHRE Research Document Collection, and descriptions of the documents selected for individual treatment. Also included are an account of the documentation available for ACHRE meetings, brief abstracts of the almost 4,000 experiments individually described by ACHRE staff, a full bibliography of secondary sources used, and other information.

  19. Department of Defense Report on Search for Human Radiation Experiment Records, 1944 - 1994, Volume 2

    Science.gov (United States)

    1997-06-01

    subsequent survival of patients in stage IV hepatic coma Abstract: This study did not involve human exposure to ionizing radiation. Start Date...renal function; (2) euthyroid subjects with renal disease; (3) hyperthyroid patients; and (4) myxedema patients. Simultaneous determinations of the...30 October 1953 Number Title ACIR54000-B Renal function and 131-1 clearance in hyperthyroidism and myxedema From a presently undetermined date

  20. Radiation and environment. Study of uranium transfer to humans by the food chain: experiment design and first results

    International Nuclear Information System (INIS)

    Perez, G.; Guzman, F.; Garcia, F.; Rodriguez, O.; Arruda-Neto, J.D.T.; Manso, M.V.; Mesa, J.; Deppman, A.; Likhachev, V.P.; Pereira, J.W.; Helene, O.M.; Araujo, G.W.; Camargo, S.P.; Cestari, A.C.

    2000-01-01

    During years, scientific assessments had considered plants, animal and other living organism as part of the environment in which radionuclides become dispersed. They were further seen as resources which, when contaminated, may contribute to human radiation exposure since some plants and animals are elements of food chains and represent pathways for the transfer of radionuclides to humans. Today, the assessments are development reflected the generally accepted position that priority should be given to evaluating the potential consequences for humans, which are among the most radiosensitive mammalian species. The transfer of radioisotopes from food to humans is still a well debated issue, because experimental results are even scarce. As a contribution to this issue, the Linear Accelerator Laboratory of the Physics Institute at the Sao Paulo University jointed to other institute of Brazil and Cuba development a project for study of uranium in the food-chain: food-animal/vegetables-human. This project involves experimentation with mammalians (wistar rats and beagles dogs), fishes and vegetables, plus extrapolation to humans by means of the General Multiple-Compartments Model. The pilot experiments in animal and vegetables are well described in the paper. As first results were obtained the transfer coefficients of uranium to the organs of animals as a function of the uranium concentration present in the administered food and the transfer coefficients of uranium for each part of the plant, as function of both growing time and uranium concentration in the nutrients solution. With this data it would be possible to evaluate the uranium ingestion by humans from animal products and plants, given their dietary habits, to infer human absorption of uranium associated with prolonged intake of uranium contained in food and estimates the content of uranium transferred to humans organs, thus allowing the evaluation of internally localized doses and the radiobiological damage and

  1. Leukemia in humans following exposure to ionizing radiation. A summary of the findings in Hiroshima and Nagasaki and comparison with other human experience

    Energy Technology Data Exchange (ETDEWEB)

    Brill, A B; Tomonaga, Masanobu; Heyssel, R M

    1960-10-01

    A review of the Hiroshima-Nagasaki leukemia experience thirteen years after the atomic bomb explosion in those two cities, and comparisons with other collected series of leukemia cases following radiation has again demonstrated beyond reasonable doubt the leukemogenic effect of ionizing radiation on humans. In spite of the heterogeneity of the various study groups there are surprisingly consistent findings. An increased risk of leukemia following doses probably as low as 50 to 100 rads (air-entry dose) whole body radiation has been demonstrated. Above this dose the increase in incidence of leukemia may be related linearly to dose of radiation. When extrapolated to zero dose this line intersects the expected spontaneous incidence. In the lower range it is impossible to be certain regarding the presence or absence of a threshold. As in other series the acute lymphocytic variety of leukemia in the very young is most increased. Chronic granulocytic leukemia was seen most commonly among the Japanese in the older age groups. The predilection of the various types of leukemia for specific age groups does not appear to be markedly altered although possibly the incidence of chronic granulocytic leukemia has been shifted to younger ages. Males and children in the age group below ten appear to be most sensitive to induction of leukemia by irradiation. The increased occurrenc of leukemia in an irradiated population appears to start about eighteen months after the event. In Japan the increased risk has persisted for thirteen years with the time of maximum risk approximately four to eight years following radiation. 128 references, 2 figures, 14 tables.

  2. Experience with synchrotron radiation sources

    International Nuclear Information System (INIS)

    Krinsky, S.

    1987-01-01

    The development of synchrotron radiation sources is discussed, emphasizing characteristics important for x-ray microscopy. Bending magnets, wigglers and undulators are considered as sources of radiation. Operating experience at the national Synchrotron Light Source on the VUV and XRAY storage rings is reviewed, with particular consideration given to achieved current and lifetime, transverse bunch dimensions, and orbit stability. 6 refs., 3 figs

  3. Radiation: Basic life for human

    International Nuclear Information System (INIS)

    Wan Saffiey Wan Abdullah

    2009-01-01

    Basically, radiation is sources for everything in this world. From radiation, many reactions and activities can be done by organisms. The tree can do photosynthesis and at the same time can give oxygen to human and others. In Quran, radiation was mentioned almost 41 times and from that, 12 are preferred to sun, moon, and stars. Radiation can be classified into two groups, mechanical and electromagnetic. Mechanical radiations are produced from vibration process. For example, when we are talking, sound radiation will be produced from vibration of sounds box. The guitar will sounded when we pluck it. Generally, mechanical radiation needs medium for its propagation and the velocity of wave can change and it cannot propagate in vacuum states. Meanwhile, electromagnetic radiations are energy that emitted in wave produced by propagation of electrical charges. This will produce magnetic fields and then if these fields changed, electrical fields will produce. There are two types of radiation in human life, natural radiation and artificially radiation. Radiation can be applied in medical and defend sector. Radiation also can be misuse by some people that want it for other purpose in intention to do something wrong, such as in making bomb and others weapons. In Malaysia, there are one act to control the imports, exports, licensing, transferring and application of ionizing radiation but not for non-ionizing radiation. In future, laser radiations have their own potential to become one of the most important radiations in renewable energy sector, medical and defend.

  4. Experiences in Radiation Litigation

    International Nuclear Information System (INIS)

    Jose, D.E.

    2002-01-01

    Approximately 20 years ago three events in the United States caused a significant increase in lawsuits filed by persons who claimed to have been injured from exposure to ionizing radiation. I have had some involvement in each of them. One event was the lawsuit filed by Karen Silkwood against Kerr McGee arising out of plutonium that had been found in her home. The Silkwood story became a popular movie and sensitized radiation workers to alleged injury from work related exposures. I participated in the United States Department of Justice amicus brief to the United States Supreme Court and attended that oral argument in the Supreme Court. The second event was a series of litigations filed against the United States by persons who had either been soldiers at the above ground testing of nuclear weapons (the so called a tomic soldiers ) or had been residents living downwind from the place where the bombs were exploded (the so called d ownwinders ) . I was responsible for defending many of these lawsuits as an attorney in the United States Department of Justice. The third event was the accident at Three Mile Island. Thousands of lawsuits were filed by nearby residents. After I entered private practice, I worked on those cases for some years. These three events served to stimulate an increase in cases filed because persons believe that their current illness was caused by some prior exposure to radiation. Most recently I have been defending lawsuits filed by persons who once worked at commercial nuclear power plants and now have some type of cancer. Over these 20 years I have won about 30 cases involving about 50 plaintiffs. In none of these cases was it likely that the person's cancer was caused by his radiation exposure. In fact, the plaintiff's dose was generally less than the average person's lifetime dose from diagnostic x-rays. There is a way in this mixed field of law and science to develop basic rules by which the legal system can quite easily distinguish between a

  5. Virtual laboratory for radiation experiments

    International Nuclear Information System (INIS)

    Tiftikci, A.; Kocar, C.; Tombakoglu, M.

    2009-01-01

    Simulation of alpha, beta and gamma radiation detection and measurement experiments which are part of real nuclear physics laboratory courses was realized with Monte Carlo method and JAVA Programming Language. As being known, establishing this type of laboratories are very expensive. At the same time, highly radioactive sources used in some experiments carries risk for students and also for experimentalists. By taking into consideration of those problems, the aim of this study is to setup a virtual radiation laboratory with minimum cost and to speed up the training of radiation physics for students with no radiation risk. Software coded possesses the nature of radiation and radiation transport with the help of Monte Carlo method. In this software, experimental parameters can be changed manually by the user and experimental results can be followed synchronous in an MCA (Multi Channel Analyzer) or an SCA (Single Channel Analyzer). Results obtained in experiments can be analyzed by these MCA or SCA panels. Virtual radiation laboratory which is developed in this study with reliable results and unlimited experimentation capability seems as an useful educational material. Moreover, new type of experiments can be integrated to this software easily and as a result, virtual laboratory can be extended.

  6. Human radiation experimentation: a health physics perspective

    International Nuclear Information System (INIS)

    Kathren, R.L.

    1996-01-01

    This paper observes ethical human experimentation can be considered in terms of two basic principles or tests: informed, willing and knowledgeable subjects; and expectation of benefits. A number of human experiments are evaluated in terms of these principles, including a sixteenth century toxicology experiment, the deliberate exposure by an x-ray pioneer, and the plutonium injection cases of the 1940's. The following rational ethic is proposed for the practice of health physics with respect to human radiation experimentation: At all levels, the health physicist has a professional as well as personal obligation to ensure that proper human requirements, including proper informed consent and willing subjects, arc carried out with respect to human radiation experimentation, and must be convinced that the real or potential benefits to be derived from the experiment clearly exceed the potential detriment and risk. (author)

  7. Design experience: CRBRP radiation shielding

    International Nuclear Information System (INIS)

    Disney, R.K.; Chan, T.C.; Gallo, F.G.; Hedgecock, L.R.; McGinnis, C.A.; Wrights, G.N.

    1978-11-01

    The Clinch River Breeder Reactor Plant (CRBRP) is being designed as a fast breeder demonstration project in the U.S. Liquid Metal Fast Breeder Reactor (LMFBR) program. Radiation shielding design of the facility consists of a comprehensive design approach to assure compliance with design and government regulatory requirements. Studies conducted during the CRBRP design process involved the aspects of radiation shielding dealing with protection of components, systems, and personnel from radiation exposure. Achievement of feasible designs, while considering the mechanical, structural, nuclear, and thermal performance of the component or system, has required judicious trade-offs in radiation shielding performance. Specific design problems which have been addressed are in-vessel radial shielding to protect permanent core support structures, flux monitor system shielding to isolate flux monitoring systems for extraneous background sources, reactor vessel support shielding to allow personnel access to the closure head during full power operation, and primary heat transport system pipe chaseway shielding to limit intermediate heat transport system sodium system coolant activation. The shielding design solutions to these problems defined a need for prototypic or benchmark experiments to provide assurance of the predicted shielding performance of selected design solutions and the verification of design methodology. Design activities of CRBRP plant components an systems, which have the potential for radiation exposure of plant personnel during operation or maintenance, are controlled by a design review process related to radiation shielding. The program implements design objectives, design requirements, and cost/benefit guidelines to assure that radiation exposures will be ''as low as reasonably achievable''

  8. Radiation exposure and radiation hazards of human population. Pt. 1

    International Nuclear Information System (INIS)

    Jacobi, W.

    1982-01-01

    The present Part I provides a survey on the various sources of natural and artificial radiation exposure of human population. Furthermore, biological radiation effects and radiation damages are surveyed. In an appendix, radiation types, radiation doses, and radiation dose units are explained. (orig./GSCH) [de

  9. Radiation protection for human spaceflight

    International Nuclear Information System (INIS)

    Hajek, M.

    2009-01-01

    Cosmic radiation exposure is one of the most significant risks associated with human space exploration. Except for the principles of justification and optimization (ALARA), the concepts of terrestrial radiation protection are of limited applicability to human spaceflight, as until now only few experimentally verified data on the biological effectiveness of heavy ions and the dose distribution within the human body exist. Instead of applying the annual dose limits for workers on ground also to astronauts, whose careers are of comparatively short duration, the overall lifetime risk is used as a measure. For long-term missions outside Earth's magnetic field, the acceptable level of risk has not yet been defined, since there is not enough information available to estimate the risk of effects to the central nervous system and of potential non-cancer radiation health hazards. (orig.)

  10. Radiation and human health

    International Nuclear Information System (INIS)

    Sagan, L.

    1979-01-01

    The growing controversy over low-level radiation risks stems from challenges to the assumptions that had been made about dose rate, linear theory, and total-body exposure. The debate has focused on whether there is a risk threshold or whether linearity overstates low-level risks, both theories being consistent with the available data. The generally accepted consensus on the risks of cancer and genetic effects are examined for several occupational groups and compared with recent studies which use different methodologies and reach conflicting conclusions. The weaknesses of the more recent studies are noted and the conclusion is reached that adherence to the earlier assumptions is probably the conservative position. Since the relationship of exposure to small doses of carcinogenic agents to cancer is a weak link and difficult to verify statistically, the prognosis is poor for resolving the question of linearity. It is important that the costs of reducing the risks be carefully balanced with the available evidence

  11. Initial conditions of radiative shock experiments

    International Nuclear Information System (INIS)

    Kuranz, C. C.; Drake, R. P.; Krauland, C. M.; Marion, D. C.; Grosskopf, M. J.; Rutter, E.; Torralva, B.; Holloway, J. P.; Bingham, D.; Goh, J.; Boehly, T. R.; Sorce, A. T.

    2013-01-01

    We performed experiments at the Omega Laser Facility to characterize the initial, laser-driven state of a radiative shock experiment. These experiments aimed to measure the shock breakout time from a thin, laser-irradiated Be disk. The data are then used to inform a range of valid model parameters, such as electron flux limiter and polytropic γ, used when simulating radiative shock experiments using radiation hydrodynamics codes. The characterization experiment and the radiative shock experiment use a laser irradiance of ∼7 × 10 14 W cm −2 to launch a shock in the Be disk. A velocity interferometer and a streaked optical pyrometer were used to infer the amount of time for the shock to move through the Be disk. The experimental results were compared with simulation results from the Hyades code, which can be used to model the initial conditions of a radiative shock system using the CRASH code

  12. {sup 213}Bi-DOTATOC receptor-targeted alpha-radionuclide therapy induces remission in neuroendocrine tumours refractory to beta radiation: a first-in-human experience

    Energy Technology Data Exchange (ETDEWEB)

    Kratochwil, C.; Giesel, F.L.; Mier, W.; Haberkorn, U. [University Hospital Heidelberg, Department of Nuclear Medicine, Heidelberg (Germany); Bruchertseifer, F.; Apostolidis, C.; Morgenstern, A. [European Commission, Institute for Transuranium Elements, Karlsruhe (Germany); Boll, R.; Murphy, K. [Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    2014-11-15

    Radiopeptide therapy using a somatostatin analogue labelled with a beta emitter such as {sup 90}Y/{sup 177}Lu-DOTATOC is a new therapeutic option in neuroendocrine cancer. Alternative treatments for patients with refractory disease are rare. Here we report the first-in-human experience with {sup 213}Bi-DOTATOC targeted alpha therapy (TAT) in patients pretreated with beta emitters. Seven patients with progressive advanced neuroendocrine liver metastases refractory to treatment with {sup 90}Y/{sup 177}Lu-DOTATOC were treated with an intraarterial infusion of {sup 213}Bi-DOTATOC, and one patient with bone marrow carcinosis was treated with a systemic infusion of {sup 213}Bi-DOTATOC. Haematological, kidney and endocrine toxicities were assessed according to CTCAE criteria. Radiological response was assessed with contrast-enhanced MRI and {sup 68}Ga-DOTATOC-PET/CT. More than 2 years of follow-up were available in seven patients. The biodistribution of {sup 213}Bi-DOTATOC was evaluable with 440 keV gamma emission scans, and demonstrated specific tumour binding. Enduring responses were observed in all treated patients. Chronic kidney toxicity was moderate. Acute haematotoxicity was even less pronounced than with the preceding beta therapies. TAT can induce remission of tumours refractory to beta radiation with favourable acute and mid-term toxicity at therapeutic effective doses. (orig.)

  13. 213Bi-DOTATOC receptor-targeted alpha-radionuclide therapy induces remission in neuroendocrine tumours refractory to beta radiation: a first-in-human experience

    International Nuclear Information System (INIS)

    Kratochwil, C.; Giesel, F.L.; Mier, W.; Haberkorn, U.; Bruchertseifer, F.; Apostolidis, C.; Morgenstern, A.; Boll, R.; Murphy, K.

    2014-01-01

    Radiopeptide therapy using a somatostatin analogue labelled with a beta emitter such as 90 Y/ 177 Lu-DOTATOC is a new therapeutic option in neuroendocrine cancer. Alternative treatments for patients with refractory disease are rare. Here we report the first-in-human experience with 213 Bi-DOTATOC targeted alpha therapy (TAT) in patients pretreated with beta emitters. Seven patients with progressive advanced neuroendocrine liver metastases refractory to treatment with 90 Y/ 177 Lu-DOTATOC were treated with an intraarterial infusion of 213 Bi-DOTATOC, and one patient with bone marrow carcinosis was treated with a systemic infusion of 213 Bi-DOTATOC. Haematological, kidney and endocrine toxicities were assessed according to CTCAE criteria. Radiological response was assessed with contrast-enhanced MRI and 68 Ga-DOTATOC-PET/CT. More than 2 years of follow-up were available in seven patients. The biodistribution of 213 Bi-DOTATOC was evaluable with 440 keV gamma emission scans, and demonstrated specific tumour binding. Enduring responses were observed in all treated patients. Chronic kidney toxicity was moderate. Acute haematotoxicity was even less pronounced than with the preceding beta therapies. TAT can induce remission of tumours refractory to beta radiation with favourable acute and mid-term toxicity at therapeutic effective doses. (orig.)

  14. Solar radiation and human health

    International Nuclear Information System (INIS)

    Juzeniene, Asta; Moan, Kristin; Moan, Johan; Brekke, Paal; Dahlback, Arne; Andersson-Engels, Stefan; Reichrath, Joerg; Holick, Michael F; Grant, William B

    2011-01-01

    The Sun has played a major role in the development of life on Earth. In Western culture, people are warned against Sun exposure because of its adverse effects: erythema, photoimmunosuppression, photoageing, photocarcinogenesis, cataracts and photokeratitis. However, Sun exposure is also beneficial, since moderate doses give beneficial physiological effects: vitamin D synthesis, reduction of blood pressure and mental health. Shortage of Sun exposure may be even more dangerous to human health than excessive exposure. Avoiding Sun exposure leads to vitamin D deficiency which is associated not only with rickets and osteomalacia, but also with increased risk of cardiovascular disease, multiple sclerosis, rheumatoid arthritis, diabetes, influenza, many types of cancer and adverse pregnancy outcomes. Solar radiation induces nitric oxide release in tissue and immediate pigment darkening which certainly play important roles, although these are still unknown. Action spectra relevant for health are described. We will also review what is known about spectral and intensity variations of terrestrial solar radiation as well as its penetration through the atmosphere and into human skin and tissue.

  15. Solar radiation and human health

    Energy Technology Data Exchange (ETDEWEB)

    Juzeniene, Asta; Moan, Kristin; Moan, Johan [Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310 Oslo (Norway); Brekke, Paal [Norwegian Space Centre, PO Box 113, Skoeyen, N-0212 Oslo (Norway); Dahlback, Arne [Department of Physics, University of Oslo, Blindern, 0316 Oslo (Norway); Andersson-Engels, Stefan [Department of Physics, Lund University, PO Box 118, SE-221 00 Lund (Sweden); Reichrath, Joerg [Klinik fuer Dermatologie, Venerologie und Allergologie, Universitaetsklinikum des Saarlandes, D-66421 Homburg/Saar (Germany); Holick, Michael F [Department of Medicine, Section of Endocrinology, Nutrition and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, 85 E. Newton St., M-1013, Boston, MA 02118 (United States); Grant, William B, E-mail: asta.juzeniene@rr-research.no, E-mail: kmoan@hotmail.com, E-mail: paal.brekke@spacecentre.no, E-mail: arne.dahlback@fys.uio.no, E-mail: j.e.moan@fys.uio.no, E-mail: stefan.andersson-engels@fysik.lth.se, E-mail: joerg.reichrath@uks.eu, E-mail: mfholick@bu.edu, E-mail: wbgrant@infionline.net [Sunlight, Nutrition and Health Research Center (SUNARC), PO Box 641603, San Francisco, CA 94164-1603 (United States)

    2011-06-15

    The Sun has played a major role in the development of life on Earth. In Western culture, people are warned against Sun exposure because of its adverse effects: erythema, photoimmunosuppression, photoageing, photocarcinogenesis, cataracts and photokeratitis. However, Sun exposure is also beneficial, since moderate doses give beneficial physiological effects: vitamin D synthesis, reduction of blood pressure and mental health. Shortage of Sun exposure may be even more dangerous to human health than excessive exposure. Avoiding Sun exposure leads to vitamin D deficiency which is associated not only with rickets and osteomalacia, but also with increased risk of cardiovascular disease, multiple sclerosis, rheumatoid arthritis, diabetes, influenza, many types of cancer and adverse pregnancy outcomes. Solar radiation induces nitric oxide release in tissue and immediate pigment darkening which certainly play important roles, although these are still unknown. Action spectra relevant for health are described. We will also review what is known about spectral and intensity variations of terrestrial solar radiation as well as its penetration through the atmosphere and into human skin and tissue.

  16. Solar radiation and human health

    Science.gov (United States)

    Juzeniene, Asta; Brekke, Pål; Dahlback, Arne; Andersson-Engels, Stefan; Reichrath, Jörg; Moan, Kristin; Holick, Michael F.; Grant, William B.; Moan, Johan

    2011-06-01

    The Sun has played a major role in the development of life on Earth. In Western culture, people are warned against Sun exposure because of its adverse effects: erythema, photoimmunosuppression, photoageing, photocarcinogenesis, cataracts and photokeratitis. However, Sun exposure is also beneficial, since moderate doses give beneficial physiological effects: vitamin D synthesis, reduction of blood pressure and mental health. Shortage of Sun exposure may be even more dangerous to human health than excessive exposure. Avoiding Sun exposure leads to vitamin D deficiency which is associated not only with rickets and osteomalacia, but also with increased risk of cardiovascular disease, multiple sclerosis, rheumatoid arthritis, diabetes, influenza, many types of cancer and adverse pregnancy outcomes. Solar radiation induces nitric oxide release in tissue and immediate pigment darkening which certainly play important roles, although these are still unknown. Action spectra relevant for health are described. We will also review what is known about spectral and intensity variations of terrestrial solar radiation as well as its penetration through the atmosphere and into human skin and tissue.

  17. Radiation protection of non-human species

    International Nuclear Information System (INIS)

    Leith, I.S.

    1993-01-01

    The effects of radiation on non-human species, both animals and plants, have long been investigated. In the disposal of radioactive wastes, the protection of non-human species has been investigated. Yet no radiation protection standard for exposure of animals and plants per se has been agreed. The International Commission on Radiological Protection has long taken the view that, if human beings are properly protected from radiation, other species will thereby be protected to the extent necessary for their preservation. However, the International Atomic Energy Agency has found it necessary to investigate the protection of non-human species where radioactivity is released to an environment unpopulated by human beings. It is proposed that the basis of such protection, and the knowledge of radiation effects on non-human species on which it is based, suggest a practical radiation protection standard for non-human species. (1 tab.)

  18. SORCE: Solar Radiation and Climate Experiment

    Science.gov (United States)

    Cahalan, Robert; Rottman, Gary; Lau, William K. M. (Technical Monitor)

    2002-01-01

    Contents include the following: Understanding the Sun's influence on the Earth; How the Sun affect Earth's climate; By how much does the Sun's radiation very; Understanding Solar irradiance; History of Solar irradiance observations; The SORCE mission; How do the SORCE instruments measure solar radiation; Total irradiance monitor (TIM); Spectral irradiance monitor (SIM); Solar stellar irradiance comparison experiment (SOLSTICE); XUV photometer system (XPS).

  19. Radiations, human cancerization and radioresistance

    International Nuclear Information System (INIS)

    Vuillaume, M.

    1991-01-01

    Active oxygen species have been implicated in inflammatory diseases, cellular transformation and carcinogenesis. Experiments studying their direct (for instance, by ionizing radiation) or indirect influence (for instance, by the decrease(s) in activity of cellular defence enzymes), in vivo, and/or, in cell cultures (fibroblasts, keratinocytes, hepatocytes,...) have been positive. To the contrary, reactions or products, which decrease level(s) of free radicals/H 2 O 2 (i) directly, (ii) indirectly by an increase of SOD, catalase, and peroxydase activites suppress the above-described phenomena. This is the case for the domain number 2 (that contains copper, MW 53KDa) of the Scorpion's blood pigment (hemocyanin), which possesses SOD-, catalase-, and peroxydase-like properties, resistant to, at least, 4000 Gy, and thus may explain the especially high radioresistance of scorpions. Enzymatic decrease(s) and the domain number 2 of hemocyanin are under current investigation in several laboratories [fr

  20. A translatable predictor of human radiation exposure.

    Science.gov (United States)

    Lucas, Joseph; Dressman, Holly K; Suchindran, Sunil; Nakamura, Mai; Chao, Nelson J; Himburg, Heather; Minor, Kerry; Phillips, Gary; Ross, Joel; Abedi, Majid; Terbrueggen, Robert; Chute, John P

    2014-01-01

    Terrorism using radiological dirty bombs or improvised nuclear devices is recognized as a major threat to both public health and national security. In the event of a radiological or nuclear disaster, rapid and accurate biodosimetry of thousands of potentially affected individuals will be essential for effective medical management to occur. Currently, health care providers lack an accurate, high-throughput biodosimetric assay which is suitable for the triage of large numbers of radiation injury victims. Here, we describe the development of a biodosimetric assay based on the analysis of irradiated mice, ex vivo-irradiated human peripheral blood (PB) and humans treated with total body irradiation (TBI). Interestingly, a gene expression profile developed via analysis of murine PB radiation response alone was inaccurate in predicting human radiation injury. In contrast, generation of a gene expression profile which incorporated data from ex vivo irradiated human PB and human TBI patients yielded an 18-gene radiation classifier which was highly accurate at predicting human radiation status and discriminating medically relevant radiation dose levels in human samples. Although the patient population was relatively small, the accuracy of this classifier in discriminating radiation dose levels in human TBI patients was not substantially confounded by gender, diagnosis or prior exposure to chemotherapy. We have further incorporated genes from this human radiation signature into a rapid and high-throughput chemical ligation-dependent probe amplification assay (CLPA) which was able to discriminate radiation dose levels in a pilot study of ex vivo irradiated human blood and samples from human TBI patients. Our results illustrate the potential for translation of a human genetic signature for the diagnosis of human radiation exposure and suggest the basis for further testing of CLPA as a candidate biodosimetric assay.

  1. A translatable predictor of human radiation exposure.

    Directory of Open Access Journals (Sweden)

    Joseph Lucas

    Full Text Available Terrorism using radiological dirty bombs or improvised nuclear devices is recognized as a major threat to both public health and national security. In the event of a radiological or nuclear disaster, rapid and accurate biodosimetry of thousands of potentially affected individuals will be essential for effective medical management to occur. Currently, health care providers lack an accurate, high-throughput biodosimetric assay which is suitable for the triage of large numbers of radiation injury victims. Here, we describe the development of a biodosimetric assay based on the analysis of irradiated mice, ex vivo-irradiated human peripheral blood (PB and humans treated with total body irradiation (TBI. Interestingly, a gene expression profile developed via analysis of murine PB radiation response alone was inaccurate in predicting human radiation injury. In contrast, generation of a gene expression profile which incorporated data from ex vivo irradiated human PB and human TBI patients yielded an 18-gene radiation classifier which was highly accurate at predicting human radiation status and discriminating medically relevant radiation dose levels in human samples. Although the patient population was relatively small, the accuracy of this classifier in discriminating radiation dose levels in human TBI patients was not substantially confounded by gender, diagnosis or prior exposure to chemotherapy. We have further incorporated genes from this human radiation signature into a rapid and high-throughput chemical ligation-dependent probe amplification assay (CLPA which was able to discriminate radiation dose levels in a pilot study of ex vivo irradiated human blood and samples from human TBI patients. Our results illustrate the potential for translation of a human genetic signature for the diagnosis of human radiation exposure and suggest the basis for further testing of CLPA as a candidate biodosimetric assay.

  2. The Status of Radiation Damage Experiments

    International Nuclear Information System (INIS)

    Strachan, Denis M.; Scheele, Randall D.; Icenhower, Jonathan P.; Kozelisky, Anne E.; Sell, Richard L.; Legore, Virginia L.; Schaef, Herbert T.; O'Hara, Matthew J.; Brown, Christopher F.; Buchmiller, William C.

    2001-01-01

    Experiments have been on-going for about two years to determine the effects that radiation damage have on the physical and chemical properties of candidate titanate ceramics for the immobilization of plutonium. We summarize the results of these experiments in this document

  3. Watch on human experiments.

    Science.gov (United States)

    Budiansky, S

    The National Institutes of Health's Recombinant DNA Advisory Committee (RAC) has reaffirmed its role as reviewer of recombinant DNA research with human subjects and of any proposals to release recombinant organisms into the environment. Review is binding on recipients of federal research funds, and government agencies and industry have agreed to comply voluntarily with RAC guidelines. Activist Jeremy Rifkin protested against RAC's recent closing of a session to the public in order to discuss the planned release of frost-resistant bacteria into the environment by a private firm, and a proposal by the Uniformed Services University of the Health Sciences to reduce the required containment level for research involving the cloning of a gene that codes for a dysentery-causing toxin.

  4. Intrinsic radiation resistance in human chondrosarcoma cells

    International Nuclear Information System (INIS)

    Moussavi-Harami, Farid; Mollano, Anthony; Martin, James A.; Ayoob, Andrew; Domann, Frederick E.; Gitelis, Steven; Buckwalter, Joseph A.

    2006-01-01

    Human chondrosarcomas rarely respond to radiation treatment, limiting the options for eradication of these tumors. The basis of radiation resistance in chondrosarcomas remains obscure. In normal cells radiation induces DNA damage that leads to growth arrest or death. However, cells that lack cell cycle control mechanisms needed for these responses show intrinsic radiation resistance. In previous work, we identified immortalized human chondrosarcoma cell lines that lacked p16 ink4a , one of the major tumor suppressor proteins that regulate the cell cycle. We hypothesized that the absence of p16 ink4a contributes to the intrinsic radiation resistance of chondrosarcomas and that restoring p16 ink4a expression would increase their radiation sensitivity. To test this we determined the effects of ectopic p16 ink4a expression on chondrosarcoma cell resistance to low-dose γ-irradiation (1-5 Gy). p16 ink4a expression significantly increased radiation sensitivity in clonogenic assays. Apoptosis did not increase significantly with radiation and was unaffected by p16 ink4a transduction of chondrosarcoma cells, indicating that mitotic catastrophe, rather than programmed cell death, was the predominant radiation effect. These results support the hypothesis that p16 ink4a plays a role in the radiation resistance of chondrosarcoma cell lines and suggests that restoring p16 expression will improve the radiation sensitivity of human chondrosarcomas

  5. Atomic collision experiments using pulsed synchrotron radiation

    International Nuclear Information System (INIS)

    Arikawa, Tatsuo; Watanabe, Tsutomu.

    1982-01-01

    High intensity and continuous nature of the synchrotron radiation are the properties that are fundamentally important for studies of some atomic collision experiments, and many processes have been investigated by using these characteristics. However, so far the property that the radiation is highly polarized and pulsed in time has not been exploited significantly in atomic physics. As an example of the atomic processes relevant to such polarized and pulsed features of the synchrotron radiation, collisions involving optically-allowed excited atoms and molecules will be presented. (author)

  6. BWR radiation exposure--experience and projection

    International Nuclear Information System (INIS)

    Falk, C.F.; Wilkinson, C.D.; Hollander, W.R.

    1979-01-01

    The BWR/6 Mark III radiation exposures are projected to be about half of those of current average operating experience of 725 man-rem. These projections are said to be realistic and based on current achievements and not on promises of future development. The several BWRs operating with low primary system radiation levels are positive evidence that radiation sources can be reduced. Improvements have been made in reducing the maintenance times for the BWR/6, and further improvements can be made by further attention to cost-effective plant arrangement and layout during detail design to improve accessibility and maintainability of each system and component

  7. RADIATION PROTECTION FOR HUMAN SPACEFLIGHT

    OpenAIRE

    Hellweg, C.E.; Baumstark-Khan, C.; Berger, T.

    2017-01-01

    Space is a special workplace not only because of microgravity and the dependency on life support systems, but also owing to a constant considerable exposure to a natural radiation source, the cosmic radiation. Galactic cosmic rays (GCR) and solar cosmic radiation (SCR) are the primary sources of the radiation field in space. Whereas the GCR component comprises all particles from protons to heavy ions with energies up to 10¹¹ GeV, the SCR component ejected in Solar Energetic Particle events (S...

  8. Medical management of radiation burns - some experiences

    International Nuclear Information System (INIS)

    Iyer, G.K.

    2014-01-01

    Localized exposure resulting in radiation burns are serious injuries, seen not only in this country but all over the world. All of these injuries have resulted from accidents in Industrial Radiography (non-destructive testing). In our country all these injuries have occurred in the private sectors who handle these radiography sources. These sources can be of Iridium-192 or Cobalt-60. Some of these accidents have occurred involving trained radiographers but sometimes casual workers have been exposed. Skin is highly vulnerable to the external radiation exposure. Damage of varying extent can be seen following radiotherapy and accidents involving X- and gamma-ray sources. The reaction is related to the absorbed dose, which in turn is dependent upon the energy of radiation and weather it is particulate or electromagnetic radiation. Beta particles give up their energy within a short range and hence are more hazardous. Radiation burns develop slowly and blister formation occurs usually after 4 weeks. After exposure the skin response occurs in the form of transient erythema, fixed erythema, transepidermal burns, full thickness radiation burns and epilation. In radiation accidents, particularly those involving X-ray machines, the patients may not be aware of the time of accident and the dose may not be known in those circumstances. The medical management and treatment of such patients, therefore, has its own challenges. This talk will share some experiences on treatment of radiation injuries. (author)

  9. Solar Radiation and Climate Experiment (SORCE) Satellite

    Science.gov (United States)

    2003-01-01

    This is a close-up of the NASA-sponsored Solar Radiation and Climate Experiment (SORCE) Satellite. The SORCE mission, launched aboard a Pegasus rocket January 25, 2003, will provide state of the art measurements of incoming x-ray, ultraviolet, visible, near-infrared, and total solar radiation. Critical to studies of the Sun and its effect on our Earth system and mankind, SORCE will provide measurements that specifically address long-term climate change, natural variability and enhanced climate prediction, and atmospheric ozone and UV-B radiation. Orbiting around the Earth accumulating solar data, SORCE measures the Sun's output with the use of state-of-the-art radiometers, spectrometers, photodiodes, detectors, and bolo meters engineered into instruments mounted on a satellite observatory. SORCE is carrying 4 instruments: The Total Irradiance Monitor (TIM); the Solar Stellar Irradiance Comparison Experiment (SOLSTICE); the Spectral Irradiance Monitor (SIM); and the XUV Photometer System (XPS).

  10. Low temperature experiments in radiation biophysics

    International Nuclear Information System (INIS)

    Moan, J.

    1977-01-01

    The reasons for performing experiments in radiation biophysics at low temperatures, whereby electron spectra may be studied, are explained. The phenomenon of phosphorescence spectra observed in frozen aqueous solutions of tryptophan and adenosine is also described. Free radicals play an important part in biological radiation effects and may be studied by ESR spectroscopy. An ESR spectrum of T 1 bacteriophages irradiated dry at 130K is illustrated and discussed. Hydrogen atoms, which give lines on the spectrum, are believed to be those radiation products causing most biological damage in a dry system. Low temperature experiments are of great help in explaining the significance of direct and indirect effects. This is illustrated for the case of trypsin. (JIW)

  11. Radiation protection for human population

    International Nuclear Information System (INIS)

    Kenigsberg, Ya.Eh.; Bogdevich, I.M.; Rolevich, I.V.; Sharovarov, G.A.; Skurat, V.V.

    1997-01-01

    Are given the results of researches carried out in Belarus in 1996 on the following directions: study of features of formation of the population irradiation doze; definition of collective irradiation dozes of the population of Belarus for 10 years after the Chernobyl accident and forecast of risk of radiation induced diseases; study of influence of the radioactive contamination on agricultural ecosystems; development of technologies of manufacture on the contaminated soils of plant and cattle-breeding production and food products with the permissible contents of radionuclides in according to the requirements of radiation protection; development and perfection of complex technologies, ways and means of decontamination, processing and burial of radioactive wastes; development and substantiation of actions for increase of radiation security of the population of Belarus; development of combined system of an estimation on problems of radiation protection of the population living on contaminated territories

  12. Ionising radiation and the developing human brain

    International Nuclear Information System (INIS)

    Schull, W.J.

    1991-01-01

    This article reviews the effects of radiation exposure of the developing human brain. Much of the evidence has come from the prenatally exposed in Hiroshima and Nagasaki. The effects on development age, mental retardation, head size, neuromuscular performance, intelligence tests, school performance and the occurrence of convulsions are discussed. Other topics covered include the biological nature of the damage to the brain, risk estimates in human and problems in radiation protection. (UK)

  13. Radiation protection for human population

    International Nuclear Information System (INIS)

    Bogdevich, I.M.; Kenigsberg, Ya.Eh.; Minenko, V.F.; Mrochek, A.G.; Rolevich, I.V.; Skurat, V.V.; Sharovarov, G.A.

    1998-01-01

    The purpose of researches is development of methods and means of reduction of radiation risk caused by the Chernobyl accident consequences by means of decrease of both individual and collective dozes by realization of special protective measures. The reconstruction of average collective accumulated irradiation dozes of the inhabitants of the contaminated populated localities of Belarus is carried out; the forecast of development of radiation induced oncologic diseases is given. The laws of formation of annual irradiation dozes are investigated; the prevailing role of internal irradiation dozes in formation of total dose loadings is detected. On this basis a number of practical projects directed on creation of effective land tenure and decrease of radioactive contamination of agricultural production, as well as decontamination technologies and radioactive waste management are executed. Are given the results of researches carried out in Belarus in 1997 on the following directions: dose monitoring of the population, estimation and forecast of both collective irradiation dozes and risks of radiation induced diseases; development and optimization of a complex of measures for effective land use and decrease of radioactive contamination of agricultural production in order to reduce irradiation dozes of the population; development of complex technologies and means of decontamination, treatment and burial of radioactive wastes; development and ground of the measures for increase of radiation protection of the population of Belarus during of the reducing period after the Chernobyl accident; development of complex system of an estimation and decision-making on problems of radiation protection of the population living on contaminated territories

  14. Astronaut exposure to space radiation - Space Shuttle experience

    International Nuclear Information System (INIS)

    Atwell, W.

    1990-01-01

    Space Shuttle astronauts are exposed to both the trapped radiation and the galactic cosmic radiation environments. In addition, the sun periodically emits high-energy particles which could pose a serious threat to flight crews. NASA adheres to federal regulations and recommended exposure limits for radiation protection and has established a radiological health and risk assessment program. Using models of the space radiation environment, a Shuttle shielding model, and an anatomical human model, crew exposure estimates are made for each Shuttle flight. The various models are reviewed. Dosimeters are worn by each astronaut and are flown at several fixed locations to obtain inflight measurements. The dosimetry complement is discussed in detail. A comparison between the premission calculations and measurements is presented. Extrapolation of Shuttle experience to long-duration exposure is explored. 14 refs

  15. Radiation-induced instability of human genome

    International Nuclear Information System (INIS)

    Ryabchenko, N.N.; Demina, Eh.A.

    2014-01-01

    A brief review is dedicated to the phenomenon of radiation-induced genomic instability where the increased level of genomic changes in the offspring of irradiated cells is characteristic. Particular attention is paid to the problems of genomic instability induced by the low-dose radiation, role of the bystander effect in formation of radiation-induced instability, and its relationship with individual radiosensitivity. We believe that in accordance with the paradigm of modern radiobiology the increased human individual radiosensitivity can be formed due to the genome instability onset and is a significant risk factor for radiation-induced cancer

  16. Initial state radiation experiment at MAMI

    Energy Technology Data Exchange (ETDEWEB)

    Mihovilovič, M.; Merkel, H. [Institut für Kernphysik, Johannes Gutenberg-Universität Mainz, Johann-Joachim-Becher-Weg 45, 55128 Mainz (Germany); Collaboration: A1-Collaboration

    2013-11-07

    In an attempt to contribute further insight into the discrepancy between the Lamb shift and elastic scattering determinations of the proton charge radius, a new experiment at MAMI is underway, aimed at measuring proton form-factors at very low momentum transfers by using a new technique based on initial state radiation. This paper reports on first findings of the pilot measurement performed in 2010, whose main goal was to check the feasibility of the proposed experiment and to recognize and overcome potential obstacles before running the full experiment in 2013.

  17. Theory and Experiment on Radiative Shocks

    Science.gov (United States)

    Drake, R. Paul

    2005-07-01

    The current generation of high-energy-density research facilities has enabled the beginnings of experimental studies of radiation hydrodynamic systems, common in astrophysics but difficult to produce in the laboratory. Radiative shock experiments specifically have been a topic of increasing effort in recent years. Our group and collaborators [1] have emphasized the radiographic observation of structure in radiative shocks. These shocks have been produced on the Omega laser by driving a Be piston through Xenon at velocities above 100 km/s. The talk will summarize these experiments and their results. Interpreting these and other experiments is hampered by the limited range of assumptions used in published theories, and by the limitations in readily available simulation tools. This has motivated an examination of radiative shock theory [2]. The talk will summarize the key issues and present results for specific cases. [ 1 ] Gail Glendinning, Ted Perry, Bruce Remington, Jim Knauer, Tom Boehly, and other members of the NLUF Experimental Astrophysics Team. Publications: Reighard et al., Phys. Rev. Lett. submitted; Leibrandt, et al., Ap J., in press, Reighard et al., IFSA 03 Proceedings, Amer. Nucl. Soc. (2004). [2] Useful discussions with Dmitri Ryutov and Serge Bouquet. Supported by the NNSA programs via DOE Grants DE-FG52-03NA00064 and DE FG53 2005 NA26014

  18. Influence of ionizing radiation on human body

    Directory of Open Access Journals (Sweden)

    Zygmunt Zdrojewicz

    2016-06-01

    Full Text Available This article describes positive and negative aspects of ionizing radiation and its effects on human body. Being a part of various medical procedures in medicine, ionising radiation has become an important aspect for both medical practitioners and patients. Commonly used in treatment, diagnostics and interventional radiology, its medical usage follows numerous rules, designed to reduce excessive exposure to ionizing radiation. Its widespread use makes it extremely important to research and confirm effects of various doses of radiation on patients of all ages. Two scientific theories, explaining radiation effects on human organism, stand in contrast: commonly accepted LNT-hypothesis and yet to be proven hormesis theory. Despite the fact that the current radiation protection standards are based on the linear theory (LNT-hypothesis, the hormesis theory arouses more and more interest, and numerous attempts are made to prove its validity. Further research expanding the knowledge on radiation hormesis can change the face of the future. Perhaps such researches will open up new possibilities for the use of ionizing radiation, as well as enable the calculation of the optimal and personalised radiation dose for each patient, allowing us to find a new “golden mean”. The authors therefore are careful and believe that these methods have a large future, primarily patient’s good should however be kept in mind.

  19. Epidemiological studies on radiation carcinogenesis in human populations following acute exposure: nuclear explosions and medical radiation

    International Nuclear Information System (INIS)

    Fabrikant, J.I.

    1981-01-01

    The present review provides an understanding of our current knowledge of the carcinogenic effect of low-dose radiation in man, and surveys the epidemiological studies of human populations exposed to nuclear explosions and medical radiation. Discussion centers on the contributions of quantitative epidemiology to present knowledge, the reliability of the dose-incidence data, and those relevant epidemiological studies that provide the most useful information for risk estimation of cancer induction in man. Reference is made to dose-incidence relationships from laboratory animal experiments where they may obtain, for problems and difficulties in extrapolation from data obtained at high doses to low doses, and from animal data to the human situation. The paper describes the methods of application of such epidemiological data for estimation of excess risk of radiation-induced cancer in exposed human populations and discusses the strengths and limitations of epidemiology in guiding radiation protection philosophy and public health policy

  20. Radiation dose assessment in space missions. The MATROSHKA experiment

    International Nuclear Information System (INIS)

    Reitz, Guenther

    2010-01-01

    The exact determination of radiation dose in space is a demanding and challenging task. Since January 2004, the International Space Station is equipped with a human phantom which is a key part of the MATROSHKA Experiment. The phantom is furnished with thousands of radiation sensors for the measurement of depth dose distribution, which has enabled the organ dose calculation and has demonstrated that personal dosemeter at the body surface overestimates the effective dose during extra-vehicular activity by more than a factor two. The MATROSHKA results serve to benchmark models and have therefore a large impact on the extrapolation of models to outer space. (author)

  1. Human exposure to ultraviolet radiation

    International Nuclear Information System (INIS)

    Bernhardt, J.H.; Matthes, R.

    1987-01-01

    Ultraviolet radiation is that part of the electromagnetic spectrum located between the softest ionizing radiation and visible radiation. The lower limit of 100 nm is equivalent to photon energies of 12.4 eV, which corresponds approximately to the limit for the production of ionization in biologically important materials. A historical subdividing of the UV-region takes some of the biological effects into account. In this arrangement the range 400-315 nm, the so-called black light region, is called UV-A. In this wavelength region, fluorescence can be induced in many substances. UV-B covers the range 315-280 nm (the skin erythemal region). Most of the biologically active and potentially harmful UV from the sun reaching the surface of the earth is part of this spectral region. UV-C includes the radiation of wavelengths less than 280 nm (the germicidal region). It should be noted that this classification is somewhat arbitrary, and today it is more usual to evaluate the biological effectiveness of the whole UV-range from 200 to 400 nm

  2. Acoustic emission sensor radiation damage threshold experiment

    International Nuclear Information System (INIS)

    Beeson, K.M.; Pepper, C.E.

    1994-01-01

    Determination of the threshold for damage to acoustic emission sensors exposed to radiation is important in their application to leak detection in radioactive waste transport and storage. Proper response to system leaks is necessary to ensure the safe operation of these systems. A radiation impaired sensor could provide ''false negative or false positive'' indication of acoustic signals from leaks within the system. Research was carried out in the Radiochemical Technology Division at Oak Ridge National Laboratory to determine the beta/gamma radiation damage threshold for acoustic emission sensor systems. The individual system consisted of an acoustic sensor mounted with a two part epoxy onto a stainless steel waveguide. The systems were placed in an irradiation fixture and exposed to a Cobalt-60 source. After each irradiation, the sensors were recalibrated by Physical Acoustics Corporation. The results were compared to the initial calibrations performed prior to irradiation and a control group, not exposed to radiation, was used to validate the results. This experiment determines the radiation damage threshold of each acoustic sensor system and verifies its life expectancy, usefulness and reliability for many applications in radioactive environments

  3. Impact of environmental radiation on human health

    International Nuclear Information System (INIS)

    Shekhawat, Jyotsna

    2012-01-01

    A clean environment is essential for human health because the interaction between the environment and human health shows the complexity. Air pollution, less water quality, noise etc directly affects the health. Climate change, depletion of ozone layer, loss of biodiversity and degradation of land can also affect human health. Most of the modern technologies produce radiations in the environment having both beneficial and harmful effects through radioactive material. Natural radioactive sources include Cosmic radiation comes from the sun and outer space is absorbed by the atmosphere, a small amount reaches the earth's surface to which we are exposed. The exposure to this type of radiation is higher for people living above sea level. Radon is produced through the decay of uranium and thorium that are found naturally in the earth's crust. Primordial and terrestrial radiation are present in rocks and soils and occur when naturally radioactive isotopes of uranium, thorium and potassium decay within the earth's crust. Artificial (or man-made) radioactive sources include Fallout radiation, which results from past atmospheric nuclear bomb tests (1950s and 1960s many test explosions). Each environmental change, whether occurring as a natural phenomenon or through human intervention, changes the ecological balance and context within which disease hosts or vectors and parasites breed, develop, transmit disease. Today, radiation is a common used in medicine to diagnose illnesses, research to treat diseases and industry to generate electricity in nuclear power reactors. Radiation is energy that moves through space or matter at a very high speed. This energy can be in the form of particles, such as alpha or beta particles, which are emitted from radioisotopes. Radioactive Material is material that contains an unstable atomic nucleus releases radiation in the process of changing to a stable form. There are two types of health effects from radiation - threshold and non threshold

  4. Role of natural radiations in human leukemogenesis

    International Nuclear Information System (INIS)

    Jacobson, A.P.; Plato, P.A.; Frigerio, N.A.

    1976-01-01

    Some 3 billion years ago, life arose from a warm pool of primordial ooze amid a constant drizzle of radiation. Steadily, man evolved from the lesser forms of life because of or in spite of his natural background-radiation environment. This study is an attempt to determine to what extent these background radiations are responsible for human disease, namely leukemia. Dose rate data were compared with data on all forms of leukemia in the 50 United States for four population subgroups. For the total U. S., no relation between background radiation and leukemia is apparent. A positive correlation appears, however, if various states are deleted from the analysis. It appears that conditions relative to populations and their environment could mask a radiation effect if in fact one is present

  5. Space Radiation and Risks to Human Health

    Science.gov (United States)

    Huff, Janice L.; Patel, Zarana S.; Simonsen, Lisa C.

    2014-01-01

    The radiation environment in space poses significant challenges to human health and is a major concern for long duration manned space missions. Outside the Earth's protective magnetosphere, astronauts are exposed to higher levels of galactic cosmic rays, whose physical characteristics are distinct from terrestrial sources of radiation such as x-rays and gamma-rays. Galactic cosmic rays consist of high energy and high mass nuclei as well as high energy protons; they impart unique biological damage as they traverse through tissue with impacts on human health that are largely unknown. The major health issues of concern are the risks of radiation carcinogenesis, acute and late decrements to the central nervous system, degenerative tissue effects such as cardiovascular disease, as well as possible acute radiation syndromes due to an unshielded exposure to a large solar particle event. The NASA Human Research Program's Space Radiation Program Element is focused on characterization and mitigation of these space radiation health risks along with understanding these risks in context of the other biological stressors found in the space environment. In this overview, we will provide a description of these health risks and the Element's research strategies to understand and mitigate these risks.

  6. Synchrotron-radiation experiments with recoil ions

    International Nuclear Information System (INIS)

    Levin, J.C.

    1989-01-01

    Studies of atoms, ions and molecules with synchrotron radiation have generally focused on measurements of properties of the electrons ejected during, or after, the photoionization process. Much can also be learned, however, about the atomic or molecular relaxation process by studies of the residual ions or molecular fragments following inner-shell photoionization. Measurements are reported of mean kinetic energies of highly charged argon, krypton, and xenon recoil ions produced by vacancy cascades following inner-shell photoionization using white and monochromatic synchrotron x radiation. Energies are much lower than for the same charge-state ions produced by charged-particle impact. The results may be applicable to design of future angle-resolved ion-atom collision experiments. Photoion charge distributions are presented and compared with other measurements and calculations. Related experiments with synchrotron-radiation produced recoil ion, including photoionization of stored ions and measurement of shakeoff in near-threshold excitation, are briefly discussed. 24 refs., 6 figs., 1 tab

  7. Secondary biogeneous radiation of human organism

    International Nuclear Information System (INIS)

    Kuzin, A.M.; Surkenova, G.N.

    1999-01-01

    When studying samples of three types of tissues of alive healthy human organism (hands, surface of breast, hair) it is shown that hair permanently emit secondary biogeneous radiation (SBR) which may registered with biological detectors. The hypothesis is suggested that natural background radiation permanently exciting biopolymers (proteins, nuclei acids) being present in alive organism in condensed state induces permanently present electromagnetic field of SBR which is vitally important for human organism. The field partly extends beyond the organism, where it is registered with sensitive biological detectors [ru

  8. Review of Nuclear Physics Experiments for Space Radiation

    Science.gov (United States)

    Norbury, John W.; Miller, Jack; Adamczyk, Anne M.; Heilbronn, Lawrence H.; Townsend, Lawrence W.; Blattnig, Steve R.; Norman, Ryan B.; Guetersloh, Stephen B.; Zeitlin, Cary J.

    2011-01-01

    Human space flight requires protecting astronauts from the harmful effects of space radiation. The availability of measured nuclear cross section data needed for these studies is reviewed in the present paper. The energy range of interest for radiation protection is approximately 100 MeV/n to 10 GeV/n. The majority of data are for projectile fragmentation partial and total cross sections, including both charge changing and isotopic cross sections. The cross section data are organized into categories which include charge changing, elemental, isotopic for total, single and double differential with respect to momentum, energy and angle. Gaps in the data relevant to space radiation protection are discussed and recommendations for future experiments are made.

  9. Coherent synchrotron radiation experiments for the LCLS

    International Nuclear Information System (INIS)

    Carlsten, B.E.; Russell, S.J.

    1998-01-01

    The authors describe a coherent synchrotron radiation experiment planned at Los Alamos to support the design of the Linac Coherent Light Source (LCLS) x-ray FEL. Preliminary simulations of the LCLS compressors show that a clever tuning strategy can be used to minimize the electron's beam emittance growth due to noninertial space-charge forces by employing a delicate cancellation of these forces. The purpose of the Los Alamos experiment, using a sub-picosecond chicane compressor, is to benchmark these simulations tools. In this paper, the authors present detailed numerical simulations of the experiment, and point out unique signatures of this effect that are measurable. As predicted previously, the largest emittance growths and induced energy spreads result from the nonradiative components of this space-charge force

  10. Radiation effects on cultured human lymphoid cells

    International Nuclear Information System (INIS)

    Johansson, L.; Nilsson, K.; Carlsson, J.; Larsson, B.; Jakobsson, P.

    1981-01-01

    The cloning efficiency of human normal and malignant lymphoid cells is usually low. Radiation effects in vitro on such cells can therefore not be analysed with conventional cloning. However, this problem can be circumscribed by using the growth extrapolation method. A panel of human leukemia-lymphoma cell-lines representing Epstein-Barr virus carrying lymphoblastoid cells of presumed non-neoplastic derivation and neoplastic T- and B-lymphocytes was used to test the efficiency of this method. The sensitivity to radiation could be determined for all these cell types. The growth extrapolation method gave generally the same result as conventional cloning demonstrated by comparison with one exceptional cell-line with capacity for cloning in agar. The sensitivity varied largely between the different cell types. A common feature was that none of the cell lines had a good capacity to accumulate sublethal radiation injury. (Auth.)

  11. Atmospheric Ionizing Radiation and Human Exposure

    Science.gov (United States)

    Wilson, John W.; Mertens, Christopher J.; Goldhagen, Paul; Friedberg, W.; DeAngelis, G.; Clem, J. M.; Copeland, K.; Bidasaria, H. B.

    2005-01-01

    Atmospheric ionizing radiation is of interest, apart from its main concern of aircraft exposures, because it is a principal source of human exposure to radiations with high linear energy transfer (LET). The ionizing radiations of the lower atmosphere near the Earth s surface tend to be dominated by the terrestrial radioisotopes. especially along the coastal plain and interior low lands, and have only minor contributions from neutrons (11 percent). The world average is substantially larger but the high altitude cities especially have substantial contributions from neutrons (25 to 45 percent). Understanding the world distribution of neutron exposures requires an improved understanding of the latitudinal, longitudinal, altitude and spectral distribution that depends on local terrain and time. These issues are being investigated in a combined experimental and theoretical program. This paper will give an overview of human exposures and describe the development of improved environmental models.

  12. Atmospheric Ionizing Radiation and Human Exposure

    Science.gov (United States)

    Wilson, J. W.; Goldhagen, P.; Friedberg, W.; DeAngelis, G.; Clem, J. M.; Copeland, K.; Bidasaria, H. B.

    2004-01-01

    Atmospheric ionizing radiation is of interest, apart from its main concern of aircraft exposures, because it is a principal source of human exposure to radiations with high linear energy transfer (LET). The ionizing radiations of the lower atmosphere near the Earth s surface tend to be dominated by the terrestrial radioisotopes especially along the coastal plain and interior low lands and have only minor contributions from neutrons (11 percent). The world average is substantially larger but the high altitude cities especially have substantial contributions from neutrons (25 to 45 percent). Understanding the world distribution of neutron exposures requires an improved understanding of the latitudinal, longitudinal, altitude and spectral distribution that depends on local terrain and time. These issues are being investigated in a combined experimental and theoretical program. This paper will give an overview of human exposures and describe the development of improved environmental models.

  13. Human exposure to low level ionising radiation

    International Nuclear Information System (INIS)

    Paix, David

    1988-01-01

    This paper describes the low-level radiation sources and their effects on human populations, from a global perspective. 'Low-level' means exposures in the range of the natural background to which everybody is exposed. The quoted values are whole-world averages, but individual variations are mentioned in a few cases. (author). 22 refs

  14. Introduction to radiation and human health

    International Nuclear Information System (INIS)

    Anon.

    1981-01-01

    This introductory chapter presents an overview of topics that are examined throughout the book. There are brief discussions on basic scientific notation, epidemiology, risk assessment, and the use of assumptions and approximations in scientific research. The book presents evidence that ionizing radiation causes a variety of human health hazards. The health hazards evaluated in detail are cancer and chromosomal damage

  15. Radiation hybrid mapping of human chromosome 18

    International Nuclear Information System (INIS)

    Francke, U.; Moon, A.J.; Chang, E.; Foellmer, B.; Strauss, B.; Haschke, A.; Chihlin Hsieh; Geigl, E.M.; Welch, S.

    1990-01-01

    The authors have generated a Chinese hamster V79/380-6 HPRT minus x human leukocyte hybrid cell line (18/V79) with chromosome 18 as the only human chromosome that is retained at high frequency without specific selection. Hybrid cells were selected in HAT medium, and 164 individual colonies were isolated. Of 110 colonies screened for human DNA by PCR amplification using a primer specific for human Alu repeats 67 (61%) were positive. These were expanded in culture for large-scale DNA preparations. Retesting expanded clones by PCR with Alu and LINE primers has revealed unique patterns of amplification products. In situ hybridization of biotin labelled total human DNA to metaphase spreads from various hybrids revealed the presence of one or more human DNA fragments integrated in hamster chromosomes. The authors have generated a resource that should allow the construction of a radiation map, to be compared with the YAC contig map also under construction in their laboratory

  16. Radiation-induced gene amplification in rodent and human cells

    International Nuclear Information System (INIS)

    Luecke-Huhle, C.; Gloss, B.; Herrlich, P.

    1990-01-01

    Ionizing and UV radiations induce amplification of SV40 DNA sequences integrated in the genome of Chinese hamster cells and increase amplification of the dihydrofolate reductase (DHFR) gene during methotrexate selection in human skin fibroblasts of a patient with ataxia telangiectasia. Various types of external (60-Co-γ-rays, 241-Am-α-particles, UV) or internal radiation (caused by the decay of 125 I incorporated into DNA in form of I-UdR) were applied. By cell fusion experiments it could be shown that SV40 gene amplification is mediated by one or several diffusible trans-acting factors induced or activated in a dose dependent manner by all types of radiation. One of these factors binds to a 10 bp sequence within the minimal origin of replication of SV40. In vivo competition with an excess of a synthetic oligonucleotide comprising this sequence blocks radiation-induced amplification. (author) 25 refs.; 8 figs

  17. [Effects of radiation exposure on human body].

    Science.gov (United States)

    Kamiya, Kenji; Sasatani, Megumi

    2012-03-01

    There are two types of radiation health effect; acute disorder and late on-set disorder. Acute disorder is a deterministic effect that the symptoms appear by exposure above a threshold. Tissues and cells that compose the human body have different radiation sensitivity respectively, and the symptoms appear in order, from highly radiosensitive tissues. The clinical symptoms of acute disorder begin with a decrease in lymphocytes, and then the symptoms appear such as alopecia, skin erythema, hematopoietic damage, gastrointestinal damage, central nervous system damage with increasing radiation dose. Regarding the late on-set disorder, a predominant health effect is the cancer among the symptoms of such as cancer, non-cancer disease and genetic effect. Cancer and genetic effect are recognized as stochastic effects without the threshold. When radiation dose is equal to or more than 100 mSv, it is observed that the cancer risk by radiation exposure increases linearly with an increase in dose. On the other hand, the risk of developing cancer through low-dose radiation exposure, less 100 mSv, has not yet been clarified scientifically. Although uncertainty still remains regarding low level risk estimation, ICRP propound LNT model and conduct radiation protection in accordance with LNT model in the low-dose and low-dose rate radiation from a position of radiation protection. Meanwhile, the mechanism of radiation damage has been gradually clarified. The initial event of radiation-induced diseases is thought to be the damage to genome such as radiation-induced DNA double-strand breaks. Recently, it is clarified that our cells could recognize genome damage and induce the diverse cell response to maintain genome integrity. This phenomenon is called DNA damage response which induces the cell cycle arrest, DNA repair, apoptosis, cell senescence and so on. These responses act in the direction to maintain genome integrity against genome damage, however, the death of large number of

  18. Ionizing radiation effect on human reproduction

    International Nuclear Information System (INIS)

    Jirous, J.

    1987-01-01

    A review is presented of the existing knowledge on the adverse effects of ionizing radiation on human reproduction. Some interesting findings have been obtained by interapolating the results of studies in mouse embryos to humans, important knowledge has been obtained in studies involving the population of Hiroshima and Nagasaki. The review summarizes the knowledge in the following conclusions: (1) prior to the blastocyst stage, the mammalian embryo is insensitive to teratogenic and growth retarding radiation effects but is highly sensitive to the lethal radiation effect; (2) in the early organogenesis, the embryo is very sensitive to growth retarding, teratogenic and lethal radiation effects. It can, however, partly offset growth retardation in the post-natal period; (3) in the early fetal development stage, the fetus shows reduced sensitivity to teratogenic damage of many organs; sensitivity of the central nervous system and growth retardation remain which can only be compensated post-natally with difficulties; (4) in the late stage of pregnancy the fetus is not significantly deformed as a result of irradiation but permanent cellular depletion can result in various organs and tissues post-natally if radiation doses are high. (L.O.). 22 refs

  19. Needs For Education And Training In Radiation Protection: Kenya Experience

    International Nuclear Information System (INIS)

    Mustapha, A.O.; Kalambuka, H.A.; Maina, D.M.; Onyatta, J.; Kioko, J.; Masinza, S.; Kamande, J.

    2008-01-01

    Many nations, Kenya inclusive, have insufficient number of trained personnel to deal with regulatory and technical radiation safety issues. The IAEA Basic safety standards and the 96/29 EURATOM Directive put emphasis on education and training. Both organizations as well as IRPA have been proactive on training and educational issues. The Eastern Africa Association for Radiation Protection (EAARP) in collaboration with some national institutions has also been involved in awareness creation and provision of training and education opportunities for users of radioactive sources as well as the general public on issues related to radiation protection. Experience so far indicates that public demand is high for information and education in this area. In this paper we have identified the educational needs in radiation protection in the region using the Kenyan experience. The paper has also enumerated the available educational and training infrastructures, the human resources, as well as the important stake holders and their roles if a sustainable education and training program were to be developed in the region

  20. Operational experience of gamma radiation processing facility

    International Nuclear Information System (INIS)

    Patel, Nilesh

    2014-01-01

    Universal lSO-MED is now proud to announce an extension of its irradiation service for low-dose applications specifically in agriculture commodities, food and healthcare applications with the start of Gujarat Agro Radiation Processing Facility at Village: Bavla, Ahmedabad (A Government Enterprise) Operated, Maintained and Managed by Universal Medicap Ltd. Availability of hygienic, safe and nutritious food commodities is essential for any sustainable human development. Food stability is an important element of economic stability and self-reliance of a nation. Though the need to preserve food has been felt by the mankind since the time immemorial, it is even stronger in today's context. The rising population and increasing gap between demand and supply, agro-climatic conditions, in adequate post-harvest practices, seasonal nature of produce and long distances between production and consumption centers underscore the need to device improved conservation and preservation strategies

  1. Human radiation studies: Remembering the early years. Oral history of Merril Eisenbud, January 26, 1995

    International Nuclear Information System (INIS)

    1995-05-01

    Merril Eisenbud was interviewed on January 26, 1995 by representatives of the US DOE Office of Human Radiation Experiments. Following a brief biographical sketch, Mr. Eisenbud relates his remembrances as the AEC's first industrial hygienist, the setting up of AEC's Health and Safety Laboratory, monitoring radioactive fallout, and use or exposure of humans to radiation

  2. Health physics measurements of laser radiation: Experience and competence wanted

    International Nuclear Information System (INIS)

    Fischer, P.G.

    1998-01-01

    Measurement of the parameters required for an analysis of hazards involved is a complex task in terms of measuring techniques and calibration, and a costly procedure at that. Although part of the evaluation work can be done with the support of computers, evaluation and interpretation of measured information requires the experience and competence of the human expert. It is to be hoped that the computer industry will soon have developed turn-key solutions of universal applicability for analytical tasks of this kind, so that in the near future determination of the source terms, especially for LED or IRED radiation, will be an easy task. (orig./CB) [de

  3. Radiation effects on the developing human brain

    International Nuclear Information System (INIS)

    1993-01-01

    The developing human brain has been shown to be especially sensitive to ionizing radiation. Mental retardation has been observed in the survivors of the atomic bombings in Japan exposed in utero during sensitive periods, and clinical studies of pelvically irradiated pregnant women have demonstrated damaging effects on the fetus. In this annex the emphasis is on reviewing the results of the study of the survivors of the atomic bombings in Japan, although the results of other human epidemiological investigations and of pertinent experimental studies are also considered. Refs, 3 figs, 10 tabs

  4. Static speckle experiments using white synchrotron radiation

    Energy Technology Data Exchange (ETDEWEB)

    Sant, Tushar; Panzner, Tobias; Pietsch, Ullrich [Solid State Physics Group, University of Siegen (Germany)

    2008-07-01

    Static speckle experiments were performed using coherent white X-ray radiation from a bending magnet at BESSYII. Semiconductor and polymer surfaces were investigated under incidence condition smaller than the critical angle of total external reflection. The scattering pattern of the sample results from the illumination function modified by the surface undulations. The periodic oscillations are caused by the illumination function whereas other irregular features are associated with sample surface. The speckle map of reflection from a laterally periodic structure like GaAs grating is studied. Under coherent illumination the grating peaks split into speckles because of fluctuations on the sample surface. It is important to understand which length scales on the sample surface are responsible for the oscillations in reflectivity map. To investigate this experiments are done with a triangular shaped sample. Different parts of the sample are illuminated with the footprint on the sample larger or smaller than the actual sample length. This gives prior information about total illuminated area on the sample. Using this additional information a detailed surface profile of the sample is reconstructed.

  5. Fluid Line Evacuation and Freezing Experiments for Digital Radiator Concept

    Science.gov (United States)

    Berisford, Daniel F.; Birur, Gajanana C.; Miller, Jennifer R.; Sunada, Eric T.; Ganapathi, Gani B.; Stephan, Ryan; Johnson, Mark

    2011-01-01

    The digital radiator technology is one of three variable heat rejection technologies being investigated for future human-rated NASA missions. The digital radiator concept is based on a mechanically pumped fluid loop with parallel tubes carrying coolant to reject heat from the radiator surface. A series of valves actuate to start and stop fluid flow to di erent combinations of tubes, in order to vary the heat rejection capability of the radiator by a factor of 10 or more. When the flow in a particular leg is stopped, the fluid temperature drops and the fluid can freeze, causing damage or preventing flow from restarting. For this reason, the liquid in a stopped leg must be partially or fully evacuated upon shutdown. One of the challenges facing fluid evacuation from closed tubes arises from the vapor generated during pumping to low pressure, which can cause pump cavitation and incomplete evacuation. Here we present a series of laboratory experiments demonstrating fluid evacuation techniques to overcome these challenges by applying heat and pumping to partial vacuum. Also presented are results from qualitative testing of the freezing characteristics of several different candidate fluids, which demonstrate significant di erences in freezing properties, and give insight to the evacuation process.

  6. Advertising's new medium: human experience.

    Science.gov (United States)

    Rayport, Jeffrey F

    2013-03-01

    We live in a media-saturated world, where consumers are drowning in irrelevant messages delivered from the web, TV, radio, print, outdoor displays, and a proliferating array of mobile devices. Advertising strategies built on persuading through interruption, repetition, and brute ubiquity are increasingly ineffective. To win consumers' attention and trust, marketers must think less about what advertising says to its targets and more about what it does for them. Rayport outlines four domains of human experience: In the public sphere people move from one place or activity to another, both online and off. In the social sphere they interact with and relate to one another. In the tribal sphere they affiliate with groups to define or express their identity. In the psychological sphere they connect language with specific thoughts and feelings. Savvy marketers think about crafting messages that consumers will welcome in these domains. Zappos did that when it placed ads in airport security bins (the public sphere)--reaching people whose minds may be on their shoes. Nintendo identified young mothers who were willing to host Wii parties and provided them with everything they needed for these social-sphere events. Yelp's Elite Squad of reviewers have a heightened sense of tribal affiliation that makes them powerful brand ambassadors. Life is good Inc. is rooted in the psychological sphere: It advertises only through the optimism-promoting logo and slogan on its products.

  7. Exposure to UV radiation and human health

    Science.gov (United States)

    Kimlin, Michael G.

    2005-08-01

    This paper will overview the significant issues facing researchers in relating the impact of exposure to sunlight and human health. Exposure to solar ultraviolet radiation is the major causative factor in most sun-related skin and eye disorders, however, very little is known quantitatively about human UV exposures. Interestingly, human exposure to sunlight also has a nutritional impact, namely the development of pre-Vitamin D, which is an important nutrient in bone health. New research suggest that low vitamin D status may be a causative factor in the development of selective types of cancer and autoimminue diseases, as well as a contributing factor in bone health. The 'health duality' aspect of sunlight exposure is an interesting and controversial topic that is a research focus of Kimlin's research group.

  8. Radiation pollution: present and future perplexities about human rights

    International Nuclear Information System (INIS)

    Kumar, Raj; Bharti, Mukesh

    2012-01-01

    Out of the several pollutions included in environmental pollution, the radiation pollution is also a part of this, which is most damageable and serious for the society. Historical evidences reveal about the devastating effects of radiation pollution on human being. No form of pollution exists in the world which influences the human race with its devastating affects for more than one generation except radiation pollution. The radiation pollution affects human health in several ways. It is a man made problem and also affects human rights of masses for which state are responsible ultimately. The radiation pollution affects a big spectrum of human rights. The sources of radiation pollution and its impact on human health may be different according to the sources. These sources may be classified as electronic goods, Nuclear tests, Nuclear war, Reactors and thermal plants etc. Although we have some legal provisions to handle the problem of radiation pollution but there is no specific laws available for the protection and promotion of human rights from radiation pollution in the lights of international human rights principles. At present, there is no human right oriented policy framework is available to protect and promote the human rights of the radiation pollutions sufferers. The paper explores Present and Future Perplexities about Human Rights. It also tells about the available legal framework, state obligations and judicial responses for radiation pollution. The paper concludes with some suggestions in the light of present and future perplexities about human rights. (author)

  9. Radiation sensitivity of human malignant lymphocytes

    International Nuclear Information System (INIS)

    Seshadri, R.; Matthews, C.; Morley, A.A.

    1985-01-01

    A simple and rapid in vitro technique to assess the sensitivity of human malignant lymphocytes to roentgen irradiation is described. A variety of established malignant lymphocyte cell lines were cloned in microwells and clone survival was used as the end-point. The survival of the clonogenic malignant lymphocyte down to a fraction of approximately 0.001 could be measured accurately. Except for a T-cell line, the radiation sensitivities of the cell lines were similar to that of normal T-lymphocytes. (orig.)

  10. A radiopharmacological study without human radiation exposure

    International Nuclear Information System (INIS)

    Loew, D.; Graul, E.H.; Kunkel, R.

    1984-01-01

    The development, study and control of new drugs today is hardly conceivable without nuclear medicine studies. Nuclear physicians on ethical commissions bear great responsibility in the planning and execution of such studies. In order to protect subjects and patients those nuclear techniques are therefore to be welcome which do not include exposure to radiation. Nuclear techniques used in in-vitro diagnostics (RIA) and the determination of naturally occurring nuclides incorporated in the human body belong to this category. With the aid of a clinico-pharmacological study of a new combination of diuretics it is shown that both methods supply valuable pharmacodynamic evidence. (orig.) [de

  11. Radiation Protection Officer certification scheme. Malaysian experience

    International Nuclear Information System (INIS)

    Pungut, Noraishah; Razali, Noraini; Mod Ali, Noriah

    2011-01-01

    In Malaysia, the need for maintaining competency in radiation protection is emerging, focusing on the qualification of Radiation Protection Officers (RPO). Regulation 23 of Malaysian Radiation Protection (Basic Safety Standards) Regulations 1988, requires the applicant to employ an RPO, with the necessary knowledge, skill and training, enabling effective protection of individuals and minimizing danger to life, property and the environment for all activities sought to be licensed. An RPO must demonstrate the knowledge required, by attending RPO courses organised by an accredited agency and pass the RPO certification examination. Maintaining a high level of competency is crucial for future development of safe applications of ionising radiation. The major goal of training is to provide essential knowledge and skills and to foster correct attitudes on radiation protection and safe use of radiation sources. Assessment of the competency is through theoretical and practical examination. A standard criterion on the performance of the individuals evaluated has been established and only those who meet this criterion can be accepted as certified RPO. The National Committee for the Certification of Radiation Protection Officer (NCCRPO), comprising experts in various fields, is responsible to review and update requirements on competency of a certified RPO. With increasing number of candidates (i.e. 701 in 2008) and the international requirement for radioactive source security, it is incumbent upon the NCCRPO to improve the syllabus of the certification scheme. The introduction of a Radiation Protection Advisor (RPA) to provide service and advice to the radiation industry in Malaysia is also seriously considered. (author)

  12. Genetic consequences of the influence of ionizing radiation on humans

    International Nuclear Information System (INIS)

    Mosse, I.B.

    2011-01-01

    There is no direct evidence that exposure of parents to ionizing radiation leads to excess heritable disease in offspring. What is the difference between human and other species in which radiation induced mutations are easily registered? During evolution germ cell selection ex vivo has been changed to a selection in vivo and we cannot observe such selection of radiation damaged cells in human.

  13. Radiation in the human environment: health effects, safety and acceptability

    International Nuclear Information System (INIS)

    Gonzalez, A.J.; Anderer, J.

    1990-01-01

    This paper reports selectively on three other aspects of radiation (used throughout to mean ionizing radiation) in the human environment: the human health effects of radiation, radiation safety policy and practices, and the acceptability of scientifically justified practices involving radiation exposures. Our argument is that the science of radiation biology, the judgemental techniques of radiation safety, and the social domain of radiation acceptability express different types of expertise that should complement - and not conflict with or substitute for - one another. Unfortunately, communication problems have arisen among these three communities and even between the various disciplines represented within a community. These problems have contributed greatly to the misperceptions many people have about radiation and which are frustrating a constructive dialogue on how radiation can be harnessed to benefit mankind. Our analysis seeks to assist those looking for a strategic perspective from which to reflect on their interaction with practices involving radiation exposures. (author)

  14. Chapter 8. Ionisation radiation and human organism. Radioactivity of human tissues

    International Nuclear Information System (INIS)

    Toelgyessy, J.; Harangozo, M.

    2000-01-01

    This is a chapter of textbook of radioecology for university students. In this chapter authors deal with ionisation radiation and human organism as well as with radioactivity of human tissues. Chapter consists of next parts: (1) Radiation stress of human organism; (2) Radioactivity of human tissues and the factors influencing radioactive contamination; (3) Possibilities of decreasing of radiation stress

  15. Experience of water chemistry and radiation levels in Swedish BWRs

    International Nuclear Information System (INIS)

    Ivars, R.; Elkert, J.

    1981-01-01

    From the BWR operational experience in Sweden it has been found that the occupational radiation exposures have been comparatively low in an international comparison. One main reason for the favourable conditions is the good water chemistry performance. This paper deals at first with the design considerations of water chemistry and materials selection. Next, the experience of water chemistry and radiation levels are provided. Finally, some methods to further reduce the radiation sources are discussed. (author)

  16. Plasma radiation in tokamak disruption simulation experiments

    International Nuclear Information System (INIS)

    Arkhipov, N.; Bakhtin, V.; Safronov, V.; Toporkov, D.; Vasenin, S.; Zhitlukhin, A.; Wuerz, H.

    1995-01-01

    Plasma impact results in sudden evaporation of divertor plate material and produces a plasma cloud which acts as a protective shield. The incoming energy flux is absorbed in the plasma shield and is converted mainly into radiation. Thus the radiative characteristics of the target plasma determine the dissipation of the incoming energy and the heat load at the target. Radiation of target plasma is studied at the two plasma gun facility 2MK-200 at Troitsk. Space- and time-resolved spectroscopy and time-integrated space-resolved calorimetry are employed as diagnostics. Graphite and tungsten samples are exposed to deuterium plasma streams. It is found that the radiative characteristics depend strongly on the target material. Tungsten plasma arises within 1 micros close to the surface and shows continuum radiation only. Expansion of tungsten plasma is restricted. For a graphite target the plasma shield is a mixture of carbon and deuterium. It expands along the magnetic field lines with a velocity of v = (3--4) 10 6 cm/s. The plasma shield is a two zone plasma with a hot low dense corona and a cold dense layer close to the target. The plasma corona emits intense soft x-ray (SXR) line radiation in the frequency range from 300--380 eV mainly from CV ions. It acts as effective dissipation system and converts volumetrically the incoming energy flux into SXR radiation

  17. Radiation enhanced reactivation of irradiated human adenovirus type 2 in human cells

    International Nuclear Information System (INIS)

    Jeeves, W.P.

    1981-04-01

    Radiation-enhanced reactivation (ER) of a radiation-damaged mammalian virus is the term given to the observation that the survival of irradiated virus can be enhanced by irradiation of an appropriate host cell prior to infection. In this work, both UV-enhanced reactivation (UVER) and gamma-ray-enhanced reactivation (γRER) of irradiated human adenovirus type 2 (AD 2) were studied in a variety of normal and DNA repair-deficient human fibroblast host cell strains. In order to examine the lesion specificity of ER in human cells, experiments were performed using UV-irradiated and γ-irradiated virus. The investigation was carried out using a sensitive technique of indirect immunofluorescence, according to which irradiated and unirradiated cell cultures were infected with irradiated or unirradiated AD 2 and were subsequently examined for the presence of viral structural antigens ('V' Ag) at a fixed time after infection

  18. Research attitudes and experiences of radiation therapists

    International Nuclear Information System (INIS)

    Scutter, Sheila; Halkett, Georgia

    2003-01-01

    An important factor in professional status is the ongoing development of the area as a result of research findings. However, involvement by radiation therapists in research, publication and higher degree study is limited. The aim of the current study was to investigate the attitudes of radiation therapists towards research, and to investigate the major factors contributing to their limited participation in research. To achieve this, an anonymous questionnaire was developed and distributed to radiation therapists working at the Royal Adelaide Hospital (RAH). The study found that radiation therapists at the RAH are interested in research but there are several factors that limit their involvement. These factors include limited knowledge about research processes, lack of support and lack of time to undertake research. Copyright (2003) Australian Institute of Radiography

  19. Differential sensitivity of Chironomus and human hemoglobin to gamma radiation

    International Nuclear Information System (INIS)

    Gaikwad, Pallavi S.; Panicker, Lata; Mohole, Madhura; Sawant, Sangeeta; Mukhopadhyaya, Rita; Nath, Bimalendu B.

    2016-01-01

    Chironomus ramosus is known to tolerate high doses of gamma radiation exposure. Larvae of this insect possess more than 95% of hemoglobin (Hb) in its circulatory hemolymph. This is a comparative study to see effect of gamma radiation on Hb of Chironomus and humans, two evolutionarily diverse organisms one having extracellular and the other intracellular Hb respectively. Stability and integrity of Chironomus and human Hb to gamma radiation was compared using biophysical techniques like Dynamic Light Scattering (DLS), UV-visible spectroscopy, fluorescence spectrometry and CD spectroscopy after exposure of whole larvae, larval hemolymph, human peripheral blood, purified Chironomus and human Hb. Sequence- and structure-based bioinformatics methods were used to analyze the sequence and structural similarities or differences in the heme pockets of respective Hbs. Resistivity of Chironomus Hb to gamma radiation is remarkably higher than human Hb. Human Hb exhibited loss of heme iron at a relatively low dose of gamma radiation exposure as compared to Chironomus Hb. Unlike human Hb, the heme pocket of Chironomus Hb is rich in aromatic amino acids. Higher hydophobicity around heme pocket confers stability of Chironomus Hb compared to human Hb. Previously reported gamma radiation tolerance of Chironomus can be largely attributed to its evolutionarily ancient form of extracellular Hb as evident from the present study. -- Highlights: •Comparison of radiation tolerant Chironomus Hb and radiation sensitive Human Hb. •Amino acid composition of midge and human heme confer differential hydrophobicity. •Heme pocket of evolutionarily ancient midge Hb provide gamma radiation resistivity.

  20. Differential sensitivity of Chironomus and human hemoglobin to gamma radiation

    Energy Technology Data Exchange (ETDEWEB)

    Gaikwad, Pallavi S. [Stress Biology Research Laboratory, Department of Zoology, Savitribai Phule University, Pune, 411007 (India); Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085 (India); Panicker, Lata [Solid State Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085 (India); Mohole, Madhura; Sawant, Sangeeta [Bioinformatics Center, Savitribai Phule Pune University, Pune, 411007 (India); Mukhopadhyaya, Rita [Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085 (India); Nath, Bimalendu B., E-mail: bbnath@gmail.com [Stress Biology Research Laboratory, Department of Zoology, Savitribai Phule University, Pune, 411007 (India)

    2016-08-05

    Chironomus ramosus is known to tolerate high doses of gamma radiation exposure. Larvae of this insect possess more than 95% of hemoglobin (Hb) in its circulatory hemolymph. This is a comparative study to see effect of gamma radiation on Hb of Chironomus and humans, two evolutionarily diverse organisms one having extracellular and the other intracellular Hb respectively. Stability and integrity of Chironomus and human Hb to gamma radiation was compared using biophysical techniques like Dynamic Light Scattering (DLS), UV-visible spectroscopy, fluorescence spectrometry and CD spectroscopy after exposure of whole larvae, larval hemolymph, human peripheral blood, purified Chironomus and human Hb. Sequence- and structure-based bioinformatics methods were used to analyze the sequence and structural similarities or differences in the heme pockets of respective Hbs. Resistivity of Chironomus Hb to gamma radiation is remarkably higher than human Hb. Human Hb exhibited loss of heme iron at a relatively low dose of gamma radiation exposure as compared to Chironomus Hb. Unlike human Hb, the heme pocket of Chironomus Hb is rich in aromatic amino acids. Higher hydophobicity around heme pocket confers stability of Chironomus Hb compared to human Hb. Previously reported gamma radiation tolerance of Chironomus can be largely attributed to its evolutionarily ancient form of extracellular Hb as evident from the present study. -- Highlights: •Comparison of radiation tolerant Chironomus Hb and radiation sensitive Human Hb. •Amino acid composition of midge and human heme confer differential hydrophobicity. •Heme pocket of evolutionarily ancient midge Hb provide gamma radiation resistivity.

  1. 1D radiation analysis for the fusion ignition experiment ZEPHYR

    International Nuclear Information System (INIS)

    Brockmann, H.; Ohlig, U.; Krause, H.

    1979-11-01

    For the proposed tokamak ignition experiment ZEPHYR a nuclear radiation analysis is performed for both the prompt radiation during a discharge and the delayed radiation after discharges. This analysis is restricted to a one-dimensional geometrical approximation of the apparatus. Nuclear heating data are derived for the prompt radiation and the shielding concept is investigated. Results for the delayed radiation are given for three activation scenarios, that are anticipated for machine operation. The cooling phase after one of these scenarios is investigated in some detail in order to trace the dominant contributions to biological dose rates back to machine components and to specific activation reactions. (orig.)

  2. Impact of ultraviolet radiation on humans

    International Nuclear Information System (INIS)

    Cesarini, J.P.

    2001-01-01

    Solar radiation, including its ultraviolet (UV) components is a key factor in life on Earth. While small quantities of UV are beneficial for people (for example, through the production of vitamin D), the considerable amount to which people sometimes expose themselves may have extremely noxious effects including actinic erythema, sunburn, photo-induced diseases, photo-worsened diseases, actinic ageing and skin cancers. Since the last century, human exposure to UV has increased either by social-behaviour modifications, or by anthropogenic disruption to the environment through, among other things, industrial development. The World Health Organisation's (WHO) INTERSUN programme has several components: action for reconstruction of the ozone layer through, for example, preventing dumping of chlorofluorocarbons; creation and popularisation of a global UV index; prevention campaigns underlining the risks from UV exposure including dissemination of information to daily newspapers. These are all aimed at reducing the amount of UV radiation that people receive. In addition the WHO advises against exposure to UV artificial sources to reduce overall the quantity of UV received. (author)

  3. Impact of ultraviolet radiation on humans

    Energy Technology Data Exchange (ETDEWEB)

    Cesarini, J.P. [Laboratoire de Recherche sur les Tumeurs de la Peau Humaine, INSERM, Paris (France)

    2001-07-01

    Solar radiation, including its ultraviolet (UV) components is a key factor in life on Earth. While small quantities of UV are beneficial for people (for example, through the production of vitamin D), the considerable amount to which people sometimes expose themselves may have extremely noxious effects including actinic erythema, sunburn, photo-induced diseases, photo-worsened diseases, actinic ageing and skin cancers. Since the last century, human exposure to UV has increased either by social-behaviour modifications, or by anthropogenic disruption to the environment through, among other things, industrial development. The World Health Organisation's (WHO) INTERSUN programme has several components: action for reconstruction of the ozone layer through, for example, preventing dumping of chlorofluorocarbons; creation and popularisation of a global UV index; prevention campaigns underlining the risks from UV exposure including dissemination of information to daily newspapers. These are all aimed at reducing the amount of UV radiation that people receive. In addition the WHO advises against exposure to UV artificial sources to reduce overall the quantity of UV received. (author)

  4. Gamma radiation effects on liofilized human serum

    International Nuclear Information System (INIS)

    Padron Soler, E.; Romay Penabad, Z.; Chavez Ardanza, A.; Hernandez Gonzalez, C.; Martin Gonzalez, O.; Garcia Gonzalez, I.; Prieto Miranda, E.

    1995-01-01

    Human freeze dried serum was artificially contaminated with Flavobacterium sp. for studying the effects of gamma radiation of it. The radiobiological parameters of the contaminator were determined and the sterilization dose was set. The quality of the product irradiated at both, calculated sterilization dose (8.5 kGy) an another one about 25 kGy was determined. It was made according to: sterility testing, total proteins, pH enzymes (alanina-aminotransferase, aspartato-aminotransferase, alkaline phosphatase), protein electrophoresis, fast performance liquid chromatographic and effect on the cellular growth. From the latter was concluded that the calculated sterilization dose was adequate form keeping the biological properties and viability of the irradiated serum. Nevertheless, the dose of 25 k Gy was not adequate because of its dangerous effects on the cell culture

  5. Applications of radiation processing: SRI experiences

    International Nuclear Information System (INIS)

    Rajput, Sanjay

    2014-01-01

    Shriram Applied Radiation Centre (SARC) is a part of Shriram Institute for Industrial Research (SRI), and was established in 1986, in collaboration with Bhabha Atomic Research Centre (BARC), Board of Radiation and Isotope Technology (BRIT), Department of Atomic Energy (DAE), Atomic Energy Regulatory Board (AERB). SARC was established with a objective to popularize the radiation processing technology for various applications. SARC is a fully automatic, computerized plant setup as per the design and norms of BRIT/AERB for round the clock fail safe operations. The capacity of SARC Irradiator is 800 kCi of Cobalt -60 source which can process up to 10,000 cubic meters of material (0.1g/cc) at 25 kGy level

  6. Counterpropagating Radiative Shock Experiments on the Orion Laser.

    Science.gov (United States)

    Suzuki-Vidal, F; Clayson, T; Stehlé, C; Swadling, G F; Foster, J M; Skidmore, J; Graham, P; Burdiak, G C; Lebedev, S V; Chaulagain, U; Singh, R L; Gumbrell, E T; Patankar, S; Spindloe, C; Larour, J; Kozlova, M; Rodriguez, R; Gil, J M; Espinosa, G; Velarde, P; Danson, C

    2017-08-04

    We present new experiments to study the formation of radiative shocks and the interaction between two counterpropagating radiative shocks. The experiments are performed at the Orion laser facility, which is used to drive shocks in xenon inside large aspect ratio gas cells. The collision between the two shocks and their respective radiative precursors, combined with the formation of inherently three-dimensional shocks, provides a novel platform particularly suited for the benchmarking of numerical codes. The dynamics of the shocks before and after the collision are investigated using point-projection x-ray backlighting while, simultaneously, the electron density in the radiative precursor was measured via optical laser interferometry. Modeling of the experiments using the 2D radiation hydrodynamic codes nym and petra shows very good agreement with the experimental results.

  7. Ethacrynic acid: a novel radiation enhancer in human carcinoma cells

    International Nuclear Information System (INIS)

    Khil, Mark S.; Sang, Hie Kim; Pinto, John T.; Jae, Ho Kim

    1996-01-01

    Purpose: Because agents that interfere with thiol metabolism and glutathione S-transferase (GST) functions have been shown to enhance antitumor effects of alkylating agents in vitro and in vivo, the present study was conceived on the basis that an inhibitor of GST would enhance the radiation response of some selected human carcinoma cells. Ethacrynic acid (EA) was chosen for the study because it is an effective inhibitor of GST and is a well known diuretic in humans. Methods and Materials: Experiments were carried out with well-established human tumor cells in culture growing in Eagle's minimum essential medium (MEM) supplemented with 10% fetal calf serum (FCS). Cell lines used were MCF-7, MCF-7 adriamycin resistant (AR) cells (breast carcinoma), HT-29 cells (colon carcinoma), DU-145 cells (prostate carcinoma), and U-373 cells (malignant glioma). Cell survival following the exposure of cells to drug alone, radiation alone, and a combined treatment was assayed by determining the colony-forming ability of single plated cells in culture to obtain dose-survival curves. The drug enhancement ratio was correlated with levels of GST. Results: The cytotoxicity of EA was most pronounced in MCF-7, U-373, and DU-145 cells compared to MCF-7 AR and HT-29 cells. The levels of GST activity were found to be lower in those EA-sensitive cells. A significant radiation enhancement was obtained with EA-sensitive cells exposed to nontoxic concentrations of the drug immediately before or after irradiation. The sensitizer enhancement ratio (SER) of MCF-7 cells was 1.55 with EA (20 μg/ml), while the SER of MCF-7 AR was less than 1.1. Based on five different human tumor cells, a clear inverse relationship was demonstrated between the magnitude of SER and GST levels of tumor cells prior to the combined treatment. Conclusion: The present results suggest that EA, which acts as both a reversible and irreversible inhibitor of GST activity, could significantly enhance the radiation response of

  8. Chronic radiation enteritis: A community hospital experience

    International Nuclear Information System (INIS)

    Fenner, M.N.; Sheehan, P.; Nanavati, P.J.; Ross, D.S.

    1989-01-01

    A retrospective study was undertaken to evaluate the operative management of patients with chronic radiation enteropathy. Thirty-eight affected patients from 1974 to 1986 were reviewed. Patients with recurrent cancer responsible for symptoms were excluded. Seventy-one percent of patients presented with bowel obstruction. Twenty-one patients were treated with bowel resection, while 17 were treated with a bypass procedure or diverting ostomy alone. Overall morbidity was 45%, and postoperative mortality was 16%. Patients in the bypass group were significantly older than those in the resection group (70.3 vs. 55.5 years, P = .024), suggesting that age may have been a determinant of the procedure performed. In our study there was no difference in outcome based on preexisting vascular disease, tumor site, type of procedure performed, or radiation dose. We conclude that resection is the procedure of choice in cases of chronic radiation enteritis requiring surgery except in cases with dense adhesions when enteroenterostomal bypass is a viable alternative

  9. Evaluation of the Radiation Environment of the LHCb Experiment

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00341385; Corti, Gloria

    The unprecedented radiation levels of the Large Hadron Collider (LHC) during high-energy proton-proton collisions will have an impact on the operation of its experiments’ detectors and electronics. LHCb, one of the 4 major LHC experiments, has started operation in 2009 and from 2011 onward it has been collecting data at and above its design luminosity. Detectors and associated detector electronics are prone to damage if the radiation levels exceed the expected values. It is essential to monitor the radiation environment of the experimental area and compare it with predictions obtained from simulation studies in order to assess the situation and take corrective action in case of need. Understanding the existing radiation environment will also provide important input to the planning of maintenance and for operation at upgrade luminosity. A set of radiation detectors has been installed in the LHCb experimental area to measure different aspects of its radiation environment. Passive dosimeters including Thermo-L...

  10. Epidemiological studies on radiation carcinogenesis in human populations following acute exposure: nuclear explosions and medical radiation

    International Nuclear Information System (INIS)

    Fabrikant, J.I.

    1981-05-01

    The current knowledge of the carcinogenic effect of radiation in man is considered. The discussion is restricted to dose-incidence data in humans, particularly to certain of those epidemiological studies of human populations that are used most frequently for risk estimation for low-dose radiation carcinogenesis in man. Emphasis is placed solely on those surveys concerned with nuclear explosions and medical exposures

  11. Activation of human immunodeficiency virus by radiation

    International Nuclear Information System (INIS)

    Beer, J.Z.; Zmudzka, B.Z.

    1991-01-01

    It was recently demonstrated that ultraviolet radiation (UVR) can induce the HIV promoter as well as activate the complete virus in cultured cells (Valerie et al., 1988). This and subsequent observations, reviewed in this article, suggest a possibility that radiation exposure may accelerate development of AIDS in HIV-infected individuals. They also indicate that studies on HIV activation by stressors, including radiation, may advance our understanding of some phenomena that follow HIV infection. (author)

  12. Radiation protection for human interplanetary spaceflight and planetary surface operations

    Energy Technology Data Exchange (ETDEWEB)

    Clark, B.C. [Armed Forces Radiobiology Research Inst., Bethesda, MD (United States)]|[DLR Inst. of Aerospace Medicine, Cologne (Germany)]|[NASA, Goddard Space Flight Center, Greenbelt, MD (United States)

    1993-12-31

    Radiation protection issues are reviewed for five categories of radiation exposure during human missions to the moon and Mars: trapped radiation belts, galactic cosmic rays, solar flare particle events, planetary surface emissions, and on-board radiation sources. Relative hazards are dependent upon spacecraft and vehicle configurations, flight trajectories, human susceptibility, shielding effectiveness, monitoring and warning systems, and other factors. Crew cabins, interplanetary mission modules, surface habitats, planetary rovers, and extravehicular mobility units (spacesuits) provide various degrees of protection. Countermeasures that may be taken are reviewed relative to added complexity and risks that they could entail, with suggestions for future research and analysis.

  13. Radiation protection training: twenty year experience in Hungary

    International Nuclear Information System (INIS)

    Pellet, Sandor; Kanyar, Bela; Zagyvay, Peter; Solymosi, Jozsef; Bujtas, Tibor; Feher, Istvan; Giczi, Ferenc; Deme, Sandor; Uray, Istvan

    2008-01-01

    In Hungary, radiation protection training for radiation workers has been introduced in very early, just following the publication of the ICRP recommendation No. 26. Before that, in some of the institutions, radiation protection training was recommended for technicians and medical doctors working in nuclear medicine, X-ray diagnostic radiology and radiation therapy, as well as in some of industrial applications, but not on regular way. Since 1988, radiation protection training regulated by the Ministry of Health and required for all of the workers in radiation workplaces licensed by the authority the State Public Health and Medical Officers Service (SPHAMOS). Decree No. 16/2000. (VI. 8.) EuM of the Minister of Health on the enforcement of Clauses of the Nuclear Law 116/1996 regulates the radiation protection training of Radiation Workers (RW). Annex 4 of Decree sees radiation protection training and in-service training: Persons performing conducted work in the field of the use of the nuclear energy and any other work within legal relationship shall be educated in training and in-service training at an interval of 5 years. Three levels of the training introduced; basic, extended and comprehensive, based on radiation risk related to the given job. Several institutions are involved in performing radiation protection training, such universities, scientific institutions, Regional Radiological Health Centers (RRHC) of SPHAMOS, private enterprises etc. All training course material is subject to accreditation. Most of the faculties of the universities involved in training of natural sciences and engineering provide subjects on the fundamentals of dosimetry, radiobiology and radiation protection within the courses of physics, biophysics, chemistry, biology, ecology etc. These courses take 5-10 contact hours per week on average. The members of the Hungarian Committee of EUTERP Platform summarize their broad experience collected in the past 20 year. (author)

  14. Effect of low doses of ionizing radiation on human health

    International Nuclear Information System (INIS)

    Kovalenko, A.N.

    1990-01-01

    Data are reported on the possible mechanism of biological effects of low doses of ionizing radiation on the human body. The lesioning effect of this radiation resulted in some of the persons in the development of disorders of the function of information and vegetative-regulatory systems determined as a desintegration syndrome. This syndrome is manifested in unspecific neuro-vegetative disorders of the function of most important physiological and homeostatic system of the body leading to weakening of the processes of compensation and adaptation. This condition is characterized by an unspecific radiation syndrome as distinct from acute or chronic radiation disease which is a specific radiation syndrome

  15. Fusion-relevant basic radiation effects: theory and experiment

    International Nuclear Information System (INIS)

    Mansur, L.K.; Coghlan, W.A.; Farrell, K.; Horton, L.L.; Lee, E.H.; Lewis, M.B.; Packan, N.H.

    1983-01-01

    A summary is given of results of the basic radiation effects program at Oak Ridge National Laboratory, which are relevant to fusion reactor materials applications. The basic radiation effects program at ORNL is a large effort with the dual objectives of understanding the atomic and microstructural defect mechanisms underlying radiation effects and of determining principles for the design of radiation resistant materials. A strength of this effort is the parallel and integrated experimental and theoretical approaches in each major research area. The experimental effort is active in electron microscopy, ion irradiations and ion-beam techniques, neutron irradiations, surface analysis and in other areas. The theoretical effort is active in developing the theory of radiation effects for a broad range of phenomena and in applying it to the design and interpretation of experiments and to alloy design

  16. A large area transition radiation detector for the NOMAD experiment

    Science.gov (United States)

    Bassompierre, G.; Bermond, M.; Berthet, M.; Bertozzi, T.; Détraz, C.; Dubois, J.-M.; Dumps, L.; Engster, C.; Fazio, T.; Gaillard, G.; Gaillard, J.-M.; Gouanère, M.; Manola-Poggioli, E.; Mossuz, L.; Mendiburu, J.-P.; Nédélec, P.; Palazzini, E.; Pessard, H.; Petit, P.; Petitpas, P.; Placci, A.; Sillou, D.; Sottile, R.; Valuev, V.; Verkindt, D.; Vey, H.; Wachnik, M.

    1998-02-01

    A transition radiation detector to identify electrons at 90% efficiency with a rejection factor against pions of 10 3 on an area of 2.85 × 2.85 m 2 has been constructed for the NOMAD experiment. Each of its 9 modules includes a 315 plastic foil radiator and a detector plane of 176 vertical straw tubes filled with a xenon-methane gas mixture. Details of the design, construction and operation of the detector are given.

  17. A large area transition radiation detector for the NOMAD experiment

    CERN Document Server

    Bassompierre, Gabriel; Berthet, M; Bertozzi, T; Détraz, C; Dubois, J M; Dumps, Ludwig; Engster, Claude; Fazio, T; Gaillard, G; Gaillard, Jean-Marc; Gouanère, M; Manola-Poggioli, E; Mossuz, L; Mendiburu, J P; Nédélec, P; Palazzini, E; Pessard, H; Petit, P; Petitpas, P; Placci, Alfredo; Sillou, D; Sottile, R; Valuev, V Yu; Verkindt, D; Vey, H; Wachnik, M

    1997-01-01

    A transition radiation detector to identify electrons at 90% efficiency with a rejection factor against pions of 10 3 on an area of 2.85 × 2.85 m 2 has been constructed for the NOMAD experiment. Each of its 9 modules includes a 315 plastic foil radiator and a detector plane of 176 vertical straw tubes filled with a xenon-methane gas mixture. Details of the design, construction and operation of the detector are given.

  18. A unique experiment. Measurement of radiation doses at Vinca

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1960-07-15

    For the first time in the history of the peaceful applications of atomic energy, an experiment was conducted to determine the exact levels of radiation exposure resulting from a reactor incident. The experiment was made at Vinca, Yugoslavia, wherein October 1958 six persons had been subjected to high doses of neutron and gamma radiation during a brief uncontrolled run of a zero-power reactor. One of them died but the other five were successfully treated at the Curie Hospital in Paris. In the case of four of them, the treatment involved the grafting of healthy bone marrow to counteract the effects of radiation on blood-forming tissues. It was recognized that if the effects produced on the irradiated persons could be related to the exact doses of radiation they had received, it would be possible to gain immensely valuable knowledge about the biological consequences of acute and high level radiation exposure on a quantitative basis. It was suggested to the Yugoslav authorities that a dosimetry experiment be conducted at Vinca. The most accurate modern techniques of dosimetry developed at the Oak Ridge National Laboratory were employed during the experiment. Simultaneous measurements of the neutron and gamma doses were made at points where the people had been located. At these points the effects of the radiation on the salt solution in the phantoms were studied. In particular, the energy distribution of the radiation was investigated.It was the ratio between the various components of the radiation that was of special interest in these measurements because this ratio itself would help in determining the exact doses. The dose of one of the components, viz. slow neutrons, had already been determined during the treatment of the patients. If the ratio of the components could be ascertained, the doses of the fast neutrons and gamma rays could also be established because the ratio would not be affected by the power level at which the reactor was operated

  19. Is the precision of human radiation tolerance estimates sufficient for radiation emergency management

    International Nuclear Information System (INIS)

    Lushbaugh, C.C.; Huebner, K.F.; Fry, S.A.; Ricks, R.C.

    1982-01-01

    Retrospective clinical evaluations of the deleterious consequences of accidental and therapeutic radiation exposures have provided working estimates of human radiation tolerance of variable accuracy. Their inaccuracy results from the fact that in accidents, where normal persons have been irradiated, doses have usually been unknown, whereas in radiotherapy, where doses are known precisely, the additivity of various diseases and cellular abnormalities upon final radiosensitivity remains largely unknown. Even so, from follow-up studies of radiation-accident victims, human radiation biology is not known to be qualitatively different from that of other animals and so the mechanisms of human radiation lethality are sufficiently understood to dictate therapeutic measures and suggest radiation dosage limits for their effectiveness for a few irradiated patients or where large populations are exposed under austere conditions. (author)

  20. Online radiation dose measurement system for ATLAS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Mandic, I.; Cindro, V.; Dolenc, I.; Gorisek, A.; Kramberger, G. [Jozef Stefan Institute, Jamova 39, Ljubljana (Slovenia); Mikuz, M. [Jozef Stefan Institute, Jamova 39, Ljubljana (Slovenia); Faculty of Mathematics and Physics, University of Ljubljana (Slovenia); Bronner, J.; Hartet, J. [Physikalisches Institut, Universitat Freiburg, Hermann-Herder-Str. 3, Freiburg (Germany); Franz, S. [CERN, Geneva (Switzerland)

    2009-07-01

    In experiments at Large Hadron Collider, detectors and electronics will be exposed to high fluxes of photons, charged particles and neutrons. Damage caused by the radiation will influence performance of detectors. It will therefore be important to continuously monitor the radiation dose in order to follow the level of degradation of detectors and electronics and to correctly predict future radiation damage. A system for online radiation monitoring using semiconductor radiation sensors at large number of locations has been installed in the ATLAS experiment. Ionizing dose in SiO{sub 2} will be measured with RadFETs, displacement damage in silicon in units of 1-MeV(Si) equivalent neutron fluence with p-i-n diodes. At 14 monitoring locations where highest radiation levels are expected the fluence of thermal neutrons will be measured from current gain degradation in dedicated bipolar transistors. The design of the system and tests of its performance in mixed radiation field is described in this paper. First results from this test campaign confirm that doses can be measured with sufficient sensitivity (mGy for total ionizing dose measurements, 10{sup 9} n/cm{sup 2} for NIEL (non-ionizing energy loss) measurements, 10{sup 12} n/cm{sup 2} for thermal neutrons) and accuracy (about 20%) for usage in the ATLAS detector

  1. Online radiation dose measurement system for ATLAS experiment

    International Nuclear Information System (INIS)

    Mandic, I.; Cindro, V.; Dolenc, I.; Gorisek, A.; Kramberger, G.; Mikuz, M.; Bronner, J.; Hartet, J.; Franz, S.

    2009-01-01

    In experiments at Large Hadron Collider, detectors and electronics will be exposed to high fluxes of photons, charged particles and neutrons. Damage caused by the radiation will influence performance of detectors. It will therefore be important to continuously monitor the radiation dose in order to follow the level of degradation of detectors and electronics and to correctly predict future radiation damage. A system for online radiation monitoring using semiconductor radiation sensors at large number of locations has been installed in the ATLAS experiment. Ionizing dose in SiO 2 will be measured with RadFETs, displacement damage in silicon in units of 1-MeV(Si) equivalent neutron fluence with p-i-n diodes. At 14 monitoring locations where highest radiation levels are expected the fluence of thermal neutrons will be measured from current gain degradation in dedicated bipolar transistors. The design of the system and tests of its performance in mixed radiation field is described in this paper. First results from this test campaign confirm that doses can be measured with sufficient sensitivity (mGy for total ionizing dose measurements, 10 9 n/cm 2 for NIEL (non-ionizing energy loss) measurements, 10 12 n/cm 2 for thermal neutrons) and accuracy (about 20%) for usage in the ATLAS detector

  2. Estramustine: A novel radiation enhancer in human carcinoma cells

    International Nuclear Information System (INIS)

    Ryu, S.; Gabel, M.; Khil, M.S.

    1994-01-01

    Estramustine (EM), an antimicrotubule agent, binds microtubule-associated proteins, causes spindle disassembly, and arrests cells at the late G 2 /M phase of the cell cycle. Since cells in the G 2 /M phase are the most radiosensitive and some human cancer cells contain high level of EM-binding protein, experiments were carried out to determine whether radiation sensitization could be obtained in human carcinoma cells. Cells containing a high level of EM-binding protein such as prostate carcinoma (DU-145), breast carcinoma (MCF-7), and malignant glioma (U-251) were used to demonstrate radiosensitization. Cervical carcinoma (HeLa-S 3 ) and colon carcinoma (HT-29) cells which are not known to contain EM-binding protein were also employed. Cell survival was assayed by the colony forming ability of single plated cells in culture to obtain dose-survival curves. Pretreatment of DU-145, MCF-7, and U-251 cells to a nontoxic concentration (5 μM) of EM for more than one cell cycle time, substantially enhanced the radiation-induced cytotoxicity. The sensitizer enhancement ratio of these cells ranged from 1.35-1.52. The magnitude of the enhancement was dependent on the drug concentration and exposure time. The rate of cell accumulation in G 2 /M phase, as determined by flow cytometry, increased with longer treatment time in the cell lines which showed radiosensitization. Other antimicrotubule agents such as taxol and vinblastine caused minimal or no radiosensitization at nontoxic concentrations. The data provide a radiobiological basis for using EM as a novel radiation enhancer, with the property of tissue selectivity. 29 refs., 4 figs., 1 tab

  3. The Ubiquity of Humanity and Textuality in Human Experience

    Directory of Open Access Journals (Sweden)

    Daihyun Chung

    2015-11-01

    Full Text Available The so-called “crisis of the humanities” can be understood in terms of an asymmetry between the natural and social sciences on the one hand and the humanities on the other. While the sciences approach topics related to human experience in quantificational or experimental terms, the humanities turn to ancient, canonical, and other texts in the search for truths about human experience. As each approach has its own unique limitations, it is desirable to overcome or remove the asymmetry between them. The present article seeks to do just that by advancing and defending the following two claims: (a that humanity is ubiquitous wherever language is used; and (b that anything that can be experienced by humans is in need of an interpretation. Two arguments are presented in support of these claims. The first argument concerns the nature of questions, which are one of the fundamental marks or manifestations of human language. All questions are ultimately attempts to find meanings or interpretations of what is presented. As such, in questioning phenomena, one seeks to transcend the negative space or oppression of imposed structures; in doing so, one reveals one’s humanity. Second, all phenomena are textual in nature: that which astrophysicists find in distant galaxies or which cognitive neuroscientists find in the structures of the human brain are no less in need of interpretation than the dialogues of Plato or the poems of Homer. Texts are ubiquitous. The implications of these two arguments are identified and discussed in this article. In particular, it is argued that the ubiquity of humanity and textuality points to a view of human nature that is neither individualistic nor collectivist but rather integrational in suggesting that the realization of oneself is inseparable from the realization of others.

  4. Belgian experience with radiation technologies for sterilization

    International Nuclear Information System (INIS)

    Bonet, H.; Dardenne, P.; Herier, A.

    1998-01-01

    Belgium pioneered in non energetic applications of nuclear science. In 1970, the National Institute for Radioisotopes (IRE) was founded on the ground of the experience acquired at the CEN/SCK, for developing nuclear techniques oriented to the well-being of population. In 1978 IRE started operation of 2 γ-irradiation units with a 2.25 million Ci Co 60 , source having a capacity for sterilization of more than 100 m 3 of product per day. this installation is currently operated by Griffith-Mediris (Group Griffith Micro Science) and has accumulated 20 years of experience for irradiation of foodstuffs, medical appliances and pharmaceuticals. In 1986, IRE was producing radioisotopes from accelerators and joined UCL for founding Ion Beam Applications (IBA) company which shortly became the world leader for design and delivery of cyclotrons. More recently, on the basis of French CEA patent, IBA developed the Rhodotron, an e-beam accelerator, with an X-ray option, which is now facing commercial success i area of ionization of food and medical appliances. IRE developed also expertise for the back-end of these activities i.e. final disposal of radioactive sealed source and dismantling of the installations. (author)

  5. EV M-experiment in radiation material science

    International Nuclear Information System (INIS)

    Ganeev, G.Z.; Kislitsin, S.B.; Pyatiletov, Yu.S.; Turkebaev, T.Eh.; Tyupkina, O.G.

    1999-01-01

    To simulate rapid processes in materials, rearrangement at the atomic level, or processes in which the access to the materials is limited or considered to be hazardous, the EV M-experiment is going to be applied more often in the atomic material science (calculating experiment, computer-aided simulation). This paper presents the most important outcomes obtained from the calculating experiment carried out by scientists of the Institute of Nuclear Physics of NNC RK, who are considered to be followers of the scientific school named after Kirsanov V.V. The review consists of the following sections: 1. Simulation of dynamic processes of radiation damage of materials. 2. Simulation of radiation defects in materials. 3. Simulation of radiation defects migration processes in crystals. 4. Simulation of irradiated materials failure and deformation processes

  6. Low dose radiation enhance the anti-tumor effect of high dose radiation on human glioma cell U251

    International Nuclear Information System (INIS)

    Wang Chang; Wang Guanjun; Tan Yehui; Jiang Hongyu; Li Wei

    2008-01-01

    Objective: To detect the effect on the growth of human glioma cell U251 induced by low dose irradiation and low dose irradiation combined with large dose irradiation. Methods: Human glioma cell line U251 and nude mice carried with human glioma were used. The tumor cells and the mice were treated with low dose, high dose, and low dose combined high dose radiation. Cells growth curve, MTT and flow cytometry were used to detect the proliferation, cell cycle and apoptosis of the cells; and the tumor inhibition rate was used to assess the growth of tumor in vivo. Results: After low dose irradiation, there was no difference between experimental group and control group in cell count, MTT and flow cytometry. Single high dose group and low dose combined high dose group both show significantly the suppressing effect on tumor cells, the apoptosis increased and there was cell cycle blocked in G 2 period, but there was no difference between two groups. In vivo apparent anti-tumor effect in high dose radiation group and the combining group was observed, and that was more significant in the combining group; the prior low dose radiation alleviated the injury of hematological system. There was no difference between single low dose radiation group and control. Conclusions: There is no significant effect on human glioma cell induced by low dose radiation, and low dose radiation could not induce adaptive response. But in vivo experience, low dose radiation could enhance the anti-tumor effect of high dose radiation and alleviated the injury of hematological system. (authors)

  7. Establishment of a national radiation protection infrastructure. The Philippine experience

    Energy Technology Data Exchange (ETDEWEB)

    Valdezco, E.M. [Philippine Nuclear Research Institute, Department of Science and Technology (Philippines)

    2000-05-01

    Radiation and radioactive materials have been used widely in the Philippines for the last four decades and have made substantial contributions to the improvement of the life and welfare of the Filipino people. In spite of the unsuccessful attempt to operate a nuclear power, plant, the country, through the Philippine Nuclear Research Institute has consistently pursued an active small nuclear applications program to promote the peaceful applications of nuclear energy while also mandated to ensure radiation safety through nuclear regulations and radioactive materials licensing. Another government agency, the Radiation Health Services (RHS) of the Department of Health was created much later to address the growing concern on radiation hazards from electrically generated radiation devices and machines. The RHS has been strengthened later to include non-ionizing radiation health hazards and has expanded to include a biomedical engineering and non-radiation related medical equipment. The paper will describe the historical perspective highlighting the basis of the national regulatory framework to ensure that only qualified individuals are authorized to use radioactive materials and radiation emitting machines/devices. The development of national training programs in radiation protection and experiences in implementing these programs will be presented. National efforts to strengthen the radiation protection infrastructure through the establishment, improvement and upgrading of a number of facilities and capabilities in radiation protection related work activities will be discussed including participation in national, regional and international intercomparison programs to ensure accuracy, reliability, reproducibility and comparability of dose measurements. Lastly, data on the status of small nuclear applications and related activities in the country will be presented including a number of current issues related to the adoption of the new international basic safety standards

  8. Establishment of a national radiation protection infrastructure. The Philippine experience

    International Nuclear Information System (INIS)

    Valdezco, E.M.

    2000-01-01

    Radiation and radioactive materials have been used widely in the Philippines for the last four decades and have made substantial contributions to the improvement of the life and welfare of the Filipino people. In spite of the unsuccessful attempt to operate a nuclear power, plant, the country, through the Philippine Nuclear Research Institute has consistently pursued an active small nuclear applications program to promote the peaceful applications of nuclear energy while also mandated to ensure radiation safety through nuclear regulations and radioactive materials licensing. Another government agency, the Radiation Health Services (RHS) of the Department of Health was created much later to address the growing concern on radiation hazards from electrically generated radiation devices and machines. The RHS has been strengthened later to include non-ionizing radiation health hazards and has expanded to include a biomedical engineering and non-radiation related medical equipment. The paper will describe the historical perspective highlighting the basis of the national regulatory framework to ensure that only qualified individuals are authorized to use radioactive materials and radiation emitting machines/devices. The development of national training programs in radiation protection and experiences in implementing these programs will be presented. National efforts to strengthen the radiation protection infrastructure through the establishment, improvement and upgrading of a number of facilities and capabilities in radiation protection related work activities will be discussed including participation in national, regional and international intercomparison programs to ensure accuracy, reliability, reproducibility and comparability of dose measurements. Lastly, data on the status of small nuclear applications and related activities in the country will be presented including a number of current issues related to the adoption of the new international basic safety standards

  9. Some human-related problems in radiation protection

    International Nuclear Information System (INIS)

    Yoshizawa, Yasuo

    1980-01-01

    Radiation protection includes both human and source-related problems. The human problems have not only medical but also social aspects, such as labor management. Special attention should be paid to the fact that the subject of radiation protection is not a human being as living thing but as member of society. ICRP recommended that conditions of work can be divided into two classed, working condition A and B, according to annual exposure. This application is of great value to radiation protection practice. Nevertheless the legal regulations do not adopt it yet. The present condition of the medical surveillance of radiation workers is not appropriate from the scientific standpoint. This is the difficult problem which is caused by the delay of the legal application of ICRP recommendation. Compensation for occupational radiation hazards should be overlooked. This problem have been investigated by an authorized committee, but a number of unsolved problems still remain. (author)

  10. Radiation response of haematopoietic cell lines of human origin

    International Nuclear Information System (INIS)

    Lehnert, S.; Rybka, W.B.; Suissa, S.; Giambattisto, D.

    1986-01-01

    Six human haematopoietic cell lines, five of leukaemic origin, including cells with myeloid, lymphoid and undifferentiated phenotype have been studied with respect to radiation response. The intrinsic radio-sensitivity of the cells varied widely, the D 0 s ranging from 0.53 to 1.39 Gy. Five of the cell lines showed some capacity to accumulate sublethal damage; in three of these, enhanced survival was demonstrated in split-dose experiments. One cell line (HL-60) was anomalous in that although little accumulation of sublethal damage was demonstrable, survival was enhanced by fractionation of the dose. Five of the six cell lines studied were of leukaemic origin. The results support the belief that, in contrast to the almost constant radiosensitivity of normal haematopoietic cell progenitors, leukaemic cell progenitors may show a wide range of radiosensitivities. (author)

  11. Biological effect of radiation on human

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yun Sil; Cho, Chul Koo; Lee, Su Jae [and others

    2000-04-01

    1. Adaptive response when 0.01 Gy was preirradiated before high challenging dose is induced in normal cell types such normal lymphocytes, primary keratinocytes, and L929 fibroblast cells but not in neoplastic cells such as L5178Y lymphoma cells, EL-4 lymphoma cells and 308 papilloma cells. 2. Heat shock protein (HSP) 25 and inducible HSP70 is responsible for the induction of adaptive response and radioresistance - cell cycle regulation, antiapoptotic molecule and PKC activation were involved. 3. Apoptosis was induced at most 5. hrs after irradiation in primary keratinocytes, in v-rasHa transformed keratinocytes, the maximum interval was 16 hrs, and in 308 papilloma cells, the maximum was 48 hrs. 4. PKC response by radiation is correlated with induction of apoptosis. 5. Rapid induction PKCdelta in primary keratinocytes and no response of PKC epsilon may involved in radiation induced apoptosis. 6. The rate of resorption was increased when radiation was given at 2.5 days after gestation. Early death including foetal death were highly expressed when radiation was given at 7.5 days after gestation. There are no difference in incidence of late death including embryonic death. 7. 2 Gy is the most effective dose in radiation induced teratogenesis in mouse model. 8. Growth retardation and small head was present when radiation was given at 5.5, 7.5, 11.5 and 15.5 days after gestation and small head showed high incidence at 11.5 days after gestation. 9. External malformation, internal malformation and skeletal malformation was induced when radiation was given at 7.5 days after gestation. 10. OGG1-mutated cells induced radiosensitive by G2/M cell cycle arrest. 11. Radiation induced G2/M phase cell cycle and correlated with radiosensitivity. 12. PKCalpha induced differentiation. 13. Radiation exposed cells showed carcinogenic effect. 14. Organ specific radiosensitivity was shown and protein expression was involved.

  12. Biological effect of radiation on human

    International Nuclear Information System (INIS)

    Lee, Yun Sil; Cho, Chul Koo; Lee, Su Jae

    2000-04-01

    1. Adaptive response when 0.01 Gy was preirradiated before high challenging dose is induced in normal cell types such normal lymphocytes, primary keratinocytes, and L929 fibroblast cells but not in neoplastic cells such as L5178Y lymphoma cells, EL-4 lymphoma cells and 308 papilloma cells. 2. Heat shock protein (HSP) 25 and inducible HSP70 is responsible for the induction of adaptive response and radioresistance - cell cycle regulation, antiapoptotic molecule and PKC activation were involved. 3. Apoptosis was induced at most 5. hrs after irradiation in primary keratinocytes, in v-rasHa transformed keratinocytes, the maximum interval was 16 hrs, and in 308 papilloma cells, the maximum was 48 hrs. 4. PKC response by radiation is correlated with induction of apoptosis. 5. Rapid induction PKCdelta in primary keratinocytes and no response of PKC epsilon may involved in radiation induced apoptosis. 6. The rate of resorption was increased when radiation was given at 2.5 days after gestation. Early death including foetal death were highly expressed when radiation was given at 7.5 days after gestation. There are no difference in incidence of late death including embryonic death. 7. 2 Gy is the most effective dose in radiation induced teratogenesis in mouse model. 8. Growth retardation and small head was present when radiation was given at 5.5, 7.5, 11.5 and 15.5 days after gestation and small head showed high incidence at 11.5 days after gestation. 9. External malformation, internal malformation and skeletal malformation was induced when radiation was given at 7.5 days after gestation. 10. OGG1-mutated cells induced radiosensitive by G2/M cell cycle arrest. 11. Radiation induced G2/M phase cell cycle and correlated with radiosensitivity. 12. PKCalpha induced differentiation. 13. Radiation exposed cells showed carcinogenic effect. 14. Organ specific radiosensitivity was shown and protein expression was involved

  13. Radiation -- A Cosmic Hazard to Human Habitation in Space

    Science.gov (United States)

    Lewis, Ruthan; Pellish, Jonathan

    2017-01-01

    Radiation exposure is one of the greatest environmental threats to the performance and success of human and robotic space missions. Radiation permeates all space and aeronautical systems, challenges optimal and reliable performance, and tests survival and survivability. We will discuss the broad scope of research, technological, and operational considerations to forecast and mitigate the effects of the radiation environment for deep space and planetary exploration.

  14. Administration of ionizing radiation to human subjects in medical research

    International Nuclear Information System (INIS)

    1985-01-01

    Any administration of ionizing radiation to human subjects for the purposes of diagnostic or therapeutic research involving either irradiation or the administration of radionuclides, should be undertaken only after approval by an institutional ethics committee. The ethics committee should obtain advice from a person experienced in radiation protection before granting approval. The research proposal must conform to regulatory requirements relating to the use of ionizing radiation

  15. Effects of low levels of radiation on humans

    International Nuclear Information System (INIS)

    Auxier, J.A.

    1981-01-01

    The state of knowledge on effects of low-level ionizing radiations on humans is reviewed. Several problems relating to dose thresholds or lack of thresholds for several types of cancer and high LET radiations and the effects of fractionation and dose protection are discussed

  16. Human · mouse genome analysis and radiation biology. Proceedings

    International Nuclear Information System (INIS)

    Hori, Tada-aki

    1994-03-01

    This issue is the collection of the papers presented at the 25th NIRS symposium on Human, Mouse Genome Analysis and Radiation Biology. The 14 of the presented papers are indexed individually. (J.P.N.)

  17. Natural radiation exposure modified by human activities

    International Nuclear Information System (INIS)

    Fujimoto, Kenzo

    1995-01-01

    We are now living in the radiation environment modified by our technology. It is usually called 'Technologically Enhanced Natural Radiation' and have been discussed in the UNSCEAR Reports as an important source of exposure. The terrestrial radionuclide concentrations as well as the intensity of cosmic rays are considered to have been constant after our ancestors came down from trees and started walking on their two feet. However, we have been changing our environment to be more comfortable for our life and consequently ambient radiation levels are nomore what used to be. In this paper exposures due to natural radiation modified by our following activities are discussed: housing, balneology, cave excursion, mountain climbing, skiing, swimming, smoking and usage of mineral water, well water, coal, natural gas, phosphate rocks and minerals. In the ICRP Publication No. 39, it is clearly mentioned that even natural radiation should be controlled as far as it is controllable. We have to pay more attention to our activities not to enhance the exposure due to unnecessary, avoidable radiation. (author)

  18. Some statistical issues important to future developments in human radiation research

    International Nuclear Information System (INIS)

    Vaeth, Michael

    1991-01-01

    Using his two years experience at the Radiation Effects Research Foundation at Hiroshima, the author tries to outline some of the areas of statistics where methodologies relevant to the future developments in human radiation research are likely to be found. Problems related to statistical analysis of existing data are discussed, together with methodological developments in non-parametric and semi-parametric regression modelling, and interpretation and presentation of results. (Author)

  19. Online Radiation Dose Measurement System for ATLAS experiment

    CERN Document Server

    Mandić, I; The ATLAS collaboration

    2012-01-01

    Particle detectors and readout electronics in the high energy physics experiment ATLAS at the Large Hadron Collider at CERN operate in radiation field containing photons, charged particles and neutrons. The particles in the radiation field originate from proton-proton interactions as well as from interactions of these particles with material in the experimental apparatus. In the innermost parts of ATLAS detector components will be exposed to ionizing doses exceeding 100 kGy. Energetic hadrons will also cause displacement damage in silicon equivalent to fluences of several times 10e14 1 MeV-neutrons per cm2. Such radiation doses can have severe influence on the performance of detectors. It is therefore very important to continuously monitor the accumulated doses to understand the detector performance and to correctly predict the lifetime of radiation sensitive components. Measurements of doses are important also to verify the simulations and represent a crucial input into the models used for predicting future ...

  20. Sample Environment in Experiments using X-Ray Synchrotron Radiation

    DEFF Research Database (Denmark)

    Buras, B

    1984-01-01

    beam experiments with wavelength chosen at will from the continuous spectrum. Another type of insertion device, called undulator produces quasi-monochromatic radiation. The insertion devices enable the tailoring of the emitted S.R. to the requirements of the users and can be treated as the first......Modern electron (positron) storage rings are able to emit very intense X-ray radiation with a continuous spectrum extending to 0.1 A, from bending magnets and insertion devices (wavelength shifters and multipole wigglers). It can be used directly for white beam experiments and/or for monochromatic...... optical element of the beam line. This feature is especially important for experiments with samples in special environment because the latter imposes limitations both on scattering and absorption experiments. However, these limitations can be minimized in each case by finding the best match between...

  1. Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz`s research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments.

  2. Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994

    International Nuclear Information System (INIS)

    1995-05-01

    Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz's research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments

  3. Ionizing radiation decreases human cancer mortality rates

    International Nuclear Information System (INIS)

    Luckey, T.D.

    1997-01-01

    Information from nine studies with exposed nuclear workers and military observers of atmospheric bomb explosions confirms the results from animal studies which showed that low doses of ionizing radiation are beneficial. The usual ''healthy worker effect'' was eliminated by using carefully selected control populations. The results from 13 million person-years show the cancer mortality rate of exposed persons is only 65.6% that of carefully selected unexposed controls. This overwhelming evidence makes it politically untenable and morally wrong to withhold public health benefits of low dose irradiation. Safe supplementation of ionizing radiation should become a public health service. (author)

  4. HAMLET -Human Model MATROSHKA for Radiation Exposure Determination of Astronauts -Current status and results

    Science.gov (United States)

    Reitz, Guenther; Berger, Thomas; Bilski, Pawel; Burmeister, Soenke; Labrenz, Johannes; Hager, Luke; Palfalvi, Jozsef K.; Hajek, Michael; Puchalska, Monika; Sihver, Lembit

    The exploration of space as seen in specific projects from the European Space Agency (ESA) acts as groundwork for human long duration space missions. One of the main constraints for long duration human missions is radiation. The radiation load on astronauts and cosmonauts in space (as for the ISS) is a factor of 100 higher than the natural radiation on Earth and will further increase should humans travel to Mars. In preparation for long duration space missions it is important to evaluate the impact of space radiation in order to secure the safety of the astronauts and minimize their radiation risks. To determine the radiation risk on humans one has to measure the radiation doses to radiosensitive organs within the human body. One way to approach this is the ESA facility MATROSHKA (MTR), under the scientific and project lead of DLR. It is dedicated to determining the radiation load on astronauts within and outside the International Space Station (ISS), and was launched in January 2004. MTR is currently preparing for its fourth experimental phase inside the Japanese Experimental Module (JEM) in summer 2010. MTR, which mimics a human head and torso, is an anthropomorphic phantom containing over 6000 radiation detectors to determine the depth dose and organ dose distribution in the body. It is the largest international research initiative ever performed in the field of space dosimetry and combines the expertise of leading research institutions around the world, thereby generating a huge pool of data of potentially immense value for research. Aiming at optimal scientific exploitation, the FP7 project HAMLET aims to process and compile the data acquired individually by the participating laboratories of the MATROSHKA experiment. Based on experimental input from the MATROSHKA experiment phases as well as on radiation transport calculations, a three-dimensional model for the distribution of radiation dose in an astronaut's body will be built up. The scientific achievements

  5. Health Effects of Non-Ionizing Radiation on Human

    International Nuclear Information System (INIS)

    Zubaidah-Alatas; Yanti Lusiyanti

    2001-01-01

    Increases of development and use of equipment that procedures non-ionizing radiant energy such as laser, radar, microwave ovens, power lines and hand phones, bring about public concern about the possible health effects owing to the non-ionizing radiation exposure. Non ionizing electromagnetic radiation compared to ionizing radiation, has longer wavelength, lower frequency, and lower photon energy in its interaction with body tissues. The term on non-ionizing radiation refers to the groups of electromagnetic radiations with energies less than about 10 eV corresponding to wavelengths in the ultraviolet, visible, infra red microwave and radiofrequency spectral regions. This paper describes the current state of knowledge about types of non-ionizing radiation and the health effects at molecular and cellular levels as well as its effects on human health. (author)

  6. Initial Human Response to Nuclear Radiation

    Science.gov (United States)

    1982-04-01

    symptomatic response to radiation. In the second phase, the models will be used to infer performance effects. DNA staff members Cyrus Knowles and David ...P. Setty ATTN: K. Schwartz ATTN: J. NcGahan Kamn Tempo System Planning Corp ATTN: R. Miller ATTN: J. JonesATTN: G. Perks Kamen Tempo AiT: S. Shrier

  7. Overview of the Radiation Dosimetry Experiment (RaD-X) Flight Mission

    Science.gov (United States)

    Mertens, Christopher J.

    2016-01-01

    The NASA Radiation Dosimetry Experiment (RaD-X) stratospheric balloon flight mission addresses the need to reduce the uncertainty in predicting human exposure to cosmic radiation in the aircraft environment. Measurements were taken that characterize the dosimetric properties of cosmic ray primaries, the ultimate source of aviation radiation exposure, and the cosmic ray secondary radiations that are produced and transported to aviation altitudes. In addition, radiation detectors were flown to assess their potential application to long-term, continuous monitoring of the aircraft radiation environment. RaD-X was successfully launched from Fort Sumner, New Mexico (34.5 N, 104.2 W), on 25 September 2015. Over 18 h of science data were obtained from a total of four different type dosimeters at altitudes above 20 km. The RaD-X flight mission was supported by laboratory radiation exposure testing of the balloon flight dosimeters and also by coordinated radiation measurements taken on ER-2 and commercial aircraft. This paper provides the science background and motivation for the RaD-X flight mission, a brief description of the balloon flight profile and the supporting aircraft flights, and a summary of the articles included in the RaD-X special collection and their contributions to the science goals of the RaD-X mission.

  8. Ultraviolet radiation, human health, and the urban forest

    Science.gov (United States)

    Gordon M. Heisler; Richard H. Grant

    2000-01-01

    Excess exposure to ultraviolet (UV) radiation from the sun, particularly the ultraviolet B (UVB) portion, has been linked with adverse effects on human health ranging from skin cancers to eye diseases such as cataracts. Trees may prevent even greater disease rates in humans by reducing UV exposure. Tree shade greatly reduces UV irradiance when both the sun and sky are...

  9. Undergraduate experiments using the neutron radiation from californium-252

    International Nuclear Information System (INIS)

    Rossel, J.; Golecki, I.

    1976-01-01

    Three experiments designed to demonstrate and measure several properties of the neutron radiation emitted by a 3μg 252 Cf source are described. The experiments constitute a special project carried out by a third-year undergraduate student at the Institute of Physics of the University of Neuchatel. The 252 Cf source is enclosed in a shield which allows a pencil of fast neutrons to pass through a central tube, while reducing the ambient radiation below the tolerance level. The shield consists of layers of borated paraffin wax, iron and cadmium. The first experiment uses an air-alcohol diffusion cloud chamber for the demonstration of tracks of recoil protons produced by the neutrons. Semi-quantitative measurements of track lengths give the correct order of magnitude of the proton energies. In the second experiment a liquid scintillator detector is used to scan the beam profile across the radiation shield enclosing the source. A pulse-shape-discrimination system discriminates between neutrons and gamma photons. The third experiment makes use of the nuclear emulsion technique to study the neutron energy distribution of 252 Cf. Preliminary results are compared with published values. (author)

  10. Porphyrin metabolisms in human skin commensal Propionibacterium acnes bacteria: potential application to monitor human radiation risk.

    Science.gov (United States)

    Shu, M; Kuo, S; Wang, Y; Jiang, Y; Liu, Y-T; Gallo, R L; Huang, C-M

    2013-01-01

    Propionibacterium acnes (P. acnes), a Gram-positive anaerobic bacterium, is a commensal organism in human skin. Like human cells, the bacteria produce porphyrins, which exhibit fluorescence properties and make bacteria visible with a Wood's lamp. In this review, we compare the porphyrin biosynthesis in humans and P. acnes. Also, since P. acnes living on the surface of skin receive the same radiation exposure as humans, we envision that the changes in porphyrin profiles (the absorption spectra and/or metabolism) of P. acnes by radiation may mirror the response of human cells to radiation. The porphyrin profiles of P. acnes may be a more accurate reflection of radiation risk to the patient than other biodosimeters/biomarkers such as gene up-/down-regulation, which may be non-specific due to patient related factors such as autoimmune diseases. Lastly, we discuss the challenges and possible solutions for using the P. acnes response to predict the radiation risk.

  11. Radiation health effects. Experience from Chernobyl to Fukushima

    International Nuclear Information System (INIS)

    Sekitani, Yui; Takamura, Noboru; Yamashita, Shunichi

    2012-01-01

    The accident at the Chernobyl Nuclear Power Plant in 1986 led to a high level of radioactive contamination over wide area in Europe. High radiation-dose exposure to 134 power plant staff and emergency personnel resulted in acute radiation syndrome. The internal radiation exposure by radioactive iodine-131 caused operated thyroid cancer among more than 6000 children at the time of the accident until 2010. The low dose irradiation by radioactive cesium-137 continues even today, and evacuation and relocation proved a deeply traumatic experience to many people. Since the Chernobyl accident, WHO and IAEA have established a global assistance system to strengthen the activities related to radiation emergency medical preparedness and response network. Fukushima Daiichi Nuclear Power Plant accident in 2011 has also caused many people to evacuate, and great suffering, hardship, and anxiety to the residents of Fukushima Prefecture. Therefore the Fukushima Prefectural Government is now conducting the 'The Fukushima Health Management Survey' to alleviate residents' concerns about radiation and to facilitate suitable healthcare in the future. It is necessary to continue scientific research around Chernobyl and provide accurate information on radiation health effects not only to the Fukushima residents but also toward all over the world. (author)

  12. Operating experience on radiation reduction in the latest BWRs

    International Nuclear Information System (INIS)

    Ohsumi, K.; Uchida, S.; Aizawa, M.; Takagi, K.; Amano, O.; Yamashita, K.

    1988-01-01

    In Japan, BWR plants have been operated commercially since 1970, and the reduction of radiation exposure has been an important concern. The application of the procedure for reducing occupational exposure is incorporated in Japanese Improvement and Standardization Program for LWRs. No.2 and No.4 plants in Fukushima No.2 Nuclear Power Station were designed and constructed as the latest 1,100 MWe BWRs in conformity with the Improvement and Standardization Program. No.2 plant began the commercial operation in February, 1984, and experienced three times of the scheduled annual maintenance outage. No.4 plant began the commercial operation in September, 1987, and the first annual maintenance is scheduled from September, 1988. In this paper, discussion is focused on recent radiation reduction measures, that is the control of iron and nickel in primary coolant for reducing the radiation dose rate in primary systems, based on the experience with No.2 and No.4 plants. The design concept of a low radiation dose rate nuclear power plant, the experience on water chemistry in No.2 plant, the control of iron and nickel in No.4 plant operation and so on are reported. It is believed that these operation experiences contribute to the reduction of occupational exposure in BWR plants currently in operation and in future. (Kako, I.)

  13. Experiences of Women Who Donated Human Milk.

    Science.gov (United States)

    Candelaria, Laura M; Spatz, Diane L; Giordano, Noreen

    2018-03-01

    To examine the experiences of women who donated breast milk to a hospital-based milk bank regulated under the policies and procedures set forth by the Human Milk Banking Association of North America (HMBANA). Qualitative, phenomenological design. The Mothers' Milk Bank in a children's hospital in the Northeastern region of the United States. Twelve HMBANA-approved milk donors older than 21 years with infants hospitalized in the NICU. Edmund Husserl's design of interpretive phenomenology and Colaizzi's method of data analysis were used for this study. Participants were interviewed using a face-to-face, semistructured interview format. Four themes represented the experience of donating breast milk: Ripple of Hope and Help, Dynamic Interplay of Nurturance, Standing on the Shoulders of Others, and Sharing Their Stories. Donors felt proud and accomplished to provide hope for other infants and families. Nurses were crucial in facilitating and motivating donors and making donation achievable in a supportive environment. Donors felt compelled to share their experiences to teach and motivate others to donate. For our participants, donation of human milk was a positive, valuable, and nurturing experience. Donors reported feelings of increased self-esteem during donation that motivated them to "give back" and continue. The support of a well-trained nursing staff is essential for donors to meet their personal goals. Copyright © 2018 AWHONN, the Association of Women’s Health, Obstetric and Neonatal Nurses. Published by Elsevier Inc. All rights reserved.

  14. LHCb: Evaluation of the Radiation Environment of the LHCb Experiment

    CERN Multimedia

    Karacson, M

    2011-01-01

    The characterization of all aspects of the radiation field of the LHCb experiment is needed to understand the impact of the unprecedented radiation levels to which its detector and electronics are exposed to. The methodology on how this is done is described. Analysis of the measurements of active and passive sensors of various types which are distributed in and around the detector will be carried out. Appropriate cross calibrations will be applied and comparisons between them will be performed. Critical comparisons with simulation results obtained with the FLUKA Monte Carlo code are also an essential element of the study.

  15. Chinese experience on medical response to radiation emergencies

    International Nuclear Information System (INIS)

    Liu, Ying; Qin, Bin; Lei, Cuiping; Chen, Huifang; Han, Yuhong

    2008-01-01

    Full text: Chinese Center for Medical Response to Radiation Emergency (CCMRRE) was established in 1992, based on the National Institute for Radiological Protection, China CDC (NIRP, China CDC). CCMRRE is a liaison of WHO/REMPAN and functions as a national and professional institute for medical preparedness and response to emergencies involving radioactive material. CCMRRE participates in drafting National Medical Assistant Program for Radiation Emergency and relevant technical documents, develops preventive measures and technique means of medical preparedness and response to radiation emergency. CCMRRE is responsible for medical response to radiological or nuclear accident on national level. CCMRRE holds training courses, organizes drills and provides technical support to local medical organizations in practicing medical preparedness and response to radiation emergency. CCMRRE collects, analyzes and exchanges information on medical response to radiological and nuclear emergency and establishes relevant database. CCMRRE also guides and participates in radiation pollution monitoring on accident sites. In the past ten years, we accumulate much knowledge and experience on medical response to radiation emergencies. In this context, we will discuss Xinzhou Accident, which took place in 1992 and involved in three deaths, and Ha'erbin Accident that took place in 2005 and involved one death. A father and two brothers in Xinzhou Accident died of over-exposed to 60 Co source and misdiagnosis and improper treatment, which indicates that most general practitioners are uncertain about the health consequences of exposure to ionizing radiation and the medical management of exposed patients. When Ha'erbin Accident happened in 2005, the local hospital gave the right diagnosis and treatment based on the clinic symptoms and signs, which prevent more people suffering from over-expose to 192 Ir source. The distinct changes comes from the education and training to primary doctors related

  16. Experience with first aid in radiation sources accidents

    International Nuclear Information System (INIS)

    Klener, V.

    1979-01-01

    More than 20 years of experience at the Radiation Hygiene Centre of the Prague Institute of Hygiene and Epidemiology with prevention of accidents involving sources of radiation and the Centre's participation in providing medical aid in such accidents are described. A list is given of major types of accidents over the past decade. Prevalent were accidents involving sealed gamma sources, resulting in excessive local irradiation with serious skin damage or injury to some of the deeper structures of the hands, requiring plastic operation. Chromosomal picture investigation allows the estimation of the equivalent body dose which only reached higher values in a single case recorded (1.5 Gy = 150 rad). Organisational measures are described for emergencies and the task is shown by radiation hygiene departments attached to regional hygiene stations. The present system is capable of providing adequate, prompt and effective assistance. (author)

  17. Clinical trial experience using erythropoietin during radiation therapy

    International Nuclear Information System (INIS)

    Lavey, R.S.

    1998-01-01

    Oncologists have several reasons for trying to maintain or increase hemoglobin levels in their patients during therapy. Relief of the symptoms of anemia, including fatigue and dyspnea, are traditional, well-accepted indications. A newer rationale is to enhance the efficacy of radiation therapy and/or chemotherapy in controlling tumors. A laboratory animal study found that administration of recombinant human erythropoietin (rHuEPO) increased intratumoral median oxygen levels and diminished the proportion of measurements in the very low ( [de

  18. High energy radiation effects on the human body

    International Nuclear Information System (INIS)

    Kato, Kazuaki

    1977-01-01

    High-energy radiation injuries and their risks were recognized, information on low-energy radiation injuries was also arranged, and with these backgrounds, countermeasures against prevention of radiation injuries were considered. Redintegration of DNA and mutation by radiation were described, and relationship between radiation injuries and dose was considered. Interaction of high-energy radiation and substances in the living body and injuries by the interaction were also considered. Expression method of risk was considered, and a concept of protection dose was suggested. Protection dose is dose equivalent which is worthy of value at the point where the ratio to permissible dose distributed among each part of the body is at its maximum in the distribution of dose equivalent formed within the body when standard human body is placed at a certain radiation field for a certain time. Significance and countermeasures of health examination which is under an abligation to make radiation workers receive health check were thought, and problems were proposed on compensation when radiation injuries should appear actually. (Tsunoda, M.)

  19. Rapid and Decentralized Human Waste Treatment by Microwave Radiation.

    Science.gov (United States)

    Nguyen, Tu Anh; Babel, Sandhya; Boonyarattanakalin, Siwarutt; Koottatep, Thammarat

    2017-07-01

      This study evaluates the technical feasibility of using microwave radiation for the rapid treatment of human feces. Human feces of 1000 g were radiated with a commercially available household microwave oven (with rotation) at different exposure time lengths (30, 50, 60, 70, and 75 mins) and powers (600, 800, and 1000 W). Volume reduction over 90% occurred after 1000 W microwave radiation for 75 mins. Pathogen eradiation performances of six log units or more at a high range of microwave powers were achieved. Treatments with the same energy input of 1000 Wh, but at lower powers with prolonged exposure times, significantly enhanced moisture removal and volume reduction. Microwave radiation caused carbonization and resulted in a more stable end product. The energy content of the samples after microwave treatment at 1000 W and 75 mins is 3517 ± 8.85 calories/g of dried sample, and the product can also be used as compost.

  20. Effects of deprivation of background environmental radiation on cultured human cells

    International Nuclear Information System (INIS)

    Carbone, M.C.; Pinto, M.; Antonelli, F.; Balata, M.

    2010-01-01

    In this paper we present results from an experiment aimed at investigating whether living cells are influenced by background ionizing radiation. Parallel human cell cultures were set-up in two separate laboratories and maintained for several months under identical conditions but for a 80 x different level of background ionizing radiation. Periodically, the cell cultures were monitored for the onset of divergences in biochemical behavior, using two distinct cellular biology assays, namely micronuclei induction and activity of enzymes implicated in the management of oxidative stress. To reveal any subtle modifications, responses were also amplified by subjecting cell cultures to acute stress induced by exposure to moderately high doses of ionizing radiation. Compared to reference radiation background conditions, cultures maintained in a reduced background radiation environment handled the consequences of acute stress with diminished efficacy.

  1. The Radiation Dose-Response of the Human Spinal Cord

    International Nuclear Information System (INIS)

    Schultheiss, Timothy E.

    2008-01-01

    Purpose: To characterize the radiation dose-response of the human spinal cord. Methods and Materials: Because no single institution has sufficient data to establish a dose-response function for the human spinal cord, published reports were combined. Requisite data were dose and fractionation, number of patients at risk, number of myelopathy cases, and survival experience of the population. Eight data points for cervical myelopathy were obtained from five reports. Using maximum likelihood estimation correcting for the survival experience of the population, estimates were obtained for the median tolerance dose, slope parameter, and α/β ratio in a logistic dose-response function. An adequate fit to thoracic data was not possible. Hyperbaric oxygen treatments involving the cervical cord were also analyzed. Results: The estimate of the median tolerance dose (cervical cord) was 69.4 Gy (95% confidence interval, 66.4-72.6). The α/β = 0.87 Gy. At 45 Gy, the (extrapolated) probability of myelopathy is 0.03%; and at 50 Gy, 0.2%. The dose for a 5% myelopathy rate is 59.3 Gy. Graphical analysis indicates that the sensitivity of the thoracic cord is less than that of the cervical cord. There appears to be a sensitizing effect from hyperbaric oxygen treatment. Conclusions: The estimate of α/β is smaller than usually quoted, but values this small were found in some studies. Using α/β = 0.87 Gy, one would expect a considerable advantage by decreasing the dose/fraction to less than 2 Gy. These results were obtained from only single fractions/day and should not be applied uncritically to hyperfractionation

  2. Reduction in life span on normal human fibroblasts exposed to low-dose radiation in heavy-ion radiation field

    International Nuclear Information System (INIS)

    Suzuki, Masao; Yamaguchi, Chizuru; Yasuda, Hiroshi; Uchihori, Yukio; Fujitaka, Kazunobu

    2003-01-01

    We studied the effect of in vitro life span in normal human fibroblasts exposed to chronically low-dose radiation in heavy-ion radiation field. Cells were cultured in a CO 2 incubator, which was set in the irradiation room for biological study of heavy ions in the Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences (NIRS), and exposed to scattered radiations produced with heavy-ion beams throughout the life span of the cell population. Absorbed dose, which was measured using a thermoluminescence dosimeter(TLD) and a Si-semiconductor detector, was to be 1.4 mGy per day when operating the HIMAC machine for biological experiments. The total population doubling number of the exposed cells reduced to 79-93% of non-exposed control cells in the three independent experiments. There is evidence that the exposure of chronically low-dose radiation in heavy-ion radiation field promotes the life-span reduction in cellular level. (author)

  3. Human population exposure to cosmic radiation

    International Nuclear Information System (INIS)

    Bouville, A.; Lowder, W.M.

    1988-01-01

    Critical evaluations of existing data on cosmic radiation in the atmosphere and in interplanetary space have been carried out in order to estimate the exposure of the world's population to this important component of natural background radiation. Data on population distribution and mean terrain heights on a 1 x 1 degree grid have been folded in to estimate regional and global dose distributions. The per caput annual dose equivalent at ground altitudes is estimated to be 270 μSv from charged particles and 50 μSv from neutrons. More than 100 million people receive more than 1 mSv in a year, and two million in excess of 5 mSv. Aircraft flight crews and frequent flyers receive an additional annual dose equivalent in the order of 1 mSv, though the global per caput annual dose equivalent from airplane flights is only about 1 μSv. Future space travellers on extended missions are likely to receive dose equivalents in the range 0.11 Sv, with the possibility of higher doses at relatively high dose rates from unusually large solar flares. These results indicate a critical need for a better understanding of the biological significance of chronic neutron and heavy charged particle exposure. (author)

  4. Mathematical models for radiation effects on human health

    International Nuclear Information System (INIS)

    Negi, U.S.; Petwal, K.C.

    2015-01-01

    In this paper, we are proposing a theoretical approach of basic mathematical models for radiation effect on human health. The largest natural sources of radiation exposure to humans are radon gas. While radon gas has always been in the environment, awareness of its contribution to human radiation exposure has increased in recent years. Radon's primary pathway is through air space in soil and rock. Pressure differences between the soil and the inside of buildings may cause radon gas to move indoors. Radon decays to radon daughters, some of which emit alpha radiation. Alpha-emitting radon daughters are adsorbed on to dust particles which, when inhaled, are trapped in the lungs and may cause gene damage, mutations and finally cancer. Exposure to excess UV radiation increases risk of skin cancer but there is also a dark side. The incidence of all types of skin cancer is related to exposure to UV radiation. Non-melanoma skin cancer, eye melanoma, and lip cancer have also been related to natural UV light

  5. Chronic effects of ionizing radiation on animals and humans

    International Nuclear Information System (INIS)

    Drozd, Yi.P.

    2013-01-01

    Numerous experimental radiobiological studies and medical observations were conducted after the Chernobyl disaster based on the published results; patterns and characteristics influence of the fission products of nuclear materials on the body of mammals, including humans were analyzed. Chronic exposure to low doses leads to the changes in the hemopoietic system was founded and increases the risk of myeloproliferative diseases. The consequence of radiation-related immunodeficiency is the autoimmune disease and chronic fatigue syndrome. Radiation damage leads to endocrine system disruption of the body and of polipatologycal states. High radiosensitivity of the central nervous system was founded. Genotoxic chronic radiation exposure threatens the stability of the genome

  6. A consideration of low dose radiation effects on human health

    International Nuclear Information System (INIS)

    Shimada, Yoshiya; Nishimura, Mayumi; Imaoka, Tatsuhiko; Kakinuma, Shizuko

    2011-01-01

    On March 11, 2011, an earthquake categorized as 9 Mw occurred off the northeast coast of Japan. The subsequent destructive tsunami disabled emergency units of Fukushima Dai'ichi Nuclear Power Plant and caused partial meltdown of reactors and explosions. Resulting radiation releases forced large evacuations, bore concerns about food and water and fears against human health. In this manuscript, we described the effect of radiation, especially low dose radiation below 100 mSv, on cancer risk, focusing on fetuses and children. (author)

  7. Radiation protection for human spaceflight; Strahlenschutz in der bemannten Weltraumfahrt

    Energy Technology Data Exchange (ETDEWEB)

    Hajek, M. [Atominstitut, Technische Univ. Wien (Austria)

    2009-07-01

    Cosmic radiation exposure is one of the most significant risks associated with human space exploration. Except for the principles of justification and optimization (ALARA), the concepts of terrestrial radiation protection are of limited applicability to human spaceflight, as until now only few experimentally verified data on the biological effectiveness of heavy ions and the dose distribution within the human body exist. Instead of applying the annual dose limits for workers on ground also to astronauts, whose careers are of comparatively short duration, the overall lifetime risk is used as a measure. For long-term missions outside Earth's magnetic field, the acceptable level of risk has not yet been defined, since there is not enough information available to estimate the risk of effects to the central nervous system and of potential non-cancer radiation health hazards. (orig.)

  8. The research of nuclear experiment radiation environment wireless alarm device

    International Nuclear Information System (INIS)

    Wang Xiaoqiong; Wang Pan; Fang Fang

    2009-01-01

    This article introduces based on monolithic integrated circuit's nuclear experiment radiation environment wireless alarm device's software and hardware design. The system by G-M tube, high-pressured module, signal conditioning circuit, power source module, monolithic integrated circuit and wireless transmission module is composed. The device has low power consumption, high performance, high accuracy detection, easy maintenance, small size, simple operation, and other features, and has a broad application prospects. (authors)

  9. Experiments planned to be made with the synchrotron radiation source

    International Nuclear Information System (INIS)

    Matz, W.

    1993-01-01

    For this working meeting, various research groups from the Land Sachsen and from the neighbouring countries Poland and the Czech Republic have been invited in order to present their materials research programmes or task-specific experiments intended to be carried out with the synchrotron radiation source to be installed in the near future. The proceedings volume in hand presents the discussion papers, which have been directly reproduced from the original foils. (orig.) [de

  10. Ultraviolet radiation directly induces pigment production by cultured human melanocytes

    International Nuclear Information System (INIS)

    Friedmann, P.S.; Gilchrest, B.A.

    1987-01-01

    In humans the major stimulus for cutaneous pigmentation is ultraviolet radiation (UVR). Little is known about the mechanism underlying this response, in part because of the complexity of interactions in whole epidermis. Using a recently developed culture system, human melanocytes were exposed daily to a physiologic range of UVR doses from a solar simulator. Responses were determined 24 hours after the last exposure. There was a dose-related increase in melanin content per cell and uptake of 14 C-DOPA, accompanied by growth inhibition. Cells from donors of different racial origin gave proportionately similar increases in melanin, although there were approximately tenfold differences in basal values. Light and electron microscopy revealed UVR-stimulated increases in dendricity as well as melanosome number and degree of melanization, analogous to the well-recognized melanocyte changes following sun exposure of intact skin. Similar responses were seen with Cloudman S91 melanoma cells, although this murine cell line required lower UVR dosages and fewer exposures for maximal stimulation. These data establish that UVR is capable of directly stimulating melanogenesis. Because cyclic AMP elevation has been associated in some settings with increased pigment production by cultured melanocytes, preliminary experiments were conducted to see if the effects of UVR were mediated by cAMP. Both alpha-MSH and isobutylmethylxanthine (IBMX), as positive controls, caused a fourfold increase in cAMP level in human melanocytes and/or S91 cells, but following a dose of UVR sufficient to stimulate pigment production there was no change in cAMP level up to 4 hours after exposure. Thus, it appears that the UVR-induced melanogenesis is mediated by cAMP-independent mechanisms

  11. Chromosome Aberrations in Human Lymphocytes Irradiated with Ionizing Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Tae Ho; Kim, Jin Hong; Kim, Jin Kyu [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    The purpose of the present experiment was to provide data on the dose-dependent production of chromosome aberrations such as dicentrics, centric rings, and excess acentrics. Radiation is one of the more dangerous clastogens in the environment. Ionizing radiation causes chromosome breakages and various cytogenetic aberrations in exposed cells. In an investigation into radiation emergencies, it is important to estimate the dose to exposed persons for several reasons. Physical dosimeters (e. g., film badges) may misrepresent the actual radiation dose and may not be available in a radiological accident or terrorism incident. Biological dosimetry is suitable for estimating the radiation dose during such accidents. The dicentric chromosome assay is very sensitive and a reliable bio-indicator in cases of accidental overexposure.

  12. Human health and exposure to electromagnetic radiation

    International Nuclear Information System (INIS)

    Dennis, J.A.; Muirhead, C.R.; Ennis, J.R.

    1992-07-01

    This review consists of three main parts. In the first the general features of electromagnetic fields and their interactions with the human body are described. The second part deals with the epidemiological evidence for effects on general health and birth outcome. The third part describes the epidemiological evidence from occupational and residential studies of a possible association between electromagnetic field exposures and cancer. (author)

  13. The radiation response of human dermal fibroblasts

    Science.gov (United States)

    Mitchell, Stephen Andrew

    A clinically reliable predictive assay based on normal-tissue radiosensitivity may lead to improved tumour control through individualised dose prescriptions. In-vitro fibroblast radiosensitivity has been shown, in several studies, to correlate with late radiation morbidity. The aim of this study was to investigate some of the cellular mechanisms underlying the normal-tissue response. In this study, seventeen primary fibroblast strains were established by enzymatic disaggregation of skin biopsies obtained from patients. These comprised seven who experienced acute tissue reactions to radiotherapy, four patients with a normal response and six non-cancer volunteers. An AT cell line was included as a positive control for radiosensitivity. In-vitro radiosensitivity was measured using a clonogenic assay at both high (HDR: 1.6 Gymin-1) and low dose rate (LDR: 0.01 Gymin-1). The radiation parameter HDR SF2 was the most sensitive in discriminating the seven sensitive patients from the remaining ten normal patients (range 0.11-0.19 sensitive patients compared with 0.17-0.34 control patients: puse of an internal control or LDR radiation protocol increased this discrimination. Pulsed-field gel electrophoresis (PFGE) was used to measure the level of initial and residual double-strand breaks following irradiation. No correlation was found between HDR SF2 and initial DNA damage. However, a strong correlation was found between clonogenic survival and both residual DNA damage (measured over 10-70 Gy, allowing 4 h repair, correlation coefficient: 0.90, <0.0001) and the ratio of residual/initial DNA damage, with the sensitive cell lines generally showing a higher level of residual DNA damage. Cell-cycle delays were found in all 18 cell strains in response to 2 Gy irradiation, but were not found to discriminate between sensitive and normal patients. Associated studies found no mutations of the ATM gene in the five radiosensitive patients studied. However, a coding sequence alteration

  14. Urban pollution by electromagnetic radiation. What risk for human health?

    International Nuclear Information System (INIS)

    Bressa, G.

    1999-01-01

    Power lines, domestic appliances, radios, TV sets, cell-phones, radar, etc., they are all instruments which, entering our everyday life, cause electromagnetic pollution. The risks for human health as a consequence of being exposed to this kind of radiation haven't been clearly ascertained yet, even if there is proof of the connection between the onset of some tumoral forms and exposure to electromagnetic fields. Many countries, among which Italy, are tackling the problem of safety distances, necessary to reduce exposure to non-ionising radiation, by issuing bills suitable for human health protection [it

  15. Human Genetic Marker for Resistance to Radiation and Chemicals

    International Nuclear Information System (INIS)

    Lieberman, Howard B.

    2001-01-01

    TO characterize the human HRDAD9 gene and evaluate its potential as a biomarker to predict susceptibility to the deleterious health effects potentially caused by exposure to radiations or chemicals present at DOE hazardous waste cleanup sites. HRAD9 is a human gene that is highly conserved throughout evolution. Related genes have been isolated from yeasts and mice, underscoring its biological significance. Most of our previous work involved characterization of the yeast gene cognate, wherein it was determined that the corresponding protein plays a significant role in promoting resistance of cells to radiations and chemicals, and in particular, controlling cell growth in response to DNA damage

  16. Australia's proactive approach to radiation protection of the environment: how integrated is it with radiation protection of humans?

    Science.gov (United States)

    Hirth, G A; Grzechnik, M; Tinker, R; Larsson, C M

    2018-01-01

    Australia's regulatory framework has evolved over the past decade from the assumption that protection of humans implies protection of the environment to the situation now where radiological impacts on non-human species (wildlife) are considered in their own right. In an Australian context, there was a recognised need for specific national guidance on protection of non-human species, for which the uranium mining industry provides the major backdrop. National guidance supported by publications of the Australian Radiation Protection and Nuclear Safety Agency (Radiation Protection Series) provides clear and consistent advice to operators and regulators on protection of non-human species, including advice on specific assessment methods and models, and how these might be applied in an Australian context. These approaches and the supporting assessment tools provide a mechanism for industry to assess and demonstrate compliance with the environmental protection objectives of relevant legislation, and to meet stakeholder expectations that radiological protection of the environment is taken into consideration in accordance with international best practice. Experiences from the past 5-10 years, and examples of where the approach to radiation protection of the environment has been well integrated or presented some challenges will be discussed. Future challenges in addressing protection of the environment in existing exposure situations will also be discussed.

  17. The human experience with intravenous levodopa

    Directory of Open Access Journals (Sweden)

    Shan H Siddiqi

    2016-01-01

    Full Text Available Objective: To compile a comprehensive summary of published human experience with levodopa given intravenously, with a focus on information required by regulatory agencies.Background: While safe intravenous (IV use of levodopa has been documented for over 50 years, regulatory supervision for pharmaceuticals given by a route other than that approved by the U.S. Food and Drug Administration (FDA has become increasingly cautious. If delivering a drug by an alternate route raises the risk of adverse events, an investigational new drug (IND application is required, including a comprehensive review of toxicity data.Methods: Over 200 articles referring to IV levodopa were examined for details of administration, pharmacokinetics, benefit and side effects.Results: We identified 142 original reports describing IVLD use in humans, beginning with psychiatric research in 1959-1960 before the development of peripheral decarboxylase inhibitors. Over 2750 subjects have received IV levodopa, and reported outcomes include parkinsonian signs, sleep variables, hormone levels, hemodynamics, CSF amino acid composition, regional cerebral blood flow, cognition, perception and complex behavior. Mean pharmacokinetic variables were summarized for 49 healthy subjects and 190 with Parkinson’s disease. Side effects were those expected from clinical experience with oral levodopa and dopamine agonists. No articles reported deaths or induction of psychosis.Conclusion: Over 2750 patients have received IV levodopa with a safety profile comparable to that seen with oral administration.

  18. Medical modification of human acute radiation injury

    International Nuclear Information System (INIS)

    Wald, N.; Watson, J.A.

    1977-01-01

    In weighing the benefits and risks of utilizing nuclear energy, there must be a continuing reassessment as nuclear technology develops and changes. The health effects of radiation accidents, as most important part of the risk, must also be reevaluated as our medical ability grows to modify and ameliorate the consequences. The therapeutic efforts were classified as minimal, supportive or heroic. Supportive treatment included reverse isolation, detailed clinical laboratory measurements copious antibiotics, and transfusions of various blood cells, electrolytes and nutrients. Heroic treatment added bone marrow transplantation, while minimal treatment included none of these. It was concluded that while the LD 50 for man is about 340 rads with only minimal treatment, it could be increased to 510 rads with supportive therapy and to over 1,000 rads with heroic treatment. Hematopoietic injury predominated in this exposure range. Finally an estimate of the medical facilities available in the United States to meet these potential clinical needs was made. The relationship of the medical care resources to the likely needs following a serious nuclear power plant accident will be discussed

  19. Human radiation studies: Remembering the early years: Oral history of radiation biologist Marvin Goldman, Ph.D., conducted December 22, 1994

    International Nuclear Information System (INIS)

    1995-09-01

    This report provides a transcript of an interview of Dr. Marvin Goldman by representatives of DOE's Office of Human Radiation Experiments. Dr. Goldman was chosen for this interview because of his work on bone-seeking radionuclides. After a brief biographical sketch Dr. Goldman related his experiences concerning his training and work at Rochester University, his work at Brookhaven National Laboratory, his participation in the Beagle Studies at University of California at Davis, his work with the Chernobyl Nuclear Plant Accident, his consultation work with Russian authorities on the health and ecological effects in their history, and finally his opinions and recommendations on human radiation research and the environmental cleanup of DOE sites

  20. The transition radiation detector of the CBM experiment at FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Bergmann, Cyrano [Institut fuer Kernphysik, WWU Muenster (Germany)

    2016-07-01

    The Compressed Baryonic Matter (CBM) experiment is a fixed target heavy-ion experiment at the future FAIR accelerator facility. The CBM Transition Radiation Detector (TRD) is one of the key detectors to provide electron identification above momenta of 1 GeV/c and charged particle tracking. Due its capability to identify charged particles via their specific energy loss, the TRD in addition will provide valuable information for the measurement of fragments. These requirements can be fulfilled with a XeCO{sub 2} based Multi-Wire Proportional Counter (MWPC) detector in combination with an adequate radiator. The default MWPC is composed of a symmetric amplification area of 7 mm thickness, followed by a 5 mm drift region to enhance the TR-photon absorption probability in the active gas volume. This geometry provides also efficient and fast signal creation, as well as read-out, of the order of 200 μs per charged particle track. The performance of this detector is maximized by reducing the material budget between the radiator and gas volume to a minimum. The full detector at SIS100 will be composed of 200 modules in 2 sizes. To limit cost and production time the number of various module types is limited to 6 types and 4 types of Front End Board (FEB) flavors are required. An overview of the design and performance of the TRD detector is given.

  1. Genetics of human sensitivity to ultraviolet radiation

    Science.gov (United States)

    Cleaver, James E.

    1994-07-01

    the major human health effects of solar and artificial UV light occur from the UVB and UVC wavelength ranges and involve a variety of short-term and long-term deleterious changes to the skin and eyes. the more important initial damage to cellular macromolecules involves dimerization of adjacent pyrimidines in DNA to produce cyclobutane pyrimidine dimes, (6-4) pyrimidine- pyrimidone, and (6-4) dewar photoproducts. these photoproducts can be repaired by a genetically regulated enzyme system (nucleotide excision repair) which removes oligonucleotides 29-30 nucleotides long that contain the photoproducts, and synthesizes replacement patches. At least a dozen gene products are involved in the process of recognizing photoproducts in DNA, altering local DNA helicity and cleaving the polynucleotide chain at defined positions either side of a photoproduct. Hereditary mutations in many of these genes are recognized in the human genetic disorders xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). Several of the gene products have other functions involving the regulation of gene transcription which accounts for the complex clinical presentation of repair deficient diseases that involve sensitivity of the skin and eyes to UV light, increased solar carcinogenesis (in XP), demyelination, and ganglial calcification (in CS), hair abnormalities (in TTD), and developmental and neurological abnormalities

  2. Radiation sensitivity of human lung cancer cell lines

    International Nuclear Information System (INIS)

    Carmichael, J.; Degraff, W.G.; Gamson, J.; Russo, G.; Mitchell, J.B.; Gazdar, A.F.; Minna, J.D.; Levitt, M.L.

    1989-01-01

    X-Ray survival curves were determined using a panel of 17 human lung cancer cell lines, with emphasis on non-small cell lung cancer (NSCLC). In contrast to classic small cell lung cancer (SCLC) cell lines, NSCLC cell lines were generally less sensitive to radiation as evidenced by higher radiation survival curve extrapolation numbers, surviving fraction values following a 2Gy dose (SF2) and the mean inactivation dose values (D) values. The spectrum of in vitro radiation responses observed was similar to that expected in clinical practice, although mesothelioma was unexpectedly sensitive in vitro. Differences in radiosensitivity were best distinguished by comparison of SF2 values. Some NSCLC lines were relatively sensitive, and in view of this demonstrable variability in radiation sensitivity, the SF2 value may be useful for in vitro predictive assay testing of clinical specimens. (author)

  3. The causes and consequences of human exposure to ionising radiation

    International Nuclear Information System (INIS)

    Clarke, R.H.

    1991-01-01

    Few phenomena cause as much concern in developed countries as human exposure to artificial sources of radiation, and yet there are more potent threats to health: natural radiation is more pervasive and exposures more substantial; common practices such as smoking and drinking are more detrimental. Developing countries may be more anxious to establish radiological procedures than radiological protection. This paper gives the ranges of exposure to which people are subjected from natural and artificial sources which should help to put all doses in perspective. The relationship between dose and risk is established and used to show that exposures to radiation leak to low levels of risk. Finally, the new recommendations of ICRP for the control of radiation risk are presented. (Author)

  4. Advances in radiation biology: Relative radiation sensitivities of human organ systems. Volume 12

    International Nuclear Information System (INIS)

    Lett, J.T.; Altman, K.I.; Ehmann, U.K.; Cox, A.B.

    1987-01-01

    This volume is a thematically focused issue of Advances in Radiation Biology. The topic surveyed is relative radiosensitivity of human organ systems. Topics considered include relative radiosensitivities of the thymus, spleen, and lymphohemopoietic systems; relative radiosensitivities of the small and large intestine; relative rediosensitivities of the oral cavity, larynx, pharynx, and esophagus; relative radiation sensitivity of the integumentary system; dose response of the epidermal; microvascular, and dermal populations; relative radiosensitivity of the human lung; relative radiosensitivity of fetal tissues; and tolerance of the central and peripheral nervous system to therapeutic irradiation

  5. Advances in radiation biology: Relative radiation sensitivities of human organ systems. Volume 12

    Energy Technology Data Exchange (ETDEWEB)

    Lett, J.T.; Altman, K.I.; Ehmann, U.K.; Cox, A.B.

    1987-01-01

    This volume is a thematically focused issue of Advances in Radiation Biology. The topic surveyed is relative radiosensitivity of human organ systems. Topics considered include relative radiosensitivities of the thymus, spleen, and lymphohemopoietic systems; relative radiosensitivities of the small and large intestine; relative rediosensitivities of the oral cavity, larynx, pharynx, and esophagus; relative radiation sensitivity of the integumentary system; dose response of the epidermal; microvascular, and dermal populations; relative radiosensitivity of the human lung; relative radiosensitivity of fetal tissues; and tolerance of the central and peripheral nervous system to therapeutic irradiation.

  6. Ionizing radiation and lipid peroxidation in human body

    International Nuclear Information System (INIS)

    Giubileo, Gianfranco

    1997-07-01

    Lipids are organic compounds constituting the living cells. Lipid molecules can be disassembled through peroxidative pathways and hydrocarbons can be bred as end-product of lipid peroxidation in vivo. Lipid peroxidation can be started by an indirect effect of ionizing radiation. So a radioinduced cellular damage in human body can be detected by monitoring the production of specific hydrocarbons

  7. Biological effects of radiation human health and safety

    International Nuclear Information System (INIS)

    1977-05-01

    The biological hazards of nuclear energy usage are a growing source of public concern. The medical profession may well be expected to contribute to public debate on the issue. This document, therefore, attempts a balanced review of the known and suspected human biological consequences of exposure to different types of ionizing radiation, emphasizing in particular the nuclear industry

  8. Effects of ultraviolet radiation on the immune system in humans

    International Nuclear Information System (INIS)

    Morison, W.L.

    1989-01-01

    In experimental animals, exposure to UV-B radiation produces selective alterations of immune function which are mainly in the form of suppression of normal immune responses. This immune suppression is important in the development of nonmelanoma skin cancer, may influence the development and course of infectious disease and possibly protects against autoimmune reactions. The evidence that this form of immune suppression occurs in humans is less compelling and very incomplete. The wavelengths of radiation most affected by a depletion of the stratospheric ozone layer are those known to be most immunosuppressive in animals and it is likely that such depletion will increase any suppressive effect of sunlight on immunity in humans. In addition to establishing whether or not UV-B radiation can cause suppression of immune function in humans, studies are required to determine if melanin can provide protection against such suppression, the role of this suppression in the pathogenesis of skin cancer, the development of infectious disease and vaccine effectiveness, and the capacity for humans to develop adaptive, protective mechanisms which may limit damage from continued exposure to UV-B radiation. (author)

  9. Reducing Human Radiation Risks on Deep Space Missions

    Science.gov (United States)

    2017-09-01

    101 Figure 49. Human Health, Life Support, and Habitation System...2013). These same studies reveal that for astronauts returning home, this may result in significant loss of lifespan and quality of life due to...warnings to the satellites in orbit at either planet , or to spacecraft in transit (Phys.org 2010). C. IMPROVEMENTS TO MEASUREMENTS OF SPACE RADIATION

  10. NOAA-9 Earth Radiation Budget Experiment (ERBE) scanner offsets determination

    Science.gov (United States)

    Avis, Lee M.; Paden, Jack; Lee, Robert B., III; Pandey, Dhirendra K.; Stassi, Joseph C.; Wilson, Robert S.; Tolson, Carol J.; Bolden, William C.

    1994-01-01

    The Earth Radiation Budget Experiment (ERBE) instruments are designed to measure the components of the radiative exchange between the Sun, Earth and space. ERBE is comprised of three spacecraft, each carrying a nearly identical set of radiometers: a three-channel narrow-field-of-view scanner, a two-channel wide-field-of-view (limb-to-limb) non-scanning radiometer, a two-channel medium field-of view (1000 km) non-scanning radiometer, and a solar monitor. Ground testing showed the scanners to be susceptible to self-generated and externally generated electromagnetic noise. This paper describes the pre-launch corrective measures taken and the post-launch corrections to the NOAA-9 scanner data. The NOAA-9 scanner has met the mission objectives in accuracy and precision, in part because of the pre-launch reductions of and post-launch data corrections for the electromagnetic noise.

  11. Radiation load experiments with electronic components of the SYMPHONIE satellite

    International Nuclear Information System (INIS)

    Spencker, A.; Wagemann, H.G.; Braeunig, D.

    1975-09-01

    This report surveys fundamentals, realization and results of irradiation experiments which applied to 36 different electronic components of the Symphonie satellite and which were completed at the HMI Berlin and the C.N.E.T. Lannion in the years 1972/73. In a general section the evaluation of equivalent fluencies concerning 1 MeV electrons as radiation simulating the extraterrestric particle spectra with regard to the well-known semiconductor damage mechanisms is discussed. Then the realization of irradiation testing for the Symphonie satellite is described. Three selected examples demonstrate typical failure modes of semiconductor devices under radiation stress: Finally the main experimental results are shown in a standardized manner; a survey in English is given on p. 44. (orig.) [de

  12. Radiation processing for cultural heritage preservation – Romanian experience

    Directory of Open Access Journals (Sweden)

    Moise Ioan Valentin

    2017-12-01

    Full Text Available Radiation sterilization has been considered a mass decontamination technique for biodegradable cultural heritage (CH since its widespread application in the medical field. Initial experiments have revealed advantages, for example, efficiency and effectiveness, but also disadvantages, namely “side effects” concerning CH materials. More than 50 years later, the adequacy of ionizing radiation for some CH artefacts is still the subject of discussion. The main reason why is that science and industry are not yet able to provide a more efficient technique for treating mass decontamination. For wooden items, there is general agreement that the irradiation dose required for insect eradication is not damaging, even in the case of polychromed wood. For cellulose pulp (paper, there is a reduction in polymerization degree (DP at the high doses necessary to stop the attack of fungi, but this should be considered taking into account the purpose of the treatment. Emergency or rescue treatments are necessary to mitigate the consequences of accidents or improper storage conditions. In some cases (archives, the value of written information is greater than the historical value of the paper support. For other materials, namely textiles, leather and parchment, less research has been published on the effect of ionizing radiation treatment. As a general rule, irradiation is not necessary when only a few CH elements are present that are affected by biological contamination since restorers can solve the problem by classical means. The need for radiation treatment arises when large collections (hundreds, thousands or even more elements are heavily affected by the biological attack. In Romania, the IRASM gamma irradiator of IFIN-HH is receiving an increasing number of requests for CH treatment, mainly due to an intensive research programme concerning this topic and close liaison with CH owners or administrators. Besides reviewing the scientific results obtained in

  13. Experience of the international network in radiation protection

    International Nuclear Information System (INIS)

    Medina Gironzini, Eduardo

    2008-01-01

    With the aim of exchanging information on various subjects about radiation protection and designing a site where the members can send and receive information on courses, scientific activities, articles, technical opinions, commentaries and everything that promotes the communication, collaboration and integration, the 15th March 2002 the networking: 'radioproteccion' is created with 11 persons from 11 countries. The number of members had been increased. By the first month it had 117 members and by the end of the year 2002 it had already 179 members, 315 messages were send by then. By December 2007, there were 726 members from 28 countries mainly from Latin America: Argentina, Brazil, Bolivia, Chile, Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Uruguay and Venezuela. There were also members from Austria, Canada, France, Israel, Italy, Portugal, Spain, Sweden, United Kingdom and United States. There have been distributed 2049 messages about Congress, courses and activities on national and international radiation protection and related issues which initially were in Latin American and the Caribbean. This has allowed diverse specialists that work in different themes to interchange experiences and information about subjects of common interest. This objective is the continuation of the spreading of activities that since 1991 and for 10 consecutive years had been made through the Bulletin 'Proteccion Radiologica', from which 65000 samples were published and distributed to specialists from 40 countries thanks to the support of the International Atomic Energy Agency (IAEA) and the Pan-American Health Organization (PAHO). This idea is complemented by the Web: www.radioproteccion.org. Interesting topics have been discussed in the network for example: Pregnancy and medical radiation, emergency response, occupational exposure, radiation protection responsibilities, lessons learned from accidental

  14. 21 century perspective in radiation protection of humans and human population

    International Nuclear Information System (INIS)

    Vassilev, G.

    2003-01-01

    In 21 century ionizing radiation is applied in all field of human activities. In parallel, the radiobiology and radiation medicine are developing as separate branches for the purposes of the radiation protection: for risk estimation and regulation of the human irradiation. Main features of radiation protection at the beginning of the century are: 1.Well developed conservative theoretical background, based on the linear non-threshold concept 'dose-effect' towards the carcinogenesis and genetic effects; 2. Developed international and national structures, including organizations as ICRP, UNSCEAR, ICRU, IAEA, WHO, FAO, BEIR, OECD/NEA, ILO, NCRP, NRPB etc. 3. Detailed regulative legislation for all cases of human irradiation, combines with effective control structures. Ionizing radiation is the most strictly regulated factor affecting humans among the all adverse impacts of the living environment. The expectations for the radiation protection in 21 century are: 1. A radical reassessment of the concept for low doses and the linear non-threshold concept since data for existing of a threshold on the human population level. 2. Taking into consideration of the the adaptation to the irradiation, comparable with the natural radiation background. 3. Taking into consideration of the radiation hormesis, which are now ignored by the risk theory. 4. Clarification of the questions of the genetic effects, which are not yet determined for the human population. 5. Radical solutions of the radioactive waste problem, which will be crucial for the future of the nuclear energy production. 6. Gradual overcoming of the fear from ionizing radiation, which is an important social factor

  15. Management of Spent and Disused Radiation Sources - The Zambian Experience

    International Nuclear Information System (INIS)

    Chabala, F.

    2002-01-01

    Zambia like all other countries in the world is faced with environmental problems brought about by a variety of human activities. In Zambia the major environmental issues as identified by Nation Environmental Action Plan (NEAP) of 1994 are water pollution, poor sanitation, land degradation, air pollution, poor waste management, misuse of chemicals, wildlife depletion and deforestation. Zambian has been using a lot of radioactive materials in its various industries. The country has taken several projects with help of external partners. These partners however left these projects in the hands of the Zambians without developing their capacities to manage these radioactive sources. The Government recognized the need to manage these sources and passed legislation governing the management of radioactive materials. The first act of Parliament on Radiation Protection work was passed in 1975 to legislate the use of ionizing radiation. However, because of financial constraints the Country is facing, these regulations have remained unimplemented. Fortunately the international Community has been working in partnership with the Zambian Government in the Management of Radioactive Material. Therefore this paper will present the following aspects of radioactive waste management in Zambia: review Existing Legislation in Zambia regarding management of spent/radioactive sources; capacity building in the field of management of radioactive waste; management of spent and disused radiation sources; existing disposal systems in Zambia regarding spent/orphaned sources; existing stocks of radioactive sources in the Zambian industries

  16. A New Transition Radiation Detector for the CREAM experiment

    CERN Document Server

    Malinin, A; Angelaszek, D

    The Cosmic Ray Energetics And Mass (CREAM) experiment is designed to investigate the source, propagation and acceleration mechanism of high energy cosmic-ray nuclei, by directly measuring their energy and charge. Incorporating a Transition Radiation Detector (TRD) provides a model independent energy measurement complementary to the calorimeter, as well as additional track reconstruction capability. A new TRD design provides a compact, robust, reliable, low density detector to measure incident nucleus energy for 3 < Z < 26 nuclei in the Lorentz gamma factor range of 10 2 -10 5. The TRD design, R&D;, construction milestones, beam test results and a progress of the final TRD integration in the CREAM instrument are reported.

  17. Radiation-Induced Differentiation in Human Lung Fibroblast

    International Nuclear Information System (INIS)

    Park, Sa-Rah; Ahn, Ji-Yeon; Han, Young-Soo; Shim, Jie-Young; Yun, Yeon-Sook; Song, Jie-Young

    2007-01-01

    One of the most common tumors in many countries is lung cancer and patients with lung cancer may take radiotherapy. Although radiotherapy may have its own advantages, it can also induce serious problems such as acute radiation pneumonitis and pulmonary fibrosis. Pulmonary fibrosis is characterized by excessive production of α-SMA and accumulation of extracellular matrix (ECM) such as collagen and fibronectin. There has been a great amount of research about fibrosis but the exact mechanism causing the reaction is not elucidated especially in radiation-induced fibrosis. Until now it has been known that several factors such as transforming growth factor (TGF-β), tumor necrosis factor (TNF), interleukin (IL)-1, IL-6, platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) are related to fibrosis. Among them TGF-β with Smad signaling is known to be the main stream and other signaling molecules such as MAPK, ERK and JNK (3) also participates in the process. In addition to those above factors, it is thought that more diverse and complicate mechanisms may involve in the radiationinduced fibrosis. Therefore, to investigate the underlying mechanisms in radiation induced fibrosis, first of all, we confirmed whether radiation induces trans differentiation in human normal lung fibroblasts. Here, we suggest that not only TGF-β but also radiation can induce trans differentiation in human lung fibroblast WI-38 and IMR-90

  18. JET Radiative Mantle Experiments in ELMy H-Mode

    International Nuclear Information System (INIS)

    Budny, R.; Coffey, I.; Dumortier, P.; Grisolia, C.; Strachan, J.D.

    1999-01-01

    Radiative mantle experiments were performed on JET ELMy H-mode plasmas. The Septum configuration was used where the X-point is embedded into the top of the Septum. Argon radiated 50% of the input power from the bulk plasma while Z eff rose from an intrinsic level of 1.5 to about 1.7 due to the injected Argon. The total energy content and global energy confinement time decreased 15% when the impurities were introduced. In contrast, the effective thermal diffusivity in the core confinement region (r/a = .4--.8) decreased by 30%. Usually, JET ELMy H-mode plasmas have confinement that is correlated to the edge pedestal pressure. The radiation lowered the edge pedestal and consequently lowered the global confinement. Thus the confinement was changed by a competition between the edge pedestal reduction lowering the confinement and the weaker RI effect upon the core transport coefficients raising the confinement. The ELM frequency increased from 10 Hz Type I ELMs, to 200 Hz type III ELMs. The energy lost by each ELM reduced to 0.5% of the plasma energy content

  19. Field experience in use of radiation instruments in Cirus reactor

    International Nuclear Information System (INIS)

    Ramesh, N.; Sharma, R.C.; Agarwal, S.K.; Sawant, D.K.; Yadav, R.K.B.; Prasad, S.K.

    2005-01-01

    Cirus, located at Bhabha Atomic Research Centre, is a 40 MW (Th) research reactor fuelled by natural uranium, moderated by heavy water and cooled by de-mineralized light water. Graphite is used as reflector in this reactor. The reactor, commissioned in the year 1960, was in operation with availability factor of about 70% till early nineties. There after signs of ageing started surfacing up. After ageing studies, refurbishment plan was finalized and executed during the period from 1997-2002. after successful refurbishment, the reactor is in operation at full power. A wide range of radiation instruments have been used at Cirus for online monitoring of the radiological status of various process systems and environmental releases. Also, variety of survey meters, counting systems and monitors have been used by the health physics unit of the reactor for radiation hazard control. Many of these instruments, which were originally of Canadian design, have undergone changes due to obsolescence or as part of upgradation. This paper describes the experience with the radiation instruments of Cirus, bringing out their effectiveness in meeting the design intent, difficulties faced in their field use, and modifications carried out based on the performance feed back. Also, this paper highlights the areas where further efforts are needed to develop nuclear instrumentation to further strengthen monitoring and surveillance. (author)

  20. Romanian Radiation Protection Training Experience in Medical Field

    International Nuclear Information System (INIS)

    Steliana Popescu, F.; Milu, C.; Naghi, E.; Calugareanu, L.; Stroe, F. M.

    2003-01-01

    Studies conducted by the Institute of Public Health Bucharest during the last years emphasised the need of appropriate radioprotection training in the medical field. With the assistance of the International Atomic Energy Agency in Vienna, the Pilot Centre on Clinical Radio pathology in the Institute of Public Health-Bucharest, provided, from 2000 a 7 modular courses (40 hours each), covering the basic topics of ionizing radiation, biological and physical dosimetry, effects of exposure to ionising radiation, radioprotection concepts, planning and medical response in case of a nuclear accident or radiological emergency. The courses are opened for all health specialists, especially for occupational health physicians, focusing on health surveillance of radiation workers and medical management of overexposed workers. Each module is followed up by an examination and credits. The multidisciplinary team of instructors was trained within several train-the-trainers courses, organised by IAEA. The paper discusses the evaluation of these 3 years experience in training and its feedback impact, the aim of the program being to develop a knowledge in the spirit of the new patterns of radiological protection, both for safety and communication with the public. (Author)

  1. In vivo study of human skin using pulsed terahertz radiation

    International Nuclear Information System (INIS)

    Pickwell, E; Cole, B E; Fitzgerald, A J; Pepper, M; Wallace, V P

    2004-01-01

    Studies in terahertz (THz) imaging have revealed a significant difference between skin cancer (basal cell carcinoma) and healthy tissue. Since water has strong absorptions at THz frequencies and tumours tend to have different water content from normal tissue, a likely contrast mechanism is variation in water content. Thus, we have previously devised a finite difference time-domain (FDTD) model which is able to closely simulate the interaction of THz radiation with water. In this work we investigate the interaction of THz radiation with normal human skin on the forearm and palm of the hand in vivo. We conduct the first ever systematic in vivo study of the response of THz radiation to normal skin. We take in vivo reflection measurements of normal skin on the forearm and palm of the hand of 20 volunteers. We compare individual examples of THz responses with the mean response for the areas of skin under investigation. Using the in vivo data, we demonstrate that the FDTD model can be applied to biological tissue. In particular, we successfully simulate the interaction of THz radiation with the volar forearm. Understanding the interaction of THz radiation with normal skin will form a step towards developing improved imaging algorithms for diagnostic detection of skin cancer and other tissue disorders using THz radiation

  2. In vivo study of human skin using pulsed terahertz radiation

    Energy Technology Data Exchange (ETDEWEB)

    Pickwell, E [Semiconductor Physics Group, Cavendish Laboratory, Cambridge University, Madingley Road, Cambridge CB3 0HE (United Kingdom); Cole, B E [TeraView Ltd, Unit 302/4 Cambridge Science Park, Cambridge CB4 0WG (United Kingdom); Fitzgerald, A J [TeraView Ltd, Unit 302/4 Cambridge Science Park, Cambridge CB4 0WG (United Kingdom); Pepper, M [Semiconductor Physics Group, Cavendish Laboratory, Cambridge University, Madingley Road, Cambridge CB3 0HE (United Kingdom); Wallace, V P [TeraView Ltd, Unit 302/4 Cambridge Science Park, Cambridge CB4 0WG (United Kingdom)

    2004-05-07

    Studies in terahertz (THz) imaging have revealed a significant difference between skin cancer (basal cell carcinoma) and healthy tissue. Since water has strong absorptions at THz frequencies and tumours tend to have different water content from normal tissue, a likely contrast mechanism is variation in water content. Thus, we have previously devised a finite difference time-domain (FDTD) model which is able to closely simulate the interaction of THz radiation with water. In this work we investigate the interaction of THz radiation with normal human skin on the forearm and palm of the hand in vivo. We conduct the first ever systematic in vivo study of the response of THz radiation to normal skin. We take in vivo reflection measurements of normal skin on the forearm and palm of the hand of 20 volunteers. We compare individual examples of THz responses with the mean response for the areas of skin under investigation. Using the in vivo data, we demonstrate that the FDTD model can be applied to biological tissue. In particular, we successfully simulate the interaction of THz radiation with the volar forearm. Understanding the interaction of THz radiation with normal skin will form a step towards developing improved imaging algorithms for diagnostic detection of skin cancer and other tissue disorders using THz radiation.

  3. Synchrotron radiation XRF microprobe study of human bone tumor slice

    International Nuclear Information System (INIS)

    Huang Yuying; Zhao Limin; Wang Zhouguang; Shao Hanru; Li Guangcheng; Wu Yingrong; He Wei; Lu Jianxin; He Rongguo

    1999-01-01

    The experimental apparatus of X-ray fluorescence (XRF) microprobe analysis at Beijing Synchrotron Radiation Facility (BSRF) is described. Using the bovine liver as the standard reference, the minimum detection limit (MDL) of trace element was measured to determine the capability of biological sample analysis by synchrotron radiation XRF microprobe. The relative change of the content of the major or trace element in the normal and tumor part of human bone tissue slice was investigated. The experimental result relation to the clinical medicine was also discussed. (author)

  4. Non-carcinogenic late effects of ionizing radiation; human data

    International Nuclear Information System (INIS)

    Beebe, G.W.

    1979-01-01

    The late effects of ionizing radiation may be somatic effect or potential effect, about which such informations as follows are required: teratogenesis the disturbances in growth and development, cataracts, infertility, cytogenetic aberration, and accelerated aging. Although much is known about the nature of the malformations produced by ionizing radiation, and about the vulnerability of human embryonal and fetal tissues during various stages of organogenesis, the quantitative information is uncertain and incomplete. The data on A-bomb survivors were flawed by confounding radiation dose with nutritional and other influences caused by the disasters created by war-time bombings. If the effects of radiation are real, they are quite small for the dose below 100 rad (kerma), are confined to the children of pre-pubertal age at the time of exposure, and are of much less consequence for low-LET radiation than for high. Radiation-induced lenticular changes are of graded severity, and as for cataracts, the threshold is in the range from 600 to 1,000 rad of low-LET radiation, and perhaps 75 to 100 rad for fast neutrons; the average latent period is 2 to 7 years. The estimate of the RBE for neutrons is in the range from 2 to 10, and dose-dependent. Ionizing radiation has important effects on fertility only at very high dose. The relationship of the quantitative aspects of the biologic significance of chromosomal aberration in somatic cells to dose may provide an interesting parallel to the carcinogenic effect. For neutrons, the dose-response curve appears to be linear, at least for stable aberration. (Yamashita, S.)

  5. Relevance of animal studies to the human experience

    International Nuclear Information System (INIS)

    Fry, R.J.M.

    1984-01-01

    Animal experiments are being used to examine a number of physical and biological factors that influence risk estimations, though not usually in coordination with epidemiologists. It is clear that the different mechanisms involved in different types of tumors are reflected in the diversity of dose-response relationships. The forms of the dose-response relationships are influenced by both the initial events and their expression. Evidence is accumulating that many initiated cells do not get expressed as overt cancers and that host factors may play a major role in the expression of potential tumor cells. There is a need for information about the relationship of the natural incidence and susceptibility to radiation induction for more tumor types. Such experiments will help answer the question of which risk estimate models are appropriate for different tumor types, and they can be carried out on animals. Perhaps because of the importance of host factors, risk estimates as a percentage of the natural incidence appear to be similar for human beings and mice for a small number of tumor types. Animal experiments must remain a major approach to the investigation of mechanisms of carcinogenesis. 22 references, 5 figures, 2 tables

  6. Relevance of experimental animal studies to the human experience

    International Nuclear Information System (INIS)

    Fry, R.J.M.

    1982-01-01

    Animal experiments are being used to examine a number of physical and biological factors that influence risk estimations though not usually in coordination with epidemiologists. It is clear that the different mechanisms involved in different types of tumors are reflected in the diversity of dose-response relationships. The forms of the dose-response relationships are influenced by both the initial events and their expression. Evidence is accumulating that many initiated cells do not get expressed as overt cancers and host factors may play a major role in the expression of potential tumor cells. There is a need for information about the relationship of the natural incidence and susceptibility to radiation induction for more tumor types. Such experiments will help answer the question of which risk estimate models are appropriate for different tumor types and can be carried out on animals. Perhaps because of the importance of host factors risk estimates as a percentage of the natural incidence appear to be similar for human beings and mice for a small number of tumor types. The elucidation of the mechanisms involved in different tissues while a slow business remains an important role of animal experiments

  7. Some human activities to decrease public radiation dose

    International Nuclear Information System (INIS)

    Pan Ziqiang; Guo Minqiang

    1994-01-01

    The necessity of studying the variations in radiation levels from the balance viewpoint is discussed. Some human activities may increase, while others may decrease, radiation dose to population. In 1988, China's investigation showed that travel by air caused a raise of population collective dose by 3.6 x 10 1 man·Sv, while travel by ship, train and vehicle lead to a drop of 5.36 x 10 2 man·Sv, and that dwellings of coal cinder brick decreased collective dose by 3.5 x 10 3 man·Sv, while buildings of reinforced concrete structure increased collective dose by 3.7 x 10 3 man·Sv. It is inadequate to only study those activities which may increase radiation levels

  8. Chronic effects of ionizing radiation on animals and humans

    Directory of Open Access Journals (Sweden)

    I. P. Drozd

    2013-03-01

    Full Text Available Numerous experimental radiobiological studies and medical observations were conducted after the Chernobyl disaster based on the published results; patterns and characteristics influence of the fission products of nuclear materials on the body of mammals, including humans were analyzed. Chronic exposure to low doses leads to the changes in the hemopoietic system was founded and increases the risk of myeloproliferative diseases. The con-sequence of radiation-related immunodeficiency is the autoimmune disease and chronic fatigue syndrome. Radi-ation damage leads to endocrine system disruption of the body and of polipatologycal states. High radiosensitivi-ty of the central nervous system was founded. Genotoxic chronic radiation exposure threatens the stability of the genome.

  9. Differential Gene Expression in Primary Human Skin Keratinocytes and Fibroblasts in Response to Ionizing Radiation

    Science.gov (United States)

    Warters, Raymond L.; Packard, Ann T.; Kramer, Gwen F.; Gaffney, David K.; Moos, Philip J.

    2009-01-01

    Although skin is usually exposed during human exposures to ionizing radiation, there have been no thorough examinations of the transcriptional response of skin fibroblasts and keratinocytes to radiation. The transcriptional response of quiescent primary fibroblasts and keratinocytes exposed to from 10 cGy to 5 Gy and collected 4 h after treatment was examined. RNA was isolated and examined by microarray analysis for changes in the levels of gene expression. Exposure to ionizing radiation altered the expression of 279 genes across both cell types. Changes in RNA expression could be arranged into three main categories: (1) changes in keratinocytes but not in fibroblasts, (2) changes in fibroblasts but not in keratinocytes, and (3) changes in both. All of these changes were primarily of p53 target genes. Similar radiation-induced changes were induced in immortalized fibroblasts or keratinocytes. In separate experiments, protein was collected and analyzed by Western blotting for expression of proteins observed in microarray experiments to be overexpressed at the mRNA level. Both Q-PCR and Western blot analysis experiments validated these transcription changes. Our results are consistent with changes in the expression of p53 target genes as indicating the magnitude of cell responses to ionizing radiation. PMID:19580510

  10. A factorial experiment on image quality and radiation dose

    International Nuclear Information System (INIS)

    Norrman, E.; Persliden, J.

    2005-01-01

    To find if factorial experiments can be used in the optimisation of diagnostic imaging, a factorial experiment was performed to investigate some of the factors that influence image quality, kerma area product (KAP) and effective dose (E). In a factorial experiment the factors are varied together instead of one at a time, making it possible to discover interactions between the factors as well as major effects. The factors studied were tube potential, tube loading, focus size and filtration. Each factor was set to two levels (low and high). The influence of the factors on the response variables (image quality, KAP and E) was studied using a direct digital detector. The major effects of each factor on the response variables were estimated as well as the interaction effects between factors. The image quality, KAP and E were mainly influenced by tube loading, tube potential and filtration. There were some active interactions, for example, between tube potential and filtration and between tube loading and filtration. The study shows that factorial experiments can be used to predict the influence of various parameters on image quality and radiation dose. (authors)

  11. The effect of radiation sterilization on human transplantable bone

    International Nuclear Information System (INIS)

    Triantafyllou, N.; Karatzas, P.

    1974-11-01

    In order to study the effect of radiation sterilization on human transplantable bones, work was carried out on human and bovine bone tissue samples. Factors causing possible alterations in the mechanical structures of the preserved bone allografts were considered to be deep freezing (-35degC), lyophylization, irradiation, or a combination of lyophylization and irradiation. The latter could be shown to lower the mechanical strength of the bone. Crystal lattice of the bone did not show any alterations in x-ray diffraction pattern, following freeze drying and/or irradiation with doses up to 10 Mrad of gamma radiation. Deterioration in mechanical properties is probably due to damage to the organic phase of the bone matrix

  12. Study of ionizing radiation effect on human spermatozoa chromosomes

    International Nuclear Information System (INIS)

    Rousseaux, S.

    1990-02-01

    The purpose of this thesis is to study the radio-induced chromosomal aberrations in spermatozoa. After a brief recall on ionizing radiations, the author reviews the radio-induced chromosomal anomalies on somatic cells and on germinal line cells and spermatozoa. The author presents the technical aspects of human spermatozoa karyotype and finally studies the radio induced chromosomal anomalies of sperm to patients undergoing a radiotherapy. 13 tabs., 28 figs., 28 photos

  13. The comparative radiation genetics of humans and mice

    International Nuclear Information System (INIS)

    Neel, J.V.

    1990-01-01

    The attempt by geneticists to predict the genetic consequences for humans of exposure to ionizing radiation has arguably been one of the most serious social responsibilities they have faced in the past half century. Important for its own sake, this issue also serves as a prototype for the effort to evaluate the ultimate genetic impact on ourselves of other human perturbations of the environment in which our species functions. Recently the authors have been developing the thesis that according to the results of studies on the children of survivors of the atomic bombings, humans may not be as sensitive to the genetic effects of radiation as has been projected by various committees on the basis of data from the most commonly employed paradigm, the laboratory mouse. In this paper, the authors attempt as detailed a comparison as space permits of the findings on humans and mice, presenting the data in a fashion that will enable those who at certain critical points in the argument wish to make other assumptions, to do so. The authors argue that a reconsideration that includes all the data now available on mice brings the estimate of the doubling dose for mice into satisfactory agreement with the higher estimate based on humans

  14. Biological effects of alpha radiation on a human population

    International Nuclear Information System (INIS)

    Thorleifson, E.M.; Marro, L.; Tracy, B.L.; Wilkinson, D.; Segura, T.M.; Prud'homme-Lalonde, L.; Leach, K.; Ford, B.N.

    2003-01-01

    Full text: In the environment, natural and man-made sources of radioactive material can become integrated into the food chain. Polonium-210 is a significant source of radiation exposure to caribou and to northern human populations who are dependent on caribou for a major portion of their meat supply. Previous work has shown that humans consuming caribou meat containing measurable quantities of polonium-210 can incorporate a substantial fraction of the radionuclide (Thomas et. al.). Conventional chromosome aberration analysis of blood samples collected from 40 individuals who routinely consumed caribou meat was performed to measure genetic damage from the ingested radioactive material. At least 500 metaphase spreads were analysed for each of 39 individuals. Radiation-specific chromosomal aberrations such as dicentrics and rings were scored and their frequencies were compared to the range of aberrations observed in non-caribou consuming populations. This study was designed to address the possible impact of environmental polonium-210 on background radiation health effects in humans

  15. Biological wound dressings sterilized with gamma radiation: Mexican clinical experience

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Pardo, M.E. [Instituto Nacional de Investigaciones Nucleares, Apdo. postal 18-1027, Col. Escandon 11801 Mexico DF (Mexico)], E-mail: memp@nuclear.inin.mx; Ley-Chavez, E. [ISSEMYM Toluca, Mexico DF (Mexico); Reyes-Frias, M.L. [Instituto Nacional de Investigaciones Nucleares, Apdo. postal 18-1027, Col. Escandon 11801 Mexico DF (Mexico); Rodriguez-Ferreyra, P. [Hospital ' Dr. Nicolas San Juan' , Toluca, Mexico DF (Mexico); Vazquez-Maya, L.; Salazar, M.A. [Hospital General de Mexico, Mexico DF (Mexico)

    2007-11-15

    Biological wound dressings sterilized with gamma radiation, such as amnion and pig skin, are a reality in Mexico. These tissues are currently processed in the tissue bank and sterilized in the Gamma Industrial Irradiation Plant; both facilities belong to the Instituto Nacional de Investigaciones Nucleares (ININ) (National Institute of Nuclear Research). With the strong support of the International Atomic Energy Agency, the bank was established at the ININ and the Mexican Ministry of Health issued its sanitary license on July 7, 1999. The Quality Management System of the bank was certified by ISO 9001:2000 on August 1, 2003; the scope of the system is 'Research, Development and Processing of Biological Tissues Sterilized with Gamma Radiation'. At present, more than 150 patients from 16 hospitals have been successfully treated with these tissues. This paper presents a brief description of the tissue processing, as well as the present Mexican clinical experience with children and adult patients who underwent medical treatment with radiosterilized amnion and pig skin, used as biological wound dressings on burns and ocular surface disorders.

  16. Biological wound dressings sterilized with gamma radiation: Mexican clinical experience

    Science.gov (United States)

    Martínez-Pardo, M. E.; Ley-Chávez, E.; Reyes-Frías, M. L.; Rodríguez-Ferreyra, P.; Vázquez-Maya, L.; Salazar, M. A.

    2007-11-01

    Biological wound dressings sterilized with gamma radiation, such as amnion and pig skin, are a reality in Mexico. These tissues are currently processed in the tissue bank and sterilized in the Gamma Industrial Irradiation Plant; both facilities belong to the Instituto Nacional de Investigaciones Nucleares (ININ) (National Institute of Nuclear Research). With the strong support of the International Atomic Energy Agency, the bank was established at the ININ and the Mexican Ministry of Health issued its sanitary license on July 7, 1999. The Quality Management System of the bank was certified by ISO 9001:2000 on August 1, 2003; the scope of the system is "Research, Development and Processing of Biological Tissues Sterilized with Gamma Radiation". At present, more than 150 patients from 16 hospitals have been successfully treated with these tissues. This paper presents a brief description of the tissue processing, as well as the present Mexican clinical experience with children and adult patients who underwent medical treatment with radiosterilized amnion and pig skin, used as biological wound dressings on burns and ocular surface disorders.

  17. ARM West Antarctic Radiation Experiment (AWARE) Field Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Lubin, Daniel [Univ. of California, San Diego, CA (United States). Scripps Inst. of Oceanography; Bromwich, David H [Ohio State University; Vogelmann, Andrew M [Brookhaven National Lab. (BNL), Upton, NY (United States); Verlinde, Johannes [Pennsylvania State Univ., University Park, PA (United States); Russell, Lynn M [Univ. of California, San Diego, CA (United States). Scripps Inst. of Oceanography

    2017-09-15

    The U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) West Antarctic Radiation Experiment (AWARE) is the most technologically advanced atmospheric and climate science campaign yet fielded in Antarctica. AWARE was motivated be recent concern about the impact of cryospheric mass loss on global sea level rise. Specifically, the West Antarctic Ice Sheet (WAIS) is now the second largest contributor to rising sea level, after the Greenland Ice Sheet. As steadily warming ocean water erodes the grounding lines of WAIS components where they meet the Amundsen and Bellingshausen Seas, the retreating grounding lines moving inland and downslope on the underlying terrain imply mechanical instability of the entire WAIS. There is evidence that this point of instability may have already been reached, perhaps signifying more rapid loss of WAIS ice mass. At the same time, the mechanical support provided by adjacent ice shelves, and also the fundamental stability of exposed ice cliffs at the ice sheet grounding lines, will be adversely impacted by a warming atmosphere that causes more frequent episodes of surface melting. The surface meltwater damages the ice shelves and ice cliffs through hydrofracturing. With the increasing concern regarding these rapid cryospheric changes, AWARE was motivated by the need to (a) diagnose the surface energy balance in West Antarctica as related to both summer season climatology and potential surface melting, and (b) improve global climate model (GCM) performance over Antarctica, such that future cryospheric projections can be more reliable.

  18. Argentine Radiation Protection Society Experience in RP education and training

    International Nuclear Information System (INIS)

    Bomben, A. M.; Ciallella, N. R.; Thomasz, E.; Rudelli, M.; Gisone, P.; Ventura, M.; Gomez Parada, I.; Signoretta, C.

    2003-01-01

    Since its creation in 1967, the Argentine Radiation Protection Society (SAR) promotes all the radiation protection and nuclear safety aspects not only within the scientific, technical and academic areas, but also to general public. To fulfill this objective, SAR organised training and refresher courses, seminars and workshops on RP subjects. During 2002, SAR organised 7 basic and specialized courses regarding the uses of radioactive materials in industrial applications and the course on medical response in radiological accidents, that was attended by Argentine and other Latin American participants. The programmes of the courses are developed in compliance with the legal requirements and also considering specifics needs. In this paper, the characteristics of the courses are enunciated and basic statistics regarding courses and participants are presented. For the 2003 and 2004, SAR foresees the organisation of 18 courses per year and has the capacity to deliver other courses by request. all the courses are delivered in Spanish language. Based on this educational experience SAR consider a priority the inclusion, of a RP module in all the scientific graduate programmes to generate awareness on the importance of RP. Taking into account the migration of professionals to Europe and North America and the Globalization, SAR advocates the harmonization of RP syllabus to attain an international recognition. (Author)

  19. Biological wound dressings sterilized with gamma radiation: Mexican clinical experience

    International Nuclear Information System (INIS)

    Martinez-Pardo, M.E.; Ley-Chavez, E.; Reyes-Frias, M.L.; Rodriguez-Ferreyra, P.; Vazquez-Maya, L.; Salazar, M.A.

    2007-01-01

    Biological wound dressings sterilized with gamma radiation, such as amnion and pig skin, are a reality in Mexico. These tissues are currently processed in the tissue bank and sterilized in the Gamma Industrial Irradiation Plant; both facilities belong to the Instituto Nacional de Investigaciones Nucleares (ININ) (National Institute of Nuclear Research). With the strong support of the International Atomic Energy Agency, the bank was established at the ININ and the Mexican Ministry of Health issued its sanitary license on July 7, 1999. The Quality Management System of the bank was certified by ISO 9001:2000 on August 1, 2003; the scope of the system is 'Research, Development and Processing of Biological Tissues Sterilized with Gamma Radiation'. At present, more than 150 patients from 16 hospitals have been successfully treated with these tissues. This paper presents a brief description of the tissue processing, as well as the present Mexican clinical experience with children and adult patients who underwent medical treatment with radiosterilized amnion and pig skin, used as biological wound dressings on burns and ocular surface disorders

  20. Supervisor's experiments on radiation safety trainings in school of engineering

    International Nuclear Information System (INIS)

    Nomura, Kiyoshi

    2005-01-01

    Radiation safety training courses in School of Engineering, The University of Tokyo, were introduced. The number of radiation workers and the usage of radiation and radioisotopes have been surveyed for past 14 years. The number of radiation workers in School of Engineering has increased due to the treatment of X-ray analysis of materials, recently. It is important for workers to understand the present situation of School of Engineering before the treatment of radiation and radioisotopes. What the supervisor should tell to radiation workers were presented herewith. The basic questionnaires after the lecture are effective for radiation safety trainings. (author)

  1. Particle and photon detection for a neutron radiative decay experiment

    Energy Technology Data Exchange (ETDEWEB)

    Gentile, T.R. [National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States)], E-mail: thomas.gentile@nist.gov; Dewey, M.S.; Mumm, H.P.; Nico, J.S.; Thompson, A.K. [National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Chupp, T.E. [University of Michigan, Ann Arbor, MI 48109 (United States); Cooper, R.L. [University of Michigan, Ann Arbor, MI 48109 (United States)], E-mail: cooperrl@umich.edu; Fisher, B.M.; Kremsky, I.; Wietfeldt, F.E. [Tulane University, New Orleans, LA 70118 (United States); Kiriluk, K.G.; Beise, E.J. [University of Maryland, College Park, MD 20742 (United States)

    2007-08-21

    We present the particle and photon detection methods employed in a program to observe neutron radiative beta-decay. The experiment is located at the NG-6 beam line at the National Institute of Standards and Technology Center for Neutron Research. Electrons and protons are guided by a 4.6 T magnetic field and detected by a silicon surface barrier detector. Photons with energies between 15 and 750 keV are registered by a detector consisting of a bismuth germanate scintillator coupled to a large area avalanche photodiode. The photon detector operates at a temperature near 80 K in the bore of a superconducting magnet. We discuss CsI as an alternative scintillator, and avalanche photodiodes for direct detection of photons in the 0.1-10 keV range.

  2. Inactivation of human immunodeficiency virus (HIV) by ionizing radiation in body fluids and serological evidence

    International Nuclear Information System (INIS)

    Bigbee, P.D.; Sarin, P.S.; Humphreys, J.C.; Eubanks, W.G.; Sun, D.; Hocken, D.G.; Thornton, A.; Adams, D.E.; Simic, M.G.

    1989-01-01

    A method to use ionizing radiation to inactivate HIV (Human Immunodeficiency Virus) in human body fluids was studied in an effort to reduce the risk of accidental infection to forensic science laboratory workers. Experiments conducted indicate that an X-ray absorbed dose of 25 krad was required to completely inactivate HIV. This does not alter forensically important constituents such as enzymes and proteins in body fluids. This method of inactivation of HIV cannot be used on body fluids which will be subjected to deoxyribonucleic acid (DNA) typing

  3. Radiation hard silicon microstrip detectors for Tevatron experiments

    International Nuclear Information System (INIS)

    Korjenevski, Sergey

    2004-01-01

    The Silicon Microstrip Tracking detectors at the CDF and D0 experiments have now been operating for almost three years at Fermilab. These detectors were designed originally for an integrated luminosity of 2fb -1 . As the expected luminosity for Run IIb at the Tevatron collider was initially envisioned to reach 15fb -1 , radiation tolerances of both devices were revisited, culminating in proposals for new systems. With reduced expectations for total luminosity at ∼6fb -1 , the full detector-replacement projects were terminated. The CDF detector is expected nevertheless to cope efficiently with the lower anticipated dose, however, the D0 experiment is planning a smaller-scale project: a Layer-0 (L0) upgrade of the silicon tracker (D0SMT). The new device will fit between the beam line and the inner layer of the current Tracker. Built of single-sided sensors, this upgrade is expected to perform well in the harsh radiation environment, and be able to withstand an integrated luminosity of 15fb -1 . Prototypes of Run IIb sensors were irradiated using 10MeV protons at the tandem Van de Graaff at the James R. McDonald Laboratory at Kansas State University. A fit to the 10MeV proton data yields a damage parameter αp=11x10-17Acm. This is consistent with results from RD48 (αp=9.9x10-17Acm). The scaling of damage to 1MeV neutron fluence uses a hardness factor (κ) derived from the non-ionizing components of the energy loss (NEIL). NEIL predicts a hardness factor of 3.87 for 10MeV protons. We obtained an experimental value of this factor of 2.54, or 34% smaller than scaling predictions from NEIL

  4. Academic Career Selection and Retention in Radiation Oncology: The Joint Center for Radiation Therapy Experience

    International Nuclear Information System (INIS)

    Balboni, Tracy A.; Chen, M.-H.; Harris, Jay R.; Recht, Abram; Stevenson, Mary Ann; D'Amico, Anthony V.

    2007-01-01

    Purpose: The United States healthcare system has witnessed declining reimbursement and increasing documentation requirements for longer than 10 years. These have decreased the time available to academic faculty for teaching and mentorship. The impact of these changes on the career choices of residents is unknown. The purpose of this report was to determine whether changes have occurred during the past decade in the proportion of radiation oncology trainees from a single institution entering and staying in academic medicine. Methods and Materials: We performed a review of the resident employment experience of Harvard Joint Center for Radiation Therapy residents graduating during 13 recent consecutive years (n = 48 residents). The outcomes analyzed were the initial selection of an academic vs. nonacademic career and career changes during the first 3 years after graduation. Results: Of the 48 residents, 65% pursued an academic career immediately after graduation, and 44% remained in academics at the last follow-up, after a median of 6 years. A later graduation year was associated with a decrease in the proportion of graduates immediately entering academic medicine (odds ratio, 0.78; 95% confidence interval, 0.65-0.94). However, the retention rate at 3 years of those who did immediately enter academics increased with a later graduation year (p = 0.03). Conclusion: During a period marked by notable changes in the academic healthcare environment, the proportion of graduating Harvard Joint Center for Radiation Therapy residents pursuing academic careers has been declining; however, despite this decline, the retention rates in academia have increased

  5. Human performance analysis of industrial radiography radiation exposure events

    International Nuclear Information System (INIS)

    Reece, W.J.; Hill, S.G.

    1995-01-01

    A set of radiation overexposure event reports were reviewed as part of a program to examine human performance in industrial radiography for the US Nuclear Regulatory Commission. Incident records for a seven year period were retrieved from an event database. Ninety-five exposure events were initially categorized and sorted for further analysis. Descriptive models were applied to a subset of severe overexposure events. Modeling included: (1) operational sequence tables to outline the key human actions and interactions with equipment, (2) human reliability event trees, (3) an application of an information processing failures model, and (4) an extrapolated use of the error influences and effects diagram. Results of the modeling analyses provided insights into the industrial radiography task and suggested areas for further action and study to decrease overexposures

  6. Radiation transformation in differentiated human cells in culture

    International Nuclear Information System (INIS)

    Mothersill, C.; Seymour, C.; Moriarty, M.; Malone, J.; Byrne, P.; Hennessy, T.

    1986-01-01

    A tissue culture technique is described for human thyroid tissue as an approach to studying mechanisms of human radiation carcinogenesis. Normal human tissue obtained from surgery is treated in one of two ways, depending upon size of specimen. Large pieces are completely digested in trypsin/ collagenase solution to a single cell suspension. Small pieces of tissue are plated as explants following partial digestion in trypsin/collagenase solution. Following irradiation of the primary differentiated monolayers (normally 10 days after plating), the development of transformed characteristics is monitored in the subsequent subcultures. A very high level of morphological and functional differentiation is apparent in the primary cultures. Over a period of approx. 6 months, the irradiated surviving cells continue to grow in culture, unlike the unirradiated controls which senesce after 2-3 subcultures. (UK)

  7. Assessment of genetic risk for human exposure to radiation

    International Nuclear Information System (INIS)

    Sevcenko, V.A.; Rubanovic, A.V.

    2002-01-01

    Full text: The methodology of assessing the genetic risk of radiation exposure is based on the concept of 'hitting the target' in development of which N.V. Timofeeff-Ressovsky has played and important role. To predict genetic risk posed by irradiation, the U N Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) has worked out direct and indirect methods of assessment, extrapolation, integral and palpitation criteria of risk analysis that together permit calculating the risk from human exposure on the basis of data obtained for mice. Based on the reports of UNSCEAR for the period from 1958 to 2001 the paper presents a retrospective analysis of the use of direct methods and the doubling dose method for quantitative determination of the genetic risk of human exposure expressed as different hereditary diseases. As early as 1962 UNSCEAR estimated the doubling dose (a dose causing as many mutations as those occurring spontaneously during one generation) at 1 Gy for cases of exposure to ionizing radiations with low LET at a low dose rate and this value was confirmed in the next UNSCEAR reports up to now. For cases of acute irradiation the doubling dose was estimated at 0,3-0,4 Gy for the period under review. The paper considers the evolution of the concepts of human natural hereditary variability which is a basis for assessing the risk of exposure by the doubling dose method. The level of human natural genetic variability per 1 000 000 newborns is estimated at 738 000 hereditary diseases including mendelian, chromosomal and multifactorial ones. The greatest difficulties in assessing the doubling dose value were found to occur in the case of multifactorial diseases the pheno typical expression of which depends on mutational events in polygenic systems and on numerous environmental factors. The introduction in calculations of the potential recoverability correction factor (RPCF) made it possible to assess the genetic risk taking into account this class of

  8. Human radiation studies: Remembering the early years. Oral history of Julie Langham Grilly, February 3, 1995

    International Nuclear Information System (INIS)

    1995-09-01

    Julie Langham Grilly was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE) being the widow of Dr. Wright Langham, an investigator of principal interest of the committee. Her extensive experience with research at LANL was also of interest to the committee. Following a brief biographical sketch, Ms. Grilly relates her early postwar experience and her knowledge of Wright Langham's involvement in animal research at Los Alamos, radiolanthanum tests on monkeys, Eniwetok tissue examinations, research on tritium uptake in humans, plutonium injections, tritium injections, EDTA, and etc. In addition to illuminating her former husband as a researcher and as an individual, she also relates her remembrances of Louis Hempelman, Enrico Fermi, Oppenheimer, Edward Teller, and many others

  9. Human radiation studies: Remembering the early years. Oral history of Julie Langham Grilly, February 3, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    Julie Langham Grilly was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE) being the widow of Dr. Wright Langham, an investigator of principal interest of the committee. Her extensive experience with research at LANL was also of interest to the committee. Following a brief biographical sketch, Ms. Grilly relates her early postwar experience and her knowledge of Wright Langham`s involvement in animal research at Los Alamos, radiolanthanum tests on monkeys, Eniwetok tissue examinations, research on tritium uptake in humans, plutonium injections, tritium injections, EDTA, and etc. In addition to illuminating her former husband as a researcher and as an individual, she also relates her remembrances of Louis Hempelman, Enrico Fermi, Oppenheimer, Edward Teller, and many others.

  10. Relative biological effectiveness if alpha radiation for human lung exposure

    International Nuclear Information System (INIS)

    Yarmoshenko, I.; Kirdin, I.; Zhukovsky, M.

    2006-01-01

    Full text of publication follows: The concept of RBE, which introduced by ICRP and ICRU about 50 years ago to compare biological effects of ionizing radiation of different types, still continues to be the essential element of current and projected radiation protection systems in terms of deriving quantities (quality factor and radiation weighting factor). For example, RBE for the stochastic effects induction has to be considered for appropriate radiation weighting of the absorbed dose while estimating equivalent dose. Simulation of lung cancer radiation risk for the cases of inhalation of radon progeny and incorporation of plutonium in lung in comparison with external reference radiation allows assessment of RBE for alpha-radiation. Specific radiation risk models were developed by results of the direct epidemiological studies and used for such simulation. Simulation included published risk models for nuclear workers of the Mayak facilities in the former Soviet Union exposed to incorporated plutonium (Kreisheimer et al., 2003; Gilbert et al., 2004) and underground miners exposed to radon progenies (BEIR VI, 1999). Additionally lung cancer risk model was developed for a case of population indoor radon exposure. Lung cancer risk related to external exposure is estimated using the risk model develop ed using data of Life Span Study of Japanese atomic bomb survivors. By results of lifetime lung cancer risk simulation using Monte Carlo approach estimated median value of RBE in case of indoor radon exposure is 1.5 (with 90% range 0.4 to 7). In case of the two models developed by BEIR VI for lung cancer risk due to radon exposure in underground miners the median values of RBE are 2.1 and 4.4 (with 90% ranges 0.3 to 17 and 0.7 to 45) respectively.Two different models for lung cancer risk related to plutonium exposure resulted in close estimates of RBE: median value of 12 and 13 (with 90% range 4 to 104 and 4 to 136) respectively. Considerable discrepancy between RBE

  11. Human radiation studies: Remembering the early years: Oral history of pathologist Clarence Lushbaugh, M.D., conducted October 5, 1994

    International Nuclear Information System (INIS)

    1995-04-01

    This report provides a transcript of an interview with Dr. Clarance Lushbaugh by representatives of the DOE Office of Human Radiation Experiments. Dr. Lushbaugh was chosen for this interview because of his research involving experimental use of irradiation with human beings at Los Alamos and at the Oak Ridge Institute of Nuclear Science (ORINS). After a brief biographical sketch Dr. Lushbaugh and his assistant Mrs. Ann Swipe defend their use of total body irradiation using the LETBI (Low Exposure Total Body Irradiation) and the LETBI (Medium Energy Total Body Irradiator). Dr. Lushbaugh also discusses his earlier experiments involving use of nitrogen mustards in chemotherapy application, his early interest in the LD50 for man, his early impressions of low-level spray radiation as introduced by Heubline, anedotal information for his duties a pathologist for Los Alamos, and his developing interest in establishing safer radiation limits for human exposure

  12. Impact assessment on the human exposure to environmental radiation

    International Nuclear Information System (INIS)

    Kim, Y.J.; Lee, K.S.; Kim, J.B.; Chun, K.J.; Kim, S.R.; Chung, K.H.

    1983-01-01

    1. The Terrestrial Ecosystem in the Vicinity of Kori Nuclear Power Plant. In order to evaluate the effects of radiation or radionuclides released from the nuclear power plants on human population, field surveys on the terrestrial ecosystem such as the fauna and flora in the vicinity within 15 km from the Kori nuclear power plant were carried out. 2. Level of radionuclides, Metabolism and Chromosome Aberration. The present study was undertaken with the purpose for evaluating 1) the level of Sr-90 in the Korean vertebra, 2) the metabolism of Sr-90 in the rats, 3) the levels of Sr-90 and Cs-137 in the pine needles (Pinus densiflora), 4) the level of Sr-90 in the frogs (Rana nigromaculata) and 5) the radiation effects by internal Sr-90 on the bone marrow. (Author)

  13. Radiative human body cooling by nanoporous polyethylene textile.

    Science.gov (United States)

    Hsu, Po-Chun; Song, Alex Y; Catrysse, Peter B; Liu, Chong; Peng, Yucan; Xie, Jin; Fan, Shanhui; Cui, Yi

    2016-09-02

    Thermal management through personal heating and cooling is a strategy by which to expand indoor temperature setpoint range for large energy saving. We show that nanoporous polyethylene (nanoPE) is transparent to mid-infrared human body radiation but opaque to visible light because of the pore size distribution (50 to 1000 nanometers). We processed the material to develop a textile that promotes effective radiative cooling while still having sufficient air permeability, water-wicking rate, and mechanical strength for wearability. We developed a device to simulate skin temperature that shows temperatures 2.7° and 2.0°C lower when covered with nanoPE cloth and with processed nanoPE cloth, respectively, than when covered with cotton. Our processed nanoPE is an effective and scalable textile for personal thermal management. Copyright © 2016, American Association for the Advancement of Science.

  14. Biological and medical effects of UV radiation on human health

    International Nuclear Information System (INIS)

    Piazena, H.

    1994-01-01

    Effecsts of UV radiation on human health are discussed. UV radiation is taken up through the skin and eyes. In the case of the eyes, the only known effects are damaging ones (e.g. cataracts). Irradiation of the skin, on the other hand, may either have a prophylactic and therapeutic effect or cause health problems if the exposure is too frequent and/or the dose too high. Positive effects are: Stimulation of the vitamin-D-3 synthesis and the autoimmune system, economisation of blood circulation, higher fitness, and the development of a UV protection system in the skin. Negative effects are: UV erythema, disturbances of the unspecific resistance and the immune system, and photocarcinogenesis. (orig.) [de

  15. Natural and anthropogenic radiation exposure of humans in Germany

    International Nuclear Information System (INIS)

    Koelzer, Winfried

    2016-12-01

    The contribution on natural and anthropogenic radiation exposure in Germany covers the following issues: (1) natural radiation exposure: external radiation exposure - cosmic and terrestric radiation, internal radiation exposure - primordial and cosmogenic radionuclides; radiation exposure due to sola neutrinos and geo-neutrinos. (2) Anthropogenic radiation exposure: radiation exposure in medicine, radioactivity in industrial products, radiation exposure during flights, radiation exposure due to nuclear facilities, radiation exposure due to fossil energy carriers in power generation, radiation exposure due to nuclear explosions, radiation exposure due to nuclear accidents. (3) Occupational radiation exposure in Germany: radiation monitoring with personal dosimeters in medicine and industry, dose surveillance of the aviation personal, working places with increases radiation exposure by natural radiation sources.

  16. Radiation dosimetry in human bone using electron paramagnetic resonance

    International Nuclear Information System (INIS)

    Breen, S.L.

    1995-01-01

    Accurate measurements of dose in bone are required in order to improve the dosimetry of systemic radiotherapy for osseous metastases. Bone is an integrating dosimeter which records the radiation history of the skeleton. During irradiation, electrons become trapped in the crystalline component of bone mineral (hydroxyapatite). The traps are very stable; at room temperature, emptying of the traps occurs with a half-life of many years. The population of trapped unpaired electrons is proportional to the radiation dose administered to the bone and can be measured in excised bone samples using electron paramagnetic resonance (EPR). EPR spectra of synthetic hydroxyapatite, irradiated with Co-60, were obtained at room temperature and at 77 K. At room temperature, the radiation-induced signal, with a g-value of 2.001 ± 0.001 increased linearly with absorbed dose above a lower threshold of 3 Gy, up to doses of 200 Gy. In contrast with pure hydroxyapatite, EPR spectra of excised human bone showed a broad 'native' signal, due to the organic component of bone, which masks the dosimetrically important signal. This native signal is highly variable from sample to sample and precludes the use of EPR as an absolute dosimetry technique. However, after subtraction of the background signal, irradiated human bone showed a linear response with a lower limit of measurement similar to that of synthetic hydroxyapatite. Bone is an in vivo linear dosimeter which can be exploited to develop accurate estimates of the radiation dose delivered during systemic radiotherapy and teletherapy. However, improved sensitivity of the EPR dosimetry technique is necessary before it can be applied reliably in clinical situations. (author)

  17. The new atomic act. Radiation exposure from radon and natural radiation sources in workplaces and the experience of surveillance

    International Nuclear Information System (INIS)

    Sinaglova, R.

    2018-01-01

    In this presentation the new atomic act approved in the Czech republic is analyzed from the point of view of irradiation from radon and natural radiation sources in workplaces. Experience of supervision are also discussed. (authors)

  18. Impact of UV Radiation on Genome Stability and Human Health.

    Science.gov (United States)

    Roy, Sujit

    2017-01-01

    Gradual depletion of the atmospheric ozone layer during the past few years has increased the incidence of solar UV radiation specifically the UV-C on earth's surface is one of the major environmental concerns because of the harmful effects of this radiation in all forms of life. The solar UV radiation including the harmful wavelength range of UV-B (280-320 nm) represents a significant climatic stress for both animals and plants, causing damage to the fundamental biomolecules such as DNA, proteins and lipids, thus activating genotoxic stress and induces genome instability. When DNA absorbs UV-B light, energy from the photon causes covalent linkages to form between adjacent pyrimidine bases, creating photoproducts, primarily cyclobutane pyrimidine dimers (CPDs) and pyrimidine-6,4-pyrimidinone photoproduct (6,4PPs). Pyrimidine dimers create distortions in the DNA strands and therefore can inhibit DNA replication as well transcription. Lack of efficient repair of UV-induced DNA damage may induce the formation of DNA double stand breaks (DSBs), one of the serious forms of damage in DNA double helix, as well as oxidative damage. Unrepaired DSBs in the actively dividing somatic cells severely affect cell growth and development, finally results in loss of cell viability and development of various diseases, such as cancer in man.This chapter mainly highlights the incidence of solar UV-radiation on earth's surface along with the formation of major types of UV-induced DNA damage and the associated repair mechanisms as well as methods of detecting DNA damage and finally our present understanding on the impact on solar UV radiation on human health.

  19. Radiation-induced bystander effects in cultured human stem cells.

    Directory of Open Access Journals (Sweden)

    Mykyta V Sokolov

    2010-12-01

    Full Text Available The radiation-induced "bystander effect" (RIBE was shown to occur in a number of experimental systems both in vitro and in vivo as a result of exposure to ionizing radiation (IR. RIBE manifests itself by intercellular communication from irradiated cells to non-irradiated cells which may cause DNA damage and eventual death in these bystander cells. It is known that human stem cells (hSC are ultimately involved in numerous crucial biological processes such as embryologic development; maintenance of normal homeostasis; aging; and aging-related pathologies such as cancerogenesis and other diseases. However, very little is known about radiation-induced bystander effect in hSC. To mechanistically interrogate RIBE responses and to gain novel insights into RIBE specifically in hSC compartment, both medium transfer and cell co-culture bystander protocols were employed.Human bone-marrow mesenchymal stem cells (hMSC and embryonic stem cells (hESC were irradiated with doses 0.2 Gy, 2 Gy and 10 Gy of X-rays, allowed to recover either for 1 hr or 24 hr. Then conditioned medium was collected and transferred to non-irradiated hSC for time course studies. In addition, irradiated hMSC were labeled with a vital CMRA dye and co-cultured with non-irradiated bystander hMSC. The medium transfer data showed no evidence for RIBE either in hMSC and hESC by the criteria of induction of DNA damage and for apoptotic cell death compared to non-irradiated cells (p>0.05. A lack of robust RIBE was also demonstrated in hMSC co-cultured with irradiated cells (p>0.05.These data indicate that hSC might not be susceptible to damaging effects of RIBE signaling compared to differentiated adult human somatic cells as shown previously. This finding could have profound implications in a field of radiation biology/oncology, in evaluating radiation risk of IR exposures, and for the safety and efficacy of hSC regenerative-based therapies.

  20. Transgenerational effects of radiation and chemicals in mice and humans

    International Nuclear Information System (INIS)

    Nomura, Taisei

    2006-01-01

    Parental exposure of mice to radiation and chemicals causes a variety of adverse effects (e.g., tumors, congenital malformations and embryonic deaths) in the progeny and the tumor-susceptibility phenotype is transmissible beyond the first post-radiation generation. The induced rates of tumors were 100-fold higher than those known for mouse specific locus mutations. There were clear strain differences in the types of naturally-occurring and induced tumors and most of the latter were malignant. Another important finding was that germ-line exposure elicited very weak tumorigenic responses, but caused persistent hypersensitivity in the offspring for the subsequent development of cancer by the postnatal environment. Activations of oncogenes, ras, mos, abl, etc. and mutations in tumor suppressor genes such as p53 were also detected in specific tumors in cancer-prone descendants. However, the majority of tumors observed in the progeny were those commonly observed in the strains that were used and oncogene activations were rarely observed in these tumors. It can be hypothesized that genetic instability modifies tumor occurrence in a transgenerational manner, but so far no links could be established between chromosomal and molecular changes and transmissible tumor risks. Our data are consistent with the hypothesis that cumulative changes in many normal but cancer-related genes affecting immunological, biochemical and physiological functions may slightly elevate the incidence of tumors or fasten the tumor development. This hypothesis is supported by our GeneChip analyses which showed suppression and/or over-expression of many such genes in the offspring of mice exposed to radiation. In humans, a higher risk of leukemia and birth defects has been reported in the children of fathers who had been exposed to radionuclides in the nuclear reprocessing plants and to diagnostic radiation. These findings have not been supported in the children of atomic bomb survivors in Hiroshima

  1. Radiation Environments for Future Human Exploration Throughout the Solar System.

    Science.gov (United States)

    Schwadron, N.; Gorby, M.; Linker, J.; Riley, P.; Torok, T.; Downs, C.; Spence, H. E.; Desai, M. I.; Mikic, Z.; Joyce, C. J.; Kozarev, K. A.; Townsend, L. W.; Wimmer-Schweingruber, R. F.

    2016-12-01

    Acute space radiation hazards pose one of the most serious risks to future human and robotic exploration. The ability to predict when and where large events will occur is necessary in order to mitigate their hazards. The largest events are usually associated with complex sunspot groups (also known as active regions) that harbor strong, stressed magnetic fields. Highly energetic protons accelerated very low in the corona by the passage of coronal mass ejection (CME)-driven compressions or shocks and from flares travel near the speed of light, arriving at Earth minutes after the eruptive event. Whether these particles actually reach Earth, the Moon, Mars (or any other point) depends on their transport in the interplanetary magnetic field and their magnetic connection to the shock. Recent contemporaneous observations during the largest events in almost a decade show the unique longitudinal distributions of this ionizing radiation broadly distributed from sources near the Sun and yet highly isolated during the passage of CME shocks. Over the last decade, we have observed space weather events as the solar wind exhibits extremely low densities and magnetic field strengths, representing states that have never been observed during the space age. The highly abnormal solar activity during cycles 23 and 24 has caused the longest solar minimum in over 80 years and continues into the unusually small solar maximum of cycle 24. As a result of the remarkably weak solar activity, we have also observed the highest fluxes of galactic cosmic rays in the space age and relatively small particle radiation events. We have used observations from LRO/CRaTER to examine the implications of these highly unusual solar conditions for human space exploration throughout the inner solar system. While these conditions are not a show-stopper for long-duration missions (e.g., to the Moon, an asteroid, or Mars), galactic cosmic ray radiation remains a significant and worsening factor that limits

  2. Final report on effects of environmental radiation of Kori nuclear power plant on human population

    International Nuclear Information System (INIS)

    Kim, Y.J.; Kim, J.B.; Chung, K.H.; Lee, K.S.; Kim, S.R.; Yang, S.Y.

    1980-01-01

    In order to clarify and protect the effects of environmental radiation according to the operation of Kori nuclear power plant on the human population, the base line survey for the human monitoring, human life habits, expected individual exposure dose, frequencies of chromosomal aberration, gene frequencies and karyotypes in amphibia, fauna, and radiation sensitivities in microorganisms which have been living around the power plant site were carried out. Kilchonri population which took for the human monitoring lie within a 2 km distance from the power plant site. Human monitoring, house and food characteristics, individual experience of x-ray exposures, human chromosome analysis and fauna were surveyed and expressed in numerical tables. Chromosome number obtained from the amphibia which were collected around the power plant area was as follows: Kaloula borealis 2N=30, Rana amurensis 2N=26, Rana dybouskii 2N=24, Rana rugosa 2N=26, Rana nigromaculata 2N=26, Rana plancyi 2N=26, Bombina orientalis 2N=24, Hyla arborea 2N=24, Bufo stejnegeri 2N=22, Bufo bufo 2N=22. (author)

  3. Human exposure to high natural background radiation: what can it teach us about radiation risks?

    International Nuclear Information System (INIS)

    Hendry, Jolyon H; Sohrabi, Mehdi; Burkart, Werner; Simon, Steven L; Wojcik, Andrzej; Cardis, Elisabeth; Laurier, Dominique; Tirmarche, Margot; Hayata, Isamu

    2009-01-01

    Natural radiation is the major source of human exposure to ionising radiation, and its largest contributing component to effective dose arises from inhalation of 222 Rn and its radioactive progeny. However, despite extensive knowledge of radiation risks gained through epidemiologic investigations and mechanistic considerations, the health effects of chronic low-level radiation exposure are still poorly understood. The present paper reviews the possible contribution of studies of populations living in high natural background radiation (HNBR) areas (Guarapari, Brazil; Kerala, India; Ramsar, Iran; Yangjiang, China), including radon-prone areas, to low dose risk estimation. Much of the direct information about risk related to HNBR comes from case-control studies of radon and lung cancer, which provide convincing evidence of an association between long-term protracted radiation exposures in the general population and disease incidence. The success of these studies is mainly due to the careful organ dose reconstruction (with relatively high doses to the lung), and to the fact that large-scale collaborative studies have been conducted to maximise the statistical power and to ensure the systematic collection of information on potential confounding factors. In contrast, studies in other (non-radon) HNBR areas have provided little information, relying mainly on ecological designs and very rough effective dose categorisations. Recent steps taken in China and India to establish cohorts for follow-up and to conduct nested case-control studies may provide useful information about risks in the future, provided that careful organ dose reconstruction is possible and information is collected on potential confounding factors.

  4. Human exposure to high natural background radiation: what can it teach us about radiation risks?

    Energy Technology Data Exchange (ETDEWEB)

    Hendry, Jolyon H; Sohrabi, Mehdi; Burkart, Werner [Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna (Austria); Simon, Steven L [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (United States); Wojcik, Andrzej [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Cardis, Elisabeth [Centre for Research in Environmental Epidemiology (CREAL), Municipal Institute of Medical Research (IMIM-Hospital del Mar) and CIBER Epidemiologia y Salud Publica - CIBERESP, Barcelona (Spain); Laurier, Dominique; Tirmarche, Margot [Radiobiology and Epidemiology Department, Radiological and Human Health Division, Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses (France); Hayata, Isamu [National Institute of Radiological Sciences, Chiba (Japan)], E-mail: jhendry2002uk@yahoo.com

    2009-06-01

    Natural radiation is the major source of human exposure to ionising radiation, and its largest contributing component to effective dose arises from inhalation of {sup 222}Rn and its radioactive progeny. However, despite extensive knowledge of radiation risks gained through epidemiologic investigations and mechanistic considerations, the health effects of chronic low-level radiation exposure are still poorly understood. The present paper reviews the possible contribution of studies of populations living in high natural background radiation (HNBR) areas (Guarapari, Brazil; Kerala, India; Ramsar, Iran; Yangjiang, China), including radon-prone areas, to low dose risk estimation. Much of the direct information about risk related to HNBR comes from case-control studies of radon and lung cancer, which provide convincing evidence of an association between long-term protracted radiation exposures in the general population and disease incidence. The success of these studies is mainly due to the careful organ dose reconstruction (with relatively high doses to the lung), and to the fact that large-scale collaborative studies have been conducted to maximise the statistical power and to ensure the systematic collection of information on potential confounding factors. In contrast, studies in other (non-radon) HNBR areas have provided little information, relying mainly on ecological designs and very rough effective dose categorisations. Recent steps taken in China and India to establish cohorts for follow-up and to conduct nested case-control studies may provide useful information about risks in the future, provided that careful organ dose reconstruction is possible and information is collected on potential confounding factors.

  5. Human exposure to high natural background radiation: what can it teach us about radiation risks?

    Science.gov (United States)

    Hendry, Jolyon H; Simon, Steven L; Wojcik, Andrzej; Sohrabi, Mehdi; Burkart, Werner; Cardis, Elisabeth; Laurier, Dominique; Tirmarche, Margot; Hayata, Isamu

    2014-01-01

    Natural radiation is the major source of human exposure to ionising radiation, and its largest contributing component to effective dose arises from inhalation of 222Rn and its radioactive progeny. However, despite extensive knowledge of radiation risks gained through epidemiologic investigations and mechanistic considerations, the health effects of chronic low-level radiation exposure are still poorly understood. The present paper reviews the possible contribution of studies of populations living in high natural background radiation (HNBR) areas (Guarapari, Brazil; Kerala, India; Ramsar, Iran; Yangjiang, China), including radon-prone areas, to low dose risk estimation. Much of the direct information about risk related to HNBR comes from case–control studies of radon and lung cancer, which provide convincing evidence of an association between long-term protracted radiation exposures in the general population and disease incidence. The success of these studies is mainly due to the careful organ dose reconstruction (with relatively high doses to the lung), and to the fact that large-scale collaborative studies have been conducted to maximise the statistical power and to ensure the systematic collection of information on potential confounding factors. In contrast, studies in other (non-radon) HNBR areas have provided little information, relying mainly on ecological designs and very rough effective dose categorisations. Recent steps taken in China and India to establish cohorts for follow-up and to conduct nested case–control studies may provide useful information about risks in the future, provided that careful organ dose reconstruction is possible and information is collected on potential confounding factors. PMID:19454802

  6. Clinical experience of radiation therapy for Graves` ophthalmopathy

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Takeo; Mitsuhashi, Norio; Nagashima, Hisako; Sakurai, Hideyuki; Murata, Osamu; Ishizeki, Kei; Shimaya, Sanae; Hayakawa, Kazushige; Niibe, Hideo [Gunma Univ., Maebashi (Japan). School of Medicine

    1996-11-01

    The effect of radiation therapy for Graves` ophthalmopathy was evaluated. Ten patients with Graves` ophthalmopathy were treated with radiation therapy between 1992 and 1993 in Gunma University Hospital. All patients had a past history of hyperthyroidism and received 2,000 cGy to the retrobulbar tissues in 20 fractions. Nine of ten patients were treated with radiation therapy after the failure of corticosteroids. Six patients (60%) showed good or excellent responses. The exophthalmos type was more responsive to radiation therapy than the double vision type in this series. Two of five patients with the exophthalmos type demonstrated excellent responses, and their symptoms disappeared almost completely. The improvement of symptoms appeared within 3-6 months, and obvious clinical effects were demonstrated after 6 months of radiotherapy. Radiation therapy was well tolerated, and we have not observed any side effects of radiation therapy. In conclusion, radiation therapy is effective treatment for Graves` ophthalmopathy. (author)

  7. Clinical experience of radiation therapy for Graves' ophthalmopathy

    International Nuclear Information System (INIS)

    Takahashi, Takeo; Mitsuhashi, Norio; Nagashima, Hisako; Sakurai, Hideyuki; Murata, Osamu; Ishizeki, Kei; Shimaya, Sanae; Hayakawa, Kazushige; Niibe, Hideo

    1996-01-01

    The effect of radiation therapy for Graves' ophthalmopathy was evaluated. Ten patients with Graves' ophthalmopathy were treated with radiation therapy between 1992 and 1993 in Gunma University Hospital. All patients had a past history of hyperthyroidism and received 2,000 cGy to the retrobulbar tissues in 20 fractions. Nine of ten patients were treated with radiation therapy after the failure of corticosteroids. Six patients (60%) showed good or excellent responses. The exophthalmos type was more responsive to radiation therapy than the double vision type in this series. Two of five patients with the exophthalmos type demonstrated excellent responses, and their symptoms disappeared almost completely. The improvement of symptoms appeared within 3-6 months, and obvious clinical effects were demonstrated after 6 months of radiotherapy. Radiation therapy was well tolerated, and we have not observed any side effects of radiation therapy. In conclusion, radiation therapy is effective treatment for Graves' ophthalmopathy. (author)

  8. Direct Observation of Radiation Defects: Experiment and Interpretation

    International Nuclear Information System (INIS)

    Dudarev, S.L.

    2012-01-01

    at low cost in comparison with the mock-up tests, offer scientific insight and make it possible to perform, in combination with experimental information derived from fission and ion-beam irradiation experiments, the preliminary assessment of power plant operating scenarios. Defining the limits of visibility of small defect clusters and dislocation loops, and optimal diffraction conditions for electron microscope imaging, remains one of the central problems of electron microscopy of irradiated materials. Using computer image simulations based on the propagation- interpolation algorithm for solving the Howie-Basinski equations, it is possible to investigate the relation between the actual and the 'observed' size of small loops, the part played by many-beam dynamical diffraction effects, and limitations of electron microscope imaging in identifying the structure of small defects. A particularly impressive and useful application of electron microscopy is given by recent in situ electron microscope observations, providing real-time visualization of dynamics of defects produced by ultra-high-energy electron irradiation, or showing microstructural evolution occurring under ion beam irradiation. Such observations have revolutionized our understanding of how properties of metals and alloys change in the extreme radiation and thermal environments of a fission or a fusion power plant. The key feature of in situ electron microscopy is its ability to exhibit the time-dependent dynamics of migration, interaction, and transformation of radiation defects, and to visualize the entire complexity of evolving defect and dislocation networks. For example, in situ electron microscope observations provided evidence of violation of the Burgers vector conservation law for dislocations on the nanoscale. This gave a vital clue needed for modeling microscopic processes responsible for the formation of unusual high temperature dislocation structures in iron, and for explaining the origin of the

  9. Human radiation studies: Remembering the early years. Oral history of Biochemist Waldo E. Cohn, Ph.D

    International Nuclear Information System (INIS)

    1995-01-01

    In September 1994, the Department of Energy began an oral history project as part of the Openess initiative on the documentation of the human radiation experiments. This paper presents the oral history of Waldo E Cohn, Ph.D., a Biochemist who worked for the Oak Ridge National Laboratory and the Manhattan Project

  10. The energy balance experiment EBEX-2000. Part III: Behaviour and quality of the radiation measurements

    NARCIS (Netherlands)

    Kohsiek, W.; Liebethal, C.; Foken, T.; Vogt, R.; Oncley, S.P.; Bernhofer, C.; Debruin, H.A.R.

    2007-01-01

    An important part of the Energy Balance Experiment (EBEX-2000) was the measurement of the net radiation and its components. Since the terrain, an irrigated cotton field, could not be considered homogeneous, radiation measurements were made at nine sites using a variety of radiation instruments,

  11. Enforcement of radiation safety standards and experience in the regulatory control of exposures

    Energy Technology Data Exchange (ETDEWEB)

    Krishnamurthi, T N [Health and Safety Div., Atomic Energy Regulatory Board, Mumbai (India)

    1997-11-01

    Regulatory provisions for radiation protection and their enforcement in India are discussed in this paper. The rules and regulations framed for radiation safety cover all the nuclear fuel cycle activities as well as the application of radiation sources in industrial, medical and research institutions. The enforcement aspects and experience in the control of exposures are presented. (author). 3 refs, 2 tabs.

  12. Enforcement of radiation safety standards and experience in the regulatory control of exposures

    International Nuclear Information System (INIS)

    Krishnamurthi, T.N.

    1997-01-01

    Regulatory provisions for radiation protection and their enforcement in India are discussed in this paper. The rules and regulations framed for radiation safety cover all the nuclear fuel cycle activities as well as the application of radiation sources in industrial, medical and research institutions. The enforcement aspects and experience in the control of exposures are presented. (author)

  13. Experimental investigation of radiation effect on human thermal comfort by Taguchi method

    International Nuclear Information System (INIS)

    Arslanoglu, Nurullah; Yigit, Abdulvahap

    2016-01-01

    Highlights: • Radiation heat flux from lighting lamps on human thermal comfort is studied. • The effect of posture position on thermal comfort is investigated. • The effect of clothing color on thermal comfort is examined. • Radiation heat flux from halogen reflector lamp increase skin temperature more. • Posture position effect on thermal comfort is less than the other parameters. - Abstract: In this study, the effect of radiation heat flux of lighting lamps on human thermal comfort was investigated by using Taguchi method. In addition, at indoor conditions, clothing color and posture position under the radiation effect on thermal comfort were also investigated. For this purpose, experiments were performed in an air conditioned laboratory room in summer and autumn seasons. The amount of temperature rise on the back was considered as performance parameter. An L8 orthogonal array was selected as an experimental plan for the third parameters mentioned above for summer and autumn seasons. The results were analyzed for the optimum conditions using signal-to-noise (S/N) ratio and ANOVA method. The optimum results were found to be clear halogen lamp as lighting lamp, white as t-shirt color, standing as posture position, in summer season. The optimum levels of the lighting lamp, t-shirt color and posture position were found to be clear halogen lamp, white, sitting in autumn season, respectively.

  14. Human reactions to electromagnetic radiation in millimeter range

    Energy Technology Data Exchange (ETDEWEB)

    Andreev, E.A.; Belyy, M.U.; Sit' ko, S.P.

    1985-01-01

    The article deals with a problem that is on the boundary of different disciplines. The authors discovered previously unknown effects of low-energy electromagnetic radiation on the human body. A total of 188 subjects, both healthy and sick in terms of medical diagnosis, were submitted to sensory tests. The vast majority of healthy subjects did not react to radiation in the range of 27-78 GHz and power density of up to 10 mW/cm/sup 2/. The same situation was also observed in many cases with patients. However, exposure of very specific parts of the body of sick subjects to electromagnetic waves at a fixed frequency in the range of 45-65 GHz elicited a sensory reaction in the region of the organ with a marked impairment, and this was an organ that was spatially remote from the irradiated region. It was established that the zones on the surface of the body that are the most sensitive to radiation coincide with acupuncture zones that are known in reflex acupuncture therapy. In addition to presentation of experimental results, the authors also propose a theoretical interpretation of the demonstrated effects.

  15. Survival of human lymphocytes after exposure to densely ionizing radiations

    International Nuclear Information System (INIS)

    Madhvanath, U.; Raju, M.R.; Kelly, L.S.

    1976-01-01

    Interphase death of human blood lymphocytes cultured in vitro was studied after exposure to 60 Co gamma rays and to accelerated ions of 1 H, 4 He, 7 Li, 11 B, 12 C, 20 Ne, 40 Ar, and π - meson beam under aerobic conditions. Exposures were also conducted under hypoxic conditions with 60 Co gamma rays, 4 He, 7 Li, and 12 C ion beams. Time course of interphase death was followed for 6 days after irradiation. Percent survivals were determined by using the trypan blue exclusion method. Survival curves at 5 days postirradiation were exponential for all radiations studied. These observations indicate that the production of interphase death of lymphocytes by densely ionizing radiations follows a pattern similar to that observed with colony-forming mammalian cells. However, the reproductive capacity of the latter cells is impaired with maximum effectiveness at energy densities associated with 220 keV/μm for the beam conditions used in this investigation. The much lower energy densities required to kill a lymphocyte suggest that a sensitive structure other than DNA may be responsible for the production of lymphocyte death, perhaps the membranes. The calculated inactivation cross sections for high-LET radiations above 650 keV/μm yielded values larger than the actual cell dimensions. It appears that contributions from delta rays become appreciable in this system at these LET's

  16. Human biodistribution and radiation dosimetry of 82Rb.

    Science.gov (United States)

    Senthamizhchelvan, Srinivasan; Bravo, Paco E; Esaias, Caroline; Lodge, Martin A; Merrill, Jennifer; Hobbs, Robert F; Sgouros, George; Bengel, Frank M

    2010-10-01

    Prior estimates of radiation-absorbed doses from (82)Rb, a frequently used PET perfusion tracer, yielded discrepant results. We reevaluated (82)Rb dosimetry using human in vivo biokinetic measurements. Ten healthy volunteers underwent dynamic PET/CT (6 contiguous table positions, each with separate (82)Rb infusion). Source organ volumes of interest were delineated on the CT images and transferred to the PET images to obtain time-integrated activity coefficients. Radiation doses were estimated using OLINDA/EXM 1.0. The highest mean absorbed organ doses (μGy/MBq) were observed for the kidneys (5.81), heart wall (3.86), and lungs (2.96). Mean effective doses were 1.11 ± 0.22 and 1.26 ± 0.20 μSv/MBq using the tissue-weighting factors of the International Commission on Radiological Protection (ICRP), publications 60 and 103, respectively. Our current (82)Rb dosimetry suggests reasonably low radiation exposure. On the basis of this study, a clinical (82)Rb injection of 2 × 1,480 MBq (80 mCi) would result in a mean effective dose of 3.7 mSv using the weighting factors of the ICRP 103-only slightly above the average annual natural background exposure in the United States (3.1 mSv).

  17. Calibration and application of medical particle accelerators to space radiation experiments

    International Nuclear Information System (INIS)

    Ryu, Kwangsun; Park, Miyoung; Chae, Jangsoo; Yoon, Sangpil; Shin, Dongho

    2012-01-01

    In this paper, we introduce radioisotope facilities and medical particle accelerators that can be applied to space radiation experiments and the experimental conditions required by the space radiation experiments. Space radiation experiments on the ground are critical in determining the lifetimes of satellites and in choosing or preparing the appropriate electrical parts to assure the designated mission lifetime. Before the completion of building the 100-MeV proton linear accelerator in Gyeongju, or even after the completion, the currently existing proton accelerators for medical purposes could suggest an alternative plan. We have performed experiments to calibrate medical proton beam accelerators to investigate whether the beam conditions are suitable for applications to space radiation experiments. Based on the calibration results, we propose reference beam operation conditions for space radiation experiments.

  18. Infrared A radiation promotes survival of human melanocytes carrying ultraviolet radiation-induced DNA damage.

    Science.gov (United States)

    Kimeswenger, Susanne; Schwarz, Agatha; Födinger, Dagmar; Müller, Susanne; Pehamberger, Hubert; Schwarz, Thomas; Jantschitsch, Christian

    2016-06-01

    The link between solar radiation and melanoma is still elusive. Although infrared radiation (IR) accounts for over 50% of terrestrial solar energy, its influence on human skin is not well explored. There is increasing evidence that IR influences the expression patterns of several molecules independently of heat. A previous in vivo study revealed that pretreatment with IR might promote the development of UVR-induced non-epithelial skin cancer and possibly of melanoma in mice. To expand on this, the aim of the present study was to evaluate the impact of IR on UVR-induced apoptosis and DNA repair in normal human epidermal melanocytes. The balance between these two effects is a key factor of malignant transformation. Human melanocytes were exposed to physiologic doses of IR and UVR. Compared to cells irradiated with UVR only, simultaneous exposure to IR significantly reduced the apoptotic rate. However, IR did not influence the repair of UVR-induced DNA damage. IR partly reversed the pro-apoptotic effects of UVR via modification of the expression and activity of proteins mainly of the extrinsic apoptotic pathway. In conclusion, IR enhances the survival of melanocytes carrying UVR-induced DNA damage and thereby might contribute to melanomagenesis. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. Effect of ionizing radiation on human skeletal muscle precursor cells

    International Nuclear Information System (INIS)

    Jurdana, Mihaela; Cemazar, Maja; Pegan, Katarina; Mars, Tomaz

    2013-01-01

    Long term effects of different doses of ionizing radiation on human skeletal muscle myoblast proliferation, cytokine signalling and stress response capacity were studied in primary cell cultures. Human skeletal muscle myoblasts obtained from muscle biopsies were cultured and irradiated with a Darpac 2000 X-ray unit at doses of 4, 6 and 8 Gy. Acute effects of radiation were studied by interleukin – 6 (IL-6) release and stress response detected by the heat shock protein (HSP) level, while long term effects were followed by proliferation capacity and cell death. Compared with non-irradiated control and cells treated with inhibitor of cell proliferation Ara C, myoblast proliferation decreased 72 h post-irradiation, this effect was more pronounced with increasing doses. Post-irradiation myoblast survival determined by measurement of released LDH enzyme activity revealed increased activity after exposure to irradiation. The acute response of myoblasts to lower doses of irradiation (4 and 6 Gy) was decreased secretion of constitutive IL-6. Higher doses of irradiation triggered a stress response in myoblasts, determined by increased levels of stress markers (HSPs 27 and 70). Our results show that myoblasts are sensitive to irradiation in terms of their proliferation capacity and capacity to secret IL-6. Since myoblast proliferation and differentiation are a key stage in muscle regeneration, this effect of irradiation needs to be taken in account, particularly in certain clinical conditions

  20. Effects of flow gradients on directional radiation of human voice.

    Science.gov (United States)

    Pulkki, Ville; Lähivaara, Timo; Huhtakallio, Ilkka

    2018-02-01

    In voice communication in windy outdoor conditions, complex velocity gradients appear in the flow field around the source, the receiver, and also in the atmosphere. It is commonly known that voice emanates stronger towards the downstream direction when compared with the upstream direction. In literature, the atmospheric effects are used to explain the stronger emanation in the downstream direction. This work shows that the wind also has an effect to the directivity of voice also favouring the downstream direction. The effect is addressed by measurements and simulations. Laboratory measurements are conducted by using a large pendulum with a loudspeaker mimicking the human head, whereas practical measurements utilizing the human voice are realized by placing a subject through the roof window of a moving car. The measurements and a simulation indicate congruent results in the speech frequency range: When the source faces the downstream direction, stronger radiation coinciding with the wind direction is observed, and when it faces the upstream direction, radiation is not affected notably. The simulated flow gradients show a wake region in the downstream direction, and the simulated acoustic field in the flow show that the region causes a wave-guide effect focusing the sound in the direction.

  1. The sensitivity of human mesenchymal stem cells to ionizing radiation

    International Nuclear Information System (INIS)

    Chen, M.-F.; Lin, C.-T.; Chen, W.-C.; Yang, C.-T.; Chen, C.-C.; Liao, S.-K.; Liu, J.M.; Lu, C.-H.; Lee, K.-D.

    2006-01-01

    Purpose: Recent studies have shown that mesenchymal stem cells (MSCs) obtained from bone marrow transplantation patients originate from the host. This clinical observation suggests that MSCs in their niches could be resistant to irradiation. However, the biologic responses of bone marrow MSCs to irradiation have rarely been described in the literature. Methods and Materials: In this study, human bone marrow-derived, clonally expanded MSCs were used to investigate their sensitivity to irradiation in vitro, and the cellular mechanisms that may facilitate resistance to irradiation. The human lung cancer cell line A549 and the breast cancer cell line HCC1937 were used as controls for radiosensitivity; the former line has been shown to be radioresistant and the latter radiosensitive. We then examined their in vitro biologic changes and sensitivities to radiation therapy. Results: Our results suggest that MSCs are characterized as resistant to irradiation. Several cellular mechanisms were demonstrated that may facilitate resistance to irradiation: ATM protein phosphorylation, activation of cell-cycle checkpoints, double-strand break repair by homologous recombination and nonhomologous end joining (NHEJ), and the antioxidant capacity for scavenging reactive oxygen species. Conclusions: As demonstrated, MSCs possess a better antioxidant reactive oxygen species-scavenging capacity and active double-strand break repair to facilitate their radioresistance. These findings provide a better understanding of radiation-induced biologic responses in MSCs and may lead to the development of better strategies for stem cell treatment and cancer therapy

  2. The recovery of the human organism after radiation exposure

    International Nuclear Information System (INIS)

    Gerber, G.B.

    1976-01-01

    The repair of radiation damage in the human organism is reviewed. A distinction is made between the single repair steps, first the molecular repair of sublethal damage during the periods of 30 min to 2 h and several days to months, second the substitution of the whole cells during a period of reproduction which is specific for the kind and persistence of the cells. One example is the radiosensitive stem cell with a reproduction rate of 40% and a redoublication time of 10 d at 100 rads and the very low reproduction rate of 1% with redoublication time of 7 d after a dose of 400 rads. 5 rads seems to be acceptable for systems with recovery and repeated exposure, single doses normally should not exceed 25 rads, not 100 rads/d for to save human life, and not a total dose of 500 rads. About 20% of irradiation damage is not repaired and leads to late effects, for example the induction of tumors, the shortening of life span and an increase in embryonic mortality. The author recommends the acceptance of a radiation dose leading to 20 additional cases of leucemia in the whole population of Germany and an increase of tumor frequency of 1%. The shortening of life span should not exceed 0,5%. The equivalent residual dose (ERD) can be calculated by the following equation: ERD = last effective dose minus 5 rads x number of days. (AJ) [de

  3. Own experiences in genetic counselling of radiation exposed persons

    International Nuclear Information System (INIS)

    Laude, G.; Bruening, L.

    1995-01-01

    An outline is given of genetic counselling provided to 46 radiation-exposed persons during the period from 1978 to 1994. The radiation exposure had, in most cases, been due to radiation-therapeutic measures (n=22). To a low extent, counselling was carried out because of fear of genetic consequences of the Chernobyl reactor accident (n=11), preceding radiation exposure from X-ray (n=9) and nuclear diagnosis (n=1) as well as occupation radiation exposure (n=3). During counselling, information was given on the genetic risk to be expected, taking into consideration the risk factor that is valid at present and the malformation doubling dose. After performance of radiation therapy, an avoidance of conception for 2 years has been recommended. After termination of this period, in the case of an urgent wish of having children, pregnancy was not discouraged if no further risk factors existed. (orig.) [de

  4. Characterization of ionizing radiation effects on human skin allografts

    International Nuclear Information System (INIS)

    Bourroul, Selma Cecilia

    2004-01-01

    The skin has a fundamental role in the viability of the human body. In the cases of extensive wounds, allograft skin provides an alternative to cover temporarily the damaged areas. After donor screening and preservation in glycerol (above 85%), the skin can be stored in the Skin Banks. The glycerol at this concentration has a bacteriostatic effect after certain time of preservation. On the other hand, skin sterilization by ionizing radiation may reduces the quarantine period for transplantation in patients and its safety is considered excellent. The objectives of this work were to establish procedures using two sources of ionizing radiation for sterilization of human skin allograft, and to evaluate the skin after gamma and electron beam irradiation. The analysis of stress-strain intended to verify possible effects of the radiation on the structure of preserved grafts. Skin samples were submitted to doses of 25 kGy and 50 kGy in an irradiator of 60 Co and in an electron beam accelerator. Morphology and ultra-structure studies were also accomplished. The samples irradiated with a dose of 25 kGy seemed to maintain the bio mechanic characteristics. The gamma irradiated samples with a dose of 50 kGy and submitted to an electron beam at doses of 25 kGy and 50 kGy presented significant differences in the values of the elasticity modulus, in relation to the control. The analysis of the ultramicrographies revealed modifications in the structure and alterations in the pattern of collagen fibrils periodicity of the irradiated samples. (author)

  5. Cosmic radiation induced chromosomal aberrations in human lymphocytes

    International Nuclear Information System (INIS)

    De Angelis, G.; Facius, R.; Reitz, G.

    2003-01-01

    Since decades, elevated frequencies of dicentric chromosomes (DIC) in human lymphocytes have successfully been used as a biological dosimeter in cases of acute, often accidental exposures to ionizing radiation. As long as duration and time lags after exposure are small compared to the lifetime of DIC, their frequencies can also be used to assess doses from protracted, chronic irradiation. E.g., within the substantial range of uncertainties, the frequencies of DIC observed in cosmonauts are compatible with the frequencies expected from doses of low and high LET radiation to which they were exposed in low earth orbit (LEO). On the other hand, frequencies of DIC detected in lymphocytes of civilian aviation crewmembers rarely correlate with the doses accumulated all along their professional career. For such long duration exposures with relatively low induction rates, the concomitant decay of DIC frequencies due to the removal during exposure of lymphocytes carrying DIC has to be taken into account. We present temporal profiles of frequencies of DIC during the exposure calculated with a model of exponential decay of DIC for some scenarios of chronic exposure to cosmic radiation. E.g., even after a 'heavily' shielded Mars mission, the expected frequencies of DIC in lymphocytes of astronauts will be 10 to 40 times higher than the terrestrial control levels. For air flight personnel we calculated the time profiles of frequencies of DIC in lymphocytes of a 'typical' pilot, a male cabin attendant and a female cabin attendant whose professional radiation exposures were recalculated for the actual flight routes flown during their entire flight career as recorded in detailed duty logs. These results demonstrate that experimental (epidemiological) studies concerning DIC in air or space flight personnel must explicitly take into consideration the temporal exposure profiles in the prospective study population and that the point in time at which blood samples are to be drawn must

  6. Dosimetry Methods for Human Exposure to Non-Ionising Radiation

    International Nuclear Information System (INIS)

    Poljak, D.; Sarolic, A.; Doric, V.; Peratta, C.; Peratta, A.

    2011-01-01

    The paper deals with human exposure to electromagnetic fields from extremely low frequencies (ELF) to GSM frequencies. The problem requires (1) the assessment of external field generated by electromagnetic interference (EMI) source at a given frequency (incident field dosimetry) and then (2) the assessment of corresponding fields induced inside the human body (internal field dosimetry). Several methods used in theoretical and experimental dosimetry are discussed within this work. Theoretical dosimetry models at low frequencies are based on quasistatic approaches, while analyses at higher frequencies use the full-wave models. Experimental techniques involve near and far field measurement. Human exposure to power lines, transformer substations, power line communication (PLC) systems, Radio Frequency Identification (RFID) antennas and GSM base station antenna systems is analyzed. The results o are compared to the exposure limits proposed by relevant safety guidelines. Theoretical incident dosimetry used in this paper is based on the set of Pocklington integro-differential equations for the calculation of the current distribution and subsequently radiated field from power lines. Experimental incident dosimetry techniques involve measurement techniques of fields radiated by RFID antennas and GSM base station antennas. First example set of numerical results is related to the internal dosimetry of realistic well-grounded body model exposed to vertical component of the electric field E = 10 kV/m generated by high voltage power line. The results obtained via the HNA model exceed the ICNIRP basic restrictions for public exposure (2 mA/m 2 ) in knee (8.6 mA/m 2 ) and neck (9.8 mA/m 2 ) and for occupational exposure (10 mA/m 2 ) in ankle (32 mA/m 2 ). In the case of a conceptual model of a realistic human body inside a transformer substation room touching a control panel at the potential φ0 = 400 V and with two scenarios for dry-air between worker's hand and panel, the values

  7. Radiation response characteristics of human cell in vitro

    International Nuclear Information System (INIS)

    Hall, E.J.

    1987-01-01

    Improvements in tissue culture techniques and growth media have made it possible to culture a range of cells of human origin, both normal and malignant. The most recent addition to the list are endothelial cells. Interesting results have been obtained, some of which may have implications in Radiation Therapy. (i) Repair of Potentially Lethal Damage (PLDR) has been observed in all cell lines investigated; cells of normal origin repair PLD at least as well as malignant cells, which makes clinical trials of PLDR inhibitors of doubtful usefulness. (ii) PLD in fibroblasts of human origin appears to have a component that is repaired rapidly, in a matter of minutes, as well as a slower component that takes hours to repair. (iii) Sublethal damage repair, manifest by a dose-rate effect, has also been observed in all human cell lines tested. Cells of normal tissue origin, including fibroblasts and endothelial cells, exhibit a dose-rate effect that is intermediate between that for cells from traditionally resistant tumors (melanoma and osteosarcoma) and cells from more sensitive tumors (neuroblastoma and breast). (iv) Fibroblasts from patients with Ataxia Telangectasia (AT) are much more sensitive to x-rays, with a D/sub o/ about half that for normal human fibroblasts. Nevertheless repair of both PLD and SLD can be demonstrated in these cells

  8. Comparative aspects of animal and human data on somatic effects of ionizing radiation

    International Nuclear Information System (INIS)

    Matsuoka, Osamu; Kobayashi, Sadayoshi

    1986-10-01

    This report contains presentations at the 17th Symposium organized by the National Institute of Radiological Sciences, which took place in Chiba, Japan, from 11 to 12 December 1985. Unlike in the previous symposiums dealing with cellular and molecular levels, the present symposium discussed somatic effects of ionizing radiation at the organic level in conjunction with epidemiological data. This report is divided into five sections: the first is explanation for UNSCEAR's and ICRP's views of human and animal data in the current assessment of radiation health risks; the second covers comparison of epidemiological and animal experimental data on the dose-effect relationship for carcinogenesis, together with problems in epidemiological and experimental studies; the third discusses significance and problems in animal experiments on modifying factors of radiation carcinogenesis; the fourth deals with studies on carcinogenesis mechanism, aiming at elucidating their significance and potential role in the risk evaluation for humans; and the last section is a compilation of panel discussion of differences in humans and animals, giving a proposal for future research. (Namekawa, K.)

  9. Parenting experiences of couples living with human ...

    African Journals Online (AJOL)

    Belinda Chimphamba Gombachika

    2014-05-12

    May 12, 2014 ... qualitative study was to explore and describe parenting experiences of seroconcordant couples who have a child while living with HIV in Malawi. .... 2008). This development raises issues not yet much explored; par- ..... sible for instituting and maintaining life style changes necessary to reduce risk and ...

  10. Pioneer 10/11 data analysis of the trapped radiation experiment

    Science.gov (United States)

    Fillius, W.

    1982-01-01

    The data handling operations and the database produced by the Trapped Radiation Experiment on the NASA Pioneer 10 and 11 spacecraft are outlined. In situ measurements of trapped radiation at both Jupiter and Saturn, the extension of cosmic ray observations to the outer heliosphere, the presence of Jovian electrons in interplanetary space, analyses of the interaction between planetary satellites and the trapped radiation that engulfs them, and further investigations of the radiation enviroments of both planets are reported.

  11. New way to rise estimation objectivity of radiation consequences on human

    International Nuclear Information System (INIS)

    Akhmatullina, N. B.

    2001-01-01

    conditions both acute and chronic exposure (Breven e.a.1977, Lloyd e.a.1983). Correctness of such approach was approved by the results of our many years researches as well. It was found that inhabitants of the Semipalatinsk TS had the part of chromosome aberrations which was higher in many times than chromatide (fig.1,2), but in Priaral the situation was opposite. More perspective from the point of view of biologic dosimetry and verification of radiation damages is molecular cytogenetic method of the analysis of the frequences all types aberrations, especially more rare stable aberrations - simmetric translocations. The method is based on the fluorescent label of chromosomes after hybridisation in situ metaphase preparations with chromospecific DNA - probes (FISH- method). This method in spite of the complication and expensiveness is much more effective than the direct cytogenetic analysis. The essense of the our approach consists in the broadening of the analysed primary genetic effects spectrum, using not only FISH-analysis but also other achievements of modern genetics, particularly Radiation Adaptive Response (RAR) which wasn't found the use yet in the researches of radiation consequenses on human. RAR is known as new type of inducible non-prone repair, which leads to the forming of genetic mechanisms of the cells defence by low preexposure doses. RAR also can be used as the double test. We have studied it both in vitro and in vivo (table). Experiments showed that after preirradiation by 0,05 Gy of g- rays the cells of practically healthy people are getting essential and statistical reliable genetic defence from post exposure to high doses (2 Gy). On the contrary the cells of cohorts of people professionaly exposed to radiation endured very well irradiation by high dose without preirradiation. Thus objectiveness of estimations in our approach flows out not only of analysis of negative but also positive radiation effects on human. This method makes possible: a) to

  12. Researching Human Experience: video intervention/prevention assessment (VIA

    Directory of Open Access Journals (Sweden)

    Jennifer Patashnick

    2005-05-01

    Full Text Available Human experience is a critical subject for research. By discussing Video Intervention/Prevention Assessment (VIA, a patient-centered health research method where patients teach their clinicians about living with a chronic condition through the creation of visual illness narratives, this paper examines the value of qualitative inquiry and why human experience rarely is investigated directly. An analysis of a sample VIA data is presented to demonstrate how, by utilizing grounded theory and qualitative analysis, one can derive rich and unique information from human experience.

  13. Human radiation studies: Remembering the early years. Oral history of physiologist Nello Pace, Ph.D., August 16, 1994

    International Nuclear Information System (INIS)

    1995-06-01

    Dr. Nello Pace was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). Dr. Pace was selected fro the interview because of the positions he held with the US Navy, at the University of California, Berkeley, and as Director of the White Mountain Research Station near Bishop, California. Following a brief biographical sketch, Dr. Pace related his remembrances concerning tritium injections experiments in animals and humans during World War II, the development of Medical Physics Degree Programs at UC Berkeley, conducting the first radiation survey at Nagasaki after the bomb, and the establishment of a research laboratory at White Mountain. He also offers reflections on Shields Warren and comments on the public's attitudes towards radiation both then and now

  14. Clinical experience in 89 consecutive cases of chronic radiation enterocolitis

    Directory of Open Access Journals (Sweden)

    Ming-Cheng Chen

    2011-02-01

    Conclusions: We confirmed that as compared with recently developed innovative techniques, early primitive radiotherapy techniques were associated with more severe radiotherapy complications that required surgery. Smoking may enhance patients’ vulnerability to severe radiation injury. Surgery for radiation-induced intestinal obstruction, intestinal fistula and perforation is warranted because QOL, serum albumin level and body mass index were similar between the surgical and nonsurgical groups.

  15. Human radiation studies: Remembering the early years. Oral history of biochemist John Randolph Totter, Ph.D., January 23, 1995

    International Nuclear Information System (INIS)

    1995-09-01

    This document is a transcript of an interview of Dr. John Randolph Tottler by representatives of the US DOE Office of Human Radiation Experiments. Dr. Tottler was selected for this interview because of his career with the Atomic Energy Commission Division of Biology and Medicine (DBM), particularly as its director from 1967 to 1972. After a short biographical sketch Dr. Tottler discusses his remembrances on a wide range topics including nucleic acid and leukemia research at Oak Ridge, AEC biochemistry training in South America, DBM's research focus on radiation effects, early leadership of DBM, relations with the US Public Health Service, controversies on low-level radiation, iodine from fallout, on John Gofman, and Project Plowshare, funding for AEC Research Programs and for international research, testicular irradiation of prisoners in Washington State and Oregon, Plutonium injections, ethics of government radiation research, and opinions of public misperceptions about radiation and cancer

  16. A spectroscopic study on the effect of ultra-violet solar radiation in Antarctica on the human skin fibroblast cells

    Directory of Open Access Journals (Sweden)

    Tatsuyuki Yamamoto

    2013-11-01

    Full Text Available A study on the effect of the solar ultra-violet radiation on the human skin fibroblast cells revealed that the production of matrix metalloproteinase-2 was inhibited by the radiation. A CO2 incubator connected by optical fibers to a reflector telescope for collecting the solar light was built at Syowa station by the 49th Japanese Antarctica Research Expedition. The direction of the telescope was continuously controlled by a sun-tracker to follow the movement of the Sun automatically. The intensity of the collected light was monitored by a portable spectrophotometer housed inside. The human skin fibroblast cells were incubated in the CO2 chamber to investigate the effect of the solar radiation at Syowa station and were compared with those reference experiments at a laboratory in Japan. The results showed cell damage by strong UV radiation. The production of matrix metalloproteinase-2 was prompted by the moderate UV-B, but was inhibited by the strong UV-B radiation, as studied under laboratory conditions in Japan. The effect of strong solar radiation at Syowa station involving the radiation of UV-B region was estimated to be of the same extent of the radiation caused by an artificial UV-B light with the intensity more than 50 mJ/cm2.

  17. Experiments on the emergence of human communication.

    Science.gov (United States)

    Steels, Luc

    2006-08-01

    Children learn language from their parents and then use the acquired system throughout the rest of their life with little change. At least that is commonly assumed. But a recent paper by Galantucci adds to the growing evidence that adults (and children) are able to create and negotiate complex communication systems from scratch and relatively quickly, without a prior model. This raises questions of what cognitive mechanisms are implied in this joint construction of communication systems, and what the implications are for the origins of human language.

  18. Nonionising radiation and risk of human cancer: comparison of ultraviolet and radiofrequency radiation

    International Nuclear Information System (INIS)

    Green, A.

    2003-01-01

    Human exposure to ultraviolet radiation (UVR) comes largely from sunlight, although a small proportion of people receive high dose UVR from artificial sources. The causal link between solar UVR and the keratinocyte cancers, basal cell carcinomas and squamous cell carcinomas of the skin, is well-established based on a large body of observational and experimental evidence. UVR damages molecules such as DNA directly and this is the principal mechanism of carcinogenesis, though other mechanisms such as immunosuppression and interaction with viruses may also be involved. People are also exposed to another form of nonionising radiation, radiofrequency radiation (RFR), through occupation, the community environment from base stations, and through use of cellular telephones and related communications devices. However, unlike UVR, the relationship between RFR and cancer is far from clear. The main tumours that have been investigated to date are brain tumours and leukaemia but assessing the RFR exposure pathway to such cancers poses many methodological challenges for epidemiologists. Refinements to measurement of exposure are the major urgent need, and the lack of evidence regarding carcinogenic effects of RFR in experimental settings complicates the assessment. Further insights into the links between RFR and chronic disease such as cancer are likely in the next few years however when results of several large-scale epidemiological studies now in train around the world become available

  19. The Human Experience With Ghrelin Administration

    Science.gov (United States)

    Garin, Margaret C.; Burns, Carrie M.; Kaul, Shailja

    2013-01-01

    Context: Ghrelin is an endogenous stimulator of GH and is implicated in a number of physiological processes. Clinical trials have been performed in a variety of patient populations, but there is no comprehensive review of the beneficial and adverse consequences of ghrelin administration to humans. Evidence Acquisition: PubMed was utilized, and the reference list of each article was screened. We included 121 published articles in which ghrelin was administered to humans. Evidence Synthesis: Ghrelin has been administered as an infusion or a bolus in a variety of doses to 1850 study participants, including healthy participants and patients with obesity, prior gastrectomy, cancer, pituitary disease, diabetes mellitus, eating disorders, and other conditions. There is strong evidence that ghrelin stimulates appetite and increases circulating GH, ACTH, cortisol, prolactin, and glucose across varied patient populations. There is a paucity of evidence regarding the effects of ghrelin on LH, FSH, TSH, insulin, lipolysis, body composition, cardiac function, pulmonary function, the vasculature, and sleep. Adverse effects occurred in 20% of participants, with a predominance of flushing and gastric rumbles and a mild degree of severity. The few serious adverse events occurred in patients with advanced illness and were not clearly attributable to ghrelin. Route of administration may affect the pattern of adverse effects. Conclusions: Existing literature supports the short-term safety of ghrelin administration and its efficacy as an appetite stimulant in diverse patient populations. There is some evidence to suggest that ghrelin has wider ranging therapeutic effects, although these areas require further investigation. PMID:23533240

  20. Radiations

    International Nuclear Information System (INIS)

    Pujol Mora, J.

    1999-01-01

    The exposition to ionizing radiations is a constant fact in the life of the human being and its utilization as diagnostic and therapeutic method is generalized. However, it is notorious how as years go on, the fear to the ionizing radiation seems to persist too, and this fact is not limited to the common individual, but to the technical personnel and professional personnel that labors with them same. (S. Grainger) [es

  1. The Biostack experiment as an approach to high LET radiation research

    International Nuclear Information System (INIS)

    Hildebrand, D.; Buecker, H.; Facius, R.; Schaefer, M.; Toth, B.; Ruether, W.; Pfohl, R.; Kaiser, R.

    1976-01-01

    The investigation of biological effects of the penetrating cosmic radiation enforced new experimental techniques, not only to be used in space experiments, but according to theoretical considerations in accelerator experiments as well. Localization and individual evaluation are the main tools for the reduction of the sample space, which allows together with the multiple factorial analysis investigations in a ''dose'' region that is off limits for classical radiobiology. The results of the Biostack experiments proved that there is a serious radiation hazard during longer space flights, which we should be aware of under the aspects of radiation protection and consideration in biological experiments (investigating weightlessness as example)

  2. Enhancement of radiation response in human hepatocarcinoma cells by Metformin

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Eun Ho; Kim, Won Woo; Kim, Joon; Jung, Won Gyun [Division of heavy ion clinical research, Korea University, Seoul (Korea, Republic of); Jeong, Jae Hoon; Jeong, Youn Kyoung; Kim, Mi Sook [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2012-11-15

    Metformin (1, 1-dimethylbiguanide hydrochloride), the most widely used drug to treat type 2 diabetic patients under benefit good tolerability profile and low cost, has sparked keen interest as potential anticancer agent. Preclinical studies showed that the primary mechanism of action of metformin is through its ability to activate AMP-activated protein kinase (AMPK). Metformin inhibits complex 1 in the mitochondrial electron transport chain, leading to an increase in the AMP-to-ATP ratio, then, phospholylated AMPK increase energy generation or suppress energy consumption and then, inhibits cell growth. However, important caveat in direct action theory of metformin is that millimorlar range, effective dose for inhibition tumor cell growth in vitro, cannot be achieved in patients. This is probably because metformin enter cells through the organic cation transporters OCT1 and OCT2, which is lowly expressed in human cells except liver and adipose cells. dependent pathway rather than through direct effects of the tumor cells. We analyzed combination effect of metformin and radiation focusing to HCC cell lines, which theoretically express high organic cation transporters, producing high centration of metformin in tumor cells. The purpose of this study is to investigate whether metformin had anti-tumor effects when combined with radiation as radiosensitizer in HCC. The results showed that metformin increased radiosensitizing efficacy in HCC cells , as well as in Huh7 xenograft mouse models. Interestingly, metformin effectively sensitizes IR-induced apoptosis in HCC through upregulation of cleaved PARP and caspase3 and increase synergically on DNA damage response with combined treatment.HCC, suggesting potential usefulness of combined therapy of metformin together with radiation for HCC cancer therapy.

  3. Cytotoxic effects of radiation and docetaxel in human tumour cells

    International Nuclear Information System (INIS)

    Dunne, A.L.

    2000-12-01

    Data from both single institutions and from randomised multicentre trials have demonstrated that the combination of chemotherapy with radiotherapy can increase the survival of cancer patients. Treatment regimens consisting of taxanes (paclitaxel and docetaxel), a potent class of new chemotherapeutic agents, combined with radiotherapy have recently undergone preclincal investigation. Overall, these studies show that taxanes can enhance the radiation sensitivity of tumour cells. However, data on docetaxel is very limited and the mechanism of radiosensitisation by docetaxel remains largely unknown. The chief purpose of this thesis was to investigate the ability of docetaxel to radiosensitise human tumour cells and investigate potential mechanisms for radiosensitisation. The results reported here for docetaxel indicate that for the cell fines examined this drug does have a synergistic effect and is thus a radiosensitising agent. The degree of radiosensitisation seen seems to be largely dependent on drug concentration. A mechanism involving docetaxel potentiation of radiation-induced apoptosis is also suggested. The second purpose of this thesis is to investigate the potential usefulness of an apoptosis assay and the comet assay as biological indicators for cellular radiosensitivity. Many scientists and clinicans have highlighted the need for development of new rapid, predictive assays of radiation responses. If the radiosensitivity of tumours could be predicted, it may eventually allow the individualisation of patient treatment by radiotherapy. In summary, initial DNA damage measured using the comet assay was successful in predicting the radiosensitivity of colorectal tumour cells. The results suggest that the comet assay appears more suitable than the detection of apoptosis for the prediction of radiosensitivity. We conclude that the results obtained from this thesis will contribute to the current attempts to improve the radiotherapeutic management of cancer. (author)

  4. Enhancement of radiation response in human hepatocarcinoma cells by Metformin

    International Nuclear Information System (INIS)

    Kim, Eun Ho; Kim, Won Woo; Kim, Joon; Jung, Won Gyun; Jeong, Jae Hoon; Jeong, Youn Kyoung; Kim, Mi Sook

    2012-01-01

    Metformin (1, 1-dimethylbiguanide hydrochloride), the most widely used drug to treat type 2 diabetic patients under benefit good tolerability profile and low cost, has sparked keen interest as potential anticancer agent. Preclinical studies showed that the primary mechanism of action of metformin is through its ability to activate AMP-activated protein kinase (AMPK). Metformin inhibits complex 1 in the mitochondrial electron transport chain, leading to an increase in the AMP-to-ATP ratio, then, phospholylated AMPK increase energy generation or suppress energy consumption and then, inhibits cell growth. However, important caveat in direct action theory of metformin is that millimorlar range, effective dose for inhibition tumor cell growth in vitro, cannot be achieved in patients. This is probably because metformin enter cells through the organic cation transporters OCT1 and OCT2, which is lowly expressed in human cells except liver and adipose cells. dependent pathway rather than through direct effects of the tumor cells. We analyzed combination effect of metformin and radiation focusing to HCC cell lines, which theoretically express high organic cation transporters, producing high centration of metformin in tumor cells. The purpose of this study is to investigate whether metformin had anti-tumor effects when combined with radiation as radiosensitizer in HCC. The results showed that metformin increased radiosensitizing efficacy in HCC cells , as well as in Huh7 xenograft mouse models. Interestingly, metformin effectively sensitizes IR-induced apoptosis in HCC through upregulation of cleaved PARP and caspase3 and increase synergically on DNA damage response with combined treatment.HCC, suggesting potential usefulness of combined therapy of metformin together with radiation for HCC cancer therapy

  5. Human otolith function, experiment M009

    Science.gov (United States)

    Graybiel, A.; Miller, E. F., II

    1971-01-01

    The experiments that were performed during the Gemini 5 and 7 missions resulted in quantitative information concerning otolithic function and orientation of four subjects exposed to an orbiting spacecraft environment for prolonged periods of time. Preflight counterrolling measurements revealed significant differences between crewmembers with regard to the basic magnitude of otolith response. However, after the flight, each crewmember maintained his respective preflight level of response. This was indicative that no significant change in otolithic sensitivity occurred as a result of the flight, or at least no change persisted long enough to be recorded several hours after recovery. The EVLH data recorded for each subject confirmed the observation that a coordinate space sense exists even in a weightless environment if contact cues are adequate. However, it was noted that the apparent location of the horizontal within the spacecraft may not agree necessarily with its physical correlate in the spacecraft.

  6. John Dewey on philosophy of experience and human education

    Directory of Open Access Journals (Sweden)

    Darcísio Natal Muraro

    2017-08-01

    Full Text Available The objective of this study is to investigate the conception of philosophy and its relation to human formation in the thinking of John Dewey. The work aimed at analyzing the concepts in the main works of the author and his interpreters. The paper analyzes the reconstruction of philosophy as a philosophy of experience anchored in the genetic, experimental, reflexive, critical and creative method. The philosophy of experience is opposed to the dualisms and the spectator philosophies of knowledge that maintains the social division into classes. The role of the philosophy of experience is to rationalize through inquiry the possibilities of human experience through the critical reconstruction of the meanings. The philosophy of experience is a condition of possibility for democratic life and for an education based on freedom and human emancipation.

  7. Effects of ionizing radiation on the human body

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    The effects of ionizing radiation on the human body are the consequences of biological ones. They have been observed from the first few years after the discovery of X-rays and radioactivity: between 1902 and 1907, 170 cases of various lesions attributable to radiation were described. The pathological manifestations which result from a radio-exposure are of two kinds: short-term effects which inevitably occur after certain thresholds have been exceeded. More often than not they are reversible, their severity being a function of the dose; and delayed effects, slowly evolving, apparently random, more often than not irreversible. Here it is not the severity but the probability of their appearance which is proportional to the dose. It is, at the present time, impossible statistically, to prove the existence or non-existence of thresholds for delayed effect; thus, in the fixing of norms, the ICRP has cautiously chosen the hypothesis of the absence of thresholds, assuming a linear dose/effect relationship. This has probably led to an over-estimation of the risks associated with weak doses. Radio-exposure can be total, affecting the entire body, or may be localized in all or part of a specific organ or tissue

  8. Transvenous coronary angiography in humans with synchrotron radiation

    Energy Technology Data Exchange (ETDEWEB)

    Thomlinson, W.

    1994-10-01

    The transvenous coronary angiography project at the National Synchrotron Light Source (NSLS) is presently undergoing a significant upgrade to the hardware and software in the synchrotron medical facility. When completed, the project will have reached a level of maturity in the imaging technology which will allow the research team to begin to concentrate on medical research programs. This paper will review the status of the project and imaging technology and will discuss the current upgrades and future advanced technology initiatives. The advantages of using the radiation from a synchrotron, over that from a standard x-ray source, were the motivation for the project. A total of 23 human imaging sessions have been carried out with in the project. The primary goals have been to establish the imaging parameters and protocol necessary to obtain clinically useful images.

  9. Transvenous coronary angiography in humans with synchrotron radiation

    International Nuclear Information System (INIS)

    Thomlinson, W.

    1994-01-01

    The transvenous coronary angiography project at the National Synchrotron Light Source (NSLS) is presently undergoing a significant upgrade to the hardware and software in the synchrotron medical facility. When completed, the project will have reached a level of maturity in the imaging technology which will allow the research team to begin to concentrate on medical research programs. This paper will review the status of the project and imaging technology and will discuss the current upgrades and future advanced technology initiatives. The advantages of using the radiation from a synchrotron, over that from a standard x-ray source, were the motivation for the project. A total of 23 human imaging sessions have been carried out with in the project. The primary goals have been to establish the imaging parameters and protocol necessary to obtain clinically useful images

  10. Human exposure to ionizing radiation for medical reasons

    International Nuclear Information System (INIS)

    Thomas, R.H.; Busick, D.D.

    1977-01-01

    The central issue in this debate is not whether there is a threshold dose below which deleterious effects in humans occur nor whether the dose-effect relationship is linear or curvilinear. The central issue is whether there is merit in a continuing effort to reduce radiation exposures to patients no matter at what level. This should be determined by a careful balancing of potential risks against expected benefits. It is this element of risk-benefit analysis that is absent in Morgan's philosophy. A good example of the changing nature on the risk-benefit balance is that of the use of mass radiography programs to diagnose tuberculosis. Before the Second World War this disease was a terrible scourge of the poor who could ill-afford adequate medical care. The use of mass radiography programs have played a large part in the elimination of this disease

  11. Experience with qualification examinations of workers handling ionizing radiation sources

    International Nuclear Information System (INIS)

    Skokanova, K.

    1976-01-01

    The organization is described of examinations which have to be passed by supervising staff and workers using radioactive ionizing radiation sources. The requirements are listed of the examination in which these workers have to prove their professional knowledge and skills. The said examinations significantly contribute to the establishment of a system of safeguards at workplaces using ionizing radiation sources and may help economize operations at these workplaces

  12. Radiological Protection Experience with natural sources of radiation

    International Nuclear Information System (INIS)

    Quindos, L. S.; Fernandez, P. L.; Vinuela, J.; Arteche, J.; Sainz, G.; Gomez, J.; Matarranz

    2003-01-01

    During the last twenty five years the research Radon Group of the Medical Physics Unit of the University of Cantabria has been involved in projects concerning the measurement of natural radiation, in special that coming from radon gas. At this moment we have available for this field a lot of information in different formats, as paper, video and CD, interesting not only for public in general but also for professionals interested in the evaluation of doses coming from natural sources of radiation. (Author)

  13. Astrophysical radiative shocks: From modeling to laboratory experiments

    Czech Academy of Sciences Publication Activity Database

    Gonzales, N.; Stehlé, C.; Audit, E.; Busquet, M.; Rus, Bedřich; Thais, F.; Acef, O.; Barroso, P.; Bar-Shalom, A.; Bauduin, D.; Kozlová, Michaela; Lery, T.; Madouri, A.; Mocek, Tomáš; Polan, Jiří

    2006-01-01

    Roč. 24, - (2006), s. 535-540 ISSN 0263-0346 EU Projects: European Commission(XE) 506350 - LASERLAB-EUROPE; European Commission(XE) 5592 - JETSET Grant - others:CNRS(FR) PNPS Institutional research plan: CEZ:AV0Z10100523 Keywords : laboratory astrophysics * laser plasmas * radiative shock waves * radiative transfer Subject RIV: BH - Optics, Masers, Lasers Impact factor: 3.958, year: 2006

  14. Research on the NPP human factors engineering operating experience review

    International Nuclear Information System (INIS)

    Ren Xiangchen; Miao Hongxing; Ning Zhonghe

    2006-01-01

    This paper addresses the importance of the human factors engineering (HFE) for the design of nuclear power plant (NPP), especially for the design of human-machine interface in the NPP. It also summarizes the scope and content of the NPP HFE. The function, scope, content and process of the NPP human factors engineering operating experience review (OER) are mainly focused on, and significantly discussed. Finally, it briefly introduces the situation of the studies on the OER in China. (authors)

  15. An Experiment in Radiation Measurement Using the Depron Instrument

    Science.gov (United States)

    Benghin, Victor V.; Nechaev, Oleg Y.; Zolotarev, Ivan A.; Amelyushkin, Alexander M.; Petrov, Vasiliy L.; Panasyuk, Milhail I.; Yashin, Ivan V.

    2018-02-01

    Most of the radiation measurements have been made onboard spacecraft flying along orbits with an inclination of up to 51.6 degrees. Due to the prospect of manned missions at orbits with larger inclinations, it is advisable to conduct preliminary detailed dosimetry measurements at a high-inclination orbit; due to its polar orbit, the Lomonosov satellite provides good opportunities for such study. We chose a method of cosmic radiation dosimetry based on semiconductor detectors. This method is widely used onboard spacecraft, including full-time radiation monitoring onboard the International Space Station (ISS). It should be noted that not only did the charged particles contribute significantly in the dose equivalent, but also did the neutrons. Semiconductor detectors have low sensitivity to neutron radiation and are not sufficient for detecting the expected flux of neutrons. We add a thermal neutron counter to the proposed device in order to provide an opportunity for estimation of neutron flux variations along the satellite trajectory. Thus, the design of the instrument DEPRON (Dosimeter of Electrons, PROtons and Neutrons) was determined. DEPRON is intended for registration of the absorbed doses and linear energy transfer spectra for high-energy electrons, protons and nuclei of space radiation, as well as registration of thermal neutrons. The present paper provides a brief description of the DEPRON instrument. Its calibration results and the first mission results of background radiation measurements are also presented.

  16. Understanding Arts and Humanities Students' Experiences of Assessment and Feedback

    Science.gov (United States)

    Adams, Joelle; McNab, Nicole

    2013-01-01

    This article examines how undergraduate students on arts and humanities courses experience assessment and feedback. The research uses a detailed audit, a specially devised questionnaire (the Assessment Experience Questionnaire), and student focus group data, and the article examines results from 19 programmes, comparing those from "arts and…

  17. Numerical simulation of thermal behaviors of a clothed human body with evaluation of indoor solar radiation

    International Nuclear Information System (INIS)

    Mao, Aihua; Luo, Jie; Li, Yi

    2017-01-01

    Highlights: • Solar radiation evaluation is integrated with the thermal transfer in clothed humans. • Thermal models are developed for clothed humans exposed in indoor solar radiation. • The effect of indoor solar radiation on humans can be predicted in different situations in living. • The green solar energy can be efficiently utilized in the building development. - Abstract: Solar radiation is a valuable green energy, which is important in achieving a successful building design for thermal comfort in indoor environment. This paper considers solar radiation indoors into the transient thermal transfer models of a clothed human body and offers a new numerical method to analyze the dynamic thermal status of a clothed human body under different solar radiation incidences. The evaluation model of solar radiation indoors and a group of coupled thermal models of the clothed human body are developed and integrated. The simulation capacities of these integrated models are validated through a comparison between the predicted results and the experimental data in reference. After that, simulation cases are also conducted to show the influence of solar radiation on the thermal status of individual clothed body segments when the human body is staying indoors in different seasons. This numerical simulation method provides a useful tool to analyze the thermal status of clothed human body under different solar radiation incidences indoors and thus enables the architect to efficiently utilize the green solar energy in building development.

  18. Radiation protection officers in customs : an experience in Paraguay

    International Nuclear Information System (INIS)

    Oscar Bordon

    2008-01-01

    The September 11, 2001 events unleashed an offensive of the United States government to detect devices that could suppose a terrorist threat. One U.S. program entitled the Container Security Initiative affected all the customs in the world. All the countries desiring commerce with the USA must be signatory to the program; otherwise its products will not arrive to the U.S. ports. With that imposition Customs began to invest more in non-intrusive means of detection. The introduction of new equipment into the Customs environment forced the institution to enter a new area called radiation protection. The beginning was difficult due to the lack of knowledge concerning procedures in the ionizing radiation field. Not one legal regulation was known. Fortunately, the regulatory authority followed the purchase of the scanner and communicated the necessity of a license to operate and demanded that a qualified person in the radiation protection area be hired. Initially the main goal required the officer to obtain the license; however, this took some time because neither national nor international norms for scanners in Customs existed. At that time the recommendations of the regulatory authority were essential. Therefore, several procedures were adapted, thus reinforcing the necessity of specific rules for scanners in Customs. The support of the Customs director was essential. A department of radiation protection was created. Immediately a series of informative classes about radiation protection was administered producing changes in the minds of the employees, especially concerning the safety of working with ionizing radiation. This paper discusses the role of the radiation protection officer within Customs, the difficulties of this position, and the benefits that the collaboration of the officer can bring towards the construction of a safety culture in this institution. (author)

  19. Area radiation monitoring on ISS Increments 17 to 22 using PADLES in the Japanese Experiment Module Kibo

    International Nuclear Information System (INIS)

    Nagamatsu, A.; Murakami, K.; Kitajo, K.; Shimada, K.; Kumagai, H.; Tawara, H.

    2013-01-01

    The measurement of radiation environmental parameters in space is essential to support radiation risk assessments for astronauts and establish a benchmark for space radiation models for present and future human space activities. The Japan Aerospace Exploration Agency (JAXA) is performing a continuous area radiation monitoring experiment using the “PAssive Dosimeters for Lifescience Experiments in Space” (PADLES) system inside the Japanese Experiment Module Kibo on board the International Space Station (ISS). The PADLES dosimeter consists of thermoluminescent dosimeters (TLDs) and CR-39 plastic nuclear track detectors (PNTDs). JAXA has run the Area PADLES experiment since the Kibo module was attached to the ISS in June 2008, using 17 dosimeters in fixed locations on the Pressurized Module (PM) and the Experiment Logistics Module-Pressurized Section (ELM-PS) of Kibo, which are replaced every 6 months or every Increment, respectively. For three monitoring periods, known as Area PADLES experiment series no. 1 to no. 3, of 301, 180, and 232 days in June 2008 to April 2010 over ISS Increments 17 to 22, the average absorbed dose (dose equivalent) rates of 12 positions in the PM of Kibo were 319 ± 30 μGy/day (618 ± 102 μSv/day), 276 ± 30 μGy/day (608 ± 94 μSv/day), and 293 ± 33 μGy/day (588 ± 84 μSv/day), respectively. The radiation measurement in the ELM-PS was conducted in only Area PADLES experiment series no. 3 from August 2009 to April 2010 (232 days) over ISS Increments 21 to 22, the average absorbed dose (dose equivalent) rates of 5 positions was 297 ± 28 μGy/day (661 ± 65 μSv/day). The directional dependence of the radiation field was also investigated by installing PADLES dosimeters located in the zenith of ELM-PS of Kibo. -- Highlights: • This article shows the first results of dose measurement inside the Japanese Experiment Module Kibo with the PADLES system. • Generating spatial dose distribution data with the PADLES system are key

  20. Ultraviolet Radiation Induced Apoptosis in Human Skin In Vivo

    Energy Technology Data Exchange (ETDEWEB)

    Sheehan, J.M.; Young, A.R

    2000-07-01

    Sunburn cells, having many characteristics of apoptotic cells, appear in human skin after exposure to UVB. Time-courses and dose responses for solar simulated radiation (SSR)-induced sunburn cells in human volunteers of skin type II have been determined. For the time-course, two groups of volunteers were exposed to two minimal erythema doses (MED) of SSR. Punch biopsies were obtained from Group 1 immediately, 3, 6, 12, 18 and 24 h after SSR exposure and Group 2 were biopsied immediately, 18, 24, 36, 48 and 72 h after exposure. For the dose-response (Group 3), biopsies were taken 24 h after SSR exposure to 0, 0.25, 0.5, 1, 2 and 3 MED. Sections were stained with H and E and also using TUNEL and analysed by light microscopy. Results show a dose-dependent appearance of SBC after SSR exposure. The time point for maximum SBC counts with both H and E staining and TUNEL staining lie between 24 and 36 h. (author)

  1. Ultraviolet Radiation Induced Apoptosis in Human Skin In Vivo

    International Nuclear Information System (INIS)

    Sheehan, J.M.; Young, A.R.

    2000-01-01

    Sunburn cells, having many characteristics of apoptotic cells, appear in human skin after exposure to UVB. Time-courses and dose responses for solar simulated radiation (SSR)-induced sunburn cells in human volunteers of skin type II have been determined. For the time-course, two groups of volunteers were exposed to two minimal erythema doses (MED) of SSR. Punch biopsies were obtained from Group 1 immediately, 3, 6, 12, 18 and 24 h after SSR exposure and Group 2 were biopsied immediately, 18, 24, 36, 48 and 72 h after exposure. For the dose-response (Group 3), biopsies were taken 24 h after SSR exposure to 0, 0.25, 0.5, 1, 2 and 3 MED. Sections were stained with H and E and also using TUNEL and analysed by light microscopy. Results show a dose-dependent appearance of SBC after SSR exposure. The time point for maximum SBC counts with both H and E staining and TUNEL staining lie between 24 and 36 h. (author)

  2. Statistical physics of human beings in games: Controlled experiments

    International Nuclear Information System (INIS)

    Liang Yuan; Huang Ji-Ping

    2014-01-01

    It is important to know whether the laws or phenomena in statistical physics for natural systems with non-adaptive agents still hold for social human systems with adaptive agents, because this implies whether it is possible to study or understand social human systems by using statistical physics originating from natural systems. For this purpose, we review the role of human adaptability in four kinds of specific human behaviors, namely, normal behavior, herd behavior, contrarian behavior, and hedge behavior. The approach is based on controlled experiments in the framework of market-directed resource-allocation games. The role of the controlled experiments could be at least two-fold: adopting the real human decision-making process so that the system under consideration could reflect the performance of genuine human beings; making it possible to obtain macroscopic physical properties of a human system by tuning a particular factor of the system, thus directly revealing cause and effect. As a result, both computer simulations and theoretical analyses help to show a few counterparts of some laws or phenomena in statistical physics for social human systems: two-phase phenomena or phase transitions, entropy-related phenomena, and a non-equilibrium steady state. This review highlights the role of human adaptability in these counterparts, and makes it possible to study or understand some particular social human systems by means of statistical physics coming from natural systems. (topical review - statistical physics and complex systems)

  3. Statistical physics of human beings in games: Controlled experiments

    Science.gov (United States)

    Liang, Yuan; Huang, Ji-Ping

    2014-07-01

    It is important to know whether the laws or phenomena in statistical physics for natural systems with non-adaptive agents still hold for social human systems with adaptive agents, because this implies whether it is possible to study or understand social human systems by using statistical physics originating from natural systems. For this purpose, we review the role of human adaptability in four kinds of specific human behaviors, namely, normal behavior, herd behavior, contrarian behavior, and hedge behavior. The approach is based on controlled experiments in the framework of market-directed resource-allocation games. The role of the controlled experiments could be at least two-fold: adopting the real human decision-making process so that the system under consideration could reflect the performance of genuine human beings; making it possible to obtain macroscopic physical properties of a human system by tuning a particular factor of the system, thus directly revealing cause and effect. As a result, both computer simulations and theoretical analyses help to show a few counterparts of some laws or phenomena in statistical physics for social human systems: two-phase phenomena or phase transitions, entropy-related phenomena, and a non-equilibrium steady state. This review highlights the role of human adaptability in these counterparts, and makes it possible to study or understand some particular social human systems by means of statistical physics coming from natural systems.

  4. Human radiation studies: Remembering the early years: Oral history of health physicist Carl C. Gamertsfelder, Ph.D., conducted January 19, 1995

    International Nuclear Information System (INIS)

    Fisher, T.; Yuffee, M.

    1995-09-01

    This report is a transcript of an interview of Dr. Carl C. Gamertsfelder by representatives of the DOE Office of Human Radiation Experiments. Dr. Gamertsfelder was selected for this interview because of experiences with contractors to the Manhattan Project and to the Atomic Energy Commission. Following a brief biographical sketch, Dr. Gamertsfelder related his remembrances of University of Chicago, of Oak Ridge, and of Hanford during world war II. He also describes his postwar experiences at Hanford, with the Nuclear- Powered Aircraft Program, and with the Apollo Project. Some subjects discussed include the Green Run, radiation accidents, radiation monitoring, Health Physics, and the storage tanks at Hanford

  5. Human projected area factors for detailed direct and diffuse solar radiation analysis

    DEFF Research Database (Denmark)

    Kubaha, K.; Fiala, D.; Toftum, Jørn

    2004-01-01

    Projected area factors for individual segments of the standing and sedentary human body were modelled for both direct and diffuse solar radiation using detailed 3D geometry and radiation models. The local projected area factors with respect to direct short-wave radiation are a function of the solar...

  6. Time-resolved experiments in the frequency domain using synchrotron radiation (invited)

    Science.gov (United States)

    De Stasio, Gelsomina; Giusti, A. M.; Parasassi, T.; Ravagnan, G.; Sapora, O.

    1992-01-01

    PLASTIQUE is the only synchrotron radiation beam line in the world that performs time-resolved fluorescence experiments in frequency domain. These experiments are extremely valuable sources of information on the structure and the dynamics of molecules. This technique measures fluorescence lifetimes with picosecond resolution in the near UV spectral range. Such accurate measurements are rendered possible by taking phase and modulation data, and by the advantages of the cross-correlation technique. A successful experiment demonstrated the radiation damage induced by low doses of radiation on rabbit blood cell membranes.

  7. Experience in Strengthening Cooperation Between Radiation Safety Regulators in Europe

    International Nuclear Information System (INIS)

    Magnusson, S.

    2016-01-01

    HERCA is a voluntary association in which the Heads of Radiation Protection Authorities in Europe work together in order to develop common regulatory approaches in terms of practical implementation. HERCA addresses topics generally covered by provisions of the EURATOM Treaty and its work program is based on significant regulatory issues of common interest. HERCA was established in 2007 and brings together 51 radiation protection Authorities from 31 European countries. The current HERCA work program focuses on Medical and Veterinary Applications, Emergency Preparedness and Response, Non-Medical Sources and Practices, Radon and Euratom BSS Transposition as well as Education and Training.

  8. Human radiation studies: Remembering the early years: Oral history of radiologist Henry I. Kohn, M.D., Ph.D., conducted September 13, 1994

    International Nuclear Information System (INIS)

    1995-06-01

    This report is a transcript of an interview of Dr. Henry I. Kohn by representatives of the US DOE Office of Human Radiation Experiments. Dr. Kohn was selected for this interview because of the positions he held at Oak Ridge National Laboratory, University of California at San Francisco, and Harvard Medical School. Dr. Kohn discussed his remembrances of his experiences in blood chemistry of animals and patients exposed to radiation, and his remembrances of several radiobiologists

  9. Medical physics staffing for radiation oncology: a decade of experience in Ontario, Canada

    Science.gov (United States)

    Battista, Jerry J.; Patterson, Michael S.; Beaulieu, Luc; Sharpe, Michael B.; Schreiner, L. John; MacPherson, Miller S.; Van Dyk, Jacob

    2012-01-01

    The January 2010 articles in The New York Times generated intense focus on patient safety in radiation treatment, with physics staffing identified frequently as a critical factor for consistent quality assurance. The purpose of this work is to review our experience with medical physics staffing, and to propose a transparent and flexible staffing algorithm for general use. Guided by documented times required per routine procedure, we have developed a robust algorithm to estimate physics staffing needs according to center‐specific workload for medical physicists and associated support staff, in a manner we believe is adaptable to an evolving radiotherapy practice. We calculate requirements for each staffing type based on caseload, equipment inventory, quality assurance, educational programs, and administration. Average per‐case staffing ratios were also determined for larger‐scale human resource planning and used to model staffing needs for Ontario, Canada over the next 10 years. The workload specific algorithm was tested through a survey of Canadian cancer centers. For center‐specific human resource planning, we propose a grid of coefficients addressing specific workload factors for each staff group. For larger scale forecasting of human resource requirements, values of 260, 700, 300, 600, 1200, and 2000 treated cases per full‐time equivalent (FTE) were determined for medical physicists, physics assistants, dosimetrists, electronics technologists, mechanical technologists, and information technology specialists, respectively. PACS numbers: 87.55.N‐, 87.55.Qr PMID:22231223

  10. Radiation protection safety in Uganda -- Experience and prospects of the National Radiation Protection Service

    International Nuclear Information System (INIS)

    Kisolo, A.

    2001-01-01

    The Uganda National Radiation Protection Service (NRPS) is a technical body under the Atomic Energy Control Board, established by Law - the Atomic Energy Decree of 1972, Decree No. 12, to oversee and enforce safety of radiation sources, practices and workers; and to protect the patients, members of the public and the environment from the dangers of ionizing radiation and radioactive wastes. The Ionizing Radiation Regulations (Standards) - Statutory Instruments Supplement No. 21 of 1996 -- back up the Law. The Law requires all users, importers and operators of radiation sources and radioactive materials to notify the NRPS for registration and licensing. The NRPS is responsible for licensing and for the regulatory enforcement of compliance to the requirements for the safety of radiation sources and practices. There are about 200 diagnostic X-ray units, two radiotherapy centres, one nuclear medicine unit, several neutron probes, about three level gauges and two non-destructive testing sources and a number of small sealed sources in teaching and research institutions. About 50% of these sources have been entered in our inventory using the RAIS software provided by the IAEA. There are about 500 radiation workers and 250 underground miners. The NRPS covers about 50% of the radiation workers. It is planned that by June 2001, all occupational workers will be monitored, bringing coverage to 100%. The Government of Uganda is making the necessary legal, administrative and technical arrangements aimed at establishing the National Radiation Protection Commission as an autonomous regulatory authority. The Atomic Energy Decree of 1972 and Regulations of 1996 are being revised to provide for the National Radiation Protection Commission and to make it comply with the requirements of the International Basic Safety Standards Safety Series No. 115. (author)

  11. Experiences in the monitoring of radiation workers in industry and hospitals in the Philippines

    International Nuclear Information System (INIS)

    Mateo, A.J.

    1976-08-01

    The task of monitoring of radiation doses among radiation workers employed either in industry and hospitals in the Philippines is presently being undertaken by the Philippine Atomic Energy Commission. These radiation monitoring devices cover not only radioactive materials or sources but also x-ray machines. The most common dosimetry used is the film badge. This paper presents some of the experiences gained in the use of the film badge and other dosimeters

  12. Mathematical human phantoms and their application to radiation protection

    International Nuclear Information System (INIS)

    Yamaguchi, Yasuhiro

    1998-01-01

    This review described the characteristics of mathematical phantoms, their history over 30 years and their application. Mathematical phantoms are classified into two models of formula and voxel types. In the former, human body and organs are described by 2- and/or 3-D mathematical formula and can be seen as a combination of solid bodies like spheres, cubes and ovals. The phantom is composed from three tissue components (bone, lung and soft tissue) and made on data on Reference Man in ICRP Publ. 23. The latter voxel (volume pixel) phantom consists from a number of small cubes based on CT and MRI images of a certain man. For instance, the phantom CHILD, 1.54 x 1.54 x 8.00 mm 3 in size, is based on a 7-year old child, which consisting from about one million voxels. The mathematical phantom was first made in Oak Ridge National Laboratory in the middle of the nineteen-sixties, which have undergone various improvements to reach MIRD-5 phantom. Thereafter, many similitude phantoms have been made as a variation of MIRD-5, depending on age and sex (e.g., ADAM and EVA). Voxel phantom was made in the middle of nineteen-eighties and have undergone improvements which are continued even currently in Japan, U.S. etc. The mathematical phantoms are used for calculation of radiation transport program by Monte Carlo method in the field of radiation protection. Also in the field of medicine, the phantom is used for calculation of internal and external exposure doses, of correction constants of externally measuring instruments, of doses for neutron capture therapy and of A-bomb exposure doses in Hiroshima and Nagasaki for reevaluation. Recently, the development of phantom is in the current from formula phantom to voxel one due to the purpose of precision and standardization. (K.H.)

  13. Human radiation studies: Remembering the early years. Oral history of biophysicist Cornelius A. Tobias, Ph.D., January 16, 1995

    International Nuclear Information System (INIS)

    1995-07-01

    Dr. Cornelius A. Tobias was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE). He was chosen for this interview because of his extensive biophysics and medical physics research activities while he was employed by the University of California, Berkeley and San Francisco and at the Donner Laboratory. He discusses his involvement in wartime studies of effects of high altitude on aviators, carbon monoxide with radioactive tracers, blood studies with radioactive iron, human use committees, heavy-ion research with the Bevatron, boron isotope research, classified research involving human subjects, heavy-particle radiography, heavy- particle beams and medical research, and pituitary irradiation studies,

  14. Human radiation studies: Remembering the early years. Oral history of biophysicist Cornelius A. Tobias, Ph.D., January 16, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    Dr. Cornelius A. Tobias was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE). He was chosen for this interview because of his extensive biophysics and medical physics research activities while he was employed by the University of California, Berkeley and San Francisco and at the Donner Laboratory. He discusses his involvement in wartime studies of effects of high altitude on aviators, carbon monoxide with radioactive tracers, blood studies with radioactive iron, human use committees, heavy-ion research with the Bevatron, boron isotope research, classified research involving human subjects, heavy-particle radiography, heavy- particle beams and medical research, and pituitary irradiation studies,.

  15. A transition radiation tracker (TRT) for the Atlas experiment

    International Nuclear Information System (INIS)

    Fuchs, W.

    1995-05-01

    The LHC (Large Hadron Collider) foresees two general purpose detectors, CMS and ATLAS. The inner ATLAS detector will make use of a Transition Radiation Tracker (TRT), which consists of a barrel TRT and a forward TRT. The TRT will provide additional rejection power in order to reduce the jet background to less than 10 % of the inclusive isolated electron signal. Transition Radiation (TR) is generated by charged particles when they cross an interface of changing dielectric behaviour (radiator). The intensity of TR produced is proportional to the γ-factor (γ=E/mc 2 ). A short introduction of TR theory is followed by optimization studies of the radiator and the working gas mixture. TR is detected by gas proportional counters (straws). The electrical and mechanical characteristics of the straws were studied. Furthermore, the straw's operation at the presence of the 2 T magnetic field was investigated. Any signal corresponds to a heat load which has to be cooled in order to provide stable conditions. A cooling system is presented. The induced signal exhibits a long lasting component (ion tail). This ion tail tends to influence signals which are closely spaced in time. A filter was designed which suppresses the ion tail (pole/zero network). The physics performance of some prototypes was studied, in particular the hadron rejection and the tracking capability. A full-scale prototype (9600 channels) was designed and manufactured. A summary of the machinery and tooling involved is presented. (author)

  16. Hypofractionated stereotactic radiation therapy for recurrent glioblastoma: single institutional experience

    International Nuclear Information System (INIS)

    Ciammella, Patrizia; Podgornii, Ala; Galeandro, Maria; D’Abbiero, Nunziata; Pisanello, Anna; Botti, Andrea; Cagni, Elisabetta; Iori, Mauro; Iotti, Cinzia

    2013-01-01

    Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Tumor control and survival have improved with the use of radiotherapy (RT) plus concomitant and adjuvant chemotherapy, but the prognosis remain poor. In most cases the recurrence occurs within 7–9 months after primary treatment. Currently, many approaches are available for the salvage treatment of patients with recurrent GBM, including resection, re-irradiation or systemic agents, but no standard of care exists. We analysed a cohort of patients with recurrent GBM treated with frame-less hypofractionated stereotactic radiation therapy with a total dose of 25 Gy in 5 fractions. Of 91 consecutive patients with newly diagnosed GBM treated between 2007 and 2012 with conventional adjuvant chemo-radiation therapy, 15 underwent salvage RT at recurrence. The median time interval between primary RT and salvage RT was 10.8 months (range, 6–54 months). Overall, patients undergoing salvage RT showed a longer survival, with a median survival of 33 vs. 9.9 months (p= 0.00149). Median overall survival (OS) from salvage RT was 9.5 months. No patients demonstrated clinically significant acute morbidity, and all patients were able to complete the prescribed radiation therapy without interruption. Our results suggest that hypofractionated stereotactic radiation therapy is effective and safe in recurrent GBM. However, until prospective randomized trials will confirm these results, the decision for salvage treatment should remain individual and based on a multidisciplinary evaluation of each patient

  17. Human Research Program Space Radiation Standing Review Panel (SRP)

    Science.gov (United States)

    Woloschak, Gayle; Steinberg-Wright, S.; Coleman, Norman; Grdina, David; Hill, Colin; Iliakis, George; Metting, Noelle; Meyers, Christina

    2010-01-01

    The Space Radiation Standing Review Panel (SRP) met at the NASA Johnson Space Center (JSC) on December 9-11, 2009 to discuss the areas of current and future research targeted by the Space Radiation Program Element (SRPE) of the Human Research Program (HRP). Using evidence-based knowledge as a background for identified risks to astronaut health and performance, NASA had identified gaps in knowledge to address those risks. Ongoing and proposed tasks were presented to address the gaps. The charge to the Space Radiation SRP was to review the gaps, evaluate whether the tasks addressed these gaps and to make recommendations to NASA s HRP Science Management Office regarding the SRP's review. The SRP was requested to evaluate the practicality of the proposed efforts in light of the demands placed on the HRP. Several presentations were made to the SRP during the site visit and the SRP spent sufficient time to address the SRP charge. The SRP made a final debriefing to the HRP Program Scientist, Dr. John B. Charles, on December 11, 2009. The SRP noted that current SRPE strategy is properly science-based and views this as the best assurance of the likelihood that answers to the questions posed as gaps in knowledge can be found, that the uncertainty in risk estimates can be reduced, and that a solid, cost-effective approach to risk reduction solutions is being developed. The current approach of the SRPE, based on the use of carefully focused research solicitations, requiring thorough peer-review and approaches demonstrated to be on the path to answering the NASA strategic questions, addressed to a broad extramural community of qualified scientists, optimally positioned to take advantage of serendipitous discoveries and to leverage scientific advances made elsewhere, is sound and appropriate. The SRP viewed with concern statements by HRP implying that the only science legitimately deserving support should be "applied" or, in some instances that the very term "research" might be

  18. Effect of radiation combined with hyperthermia on human prostatic carcinoma cell lines in culture

    International Nuclear Information System (INIS)

    Kaver, I.; Ware, J.L.; Wilson, J.D.; Koontz, W.W. Jr.

    1991-01-01

    The effect of radiation combined with heat on three human prostatic carcinoma cell lines growing in vitro was investigated. Cells were exposed to different radiation doses followed by heat treatment at 43 degrees C for one hour. Heat treatment, given ten minutes after radiation, significantly enhanced the radiation response of all the cell lines studied. The combined effect of radiation and heat produced greater cytotoxicity than predicted from the additive effects of the two individual treatment modalities alone. These results indicate that a combined treatment regimen of radiation plus hyperthermia (43 degrees, 1 hr) might be an important tool in maintaining a better local control of prostatic cancer

  19. Earth Radiation Budget Experiment (ERBE) Data Sets for Global Environment and Climate Change Studies

    Science.gov (United States)

    Bess, T. Dale; Carlson, Ann B.; Denn, Fredrick M.

    1997-01-01

    For a number of years there has been considerable interest in the earth's radiation budget (ERB) or energy balance, and entails making the best measurements possible of absorbed solar radiation, reflected shortwave radiation (RSW), thermal outgoing longwave radiation (OLR), and net radiation. ERB data are fundamental to the development of realistic climate models and studying natural and anthropogenic perturbations of the climate. Much of the interest and investigations in the earth's energy balance predated the age of earth-orbiting satellites (Hunt et al., 1986). Beginning in the mid 1960's earth-orbiting satellites began to play an important role in making measurements of the earth's radiation flux although much effort had gone into measuring ERB parameters prior to 1960 (House et al., 1986). Beginning in 1974 and extending until the present time, three different satellite experiments (not all operating at the same time) have been making radiation budget measurements almost continually in time. Two of the experiments were totally dedicated to making radiation budget measurements of the earth, and the other experiment flown on NOAA sun-synchronous AVHRR weather satellites produced radiation budget parameters as a by-product. The heat budget data from the AVHRR satellites began collecting data in June 1974 and have operated almost continuously for 23 years producing valuable data for long term climate monitoring.

  20. Planar radiative shock experiments and their comparison to simulations

    International Nuclear Information System (INIS)

    Reighard, A. B.; Drake, R. P.; Mucino, J. E.; Knauer, J. P.; Busquet, M.

    2007-01-01

    Recent experiments have obtained radiographic data from shock waves driven at >100 km/s in xenon gas, and Thomson scattering data from similar experiments using argon gas. Presented here is a review of these experiments, followed by an outline of the discrepancies between the data and the results of one-dimensional simulations. Simulations using procedures that work well for similar but nonradiative experiments show inconsistencies between the measured position of the interface of the beryllium and xenon and the calculated position for these experiments. Sources of the discrepancy are explored

  1. Adjuvant radiation therapy for pancreatic cancer: a 15-year experience

    International Nuclear Information System (INIS)

    Dobelbower, Ralph R.; Merrick, Hollis W.; Khuder, Sadik; Battle, Joyce A.; Herron, Lisa M.; Pawlicki, Todd

    1997-01-01

    Purpose: A retrospective analysis to determine differences in survival of patients with pancreatic aden carcinoma treated by radical surgery with and without adjuvant radiation therapy. Methods and Materials: Between 1980 and 1995, 249 patients with pancreatic tumors were identified at the Medical College of Ohio. Forty-four of these patients underwent radical surgical procedures with curative intent. These patients were divided into four groups according to treatment: surgery alone (n = 14), surgery plus intraoperative radiation therapy (IORT) (n = 6), surgery plus external beam radiation therapy (EBRT) (n = 14), or surgery plus both IORT and EBRT (n = 10). Outcome and survival were analyzed among the four groups. Results: The median survival time of patients treated with radical surgery alone was 6.5 months. The median survival time for the surgery plus IORT group was 9 months; however, 33.3% (two of six) of these patients survived longer than 5 years. This survival pattern was borderline significantly better than that for the surgery alone group (p = 0.0765). The surgery plus EBRT and the surgery plus IORT and EBRT groups had median survival times of 14.5 and 17.5 months, respectively. These were significantly better than that of the surgery alone group (p = 0.0004 and p = 0.0002, respectively). The addition of radiation therapy did not affect the treatment complication rate. Conclusion: The survival of patients who were treated with radical surgery alone was significantly poorer than that of patients who received adjuvant radiation therapy. These results are consistent with other studies in the literature. Patients treated with all three modalities (surgery, IORT, and EBRT) displayed the best median survival time

  2. Comparison of gamma radiation - induced effects in two human prostate cancer cells

    International Nuclear Information System (INIS)

    Vucic, V.; Adzic, M.; Ruzdijic, S.; Radojcic, M.B. . E-mail address of corresponding author: vesnav@vin.bg.ac.yu; Vucic, V.)

    2005-01-01

    In this study, the effects of gamma radiation on two hormone refractory human prostate cancer cell lines, DU 145 and PC-3, were followed. It was shown that gamma radiation induced significant inhibition of cell proliferation and viability in dose dependent manner. Antiproliferative effects of radiation were similar in both cell lines, and more pronounced than cytotoxic effects. In addition to that, PC-3 cell line was more resistant to radiation -induced cytotoxicity. (author)

  3. The "Chocolate Experiment"--A Demonstration of Radiation Absorption by Different Colored Surfaces

    Science.gov (United States)

    Fung, Dennis

    2015-01-01

    In the typical "cookbook" experiment comparing the radiation absorption rates of different colored surfaces, students' hands are commonly used as a measurement instrument to demonstrate that dull black and silvery surfaces are good and poor absorbers of radiation, respectively. However, college students are often skeptical about using…

  4. Theory for beam-plasma millimeter-wave radiation source experiments

    International Nuclear Information System (INIS)

    Rosenberg, M.; Krall, N.A.

    1989-01-01

    This paper reports on theoretical studies for millimeter-wave plasma source experiments. In the device, millimeter-wave radiation is generated in a plasma-filled waveguide driven by counter-streaming electron beams. The beams excite electron plasma waves which couple to produce radiation at twice the plasma frequency. Physics topics relevant to the high electron beam current regime are discussed

  5. Radiation therapists' perceptions of the minimum level of experience required to perform portal image analysis

    International Nuclear Information System (INIS)

    Rybovic, Michala; Halkett, Georgia K.; Banati, Richard B.; Cox, Jennifer

    2008-01-01

    Background and purpose: Our aim was to explore radiation therapists' views on the level of experience necessary to undertake portal image analysis and clinical decision making. Materials and methods: A questionnaire was developed to determine the availability of portal imaging equipment in Australia and New Zealand. We analysed radiation therapists' responses to a specific question regarding their opinion on the minimum level of experience required for health professionals to analyse portal images. We used grounded theory and a constant comparative method of data analysis to derive the main themes. Results: Forty-six radiation oncology facilities were represented in our survey, with 40 questionnaires being returned (87%). Thirty-seven radiation therapists answered our free-text question. Radiation therapists indicated three main themes which they felt were important in determining the minimum level of experience: 'gaining on-the-job experience', 'receiving training' and 'working as a team'. Conclusions: Radiation therapists indicated that competence in portal image review occurs via various learning mechanisms. Further research is warranted to determine perspectives of other health professionals, such as radiation oncologists, on portal image review becoming part of radiation therapists' extended role. Suitable training programs and steps for implementation should be developed to facilitate this endeavour

  6. The background of external γ radiation in the proportional counters in SAGE experiment

    International Nuclear Information System (INIS)

    Gavrin, V.N.; Gorbachev, V.V.

    2003-01-01

    The influence of external γ radiation on the process of 71 Ge-decay counting in proportional counters in SAGE experiment of solar neutrino flux measurement is examined. One determines the systematic error of SAGE result, connected with radon decays inside the air volume surrounding the counters, and the background counting rate of proportional counters from γ radiation of passive and active shield [ru

  7. Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts

    DEFF Research Database (Denmark)

    Rødningen, Olaug Kristin; Overgaard, Jens; Alsner, Jan

    2005-01-01

    cell lines after various ionizing radiation (IR) schemes in order to provide information on potential targets for prevention and to suggest candidate genes for SNP association studies aimed at predicting individual risk of radiation-induced morbidity. PATIENTS AND METHODS: Thirty different human......BACKGROUND AND PURPOSE: Transcriptional profiling of fibroblasts derived from breast cancer patients might improve our understanding of subcutaneous radiation-induced fibrosis. The aim of this study was to get a comprehensive overview of the changes in gene expression in subcutaneous fibroblast...... fibroblast cell lines were included in the study, and two different radiation schemes; single dose experiments with 3.5 Gy or fractionated with 3 x 3.5 Gy. Expression analyses were performed on unexposed and exposed cells after different time points. The IR response was analyzed using the statistical method...

  8. Radiation effects on the human organs, app. A

    International Nuclear Information System (INIS)

    Anon.

    1976-01-01

    The appendix is subdivided into eleven chapters dealing with radiation effcts on organisms and comprising the following subjects: biological effects of ionizing radiations (dose, LET, RBE, formation of radicals, age and sex, cell types, biological repair), recommendations and protective measures for somatic risks, genetic risks, experimental models and dose-effect relationships, and internal radiation. The groups conclusions are given

  9. Visual assessment of the radiation distribution in the ISS Lab module: visualization in the human body

    Science.gov (United States)

    Saganti, P. B.; Zapp, E. N.; Wilson, J. W.; Cucinotta, F. A.

    2001-01-01

    The US Lab module of the International Space Station (ISS) is a primary working area where the crewmembers are expected to spend majority of their time. Because of the directionality of radiation fields caused by the Earth shadow, trapped radiation pitch angle distribution, and inherent variations in the ISS shielding, a model is needed to account for these local variations in the radiation distribution. We present the calculated radiation dose (rem/yr) values for over 3,000 different points in the working area of the Lab module and estimated radiation dose values for over 25,000 different points in the human body for a given ambient radiation environment. These estimated radiation dose values are presented in a three dimensional animated interactive visualization format. Such interactive animated visualization of the radiation distribution can be generated in near real-time to track changes in the radiation environment during the orbit precession of the ISS.

  10. Effects of environmental radiation of Kori nuclear power plant on the human population

    International Nuclear Information System (INIS)

    Kim, Y.J.

    1979-01-01

    In order to clarify and protect the effects of environmental radiation according to the operation of Kori nuclear power plant on human population, the base line survey for the human monitoring, the fauna of land nocturnal insects, and the karyotypes of amphibian species which have been living around the power plant site were carried out. ''Kilchunri'' population which took for the human monitoring lie within a 2km distance from power plant site. Human monitoring, house and food characteristics, individual experience of X-ray exposures, human chromosome analysis and fauna of nocturnal land insects were surveyed and expressed in numerical tables. Chromosome number obtained from the amphibia which were collected around the power plant area was as follows; Kaloula borealis 2N=30, Rana amurensis 2N=26, Rana dybouskii 2N=24, Rana rugosa 2N=26, Rana migromaculata 2N=26, Rana plancyi 2N=26, Bombina orientalis 2N=24, Hyla arborea 2N=24, Bufo stejnegeri 2N=22, and Bufo bufo 2N=22. (author)

  11. Effects of radiation on the human gastrointestinal tract

    International Nuclear Information System (INIS)

    Novak, J.M.; Collins, J.T.; Donowitz, M.; Farman, J.; Sheahan, D.G.; Spiro, H.M.

    1979-01-01

    Radiation therapy directed at the abdomen may damage the digestive tract, the type and extent of injury depending on the dose of the radiation and the radiation sensitivity of the gut. Characteristic early changes are manifest in the mucosa of the gut: for later ulceration, changes in the collagen tissues and particularly in the vascular channels occur. This paper describes and characterizes injuries to the esophagus, stomach, small intestine and colon. It emphasizes the importance of recognizing radiation-induced damage to the gut which may occur early or late after radiation

  12. Science experiments via telepresence at a synchrotron radiation source facility

    International Nuclear Information System (INIS)

    Warren, J. E.; Diakun, G.; Bushnell-Wye, G.; Fisher, S.; Thalal, A.; Helliwell, M.; Helliwell, J. R.

    2008-01-01

    The application of a turnkey communication system for telepresence at station 9.8 of the Synchrotron Radiation Source, Daresbury, is described and demonstrated, including its use for inter-continental classroom instruction and user training. Station 9.8 is one of the most oversubscribed and high-throughput stations at the Synchrotron Radiation Source, Daresbury, whereby awarded experimental time is limited, data collections last normally no longer than an hour, user changeover is normally every 24 h, and familiarity with the station systems can be low. Therefore time lost owing to technical failures on the station has a dramatic impact on productivity. To provide 24 h support, the application of a turnkey communication system has been implemented, and is described along with additional applications including its use for inter-continental classroom instruction, user training and remote participation

  13. Molecular biology methods in assessing radiation-induced hereditary risks in humans

    International Nuclear Information System (INIS)

    Kiuru, A.

    2004-12-01

    Effort to predict the genetic consequences for humans of exposure to ionising radiation has been one of the most important issues of human genetics over the past 60 years. To date, there has been little experimental knowledge on the genetic risks of human exposure to ionising radiation. Radiation-induced deleterious hereditary effects have not been detected in human populations - not even among the offspring of atomic bomb survivors in Hiroshima and Nagasaki. This does not mean deleterious hereditary effects do not exist in humans, but rather that they are small and/or difficult to detect because the normal incidence of inherited abnormalities is quite high in the human population. Thus, assessment of radiation-induced hereditary risks in humans has been based on the common knowledge of human heredity and on animal experiments. However, recent data have suggested that hyper-variable tandem repeat minisatellite loci provide a useful and sensitive experimental approach for monitoring radiation-induced germline mutations in humans. In order to investigate the feasibility of the minisatellite mutation screening system in assessing radiation-induced hereditary risks in humans, we examined the amount of hereditary minisatellite mutations among the offspring of Estonian Chernobyl cleanup workers. The men studied received a median radiation dose of 109 mSv while working on the cleanup activities after the Chernobyl accident. We compared the minisatellite mutation rates of 155 children born to 147 Estonian Chernobyl cleanup workers after the accident to those of their 148 siblings born prior to it. In addition, 44 Estonian families, where the father had not been exposed to radiation, composed an additional control group. In all of these families, the paternity of the children was ascertained by using 5 minisatellite loci (APOB, HRAS, MCOB19, MCT118, and YNZ-22) in PCR-based analyses. Other 8 minisatellite loci (B6.7, CEB1, CEB15, CEB25, CEB36, MS1, MS31, and MS32) were used

  14. Micro-irradiation experiments in MOS transistors using synchrotron radiation

    International Nuclear Information System (INIS)

    Autran, J.L.; Masson, P.; Raynaud, C.; Freud, N.; Riekel, C.

    1999-01-01

    Spatially-resolved total-dose degradation has been performed in MOS transistors by focusing x-ray synchrotron radiation on the gate electrode with micrometer resolution. The influence of the resulting permanent degradation on device electrical properties has been analyzed using current-voltage and charge pumping measurements, in concert with optical characterization (hot-carrier luminescence) and one-dimensional device simulation. (authors)

  15. Experiment and research on materials irradiated by plasma radiation

    International Nuclear Information System (INIS)

    Hong Wenyu; Yao Lianghua; Tang Sujun; Chang Shufen; Li Guodong

    1992-08-01

    The TiC and SiC coating on the graphite substrate and wall carbonization were studied by plasma radiation in HL-1 tokamak. Samples were analysed with AES (auger electron spectroscopy), SEM (scanning electron microscopy), XPS (X-ray photoelectron spectroscopy) and XDS (X-ray diffraction spectroscopy). The results show that the TiC and SiC materials coated on limiter and wall and wall carbonization can reduce the metal and oxygen impurities and improve the plasma merit

  16. Experience in the development and practical use of working control levels for radiation safety

    International Nuclear Information System (INIS)

    Epishin, A.V.

    1981-01-01

    The experience of development and practical use of working control levels (WCL) of radiation safety in the Gorky region, is discussed. WCL are introduced by ''Radiation Safety Guides'' (RSG-76) and have great practical importance. Regional control levels of radiation safety are determined for certain types of operations implying radioactive hazard and differentiated according to the types of sources applied and types of operation. Dose rates, radioactive contamination of operating surfaces, skin, air and waste water are subject to normalization. Limits of individual radiation doses specified according to operation categories are included. 10 tables of regional WCL indices are developed [ru

  17. First Results from the Online Radiation Dose Monitoring System in ATLAS experiment

    CERN Document Server

    Mandić, I; The ATLAS collaboration; Deliyergiyev, M; Gorišek, A; Kramberger, G; Mikuž, M; Franz, S; Hartert, J; Dawson, I; Miyagawa, P S; Nicolas, L

    2011-01-01

    High radiation doses which will accumulate in components of ATLAS experiment during data taking will cause damage to detectors and readout electronics. It is therefore important to continuously monitor the doses to estimate the level of degradation caused by radiation. Online radiation monitoring system measures ionizing dose in SiO2 and fluences of 1-MeV(Si) equivalent neutrons and thermal neutrons at several locations in ATLAS detector. In this paper measurements collected during two years of ATLAS data taking are presented and compared to predictions from radiation background simulations.

  18. Training programmes and experiences of medical emergency preparedness for radiation accident in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki-Yasumoto, M

    1982-01-01

    Our policy of training programmes for medical radiation emergency preparedness is described. We found it is necessary to have two approaches to the training of relevant personnel. The first approach was to conduct adequate basic training of nurses and health physics personnel in large nuclear installations for medical radiation emergency preparedness. We found it was necessary to have courses for basic knowledge of nuclear radiation and industrial activities, radiation monitoring procedures, radiation injuries, human counters and wound monitors, first aid practices, and radiation medical emergency procedures including practices. The second approach was to make a simple and introductory training program on the subject using lectures and visual presentations in the vicinity of big nuclear installations for personnel relating to the nuclear industrial activities and for concerned local personnel, including medical doctors and nurses. These two training courses and approaches were planned and have been conducted. 2 refs. (DT)

  19. Modeling and design of radiative hydrodynamic experiments with X-ray Thomson Scattering measurements on NIF

    Science.gov (United States)

    Ma, K. H.; Lefevre, H. J.; Belancourt, P. X.; MacDonald, M. J.; Doeppner, T.; Keiter, P. A.; Kuranz, C. C.; Johnsen, E.

    2017-10-01

    Recent experiments at the National Ignition Facility studied the effect of radiation on shock-driven hydrodynamic instability growth. X-ray radiography images from these experiments indicate that perturbation growth is lower in highly radiative shocks compared to shocks with negligible radiation flux. The reduction in instability growth is attributed to ablation from higher temperatures in the foam for highly radiative shocks. The proposed design implements the X-ray Thomson Scattering (XRTS) technique in the radiative shock tube platform to measure electron temperatures and densities in the shocked foam. We model these experiments with CRASH, an Eulerian radiation hydrodynamics code with block-adaptive mesh refinement, multi-group radiation transport and electron heat conduction. Simulations are presented with SiO2 and carbon foams for both the high temperature, radiative shock and the low-temperature, hydrodynamic shock cases. Calculations from CRASH give estimations for shock speed, electron temperature, effective ionization, and other quantities necessary for designing the XRTS diagnostic measurement. This work is funded by the LLNL under subcontract B614207, and was performed under the auspices of the U.S. DOE by LLNL under Contract No. DE-AC52-07NA27344.

  20. Benchmark experiment to verify radiation transport calculations for dosimetry in radiation therapy; Benchmark-Experiment zur Verifikation von Strahlungstransportrechnungen fuer die Dosimetrie in der Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Renner, Franziska [Physikalisch-Technische Bundesanstalt (PTB), Braunschweig (Germany)

    2016-11-01

    Monte Carlo simulations are regarded as the most accurate method of solving complex problems in the field of dosimetry and radiation transport. In (external) radiation therapy they are increasingly used for the calculation of dose distributions during treatment planning. In comparison to other algorithms for the calculation of dose distributions, Monte Carlo methods have the capability of improving the accuracy of dose calculations - especially under complex circumstances (e.g. consideration of inhomogeneities). However, there is a lack of knowledge of how accurate the results of Monte Carlo calculations are on an absolute basis. A practical verification of the calculations can be performed by direct comparison with the results of a benchmark experiment. This work presents such a benchmark experiment and compares its results (with detailed consideration of measurement uncertainty) with the results of Monte Carlo calculations using the well-established Monte Carlo code EGSnrc. The experiment was designed to have parallels to external beam radiation therapy with respect to the type and energy of the radiation, the materials used and the kind of dose measurement. Because the properties of the beam have to be well known in order to compare the results of the experiment and the simulation on an absolute basis, the benchmark experiment was performed using the research electron accelerator of the Physikalisch-Technische Bundesanstalt (PTB), whose beam was accurately characterized in advance. The benchmark experiment and the corresponding Monte Carlo simulations were carried out for two different types of ionization chambers and the results were compared. Considering the uncertainty, which is about 0.7 % for the experimental values and about 1.0 % for the Monte Carlo simulation, the results of the simulation and the experiment coincide.

  1. Radiation protection experience in Yugoslavia from the Vinca accident to nowadays

    International Nuclear Information System (INIS)

    Ninkovic, M.M

    2000-01-01

    This Paper is the expression of the author opinion about development of radiation protection in Yugoslavia from its beginning forty years ago, which might affect its status in the foreseeable future at the first decades of the 21st century. It focuses on key events in this field starting from the Vinca Accident, which happened in the October 1958, to nowadays. Shortly reviewed some of key events are: Vinca Accident; Foundation of the Radiation Protection Laboratory in the Vinca Institute; International Vinca Dosimetry Experiment; First National Symposium and foundation of the Yugoslav Radiation Protection Association; International Intercomparison Experiment on Nuclear Accident Dosimetry and, International Summer Schools and Symposium on Radiation Protection organized in Yugoslavia. Finally, some specific experimental data obtained during and after Chernobyl Accident up to nowadays in radiation protection action in Yugoslavia are presented also. (author)

  2. Biological dosimetry: the potential use of radiation-induced apoptosis in human T-lymphocytes

    International Nuclear Information System (INIS)

    Menz, R.; Andres, R.; Larsson, B.; Ozsahin, M.; Crompton, N.E.A.; Trott, K.

    1997-01-01

    An assay for biological dosimetry based on the induction of apoptosis in human T-lymphocytes is described. Radiation-induced apoptosis was assessed by flow cytometric identification of cells displaying apoptosis-associated DNA condensation. CD4 and CD8 T-lymphocytes were analysed. They were recognized on the basis of their cell-surface antigens. Four parameters were measured for both cell types: cell size, granularity, antigen immunofluorescence and DNA content. Apoptosis was quantified as the fraction of CD4-, or CD8-positive cells with a characteristic reduction of cell size and DNA content. At doses below 1 Gy, levels of radiation-induced apoptosis increased for up to 5 days after irradiation. Optimal dose discrimination was observed 4 days after irradiation, at which time the dose-response curves were linear, with a slope of 8% ± 0.5% per 0.1 Gy. In controlled, dose-response experiments the lowest dose level at which the radiation-induced apoptosis frequency was still significantly above control was 0.05 Gy. After 5 days post-irradiation incubation, intra- and interdonor variations were measured and found to be similar; thus, apoptotic levels depend more on the dose than on the donor. The results demonstrate the potential of this assay as a biological dosimeter. (orig.)

  3. Radiation induced bystander effects in modification of cellular radio-sensitivity in human cancer cells

    International Nuclear Information System (INIS)

    Pandey, B.N.

    2012-01-01

    Radiation-induced Bystander Effect is manifestation of radiation effects in non-irradiated cells in the population. The phenomenon may have significant implication in risk of radiation induced cancer incidence and outcome of cancer radiotherapy. To understand the bystander interaction in tumor cells, we have studied secretion of diffusible factors from control and irradiated tumor cells of different origin. Our results showed a good correlation between magnitude of secretion of diffusible factors and survival of tumor cells. These diffusible factors are shown to affect proliferation and survival of tumor cells involving regulation of kinases and genes/proteins involved in apoptotic machinery. Our experiments using pharmacological inhibitors showed involvement of activating transcription factor 2 (ATF-2) signaling in survival of tumor cells after treatment with diffusible factors. These factors seem to be involved in exerting radio-resistance in tumor cells. Furthermore, in proton microbeam irradiation studies showed induction of double strand break measured as gH2AX foci in human lung carcinoma cells, which was found to propagate to bystander tumor cells during post-irradiation incubation. Implication of these observations in outcome of cancer radiotherapy scenario would be discussed. (author)

  4. Human exposure to radiation following the release of radioactivity from a reactor accident: a quantitative assessment of the biological consequences

    International Nuclear Information System (INIS)

    Smith, H.; Stather, J.W.

    1976-11-01

    The objective of this review is to provide a biological basis upon which to assess the consequences of the exposure of a population to radioactivity released after a reactor accident. Depending upon the radiation dose, both early and late somatic damage could occur in the exposed population and hereditary effects may occur in their descendants. The development of dose-effect relationships has been based upon the limited amount of information available on humans, supplemented by data obtained from experiments on animals. (author)

  5. Elevation of telomerase activity in chronic radiation ulcer of human skin

    International Nuclear Information System (INIS)

    Li Xiaoying; Zhao Po; Wang Dewen; Yang Zhixiang

    1997-01-01

    Objective: To investigate the levels of telomerase activity in chronic radiation ulcers of human skin and the possible relationship between the enzyme and cancer transformation. Method: Using nonisotopic telomere repeat amplification protocol (TRAP), detections were performed in 20 cases of chronic radiation ulcers of human skin, 5 cases of normal skin tissues and 5 cases of carcinoma. Results: The positive rates for telomerase activity were 30.0%(6/20), 0(0/5) and 100%(5/5) in chronic radiation ulcers of human skin, normal skin and carcinoma, respectively. The telomerase activity in radiation ulcer was weaker than in carcinoma. Conclusion: The telomerase activity assay might be used as a marker for predicting the prognosis and the effect of treatment in chronic radiation ulcer of human skin

  6. ARM Enhanced Shortwave Experiment (ARESE) Solar Radiation Data

    Data.gov (United States)

    National Aeronautics and Space Administration — The ARM Enhanced Shortwave Experiment (ARESE) was conducted at the Department of Energy's ARM Southern Great Plains (SGP) Central Facility between September 22, 1995...

  7. Pilot scale experiments on radiation vulcanization of NR latex

    Science.gov (United States)

    Ridwan, M.

    The potential of irradiated latex as raw material of commercial use is under testing on pilot plant scale in Indonesia which has 225 kCi Co-60 irradiation facility and can irradiate 1000 tonnes of centrifuged latex per annum. The facility was jointly designed by BATAN of Indonesia and JAERI of Japan and was jointly financed by UNDP/IAEA, Government of Japan and Government of Indonesia under UNDP/IAEA Regional Cooperative Agreement Project on Industrial Application of Isotopes and Radiation Technology. The facility is a water pool type and can accomodate 400 kCi Co-60. The Co-60 rack has two shapes, plate and cylindrical shapes. The plate shape source is used for natural rubber latex irradiation and the cylindrical one is used for other irradiation services. The vulcanization system consists of three major components : emulsification unit ( height : 650 mm, diameter 500 mm ), mixing unit ( height : 1900mm, diameter 1200 mm ) and vulcanization reactor ( height : 1800 mm, diameter 1300 mm ). The first two components are located outside shielded room while the third one-in irradiation room. The radiation vulcanization process is a much simpler energy saving process comparedto the conventional thermal process which has two vulcanization steps before and after dipping. The physical and mechanical properties of irradiated NR Latex are comparable to those of sulfur vulcanized, and depend on many factors such as irradiation dose, sensitizer content, dry rubber content and storage time.

  8. Pilot scale experiments on radiation vulcanization of NR latex

    International Nuclear Information System (INIS)

    Ridwan, M.

    1985-01-01

    The potential of irradiated latex as raw material of commercial use is under testing on pilot plant scale in Indonesia which has 225 kCi Co-60 irradiation facility and can irradiate 1000 tonnes of centrifuged latex per annum. The facility was jointly designed by BATAN of Indonesia and JAERI of Japan and was jointly financed by UNDP/IAEA, Government of Japan and Government of Indonesia under UNDP/IAEA Regional Cooperative Agreement Project on Industrial Application of Isotopes and Radiation Technology. The facility is a water pool type and can accommodate 400 kCi Co-60. The Co-60 rack has two shapes, plate and cylindrical shapes. The plate shape source is used for natural rubber latex irradiation and the cylindrical one is used for other irradiation services. The vulcanization system consists of three major components: emulsification unit, mixing unit and vulcanization reactor. The first two components are located outside shielded room while the third one in irradiation room. The radiation vulcanization process is a much simpler energy saving process compared to the conventional thermal process which has two vulcanization steps before and after dipping. The physical and mechanical properties of irradiated NR latex are comparable to those of sulfur vulcanized. (author)

  9. Macquarie Island Cloud and Radiation Experiment (MICRE) Science Plan

    Energy Technology Data Exchange (ETDEWEB)

    Marchand, RT [University of Washington; Protat, A [Australian Bureau of Meterology; Alexander, SP [Australian Antarctic Division

    2015-12-01

    Clouds over the Southern Ocean are poorly represented in present day reanalysis products and global climate model simulations. Errors in top-of-atmosphere (TOA) broadband radiative fluxes in this region are among the largest globally, with large implications for modeling both regional and global scale climate responses (e.g., Trenberth and Fasullo 2010, Ceppi et al. 2012). Recent analyses of model simulations suggest that model radiative errors in the Southern Ocean are due to a lack of low-level postfrontal clouds (including clouds well behind the front) and perhaps a lack of supercooled liquid water that contribute most to the model biases (Bodas-Salcedo et al. 2013, Huang et al. 2014). These assessments of model performance, as well as our knowledge of cloud and aerosol properties over the Southern Ocean, rely heavily on satellite data sets. Satellite data sets are incomplete in that the observations are not continuous (i.e., they are acquired only when the satellite passes nearby), generally do not sample the diurnal cycle, and view primarily the tops of cloud systems (especially for the passive instruments). This is especially problematic for retrievals of aerosol, low-cloud properties, and layers of supercooled water embedded within (rather than at the top of) clouds, as well as estimates of surface shortwave and longwave fluxes based on these properties.

  10. Romanian experience on safety and security of radiation sources

    International Nuclear Information System (INIS)

    Botgros, Madalina; Coroianu, Anton; Negreanu, Mircea

    2008-01-01

    Romania has established the first administrative structure for controlling the deployment of the nuclear activities in 1961 and the first Romanian nuclear law was published in 1974. In the present, it is in force the Law no. 111, published in 1996 and republished in 2003. Moreover, there are available facilities and services to the persons authorized to manage radioactive sources. The regulation for safety and security of radioactive sources was amended two times in order to implement the international recommendations for setting up the national system for accounting and control of radiation sources and to coordinate the recovery activities. As part of national control programme, the national inventory of sources and devices is updated permanently, when issuing a new authorization, when modifying an existing one, or when renewing an authorization system and records in the database. The government responsibility for the orphan sources is stated in the law on radioactive waste management and decommissioning fund. There is a protocol between CNCAN, Ministry of Internal and Ministry of Health and Family regarding the co-operation in the case of finding orphan sources. When a radiation source is spent, it becomes radioactive waste that has to be disposed off properly. Depending on the case, the holder of a spent source has the possibility either to return the radioactive source to its manufacturer for regeneration or to transfer it to the Radioactive Waste Treatment Facility. (author)

  11. Animation, embodiment, and digital media human experience of technological liveliness

    CERN Document Server

    Chow, K

    2013-01-01

    Animation, Embodiment and Digital Media articulates the human experience of technology-mediated animated phenomena in terms of sensory perception, bodily action and imaginative interpretation, suggesting a new theoretical framework with analyses of exemplary user interfaces, video games and interactive artworks.

  12. Neuroscience and the Soul: Competing Explanations for the Human Experience

    Science.gov (United States)

    Preston, Jesse Lee; Ritter, Ryan S.; Hepler, Justin

    2013-01-01

    The development of fMRI techniques has generated a boom of neuroscience research across the psychological sciences, and revealed neural correlates for many psychological phenomena seen as central to the human experience (e.g., morality, agency). Meanwhile, the rise of neuroscience has reignited old debates over mind-body dualism and the soul.…

  13. Clinical Experiences with Radiation Induced Thyroid Cancer after Chernobyl

    Directory of Open Access Journals (Sweden)

    Christoph Reiners

    2011-05-01

    Full Text Available The risk of developing thyroid cancer increases considerably after exposure to external or internal radiation, especially in children below the age of 10. After the Chernobyl reactor accident, the yearly incidence of childhood thyroid cancer in Belarus increased to approximately 40 per 1.000.000 in girls and to roughly 20 per 1.000.000 in boys compared to approximately 0.5 cases per 1.000.000 prior to the accident. Typically, young children with thyroid cancer after radiation exposure present in ≈95% of the cases as papillary cancers, in ≈50% as invasive tumors growing outside the thyroid capsule, in ≈65% with lymph node metastases and in ≈15% with distant metastases. A joint Belarusian-German project starting in April 1993 that combined treatment with surgery and radioiodine was organized in 237 selected children from Belarus who were exposed to the Chernobyl fallout and had advanced stages of thyroid cancer. The study group included 141 girls and 96 boys. Their median age at the time of the accident was 1.7 years; whereas the median age at the time of diagnosis was 12.4 years. With the exception of two cases with follicular histology, the majority of the patients had been diagnosed with papillary thyroid cancers. In 63%, the tumor had grown outside the thyroid capsule and invaded the tissue of the neck (pT4. Nearly all of the selected cases (96% showed-up with lymph node metastases (pN1 and 43% of the patients with distant metastases mainly to the lungs (pM1. In 58% of the children, complete remissions of thyroid cancer could be achieved until December 31st 2010 and in 34% of the children, stable partial remissions; in the remaining 8% of the patients, partial remissions were observed. The risk of radiation-induced thyroid cancer increased considerably in children and adolescents who were affected by the Chernobyl reactor accident. In spite of the fact, that thyroid cancers in young children seem to behave more aggressively than in

  14. Adjuvant chemo-radiation for gastric adenocarcinoma: an institutional experience

    International Nuclear Information System (INIS)

    Aftimos, Philippe G; Nasr, Elie A; Nasr, Dolly I; Noun, Roger J; Nasr, Fady L; Ghosn, Marwan G; El Helou, Joelle A; Chahine, Georges Y

    2010-01-01

    Studies have shown that surgery alone is less than satisfactory in the management of early gastric cancer, with cure rates approaching 40%. The role of adjuvant therapy was indefinite until three large, randomized controlled trials showed the survival benefit of adjuvant therapy over surgery alone. Chemoradiation therapy has been criticized for its high toxicity. 24 patients diagnosed between September 2001 and July 2007 were treated with adjuvant chemoradiation. 18 patients had the classical MacDonald regimen of 4500 cGy of XRT and chemotherapy with 5-fluorouracil (5FU) and leucovorin, while chemotherapy consisted of 5FU/Cisplatin for 6 patients. This series consisted of non-metastatic patients, 17 females and 7 males with a median age of 62.5 years. 23 patients (96%) had a performance status of 0 or 1. The full course of radiation therapy (4500 cGy) was completed by 22 patients (91.7%). Only 7 patients (36.8%) completed the total planned courses of chemotherapy. 2 local relapses (10%), 2 regional relapses (10%) and 2 distant relapses (10%) were recorded. Time to progression has not been reached. 9 patients (37.5%) died during follow-up with a median overall survival of 75 months. Patients lost a mean of 4 Kgs during radiation therapy. We recorded 6 episodes of febrile neutropenia and the most frequent toxicity was gastro-intestinal in 17 patients (70.8%) with 9 (36%) patients suffering grade 3 or 4 toxicity and 5 patients (20%) suffering from grade 3 or 4 neutropenia. 4 (17%) patients required total parenteral nutrition for a mean duration of 20 days. 4 patients suffered septic shock (17%) and 1 patient developed a deep venous thrombosis and a pulmonary embolus. Adjuvant chemo-radiation for gastric cancer is a standard at our institution and has resulted in few relapses and an interesting median survival. Toxicity rates were serious and this remains a harsh regimen with only 36.8% of patients completing the full planned courses of chemotherapy. This is due to

  15. Adjuvant chemo-radiation for gastric adenocarcinoma: an institutional experience

    Directory of Open Access Journals (Sweden)

    Ghosn Marwan G

    2010-06-01

    Full Text Available Abstract Background Studies have shown that surgery alone is less than satisfactory in the management of early gastric cancer, with cure rates approaching 40%. The role of adjuvant therapy was indefinite until three large, randomized controlled trials showed the survival benefit of adjuvant therapy over surgery alone. Chemoradiation therapy has been criticized for its high toxicity. Methods 24 patients diagnosed between September 2001 and July 2007 were treated with adjuvant chemoradiation. 18 patients had the classical MacDonald regimen of 4500 cGy of XRT and chemotherapy with 5-fluorouracil (5FU and leucovorin, while chemotherapy consisted of 5FU/Cisplatin for 6 patients. Results This series consisted of non-metastatic patients, 17 females and 7 males with a median age of 62.5 years. 23 patients (96% had a performance status of 0 or 1. The full course of radiation therapy (4500 cGy was completed by 22 patients (91.7%. Only 7 patients (36.8% completed the total planned courses of chemotherapy. 2 local relapses (10%, 2 regional relapses (10% and 2 distant relapses (10% were recorded. Time to progression has not been reached. 9 patients (37.5% died during follow-up with a median overall survival of 75 months. Patients lost a mean of 4 Kgs during radiation therapy. We recorded 6 episodes of febrile neutropenia and the most frequent toxicity was gastro-intestinal in 17 patients (70.8% with 9 (36% patients suffering grade 3 or 4 toxicity and 5 patients (20% suffering from grade 3 or 4 neutropenia. 4 (17% patients required total parenteral nutrition for a mean duration of 20 days. 4 patients suffered septic shock (17% and 1 patient developed a deep venous thrombosis and a pulmonary embolus. Conclusions Adjuvant chemo-radiation for gastric cancer is a standard at our institution and has resulted in few relapses and an interesting median survival. Toxicity rates were serious and this remains a harsh regimen with only 36.8% of patients completing the

  16. Diamond Ordinance Radiation Facility (DORF) reactor operating experiences

    International Nuclear Information System (INIS)

    Gieseler, Walter

    1970-01-01

    The Diamond Ordnance Radiation Facility Mark F Reactor is described and some of the problems encountered with its operation are discussed. In a period from reactor startup in September 1961 to June 1964, when the aluminum-clad core was changed to a stainless-steel clad core, a total of 30 fuel elements were removed from reactor service because of excessive growth. One leaking fuel element was detected during the lifetime of the aluminum- clad core. In June 1964, the core was changed to the stainless-steel-clad high hydride fuel elements. Since the installation of the stainless-steel-clad fuel element core, there has been a gradual decline of excess reactivity. Various theories were discussed as the cause but the investigations have resulted in no definitive conclusion that could account for the total reactivity loss

  17. Radiative Transfer Theory Verified by Controlled Laboratory Experiments

    Science.gov (United States)

    Mishchenko, Michael I.; Goldstein, Dennis H.; Chowdhary, Jacek; Lompado, Arthur

    2013-01-01

    We report the results of high-accuracy controlled laboratory measurements of the Stokes reflection matrix for suspensions of submicrometer-sized latex particles in water and compare them with the results of a numerically exact computer solution of the vector radiative transfer equation (VRTE). The quantitative performance of the VRTE is monitored by increasing the volume packing density of the latex particles from 2 to 10. Our results indicate that the VRTE can be applied safely to random particulate media with packing densities up to 2. VRTE results for packing densities of the order of 5 should be taken with caution, whereas the polarized bidirectional reflectivity of suspensions with larger packing densities cannot be accurately predicted. We demonstrate that a simple modification of the phase matrix entering the VRTE based on the so-called static structure factor can be a promising remedy that deserves further examination.

  18. Radiation effects in nematodes: Results from IML-1 experiments

    Science.gov (United States)

    Nelson, G. A.; Schubert, W. W.; Kazarians, G. A.; Richards, G. F.; Benton, E. V.; Benton, E. R.; Henke, R.

    1994-01-01

    The nematode Caenorhabditis elegans was exposed to natural space radiation using the ESA biorack facility aboard Spacelab on International Microgravity Laboratory 1, STS-42. For the major experimental objective dormant animals were suspended in buffer or on agar or immobilized next to CR-39 plastic nuclear track detectors to correlate fluence of HZE particles with genetic events. This configuration was used to isolate mutations in a set of 350 essential genes as well as in the unc-22 structural gene. From flight samples 13 mutants in the unc-22 gene were isolated along with 53 lethal mutations from autosomal regions balanced by a translocation eT1(III;V). Preliminary analysis suggests that mutants from worms correlated with specific cosmic ray tracks may have a higher proportion of rearrangements than those isolated from tube cultures on a randomly sampled basis. Flight sample mutation rate was approximately 8-fold higher than ground controls which exhibited laboratory spontaneous frequencies.

  19. Natural ionizing radiation and human health in Serbia

    Directory of Open Access Journals (Sweden)

    Obradović-Arsić Danijela R.

    2010-01-01

    Full Text Available This paper provides information about potential effects of natural ionizing radiation on general population health. Natural radionuclides are particularly stressed, as well as health effects of high and lower doses. Radio-ecological areals have been presented for Serbia, while radiation risk has been assessed for the population of Serbia according to census years.

  20. Radiation between segments of the seated human body

    DEFF Research Database (Denmark)

    Sørensen, Dan Nørtoft

    2002-01-01

    Detailed radiation properties for a thermal manikin were predicted numerically. The view factors between individual body-segments and between the body-segments and the outer surfaces were tabulated. On an integral basis, the findings compared well to other studies and the results showed...... that situations exist for which radiation between individual body segments is important....

  1. Final result of the Munich-Frascati gravitational radiation experiment

    International Nuclear Information System (INIS)

    Kafka, P.; Schnupp, L.

    1977-02-01

    Within 580 days of usable common observation time between July 1973 and February 1976, this Weber-type coincidence experiment had set the lowest upper limits to the rates of gravitational wave pulses. We report the total result up to the dismantling of the detectors. We also describe a reevaluation of our data using Weber's preferred algorithm for two months in 1974 during which Weber communicated to have found a particularly significant effect in his own experiment. Finally, we confront the negative results with the far aims of gravitational pulse astronomy. (orig.) [de

  2. Final result of the Munich-Frascati gravitational radiation experiment

    International Nuclear Information System (INIS)

    Kafka, P.; Schnupp, L.

    1978-01-01

    Within 580 days of usable common observation time between July 1973 and February 1976, this Weber-type coincidence experiment had set the lowest upper limits to the rates of gravitational wave pulses. We report the total result up to the dismantling of the detectors. We also describe a re-evaluation of our data using Weber's preferred algorithm for two months in 1974 during which Weber communicated to have found a particularly significant effect in his own experiment. Finally, we confront the negative results with the far aims of gravitational pulse astronomy. (orig.) [de

  3. Experiences with radiation portal detectors for international rail transport

    Science.gov (United States)

    Stromswold, D. C.; McCormick, K.; Todd, L.; Ashbaker, E. D.; Evans, J. C.

    2006-08-01

    Radiation detectors monitored trains at two international borders to evaluate the performance of NaI(Tl) and plastic (polyvinyltoluene: PVT) gamma-ray detectors to characterize rail cargo. The detectors included a prototype NaI(Tl) radiation-portal-monitor panel having four large detectors (10-cm × 10-cm × 41-cm) and a PVT panel with a 41 cm × 173 cm × 3.8-cm detector. Spectral data from the NaI(Tl) and PVT detectors were recorded. Of particular emphasis was the identification of naturally occurring radioactive material (NORM) and the resultant frequency of nuisance alarms. For rail monitoring, the difficulty in stopping trains to perform secondary inspection on alarming cars creates a need for reliable identification of NORM during initial screening. Approximately 30 trains were monitored, and the commodities in individual railcars were ascertained from manifest information. At one test site, the trains carried inter-modal containers that had been unloaded from ships, and at the other site, the trains contained bulk cargo in tanker cars and hopper cars or individual items in boxcars or flatbeds. NORM encountered included potash, liquefied petroleum gas, fireworks, televisions, and clay-based products (e.g., pottery). Analysis of the spectral data included the use of the template-fitting portion of the program GADRAS developed at Sandia National Laboratories. For most of the NORM, the NaI(Tl) data produced a correct identification of the radionuclides present in the railcars. The same analysis was also used for PVT data in which the spectral information (no peaks but only gradual spectral changes including Compton edges) was limited. However, the PVT analysis provided correct identification of 40K and 226Ra in many cases.

  4. Experiences with radiation portal detectors for international rail transport

    International Nuclear Information System (INIS)

    Stromswold, David C.; McCormick, Kathleen R.; Todd, Lindsay C.; Ashbaker, Eric D.; Evans, J.C.

    2006-01-01

    Radiation detectors monitored trains at two international borders to evaluate the performance of NaI(Tl) and plastic (polyvinyltoluene: PVT) gamma-ray detectors to characterize rail cargo. The detectors included a prototype NaI(Tl) radiation-portal-monitor panel having four large detectors (10-cm x 10-cm x 41-cm) and a PVT panel with a 41 cm x 173 cm x 3.8-cm detector. Spectral data from the NaI(Tl) and PVT detectors were recorded. Of particular emphasis was the identification of naturally occurring radioactive material (NORM) and the resultant frequency of nuisance alarms. For rail monitoring, the difficulty in stopping trains to perform secondary inspection on alarming cars creates a need for reliable identification of NORM during initial screening. Approximately 30 trains were monitored, and the commodities in individual railcars were ascertained from manifest information. At one test site the trains carried inter-modal containers that had been unloaded from ships, and at the other site the trains contained bulk cargo or individual items in boxcars or flatbeds. NORM encountered included potash, liquefied petroleum gas, fireworks, televisions, and clay-based products (e.g., pottery). Analysis of the spectral data included the use of the template-fitting program GADRAS/FitToDB from Sandia National Laboratories. For much of the NORM the NaI(Tl) data produced a correct identification of the radionuclides present in the railcars. The same analysis was also used for PVT data in which the spectral information (no peaks but only gradual spectral changes including Compton edges) was limited. However, the PVT analysis provided correct identification of 40K and 226Ra in many cases

  5. Radiation

    International Nuclear Information System (INIS)

    Winther, J.F.; Ulbak, K.; Dreyer, L.; Pukkala, E.; Oesterlind, A.

    1997-01-01

    Exposure to solar and ionizing radiation increases the risk for cancer in humans. Some 5% of solar radiation is within the ultraviolet spectrum and may cause both malignant melanoma and non-melanocytic skin cancer; the latter is regarded as a benign disease and is accordingly not included in our estimation of avoidable cancers. Under the assumption that the rate of occurrence of malignant melanoma of the buttocks of both men and women and of the scalp of women would apply to all parts of the body in people completely unexposed to solar radiation, it was estimated that approximately 95% of all malignant melanomas arising in the Nordic populations around the year 2000 will be due to exposure to natural ultraviolet radiation, equivalent to an annual number of about 4700 cases, with 2100 in men and 2600 in women, or some 4% of all cancers notified. Exposure to ionizing radiation in the Nordic countries occurs at an average effective dose per capita per year of about 3 mSv (Iceland, 1.1 mSv) from natural sources, and about 1 mSv from man-made sources. While the natural sources are primarily radon in indoor air, natural radionuclides in food, cosmic radiation and gamma radiation from soil and building materials, the man-made sources are dominated by the diagnostic and therapeutic use of ionizing radiation. On the basis of measured levels of radon in Nordic dwellings and associated risk estimates for lung cancer derived from well-conducted epidemiological studies, we estimated that about 180 cases of lung cancer (1% of all lung cancer cases) per year could be avoided in the Nordic countries around the year 2000 if indoor exposure to radon were eliminated, and that an additional 720 cases (6%) could be avoided annually if either radon or tobacco smoking were eliminated. Similarly, it was estimated that the exposure of the Nordic populations to natural sources of ionizing radiation other than radon and to medical sources will each give rise to an annual total of 2120

  6. International human rights for mentally ill persons: the Ontario experience.

    Science.gov (United States)

    Zuckerberg, Joaquin

    2007-01-01

    This article is part of a working project which assesses Ontario's mental health legislation and practice vis-à-vis international human rights standards. The paper focuses on procedural safeguards provided by the major international human rights instruments in the field of mental health law such as the UN Principles for the Protection of Persons with Mental Illness (MI Principles) and the European Convention on Human Rights as interpreted by the European Human Rights Court. In analysing Ontario's compliance with international standards, the paper will explore some problems arising from the implementation of the legislation with which the author is familiar with from his experience as counsel for the Consent and Capacity Board. The paper aims to generate discussion for potential reforms in domestic legal systems and to provide a methodology to be used as a tool to assess similar mental health legislation in other local contexts.

  7. The effect of low dose ionizing radiation on homeostasis and functional integrity in an organotypic human skin model

    Energy Technology Data Exchange (ETDEWEB)

    Neubeck, Claere von [German Cancer Consortium DKTK partner site Dresden, OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden (Germany); German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg (Germany); Geniza, Matthew J. [Molecular and Cellular Biology Program, Oregon State University, Corvallis OR 97331 (United States); Kauer, Paula M.; Robinson, R. Joe; Chrisler, William B. [Health Impacts and Exposure Science, Pacific Northwest National Laboratory, Richland WA 99352 (United States); Sowa, Marianne B., E-mail: marianne.sowa@pnnl.gov [Health Impacts and Exposure Science, Pacific Northwest National Laboratory, Richland WA 99352 (United States)

    2015-05-15

    Highlights: • Low doses of high LET radiation influence skin homeostasis. • Effects on proliferation and differentiation profiles are LET dependent. • Skin barrier function is not compromised following low dose exposure. - Abstract: Outside the protection of Earth's atmosphere, astronauts are exposed to low doses of high linear energy transfer (LET) radiation. Future NASA plans for deep space missions or a permanent settlement on the moon are limited by the health risks associated with space radiation exposures. There is a paucity of direct epidemiological data for low dose exposures to space radiation-relevant high LET ions. Health risk models are used to estimate the risk for such exposures, though these models are based on high dose experiments. There is increasing evidence, however, that low and high dose exposures result in different signaling events at the molecular level, and may involve different response mechanisms. Further, despite their low abundance, high LET particles have been identified as the major contributor to health risk during manned space flight. The human skin is exposed in every external radiation scenario, making it an ideal epithelial tissue model in which to study radiation induced effects. Here, we exposed an in vitro three dimensional (3-D) human organotypic skin tissue model to low doses of high LET oxygen (O), silicon (Si) and iron (Fe) ions. We measured proliferation and differentiation profiles in the skin tissue and examined the integrity of the skin's barrier function. We discuss the role of secondary particles in changing the proportion of cells receiving a radiation dose, emphasizing the possible impact on radiation-induced health issues in astronauts.

  8. Ceiling art in a radiation therapy department: its effect on patient treatment experience

    International Nuclear Information System (INIS)

    Bonett, Jotham

    2015-01-01

    A new initiative has been implemented at the Sunshine Hospital Radiation Therapy Centre, to provide a calming and comforting environment for patients attending radiation therapy treatment. As part of this initiative, the department's computed tomography (CT) room and radiation therapy bunkers were designed to incorporate ceiling art that replicates a number of different visual scenes. The study was undertaken to determine if ceiling art in the radiation therapy treatment CT and treatment bunkers had an effect on a patient's experience during treatment at the department. Additionally, the study aimed to identify which of the visuals in the ceiling art were most preferred by patients. Patients were requested to complete a 12-question survey. The survey solicited a patient's opinion/perception on the unit's unique ceiling display with emphasis on aesthetic appeal, patient treatment experience and the patient's engagement due to the ceiling display. The responses were dichotomised to ‘positive’ or ‘negative’. Every sixth patient who completed the survey was invited to have a general face-to-face discussion to provide further information about their thoughts on the displays. The results demonstrate that the ceiling artwork solicited a positive reaction in 89.8% of patients surveyed. This score indicates that ceiling artwork contributed positively to patients’ experiences during radiation therapy treatment. The study suggests that ceiling artwork in the department has a positive effect on patient experience during their radiation therapy treatment at the department

  9. Ceiling art in a radiation therapy department: its effect on patient treatment experience

    Energy Technology Data Exchange (ETDEWEB)

    Bonett, Jotham [Sunshine Hospital Radiation Therapy Centre, Melbourne, Vic. (Australia)

    2015-09-15

    A new initiative has been implemented at the Sunshine Hospital Radiation Therapy Centre, to provide a calming and comforting environment for patients attending radiation therapy treatment. As part of this initiative, the department's computed tomography (CT) room and radiation therapy bunkers were designed to incorporate ceiling art that replicates a number of different visual scenes. The study was undertaken to determine if ceiling art in the radiation therapy treatment CT and treatment bunkers had an effect on a patient's experience during treatment at the department. Additionally, the study aimed to identify which of the visuals in the ceiling art were most preferred by patients. Patients were requested to complete a 12-question survey. The survey solicited a patient's opinion/perception on the unit's unique ceiling display with emphasis on aesthetic appeal, patient treatment experience and the patient's engagement due to the ceiling display. The responses were dichotomised to ‘positive’ or ‘negative’. Every sixth patient who completed the survey was invited to have a general face-to-face discussion to provide further information about their thoughts on the displays. The results demonstrate that the ceiling artwork solicited a positive reaction in 89.8% of patients surveyed. This score indicates that ceiling artwork contributed positively to patients’ experiences during radiation therapy treatment. The study suggests that ceiling artwork in the department has a positive effect on patient experience during their radiation therapy treatment at the department.

  10. Assessment of radiation induced cytogenetic damage in human keratinocytes by comet assay

    International Nuclear Information System (INIS)

    Joseph, Praveen; Sanjeev Ganesh; Narayana, Y.; Puthali, Abhay; Bhat, N.N.

    2010-01-01

    In the present study the effect of gamma radiation on normal human keratinocytes (HaCaT) cells has been analyzed using alkaline comet assay and a comparative study over the sensitivity of different comet parameters such as tail length (TL), olive tail moment (OTM) and percentage tail DNA (TDNA) has also been made. Human keratinocytes (HaCaT) cells were grown in Dulbecco's modified essential medium (DMEM) (10% FCS) at 37 °C in a humidified atmosphere containing 5% CO 2 . Cultured cells were harvested with 0.025 % trypsin EDTA. The sample (2 X 10 cells/ml) was exposed to gamma radiation of different dose using a 60 Co gamma source at dose rate of 2 Gy min -1 and the dosimetry has been carried out using Fricke and FBX dosimeters. After irradiation, to quantify the DNA damage the comet assay (single cell gel electrophoresis) was carried out under alkaline conditions, by the methods outlined by Singh et al. The quantification of the DNA strand breaks in each cells were performed using CASP software. The DNA damage quantification can be accomplished by measuring those comet parameters which exhibit a linear dependence on the amount of DNA damage. In the present study, comet parameters such as OTM, TL and TDNA were recorded and the variation of these parameters and their correlation coefficients for different doses of gamma radiation is plotted. The OTM value is normalized with control value and control for TL and TDNA is adjusted to zero to avoid initial variations in different experiments

  11. Radiation response of drug-resistant variants of a human breast cancer cell line

    International Nuclear Information System (INIS)

    Lehnert, S.; Greene, D.; Batist, G.

    1989-01-01

    The radiation response of drug-resistant variants of the human tumor breast cancer cell line MCF-7 has been investigated. Two sublines, one resistant to adriamycin (ADRR) and the other to melphalan (MLNR), have been selected by exposure to stepwise increasing concentrations of the respective drugs. ADRR cells are 200-fold resistant to adriamycin and cross-resistant to a number of other drugs and are characterized by the presence of elevated levels of selenium-dependent glutathione peroxidase and glutathione-S-transferase. MLNR cells are fourfold resistant to melphalan and cross-resistant to some other drugs. The only mechanism of drug resistance established for MLNR cells to date is an enhancement of DNA excision repair processes. While the spectrum of drug resistance and the underlying mechanisms differ for the two sublines, their response to radiation is qualitatively similar. Radiation survival curves for ADRR and MLNR cells differ from that for wild-type cells in a complex manner with, for the linear-quadratic model, a decrease in the size of alpha and an increase in the size of beta. There is a concomitant decrease in the size of the alpha/beta ratio which is greater for ADRR cells than for MLNR cells. Analysis of results using the multitarget model gave values of D0 of 1.48, 1.43, and 1.67 Gy for MCF-7 cells are not a consequence of cell kinetic differences between these sublines. Results of split-dose experiments indicated that for both drug-resistant sublines the extent of sublethal damage repair reflected the width of the shoulder on the single-dose survival curve. For MCF-7 cells in the stationary phase of growth, the drug-resistant sublines did not show cross-resistance to radiation; however, delayed subculture following irradiation of stationary-phase cultures increased survival to a greater extent for ADRR and MLNR cells than for wild-type cells

  12. Safety assessment of RF and microwave radiation emitted by the mobile telephone base station (MTBS) in Malaysia: experience and challenge

    International Nuclear Information System (INIS)

    Roha Tukimin; Rozaimah Abd Rahim; Mohamad Amirul Nizam; Mohd Yusof Mohd Ali

    2007-01-01

    Non-ionising radiation (NIR) is known to be hazardous if the amount received is excessive. It is a fact that NIR, including extremely low frequency (ELF) electromagnetic fields, radiofrequency (RF) and microwave radiation can be found almost everywhere generated by both natural and man-made source. This is due to increase in demand for telecommunication and wireless technology which is become very important and as part of our lives. However, the widespread of the relevant technology contributed more NIR man-made sources exposure to the human. Due to public concern their potential of causing such health hazard, members of public and companies approached and request NIR Group of Nuclear Malaysia to carry out surveys and safety assessments of radiofrequency and microwave radiation emitted by the mobile telephone base station (MTBS) erected near the residential area or installed on the rooftop of the commercial building. Objective of the survey was to assess the presence of radiofrequency and microwave radiation and to identify radiation level which may lead to significant personnel exposure. Findings of the survey was compared to the standard guidelines issued by Malaysian Communication and Multimedia Commission (MCMC) and International Committee on Non-Ionising Radiation Protection (ICNIRP). This paper highlights the works that had been carried out by NIR Group of Nuclear Malaysia from 1997 to 2007. We will share the experience and challenge in carried out the NIR safety assessment at mobile telephone base station. Results of the assessment work will be used to develop non-ionising radiation database for future reference in Malaysia. (Author)

  13. ARM West Antarctic Radiation Experiment (AWARE) Science Plan

    Energy Technology Data Exchange (ETDEWEB)

    Lubin, D [National Science Foundation; Bromwich, DH [Ohio State University; Russell, LM [Scripps Institution of Oceanography; Verlinde, J [The Pennsylvania State University; Vogelmann, AM [Brookhaven National Laboratory

    2015-10-01

    West Antarctica is one of the most rapidly warming regions on Earth, and this warming is closely connected with global sea level rise. The discovery of rapid climate change on the West Antarctic Ice Sheet (WAIS) has challenged previous explanations of Antarctic climate change that focused on strengthening of circumpolar westerlies in response to the positive polarity trend in the Southern Annular Mode. West Antarctic warming does not yet have a comprehensive explanation: dynamical mechanisms may vary from one season to the next, and these mechanisms very likely involve complex teleconnections with subtropical and tropical latitudes. The prime motivation for this proposal is that there has been no substantial atmospheric science or climatological field work on West Antarctica since the 1957 International Geophysical Year and that research continued for only a few years. Direct meteorological information on the WAIS has been limited to a few automatic weather stations for several decades, yet satellite imagery and meteorological reanalyses indicate that West Antarctica is highly susceptible to advection of warm and moist maritime air with related cloud cover, depending on the location and strength of low pressure cells in the Amundsen, Ross, and Bellingshausen Seas. There is a need to quantify the role of these changing air masses on the surface energy balance, including all surface energy components and cloud-radiative forcing. More generally, global climate model simulations are known to perform poorly over the Antarctic and Southern Oceans, and the marked scarcity of cloud information at southern high latitudes has so far inhibited significant progress. Fortunately, McMurdo Station, where the Atmospheric Radiation Measurement Facility’s (ARM’s) most advanced cloud and aerosol instrumentation is situated, has a meteorological relationship with the WAIS via circulation patterns in the Ross and Amundsen Seas. We can therefore gather sophisticated data with cloud

  14. Approach to non-human species radiation dose assessment in the republic of Korea

    International Nuclear Information System (INIS)

    Keum, D. K.; Jun, I.; Lim, K. M.; Choi, Y. H.

    2011-01-01

    This paper describes the approach to non-human species radiation dose assessment in Korea. As the tentative reference organisms, one plant and seven animals were selected based on the new International Commission on Radiological Protection recommendation issued in 2007, and the size of the selected organisms was determined from the corresponding Korean endemic species. A set of 25 radionuclides was considered as a potential source term of causing radiological damage to organisms. External and internal dose conversion coefficients for the selected organisms and radionuclides were calculated by the uniform isotropic model or Monte Carlo simulation. Concentration ratios of some endemic species are being measured in laboratory experiments, in parallel with the review of existing data. (authors)

  15. Radiation effects on human glia and glioma cells in vitro

    International Nuclear Information System (INIS)

    Nilsson, S.

    1983-01-01

    The radiosensitivity of human glia and glioma cells has been studied in vitro, and a new cloning method has been developed to overcome the difficulties due to the very low cloning efficiency of these cells. The cells were confined to small palladium areas surrounded by agarose, which increased the cell density, but kept the clones separated. Using this method, the glia cells were found to be very sensitive to gamma irradiation (D 0 =1.0-1.5 Gy and n=1) in comparision with the glioma cells (D 0 =1.5-2.5 Gy and n=3.5). The induction and repair of DNA strand breaks were studied with two DNA unwinding techniques. No differences between the two cell-lines were detected when induction and fast repair were studied with the single-labelling method, while the glioma cells showed less unrepaired DNA strand breaks than the glia cells after 1, 2 and 3 hours, when the double-labelling method was used. Detachment, attachment and growth kinetics were studied using the palladium-agarose cloning method. All of the glioma cell-lines studied, detached and attached themselves at rates higher than the normal diploid glia cell-lines. All of the cell-lines contained clones with different properties. Some clones were rapidly growing, others maintained a nearly constant number of cells or even decreased. The effects of chronic hypoxia were tested in a few experiments. Low oxygen tension in the culture medium reduced the rate of growth and the DNA synthesis of the glioma cells. The present study indicates that cultured human glioma cells are less radiosensitive than cultured glia cells. The palladium-agarose technique, enable studying growth kinetics detachment, attachment and radiosensitivity in a quantitative manner for cells with low cloning efficiency. (author)

  16. Effect of recombinant adenovirus encoding human p53 tumor suppressor gene combined with radiation therapy on human lymphoma cells lines

    International Nuclear Information System (INIS)

    Yu Zeyang; Fan Wo; Li Dongqing; Zhu Ran; Wan Jianmei; Wang Yongqing; Wu Jinchang

    2008-01-01

    This paper analyzes the inhibitory effect and radiation sensitization of recombinant adenovirus encoding human p53 tumor suppressor gene (rAd-p53) on human lymphoma cell lines. Human lymphoma cell lines were treated with rAd-p53, radiation therapy and combined treatment, respectively. The cell growth inhibition was assessed by MTF. The cell cycle and apoptosis were detected by flow cytometry, and the p53 protein expression was detected by Western blotting. The results showed that extrinsic p53 gene have expressed to some degree, but not at high level. The role of inhibition and radiation sensitivity of rAd-p53 was not significant to human lymphoma cell lines. (authors)

  17. Experiments in atomic and applied physics using synchrotron radiation

    International Nuclear Information System (INIS)

    Jones, K.W.

    1987-01-01

    A diverse program in atomic and applied physics using x rays produced at the X-26 beam line at the Brookhaven National Synchrotron Light Source is in progress. The atomic physics program studies the properties of multiply-ionized atoms using the x rays for photo-excitation and ionization of neutral atoms and ion beams. The applied physics program builds on the techniques and results of the atomic physics work to develop new analytical techniques for elemental and chemical characterization of materials. The results are then used for a general experimental program in biomedical sciences, geo- and cosmochemistry, and materials sciences. The present status of the program is illustrated by describing selected experiments. Prospects for development of new experimental capabilities are discussed in terms of a heavy ion storage ring for atomic physics experiments and the feasibility of photoelectron microscopy for high spatial resolution analytical work. 21 refs., 11 figs., 2 tabs

  18. Experiences Gained from Radiation Protection Activities in Egypt and Saudi Arabia

    International Nuclear Information System (INIS)

    Kamal, S. M.

    2004-01-01

    My official duties and responsibilities in Egypt and Saudi Arabia as radiation safety officer, qualified expert and head of dosimetry section covered the specified branch of radiation protection. This branch may be called Applied Radiation Protection. This branch covers all aspects of personal and environmental dosimetry and monitoring, as well as, radiation measurements and shielding. This branch has been implemented at many universities, medical centers and nuclear organizations in both Egypt and Saudi Arabia. As a result, three subjects have been highlighted 1] Radiation Protection of workers, public and environment, 2) Safety of radioactive materials to ensure its control and 3) Security from unauthorized removal. A program has been proposed as (RPSS program). In this program, radiation workers are responsible for the security of all radioactive materials in their possession including radioactive waste in storage cabinets and sources left unattended on laboratory benches. Occupational radiation exposures have been kept below dose limits at all radiation areas by training increased experience and ability of radiation workers. All radioactive materials that are not in locked storage are under constant surveillance and immediate control at all times by Radiation Safety Officer (RSO) or medical physicist departments. Precautionary measures serve as a guide to safe operations in handling radioactive materials and radiation sources. Certain restricted areas, which contain large quantities of radioactive materials, required additional security measures. Implementation of this program led to secure of radioactive materials from unauthorized removal or access, public health, maintaining exposures as low as reasonably achievable and promoting a protective safe working environment with no contamination. It is recommended to include this program in Radiation Protection Manual and Emergency preparedness procedures at academic institutions, nuclear research facilities and

  19. An initial assessment of the impact of Australian aerosols on surface ultraviolet radiation and implications for human health

    International Nuclear Information System (INIS)

    Chee, C Y; Mills, F P

    2010-01-01

    Aerosols can have significant influence on surface radiation, and the intense surface ultraviolet radiation Australia experiences contributes to Australia's high incidence rates for related human diseases. Aerosol properties, such as total column aerosol optical depth, have been measured over several years for varying lengths of time at sites across Australia using sunphotometers. Statistical analysis of the average daily aerosol optical depth over sites near Alice Springs, Canberra, Darwin, and Perth provides one measure of the annual atmospheric loading of aerosols over these sites. The sunphotometers used at these sites do not make measurements in the UV-B spectral region and have only one channel in the UV-A spectral region, the regions of most interest for assessing human health impact. Consequently, model calculations using standard aerosol types have been used to make an initial estimate of the impact of the aerosols found over these four sites on surface ultraviolet radiation. The aerosol loading is at times sufficient to significantly reduce the surface ultraviolet radiation, but few such days occur each year. The annual average effect of aerosols on surface ultraviolet radiation, thus, appears to be small compared to lifestyle factors, such as clothing and use of sunscreen.

  20. Acceptability of risk from radiation: Application to human space flight

    International Nuclear Information System (INIS)

    1997-01-01

    This one of NASA's sponsored activities of the NCRP. In 1983, NASA asked NCRP to examine radiation risks in space and to make recommendations about career radiation limits for astronauts (with cancer considered as the principal risk). In conjunction with that effort, NCRP was asked to convene this symposium; objective is to examine the technical, strategic, and philosophical issues pertaining to acceptable risk and radiation in space. Nine papers are included together with panel discussions and a summary. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database

  1. Acceptability of risk from radiation: Application to human space flight

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-30

    This one of NASA`s sponsored activities of the NCRP. In 1983, NASA asked NCRP to examine radiation risks in space and to make recommendations about career radiation limits for astronauts (with cancer considered as the principal risk). In conjunction with that effort, NCRP was asked to convene this symposium; objective is to examine the technical, strategic, and philosophical issues pertaining to acceptable risk and radiation in space. Nine papers are included together with panel discussions and a summary. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  2. Argentine regulatory experience concerning radiation protection in industrial gammagraphy

    International Nuclear Information System (INIS)

    Ermacora, Marcela G.

    2005-01-01

    Industrial gammagraphy has always been responsible for the highest rates of radiological incidents in almost every part of the world. This is mainly due to the high activities of the radioactive sources used, which are constantly transported in the equipment that contains them between the storage and the areas of work, and is also due to workload pressures which may induce to negligence in following the operational procedures, if a strong Safety Culture does not exist. The purpose of this paper is to present the main aspects of the Argentine Regulations relating to radiation protection to control this practice and to contribute in this way to reduce the associated risks. In addition, some incidents occurred in Argentina during the latest years, the causes that led to those events and their relation to the in observance of the regulations in force, their consequences and the measures taken to repair them are described. Finally, the importance of the role that education and training has in the strengthening of Safety Culture, key element of all undertaking, is highlighted. (author) [es

  3. Experience of the use of radiation measuring instruments for Russia

    International Nuclear Information System (INIS)

    Matsubara, S.; Ohshima, T.; Kawaguti, H.

    1994-01-01

    After the Chernobyl accident, among a series of international cooperations, also from our company T.OHSHIMA visited Russia in October, 1991 as a member of the USSR and Japan Joint Specialist Meeting on Environmental Radiation and Shelter Structure of Chernobyl-4 Nuclear Power Plant, and a few members including H.KAWAGUTI visited there in December, 1991 for the handling instructions of the apparatus delivered to Sasagawa Memorial Health Cooperation Foundation. During these visits to Russia they carried electronic personal dosimeters and pocketsize dose ratemeters, measured the doses and dose rate of some areas including the actual polluted areas and gained interesting data. Especially T.OHSHIMA entered the turbine structure of Chernobyl No.4 Reactor and experienced 7m Sv/h. I introduce these measurement data and the instruments used for the measurement. Also H.KAWAGUTI and others explained the maintenance and handling of the whole body counter loaded into the medical examination car offered to Russia for Chernobyl Sasagawa Medical Care Cooperation Project of Sasagawa Memorial Health Cooperation Foundation. I introduce the outline of this medical examination car laying stress on the whole body counter and present a part of the data by the whole body counter measured during the medical care cooperation. (author)

  4. Technetium-99m in nuclear medicine and radiation protection experience

    International Nuclear Information System (INIS)

    Ninkovic, M. M.; Raicevic, J. J.; Pavlovic, S.; Glisic, R.

    2002-01-01

    The one of the major contributors to personnel exposure whithin nuclear medicine laboratories is primarily now ubiquitous 99 Mo- 99m Tc generators. These generators, first available about more than forthy years ago, are now providing large quantities of 99m Tc radioactive source daily in the most laboratories, both for direct injection, as a per-technetate ion, and through the utilization of the kits for the preparation of dipherent radiopharmaceuticals. The safe and efficient utilization of technetium-99m in nuclear medicine, as other radionuclides, begin with the design, construction and operation of the 'Hot'Laboratory area, where radionuclide are stored and patient doses are prepared. Regardless of the specific physical configuration, suitable facilities need to be provided and good working practices established in order to get these principal objectives: (a) keep radiation exposure to personnel at ALARA levels; (b) prevent contamination of personnel; (c) prevent contamination of measuring instruments (including imaging devices such as gamma cameras and rectilinear scanners), and (d) prevent spread of contamination to places or persons outside the laboratory

  5. Human Portable Radiation Detection System Communications Package Evaluation

    International Nuclear Information System (INIS)

    Morgen, Gerald P.; Peterson, William W.

    2009-01-01

    Testing and valuation of the Human Portable Radiation Detection System Communications Package for the US Coast Guard. The main components of the HCP field kit are an Archer Field PC(reg s ign) and an Iridium satellite phone, along with various charging components and cables. The Archer Field PC has an Enfora Global System for Mobile/General Packet Radio System (GSM/GPRS) wireless cellular modem installed via the compact flash (CF) port. The Iridium satellite phone has a serial communication interface attached. The Archer Field PC is running Windows Mobile(reg s ign) 5.0 operating system. Included Microsoft products are Excel(reg s ign) Mobile, PowerPoint(reg s ign) Mobile, Word(reg s ign) Mobile, and Internet Explorer(reg s ign) Mobile. There is an Outlook(reg s ign) Email program that can be accessed via sending a file or the Messaging link. The Cambridge Computer Corporation vxHpc program is installed to provide a Hyperterm-like software product. vxHpc supports multiple communication protocols. An AT and T SIM card was provided for the GSM wireless cellular modem. A check with AT and T determined the SIM card was not activated to provide cellular service. The Iridium satellite phone did not have a SIM card and has no service. The Archer Field PC boots into a HCP program, displaying the Main Menu. The following actions can be executed by selecting the appropriate box: Spectrum Download, Spectrum Transfer, and Admin Control. The Spectrum Download function uses the serial communication port to download data files from another device, such as a Radiation Isotope Identification Device (RIID). The Spectrum Transfer function uses either the installed wireless cellular modem or the Iridium satellite phone (attached to the serial communication port) to send data files to a computer modem at the Laboratories and Scientific Services (LSS). The Admin Control function allows entering phone numbers and data file deletion. PNNL recommends that DNDO (and/or CG) contact Sanmina

  6. A radiation-hardened two transistor memory cell for monolithic active pixel sensors in STAR experiment

    International Nuclear Information System (INIS)

    Wei, X; Dorokhov, A; Hu, Y; Gao, D

    2011-01-01

    Radiation tolerance of Monolithic Active Pixel Sensors (MAPS) is dramatically decreased when intellectual property (IP) memories are integrated for fast readout application. This paper presents a new solution to improve radiation hardness and avoid latch-up for memory cell design. The tradeoffs among radiation tolerance, area and speed are significantly considered and analyzed. The cell designed in 0.35 μm process satisfies the radiation tolerance requirements of STAR experiment. The cell size is 4.55 x 5.45 μm 2 . This cell is smaller than the IP memory cell based on the same process and is only 26% of a radiation tolerant 6T SRAM cell used in previous contribution. The write access time of the cell is less than 2 ns, while the read access time is 80 ns.

  7. Human radiation studies: Remembering the early years. Oral history of Donner Lab Administrator Baird G. Whaley, August 15, 1994

    International Nuclear Information System (INIS)

    1995-09-01

    Baird G. Whaley, Donner Lab Administrator, was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE). The purpose of the interview was to capture the remembrances of Mr. Whaley concerning what he could relate on activities at the Donner Lab that pertain to the OHRE responsibilities. Following a brief biographical sketch, Mr. Whaley relates his experiences in administration at the LAB including funding activities, staffing concerns, intralaboraory politics, and remembrances of John Lawrence, John Gofman, Cornelius Tobias, Jim Born, Alex Margolis, B.V.A. Low- Beer, and Ed Alpen. Further patient care procedures for Donner Clinic Research Programs were discussed

  8. Human radiation studies: Remembering the early years. Oral history of Donner Lab Administrator Baird G. Whaley, August 15, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    Baird G. Whaley, Donner Lab Administrator, was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE). The purpose of the interview was to capture the remembrances of Mr. Whaley concerning what he could relate on activities at the Donner Lab that pertain to the OHRE responsibilities. Following a brief biographical sketch, Mr. Whaley relates his experiences in administration at the LAB including funding activities, staffing concerns, intralaboraory politics, and remembrances of John Lawrence, John Gofman, Cornelius Tobias, Jim Born, Alex Margolis, B.V.A. Low- Beer, and Ed Alpen. Further patient care procedures for Donner Clinic Research Programs were discussed.

  9. Background of external γ radiation in the proportional counters of the SAGE experiment

    International Nuclear Information System (INIS)

    Gavrin, V.N.; Gorbachev, V.V.

    2003-01-01

    The effect of external γ radiation on the process of counting 71 Ge decays in the proportional counters of the SAGE experiment measuring the solar-neutrino flux is considered. The systematic uncertainty in the SAGE result due to radon decays inside the air volume surrounding the counters is estimated. The background counting rate in the proportional counters that is caused by γ radiation from the enclosing shield is also determined

  10. Comparison between cytogenetic damage induced in human lymphocytes by environmental chemicals or radiation

    Energy Technology Data Exchange (ETDEWEB)

    Cebulska-Wasilewska, A. [Institute of Nuclear Physics, Cracow (Poland)

    1997-12-31

    Author compared cytogenetic effects of chemicals (benzene and the member at benzene related compounds) and ionizing radiation on the human lymphocytes. Levels of various types of cytogenetic damage observed among people from petroleum plants workers groups are similar to the levels of damages detected in the blood of people suspected of the accidental exposure to a radiation source

  11. Comparison between cytogenetic damage induced in human lymphocytes by environmental chemicals or radiation

    International Nuclear Information System (INIS)

    Cebulska-Wasilewska, A.

    1997-01-01

    Author compared cytogenetic effects of chemicals (benzene and the member at benzene related compounds) and ionizing radiation on the human lymphocytes. Levels of various types of cytogenetic damage observed among people from petroleum plants workers groups are similar to the levels of damages detected in the blood of people suspected of the accidental exposure to a radiation source

  12. Gene expression signatures that predict radiation exposure in mice and humans.

    Directory of Open Access Journals (Sweden)

    Holly K Dressman

    2007-04-01

    Full Text Available The capacity to assess environmental inputs to biological phenotypes is limited by methods that can accurately and quantitatively measure these contributions. One such example can be seen in the context of exposure to ionizing radiation.We have made use of gene expression analysis of peripheral blood (PB mononuclear cells to develop expression profiles that accurately reflect prior radiation exposure. We demonstrate that expression profiles can be developed that not only predict radiation exposure in mice but also distinguish the level of radiation exposure, ranging from 50 cGy to 1,000 cGy. Likewise, a molecular signature of radiation response developed solely from irradiated human patient samples can predict and distinguish irradiated human PB samples from nonirradiated samples with an accuracy of 90%, sensitivity of 85%, and specificity of 94%. We further demonstrate that a radiation profile developed in the mouse can correctly distinguish PB samples from irradiated and nonirradiated human patients with an accuracy of 77%, sensitivity of 82%, and specificity of 75%. Taken together, these data demonstrate that molecular profiles can be generated that are highly predictive of different levels of radiation exposure in mice and humans.We suggest that this approach, with additional refinement, could provide a method to assess the effects of various environmental inputs into biological phenotypes as well as providing a more practical application of a rapid molecular screening test for the diagnosis of radiation exposure.

  13. A Nonhuman Primate Model of Human Radiation-Induced Venocclusive Liver Disease and Hepatocyte Injury

    Energy Technology Data Exchange (ETDEWEB)

    Yannam, Govardhana Rao [Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska (United States); Han, Bing [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi' an Jiaotong University, Xi' an, Shaanxi (China); Setoyama, Kentaro [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Yamamoto, Toshiyuki [Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska (United States); Ito, Ryotaro; Brooks, Jenna M. [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Guzman-Lepe, Jorge [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Department of Pathology, Children' s Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States); Galambos, Csaba [Department of Pathology, Children' s Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States); Fong, Jason V. [Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Deutsch, Melvin; Quader, Mubina A. [Department of Radiation Oncology, Children' s Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States); Yamanouchi, Kosho [Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York (United States); Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York (United States); Kabarriti, Rafi; Mehta, Keyur [Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York (United States); Soto-Gutierrez, Alejandro [Department of Pathology, Children' s Hospital of Pittsburgh, Pittsburgh, Pennsylvania (United States); McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); and others

    2014-02-01

    Background: Human liver has an unusual sensitivity to radiation that limits its use in cancer therapy or in preconditioning for hepatocyte transplantation. Because the characteristic veno-occlusive lesions of radiation-induced liver disease do not occur in rodents, there has been no experimental model to investigate the limits of safe radiation therapy or explore the pathogenesis of hepatic veno-occlusive disease. Methods and Materials: We performed a dose-escalation study in a primate, the cynomolgus monkey, using hypofractionated stereotactic body radiotherapy in 13 animals. Results: At doses ≥40 Gy, animals developed a systemic syndrome resembling human radiation-induced liver disease, consisting of decreased albumin, elevated alkaline phosphatase, loss of appetite, ascites, and normal bilirubin. Higher radiation doses were lethal, causing severe disease that required euthanasia approximately 10 weeks after radiation. Even at lower doses in which radiation-induced liver disease was mild or nonexistent, latent and significant injury to hepatocytes was demonstrated by asialoglycoprotein-mediated functional imaging. These monkeys developed hepatic failure with encephalopathy when they received parenteral nutrition containing high concentrations of glucose. Histologically, livers showed central obstruction via an unusual intimal swelling that progressed to central fibrosis. Conclusions: The cynomolgus monkey, as the first animal model of human veno-occlusive radiation-induced liver disease, provides a resource for characterizing the early changes and pathogenesis of venocclusion, for establishing nonlethal therapeutic dosages, and for examining experimental therapies to minimize radiation injury.

  14. A Nonhuman Primate Model of Human Radiation-Induced Venocclusive Liver Disease and Hepatocyte Injury

    International Nuclear Information System (INIS)

    Yannam, Govardhana Rao; Han, Bing; Setoyama, Kentaro; Yamamoto, Toshiyuki; Ito, Ryotaro; Brooks, Jenna M.; Guzman-Lepe, Jorge; Galambos, Csaba; Fong, Jason V.; Deutsch, Melvin; Quader, Mubina A.; Yamanouchi, Kosho; Kabarriti, Rafi; Mehta, Keyur; Soto-Gutierrez, Alejandro

    2014-01-01

    Background: Human liver has an unusual sensitivity to radiation that limits its use in cancer therapy or in preconditioning for hepatocyte transplantation. Because the characteristic veno-occlusive lesions of radiation-induced liver disease do not occur in rodents, there has been no experimental model to investigate the limits of safe radiation therapy or explore the pathogenesis of hepatic veno-occlusive disease. Methods and Materials: We performed a dose-escalation study in a primate, the cynomolgus monkey, using hypofractionated stereotactic body radiotherapy in 13 animals. Results: At doses ≥40 Gy, animals developed a systemic syndrome resembling human radiation-induced liver disease, consisting of decreased albumin, elevated alkaline phosphatase, loss of appetite, ascites, and normal bilirubin. Higher radiation doses were lethal, causing severe disease that required euthanasia approximately 10 weeks after radiation. Even at lower doses in which radiation-induced liver disease was mild or nonexistent, latent and significant injury to hepatocytes was demonstrated by asialoglycoprotein-mediated functional imaging. These monkeys developed hepatic failure with encephalopathy when they received parenteral nutrition containing high concentrations of glucose. Histologically, livers showed central obstruction via an unusual intimal swelling that progressed to central fibrosis. Conclusions: The cynomolgus monkey, as the first animal model of human veno-occlusive radiation-induced liver disease, provides a resource for characterizing the early changes and pathogenesis of venocclusion, for establishing nonlethal therapeutic dosages, and for examining experimental therapies to minimize radiation injury

  15. Human radiation studies: Remembering the early years. Oral history of Oncologist Helen Vodopick, M.D., December 28, 1994

    International Nuclear Information System (INIS)

    1995-08-01

    This report is a transcript of an interview with Dr. Helen Vodopick by representatives of the US DOE Office of Human Radiation Experiments. Dr. Vodopick was chosen for this interview because of her involvement with the Oak Ridge Institute of Nuclear Studies (ORINS) and Oak Ridge Associated Universities (ORAU) experimental cancer-therapy program involving total-body irradiation. After a short biographical sketch Dr. Vodopick relates her remembrances of the Medium-Exposure-Rate Total Body Irradiator (METBI), ORINS radioisotope tracer studies, treatment of cancer patients with the METBI, radiation treatment for leukemia patients, bone marrow treatment of leukemia, the Low-Exposure-Rate Total Body Irradiation (LETBI), treatment of radiation accident victims at ORAU, research with radioactive phosphorus and sulfur, and public opinion issues

  16. An examination of human factors in external beam radiation therapy: Findings and implications

    International Nuclear Information System (INIS)

    Henriksen, K.; Kaye, R.D.; Jones, R.E. Jr.; Morisseau, D.S.; Persensky, J.J.

    1994-01-01

    To better understand the contributing factors to human error in external beam radiation therapy, the US Nuclear Regulatory Commission has undertaken a series of human factors evaluations. A team of human factors specialists, assisted by a panel of radiation oncologists, medical physicists, and radiation technologists, conducted visits to 24 radiation oncology departments at community hospitals, university centers, and free-standing clinics. A function and task analysis was initially performed to guide subsequent evaluations in the areas of human-system interfaces, procedures, training and qualifications, and organizational policies and practices. Representative findings and implications for improvement are discussed within the context of a dynamic model which holds that misadministration likely results from the unanticipated interaction of several necessary but singly insufficient conditions

  17. Effects of radiation and porphyrin on mitosis and chromosomes in human hematopoietic cell lines

    International Nuclear Information System (INIS)

    Tan, J.C.; Huang, C.C.; Fiel, R.J.

    1976-01-01

    The effect on mitosis of a human hematopoietic cell line RPMI-1788 treated with a metal chelate (Zn ++ ) of meso-tetra (p-carboxyphenyl) porphine (Zn-TCPP) alone at various concentrations or in combination with gamma-irradiation at various doses were studied. The results showed that both Zn-TCPP and radiation were effective in interfering with normal mitosis and that the effect of radiation was relatively more effective. Data also suggest interacting effects between Zn-TCPP and gamma-irradiation. At low doses of radiation, Zn-TCPP potentiated the effect of radiation. The reverse seemed to be true at a high dose of radiation. The effects of two porphyrins (Zn-TCPP and hematoporphyrin) and radiation on chromosomes were also studied. Chromosomal aberrations characteristic of radiation were observed. The porphyrins were found not to be effective chromosome-breaking agents under the experimental conditions tested

  18. Confronting actual influence of radiation on human bodies and biological defense mechanism

    International Nuclear Information System (INIS)

    Matsubara, Junko

    2012-01-01

    After the accident at Fukushima Daiichi Nuclear Power Plant of Tokyo Electric Power Company, social, economical, psychological pressures on local residents and fears of radiation among the general public have not been resolved. Based on the assumption that the negligence of specialists to clearly explain the influence of radiation on human bodies to the general public is the factor for above mentioned pressures and fears, the influence of radiation from a realistic view was discussed. The topics covered are: (1) understanding the meaning of radiation regulation, (2) radiation and threshold values, (3) actual influence of low-dose radiation, (4) chemical and biological defense in defense mechanism against radiation, (5) problems raised by Fukushima Daiichi nuclear accident. Furthermore, the article explains the principles and the applications of biological defense function activation, and suggested that self-help efforts to fight against stress are from now on. (S.K.)

  19. The SCID-hu mouse and its application to human radiation biology

    International Nuclear Information System (INIS)

    Kyoizumi, Seishi; Akiyama, Mitoshi; McCune, J.M.; Namikawa, Reiko.

    1993-01-01

    The radiobiological study of humans has been hampered by a lack of suitable in vivo experimental models. Of course, acute and chronic radiation effects in humans have been documented in the studies of atomic bomb (A-bomb) survivors and patients irradiated either by therapeutic intent or by accident. However, the information gained from these studies has been limited by the difficulties in estimating precise radiation doses and in obtaining biological samples for directly analyzing the processes of radiation-induced pathogenesis. With these issues in mind, we propose that the severe combined immunodeficient mouse-human chimera can be used as an in vivo experimental model for human radiation biology. We have developed techniques by which normal human bone marrow can be implanted into immunodeficient C.B-17 scid/scid (SCID) mice (S. Kyoizumi et al, Blood 79, 1704, 1992). We have report that this in vivo model can be used for the analysis of radiation damage to human bone marrow. After whole-body irradiation of the engrafted animals, human progenitor cells within the human marrow were destroyed in a dose-dependent manner (D 0 = 0.7-1.0Gy, n = 1.0). Acute hematotoxicity was reduced when the radioprotective agent (WR-2721) was administered prior to irradiation. After low dose irradiation, the recovery of human progenitor activity was accelerated by treatment with human granulocyte-colony stimulating factor (G-CSF). This small animal model may prove amenable for the risk analysis of human radiation exposure as well as for the development of new modalities for the prevention and treatment of radiotoxic damage to the human hematopoietic system. (author)

  20. Lessons learned using different mouse models during space radiation-induced lung tumorigenesis experiments.

    Science.gov (United States)

    Wang, Jian; Zhang, Xiangming; Wang, Ping; Wang, Xiang; Farris, Alton B; Wang, Ya

    2016-06-01

    Unlike terrestrial ionizing radiation, space radiation, especially galactic cosmic rays (GCR), contains high energy charged (HZE) particles with high linear energy transfer (LET). Due to a lack of epidemiologic data for high-LET radiation exposure, it is highly uncertain how high the carcinogenesis risk is for astronauts following exposure to space radiation during space missions. Therefore, using mouse models is necessary to evaluate the risk of space radiation-induced tumorigenesis; however, which mouse model is better for these studies remains uncertain. Since lung tumorigenesis is the leading cause of cancer death among both men and women, and low-LET radiation exposure increases human lung carcinogenesis, evaluating space radiation-induced lung tumorigenesis is critical to enable safe Mars missions. Here, by comparing lung tumorigenesis obtained from different mouse strains, as well as miR-21 in lung tissue/tumors and serum, we believe that wild type mice with a low spontaneous tumorigenesis background are ideal for evaluating the risk of space radiation-induced lung tumorigenesis, and circulating miR-21 from such mice model might be used as a biomarker for predicting the risk. Copyright © 2016 The Committee on Space Research (COSPAR). Published by Elsevier Ltd. All rights reserved.

  1. Lessons learned using different mouse models during space radiation-induced lung tumorigenesis experiments

    Science.gov (United States)

    Wang, Jian; Zhang, Xiangming; Wang, Ping; Wang, Xiang; Farris, Alton B.; Wang, Ya

    2016-06-01

    Unlike terrestrial ionizing radiation, space radiation, especially galactic cosmic rays (GCR), contains high energy charged (HZE) particles with high linear energy transfer (LET). Due to a lack of epidemiologic data for high-LET radiation exposure, it is highly uncertain how high the carcinogenesis risk is for astronauts following exposure to space radiation during space missions. Therefore, using mouse models is necessary to evaluate the risk of space radiation-induced tumorigenesis; however, which mouse model is better for these studies remains uncertain. Since lung tumorigenesis is the leading cause of cancer death among both men and women, and low-LET radiation exposure increases human lung carcinogenesis, evaluating space radiation-induced lung tumorigenesis is critical to enable safe Mars missions. Here, by comparing lung tumorigenesis obtained from different mouse strains, as well as miR-21 in lung tissue/tumors and serum, we believe that wild type mice with a low spontaneous tumorigenesis background are ideal for evaluating the risk of space radiation-induced lung tumorigenesis, and circulating miR-21 from such mice model might be used as a biomarker for predicting the risk.

  2. Effects of A-bomb radiation on the human body

    International Nuclear Information System (INIS)

    Shigematsu, Itsuzo; Akiyama, Mitoshi; Sasaki, Hideo; Ito, Chikato; Kamada, Nanao

    1992-01-01

    This publication consists of contributions by 39 authors in Hiroshima who are active in the forefront of research, diagnosis and treatment concerning atomic bomb survivors. Following a brief description on the damage of the atomic bomb, the subjects of malignant tumors, endocrine and metabolic diseases, ocular lesions, dermatologic effects, prenatal exposure, chromosomal aberrations, mutations, sensitivity to radiation, immune function, genetic effects and other effects of radiation are described. All of the 45 chapters are indexed individually. (J.P.N.)

  3. Effects of Ultraviolet Radiation on Human Health (invited paper)

    International Nuclear Information System (INIS)

    MacKie, R.M.

    2000-01-01

    The detrimental and beneficial effects of exposure to ultraviolet radiation in the UVB and UVA ranges are discussed. The main benefit of UV radiation is promoting the synthesis of vitamin D from precursors in the skin. Detrimental effects include acute sun damage in the form of sunburn and chronic sun damage leading to photoageing and possibly to cutaneous malignancies. Other detrimental effects of UV exposure include photosensitivity reactions to ingested drugs and rare examples of genetically determined photosensitivies. (author)

  4. Effects of Ultraviolet Radiation on Human Health (invited paper)

    Energy Technology Data Exchange (ETDEWEB)

    MacKie, R.M

    2000-07-01

    The detrimental and beneficial effects of exposure to ultraviolet radiation in the UVB and UVA ranges are discussed. The main benefit of UV radiation is promoting the synthesis of vitamin D from precursors in the skin. Detrimental effects include acute sun damage in the form of sunburn and chronic sun damage leading to photoageing and possibly to cutaneous malignancies. Other detrimental effects of UV exposure include photosensitivity reactions to ingested drugs and rare examples of genetically determined photosensitivies. (author)

  5. Jagiellonian University Radiation Damage in Silicon Particle Detectors in High Luminosity Experiments

    CERN Document Server

    Oblakowska-Mucha, A

    2017-01-01

    Radiation damage is nowadays the most serious problem in silicon particle detectors placed in the very harsh radiation environment. This problem will be even more pronounced after the LHC Upgrade because of extremely strong particle fluences never encountered before. In this review, a few aspects of radiation damage in silicon trackers are presented. Among them, the change in the silicon lattice and its influence on the detector performance are discussed. Currently applied solutions and the new ideas for future experiments will be also shown. Most of the results presented in this summary were obtained within the RD50 Collaboration

  6. Making ionising radiation a real experience for high school science students

    International Nuclear Information System (INIS)

    Whitlock, J.; Lang, P.; De La Matter, D.; Hinman, P.; White, B.

    2009-01-01

    The Canadian public has little understanding of ionising radiation due in part to its treatment in popular media. In principle, students learn about ionising radiation in their school science classes. Developments in science curricula are providing more education opportunities for this subject. The Canadian Nuclear Society's program for introducing real, personal experience with ionising radiation in the classroom is starting to make a difference. The demand is expected to exceed the resources of the CNS and the program is being developed to facilitate external support. This paper summarizes the need, the history of this program development, and the path forward. (author)

  7. Basic radiation protection training for nurses and paramedical personnel: Belgian experience and future perspectives

    International Nuclear Information System (INIS)

    Clarijs, T.; Coeck, M.; Van Bladel, Lodewijk; Fremout, An

    2015-01-01

    When using ionising radiation for medical diagnosis or treatment of patients, understanding of relevant radiation protection principles and issues is indispensable. In Belgium, nurses and paramedical staff are required to acquire knowledge for protecting the patient against the detrimental effects of ionising radiation by means of a vocational training course. The experience with and challenges for this training course are presented here from a lecturer's point of view, together with a proposal for a future approach that harmonises the training content, its level and quality, according to European recommended standards. (authors)

  8. First Results from the Online Radiation Dose Monitoring System in ATLAS experiment

    CERN Document Server

    Mandić, I; The ATLAS collaboration; Deliyergiyev, M; Gorišek, A; Kramberger, G; Mikuž, M; Franz, S; Hartert, J; Dawson, I; Miyagawa, P; Nicolas, L

    2011-01-01

    High radiation doses which will accumulate in components of ATLAS experiment during data taking will causes damage to detectors and readout electronics. It is therefore important to continuously monitor the doses to estimate the level of degradation caused by radiation. Online radiation monitoring system measures ionizing dose in SiO2 , displacement damage in silicon in terms of 1-MeV(Si) equivalent neutron fluence and fluence of thermal neutrons at several locations in ATLAS detector. In this paper design of the system, results of measurements and comparison of measured integrated doses and fluences with predictions from FLUKA simulation will be shown.

  9. Implications of human tissue studies for radiation protection

    International Nuclear Information System (INIS)

    Kathren, R.L.

    1988-01-01

    Through radiochemical analysis of voluntary tissue donations, the U.S. Transuranium and Uranium Registries (USTR) are gaining improved understanding of the distribution and biokinetics of actinide elements in occupationally exposed persons. Evaluation of the first two whole-body contributions to the USTR revealed an inverse proportionality between actinide concentration and bone ash. The analysis of a whole body with significant 241 Am deposition indicated a significantly shorter half-time in liver and a greater fraction resident in the skeleton than predicted by existing models. Other studies with tissues obtained at autopsy suggest that existing biokinetic models for 238 Pu and 241 Am and the currently accepted models and limits on intake, which use these models as their basis, may be inaccurately implying that revisions of existing safety standards may be necessary. Other studies of the registries are designed to evaluate in-vivo estimates of actinide deposition with those derived from postmortem tissue analysis, to compare results of animal experiments with human data, and to review histopathologic slides for tissue changes that might be attributable to exposure to transuranic elements. The implications of these recent findings and other work of the registries is discussed from the standpoint of this potential effect on biokinetic modeling, internal dose assessment, and safety standards and operational health physics practices

  10. Implications of human tissue studies for radiation protection.

    Science.gov (United States)

    Kathren, R L

    1988-08-01

    Through radiochemical analysis of voluntary tissue donations, the U.S. Transuranium and Uranium Registries (USTR) are gaining improved understanding of the distribution and biokinetics of actinide elements in occupationally exposed persons. Evaluation of the first two whole-body contributions to the USTR revealed an inverse proportionality between actinide concentration and bone ash. The analysis of a whole body with significant 241Am deposition indicated a significantly shorter half-time in liver and a greater fraction resident in the skeleton than predicted by existing models. Other studies with tissues obtained at autopsy suggest that existing biokinetic models for 238Pu and 241Am and the currently accepted models and limits on intake, which use these models as their basis, may be inaccurately implying that revisions of existing safety standards may be necessary. Other studies of the registries are designed to evaluate in-vivo estimates of actinide deposition with those derived from postmortem tissue analysis, to compare results of animal experiments with human data, and to review histopathologic slides for tissue changes that might be attributable to exposure to transuranic elements. The implications of these recent findings and other work of the registries is discussed from the standpoint of this potential effect on biokinetic modeling, internal dose assessment, and safety standards and operational health physics practices.

  11. Radiation, its biological effects and uses: past experiences and future perspectives

    International Nuclear Information System (INIS)

    Bharti, Neha; Pande, Nivedita

    2012-01-01

    Radiation refers to electromagnetic energy that travels through space in the form of particles or waves. It is energy such as heat, light, sound, radio waves and radar. It is everywhere including in the food we eat and the air that we breathe. Biological effects of radiation including cell killing, mutagenesis and carcinogenesis are all due to damage to DNA; Radiation releases OH ions from water molecules, which cause the cell damage due to their oxidizing effect. The mechanism by which radiation causes damage to human tissue, or any other material, is by ionization of atoms in the material. Genetic or heritable effects appear in the future generations of the exposed person as a result of radiation damage to the reproductive cells. Radiation may alter the DNA within any cell. Cell damage and death that result from mutations in somatic cells occur only in the organism in which the mutation occurred and are therefore termed somatic or no heritable effects. Acute radiation dose is defined as a large dose delivered during a short period of time. Genetic or heritable effects appear in the future generations of the exposed person as a result of radiation damage to the reproductive cells. The radiation used for cancer treatment may come from a machine outside the body, or it may come from radioactive material placed in the body near tumor cells or injected into the bloodstream. Radiation is used to help remove toxic pollutants, such as exhaust gases from coal-fired power stations and industry. For example, electron beam radiation can remove dangerous sulphur dioxides and nitrogen oxides from our environment and used to help remove toxic pollutants, such as exhaust gases from coal-fired power stations and industry. (author)

  12. DNA from radiation resistant human tumor cells transfers resistance to NIH/3T3 cells with varying degrees of penetrance

    International Nuclear Information System (INIS)

    Kasid, U.; Dritschilo, A.; Weichselbaum, R.

    1987-01-01

    Experimental evidence suggests that clinical radiation resistance may correlate with in vitro radiation survival parameters. Specifically, they isolated several cell lines from radioresistant head and neck carcinomas with D/sub 0/ values greater than 2 Gy. The authors co-transfected DNA from cell line SQ2OB (D/sub 0/ = 2.4 Gy) with the rhoSVNeO plasmid into NIH/3T3 cells (D/sub 0/ = 1.7 Gy). Antibiotic G418 resistant, transformed clones were isolated and confirmed by Southern blotting to contain human alu, as well as rhoSVNeO sequences. Screening for radiation resistance with 8Gy (Cs-137) revealed that 3 of 4 tested hybrid clones show a radiation survival intermediate between NIH/3T3 and SQ2OB. This suggests that radiation resistance is a dominant, transfectable phenotype of mammalian cells and can be expressed in more sensitive cells. Karyotyping of resistant hybrid clones shows the presence of double minute chromosomes. Secondary transfection results and experiments to clone the genetic factors responsible for radiation resistance are in progress and results will be reported

  13. Effects of Chronic Low-Dose Radiation on Human Neural Progenitor Cells

    Science.gov (United States)

    Katsura, Mari; Cyou-Nakamine, Hiromasa; Zen, Qin; Zen, Yang; Nansai, Hiroko; Amagasa, Shota; Kanki, Yasuharu; Inoue, Tsuyoshi; Kaneki, Kiyomi; Taguchi, Akashi; Kobayashi, Mika; Kaji, Toshiyuki; Kodama, Tatsuhiko; Miyagawa, Kiyoshi; Wada, Youichiro; Akimitsu, Nobuyoshi; Sone, Hideko

    2016-01-01

    The effects of chronic low-dose radiation on human health have not been well established. Recent studies have revealed that neural progenitor cells are present not only in the fetal brain but also in the adult brain. Since immature cells are generally more radiosensitive, here we investigated the effects of chronic low-dose radiation on cultured human neural progenitor cells (hNPCs) derived from embryonic stem cells. Radiation at low doses of 31, 124 and 496 mGy per 72 h was administered to hNPCs. The effects were estimated by gene expression profiling with microarray analysis as well as morphological analysis. Gene expression was dose-dependently changed by radiation. By thirty-one mGy of radiation, inflammatory pathways involving interferon signaling and cell junctions were altered. DNA repair and cell adhesion molecules were affected by 124 mGy of radiation while DNA synthesis, apoptosis, metabolism, and neural differentiation were all affected by 496 mGy of radiation. These in vitro results suggest that 496 mGy radiation affects the development of neuronal progenitor cells while altered gene expression was observed at a radiation dose lower than 100 mGy. This study would contribute to the elucidation of the clinical and subclinical phenotypes of impaired neuronal development induced by chronic low-dose radiation.

  14. Uterus transplantation: Experimental animal models and recent experience in humans

    Directory of Open Access Journals (Sweden)

    Sadık Şahin

    2015-03-01

    Full Text Available Uterus transplantation has been considered as an alternative management modality in the last few years for adoption or gestational surrogacy for women with absence of uterus due to congenital or acquired reasons. Surrogacy is legal in only a few countries because of ethical, social and legal issues. Up to date, a total of 11 uterus transplantation cases have been reported in which uteri were harvested from ten live donors and one donor with brain death. After unsuccessful attempt of first uterus transplantation, many studies have been conducted in animals and these experimental models enabled our knowledge to increase on this topic. First experimental studies were performed in rodents; later uterus transplantation was accomplished in sheep, pigs and rabbits. Recently, researches in non-human primates have led the experience regarding transplantation technique and success to improve. In this review, we reviewed the experimental animal researches in the area of uterus transplantation and recent experience in humans.

  15. Performance of Radiation Hard Pixel Sensors for the CMS Experiment

    CERN Document Server

    Dorokhov, Andrei

    2005-01-01

    Position sensitive detectors in particle physics experiments are used for the detection of the particles trajectory produced in high energy collisions. To study physics phenomena at high energies the high particle interaction rate is unavoidable, as the number of interesting events falls with the energy and the total number of events is dominated by the soft processes. The position resolution of vertex detectors has to be of few microns in order to distinguish between particle tracks produced in b-quark or tau-decays, because of the short flight path before the decay. The high spatial position resolution and the ability to detect a large number of superimposed track are the key features for tracking detectors. Modern silicon microstrip and pixel detectors with high resolution are currently most suitable devices for the tracking systems of high energy physics experiments. In this work the performance of the sensors designed for the CMS pixel detector are studied and the position resolution is estimated. In the...

  16. The `Chocolate Experiment' - A Demonstration of Radiation Absorption by Different Colored Surfaces

    Science.gov (United States)

    Fung, Dennis

    2015-12-01

    In the typical "cookbook" experiment comparing the radiation absorption rates of different colored surfaces, students' hands are commonly used as a measurement instrument to demonstrate that dull black and silvery surfaces are good and poor absorbers of radiation, respectively. However, college students are often skeptical about using their bare hands in this experiment because they learned in early science lessons that skin is not a reliable detector of heat transfer. Moreover, when the experiment is conducted in a school laboratory, it is often difficult for students to perceive the slight differences in heat transfer on the dull black and silvery aluminum leaves attached to their hands. Rather than replacing students' bare hands with such sophisticated apparatus as a data logger and temperature probe, I suggest using a simple (and delicious!) low-cost instrument, i.e., chocolate, which simply melts when it receives radiation.

  17. SHERLOCK: Simple Human Experiments Regarding Locally Observed Collective Knowledge

    Science.gov (United States)

    2015-12-01

    Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to... aware approach in coalition decision making at or near the network edge. The studies, named SHERLOCK (for Simple Human Experiments Regarding Locally...character’s location, shirt colour , preferred fruit, and hobby — are discoverable by visiting a set of locations around a university building. In

  18. Methods of computer experiment in gamma-radiation technologies using new radiation sources

    CERN Document Server

    Bratchenko, M I; Rozhkov, V V

    2001-01-01

    Presented id the methodology of computer modeling application for physical substantiation of new irradiation technologies and irradiators design work flow. Modeling tasks for irradiation technologies are structured along with computerized methods of their solution and appropriate types of software. Comparative analysis of available packages for Monte-Carlo modeling of electromagnetic processes in media is done concerning their application to irradiation technologies problems. The results of codes approbation and preliminary data on gamma-radiation absorbed dose distributions for nuclides of conventional sources and prospective Europium-based gamma-sources are presented.

  19. Production of iridium-192 radiation sources: Indian Experience

    International Nuclear Information System (INIS)

    Sastry, K.V.S.; Kolhe, O.T.; Nagarja, P.S.; Paramr, Y.D.

    2002-01-01

    Board of Radiation and Isotope Technology (BRIT), a unit under the Department of Atomic Energy is fabricating and supplying Ir-192 industrial radiography sources for various models of radiography cameras for use in the industry for non-destructive testing. Basically these sources are fabricated by encapsulating the required quantity of the activity in stainless steel 316 L capsules using Tungsten Inert gas welding process and crimping/attaching to the respective pigtail assemblies of the radiography cameras. The inactive iridium pellets are irradiated in the DHRUVA reactor at a flux on 1.8 X 10 14 n/cm 2 /sec. The performance classification of these source encapsulation for various conditions of normal and accidental nature are tested by subjecting the prototype sources as per the standard laid down by the regulatory authority, Atomic Energy Regulatory Board, in India. The sources are fabricated as per the national and international standards. Activity of the sources varies from 37O GBq (10 Ci ) to 2.96 TBq (80 Ci ) source strength depending on the requirement of the user. The specific activity of the Ir-192 sources supplied is around 7.4 TBq/gm (200 Ci/gm ). Quality control /Assurance for the manufacture of the source begins from the procurement of the raw material and ends with the finished source. Ir- 192 in the form of -0.3 mm diameter (0.1 mm dia wire of Ir-25 % and Pt-75% sheathed in pure platinum of 0.1 mm thick) is being supplied for use in the treatment of cancer of cervix, tongue etc. by brachytherapy. This is supplied in lengths of 50 cm / 100 cm with 37 - 185 GBq/cm ( 1-5 mCi/cm) activity. Annually 925 TBq (25 kCi) of Ir-192 for industrial radiography and about 60 meters of wire for brachytherapy are being fabricated and supplied. Because of the quality of these sources BRIT not only caters to the Indian industry but also is able to export sources to the third world countries. (Author)

  20. Analysis of the experience of providing radiation protection of population and environment within the international collaboration network

    International Nuclear Information System (INIS)

    Sergei Aleksanin; Eugene Zheleznyakov; Regina Fedortseva

    2007-01-01

    Complete text of publication follows. The All-Russian Center of Emergency and Radiation Medicine (ARCERM) in St. Petersburg is a specialized radiation health institution and World Health Organization (WHO) collaborating center within the Radiation Emergency Medical Preparedness and Assistance Network (REMPAN), which primary objectives are: - To promote medical preparedness for radiation accidents and radio-nuclear threats among WHO Member States; - To provide medical and public health advice, assistance and coordination of medical management at international and regional levels in the case of a nuclear accident or radiological emergency; - To assist in follow-up studies and rehabilitation. ARCERM serves as a national focal point for advice and possible medical care in cases of radiation injuries in humans as well as assists WHO to prepare relevant documents and guidelines, provides training in radiation medicine, distributes relevant information to the medical community and the public and carries out scientific investigations on radiation effects on humans. The Center is prepared to undertake actions on medical management of possible radiation emergencies both on national and international level as a member of REMPAN network. The assistance provided by ARCERM may also include providing radiation medicine and other appropriate specialists, scientific services and expertise, equipment and medical services for diagnosis, prognosis, medical treatment and medical follow-up of persons affected by radiation. In case of radiation accident the Center has standard operating procedures at country level. It includes the system of warning and data collection, setting up special wards for receiving radiation victims, radioactivity control station, primary deactivation and treatment as well as providing personal protection for staff. WHO, as well as other co-operating international organizations, are notified and provided with relevant information through the International Atomic

  1. The Ways of Advanced Human Capital: Discussions from Experiences

    Directory of Open Access Journals (Sweden)

    Rayén Amanda Rovira Rubio

    2015-11-01

    Full Text Available The present research aimed to know the significance of academic training experienced by postgraduate students who are pursuing their studies abroad under the context of a Training Program for Advanced Human Capital promoted by the Government of Chile. A feminist epistemology of situated knowledge was used as methodological framework, and narrative productions were used as technique of data collection. With this approach, the experiences of seven graduate students in Spanish universities, mostly of them beneficiaries of scholarships from Chile, were analyzed. The main findings were: the positive assessment of the experience of studying abroad, the divergent testimonies about these experiences, which based on previous educational trajectories and the socioeconomic level of the professional. These aspects influenced the identifications with the concept of Advanced Human Capital for Chile. Also, for some participants, the Advanced Human Capital is seen as an imposed concept which does not coincide with the real opportunities for the professional practice in the country. Therefore, the participants are sceptical about the possibilities of adequate job insertion in the return to Chile.

  2. Human Empathy, Personality and Experience Affect the Emotion Ratings of Dog and Human Facial Expressions

    Science.gov (United States)

    Kujala, Miiamaaria V.; Somppi, Sanni; Jokela, Markus; Vainio, Outi; Parkkonen, Lauri

    2017-01-01

    Facial expressions are important for humans in communicating emotions to the conspecifics and enhancing interpersonal understanding. Many muscles producing facial expressions in humans are also found in domestic dogs, but little is known about how humans perceive dog facial expressions, and which psychological factors influence people’s perceptions. Here, we asked 34 observers to rate the valence, arousal, and the six basic emotions (happiness, sadness, surprise, disgust, fear, and anger/aggressiveness) from images of human and dog faces with Pleasant, Neutral and Threatening expressions. We investigated how the subjects’ personality (the Big Five Inventory), empathy (Interpersonal Reactivity Index) and experience of dog behavior affect the ratings of dog and human faces. Ratings of both species followed similar general patterns: human subjects classified dog facial expressions from pleasant to threatening very similarly to human facial expressions. Subjects with higher emotional empathy evaluated Threatening faces of both species as more negative in valence and higher in anger/aggressiveness. More empathetic subjects also rated the happiness of Pleasant humans but not dogs higher, and they were quicker in their valence judgments of Pleasant human, Threatening human and Threatening dog faces. Experience with dogs correlated positively with ratings of Pleasant and Neutral dog faces. Personality also had a minor effect on the ratings of Pleasant and Neutral faces in both species. The results imply that humans perceive human and dog facial expression in a similar manner, and the perception of both species is influenced by psychological factors of the evaluators. Especially empathy affects both the speed and intensity of rating dogs’ emotional facial expressions. PMID:28114335

  3. Human Empathy, Personality and Experience Affect the Emotion Ratings of Dog and Human Facial Expressions.

    Directory of Open Access Journals (Sweden)

    Miiamaaria V Kujala

    Full Text Available Facial expressions are important for humans in communicating emotions to the conspecifics and enhancing interpersonal understanding. Many muscles producing facial expressions in humans are also found in domestic dogs, but little is known about how humans perceive dog facial expressions, and which psychological factors influence people's perceptions. Here, we asked 34 observers to rate the valence, arousal, and the six basic emotions (happiness, sadness, surprise, disgust, fear, and anger/aggressiveness from images of human and dog faces with Pleasant, Neutral and Threatening expressions. We investigated how the subjects' personality (the Big Five Inventory, empathy (Interpersonal Reactivity Index and experience of dog behavior affect the ratings of dog and human faces. Ratings of both species followed similar general patterns: human subjects classified dog facial expressions from pleasant to threatening very similarly to human facial expressions. Subjects with higher emotional empathy evaluated Threatening faces of both species as more negative in valence and higher in anger/aggressiveness. More empathetic subjects also rated the happiness of Pleasant humans but not dogs higher, and they were quicker in their valence judgments of Pleasant human, Threatening human and Threatening dog faces. Experience with dogs correlated positively with ratings of Pleasant and Neutral dog faces. Personality also had a minor effect on the ratings of Pleasant and Neutral faces in both species. The results imply that humans perceive human and dog facial expression in a similar manner, and the perception of both species is influenced by psychological factors of the evaluators. Especially empathy affects both the speed and intensity of rating dogs' emotional facial expressions.

  4. Estimating the Global Agricultural Impact of Solar Radiation Management using Volcanic Eruptions as Natural Experiments

    Science.gov (United States)

    Proctor, J.; Hsiang, S. M.; Burney, J. A.; Burke, M.; Schlenker, W.

    2017-12-01

    Solar radiation management (SRM) is increasingly considered an option for managing global temperatures, yet the economic impacts of ameliorating climatic changes by scattering sunlight back to space remain largely unknown. Though SRM may increase crop yields by reducing heat stress, its impacts from concomitant changes in available sunlight have never been empirically estimated. Here we use the volcanic eruptions that inspired modern SRM proposals as natural experiments to provide the first estimates of how the stratospheric sulfate aerosols (SS) created by the eruptions of El Chichon and Pinatubo altered the quantity and quality of global sunlight, how those changes in sunlight impacted global crop yields, and the total effect that SS may have on yields in an SRM scenario when the climatic and sunlight effects are jointly considered. We find that the sunlight-mediated impact of SS on yields is negative for both C4 (maize) and C3 (soy, rice, wheat) crops. Applying our yield model to a geoengineering scenario using SS-based SRM from 2050-2069, we find that SRM damages due to scattering sunlight are roughly equal in magnitude to SRM benefits from cooling. This suggests that SRM - if deployed using SS similar to those emitted by the volcanic eruptions it seeks to mimic - would attenuate little of the damages from climate change to global agriculture on net. Our approach could be extended to study SRM impacts on other global systems, such as human health or ecosystem function.

  5. Investigation of the factors disguising radiation effects on the human body

    International Nuclear Information System (INIS)

    Korzeneva, I.B.; Styazhkina, T.V.; Dubrova, Y.E.; Malinina, T.V.; Prokhorovskaya, V.D.; Kholod, O.N.

    1998-01-01

    Herein we have studied the effects of some hereditary and environmental factors on children's states of health. The factors under investigation, along with radiation, also impact the immunological status and human adaptivity, thus disguising hazardous radiation effects. The state-of-health criterion we have chosen are children's liability to a wide range of intrinsic diseases through the first three years of life. The analysis involved 626 children (326 male and 300 female) who's parents and grandparents lived in the vicinity of the Russian Federal Nuclear Centre (RFNC), a large-scale nuclear facility. Our results should preferably be taken into consideration when projecting radiation effects on the human body. (author)

  6. Human exposure to non-ionizing radiation and potential adverse health effects

    International Nuclear Information System (INIS)

    Vulevic, B.; Maric, B.; Zivkovic, D.

    1999-01-01

    The problem of protection from the non-ionizing radiation has presented an actual subject in the last twenty years both worldwide and in our country. Great attention has been paid to this problem throughout the world and there is not almost a field of human activities that disregards the effect of non-ionizing radiation to the human health.The object of this work is to point concisely, on the basis of numerous domestic and foreign referential data, to the potential adverse health effects caused by uncontrolled exposure to non-ionizing radiation. (author)

  7. Study of terahertz-radiation-induced DNA damage in human blood leukocytes

    Energy Technology Data Exchange (ETDEWEB)

    Angeluts, A A; Esaulkov, M N; Kosareva, O G; Solyankin, P M; Shkurinov, A P [International Laser Center, M. V. Lomonosov Moscow State University, Moscow (Russian Federation); Gapeyev, A B; Pashovkin, T N [Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region (Russian Federation); Matyunin, S N [Section of Applied Problems at the Presidium of the Russian Academy of Sciences, Moscow (Russian Federation); Nazarov, M M [Institute on Laser and Information Technologies, Russian Academy of Sciences, Shatura, Moscow Region (Russian Federation); Cherkasova, O P [Institute of Laser Physics, Siberian Branch, Russian Academy of Sciences, Novosibirsk (Russian Federation)

    2014-03-28

    We have carried out the studies aimed at assessing the effect of terahertz radiation on DNA molecules in human blood leukocytes. Genotoxic testing of terahertz radiation was performed in three different oscillation regimes, the blood leukocytes from healthy donors being irradiated for 20 minutes with the mean intensity of 8 – 200 μW cm{sup -2} within the frequency range of 0.1 – 6.5 THz. Using the comet assay it is shown that in the selected regimes such radiation does not induce a direct DNA damage in viable human blood leukocytes. (biophotonics)

  8. Dosimetric evaluation of whole-breast radiation therapy: Clinical experience

    International Nuclear Information System (INIS)

    Osei, Ernest; Darko, Johnson; Fleck, Andre; White, Jana; Kiciak, Alexander; Redekop, Rachel; Gopaul, Darin

    2015-01-01

    Radiation therapy of the intact breast is the standard therapy for preventing local recurrence of early-stage breast cancer following breast conservation surgery. To improve patient standard of care, there is a need to define a consistent and transparent treatment path for all patients that reduces significance variations in the acceptability of treatment plans. There is lack of consistency among institutions or individuals about what is considered an acceptable treatment plan: target coverage vis-à-vis dose to organs at risk (OAR). Clinical trials usually resolve these issues, as the criteria for an acceptable plan within the trial (target coverage and doses to OAR) are well defined. We developed an institutional criterion for accepting breast treatment plans in 2006 after analyzing treatment data of approximately 200 patients. The purpose of this article is to report on the dosimetric review of 623 patients treated in the last 18 months to evaluate the effectiveness of the previously developed plan acceptability criteria and any possible changes necessary to further improve patient care. The mean patient age is 61.6 years (range: 25.2 to 93.0 years). The mean breast separation for all the patients is 21.0 cm (range: 12.4 to 34.9 cm), and the mean planning target volume (PTV-eval) (breast volume for evaluation) is 884.0 cm"3 (range: 73.6 to 3684.6 cm"3). Overall, 314 (50.4%) patients had the disease in the left breast and 309 (49.6%) had it in the right breast. A total of 147 (23.6%) patients were treated using the deep inspiration breath-hold (DIBH) technique. The mean normalized PTV-eval receiving at least 92% (V_9_2_% _P_D) and 95% (V_9_5_% _P_D) of the prescribed dose (PD) are more than 99% and 97%, respectively, for all patients. The mean normalized PTV-eval receiving at least 105% (V_1_0_5_% _P_D) of the PD is less than 1% for all groups. The mean homogeneity index (HI), uniformity index (UI), and conformity index (CI) for the PTV-eval are 0.09 (range: 0

  9. Enhancement of Radiation Effects by Ursolic Acid in BGC-823 Human Adenocarcinoma Gastric Cancer Cell Line.

    Directory of Open Access Journals (Sweden)

    Yang Yang

    Full Text Available Recent research has suggested that certain plant-derived polyphenols, i.e., ursolic acid (UA, which are reported to have antitumor activities, might be used to sensitize tumor cells to radiation therapy by inhibiting pathways leading to radiation therapy resistance. This experiment was designed to investigate the effects and possible mechanism of radiosensitization by UA in BGC-823 cell line from human adenocarcinoma gastric cancer in vitro. UA caused cytotoxicity in a dose-dependent manner, and we used a sub-cytotoxicity concentration of UA to test radioenhancement efficacy with UA in gastric cancer. Radiosensitivity was determined by clonogenic survival assay. Surviving fraction of the combined group with irradiation and sub-cytotoxicity UA significantly decreased compared with the irradiation group. The improved radiosensitization efficacy was associated with enhanced G2/M arrest, increased reactive oxygen species (ROS, down-regulated Ki-67 level and improved apoptosis. In conclusion, as UA demonstrated potent antiproliferation effect and synergistic effect, it could be used as a potential drug sensitizer for the application of radiotherapy.

  10. γ-radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines.

    Science.gov (United States)

    Kumar, Ashok; Rai, Padmalatha S; Upadhya, Raghavendra; Vishwanatha; Prasada, K Shama; Rao, B S Satish; Satyamoorthy, Kapettu

    2011-11-01

    Ionizing radiation induces cellular damage through both direct and indirect mechanisms, which may include effects from epigenetic changes. The purpose of this study was to determine the effect of ionizing radiation on DNA methylation patterns that may be associated with altered gene expression. Sixteen human tumor cell lines originating from various cancers were initially tested for radiation sensitivity by irradiating them with γ-radiation in vitro and subsequently, radiation sensitive and resistant cell lines were treated with different doses of a demethylating agent, 5-Aza-2'-Deoxycytidine (5-aza-dC) and a chromatin modifier, Trichostatin-A (TSA). Survival of these cell lines was measured using 3-(4, 5-Dimethylthiazol- 2-yl)-2, 5-diphenyltetrazolium (MTT) and clonogenic assays. The effect of radiation on global DNA methylation was measured using reverse phase high performance liquid chromatography (RP-HPLC). The transcription response of methylated gene promoters, from cyclin-dependent kinase inhibitor 2A (p16(INK4a)) and ataxia telangiectasia mutated (ATM) genes, to radiation was measured using a luciferase reporter assay. γ-radiation resistant (SiHa and MDAMB453) and sensitive (SaOS2 and WM115) tumor cell lines were examined for the relationship between radiation sensitivity and DNA methylation. Treatment of cells with 5-aza-dC and TSA prior to irradiation enhanced DNA strand breaks, G2/M phase arrest, apoptosis and cell death. Exposure to γ-radiation led to global demethylation in a time-dependent manner in tumor cells in relation to resistance and sensitivity to radiation with concomitant activation of p16(INK4a) and ATM gene promoters. These results provide important information on alterations in DNA methylation as one of the determinants of radiation effects, which may be associated with altered gene expression. Our results may help in delineating the mechanisms of radiation resistance in tumor cells, which can influence diagnosis, prognosis and

  11. Effects of atomic bomb radiations on human food

    Energy Technology Data Exchange (ETDEWEB)

    Pace, F C

    1956-01-01

    The increase in energy release of atomic weapons has increased the hazard of atomic radiation to food. Products of atomic explosions are probably similar regardless of size. Of the energy released, blast energy accounts for one-half, heat flash for one-third, initial nuclear radiation for one-twentieth, and residual radiation (potential fallout) about one-tenth. Radioactive elements may enter man by inhalation, by open wounds, or by ingestion of contaminated food. Food can become contaminated by direct fallout on unprotected food or through metabolic assimilation by plants or animals. Dust-proof containers and undamaged cans provide protection from the first hazard. Cans, etc. should be washed before opening. Other food could be cleaned and used if subsequent monitoring indicated that the fallout material had been removed.

  12. Reconstruction of human exposure to heavy metals using synchrotron radiation microbeams in prehistoric and modern humans

    International Nuclear Information System (INIS)

    Koizumi, Akio; Azechi, Miki; Shirasawa, Koyo

    2009-01-01

    Teeth can serve as records of environmental exposure to heavy metals during their formation. We applied a new technology - synchrotron radiation microbeams (SRXRF) - for analysis of heavy metals in human permanent teeth in modern and historical samples. Each tooth was cut in half. A longitudinal section 200 μm in thickness was subjected to the determination of the heavy metal content by SRXRF or conventional analytical methods (ICP-MS analysis or reduction-aeration atomic absorption spectrometry). The relative concentrations of Pb, Hg, Cu and Zn measured by SRXRF were translated in concentrations (in g of heavy metal/g of enamel) using calibration curves by the two analytical methods. Concentrations in teeth in the modern females (n=5) were 1.2±0.5 μg/g (n=5) for Pb; 1.7±0.2 ng/g for Hg; 0.9±1.1 μg/g for Cu; 150±24.6 μg/g for Zn. The levels of Pb were highest in the teeth samples obtained from the humans of the Edo era (1603-1868 AD) (0.5-4.0 μg/g, n=4). No trend was observed in this study in the Hg content in teeth during 3,000 years. The concentrations of Cu were highest in teeth of two medieval craftsmen (57.0 and 220 μg/g). The levels of Zn were higher in modern subjects (P<0.05) than those in the Jomon (∼1000 BC) to Edo periods [113.2±27.4 (μg/g, n=11)]. Reconstruction of developmental exposure history to lead in a famous court painter of the Edo period (18th century) revealed high levels of Pb (7.1-22.0 μg/g) in his childhood. SRXRF is useful a method for reconstructing human exposures in very long trends. (author)

  13. Effects of ozone depletion and UV-B radiation on humans and the environment

    Energy Technology Data Exchange (ETDEWEB)

    Solomon, K.R. [Guelph Univ., ON (Canada). Centre for Toxicology

    2008-03-15

    This paper summarized current research related to the effects of ultraviolet (UV-B) radiation on human health and the environment. Effects included direct responses in human as well as effects on biogeochemistry and the environmental cycling of substances. UV radiation has many harmful effects on the skin, eyes, and immune systems of humans. Skin cancer is a leading cause of death among fair-skinned populations exposed to UV radiation. The role of UV radiation in cataract formation was discussed, as well as issues related to the suppression of immune responses. The link between sunlight exposure and vitamin D levels in human populations was examined. The effects of UV radiation on terrestrial and aquatic ecosystems were reviewed. Issues related to biogeochemistry and atmospheric processes were discussed. The review suggested that changes in the intensity of solar UV radiation due to ozone depletion will have important repercussions for all organisms on the planet. It was concluded that the combined effects of UV-B radiation and climate change will not be easy to predict. 201 refs., 4 figs.

  14. New tools and technology for the study of human performance in simulator experiments

    International Nuclear Information System (INIS)

    Droeivoldsmo, Asgeir

    2004-04-01

    The Halden Virtual Reality Centre has for the last four years reported a number of experiments in the area of real world application of virtual and augmented reality technology. The insights from these studies have been reviewed and reported as part of a PhD-thesis submitted at the Norwegian University of Science and Technology. This report is based on the thesis and contains a theoretical discussion of how the virtual and augmented reality technology could be used to extend human operator performance in control rooms to include co-operation with plant floor personnel and interaction with not already built equipment. This thesis suggests that new tools and technology can be used for production of relevant data and insights from the study of human performance in simulator and field experiments. It examines some of the theoretical perspectives behind data collection and human performance assessment, and argues for a high resemblance of the real world and use of subject matter expertise in simulator studies. A model is proposed, suggesting that human performance measurement should be tightly coupled to the topic of study and have a close connection to the time line. This coupling requires new techniques for continuous data collection, and eye movement tracking has been identified as a promising basis for this type of measures. One way of improving realism is to create virtual environments allowing for controlling more of the environment surrounding the test subjects. New application areas for virtual environments are discussed for use in control room and field studies. The combination of wearable computing, virtual and augmented (the use of computers to overlay virtual information onto the real world) reality provides many new possibilities to present information to operators. In two experiments, virtual and augmented reality techniques were used to visualise radiation fields for operators in a contaminated nuclear environment. This way the operators could train for

  15. Experiences in Accreditation of Laboratories in the Field of Radiation Science

    International Nuclear Information System (INIS)

    Franic, Z.; Galjanic, S.; Krizanec, D.

    2011-01-01

    Efficient interaction of technical legislation, metrology, standardization and accreditation within the system of quality infrastructure is precondition for assurance of safety of goods and services as well as protection of humans and environment. In the paper importance of quality infrastructure on national and international levels is presented while special interest is paid to accreditation. Current situation regarding the accreditation of laboratories in the field of radiation science is presented. Regarding this field, in Croatia three laboratories are accredited by Croatian Accreditation Agency: 1. Laboratory for Radioecology, Rudjer Boskovic Institute (Scope: Measurement of radionuclide content in environmental samples and commodities - Including foodstuffs and drinking water) 2. EKOTEH Dozimetrija Ltd., Department for Radiation Protection (Scope: Testing in the scope of ionizing and nonionizing radiation) 3. Radiation Protection Unit, Institute for Medical Research and Occupational Health (Scope: Determination of radioactivity). (author)

  16. Enhanced natural radiation exposure enhanced by human activity: the largest contributor to the Chinese population dose

    International Nuclear Information System (INIS)

    Pan Ziqiang; Liu Yanyang

    2011-01-01

    For the radiation exposure caused by human activities, the enhanced natural radiation exposure is the largest contributor to Chinese population dose. This problem has attracted social attention in recent years. Efforts have been made in several fields, such as radon indoors and in workplace, environmental problems associated with NORMs, occupational radiation hazards of non-uranium mine, and radiation dose evaluation for energy chain, but there are still many problems to be solved. In order to protect the health of workers and the public, while ensuring industrial production and economic development, it is also necessary to continue to strengthen research in all aspects above mentioned, and gradually promote the control of natural radiation exposure enhanced by human activities. (authors)

  17. Clustered DNA damages induced in human hematopoietic cells by low doses of ionizing radiation

    Science.gov (United States)

    Sutherland, Betsy M.; Bennett, Paula V.; Cintron-Torres, Nela; Hada, Megumi; Trunk, John; Monteleone, Denise; Sutherland, John C.; Laval, Jacques; Stanislaus, Marisha; Gewirtz, Alan

    2002-01-01

    Ionizing radiation induces clusters of DNA damages--oxidized bases, abasic sites and strand breaks--on opposing strands within a few helical turns. Such damages have been postulated to be difficult to repair, as are double strand breaks (one type of cluster). We have shown that low doses of low and high linear energy transfer (LET) radiation induce such damage clusters in human cells. In human cells, DSB are about 30% of the total of complex damages, and the levels of DSBs and oxidized pyrimidine clusters are similar. The dose responses for cluster induction in cells can be described by a linear relationship, implying that even low doses of ionizing radiation can produce clustered damages. Studies are in progress to determine whether clusters can be produced by mechanisms other than ionizing radiation, as well as the levels of various cluster types formed by low and high LET radiation.

  18. Primary radiation therapy for early breast cancer: the experience at the joint center for radiation therapy

    International Nuclear Information System (INIS)

    Harris, J.R.; Botnick, L.; Bloomer, W.D.; Chaffey, J.T.; Hellman, S.

    1981-01-01

    The results of primary radiation therapy in 176 consecutive patients with clinical State I and II carcinoma of the breast were reviewed. Median follow-up time was 47 months. The overall breast relapse rate was 7%. Patients undergoing interstitial implantation had a significantly lower breast relapse rate (1%) than patients not undergoing implantation (11%). Breast relapse was more common in patients undergoing incisional or needle biopsy (17%), compared to patients treated after excisional biopsy (5%). In patients undergoing excisional biopsy, but not interstitial implantation, breast relapse was related to external beam dose. Twelve percent of the patients who received less than 1600 ret dose relapsed in the breast, compared to none of the 19 patients who received more than 1700 ret dose. These results imply that supplemental irradiation to the primary tumor area is required following excisional biopsy of a primary breast cancer when 4500-5000 rad is delivered to the entire breast

  19. Methodological aspects of hygienic standardization of complex radiation and non-radiation effects on human organizm

    International Nuclear Information System (INIS)

    Liberman, A.N.; Sanovskaya, M.S.; Bronshtejn, I.Eh.; Orobej, V.V.

    1978-01-01

    Considered are the necessary requirements for the methodics of substantiating the hygienic standards for a combined effect of radiation and nonradiation factors on workers engaged in electronic, radio engineering branches of industry and a number of nuclear-physical units. These approaches were used in planning and conducting of investigations on hygienic evaluation of a combined effect of ionizing radiation, electromagnetic UHF radiation, noise and other factors. Along with experimental investigations on small laboratory animals, clinico-physiological examinations of people affected by a combined or predominantely separate effect of the above-mentioned factors have been carried out for many years. The material obtaed has been subjected to mathematical treatment with the use of dispersion analysis. The results testify to the intensification of the effect under conditions of a combined action of X-ray and UHF radiations and noise

  20. Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis

    DEFF Research Database (Denmark)

    Rødningen, Olaug Kristin; Børresen-Dale, Anne-Lise; Alsner, Jan

    2008-01-01

    BACKGROUND AND PURPOSE: Breast cancer patients show a large variation in normal tissue reactions after ionizing radiation (IR) therapy. One of the most common long-term adverse effects of ionizing radiotherapy is radiation-induced fibrosis (RIF), and several attempts have been made over the last...... years to develop predictive assays for RIF. Our aim was to identify basal and radiation-induced transcriptional profiles in fibroblasts from breast cancer patients that might be related to the individual risk of RIF in these patients. MATERIALS AND METHODS: Fibroblast cell lines from 31 individuals......-treated fibroblasts. Transcriptional differences in basal and radiation-induced gene expression profiles were investigated using 15K cDNA microarrays, and results analyzed by both SAM and PAM. RESULTS: Sixty differentially expressed genes were identified by applying SAM on 10 patients with the highest risk of RIF...

  1. Radiation

    International Nuclear Information System (INIS)

    2013-01-01

    The chapter one presents the composition of matter and atomic theory; matter structure; transitions; origin of radiation; radioactivity; nuclear radiation; interactions in decay processes; radiation produced by the interaction of radiation with matter

  2. What Threats to Human Health Does Space Radiation Pose in Orbit

    Science.gov (United States)

    Wu, Honglu; Semones, Eddie; Weyland, Mark; Zapp, Neal; Cucinotta, Francis A.

    2011-01-01

    The Space Shuttle program spanned more than the entire length of a solar cycle. Investigations aimed towards understanding the health risks of the astronauts from exposures to space radiation involved mostly physical measurements of the dose and the linear energy transfer (LET) spectrum. Measurement of the dose rate on the Shuttle provided invariable new data for different periods of the solar cycle, whereas measurement of the LET spectrum using the tissue equivalent proportional counter (TEPC) produced the most complete mapping of the radiation environment of the low Earth orbits (LEO). Exposures to the Shuttle astronauts were measured by the personal dosimeter worn by the crewmembers. Analysis of over 300 personal dosimeter readings indicated a dependence on the mission duration, the altitude and inclination of the orbit, and the solar cycle, with the crewmembers on the launch and repair of the Hubble telescope receiving the highest doses due to the altitude of the mission. Secondary neutrons inside the Shuttle were determined by recoil protons or with Bonner spheres, and may contribute significantly to the risks of the crewmembers. In addition, the skin dose and the doses received at different organs were compared using a human phantom onboard a Shuttle mission. A number of radiobiology investigations wer e also performed. The biological doses were determined on six astronauts/cosmonauts on long-duration Shuttle/Mir missions and on two crewmembers on a Hubble repair mission by analyzing the damages in the chromosomes of the crewmembers? white blood cells. Several experiments were also conducted to address the question of possible synergistic effects of spaceflight, microgravity in particular, on the repair of radiation-induced DNA damages. The experimental design included exposure of cells before launch, during flight, or after landing. These physical and biological studies were invaluable in predicting the health risks for astronauts on ISS and future

  3. New tools and technology for the study of human performance in simulator experiments

    Energy Technology Data Exchange (ETDEWEB)

    Droeivoldsmo, Asgeir

    2003-07-01

    This thesis suggests that new tools and technology can be used for production of relevant data and insights from the study of human performance in simulator and field experiments. It examines some of the theoretical perspectives behind data collection and human performance assessment, and argues for a high resemblance of the real world and use of subject matter expertise in simulator studies. A model is proposed, suggesting that human performance measurement should be tightly coupled to the topic of study and have a close connection to the time line. This coupling requires new techniques for continuous data collection, and eye movement tracking has been identified as a promising basis for this type of measures. One way of improving realism is to create virtual environments allowing for controlling more of the environment surrounding the test subjects. New application areas for virtual environments are discussed for use in control room and field studies. The combination of wearable computing, virtual and augmented (the use of computers to overlay virtual information onto the real world) reality provides many new possibilities to present information to operators. In two experiments, virtual and augmented reality techniques were used to visualise radiation fields for operators in a contaminated nuclear environment. This way the operators could train for and execute their tasks in a way that minimised radiation exposure to the individual operator. Both experiments were successful in proving the concept of radiation visualisation Virtual environments allow for early end-user feedback in the design and refurbishment of control room man-machine interfaces. The practical usability of VR in the control room setting was tested in two control room design experiments. The results show that with the right tools for solving the tasks under test, even desktop presentations of the virtual environment can provide sufficient resemblance of the real world. Computerised data

  4. New tools and technology for the study of human performance in simulator experiments

    Energy Technology Data Exchange (ETDEWEB)

    Droeivoldsmo, Asgeir

    2003-07-01

    This thesis suggests that new tools and technology can be used for production of relevant data and insights from the study of human performance in simulator and field experiments. It examines some of the theoretical perspectives behind data collection and human performance assessment, and argues for a high resemblance of the real world and use of subject matter expertise in simulator studies. A model is proposed, suggesting that human performance measurement should be tightly coupled to the topic of study and have a close connection to the time line. This coupling requires new techniques for continuous data collection, and eye movement tracking has been identified as a promising basis for this type of measures. One way of improving realism is to create virtual environments allowing for controlling more of the environment surrounding the test subjects. New application areas for virtual environments are discussed for use in control room and field studies. The combination of wearable computing, virtual and augmented (the use of computers to overlay virtual information onto the real world) reality provides many new possibilities to present information to operators. In two experiments, virtual and augmented reality techniques were used to visualise radiation fields for operators in a contaminated nuclear environment. This way the operators could train for and execute their tasks in a way that minimised radiation exposure to the individual operator. Both experiments were successful in proving the concept of radiation visualisation. Virtual environments allow for early end-user feedback in the design and refurbishment of control room man-machine interfaces. The practical usability of VR in the control room setting was tested in two control room design experiments. The results show that with the right tools for solving the tasks under test, even desktop presentations of the virtual environment can provide sufficient resemblance of the real world. Computerised data

  5. Effects of recombinant human epidermal growth factor (rhEGF) on experimental radiation-induced oral mucositis in rats

    International Nuclear Information System (INIS)

    Jung, Kwon Il; Kim, Sun Hee; Moon, Soo Young; Kim, Yeon Wha; Hong, Joon Pio; Lee, Sang Wook; Kim, Hyun Sook

    2006-01-01

    Oral mucositis is a common toxicity of radiation or chemotherapy, which is used a treatment for head and neck cancer. We investigated effects of recombinant human epidermal growth factor (rhEGF) on radiation-induced oral mucositis in rat model. Spraque-Dawley rats (7 per group) exposed to a single dose of 25 Gy (day 0) on their head, except for one group, were randomly divided into un-treated, vehicle-treated, and two rhEGF-treated groups. Rats were topically applied with rhEGF (15 or 30 μ g/oral cavity/day) or vehicle to their oral mucosa. Survival rate of rats, weight changes, and food intakes were examined from day 0 to 18 after radiation. Histology study was performed from oral mucosa of rats at day 7 and 18 after radiation. rhEGF-treated groups (15 or 30 μ g/day) showed all survival rate 33%, whereas un-treated and vehicle-treated groups showed all survival rate 0% at the end of experiment. rhEGF-treated groups statistically had less weight loss compared to vehicle-treated group from day 2 to 7 after radiation. Food intake of rats with rhEGF treatment turned to increase at day 14 after radiation. At 7 day after radiation, un-treated and vehicle-treated groups showed severe pseudomembraneous of ulcerative oral mucositis. On the other hand, rhEGF-treated groups had no more than cellular swelling and degeneration of epidermal cells in oral mucosa of rats. These results suggest that rhEGF has significantly positive effects on radiation-induced oral mucositis in rats. rhEGF display a therapeutic potential on a clinical level

  6. Understanding and characterisation of the risks to human health from exposure to low levels of radiation

    International Nuclear Information System (INIS)

    Goodhead, D. T.

    2009-01-01

    Exposure to ionising radiation can lead to a wide variety of health effects. Cancer is judged to be the main risk from radiation at low doses and low dose rates, and controlling this risk has been the main factor in developing radiation protection practice. Conventional paradigms of radiobiology and radiation carcinogenesis have served to guide extrapolations of epidemiological data on exposed human populations, so as to estimate risks at low doses and low dose rates, to other types of ionising radiation and to non-uniform exposures. These paradigms are founded on a century of experimental and theoretical studies, but nevertheless there remain many uncertainties. Major assumptions and simplifications have been introduced to achieve a practical system of additive doses (and implied risks) for radiation protection. Advancing epidemiological studies and experimental research continue to reduce uncertainties in some areas while, in others, they raise new challenges to the generality and applicability of the conventional paradigms. (authors)

  7. Risks of increased UV-B radiation for humans

    International Nuclear Information System (INIS)

    Przybilla, B.; Eberlein-Koenig, B.; Bergner, T.

    1994-01-01

    If not compensated in any way, depletion of the stratospheric ozone layer leads to an increase of UV-B radiation at the earth's surface, especially towards the short-wave range, which is biologically the more active. The most concerning effect here is that of UV-B induced skin reactions, in particular malignant skintumors (malignant melanoma, spinocellular carcinoma, basalioma), whose incidence is expected to increase in future. As some photoreactions can be inhibited or enhanced also by radiation outside their action spectrum, it is possible for changes in solar spectral radiation flux density to influence photo-induced reactions that are driven at wavelengths outside the UV-B range. The authors have performed studies for developing methods of quantifying individual UV sensitivity. In vitro studies have shown that UV-A dependent photoreactions can be partly inhibited by UV-B. A number of drugs, as well as sulphites, which are used as preservatives amongst other things, have been shown to have phototoxic properties that may be relevant to photocarcinogenesis. Irradiation tests on cell cultures for different UV-B ranges have shown that irradiation at shorter wavelengths leads to a stronger release of proinflammatory cytokines that ar longer wavelengths with the same dose. Altogether it can be said that despite compelling theoretical evidence it is not easily possible to predict the actual consequences of an increase in particular of short-wave UV-B radiation at the earth's surface. The assumed effects must be examined individually by appropriate methods. (orig.) [de

  8. The secondary biogenic radiation of gamma-irradiated human blood

    International Nuclear Information System (INIS)

    Kuzin, A.M.; Surkenova, G.N.; Budagovskij, A.V.; Gudi, G.A.

    1997-01-01

    The sample of blood freshly taken from healthy men were gamma-irradiated with a dose of 10 Gy. It was shown that after the treatment the blood gained the capacity to emit secondary biogenic radiation. Emission lasted for some hours, passed through quartz-glass curette and was revealed by stimulating influence on biological detector (sprouting seeds)

  9. Radiation absorbed dose to the human fetal thyroid

    International Nuclear Information System (INIS)

    Watson, E.E.

    1992-01-01

    The embryo/fetus is recognized to be particularly susceptible to damage from exposure to radiation. Many advisory groups have studied available information concerning radiation doses and radiation effects with the goal of reducing the risk to the embryo/fetus. Of particular interest are radioactive isotopes of iodine. Radioiodine taken into the body of a pregnant woman presents a possible hazard for the embryo/fetus. The fetal thyroid begins to concentrate iodine at about 13 weeks after conception and continues to do so throughout gestation. At term, the organic iodine concentration in the fetal blood is about 75% of that in the mother's blood. This paper presents a review the models that have been proposed for the calculation of the dose to the fetal thyroid from radioisotopes of iodine taken into the body of the pregnant woman as sodium iodide. A somewhat different model has been proposed, and estimates of the radiation dose to the fetal thyroid calculated from this model are given for each month of pregnancy from 123 I , 124 I , 125 I , and 131 I

  10. Human genetic studies in areas of high natural radiation

    International Nuclear Information System (INIS)

    Freire-Maia, A.; Krieger, H.

    1978-01-01

    Data have been obtained by a genetic-epidemiological survey of a population living in the State of Espirito Santo (Brazil), and subjected to mean levels of natural radiation, per locality, ranging from 7 to 133 μrad/hr. Multiple regression models have been applied to the data, and the results showed no detectable effect of natural radiation on the sex ratio at birth, on the occurrence of congenital anomalies, and on the numbers of pregnancy terminations, stillbirths, livebirths, and post-infant mortality in the children, as well as fecundity and fertility of the couples (these observations contradict some data from the literature, based on official records and without analyses of the concomitant effects of other variables). However, nonsignificant results cannot be considered as disproving harmful effects of natural radiation on mortality and morbidity. These results may simply mean that other causes of mortality and morbidity are so important, under the conditions of the study, that the contribution of low-level, chronic natural radiation is made negligible. (author)

  11. ROS Mediates Radiation-Induced Differentiation in Human Lung Fibroblast

    International Nuclear Information System (INIS)

    Park, Sa Rah; Ahn, Ji Yeon; Kim, Mi Hyeung; Lim, Min Jin; Yun, Yeon Sook; Song, Jie Young

    2009-01-01

    One of the most common tumors worldwide is lung cancer and the number of patients with lung cancer received radiotherapy is increasing rapidly. Although radiotherapy may have lots of advantages, it can also induce serious adverse effects such as acute radiation pneumonitis and pulmonary fibrosis. Pulmonary fibrosis is characterized by excessive production of smooth muscle actin-alpha (a-SMA) and accumulation of extracellular matrix (ECM) such as collagen and fibronectin. There has been a great amount of research about fibrosis but the exact mechanism causing the reaction is not elucidated especially in radiation-induced fibrosis. Until now it has been known that several factors such as transforming growth factor (TGF-b), tumor necrosis factor (TNF), IL-6, platelet-derived growth factor (PDGF) and reactive oxygen species are related to fibrosis. It is also reported that reactive oxygen species (ROS) can be induced by radiation and can act as a second messenger in various signaling pathways. Therefore we focused on the role of ROS in radiation induced fibrosis. Here, we suggest that irradiation generate ROS mainly through NOX4, result in differentiation of lung fibroblast into myofibroblast

  12. Mathematical Models of Human Hematopoiesis Following Acute Radiation Exposure

    Science.gov (United States)

    2014-05-01

    response of 11 subjects from Chernobyl 1986 . . . . . . 104 B.8 Chernobyl case studies: Platelet data . . . . . . . . . . . . . . . . . . . . . . 105 B...9 Chernobyl case studies: Granulocyte data . . . . . . . . . . . . . . . . . . . 106 B.10 Chernobyl case studies: Lymphocyte data...information for use in nuclear disaster preparedness planning. Understanding how biological systems change after radiation exposure provides insight on the

  13. Proceedings of the workshop on 'effect of radiation on non-human biota'

    International Nuclear Information System (INIS)

    Takahashi, Sentaro; Takahashi, Tomoyuki

    2011-03-01

    Safety assessment and protection for the radiation exposure were so far mainly based on the radiation effects on human health, because it has been generally recognized that, when human beings are protected, other environmental life, at least in the level of species or groups, will be protected from the radiation hazards, even if individuals may be affected. Recently, with increasing concern on environmental protection, a new framework of radiation protection has been proposed, where non-human biota as well as human beings is included. Researches on the environmental radiation protection need a contribution of multi-disciplinary researchers as similar to the other environmental sciences. Especially, a research field on the biological effect of radiation on non-human biota is fundamental and essential. Therefore, we planned the Workshop entitled Effect of Radiation on the Non-human Biota this time. All the 13 papers presented at the entitled meeting are indexed individually. (J.P.N.)

  14. Paper on operation and maintenance experiences on radiation monitoring instrumentation at NAPS

    International Nuclear Information System (INIS)

    Gupta, J.P.; Vinod Kumar; Sen, S.K.; Malhotra, S.

    2005-01-01

    Narora Atomic Power Station (NAPS) is the first standardized Pressurised Heavy Water Reactor in India commissioned in the year 1989. Many new Radiation Monitoring Systems like Portal Monitors and Ventilation Exhaust Activity Monitors were first time introduced at NAPS. All the Personnel Contamination Monitors and Area Radiation Monitors used at NAPS were designed and developed by Electronics Division, BARC. Only the Portal Monitor was supplied by M/S Herfurth, Germany. The paper highlights the operation and maintenance experiences on Radiation Monitoring Instrumentation at NAPS in the last 15 years of operation. The paper also highlights the different problems faced in Radiation Instruments and our suggestions for improvement in their design for their better availability and long term reliability. (author)

  15. Glance traceability – Web system for equipment traceability and radiation monitoring for the ATLAS experiment

    CERN Document Server

    Ramos de Azevedo Evora, L H; Pommes, K; Galvão, K K; Maidantchik, C

    2010-01-01

    During the operation, maintenance, and dismantling periods of the ATLAS Experiment, the traceability of all detector equipment must be guaranteed for logistic and safety matters. The running of the Large Hadron Collider will expose the ATLAS detector to radiation. Therefore, CERN must follow specific regulations from both the French and Swiss authorities for equipment removal, transport, repair, and disposal. GLANCE Traceability, implemented in C++ and Java/Java3D, has been developed to fulfill the requirements. The system registers and associates each equipment part to either a functional position in the detector or a zone outside the underground area through a 3D graphical user interface. Radiation control of the equipment is performed using a radiation monitor connected to the system: the local background gets stored and the threshold is automatically calculated. The system classifies the equipment as non radioactive if its radiation dose does not exceed that limit value. History for both location traceabi...

  16. Biological effects of low-dose radiation on human population living in high-background radiation areas of Kerala coast

    International Nuclear Information System (INIS)

    Das, Birajalaxmi

    2016-01-01

    High-level natural radiation areas (HLNRA) of Kerala coast is densely populated and known for its wide variation in background radiation dose levels due to uneven distribution of monazite in the beach sand. The background radiation dose varies from 1 to 45 mGv/y. The areas with >1.5mGy/y is considered as HLNRA. Human population inhabiting in this area are exposed to low-dose chronic radiation since generations. Hence, this population provides an ideal situation to study dose response and adaptive response, if any, due to natural chronic low-dose exposure. It has been investigated extensively to study the biological and health effects of long-term low-dose/low-dose radiation exposure. So far over 150, 000 newborns monitored from hospital-based study did not reveal any significant difference in the incidence of any of the malformations and stillbirth between HLNRA and adjacent control areas. A case-control study on cleft lip/palate and mental retardation did not show any association with background radiation dose. Cytogenetic investigation of over 27,000 newborns did not show any significant increase in the frequency of chromosome aberrations and karyotype anomalies. DNA damage endpoints, such as micronuclei, telomere length and DNA strand breaks, did not reveal any significant difference between control and exposed population. Studies on DNA damage and repair revealed efficient repair of DNA strand breaks in HLNRA individuals. Molecular studies using high throughput microarray analysis indicated a large number of genes involved in various molecular and cellular pathways. Indications of in vivo radioadaptive response due to natural chronic low-dose exposure in this population have important implications to human health. (author)

  17. Transcriptional regulation of human IL-5 gene expression by ionizing radiation in jurkat T cells

    Energy Technology Data Exchange (ETDEWEB)

    Lu-Hesselmann, J.; Messer, G.; Kind, P.; Peter, R.U. [Munich Univ., Ludwig-Maximilians (Germany). Dept. of Dermatology; Lu-Hesselmann, J.; Van Beuningen, D.; Peter, R.U. [Federal Armed Forces Medical Academy, Munich (Germany). Institute of Radiobiology

    1997-03-01

    In this study, is performed the functional characterization of the human IL-5 gene promoter in response to ionizing radiation and demonstrated the negative regulatory effects of NF-ATp DNA-binding at position from -117 to -97 bp within the human IL-5 gene promoter. (N.C.)

  18. Realization of radiobiological in vitro cell experiments at conventional X-ray tubes and unconventional radiation sources

    International Nuclear Information System (INIS)

    Beyreuther, Elke

    2010-01-01

    More than hundred years after the discovery of X-rays different kinds of ionizing radiation are ubiquitous in medicine, applied to clinical diagnostics and cancer treatment as well. Irrespective of their nature, the widespread application of radiation implies its precise dosimetric characterization and detailed knowledge of the radiobiological effects induced in cancerous and normal tissue. Starting with in vitro cell irradiation experiments, which define basic parameters for the subsequent tissue and animal studies, the whole multi-stage process is completed by clinical trials that translate the results of fundamental research into clinical application. In this context, the present dissertation focuses on the establishment of radiobiological in vitro cell experiments at unconventional, but clinical relevant radiation qualities. In the first part of the present work the energy dependent biological effectiveness of photons was studied examining low-energy X-rays (≤ 50 keV), as used for mammography, and high-energy photons (≥ 20 MeV) as proposed for future radiotherapy. Cell irradiation experiments have been performed at conventional X-ray tubes providing low-energy photons and 200 kV reference radiation as well. In parallel, unconventional quasi-monochromatic channeling X-rays and high-energy bremsstrahlung available at the radiation source ELBE of the Forschungszentrum Dresden-Rossendorf were considered for radiobiological experimentation. For their precise dosimetric characterization dosimeters based on the thermally stimulated emission of exoelectrons and on radiochromic films were evaluated, whereas just the latter was found to be suitable for the determination of absolute doses and spatial dose distributions at cell position. Standard ionization chambers were deployed for the online control of cell irradiation experiments. Radiobiological effects were analyzed in human mammary epithelial cells on different subcellular levels revealing an increasing amount

  19. Realization of radiobiological in vitro cell experiments at conventional X-ray tubes and unconventional radiation sources

    Energy Technology Data Exchange (ETDEWEB)

    Beyreuther, Elke

    2010-09-10

    More than hundred years after the discovery of X-rays different kinds of ionizing radiation are ubiquitous in medicine, applied to clinical diagnostics and cancer treatment as well. Irrespective of their nature, the widespread application of radiation implies its precise dosimetric characterization and detailed knowledge of the radiobiological effects induced in cancerous and normal tissue. Starting with in vitro cell irradiation experiments, which define basic parameters for the subsequent tissue and animal studies, the whole multi-stage process is completed by clinical trials that translate the results of fundamental research into clinical application. In this context, the present dissertation focuses on the establishment of radiobiological in vitro cell experiments at unconventional, but clinical relevant radiation qualities. In the first part of the present work the energy dependent biological effectiveness of photons was studied examining low-energy X-rays (≤ 50 keV), as used for mammography, and high-energy photons (≥ 20 MeV) as proposed for future radiotherapy. Cell irradiation experiments have been performed at conventional X-ray tubes providing low-energy photons and 200 kV reference radiation as well. In parallel, unconventional quasi-monochromatic channeling X-rays and high-energy bremsstrahlung available at the radiation source ELBE of the Forschungszentrum Dresden-Rossendorf were considered for radiobiological experimentation. For their precise dosimetric characterization dosimeters based on the thermally stimulated emission of exoelectrons and on radiochromic films were evaluated, whereas just the latter was found to be suitable for the determination of absolute doses and spatial dose distributions at cell position. Standard ionization chambers were deployed for the online control of cell irradiation experiments. Radiobiological effects were analyzed in human mammary epithelial cells on different subcellular levels revealing an increasing amount

  20. Determination of tin equilibrium isotope fractionation factors from synchrotron radiation experiments

    NARCIS (Netherlands)

    Polyakov, VB; Mineev, SD; Clayton, RN; Hu, G; Mineev, KS

    2005-01-01

    A method of determination of the reduced isotopic partition function ratio (beta-factor) from the partial density of state (PDOS) obtained by inelastic nuclear resonant X-ray scattering (INRXS) in synchrotron radiation experiments has been established. The method has been demonstrated by the example

  1. Multiple Pyogenic Abscess of the Hybrid Mice on the Course of Radiation Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sung Heon; Shin, Sei One; Kim, Myung Se; Choi, Won Hee; Kim, Seung Hoon [Yeungnam University College of Medicine, Daegu (Korea, Republic of)

    1985-12-15

    Even though the mechanism and the nature of radiation induced pneumonitis, esophagitis and gastroenteritis were detailed by many authors, complicated secondary infection is still serious problem, sometimes fatal, even today. We experience a case of multiple pyogenic abscess in subcutaneous tissue of the back and both kidneys which could not differentiate from multiple metastatic sarcoma grossly, and report with review of literatures, lab. findings.

  2. Conceptual design of a Moving Belt Radiator (MBR) shuttle-attached experiment

    Science.gov (United States)

    Aguilar, Jerry L.

    1990-01-01

    The conceptual design of a shuttle-attached Moving Belt Radiator (MBR) experiment is presented. The MBR is an advanced radiator concept in which a rotating belt is used to radiate thermal energy to space. The experiment is developed with the primary focus being the verification of the dynamic characteristics of a rotating belt with a secondary objective of proving the thermal and sealing aspects in a reduced gravity, vacuum environment. The mechanical design, selection of the belt material and working fluid, a preliminary test plan, and program plan are presented. The strategy used for selecting the basic sizes and materials of the components are discussed. Shuttle and crew member requirements are presented with some options for increasing or decreasing the demands on the STS. An STS carrier and the criteria used in the selection process are presented. The proposed carrier for the Moving Belt Radiator experiment is the Hitchhiker-M. Safety issues are also listed with possible results. This experiment is designed so that a belt can be deployed, run at steady state conditions, run with dynamic perturbations imposed, verify the operation of the interface heat exchanger and seals, and finally be retracted into a stowed position for transport back to earth.

  3. Conservation experiments applying radiation-curable impregnating agents to intact and artifically decayed wood samples

    International Nuclear Information System (INIS)

    Schaudy, R.; Slais, E.

    1983-02-01

    Conservation experiments have been performed applying 10 selected impregnating agents to intact and chemically as well as biologically decayed wood samples. The quality of the radiation-curable impregnating agents could be valued by determination of the monomer uptake, the alteration of dimensions and volume and the deformation of the samples. The results are to be discussed. (Author) [de

  4. Repair of human DNA: radiation and chemical damage in normal and xeroderma pigmentosum cells

    International Nuclear Information System (INIS)

    Regan, J.D.; Setlow, R.B.

    1976-01-01

    We present the experimental evidence we have gathered, using a particular assay for DNA repair in human cells, the photolysis of bromodeoxyuridine (BrdUrd) incorporated during repair. This assay characterizes the sequence of repair events that occur in human cells after radiation, both ultraviolet and ionizing, and permits an estimation of the size of the average repaired region after these physical insults to DNA. We will discuss chemical insults to DNA and attempt to liken the repair processes after chemical damages of various kinds to those repair processes that occur in human DNA after damage from physical agents. We will also show results indicating that, under certain conditions, repair events resembling those seen after uv-irradiation can be observed in normal human cells after ionizing radiation. Furthermore the XP cells, defective in the repair of uv-induced DNA damage, show defective repair of these uv-like DNA lesions induced by ionizing radiation

  5. Brain and Social Networks: Fundamental Building Blocks of Human Experience.

    Science.gov (United States)

    Falk, Emily B; Bassett, Danielle S

    2017-09-01

    How do brains shape social networks, and how do social ties shape the brain? Social networks are complex webs by which ideas spread among people. Brains comprise webs by which information is processed and transmitted among neural units. While brain activity and structure offer biological mechanisms for human behaviors, social networks offer external inducers or modulators of those behaviors. Together, these two axes represent fundamental contributors to human experience. Integrating foundational knowledge from social and developmental psychology and sociology on how individuals function within dyads, groups, and societies with recent advances in network neuroscience can offer new insights into both domains. Here, we use the example of how ideas and behaviors spread to illustrate the potential of multilayer network models. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Effect of estradiol on radiation-induced chromosome aberrations in human lymphocytes

    International Nuclear Information System (INIS)

    Kanda, Reiko; Hayata, Isamu

    1999-01-01

    As a part of studies on physiological factors that affect radiosensitivity, we examined the in vitro effect of estradiol (E2) on the yield of radiation-induced chromosome aberrations in human peripheral lymphocytes. Lymphocytes were cultured for 3 days in the medium containing E2 at 0-100000 ng/ml. On the second day, they were irradiated by X-rays at 3 Gy, and then 2% phytohemagglutinin and 0.05 μg/ml colcemid were added to the medium. After further 48 h, mitotic indices and the yields of chromosome aberrations were examined at various E2 concentrations. E2 treatment at concentrations above 1000 ng/ml resulted in dose-related inhibition of mitosis. Repeated experiments showed that the yield of dicentrics plus centric rings in the culture containing E2 at 100 ng/ml was significantly higher than the yields at 0 ng/ml. Similarly, the yield of total chromosome breaks in the culture containing E2 at 100 ng/ml was significantly higher than that at 1 ng/ml. This study provides the direct evidence in human that radiosensitivity may vary in relation to hormonal conditions. (author)

  7. DNA repair, human cancer and assessment of radiation hazards

    International Nuclear Information System (INIS)

    Paterson, M.C.; Myers, D.K.

    1979-09-01

    Cancers, like genetic defects, are thought to be caused primarily by changes in DNA. Part of the evidence in support of this hypothesis derives from the study of certain rare hereditary disorders in man associated with high risk of cancer. Cells derived from patients suffering from at least one of these disorders, ataxia telangiectasia, appear to be defective in their ability to repair the damage caused by radiation and/or certain other environmental agents. Studies of the consequences of DNA repair suggest that currently accepted estimates of the carcinogenic hazards of low level radiation are substantially correct. There would appear to be some margin of safety involved in these risk estimates for the majority of the population, but any major reduction in the currently accepted risk estimates appears inadvisable in view of the existence of potentially radiosensitive subgroups forming a minority in the general population. (author)

  8. Radiation protection for human missions to the Moon and Mars

    International Nuclear Information System (INIS)

    Simonsen, L.C.; Nealy, J.E.

    1991-02-01

    Radiation protection assessments are performed for advanced Lunar and Mars manned missions. The Langley cosmic ray transport code and the nucleon transport code are used to quantify the transport and attenuation of galactic cosmic rays and solar proton flares through various shielding media. Galactic cosmic radiation at solar maximum and minimum, as well as various flare scenarios are considered. Propagation data for water, aluminum, liquid hydrogen, lithium hydride, lead, and lunar and Martian regolith (soil) are included. Shield thickness and shield mass estimates required to maintain incurred doses below 30 day and annual limits (as set for Space Station Freedom and used as a guide for space exploration) are determined for simple geometry transfer vehicles. On the surface of Mars, dose estimates are presented for crews with their only protection being the carbon dioxide atmosphere and for crews protected by shielding provided by Martian regolith for a candidate habitat

  9. Experimental Determination of the Neutron Radiation-Dose Distribution in the Human Phantom

    Energy Technology Data Exchange (ETDEWEB)

    Stipcic, Neda [Institute Rudjer Bogkovic, Zagreb, Yugoslavia (Serbia)

    1967-01-15

    The quality of the radiation delivering the radiation dose to the human phantom is quite different from that of the incident neutron beam. This paper describes the experimental investigation of the variation of neutron dose related to the variation of neutron fluence with depth in the human phantom. The distribution of neutron radiation was determined in the human phantom - a cube of paraffin wax 25 cm x 25 cm x 50 cm with a density of 0.92 cm{sup -3}. Po-Be and Ra-Be point sources were used as neutron sources. Neutron fluences were measured using different types of detector: scintillation detector, BF{sub 3} counter, and nuclear-track emulsions. Since the fluence measurements with these three types of detectors were carried out under the same experimental conditions, it was possible to separate and analyse each part of the radiation dose in the paraffin. From the investigations, the distribution of the total radiation dose was obtained as a function of the paraffin depth. The maximum value of this dose distribution is constant with respect to the distance between the source and the paraffin phantom. From the results obtained, some conclusions may be drawn concerning the amount of absorbed radiation dose in the human phantom. (author)

  10. Hazards of ionizing radiations for human beings and environment with respect to nuclear facilities

    International Nuclear Information System (INIS)

    Huebner, Felix; Jung, Jennifer Jana; Schultmann, Frank

    2017-01-01

    Worldwide, nuclear fission is used to produce electricity. On the one hand, the low emission of CO_2 is often mentioned as an advantage of this technology. On the other hand, warnings about the dangers of nuclear fission are mentioned. Consequently, an overview about the dangers of ionizing radiation to human beings as well as animals and the environment is important. However, the focus will be on possible health effects for humans with regards to nuclear power plants. In nuclear power plants, both natural types of radiation and artificially produced radiation occur. During normal operation, it is possible that small quantities of this ionizing radiation are released to the environment. In case of nuclear disasters or faults during decommissioning and dismantling processes the consequences of thereby emitted quantities can be even more severe. Reference nuclides vary by reactor type, operating stage and respective incident. At the beginning, different types of radiation and their characteristics and effects on the affected organism are explained. Sensitive organs are emphasized in this context. The individual risk is determined by numerous factors and therefore cannot be predicted. Based on scientific studies and medical publications the hazards of ionizing radiation are compiled. Effects of high exposure of ionizing radiation are well-investigated. Scientists are still divided over the connection between several diseases and the exposure to low doses of ionizing radiation. For this reason, the positions of different international organizations are critically contrasted in this study.

  11. Novel Human Radiation Exposure Biomarker Panel Applicable for Population Triage

    Energy Technology Data Exchange (ETDEWEB)

    Bazan, Jose G. [Department of Radiation Oncology, Stanford University, Stanford, California (United States); Chang, Polly; Balog, Robert; D' Andrea, Annalisa; Shaler, Thomas; Lin, Hua; Lee, Shirley; Harrison, Travis [SRI International, Menlo Park, California (United States); Shura, Lei; Schoen, Lucy; Knox, Susan J. [Department of Radiation Oncology, Stanford University, Stanford, California (United States); Cooper, David E., E-mail: david.cooper@sri.com [SRI International, Menlo Park, California (United States)

    2014-11-01

    Purpose: To identify a panel of radiation-responsive plasma proteins that could be used in a point-of-care biologic dosimeter to detect clinically significant levels of ionizing radiation exposure. Methods and Materials: Patients undergoing preparation for hematopoietic cell transplantation using radiation therapy (RT) with either total lymphoid irradiation or fractionated total body irradiation were eligible. Plasma was examined from patients with potentially confounding conditions and from normal individuals. Each plasma sample was analyzed for a panel of 17 proteins before RT was begun and at several time points after RT exposure. Paired and unpaired t tests between the dose and control groups were performed. Conditional inference trees were constructed based on panels of proteins to compare the non-RT group with the RT group. Results: A total of 151 patients (62 RT, 41 infection, 48 trauma) were enrolled on the study, and the plasma from an additional 24 healthy control individuals was analyzed. In comparison with to control individuals, tenascin-C was upregulated and clusterin was downregulated in patients receiving RT. Salivary amylase was strongly radiation responsive, with upregulation in total body irradiation patients and slight downregulation in total lymphoid irradiation patients compared with control individuals. A panel consisting of these 3 proteins accurately distinguished between irradiated patients and healthy control individuals within 3 days after exposure: 97% accuracy, 0.5% false negative rate, 2% false positive rate. The accuracy was diminished when patients with trauma, infection, or both were included (accuracy, 74%-84%; false positive rate, 14%-33%, false negative rate: 8%-40%). Conclusions: A panel of 3 proteins accurately distinguishes unirradiated healthy donors from those exposed to RT (0.8-9.6 Gy) within 3 days of exposure. These findings have significant implications in terms of triaging individuals in the case of nuclear or other

  12. Effect of ethanol of the radiation sensitivity of human hemoglobin

    International Nuclear Information System (INIS)

    Szweda-Lewandowska, Z.; Puchala, M.

    1981-01-01

    Radiation sensitivity of oxy-, deoxy-, and methemoglobin (HbOs, Hbbj, and MetHb) in water solutions containing 0.2 M ethanol and in ethanol-free solutions was compared. Radiation sensitivity was estimated on the basis of changes in absorbance at the Soret band (a = 430 nm for deoxyhemoglobin), changes in the absorbance ration Avqv/Avwt determined after conversion of irradiated preparations to methemoglobin, and changes in the value of parameters describing the reaction of hemoglobin oxygenation. The protection coefficient p of hemoglobin by ethanol (ratio of a change in the absence of ethanol to that in its presence) calculated from changes in absorbance at the Soret band equaled about 1.5 at a 4-Mrad dose in all bases except MetHb irradiated in air for which p was much higher (about 3.2). The protection coefficient p' calculated from Dtx values for changes in Avchemically bondv/Avwt equaled 2.2 for HbOs, and 2.8 for MetHb for preparations irradiated in air; p' = 1.7 for Hbbj and 1.8 for MetHb for preparations irradiated under argon. On the basis of these results, the role of /sup ./OH radicals and oxygen in the radiation damage of hemoglobin is discussed

  13. Microwave hyperthermia as an adjuvant to radiation therapy. Summary experience of 256 multifraction treatment cases

    International Nuclear Information System (INIS)

    Bicher, H.I.

    1985-01-01

    Analysis is presented of a series of 256 human tumors treated under multifraction protocol regimes with standard controlled hyperthermia parameters and increasing doses of radiation therapy. Air cooled microwave applicators intracavitary and interstitial antennae operating at 915 or 300 MHz were used in various sites. Temperatures were measured by micro-thermocouples. Minimum tumor temperatures of 42 0 C were maintained at 1 hour, twice weekly. Treatment included a radiation dose of 1600-1700 rads. Tumor response was 94% with 60% or more total response. Frequency and duration of total responses depended mainly on the radiation dose. Skin tumors, melanomas, chest wall recurrences responded better than head and neck or intrapelvic recurrences. Side effects observed were minor burns; proctitis or oesophagitis with intracavitary devices; ulcerations or fistulae due to rapid tumor regression; 4 cases of pleuritis treating chest wall. Overall toxicity was less than 5%. In conclusion: 1) Combination heat-low dose radiation offers good palliation. 2) Response depends on radiation dose. 3) Combination of full dose radiation therapy plus hyperthermia proves to be well tolerated

  14. An in vitro study of the effects of low-level laser radiation on human blood

    Science.gov (United States)

    Siposan, Dan G.; Lukacs, Adalbert

    2003-12-01

    In the last time the study of the effects of LLLR on the blood is considered to be a subject of great importance in elucidating the mechanisms of action between LLLR and biologic tissues. Different methods of therapy by blood irradiation have been developed and used in clinical purposes with benefic effects. This study investigates some in vitro effects of LLLR on some selected rheologic indices of human blood. After establishing whether or not damaging effects could appear due to laser irradiation of the blood, we tried to find a new method for rejuvenating the blood preserved in MacoPharma-type bags. Blood samples were obtained from adult regular donors (volunteers). HeNe laser and laser diodes were used as radiation source, in a wide range of wavelengths, power densities, doses and other parameters of irradiation protocol. In the first series of experiments we established that LLLR does not alter the fresh blood from healthy donors, for doses between 0 and 10 J/cm3 and power densities between 30 and 180 mW/cm3. In the second series of experiments we established that LLLR does have, in some specific conditions, a revitalizing effect on the erythrocytes in preserved blood. We concluded that laser irradiation of the preserved blood, following a selected protocol of irradiation, could be used as a new method to improve the performances of preservation: prolonging the period of storage and blood rejuvenation before transfusion.

  15. Effects of radiofrequency radiation emitted by cellular telephones on the cognitive functions of humans.

    Science.gov (United States)

    Eliyahu, Ilan; Luria, Roy; Hareuveny, Ronen; Margaliot, Menachem; Meiran, Nachshon; Shani, Gad

    2006-02-01

    The present study examined the effects of exposure to Electromagnetic Radiation emitted by a standard GSM phone at 890 MHz on human cognitive functions. This study attempted to establish a connection between the exposure of a specific area of the brain and the cognitive functions associated with that area. A total of 36 healthy right-handed male subjects performed four distinct cognitive tasks: spatial item recognition, verbal item recognition, and two spatial compatibility tasks. Tasks were chosen according to the brain side they are assumed to activate. All subjects performed the tasks under three exposure conditions: right side, left side, and sham exposure. The phones were controlled by a base station simulator and operated at their full power. We have recorded the reaction times (RTs) and accuracy of the responses. The experiments consisted of two sections, of 1 h each, with a 5 min break in between. The tasks and the exposure regimes were counterbalanced. The results indicated that the exposure of the left side of the brain slows down the left-hand response time, in the second-later-part of the experiment. This effect was apparent in three of the four tasks, and was highly significant in only one of the tests. The exposure intensity and its duration exceeded the common exposure of cellular phone users.

  16. Radiation beamline testbeds for the simulation of planetary and spacecraft environments for human and robotic mission risk assessment

    Science.gov (United States)

    Wilkins, Richard

    experimental areas associated with the above facilities. CRESSE has broad expertise in space radiation in the areas of space radiation environment modeling, Monte-Carlo radiation transport modeling, space radiation instrumentation and dosimetry, radiation effects on electronics, and multi-functional composite shielding materi-als. The BERT and ERNIE testbeds will be utilized in individual and collaborative research incorporating this expertise. The research goal is to maximize the technical readiness level (TRL) of radiation instrumentation for human and robotic missions, optimizing the return value of CRESSE for NASA exploration and international co-operative missions. Outcomes and knowledge from research utilizing BERT and ERNIE will be applied to a variety of scien-tific and engineering disciplines vital for safe and reliable execution of future space exploration missions, which can be negatively impacted by the space radiation environment. The testbeds will be central to a variety of university educational activities and educational goals of NASA. Specifically, BERT and ERNIE will enhance educational opportunities in science, technol-ogy, engineering and mathematics (STEM) disciplines for engineering and science students at PVAMU, a historically black college/university. Preliminary data on prototype testbed configurations, including simulated lunar regolith (JSC-1A stimulant based on Apollo 11 samples), regolith/polyethylene composites, and dry ice, will be presented to demonstrate the usefulness of BERT and ERNIE in radiation beam line experiments.

  17. Design of two digital radiation tolerant integrated circuits for high energy physics experiments data readout

    CERN Document Server

    Bonacini, Sandro

    2003-01-01

    High Energy Physics research (HEP) involves the design of readout electron- ics for its experiments, which generate a high radiation ¯eld in the detectors. The several integrated circuits placed in the future Large Hadron Collider (LHC) experiments' environment have to resist the radiation and carry out their normal operation. In this thesis I will describe in detail what, during my 10-months partic- ipation in the digital section of the Microelectronics group at CERN, I had the possibility to work on: - The design of a radiation-tolerant data readout digital integrated cir- cuit in a 0.25 ¹m CMOS technology, called \\the Kchip", for the CMS preshower front-end system. This will be described in Chapter 3. - The design of a radiation-tolerant SRAM integrated circuit in a 0.13 ¹m CMOS technology, for technology radiation testing purposes and fu- ture applications in the HEP ¯eld. The SRAM will be described in Chapter 4. All the work has carried out under the supervision and with the help of Dr. Kostas Klouki...

  18. Chromosomal changes in cultured human epithelial cells transformed by low- and high-LET radiation

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Tracy Chui-hsu; Craise, L.M; Prioleau, J.C.; Stampfer, M.R.; Rhim, J.S.

    1990-11-01

    For a better assessment of radiation risk in space, an understanding of the responses of human cells, especially the epithelial cells, to low- and high-LET radiation is essential. In our laboratory, we have successfully developed techniques to study the neoplastic transformation of two human epithelial cell systems by ionizing radiation. These cell systems are human mammary epithelial cells (H184B5) and human epidermal keratinocytes (HEK). Both cell lines are immortal, anchorage dependent for growth, and nontumorigenic in athymic nude nice. Neoplastic transformation was achieved by irradiation cells successively. Our results showed that radiogenic cell transformation is a multistep process and that a single exposure of ionizing radiation can cause only one step of transformation. It requires, therefore, multihits to make human epithelial cells fully tumorigenic. Using a simple karyotyping method, we did chromosome analysis with cells cloned at various stages of transformation. We found no consistent large terminal deletion of chromosomes in radiation-induced transformants. Some changes of total number of chromosomes, however, were observed in the transformed cells. These transformants provide an unique opportunity for further genetic studies at a molecular level. 15 refs., 9 figs., 2 tabs.

  19. Chromosomal changes in cultured human epithelial cells transformed by low- and high-LET radiation

    International Nuclear Information System (INIS)

    Yang, Tracy Chui-hsu; Craise, L.M; Prioleau, J.C.; Stampfer, M.R.; Rhim, J.S.

    1990-11-01

    For a better assessment of radiation risk in space, an understanding of the responses of human cells, especially the epithelial cells, to low- and high-LET radiation is essential. In our laboratory, we have successfully developed techniques to study the neoplastic transformation of two human epithelial cell systems by ionizing radiation. These cell systems are human mammary epithelial cells (H184B5) and human epidermal keratinocytes (HEK). Both cell lines are immortal, anchorage dependent for growth, and nontumorigenic in athymic nude nice. Neoplastic transformation was achieved by irradiation cells successively. Our results showed that radiogenic cell transformation is a multistep process and that a single exposure of ionizing radiation can cause only one step of transformation. It requires, therefore, multihits to make human epithelial cells fully tumorigenic. Using a simple karyotyping method, we did chromosome analysis with cells cloned at various stages of transformation. We found no consistent large terminal deletion of chromosomes in radiation-induced transformants. Some changes of total number of chromosomes, however, were observed in the transformed cells. These transformants provide an unique opportunity for further genetic studies at a molecular level. 15 refs., 9 figs., 2 tabs

  20. Transient Genome-Wide Transcriptional Response to Low-Dose Ionizing Radiation In Vivo in Humans

    International Nuclear Information System (INIS)

    Berglund, Susanne R.; Rocke, David M.; Dai Jian; Schwietert, Chad W.; Santana, Alison; Stern, Robin L.; Lehmann, Joerg; Hartmann Siantar, Christine L.; Goldberg, Zelanna

    2008-01-01

    Purpose: The in vivo effects of low-dose low linear energy transfer ionizing radiation on healthy human skin are largely unknown. Using a patient-based tissue acquisition protocol, we have performed a series of genomic analyses on the temporal dynamics over a 24-hour period to determine the radiation response after a single exposure of 10 cGy. Methods and Materials: RNA from each patient tissue sample was hybridized to an Affymetrix Human Genome U133 Plus 2.0 array. Data analysis was performed on selected gene groups and pathways. Results: Nineteen gene groups and seven gene pathways that had been shown to be radiation responsive were analyzed. Of these, nine gene groups showed significant transient transcriptional changes in the human tissue samples, which returned to baseline by 24 hours postexposure. Conclusions: Low doses of ionizing radiation on full-thickness human skin produce a definable temporal response out to 24 hours postexposure. Genes involved in DNA and tissue remodeling, cell cycle transition, and inflammation show statistically significant changes in expression, despite variability between patients. These data serve as a reference for the temporal dynamics of ionizing radiation response following low-dose exposure in healthy full-thickness human skin

  1. Bringing radiation protection into harmony with human life and the ecosystem

    International Nuclear Information System (INIS)

    Rockwell, T.

    2000-01-01

    A radiation protection policy that is truly in harmony with human life and the ecosystem cannot insist that radiation doses be reduced to as low as achievable regardless of the impact of such a policy on other aspects of human life and the ecosystem. This potential conflict of purposes can be approached from several directions, some of which are explored here. First, we must consider the presence of a large and variable background of natural radiation, whose health and ecological effects are virtually identical to those from human-generated radiation. To attempt to measure, account for, and reduce additional radiation sources that are far smaller than this background-indeed, far smaller than the natural variations in the background, affronts both science and common sense. Second, to base policy on extrapolation of several orders of magnitude from health effects resulting from high-level, high-dose rate, radiation is another serious departure from proper scientific practice. Third, to justify current policy as being conservative in the face of uncertainty is wrong on both counts. The uncertainty claimed by the policy makers is based on their unwillingness to consider and apply the enormous body of available evidence. The presumption of conservatism is based on the issue in question: that any level of radiation is deemed potentially harmful. Fourth, by not fully considering the cost of implementing current radiation policy, limited societal resources are diverted from critical needs, for little or no societal benefit. There are good data showing that health of the people and the environment are directly impacted by the amount of money available in the society to benefit real needs. In addition, the fear generated by the presumption that all radiation is harmful, leads to avoidance of life-saving medical techniques such as mammograms, irradiation of food, applications of radiation such as smoke detectors and medical research, reduction of air and ground pollution

  2. Method of protecting human skin from actinic radiation

    International Nuclear Information System (INIS)

    Fusaro, R.M.

    1975-01-01

    Enhanced protection from sunlight is achieved by applying to human skin beforehand separate, time-spaced applications of (1) a carbonyl compound which is reactive with amino groups in human skin, for example dihydroxyacetone, and (2) a benzo- or naptho-quinone such as lawsone. Preferably several sequential applications of each active component in a separate carrier are made the evening before the first exposure, and protection is thereafter maintained by applying each component separately each evening

  3. 1991 implementation of As Low As Reasonably Achievable (ALARA) administrative radiation exposure levels: Experiences and lessons learned

    International Nuclear Information System (INIS)

    Aldridge, T.L.; Baumann, B.L.

    1993-06-01

    As Low As Reasonably Achievable (ALARA) radiation exposure levels were implemented on January 1, 1991, by Westinghouse Hanford Company (WHC), a prime US Department of Energy (DOE) contractor, located in Richland, Washington. This paper describes the radiation exposure levels which were implemented and the associated experiences and lessons learned. The issue of a report from the Committee on Biological Effectiveness of Ionizing Radiation in 1989 prompted DOE to re-evaluate its position on radiation exposure limits and the resulting doses received by occupational radiation workers. DOE requested that all it's contractors determine the impacts to operations from reduced radiation exposure levels

  4. A gas microstrip wide angle X-ray detector for application in synchrotron radiation experiments

    CERN Document Server

    Bateman, J E; Derbyshire, G E; Duxbury, D M; Lipp, J; Mir, J A; Simmons, J E; Spill, E J; Stephenson, R; Dobson, B R; Farrow, R C; Helsby, W I; Mutikainen, R; Suni, I

    2002-01-01

    The Gas Microstrip Detector has counting rate capabilities several orders of magnitude higher than conventional wire proportional counters while providing the same (or better) energy resolution for X-rays. In addition the geometric flexibility provided by the lithographic process combined with the self-supporting properties of the substrate offers many exciting possibilities for X-ray detectors, particularly for the demanding experiments carried out on Synchrotron Radiation Sources. Using experience obtained in designing detectors for Particle Physics we have developed a detector for Wide Angle X-ray Scattering studies. The detector has a fan geometry which makes possible a gas detector with high detection efficiency, sub-millimetre spatial resolution and good energy resolution over a wide range of X-ray energy. The detector is described together with results of experiments carried out at the Daresbury Laboratory Synchrotron Radiation Source.

  5. Tumor necrosis factor alpha selectively sensitizes human immunodeficiency virus-infected cells to heat and radiation

    International Nuclear Information System (INIS)

    Wong, G.H.; McHugh, T.; Weber, R.; Goeddel, D.V.

    1991-01-01

    We report here that infection of the human T-cell line HUT-78 with human immunodeficiency virus (HIV) increases its sensitivity to heat and radiation toxicity. A possible explanation for this result may be the reduced expression of manganous superoxide dismutase (MnSOD) in HIV-infected cells compared to uninfected cells. Tumor necrosis factor alpha (TNF-alpha) further sensitizes HIV-infected cells but not uninfected cells to heat and radiation. This is consistent with the ability of TNF-alpha to induce the expression of MnSOD in uninfected but not in HIV-infected cells. HIV-infected HUT-78 cell lines engineered to overexpress MnSOD are more resistant to heat and radiation than HIV-infected cells that do not overexpress MnSOD. However, treatment with TNF-alpha still sensitizes these cells to heat and radiation

  6. The breast cancer patient's experience of making radiation therapy treatment decisions

    International Nuclear Information System (INIS)

    Halkett, Georgia; Scutter, Sheila; Arbon, Paul; Borg, Martin

    2005-01-01

    Women who are diagnosed with breast cancer have many decisions to make during the course of their treatment. The aims of this paper are to describe the women's experience of making radiation therapy treatment decisions for early breast cancer and to explore how women feel about receiving radiation therapy. An in-depth understanding of the women's experience was developed using a qualitative research approach underpinned by hermeneutic phenomenology. In-depth interviews were conducted with 18 women who had completed treatment for early breast cancer. The themes that emerged from the data were: being challenged, getting ready, beyond control, regaining a sense of control and getting through it. This study provides health professionals with an initial understanding of the women's perspective of the experience of making radiation therapy treatment decisions for early breast cancer. This study concludes by suggesting that further research needs to be conducted to gain an understanding of how other patients feel about treatment decision making and radiation therapy. Copyright (2005) Australian Institute of Radiography

  7. IAEA experience in communicating radiation risks through the RPOP web site

    International Nuclear Information System (INIS)

    Rehani, M.M.; Holmberg, O.

    2015-01-01

    The authors report here their successful experience of communicating information to health professionals, patients and the public on benefits and risks of ionising radiation in medical applications. The approaches used have been based on giving importance to clinical benefits against risks, as well as safety in use against risk of use. Communicating brief messages against catchy questions with positive and pragmatic approach resulted in making web site on radiation protection of patients (RPOP) as the top web site of the world in this area. Credibility of information has been maintained. The results show immense outreach in 213 countries/territories. (authors)

  8. Experience in organizing and operating of local centers of radiation monitoring in Belarus

    International Nuclear Information System (INIS)

    Nesterenko, V.B.; Devojno, A.N.

    1993-01-01

    The paper analyzes the experience in the arrangement and activity of local centres for the radiation monitoring of foods and of articles of daily use established under the control of the rural and urban area administrations at the contaminated territories. The measurement results obtained by the local centres show the deep contamination of food from the local farms and from the local fields and forests, in particular, milk, ferries and mushrooms. RAPIT information system was established automate the processing and analyse of data from the local centres of the radiation monitoring

  9. An example of radiation-education experiment using a new-type handy cloud chamber

    International Nuclear Information System (INIS)

    Kushita, Kouhei

    2005-01-01

    We have developed a new-type handy cloud chamber to overcome shortcomings in the conventional handy cloud chambers. The new-type handy cloud chamber has such advantages as: no dangerous parts or tools are used; can be assembled quickly; has a wider observation window; much less expensive, etc. We have also prepared a new text for this cloud-chamber kit to explain the basic theory of radiation and radioisotopes, which is divided into two levels for children and for adults. Using this new-type handy cloud chamber, we propose an example of an educational experiment on radiation and radioisotopes which can be carried out within one hour. (author)

  10. The influence of surface type on the absorbed radiation by a human under hot, dry conditions

    Science.gov (United States)

    Hardin, A. W.; Vanos, J. K.

    2018-01-01

    Given the predominant use of heat-retaining materials in urban areas, numerous studies have addressed the urban heat island mitigation potential of various "cool" options, such as vegetation and high-albedo surfaces. The influence of altered radiational properties of such surfaces affects not only the air temperature within a microclimate, but more importantly the interactions of long- and short-wave radiation fluxes with the human body. Minimal studies have assessed how cool surfaces affect thermal comfort via changes in absorbed radiation by a human ( R abs) using real-world, rather than modeled, urban field data. The purpose of the current study is to assess the changes in the absorbed radiation by a human—a critical component of human energy budget models—based on surface type on hot summer days (air temperatures > 38.5∘C). Field tests were conducted using a high-end microclimate station under predominantly clear sky conditions over ten surfaces with higher sky view factors in Lubbock, Texas. Three methods were used to measure and estimate R abs: a cylindrical radiation thermometer (CRT), a net radiometer, and a theoretical estimation model. Results over dry surfaces suggest that the use of high-albedo surfaces to reduce overall urban heat gain may not improve acute human thermal comfort in clear conditions due to increased reflected radiation. Further, the use of low-cost instrumentation, such as the CRT, shows potential in quantifying radiative heat loads within urban areas at temporal scales of 5-10 min or greater, yet further research is needed. Fine-scale radiative information in urban areas can aid in the decision-making process for urban heat mitigation using non-vegetated urban surfaces, with surface type choice is dependent on the need for short-term thermal comfort, or reducing cumulative heat gain to the urban fabric.

  11. Comparison of scattering experiments using synchrotron radiation with Monte Carlo simulations using Geant4

    International Nuclear Information System (INIS)

    Gerlach, M.; Krumrey, M.; Cibik, L.; Mueller, P.; Ulm, G.

    2009-01-01

    Monte Carlo techniques are powerful tools to simulate the interaction of electromagnetic radiation with matter. One of the most widespread simulation program packages is Geant4. Almost all physical interaction processes can be included. However, it is not evident what accuracy can be obtained by a simulation. In this work, results of scattering experiments using monochromatized synchrotron radiation in the X-ray regime are quantitatively compared to the results of simulations using Geant4. Experiments were performed for various scattering foils made of different materials such as copper and gold. For energy-dispersive measurements of the scattered radiation, a cadmium telluride detector was used. The detector was fully characterized and calibrated with calculable undispersed as well as monochromatized synchrotron radiation. The obtained quantum efficiency and the response functions are in very good agreement with the corresponding Geant4 simulations. At the electron storage ring BESSY II the number of incident photons in the scattering experiments was measured with a photodiode that had been calibrated against a cryogenic radiometer, so that a direct comparison of scattering experiments with Monte Carlo simulations using Geant4 was possible. It was shown that Geant4 describes the photoeffect, including fluorescence as well as the Compton and Rayleigh scattering, with high accuracy, resulting in a deviation of typically less than 20%. Even polarization effects are widely covered by Geant4, and for Doppler broadening of Compton-scattered radiation the extension G4LECS can be included, but the fact that both features cannot be combined is a limitation. For most polarization-dependent simulations, good agreement with the experimental results was found, except for some orientations where Rayleigh scattering was overestimated in the simulation.

  12. Comparison of scattering experiments using synchrotron radiation with Monte Carlo simulations using Geant4

    Science.gov (United States)

    Gerlach, M.; Krumrey, M.; Cibik, L.; Müller, P.; Ulm, G.

    2009-09-01

    Monte Carlo techniques are powerful tools to simulate the interaction of electromagnetic radiation with matter. One of the most widespread simulation program packages is Geant4. Almost all physical interaction processes can be included. However, it is not evident what accuracy can be obtained by a simulation. In this work, results of scattering experiments using monochromatized synchrotron radiation in the X-ray regime are quantitatively compared to the results of simulations using Geant4. Experiments were performed for various scattering foils made of different materials such as copper and gold. For energy-dispersive measurements of the scattered radiation, a cadmium telluride detector was used. The detector was fully characterized and calibrated with calculable undispersed as well as monochromatized synchrotron radiation. The obtained quantum efficiency and the response functions are in very good agreement with the corresponding Geant4 simulations. At the electron storage ring BESSY II the number of incident photons in the scattering experiments was measured with a photodiode that had been calibrated against a cryogenic radiometer, so that a direct comparison of scattering experiments with Monte Carlo simulations using Geant4 was possible. It was shown that Geant4 describes the photoeffect, including fluorescence as well as the Compton and Rayleigh scattering, with high accuracy, resulting in a deviation of typically less than 20%. Even polarization effects are widely covered by Geant4, and for Doppler broadening of Compton-scattered radiation the extension G4LECS can be included, but the fact that both features cannot be combined is a limitation. For most polarization-dependent simulations, good agreement with the experimental results was found, except for some orientations where Rayleigh scattering was overestimated in the simulation.

  13. Comparison of scattering experiments using synchrotron radiation with Monte Carlo simulations using Geant4

    Energy Technology Data Exchange (ETDEWEB)

    Gerlach, M. [Physikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587 Berlin (Germany); Krumrey, M. [Physikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587 Berlin (Germany)], E-mail: Michael.Krumrey@ptb.de; Cibik, L.; Mueller, P.; Ulm, G. [Physikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587 Berlin (Germany)

    2009-09-11

    Monte Carlo techniques are powerful tools to simulate the interaction of electromagnetic radiation with matter. One of the most widespread simulation program packages is Geant4. Almost all physical interaction processes can be included. However, it is not evident what accuracy can be obtained by a simulation. In this work, results of scattering experiments using monochromatized synchrotron radiation in the X-ray regime are quantitatively compared to the results of simulations using Geant4. Experiments were performed for various scattering foils made of different materials such as copper and gold. For energy-dispersive measurements of the scattered radiation, a cadmium telluride detector was used. The detector was fully characterized and calibrated with calculable undispersed as well as monochromatized synchrotron radiation. The obtained quantum efficiency and the response functions are in very good agreement with the corresponding Geant4 simulations. At the electron storage ring BESSY II the number of incident photons in the scattering experiments was measured with a photodiode that had been calibrated against a cryogenic radiometer, so that a direct comparison of scattering experiments with Monte Carlo simulations using Geant4 was possible. It was shown that Geant4 describes the photoeffect, including fluorescence as well as the Compton and Rayleigh scattering, with high accuracy, resulting in a deviation of typically less than 20%. Even polarization effects are widely covered by Geant4, and for Doppler broadening of Compton-scattered radiation the extension G4LECS can be included, but the fact that both features cannot be combined is a limitation. For most polarization-dependent simulations, good agreement with the experimental results was found, except for some orientations where Rayleigh scattering was overestimated in the simulation.

  14. Acute Radiation Syndrome (ARS) and its harmful effects on human health

    International Nuclear Information System (INIS)

    Khanam, Yasmin; Singh, Yogender

    2012-01-01

    After radiation exposure a series of many clinical syndromes appear that is called as Acute Radiation Syndrome (ARS). ARS also known as radiation toxicology or radiation sickness. Both low and higher doses radiation exposure on human body cause different types of radiation syndromes. These radiations may be ionizing radiations. X-rays and gamma rays etc. some times neutrons or radionuclides may also be deposited in human body and their effective doses cause major injuries or abnormalities even sometimes death also. ARS consist of a sequence of phased symptoms. These symptoms appear after the radiation exposure for several days to several months or sometimes for a long period or years. ARS depends on the quantity of absorbed radiation dose (rad0). ARS is characterized by an initial prodromal stage of malaise, nausea, vomiting, and diarrhea. Critical effects of ARS are Hematologic, that results infections to low white blood cells (WBC), bleeding due to low platelets and anemia due to low red blood cells (RBC), Gastrointestinal results nausea, vomiting, loss of appetite and abdominal pain (exposure doses of 600-1000 rad) and Neurovascular depending on the exposure dose. Neurovascular syndrome typically occurs at exposure doses greater than 1000 rad. It presents with neurological symptoms such as dizziness, headache, or decreased level of consciousness with an absence of vomiting. The clinical course of radiation sickness following a single intensive exposure to whole body radiation is characterized by three successive phases; a prodromal phase, which develops within minutes or hours after exposure, an ensuring latent period, which is relatively asymptomatic; and the main phase of the illness. Complete Blood Count (CBC) are helpful for the diagnosis for ARS. ARS may cause skin damage or loss of epidermis. Person suffering from nausea, vomiting, diarrhea should be admitted to well equipped hospitals or clinics. High exposured persons should be analysed CBC. Their

  15. Human radiation studies: Remembering the early years. Oral history of Dr. Nadine Foreman, M.D., August 19, 1994

    International Nuclear Information System (INIS)

    1995-07-01

    Dr. Nadine Foreman was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). Dr. Foreman was selected for interview because of the position she held at the University of California, San Francisco. Following a brief biographical sketch, Dr. Foreman describes her work with Dr. Mayo Soley using I-131 in treatment of hyperthyroidism, selection criteria for patients in the radioiodine project, work with Dr. Earl Miller, work at Highland Hospital, radioiodine treatment of diffuse toxic goiter (myxedema), the radiophosphorus and radioiodine programs with Dr. Bert Low-Beer, and treatment of polycythemia vera

  16. Human radiation studies: Remembering the early years. Oral history of Dr. Nadine Foreman, M.D., August 19, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    Dr. Nadine Foreman was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). Dr. Foreman was selected for interview because of the position she held at the University of California, San Francisco. Following a brief biographical sketch, Dr. Foreman describes her work with Dr. Mayo Soley using I-131 in treatment of hyperthyroidism, selection criteria for patients in the radioiodine project, work with Dr. Earl Miller, work at Highland Hospital, radioiodine treatment of diffuse toxic goiter (myxedema), the radiophosphorus and radioiodine programs with Dr. Bert Low-Beer, and treatment of polycythemia vera.

  17. Epidemiological and radio-biological studies in high background radiation areas of Kerala coast: implications in radiation protection science and human health

    International Nuclear Information System (INIS)

    Das, Birajalaxmi

    2018-01-01

    Till date, Linear No Threshold hypothesis (LNT) is well accepted in radiation protection science in spite of its limitations. However, dose response studies using multiple biological end points from high-background radiation areas have challenged the linearity. Radio-biological and epidemiological studies from high level natural radiation areas of Kerala coast showed non-linearity as well as efficient repair of DNA damage in HLNRA indicating that dose limits for public exposure needs to be revisited which may have implications in radiation protection science, human health and low dose radiation biology. However, further studies using high throughput approach is required to identify chronic radiation signatures in human population exposed to elevated level of natural background radiation

  18. [Christian responsibility and experimental medicine. Experiments with and on humans, experiments on animals].

    Science.gov (United States)

    Grosse, Heinrich W

    2002-01-01

    The Jewish-Christian convictions that man was created as the image of God founded the "ethics of unavailability" which contrast with the utilitarian "ethics of interests." As man s nature is imperfect according to biblical understanding, those responsible in the field of experimental medicine should counteract all tendencies in society which promote an utopian definition of health and an eugenic mentality (idea of the "perfection of mankind"). Consequently, scientists must reflect their own image of man and the effects of their actions on this image. The goals of experimental medicine must also be examined under the aspect of fairness: do they only benefit a minority in the rich industrial nations? As in research on humans, the ethical evaluation of animal experiments must consider the question of the underlying image of humanity and the responsibility of mankind connected to it. Because of changes in society's values, the validity of traditional anthropocentrism is increasingly questioned. However, this does not affect the view of the special position of man as the bearer of responsibility. Even though there are different biblical statements on the relationship between man and animal, the Christian maxim to minimise violence towards animals can be derived from them. In the case of animal experiments this means: experiments which cause the animals severe suffering must be avoided by waiving the potential gain of knowledge from them. In general: in an ethical discussion on medical experiments using humans or animals, the public must be informed completely and involved effectively. A moratorium must be possible before plans become facts. Thinking about ethical problems in the area of experimental medicine should not be separated from the far-reaching questions about changes in our lifestyle and consumer behaviour.

  19. The response of human glioblastoma in culture to radiation

    International Nuclear Information System (INIS)

    Masuda, Koji; Aramaki, Ryoji; Takagi, Tosuke

    1980-01-01

    Cells from two human glioblastoma multiforme and one mouse glioma were grown in tissue cultures and their X-ray survival curve parameters were determined under oxygenated and hypoxic conditions. These were compared with the survival parameters for mouse fibroblasts (L5) and established cell lines from human carcinoma coli (HeLa S3) irradiated under identical conditions. There was no significant difference in response among the cell lines used. Repair of potentially lethal damage for human glioblastoma and HeLa S3 was assessed by the increase in survival which occurred as the cells were held in density inhibited stationary phase. The magnitude of repair of potentially lethal damage (slope modifying factors) for the glioblastoma and HeLa were 1.9 and 1.1, respectively. (author)

  20. A Generalized Radiation Model for Human Mobility: Spatial Scale, Searching Direction and Trip Constraint.

    Directory of Open Access Journals (Sweden)

    Chaogui Kang

    Full Text Available We generalized the recently introduced "radiation model", as an analog to the generalization of the classic "gravity model", to consolidate its nature of universality for modeling diverse mobility systems. By imposing the appropriate scaling exponent λ, normalization factor κ and system constraints including searching direction and trip OD constraint, the generalized radiation model accurately captures real human movements in various scenarios and spatial scales, including two different countries and four different cities. Our analytical results also indicated that the generalized radiation model outperformed alternative mobility models in various empirical analyses.